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<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHD4</accession>
    <name>A0A088RHD4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_030580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009372">
        <property type="protein sequence ID" value="AIN95293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701001.1">
        <property type="nucleotide sequence ID" value="XM_010702699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHD4"/>
    <dbReference type="GeneID" id="22571924"/>
    <dbReference type="KEGG" id="lpan:LPMP_030580"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_030010300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_030580"/>
    <dbReference type="eggNOG" id="ENOG502RY1Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271041at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="320" mass="35348" checksum="51E7C3C45546298B" modified="2014-11-26" version="1">MSFRYTNHLVAALKHRLYLEAAHRQLVRQTFTGACNGIEVTCTAYGSVVGLRMLDRAVWEPQYRVAADSESTAPATHPAATSSSPPSPPPSPSPSSQRGIDLVKLSASIQAATWQAVQKARAAKEEAHSRSLRRNPQLLAEAKLRDWYEQDANTLYPRPCDGLKNLQATEWMQAVRFGVSQPARYLRSSAACKDAGAGSGGVRTDQKSYETITVLQDEDCDPANIPIGSAHPLFAPGLLQLELNPNVSKVGGSRVDELFVLSEQRKEMRRDEEAFWERVELIRRSQLATIPKGGVKRGYANMSATVQDTIEEKVQLRFTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHG7</accession>
    <name>A0A088RHG7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Elongation initiation factor 2 alpha subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_030930</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009372">
        <property type="protein sequence ID" value="AIN95328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701036.1">
        <property type="nucleotide sequence ID" value="XM_010702734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHG7"/>
    <dbReference type="GeneID" id="22571959"/>
    <dbReference type="KEGG" id="lpan:LPMP_030930"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_030014000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_030930"/>
    <dbReference type="eggNOG" id="KOG2916">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1685042at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04452">
        <property type="entry name" value="S1_IF2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.190:FF:000008">
        <property type="entry name" value="Elongation initiation factor 2 alpha subunit,putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000015">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1130:FF:000005">
        <property type="entry name" value="Putative elongation initiation factor 2 alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1130">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.190">
        <property type="entry name" value="Translation initiation factor 2, subunit 1, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044126">
        <property type="entry name" value="S1_IF2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024055">
        <property type="entry name" value="TIF2_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024054">
        <property type="entry name" value="TIF2_asu_middle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011488">
        <property type="entry name" value="TIF_2_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07541">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110993">
        <property type="entry name" value="eIF-2-alpha, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116742">
        <property type="entry name" value="eIF2alpha middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="5">
        <location>
            <begin position="131"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="380"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="393"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="404"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN95328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="413" mass="46710" checksum="14343E9A46FC7D88" modified="2014-11-26" version="1">MASYSVTDSPETVDYKTKCCCETTDHVYYDVPKEYFRLNQSLARRKLLLTEPFSVPVDSKTLDHLLVLLEKATILSAQVVEGETKGSNNERPEWMRDLNKRQQKFVCGCLGITSWDGKDIPFYVETMPKINDVVWVKITQVNDTSAVVQLLEYGKREGIIPYTEVTRRRVRSMGKLIKVGRTEPAQVIRIDTDKGYIDLSKKLVTPNEAKACEAHFRQGNEVRSIVCHVAEQCDIPPMDAMEMIAYPLYQREPGKHAWTWLYELNQTEDVERILGPLKLDKVVSDCLMSTLKNAMRLKVLTLFAEVEITCFACDGVEAIREVLILGRNYGEGSEPQIHLSVNIIGPPKYGIRARTDMKEEGIQRMKEAIDAMTAEIKKRGGQLKVVTAPQPHGDADDGKKGFDAEDDDDEDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHK3</accession>
    <name>A0A088RHK3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_050160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="AIN95457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703779.1">
        <property type="nucleotide sequence ID" value="XM_010705477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHK3"/>
    <dbReference type="GeneID" id="22572094"/>
    <dbReference type="KEGG" id="lpan:LPMP_050160"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_050006600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_050160"/>
    <dbReference type="eggNOG" id="ENOG502SHVG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267652at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="137"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="13"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="546" mass="59914" checksum="1CB9DEC1B8D1481F" modified="2014-11-26" version="1">MPIIKSRVHSDELHAARDALAAANRDTDALRQRVLEQREQLEECAQQNATLAAELVQAETRLEEAHRLLTETQLHAQAREERHREQMHRMEQNVHTLEDLVQASRRSEREGSNLAYHRVLCAGNGSAEGAERVQLHTERSRTQEELTHCQALRPQRSTSLQCPPTTLTRDSKEVGKPRRSPPRPSPAASPLIAAQALYWQEQLLNISQRAVGSFDEVQQQLRRCLPPTPPSTTHADADSEAHPDDGPLAASASHIADAHQWGRQLRRLQTHFDEVVQADARLISFLLLVARQQSQQVRTLQERWTEAQNTVREAESVLDEANARMTSSAQESAVLRQECAVLTEMQTTLQAQLANRTREHQASVTALHHLQEAHAQLTDVHTSQEKMWTTRLTQAAEAQQQASNYAQKLEAALLDKERLVSTAAASSEQQHRREALAAAKTQVEAFLRQLNASAQQLQSALVSLSSSTSSSVLAASAVAAGGVKKAPSVSSPEPSPPGVSSSAYSASSATVLYSRATPATAASLSPSLPLFDESILLPENAPAAFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHN8</accession>
    <name>A0A088RHN8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_040840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="AIN95408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703730.1">
        <property type="nucleotide sequence ID" value="XM_010705428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHN8"/>
    <dbReference type="GeneID" id="22572043"/>
    <dbReference type="KEGG" id="lpan:LPMP_040840"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040014200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_040840"/>
    <dbReference type="eggNOG" id="ENOG502RVDT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267133at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051144">
        <property type="entry name" value="Formin_homology_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45733">
        <property type="entry name" value="FORMIN-J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="167"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="602"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="897"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="607"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="652"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="663"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="716"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="728"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="746"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="914"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1009"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1064"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1076"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1089"/>
            <end position="1108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1125" mass="124384" checksum="703B8F02277EC335" modified="2014-11-26" version="1">MGNGVSSPSPADSATSSSARASYPAATRGPRVKKILVNAAPRASASSFPSPASMATASTYRQARAQTPEAKSASLQITAVQRRQQIPGVNGTGRAAGSAARGHARNEEDLLLAFTRNADPISLRVLGLIQQADAVPQNIPSEKLRLLQQCYPLLETVPKCRFDQLAVTVYQKEGDIYYQQEDIENAKSTYSRAITLAEKRVARQETDMYMVLKRYVLAMVGLSRIWYDHERDHKGFTFVDHKHPKVPAVDGGDATEDANSSMSSLESSLMSDGGSVFSLNEAILKSMAPRPPRRQTGPFFQRVKVRAPHVTQNVKLNREDEFVLHSRMTRELVASPCELLLLRCCEVVQIGHNSQSELLIPAQIALAQIYEELALYSRALLLVRRCVGILCSVYDYDHPWVVYLMQRADRLEELLEEQLRSNMATKIQATWRMYQAMQQLENVLGHPVRRHQWIPRKYRATPDLNFLEDFVDDMPSDGLLGDAADDGVYGGLGVNREGREQQTTKGSVTVPEQTAMVLQTAPVRETEWHSAEPHYPADVLVRYAPAENAESGDTFTTVVPNATVVGTTQDTQTDTDVQHTEYGDVLTVRTTTITKTITEDVVSSIDNDSDDESSEDEGQPTAPLRGGAPPPPPRQQKQSRGTTYPAHPPPQAAASYSSASSMDKYEEERECLWAERAPKEPQQQRQEQTQVKPHGHAVSTQARRPPPQTSLQAETTEQRRKEKEQPRTSRQAVATSSLLQRRESATQRNPGNGANRSTVHQPEQQPPKAARPRLHPYSSREDENAFGDELSRPAQRGALPQQQPAPPMRDHYSALVAPSSNGSNDEEYDVAPLEGYRDGTAPHQVGESNEVIGGTDVRSSSSEVSPLYVRAVNYKSRRESFQDLVVPNAAYRRESNGCPVFLPPLGYRRRSERSSQSSSMPPPGSESNELVLHPLVHNGSRSPQVQKAPMQPNDPRYRGDHSGMPVYPTAPTNTYPSVHPYVAQAPQTTKTTRDYKIIKRRRVRTYVRESVVSSSTNGENTSSSSSSVNINERMSSASWEEDSASSSSSSSTHVVYVEEAEQTDAASDNSKPNSTSAPRQQQQQPSKQKPARRLSVPHRPHKPRRPTPPKKLLSKTGNGSGAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHQ5</accession>
    <name>A0A088RHQ5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_041050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="AIN95428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703750.1">
        <property type="nucleotide sequence ID" value="XM_010705448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHQ5"/>
    <dbReference type="GeneID" id="22572064"/>
    <dbReference type="KEGG" id="lpan:LPMP_041050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040017700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_041050"/>
    <dbReference type="eggNOG" id="ENOG502SB2I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="248951at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN95428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="108" mass="12733" checksum="E573105329464E98" modified="2014-11-26" version="1">MSRPKQRAAEVTLHHFFKTERVVRMECERREAKARLRLIDTMSGDLDDQLLCVAQFKKEWLQSRRVLEEARQAILQEESSNRADVEDEYKRTTKRVIRHCHPLGTPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RII5</accession>
    <name>A0A088RII5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_070010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009376">
        <property type="protein sequence ID" value="AIN95688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704010.1">
        <property type="nucleotide sequence ID" value="XM_010705708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RII5"/>
    <dbReference type="GeneID" id="22572336"/>
    <dbReference type="KEGG" id="lpan:LPMP_070010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_070010"/>
    <dbReference type="OrthoDB" id="274440at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="398" mass="44332" checksum="7D56A37198F77A6D" modified="2014-11-26" version="1">MRPATRKRLHSVKRSSRHILESLRHKRTFSLSSHSLTSQMSDKQERLTEAELDRALKVYLAHKATHSMAEIAKKQYMEGKTNTSEFLEMTAAMAESLWEKAGEKGVPSIDIKKEMMEAHNIFADKELQEVMDMEDKRKEVRAKIKATKDPLEGYKTKVESAILAHQMSPMAAATATILLGLSGPESQEMSVEERVAEWLSIFVDETCSSRLLAYNVQVAESVAGGMRQWRKVLKRLDAPLVPETERLAHLNRITLEAALNEKQRSTTQRIEGGGTHTTRPRDIFRTPSRDGSDLLEGGAPYAPIIGADGSQVAALDMSSFGALTEESQLRMQDTITHLMREQKTAPRVANHTQGPRNSQNSGRGVGYRGNYRGNGGGNRHGNYRGGEAQEDFPSDSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIK0</accession>
    <name>A0A088RIK0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber evidence="7">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_070220</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="7"/>
    <dbReference type="EMBL" id="CP009376">
        <property type="protein sequence ID" value="AIN95708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704030.1">
        <property type="nucleotide sequence ID" value="XM_010705728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIK0"/>
    <dbReference type="GeneID" id="22572357"/>
    <dbReference type="KEGG" id="lpan:LPMP_070220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_070007100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_070220"/>
    <dbReference type="eggNOG" id="KOG2867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="16120at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04087">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1150:FF:000007">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016325">
        <property type="entry name" value="Phstyr_phstse_ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0697">Rotamase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN95708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="393" mass="44732" checksum="9C3678157E13C40E" modified="2014-11-26" version="1">MRGSDAMAGPAARWRPAQNSEAVRKYTSKAVAPHPPAKVILEDHFLIEVFRRSAAFQKVISYVQGCSEAVESTPNYQRMSTTVNDCDNTVKYLVEDYLPRLHDIATAIPLEDMAQQRFGNRAKRIFHERLEETVVADMEKLVRTFPTSTSRSEEEITAMATELAAYVMDSFGNATRLDFGSGHELHFFIVIMICLEEHGDCGGSLKDDPTVLVPLEVPPPPPVPLEARVEVRKRRQDYIFYIFYDYMRLVRCLQKRYSLEPAGSHGVWGLDDYHHIPYIFGGAQLINADMQPVKPAVDQEATIIHPKDVCDRTKVAMLKDNYLYFGMIAWILENKTGPFHEHSNMLYNISGVEHWAKVYSGMVKMFAAEVLGKFNVSQHLLFGQHLQWNTKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJ94</accession>
    <name>A0A088RJ94_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phosphoglycan beta 1,3 galactosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_020140</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009371">
        <property type="protein sequence ID" value="AIN95194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698159.1">
        <property type="nucleotide sequence ID" value="XM_010699857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJ94"/>
    <dbReference type="GeneID" id="22571824"/>
    <dbReference type="KEGG" id="lpan:LPMP_020140"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_020006600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_020006900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_020140"/>
    <dbReference type="eggNOG" id="ENOG502SHX0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="252344at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF351">
        <property type="entry name" value="BETA-1,3-GALACTOSYLTRANSFERASE PVG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN95194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="915" mass="100130" checksum="147D532BF7777AD2" modified="2014-11-26" version="1">MNVYSATAVRKVPPHLSTEPVMVTSSLRERVWPTLLRVGNAALAPLLSRVSDAMEGASPSSAGQTVPSIIELTDSELTTDASLSKRCVRRDRHFSRCAVGSSVADAPARQPMIRGAMPWHRLATLLRIVFASFLVLTLSLTYLYFSPSHEVQWKGPTTPALAVVSSVVGDASNTYSVSAPWAVLVQHEDAMTRLSLTERSGCDNLELDCETHRVSPSLLPSWTLHLVEPSCVDCTDTATYATAIAATRDLVPQRHGVFATPAAPLGRVGPILFAMLSVTDEISAPDEMPRWLWLNHTYRCVPAVSGELQQVSGANHHTGCPARHPPYLAVMGIPSTDNVMRLQLREAQRRTWLTYLEVARNENGFQGALLQLYLFAASERATTPNVSTAARDTATAAAQAYANASSVAPTVKEYELASKAQESIAGGGAGVTYRQRRMALRSGWTSSKQSDESPCSHIQSVISDGTAERSALSYLSGALSLPVTPAFVAGSRFICHASSALWQEALTHRNVLWIDMMTDRRPTTKKKLGEAKNWGLPVEVGMSQKLILWLAYAYHAFKDVPFIIKGDDDAYVKVPQFLSDVRFITDGEGIRQLPPSPMTTSPLSAAPVLPTPEGSATSALGAASLSSVLPPSSSSIAANSTHAELAGRIATYLLLGAGTRAEAKGSQSGLLHTSASKPPRCVYWGSTRHVSQTRFNAGMLFMAHRQVVQAVLELPESPSIAHLDGIKHREFDVIRMTLRDFDARFAKEYYAAHFTTEDILFGFLIRHRQPRVQQLCPDKKLYYVKESLHRFHDLRVGRAQPVSWSTVVAHRTRPADLHYLHYFFRTEHTADAMHAINASAAMLQRAATWAQAQKSLHPSNVTDWNDLPDTKWATPPSSKPPLVVAPGDGVGVYSYEYMTYRAPKAEVYQGFQSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJG4</accession>
    <name>A0A088RJG4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_090340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN95950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704272.1">
        <property type="nucleotide sequence ID" value="XM_010705970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJG4"/>
    <dbReference type="GeneID" id="22572604"/>
    <dbReference type="KEGG" id="lpan:LPMP_090340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090008400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_090340"/>
    <dbReference type="eggNOG" id="ENOG502SKFF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273727at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="248" mass="26160" checksum="3E6C5F8CC73208DA" modified="2014-11-26" version="1">MVRVGAKRERPCMLVLHVALRAAALPRMEGPQRMEKGAGASASPRELFIWKTSATAEVYATAVMRSMRAYWQLIGGVRYAGPDALTLVSAVWQGIGSSTPGPEAAARGAGSAEGASSPSPPPTSATKTGAIRSRQLPQRRQRISATQRRTGVLRCAVHLSRSVYGDAGAVHVLRAACACVTQTKVAVPLSQLAVDDGAATVVDASKAGAQKRRSGRAEVDVGDVMEQVCHAAVHVARVEHVLPARQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJQ1</accession>
    <name>A0A088RJQ1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyl hydrolase-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_101230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696845.1">
        <property type="nucleotide sequence ID" value="XM_010698543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJQ1"/>
    <dbReference type="GeneID" id="22572860"/>
    <dbReference type="KEGG" id="lpan:LPMP_101230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100019500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_101230"/>
    <dbReference type="eggNOG" id="ENOG502SHC7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="255801at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015045">
        <property type="entry name" value="MPT-1-like_LmxM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37036">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37036:SF2">
        <property type="entry name" value="DUF1861 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08950">
        <property type="entry name" value="DUF1861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN96192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="316" mass="35704" checksum="8A52CCCE6D804CA6" modified="2014-11-26" version="1">MSTPHVVREAKKEFEASKRVYESVLLTFKGVEGYDVYNCSVPFRYNGKLHIYGRVEKREIWAASHVRLFEETGKDEFTVVPNGMTWYLEDPFVSKVKGEALFGGTRIRKVSDRLLTYYCDFYRGGIEQGLYFTTGPDYMKDIRCVELADGRIGVFSRPKTDVYTCIGFTIIDDLSELTQKAISEAEPLNVLHSGAWGGVNQAYLLTSGKVGCIAHYSYNSKDDKDHPTSVYLNYSFVLDPETKEAEMECIIGTRCCYPEYPVKAEKLIDCAFSSGIVMRDDGKCDLYSGLGDTCEGRITIDYPFDGYGTIVDQLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RK87</accession>
    <name>A0A088RK87_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_130060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697090.1">
        <property type="nucleotide sequence ID" value="XM_010698788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RK87"/>
    <dbReference type="GeneID" id="22573116"/>
    <dbReference type="KEGG" id="lpan:LPMP_130060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130005700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_130060"/>
    <dbReference type="eggNOG" id="ENOG502SBRU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272969at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37028:SF9">
        <property type="entry name" value="NUCLEAR PROTEIN MDM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37028">
        <property type="entry name" value="UNNAMED PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="460" mass="50954" checksum="9A803CB30B160DF1" modified="2014-11-26" version="1">MSHSCAQGGPSASSTLSATTTTPTADIVCELSPVQPGRSHDTTTRVEERLLRYGAVYQERLREAQRHKRISEEAALKAIVRLPSPALQRRLFVPTLSLHASAEAARQHRAERQSVLLSEKATPHTCQPAILPVSREMAAAERKRNGWMRLPVGDVLMERHKRVEGHLEEKRQEEVARFSFKPSISARARIIKSSRPVVERLYSGARGTGAGTTAFADVTNLPSTSSAKPKTASAATYQRLYKDAVTRRAHDQEQENLAHVRSKNEFCPRTDTVSGLIAAQRGDTTHERLLRPKAALDRARHVCPEETFAPHINTSSRFERASLSARTAMWQRRRNERLHHALVERAEAEMRGCTFHPNTLHGPSALPQSRAREPTDGCTSSPASIIGSAEELLSRVDLEPFAPLPECDRCAPLFSDDDALPETALADILAVLEEAEYISEALRLHPKTRLDVDQSLPTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKI0</accession>
    <name>A0A088RKI0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PITH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_120020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PITHD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009381">
        <property type="protein sequence ID" value="AIN96330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696983.1">
        <property type="nucleotide sequence ID" value="XM_010698681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKI0"/>
    <dbReference type="GeneID" id="22573008"/>
    <dbReference type="KEGG" id="lpan:LPMP_120020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_120005100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_120020"/>
    <dbReference type="eggNOG" id="KOG1730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2635at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045099">
        <property type="entry name" value="PITH1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175">
        <property type="entry name" value="AD039 HT014 THIOREDOXIN FAMILY TRP26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175:SF1">
        <property type="entry name" value="PITH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PITH" evidence="3">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN96330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="156" mass="17138" checksum="542F50D6BE232C92" modified="2014-11-26" version="1">MSSNQDPICSDDDQELLISAPLSSLCRIKGISVVAPANDTAPSRVKIFVNLVSVSGFCSVRRLVPQEQLQLADGGCEDRIIYRVNATKFSAVSSLTFFFDESYNGEETNVLRIELFGENTGKSTQQQVATNIVYEARGNPADHQSGEDKKSLFEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKP8</accession>
    <name>A0A088RKP8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Leucine-rich repeat-containing protein 51</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_070330</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009376">
        <property type="protein sequence ID" value="AIN95719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704041.1">
        <property type="nucleotide sequence ID" value="XM_010705739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKP8"/>
    <dbReference type="GeneID" id="22572368"/>
    <dbReference type="KEGG" id="lpan:LPMP_070330"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_070008300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_070330"/>
    <dbReference type="eggNOG" id="ENOG502QPQF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46545">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46545:SF1">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="136"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="186"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="245"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="446"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="619"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="212"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="245"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="625"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN95719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="845" mass="91056" checksum="86EA2E863255E6A1" modified="2014-11-26" version="1">MEYEQVEYCRRVVTGAILSQDINDYYNLLSPQVLLVTHFPYPSTSASSNMQAVQRWVRMSEPQHIAAVDAAATFAVSAATAADRGYANTNAKSKGKPAAVAPVGTTGAGGVRSQKRRVRELLRRQEQWRITQQQRYDTFRKRRDRHHRCAADGEDNGVGSADGSDGGGRVGAAVAAAASGRVTVDGCGAPAAPQPQQPQTSADKHLRVGSVGKSNSARCNAPNSGGSATAALTVRFVDGVRWFQQQQRQQQQRQQQQQAQAQTQPPQQRTGSGLLLSSNASTAAAPAGAAAAQTRPAPHSNPIPYEDAAVITEGKLLVSYRFFQLLHWVSFSDGKTAPPTHIAPIEVDIQLRKDILQEDEVLTPPPPPATAQEAYSQLGRQHTERNQALSCIRVVWGADYLLFADTIFLDDGLIVTIHRRMLTVPEVLARAAPGIPLSLQVSCNLAPGPGTQPQTQSSEKGGATSLPAGQGGPTYERGPDLSVARPEQVYHAVEAFYGLTATRIDACSNAWEHLDFSFVEAAEPSMLLRLTPVSGRVHISLPPRATSDPRLVQSIFLNQENDPTKPKQSPSNRTLIKARNKHGEEEAYEFRTQKNCLSFYEDGTSGGAGGSDANAFGVGGGAGAQQRSKNKNSSGDGAAGVTRYDASCVRVSGCHLQAKMDQLVPVLRHLVANCLLTLHSLDLSQNDISSLPDLRVLPLQSLKLHGNAIADWRVVEMQVAPLPYLSILTLHGNPIAEDTKIRAVAGRSGKAAVRDAHCKDPVDRAIREDRGDGDSGYWKRLLALLLRNPDRVAPLRQVDFVTLTSQDYHVAGAYEMFTTGQAGVLAKARSMMSNRTQMQPAGATM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKV9</accession>
    <name>A0A088RKV9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_131410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697221.1">
        <property type="nucleotide sequence ID" value="XM_010698919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKV9"/>
    <dbReference type="GeneID" id="22573251"/>
    <dbReference type="KEGG" id="lpan:LPMP_131410"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130018800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_131410"/>
    <dbReference type="eggNOG" id="ENOG502SMA7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="260227at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="509" mass="54694" checksum="509E65139FF130E0" modified="2014-11-26" version="1">MGWGGLRTSRFHFADATSAEVMSGTCAASDKATLLEQAHQWYRFVAELILGETAAADVGGYRNTHGTRWMGRRGTAAETVGEEEQRLRPRQEHSPAEHLIGQLSQLCPLLRPTAREDDLCGDACALTIRDSALRSFPLNNARAGVHETPPSWQSHTVSSLQNWWDSAADALDALFDAVDMYLDSTSVPPTVGPPALSLPALALGGQSLSQIEAALTGESCIMAGLLLHRDVRPRSGPCYATVVSPVLVVLDLDGTLLRSPLNSISIRAVQVATTAEVRALFVDADFLGSFCESVTRQGHELAICSLTEGTADQWSTSLSVAEAVLCLLSRILPPTRSYLTSTDDVVCLPRSVAGPGKLYHLQELQQRRNARDEGQRLLRSQAHPQLQRQQPTDDAGVEVANDASNSMRLGVFSPPMQTSSSHHDGVVGGLRNPSTLLLPRWLSTDVVLIDDDRENCHIAVTQGYHAASCAETGMSASWYAANPELQVLLGIPASEAAPRSGAHSGRTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RL04</accession>
    <name>A0A088RL04_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_080550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="AIN95864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704186.1">
        <property type="nucleotide sequence ID" value="XM_010705884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RL04"/>
    <dbReference type="GeneID" id="22572517"/>
    <dbReference type="KEGG" id="lpan:LPMP_080550"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000015800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_080550"/>
    <dbReference type="eggNOG" id="ENOG502QWRM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271022at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="352" mass="39625" checksum="73C9A95E7BBBB7A2" modified="2014-11-26" version="1">MMRIGAVRFAPLQACRPLLFFSWLSRSSEHRGSADATWRTNAKDTFISEGAMGLGGGDVGQPMANGASEALDGTGRSTASYRQAGMNGIGGRGVGHGQSFQVGGGAAPGSTVPKQAIDDILMERPAHLTGPNRRPVSYDLEIHRVARAREVAQKEASQQHLRHFDEQNMPRNPLDPNRERASWEFTPTPEHKSLVLLLYRNVLKGLMNYKSVRRRSMIAYARMCFRRRAMATEKLLIDECIEECRRSIYVLEKHHNFTKTGTYEFDSMTIPKDTGQDVKTYMEEVYDPEQSRLQFQNFTDVQPGKEHLHRQGLGPTSGEHHWKDQTSSEAFKVEIRDEDKALRPPPPPEMAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RL55</accession>
    <name>A0A088RL55_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_131280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697208.1">
        <property type="nucleotide sequence ID" value="XM_010698906.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22573238"/>
    <dbReference type="KEGG" id="lpan:LPMP_131280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130017500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_131280"/>
    <dbReference type="eggNOG" id="ENOG502SMC6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267145at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="715"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="900"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="971"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1189"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="392"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="664"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="784"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="900"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1060"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1072"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1224"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1235"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1291"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1307"/>
            <end position="1321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1321" mass="139031" checksum="110CF72F88124EBC" modified="2014-11-26" version="1">MQRQSSTKSDCRNASEALLVQDHAYEMRNGGPPPPPLSSPSLRRAAPAAVANGEMGSRAQPRLPQKPSMHSSSPLSSPTIVVKRTVNDGRSPALSALANHGGANGGGEEQGKEEDQSSCNSVPALWTSHGGATGAVAFTATTCAALIIAATPSLSSSAPSPAPPLSQSHISSISSPHNVRSASQGSGSCQVTSMFKNLLVYPPQVLSAASQHPPSTTMLTAAPEALVAPVPPARLTVTVESPDHTVTPRLSSTAVPIVVAAASFISPECATLSNQLTCSTVGESRRRNSSSAPTSAFQVDDDKAENSVMEGGAGGAGERWPVDPHHRTAPARNTHVSARLEQQNAGTNANATVADSVDGETTWSLRNVDHASEGNGTIYHAHLAASTRSSLAQPSSYSRPARSPACSPSSAAGAASAAPTPISNSVPAAPQSIRNSRNASNLNLAINHVRKSLFIGPPPSPVLSPVATSVASGGAGGPTSLANRGGTALSWHDLQSSSPSLRFGTHDPYNRAAIVATPLRSGVPRTTSFTSHHPPSATAMAPTGSVITRMQMWSASVRANGCAGSASAEDSGATLPYCAVANSDTMSMKSSTADVARRAHDGIMIWAAGGNPSKVPSPPIGEHPLYDPQCDYPFQPHETKRQQVQHASSYEPLYEQQQPEHHQGPGQQLPPHQQNGPQWGEQYQQQTHPQVVQEAPGHYQAFKVLPQHYEQAYPSECQHPRSEQQQRQQQQHQREACDYALQHSNPPQRQEQRYPCPQAPEPHDPYAYQTYPELPQHPLHSVEQQQQYPAQQASNSYASELHQRPQQQHRTQRPYGGRGCNAGSVHHNWNEPRKRTAQDVLPGFFSVDTIQLGDQTHLASDRNGVLHQHNEQQQQQQQRLGNEAPHVAALLASGSSLNNAPWQYPTHHQSCGPAAAPELDSRRSSPAPRTLPYPSVVRQQLQPQLDRSFSAHCDATPARGVQGDYYYSSRAGAESTAATSVTPPYGSDDDEGMRMHGGAVYGLQSWNAERHGGSASAMTVGGMMVAQPPHMAAPVSSRTPNPRACDTRSHRGGSSGGGSTSLNSGTGSGCSVPSNKSILSNNNLGSGMASLKTNENGSSGNANGGGSTGGMVHVCNEDNSADVCSDSGAPAPTLSGAGPNAPISRCYGGGDIRVNAATATAMYGGHTHYPSKNNCAVGTIDVYASQPERRTTDSAAATSPSPEGANGSGSTSSVPFTTPLPRSAGAMNGGAAANHQSSHGSVGSLQVPLNMRPHQQRHPNMGSRAATRWLPRNGSEDYSPHIASPNRRRFSTPSVNQPNQYGNTHCSQKQQKSQALSQEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLG9</accession>
    <name>A0A088RLG9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pseudouridine synthase RsuA/RluA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_150400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697416.1">
        <property type="nucleotide sequence ID" value="XM_010699114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLG9"/>
    <dbReference type="GeneID" id="22573456"/>
    <dbReference type="KEGG" id="lpan:LPMP_150400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150009100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_150400"/>
    <dbReference type="eggNOG" id="KOG1919">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="424794at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF77">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="2">
        <location>
            <begin position="918"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="589"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="698"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="840"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1095" mass="117789" checksum="F41BF1645DBED8AC" modified="2014-11-26" version="1">MRRVRRAQSLSRNASASHADTQRHRCTHGRRAPSLPPSTPQRHPLQLHHGTLPLPFNCVSPPNLLPHCSHLPRYLHTWQPLMVAPSTTAVEPGDRYLTREPCCRQCCHGSSGALLAPPSRSLKHSAVTGGDTEITFPSAAAVDSDAPWIAVRPYSYLFRAPVKGRWLGHGLLELFLKEFAFVPFDAAAAEKVPLLSERGIIPASTTTGTIRSAVVPLLLQQQAASSSLHVSGSATLDRRFTLPAYIEELCEGVLWLRDREVECRAAGRRYQRALIDVVARAQGIHSSTGCTDGGIAKRDHSGMIEAQPHPLPKQMMAPVQATPSTALLCTIPSSEVSTASSDWPAWCRTVLWLTELPSEAEVDALLPHMLSAASTSLSRDSAVAQGSAGAHSASAATVSGTPLPLLLLQQRDLVCHRVWRCEGRMFAHPPLEILRCDVAAALSAVPPEVHARTPVPAAKTLAMLVVSKPPGLPVHPAGRYRKNSVTSILEDVLGGGGDGDARRFYRIEEHHTSATTGSALPHPPYASVVHKTGGFELIRVWLRRPPSSADASAPVLCGPSSLSTLVDEIGVSAEDWAVLKALFMRERDATTQEGRARNPKEDRHASPHGDITIAAETAQPLKRSREAEDGDDSPLSVGNSHCASTEKMTRARSGDAAVAVPSSYTMKAHVVHRLDAATSGVLLFGLNSCTARRTAAAISSKEELDSSDDENSADGDNVANRDDVREVGAGLETLPLSLPAPTSRKVYCARVHGRVDLESIARQQHHCVLRSTSLLTQSTSDEHGAPDVAVAGVGTSGATHHTVAELLVCRPIGCLDHHSSLYWSPDVAITDAWQQRQADAKRLQQQQAPELRNGSLSGGRSKAVRTQEDVAAKNERMRLLTRGGRRDSVGAVTLSLPPVRNGPATLLAHKASAVLSDTSRRVQQYLETLRSAKTALQVMRYDAATDQTVVKCTLGTGRTHQLRVHLASLGHPIVRDRKYIALEAHMRALAKSGEEGTPRGSKAAAVAPRTPLASEALLTRFYESTASTDRAEVNGSDAAAAAVEGRWQPEAVAESRSWSGCICPEAIDLHAWHYTLAYEDGELLSVEVPLPMWAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLM5</accession>
    <name>A0A088RLM5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Protein kinase, putative</fullName>
            <ecNumber evidence="13">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_151110</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="13"/>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697486.1">
        <property type="nucleotide sequence ID" value="XM_010699184.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22573531"/>
    <dbReference type="KEGG" id="lpan:LPMP_151110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150016400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_151110"/>
    <dbReference type="eggNOG" id="KOG0198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1113">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="417078at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030553">
        <property type="term" value="F:cGMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06606">
        <property type="entry name" value="STKc_MAPKKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000805">
        <property type="entry name" value="Mitogen activated kinase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000148">
        <property type="entry name" value="Protein kinase A regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047173">
        <property type="entry name" value="STRAD_A/B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48014">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE FRAY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48014:SF21">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE FRAY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0140">cGMP</keyword>
    <keyword evidence="5" id="KW-0142">cGMP-binding</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="404"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="524"/>
            <end position="636"/>
        </location>
    </feature>
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        <location>
            <begin position="752"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="11">
        <location>
            <begin position="1209"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
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            <begin position="1351"/>
            <end position="1619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="277"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1040"/>
            <end position="1062"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="1655"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="1720"/>
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    <feature type="region of interest" description="Disordered" evidence="8">
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="9"/>
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        </location>
    </feature>
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            <begin position="124"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
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            <begin position="300"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
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            <begin position="1041"/>
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            <begin position="1658"/>
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    <sequence length="2754" mass="294191" checksum="81AC267B7C6EB106" modified="2014-11-26" version="1">MDPAGRSFSGEQQQQASEATGDAGRDTANAPLLQCAETSPFESESTKCSGLVSPPPLAPLSVVVRVVPTLAAATTSTASATFTAPVIVRSSHDLSSSSATPPVTETALISASASSNLRGGNDTDGGDVNEGEEGPFLTNGSIALAEFTSLLNPTENNAILKEHIIHMLRDVDTEETLMRIAHALETQETSETPVDVSTTICTESSHDVESYTHASQSTVTSMSMTQGRRSSVLSRREATSLEGFAGLSFLRSRRRTTSPSAQDCPSLAQPLENRGLYNQSARGLGGPMDVSFSSHTSAGTREEELQMSKQHDNPPSAFMATSASQFSETTATLLDDPLLRELPELPTCIQSEGRRAAVSAAPYTSPFDIISGDAPATAPPPLRVVPKTAAEEQQLRRLLHRCHSFSSLEADTLEAVLKAMDKEIHAAGAAILEQGQPTTEKLYLVSEGTCEAIKNGKSLGPLQPGGTFGELELMYKQAMCAATIRCVTRCVLYTLDEASYHRAVMSSSLQKRRRFEKLTMSVPFLRGLPDFERMKIAEALETRVYKHGKTIIRFGSPGNYMHFIVEGEVKVIGRNSGRRVEVVRLRAGDVVGELEFLFNHLTVADVVATSREVRTACISREHFELIIGPIQDRLKEFVATSSTYEKYYVSEVANESVRSELNRIESSRKHRRVASHDEWTAIGVTNPHGEVLLSAPLALLHGKCGASNSDSTAKGGADAHGQRRQAAGDSDQLSMGLLRFPFAPVAGKDVAVLALREDGLIIYWNSVLERLMSYSADEVVGQNIYSFLLSEREQQSMYTAINAARNYAGEAEAFLKQPNTKSMQFTLARSDGLTKTTIQLTIAPPVVSAGGNAAEVVLGFGKEVREGPQKMLEQPQWLSGQIRTILADGTQTFEERLECIAETLNNFESTYRAMTVSTERLRVVNIRQMMGHVLMNFGGECVSRGISVRQLFEGLPSERAYLDADLLPKCLCYAMKLCLKYSDPGGSIVSIMTTVTEKNGLEFLVINFNLTGDGMPKAIAKFFDSSLNKHSDSCATLSLEVGEDGDSDDDGENYAEESTELRKTMRPGLRRKLLRVQRAVEDQGGTLRMLRNPQDSNIAFLIPFMPASEQDAENAFVEESLSTLADSTSASQSMSLAGMGNGIGPPTAAATATGAGGGHSATFLPGGYSKAAGSVSLAATPAGEASGLSNQSVPGAAVTVPGQPNFSYTTCLAEDTPAHRIMLSSFLWERHHAVLTAFTFEDVVGLAGVADILIIDLQQSAITSPHDLDPITRLREMLRHMAVIITATNFDLVSSDTYAAAGFITLKKPCTPVQAMKAIRHAEEKSAVVKLERMRIEQTRETLARNSRGAWRHGALLGKGSSGEVYEAYDVLTGGKMAVKEMRLGNNDAKIEQFVQEISTMCNLQHPNIIHYFYCEESKEQKVIRVFMEFAGGGTLQSLLKRKGKLQYVELRALLRDVVEGLAYIHSQHYVHGDIKTANVLLSSDGKGKIGDFGTARTVQDGELLYVMQGSPLYMSPECMSAGEEDEEGNRIGYGFPSDIWSLGCVAMEMATNKPPFAHIKSIKGPAGLTNFITSLTDVPDLSPLFKCHPSIVEFVSACLNPDPSQRASAQDLLQMSLFSESTHGDRNSAVKALKRAQLLHVLKKFVAFQEPQEADKLKKRRNRPKVRRLTSDFFSSNSSPSDTASSGSARRLTSTAPLKSALAAEVEGVVGETRCQGATAAVAEGNEDESETDVPRHSDKAALAASGTSQTPDGARAARASAEASLSNTVTAAGSSLNLTASTFRRYLRKWDFSSTSSSSSAESNRRPKAMAPAAGGDGGAQRTPQRHCDPVTGVAGQNDKAEPDARNPNAEVAYELSPTPKKRSKTRSRPQTQLPLPVRSSSHQQRDRGSTTTITTNSTEEAFFATSSNSRSSSRSSNSGRTPNKAGSRNEAVGYTPSFPGRRRNVMLDEAGNIVSFDQLRSMTSGATLPDSKGEQHGVGVSAGRGAGVAAAATAEVTAPPRTPLSTLGDVNDHALSPSNAMGLVNASFAQPPGNFSFFNYSFNKNISFLGANMDEVLNSAANDFLNHLAANSHTNNAACVETVSSAGSAGQPSSRTLLCGERSGSGRSHAVPSSTREGEGHTDCTVVVTSPLAGAAHSEDCSSVTETPSRQRGWTVSRSPSTRSPLGVCGQGEPALIEGGNGVQHSGATLPRPQTPPNLLSMAATPAAASRSLYPVSSQLGSASYTSDDGTASITPRGDSVPLVGAAAPPHRRRRVRPPITNQSFFVVEDRSSVPFYGGAQTTSTLATPSNISSARMPGFSAGSPFSPAQISLTTLSSVASADGSITGGMAGDTNNSAMLQQHYASVAVVAPPPVFSTLSVSNARAMWQQRRRHRAAGSRGGGGGSSVSNFRPPAPLSSEGSVYLTAADTHQGDGQMRRAADAVGSCEGDDDDDLPSAAFGSMRSGFSRQSSLRSSPYLTAETLSATHEQDIKQRRAKGGDTATLSREDRRSADARDAPLFSSPTTEREPLLLAHLRHIEEALQDVLSQLQARQRQHIPQLRLRESSSPVTEVQDSFDCAPSSTAITAFQATLPQSAMQSTTLHNATLLPPAFASSASEVATIATAAPPQHSGMGIHIVPAELPQLLSSRTASVMIPPSKQGMTNPLAMRASPPLSMHRSNPLWPTEDCYATEVRDPVRHNSTEVSDTLLPPSVPGRSASSSGDDVTVEDLLHKVLQRVNLLLDEVSHLSPPVTSYSSPLTPTTTNASQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RME0</accession>
    <name>A0A088RME0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein kinase, putative</fullName>
            <ecNumber evidence="8">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_170450</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="8"/>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697736.1">
        <property type="nucleotide sequence ID" value="XM_010699434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RME0"/>
    <dbReference type="GeneID" id="22573788"/>
    <dbReference type="KEGG" id="lpan:LPMP_170450"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170010000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_170450"/>
    <dbReference type="eggNOG" id="KOG0198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06606">
        <property type="entry name" value="STKc_MAPKKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="674"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="89"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="189"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="559"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="226"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="559"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="702"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN97083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="986" mass="105595" checksum="76D031D9D5B402DF" modified="2014-11-26" version="1">MGGQRGSVAPHLPAVCSDRDVVAAAAKDRGSDDSEKSEESTPHLGSAITPIVALAFPIATRGESSNGSLAGVVTDVLPPLRLLASAESKLNHGAHSPTRPSLHKTLSSTASHHPSPHAPASYIKAPVDRVSSQALVMNPLSPTMIEASLPERKSSSGVTTSTKIGVDGAVGGWRAHCYAPTIPSNSAAAECEGGAGGGGVPAKGKTGNRLSKTPAQGVGSQRDDEPSSDEEGDDEDDSDEEDEESEEDDYDDGDTSDEDDENDDDSSADDDDDDDASMSASSSSLSTSTASTSAGDGKSWGKKRSSDKLKQHTAVVEKNAAVPSSPSECARWRGGPEPAAQLTRTKVSREGDVNVKVIFAVRSRHCFRRYVKEVMTRFGFQKATDFDMYCIDQYGDRVDIDTAEDFDQLLDAFTMTMTEGKEALGSSPCLHASSPPPPMSVAPLYHLCSGTQSTSGCRISSPVDGLNMNDHAHARAMSFSASYNNASSFYAARSFSLFPRLDATTTSFISTGGLVEDDGKSSGSVLRLYVRYSNAYYAEHRQEFQQQMQECPRYPQSVLSNGGSGTHWQQQLSLGSRSSKGQPQADLFPSSHVSPGETGFPFVRMLLASTGGSVSKGCGGVGNASSRDEFCAGYGQSEDWPGTSLESVSLQFSETLCSNLTKTFRLEEGQLVDWRRMSVLGKGSFGTVYEGITQDGKMLAVKVQELPLDDGEDAEAVKALKTEINLMRLLKHKNIVAYYGCQTRVLPTGNQQMEVFLELCHGGSLASLRRKFSKAKEPFSISLVRSYTRQVLEGLAYLHAQNVVHRDIKSDNVLISAMGEAKLADFGCSKRLGPVTLQAMSGAASPAPTPPETVVARTAMYQTIVGSPFFMAPEVLGEGGSYTGAADIWSVGCLVLEMLGREPWDITGTNIFQIMFRISREKGMPSGVPKKCPAVLLDFLERCFQRNAKQRATATELLAHEWVTCPDKALEEVPLSPLLKKEQLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMN0</accession>
    <name>A0A088RMN0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prolyl-tRNA synthetase, putative</fullName>
            <ecNumber evidence="2">6.1.1.5</ecNumber>
            <ecNumber evidence="2">6.1.1.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_181210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PRORSD1 family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="2"/>
    <dbReference type="EC" id="6.1.1.7" evidence="2"/>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97302.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697955.1">
        <property type="nucleotide sequence ID" value="XM_010699653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMN0"/>
    <dbReference type="GeneID" id="22574011"/>
    <dbReference type="KEGG" id="lpan:LPMP_181210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180015400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_181210"/>
    <dbReference type="eggNOG" id="KOG4163">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1350766at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.960.10:FF:000005">
        <property type="entry name" value="Putative prolyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="entry name" value="YbaK/aminoacyl-tRNA synthetase-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040285">
        <property type="entry name" value="ProX/PRXD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31423:SF3">
        <property type="entry name" value="PROLYL-TRNA SYNTHETASE ASSOCIATED DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31423">
        <property type="entry name" value="YBAK DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="YbaK/ProRS associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97302.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="719" mass="80724" checksum="7B59C7B76B1A9DE4" modified="2026-01-28" version="2">MSIEDCRGFDEVKALFQELRLDIPILHHDEKATVEEVLDLLKEKMGITAVGTKTLFLKSKKGDLVMATAFKSTATELKFIQNVTNTKDLRFASNEVLHECLAVVQGCVTPFPLINNTENRPITLLLDTSMAHSTQLLAFCLCRNDYTAVITFQQLKMYLEKIGYAYKLVDFGAASADAAVTDSTAALAAKPKRAAVAAATPAPAPSGETKLGIAARREENFSAWYIDVITKAEMVEYYDVSGCYIIRPWAYYVWKCVQRFLGGRIERLGVEDCYFPMFVSRSCLEREKDHIEGFAPEVAWVTRAGDTELEQPVAVRPTSETVMYPYYAKWIRSHRDLPVRLNMWNNVIRWEFSHPTPFIRTREFLWQEGHCAWAKAEDCAKEVLDILECYAAVYEQLLAVPVVRGRKTEKEKFAGGSYTTTVETFIEAVGRGCQGATSHNLGQNFGKMFDIRFQDPENNEQTLIPWQNSWGLSTRVIGVMIMVHGDNRGMVMPPRVASTQVIIVPVGITKDTTEEARQALLASCRQLEGELCEGGVRAKCDLRDNYSPGWRFNHWEVKGVPLRVELGPRELAERSLVVAVRHSCAKQSLTWNAQTPTAVAALLEDVQAQMYARAKETMETHRVRVTEWAEFVPALNRKCLILAPWCGAIECEDQVRKDSAEESRAAQAQEAREDARAPSMGAKTLCIPFSQPEPAESHTCICKGCTKAATTWVLFGRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMQ0</accession>
    <name>A0A088RMQ0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_171150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697806.1">
        <property type="nucleotide sequence ID" value="XM_010699504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMQ0"/>
    <dbReference type="GeneID" id="22573858"/>
    <dbReference type="KEGG" id="lpan:LPMP_171150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170017800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_171150"/>
    <dbReference type="eggNOG" id="ENOG502SFZY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267730at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="318"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="372"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="562"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="711"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="883"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="453"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="575"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="889"/>
            <end position="902"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="922" mass="96759" checksum="09EC04DA55AAB588" modified="2014-11-26" version="1">MPASRVHPGTMAMVVVVDVISPLAQKTISSSPTEASAVERLEIDVDVVPYTTTADMVLADVAVALQEKGLTMCISLQEAVLASGSVLPPLTWLQQAMGANDSSGSDRRQVSSTLSIECSYAVAVQHAQNSADSHQMLATAPPLRSSLVLHRGGDYILEDVERPLSQPTAVLSVVPRSMEATSSIAGRAPAQAAPPITSFLDVLTGPPASENGAVEANGAPRAPYALPPSPLRGGAPTTIASSAVSGGDLAPVSQYTTASVTVSKAITDVSRDVRSSMSSLALGSTAPPLLPPPPLPEKQPPVLVVALRHLQAQHAQVLAPDAQRHNGSPNASTSVAAPAEEQKHLQPTLSWAATEAAVQAEVECLQGERALTAKEEEGEASSAASRHANTSLDETAGGDTQSGGGRGRQDGETASGRFSQPQLRTQWLAAVGEEICAYQRETAVLRQATKKALQWRESSRQQLREEIARLEAEAAQRSAVLAERDVLRRRVGQLKAQVAAVKAAEVELLVTQRAAAVFPPVSAKDEHASRDLRASSSSVKSPRQCVIAAAAKAALESFRDASTSEYSDFSEHSPPRPPEPTSPPPPQACRSVPLVDVDGTGVSRSAHRWSGRRVPLLYGDTAAAPTASTEYPLREAQQRPSRSRTRLTIERSFLSSSLQAEVRAALTSDSESGSFVMDSLSDSAESAEAAGASGSGCGYAVTAVKGEAALQPPGAGVRRRRQRSTTTVSHIASGAASELLPASWMTVNAAAPPAAAAAVGATPFRTTIRTAPSSAHPVILSATSSHPYRGAQLRPLSSSFSCDGDSCDGGARQAFISSGASSDEAVEEPRRVTAALRRPSRDLQSHPSEGQRLREQVRGLREEIERVDEDVTRQGVSLYRQPRRRMARTRTGASGASRSATAPHHGLMNRHFAPAALGVDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMT7</accession>
    <name>A0A088RMT7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sarcalumenin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_190250</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Sarcoplasmic reticulum lumen</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Sarcoplasmic reticulum membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698020.1">
        <property type="nucleotide sequence ID" value="XM_010699718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMT7"/>
    <dbReference type="GeneID" id="22574079"/>
    <dbReference type="KEGG" id="lpan:LPMP_190250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190010900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_190250"/>
    <dbReference type="eggNOG" id="KOG1954">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="422720at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09913">
        <property type="entry name" value="EHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000635">
        <property type="entry name" value="Sarcalumenin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040990">
        <property type="entry name" value="DUF5600"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051943">
        <property type="entry name" value="TRAFAC_Dynamin-like_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43681:SF1">
        <property type="entry name" value="SARCALUMENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43681">
        <property type="entry name" value="TRANSMEMBRANE GTPASE FZO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18150">
        <property type="entry name" value="DUF5600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0703">Sarcoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="10">
        <location>
            <begin position="62"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="543"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="552"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00074933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN97367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="626" mass="69419" checksum="9CA37A5F01B3A0B0" modified="2014-11-26" version="1">MPVSEAPAAGPLHARESGGDVPGSMGTLIKKLYPLYTQRVQPLEEMYNFHIFRPSWYEETILNERPFVTLFGPWSAGKTTFINYLLQSNALWTGPQPTTAEFTVIMYGKEPGPIDGQALVNSKYLPFKGLLDFGESFINNLKGFQEPHSLLERVTLIDSPGVLESAKDIHQRKYDYVKVCRWFAERSDLILVFFDPSKLDAGAELRQLFQTSFKGIENRLRLVLNKADTISTQELMRVYGSLFWNLSNFINTTEPPRVYVGSFWDKPYNSNSFSLLFAEEKVDLLQELVEIIPQQAKDKKVASLIRRAKEVLVHAVIIGGIRTDLPAIFGKSKAKRKAVEQLPRRYELIGARYKMNHCDFPPVQAYKAFLERFDAEKFPPLKKPEKAGLIRGVQELIDTILPAMLRPVRDIRAANPFHEDERAGLLNMYRDRVLSQYDGRRDMQGSPDNVDSTKRRYLSNSAAQGPSPSVTAAPASNPSSLFGPSTVVTALSASPSFTGPPSLTVAASSTAATAAPQPQTSAATMPSLADMQSMMTMMQQLLANRQQQGQQHSSAAATTISHGKSFSSTPQPPANPAESSLPPSPQESGFDNELCPPTVMSPLGAPPYRAPEMNTWTDGDVLKQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMY9</accession>
    <name>A0A088RMY9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ATG8B.1</name>
        <name evidence="7" type="ORF">LPMP_190790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ATG8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97422.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698075.1">
        <property type="nucleotide sequence ID" value="XM_010699773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMY9"/>
    <dbReference type="GeneID" id="22574133"/>
    <dbReference type="KEGG" id="lpan:LPMP_190790"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000035900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_190790"/>
    <dbReference type="eggNOG" id="KOG1654">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264746at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004241">
        <property type="entry name" value="Atg8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10969">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02991">
        <property type="entry name" value="ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604241-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN97422.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="127" mass="12808" checksum="EF18415DC48AFF1D" modified="2026-01-28" version="2">MSAYQSSNTAEARRAECARLQAKYPGHVAMVVEAAKSSKAHLLALPRDATVAELEAAVRQALGISAAKVTLAVEGCTPAATAAVGDVADACKHADGFLYVSVRGEQAMGALLAGFAGPCFASDSGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RN22</accession>
    <name>A0A088RN22_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nuclear transport protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_180290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697863.1">
        <property type="nucleotide sequence ID" value="XM_010699561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RN22"/>
    <dbReference type="GeneID" id="22573919"/>
    <dbReference type="KEGG" id="lpan:LPMP_180290"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180007900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_180290"/>
    <dbReference type="eggNOG" id="ENOG502SA14">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267764at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTF2" evidence="2">
        <location>
            <begin position="13"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="363" mass="39027" checksum="66809FF84281C8A8" modified="2014-11-26" version="1">MTVDMSDTRLQSIGVSFAVHYYTTLVETPEALAALYVPSANVVHSFRKSNGAVELSSLLTSLTAEGVTRVRVEDVMSELAASGAIKITVKGQLIGTARTQSFTQEVELYKLAKDTYGITDDKLSYSAAGQTALAAETPLLKEAEESTVGTAVAVAEEETPAELAAVHAPATRKKPASFAEALRLSKVSEGAAFSNTAVRVSDKVKSTENREKATRKIAKVKADEKDVLQSAGSAKPKLTKKLPRATNSVVYYDIILKELPESITEEKVRAVVTPVSAVKLVNLVKSERRRRSKEAISEVITCAFVELERPANAAANHVKEVVAKLTELNKGMRIEEVREKSALAGSRKPREGAVATLKEEGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNE0</accession>
    <name>A0A088RNE0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_191160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698111.1">
        <property type="nucleotide sequence ID" value="XM_010699809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNE0"/>
    <dbReference type="GeneID" id="22574170"/>
    <dbReference type="KEGG" id="lpan:LPMP_191160"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190018900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_191160"/>
    <dbReference type="eggNOG" id="ENOG502SJ5N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265073at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="603"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="682"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="800"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="707"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="952" mass="101915" checksum="F18355C4C15B4C8B" modified="2014-11-26" version="1">MDAARAGGGHFARGPVSAGVSYAEYWQDLMATAEHAGQTIHADDSHEPVPAAKSPTPTPPPSGRAPPSPLAAASAYRLNLALTPNPHKVRQSPPPYQQQQQQPLHVTIMSKHVGEGEGEECIEKSMRRFKEVSAPAEKLTCKSSSARKSSPPAACAGPWVPSPSVLGIATRLSDDEAGTVQVTDSIHGQRVRVTVRGGTHTSENIFGDQRDLPAPSGDKDLVDSPHRYYSASDNTSAQHAFSLTAGAAPVDSAYAYTPDDLVVKAAQCYEQWRRCVMEGNTDAYDSDDSAWECHFSDGNSSMAGDDEAGGAVAAIRLADGPARESTEPPCAAARNHTSSALPHTPTDDRRSVLSSDRSDTLPDSSPLCSSAYTRRKRTPSPTAGTHSRLHSAEATTHGLTSGRRDRDGDTDSTITPAAALPSLFTWTHASPVAKYPSLHVAPAAPTVFCRFCAQEEKVVERLSGETVEKMRVERQGTHSHSAPLPPPQQQCYQHPSIQTPHCLHQEAGVHPGAATTAVRSESTHWRHMSKDIRTVHGAAGSLQSSSIAEADAVPLSFVYRRLFTDESEDGDGGVKVRLGFADARRRESSGAANSDGALVLAPSSEKEHGQLPSDSLGVSSASQREVARMTSSDPAHNLTALTEVNHLHETLIELSSCCSEDEDNNNPVVEGEGVDDEIASQAESTLPQRERTSLHGTALPSGSQCALVLPSPSHPSLRPSVEPAKSETQHRAALTGSGAHTTPVVAAKPLLCRDHPLWRKHHASVSMLYASRLLPSEQANDELQLFLCWAQEKAERQRRWRQHHHHGDADGSSETVLETSELGASPPVSCVVSGVHKVAYSTARRGRCSCAPSLQVQRSGLSGSNEREAVTGVLPVEFASAQATSPSSQQTPYLLRPAVYVASPLLNREEARSSSPPEERQWTITPSAAPSRFVEWIATEVDPYESLLLSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNG4</accession>
    <name>A0A088RNG4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amastin-like surface protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_201095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698309.1">
        <property type="nucleotide sequence ID" value="XM_010700007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNG4"/>
    <dbReference type="GeneID" id="22574317"/>
    <dbReference type="KEGG" id="lpan:LPMP_201095"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200050400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201095"/>
    <dbReference type="eggNOG" id="ENOG502SU24">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264682at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009944">
        <property type="entry name" value="Amastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297:SF4">
        <property type="entry name" value="AMASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297">
        <property type="entry name" value="AMASTIN-LIKE SURFACE PROTEIN-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07344">
        <property type="entry name" value="Amastin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="192" mass="21028" checksum="691F0AAF29D9DC2F" modified="2014-11-26" version="1">MELNIPLLLYAVVQFVAFIFVLVATPIGIFRVTKNHTIAHGVISLWGAKVDTGNSTLFDPISDFWSECPGHLLRFRLAEAFAIISIFVYGAAFVLGVIMLFCGSILRWICLGLNIVGAITVCIVWATMVRSYFNDDGKECPALQSVTVYGAGFALFVAAWVLDVINIFILLLSICTTVTTESGQVKQTEVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RP50</accession>
    <name>A0A088RP50_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_161590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN97034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697687.1">
        <property type="nucleotide sequence ID" value="XM_010699385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RP50"/>
    <dbReference type="GeneID" id="22573738"/>
    <dbReference type="KEGG" id="lpan:LPMP_161590"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160021300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_161590"/>
    <dbReference type="eggNOG" id="ENOG502SBF6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272126at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="113"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="451" mass="47648" checksum="04EB96D91EB795FF" modified="2014-11-26" version="1">MSVKETSITLPLAAESVLDVDNGITATSAISVLGGRAMLIGTSEGSILLCVSMNENARVLTPHSEATLHFGAIYDITISSHHLVATAGHDAVSCVFPLHTLYRDSGITQCRRITGHTVPVVAVRFLSDGASLVALGADGRVLMVEVRSGAVLTSLFCGFAATCLACSLDETQLFVGGRSLASIDLHHAMRPTYLQSVAVAAAGLDARASLSGTAAAFGDAVLPRAPAWLRLYAWEEKSEATVGASQWQFRTPPHMLIRSLDVDSGDGALSAVFARHVLGTTSVEVCGSARWAAAGGRTAFETTWAPQALRCVPTALGCRLSRDRSTSVAAKKLRVRCRVKVSARPSAKQTSTQPRSFLSSSVALWNGRWYTSAFELAGGTPRLAASDDFAGVSVFTAETSDQDGFPSAGPRTPGEELLIAQAQRDELQRECDALFFQIKSLLVHKAAARSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPJ5</accession>
    <name>A0A088RPJ5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNAj-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_205300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN98022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698729.1">
        <property type="nucleotide sequence ID" value="XM_010700427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPJ5"/>
    <dbReference type="GeneID" id="22574742"/>
    <dbReference type="KEGG" id="lpan:LPMP_205300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200059800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_205300"/>
    <dbReference type="eggNOG" id="KOG0724">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1690618at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000596">
        <property type="entry name" value="Putative DNAj-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000597">
        <property type="entry name" value="Putative DNAj-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054076">
        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044634">
        <property type="entry name" value="Zuotin/DnaJC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23082">
        <property type="entry name" value="Myb_DNA-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21884">
        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="138"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="573"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="312"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="579"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN98022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="653" mass="74483" checksum="E22890901A69EBB1" modified="2014-11-26" version="1">MQVLSIELPVLKSGEKALEWPQTQPSTGTDAVAADTPPQLSRWIEAYRVIPQGEAFCHTVALTTQLRHEDARMQKAQADPDVAQQWAAEEADGIAAGAGSNGANNADDDDGAGDSARYQFSSRKKKFVKLTDDDMLIDWYEVLKLEQQDGATDDQIKAAYRRRCLETHPDKQQNHSDELFKQVQRAFDILGDPDTRQTYDSSRPFDDAIPGEQVEVDAFFSTFGPVFERNKKWSSVPAMPSLGTDKTSYAEVLRFYDRWTGFQSWRDFSHLADLVEIDDTMPREEKRYYQRENARHLSHFHKEEQKRIRLLVDRARKNDPRLRRRREEEEEKRLKELREREAFRLQLAAEEERRRAEEVRKRKEREEAKMNAQQEEKQAMREAQTAVLDFFGQHGLLDETPTNKLLADCVRRPNVQWLFSKVANATEAQKLRDVLLACPAERRPRTSNSQTKDMEGDEEVEAVLRFNALIQKMEQHCGVNRYGEAVKKVQDGDATTAAAKKKEAAAVAAKAPVDAGPEWTEEDLSRLQKATAKYPPGTVDRWIKVCNVLRHRFTEEQAVAKVSELTAALHNAGSGNPTAAAASPSHVSAPSPAVSSVENWSLKQQKQLEQGLRDLKDYKEKDKFQKIAKMVESKTAKECFERFKFLCSVNKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPT2</accession>
    <name>A0A088RPT2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_203500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698552.1">
        <property type="nucleotide sequence ID" value="XM_010700250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPT2"/>
    <dbReference type="GeneID" id="22574561"/>
    <dbReference type="KEGG" id="lpan:LPMP_203500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200041300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_203500"/>
    <dbReference type="eggNOG" id="ENOG502S7W8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271988at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="282" mass="30658" checksum="ABE8140E402CFE49" modified="2014-11-26" version="1">MERRGEWVALLRSTLPQFTERSAAPLERRHAAAVLGPAPRRTLDEAASSLTAPCSLLLPYKWREEATQQLITTLHGIVPPPQVKQTDYFLCSLIHPSYVQADTMHCQSDSVQRRAQQELRRSVCMPLELTMTGCKSLRLLRELTHYVKQGAAAAAASARTASTLPVAQVGEKSEARGPSKGPSSRLSYPLDASWPELNSADTAAFLQAFRQAGLESLVLYDRSFFAASSTCTGADGAVPGEVSLAAFTALCGSIELVSGWSSLLQFVDRVAREQHGLRTQCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQ54</accession>
    <name>A0A088RQ54_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Intraflagellar transport protein 172</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_211180</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the IFT172 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698904.1">
        <property type="nucleotide sequence ID" value="XM_010700602.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22574940"/>
    <dbReference type="KEGG" id="lpan:LPMP_211180"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210016000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_211180"/>
    <dbReference type="eggNOG" id="KOG3616">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2186662at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000020">
        <property type="entry name" value="Intraflagellar transport protein 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000022">
        <property type="entry name" value="Intraflagellar transport protein 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001213">
        <property type="entry name" value="Intraflagellar transport protein 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:003404">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056168">
        <property type="entry name" value="TPR_IF140/IFT172/WDR19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056157">
        <property type="entry name" value="TPR_IFT80_172_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15722">
        <property type="entry name" value="IFT140/172-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15722:SF2">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 172 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24762">
        <property type="entry name" value="TPR_IF140-IFT172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23387">
        <property type="entry name" value="TPR_IFT80_172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="IFT80/172/WDR35 TPR" evidence="10">
        <location>
            <begin position="672"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="domain" description="IF140/IFT172/WDR19 TPR" evidence="11">
        <location>
            <begin position="1040"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="458"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN98197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1807" mass="200791" checksum="FA36F672B58E13B3" modified="2014-11-26" version="1">MQVQFYQNIMKGQQGTARTQAICFSPNNKRLAVADATRHIQLFDEQGERRDKFATKAASDKGGRGYIVTDMTFSPDSSLLAIAQSDSIVFVYRLGLEWGEKKAIRNKLSQTSPVTCVAWPNTSSQGVELIAFATLDGSVKVGMLKANKSHVLYSHDHPAVSMCTSRDNTKILTGHLDGTVYQYVFEASEDGAEVAGAKRLFVHSCAPYMLAWGESICAAGTDCQVGFYTPKSGHKPQVIPFDPKEVGSFTGGVCNPSGQAVAIAGREQIRVFDLNIRSRKWEEGAVVHLPHSEGFSAMQWKRDGSRLATGSVTGSVDLFDCCLRRYRMRGAYEFTYVSHSQVIVKRLASGTRLVLQSYMGFEIQKVNVYQDRYLVAHTSVTLLLGDLASHKLSEVPWQLTGREKFTFENEQICMVFNVGELCLIEYGKNMILGTCRTEERNAHRISVRVLNPLASDPGAGAAAGSGSAGGQRREVNTTTGSPIVSTSVAGGSGALEAYNSRCVIAYLIDRQTIQIDDLKSGVSIARVAHESKIDWLELDFRASRLLFRDKQHQLYLYHIATQQRTTLLSYCTYVQWVPRSDVVVAQSRLELCVWYNVESPDRVTIVPIRGEVEGMERGNGKTEVIVDEGVSTVAYALDESLIEFRAAMEERDLDRACDLLERTALTPGTEVMWCTLAKVSLQEVKLFVAERCYAALGDVAKVRALQRIHQLAAQARADSAGATTGYEHYTVLAELYMMNNDFKRAEQLYLENGRVEDAMQVWEEMNRFDESLTIAESRGLEDVANRRARYFAWLMETRQYEKAGEIREKDGKFIDAINLYLRGGTPARAAQVVSANNLKPEQQLLEAIAAALFKAQVFEAAGDFFDKLHMTDRAIDAYKRGHAFSRAVDYAKTAAPQQVVPLEEAWGDYLVSQKHVDQAINHYNEAGKYGKAVKAALDSRQWAKAAALLETQRNSGVGSSGAPADTAAPVDAATKSAYQRIAHHYEEVHQYAEAEKFYIKCGAVSDAVDMYSRAGMTDHMYRVAQRHLEQDKLVELFVSQAKQLETKGDYAAAERIYLKVNDADGAIMMYRKNRDYTNMMRLVQAYRSSYVVQTHLALASQFQKEGNLKAAETHFIAGKDWSRAVSMYRDRDLWDDAVRVAKVHGGTNAAKQVVVSRATVMDSEEGVQLLGKFNLVEAGIDAALESSKFDLALQWAQLAQPAKVPYVYLKYAMHYEDQGDFRMAEEAFIKSGKPREAIDMYVHQHDFTSAMRVAEHHDPSAVPHVCATNGRVCFQQGNYKEAEALLLRANAPETLLKMYVDAKMFREAQRVAKEYCPEMQGDVAKRMALNSNDPQKAGAVLEENGEYQLAIDTYLAATPEVVPDPATLANLWVRAVKVAQKHTRNLLKEVLRSATDKLKAVQRYVEAGKCLEDCEDYKGAINMYVQAHKFDMAETLAKRVSPELESFVKRAIVQDSISGGSMKDAKVVEEIDPEAAMKVYIGKGDFANALRMAARKSQEEVQYVVGLQVQHLLRQGDVVLCLEALSTNTMDADDFRFYETWMSVAQKAIPLLPGDDAVATLLQPLHDGLVKVIDSMTRSGQKTEDIAKATALATVVHIYYMSRKMETELNMPDFAVQLMLGLPRWIPYVAPDKAFYDAGMAAKRSGLEGMQDVAFLYLNRALDISERIDDGDADSSGIDNADFAATDFPKVYRLPKEPTVPAQAMEEVNNWVLTVSIDNTAASDDRTLPMVNDPENGEPMFAGSVKSPHTGKVFPSCLVTGYPVMDGGLTKCSHCQRQANQADWNRFVLMAKRCPWCGAAANPDFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQC6</accession>
    <name>A0A088RQC6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_191120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698107.1">
        <property type="nucleotide sequence ID" value="XM_010699805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQC6"/>
    <dbReference type="GeneID" id="22574166"/>
    <dbReference type="KEGG" id="lpan:LPMP_191120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190018500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_191120"/>
    <dbReference type="eggNOG" id="ENOG502RZ4R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="255846at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="CDD" id="cd23090">
        <property type="entry name" value="mt-LAF7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="19318" checksum="FBAF424067280EF3" modified="2014-11-26" version="1">MGGIKGGVGSFLLRRTAAKSIRQKHFTGPQFYKRKIFNFPIGHHQLHRRVAPALQTGSPTHQLEYQRYAHLPGDARTRPSEDFTFSRATSPHSSGRSRERVDKAMYAWAKRGSLQLYQMGGKRETFVCYRCGYPVRSALVAIKDDNWDYRMCYSCYTKTVDTGMERNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQF6</accession>
    <name>A0A088RQF6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mitochondrial glycoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_210040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698792.1">
        <property type="nucleotide sequence ID" value="XM_010700490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQF6"/>
    <dbReference type="GeneID" id="22574826"/>
    <dbReference type="KEGG" id="lpan:LPMP_210040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_210040"/>
    <dbReference type="eggNOG" id="ENOG502S8UC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="258061at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036561">
        <property type="entry name" value="MAM33_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54529">
        <property type="entry name" value="Mitochondrial glycoprotein MAM33-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="255" mass="28014" checksum="E8F1940687BCC8E9" modified="2014-11-26" version="1">MSLFRCTVRRLCGSTGPFLVNSVASSSRMPPHNLKLSHVLGTRQFSLFGVSMNHSKLLVQCTLSSPFYKRDSRSRAVRRRGKVNVLGSIEFECQLSNICRGFPLVLGLSCATRGGLLVINGAIFSPVGTTVLEGPELASSQFTYQGPHMNQSHLAEVAIGRRLHRSPLDDIAHIEAAFFSTTDCFGSSSRTWFGHTPVHTVKPELVDSIAKLVGAFGIDDTLAEYVEWKARAVDKAERDAWINISNVLLPNLEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQQ7</accession>
    <name>A0A088RQQ7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Proteasome regulatory non-ATP-ase subunit 11, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_200670</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698266.1">
        <property type="nucleotide sequence ID" value="XM_010699964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQQ7"/>
    <dbReference type="GeneID" id="22574274"/>
    <dbReference type="KEGG" id="lpan:LPMP_200670"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200010900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_200670"/>
    <dbReference type="eggNOG" id="KOG1555">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="527244at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000026">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="7">
        <location>
            <begin position="30"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN97559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="309" mass="34666" checksum="15A491DF31877103" modified="2014-11-26" version="1">MDPSAFGMMSGRGMGRQAEVRDARDTAETIQISSIALLKMLIHGRAGVPLEVMGLMIGEEIDDYTIRVADVFSMPQTATGQSVEAVDPEYQVHMLDKLKLVGRHENVVGWYHSHPGFGCWLSSEDVMTAAGYENLTPRSVSVVVDPIQSVRGKVVIDAFRTIPQEIMAMRAMGEYVEPRQVTSNIGFLSKPSAVALSHNLNRQYYNLPVTFRKKNHELRLLLNVYRKGWQEGFKLEKAKVYQRETRASIRELISLSKQAEKYITQGRDEDDLGNVGQINTMSHLQTEAENVIHRNLNQSIGAMINAVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRA5</accession>
    <name>A0A088RRA5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">rRNA methyltransferase 2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_230570</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699215.1">
        <property type="nucleotide sequence ID" value="XM_010700913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRA5"/>
    <dbReference type="GeneID" id="22575261"/>
    <dbReference type="KEGG" id="lpan:LPMP_230570"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230011400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_230570"/>
    <dbReference type="eggNOG" id="KOG1098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20105at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000563">
        <property type="entry name" value="Ribosomal RNA methyltransferase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF18">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="7">
        <location>
            <begin position="33"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN98508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="285" mass="31359" checksum="064A285FE3CF5F5E" modified="2014-11-26" version="1">MRATLACWQGTSRQWMQRQSQDPFVTKARQDGYVARSAYKLIHMDDRFHLFDRQHTRIVVDLGCSPGGWCQVIRERAGDRCFLLGVDLLPIKAKIPNAVIVQGDFTEAATEEKLVKHLAHHSATLGRTDTVTAAAASPASCFTGVDIVTSDMCPNRMGGSQDRQRIAQLNLQAINVCAPLLRTGGHFVCKVLGSRAAYEELWCLLSRLFLTVHTCKPPASRMHSDEAFLVALGKLAAPRPASFTTRSCASRAAMSKANRDNGGGSHFGLDDWPGFCRAGRSQRWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRT8</accession>
    <name>A0A088RRT8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin-conjugating enzyme E2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_242100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699549.1">
        <property type="nucleotide sequence ID" value="XM_010701247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRT8"/>
    <dbReference type="GeneID" id="22575619"/>
    <dbReference type="KEGG" id="lpan:LPMP_242100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240028300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_242100"/>
    <dbReference type="eggNOG" id="KOG0421">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253686at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23791">
        <property type="entry name" value="UBCc_UBE2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000117">
        <property type="entry name" value="Putative ubiquitin-conjugating enzyme e2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="9"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN98842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="155" mass="17107" checksum="7A742A00B4B231B9" modified="2014-11-26" version="1">MQGGGNNSGAAARLQKELVEVMMSDAEGISAYPEDDNLFRWIGSVKGVPNTPYEELEYNLLLVFPPNYPYEAPTVTFMTPCFHPNVDTRGAICLDILKEKWSAVYSVSSILLSIQNLLNNPNNESPLNNHAAQLWHDREQFTIAVRTTHGGAPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RS98</accession>
    <name>A0A088RS98_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_241220</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699462.1">
        <property type="nucleotide sequence ID" value="XM_010701160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RS98"/>
    <dbReference type="GeneID" id="22575531"/>
    <dbReference type="KEGG" id="lpan:LPMP_241220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240018400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_241220"/>
    <dbReference type="eggNOG" id="ENOG502RM2Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="436852at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050680">
        <property type="entry name" value="YpeA/RimI_acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43420">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43420:SF12">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="7">
        <location>
            <begin position="169"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="79"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="621"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN98755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="669" mass="71617" checksum="8DFFDEAB634FA3B1" modified="2014-11-26" version="1">MVRSRGGRGRGRGGRGRGAAAVPKDDPGGERASPAPSTLEASQLSAPPAVPLVVVVPQGRMITRSLLRCTASLLLDDHSNAASSPQLSPPSGRRRRRTESAAPTTSTFAHTLPAPRESTPGSSALASTRISSAFSPATAMAGDTTATADGSGGRFSALSQRVVIGGLLRCICTAFLVSPSETLLECSRCRNWCHPACVGVDYEELRLHQRQRDFLCPFCTETATPASASTSLPYTAATSLPTTPHILSPPSPGSQIPASITTSLGESIKVVFSPVTPPAVAQMRAVPADLADSTTAAAVSTPVKSVAVAQTGGGRCIGYSTVAAMSAPPALPPPPISSSPLSSFPLVIPQPPAPRQPPLKLREVPDKSPPAPLASELQCLIRTVEDTAHQMGYKMLHLPAHKLTEQQVAECLECCTEAIHDATFSADYPAYCLREVQNCRHPYVQGTVLQSQADERICSLILSSGRDLYGNLKSTITQLKRSLQRGLLDTSALTPFMAECMAIVDVADFVHITLSATHVQHQRKGLARLLMTMELLKWSLRGRNRAFLNMAIEKRLVDFGSRIELASPAASKRLYESFGFVEVYPRYDPVTGKERWTAKEADMGRVMANLNFVDHVRSVAESIPAKHNPSRSSNGDDMGHRGRRHKAEREPPSSVVIEAGGAWTRARKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSD2</accession>
    <name>A0A088RSD2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquitin-conjugating enzyme e2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_241680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699507.1">
        <property type="nucleotide sequence ID" value="XM_010701205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSD2"/>
    <dbReference type="GeneID" id="22575577"/>
    <dbReference type="KEGG" id="lpan:LPMP_241680"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240024100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_241680"/>
    <dbReference type="eggNOG" id="KOG0420">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10249039at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23794">
        <property type="entry name" value="UBCc_UBE2F_UBE2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000123">
        <property type="entry name" value="Ubiquitin-conjugating enzyme e2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="1">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="192" mass="21580" checksum="13A03719FA9A274F" modified="2014-11-26" version="1">MSLARLTRERKQLLEAQQFSGTAPSTSANTTAASVSSFNAAQGRIRADMQKLDGVMSEVKMDSMDWYVVHVSYTPVRGIWQGGTFNFRLIFSTDFPYSGPKVRYTGPRRIFHPNIEGDDGKKDWGVCLGMQTEWRPTCTIKDMVVAIEMLFALPNYDDPLPGVAKTAAQVLKDEPSRFELIARRWMGGDYIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTM8</accession>
    <name>A0A088RTM8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_261420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699962.1">
        <property type="nucleotide sequence ID" value="XM_010701660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTM8"/>
    <dbReference type="GeneID" id="22576045"/>
    <dbReference type="KEGG" id="lpan:LPMP_261420"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260019200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_261420"/>
    <dbReference type="eggNOG" id="ENOG502SFEM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273734at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="361"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="751" mass="81932" checksum="BB80098BC7D0E544" modified="2014-11-26" version="1">MGSVCSSGEDARHHRENHKNRINPTETYDKWQQKMLLDIGADPLAVIRDFPRMTVFVHTNTSCHSLQDYYHPINDCTDAALNRKPQQQKQPRLQSPINPLVPRNRSQSHPNVGADAAEHGVGGAAGMEGESRQQQRRRKRMEKCSSSALHMDTSTGAKVNANASVAWTSPTASPLLPPRSPSNLMPHGSTKSQRPSRQELSLGDDVFAARMQRVRDAVLLLSELCNERATFGASFESSWDRLIMHGSGGGRGSNAANEPTPEPTHHSRPPSSAKQVRKKSITLDVHQILLNACVDSGMLMLVEETNSAPTLASPLLGSAQPRLGASALAPLSLQPCTPPGLVSHTFQPNTSSASGLQPGSANTTTELTAGGATAPNHSTLSSDHPPMPEAGDDWQQRNRGPVASASGRYIVRSATFHLMQFTTQGVMFFPVQRLKHILWMPWSSHMQDVAWMIHFHVVEATPENLAACKQHHPNTLCNTPTSLLSPHADSAVEAVIATVAGVYGHRNSLSETRALKGGTADAEGGKLPAIADGVRNGKLILIRHIQTGRHYVVDSERKTTPRYELDWACNIVLDQDTLLKVFAPYQEYAAAARDAAAAAPSAPLSSLRNPTVAQKKTTETAYSALHAHQHPCDNSYETVNGDAPTSDTTSDNVAEMAFPRRPVAVPATILNPELLTLDFGVRAAQQPLLLRREVVCASVEVLAARMEKPPHTLFMVSPTWCKRKEELDYVLKQQYRVQLAKVNELPKKMLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RU57</accession>
    <name>A0A088RU57_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_241570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699496.1">
        <property type="nucleotide sequence ID" value="XM_010701194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RU57"/>
    <dbReference type="GeneID" id="22575566"/>
    <dbReference type="KEGG" id="lpan:LPMP_241570"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240022800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_241570"/>
    <dbReference type="eggNOG" id="ENOG502SZCQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266948at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="66" mass="7325" checksum="C0911CDFD1AF3707" modified="2014-11-26" version="1">MSRSQEINDSAAEAMRRADNADAPEYWAEVPHPESCTAAQQQQLLNDAAAEAMRRADVAYTKDDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUI2</accession>
    <name>A0A088RUI2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_250700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699641.1">
        <property type="nucleotide sequence ID" value="XM_010701339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUI2"/>
    <dbReference type="GeneID" id="22575718"/>
    <dbReference type="KEGG" id="lpan:LPMP_250700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250012600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_250700"/>
    <dbReference type="eggNOG" id="ENOG502SKC6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273579at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="710"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="781"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="710"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="793"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="820"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1065" mass="114281" checksum="C2FAB99B0E7149F3" modified="2014-11-26" version="1">MSSAAATHLQRLLDGYVSATLDCHGRKLLPNGNGAYARNSHTLALDAAEVMCYLPFFSTAFDASGGGIASRRSLHLDPSQLFVAATGPTTQPTVDGARSSDALSSFILYLGDVVERHLHAFMSAVSVGPPFTTLRFAVELRHGSASDGRSNNESSTHDRSASERGYRGGGGPYVNFVAWVALEVYRLLARGAESRQCERRAAGGATSVDAGVRTDAYVRWEREIGERVSAAMATAQKLEATRTGCSDVRWDNALRAVSSATDARLDDVFATYPHFFYLFMCTELLPDLQLRLHRCDEANCNAPPLVRLRQALRSTAVAEPTDDQSLTHPTPFLHTVFWEDAVSLLYCRSTGSAPVMGPETTMRSDSGFTRIATTPGQTSVFVVAAVASTLAVPLLRPACRWIDRFAHLSSTAEAHSQRPVVVEEEQNRAQAVMHILDVCMRSMQVVPFPMYDSCDADMPLSLGSSEMAGSWLIPSTSSPLHVRSMPLFGLRRQRRAVVLPGLSIAATRIRSLAAAYSGKVSTVDTATPDMLVPAGTCVWSPAGALAQVSWTEAQLSMSAVAPCCDDANAPFTSISAVPASNLHPVELFLLFEDVPSDAAALGRLRAALDAEVCEGWVVLVVQASVPKATQQCVESTWGTDARPVLLLSGLGWWGLQQLALRFNVQPNTSATDAHCLRGVRRRLHHDSGADQPQERRGCGVAALPLHGQQYAPSSSLSADDGVQNQLPEKGYSRHTRYATAFVEGREHYLFVVGECTDGVEPSTSSTPTGMKSEHTAGAVADPTGTVLSHAPPTSLPLPPSRSPLSPPTMSMHFCDDSEESSSSSLPHRSSSSGSTFSDATAAAAMTADGAGGEVMRAWDGDAAVPPIPFVVVSVLVGAATRGTQQELVYDIGYHWRLLLHQLVLPEPLCCQVPTSGERGATAMAIRKLNSVLQSPLPSRFASASPAWVPTSVYTPEQLRALGALRDALFSYELLSLQRGPEGRTLDESWQELERYTEPNTSPYEGCSEPPTESWLAIQSAYLAVANCVDELCHTVVLGGGDGDTSANNSEPRGSARRDLYFFPVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUK9</accession>
    <name>A0A088RUK9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ICAM-like surface protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_272060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700292.1">
        <property type="nucleotide sequence ID" value="XM_010701990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUK9"/>
    <dbReference type="GeneID" id="22576384"/>
    <dbReference type="KEGG" id="lpan:LPMP_272060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270028900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_272060"/>
    <dbReference type="eggNOG" id="ENOG502SF6I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273163at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="39783" checksum="4A8250B52FD2F6CE" modified="2014-11-26" version="1">MGQQRGKKAAPSKSAAVDATTSVLDPSPFFSLGCATFTDAVAIAKVVSVVLPQHHLRDRSILHATLLKKLLHRTYEPSAEDLAQQELSQQEAHNGGKPDHSAHSSLDSYAAPTSPSSSSTPYVIVHIKSAEVHADTALQVNPRGDVQVNIMVTLVAARLQHGICAGVSEASPFTSCMQVRVPTVAVPAAVAARGNADDVAALLLGGASVSGTDNVSQEDKEVEPSSGDAAVNASTPAAAAAAAAAKHKCRTDIPENEQLRVTARCLEDESIVPGQAVLLISEPAAMRCIGIRPPRAAPGPFFFTERTPPSAQSSSGAAADEAEATPKRRARKSRASAGGTYGARPARRIVAIECAIPERGGEGDAAAGIRKGSHKRPRTSLNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUQ9</accession>
    <name>A0A088RUQ9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">P27 protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">P27</name>
        <name evidence="2" type="ORF">LPMP_281050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700445.1">
        <property type="nucleotide sequence ID" value="XM_010702143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUQ9"/>
    <dbReference type="GeneID" id="22576550"/>
    <dbReference type="KEGG" id="lpan:LPMP_281050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280016000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_281050"/>
    <dbReference type="eggNOG" id="ENOG502RTR3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="255809at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="240" mass="27473" checksum="ECB500F3FCD88FAF" modified="2014-11-26" version="1">MSRCTGRMSGGVARANLVDHGVYLKPMSLNPFLGTVHDGTSTGYFQGFSAKPIHWLYRFRYNLLPQGMSGGFFSRNPYGRFVHWLEVSTIEKIRLQLQTVESMPVSVMTAIVVLYSVWFSYRLTFLHPDITLYNLVLWSTKPWVQQQRFNKKINIDQQVYRWVHRVPEFNSNDPIREIYKLGVGANDPYLDHVRGMGREKELILYEHERRGGAGSILPLSVPHEDHSGHNPAPLTAGQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUS9</accession>
    <name>A0A088RUS9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tim10-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_251610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699731.1">
        <property type="nucleotide sequence ID" value="XM_010701429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUS9"/>
    <dbReference type="GeneID" id="22575809"/>
    <dbReference type="KEGG" id="lpan:LPMP_251610"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000048600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_251610"/>
    <dbReference type="eggNOG" id="ENOG502S4KD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268856at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="102" mass="11490" checksum="DDE1315A99EAE113" modified="2014-11-26" version="1">MQPVQPNPSLMGLSQSEAVILSEKLYHISNEGFMYCAEKCITHYGDDAIPYHPGEKACLDRCTHKVRNGMDMAVAQKKEFERLLRSGDLPYQWMKDAAAGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVI5</accession>
    <name>A0A088RVI5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Guanine deaminase</fullName>
            <shortName evidence="7">Guanase</shortName>
            <ecNumber evidence="3 7">3.5.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Guanine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_290880</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>guanine + H2O + H(+) = xanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:14665"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Purine metabolism; guanine degradation; xanthine from guanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.3" evidence="3 7"/>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700696.1">
        <property type="nucleotide sequence ID" value="XM_010702394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVI5"/>
    <dbReference type="GeneID" id="22576852"/>
    <dbReference type="KEGG" id="lpan:LPMP_290880"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290013000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_290880"/>
    <dbReference type="eggNOG" id="KOG3968">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="UniPathway" id="UPA00603">
        <property type="reaction ID" value="UER00660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008892">
        <property type="term" value="F:guanine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006147">
        <property type="term" value="P:guanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000070">
        <property type="entry name" value="Guanine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014311">
        <property type="entry name" value="Guanine_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051607">
        <property type="entry name" value="Metallo-dep_hydrolases"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02967">
        <property type="entry name" value="guan_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271:SF6">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="8">
        <location>
            <begin position="68"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIO00039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="454" mass="49530" checksum="7AC1D148BCC678FE" modified="2014-11-26" version="1">MPVQAFVGTIFETSDRNTLNIIQDALVVVQDGTIEQVINPATDAAAYARAAEEASAAGHLTRLKKGQYLIPGLIDVHVHAPQWPQLGTRLDMSLEMWLQQYTFPLEARYKDLEFAEKSYSSLVSALLANGTTTAAYFASIHVEASVLLARICLEKGQRAVVGRVAMDLADQCPEYYRDASPQESVAQSETFVQQVRALKGNTDGLVLPSVVPRFIPSCTDEALRGLGELAKRYDCHVQTHCSESNWEHNYVIERYGKHDALVLDSFGLVTRRTVLAHSNYLSTEDMQLIKERGAAVGHCPLSNFYFSGAVFPLKKALSMGVHVGMGTDISGGPSASLFDACRHALTAGRALECGTDPCLSATERSQHRGARVSSVEAFFVATANGGISLDLKVGRIAPGYMFDVLVIDTTLPKSSLMVFEGIDTLEDIFQKIVYTAAPHNIVQTYVNGRLVSQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVL7</accession>
    <name>A0A088RVL7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_261970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700016.1">
        <property type="nucleotide sequence ID" value="XM_010701714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVL7"/>
    <dbReference type="GeneID" id="22576100"/>
    <dbReference type="KEGG" id="lpan:LPMP_261970"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260024400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_261970"/>
    <dbReference type="eggNOG" id="ENOG502SB97">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267434at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="678"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="492"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="583"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="715"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="727" mass="77795" checksum="D19FB316577C866F" modified="2014-11-26" version="1">MADFSKRQWRALAEAYPFYPSGEVSVGSTAEYRALDCQAALTHSEIEVPPLSSSEYFVQYVVPRVAKVFPEELQAYERGGGYSDQQGNFNGDRLGPVSPWFAIEAVDALLVYLFGCTTSALLQSSSTKQRRAFATTCFAPLITPLSRREQQLLGLYYRKQEQYTYVLSTQRQLLAASQLAVRALQGASGSILADTQTDVSAPQRGAEESLAASTRESLVVVGSQKASSWPPLAHATVSGEGTSARILQVSSSSRAPAASNVKGCEANSTFTSALANIPYETCPLGTSAAAALLVDTPSVAGTLCDSPFRHARTGAASPLITMGCCAGCHEVGGDLLICTQCGEVRHEACGGPHPPEPSKVDGRMPTVNVCRRCAKELNLSSSSSSLRSSTSSSERAELGEYFSDDNEGSSLSGFVVNTSDEEEEAEEDDQSTDDDSSSDMDRARDDEKHERQVEKHWPENASLPSWKGQHAGKDKRRGSAAAATVAPSEVMSASSSSSGSSRIWSRSASLDRALAVAAKKRNKKHGSLKKVYTDDGDYGVGGSAPRTEGRKGQRRKRRHENSEGEEDRRRQHKRKDPNDDASDASSSVRGASSVSLSLSTEKVRCLKAGGKTASSYSHTSAQTPPSPLRKEHSRWVDPPANREGRTHSPANRRSAEALLAQPCRVMALEDEEELRTLGIAASSGSGSLLQPPLPSSKQRHGDIVNRSSGRKSVMNIASSSSSGDDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RW14</accession>
    <name>A0A088RW14_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="14">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LPMP_292320</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="14"/>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700836.1">
        <property type="nucleotide sequence ID" value="XM_010702534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RW14"/>
    <dbReference type="GeneID" id="22576995"/>
    <dbReference type="KEGG" id="lpan:LPMP_292320"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290025400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_292320"/>
    <dbReference type="eggNOG" id="KOG0944">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="361536at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14298">
        <property type="entry name" value="UBA2_scUBP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000094">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000744">
        <property type="entry name" value="Ubiquitinyl hydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033864">
        <property type="entry name" value="UBA2_scUBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016652">
        <property type="entry name" value="Ubiquitinyl_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041432">
        <property type="entry name" value="UBP13_Znf-UBP_var"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF10">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17807">
        <property type="entry name" value="zf-UBP_var"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016308">
        <property type="entry name" value="UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 14" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 14" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7 14" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="17">
        <location>
            <begin position="152"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="16">
        <location>
            <begin position="303"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="15">
        <location>
            <begin position="611"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="710"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AIO00179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="751" mass="81939" checksum="7F2EFC0FDE4A49EE" modified="2014-11-26" version="1">MPFPVAHEACPHAWNESAMVSPFPGMMVHRDECAYCCRSCCQGDGVYVCMACHTGLCCEHLEKHMTICETHVMYTTIKELPAKETDEVKDVNYLGAGAPKEYETAVCCADCQVQFAQVPELAVEACSGIINAPEPGAQDSTAGGDVGRLQKPQCPHLVCLEQLPSPFHVHPPTSDDMCSAEACGCHVNNWMCVTCGAIGCPRPEAGGKGHALQHYELTGHPASVKLGTITAQGADYYCYACDDDVDDVHFTAHMAHFGVDVHTAKKTAKTMGELEYDYSSQFDFNKITEAGASLTPYYGPGHTGIKNIGNSCYLASVVQCLMSLAPFQRFFFPAKSTPHQAQCTADPYTCHHCQTERVAAGLLSGEFSREGHDLTNSICPRLFKKVFAKQHPEFSTGAQQDAQEYLLYLLEEMQRYVRPNVNGSAGAGGAQQPVHPSEIMEMVMEHRIECSKCHRVRYTYEKDKCLSLPIPIDPMVASTDAAATSEAEVLEVEVDAIRPRCSLEDCLRVATLPSSIQCRCEVCGESVTYSTVTRLASFPDVLPVCIRRTYFDIATHNTKKMDVYVEVPQELELEAYRGTGLQPGEVPMPASSATSAQGPRADAHVAAPLQEVDEVALVSVVSMGIDIDVARYALIQTNMNIERAIDYIFSHPHIADDVKAAPPLHSEEQQLTPTRAATAVSVPKSATDGTASYELTAMISHMGASARTGHYVCHIKDAATGKWLLFNDEKVGESQNPPFSLAALYFFQRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWQ8</accession>
    <name>A0A088RWQ8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_280180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700361.1">
        <property type="nucleotide sequence ID" value="XM_010702059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWQ8"/>
    <dbReference type="GeneID" id="22576463"/>
    <dbReference type="KEGG" id="lpan:LPMP_280180"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280006900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_280180"/>
    <dbReference type="eggNOG" id="ENOG502S5JU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277869at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="156" mass="17460" checksum="6C0C4820881D5013" modified="2014-11-26" version="1">MLGMLDKERLGHNGLFGLLAGGVIGQYEHLIPRIFGPLTRHITPCLLALGLQQLLVTPLILWSYFNAMTAGRGGLSDPSFMREHSFGAHRRHDLASVERHILYDVMPYPLLVSWGVYTPLFILAYIGQHRASTVLSCCLHVPWCGLLSHMQKTDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWR2</accession>
    <name>A0A088RWR2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_280230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700366.1">
        <property type="nucleotide sequence ID" value="XM_010702064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWR2"/>
    <dbReference type="GeneID" id="22576468"/>
    <dbReference type="KEGG" id="lpan:LPMP_280230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280007600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_280230"/>
    <dbReference type="eggNOG" id="ENOG502SJCC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="260055at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="274" mass="30023" checksum="06107667790B8E6E" modified="2014-11-26" version="1">MVTGPHEEAIATASLEKDYDDEHLLQSSAESWVELNPAELGASPETQHPLTDMSASTRMVVVAQPFALLSSALEDAEENRSLEELETQDEVAPCLPAPQEPSYTLPSVNEEVGVSALTRLLIGETKASTEVTEQKPRSSFSSRAADMNDDLASVDDDGAQVRQTVCVDPDSETSISELKVSANSSPMVGITEMLHRRVIQEDLLRTERGPSELPLEERMAVIHALFGDFGDAPISAEKFREVMVPYQRHCECLGASYGFHHQSCRFFADFPVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWU1</accession>
    <name>A0A088RWU1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_301910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701216.1">
        <property type="nucleotide sequence ID" value="XM_010702914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWU1"/>
    <dbReference type="GeneID" id="22577244"/>
    <dbReference type="KEGG" id="lpan:LPMP_301910"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300023400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_301910"/>
    <dbReference type="eggNOG" id="ENOG502RZ8C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272086at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="264"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="440" mass="49894" checksum="B8F17CEA6FA3AA5E" modified="2014-11-26" version="1">MDSPSSAPSVPAALPETDEARLLFYVEVLMANVPLLIADLSSAKYAFLSFSEKTRREVKQKSTLIQFIGRTFTSLQNANKSLIATQQSLREYEMKLVRAAPPSFVTSEEALRLSNTTANGDTPTAELNGSASPAPAETAAAESQRFLTAFPDNVLILSEEDIRPVREVEEVYEKESTAYRDAAKACNAMEDAFEQAQDRCRTMTEHVQDLKWRFQEVYSGWKSAEQERGMVRIMRDELAGRRAIMTEALHEIKTIKDECYAKEFRIIEDSIAQAQAEAESIKAELQAKRCRYELELATYQIAYKEQQAEVESLREQLKLLRTHQRDLEMLAKKQQLEEMDRNCLRKLVMETLTLTPSKYGKVDDRKLTPEQEAQVRSDHPLVSVLAARISVLEEQRKTIGRLLTSARGMRKSDAVSVTVEQIRTLLEPEIQLDEEALACE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXB9</accession>
    <name>A0A088RXB9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_312100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701598.1">
        <property type="nucleotide sequence ID" value="XM_010703296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXB9"/>
    <dbReference type="GeneID" id="22577636"/>
    <dbReference type="KEGG" id="lpan:LPMP_312100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310027900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_312100"/>
    <dbReference type="eggNOG" id="ENOG502S3JZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250458at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050693">
        <property type="entry name" value="Hsp70_NEF-Inhibitors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316:SF18">
        <property type="entry name" value="HSP70-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316">
        <property type="entry name" value="PROTEIN FOLDING REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="462" mass="48740" checksum="DE46F9CEFD932992" modified="2014-11-26" version="1">MSLDSGVNAALLNLCAQLQDGGTANTASEGPSALHCAGGSGEMVAQPSPSASAGAATPAPAPSTAVGETARPASDYEWLRNALASVEAPEKRVKQLLFNMENRTTEGEPGPLTPEEQLEALAELADMVEDVNWAAEFALMQGPQRLLQVLRHASAAHPLLSISGRGAAAGAEASKSTDAETKEESLATPDSTPSSVLPFFTALALVIAHSAQLNAPVQAAYQAAHWEDTLPHFMGDCVKAVQALLLLGSDRQAAGTRGNSTEAANVVTRATSLMRLLGAVLHACSCLCRDYPPNTIVFLQSSGLAVIVDTLRLTRTLLEIVLGCTRTDGGAPAIVTHISSGAASDEEADDIYAPLLGTAHKVTARAFFFVTYLASAGVSSEEVIQLACLHAESCNSNETIQKAAARALTELMAKSPNVIKEAVQTLMPHRLKEWRTHLQRTVGDEEMEDERRHFVDVFDKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXM8</accession>
    <name>A0A088RXM8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_290840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700692.1">
        <property type="nucleotide sequence ID" value="XM_010702390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXM8"/>
    <dbReference type="GeneID" id="22576848"/>
    <dbReference type="KEGG" id="lpan:LPMP_290840"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290012600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_290840"/>
    <dbReference type="eggNOG" id="ENOG502S22K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271018at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="391" mass="43353" checksum="4D502F1E6FD74ACC" modified="2014-11-26" version="1">MSCEHIDPNDFHSPAANQYTLNCLEELARSPKFRSYVRHVEYKERFYLTWFLAPFTLFGILYYHLVMFGEEGINLFTDQSTRSSVSLSAPPAGMVAATMLMLLFAVPCIVIAPFVGFFEEPHRWQSLVTLAFLTLVNMTIVSFGGGRLHYPPFVTTVPPVTELIVSWRPMDVAVVLLRDIFVRRALCLQGFLLAGCAVAFWQSSFWDRTWHPPLPLVTIPIAVGLSGIGWWMTVQKAVPLFLTADGRPTPVAEGLHWSVVQSDPAGAASLCLTVVKEIFRQVVRDAAPLWQQPQLPMVLQNPSSCVSLYLAAASMTLVHVFILLAKPVVDFVFGAFFFVLPTDPTLWGLALIGTIGGAVTLWRMNDGLVYAPHIVVLCAITFSLLLNGFCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RY24</accession>
    <name>A0A088RY24_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein kinase, putative</fullName>
            <ecNumber evidence="8">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_292180</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="8"/>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700822.1">
        <property type="nucleotide sequence ID" value="XM_010702520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RY24"/>
    <dbReference type="GeneID" id="22576981"/>
    <dbReference type="KEGG" id="lpan:LPMP_292180"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290023900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_292180"/>
    <dbReference type="eggNOG" id="KOG0594">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="242811at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF46">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO00165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="374" mass="42679" checksum="4A6074DFD9C0A033" modified="2014-11-26" version="1">MATPCKTQGLESCHSSFMDQSRYCSGGAAEDEWDDAISCSSSPQRNGAFDALSAQRRRRICRGRRHLIGIRDAILRPHEQLAYVAMDYCEGGDLWHFMRGLKTSVRCVSGKFGDVMSTRVFRRWAVELILALGFLHSHNIAHRDLKPQNLMLAKRTDITMPSSSSAIDRANGYESHHMEDAPAGELYTLKVGDFGLSRLEGIPYKKYVHEAVTLWYRSPDVLLGNTNYTYSADTWSLGCILIEMASGSVLFKGKDEADELRHIFTRGCRPTPLTFPRMREYHYCERYAEVLSRYEEADPDNVTMEELMQMQVERLSRHLRAFLRDRHSLELLGDAGVDLVARLLILDPERRLTIMEAMNHRFFTAAYAEVYGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RY31</accession>
    <name>A0A088RY31_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_320320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO00919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701719.1">
        <property type="nucleotide sequence ID" value="XM_010703417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RY31"/>
    <dbReference type="GeneID" id="22577773"/>
    <dbReference type="KEGG" id="lpan:LPMP_320320"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320008000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_320320"/>
    <dbReference type="eggNOG" id="ENOG502SM6D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272001at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="343" mass="37873" checksum="010647CE81575049" modified="2014-11-26" version="1">MRLSTRDANAQGRLSKSPCIPPSQVDVGVLCASREAWPPLLPSFSREAVEAMNRFVQGFICKRIEYRCGQLSAADYEEAFLPRWVRMAEHRTDLMEGFFAQHGSRLSEEAFHQLFGAFEKMQSALRDARQESGGVVEGCHDKRISFARPVAHRLIRRSRDRFSLRSVADADESVDLSHFSPSSCPISAADAWRDSLQPGSSSPVPGGPVLSVSSVSEIADADDVCTVVLPVEESADGDHFTGRASGVYYGDLFRSAGSSASSISDSSHAAATMTFPLSVKRDSLEGGAEFAEALLQVCRGPVRRAATWRRLWLRCFYHCILPAMVVLFVAAHYWDTMQLYLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RY37</accession>
    <name>A0A088RY37_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aspartyl aminopeptidase</fullName>
            <ecNumber evidence="4">3.4.11.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_292380</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate.</text>
            <dbReference type="EC" id="3.4.11.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the peptidase M18 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.21" evidence="4"/>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700842.1">
        <property type="nucleotide sequence ID" value="XM_010702540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RY37"/>
    <dbReference type="GeneID" id="22577001"/>
    <dbReference type="KEGG" id="lpan:LPMP_292380"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290026000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_292380"/>
    <dbReference type="eggNOG" id="KOG2596">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9880441at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05658">
        <property type="entry name" value="M18_DAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.250.10:FF:000001">
        <property type="entry name" value="Aspartyl aminopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="entry name" value="Aminopeptidase i, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002759">
        <property type="entry name" value="PRK02813.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570:SF3">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101821">
        <property type="entry name" value="Aminopeptidase/glucanase lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11 12" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 11" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIO00185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="453" mass="49377" checksum="FF0D8CC511B08FCC" modified="2014-11-26" version="1">MSTIMSDHVVKMAKEFVSFMNQAITPFHTVQTVAAMLRDAGYTQLDEEKHWEEIAPGGKYYLTRNGTSIVAFAVGGKFDPASGVKIVGAHTDSPNFLLKPRTRSTSSDYQRVAVQCYGGGLWHTWFDRDLTVAGRVIIARERLEQKIIKIDKPIMRIPNLAIHLTTAKDRETFSPNKESHLIPVISTQIAAKLAECDDNDGSNPNHCISLMKAIASVAGCNPGEIVDFDLSVIDTQPAVIGGIHDEFIFSPRLDNLISCYCAVKALVGADLLENDSMMRMICLFDHEECGSSSSQGAAGSLVPDVIEHIVSNKTLRATLVANSFLLSVDGAHGCHPNYADKHESAHRPALHGGPVIKYNANIRYATNGLTAAVVKVMAKKADVPIQEFVTRNDSPCGSTIGPILSSLSGIKTADIGNPMISMHSIREMCGTLDVYYMTKLIESFFVNYQNSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RY98</accession>
    <name>A0A088RY98_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Intraflagellar transport protein 140</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_320340</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO00921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701721.1">
        <property type="nucleotide sequence ID" value="XM_010703419.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22577775"/>
    <dbReference type="KEGG" id="lpan:LPMP_320340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320008200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_320340"/>
    <dbReference type="eggNOG" id="KOG3617">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10258787at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000031">
        <property type="entry name" value="Uncharacterized protein TCIL3000_10_12370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056154">
        <property type="entry name" value="Beta-prop_IFT140_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056155">
        <property type="entry name" value="Beta-prop_IFT140_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056168">
        <property type="entry name" value="TPR_IF140/IFT172/WDR19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056156">
        <property type="entry name" value="TPR_IF140_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15722">
        <property type="entry name" value="IFT140/172-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15722:SF7">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 140 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23383">
        <property type="entry name" value="Beta-prop_IFT140_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23385">
        <property type="entry name" value="Beta-prop_IFT140_2nd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24762">
        <property type="entry name" value="TPR_IF140-IFT172"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24760">
        <property type="entry name" value="TPR_IF140_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="IFT140 first beta-propeller" evidence="8">
        <location>
            <begin position="130"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="IFT140 second beta-propeller" evidence="9">
        <location>
            <begin position="459"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="IFT140 second beta-propeller" evidence="9">
        <location>
            <begin position="640"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="domain" description="IF140/IFT172/WDR19 TPR" evidence="11">
        <location>
            <begin position="879"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="domain" description="IF140/IFT172/WDR19 TPR" evidence="11">
        <location>
            <begin position="1081"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="domain" description="IF140/IFT172/WDR19 TPR" evidence="11">
        <location>
            <begin position="1170"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="domain" description="IF140 C-terminal TPR" evidence="10">
        <location>
            <begin position="1439"/>
            <end position="1582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1623"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1627"/>
            <end position="1649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIO00921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1649" mass="180929" checksum="EF9B1C7010122C36" modified="2014-11-26" version="1">MSLFVANTLEHEGQVKKSLIAAHKCKPLLATVWVNPPSVLITNNEGDTLAPVTEPVGSTGRTQQPTALAWHPNEALLVIGWSNGTMSLWAMPLASSLALGEDDTSAATSSAVQLIAARAATQSDVEGAVHEHGAGAVLAVEWSTQGLYLVSASQQRHVVMWALEQTDTETGVNFKLKSLWSVQASESVVRIIHVPGHAAYPSMTVNAHNGASAAATAEGDDDDMSFLLADGSTSVAAINEEQQLFPCVTQQEAIVSVLYDPESRILITLSTSYMIEVYRISEDIKGTSTLRRKLFTTPTTAAATGEQIAMSMVWASPGVVAFGGGDDRLRVFGISSESMDVLSLPQPDLHVSCLATYTTKGIMTVGTVEGVLVVFQRRAACLPPSGHAPALREPAAVSSLFAAAASVASQWEALAIHQVGKFVDRVVFTALGDMALCRGGSELQVLHETIRKRSWDGVAAATQISADMVVIESVTGCQCLLRSKGSVRGLSIAFPNIALWNGSQIDLYAINEATSEFTLVNFVPTMSPAFAMHRDGLIYVKGNRVVFETMQLAPIAQMTFTASEGVPVIIDIMNDYLVAVSSKKYLRLARVSSRDLQQIGPARPLTFWSASQPTASDSASGASAAAPSVAKDAKALEISVAAARVNAQGRRVALMTSLGPLALPDTRVWVYDSDTDKMSSFDFSTRNEMPNSVYWNTPEPNTSTVGEFEYILLACETHQVHKEEKTAPEEVMTPKASVDGINADKSHDRPAGQENLPEALPNMENYAEKKAKLEEARRGSVGATNYVAQRAHNIVTLFATHHGLVVQNVASMRRYQICLVGLTIPDFLLASVKINGNPSAAEDYVIEQKRLRDFEGLKSDKDVAVREALMKFSYYSTIGNMDEAYRCVKNIKNPAAWQGLARLCVTSGRLDVAAVCLSTMEDCVAARALREAREDYPDDQGVQLAALALGLGMTEEAEELLRKSKRYDLMTDVYMAWGKFEHAQRHTERFDRVRIRPVAYKYAQFMESLQNMDAAIMWYYNAKCAGTDVPRIFFQTNRMHELRQLMVTQSQPLSPSASTNGSTEQSLHDERQSVFAAIFPQNRDLLLWWAQHSERRRNVQEALRFYHAGEDVYNIVRILCLLTPPKLDSAVQLVSKEIDKARTRFQQQQAFAAAPARLGDNEQGEPDPVGAAYFVGQLYERQGDGTRALQYYQAAGAYRSGVRVAWQAGQYGVVVNLAMKSSDERLMLEMAMALERQQAYDKAVQLYRRIGAVQCALDACVRGGLYETLHEVSTDFASGSTDPAVFLGMADHFQSEGDYQKAVEMLLFAKHYDEALKLCETRSVTLTEEMAESMTSDVGKLSMEERQALLRKVAHIAKDQGSWSLACKRYTQAGDRVKAMKMLMRGGETEKVIFFANHSRNTEIYTMAANFLQSQGWSTDANIYKSIILFYTKAKAWMSLLVFYESCAQLQIDENRNYPEALRALEDCISMVEGGPAGKASIGNEKVEQLKRRAEVLKTFVKAQKTVDSMVAADRGSVAEKAKAESVIASCSDIIKRSRPASQDHQLIHDALRIGDVFALMVRFYFDKLGEPNNALKVMESMPKHGTDPQLFIEMDYMERVCQANGKSLANVLPGMMAGGTHGAGWEGDRNMGTDTRRSSVIDEVDRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYG7</accession>
    <name>A0A088RYG7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HD/PDEase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_322680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701953.1">
        <property type="nucleotide sequence ID" value="XM_010703651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYG7"/>
    <dbReference type="GeneID" id="22578009"/>
    <dbReference type="KEGG" id="lpan:LPMP_322680"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320033000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_322680"/>
    <dbReference type="eggNOG" id="KOG2681">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9991235at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008832">
        <property type="term" value="F:dGTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3210.10:FF:000039">
        <property type="entry name" value="Protein CBG02420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050135">
        <property type="entry name" value="dGTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373:SF4">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="2">
        <location>
            <begin position="71"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="562"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="662"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="673" mass="75361" checksum="27E48A85A704A1E4" modified="2014-11-26" version="1">MPPPLRFKAESVRREEACNVVEPKRSMSVRDTLYGQLEFPPVIRILADSPVVQRLRDLRQLGNSFYVYPGATHSRFEHSLGVCYLGMELYRSIVDGHREEHRDFGVPEIANQTREAAQKDMQCIGIAGLCHDLGHGPLSHLFESFVRSCARPEEVQLRKWSHEQASIMLLRKMWSENETELGELGFTEVDLRYVELLINGLAPGKAWPDNVGRQKWARFTTEIIANKRSGLDVDKIDYIQRDSVACLGTPTFVSMRRLFQGARVVVGDDDETSIGYPDKLDGVIEEIFLARSHLHRIVYQHRVTKVIDLMTLDALRAAGDVFEVSNGKDCVMPLRSCVLHPDFYVHASDWIVLAILHGSNRKIPETLGSSASAEYRRERLGAARRILQRIQSRHLYTTIGSYRHSEQTLINAGRLNSVEGSSQEVKREVMIQELLSDIEATNLDLSMKLHEWSRQHNGMAAIEILQAEITQTAGDMDKRQDPVSATYFFNPRQSTHCRVEPHFSCNVTTTLFVKMGPVSSLVVVCRMTLTPQEKESLRISFTSVADRLGKTDASSFSCTPMSQRGRAAESSQQAASGAQDESVATPNHSMRETGGLTFSMGSDYPAAKRLKLDLDTRLYERAGFDVDQSSEDVLPNGATMRSLELATSARGGQMGTKSQDDGNGEETDILSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZ29</accession>
    <name>A0A088RZ29_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pumilio protein 6, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PUF6</name>
        <name evidence="6" type="ORF">LPMP_331210</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702213.1">
        <property type="nucleotide sequence ID" value="XM_010703911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZ29"/>
    <dbReference type="GeneID" id="22578274"/>
    <dbReference type="KEGG" id="lpan:LPMP_331210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330017200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_331210"/>
    <dbReference type="eggNOG" id="KOG1488">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF183">
        <property type="entry name" value="RNA BINDING PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="5">
        <location>
            <begin position="377"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="401"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="437"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="473"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="579"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="616"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="723"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="314"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="795"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="691"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="341"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="807"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO01413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="818" mass="89601" checksum="A30A3C36252E147D" modified="2014-11-26" version="1">MYSEQNWNNHHAAAGAQRFTRGGAIGNTNPNGHGGGCGYEVVSAAAAGGYSAVPAAHQKSPQPTGFYPPTSSRFTPMDFELFINSNRDPTDEMRRSHEYYYWYHSKQPHDLRAPAPLPSLDVQETLTNMETPWEEVSTMPSATVARAGAAGGLGRKMGGKNLALDAKDLCETQEVQAINPYGHSLITESNMMSPSTQFFAAYAPTPLAMATPSTLRAYAHGHLPMPSSNNCGTYESEVAGGATYGRGGPTAKSIASQQYYTQEPMSTFGLYSTGVEAGSNYYDATQGSSSNGLGADHSNAYQLMEGMGELDPAMVYTQPGTDSGFQSRGPSRGGNRRYNNSGGGGRRVGRGNYRGGRSAGGMGNIEGGGGPNSHRFVGSEKLHMFRHDVAEQKTSQWRLEDLNGYAVEFAKDQEGSRFIQSAVDSASPESLDILFHEIFEAPLELVTDIFGNYVLQKLLDKGNTPQLTFAAERMCGHVVELTMQTYGCRVIQKCIEVMPPAGLDIILAELKDNVAKCIQDQNGNHVIQKCVEVIPQQCGFIISAFSGRVMELATHAYGCRVIQCIMQHCPEQEDTIFNELLKAVDVLAKDQYGNYVIQHVLQNVKDENKIESVYAALKPKFFYLSKQKFASNVMEKLYARSSPENRMAIVEMMCADFPAKADHVEIVAFKRSTTKTAAIVSAEEGTWPPTRNNADGTVKEVKEKNREAKDAAMGIIEEAVSVGLGQPSMLCLMMSDQYANYVVQRVLDASEVDQFVKLVDNIEKYILPIRTYTYGRPIVQRLSRRKLVLAPGDEAGEAGNNSVNNHNHNEGRINYHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZ66</accession>
    <name>A0A088RZ66_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_331560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702248.1">
        <property type="nucleotide sequence ID" value="XM_010703946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZ66"/>
    <dbReference type="GeneID" id="22578309"/>
    <dbReference type="KEGG" id="lpan:LPMP_331560"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330022100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_331560"/>
    <dbReference type="eggNOG" id="KOG0144">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000686">
        <property type="entry name" value="RNA-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="19"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO01448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="129" mass="14502" checksum="B2ACA5BDCAE18BF0" modified="2014-11-26" version="1">MTVNNGSNNNGERLGSGTARLFVGQLNFDATEHDLRQIFSFYGHVIHTNVLRDADGKSTGSGFVTFRVTDEADFAIMSMHDRYNMGREKPLQVSYCRRSERISAFGYEHAMKLREKNTTNPPPPQPTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZ82</accession>
    <name>A0A088RZ82_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_323470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702031.1">
        <property type="nucleotide sequence ID" value="XM_010703729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZ82"/>
    <dbReference type="GeneID" id="22578088"/>
    <dbReference type="KEGG" id="lpan:LPMP_323470"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320041300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_323470"/>
    <dbReference type="eggNOG" id="ENOG502RFXC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="260254at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="26806" checksum="102734FC79EAE12E" modified="2014-11-26" version="1">MSSFTPSTPLSYQGGGGGGIRDIGTVTSGMAIMNFDQKTKPYTRSDLVQFLMNYQANLNEVELRLVEKGMVGTFVGIPVFFGAGYFLSGRLGWHRVVRAMAPLSEEGRPSWLVTHLPKIGRIAFGLSAATIPYIAVQQWFVSRVLELDERESNLSFHVRRLMLSQRSSMMFKRTATREVTREEQQRLLREAEAHVNENRSGQRVSQGLGTGPVDVNLQLGQQVLTPLAQTGYKPMPTQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZ83</accession>
    <name>A0A088RZ83_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_310080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701400.1">
        <property type="nucleotide sequence ID" value="XM_010703098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZ83"/>
    <dbReference type="GeneID" id="22577434"/>
    <dbReference type="KEGG" id="lpan:LPMP_310080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310005700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_310080"/>
    <dbReference type="eggNOG" id="ENOG502SAYB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="172"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO00600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="230" mass="25582" checksum="B7A7A57FE9F22590" modified="2014-11-26" version="1">MMQRTHYDAQGPMPQYNRPSYNDTGYNMSRPMDGMPHQGYNHPPVNYYPPPQGYPMGNPMYNVPQGYPPAMPGYRGGRDRGYWYYPSAGRGGYNNMRGGFRGGRGGFPLRRKKPFVGGTLETQREWERQTACCFNLQGSCKFGDGCRFLHTAVEGRPCQFGVKCRVHGTAKDAEVEAPAKEEPPKDEKAAEAKPEKAEESTAAKKSEKPAEKAPEKRAAAESTNATEGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S063</accession>
    <name>A0A088S063_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_333010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702391.1">
        <property type="nucleotide sequence ID" value="XM_010704089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S063"/>
    <dbReference type="GeneID" id="22578454"/>
    <dbReference type="KEGG" id="lpan:LPMP_333010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330037900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_333010"/>
    <dbReference type="eggNOG" id="ENOG502SFY1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272689at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="408" mass="44447" checksum="33703FA5033DE64D" modified="2014-11-26" version="1">MANASASAPPLSTSPPRHWGSDLLLRKVPLYAQARQYANVDPDDTWSEGNTLGYGPSSYPLLAAVRSCYEMVNRDEVAADTSSKLRVTTALVDRSPFCGIDRAGYAHVPAQRKWASTNPLVAESASRNSEQPTALVRRAAAAAVLDDALGPATLAQVLEPWFGVIEDCLCASAQQQQVEERVRPEGRKAKEKAAKRSDNGAAGAPEDGDTADNDTVRVTDADVLRMLRRKRIYNREDETHGAVYTRLESVILHYSAATPEEKEMLRISRVVSSDPSAAVLIPGQGNTATAPSQETWGSRMLSLVTSTVAAEAGGGAARRSDEEAEQQQKVLAYLKRVRWIATQWSSTTNQMALKDAGTSALSWGQMTEAQRVKVEMLHTQRQRRRFRRPRRGGDGAKGNDNDADAVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0A5</accession>
    <name>A0A088S0A5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase/reductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_342020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702628.1">
        <property type="nucleotide sequence ID" value="XM_010704326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0A5"/>
    <dbReference type="GeneID" id="22578707"/>
    <dbReference type="KEGG" id="lpan:LPMP_342020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340026400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_342020"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF152">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO01828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="485" mass="53480" checksum="F98A1016B5771102" modified="2014-11-26" version="1">MFHLFASEVAAFASMVLFVLMYGVFYFFDIGWAREPTAVDVFVLICSCIFACRTAAKGKVCQWPSGVDFTNRVALVVGATSGVGYSTAMQLAEHGWTVVLAARNIDRLLFSKKAIDRYLQRCNAKGSVKVLGTVDLRSDASIRAYVKDLAAVKAQLPVGLLIMAAGAMHRHLHFVGELEELRIGKASVAASSTAWRSIECMIAANAVGPYLFTQLMLPLLDETAERTSVTSRIVNVASSCHTFLGPGRQARYSPVEMIHGLDERAAEVLPGDDSGEAKKGKTARGPYYIRDYSWASFVGYYGLSKLCVMWNTRLLARQVATMRFIEKTAAKTPALRKPTMNPSPTDPAQNITATPETARQDQLKIFVACTHPGIITTYLYRDIFAPWMLDYLLYYPSLVFGKTWFESAQSTLKAAVEDTGMVQGGYYLCSGEYGPESGVNCVSAHTQSLTNMEEYRKWLMARVVPALKPESSDTGTRNQDEAFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0D5</accession>
    <name>A0A088S0D5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_342420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702668.1">
        <property type="nucleotide sequence ID" value="XM_010704366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0D5"/>
    <dbReference type="GeneID" id="22578747"/>
    <dbReference type="KEGG" id="lpan:LPMP_342420"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340030200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_342420"/>
    <dbReference type="eggNOG" id="ENOG502S6ZK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271720at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="218" mass="24320" checksum="25B61822E4844E6F" modified="2014-11-26" version="1">MSSDDIDALRAELLRQKIIFEAELRRQREMFEERLSIISNELADREADCLNLQSVITILGRKVDAIAEQREHITVAHRPLTPARQPSIRESPFRRNPSTLVPRPGSNGKPQERPRANSTVTPSGIRRPSPSFNDPPTSLHRSGMSITRVASLSTLSRTNSPLVRGHPVRPLLRTNTSATLTSDVNSSCGKRVPRRRTVSRRRTNSVSHVAGITRTNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0J0</accession>
    <name>A0A088S0J0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aspartate aminotransferase, putative</fullName>
            <ecNumber evidence="8">2.6.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_340750</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="8"/>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702501.1">
        <property type="nucleotide sequence ID" value="XM_010704199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0J0"/>
    <dbReference type="GeneID" id="22578579"/>
    <dbReference type="KEGG" id="lpan:LPMP_340750"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340013000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_340750"/>
    <dbReference type="eggNOG" id="KOG1412">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000064">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF55">
        <property type="entry name" value="GLUTAMATE OXALOACETATE TRANSAMINASE 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="38"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO01701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="409" mass="45723" checksum="D2B150234672BC57" modified="2014-11-26" version="1">MSAQTTMTTAEHWQMIEGQVPDAIFGLAKRATAAKGPKANLVIGAYRDDNGIPYPLRVVRKAERLLIDMNPDYEYLPISGYQPFIDEAVKMVYGDAVELENLVAVQSLSGTGALSLGAKLLTYVYDAEKTPIYLSNPTWPNHNSIVKGAGWKNIHTYTYYDPKTVSLDFEGMKKDIQAAPNGSVFILHQCAHNPTGVDPSQEQWDEIAELMLAKHHQVFFDSAYQGYASGNLDEDAYAVRLFARRGIEVLLAQSFSKNMGLYSERTGTLSLLLKNKTKCADVKSVLESLIRSEYTCPPAHGARLVHLILSNNELRKEWEVELAAMAERIRTMRRIVYDELLRLQTPGSWEHVINQIGMFSFLGLSKERCQYCQDHNVFITLTGRANMAALTHETALLLAQTINDAVRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0Z2</accession>
    <name>A0A088S0Z2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal subunit protein L31, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_343130</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702739.1">
        <property type="nucleotide sequence ID" value="XM_010704437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0Z2"/>
    <dbReference type="GeneID" id="22578818"/>
    <dbReference type="KEGG" id="lpan:LPMP_343130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340037700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_343130"/>
    <dbReference type="eggNOG" id="KOG0893">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276936at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.440.10:FF:000003">
        <property type="entry name" value="60S ribosomal subunit protein L31, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000054">
        <property type="entry name" value="Ribosomal_eL31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023621">
        <property type="entry name" value="Ribosomal_eL31_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01198">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01380">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54575">
        <property type="entry name" value="Ribosomal protein L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO01939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="188" mass="21372" checksum="38F860B5939EF219" modified="2014-11-26" version="1">MTRAGMKGKVLGKEKKTAIIDARKKAVESRRSRDDKRWKRVIARMDEEKRKRFHGVGNTAKNSRARGTTRASLRKRTGRKPDAVSMEATIHLSKLLKKKTFAKRAPLAIKRIKAFVGRLMKTKDNRIDASLNTYIWHKGVKGVPGRVRVLIQRKSETAEGNKHKHFFTVISNVPVASFKGLTTKTVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S197</accession>
    <name>A0A088S197_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">T-complex protein 1 subunit eta</fullName>
            <shortName evidence="11">TCP-1-eta</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">CCT-eta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_343730</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterooligomeric complex that forms two stacked rings.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702796.1">
        <property type="nucleotide sequence ID" value="XM_010704494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S197"/>
    <dbReference type="GeneID" id="22578878"/>
    <dbReference type="KEGG" id="lpan:LPMP_343730"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340044800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_343730"/>
    <dbReference type="eggNOG" id="KOG0361">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1935484at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03340">
        <property type="entry name" value="TCP1_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000022">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000006">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012720">
        <property type="entry name" value="Chap_CCT_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02345">
        <property type="entry name" value="chap_CCT_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0346">Stress response</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="525"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIO01996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="571" mass="61724" checksum="86BF87267FABB3A7" modified="2014-11-26" version="1">MIQPQLVLLREGTDTSQGKPQLISNINACISIVDTVKSTLGPCGMDKLIHNGRDVQISNDGATIMNLLEIVHPAAKSLVDIARAQDNEVGDGTTSVVVLAGELLKESKQCVEDGIAPQVIVKAYRNSLSIAMKALDELCVPFKAEGNSSEENLIRCAETALNSKLINTERRFFAEMAVKAVMALDEDMNLELIGIKKVAGGSMRDSVLVDGVAFKKTFSYAGFEQQRKKFDNPKVLLLNVELELKAEKDNAEVRLKDPKQYQSIVDAEWKIIFDKLDKCVATGANVVLSRLPIGDLATQYFADRDIFCAGRVANDDMTRVCMATGGVVQSTLNNVPAEVLGRCGMFEERQVGTERFNFFTGCKTSKTSTVILRGGAQQFIEEADRSLHDAICIVKRAIKTGSVVGGGGAIEMELSKKLREYSRTIKGKEQMVVAGYARALEIIPRQLAENAGHDSTGTVNKLRQKHYVTSERDSQWYGVDIFNGGVCDTFANFVWEPTLVKRNALQSATEAACLILSIDETVTNPESDAGKKQAAGSGGGRGGNMAMSKAGMGGMFAGAPGVTRMKGGRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2C9</accession>
    <name>A0A088S2C9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Lanosterol synthase, putative</fullName>
            <ecNumber evidence="11">5.4.99.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_060620</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the terpene cyclase/mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.8" evidence="11"/>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703943.1">
        <property type="nucleotide sequence ID" value="XM_010705641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2C9"/>
    <dbReference type="GeneID" id="22572268"/>
    <dbReference type="KEGG" id="lpan:LPMP_060620"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060011900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_060620"/>
    <dbReference type="eggNOG" id="KOG0497">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21502at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016871">
        <property type="term" value="F:cycloartenol synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000250">
        <property type="term" value="F:lanosterol synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016104">
        <property type="term" value="P:triterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02892">
        <property type="entry name" value="SQCY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000003">
        <property type="entry name" value="Terpene cyclase/mutase family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032696">
        <property type="entry name" value="SQ_cyclase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032697">
        <property type="entry name" value="SQ_cyclase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018333">
        <property type="entry name" value="Squalene_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01787">
        <property type="entry name" value="squalene_cyclas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764:SF20">
        <property type="entry name" value="LANOSTEROL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764">
        <property type="entry name" value="TERPENE CYCLASE/MUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13243">
        <property type="entry name" value="SQHop_cyclase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13249">
        <property type="entry name" value="SQHop_cyclase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01016">
        <property type="entry name" value="Prenyltransferase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene cyclase N-terminal" evidence="10">
        <location>
            <begin position="389"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene cyclase C-terminal" evidence="9">
        <location>
            <begin position="651"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN95621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1004" mass="113493" checksum="5F69EF9B9B276B36" modified="2014-11-26" version="1">MDANNGHPTSARAAVSGSLTKPHDAHVNGLTSSEFERQSSSSAGTVADIAGFVSATLRDLYAHAVAITQPCAAEHARFVEYQRTLPVRTVVPEPPNTLRDYTRHQVWRIGRSCFLFFFFLFTWPVWLTLHLLLKLLDVHQRRVRLRYHRSWAHASVPHIRPNVHTPSSEFPLSAWHLRCEDGRQRWYFGEPLREGEAYNELALAQLSGLHTVNDYHELLLQRAKSDLGDDDQGVRSRSSSSCGTGVVSNRVPRLLDVLAEKCARRDFLEKYQLGLLPPSSPKPRTTSEAAMDDGIRFLLKLQDPFSGHWPNGYSGCLFLCAGFVITKYIVAGGETRRMFPPFSDHHHVKLASSSSDTKQRSSCGDYPERVLGVPAAENAGEERCQCGEAMRQELIRYIRNHQNLDGGWGQHTEGHSTMMGTVLNYVSLRLLGVPASDPQATCGRSWILAHGGATTTPMWGRVWLSILGVYSWDGVNPISPEMLLMPDWVPFSLGKMWCHSRVIAIPFSYFYGLRWSAPAFPTTLALRKELYTEPYATIPWRSFRGVVCELDVYSPTSPLFRVAMGLLDLYERHPIPFLRRYALEVSWRHMAYDDENTHFICLGPVNKWLNMLATWLREGEHSARFQEHFDRVSDYFYMGETGLSMSGYNGSQLWDTSFAVQAICACRREMMFPAEVELAHHYIDVAQVQEDPMAAPYFYRHRTKGAWNFSTRSQGWQVSDCTAEGLRALLLLPQYAFPMRRIFDGVDEVLSLRNSGLGGDGGWASYEPSRAPAYCELLDCSELFKDVMIDYSYVECSSSCIHTLSLFRERYPHYRRRDVDRAISEGIAYVLGQQQPDGGFYGSWAVCYTYAAWLVADALQASKELPEMASHPHCRRLIDFLLSHQAADGGWSEDISASARQTWVDSPDGSQVVNTAWAVMAIISAAGKAASTEPTRQRCIRRAVDRGVQLIMSRQLASGDWRQERISGVFNGNNPIHYPGYKNSMPVWALGKYNMWKREYAAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2M2</accession>
    <name>A0A088S2M2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_353680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703304.1">
        <property type="nucleotide sequence ID" value="XM_010705002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2M2"/>
    <dbReference type="GeneID" id="22579396"/>
    <dbReference type="KEGG" id="lpan:LPMP_353680"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350044900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_353680"/>
    <dbReference type="eggNOG" id="ENOG502S6XG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272540at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="474" mass="51776" checksum="C15C27438A4EC3E7" modified="2014-11-26" version="1">MSVENTFETFCAMSALQQRRDGLLVPPESSRSFSYYQWLEVAKAKYAVSQPLASSSPSQRRPPAKRAKKESSASDSGTTLADGLAEQLVASLERQKGPAKAPASLRYAAQEAFPMPKASADMPAFLALAEAAIRLTLWTPQDTRLAQLASSLRPNLRTLEERGVIRFYYNCFPSLQLLMDLLSWRIIAHRWERLTPELQHVAVDGVLTLCDCLDSVATEALRAAVHELRMSTVSSSSADPIELTALNTLVAHVSATVPFQFEACRDLVPLYPEPVGLLRVPGTSVASIKSMLGKGQLSQPVEEEQANDDGETRVGELLGEICTPTLLGHASLEGESSSRRVHAAAEAAPPSRPILKAVAHTTGGMRPPAGVAKTCHKIPTRTASGHSACMSQYHMRYADPAKHASSECPYCATCHLMEIIFRGNTGNCLWSHWPTPRKIQLHLKQFPQVMKLAQERFAAMRRGVKLASTDEVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3L4</accession>
    <name>A0A088S3L4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Elks delta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_357170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703644.1">
        <property type="nucleotide sequence ID" value="XM_010705342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3L4"/>
    <dbReference type="GeneID" id="22579745"/>
    <dbReference type="KEGG" id="lpan:LPMP_357170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350081400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_357170"/>
    <dbReference type="eggNOG" id="ENOG502S66A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272037at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="41728" checksum="B3E40EBBD501B192" modified="2014-11-26" version="1">MSTGPQESIDELRSELQQLENLLMKREEALLHKRQQSQRLNSDLADAHLETASQEASKATASDAYRAASRAKQVLENNQAQSSQSLRPNREEYVSQLIEADGAKKSVEAEAGEISARIKGLKEKKVDVQKRLTVARLVSMLDDLQNLLKQKVYGPSGGEETRAQELLKTVQELSRERERTIHFLSKKEREMAALINLKQQRVEELRSEFTRNVSTYADSNIKELFGVAQRIQVERSQLLSEIERLEEANQKIVDVLTDTKYTTESAIKDRDTALSGVTMMGVSLNPEKESLQLRERINKANSERRMYMLKTEELQGNIDEATLAYSACMSKLRKEFLLYQDESIRFEKENKKLKDLCDALARSLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S448</accession>
    <name>A0A088S448_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein kinase, putative</fullName>
            <ecNumber evidence="6">2.7.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_110250</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.-" evidence="6"/>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696874.1">
        <property type="nucleotide sequence ID" value="XM_010698572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S448"/>
    <dbReference type="GeneID" id="22572890"/>
    <dbReference type="KEGG" id="lpan:LPMP_110250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190005400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_110250"/>
    <dbReference type="eggNOG" id="KOG0585">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14008">
        <property type="entry name" value="STKc_LKB1_CaMKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="698"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="225"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="339"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="438"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="490"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="603"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="740"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="782"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="948"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1074"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="298"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="454"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="506"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="618"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1089"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1121"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1154"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1165"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="731"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN96221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1194" mass="127139" checksum="6D7FF2491A074AAE" modified="2014-11-26" version="1">MSSPSVAALCSLAFSLQLFPHPQPQPIGVRAADVDFVVAAAAQLERNQREGEQKLRRCGPLSPPASPLFLLRGPRPEHSSQLSMPLCVSKPRVCCFRGKRTERALSLTRATAGTDQLLPPGAAAAQQWLPRAGVAGRPRQSWCSRRSHSPARTRQPTPIVFYGRTLEKLHSTMSISEAESGNSGSGALRVQAGASDESGKFDKAMKTYQRSMAIRRHLANMSASTTCFPDNRGDGSSGSGGALSEVNTAAQTSSSSLRGPQLRSSVLITRVAPAPSTASVASSQRPRVLPEIAASVVKASKTTATTSSPTVTLGAGSSTETCSSMTASIPHAHVLPPVLSTVTRPSNPPFAQEKTAPSSSSPLCVTAQLRSSAKHGNSDRDNANDSSNGEEDAVVQKNTLDSSAPIDPPRLLPLASGWGLIAYDPKVVAERQRTAAWHNSRSFDGGTHDHADQLSASTTDSRQPSQTPSFHQMMGGTYDVPTLGTIFRGPCNGVDRRQQGHQSLLAPPSSARAPIPAATPARQHPKKSITAAAVEPMLSPSASTGLQLSPSLISKSSVSSPAAAVIQQAPPVPASSSAAARAQAIQIGDNDLSYLASRFPAQVAAEEDQRTSRTAAKARPEANERSTGKGRGGVHAGEPLAMVRMPASDLSLKPSEANVTPTVTSPLGKNLARTTTAQFYSTASLTKTFDGAEYLNDYILLSDIGSGATGRVVLAFSLSMNKTVAIKIILKPKENNRLQRRASASALGSGQHSEKGGGSGRRTVGALATTAPKDMQNCMLSFSSTERQSERTKTSPTPLTTVAGKTRNVQREIEVMKDLNHPNIVRLYEVINDPKANSLFLILQYVDRGAVAQLDSTGHIRASLHPWTLLPIATQVSDSLVYLHEQHIVHRDIKPENILVSRDGHAFLADFGVAELMNGETGQPTAATLAYQGTPLFMAPEIYAGVDDEEEDEDDQQTPGGCTQRRSSDDSGQSSSMKASLSREEERGLRVIDPFALDVWSLGVTFYTLLIGHVPFTSMLQIRQTVQQGVNIPTSLPGEWRTVLRRTMEPRQESRISSAELRHMLHAMLAEQEAAEVTAGGRGRKESRSTTLSRPRNASHQSNTASPSTRRVSCAADTGEESVNLGSSSSGSGNESIISGSGHRLVSSSHFTSDDDGDNSDDTTDTSRHDHRNLDLSINSSVLDVLRPTNPKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S4Q0</accession>
    <name>A0A088S4Q0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Sugar efflux transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_354990</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SWEET sugar transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703430.1">
        <property type="nucleotide sequence ID" value="XM_010705128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S4Q0"/>
    <dbReference type="GeneID" id="22579527"/>
    <dbReference type="KEGG" id="lpan:LPMP_354990"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280008900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_354990"/>
    <dbReference type="eggNOG" id="KOG1623">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="409725at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051119">
        <property type="term" value="F:sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047664">
        <property type="entry name" value="SWEET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004316">
        <property type="entry name" value="SWEET_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10791">
        <property type="entry name" value="RAG1-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10791:SF30">
        <property type="entry name" value="SUGAR TRANSPORTER SWEET1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03083">
        <property type="entry name" value="MtN3_slv"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIO02630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="25871" checksum="112B18BABB15280E" modified="2014-11-26" version="1">MGVFLPIIAVFATAASMCMVLSPVITVGNMRAANSVGVGTITFFCAQLLNCSVWAMYGVQTISLPVIICNTVGSATAVYCILTFLAVARMQEKAGHVLSSTSYRSSLNSAIFTAFLIILFMLLLLYLINCANWSSTAQLNGILGGCCSVFMLSSPLGMAKVIIREKNAEPLQPETVSFATLNSVLWVLYGLLKFDMYITIPNVLCTLACIFQVFLLVRYGRRTAQRLHIAEALSPVPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S5M5</accession>
    <name>A0A088S5M5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA repair protein Rad9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_150990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697474.1">
        <property type="nucleotide sequence ID" value="XM_010699172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S5M5"/>
    <dbReference type="GeneID" id="22573519"/>
    <dbReference type="KEGG" id="lpan:LPMP_150990"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150015100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_150990"/>
    <dbReference type="eggNOG" id="ENOG502S626">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="60092at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071479">
        <property type="term" value="P:cellular response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007268">
        <property type="entry name" value="Rad9/Ddc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839210" description="DNA repair protein Rad9" evidence="2">
        <location>
            <begin position="29"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="495"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="688" mass="71099" checksum="EB6D9A0EC65C815C" modified="2014-11-26" version="1">MSLQFTVSGPNIRVLLSVLTCVSRLGEAVYVVGLSDGIEISAVSPGRNGYMAVRVHARCFDRFLLEPPSHRSTVDHGSGLVATDAAAGGNADVSSVDTPNPSLCLLTKTLVATVLRQHNNVQSLDFQYRTAASSGSAAAAMAESDADKDSSDADHDLWKGRADADVVRWHCTYARNLTKTFLLRLAEGEPTSVYADLSRYRFEVCGDARTYGSLLASLPSSANQCALTLPESGGLELRSVRQAGSSSSSSAAAASSRESGSAAAPSGSTRAADGSSTVVTAFESTFTLFRFFEPTASPPVASTGAAATELEVGPSEVSPTPFSITPQQQQQQRPQRNFAVSVPDHPPWATATVNFVSLPSKTFDVKPFKNAAWLAEQLGVQLHLLTGEEGVPLIIASITPEEVRQWRESLSCTGSAAGRPLLVTSNSPPTSAPTFISFILYVAALDSTPSAGRASGSGGAPVGVADTSIVTAISSAASSPRTSMHHRTSKGGGAAQAAVAATPAPGYGEEENGEHDGMLVSSGTLSHVEASLASTNTAARGGGMVGRLSRESNSTVNSAYVTPRPTASPSELVMVMTGGDTPSTRSADTGGGDAAHKALGLPRGVTASSLPGCSTVTMPGATAHSAAQPISSSHTTTFTALNTMYPLDFDAFVRTYTSMNEADGDAEEEDAQDAELREFLASCVASMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S5R6</accession>
    <name>A0A088S5R6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4211 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_151540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697529.1">
        <property type="nucleotide sequence ID" value="XM_010699227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S5R6"/>
    <dbReference type="GeneID" id="22573574"/>
    <dbReference type="KEGG" id="lpan:LPMP_151540"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150021200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_151540"/>
    <dbReference type="eggNOG" id="ENOG502QU1S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="263049at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="388"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="543" mass="61895" checksum="548F5966AA9CD5A6" modified="2014-11-26" version="1">MPPKRKLSRHGKALGGELNLDAVSKERIDAVTAEPLDPVKFIEVLSPDQTLRLFYNTTTLIRIAVDNGGFMQPPHFREPMSNALQKQIEDIEGKKFHFESRNTVIQRDEGEEGSGIAVLHRHVYFDQIMDEFYLLNPAEVFVCPMCYEHYLTTRFLPARMEEGRSVKHLRNNQPVVDPLDVLLHMQGEGPSTGAADNEAAIVPDSAWDNVLAHIVFRRAAQWKAHLETQHWVTGVSATDYRLRDVLCTYYNNYNQWNEEKYEEEVKLYGSARKKAALTLQRYWHLNASYNRLRYNRVVAATELAEDHAEAVTVSAFPNETVAHHFNPEDEDEDDFIDDDTDTEDYVPPYLPEDEELSDMEDDADKSEGKTPQRRRKRNRERSVESMFASSPSASSSTTASSSDSDYDAEVEKQRALFKRGLLAERDCYFSRLSAEDRHFFEKSQRSNVAPSQLYDPHMHPNSTHLSTLDDDIDWENIGEVLPIKSPIKLKKEISPSLPPAGADVGSVKSKLLLDDDEPLPHLVPQQQLAPSARSSHLLLDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S5V5</accession>
    <name>A0A088S5V5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amastin-like surface protein-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_160470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN96921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697574.1">
        <property type="nucleotide sequence ID" value="XM_010699272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S5V5"/>
    <dbReference type="GeneID" id="22573624"/>
    <dbReference type="KEGG" id="lpan:LPMP_160470"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160008700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_160470"/>
    <dbReference type="eggNOG" id="ENOG502SN4Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272501at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40741:SF1">
        <property type="entry name" value="AMASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40741">
        <property type="entry name" value="AMASTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839211" description="Amastin-like surface protein-like protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="19855" checksum="9162F8941515E76D" modified="2014-11-26" version="1">MLCTRVLVLIFVLLLAACGVCAALFPLMRTKGPMIDGHPSERVVFLWYEETKFTVGPAHYYTRTYHRNSTCDGFKTAALASAALDVAGCGLAGIIGLLAAAHLCSRMKFSICCSIMVLCFVAFACFVASVATVIFTFFTDTCVNDNATRVVALRDQGFVLVEGFIFLCIAAGGFLIAVFVEIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S5X3</accession>
    <name>A0A088S5X3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_160670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN96941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697594.1">
        <property type="nucleotide sequence ID" value="XM_010699292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S5X3"/>
    <dbReference type="GeneID" id="22573645"/>
    <dbReference type="KEGG" id="lpan:LPMP_160670"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160010700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_160670"/>
    <dbReference type="eggNOG" id="ENOG502SG6H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="248656at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="762"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="612"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="803"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="477"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="520"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="612"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="805"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="844"/>
            <end position="858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="858" mass="89312" checksum="EDB6510D7482A73A" modified="2014-11-26" version="1">MEGLRRQVELLCTALESLDVRHDSRCRDHPPSLPEEVVSALQVALARATALADWATAVQREQPLPQRTSDVSDAAGLKFGASAQQQTLLSVAALFKVSVADIRQWNPQLPPTLREGDVLPPDTYLKVRPAPSPVSPPQRSSTSVSRTRLVPGATASLGVTVSGTTSARPTSAKSQVTDAGCGDSVAAPWHHSAFSSSPSGCSKRDAGTGVSSGGVGGRVLPLGSEGGASQGRCSAWAMDNGCGTSRSPQIPEPSMPNSYPNAAPPSCAPAPVLMPMPIHLCSSPDRSDLIDLKEDVMEPSPSPERDAHASGRACRSCTTPKTSSPSPPVSSLAPPPPFSGVVTLSTAAAAAVEATPLHYSGPQGDVIGGGSSGTTAGEISMRGHSRSSSRSPTGEMLVAPVGGPKGRVSVRGDMASSGVSATISQLRLQSPSADGESDQREPRKRTTGWATAASAVPSPETKGGARVLPSPSPARESSVSLSAVSPPSSLGEGRWSNGARSRARAGSKEGEGERHVTEVQRPPQLSPSQQRRGASASSLSLASPSYTSSCSPMTNGQSPASAATASKAAVTNGDVSRPNDFLTPIQRRGGCGPQCTSGAAFSTSGHLNMHRSPLSAALSSSPEGRSVIETEAVESPRSDTEDYMEDEEESTPCMRPPTMLGRRVSSPPPNLSRFPQTGCTEAGLSTAPPRRAVDPPPQLRQRSGGKRDAGLTAPVAAQAVLLPSLASPSHLEPPPQQQQLPELSELDDAIEEVELAGEDNYDTLEGIAAVYNLTVPIIIEWNPYLKKYRPSEPLPPDLPIVLPMSDEDEEDGEGTDSIMHEVDSRLLLKPHSRLENWSPDGYSPSGTSDNSPAPQSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S7P0</accession>
    <name>A0A088S7P0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ubiquitin-conjugating enzyme, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_201120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97606.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698313.1">
        <property type="nucleotide sequence ID" value="XM_010700011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S7P0"/>
    <dbReference type="GeneID" id="22574321"/>
    <dbReference type="KEGG" id="lpan:LPMP_201120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200016300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201120"/>
    <dbReference type="eggNOG" id="KOG0419">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9978460at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97606.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="166" mass="18618" checksum="EB9FB556B5389A6B" modified="2026-01-28" version="2">MSARTVRRAHMDFARLKELASRGSSTIRAVDMADEQGGTASGDAFHWRIRVMPPAESVYHGTTYDILFTLPQQDYPFKPPVVRVLTHIFNPMIAENGAVCEGLLQNDDWKPTTPVMDVVARVVKAIFLEYRTYAVLNEKAAGIMSTTTPEEFQKHVQRTRASDSCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S7X4</accession>
    <name>A0A088S7X4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pyroglutamyl-peptidase I (PGP), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">PPI</name>
        <name evidence="5" type="ORF">LPMP_201670</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698368.1">
        <property type="nucleotide sequence ID" value="XM_010700066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S7X4"/>
    <dbReference type="GeneID" id="22574376"/>
    <dbReference type="KEGG" id="lpan:LPMP_201670"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200022000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201670"/>
    <dbReference type="eggNOG" id="ENOG502S999">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="407146at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.20">
        <property type="entry name" value="Peptidase C15, pyroglutamyl peptidase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016125">
        <property type="entry name" value="Peptidase_C15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036440">
        <property type="entry name" value="Peptidase_C15-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402">
        <property type="entry name" value="PROTEASE FAMILY C15 PYROGLUTAMYL-PEPTIDASE I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402:SF1">
        <property type="entry name" value="PYROGLUTAMYL-PEPTIDASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53182">
        <property type="entry name" value="Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN97661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="277" mass="30665" checksum="4D23CFBBAF13667A" modified="2014-11-26" version="1">MSTSKADIVVFITGYGPFDTVKVNPSTAIALCVVEDLKRHPDVTEVRYTELHVSATSVAAYFEKVENDIAQIITERGAAKVKILLCHLGVHRDTTGVIRVEVQGYNELFATIPDVDGKVFDHTLIIPEDGTTDVFQESWFGKDGSPQFDDLQRLIEQMNDNIAASWQDTMTSTATKKKLMSADKNDEAMVMPVFQAPRWAISRNAGRYLCNCALYRALRLQEKNTGVVYAIFIHVVDPSCGKTEMEGGPIVAYNPSIMVQAVQVMCFMCGLLSLMIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S823</accession>
    <name>A0A088S823_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_202260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698428.1">
        <property type="nucleotide sequence ID" value="XM_010700126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S823"/>
    <dbReference type="GeneID" id="22574435"/>
    <dbReference type="KEGG" id="lpan:LPMP_202260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200028000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_202260"/>
    <dbReference type="eggNOG" id="ENOG502QU82">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271924at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="675"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="581"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="635"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="10"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="323"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="419"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="588"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="646"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN97721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="870" mass="100177" checksum="D0243DAB9C3EDB92" modified="2014-11-26" version="1">MSRMATGDHLKLLKGQLSEKEFRIGELENRVKDLFIEAKELDEKLRIANRNARVLEEENSNYHIRIKSLEKESDTSDVFPLQREAMKLIQENEELRKSLTEAERHVKQMSIRERNSDHGADKRIRELQSECERMQKERLRESKELENTRHQCADLRKRLDDNEETLKSAKELWDQERERYQQKIDELLDFNKRAERPLVTPFARNRNGGVEEPLEQFLLKEEVAQLERKLKEAQHKSWEKEKEWVRTENELRHRISELQVNGSSEGRNDEALFQAMKDQVRSLQDEIQALRYDRRGSRSAQAVPMSLIHASSTVKPAAKSCLLEEWAARYESVSRANDDLRDQADAAKVKILELQNVIDEKVVTCKEMEVRLAAAQKQLEDASHESLTDRLSSVRSTGGYSYGSRATGAPHSQDDARAMIVLKQRVRDLEAELKKLNSAQEQKEAISHIRIKEYEKQIVELLHENANLRDVGRAQVDSEGGDTVINFLDGVMRLTKDKRESVEEVMRLLEFTWDSEDEANRQLRRAKYQGAAMAARGAAKDDEIQRLQKYVSDLESKLRDTEKLAHDNDDLKDTVGALRKQNRGVTSENDRLRKKVGDLEKDKEEVVQQQSAKQNEAKRRVEKLQAEIVDLTRKLTNARKAGSRPVSPNISARSPQPVTRSPRPSARRRTPEAIALSELSVRSTDEQHRSAIPEGAHLAFTVVMLMDVLRNGRPITEPGHVIIKLKSIKEKYRTSVKVLSSVIRFDETFVFYLAQPDQDVITLHVFYKQHGVSREFHIGDACFSMATLYRGVPRQRIAPVVQNPGTKEARRAAQVEVCLQTDDFGKTMEPTEEEVKKDRTSFNELVKKFENSAPEMLHAVDVYMASNELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S971</accession>
    <name>A0A088S971_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_210800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698868.1">
        <property type="nucleotide sequence ID" value="XM_010700566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S971"/>
    <dbReference type="GeneID" id="22574902"/>
    <dbReference type="KEGG" id="lpan:LPMP_210800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210012600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_210800"/>
    <dbReference type="eggNOG" id="ENOG502QUPF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="259849at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="722" mass="78913" checksum="F4FC3DAFE81E8F33" modified="2014-11-26" version="1">MKLAIVSNDGKLAWGSCFASCHGDHVPAAIKLVKKAGDGDKVDPDCVAFSSFDVVRSARLDIKARYRAGDHVALGFNDPDSFFVAAVVRCDTWAVQWAVEKSACLTDASVTQLAVLCANTMCGVAIASSSASSSSQMQYLFVASRFDVPTASRIENKEWRQFLAPPRSIETGLEEEGIASISAFNKNTLLVLTEKGSLALVHLDVRGLKTHPASTAAFYTVQRIQCKLTLASIESRIVVYNDEKECAYAAVYSVAEKAMELVHFHQTTAETATRAGEVVVTVLKVATSIPVDGLRFAGPFHLVVTCLRTKENMQFVSLIPGTGALETIVFDPLTVPHVPIATFYRESTEEFVVISSSQEVAAFAGLTNEQKVASLIETTLTFSAGPFSQASLNKATWGLVSNPFCHYGPQTRRHAEEESGADEEEDLQLLQGAGARSTGRWTPVTLCYALATRRLFLPAVQVAVFAVETAPFLHTRLIKQWHNATTGLKEILGATSTKLSGALALPWNPRHIRRALRLFSQDELSSLLHRVATTIAASECVASPVLYPDATTTAVDIALHTITLARQMGATLKPEDVRIVAIILRAARESSHELLRYASRMELLMESHLQQRAMDRVLERRASACGEGDEVSQSLEGNFYGIAAELQTERTLHTRYTSNAWAQHLGKCKAQYKMEGESAMRLLAAAHNKSENTMERALSDWRQLGSTPHQDPLLNQFEQALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SBH7</accession>
    <name>A0A088SBH7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ER-Golgi trafficking protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_251630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699733.1">
        <property type="nucleotide sequence ID" value="XM_010701431.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22575811"/>
    <dbReference type="KEGG" id="lpan:LPMP_251630"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000048400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_251630"/>
    <dbReference type="eggNOG" id="ENOG502SI02">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="437922at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024420">
        <property type="entry name" value="TRAPP_III_complex_Trs85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975">
        <property type="entry name" value="TRANSPORT PROTEIN TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12739">
        <property type="entry name" value="TRAPPC-Trs85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="792"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1133"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1631"/>
            <end position="1663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1725"/>
            <end position="1755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1778"/>
            <end position="1807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2014"/>
            <end position="2039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2061"/>
            <end position="2081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2210"/>
            <end position="2258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="811"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1140"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1727"/>
            <end position="1739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2061"/>
            <end position="2076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2210"/>
            <end position="2228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2239"/>
            <end position="2258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2258" mass="243633" checksum="B13505202CBE90CF" modified="2014-11-26" version="1">MSLEEWVEQRYARPVVVVEGSPAADAICARNGMDLIHLLRLHSVYRGGPLSARVRDRSDTIVCNQFGVRLMRTECVPDVALSQVTRHTRRLLRNAAAIDLAYGEQLDAALAEIVEKNRSRHNGSLPRPVRPTQPSTTSSSFEPSTIIGGPAAVPTLLERACPTWHRSFIRDFHSLVRCSSFDTIDYPIGVLFAASTTEAGGVEGIFQVFRAQARRIQELCASLPGMDTELHQYYLILHDNTSPLSPSLSTARQILTAVQQLYGVNYCALVKVNSVVDPRTVKNLDPSMWIEASPAVMDVPSAQALHQASAAASSLPSGPPALSFRTLHGTCGTWPNSNTAIITGCYMSPEDVTEVHNVMAYYLSQSLFRFVERRLSMLDVSVQDRRTTTLGKMAAWFKGKDEVRPRTAEVVNKPNGFDSPALPKYVAHSLEMQMRHCGDLSLALHDLKGAVSYYRMCIEELLETLTLRPYNRALIAACQEGIGVAQLLQGKLATQSLTPWYTGVTSATQRVSSQTNRWEVAWNDYLAAGTQTYATRIAFLLYESSRVRTPPMLDRCHAILMHLQRSGILRRQNLLSGVVNDMMAGIAAFTNPPFSAGLAVTLSIPRDYPVYMSLRQFAQRLQQAGALYRADNSLEQALRCYLRVLELLRVIDPQETWKTLTEHLYLTVGQLYTQLGQDVRGIALRSAAIAQGTSLYRNPATAQQAFEDFWAQQKRVLSSMGYTLCPHMPMPRILRDSFHVDRNYYSTDALTDDAAHKMSETTAETEWRSMEKHLKKSYTETVLRAHPRYRFPAFQGGSKDRNHGAAHRRQSQSGQSTHDGCRHTTYNSHQRNAAVRAHGGALSPQLPAVSREAGAHQDDDVLAVAGTTSGSTAQLSRHYTIAKAEPLVLNFVMENTVGCSIEVTELTLLYLDYASPEQLWKSSMTQAVRLEAGARQRVSLPFDLVSEGEYAIIGLSWSLLGQEGYYYFATRESRPGCPESLYEYAIEHPMPSLDAPENIQVSVTSSKACVTATFRPPLPEHLYDGEYFHTNLIVQNTSAQQDAAHVVLQRSPAASHLMYIEEFGRLQNLKREAPLVLAEHLKAQETRTFAVTIRPQHRRGDTARQNTPNYFFLLLAYLPEPLPVPEMSLPGSASVPGVETSSITPPTGSPSSTAMVSPTSPLHRQFHTPTAPVVALSAASGPTIMVRLHRLLRRCEVQPVVAMHSTVLPPANASLQTAVVLTVKNISPTAARTPISATLVTAIISKGGEPTPITPTSATDVVQAVPVSSSGNPPSPRHTHSRGLSYAPVRIARVLVVHSPRWGVECKGTEELFADRAMHCLLSHGDSLTLPLLVKRQPRAAAGEENTTERRILLSDDDAATTTTSTTGVQCPYSDTTCMALESAFPSQEGAKAVSNHLGTSISQSERNLFFLQTSCLGPGRVGARPSTAEAGGGLAFYADKAGQQEAPKTAKQRQCDEVDEERRLCGGAIEQYTPLAIAVAWVREEDGSVDGRERHNGGGGGLGLREGQAFLFVDPIEHVYQTLAQQQRRQAEQESAASLHPALSAVRAGVSVEQTQQELCEAMLVRYASLKPWQGALVSHVHVPRVVQVSKGQGSNKTVAAPVPVTLRCLSLAPVPLLVTAEALPPSVPHRSLSYPESVRDGGTRGNQPASPATPPPLFHPAAATVSSSDVPVLFVGKTMHTFLLMPSDEYEVKFTALALRPGVVDFQGISLSATPICYLHSTTGKKADDDGGADEVRGTVGPPPPPQGGNAATTVQPLMFTGMTLPSLIRALLSRKTPSAEPRTTAHVLPSGQQLSEHERSDDEAVECSSAERCGRQRRLQGHLAAAAHRSVMTLIERHGTRAAELVHQLAPLGPAGGPTVSQVMPRTAPALTRVIVVEVQAATQPDVGVSAGATVQKAAPAAAPDATVSDSSTTAAMATHTHDPIRKFFRQLENFETELQRARLSNPSDPYALQYVYRPTVKMAEEGTSRAAYYTSNRSFTTSMSTTSAPAPLISSSWSTLLMPAAALSPATDNSVTTSGGGVAEPGSVGDSRATDRVSATSRKACSVARPVLTTSFSAQESSFSAPSPTQQPCDDPLEPSSPLHLPAVAFERRATEVALTLDIGEVVSDKYTAEPATCEDSDSPCVAGIKMQVDLMSPLQQLHSNNVDLAGAAGMSDDTEVLMSAAGVDDPEAWASPAERDAPATLRHSQGSEHFSLEASVYNPLSQPSAAGTAAASPPSFTSGVVGGIPPPSPSSSSPTSSGAAEASATTPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SCK6</accession>
    <name>A0A088SCK6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_270590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700148.1">
        <property type="nucleotide sequence ID" value="XM_010701846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SCK6"/>
    <dbReference type="GeneID" id="22576235"/>
    <dbReference type="KEGG" id="lpan:LPMP_270590"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270012700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_270590"/>
    <dbReference type="eggNOG" id="ENOG502RZDP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265282at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="261"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="678"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="817"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="534"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="681"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="979" mass="105902" checksum="1FC996B770CE2539" modified="2014-11-26" version="1">MPVKINDSPNTLSSPLSDSVDLGNFPIPTPLVSAGWLDAVHSARPPTARPPAVASGASNTCAAAPLRLSSAAGKTHAQRRARNEHTPTASRNSAEMSAMLSPIPVNADDSDVPIQQLLSPVEKMTRPGNYSTSKSLARGSTATPAPPSARTQLNARRSTSAPSRQASWGPFPAKSASEAMPAPPTTTVLPPPPVASQQTPIGDSHVAAANTLSTTAQLHSDDDTIAFADGSPQRHDQQSTTPYSSALMQALSRTEGAAALTSPWASATQRGGPSAYYSEGDAGNGSSSDVPPDMYVEAMKAKVAKQQWMALERARQEVLEEARRRRDCPFAPQVSRYAARIQRPASLRPENRFSAEMIRRKQWVAKRQQEEVERELQSCTFRPLTLRTAQLDPTAIESPRAATTVFHDLYAEAENRRAFEHDVKPQLVHQLEEHRRSSPAPLRPGQLAEVVERLCARGVVRSGVVAVPQKDNTDGAPYEGSARTVECPGVPPDVHHPTLSLETKRIVAVQVASGVRDGNIVKQLYRHSEQGVVRGQLKRELDREQERLARAEEAIALAQERKRLQQEYYRSVLVAKFRALARHVASAQHCSYRTTAPQSVVQMARAALDILSTEEAEELLGAVEHCGRHRLTEDEFAAVVFRYLAEQEATPVQSALLRNAPPPLRVFRRAASAATLKRADSAPGAAASAESSPSALPRVKREKPDPEVIGQVRARRAQQLAEWTKESQRQRPITDGVLADGADYTFQPAPRRLIPYACRPDMSVPVKSTKSEMLRRAHLSARMYGIAPALGVDSMARPLSAQRLTPSRTTTRELFSRGTLNPASLWTRERSRSAAARSEAQTAPEGGAAALTSTVSGPVVTPRATCSRPCAGPAQALSALPTSRKAPAEAELQCHSYVATLVGRSAAAPRQRASMSKGYPSALAARHPCASSCHGRGNLLTASPSLAEQIMHSTPEDRARIGHELLLRQIREHQRRSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SDM2</accession>
    <name>A0A088SDM2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-directed RNA polymerase-like protein</fullName>
            <ecNumber evidence="7">2.7.7.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_282180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="7"/>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700558.1">
        <property type="nucleotide sequence ID" value="XM_010702256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SDM2"/>
    <dbReference type="GeneID" id="22576663"/>
    <dbReference type="KEGG" id="lpan:LPMP_282180"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280028100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_282180"/>
    <dbReference type="eggNOG" id="KOG3438">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="510325at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07029">
        <property type="entry name" value="RNAP_I_III_AC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.10:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008193">
        <property type="entry name" value="RNA_pol_Rpb11_13-16kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033898">
        <property type="entry name" value="RNAP_AC19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF28">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01154">
        <property type="entry name" value="RNA_POL_L_13KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="6">
        <location>
            <begin position="48"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN99851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="137" mass="15336" checksum="9B739AE2EE267318" modified="2014-11-26" version="1">MASFHPRDAFILHQEHIQRMNEGDEVDTSEEQKVHIDLQRVTDSESTAVVTFSHEDHTLGNPLRHVLMQNVAVTSAGYAIPHPLEPKMLLHVQASDYAVEAVAHGLERLAEICDDTISSFDKCMVAQHRMAVSARPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SEU3</accession>
    <name>A0A088SEU3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_300890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701122.1">
        <property type="nucleotide sequence ID" value="XM_010702820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SEU3"/>
    <dbReference type="GeneID" id="22577143"/>
    <dbReference type="KEGG" id="lpan:LPMP_300890"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300014100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_300890"/>
    <dbReference type="eggNOG" id="ENOG502S21Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="263568at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="456"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="595"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="148"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="456"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="639"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="772" mass="85698" checksum="383FF10687FFCDA1" modified="2014-11-26" version="1">MSAVNALPSPDGDRLGSVIVDENSDAERELCGMVDMMIATSTSALQRIAKDVTNSSTAFEKAAPLFQANGIHIFSGEPDESASSTVSPPAVEPNLRTQLAHCRDLLRRVDSERRHVRRHCIYLQKEHELRHAEIKSMHRYSMESHQRSLMLENQVAEERQRRKRLEDEVDAQTQEVMRLRRVLRALPDNVLKSLSPHYPADDAAAEVVQTLAPDRRFEEAFRDKMNSIVYKRRYHQASAMHQAASEQIEMMMMEQQDPLQVASRWPYVGEDVTAVGATLTESVVKQEWRRSFNGASDLLESPSHGVGESQLEETIKPTAASTLANCTLMQSVLAFPFQLPFTTATPQDAYIKFLVYHSAYAEPLTQLREHVLRLSSRLKTAQDAGLRALYTMFTRVLHLLGSSPAQTQWRSLYERQMEKMQRTHRELLYAVIEQANMAAIKIPELERIGGAAAARREHTGGVPQRRDVGCSAQESTTMEKYRSSQLKEELARLKLHSLEVEAAAQKEKEEMTRQRSTARQDALQALRSLKALSKCIVWSVRVHGAADDAVYDPFAQLPDPLTEEVLDDPRLASKTTEATELTVSYVRLLAYSHGEGGRGKCAQPPLADPRAATLSSSQMSGKDGTREGAARDTTNIFRTASGATASSSSPKAQSSRRKSAPSAVQALRRRTRSSSSRYSDRRLSTPQLPPVARTPALSESTKDCCKRQSSGDAASAPFPPARGGPSLTKSSTVLSFHNTVSSQEARVKESCSTPQAAVTIIDLAFRESDVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SFI9</accession>
    <name>A0A088SFI9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_303450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701367.1">
        <property type="nucleotide sequence ID" value="XM_010703065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SFI9"/>
    <dbReference type="GeneID" id="22577398"/>
    <dbReference type="KEGG" id="lpan:LPMP_303450"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300039400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_303450"/>
    <dbReference type="eggNOG" id="KOG1164">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14016">
        <property type="entry name" value="STKc_CK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="34"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO00567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="391" mass="43931" checksum="4E7861B60FC0E02E" modified="2014-11-26" version="1">MQASSHRQIRGETESCATGATNKRAQDVLIGGRFRIQERLGGGAFGEVFKGIEVNSGYPVAMKMELTKYDCRSHLNLESRIYKKFNECPVTIGIPKSYYCGRVGDYTVMVMDLLGPCLEDLFDVCHHKFNIKTVCMIGIQIIQRLQYLHSVGYLHRDIKPENFVMGLGANSHVVYVIDVGLSKAWRDSKGKHIPYAEGRSLTGTARYVSINTHQGIQQSRRDDLESVSYMLAYFVRGSLPWQGLKSPKRDVHFERIRDIKIATPPAELCKGCPHQLTDYLAYTRSLEFEAEPNYRHCVELLSAAIRDMGEEYDYCYQWINGSEGESTSDARGSVQSPRVSGAHSGVAVRGSNFMTSSVFMGDSAANEMSKSQPNSNFIEDMQDIYGLNDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SG09</accession>
    <name>A0A088SG09_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_311410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701532.1">
        <property type="nucleotide sequence ID" value="XM_010703230.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22577567"/>
    <dbReference type="KEGG" id="lpan:LPMP_311410"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310020100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_311410"/>
    <dbReference type="eggNOG" id="ENOG502SHE2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264516at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="683"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1320"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="685"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1326"/>
            <end position="1339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1537" mass="164580" checksum="F6B23535F05F8427" modified="2014-11-26" version="1">MPSERRLVSEVRFVDAAGDTVDDARRYSDDALNILPATASAVLRGRERRRVVWPHLPGASGASPWWHTLPQFHARTYFEHKQQRSVTTAAAMATGTVPSGLDNQGFLCDFSSLPDYPYTGTSFHSAAMRAGYLGGVLVGHLVSLVPSTGSDGEQYNPHRPSAVLPRADAAVQGGARLPRRRVLHWEVGVEWEEDHRRKHAATSMYRKSSEDETPKYQKKSHFGGSWMHSHWWFNRPLVLGQVFVSPSRLPRCHSAHEDVRSHIEGDCTRQVSHDPTSAAAAAPPSTSLYAYGGHPASLPLSMAEGCSACTSCSTRERETTVTTAVVPEGVTRRSDTLSSSPVQGGQQPRQCCTAFLSTVHLYECRALPALPSLFVSATSNSMTQWWSGFLRCPCCSHVRILDINLEGTQARKLEGWATVVVPASSSGQAAGEAPPPSASQPPRELDFQVSDEGSAPSSAHSRRPLLECLQPQPQTIASEADYASPASLHLRPSLSRYLTEVHLISSATLHDISFLGELPALRLADVSFNPSLTDAGVRGLCQSTSLRVVDVSYCPHVDAAAADLAHCLVELEELYLSGTGLTDATLRTVVLHLGFSGGTPHDALLVTEAGIPASRQARHSPRPNSGKWMRVLHACACRRLRNPHRVLASVAWIRQNQMRQRGSSVEFHGQSCWTGLQELRVSAVGERHHESDQSRSRSSDHSGTQSEESDSEVGAATERVADALDEGAGLVPSLLEGGQEEAVPPTPGEPLTIVSPSLLPSEGTAARVEGVGAAAKVMPAADVPEVLTRPPFHLWERLTTLVFTDIKFRCALGDVSQLLSLQCLALWRCSVEEDEPLSVREGAHRPWLSGLEHSALLHTVHLDGCSASAIRDAGSLQVLARLPSLQNISFSHTGIRDADLDAFVAALCQSGATSPQYPFHRLCLRACGRITHASAVALLSSVRSLDLSDTGVRQEVLNALGELSRVQRSGGSHALQVLNCSACWLIVDLSPVAHLRHLHWPDVSHTPVTTAGVAALCFCSALTHLNLKNCAGVSHLRDVIAIAALQVLNAQGSGLYDGDDEGEEEGTDFITGASRVAEHSEDHSFTPGTPLCNFIIPLPHHDGGRPPPARGRSRLAVVDVFPGDDVVLYTSSLHTLLLSHTRVRRIHRLGLLPSLMCLDLNNTAVTDAELVKFVFTGVMVADKRASDARLGLAQTPPAVVHTLHALRRNECLGQGCRGPPLRLLSLQFCRGIFTVGVLGLCPHLTKLDVSSSNVTSQGLHGLHRSTSLVQMRLLACKGVHDIRALQLIPSLVEVEGSGCNVHSGRITGTGVRGGSGIHAAAGAADDGGKRGAEANESRGRLSPPPLFAHGGDVPVMTPPLLHSDLLQESGLKADDIAAVRRVTEGLPLPMASLVQGSTSPLSCFPVLACGFQRLVLDGCVNIRSFVEFSVLPSLLELSLCNCRGITAASVAELIPLSQGCPRESGTASPQSLAVSSVLPLSAPFAALQTLRFSSCRNLTGSLAGLELLPQLRCVHVDRCGITSVSEVVPVLQNRVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SJ91</accession>
    <name>A0A088SJ91_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_342660</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702692.1">
        <property type="nucleotide sequence ID" value="XM_010704390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SJ91"/>
    <dbReference type="GeneID" id="22578771"/>
    <dbReference type="KEGG" id="lpan:LPMP_342660"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340032700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_342660"/>
    <dbReference type="eggNOG" id="KOG2615">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="419616at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF15">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO01892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="266" mass="29286" checksum="60EDDC81B1ED29D0" modified="2014-11-26" version="1">MAFVLLNESICSTMLLPFVGLLVAHLKGVSVNEAGYFSGILIGVFMLGQVVSSRMWGWVSDKYGRRFPLISGLFTSGFMMLGFGLSTSVWMCGIFRFMHGLFNGNVLVAKTMMADITDKTNAAKGFAFVSLCYGIGVLIGPTLGGTLHFEGFFWSTFDRNGLSPALTSLTRVLWSPYAHKHRREGLQRFVVGDGHHPEDPSASQGVYVGEIHISLVYVDVPLWSLLPSMRGRTTNMRRRKTVMLTIDLKRRLMSLTQRAAGGTSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SJG5</accession>
    <name>A0A088SJG5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_343360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702762.1">
        <property type="nucleotide sequence ID" value="XM_010704460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SJG5"/>
    <dbReference type="GeneID" id="22578841"/>
    <dbReference type="KEGG" id="lpan:LPMP_343360"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340040100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_343360"/>
    <dbReference type="eggNOG" id="KOG1786">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10018316at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017073">
        <property type="entry name" value="HGS/VPS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46275">
        <property type="entry name" value="HEPATOCYTE GROWTH FACTOR-REGULATED TYROSINE KINASE SUBSTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46275:SF1">
        <property type="entry name" value="HEPATOCYTE GROWTH FACTOR-REGULATED TYROSINE KINASE SUBSTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="81"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO01962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="298" mass="32271" checksum="66516F3123C82883" modified="2014-11-26" version="1">MGEKQSKGYWQEDEDAPTCNGCGCVFSTTLRRHHCRNCGYVLCGGCSRHRAAIPMRGITEPERVCDACYLALRNSSVIGSSLSRGNPEPIVNPSETPNRPAAWTAGGTTCGPSADLRASDAASLAAAAQSSSAAPELSEEQREAEAFYHNPYGGAAGGQGNSDTTGAADARQETINPEALEKKRLIQRWNTVRQATVYVDILVQQSERVEPDTAVEYSRETEALILEPELPINQLGTRMLPLPRPTTDSARYLVELVTTIGVTGTMLERAAADLTRRLVTRIPARADSRESPDRFVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SJL6</accession>
    <name>A0A088SJL6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4E-interacting protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_343850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702807.1">
        <property type="nucleotide sequence ID" value="XM_010704505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SJL6"/>
    <dbReference type="GeneID" id="22578890"/>
    <dbReference type="KEGG" id="lpan:LPMP_343850"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340045800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_343850"/>
    <dbReference type="eggNOG" id="ENOG502S8J6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267997at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="39"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="244"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="500"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="735"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="181"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="305"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="323"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="437"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="459"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="508"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="552"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="580"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="613"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="638"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="652"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="741"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="758"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO02007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="772" mass="80378" checksum="EC7CE80B41A8DBBC" modified="2014-11-26" version="1">MPPVRTMYTREELLRIASLASAMDLGPEVLRKFDVIEVAEPVPGPKRRESEPNFKSSVLTDNFSTSTAITTTGPNGSGNTGGKANHSSGMNGGGSNNHTGSSSTPGYSAGGGRGGDNRRGGGNGGRDDSGSSSFKQSGYDRFAPPEGRFSRGNRNQETFEEGIEYELRQSALQKKRVAETMEREDRKGEHLRQALEKFKQEGNDAAAAEAERETDEIERLLAGITMIDDAPKTVVRSRFFSAQGPMTASAEPPTAMPLPPPPPAATTLSFGTSASSSAPATTGVPQASVLATPAKSGTPGYATGPWSSMKSDSNLWSTAPSMASALKQSLQQPSSPAATSPPLQIRSQQPALQQSQPPTRPASDPQPGKSMGTVAAATSTNSVSAQSASGSGGFGVHAPAQASLPAPPQGSVLGSASGNSNTGIGAAIGGKAGVPTSAGQTQGPSHTSPQTPSPNLPQASRPAPATATKPAPRSGGSTGVPTGAWSAAELEFLLKKGTAVKSSAPALPSSTGASATTAQKTQPITAAELESLLMKRARQGSGATGTGMSTLPPSPPQFQQQPPPQQAPLLFANPAKTPTMPANSNPAVAPLSLQQQLPASMMAPNGAMLTPKQPLPPPPPPMPSQMPTHPQPQPPHHSQPQQHQQSPWVAMPRPPQAPPASQPSGNGSPMHNTPPLQPLAAKMQHPASMMPNGLQMPMQMNPQGQYFVDSAQLQRVYMTGQPMMFRRPDGTVFMQTQHMPQPQPQQAPPHPQQPFNPFGTNAQFLFQQQQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SKC1</accession>
    <name>A0A088SKC1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_351250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02262.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703062.1">
        <property type="nucleotide sequence ID" value="XM_010704760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SKC1"/>
    <dbReference type="GeneID" id="22579154"/>
    <dbReference type="KEGG" id="lpan:LPMP_351250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350018100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_351250"/>
    <dbReference type="eggNOG" id="ENOG502SNTB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264983at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO02262.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="349" mass="37972" checksum="FFA9A60BAEC18845" modified="2026-01-28" version="2">MNPHCRPVTPFLSISSPFSASVQSGTFLLASLQHLMSSSQRGHASSSLHVVTHELPPLGEVGAASPLQAGAALAQGTLAPAILREVSVLPSLVEEGDTSEEVHLIDAPATTAANSISTAQVASPHNTRAPTLPSTPVAHRASTRPVEMYALEEQQERSALENNQASCFETILAREVSDYLRISYHQRMAARQPTEYIGGNAPQNLEKEARRLHDSIRARMKAAEAEHQKFMSIYRPVEQVQLSTADERTPRSQPMLSLENQAEVKLATRRISCGTPHLSSSTSSLDGLFSVNAPPRQLSLDTRRMAPSEAQKGNNPGVRSEIQRQLRLGRPVVHKAGEWTADPLFTELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SL55</accession>
    <name>A0A088SL55_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_354020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703337.1">
        <property type="nucleotide sequence ID" value="XM_010705035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SL55"/>
    <dbReference type="GeneID" id="22579430"/>
    <dbReference type="KEGG" id="lpan:LPMP_354020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350048200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_354020"/>
    <dbReference type="eggNOG" id="ENOG502SA30">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272574at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="133" mass="13880" checksum="A850A4E02DE357A0" modified="2014-11-26" version="1">MMLIIAAAAAIFILASGAVLLYGAASILAGGFFRLALGALLMGMSLSVIFSSTANILLVTFSRYDLEQKPPILFLRSFLAAMGQPTLTGVIGLSLVALISMAASKVRVMVEEMDILIRSHAAYVARSGRSAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4H4</accession>
    <name>A0AC62A4H4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oligosaccharyl transferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3420060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="XUY36767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="765" mass="84988" checksum="B65E2BB1B3B26937" modified="2026-01-28" version="1">MRVRSIDVYGYLFHRNDPWFNYRAAEYMSAHGWSAFFSWFDYMSWYPLGRPVGTTTYPGLQLTAVAIHRALAAAGVPMSLNNVCVLIPAWFSLVSSAMVALLAHEMTGNMATSSISSILFSVVPAHLMRSMAGEFDNECIAVAAMLLTFYLWVRSLRTRCSWPIGILTGIAYGYMVAAWGGYIFVLNMVAMHAGISSMVDWARNTYNPSLLRAYALFYVVGTAIATRVPPVGMSPFRSLEQLGALVVLLFLCGLQACETQRSRLGVERFSTEGVSLLVRIYAAFFVGIVAVVAMAPAGFFKPLSLQAHAMIAGAQPTGNTLVDMLIAKDASSLLVAWELLLFPFFGWMVGMGAFLTKLVQSFTYTRSFMLMYGAVGMYFASQSVRMMVMMAPVACIFTALLFCLALDYALGALFWAEMPPSIDSDAQQELQQQTAEAAKTKKRKQEEYTTMQVKMISVRMMPLMLLVLLFRFSGFVEDVAAISREIEVPGIVFPGSMVQGLSDDMIDDYYAGYLWLRDNTPADARVLSWWDYGYQITGIGNRTSLADGNTWNHEHIATIGKMLTSPVAEAHSLVRHMADYVLIWAGQSGDLMKSPHMARIGNSVYHNICPNDPLCSRFVFQEKRKIAPARSGRHINLAKLGDDEEETQNVEYEPSPLMAKSLIYHLHSAGVKEGVTLNDKLFQHVYTSAHGLMRIFKVMSVSEASKKWVADPANRVCHPPGSWICPGQYPPAKEIQEMLALRYTSLKDLVDSMSDSEREGTLNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4S0</accession>
    <name>A0AC62A4S0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA polymerase eta, putative</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_210650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="XUY36872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="791" mass="84853" checksum="14E3EED36B4B7701" modified="2026-01-28" version="1">MSSGYGAGSTGAGEDGRGRSSLQVSSSPFSTDSMRCIAHVDMDCFYAQVEAVRLGLDCRVTPFALLQWGNFIAVNYPARARGVKRFCLSPDEVRRELPDVQMSHIATYAVGESEYCYPEAPRINTHKVSLEPYRHASRQIFAILRSEPGVMVGKAGIDEAYVDVTEAARRELAEVRAAAAGASLDPLVDVMEPSTRLIEDRRAEMEAWLCARGTSLAAVFDEPMRALVRGECGAGLEGSRAFCVGADDAAYAERCLLLCAASRVVHRLRQRIYAELHYDCSAGIAHNRVLAKCISARHKPNQQTLLLPDRGASALFELPLSGLRGFGGKLGAAVSVVCGGVTECREAWLVPLAQLYKLDGTHDVGVGADAEEDGEGHVDDAYANCRRDTKASNAGGSGSSTDAKSGTGLYVFYRVRGFGSDTVADPVLPRGMRASKIFHPMCSSWSAAQLWMAPLAGELWHRFSEYESHYYKEGRSLVVVFRTYVTPEQVRRGQHTRSYRAQAPLPANVRDATEIADIGLREFVKLMREVTREEKGGEWKSGSTTSLLSPHLFTNPTNEVPDAPTGIAAPANDVSAMPPLRFLELSIIGLRVRPLPPTEGGNGGTAGGTDGGTSASTQCSLADMFAALSANATASAGSKGTRTAVVGGGVLRKRHRSGSRDADVTRGLRQEVVVEIDDGNEDESVSDDCVDVDVNFGEAAEGVKSDASFQRGQLARPAGASSPPLKRTLKDPFHRTTMTTDVSAAERAHVPTSAARQVTTVCVEEDDVTVCVTQQGCVSITEVSSEDETRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4T7</accession>
    <name>A0AC62A4T7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Iron/zinc transporter protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3120060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="XUY36700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="426" mass="45069" checksum="1309811F1F1D444F" modified="2026-01-28" version="1">MTAPSLSIEESTRYLTALGYRVSAPLYAEVATAANMEGSGRSLCEGFTGSYSLGLHIGAMFLILFVSLLGTAIPILGKWIPWLVKFPFVFSVAKSAATGVLLSVSTIHLIYEGAEAFSEECIPAPLKTYGPLYFLFALIGVLLMQALDMQLADIAERWMKAKLKAEAEETNTDNKDDKACRGLSPAVEVGVASGPAQSDEALIDELEGVSAEGNAKATVLVASLKDCEAPLSPKHQHHSDEAAAHGHQHLSVAPPPDMGSITRVISAVCMEFGVTLHSVFVGLTVGLTTDSELKPLIVALVFHQLFEGMAMGSRLADAKFRTILDIVLALVFAISAPAGMAAAAIAVSMSPAAMSGSGFATLVAVLDTLCGGILLYLAFTLLLGDFVADVRHYCADGQRYRIAKKITLFVALWVGMGLMALVGNWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5J4</accession>
    <name>A0AC62A5J4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chaperonin HSP60, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3520240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="XUY36856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="562" mass="59499" checksum="E49831DE9DD84FD1" modified="2026-01-28" version="1">MFRSAVRLAGKDVRFGDKARRSMQKGVTRAVAAVATTLGPKGRNVIIEQAYGAPKITKDGVTVAKAIEFKDPFENMGAQLVRQVCNKTNDLAGDGTTTSAVLVDSIFSEGLKSISQGTNPIDMKRGMDRAVDVILKSVAQQSRPIKGEEDIVQVATISANGDEEIGKMIGQAMEKVGRDGVITAQDGKTMATELEVVEGMSVDRGYVSPYFVTDAKAQKSELEDALVLMNAKKIQNIHSLLPALNHVVRSGRPLLIIADDVESEALTTLIFNKLQGKLKVCCVKAPGFGDNKTAILQDMSIFTGAQLVGDEGTGLELDSENFDPSILGSVKKVTVTKDDTVLLNGGGDATAVKERVDLLRELICNETSDYSRDKLKERLAKLSGGVAVIKVGGGSEVEVNEKKDRIEDALCSTRAAVQEGIVAGGGTALLRASKKLEALANDSSLTRDQRTGVNIVRNAIRLPAMKIAANAGKEGAVVVEKVLEAAEESTGYDAQNDKYVNMFEAGIIDPTRVVRVAISDATSVASLMMTAEAAVVELPKEESATAPMGDMGGMGGMGGMGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5M9</accession>
    <name>A0AC62A5M9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Elongation factor 1-alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1720050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="XUY37095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="449" mass="49058" checksum="C7CA18E3C4A6A3F4" modified="2026-01-28" version="1">MGKDKVHMNLVVVGHVDAGKSTATGHLIYKCGGIDKRTIEKFEKEAAEMGKASFKYAWVLDKLKAERERGITIDIALWKFESPKSVFTIIDAPGHRDFIKNMITGTSQADAAILMIDSTQGGFEAGISKDGQTREHALLAFTLGVKQMVVCCNKMDDKTVQYSQSRYEEISKEVGAYLKRVGYNPEKVRFIPISGWQGDNMIDKSESMAWYKGPTLLDALDMLEAPVRPVDKPLRLPLQDVYKIGGIGTVPVGRVETGIMKPGDVVTFAPANVTTEVKSIEMHHEQLAEAVPGDNVGFNVKNVSVKDIRRGNVCGNSKNDPPKEAADFTAQVIVLNHPGQISNGYAPVLDCHTSHIACRFADIESKIDRRSGKELEKNPKAIKSGDAAIVKMVPQKPMCVEVFNDYPPLGRFAVRDMRQTVAVGIIKAVSKKDGSAGKVTKAAAKAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5W9</accession>
    <name>A0AC62A5W9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histone H3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1620670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="XUY37078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="66" mass="7238" checksum="D87F239EB5F19D1A" modified="2026-01-28" version="1">MPCARCRACRRRGGPALPEQRDPGDPGGVRCVADGCHEPGQHPREACVTVRPKDVQLAVRLRGERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A659</accession>
    <name>A0AC62A659_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amastin-like surface protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2020910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="194" mass="22191" checksum="6A5C0B5FCE518DDD" modified="2026-01-28" version="1">MEFNPFIIVYAAIQFIAFLLVVVGTALDMFRLQSRENFEDRPCITLWGLKPYCNSIVYSLSSDERFSLCPVRRKRFHMAQILAVVSVGVYGTAFALGVIMLYCCLHLRWVCLLLNIVGFVILPIPLALMVLSYKTDENSLCPKLRDDYDFGVGFYIFATAVGMDFIDIVFLLIPWQYDYLDVTCNSKEGNSQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A690</accession>
    <name>A0AC62A690_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Surface antigen-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0920315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="XUY37352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="197" mass="19750" checksum="FFE0ECB643C9B829" modified="2026-01-28" version="1">MTSTRNKFLLALVALVLLATYAAAVKGDCSVENCATCLEEDATQCAECNNGYRPTDAGQCEAIPCDVPNCATCAAGSTTQCAECKPGYRPTDAGQCEAIPCDVPNCATCAAGSTTQCAECKPGYRPTDAGQCEAISCDVPNCATCAAGSTTQCAECNADYQLTTEGQCVAASDAAAAPHSGVAAVAALAAAVVAYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6F6</accession>
    <name>A0AC62A6F6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Leishmanolysin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">GP63-6</name>
        <name evidence="1" type="ORF">LPMP_1020130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="XUY37365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="584" mass="64089" checksum="28FE3289E0B9A03C" modified="2026-01-28" version="1">MSRDRSSTHRRRSVAARLMRLAAAGLVMAVGAAAVWAQAAGHHCIHDRLQTRVLQSVAQQRRPPGSVSALGLPYVSTGPISSAHTVDWALDDSTSPSVAHSADWDTMRIYVSYADLTDPDYYCSYVGQLIDNHDGAIDICEAEDILTDAKRDILVNYLLRQALQLHVERLKVRRVQGSWKVTGMEGDVCGEFKVPEAHVTVGFSNTDFVLYVASVPSEPGVMAWAVICQVFTDGRPAVGVINIPAAYIRSPYDQLMTRTVTHEITHALGFDLTVFEEMKVIDEVSNLRGKPSAVPVINSPTVMTKAREQYGCASLSFLELEDTGGASTAGSHLKGRNAKDELMAPSVTAGYYSALTMAVLQDLGFYQVDFTKAEVMPWAHLASCDFITKKCMERNITQWPWMFCNTTDVVLQCPTDRLAVATCKITHHEKPLPLYFQYFTDHSLSGDSTLMDYCPYVDTYPDSACDQDPSTAPEIFKEFNLFSDASRCLDGTFRPKHSTGLSEQYNALCANVKCDRAHRTYSVQVYGSSGYVACTPGQRVELATTSAAFVEGSYITCPPYVEVCQANIKGVINFEGDAADTAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6K2</accession>
    <name>A0AC62A6K2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amastin-like surface protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2020700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="190" mass="21197" checksum="2AF05B4272D9C9D8" modified="2026-01-28" version="1">MFATPIDMFVLKPHFRSGSTPAVTLWGLKNGGFGNGNSQSLEELWSRCLNRLMRFRTAQALAIVTIVLYGSAFALGVTMLFCCSWLRFVCVALNIVGAITLGVVWGLMVVTYRTDDSRDCVRESFLSTYGAGFVLFVIAWVLDILNIFVLLLPLPVTVFRELDGANDKSEKTSKGESEERSTQQEDEEYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHB4</accession>
    <name>A0A088RHB4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_030330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009372">
        <property type="protein sequence ID" value="AIN95268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700976.1">
        <property type="nucleotide sequence ID" value="XM_010702674.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22571899"/>
    <dbReference type="KEGG" id="lpan:LPMP_030330"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_030008300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_030330"/>
    <dbReference type="eggNOG" id="ENOG502SKEY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267894at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="657"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1081"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1171"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1310"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1442"/>
            <end position="1559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="657"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1085"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1185"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1223"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1321"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1449"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1462"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1522"/>
            <end position="1531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1538"/>
            <end position="1559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1559" mass="161324" checksum="2E795C7A4AE7DD40" modified="2014-11-26" version="1">MQAHTSVARNGTEDSCGRAVDTDGGDSNTLGDVSAPYYPPSRPTPPTVIEDANRHEDSRHPKSRDEKVGSNTEAAESAVATVENSRREGSYSAMKSATLLPSVVRVQSWADTTSLIPSYRTIEKSGAAVSPGAAHDRVDAPPFLFTPERMPPSFRERALSPLVRGSAAVHVQPGALAEEAGQRVAHTDTGTINAAPSSQQSVPLWKHGLYDAQQLTPPSHSESLAGSRSPNRRVSHNEVCLEQRAPATASALRDAERHPISMNAAVPLSWRSHSPSRTEPALGPDIATSTAVDAAVMPTSEGVTDEERLTPSVSASLYVKEQLPLPGPSSSPLHDSGSLVNSPGTSVSALARFGENPSCASPVSTAFLLATTLPWASSTATVTPVVPPHSPTALSMSSVPTLSPLATSPPSWSTSTLVLPSLAHPRPLQVPPAPLPQHQPQHPVFSSAKMASPVSATEGEEKSGSVGEELLSWYGNPHTPVSDPENDSSDFFSAPGQLFAALCSPLLSKYSVGNGDLSAFGSPAAAGLTARPNSPSLLPEAPLLTAGTSLAHPLGQPPASLPPILSTAPAASSTSLSLLSPISAVSDSFSSGSGGNDSTGGTGGGGAHDFRSPFTFRTTPLASVVTPEVRHHQPHHPPMVLPHPCFFHRPTFLSLVTPLSPQQSPTQENSFSLPPNPPQQQQMPPDRSPACNSMTSIPSLSLSFYPIASPPTLSLSATATGHGPLPASSLLFMQGGSVAVATPMSPASTHGTTGGSPTTATAPSSAYRSLVIVPWSGKSSSPSWARRAHRSLLTLFSSTPGLPSPSWPLPGQVASALSSSSTGSVGVLHKEEDRGDALSPNTSSLQFVLGTPRSFLAKEAGLVEMAAWTLSSGAAGSNAVAARDDPQPQDQLQHHSHRRLLTALHLSMRGVAAQPPVRPQAWHVWKASVAAEVRSVDKEQSVNIASPADSPVALQPLRESYEREVPRGVGEVLRTSDMGRKGDSDGGEANTLHEDKEICDADYGEKEVTAFEDKREAHRTLSRSCRSQNSIVARSPTVAAAAAVTTTAATVFPRRLLQLPSFAVLSHGKTSAAATAVAAAETEASPQTQPTSHVPLPSTSSTSFAARGEGTRGSGAAPSLVERLFVSSTSFVPPRSPSYRKTPVRAADSRSQNTCCATQLCATAPKTLFNSQTDATSHNGNNSRGGRRRGSPMRSSSRCRHTSSVTIIGVSESESLAMPVRDATSSTPGPTPAGAASWGAASASTRAAHGRETPTSSAAASPLAELLPSPPFGGIGGSVSYRLSSGCDGDIPTPDMAAAAAAAVLRLHRQRPNPTPPLSTALASSPERSAATQSLEGDGEAEGNASMLTAELSTSLPYDGNKTSRRLFHRTPSSLARAVAVALRRPSLAEDTFSGGVPLHNPSPSIPSLLISSMHPSPLTATAPATAASLGEFSAKLLQRVQEGETAEADGAAAEGGPEVLKQQRGEQEELRSGGWGVKQHNGKSPSLNATLLPFSPTAVLAAPKPPSKDKIALPTTTATASRRHCHRRRASPPNTPPATSASGTTAADADGSASEGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHL5</accession>
    <name>A0A088RHL5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_030110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009372">
        <property type="protein sequence ID" value="AIN95245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700953.1">
        <property type="nucleotide sequence ID" value="XM_010702651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHL5"/>
    <dbReference type="GeneID" id="22571877"/>
    <dbReference type="KEGG" id="lpan:LPMP_030110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_030006000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_030110"/>
    <dbReference type="eggNOG" id="KOG0531">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266138at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF56">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="210"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="280"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="402"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="501"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="561"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="610"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="443"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="229"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="501"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="578"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="616"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN95245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="863" mass="92151" checksum="9E06AE8FF1B50896" modified="2014-11-26" version="1">MLCAITAFDLSRNELQELTNLQPLRSLTRLNASYNRISLVDGLPLRLTQLNLAHNKLEHLDYVSPLVHLRELDVSFNRLTSLAGLHPRLPLEVLRADDNRIDSTNGLKELRTLRIASLSNNYVEDVDELLFVSTTPSLQLLNLVGNPVTRARRYRQALAALQPSLVSLDGAPLTRADDYENAAQTSRMSNCAVPPAAAQAPLLLVTPKMATTGPQPTLAGGSQGTAREAPAAAKPPKTHPTAMITLGSIGNDSSLRRGRCDGAAQSVAAHASIDASSIHLDDSFNTRPREQPQRLVKRSTANPTTGTLRPPAIAVSRAAPSSSLSAGAEPRHDHSVAAEPPRYPCGSPVRAEKCTKAAYGTTDDEPPVVEASCRSCRVPDASLRTPEQGSRQVGYALLHTTPATGGAANRFRSGGRPRPLPSPSSPQRNVPPQQDFDSTTAQLHDSLVAKEQLEKECQTLRRACKRVEGQLTEARRVISQQLAELSQLRLERDALRQSEGTMLERLEKEKRSGRTRASHHSDEVATLQAQYERMKTFYETQLADTRRELAAERARLLRCSNSGSSGERRVVAADSDEAAERGPRSRFSDGGRCAGAAAGSAKVELTAVASANPSGSLSPASRPTPSSPTKTGDQEPGAAAPLTDPVAQQLISWLCASLTRDQHAVEGNENLNATAVVSELRRSLPCDPSASTALANQDHQSKLQESTDVAMDGVDTRASVARRVLEMFIAQHIGQPTGPPQQIVDNNARAQSPAPAVVLVDTPPRHNVDGGAVSQACEAGESAVACLLPPRFPSPLRSSSAPPAAIISVKGDDDDDADTDTEVTVMISAPASPPPSPSSREKRVNVAKEMLKGMESLFDSGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHY4</accession>
    <name>A0A088RHY4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_040660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="AIN95390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703712.1">
        <property type="nucleotide sequence ID" value="XM_010705410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHY4"/>
    <dbReference type="GeneID" id="22572025"/>
    <dbReference type="KEGG" id="lpan:LPMP_040660"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040015300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_040660"/>
    <dbReference type="eggNOG" id="ENOG502SKB5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267013at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="891"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="495"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="564"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="910"/>
            <end position="920"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1060" mass="114361" checksum="93CE183E55212741" modified="2014-11-26" version="1">MSENVAHLLNGRPQCASGNAGSLTRHTLATDSIEEVDIVSATTRASSPEATLEQQRHVALPQKHRGLLQCASWHRRRPRSGSVPEFSLPPQQRLACAHSGRKQASEDGVFGEDTQSTGVSLSSLTVEDGNSGSSRAASADDDEERRAELSWNPRTRAHPLNSALHHDVSAKWRQCIGHRLGSATEGRRPAVSLRPPPLRTPRACARPHTHDIPATLANLLRHYLSWAPPLSPVAAATGVPFPTDGNVCTRFLSVRWGCQAMTALQSQSDLHRRPLAEERTWDAAPPCPPRPPRRAPSPSFQRRLSASHTTNRHGADEHRCCSATSCHASHRWQQEHLWNLLTHYPRDASACLSLGLGVCAALDAMRAAPPPVLPVAVLQDIAATTATEISAFVHACEEAWQTAVSASLEPTAALPSLARSMGDATCMCGCLAAGQLLDPALYRFHLLYYRHHHRYTPLRQHDGDDYRAGESSMNSTQHSGERYALEEARAAVFGRPHAQRQPPQQARCLPLPPHDEWRAPGTGPVRAPLLSATPPPPHLPRVQGTSPTALLPLLAVQTLSGFVQASSARRSSVMSRQRRRWGLRATRRGCGRQSASPPGATSTGAPPQPAPSGTQSSSRGFTTQQSQPGKSRDDDAEANPLCNYAHFCDETERLWAVMASVLLAWKQLEQCVSLVLLVPRLEVLPSSASHTWRLVPPSPTSQFSKSPALSPLARAAASMRLHNAAVEGMLLHATHDSAVTAPPVPAGGTQFERAALARLRVRLLSIPPRPRHTASAEESDNVASSLCMMEAFVYGELQGQIAHLPLWCAVAVEVLQLYIEQFRQDRTLLARMAEEEQGDAAALRAAGSDDDATWACVHSSRVHQVVLLAIRLMTLPCVFANRAFAPGVAAERTEAPPPTTCQTRRWRQSSPEDRGAKVSHECGGLQHPSRESQAAVAAATGASAANVEVPVPVSATTVAQLSAVMTRHPLFGVAVAVVGGGVPLHWAVTCVAPRAMNAHSHAAVPPPPFPAQCSSRSGDGVDSRRAHVADVAAADAEAQTELRRLVQLLHMWLREAERRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RI33</accession>
    <name>A0A088RI33_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_060580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703939.1">
        <property type="nucleotide sequence ID" value="XM_010705637.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22572264"/>
    <dbReference type="KEGG" id="lpan:LPMP_060580"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060011500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_060580"/>
    <dbReference type="eggNOG" id="ENOG502SGY9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273910at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="992"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1182"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1340"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1344"/>
            <end position="1359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1461" mass="152545" checksum="16EC519C4D21A610" modified="2014-11-26" version="1">MQEQYVRKECMAIAGQMILITAGDGTTRMSASTSHGSISVAAAARVTTAHPSATPSETKVVTGLDDLQRACDAVVRHAMTLYRLCRRPGGSAIDIVCVGAGAASAAEEAAYCVCAAVMALEPQLWASLVRRAQLLRPRKPSLLFVAPVAVPPIVVREVERFFWRSRHLMSTTAAPTVVTSGTSTAVAPRTSAASSPSARGEVGAVVPTASASSSATATATVGLRARQAEAVAACFFFKTMSAAERLRRSDVFQVHVWSPEASHAVGMSGKANTTLTTAAAAAASAVTAVGALSVEENTDVVVSSSPIKPAGAASRAQAWTAGLRRRERRPEHLVMTRGAAAPATLLGDTGHPLYTRPTQSATSLLPSFSSAASMLFTDGLDDWGGWQAAGSTRTNLLPPSSTRRSGGVDGAKYAAGVGGWSSGSSSRSRDSSPGDGDTGAGKLQGRYPAAGEGGCSRDQQAADTTAVLTRLYALALSTEDPAADELLNAEAAMQQQQQQISGGSDQHGFGGAAVSGKGSHAPFLAAASPVMLTSDSGLSLVALGASVLHACEAQHWGRLQSLVRYPLLFRAIPAPAEVSVTITRADGDEALKVEAMARMSGALGMTYTIPATILSPTSAAPSGSTAGSCDATSPSSASLFAYMSSLYGAAGSIFSPARLRTSSPPLLFPPPPSLVTDTFLWTRLLICSAWLLVYADGLVGHDDQVASLEQAQPVTDGGGHNGGVWPRVRPTPAVRAIVAYCVAVVREARGMSAGVAVTARSGHGSLRSSVCCPVCDDLVKEQRPVLWWSTLRDDRAFLRARVRAVLENNATDSDEADIAAALADHLAGEGRGRRYATPLLSGSEGTPCRIAALQQRWGAYIMRGDTSATASCAAATAATRRGAEGASVSADSVDADADLRKGGAAAADVRDPAGDDVEEEVAEAAETLWRALTQRVAAATDFCVFLSAHPTEFANSNSLAAASAKVGRPKHPRAEDDEDAASQVIHRHRWQEMHRHRQHAVGSDDSDDGRMAEEGAVESSRHHTRRRLSGVQHGNPSPRSPGSDDGEWGDGCRSRAKNTSRASAALQGSRHAVEEAEEWSRLLSRCGWVNAAPPSGSTSSSIYAEWASSLFLPSATPTPQQAATLRRRLSRYNLTDVVRKLVLGRGGGWLRYARLLFGDDVCTDYPASPHSCPPPVVHVGAASPNDLRAPPTIPPPAPSSNLRPRAPSLSLLEEAESGADGVCVPHAHASPCAKRISSPVRRVIDAGPTTPHCSSGLMPPSPLPCDATAANEDANVGSTITAERWPTTPIGKEKLPSIPLLVSPLMRRHKMAAAAADSPPPPSLAGAAAHETSAVLHCAPDGGASSAQRSDASSSASVSVPLEQLRSQQAALYALLRFRPRLPPLREEDAVLECASCFSLFHQECIAPVQLSFMGQAFLCHTCRLRWARAYAAAGCGFLHQVPERRHDARMAGGGCAPDQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIF0</accession>
    <name>A0A088RIF0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Qa-SNARE protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_070560</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009376">
        <property type="protein sequence ID" value="AIN95742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704064.1">
        <property type="nucleotide sequence ID" value="XM_010705762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIF0"/>
    <dbReference type="GeneID" id="22572391"/>
    <dbReference type="KEGG" id="lpan:LPMP_070560"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_070010800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_070560"/>
    <dbReference type="eggNOG" id="ENOG502RYQE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000131">
        <property type="entry name" value="QA-SNARE protein putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF77">
        <property type="entry name" value="T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN95742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="236" mass="27454" checksum="587BF050D1CA0020" modified="2014-11-26" version="1">MDSFQTALEELDAILAILRKRVEGVILANTLPEKKQVEMEARPIMREARQKLAALRAESRRTVDLDMRQDHDAVCKDRDQTIRNYDAEMKSQIYPRRSGTPRLKTYQEQREEEMMGDGKADGTGFTDSNQVLSAAINVQKDALQSLQRTERLQNVTEETGRTTLAELQKQTERMYHIDEELHNLRGQIDHASRDLRWFYRQLARDKCFLSLLGLCIVALLVLVFVSIWTKRMRSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RII0</accession>
    <name>A0A088RII0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_070920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009376">
        <property type="protein sequence ID" value="AIN95777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704099.1">
        <property type="nucleotide sequence ID" value="XM_010705797.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22572427"/>
    <dbReference type="KEGG" id="lpan:LPMP_070920"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_070014400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_070920"/>
    <dbReference type="eggNOG" id="ENOG502SHQ3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267770at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="588"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="691"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="775"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="929"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1149"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="471"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="691"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="798"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="929"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="968"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1008"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1149"/>
            <end position="1172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1312" mass="137713" checksum="EEB6DA24DBFCDA90" modified="2014-11-26" version="1">MTRSGEGKGTPSQQSTTVSEDFSIQPEWLNGGAGDAAFKYTAAPLAVQLPHSTTPTPLRDNDDYALDIIKESIKHQLASIAEEKCVSENTYGNLAAALRQTLQPQPQPQQHRYLSVPLQRGATSEATGACRTGGDGHMIHIPSAAVPPAPRSAAPSRPRETRAMRCTSSPVSAVGQLAATSIGQSSESRANASFTSGSGTVASGVRSKSPPQPQLPQAPSQQTAELSAEQPFKQPQPQPHSTAATVYPLNSAASRATLFEQQRQPSANDAGGMAGNVSTRGEMNIHPGSLRIPLSTSSARLMGDSRGAGEVTAVSASAEAAPRTSSHTDPSCDTSSDAATARTLTVPTTASSSSISTVLQSSCLSSERSSFKDELTSAGHHYHIHSYRQYPNQPRPGLPVAELSHGRHPHPPEIPALQVESLQEECAAPRQQERLQRKETQQQEQLQRVRASSLMSFQGGPRFPNLPPHLQPQQLPQTQRQSHPQQLLSHPQSQQLQQQQLGVPKSPSAAMMPGKIYAATPQGRLILLTPDGVRTPQVQPPQHSLPPPLPPPPLSTATSSALTGNYVTASNYSALFCRNNPLHSMRYPGSESEGAGRPACGAGRLKDEKGTAATSSSTSEGPSTQVSNATVNSVESEKYVSRSLTVGQSCDDAAANHSETRVTVTPAVVTTGNASAKAPALPTGRLGAATGASVATGSAGGVESSSSSVTASASCESRPPTSCAAPLLVHNAYSSTHGVSIGERAQHLSSHPSSNSSVNGVSGPLQLQAFLPREDISTTSPTGGAYHPNPSPGAMSALPSNGATMSPLSKVQPLRVNPDLNLGRCMANSLALSSTSPSKGSSNAQVLMPGSGYRNRRASSGTVVTGSQSVAAVGLMGSNNNTLGNLSIFGQLPTALKPLNGGLGVDITGADDSDHAAHFTHSISPPVFSASASPSSYSPPAALGSTNGNGGAVGILTQAPLQPEPASSHWSASRTDLFSQTTKSTWSGTISSPLTPGSMAPPPPQSCMHGSSPPSAQHSTAGGRLHATADDSVVVTVPIANTDGTVTAAVITVPPPFSYTDVGLQQYCLGALQQQPPQQQRPCPPLQQQHLYHRISPAEEQRTTICAGEEEEWRLQQELITLQLEQHRQRLENELRQVQFQQAQQQQQQQQLQHAQHQHQQQQLQSSPQQHQRSPLPVQAAMVAIDGRLYRMMPASSGEAFVKSGEPCRDLHSLDRDSLVSDGAAAADIRTEAPSFHLQNHPGVPMAVSPQAQLSLQQPQPQQHMFTMVSDRSALREVTAAASSLAKPPTPGANVLLVMPAPSAPHTMQYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJE4</accession>
    <name>A0A088RJE4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_090090</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the DExH box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN95925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704247.1">
        <property type="nucleotide sequence ID" value="XM_010705945.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22572579"/>
    <dbReference type="KEGG" id="lpan:LPMP_090090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090005800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_090090"/>
    <dbReference type="eggNOG" id="KOG0920">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5600252at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000819">
        <property type="entry name" value="ATP dependent RNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000526">
        <property type="entry name" value="DExH-box ATP-dependent RNA helicase DExH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000065">
        <property type="entry name" value="RNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000080">
        <property type="entry name" value="RNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059023">
        <property type="entry name" value="RNA_hel_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF145">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX57-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26026">
        <property type="entry name" value="RNA_hel_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RWD" evidence="10">
        <location>
            <begin position="133"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="382"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="645"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="9">
        <location>
            <begin position="1233"/>
            <end position="1247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIN95925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1281" mass="143068" checksum="56129A0D4B2880A7" modified="2014-11-26" version="1">MITNAGRDLIIDVLHHAATGGSVPVSEKHFDTNISSRITFQRNAPLTPSEILQRLYEGLGFPRDLVTQYLTDLAQAAEVPTFADVTELLDETGPFQAFLVHSCFELFNCMTWFLREESDDKVSPEEGDAMLEKEIDTIESLFSDNFLGRKHFDDNDTNDRELYFSFRTTYDKPLLVVVRFPDYYPTETPVIYVQPFRSSSSESLPSLVVAPSCTKDISAVDRRAVMDAAVQAINGFVSSGCLMALISAIHGVVSSLEVVRPPLSPLPPDRDAIAKERSVTREQRKAFLGVLTGSRVPNKKGTETAADEEEDHFIQFSMPERVELATVDAASVNQETQRSDFLASDAALDAVLKSSWEKLKSGSSLRKSRDSLPAHKVRETLRAALQKHNVVVIGGETGSGKTTQIPQFLYEFMCEEGNGSSANIVCTQPRRLAATSVALRVAEERDEAIGGTVGYSIRLENCVSKKTQITYCTTGIVLRRLQTDKYLGRVSHVVVDEIHERGVDTDFLLILLRDLVRRRQDLKVVLMSATMDSELFARYFDGAPIIFIEGRTFPVKVMHLEQIIPEVNYTLEEGSPFERIRGDKEMRRRNTRKNVLSLDLEDVEEDVEREKAQQKLARVVQASPKTLDTLARMNYDVINYELIESIVEYIDTALRVPGAVLVFLPGMAEIQRCLEQLKLNPRLAKSCLFYNLHSSLGSSEQQGVFCRPPAGKRKVILGTNIMETSITIDDAVYVIDTGKAKENRYNARKSLSELVTVNISKANCRQRQGRAGRVQEGFCFRLFTEAQFEAFEDHQLCEMHRVPLESLILQIYALHLGDEVEYLRKALTPPEERSIHSSVKVLTTLGALTVEKRLTSLGQHLANLPLDVRVGKMIIHGALLQCIDPVLTMAACLATRSPFIASADFRTEVENMRRAFAGETLSDQLSAWFAYNKWASALQQKGTAAARKVCEDHYLSPATLKQIESTKRQYERYLYEAGFLDNAPRSRMSTTKFIFPPFTTLDGRVFEAGGPKLNENSTSTRCILACLVAGLYPNIAQMRMTRGHRRGEGGSYGGKHTVKFSTFDGSECLVHPSSVAGKEVSFASPLLVYVDKVKTSATFLREVSMVAPLHVILFGSGKLEYLAKYEELCVDEMTAFKCRQDDATLLTHLKTQLDSALTQKINDPSKTWESISSVVVRAIVKLLKEDGGRAGGLTIIDRRQQQALLTEWLVPEAEVAASPVVPADQPFKTNKLCFLCGETGHVSRYCPHNSTHHKNGPPVRCFICGQWHFPQDCTLVKALKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJH1</accession>
    <name>A0A088RJH1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Membrane-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_100580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696780.1">
        <property type="nucleotide sequence ID" value="XM_010698478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJH1"/>
    <dbReference type="GeneID" id="22572794"/>
    <dbReference type="KEGG" id="lpan:LPMP_100580"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100012300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_100580"/>
    <dbReference type="eggNOG" id="ENOG502RZRR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271747at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001838972" description="Membrane-associated protein" evidence="2">
        <location>
            <begin position="33"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="696"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="756" mass="81444" checksum="0F871EE23FDFEF6D" modified="2014-11-26" version="1">MGRCVYRVSSAAATLLTVLIAAVTVAATTARAYDHAGVTVAGALLVGQNEEGKLGTNRILNPFALCANFDTTDVTDTALLIGGASYFFTFDRHSTYLSFWYGQGSMNLNSGPIDQVRLTGVFGCTTVRTTSSSGSPISTVYYVQNDGFLYWVMNSVVYVTLVKNGISLFDVTVYKGNLYLLSAQNSIYKCLIGPGGAVTGSACTQVMLAGSTAYANLSETSTSEFKGFAVSSAGIFIAPSSSLYWFNLAGGYIASTTTAVVFVDVKLTSNRDTANPGIPTLMAASTSAVYRVSTAGTSITYTLIAGKETATCNLALDNVDSLTDPSFCGIARIYPLSLDVVYMTTAGASVVRAIVVSNTTIRDTITRTPFPLYFLDRASTIPVLLDGMNYEIVGHSNVPFPYVAIDQSTPEVNDTTWDTSFGVDISNRFFSMASSAAVTSTPFMGSLHGLETYYNRTNQIIFGDPNVLPMCNLTKMLMIERAVATAARAALKYPYIYTSNAQNFTVNAQPNLTLVKLLMPYAFGEILNELGFFENTTTAAALAAVQFNTTMLAAVRSAYMMDRVYDCIFSGNAYPFHVLTAAQQQEVRWIIYSAIQNQLARCNQSIPYLGPDSNSSNSYNNMAPGCVPRIGINNLTEMLLPGLPYSNFNITVFIPESLYYNFGISRCLDGTDWTDVMGYLINATTRNNRKCNTGCIVGIAVASALVASFLVVAIVIMTSKRRRLATVVAPAATSEPKFISTLDMTSEEGSRNPLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJH8</accession>
    <name>A0A088RJH8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome c oxidase copper chaperone, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_030690</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COX17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009372">
        <property type="protein sequence ID" value="AIN95304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701012.1">
        <property type="nucleotide sequence ID" value="XM_010702710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJH8"/>
    <dbReference type="GeneID" id="22571935"/>
    <dbReference type="KEGG" id="lpan:LPMP_030690"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_030011500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_030690"/>
    <dbReference type="eggNOG" id="ENOG502S7AU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1915887at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007745">
        <property type="entry name" value="Cyt_c_oxidase_Cu-chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16719">
        <property type="entry name" value="CYTOCHROME C OXIDASE COPPER CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16719:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE COPPER CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05051">
        <property type="entry name" value="COX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 8" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR607745-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN95304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="81" mass="8963" checksum="9368AD2F362F219B" modified="2014-11-26" version="1">MGNRISSGSVEVAPPPQQSPKKPGCKICCACPQERRARDECILLKNMDECEAEVSAFYACLLKEGFSAEEVNALKRNTKRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJN4</accession>
    <name>A0A088RJN4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_100970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696820.1">
        <property type="nucleotide sequence ID" value="XM_010698518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJN4"/>
    <dbReference type="GeneID" id="22572834"/>
    <dbReference type="KEGG" id="lpan:LPMP_100970"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100016500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_100970"/>
    <dbReference type="eggNOG" id="ENOG502SMMF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267896at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="471"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="564"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="281"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="374"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="484"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="583" mass="64111" checksum="C800B11C99DC1951" modified="2014-11-26" version="1">MWHLPPCKSTHDITSSSLAESSSAVTPSALSEDVASLLAWGRRALQAQRQQRRVSRTSLACPDQSSVSPRPPSLWSSAASVPTPVPPGAHKHSQWLPTESLKASASTSDVLLTAVDTVHTVEQARKRLAQLEELAAANTRVFESRWALLSLGRERLLRLHGEQREVEAPSPRTREFQRLTVTAQAIVEGEASLKEILRGIHQGLAVLYQQHHNHHVEGANYPSSTRHQRNALVESNYVGSSCNSEEGAEVEEGASDSLRSLADAVVRRTRLVVNAHLQWQRARAEQQRAAAARLQQRTESERALRQQLERLKAALAEATEQETHERRRLAELRAQCAAAERAAALQYASALREEAAKEALQRLQQLQQHVTLQNDIARQELAASETRYDQAKVAYDVAISDHRAAEEALAAAQQACRDSKRRREDAESGLVQVRQALKSISDKCDALRAQRAQAAEDCTLVDEAFNQKRRARDGLLTGEKSEDSSGTPTTLPLSGSSTADSAAERYAVLQRELPRLEEHLQHIVEEVSALERTEAGLRDTLGRVMGALGLLRRQKTALEAYLASPDNGVDDATSRCGTGDGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJS6</accession>
    <name>A0A088RJS6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhodanese-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_091460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN96060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704382.1">
        <property type="nucleotide sequence ID" value="XM_010706080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJS6"/>
    <dbReference type="GeneID" id="22572716"/>
    <dbReference type="KEGG" id="lpan:LPMP_091460"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090020100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_091460"/>
    <dbReference type="eggNOG" id="KOG1530">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="566238at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE RDL2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086:SF10">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE_RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="30"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="150" mass="16213" checksum="E438C41DE4A7AA18" modified="2014-11-26" version="1">MLRGTRYLCRYFTIDQVANIVKAKQSCSDAVRNIQLIDVRSTAEVAATGMIPSAINVPLPVLSDALSPESIIEDDEFEFFFGGPRPVQGVTQLVLYCAHGVRSAIACELAEELGFENAGNFSGSWAQWYHAYGTPSTSAAPPESSPTPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RK74</accession>
    <name>A0A088RK74_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">type I protein arginine methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.319</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_120950</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48096"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11991"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61897"/>
            <dbReference type="EC" id="2.1.1.319"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:48097"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11990"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65280"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:48101"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="2"/>
    <dbReference type="EMBL" id="CP009381">
        <property type="protein sequence ID" value="AIN96422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697075.1">
        <property type="nucleotide sequence ID" value="XM_010698773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RK74"/>
    <dbReference type="GeneID" id="22573101"/>
    <dbReference type="KEGG" id="lpan:LPMP_120950"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_120014500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_120950"/>
    <dbReference type="eggNOG" id="KOG1499">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035241">
        <property type="term" value="F:protein-arginine omega-N monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000001">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000034">
        <property type="entry name" value="Protein arginine N-methyltransferase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF53">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06325">
        <property type="entry name" value="PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="11">
        <location>
            <begin position="193"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN96422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="369" mass="42193" checksum="DA23AC299BD8F294" modified="2014-11-26" version="1">MRTSNFFHRCCLLATNKPRASRAFHMSSPTQCEKAAAEGAVTTKTTANKDYYFDSYSHYGIHMEMLKDYHRTTTYRDAIWRNAYMFKDKVVLDVGCGTGILSMFAARAGARKVIGIDCSNVAVQARQIVQDNGFSDIITIIQGKVEELDLDEKVDIIISEWMGYFLLYESMLNTVLYARDRWGASDVKILPSSANMYACGITDPQYVEQKFDIWNNVNGLDFSYFKRLSYIEPLIDTVNPEQIITDIVPFFSFDINRVTEAELSFTSTFTLEAKQGDFVHAISVHFDTPFYAGHDPVVLNTSPMVPPTHWRQTVLYMFHPLIMKRGEKANFTMKCAPNPGNPRDLDISLHIDFDGELQACHYDQDFRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RK86</accession>
    <name>A0A088RK86_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell cycle sequence binding phosphoprotein (RBP45), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_110140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696863.1">
        <property type="nucleotide sequence ID" value="XM_010698561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RK86"/>
    <dbReference type="GeneID" id="22572879"/>
    <dbReference type="KEGG" id="lpan:LPMP_110140"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190006700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_110140"/>
    <dbReference type="eggNOG" id="KOG4679">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="243127at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047767">
        <property type="entry name" value="PSP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041131">
        <property type="entry name" value="RicT_YaaT_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830:SF3">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="2">
        <location>
            <begin position="203"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="292" mass="33185" checksum="D5D29FEE367CABDA" modified="2014-11-26" version="1">MMNTTLLVQDVDEIQSAVDRWYCQSSSNLQESHAAFLAQLRQLQEHLGLDAGAPALSVHADAMITPPRHMYPSDDNNSGSPPMASPPISRGQLNYDHLLDEVVSKNVAMSPFNPEEEAERRRRPNAESVRTPSTPPEDYNGPCQVLVEFKRKRMLQYESPYYVAPGEHVVVGGDRGEDIGLVTHTWKGAEAHQLGENRDKGVGKVLRVASVLEVTQLQGVQTELETRAVEVAQEKVQENGLPMRIVDAEYQFDRRKLTFYYQSMHRLDFRTLVRDLYKTFRARIWMEPDTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKX2</accession>
    <name>A0A088RKX2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MPK7</name>
        <name evidence="10" type="ORF">LPMP_131510</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697231.1">
        <property type="nucleotide sequence ID" value="XM_010698929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKX2"/>
    <dbReference type="GeneID" id="22573261"/>
    <dbReference type="KEGG" id="lpan:LPMP_131510"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130019800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_131510"/>
    <dbReference type="eggNOG" id="KOG0660">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277790at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000405">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="62"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN96578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="593" mass="66348" checksum="41597D53CA890ACC" modified="2014-11-26" version="1">MDGILSGLNITCNEAALSLIEMARSNGLLFSSSDLTATSDHTTEHSHHYHVCGSSFDVAPHFEVLNAIGHGTYGLVCAAVDLRLVPSSVYYNEAMRTIEEEGRIVTRRRRGHDAPIYFRTRVVLGETPSGSPVRVPHLYSEPFKRRVLAHGEVSPFVAIKKVAKVFDDLVDGRRILREVKLLKYLQGHPNILRLMEVGRPPVSTVAPSSATFEDIYIVTDLMDTDLAALLKSSQEIQMNQLRFIAYQLFKALVYVHSSGVIHRDLKPCNILLNGNCDMKLCDFGLSRGGVPAWLHESTLKAVAADAESSIEELEDWGRFCWSSSAARSASCASHVAKQPPLYSLTDYVVTRYYRAPELLVMGRYNHAIDMWSAGCILAEMLLRRPLFAGANYLSQLTLILETPGLRDVPQAPEQVATLFEGGEEGKHFICDILFHNTAGRWEPRTLRNQVQSQAMFHTTLFGSSADIPVSLGILIAKLLSFDPRKRPTAVEALRDPFFRPLYDARDEIVRCTASDSGFAREEIDDIAAYRKTHPCVVVDENPVFPWEFDHCITNAQTLRSLFEEECQISRDVQRQIERQQRPLSTPTACSLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKX6</accession>
    <name>A0A088RKX6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_130610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697143.1">
        <property type="nucleotide sequence ID" value="XM_010698841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKX6"/>
    <dbReference type="GeneID" id="22573171"/>
    <dbReference type="KEGG" id="lpan:LPMP_130610"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130010300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_130610"/>
    <dbReference type="eggNOG" id="KOG1196">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9992527at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08250">
        <property type="entry name" value="Mgc45594_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051397">
        <property type="entry name" value="Zn-ADH-like_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF3">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="21"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="345" mass="37284" checksum="A261124977442BCB" modified="2014-11-26" version="1">MQAMATAARTYRHIVARELSTDFRAITSIVEAPFPRELHPKAILVKNKYLGINASDINFTAGIYQPEVRPPFACGFEAVGEVVDVGSGVKDLKAGVAVVTQSYGAFAEYQVVARRHAKPIPCLAREYLPLDLSATTASIALEHVLKPQPGERAVVTAAAGGTGQFAVQLLKHVYGCSVVGTCSSPSKEVFLTDTLKCDAVVNYRAEGNNTAAAFMQCYPRGITIAYESVGGDLLEAVIQSLTLRGRIVSLGCVSTYQNGSVEAVRPSHKPLPLQLLAKSASLSTFFLPHFAKYGQQHFDRLCALHERGVVQSCIDPTTFKGLEGVYDAIDWMWGQKNCGKVMVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RL69</accession>
    <name>A0A088RL69_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_150440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697420.1">
        <property type="nucleotide sequence ID" value="XM_010699118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RL69"/>
    <dbReference type="GeneID" id="22573460"/>
    <dbReference type="KEGG" id="lpan:LPMP_150440"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150009500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_150440"/>
    <dbReference type="eggNOG" id="ENOG502R2GR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001410">
        <property type="entry name" value="Hypothetical_protein_-_conserved"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="696" mass="78005" checksum="5001CD1F6EFEA0E1" modified="2014-11-26" version="1">MLRRSRVALAPSIPRSVWDPAQHNDHWVDSYSTSIADRRHWPAKKWSIGLEPRTPRDWLRFSYRNLAYAYNGALRACATFPEMLIYYKEMKQRGVKVDMDTLNAVLSRAARYEHIQVDDVFLLFDELTALGARPDIASVETLHTVLEHAAHQPPEWRETRRRQLVELYQHLALEEIERLAPYHVDALLSAQIARLRGNLKQLSASLSPSVYRRYFAVIDLGETLIQEVHNFLWEYVGADHAAMDVPSLQLRIPFVASVMKRPPATADPTQVKATDFEDTDVCSVLLAAVERCVDGNFHDNRPVSERRMYLALLTMLTSSGVLYSADLIAQMMDIVKYSRDDRGRDRDAQRLLRYALRGSSASNDAAYRELWRAVAPAVDARVVGRYLASRDPWSPVHICFDRSFQFRAFPPLQLSAKNSSSSNSTASPAAVAASTAAEADSSSTAASVAERKEAFEGEGIDVLPRTVTTKTAEALQQRWDDVRRLIDVTDVLKQAGGLATTTAGTKAPTQEMAQQAMEVFTGAAAFLRGVATGCRYGELEDALAIQAVGDGQHQQQHHTSRAVSRGGTAVPADAAHNSSGKASAMLFASDLNFDVWQRLLQCVQQLLQDMEQFMAQQYEVHGLQVEPEFECWEAMLVVLRCILDFCLVHTQQYGRAAGGGMAENLFQESAQLRAQLVEESRTRFNSRMRILWLQEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RL76</accession>
    <name>A0A088RL76_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleotide cyclase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_090330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN95949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704271.1">
        <property type="nucleotide sequence ID" value="XM_010705969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RL76"/>
    <dbReference type="GeneID" id="22572603"/>
    <dbReference type="KEGG" id="lpan:LPMP_090330"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090008300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_090330"/>
    <dbReference type="eggNOG" id="ENOG502QQZF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272956at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006189">
        <property type="entry name" value="CHASE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50839">
        <property type="entry name" value="CHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="CHASE" evidence="3">
        <location>
            <begin position="147"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="761"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="809"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="770"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN95949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1030" mass="111613" checksum="893E07B397734FC3" modified="2014-11-26" version="1">MKKIYHIPTGNSAEDEQNNKRQAKRYRVYFIILAVLVALLLMLTTILTPMLLLQHHDNQLEQRHRDEERLAAKDYATTFRDAILGAISAVYGVEGYIMGVMKTLPNLNDTPAQRVEGQYFPQFYRYAELVASAAPHISLFATAPGGVILQVYPLKEESPLKGWDLLNSSGSGTNHTDPAEGQRQDPYTVISTGMLDLTGPYKSSILPTIDGEKSYDEVNMWWVDLRQPIYNATSTALISNSTFWGFGIVIFSVDGLMQRYNFTKAMDINEMAYIVYTMDNASSGSCTVIIASPIFNGETDCNTPNMQKFIKEATTRDVLSEKISWRISLKSTKRVNQFTPKVRNIIIISSIIGVFALFALCVCMIVRCTRVYDGTKHAPKMAPFAMLTIGPCRGEELWDLASDQMVEVTERLGHVLAQQMVRHGAYQIQQVHPLTTSYVMRSVAAAVQMAFSTIEELYSCPIDDPLRRLLGDEGRLLLSYAVHWCTDAAVRLEVMGNGLRYEGPDVVYSGRMWVFAGPNVVTVSPAALPSAKRMPHVKCKLFDSVFLRGVTTRQDLYVVTDTSNHHLKEAEAFAAEQVRRARQAQLQYTAGKETEPGSTLYTPQGRLFTYPGIGYENSDLDNDSLCLARTAADGASAASGNRISSHPIPFANSTGGSHVAAGGIRKGARKDGGVGSCSVPASTPDGVLAGTGENGSESPSALSFVVPQRRMVRRPARKNKLSNVVLGSPTSSSNVANVQTGNAVEMAAVNPQTPLLQHNATLSSSASTSGTNDISGNHSRSAIGAANNAQHPDVLPTNPLVVVPPSTTMVAAAHGPGGGSGGSSSSTSSRNCESSVWRPGNIPPFVGDNPLAGSNTGPGPTGGRGAVSSLSVCGTSHNSDGSAALQDNASVLDNFSSDLLLRPAISSQSDLLLRAVFDRQAVALDLSYDSVRVLVYYFYSSYKILFRPLAAPELHNIYRRLVTAFGVPQQGILEHLAARCATRFLQRHEETQTRLWDQQHRLQAHIRSVSASTAVATSSVSDDEAANISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLL9</accession>
    <name>A0A088RLL9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_160830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN96957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697610.1">
        <property type="nucleotide sequence ID" value="XM_010699308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLL9"/>
    <dbReference type="GeneID" id="22573661"/>
    <dbReference type="KEGG" id="lpan:LPMP_160830"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160012500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_160830"/>
    <dbReference type="eggNOG" id="ENOG502SJJ6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273385at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="224" mass="23903" checksum="3BB18C4D301AA5EA" modified="2014-11-26" version="1">MPVIDTPFVMELHPGEELKLAQAPSTPLSSSSSVAFSHSTNALAKNQFHALVSGVAFVEEDANDSGAATAAATVFKPHHKHSVIRVTLLAHMQPQPQGSPTKHFMRTVTLASCNFSSNPSPNGDAGNVASLSRRGKTGESTLSLPSTATRVESTVQFRSPLLFHSSGSIQSLSVVAEDMVATVGSSDSRGSVKRYKGSRRFGVRLHGIQHTFLTKEQVLLLTQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RM40</accession>
    <name>A0A088RM40_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha-ketoglutarate-dependent dioxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_160360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN96910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697563.1">
        <property type="nucleotide sequence ID" value="XM_010699261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RM40"/>
    <dbReference type="GeneID" id="22573613"/>
    <dbReference type="KEGG" id="lpan:LPMP_160360"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160007800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_160360"/>
    <dbReference type="eggNOG" id="KOG2731">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6614653at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035516">
        <property type="term" value="F:broad specificity oxidative DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035515">
        <property type="term" value="F:oxidative RNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035513">
        <property type="term" value="P:oxidative RNA demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004574">
        <property type="entry name" value="Alkb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16557">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16557:SF2">
        <property type="entry name" value="NUCLEIC ACID DIOXYGENASE ALKBH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="193"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604574-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN96910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="367" mass="41840" checksum="AD7D20E444115B22" modified="2014-11-26" version="1">MAEKRYKLYELSRRDARRRPPLPETDLTDVVQLHELDRNTEENRRLIHRVVLPPRSQHNANTSLSAADKIHHDSDVVCYTFAGVPGLLLFPGVLSEAEQQRWCREAVLDYGDSEHHPNILSTHARAPQSTSCYQPPMRWATLGYSYEWTQKVYHRDRYSTFPSALRQRMCDLVSLVAEVRQDGFCCAYPDTYEPQTAIVNYYPVGSMMMCHQDVSEETLEQPLMSLSLGCSAVFLMGTQSREDAPHAFLLRSGDVAAFTGPSRAAFHSTPRILDDCPAYLTVPEDELTDAERSRYHHHAYCARPMPNGGFSRVDKASMTAEEQERYWRLCMRHMRVNINARQVYNVQCPFLFDAPHAMACGADTGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RM77</accession>
    <name>A0A088RM77_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_161530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN97028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697681.1">
        <property type="nucleotide sequence ID" value="XM_010699379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RM77"/>
    <dbReference type="GeneID" id="22573732"/>
    <dbReference type="KEGG" id="lpan:LPMP_161530"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160020700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_161530"/>
    <dbReference type="eggNOG" id="ENOG502QUUZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275382at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="668"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="692" mass="76817" checksum="C79C2812A1D2DC32" modified="2014-11-26" version="1">MFFSTGLPRCFASLAVASASRFMQAHLTTETELHPGDRPALWIDDTAPATKTLKEHVQSAAYKELHRPALTTSAMGLFGGEPGFEKAHRVWVDPDRPHMKHVYNQTPLAKNLRYTRYGYFKRDMHLLDIDKLVRHARLLPTPNRLLTDFLYQRVPLPDKSCAAILRYQRDQLTLVADWQRVASFQCAEEIFERMVVTNIPPVDVGPETHAEMIRCCAVCGEWEKGWNVYLQRAREMEVAAAGDTADAFTLTTYLYDAVLELCVACQKPSHGLAIIAEVIQRHLRPRPSMLSKTMTLVSMAAEELQRTFPTSSAFASGETAEAGSNSSSASPEALSEVSEVPATWEAYTAHGLDTWSLYDFYSLKRSSECVEAYMRMCSMLNMPTLVLEALSFADGAQIRVSLECYQWALYSIRHVPGMGDYIIDVFAQLSQRGLTADYLLFTTAFLVCATQADGELALAVYEQFYVHSDINPTPEMTLLFIQACTTCDTPTIQMYAGCEAMVQRLEGVGSIVDNILPIYDQCIELAAHVGAVSSAYSRVKKLVSYGKPLTTRILNSLLLANAQSTEGSLSMTFDVTRLYSLLGIPFNDDTLTCLRMCQDAHGTSAEVDSFAAAIEAAQAAALSGTLGEDAETEIVDTPPHLLRQLKTVWHLRPRDTMLRRFGQHMKPRGREDVGSMLGSTIPFGRSPGERAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMP7</accession>
    <name>A0A088RMP7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_171100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697801.1">
        <property type="nucleotide sequence ID" value="XM_010699499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMP7"/>
    <dbReference type="GeneID" id="22573853"/>
    <dbReference type="KEGG" id="lpan:LPMP_171100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170017300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_171100"/>
    <dbReference type="eggNOG" id="KOG2198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="427002at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808:SF7">
        <property type="entry name" value="SAM-DEPENDENT MTASE RSMB_NOP-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="7">
        <location>
            <begin position="306"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="615"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="434"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="587"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="501"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="534"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN97148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1173" mass="124827" checksum="8C82AE38D2257EE2" modified="2014-11-26" version="1">MLRPTRRAVFDSFRAARGELDPLFSMKSEQLMCKAVRQYIVPSLSRQRHRSIGERLGHSQERSLFRTNVSLLLQEARRRGDYRVAAAALDVALAETELSRFAKLFEPTWIKDAVSSCRSAEELRVVEGVLRQHEQRLLASGSAPASEGFLLTAAFGRSRATERALRCGDDDADADDGAQSGALASTISASLQTKGDALGSNDAVENSVVGATLSEEARVAAALVQPPSLTDLATTGGTGSDALWLSPEERAAAGLRRLQRLQRNLTAGPNVSFTRYFLRQGLVRHEGELMALYQAMRARPLDVSFRVVGGGDAATDDAQPSGLLSPHASAVHCLLQRRRGLHRVPWLPPAMGAYTLDTRESTPADTVLANRQLLRSLARERLIVFQSLPSMLPVYYLDPQPGECVLDMCASPGNKTALILDCMHAGGNSEAHLSSSTAAGPSAAASESGRRRPLVGSGCVVANEAQASRIGDLLERLRNASPEVVVTRGRGQTFGLVDSHDGSSTGSVGGRGDAASLGHEAILGEGLYDRVLVDAPCSGEGRMGRDALSWRLWHPGRGIEFFRLQCALLQRAVRLCRTGGRVVYATCTLNPLENEAVVAAVLRACGDAVALISPPRPLPRRTQSQSEEDDGGSVPPLHLTAGLRSWDVPSGTGGFLCSATEAYAQGESATRLPPEIFAPASTGAEGDPKDIGGALQRCCRRVMPHLNGNTDGFFVAVLEKRAGVPPMLGATESRPLLAPSSYLDTASTTAVVPTLTAAASLAVSLAGGSNILNDRGFVRLAPSHHLVVKHLGGFFTSAPSHPPTASSAASTFTTQEPQQRECVSAQDFLERHGWTAFWCEGEGLRLLTRSTVQLLRRHSTIPVIPPTRKPNLLGLGFARPPQNPSDAPPAPPSTGTGLLDAGVLVVTAQGALTERGAALIRPSARSRVVSLPLFFAQLLLANRTLDIGASLQAMPTHIQEAEQALGPHNGVLTPFSAATQDRDDAGSGEAHTSTWYREALAALTPALGEGVGVAGNAIVVVRFSSSGFLAPPSWATPLAQWAWPVRVEVIKPWSSHNIGDTPRGLARLHLMLPAAARHRTQALIGRLQGHAHRHRNQQERLQASSRHDPSLIMGQQELHGSALKASQQHRLLFGAAAQVSALRAQPNAAPRALDSKITTPGTSLSQSLGVFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RN12</accession>
    <name>A0A088RN12_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline transporter-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_140380</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Choline transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697272.1">
        <property type="nucleotide sequence ID" value="XM_010698970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RN12"/>
    <dbReference type="GeneID" id="22573305"/>
    <dbReference type="KEGG" id="lpan:LPMP_140380"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140008900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_140380"/>
    <dbReference type="eggNOG" id="KOG1362">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="44736at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF4">
        <property type="entry name" value="PROTEIN PNS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="465"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="508"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="535"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="43"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN96619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="607" mass="65351" checksum="D8BC537466F7A2C8" modified="2014-11-26" version="1">MPYTAARRVGEKAPLVSGNFSEMHRDPYLEELGPGVPVYSASAIKDDRTSRTSGTTSTVGCDSSEDDDSSWDTEKPKLGNNHDGKQQTQCTFYTPGGRPSNNELWRFRARGCQDCWAALFLAALVAVVLLWGMEQVWQLQLTERDLAVIGGIAEWGGYAKVSADADATGTSVQGKVLRRTAALRAGVAALWARMGGLVPPAEAYNSDPSPSSSYADMTGSIMRVLIWCAAAAATTILAAYGGLLLIAVYPRQLIFIQSAVASMLSVVSAGVALAQGALLTAMLFGLTSLMPLLWIYLIQDRIPFTATMLCATVSLLRRHRSLFIISLSSAIASWCFVVTAVVCVLPSVLRLLAGTAAGKDTVYSIVVVFSVFWVQEVLGALVHVTVCGVVATWYFAGEGRIPSFPVWCAFQRATTTSFGSVCLGSLITAIASFIRFLIDTARSSNDGDSFCMCIMSSLVGCIEDLVRYFNLYAFVHVAVYGCSYVDAAKETWRLVKQCAFSAIFNDSLTGQVIGILTFMSALLVAFLTWLVTWNAGAVTLMFFMSLAVSSIFYNPVSSCVTTLFVCFAEVPVGLQLSFPELYAALVSADAGYTQRRGKTNMYGTALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RN46</accession>
    <name>A0A088RN46_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Guanine nucleotide-binding protein-like 3 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_190210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698016.1">
        <property type="nucleotide sequence ID" value="XM_010699714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RN46"/>
    <dbReference type="GeneID" id="22574075"/>
    <dbReference type="KEGG" id="lpan:LPMP_190210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190010500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_190210"/>
    <dbReference type="eggNOG" id="ENOG502QWTI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="244362at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="625"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="659"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="672" mass="72966" checksum="B5BC3B1AE595ABEB" modified="2014-11-26" version="1">MVKVKASKSKRMSSKQRHKIDRKKIEHKRDLKKAAKALKKSGIAPKRSKKSHDLAKLALKVSNRHPDKEQILSHVLQARETARVMKAERRAHKSIEAEADGGEGDQPVNVGACARNRRQLLYISATDSNHFCVQFNRALTELVFPAAAAAEDAADALILELPAVAYVVTLDARFAAQSMPWTLLDAIIDQAADYMGGRRVLLLFTLTKVDMVSAPAMVSQLALVAFALQQRYPQGLGDNIVSTITPFSVHSERTQRQFLRVLNQFRQSEGCSSKRMASNLTGKICAFVIGLPNTGRRTLCRTLSREANESSVSTVPLRAAQLQLIRSGLTEEEEKVHRKFAMPNAKAVTLVQLPEDAGMIKELRTPVGSDVLFRSVAFVERAPEPEAMGCVLFDGVADKAAMAQAFCVPAVGGAEGSERNLLKEAGKFLRELGRAVRRDGGFHVSPLFASDASTMGKVTSSSLTAHGGFNSGQQRSQSTLLDVTYSNATPSKLVYISTVMKKGKGKSSKYQKVSRADAHNALRLGARTFLREMSEGRHVPWAVMRASGDVTLTPAQVGAASEIFSLAAAEGKRLAETDELKGTDHLNALVDVLASAVRDIAVLLPNGVVEMSPDFLTPPQYKLEKDEAAAVEAEGDDREEAAGEQGGSYSEESHNEAVEGSEEIDMDDDEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNA1</accession>
    <name>A0A088RNA1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_141060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697337.1">
        <property type="nucleotide sequence ID" value="XM_010699035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNA1"/>
    <dbReference type="GeneID" id="22573373"/>
    <dbReference type="KEGG" id="lpan:LPMP_141060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140015800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_141060"/>
    <dbReference type="eggNOG" id="ENOG502SG8Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="262308at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="416" mass="46196" checksum="1A0186588A3600AC" modified="2014-11-26" version="1">MGALVPLTQAPFQVCVRSPRILQRRVCRRWEWLTPLPLLLPLLLAVVVLLSSLSDASISSCLCRSNTRGQRLCRDAHLMLSSRALFYNSSEMDRRVARPRASSVPGVLMAHAAAADSTTGDGDELASDADTWGTISMKRTLDYDSGLKPFMTPWREVRLALRDAGCFSTLALPRLTLPTDTAGPRLSDVAPESSPTLPPLCRKPLVLMSGRAQDCPSCSSFVSDVLEHYRAEWEYIRAHVTLVDAGDPMTDELVRNPYPLWYNLTEVGQLLTLTKMSEVRKAEDDVAAASSGESSASRASPHDVSQGLQQSEADDFTVFNTGLRHKAALLLQSPTVQATHQWSRLVKRAFAGQSEYVLRIIFVYPHNASVMRDVVNEEVTVDGSQADYLHFFSKAKPFFHCVKKAVRVMEWLLRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNK4</accession>
    <name>A0A088RNK4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_200310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698230.1">
        <property type="nucleotide sequence ID" value="XM_010699928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNK4"/>
    <dbReference type="GeneID" id="22574238"/>
    <dbReference type="KEGG" id="lpan:LPMP_200310"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000054300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_200310"/>
    <dbReference type="eggNOG" id="ENOG502RXBS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271962at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="436"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1014"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1014"/>
            <end position="1023"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1050" mass="115073" checksum="CB3FB352B35E89BA" modified="2014-11-26" version="1">MHVEIRLCEVEHACAFDPQSFYRVKQLLSSYSGQSNAAEEPARRTWHGGSLLRLQHTAPFTPELKLQVVVERLTEMESKCFGATMDKKQHEARVKSHWNNSAVGTAYYSAEVKEVVLASLPPAAAHSVVKIRLLQLPPQLDYNAQQVVKRAIGDMAVSRDRHDTPLCIGIAKICLRELMLARKTVRIAMQAKRAVVSAVEAHNLDTLITNAMFGRGERNGSAVLSVQFNGYTFGRVPRGGPIPNHSPVGATKRITTAMDSNEPSTALPLVSNGAAGESAAEMESEALNSRAIHFVLLPYVALVDVLLRMVDVASWRVPRKTGMALTAIAIALYADLFDMLFVLTLALVLLSVLRNISLFYYVPVSDHTASRVTAPSVVGSGTTNFQPFLYSRENALLNSLLRARVFFSRGLMDDTYYELALAAHLARHNRRQLAGLGLAVCCGFAFLSMGAVVSFLTLGAFTAYPVFLNLSNARRRTRRKKVSLLVLIRYAVDAIHVPRRYPVVRVIRVAVVRARTEKSPSRNESIVDPVAETLQQQFLNCIRQRAESVEARSPTEKSELSMKTRESNIPAVYRQVRTMDLDVLPNNSANFASTLNRFQVTHVMRYFVALCFSSSVIESAELASTTSGLRKPPSNAALQRRLCDQLRQARIISGMLPSVLPQSNNIATGGGVTTFTQHSGSVTGDSKPAVVSKEMQEAFQNYFNSTLTLLFYLRQQWTFHPYVTQSSTTKCMPDSMRSVSVLAQPQDLIDAGEDDGVTKALMARRQAPHNSPLVGRFSSGNPVEVSGRIMALYAAYLLQGARLSVYMSSNGCATFLPLLAPGNCMERFLQPNPCPADLLNTLDSVWRGETHDTMKKGKEVYFNADAVLQIITVYKNYWEGGANFTSTRSAVRLDSTVAGESYFSNALHRSSARSALVSLPPIPRQQIMPYSASTHLTRSLQDSTTPQTKFGTAAAGSAELLPARFFSSAATELNMENVVSQASAASSDLYPFSNGALSDPPVLDATYSRDARGQLLVKDERARNSVPDGNGARTASGKGNAAETLFKSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNP1</accession>
    <name>A0A088RNP1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_191240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698118.1">
        <property type="nucleotide sequence ID" value="XM_010699816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNP1"/>
    <dbReference type="GeneID" id="22574178"/>
    <dbReference type="KEGG" id="lpan:LPMP_191240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_191240"/>
    <dbReference type="eggNOG" id="ENOG502SRZ2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272787at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38827:SF1">
        <property type="entry name" value="T. BRUCEI SPP.-SPECIFIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38827">
        <property type="entry name" value="T. BRUCEI SPP.-SPECIFIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="120" mass="13118" checksum="33919BC7C9003E47" modified="2014-11-26" version="1">MFGRRVFASAPLPRYMWTKMHIQNAAQAGRMLPSFAPLVSSLSRSTNVLNSQALTQARDGMASVSGAASTDDLLSLRCFSGSLMTVNPIVFGAVRFSILVNMPLVSFLEFCKDEEMKHVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RP25</accession>
    <name>A0A088RP25_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_203520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698554.1">
        <property type="nucleotide sequence ID" value="XM_010700252.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22574563"/>
    <dbReference type="KEGG" id="lpan:LPMP_203520"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200041500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_203520"/>
    <dbReference type="eggNOG" id="KOG1912">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1291858at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039694">
        <property type="entry name" value="WDR11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14593">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14593:SF5">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="950"/>
            <end position="976"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1307" mass="140378" checksum="3C66314EEB83A6FB" modified="2014-11-26" version="1">MNIVSAAPPLSSKVIPGCSNTHSNSGLPTILSDLGTFAYQSASYGPQQLLACSSAVTNAGEVIFVYDMNSMLLIQSLSGHRAAVTALLWRRPPVSYLQTGLFLWSGDASGALMYWDVGEGVALTSIQTPCHGLVQSLTLLTDDHLLVATQEGSGYVYNSHLIDNTSLPPGSFPLEVKQSTLLGSTSRPSIVAFSRLSDQHSCAVVLGDRLRIFKSIQLESGAAPPVAKDLIYDSSDGAATVIDAIFSDAQEELLYFATRNTVGCYDWKLEVMLNESFLWMPGEVEFRRIFRSCASGVAARVGSCNQESIASSASDAAAAAQVPIMYSFGSDQRLAAWHTTRHNRFTSVAMDVRGVRINAKRCFNVAQSELDSSRFAVLFEDGAIAHWQYISRTRRWKLLDCWLAPLVRPVAFCPVGVYHCCVALESGHFILMDITHSMAVRRFNLVYSGGTQIVLLCGYKWSDLVWVVSDRVQQYRHHHQVSLIDTRTGEVVRVLRKPSSVPEQTRMKEITMDTTTTYVLLTYWNGTFEVWTAADSRLVHIHAGLGVANVSWAPPSMRRCLSGVQGTPQLLAVLFSEGTLSLWSVYKDRVVVSRDAISLFHPSVVEGSVRSAVVGDTLVTWDSHGNGVVLRAQGTRLAVRRLRDAPPNSGAAMCLGGLPPPFRATSAAEFMSFSSPLAWTTSGSFAHDGDDDNGADSTGTDAVGSFSPPTTDFSAARAVAVLFESGVFAIWDIATGECRALSSAGMAADVRALSLYWAGGSLCVLGADGCLYVLDMTLTEMNSSVRYRALRRPMKNVAFLLPAHRTYVQVALELGTPQSAVGDGAQPASHSLGAPPSAVMEAVSASARPCRGPFGQLLTEDIRTLQDELELYRTTMVPRYVLLQLSLCGSAAVTTAPASPLVWLRRAAVVAGFFGQPTKQRFMQLAADALCHWSPSAVVRREVGCRPLGTSSPADTTLAAESADQPPASSESESLNAASSSVPQTYACADAYSEALAPPHVVRRNRILLNEQRTAALLSNTHNHRARDDCVTRLALARDWLRLEHRQHAIEVLLDASPQSTRYNELATLSMSVAASTAVKSSSVDSASSALFAASAKRAAAMLLAQGDIEAAVEKLVLAGEYRSACVTLQSRGRWRDAVLLVKGVPQMQRPLLGEVLQRWSALSVQRGYRLLSAALLLACGGATTNETPPPPLAALSLLMESAHFTDVAGVLALVLAQYYEVISEWPETAAAMSSSISLAHSLGIPPAQPVSASAMMDNVLHALGDYSSLLHTIGNLAGEEVVLRQAAALKASIRLTVKDNTDEGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPK3</accession>
    <name>A0A088RPK3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_202490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698452.1">
        <property type="nucleotide sequence ID" value="XM_010700150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPK3"/>
    <dbReference type="GeneID" id="22574458"/>
    <dbReference type="KEGG" id="lpan:LPMP_202490"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200030200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_202490"/>
    <dbReference type="eggNOG" id="KOG0371">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0374">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271734at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF514">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="3">
        <location>
            <begin position="218"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="573"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="574"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN97745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="628" mass="68300" checksum="43A88CEBF1B409F8" modified="2014-11-26" version="1">MSALDSDAVCYYLYDPKLVPPARNKYIRVVSELLAGYYDSSYVDNVNIMDILRGGTMEVVELCEDAKCVLSKEPTVLDLRVSEEDEFVFVGDIHGQFNDLLHSVLSVQLAKSAPVPPKCTNVATQPTQCIDDRKGNCEVDPPLFVASAPTLSSSSASLSSSTAALCRRDDSNDFGTDAGKIVRFLFLGDYVDRGPRAVEVIVLLLALKIEYPKHVFLLRGNHEEAQTNRLYGFFNECRAKFLMVPRTCAPMPDVKSKYVDVCASLIQRSPKNAAKENAGVEYHSSHEHLLHLGGMCTSQLAFDSASSRGNSSNTEAKSSLTDPDVDAWMSFNATFRWLPLVAVVRCCAGLFFCTHGGLSPTLRRITQLDRLKRETYGTGLCETITPQLLLSCGVTGSPERSPPGAYGSPTSKREANQIIDGLLWSDPSDHEAGCQVNVRGCGYSFGADVTRRFLDSNSGYAPSQPLLLQLEVNQEDEEEWGSCPGATPPGKDQHGESQRMHFIMRAHQCVKAGFQWNQEGLVVTLFSAPNYCGMNGNKGAIAILRGEAQAPGTSIQLGFKVYDTYKSPLPIGGSQVTLSKSEQTKSGSNPSAAGGTPSRCPALPLRDRNIVNNPILEAYFGSITTPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPP7</accession>
    <name>A0A088RPP7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_204450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698645.1">
        <property type="nucleotide sequence ID" value="XM_010700343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPP7"/>
    <dbReference type="GeneID" id="22574656"/>
    <dbReference type="KEGG" id="lpan:LPMP_204450"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200051200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_204450"/>
    <dbReference type="eggNOG" id="ENOG502S0XD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271730at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="149" mass="17203" checksum="4DDEE4FB38595E7F" modified="2014-11-26" version="1">MRQSPASLYVDSMHSNTLTDHPLTHRSSRDELAYRKRKLTERGQYEQAAMAEEEATQRDHEGKAGAETKEYYWAIFCVVLGYLAAHALVFNYYYPDDLRPNYSPDRGYFDDVAARREELQAVDEMVGLSVLESVYSKRKAAVKRRLEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQ38</accession>
    <name>A0A088RQ38_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TOG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_190220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698017.1">
        <property type="nucleotide sequence ID" value="XM_010699715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQ38"/>
    <dbReference type="GeneID" id="22574076"/>
    <dbReference type="KEGG" id="lpan:LPMP_190220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190010600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_190220"/>
    <dbReference type="eggNOG" id="KOG4825">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="66599at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22265">
        <property type="entry name" value="UDM1_RNF168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052607">
        <property type="entry name" value="CEP104-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048739">
        <property type="entry name" value="CEP104_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048738">
        <property type="entry name" value="CEP104_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13371:SF0">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 104 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13371">
        <property type="entry name" value="GLYCINE-, GLUTAMATE-, THIENYLCYCLOHEXYLPIPERIDINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21040">
        <property type="entry name" value="CEP104-like_TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21038">
        <property type="entry name" value="CEP104_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21039">
        <property type="entry name" value="CEP104_ZnF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomal protein CEP104 N-terminal" evidence="3">
        <location>
            <begin position="40"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Centrosomal protein CEP104 Zn finger" evidence="4">
        <location>
            <begin position="748"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="686"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="363"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="688"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN97364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="876" mass="95013" checksum="31F81391539D6FD9" modified="2014-11-26" version="1">MFQSEVKYGPRLDVYLCYVSSHDEVHSADALRVQDRHSCGWVSRVHAPYPQELGFRFDGVVWVNTLRILSHESKISSCMIVYVAEPTAQEEQNGVCGPYSKAVFKRLGHVRFSNNVASDYQARELKTVGLQRRCTYLKLVLRNPHANSYNMFEQIGVVALAVHGELLKKLQDWIATPLAIHIGVHATVPLDEMMPPPPGEGTSSTSARVASNLTTRVSELAAMKQKAVEEEDFDAAEAFKQQITIIEHAQREIARLELEKQRAVTVEDYKLAKKIKLRIAALREESERVATAAPNAAPSAVAATNASPSLPQLHGSSAAGAPGSAAAYDNDNGAASPHYVQRGWNAHDEIVVGGKGYYDLSDTTGGLTDNQPSNQSGSGGDEVPLAGDGAAWEVALNAAIKRVSTVLPGPLPLTGDAAAAAKPYTKDLGVYCVACLFSRKGQQREAALHGAVSSTGSQALASHSDAAWAQLVLYMSLKGFGVGDPVPGAAIAACSALTKIVEGDVPGASADQVAESVAKALPKLTARLGESNIRVQESVEKAVVALARSPFGHRRVVELLLVDPEKQHKKPASVRAHMSRINILSTFVDEFGLACYTSDGLDTRSLCSMVLLPSLQHSNADVRQVAVGLLAKLLYLDPSSTSGYLENIKLAQQALVEEQLEHYKHNQLVARSVVPKMLDMQTDPLTVQRRSSGSAGSSQAQFQRPSAPRAREVNDATAEEVTPGVSSEPPSLRAPALSSEMEYCRLRTCQFCGEYNSSFNEHNLDLHYVSTCPMLCPCPLCDQVTEICQLQQHLVTECEKRQLVRECPRCHEAVRATEYNEHVMAKKCIKAVPTQSVCPLCHERFKSGMEGWRYHLASSPGCPNNPRYYDGTGLAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQ89</accession>
    <name>A0A088RQ89_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF5745 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_211690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698954.1">
        <property type="nucleotide sequence ID" value="XM_010700652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQ89"/>
    <dbReference type="GeneID" id="22574991"/>
    <dbReference type="KEGG" id="lpan:LPMP_211690"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210020900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_211690"/>
    <dbReference type="eggNOG" id="ENOG502S5WV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="545730at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026619">
        <property type="entry name" value="CEP95"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22545">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 95 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22545:SF0">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 95 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="567"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="815" mass="88300" checksum="2D1E9718E752EF56" modified="2014-11-26" version="1">MPLYMIQSQQQPQQQVAFTAGMIMPIMNKGALAGRQASPSSSPPTPSPLSTSGSERHGAAAAAAQSKRPLAAVSAPGASGGGASSTRRSAGAVSGSDARLAAVDPISASIHAAAAAAAAAAAQSASTAGPIFAPSSGAPPTTVIATTSASPGPSQPSPLPPPGSTMAMAVPTTEEAAKEVQRQQILGLANALLTFCSIGNTRVTSIRQCTSSFFVLLYQRLFDCTIAGIDRSPNTAEKRRHNVMLVLEQLRQHPYSLEDIEAEEVVKLNEDHISRLIMVFVQVAEDMRQQQEFQQQQKQQAALLARQDAVGGKQPLAHSDHAEDFGAAKTTSGAYAPVGYTVAEVIRPPAPQQEDSAGTGGLGYHFHRPMDNFYVAPSPPLNGGATSGGGIIGPIGGSDAYMVSGGAELGEGVSPSSVSHYLDSSVMPTDNLLEEWYRNLVCPPMGGSAEETEVMSAVDPGHVSLHGGFSQRRHPCSERLGREAEVSLTSSGSPLYGTGQRRASASPTERRSPVSRPRDHRMRIHADDIVRRFQRLDEALDAQERRHRKPFVDPAASTLSTAIQGGPVEREPHERHHSRHPAPQPVSSYPNQRSDDLASAAEKRGAAEIDVGALPRQKAPPRPSPQQPMQSHAPSQQNHRPSRAPVHRLVAEPPLTRQERYFLANRPQHRIDAEQRDCKIERLRSARYLGDMQQLLRQRMRREYDSQMSAMRGSLKESIRTARKEKIDLMRRVRDENARYRAAYAILMEAAANEAQVPARVMSRHTAQLADYYATALQHSFAVCESLKQEADRRTKNELFRYAEEVSAWQQHFLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQJ5</accession>
    <name>A0A088RQJ5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Adenylate kinase, putative</fullName>
            <ecNumber evidence="10">2.7.4.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_211450</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the adenylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="10"/>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98223.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698930.1">
        <property type="nucleotide sequence ID" value="XM_010700628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQJ5"/>
    <dbReference type="GeneID" id="22574967"/>
    <dbReference type="KEGG" id="lpan:LPMP_211450"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210019000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_211450"/>
    <dbReference type="eggNOG" id="KOG3078">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22981">
        <property type="entry name" value="DD_TbAK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001694">
        <property type="entry name" value="Adenylate kinase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036193">
        <property type="entry name" value="ADK_active_lid_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47391">
        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57774">
        <property type="entry name" value="Microbial and mitochondrial ADK, insert 'zinc finger' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="7 9 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN98223.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="276" mass="30921" checksum="79C7EA773CB4E812" modified="2026-01-28" version="2">MKVPVPFMSSNDGLSEDTIKYIKDNNIGQLMEYVLRGIITEKPAKPLRYVHELTASSLPPRLALAGPPASGKGTQAGYICSYYKRTTGKKPVHVSSGDLLRAEVAEGTHLGKIAEDYMQRGELVPDSLIISIIRGRLTKEDAVMNGWLLDGFPRNRSQAIALDAAGLTPRILMVLDTPDEVLFERVEGRRTDPLTGTIYHLKYNPPPEDDTALLERLQHRDDDTREVLGPRLDGYHSMVNDLLDYYGSIMYHVDANRPMSVITKDITEYLQNHDIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRB2</accession>
    <name>A0A088RRB2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">tRNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_230680</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699225.1">
        <property type="nucleotide sequence ID" value="XM_010700923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRB2"/>
    <dbReference type="GeneID" id="22575272"/>
    <dbReference type="KEGG" id="lpan:LPMP_230680"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230013800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_230680"/>
    <dbReference type="eggNOG" id="ENOG502SAKT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2154715at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02796">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000513">
        <property type="entry name" value="Putative_tRNA_binding_domain_containing_protein_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033714">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 6" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="TRNA-binding" evidence="9">
        <location>
            <begin position="40"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN98518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="16149" checksum="86A6FED7EB7CD61E" modified="2014-11-26" version="1">MPSWVCPECDYENEARDAICAACEADCPTGGQTAAAADEDDAYAHIHVGVIVECEDAPNTKLKRLKVNVGQGNLIPVVTAATNVKQDDHVVVACVGAEVKGETVTRTTVKGFPSQGMLCDAGMLGWVGGGVGAAVTLPESFPAGARPPSSRPRGNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRW9</accession>
    <name>A0A088RRW9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Malic enzyme, putative</fullName>
            <ecNumber evidence="10">1.1.1.38</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_240750</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.38" evidence="10"/>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699415.1">
        <property type="nucleotide sequence ID" value="XM_010701113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRW9"/>
    <dbReference type="GeneID" id="22575484"/>
    <dbReference type="KEGG" id="lpan:LPMP_240750"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240013500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_240750"/>
    <dbReference type="eggNOG" id="KOG1257">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10380:FF:000013">
        <property type="entry name" value="Malic enzyme, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000182">
        <property type="entry name" value="NAD-dependent malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF32">
        <property type="entry name" value="NADP-DEPENDENT MALIC ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="9">
        <location>
            <begin position="83"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="8">
        <location>
            <begin position="273"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN98708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="573" mass="63455" checksum="122E89A93E5986A0" modified="2014-11-26" version="1">MFAKSMFHLTGASKRSVRGVDYLRNRFTNKGTAFTAAERSHMNVEGLLPPSVETLDDQVERYWDQLNRFNEPINRYQLLRNVQNTNVTLYYAILTRYLKQTLPIVYTPTVGEACQYYGDLYQKDHGLYLDVANKGKVRKMIQNLRKTNIDVIVITDGSRILGLGDLGANGIGISIGKCSLYVAAGGVKPSRALPVVMDVGTNNINLRNNPLYLGLRKPRCSDADFYALLDEFMEAVKSTWPSAVVQFEDFSNNHCFDMLERYQRKYRCFNDDIQGTGAVIAAGFHTAVKLSTIPIDQQRIVFFGAGSAATGVAESIADLATVIGAKREDTKKSAFFVDSMGMVATNRGDKLAKHKLEWARTDIPDADIAGLRTLDDVVRYVRPTALIGLGATGNVFSREMVEFMHSYCPHPIIFPLSNPSSKAEIVPANAYKWTNGNAIVASGSPFPETVVNGRTLKPSQGNNLYIFPGVGLGCCIAQPPYIPQEVLVAAAACLSTLVTPDDLAKGQLYPPIEDVRRVSREVAVACIQKLQAMGMAKEGLPDNRPDLMKVVKQAFWEPHYMPESYYLEKELIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSA1</accession>
    <name>A0A088RSA1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_242160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699555.1">
        <property type="nucleotide sequence ID" value="XM_010701253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSA1"/>
    <dbReference type="GeneID" id="22575625"/>
    <dbReference type="KEGG" id="lpan:LPMP_242160"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240028900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_242160"/>
    <dbReference type="eggNOG" id="ENOG502S82F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="243484at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="27256" checksum="442BCB53E72F93A6" modified="2014-11-26" version="1">MSKMTPKTRSCSKSTKRGRTRDAAEAPQSSWGSANTAEKKNEQRSQSARVGVQQNLERLSEKTVGFIRRYKWRCIALLAIVMVLVAVGVTVLLSPSEYPSSRERHPCLCAVAASTSNRLAKAALSRRNGVSGVHWRAEETGLDSLAFVTKCSGGAAVTLTGPFESVDQLRAALLAPFKDHRSRCVVWVTTPEAIKAVANALKELVENNALSGRAVVPVHSRAMLVLKSLESREQLKSSLPHRVVHMLTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSD9</accession>
    <name>A0A088RSD9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_250230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699595.1">
        <property type="nucleotide sequence ID" value="XM_010701293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSD9"/>
    <dbReference type="GeneID" id="22575671"/>
    <dbReference type="KEGG" id="lpan:LPMP_250230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250007400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_250230"/>
    <dbReference type="eggNOG" id="ENOG502R0C3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277834at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="666"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="238"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="666"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="691"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="713" mass="79096" checksum="255B594A000B05D6" modified="2014-11-26" version="1">MSLSGACDAIACISDATTHTQVTAIARQCEPHLGNVREVLDALENTLSTSAGVQRLMLWFLVDRLAKQHVLFCDALRPMMIHLCTHYGPARTSDEWQDFVTLLKSSLSVTFGQTMISLILLQLGEEGKTRGSGRDSNSQPAQRKQRSSTALTVHSKALRTTGAFTTKAIAVERSTEHKHLLQVKTMDSQMAMTVSSSYAPSRPVEIVAPEMRPDANAPRGFMQALPEGYMENYHEARRKRLREMMERNREEQDRKQEHEMLKRVRQDTADAAAGTHSGTGVVGGCAEWASGAYPDFADIQMPLELPRDEHGVKRGNFPLGVRFIRDAVAACGGAVELDVVVSRISTLANREAVAEFGNVREFLLIHSPTFRLVNEDGQWIVRLANNKNGEEATWKSMQCPACSKVVRGRNFARHYNCRRCITAQIALGLQGDAEERGPIAELAHTAKRVLSLREACDDGDLDALADCLERAAAVRRFRLGSTRQFAPIMKVMRVVRDCWLAKKGVEEVVDAEVTAADVSVGNLFRIFGENIHRLPIAWIEMGDVIDMCHRFTDKVVPPFNPPPRPADPRISLQNEYPGFLLCESEVDDEDLPSDNEDEFSDDEAPAFTFAPPVDVAESLFTAAFERDTKRLQHRMRTAPPMVLQRVLQTDGTQTQAEMYAEFTKTVHTHSGHHHGPNGGGGNSYRHRHGHSGGAGRGGGGGYQGRHYVRQRPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSH4</accession>
    <name>A0A088RSH4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Qc-SNARE protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_210590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698846.1">
        <property type="nucleotide sequence ID" value="XM_010700544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSH4"/>
    <dbReference type="GeneID" id="22574881"/>
    <dbReference type="KEGG" id="lpan:LPMP_210590"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210010600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_210590"/>
    <dbReference type="eggNOG" id="ENOG502SB4E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="261831at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="CDD" id="cd15841">
        <property type="entry name" value="SNARE_Qc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="2">
        <location>
            <begin position="9"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="97" mass="11058" checksum="392E010E93F217E5" modified="2014-11-26" version="1">MAERSFAQQDDLRTQDQLLDQLHASVMNTRHYAIQIGDDLGEQDDMLNRLHNNVTHTADESRRQNQNVVQLLTESESRGFYAVVLLLVALIVLLLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSK7</accession>
    <name>A0A088RSK7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_211040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698891.1">
        <property type="nucleotide sequence ID" value="XM_010700589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSK7"/>
    <dbReference type="GeneID" id="22574926"/>
    <dbReference type="KEGG" id="lpan:LPMP_211040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210014400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_211040"/>
    <dbReference type="eggNOG" id="ENOG502QTR7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="66533at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052107">
        <property type="entry name" value="HEAT6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13366:SF0">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13366">
        <property type="entry name" value="MALARIA ANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="775"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1089"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="399"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1089"/>
            <end position="1102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1259" mass="132459" checksum="80AA69CB4AD4DEE3" modified="2014-11-26" version="1">MSAPKASPRRDGHNGKSGNNRFGGATAARGGGDIRLAYHPVHNLPFLQELLRPSAASRIAAVARTIHVDDDTGSASGAVGRQLPSYASARGWFGTAPSSSVPGAASSLSPPPPPSYEFSMPPHQPIGKSPGTTPFAEATSATPPRANSLASTAMPVPPLPLVLECTMQLTGMLTQWRVSNEGKRRRPPPLPLAPTLPSSYNPPTGQGNGGSAVSPTTAVRGGGSAVQPLMPVPQSVGDGSATAPPPARPSAQRVLQMMDLVLWYCLSTAEDAGLATSGRSCGTSGFATPAHPGGAVTAAGAVFHQGLAGGSSSPFGLRGGGGGRTGSASVAGGRLGSVGRSGSCSPDPQAAQDWLDGRMSSTCSTAGTPTITITDDQLAERLFRPAVDAVVLLQGPRDQLLPPSSSASSLSRAQSMGKANHIDSSAVTDVSGARSGPIQPPAEAATDDDDATAVELQTMALWTLAAALVRFADAPFNATVFLPVLFPQVDVRSLAGAAVRHPLLHPLLHGDPHNTSLRCGAAAALTALLHKLRPTLQYAEEPQQGRQAAFLSLAAQCGTMLASLHESLWWGLDQLQQREPQSAGADSVASAPSSAAAMPLLSTYATVVAVTPYHRCFRSRVVVLQTLQLPVMHFFLAHDEAGAFMPATQLVSSILKNETLRVAKTPLPATAESRAAEQGHGKDCEIPDTGGDRNVIAANFLPALLSHADTRVEVWRCMVPLSRLYPRLVHNEFEALMAASVKVVSTLMAWEVAEVAAEAAAMATASAVVEAESDATSSRQWAAPSASATLARPAQPTAEGGGNSAKEPSVPPPMYREEGSAGLDAGTASPLPQRSHVPTSSLDAFAECLRTWLHYMGYIWKAFDDNASDPAQRPEGQLYRATLAHKQRIHEELLRPAMRLRRCGGDVRTMTLRCIAQIGNDYVSTVADRSLCEEFVSYVQSSAADAQPRVRGEALTTLGVWLWQYTSMDGFVFIAIDSAVHVLTADPNPVVRTKAAFALSNVTGRLSEGSCAVVRDSPDYIATLCGTAMHAVVIDTESGVQGHGIRMMNHLLQVLTFEELISEVEEFEEGVAEGFLRVLLECLRAKTRGSHDNEQESGDRGRGSGGDGVAPLRCAAPHEAKHRWNAACALGMGLAREVVFEAEPKYAVEAVEALCTAVVRDHIFKVRTQAARALGRIPGHCLSGTYTATDMTSTVVDSLCKALGTATSTENFRQYKEQGSLHDALRSALAVMMTSATPSNELEKVFTSHMKLLQKEGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RT24</accession>
    <name>A0A088RT24_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_221060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98399.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699106.1">
        <property type="nucleotide sequence ID" value="XM_010700804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RT24"/>
    <dbReference type="GeneID" id="22575152"/>
    <dbReference type="KEGG" id="lpan:LPMP_221060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220014000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_221060"/>
    <dbReference type="eggNOG" id="ENOG502RX78">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="242517at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98399.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="450" mass="49317" checksum="B44BE70515BBF4F2" modified="2026-01-28" version="2">MSSQSAAAAASKALVRCTRRIRDPLNYLAMQPTDPDQVTTSIRTTDAAMVTWFVPLHSLQYCLHKRYEAEQFGEMILPKGMAVPEAKPLTPTEERVKAAVARRGPSVVPQFMRMTAPRSSGAADADAAAAGSPSASLSSRLSSPPSPSAGGNQLNNYVNEAGDTVVPLGLVTMIVGNNIPAKQSWLERLVDPAPHPTLSMRVMVVDRIHWQRTSWLAGSICSSLCWGRLPQRIFSINLDYKNPVYISGGSAADAAAEESAPVSSRHARQPLVFDTVAQRYTSPFQVDVPGLNFRLKIEDTGKTLFDTSSRIVDGFLDNESALHRLALSREVNMLGLGGSVYRQALWSSPSLPNVGRIVKCEFGSLFERYFGCSPVGDPVATWLVDAVEKTLIYQMEGEVEDENDPNSATTYGDRSLTERVQKKAMNRYNGFRDDIRRKTYSELAGDEVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTE2</accession>
    <name>A0A088RTE2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">GAT3</name>
        <name evidence="10" type="ORF">LPMP_270460</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700134.1">
        <property type="nucleotide sequence ID" value="XM_010701832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTE2"/>
    <dbReference type="GeneID" id="22576222"/>
    <dbReference type="KEGG" id="lpan:LPMP_270460"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270011100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_270460"/>
    <dbReference type="eggNOG" id="KOG0060">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002587">
        <property type="entry name" value="Multidrug ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF63">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="93"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="444"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN99427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="688" mass="77376" checksum="F6116085274B21A9" modified="2014-11-26" version="1">MPQAQFHLQTSNSMTTAMYSMSVARRLGVTGTCAMFTVTLLMQRYYLRLYGQTISGVHTEDDTQVTWELFHCFFQIARIALPTWRCREAVGSVIFILLFAVKAVLRVWVSKANGEVLSTILHGVRSERLPRFVSKVMVRIALGLATGMANGAIEGLRSWLIGCYRERLSRTFQRRFYKHLVYYQGTMLDNRLEAADTAISTYCGEFAEHFAELPYYFVLPGLGCVTSMVALVEQAGLKSALIMSSIATSAVLVLRCLTPALGRIHSQLLMREDDYRRMLTNYLSNVESIAMHAAGEYACKRLDTSLAMLKESLDHMALAKGNFEIMEAAFSTLMTVVAQCVTFSGARRSHYHRSLNAVYLEIQLIEDLNCSVKDFVVNFRELSHLTEFSTKMAEFDNTLRSIAAGTFIYMHHNPGYVSLPGSPLVYTQMKNITHAPDAETFPLVKMEDLALESPTGQHLFSGMNVELRSDEDWVILGENGCGKTSLLRMLCGLWLPKSGVLSQDTSVRFFLAPQHSYMAPQCTLYEQICFPDAVEAPTLEIRTLIKEALDLAGAQTVVSIIGGYDSAVMGLDPSNRDESYSWSSLSGGQKERISMARVFFHVLRMDRTKETPVAILDEATSMMDDTEQDVLNHLRRMNVRMISVTHREVVIRHHTNILRIARGGKWSVEKVHNPVKIGERVEAERTTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUH3</accession>
    <name>A0A088RUH3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_250590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699631.1">
        <property type="nucleotide sequence ID" value="XM_010701329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUH3"/>
    <dbReference type="GeneID" id="22575707"/>
    <dbReference type="KEGG" id="lpan:LPMP_250590"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250010700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_250590"/>
    <dbReference type="eggNOG" id="ENOG502RYGS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269386at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="190" mass="21824" checksum="653FB6B5634CCC4D" modified="2014-11-26" version="1">MRRLQRTTLRLGVLAMTRRAIIPGHIPTEGTRHSGNNQGWEMRRGHHLQSSIGLHTPIKTACGREFNPQVYYEVLQACCDQQWLVAIQRELRTDTEYINYLRQHGGAAKDMRILTDGVQHDDEFMAKLKEKLKTDEKVSLTLCAVQQSYERIRKKRDLHETQVAADGGRDPYASMKASRKGDFGSQMPQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUV1</accession>
    <name>A0A088RUV1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_280020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700347.1">
        <property type="nucleotide sequence ID" value="XM_010702045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUV1"/>
    <dbReference type="GeneID" id="22576447"/>
    <dbReference type="KEGG" id="lpan:LPMP_280020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280005100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_280020"/>
    <dbReference type="eggNOG" id="ENOG502S4SD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="238175at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="105" mass="12125" checksum="B3DC300699F4D4E4" modified="2014-11-26" version="1">MGCPWGGMHHGERIHDLLVDEARFAKKGYLESVPIEKLDEGTYQRKFKWDRGMAEYGNSGYRFLGVLPMWRELYFVRDGKISLVTSDKLLKRRSLLHALFGFGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUZ3</accession>
    <name>A0A088RUZ3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_280610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700402.1">
        <property type="nucleotide sequence ID" value="XM_010702100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUZ3"/>
    <dbReference type="GeneID" id="22576506"/>
    <dbReference type="KEGG" id="lpan:LPMP_280610"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280011600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_280610"/>
    <dbReference type="eggNOG" id="ENOG502S89J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="245371at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="95" mass="10382" checksum="9B9E540A58FFDA91" modified="2014-11-26" version="1">MAQKSLRSKSKHKSAGALRKYVGEAKKKSTYTKAKKTPEAKARANYISAVESAMASRVPSDQRSKLSIVKSSGPTLAKKHIKKPLTRGRKRKGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVE6</accession>
    <name>A0A088RVE6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zn-finger domain protein, putative</fullName>
            <ecNumber evidence="7">6.3.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_291700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.2.-" evidence="7"/>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700775.1">
        <property type="nucleotide sequence ID" value="XM_010702473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVE6"/>
    <dbReference type="GeneID" id="22576933"/>
    <dbReference type="KEGG" id="lpan:LPMP_291700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290021200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_291700"/>
    <dbReference type="eggNOG" id="ENOG502RZHW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16495">
        <property type="entry name" value="RING_CH-C4HC3_MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20893">
        <property type="entry name" value="LD08641P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20893:SF2">
        <property type="entry name" value="LD08641P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="519"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="562"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="628"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="946"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1051"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1084"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1107"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="6">
        <location>
            <begin position="70"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="375"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1163"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="395"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1168"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1196"/>
            <end position="1207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO00118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1220" mass="135954" checksum="DB6D7361134DC06D" modified="2014-11-26" version="1">MQELPRRGARKARREVTVEPLATAAASPTSTVDKDKDAQRSGSAEDDLSDALPPTTPAVASSLPASTRNSASGSTIECWICFDSTSIPSNPIVTHRCRCRGSVGYVHQKCIDRWVIQQRNRACRSCGASYQLVHSEYPHGANLPLRPHERRMFLFKHFIKPLLLESAETLCCVLLRFVIIPLLLGLVYSFNRWSLLWQPMATTLSAFATSSKRNSSHTTSSGVPGSQEAWEEEGSAYTMTESFLAWADAILFGLVLCTVMNAVAVGWKKWDHYFRTARARLARETARQAQEEELARIAAVLPVGPLHFGEENDARAGEGERAEAIEEWMHNDAPQPQQRHHREALPEGFGVEEWRLEWGPLRAAENVPLLREDARGARQPEARAAGDEQHSSGDSDSDGDGDSDSDIDTSYRLSFVDEVFDTIDRLKSGAGGGGMKRLLPSSIWQLCYGLALTLLLRSSCGRAVAALAFAGFIVSWRYRHTRNVLTTQKRRIYEVAERVPLLSQEEVKTLFGVYLVDAFFFYGALPELGGIMLHYAVAPYIDVGFDRGFLAFLHGLTVLKVTLYWVVGAVLVMLLTAMELTVVGPLFANGVDLFFVRSFDARWDSVLGYWRCVVTQIFDSDPSRIVRGFLRVAMVELLVLLIFVRVPLWGMLGFRDFLWGDGTAPLTGRPLKMSLSLGMTTGYDIGMADSFHEWRRTEVLRLLAEQVLLPFGAMYSARVREQLTQTSESIPFGTIDTMMLAAVSSTSMTLDAQELWEQVWGNMSDRSVFLFHIIDPVSANKVAAASEGFRNTLVRLQKPLEWLRVATAEDGVCNTLVALSSPAGWVKKPQLEMPAADLEAIVAPPSAVSEHKCVSTARAHQIVLDAWRRTYHNTMSHITGALSPEAMPTPPSFYVENDSVKVEPHTVSVAKCYMAALQLSYPYLGMGRWRALTYEWWSLLLLRNTFLNYIVNILMLVASVSTVLSCFAVYPLQRAQLRILFPVVRWIGQSVVHMEDYLFDPEQLRAVEGFVEQEGEDELVLPPMVEPLGFDRREEYVEKAAIPSYLLLRRVVVAVLFLAVASVMVWMMPVLCGTLLLCITKNALPVFVGAVALSFFFWDPMLFARSIIFGMALTIAIAFAVPIISILYICPFVRLFWSSYPSLVEETFERKYDVHQMVGRYPGSDASSVDDTDGELDSDWESVDSRDAVDGNAEAEVQDGEAEPEVGDEPHDGVEDVPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVP3</accession>
    <name>A0A088RVP3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_262260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700046.1">
        <property type="nucleotide sequence ID" value="XM_010701744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVP3"/>
    <dbReference type="GeneID" id="22576129"/>
    <dbReference type="KEGG" id="lpan:LPMP_262260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260027400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_262260"/>
    <dbReference type="eggNOG" id="ENOG502SBTW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272738at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1053"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1186"/>
            <end position="1213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1233" mass="135781" checksum="6CD1A1EBED8974D0" modified="2014-11-26" version="1">MMGYEGRCVLLDDTDEWVNIPFVVREFMKQLNDEAQSSRVVVESLRQEQKETSLLLRRVMQKQADLEIDNTRNILSLNHHASRVAYDSTMKRHTEQIHYLRKKADAFDTKMQHLSSHVEGLSQAALSSTKTVGAFGELKGLVTGLSTKAETTERLLKDHIDAYTVAQRPTESLVDTSALAAVTDIQKAFKNQLDVYSARQSSLEKSVEVLREASSTQEEESSRIRGICGELSQIVEVDQKTNKDRLTSCFNTMEKLEKLCVAQHAELETRMKRAEETSLGCESRSHEEVKSLYAELGGLLKENQAETRQRCCELAEELRAVKEQQRRLVEQLATANHEVESVTQRAVKQMKDISVRLASVETEVEQFGATFVARRDHQKEQRQTQESLDIVRSSVADTVAAFQAQVQQLATSVKTMRTEQGEDNDWLHNELGRIGTIVGYTSQQREKQERQVTSLCEIVHNLSVAVDGLQKGCGAAAAPSPAPAASPAQANTPESCINHEVPAAWETWRSTFMKDVEGKITAAVSPNLQPYTSPPVLERVSQQLNELTAKVDGGAKYTQAIMSQQMDQIRHIVRDEVMHQLQSHPVLREVTPALAEVEAVKRRVAGVELSLHTLPARADRWIVDSEAGGLSSADSVLQRVLVVEQAIEDFKRRLLELGEHVIGVDQRGNQLACGAHEMEAQLQDQQRMTLKLGTDLTAALESLLHTEQSLSLHQSSTALQLSEVHTWLEKWKRDAAAAPTAAAPSVEPPCAQKGAVSQTSADGSCKSLSAGVAQLAETVERLSAQVARVETDILHAVHADLEAVRSECAAVAAARKIEKGNVSSPTTNALDTEEVHAAYKELQHRLDVEESLRHEAEAAFRAVEARLLAVERCASELLSALPKEVSPSAGDADSTATAAAVAYCTGELARCHERLDVVQHQLTSNTCRCASEAERDVHCRDVHRLQQGLECLQEDMQAFVASQLCTKVREAEPALVEAATTAAVLRCQEALKAAAESTATAVDAHANAKSVAALQAAVEAVQRTLDEHISTVLEGRDRVEGMAQVLGATVDSLNGLETTQLELRRELERVQSAHQAHQRDLSLQLETVVSSIETKVDELRANVKGSAVVSAAESLEAGNCAQKPSDNAKAAWVAEVVDSMHTTYYTRALLEERLENIWSSMISLLTRKEDVSAVHDKLNGLHQLMQEEMQIELQRLEEQLANQLAEKVSLANLQDILEHHIFSSDAHSDDIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWJ5</accession>
    <name>A0A088RWJ5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Intraflagellar transport complex B protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_301740</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IFT46 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701199.1">
        <property type="nucleotide sequence ID" value="XM_010702897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWJ5"/>
    <dbReference type="GeneID" id="22577227"/>
    <dbReference type="KEGG" id="lpan:LPMP_301740"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300021600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_301740"/>
    <dbReference type="eggNOG" id="ENOG502QPNA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2119217at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022088">
        <property type="entry name" value="Intraflagellar_transp_cmplxB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13376">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 46 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13376:SF0">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 46 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12317">
        <property type="entry name" value="IFT46_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO00399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="361" mass="40144" checksum="1706A3FED4AE4D4E" modified="2014-11-26" version="1">MDSATPSAVLGGQLMTNNPNDERIEVRNAENVGTPRAALRPSYAEEVTEGRSGGMGKPIENAPHDEAIPVSPSGSQVATPMTMRTGQMIPPDDDDDDREEEGEEDEEDTELDEGREYRAEGYAGQKPIDLTEAAPLMQAGDLQLGYNPAKYSRINATANREMQDLFKQIMKYEPFTAELPAKLRPFVPDYIPAIGDLDPFLKVPRPDGIPDGLGLEMVDEPAIPQSNPAVVLLELNATNAHGVAADIVDSLENAANRPEVIDRWISDIKKVHYKKALPTVNYQRPMPDIETLMQVWPQQFEEVLNSDVAFPPSNINLDLDQYVRTLCAILDIPTYSSLIDSLHVMFTLYEEFRSNQHFQHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RX74</accession>
    <name>A0A088RX74_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_282310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700571.1">
        <property type="nucleotide sequence ID" value="XM_010702269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RX74"/>
    <dbReference type="GeneID" id="22576676"/>
    <dbReference type="KEGG" id="lpan:LPMP_282310"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280029400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_282310"/>
    <dbReference type="eggNOG" id="ENOG502RXPU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="242255at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="245" mass="27669" checksum="33EB178CC6CBEF82" modified="2014-11-26" version="1">MERAADARREIYELWSSTARAEEHVQSSATSMSANETAAAEAKAAEERCEAVARLLDKHKLDPATPREEDVSRGLGDALDRLLLLCVPLSSRHGTDLLVKLMQVSARQGRQFSMRTIQHLFARTNGYAEALAVFYAMRRSNFAMSMEAYHAMLYSLQRLEEEGWAARFHEEFTASNGEAISEQALDFVLRGVDNQLMPENKPWLGRIMFAEVKDSVATQRQSMKSFDEMGQLWVQRYKKGGSAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXZ5</accession>
    <name>A0A088RXZ5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_312920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701674.1">
        <property type="nucleotide sequence ID" value="XM_010703372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXZ5"/>
    <dbReference type="GeneID" id="22577718"/>
    <dbReference type="KEGG" id="lpan:LPMP_312920"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310037300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_312920"/>
    <dbReference type="eggNOG" id="ENOG502S4MT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265173at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="27082" checksum="EF2A68D8ACFD4E9C" modified="2014-11-26" version="1">MWRAMRRTPCSVPLMTVARWQSTSGKDAGVAAGPDANGNGEASKANSTASVKTPDAVSGSSTTQDSAKSDAYCFPADEVLDAVKKRDFSAVQTHATKLVQSQWREEYNVPAACVVVFFVMWYWIAWTRRSIRRKCEATEACVKQQTDEMVEIVRNMTEKWKYDMAKANRQMQGIIDKNSELTRDIDRMTTALRSCSIRPTAASAAAIAPTVPVVKRVNPSDSEATAEAAQTAAAEGSEAPAAVEDYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RY29</accession>
    <name>A0A088RY29_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Serine/threonine protein kinase, putative</fullName>
            <ecNumber evidence="10">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_312720</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="10"/>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701656.1">
        <property type="nucleotide sequence ID" value="XM_010703354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RY29"/>
    <dbReference type="GeneID" id="22577698"/>
    <dbReference type="KEGG" id="lpan:LPMP_312720"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310035200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_312720"/>
    <dbReference type="eggNOG" id="KOG1151">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13990">
        <property type="entry name" value="STKc_TLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000256">
        <property type="entry name" value="Serine/threonine-protein kinase TOUSLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974">
        <property type="entry name" value="MIXED LINEAGE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974:SF23">
        <property type="entry name" value="TOUSLED-LIKE KINASE, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="358"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="62"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="651"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIO00856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="677" mass="75767" checksum="44D290C148E0D105" modified="2014-11-26" version="1">MEAAPVAAAQQPPQAQKRPREESDASPQEGSNDSVPATFSNEHSLTTPVVGAELVVDVDQSETNAQASAVDSPRSRSRGLPAVGPGPISPVAASRSGTEGASSCQAAAVVATLGSSSSAFADARRFKQPTLAAYGMVSDTIALKKEISDRDSHIEELNREVEGLRAEVGRRDDQIHFMDGQCRQYQKKLEHFQSVMRQEMLSAAQKDRSEARRVLYQKHFELGQTATWHSNGQTVWMEGDRVRTLFLTLASLTQKREEAEALKKAAQSSVKHLARQEREREDSSAGADLQDALMAAQMEYQLRTSEHAALTNSIADVKLKQAEVEHEKKAFVKEMRRVNDEDTSEFLAIPTIGEGDRYVLMHLLGKGGFSEVWKAFDLVEGRYVACKIHHIQREWPTQTRTHYLRHAQRELDIMRALDHPHLTHLYDVFPRGDNMFISVMEYSNGMDLDTYLKRYRTFKEADARLIFLQVVDVLRYLASLESPIIHYDLKPANILLHRDDPTILDIKITDFGLSKIIGATREGPSDNPSIELTSQGTGTYWYLPPECFETASTPRISNKVDIWSAGVIFYQMLFGRRPFAEGESQRRIWQEKLIIQSARTLHFPDAPKVSEEAKDVIRACLAFNEHERCDVFQLSQDPYLFRTSRRSTHKAKSAALPGGGNSCSPLMPPVADATPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYK3</accession>
    <name>A0A088RYK3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase</fullName>
            <ecNumber evidence="4">5.4.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_301540</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="4"/>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701180.1">
        <property type="nucleotide sequence ID" value="XM_010702878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYK3"/>
    <dbReference type="GeneID" id="22577207"/>
    <dbReference type="KEGG" id="lpan:LPMP_301540"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000021400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_301540"/>
    <dbReference type="eggNOG" id="KOG2554">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25767at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160147">
        <property type="term" value="F:tRNA pseudouridine(38-40) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.580:FF:000022">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.660:FF:000025">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF5">
        <property type="entry name" value="TRNA PSEUDOURIDINE(38_39) SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="6">
        <location>
            <begin position="198"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO00380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="499" mass="55350" checksum="8FEC2C8A9C812F90" modified="2014-11-26" version="1">MTSSSTADNHSEVAGTVAASTSICGSREVTASLPMALPILRGTKKEKTEKAFSFNRYPSRKIGLRLAYHGHVHDGLAKQKETDNTVEGLVCDALRRVRLIPEDGPHNFGRCGRTDKGVSALGNAFSLTARASCTADADPQLPPLDYCSMLNNVLPSTIRIVGCALVDDRFDARFSCVHRTYRYYFCHRGLNLAAMQEAAAFFLGTHNFRNFCQMDVVNVSNFTRTVLSVGLHPSEELPELISYLEITANSFLYHQIRCTMEVLFLVGRGLEAPSVVQTMLELGDCKPTYPLADGTPLILWDCAFDNVQWQLSHSAFQAAEQVLQDISTALLIRATSAAAMRSQLFRWYTGTVDVFAREKLEEEDAAGRVRSCAVVRHDPEVRRLDGWSITGCDWTESGTARRMKARKRDLLYYIRTDANKGKPPLATTSGEAKASPAAETRASTPLMPMNYVPLLQRETERTYEEEVRGLSDKKRARYEVNEAKKAAGAAVHKEMTGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYX3</accession>
    <name>A0A088RYX3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_302820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701305.1">
        <property type="nucleotide sequence ID" value="XM_010703003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYX3"/>
    <dbReference type="GeneID" id="22577335"/>
    <dbReference type="KEGG" id="lpan:LPMP_302820"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300032900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_302820"/>
    <dbReference type="eggNOG" id="ENOG502S4A9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264083at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="423"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="52861" checksum="FE8E72761C15AA8B" modified="2014-11-26" version="1">MFSTFSDWAVSAADTLASISNQGIEVVRYTGVLDALESVSTNPNSTAEAAASNEKMLSVPDIMTPPTSWAGSEEEWVWCLEAALRDPNTCAITPAILRADAPLWEEMKKTIAHLLAPPSEPGKKDSPTPTPTDSEAGGSVDVAAKLFERTGGAYTPASDLVKYIQEHYEVYQVRSYIVPRFTSDEDYWLNIAWRMGLYQQCTDAGQLLGLMQTLSRLPQPLRDIAAAMEPTSAPAPVTFGSAQHEEGSNSHQNGDEDRDRKDEAEALHLKDNTEYWHRIRMQYEAIQEKLAWLREMEERVTKEMELASGNVKLLGSLLQRKEASTALGASVLDSCQYHKVKLSRLIADICAAPAEHSEGTLLDSRSGTLFHALLKCNDDVKAVLETYAGYPPSGPESPKRVESSSSASPAPASTKQNSPAPCEESTTEANTEESTTSPLTKPQCTSGSCPIELRAAASGGAHQPGSDDVDKDEESFEAKLPWSMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZF4</accession>
    <name>A0A088RZF4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="3">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_331010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + nicotinate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAPRTase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="3"/>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702194.1">
        <property type="nucleotide sequence ID" value="XM_010703892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZF4"/>
    <dbReference type="GeneID" id="22578254"/>
    <dbReference type="KEGG" id="lpan:LPMP_331010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330015000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_331010"/>
    <dbReference type="eggNOG" id="KOG2511">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="193380at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034355">
        <property type="term" value="P:NAD+ biosynthetic process via the salvage pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.140.10">
        <property type="entry name" value="nicotinate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00570">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041525">
        <property type="entry name" value="N/Namide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006406">
        <property type="entry name" value="Nic_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01514">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003704">
        <property type="entry name" value="PRK05321.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098:SF1">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04095">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nicotinate phosphoribosyltransferase N-terminal" evidence="9">
        <location>
            <begin position="15"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Nicotinate/nicotinamide phosphoribosyltransferase" evidence="8">
        <location>
            <begin position="185"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIO01394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="413" mass="47052" checksum="9DA9A7C0E829B54A" modified="2014-11-26" version="1">MTHSNEFRPIIKSFLDTDAYKLHMQQAIFHQNPTVITAYEFNCRNKEDHLGIYADLVYVQVQHMATVRLTEPECTYLATLPFFKEDYLEYLRGYRYKPEQVHIRAVPQMLTCENEFGEDGSDLAVTVEGPWVETILWEVPLLAIISEVTQQSRHPCIGPAEALVTLHEKLDLFFANHTEAELATFKVTDFGTRRRCSQAVQEVVVRALKDDTRFGPHLIGTSNYDLARRLGLPPVGTQAHEWFQAFQQLSPELRHFQIMAMDYWLQEYPQCLGIALTDCITMDAFLSDFDTRLANAYQGLRQDSGVPVEWGRKAVAHYKALGIDPHTKTLVFSDGLDLEKAVELYNSFKREIQVMCGIGTQLTCSIKGVRPMNIVIKMVRCQGKPVAKVSDSPGKSTCGDLEYVEELKEVFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZI8</accession>
    <name>A0A088RZI8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">G1 cyclin CycE4, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CYC5</name>
        <name evidence="2" type="ORF">LPMP_330830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702176.1">
        <property type="nucleotide sequence ID" value="XM_010703874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZI8"/>
    <dbReference type="GeneID" id="22578236"/>
    <dbReference type="KEGG" id="lpan:LPMP_330830"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330012900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_330830"/>
    <dbReference type="eggNOG" id="KOG1674">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="244495at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000164">
        <property type="entry name" value="CYC2-like cyclin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF112">
        <property type="entry name" value="CYCLIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="645"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="658"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="775"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="883" mass="95143" checksum="D8B7D5285EBAFE01" modified="2014-11-26" version="1">MPGSRVGSSLGIPTLAQRGAAQLSAAADAFSMERFAAFYEVALEELVDECERRVTNAPAAWRDSQRQLIGGDMNRDLATSTHSFDSPRSSAMSPLGRVPSSVALNCNALVNLPCFTSPLHNTHGLHLRELSGDIEADPYRTSAPLPPLSLHTGTAFFSVAGHARQEEQETTVGAKMTVSTLLAALGRHHGKMAPMVFIAGLAYLARVTMQCASEFLSVTRANWYRLTTTAILVAAKVYDDHSSSRLNACFARSSGIPLEEMTRLELDFLYLLDFDLLLKESEVEQWLIWMETLALRRDVMTPLNSYVLGTSASMVAAQLASPPKQALTSRPTLSENWERSKTGTICEASRTPGLSSGVLGGEDETVRTSSSSAAGPRSFSQVHVASNSMETAHGVVDSAASSRCLTGAAAEADMPSLTAPLADLPSFPLRSAASSMLLPPSLLDGTFSAVSAASLPGGAPSSLNDRRAFVPPLPIHNALPLRPPMSRTRLFSVVHDTAEPPSPISVRQLCRLSGSLPSPLRPPSVERHPPVRFFKSQGTHPHGPSRHVGGAAGSTDLALYGTVDSGCKVSKQWFHERIKRAGRARTAGRASAPVMTDAKCCPDSAASHQHKKRWGPFGMVQHVRDVLGVTASLVRGQLNVLAPSTHAEEVSRLPPPQQQQRQSRSQPVQWSTNSVSGSGGRVSLQPQSFAAPPRCSSSGGTYPPFPAKLMEEPKPQAGGAPPATTIMSLVPTGFPPQPSPAGTTRHHGDPASSGDSARRSRTPRSSPQRVDPYSSAKSQPYASTVANVTVAQPTARKAADEVYADGDYSHDEEDEEYEECEYGYYDEDGYFHYYDDKGVEGEYDDYCSEEEEEEGAWYEEDEEDEAAYFQRCRRPLTHSPPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZZ8</accession>
    <name>A0A088RZZ8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_340610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702488.1">
        <property type="nucleotide sequence ID" value="XM_010704186.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22578565"/>
    <dbReference type="KEGG" id="lpan:LPMP_340610"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340011600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_340610"/>
    <dbReference type="eggNOG" id="ENOG502SJWC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273888at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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        <location>
            <begin position="147"/>
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        </location>
    </feature>
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            <begin position="209"/>
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        </location>
    </feature>
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        </location>
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        </location>
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    </feature>
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        </location>
    </feature>
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            <begin position="1106"/>
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        </location>
    </feature>
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        <location>
            <begin position="1193"/>
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        </location>
    </feature>
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        <location>
            <begin position="1235"/>
            <end position="1245"/>
        </location>
    </feature>
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        <location>
            <begin position="1247"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1298"/>
            <end position="1315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1533" mass="157409" checksum="03457C37AB213A0E" modified="2014-11-26" version="1">MPAKRLNPAMAASSTAAHPPRRRSSALLSSNTNGSERWVSAASFPPVATVVPLPVKKSGLKSLTYSSGDANAPHVGTKVLAATAKAAPARSRAAASVPANHTASPPAAPELVPSRSPAIAPMVQRAPTLSNRSAASIAHAARRPRCSSSTPSVTAPPATVDAAGVSPAVANGSSKTGLFTASTAPPSLPTAKHASHYAYIGTNFDAAPPTSTSSCTENPQANWSVPASGPRRLSSASSNATKVMTSASGAAATPSAPVPEASASHAGPRDAPAPRQRANESTASTSKPNGQLTRAAAPSTDSAAAPGASSCLVAQASLKPSVSSSATGKKVIRRAVTGTDTSGLLSTTTTSRRPSLSGTATADNTTVPKRASSVLLPQPQSSGGAVPTLDAEGAPSTTLNTARTTAPTAFNTPTNAGSTVSGRTTARLSRGPVVLEEWARSIIKPGDEKLLYWTRVAGATSCGFTRTSSGIGMNSTAASAARQASTLRSLTNDTQLRRAQKTVLRQRHTETSTPSWRSTKAASVGAGSVASVASGGSDSRFGSTVKRSGVSLLRRQQEGKDRQRSLTATMATPTGGNRGSVGDGRVSNTSAAVGSASPTPSRISEASTNTTMRGNGRLSGSGARPLLEQLPGGAFVQAEVIGQRRSPSLKLFAKPSPRMISAPNPRGNTGAPGLKTTFGVNDGPYYVGNEELTKLTWVREEMLRALMQSAAPLAMSAATKENSAAVAVASMPNPKDGGNANILESSSSSLLTMHFDPVVSGTARASPTSLSVGKRPRQRVYSVDLRGGASNDDPAPPMQPPAAGVAQPRGRLVSSGTTPVLASSIRQKPGNSVSLACPAPTSTPTGVGTTLVPTSARPTLDSSAVVAGEPPPPLRQRGERQPRRPAVLVALSSLQSPGTVAERVRLEFVRQEQKQSTAVPTGKKKAPVPSSVVTAIQRPTAISINAATRLLLLDPLFPLISEENYQRLVLQNDEYTARKALLAHIAATPGAATAVSHPYGSPSPVPPLDVGKKPRKSEAEAPRAARALETDLAEADEPAPVLPLTVAVLAPTQVVAIETGAAAAPLSPSVSPPNAAIIGSTPPRRPSLQHGGPALYATFSPPRVTSPPNASNLTSPIAGSAAGFGGTTSPAHDSRLLVNAVMPTEKPGSIKLLAAGSAWYAVTRVSESTPSSTIQSSLHAGLLATACGGGAARGTSNSPTRPRSTSPMASCSSLRSVTRRGSLLQGLQQHLPHQATRTVASNHSDSISDEDSTASDEAVDLAEAELRKTLPHWGPFRTSHTAASSASDILWQKRATNPGTSPGSTTASTTTPTAARKTKSAHEETVPVASLTDSTPSLLSMALTLSPAMAKELQAYVHEFLKRYRGADSVTAEEMGPIPKTPLALQRAIRHSLRLSTESSASGVGDEEAVELEDALDDGSYHSQNVQYILGLMGSLLQGETSFCEDDDARTASGAHLRTAAAERHRKEQVTSAELIAAVMGRPLSSTVEDTTEGAALNYTRNDTSRSAAARPLLKLHDPELRAVELLFVNGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S077</accession>
    <name>A0A088S077_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Trypanin-like protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">LPMP_341660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702593.1">
        <property type="nucleotide sequence ID" value="XM_010704291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S077"/>
    <dbReference type="GeneID" id="22578671"/>
    <dbReference type="KEGG" id="lpan:LPMP_341660"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340022500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_341660"/>
    <dbReference type="eggNOG" id="ENOG502QQDA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="767661at2759"/>
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        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048870">
        <property type="term" value="P:cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039308">
        <property type="entry name" value="GAS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025593">
        <property type="entry name" value="GAS8_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31543">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31543:SF2">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13851">
        <property type="entry name" value="GAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Growth arrest-specific protein 8" evidence="2">
        <location>
            <begin position="210"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="136"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="265"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="454" mass="53388" checksum="4ECE4C1E108050EE" modified="2014-11-26" version="1">MQKGGAAASTVSEVATPPVDGKDIWLATDALQKTNAMRNYFQLERDRIITFWNISKKELEGVKESIREKEQEKAEQAERHEVEKQIFKQKIRHLLYENQVHVSTMKEEAHRALTSREEEYRAKESNVARNLRDTKLADRELEVRHLEQQRALLTQQDKEIAEQQSNFEREIKEMHLKYEHLLKSLREEMDEARKEELARIEERKERHIAELKETHERTFKEIKDYFSEITSNNLETIRTLKDEVCARKRTETHNERTMYEVAQRNKRLTEPLAKLQSQKKSLESELENYLANKEALAEVKRSIKDTQQEIQTISWEHEVLLQRYTKLVEDRDIILKKYNAMLQDIQRKSAFRRVLIQKKLELVQTQLDGRDAKLTELLKRANVNPDDMKELEQKVHDIISEKDKTVEDLKQLLLRLTTQSERVVATYESYMECNGVSGWVGTPGSTSVAASVCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0V0</accession>
    <name>A0A088S0V0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_342680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702694.1">
        <property type="nucleotide sequence ID" value="XM_010704392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0V0"/>
    <dbReference type="GeneID" id="22578773"/>
    <dbReference type="KEGG" id="lpan:LPMP_342680"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340032900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_342680"/>
    <dbReference type="eggNOG" id="ENOG502SIIA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273074at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="553" mass="60836" checksum="E330FEF8BBF60D5C" modified="2014-11-26" version="1">MCFVSFCGIPHSRPNAWEVLQVPPPATWKDEDDTPHLSLEVHELKFYADFYKEHHTCCWPRLVLDAHLGKSSEEVAHAQSTSTASEDLGRTSPGPSGAAEDAAGASLALYVNHVAEVMEQLYRSQLAKVPRTAYARRAVFHQGVPPVLRCHEHNDSFVYLVSGQLRLFHRCRTRKSVRAHQVDECESRCTHGPTVEDVARDLFPLVLIMAPRDDCAAYVDAEPPVASAATQWRTKPLVLALERVEVVGSPSLNEAGEEDQVWCAAYTPFTWVCNPLGNQKASVLAKSPAAMRRMPRTQQHDAVKSTSSKGTPRAPLTLPGAAVGDSLQPLCLSFMVYASQYTCEAVRKRVVQSLASRDVYNLHVTKSMRFGLGGADLYKRTVLGTDVEALSHARSRRPAQLMRLLDDQLECVVNGTSKAADSEEKRNITSGDGATREFVGSPPLKLPRHEADGEAPLRAGDVKCQLPRLVPSVTTYPIAQLSTLRPIVREWCRLPRSTTLASVLPRPTSITSPHSGWPLRVRRHSNEGSAHVVELSSLATLWDLAAALRNVPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0W9</accession>
    <name>A0A088S0W9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="3 10">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_342880</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="3 10"/>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702714.1">
        <property type="nucleotide sequence ID" value="XM_010704412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0W9"/>
    <dbReference type="GeneID" id="22578793"/>
    <dbReference type="KEGG" id="lpan:LPMP_342880"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340035100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_342880"/>
    <dbReference type="eggNOG" id="KOG2628">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="422086at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025770">
        <property type="entry name" value="PPMT_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51564">
        <property type="entry name" value="SAM_ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIO01914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="266" mass="30644" checksum="CAEE6E8643922ADB" modified="2014-11-26" version="1">MSYSSKQGQEEGTPNEMRRINRELRRNLILETALIAFALGVLTVVSVLLTAYGWHTHDDNLFALGLYILVAHLAFHIFEFLAAAFTRPHDTHPDAFMVFHSTPYLIANGTSLLEFFLEAYAIPEGWKLDPTRHPLLGFFLRVNCASALLFTLLVAVFYGIRVMSMLQCGTNFSLMIEDERRSSHQLVTQGLYRYLRHPAYFGWFWRTCCAQWILANPVSAVVHTVVAWYFFRSRIAYEEATLQRPDYFGETYKKYMACTIVGIPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1F3</accession>
    <name>A0A088S1F3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AMP deaminase</fullName>
            <ecNumber evidence="4">3.5.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_344650</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.6" evidence="4"/>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702884.1">
        <property type="nucleotide sequence ID" value="XM_010704582.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22578970"/>
    <dbReference type="KEGG" id="lpan:LPMP_344650"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340054300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_344650"/>
    <dbReference type="eggNOG" id="KOG1096">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1723809at2759"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003876">
        <property type="term" value="F:AMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.20:FF:000011">
        <property type="entry name" value="AMP deaminase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000035">
        <property type="entry name" value="Probable amp deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.20:FF:000004">
        <property type="entry name" value="Probable amp deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006329">
        <property type="entry name" value="AMPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359:SF4">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19326">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1389"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1441"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1405"/>
            <end position="1414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIO02084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1471" mass="166899" checksum="27976EB0D517FE30" modified="2014-11-26" version="1">MDNEFTYREGSTKPISPELHPGVLFQPALSQNGSTSTVPFSERSGHLRCLHGVPHGGLARELSEMFQVVIDGDDGGVEMRRVHDRIEAALRVRSLYRPLKTHVNSQERENPYMSAPMPSCVTIAQEDGVYQVSDHNVSLFLPIPKWAQYAMDVQRVRLTVGNAGCVNACHHRLGIMQERSRMFFLLNAEMEEGANYHKAGGVFSAARKVDNAVLLAESMDAQELLEGVKEMYRRSPEAPVRLRDGSSSTLRELLGTHGIRSADELTVAGLGWQAEKDAPHHGQIDSADYKSMATLGAELRFSFTALQGCLCEKVLQRVVTRAERPSLTPQAAEYSLTLYGLHSTELSDLAELMRRRLEGPHPRVQYILNISFTESPPFEVVSNCTTVQDQLDNIFLALFKATLAENDPSNSGVVWLLGQVGALQMLHARDGPDCDFNETAPPPDQVQIADKQSGLYYMYYLYANLAVLNSLRRRKGLVPFQLRCTGNKSTGMDDLIGAYILSDVITRATKITDYPVLQYLCGLHRVGLTVSPLCDHMEDIVAYKDHPLPHFLHRCLHITLSTESPLRYHHNPRALIEEYATAQKMFRLSSLDMTELAHNSVLMSSFSPDVKRQWLGGDYQLGVDGNVFEVSHVTNARLAFREDAWELERNMMRDLNFSPPQEVGAGPSCWHYLSNVQEVEYDTVMDNRVRFPRTVLKGPHTDPKTATAAPRVARALDLRHQYIWRPPPPWETAQRHDVETDFQRRTATFNEDEWTYAASDGVFIAYPKSAVHAWPRSLPTLDDFHKHLRELKDICASAEVKEYAHKRLENLDHKFRLHLALNHENEAGTTEDRQSSNRDFYQATKVDTHIHMAAGMTPKQILKFVLAKLKESGDDIAMKKGDDIITLGQLFVKAGITPNLTVDQLNVQADHTLFERFDNFNSKYNPMENGDLRSLLLKTDNFMNGRYFAELIHDVFEQYSRDRYTYAENRVSVYGINIKEWDKLANWFATHGMANKHNKWIIQVPRVYKVFRGQNVIGSFGQYLENIFQPLWEASLHPSEHPTLHNFLNHVSGFDSVDNEATIDLPFTTVSPWAWTAVENPPYNYYLYHLYANIRTLNEFRASRGFSTFGLRPHCGESGSEVHLYGAFLCANSICHGINLRNDPPMQYLYYLTQIGLHVSPLSNNALFLYFLSNPFPDFFHRGLNVSLSTDDPMMFHQTQEPLIEEYSIAARVWGLSANDLCEIARNSVLQCGFDNNFKRNAIGDRWFLSSSLGNDSLRTHLSNIRVAFRFETYHTELKQLELCCGRPVARFMMTAAEERVVDAKIVDMRHEYVLLSTHDQAMEVMLREMEDTKEKILQSRTQVEILRRQQRSLLENITEIGIRRQEAEEQAAQEKELLAYKGPLYTRDKSQGSHVGDAGAGRSSIVQSPTCPTHQGEAMKRLLRWKPMPPDLMRSVTQVSVGGSRGRPLPPLPGRQPYPSVTGANGPATY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1W3</accession>
    <name>A0A088S1W3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_350310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the proteasome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702971.1">
        <property type="nucleotide sequence ID" value="XM_010704669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1W3"/>
    <dbReference type="GeneID" id="22579060"/>
    <dbReference type="KEGG" id="lpan:LPMP_350310"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350008200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_350310"/>
    <dbReference type="eggNOG" id="KOG0177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268428at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03758">
        <property type="entry name" value="proteasome_beta_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035206">
        <property type="entry name" value="Proteasome_beta2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 3 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO02171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="206" mass="22922" checksum="B1CC1CD29F0D8D07" modified="2014-11-26" version="1">MAATAIAFRCQGYVMVAAAGLNAFYYIKITDEEDKIMQLDTHQLVACIGENGPRVNFTEYIKCNLSLNRMRQHGRHSSCESTANFMRNSLANALRSREGAYQVNCLFAGYDVPVSEDDDGAAGPQLFYMDYLGTLQAVPFGCHGYGASFVTSLLDRLWRPDLTEQEGLELMQKCCDEVKRRVVISNAHFFVKAVTKNGVEVISAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S233</accession>
    <name>A0A088S233_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin heavy chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_351670</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasmic vesicle membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the clathrin heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703104.1">
        <property type="nucleotide sequence ID" value="XM_010704802.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22579196"/>
    <dbReference type="KEGG" id="lpan:LPMP_351670"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350022700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_351670"/>
    <dbReference type="eggNOG" id="KOG0985">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2113814at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071439">
        <property type="term" value="C:clathrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000001">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000002">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.110">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055358">
        <property type="entry name" value="CHCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015348">
        <property type="entry name" value="Clathrin_H-chain_linker_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016025">
        <property type="entry name" value="Clathrin_H-chain_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016341">
        <property type="entry name" value="Clathrin_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292:SF1">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00637">
        <property type="entry name" value="Clathrin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09268">
        <property type="entry name" value="Clathrin-link"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13838">
        <property type="entry name" value="Clathrin_H_link"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002290">
        <property type="entry name" value="Clathrin_H_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50989">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clathrin heavy chain linker core motif" evidence="9">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="542"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="702"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="849"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="995"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1143"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1291"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1440"/>
            <end position="1583"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1619"/>
            <end position="1646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIO02304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1694" mass="192012" checksum="338E6F61965CD0F0" modified="2014-11-26" version="1">MNSPSLSLEVFQLNSVSGGLRPGSIAFKNVTVESEKYVCVRDVQEDGQTSLVIVDIEKCESIRNNVKDAESCIMNPRSKILALRSGRNLQVFDVEASRRLKATLFHDDVVHWCWIDDRTLGIVTGKAVYHWSLDGAADDAPLHIFDRSADYDGSVQVLSYRSDEQKKWLLVTGVARDPSGAMVGKALLYSVENRSSRVLDGHACCFISTPTPSESRKCNVMCLAWNSPQQGGQVMIMELPTGSKTDLSLPRRIYNLRIQPGDFPVAMHVSDRHKLLTVVTSRGTFALMDIFTGVIVAEQQFTPAVVFRGAGDNKVGGVVCVNNQGSVMRIGPNDSGIINYIKNSMQNPELALRIASTANLGGVDDLFKVQLDNYLRIGNVEEATRICLRAPGNMLRTREILMNFMQMPQQPGQPPAISTYFKIVLAETSLNEYESVELARAVVPKGGIGYVKQQFDEGKLTASEELGDMVQQADPNMALKIFHQGNVHAKVLNVLLQRNETQKAVEYCKRSNFSPDWRVIVNNFIRVAPQDAVNLCLMLYREMGDKPVLSAEEIMDMFVSAQQIQQATEFLLEVLRDHNDESTMDLQTKLLEINLKYSHPSVADKIFVRNICQYYDGMKLAPLCERAGLHQHAIECYMIAQKQDPNLNNLSSIRRCLKQLQSFNPEWLVEFFGKLNKQDSLKCLEDLCTNSRQSFKVLVQVATKYSDALGSTDLIGMFLEHNLYDVLYYYLGAVVPYTRDAEVHFRYIEAAAEMGQMQELERMTRESPCYDAERTKNYLKSKKLTDLWPFINVCDQHNMVNEMVHYLVETSNENYIEQYVTRRSPGKTPQVVQALIECNVSEDFITNMLSVVGTMCPSEELVQCVEETGRLHLIKQWLEDRRSEKKTDKALYNALAKIYVDIGQSPEQFLAENEYYDALVVGRYCETRDPNLAYIAYSHDHCSKELVDLCYRNGMYKQLARYLVKEQDLDLWTSVLAEDTAHRQQLVESVQQTALPESEVSEEVSTTVRAFMNANLTEELTALLSQIVMHGRFRKNRFLENLLIMSAVRSRKDKVMEYVTTLEDYDAADIAHLASGAGMHEVAFVVYTRHNMQKEAIKVLLQDMNDVSRGRAFAQKTDTAAVWSVLGEYLVKQDEVHEGIECLIKAKNPDLVVEVTSAAERTNQYSDLIKYLSMARQYSRAKDSKIDTALVITYAKTGRLGELEEFLKQAHNVKIGAIADKCFDEKLYESARVLYTVANNYARLASTEVMLSNLPNAVEAAKKAKSINTYKEVNLACIEAGDMKLASICAVPVVLKAEEVSGMYNRYESRGMWEELFSVLKIASTHQGAHMSIFTEMGVLLAKYRPEKLIEHVNMYSKKINTHKMITVCEQYHHWIVLRLLHINNEDWLAAANLMMHRHADTFDNEIFKEVISHLGASDVVYTAIGFYLKTHPEHLNDFLSSIFKRVDPERVMEETMRVTPIYVIRAFLETAQERNIKKVNEALNDLYIEEEDFKTLRHSVETYNNFDSEELSSRLEKMELFEFRKIAMLLHRKNKRYAHAIAAAKENKLFDEAIDTAAESADGELVTSLLDYFVKDYPDCFVACLYRCYDLLKPSAVLLKAWLNHRTEVAMPYMIQVLQEYSSKIDRMEKSMVDAQAAAKDAARRAGPMQGPSAAPLMIEQGGGMVMNGMPMSRPPPPMNFGAPLQFGSGRPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S242</accession>
    <name>A0A088S242_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Neurobeachin/beige protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_351770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703114.1">
        <property type="nucleotide sequence ID" value="XM_010704812.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22579206"/>
    <dbReference type="KEGG" id="lpan:LPMP_351770"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350023700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_351770"/>
    <dbReference type="eggNOG" id="KOG1787">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046851">
        <property type="entry name" value="NBCH_WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031570">
        <property type="entry name" value="NBEA/BDCP_DUF4704"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
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        <property type="entry name" value="BEACH DOMAIN-CONTAINING PROTEIN"/>
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    <dbReference type="PANTHER" id="PTHR13743">
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        <property type="entry name" value="PH domain-like"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="6">
        <location>
            <begin position="3460"/>
            <end position="3571"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="5">
        <location>
            <begin position="3618"/>
            <end position="3908"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="4110"/>
            <end position="4142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="551"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="889"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2330"/>
            <end position="2352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2597"/>
            <end position="2626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="3982"/>
            <end position="4043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="564"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="894"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2330"/>
            <end position="2344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="3992"/>
            <end position="4011"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO02314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="4348" mass="468107" checksum="1143E1EB3571CA5A" modified="2014-11-26" version="1">[encoded data, 4348 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S260</accession>
    <name>A0A088S260_LEIPA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_351540</name>
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    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AIO02291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S260"/>
    <dbReference type="GeneID" id="22579183"/>
    <dbReference type="KEGG" id="lpan:LPMP_351540"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350021200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_351540"/>
    <dbReference type="eggNOG" id="ENOG502SBJT">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="H3-Acetyl_Activator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35706:SF1">
        <property type="entry name" value="EMBRYOGENESIS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35706">
        <property type="entry name" value="F14O23.11 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="116"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="174" mass="19259" checksum="65CE9A9B8D8265C0" modified="2014-11-26" version="1">MLSLSISRRSAALMRCRPCFDAVLGARQTVPPLATYIRRPFASSRALVAAAVVSADHTVLHVSKRCEHTTTIETPSGKQLTTKEQVDELMDSFAEACELLTDAKESVGTTYFADDIEDAENQTQDVLKRWESLQADLEHQGAAEQLQRVRSMYELKIKQLKAEFETVREAGGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3H4</accession>
    <name>A0A088S3H4_LEIPA</name>
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        <recommendedName>
            <fullName evidence="4">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3H4"/>
    <dbReference type="GeneID" id="22579689"/>
    <dbReference type="KEGG" id="lpan:LPMP_356610"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350075600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_356610"/>
    <dbReference type="eggNOG" id="ENOG502S27P">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="32938" checksum="D14F5E87C5E04FFC" modified="2014-11-26" version="1">MNREQIARRIDLVGPSTGAIVGVATWCALHGAEADAILNYVAEKMKHKDTTDVVRASLVYVIHELLLSCATHGVSENAKRSTLKAVSLTLPSAVKDTLRQRASDHTAFLIALQKATEWWGMLNLFPAAWLTKLQSTVQEGQEDASHRTTVPSALMQVANLLQRYQHAKEQWVQNRHIKADEGNTSSGIASGQDTASRVASAGAGARGAVVDDAAKRCLIALRKAVESRFERNAALLAWCEAERAELEGRATTSSSGSGVVKMVRGTSSHAPKHDGAGVGYPVKEESGHGDGPSGEAKDEDDVLGSFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3K9</accession>
    <name>A0A088S3K9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Srp40 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_100070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696729.1">
        <property type="nucleotide sequence ID" value="XM_010698427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3K9"/>
    <dbReference type="GeneID" id="22572743"/>
    <dbReference type="KEGG" id="lpan:LPMP_100070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100005900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_100070"/>
    <dbReference type="eggNOG" id="ENOG502S5S9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5599646at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007718">
        <property type="entry name" value="Srp40_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05022">
        <property type="entry name" value="SRP40_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Srp40 C-terminal" evidence="2">
        <location>
            <begin position="181"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="254" mass="28081" checksum="96DA255DB26AA3F6" modified="2014-11-26" version="1">MSHAVDYLVAEYLAEEHPSVARALRKDAPSRFPFGKRNLQEVVMAYCVQKTSPAAVDNNTSYNYGDGAHHPPQKAANTLSPTPIPKPAVEKAQVANSNHDDESVKKPSTKKTSPKVAPNKAAVDTDSSDDTEHVPKNSASGKKPAAPHATEAPARKAARMESEDAAQRTPHHLNENGTFRRFQRIDPTKVTFHADVLRDNRPGEEHLVLRQNQEMMRTKGKGFNKLKQKNKGKFYGAGVDFSVRAYQFPDSDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3Q4</accession>
    <name>A0A088S3Q4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Glycerol-3-phosphate dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="13">1.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">GPD</name>
        <name evidence="16" type="ORF">LPMP_100470</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 13">
            <text>sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Glycosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.8" evidence="13"/>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696769.1">
        <property type="nucleotide sequence ID" value="XM_010698467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3Q4"/>
    <dbReference type="GeneID" id="22572783"/>
    <dbReference type="KEGG" id="lpan:LPMP_100470"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100010900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_100470"/>
    <dbReference type="eggNOG" id="KOG2711">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10263760at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020015">
        <property type="term" value="C:glycosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141152">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000001">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(P)+]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000019">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(P)+]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00394">
        <property type="entry name" value="NAD_Glyc3P_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000940">
        <property type="entry name" value="PRK00094.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000942">
        <property type="entry name" value="PRK00094.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728:SF1">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(+)] 2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0327">Glycosome</keyword>
    <keyword evidence="4 11 12" id="KW-0520">NAD</keyword>
    <keyword evidence="3 12 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal" evidence="14">
        <location>
            <begin position="20"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal" evidence="15">
        <location>
            <begin position="200"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="23"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="275"/>
            <end position="276"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00084116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AIN96116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="367" mass="39398" checksum="5FD176BD0C2490ED" modified="2014-11-26" version="1">MLSANGKVNANELLYLKKAVVFGSGAFGTALATVLAKKCREVCVWHIKEEEAQLVNRKRENMMYLKGVKLASNITFTSNVEQAYKDAEIILFVIPTQFLRGFFQKSGGNLITYAKEKCVPVLVCTKGIERSTLKFPAQIVGEFFADYPLSVLAGPSFAIEVAAGIFTCVGIASADINQARRLQRIMTTGDRTFVCWATTDTIGFEVASAVKNVLAIGSGVANGLGMGFNARAALITRGLLEIRDLTGALGGDGSAVFGLAGLGDLQLTCSSELSRNFTVGKRLGEGTSIEEIQRTSKAVAEGVATAEPLMRLAQQLKVSMPLCKEIYKIVYEKKNPRDAIADLLSCGLQDEGLPALFKKSSATLSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S4I2</accession>
    <name>A0A088S4I2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_354050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703340.1">
        <property type="nucleotide sequence ID" value="XM_010705038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S4I2"/>
    <dbReference type="GeneID" id="22579433"/>
    <dbReference type="KEGG" id="lpan:LPMP_354050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350048500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_354050"/>
    <dbReference type="eggNOG" id="ENOG502RZKT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272581at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="250" mass="28343" checksum="480B9D7DE764186B" modified="2014-11-26" version="1">MEMVRGQVEQVNCRQRKLNEMLESLKAEGLLGGGGTGQCDEQHVETLVERLRARLHSDAASELEVLKTKNSNIQHSLDEVTLAMEKKNSEMEVLRANYARKLARNDVENDTMRAKVQAALHASTLDVERIKRELGRRIDIACASIRTPHYNTSMEAIRELVQQAQEEVQRHHDELTKLVVSIGAKETFLKDEADTMHSNLPSQYRSELRKMEKDQLLNILDVLSFQEGVVDTVGKAIYIITESQHKTAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S646</accession>
    <name>A0A088S646_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA polymerase</fullName>
            <ecNumber evidence="14">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LPMP_161510</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Polymerase alpha in a complex with DNA primase is a replicative polymerase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="14"/>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN97026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697679.1">
        <property type="nucleotide sequence ID" value="XM_010699377.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22573730"/>
    <dbReference type="KEGG" id="lpan:LPMP_161510"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160020500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_161510"/>
    <dbReference type="eggNOG" id="KOG0970">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6755010at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05776">
        <property type="entry name" value="DNA_polB_alpha_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05532">
        <property type="entry name" value="POLBc_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000004">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000003">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000187">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2820:FF:000005">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045846">
        <property type="entry name" value="POLBc_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861:SF1">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 14" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14 18" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="17">
        <location>
            <begin position="371"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="16">
        <location>
            <begin position="680"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00054627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AIN97026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1341" mass="151740" checksum="959723DD93CE9D57" modified="2014-11-26" version="1">MHMSGGHDDASWRLSRKPNTPNFDESQEDQWRSLREEVFQSDEDEDTPESGDLAIPQLPSAKKIVRKLRKLPAAAKPTSKPKQQTLAQSMNDVDMDRLLKRYRIDENVDVTEDIDVSLLLQHHSDSDDDDKEQGVTLTANEFLERLTRAEATPTANLVKVKCELGEKATVVALEDESFSFEKHPSAKPFRSRPTPAESDGAGYRNEETPKQAIELAARLTPQTEAVQLVLPAVSYKSEEMAEGLFYWFDAREQPHTLSVDPGSLFLFGKMVMEKNGRTSYPSCCVRVRNMYRSIFLLPREGSLQEDVVKEINDICRNQGIEQRRIKFVERYYAFEEPGVPYEKTRWAKLRYPGRYPPLNAKGPLRHIQTIMGASSSLLELFLIKRKLKGPSFLRISGLAASASHISHCTLEFSVDSPKNLRVEVAKLPAPPFTLASIQIHAQLDDKGASNEIFIASIAIYKDVNIDNTIRHIPDRILTGVRPASMHVPLPIDLENYCNAKGLPGVRRFANERALLDWLAEQLGNIDADIMIGHNFLGFTLDTLLRRYQELSVSSWSTIGRLDLKRLPRFQGTATNVNQEKETCIGRLVVDSYSLSREHYRTVNYRLLSLAHQMQLQGITKGTNSFEPGTSVLTPAMLSSSRDIYDVLLQVCNCAVLSTAVVSHLDVIRLTKRLTTIAGNLWSRTLFGARSERIEYLLLHTFHDLKFITPDRYVQDFKRGRDDDEEDGKRKAKYQGGMVLDPKCGLYSDYILLLDFNSLYPSLIQEFNICFTTVDRENRSEIDVPPPENLICASCAAAGLSAPCLHKCVLPKVIKSLVDSRREVKRLMKTEKDANNLALLEIRQKALKLTANSMYGCLGFEYSRFHAQPLAELVTRQGRLALQSTVDLIPQLNPSLRVIYGDTDSVMIQTGIKNDIKAVRDLGLDLKAKINKRYQSLEIDIDGVFRAILLLKKKKYAALTVTDWQDEGKTYKKEVKGLDMVRRDWCPLSKRVSDSVLSRVLNAEGSEDILDYVMNYMRDVAGQVRNGCYTLDDFVISKSLTKEPEAYRGNSFPHATVALRMKQRKELVRVGDLIPYVICTGDRLSDKAFHVEEVRQNSELHIDSEWYLSAQIYPPVMRLCEHIQGFSNVQLSEAMGIACHTGPKLEEEEADMMNDFSHSSLFQSRNLEECFPTALPLQVVCTHCRLMTPINPHTRVMEVLSDAESQRDRFNLYVCVSCRKSLPVDYVANCFTQTCYGIIRQFYQCGGGAAAVKAVRTQFTYYRALFDVPHAPGCPARVKDAHYYQARRCLGVDRRLYTLAEAADPAVREVADPVDPLNAAAETIYKRIDHLFVNLDSLFANI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S6C9</accession>
    <name>A0A088S6C9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_170730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697764.1">
        <property type="nucleotide sequence ID" value="XM_010699462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S6C9"/>
    <dbReference type="GeneID" id="22573816"/>
    <dbReference type="KEGG" id="lpan:LPMP_170730"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170013300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_170730"/>
    <dbReference type="eggNOG" id="KOG2793">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="413520at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF97">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="474" mass="51790" checksum="AD64573157C17522" modified="2014-11-26" version="1">MLAWVMKEVESPYGDIATLHWAVPDADADALNSTSLQVELESAEDQLGAVLWNSNTAALRHLHARVFKLPPSSSSSATQAPPPIPLAGKNIVELGAGVGCLGIALAMAGARVTITDLKELLPLMEYNVRLNEKRVQERSRGVGHCAALQWKWGPTMSTMVHKQLQKEKLAVKITDVQQQQHMSPRGVATPPTTSALSNSVDRVVSSMVSSLLPPSASLVECEKALRSAAAGSSSTTATSLKTPFHYVILCDALYGNPKDWPALLYTLTELLATNPDECEVVNFCEQRVKDVEGAFLKLLDEENEKTFVPMEHRLRDGDALWTQAIVSATRCCRPLSTSAAVQQKQREDAANSLLRYVLVQRRGAYRWTYTTNVLQDAQSELNMVIRVTRIRWTRAGVVQEDKAKQQHTGSVGHHATASSTLFGVLEPSRRRRHRGDGIGEDDFATATDAQTPSEGVALSISNKKKHRTGGAHDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S7J5</accession>
    <name>A0A088S7J5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ABCC8</name>
        <name evidence="12" type="ORF">LPMP_200690</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698268.1">
        <property type="nucleotide sequence ID" value="XM_010699966.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22574276"/>
    <dbReference type="KEGG" id="lpan:LPMP_200690"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200011100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_200690"/>
    <dbReference type="eggNOG" id="KOG0054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF273">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="127"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="593"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="737"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1451"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1556"/>
            <end position="1574"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="558"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="998"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="1427"/>
            <end position="1708"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1752"/>
            <end position="2074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="648"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="972"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1277"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1911"/>
            <end position="1945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="995"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1307"/>
            <end position="1324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN97561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2074" mass="227135" checksum="27B3366CB48FB7AF" modified="2014-11-26" version="1">MPSKTLTAVEVKASRSRSTFLVHGVLRRIPGYAFFLIHLCFVHILWGQLVDQLFNSTITFTSTNITKTDLVKDAFIRVWNGICRSVDQTLLHGLVDVLKTSGGTGTTGALAASREGLAFLWKSPSSMVLFFGLAFISLNSVLAALRLFTGFLSSLTALCRSRRQLVRSGSRKPVPLHITVRYGNGYDSVLRLVLAAVELTWFMSYPGLNSAATVKSTADKTRRAPGVAEPTYASLRQLQMRQQAIASFQIEASLLLPPQLFDSTADAIAAGVLVIIFVKVVLGVIVALDAQRLFHALVGVRPLFIPNGWERCPVCGALWKRSREAANAAHLCPNIFTATPLLAGCSPGATASDSEVEDMREQAPGRMRRDVSDCRRIGLPTEATHRPGDAFPDPNKTSFASLATDSWVSPLLNFTLLSPLNTFSPPRLSSIIDDGRDHWRALLRVVDRLPRLPRSLWTRDRIDEPGWVLWQRRHELPFRREEGWLERSFITITGPIRRVLSRAFAVFFLPPSSRGAGTRQDEFGTVRRGSSLFRVFLRHPSGRQFVFTCVPLKLTHDLLSLLAPRVVKSLVAFLKEVSVSNTSVRQSYLGRGLLICLSLILVLSLQALFFQLYLTHLYVACLKSASALKTLLLRQSLATPLAYTGGGRRAMSLRTPDRLQSSSRQSENNRKGKEASSLPTVKPAAEEVTTTTTASLSREGEVMSLITVDITNCSDCLIFLHNVWGHPFVIISSLMSMHTYVGLFSTLATFAALIALIPLNRSSAARVRIAQQQAKNNESRLSDLTAAFSSMRTVKSMALEECLVGRVEEARVRESDGTKCVGRAESVAAAQTEVTTLLVALVCCGSYLLTGGAMDAAVLVPTMAALQVMRFPVWTLPQLYSQVSRGYTSMQRIERFLSEHEVGENASAAYVEHLLRQHNGKGAAREVLPSVTVPVRVGEVRCERGTFAWNTQAAVADQMAFDSALYYSSKQSPKRRLRSPGTACKESDRRVEGDATSSPTHNTYRSPLDNGSRTVVLHDIDLDILPGEFVVLHGPTGCGKSALLLSMLGELYVVPNDNHVASARSTTATPSETRVLPDCQGFQVGGRVVYCAEVPWLRQGTMRENIRLLSDDVPESATEREWYNRVVEACALKSDIEALAKGDRTMVGEGGSKLSGGQRARVALARAVYRYSETDVFIFDDVLSALDVEVQKHIIAYLFHGLLCAAGESSPAPQRRTKTVVLATHAAVSLLMPNRVFHLRPDGTLHEDMTHQALTEDQVHQRKSAWRNATAAAAMEQRRTIHHQAAGAEAADSSTYQNNPTPPLFTKPNQVTEASRKSSAMSSVQTPAAGIDSLLPRASDLHRLFIEYIGGGRFLCFFVLSVSMQLFRTLMDNWLGVYISLYDKRNAAYETILRSTKSQRARKFMLDMLSLVVRRGDKSTPAPAPPSPVVPVLTMFGVPVLWRNPFVLDTVVAQFLGTYAFIGFSAALLSMIRTDYFFRSYQRMADALQLHAVRKLFKAPVSYFDRIPSSRLLQILSRDQEVVDRALSETIQLIFLTVLQLLGMVCFNAIHFGPFIAVLPISALLFYHLTVRFLSFSKQVRALEGVLQSRSVAVMRDAVNGAITIRAFGSVLKDQLVQEMNEALDAVHVAAHAGLTADRWVALRLEFVAVTLTSVLALLSVLTVCLSATTSAGSAAFAGLGIISSMTASRSLSMLCRRFGMFQNQFVSAEQLLRLEEEVPTDAPAVAEGRSEEEASALELRAASEPDTNLLLDVRHLCAKYQPQLPWVLKDICFTLHAGECVGLIGRTGNGKSSLFNALLGLMDVVEGEIRIPGALFSSSPQPKAQLNALHLPQHELRKNYFQLVSQEPLLLQGTCRSNLVLGFRGDSAAPREASGESWVTADAEALDARLSAVLRKVALDELLEPPYAAPVSGQSAVTGADGEVASSATQDAEESASDTIASPSGTVDAATRALDHVVTAGGTNLSAGQRQMLCLARAILHRPRVVLLDEVSSRVDRRTDDLIQRVIKEEMLGRDGEGDDNGNAVKSGVLLIAHRLETILSLCDSVIVIEKGRCVAHLSKEEVKCLEDLESYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S7K0</accession>
    <name>A0A088S7K0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_200740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698273.1">
        <property type="nucleotide sequence ID" value="XM_010699971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S7K0"/>
    <dbReference type="GeneID" id="22574281"/>
    <dbReference type="KEGG" id="lpan:LPMP_200740"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_200740"/>
    <dbReference type="eggNOG" id="ENOG502S6CX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272469at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="816" mass="89534" checksum="C2EE61550C0ED213" modified="2014-11-26" version="1">MFQKRAVMLLSAQWRPHSEQLKLWIIGSASDVTTLSLARDYVNNLDVGSVLQTFEDGLELTGILPVIKYPLGTHTFSKLSAHFEASAGELSASELHQLASSISLSPENLDYYDATLSTPGVIAAIRCCLQRADNSELIAFARPFWQRCEQALQVSTGLASLVTQITADELAFRLSTSSDKATFFDITLMEGLPLEQKGMEGLVKHLQSATEELEKADLLDLLERIAAPRNSQRYATWGMAVQKALIEKGGVTDANCFEVFVKLMLTGTIIDDSICRQICKASVCIGSERTLEVLNAWRDSNSTTCSGSTSLEDVQAALQRHIRVQLEQSQPETSTVEYLEWVLCLSFFSQTDASSLLSRAVTSGRLSGELSAKETAVVCDVMISTCVIPHSLLSAIRRSVESNELSQRASVHALYILQRSGIKASPTLIKRAIGRAGARLVAACTLKKSVDDELFPRDRALLVAGLCFVDDEQQPVLLRRIVESQEVSLSAAMCFLRHAGQATTNSSRWVRKTALSRVLRSASSCSAEELSLVLSALSDLGVRDATAFQRVLEELKRKAPRTEDVVVAAKAARNLRLTSLLEQSELIESLSHIASVSSDDLLVLLSCCTAKQRQALLLFPDVTAALNQISLADSTTSDLVLLFTFLSSQDGKRAEVVAELQTREPVERGALSADDVLAAFESVDSSQEVENLGRVLIRAVQNCGESHLMRLLRCASRYSKVPKTFFRLAGKPIISAANEKRLSPVNASAWLNFYVNNQIRDDSVGRSLLSLLSRAQSRSPSPFYQDYCRGARFYGVNVKKTSRRKQLSDFSLLSPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S8C1</accession>
    <name>A0A088S8C1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Phosphomannomutase-like protein</fullName>
            <ecNumber evidence="15">5.4.2.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LPMP_203510</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.10" evidence="15"/>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698553.1">
        <property type="nucleotide sequence ID" value="XM_010700251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S8C1"/>
    <dbReference type="GeneID" id="22574562"/>
    <dbReference type="KEGG" id="lpan:LPMP_203510"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200041400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_203510"/>
    <dbReference type="eggNOG" id="KOG1220">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8300170at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008966">
        <property type="term" value="F:phosphoglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008973">
        <property type="term" value="F:phosphopentomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05799">
        <property type="entry name" value="PGM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000035">
        <property type="entry name" value="Pgm3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45745:SF1">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45745">
        <property type="entry name" value="PHOSPHOMANNOMUTASE 45A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="9 15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="12">
        <location>
            <begin position="43"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="13">
        <location>
            <begin position="210"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="14">
        <location>
            <begin position="327"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AIN97846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="593" mass="65543" checksum="4090CE5AAAAAC2EC" modified="2014-11-26" version="1">MSSLDAKVQQWLAWDRDPTTCQVIESLAAKKETAELRRRLERRMKFDTAGLRSTMGAGNAYMNSLTVLQTAQGLAAYMKQQFSPTELLRGIVIGYDGRHHSRKFGEITATVMHQQGIKTYLYAHCVPTPFVPYGIGFLKALAGVMVTASHNPKEYNGLKVYWTNGAQIVAPLDASIAAFIKANRTPLESSWAPFTATDHVDPYDAVFEDYFTTLRSSYVPASDASAVRFTFTAMHGVGTRFTTYGLQHVLGLPASHLSVVAEQAEPNPDFPTVRFPNPEEGRSVFALSFATAERHGASVVLANDPDADRLGVAERLSDGEGWHVLTGNEIGALLGWWAMERARWKGIALDHCLLMSTVVSSCILKTMTLKEGAQYSETLTGFKFIGNKAMERRAREGLQTLFAYEEAIGFMWGDRVMDKDGVTAAVVVADLACYLRKERHCSLLEHLQSLYRQYGYHFTYNSYVTTDDPAKTALLLQSIRTAVSGKYPTHVAGRPVTRVVDYAAQVDTAAPLGRPSLGKTSMITLHVDGGMQITIRGSGTEPKIKWYAELVTKDAAGQQTLNAFVVKAIHQLMQPHKFDLVMRSEDAELFSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S9C0</accession>
    <name>A0A088S9C0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flagellar attachment zone protein 1 conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_211420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98221.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698928.1">
        <property type="nucleotide sequence ID" value="XM_010700626.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22574964"/>
    <dbReference type="KEGG" id="lpan:LPMP_211420"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210018800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_211420"/>
    <dbReference type="eggNOG" id="ENOG502SB85">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267039at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005540">
        <property type="term" value="F:hyaluronic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056614">
        <property type="entry name" value="FAZ1_cons"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026203">
        <property type="entry name" value="IHABP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18956">
        <property type="entry name" value="HYALURONAN MEDIATED MOTILITY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18956:SF6">
        <property type="entry name" value="HYALURONAN MEDIATED MOTILITY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23398">
        <property type="entry name" value="FAZ1_cons"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98221.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1364" mass="147646" checksum="229459EC80267C1A" modified="2026-01-28" version="2">MEEDNQRLVKLYEERTSDIAALRVLAQERKYKDAVFTSMEAKTASMDAFLKELMSLTCTGRSLRIRKDANSTQSTAAKPSTARTPPTVVSMDEVRDAVQKQQHALEAAQKNGEEQRLVIQALENEVASLKQKGRSPSTRLQAQKRCLTKPGNATADEDCCLPGTAKALRDAQRRIRELERQLTSTRCEAKNAAAAVASLQQQCTVHLQALKCRDDELAAMRNVLDSKEQLISTLESELRKQRSTSDVLQIEQERTSQHDDHCGRPNSAPAVARHRSGGDEASSGRLVVTHHYHLFGGQAFVDSHSFSPESFKDAFLRSVSTLLKVPYGYLRSVEVRTHSEAVSVEFDVRHSACIREDEINFSLLSHGYPELATFLDKTKAELATRKPLDCNAVRVKELEATLAERVAEVDNLRRAMRSLEASLHRRDADREVLDTDIDAALCETELTVKEVYEALQAMQQEAQDLQKALAVKTSQLRVLERAKAVALDAATAAEEQLKTDRATHHEQLATAQAAVEQAREAAMQEALQRHTNEKVELLMNTFHFDMALPTASAQRTVSHLLKEAQRTRVLQALLLCHAARTAGAVPVVAKKCSLGDDAATLKVTVELAFYASKKDADAVKTDITKKLSEDSCSAVYEYVRMLSDASKREAETVADAQRAVSEAEQRATAAIAAMQAETQQTQNTQRAATSKQLREIHARVSSILPGGSADVKSILERIDQLALRLATAESTTHRLEEDSHRAAQRFMDAQQEREQLQQTLSNLTGHCTELRIAKEQLTARVAAAESQLRNQQVSAAESESALVEKVRHLEASLRAKADATDSERDRLLEEHRTAATLAAARLAEVEEALAIKETALTQLQSTTASSGSGAASSGSVEETALREALRLAKQERTALARQVREMDMDMNDLSNIQAAMQRELEVTQQELRAKKHDFDLLVKQLIRMEEKEKKWTSDHPASPVSPKKQDEDTELDDVARESLIVLTNSNIILQQCLRRLQCTTAAMGMAASLSSSSATDGTDAVAGTAAGRGGERDGVRIGDDSSGTRRSGHRKSALGATVSRTAMNHQKLSAQLADMLLRVLQEVETSMSSGTASRSCGRRGPATATAAVADAAATNLRVATQRRSAKHSPMSIHFSRTASTPAAIGSEKCGQTFNGSFTSPRDAAIASRNNTPKRGTVSDAALSTVATGSGGKAIMDAAPRLDFHRQGSSRTYTRSNTATSVPVNADSAELLPVAAASDSASPDANFDSSGAATRGSGGERKEEKGKEELPRGVSGSGGAATAGGALNNASPTKAPPTIRRNEAPTATTKANPLRRTNATATTSGGSAIGTSFVHTGCGYRRLPMVTESNAPTTSLAKRTRPPQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S9W6</accession>
    <name>A0A088S9W6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mitochondrial glycoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_221360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699138.1">
        <property type="nucleotide sequence ID" value="XM_010700836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S9W6"/>
    <dbReference type="GeneID" id="22575182"/>
    <dbReference type="KEGG" id="lpan:LPMP_221360"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000018100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_221360"/>
    <dbReference type="eggNOG" id="ENOG502QWP2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="278212at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.280.10:FF:000014">
        <property type="entry name" value="Mitochondrial glycoprotein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.280.10">
        <property type="entry name" value="Mitochondrial glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003428">
        <property type="entry name" value="MAM33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036561">
        <property type="entry name" value="MAM33_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826">
        <property type="entry name" value="COMPLEMENT COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826:SF6">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02330">
        <property type="entry name" value="MAM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54529">
        <property type="entry name" value="Mitochondrial glycoprotein MAM33-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="248" mass="28874" checksum="9FD9B62DF000B8AA" modified="2014-11-26" version="1">MSGFRVSFGDTLRNAAAGKADLPARSEPRRHRKLYQLTMREEREEGIRDFLPPRPLLPLGWKLQHESGSNRFDLFKNVEIRQCGSEELHIITLMETKEYEGTYRMDNGEREEQEYLNFGLFMRKKRYPTGGLEFSLTSIDLELVMDGLTIHPSEEAFENAKSCYGRNYTAAAKKDACITTGDARRRRASKYAGPMLSELDDDLSDEILDYLDERGVNNAFAEFVMDQAFYFEQEEYINWLRLLRKFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S9Z7</accession>
    <name>A0A088S9Z7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="1">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CYP3</name>
        <name evidence="5" type="ORF">LPMP_230140</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.2.1.8" evidence="1"/>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699173.1">
        <property type="nucleotide sequence ID" value="XM_010700871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S9Z7"/>
    <dbReference type="GeneID" id="22575218"/>
    <dbReference type="KEGG" id="lpan:LPMP_230140"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230006300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_230140"/>
    <dbReference type="eggNOG" id="KOG0881">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271386at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="4">
        <location>
            <begin position="27"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN98466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="192" mass="20511" checksum="4B2D0DB3E17FD4C1" modified="2014-11-26" version="1">MEKAARVVQLQSTAGALSFELYSNFCADSFWQLASSGQLRRLVFRQLLCGFALLGEVEAVQGHSATASEVDAAAESPDGLSLLHVGAGLLTCSPTVGAVTASRFLITLSPQPQLDKTHVIFGRVYSGIQTLERMSHMQVDADFVLYSPVTVIKWSSAALLRGSAPRSSACKGESEPYTVTLQSRSSILATLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SBF1</accession>
    <name>A0A088SBF1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_251330</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699703.1">
        <property type="nucleotide sequence ID" value="XM_010701401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SBF1"/>
    <dbReference type="GeneID" id="22575781"/>
    <dbReference type="KEGG" id="lpan:LPMP_251330"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250019000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_251330"/>
    <dbReference type="eggNOG" id="KOG3497">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10258858at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000024">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00250">
        <property type="entry name" value="RNApol_arch_Rpo10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023580">
        <property type="entry name" value="RNA_pol_su_RPB10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000268">
        <property type="entry name" value="RPABC5/Rpb10"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003089">
        <property type="entry name" value="PRK04016.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431:SF3">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01194">
        <property type="entry name" value="RNA_pol_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46924">
        <property type="entry name" value="RNA polymerase subunit RPB10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN98996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="84" mass="9731" checksum="6F9161DB5860C8F9" modified="2014-11-26" version="1">MIIPVRCYSCGKVVGNLYEQYQRLLDQDYTESEALDALHLDRYCCRRMILSHIDLIDDLIPYSVPVAGTMQVMGPLRMSSPHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SBI1</accession>
    <name>A0A088SBI1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_251680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699738.1">
        <property type="nucleotide sequence ID" value="XM_010701436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SBI1"/>
    <dbReference type="GeneID" id="22575816"/>
    <dbReference type="KEGG" id="lpan:LPMP_251680"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000047900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_251680"/>
    <dbReference type="eggNOG" id="ENOG502S0CK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="274829at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="145" mass="16735" checksum="A7B8F268457E5193" modified="2014-11-26" version="1">MVLFSTYRSKRIVAQGFLSGPVMTARAFGDYYFQRAWNGCVQWVIPGEMRFWACGIPIIYFIHRYHNDHSLEPDLVEKAMILRWGGSLEEVRKLSPQDQLRIRIFTDIEKLYSAYGPKDTIIQPPGDTLPGKDYYHKSGTPGAHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SC39</accession>
    <name>A0A088SC39_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WWE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_261380</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699958.1">
        <property type="nucleotide sequence ID" value="XM_010701656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SC39"/>
    <dbReference type="GeneID" id="22576041"/>
    <dbReference type="KEGG" id="lpan:LPMP_261380"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260018800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_261380"/>
    <dbReference type="eggNOG" id="KOG0286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052234">
        <property type="entry name" value="U5_snRNP_Component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004170">
        <property type="entry name" value="WWE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037197">
        <property type="entry name" value="WWE_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006:SF1">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02825">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117839">
        <property type="entry name" value="WWE domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50918">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WWE" evidence="6">
        <location>
            <begin position="105"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="375"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="461"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="546"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="201"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN99251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="585" mass="63351" checksum="90C865C79659B3C6" modified="2014-11-26" version="1">MGAGNISKHSRGGGTLSTTGGVPGAAATKATTNPRDQVDAPKSAAPSGAAAAARTKPDAVVSYKKGDMLRVIVRLLKPGETLPQEVGRVMEGAPISGHDIPPPPQQQQETSKEETTFGWFVEDLERPGTWEPYTKESADRLEDAFLSMRDTCTVVMKKRSYIVDLQTMQQRPAASAGTANTYSAQQQRTREVKRAPVVTYTDPNTGELKTREAPPKMLDPFAEDEEDGNDQQPQNISEGDGDVVGGGDGTGEATVAAVARDGRLPHLIRTVIPHTASIYTMECTPDVQQLCPEARAVVEPTGGPLILSGGRDVQLLEWSIQTSTVVTRYELPRVSPKNSVLTANYSSTAKWIIAGLDDYTARLYAIGKPNEVYRLEGHSHKVYGAGALAGDSQVATASMDSRVKLWDIATGDCVRTVVPHNSYIFALRSHLTDPNIALTAGEDRRVCMHDFRQENSVVAAFTGHERTIWDLDWNPVNTTFAACGMDSTTRIFDPRVNNVALVTLRSHSRPVHSIKYTPQGRGLLSCSKDSFVSMTDTANWTVQWQTKAHPSTVFRVRCCAGKSVIVTGGSDACVNVWSWGALAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SCH0</accession>
    <name>A0A088SCH0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transmembrane transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_270210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700108.1">
        <property type="nucleotide sequence ID" value="XM_010701806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SCH0"/>
    <dbReference type="GeneID" id="22576197"/>
    <dbReference type="KEGG" id="lpan:LPMP_270210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270007600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_270210"/>
    <dbReference type="eggNOG" id="KOG4473">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="73465at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02434">
        <property type="entry name" value="Nodulin-21_like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="FE(2+)/MN(2+) TRANSPORTER PCL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN99401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="289" mass="30998" checksum="894B4C66DAA9DE45" modified="2014-11-26" version="1">MSESAALNASAAVNLDYKSCDAARAAFRAGDVEASRREHMKPMHIESHNSSASEYVKSVVFGGLDGIMTTFAIIAAAAGSGGNYATVLIFGFSNVIADGFAMGFGEYVSGEAERENAVSERHREEWEVENSFDLEVDEMVQIYMAKGLSFDDAQTIVSIISKDPKMFVDFMMVEELGLLVDLDDAYGPMKQGVVMFISFVLFGSIPLLAYLPGKGQGTDLVFFVSCFLTMASLVFLGSVKGYLVGVRMGRSAVLMVLNGIISGIFSFLAGHLIQVALTTEVNASSSISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SD82</accession>
    <name>A0A088SD82_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_280300</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the BCD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700373.1">
        <property type="nucleotide sequence ID" value="XM_010702071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SD82"/>
    <dbReference type="GeneID" id="22576475"/>
    <dbReference type="KEGG" id="lpan:LPMP_280300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280008400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_280300"/>
    <dbReference type="eggNOG" id="KOG2858">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272357at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070761">
        <property type="term" value="C:pre-snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048254">
        <property type="term" value="P:snoRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23023">
        <property type="entry name" value="zf-HIT_BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051639">
        <property type="entry name" value="BCD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057721">
        <property type="entry name" value="BCD1_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483:SF3">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25790">
        <property type="entry name" value="BCD1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="11">
        <location>
            <begin position="137"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="10">
        <location>
            <begin position="550"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="10">
        <location>
            <begin position="577"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="8">
        <location>
            <begin position="550"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="8">
        <location>
            <begin position="577"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="521"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="633"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="528"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN99666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="662" mass="74102" checksum="BC9201335166E4F4" modified="2014-11-26" version="1">MNRLAALKTRAECNAAPLLDDGSKECEAPHEYMHNSEDTCSSDSDDARESNSGLQHGSSEAIASDDNIDSGNESGKDDGGDDVGNGQHDDPFFCASRDADEVSANTLSAALLSDLNTSHTPRTPHEERVAQRKTTSCCVCGTRAVYTCPGCGRRTCSMTCVRVHREDFKCTGVRDMAAKIPLSEFTDQQLQRDYHFLENCRRVIGNIERCFPRMSWRYTYKALPPPLHALRDAARRRGVICQITSEGMRKRDENTSRLDRKTNTIVWRCEFQFSSADDEAEWTTISTDWGSERHRLGDVLKYCWATNPPLLCYHINRRYNGATKYVGGSATKTAKSIGDEVFDETNPTQRDSAAVPQKTVVREASAGAQPTGAHALPTTEVARVAGDEVECNVAPLTVAAVESEAADSTEECPVNAPAEPLPLRAYEEVPPTPPIEPITPQEAQQQAFVQAFLAQEYFILSKAERLGNDARYFLLDPYDTLNENLRRLFFINEFPVFVVVHASQLHRFTLVTEEDKEAIRSSFRSKKAHEPHERPRMRKRSEMEPEEVERLSRVPCRRFLQGRCLLAEDCPYWHCTPSEIPVCRTFLRAGQCDKGARCSFRHDADAVRIARKRQRDGLSEDGRPIRGRCVGRGRGFNRWRDGGRGHSGMGGSGSYPPRPRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SDS4</accession>
    <name>A0A088SDS4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_282790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700618.1">
        <property type="nucleotide sequence ID" value="XM_010702316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SDS4"/>
    <dbReference type="GeneID" id="22576724"/>
    <dbReference type="KEGG" id="lpan:LPMP_282790"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280034400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_282790"/>
    <dbReference type="eggNOG" id="ENOG502SMRN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="263077at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="473" mass="49044" checksum="0D1750225DDD09DA" modified="2014-11-26" version="1">MSRPRGDSGYDPLPGSQCEASPPLAVLLCRSQRSPSTPLRVFGSEITNRLPTPPPPRISSSSPLTAAAPLCAATATLCSVAIDAPLSYAPPGPASSSSWLEVDPYCCPSNRGDVVEPSLSYETLLGAKGSACPRQGPFPLAGVGSRSSGNSTNSRVTLQTVGGGDQSCLELPHGSMSGQAETSMPSALSAKRRLRDGGTENSDGHAGPRSSWPHVKRQRGEEAANSGLTGAFSATAPLPRLPAPPMRTGGVGVPGGADSICCGGDVDARLSLVTSSSEYDGDPWGPRRGACGFLTPVSTKLLSLPPVALVPLPPSQHLHARVCRPASLLDKEHAAPAWQVLTSGPAATEEEEEGLVHLVSTSRSTTLFSPARGNVLLCNAVDGAISYSPLTLDDISPILCLSEERLEHCRMSAVACDRHSSAEVDDEESMGGVAPDLSTQCFTGSARFVHEEALRLLTATCEDAEGALLQWPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SED4</accession>
    <name>A0A088SED4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thiolester hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_291740</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700779.1">
        <property type="nucleotide sequence ID" value="XM_010702477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SED4"/>
    <dbReference type="GeneID" id="22576937"/>
    <dbReference type="KEGG" id="lpan:LPMP_291740"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290021600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_291740"/>
    <dbReference type="eggNOG" id="ENOG502S2P3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="331699at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052816">
        <property type="term" value="F:long-chain fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03442">
        <property type="entry name" value="BFIT_BACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000116">
        <property type="entry name" value="Thioesterase superfamily, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040170">
        <property type="entry name" value="Cytosol_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11049">
        <property type="entry name" value="ACYL COENZYME A THIOESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11049:SF24">
        <property type="entry name" value="CYTOSOLIC ACYL COENZYME A THIOESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="HotDog ACOT-type" evidence="3">
        <location>
            <begin position="159"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO00122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="339" mass="38082" checksum="34D6247ACC9F1C4E" modified="2014-11-26" version="1">MLDLCAARTSQKALDHQTCLTHERYLTCTVGVTNTMFSSPILHGDAVRLDGRLVHCGSSSMGIYIRFYRQSPSTRTETPAGESFFTMVAITPDLKAAKVVPAMELTDPFDIELHNRYTKILQIQAENAKNTAERLKRILTTEEAQCSINEQKPIHVRINSTKVEANRIFFTSCMNNNNTVFGGELMAWMEQHAVHCGRMFTGNRHVFTIGMHSVAFPEPVFATDWVTLEATVIYVRNTTMEVDVVLKAERKDTSTVITNRASFLLINNDDIGRKCSIPIGLVLNGATQEELQRFMEARVRNRCSVAHRDAFYGANSRTGTTNLQVDKKGEGKRVGKREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SFW3</accession>
    <name>A0A088SFW3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amino acid permease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">AAP13.1</name>
        <name evidence="5" type="ORF">LPMP_310840</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00672.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701472.1">
        <property type="nucleotide sequence ID" value="XM_010703170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SFW3"/>
    <dbReference type="GeneID" id="22577510"/>
    <dbReference type="KEGG" id="lpan:LPMP_310840"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000030300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_310840"/>
    <dbReference type="eggNOG" id="KOG1305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28208at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF702">
        <property type="entry name" value="AMINO ACID TRANSPORTER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO00672.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="479" mass="52286" checksum="F604CC33CD319CFA" modified="2026-01-28" version="2">MSKPNQPIQAQVEDNALNGSLTDGNSSNTGGVDLSDGQVKRPLHSGSPTESTGHHNDSDVQKRQPNIIFRFTEWLIPYGGVVSNCFSLGSVTLGGGIISMPSSFAMSGIIMSVIYLVVVTAATVYTMTLLGYAMKATGCETFEELARVLFGRGWDYFVGFVLWLSCFGTAVAYISAVSSLISPILEKSPGTPAFLLTTAGNRCITSLIWLVLMVPVVIPKRVNSIRYVSAIGVTMVLYFVVVIVVHSSTNGMREGLRGDMKYFTTGNQAVYGLSIFVFSFLCQAVTGSVYFEQRPQPSVRQLTIASAIAMTVCMVLYIFTGVFGYFDFGDDTKDSVLYNLDPVHNPYVMVAYVGMLIKICAAFAMNMLPCRNFTYHCLGWDLDTVPYWKHTIVILSTAVVTLVCGLFIPSINTALGLVGSLCGGFIGFIFPAYFWMYAGNWSLKSVGIWHYLGTYFLLISGVIAIVFGTISTVYFSFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SG28</accession>
    <name>A0A088SG28_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleosome assembly protein-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_311670</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701557.1">
        <property type="nucleotide sequence ID" value="XM_010703255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SG28"/>
    <dbReference type="GeneID" id="22577593"/>
    <dbReference type="KEGG" id="lpan:LPMP_311670"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310023000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_311670"/>
    <dbReference type="eggNOG" id="KOG1507">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27325at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="333"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="49"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="277"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="337"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO00757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="407" mass="45506" checksum="F96439FA0020823A" modified="2014-11-26" version="1">MPSQVHVDPMARAASDASETSSSEVDMVAVMMEMTVAERRRVYALQGLLKEYYDVRKRMRTEIAALANECAAANQKLFAARKEIVTGARDITAEEMQRIGFTETPIAPEKDAAPAKKGVKLVDPVDEKQNNALVEAAASPSGGIPAFWLTAMSNSEAVSNMITEKDRDALMHLADIEHGFVEGDPEKGDRLIFHFSPNEYFTNETLTKEYRTEYDEDHGEPRITTVVGCDINWKSSKKNLTVTVKQKKQRNKKTGQMRVVEREEPCESFFNFFSPPDPDDDEDDDDTDEDFLEQEMEMDVEVGTALTQAVVPRAIFYYTGEAVVETGKELREQFGFGEEDDEETDKDEDDDEDDDEDDNGDEDEEAASASKFRNIVRQRGGGAAFGRRDGGNTAAGQKPPQQECKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SHK8</accession>
    <name>A0A088SHK8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_330240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702117.1">
        <property type="nucleotide sequence ID" value="XM_010703815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SHK8"/>
    <dbReference type="GeneID" id="22578177"/>
    <dbReference type="KEGG" id="lpan:LPMP_330240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330007200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_330240"/>
    <dbReference type="eggNOG" id="ENOG502SKM0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="263665at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="926" mass="100457" checksum="85CCB5B820CA2BB8" modified="2014-11-26" version="1">MSSTGLIVRQLIAWFAGVLPICFYLALAVVCGLHRRWISFAFSVALMLALLVSVVLNCVAIISTILLTRSRTNFAQRVKKIPGETLWDSLYLEGSAPVCANPQIDLFDVDGNETRMISRQSDEAVLSSIRESTTVSLNTVKSQSFSPSVLGSSRASVNPLCPPLHPAAAVRVVPQESVQPRREASVTQLEETFMLSPPSALEHRFMRDRTSAAFTSPPLGPSTPQSYPEERPSADRNLSGSFERSVCERKDNAQQFAAQLYEPLHAPTGVRRTPEASAIPSIHDTNSSKFFCTAFMMPFVSLYMTIILTILTLVGSLMFEYDTHCLFLASPALGVPWLWVNLLPVRNAFQNTSENAQNFHGRLVCALTHWLFMIAISIVSLGVFVAAFMLEVVYWPPYRIDGEATPRSIRVLSYLAPVLVMAIMGIVFSNLESMHSTSGECGESGPLVAEAVPVTTDYRGCPPAQVTTRVLTPGLLPGDCGGEALPFAGLGNLTGTSLTDSVGVVSVAVVCASAQSTVVTPNLAPMSNGEPVATLSSILRSATGGSAFIPLINKTSITMLPRSKGFRHGIQLSSNGSSDLQKGSHPATTMTSVPQLKTVTMLYVAYRDICDGGDSTMASTFKASHQKGSVAASRNQLQAVSVNFEVMMEALEDAREQGSADANAYVLTAYEDAICLVWGLIPFRSDPVLLAIEKAIQIMEAFKSRPKPPPSFSCEQRELVAAVVSVPYSLVGLIGSGAFRSIHFFNPRQHVLGAQMLRRGTAMYCRLPSVQASLDEPENPFHCILLDGRSWSSTASHVLARPCGICRSYGLGADAKQPNQRSSPLNVTTNPTRQEFLITYNFMEMVQAKEEEWHLVVQRQEHLGAKFNFLSEAVQRLHQGDQSGACKVLRDAMQSAASNSDADNITLAQMLLEDLECAEDGGPHDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SHX2</accession>
    <name>A0A088SHX2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aminotransferase, putative</fullName>
            <ecNumber evidence="7">2.6.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_331400</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.15" evidence="7"/>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702232.1">
        <property type="nucleotide sequence ID" value="XM_010703930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SHX2"/>
    <dbReference type="GeneID" id="22578293"/>
    <dbReference type="KEGG" id="lpan:LPMP_331400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330019800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_331400"/>
    <dbReference type="eggNOG" id="KOG0257">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016212">
        <property type="term" value="F:kynurenine-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047945">
        <property type="term" value="F:L-glutamine:pyruvate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000024">
        <property type="entry name" value="Kynurenine--oxoglutarate transaminase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051326">
        <property type="entry name" value="Kynurenine-oxoglutarate_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807:SF20">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="31"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO01432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="414" mass="46414" checksum="F281D93493B9E98D" modified="2014-11-26" version="1">MSKFCPAQRLLGLSTSSVWEEMTPLANKYKAVNLGQGFPKFAPPRFLQEELKKILECSDEAPLAHQYCSPRGDAELITQLCKSYSKLFSQDVQPSNVVVTNGVTQALNAIFQAFINNGDEVVLVEPFYDAYYQDIFITDGVTRYVSLQPSSESADSWKLTREALLEVVNDKTKFILINTPQNVPGKVWDVEELQMIADVAKQFDVVVISDEVYMYLTYGKPHISIALLPGMWERTITLCSAGKTFSCTGWKIGWAVGCDRLIAPIAQIVSYQTFCCSTPFQIALARAMAKAEENGFYDILRDKYAARVNQLSNILTASGLCPVNPNGGFFVLADIKKVDPKHYYDASNKSQAKDWQFCLWLTKRIGVCAIPATAFCSEKSKPLYESYVRFACCKPQCELSTASERLQKLHEYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SI27</accession>
    <name>A0A088SI27_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dual-specificity kinase</fullName>
            <ecNumber evidence="2">2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LPMP_331910</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="2"/>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702282.1">
        <property type="nucleotide sequence ID" value="XM_010703980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SI27"/>
    <dbReference type="GeneID" id="22578344"/>
    <dbReference type="KEGG" id="lpan:LPMP_331910"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330026200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_331910"/>
    <dbReference type="eggNOG" id="KOG0667">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14210">
        <property type="entry name" value="PKc_DYRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.10.30">
        <property type="entry name" value="DYRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042521">
        <property type="entry name" value="DYRK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF22">
        <property type="entry name" value="DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="83"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="393"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="451"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="630"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="708"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="916"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="399"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="467"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="499"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="522"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="639"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="708"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="733"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIO01482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="950" mass="103346" checksum="70B74756A15BF5AF" modified="2014-11-26" version="1">MHPKYGLSTSGASLISASEAMHHFGDCLTAYERKEIVQYEAVYYAGQRCVDKVKSPNNGHNDGYDTEEGEYIFRVKDHIAYRYEVLEELGSGAFGQVFKAIDHFDGSIVAVKLIRNHRKVLQADQEIGILQRVNDRDPKGLYGIVRMIDNFKFRGHICISYELLGANLYEYLKTKDFFPMALPLIRSIAARMLVTLSFLARENIIHCDLKPENILLRDNDPAVVKVADLGSASIDTKSVYVYIQSRFYRAPEVIMEQKYNNAIDWWSFGCILCELANGDPVFPGNDEKDQLGCIMEYLGPPPQNFIEASSARRKREFFDGHYKPRPHTTREGKQRETGSRSLSKFLGVSEDDDFLSFVRLFLQWDPSQRVSPREAMKHRWICDKFVFPTQSEEKKPGLSSLTKESNASASGSLKECMSQEPAAPLKPKVSMSTIVGSLSTAREAPIDSLWPSAGPPKAQRSAPLLQPPTTCTGSANFNTSGDNASRVNTLPPSRDAFSGTVTRGAAQSTGAKFQGASVPQRHNGRLQRGRQRRSTDMADVEIPGEAIALLNNSTSLHAPLGAEESSAEKHSRGLMITANKDSSPVSVRGVVTRVINPRPQLRLAGGVLSPEVLSPVTLHSSANPVIVTSRDRNAHSSENEASPSASHSNTNSGAVGNARGNSSAGDVPTSVLELPQEYEGTTAKTHTVDLLGRNGGAIDFCSLSRWPSTTRTSQLNGDRQRSASASARRDSHGITSPGLSTESARGEAVRERREHLVSLNPVDLSPTKASQPAAIQGRPHAGEYMLPSELPPFREGASSSNLDDVGVSPNCRHLAAILSDPRNKGGLTELSLQTRGSPPLPLPGPSAVAAPSLTPPYRFLQRSAQCNIPVVCDDGAAHTAARNQRVGASEASSMLSERRAVQLSGMHLVPPRQVLGRQSLLPRQNGSGTRGKAVTKPSTVTTPQLPLLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SIA7</accession>
    <name>A0A088SIA7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="11">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_332660</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="11"/>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702357.1">
        <property type="nucleotide sequence ID" value="XM_010704055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SIA7"/>
    <dbReference type="GeneID" id="22578419"/>
    <dbReference type="KEGG" id="lpan:LPMP_332660"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_332660"/>
    <dbReference type="eggNOG" id="KOG0785">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="419183at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004439">
        <property type="entry name" value="Isocitrate_DH_NADP_dimer_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005425">
        <property type="entry name" value="PRK07006.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00183">
        <property type="entry name" value="prok_nadp_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43504">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NADP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43504:SF1">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NADP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0521">NADP</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="12">
        <location>
            <begin position="19"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIO01557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="425" mass="46398" checksum="C8C8774A80125547" modified="2014-11-26" version="1">MAESISFVKGELVVPTHPIIPYIEGEGIGKEITEVAHRVFDAAVAKEYGATRKISWVEVLAGEKAFEKKGTCLPAETIEAFDKYHIGMKGPLGTPVGEGIRSLNVVLRRELDLFVCQRPVRWFTGVGSPIRHPEWVDMVVFRENTEDIYSGIEWAEGTPEVAKFADFLQKEMGVTMVRFPETSAYGVKPVSVEGSERLVRAAVRYAIDHHLPSVTLVHKGNIMKYTEGGFKKWGYALAEREFPEAVFTMTQYDAIKTKSGKEAAETALREATDSGKVVIKDCICDSFLQNTILRPLDYSVIATTNLNGDYVSDQLAALVGGIGISPGANINYTTGHAIFEATHGTAPDIAGQGKANPSSLILSGAMMFDYMGWSEVSARIVNALEMVFQANMATRDLARQMVGAKSLSTADFGDAIIRKINGEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SJZ2</accession>
    <name>A0A088SJZ2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_345030</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702922.1">
        <property type="nucleotide sequence ID" value="XM_010704620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SJZ2"/>
    <dbReference type="GeneID" id="22579008"/>
    <dbReference type="KEGG" id="lpan:LPMP_345030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340058300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_345030"/>
    <dbReference type="eggNOG" id="KOG0589">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="69"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="9">
        <location>
            <begin position="376"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIO02122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="478" mass="54516" checksum="4057C16D6BA36C8E" modified="2014-11-26" version="1">MTAREGEPNSASMELLNQYAKYFPHVLFTSHKAFEKYVASLDPEVYNNCVDLPEGEESLESRNPQEHMYVLTTLVGRNPTTAAFVATRCSVPAEKVVAKFVMLSDERQAAYARSELHCLAACTHFGIVKHFDDFKSDDKLLLIMEYGSGGDLNKQIKQRLKEHLPFQEYEVGLLFYQIVLALDEVHSRCMMHRDLKSANIFLMPTGIIKLGDFGFSKQYSDSVSLDVASSFCGTPYYLAPEVWERKRYSKKADMWSLGVILYELLTLHRPFKGPSQREILQQVLYGKYDPFPCPVSSTMKALLDPLLSKNPADRPTTQQLLHTEFLKYVANLFQDIVRHSETISPNDRTEILKQLQGSGERAPSPSAIRYDVLTSEVTHGGYLYKYSSDMRWKKRYFYIGNGQLRISLSENPENDGVAPKSVNLETVSDAFPVPEVYSQKHPNQLVLWFNNGQKIIAYATTKEDRDVWISKFQRACGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SKT6</accession>
    <name>A0A088SKT6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_352900</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703227.1">
        <property type="nucleotide sequence ID" value="XM_010704925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SKT6"/>
    <dbReference type="GeneID" id="22579319"/>
    <dbReference type="KEGG" id="lpan:LPMP_352900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350036400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_352900"/>
    <dbReference type="eggNOG" id="KOG0922">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000047">
        <property type="entry name" value="Pre-mRNA splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000615">
        <property type="entry name" value="pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000145">
        <property type="entry name" value="probable ATP-dependent RNA helicase DHX40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF85">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="426"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="611"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIO02427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1080" mass="122813" checksum="41BF233DC34194DD" modified="2014-11-26" version="1">MNTGGDDDAVAEQQNMSFLMQLQELYCKTALYEQLEQIMGHPATQEESDGYLDDVEGLVELYCSEREAAKKTAPPAEEADAAAQCEEATKQHILKSLSDAINGVAEADEEPDIPMSSIQQLYHVLHDCLTIDTVETGLAVGSLLLADDAKRSAEEASRLAYQQQQRHMHSGIDTASMTTSTAERKNAMKVSPEEMFRLAQHVRSGLADEAELLKLRSEDNEEEGNGEQDVELNDEEPRFLRNMGFSSMLHRRINYRAPLPSQQLRDARTPQHRQAILDRLAQRQQGDTSKLNSMEKAAQMQEKINMDRRVIARKAQRTQQESREYDFGATMSVRDDRSVLDESRYEWKGRMLESEEYSTQPTLLHSEQNTLPEEGGFRPQDLPTKLAPWMKHSFGRKPRFGLPETLQTIQEQRISLPIYAKKEALLNFVDAHQVTILVGETGSGKTTQIPQYLVEHGYADRGMIACTQPRRVAAETLAMRVAEEYGCRLGEEVGYTVRFRDVTSSLTKIKYMTDGMLLREALLDDSFQRYSVIILDEAHERSISTDLLFAIVRQALRKHEGLKAMVTSATLETEKFCAYFGASEPFRIEGRTFPVETYYLTDPTTDYVRAALQTVMMIHLQEPPGDVLVFFTGQEEIELGGEQLFRWMEMLRRQVSTPLPDLMVLPLTATMPQEVQSKVFESTPPGCRKVVLATNVAETSITITNLYYVVDSGFCKQNIFDAKHGIDQLKVMPVSQAQAKQRSGRAGRIGPGKCYRMYTEKQFTTDMVPETVPDIMRTSLFHVTLQLKAMGLDLLNLELMDCPPKGAIVSALEKLRYLEALDDDGLLTPLGSRMAQLSIDPSQSKTLLTAVDLGCSEPVLTIVSMLAVQKRGVFYRPRDQQEASDAARRQFMQPEGDQLTLMAVYDAWVENGMSEDWSKHNFLKHRMLVEARDTRDQLKEMLARRNQHISHENDTNIDEVRKSITAGYFFNAARRVDSHTRSYVTLSDRREVYVHPSSVLIDDPPKYVLYDDLRMTKREYMTELLAIEPKWLVELAPAFYAKPKEGRLTKEQAAERFTPILKSWETGSSWRISRLKKQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4T3</accession>
    <name>A0AC62A4T3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NADH-dependent fumarate reductase, putative</fullName>
            <ecNumber evidence="1">1.3.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_341060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.3.1.6" evidence="1"/>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="XUY36769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1147" mass="123653" checksum="3164A2D6E9B5FB23" modified="2026-01-28" version="1">MADGKTSASVVAVDPERAAKERDAAARAMLQDGGVSPVGKAQLLKKGLAYAVPYTLKVVVADPKAMEKTTADVEKVLQTAFQVVDTLLNNFNENSEVSRINRMPVGEEHQMSAALKRVMACCQRVYNSSRGAFDPAVGPLVRELREAAREGRTLPAERINALLSKCTLNISFSIDLNRGTIVRKHADAMLDLGGVNKGYGVDYVVEHLNNLGYDDVFFEWGGDVRASGKNPSNQHWVVGIARPPALADIRTVVPQDKQSFIRVVCLNDEAIATSGDYENLVEGPGSKVYSSTFNPTSKSLLEPTETNIAQVSVKCYSCMYADALATAALLKNNPTAVRRMLDNWRYVRDTVTDYTTYSREGERVAKMFEIATEDKEMRAKRIRGSLPARVIIVGGGLAGCSAAIEAVNCGAQVILLEKEAKIGGNSAKATSGINAWGTRAQAKQGVMDGGKFFERDTHRSGKGGHCDPCLVKTLSVKSSDAVKWLSELGVPLTVLSQLGGASRKRCHRAPDNPDGTPLPIGFTIMKTLENHIINDLSHQVTVMTGIKVTGLESTSHARPDGVLVKHVTGVRLMQGDGQSRVLNADAVILATGGFSNDHTANSLLQQYAPQLSSFPTTNGVWATGDGVKAARELGVKLVDMDKVQLHPTGLLDPKDPSNRTKYLGPEALRGSGGVLLNKNGERFVNELDLRSVVSQAIIEQNNVYPGSGGSKFAYCVLNEAAAKLFGKNFLGFYWHRLGLFEKVEDVAGLAKLIGCPEENVTATLKEYKELSSKKLHACPLTNKNVFPCTLGTEGPYYVAFVTPSIHYTMGGCLISPSAEMQTIDDTGVTPVRRPILGLFGAGEVTGGVHGGNRLGGNSLLECVVFGRIAGDRAATILQKKSAGLSMTEWSTVVLREVREGGVYGTGSRVLRFNMPGALQKTGLALGQFIAMRGDWDGQQLLGYYSPITLPDDIGVIGILARADKGRLAEWISALQPGDAVEMKACGGLIIHRRFAARHLFFRSHKIRKLALIGGGTGVAPMLQIVRAAVKKPFVDSIESIQFIYAAEDVSELTYRTLLESYEKEYGSGKFKCHFVLNNPPAQWTEGVGFVDTALLRSAVQAPSNDLLVAICGPPIMQRAVKSALKGLGYNMNLVRTVDEPEPLSAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4V5</accession>
    <name>A0AC62A4V5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NADH-dependent fumarate reductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3420220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="XUY36784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="472" mass="50904" checksum="D6B8C6DC0EAF21DF" modified="2026-01-28" version="1">MVSGTHAARLVLKKGHAKPAAPGRGRPRFPGRWRGMMATARGAQRLASDEAGVPHAKPRVLRHAGRFLLRGAPGECAARSRKNGNAWGTAVQKAAGVHDSGELFEKDTFASGKGGSCQPELVRTLSDHSAEAIEWLSSFGIPLTALTQLGGASRKRCHRAPDNPDGTPLPIGFTIVRALENYIRTNLSDIVRIETNARLISLMHSKEDDAVVVQGITYATQTASGEGKIRKLQARAVILATGGFSNDHTANSLLQQYAPQLSSFPTTNGVWATGDGVKAARELGVKLVDMDKVQLHPTGLLDPKDPSNRTKYLGPEALRGSGGVLLNKNGERFVNELDLRSVVSQAIIEQNNVYPGSGGSKFAYCVLNEAAAKLFGKNFLGFYWHRLGLFEKVEDVAGLAKLIGCPEENVTATLKEYKELSSKKLHACPLTNKNVFPCTLGTEGPYYVAFVTPSIHYTMGGCLISPRLKCRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A511</accession>
    <name>A0AC62A511_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3420530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="XUY36817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="249" mass="26867" checksum="E25EB4F746CCB611" modified="2026-01-28" version="1">MSVAELQPRSLVAVNDGAEDVVEAELAAYEGHHTHLVEGDFFPAEAPEVEADGTAAAVAEKGGPLVDNIAAASTPVAPKPAGALPRRRVCWADEGHPDTARGLVRHITKFHTPPRGPHHDAAHPANPTRPTRVTAANPTPPPFREKANVDTTTYKFCKALRPAPKYAEWRWQQREYGVTPFEPQPTEAGQPNGAARTLFGELFQRSVVARAAEGQARVRNGVHKSPGCGVQQPFVRTGAVFDAPLRIPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A579</accession>
    <name>A0AC62A579_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ama1 protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3020100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="XUY36960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="155" mass="17674" checksum="A523A7548261B3C1" modified="2026-01-28" version="1">MSGKDGNHQNSKTVGTTGHNAVTNRGWWHFSLCVCCKDCDSCCESWCCTPCQLSRQCNMLANNRKEIHWPYCLLMTFCDYTLFIFSVSCIFVSETRRMARERYGISGSTVEDCCYGYWCTPCSTQQVLLEMTLMNEFPGATCYEVTSHPAGRRMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5F2</accession>
    <name>A0AC62A5F2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha tubulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1320080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="XUY36979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="451" mass="49683" checksum="3D47FCCC1FBC5BF5" modified="2026-01-28" version="1">MREAICIHIGQAGCQVGNACWELFCLEHGIQPDGSMPSDKCIGVEDDAFNTFFSETGAGKHVPRSLFLDLEPTVVDEVRTGTYRQLFNPEQLVSGKEDAANNYARGHYTIGKEIVDLALDRIRKLADNCTGLQGFMVFHAVGGGTGSGLGALLLERLSVDYGKKSKLGYTVYPSPQVSTAVVEPYNCVLSTHSLLEHTDVATMLDNEAIYDLTRRSLDIERPSYTNVNRLIGQVVSSLTASLRFDGALNVDLTEFQTNLVPYPRIHFVLTSYAPVVSAEKAYHEQLSVADITNSVFEPAGMLTKCDPRHGKYMSCCLMYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKCGINYQPPTVVPGGDLAKVQRAVCMIANSTAIAEVFARIDHKFDLMYSKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGAESADDAGEEDVEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5N8</accession>
    <name>A0AC62A5N8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Fatty acid elongase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1420030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="XUY37000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="285" mass="32339" checksum="369667F02A0F1781" modified="2026-01-28" version="1">MQWVDNWGANHYDGYAFKQWLLDNHDIAIYVAVGYITFVFQAPKLVSKYLNLPANAKTSPLVPVINKTWAVWNILLSAFAFYGTTRVVPPLLYNLKTYGLHDTLCTFRPDEFYTSDVGVALGLFTISKVPEFGDTFFLVLKGTKLRFLSWFHHTAMFLYVWLSYETGSSTLICAAAMNYFVHTIMYFYFFLSEAGFKSLARPFAMYITLLQLAQMVGVMFVSGYVIVQKYILADQGITDGMTGSCSGTTMATARLQLGIYTAFLYLFGEMFMNNHVRPRAAKKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5Y3</accession>
    <name>A0AC62A5Y3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histone H3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1620150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="XUY37026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="66" mass="7238" checksum="D87F239EB5F19D1A" modified="2026-01-28" version="1">MPCARCRACRRRGGPALPEQRDPGDPGGVRCVADGCHEPGQHPREACVTVRPKDVQLAVRLRGERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A644</accession>
    <name>A0AC62A644_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Kinesin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2020740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="876" mass="94918" checksum="4F0DF99DC3FC87CE" modified="2026-01-28" version="1">MRNADSREDTPSPPRRTRQVVWNHRNVDAIPSDLTRTSAHVDPISSSGAVNATRTLRESKRYFGCIRVVVRCRPLQPDTEADHSAERVHINGDEVIVRDRMAPNEGRSYRFDRVLPAEADQVATFAEIAPLVEHVLDGLHATVFAYGQTGSGKTYTMDGLRSSGLNLQQRQAMVPHVDGTAVQQHGIMLRIIQLLFDRARERQRAVGVEDAESPDNAGTTDDGVAYTFRCSFYQIYNEKISDVHRGIGVSANANEAAAPLPFSSSTLAKLQMDARGKRGVDQGDLRVRWHKGDVFKVENLFICSCNSPDEMRGMLFSGIQQKVVSSHLINRQSSRSHCVFTIYVESRARPNGELLSQSELSLVDLAGSEKIGLLSHRPGAKLIKESIDINTSLLALGMVITALRGGAAEATSTLKRTNAGVVSHARGGAEQHTGGRHIPYRDSKLTMLLKHALGGNSLTTMIACISPSDRYVEETISTLTYAGRAKSIRNAPHVNEDATTLLMRKLRGEITQLKTEVGCYREMAMKSLVEREGRANVCERCSGVVYTNSLRPADPSSSIGRSTAADVTTGQEVDELADSLVAACGMLAKLMQANAELREFYGAARGVQDAVERREAELNAENLSLRERLAMLEDIVLQEDLEEVKEDSLLGDADAKGMLNSSKPPKQARPSRERPELSRAVGGPLSAVTQTTALPALEQCTGDRASRAGAVNDSATGGSSSQRSTVSSTDVGRPATVVNARCEPSKRSSTSPSTRSAARVSAPHNGAVASPVRTIALGPSPTVEQLSSVLHGLPSGIPALGDASEALLMRRADRASLRKRATEDKDGRQEHGRKRQGRSTVVAWRGDSRSTRRGTGCRTPLKRTLTPTSSRFAARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6J3</accession>
    <name>A0AC62A6J3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Leishmanolysin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">GP63-10</name>
        <name evidence="1" type="ORF">LPMP_1020170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="XUY37369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="584" mass="63388" checksum="7D0362BCD7D68964" modified="2026-01-28" version="1">MSRDRSSTHRRRSVAARLMRLAAAGLVMAVGAAAVWAQAAGHHCIHDRLQTRVLQSVAQQRRPPGSVSALGLPYVSTGPISSAHTVDWALADSTSPSVAHSADWGNMRVAVSTADLTDPDYYCSYAGQLVNNHQGAIDICEAKDILTDAKRHILVNYLIPQALQLHVDRLKVKQVQGRWKVTGMEGDVCGSFKVPEAHVTVGVSNADFVLYVASVPSGPGVMAWAVMCQVFPDDRPAVGVVNIPAANIRSPYDQFMVRTVAHEITHALGFDLTVFEDMEIVGDVNNLRGRNYDVPVLNSPTVMTKAREQYGCPTLSFLELEDTGGASTAGSHLKGRNAKDELMAPSVTAGYYSALTMAVLQDLGFYQVDFTKAEVMPWAHLASCDFITKKCMERNITQWPWMFCNTTESSYRCPTHRLRLGTCGIVTYDDSMPKYFQYFTNPNLGGRSSFLDYCPIIVGSSNGACNQDPSMASPSLKEFNLFSDSSRCLEGAFTPKHSTGPPGPYNGLCANVKCDRAHHMYSVQVYGSSGYVACTPGQRVELATLSAAFVEGSYITCPPYVEVCQANIKGIINFEGDAADTAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6T7</accession>
    <name>A0AC62A6T7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SLACS-associated protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0220210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009371">
        <property type="protein sequence ID" value="XUY37406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1016" mass="109705" checksum="160939D4720A09CA" modified="2026-01-28" version="1">MYPDTAEQEEEDTGSAPRSAEPRTETHTPPTQPPGTEGEGEENDTAESANTEPDQTVEDVSQTSDEARHRFHHGENTAAQQTGTIHCPVCPRTWTSRARRQQQTSHLNTTHAREVVRVDALKATGVDRCLSCGEFVIASGNARRAHGQKCGEFVTRAVRNQKRARTEQSTPRQDAVAEPTPETPPPPTRHRTRPTEADAEWVQEFPATIRTLRKQEWGHWAEAVGHTLLGYTAAAAADATSASSRLPSWCALVSPNRAHQRGEEDESHQEEPSETPREGGRDEPYTGHAGATRRANTEEHLPTRDAHTAEERRARRILHQLSLGAVGKAARTPVPGTAPTRARQRGTGSASHASPAGRPSGVPVPTADAFSPRPKAGEGQERGAETARPSRRTGARRMDPGTARSRGRKCGAPGGDDRTDARHPRRERVGVLRVPPPRVRRPPVPERTGIAEGPANHAGVGVAENRLAPRTGRGGKAVPRHLPGVAIRGVGRRRRGGHPDPGDVRERVGRHARRAGRDQRVQPRLPRMGAEGGVPPPRPPPHGWSGGPFPRRTGRPWRLRGRPPGRTTLVDARRPPGHGAQSPSLRHRRGGTLRPIMAAHPLAKVTAYLDDLTVVGPRAAVQAFLDEAGPALAATGFDINPAKSHHLSKSAAPEPVSVAGVVVPLARGVVRILGAGFRGSGAPVDEWVWEKTRPYEAYFTALGGDELPRHARMNLLRASALPRLTFLLRTHSTDELRDSAAWFDDRVLHTLSVLAGGAPIEDAAALLARLPPCHGRMRAAVAAGYLALRGAKRRPERRAEGTHAPTGPTQPRGPQNTPPGACPRDREGQHGARCHARARRPSASPGRLPLRGPRPPAAPPTGSPSRGAVRMRGGRGQRARERMPVGPRGPADPAPQPRPYGHRGVGQTTRVRSGRGAPGEQHERRTARPEHRRGGRDLRHGRGDHVPRPSPQRPAEPPSAGTRREEAEVGRLGGRNRHHVCTGVARVDRGPPQGELPVAAGRRGLRQLPVLHANRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6W7</accession>
    <name>A0AC62A6W7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0420030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="XUY37420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="522" mass="52693" checksum="0F3DC9132BDCD79B" modified="2026-01-28" version="1">MAPLAPRCCAPALLCAVLVLAAVLVRAESVTVTDDLTMSGASFNDYTMTLGLASSTADVVTVQLMNSQVSGKGLTVQSSGDGLASSARLSMSMLLTTVTQAAITFSGAMPANSDIRIVSTIGSLTSAQSLFDFSGLALDSNVTVTVENTAVTWPKDSINTGSIVLISAGSNAIGIRNLAALFVLDAVATNGASVVRVDAQSSFPVSKAAVLAIDYGRCEECTGALVSINAPLVVDGSSMFRVTNCKAVGASKGLLASAGSTTVSGKSVYLVSDSAVESVSLFSFLTGIEDSSEPYPFTVSGGSTVSFLNLEAPSTGITNQDTLSASADSKVIGGGCVIKGVALNTAEVYKSNGLAVTTVVDRQGASGGTCANAKCIPGNTGAGAAVSGTDPCTCQCSSMDYNPPSCSTIVDPTQNYNPTDVCVVPNCITCDRLSPSTRCTQCATGYILTSDQRCILPTTRPPVCNVPYCTQCVTGSGSRCSTCHYGYTSINGACIANANAAAGAHTVALAAVVCVAAALYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RH00</accession>
    <name>A0A088RH00_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA primase large subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_030080</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic-type primase large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009372">
        <property type="protein sequence ID" value="AIN95242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700950.1">
        <property type="nucleotide sequence ID" value="XM_010702648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RH00"/>
    <dbReference type="GeneID" id="22571874"/>
    <dbReference type="KEGG" id="lpan:LPMP_030080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_030005700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_030080"/>
    <dbReference type="eggNOG" id="KOG2267">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="421393at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07322">
        <property type="entry name" value="PriL_PriS_Eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058560">
        <property type="entry name" value="DNA_primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016558">
        <property type="entry name" value="DNA_primase_lsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007238">
        <property type="entry name" value="DNA_primase_lsu_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537:SF3">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04104">
        <property type="entry name" value="DNA_primase_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26466">
        <property type="entry name" value="DNA_primase_lrg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009449">
        <property type="entry name" value="DNA_primase_large_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA primase large subunit C-terminal" evidence="12">
        <location>
            <begin position="341"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="534"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="502"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR009449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR009449-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIN95242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="567" mass="62840" checksum="F79EE0A510183958" modified="2014-11-26" version="1">MQAITASTLPQQYSAGAGEKKALVAMTSADWMTMYEQKPHGNSTLFELEAMVAKRMELLAWIDQRMNSPQAKSFESVLDTIIARLPEERRSSTATDASRGKIVSLGYDETASGSGSGRRSSSRGSTGGAAGSSQAASIVFAPEEDVTSHLLCRFAFCMSERWRDWLVRTERVLLMARIKMEVAKSPLTFLVDLMKHNGLPCAPLSDVQLADPLLQEYLEYRRVKADSARESEGRAENYYAVPLSLATRLIKKRHVLCRAGQAILFRDQVQEVFLAVFCARLNRGLHSAYLARVKQQALEEETAKSTVMAMLDAFLQQFVSDPVDSLQEGVAGTVRAGDVQQLAQTHFPPCMRAVDSHLRREGHLKHHGRFTYGLFLKAIGLSLEDSLELFATLMKVKGGGSVEAFSKTAYGYNVRHNYGMEGKKTSYSSASCATILGLPPVVDQHDCHGCPFRFRDEGALRTMLGKETPNPKGRTYPSVRPAPGDIEDIVSDCKSQHYTRACYKYFMAIHPDARRDTLFRSPYEYFSVSLEFETPNDGTESARSSAGPGKRTSMGLYEDAVRPRTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RH21</accession>
    <name>A0A088RH21_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PTP1-interacting protein, 39 kDa, putative</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_030370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="EMBL" id="CP009372">
        <property type="protein sequence ID" value="AIN95272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700980.1">
        <property type="nucleotide sequence ID" value="XM_010702678.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22571903"/>
    <dbReference type="KEGG" id="lpan:LPMP_030370"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_030008700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_030370"/>
    <dbReference type="eggNOG" id="ENOG502SHIP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266912at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037">
        <property type="entry name" value="FORMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037:SF24">
        <property type="entry name" value="POLYCOMB PROTEIN PCL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="400"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="544"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="668"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="792"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1319"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1554"/>
            <end position="1573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1695"/>
            <end position="1759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="400"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="678"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="801"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1340"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1701"/>
            <end position="1722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1730"/>
            <end position="1759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1759" mass="186817" checksum="86451CC66C8725C2" modified="2014-11-26" version="1">MPKLDAISKGPWRHISQQQRQARQVQRAEPTIGEVLAQSSPMTTQAVTGVRVVEDAHDGENNVERTQEHSHIVNTQSETPQQPHSCLEESHVHSAARLIHRRARSVLPQPRETLTNWKVAVDGGVAGNDDNRARQGPMQSPSEPTAHALEELFNEEQSAEEQQVQQGVTVQRVAQLLSPSSPHQRTNRAEEEDLFSNISTRAYSSTVAFDQAGIATVNTSRRTALRQCASGVPPPAPHVTSTAVRAVPHASPGPLWVWLPRRVEALCALTSLGSPQLMRSVADGDRSQDRIRTTPPHRRSSTLFFARGGRGTYSAPRDYIGDGDYGLQVALWRRTPCSTPPRTGLTADGANGAPTSLLSSPRWCVTAYEPLSLSLPATALCGNDASQGWVPQQAPVSFTNFSHPSNSVDSNVQRRHSTREDESVAVNAQDDEEAAAVSKCHDHPLLTVMASAHSPAPPVSVATRVYWGTAPPLRGTAPSMLHHGGTTAIDAYDAGSDGAAFAGSRSAGQIIRNSAQAGARALDQRARYSSVSPADESSSIMATALPSQHQRGGPRGYGSSGARPLRDSATAGFDRDELFCEPPSSPLSATCRQLPAVSGSVACVPIPSMELRITLPWLLHISTLPPVAAEALVCCLEAHIRAHLPRATAAQGERNGMCGPRPSGACAPGPALARAQPTPSPREAPPLPSPPPFWVAAFSYTEGLQMYATNQASSLIHAAEDTTGRDAARDTCADPRHDHRGLASAAPLNRIAWPAWVPEAQTSVRLLAALTSGAFTLIETIARALDQATAAAAAPVDTDTAVERGTKARSGGKERHNAGADPHTVRGGAPRSTPTHPHGAATALHEFHVFFEAVFGDAANKRLCRHVRDRLPMHVRDLSELLSRPWCGVARDTVDGNAATTAVTVATAGVWRARCPSILDLVHHLARAWMEECFAGLADRLHEFLITHNPGVVLDLICAHANDSDGAVPHEDLCECARLLKGVCDKVRPENGSVQQRGCASANHEPHQREHPGCSAPLHAVPQAAQVLPPHAWIYRGIAEFTQGPLQRWERWWWSPSSTPATHTLTAHITVSAAAMQWSTHVNYATVHSLQWVLRHPLVACTTAESVRQCSLTSTAVTDMLALLELLTLLPPLLDTTALLMGEAEAVLGGACASVMGNAGDGRDGSGGGGMAITTSSVHSHNAVIASTPAAPSHAATQGFHAYYRVFLGLVCYGAMQLNDAEAMALLSRPQPPPAGVVASTTAPHHHGAASPLSVSCSAQATVDGLWTKYILPLVVGYVSGSGAGDASADRMDALTAADQSIVYTLMLLRLLRLEGHSVRHGSRGGAARAVLPTKGRQGAPNSAASSPSSSRHPRKRPRPAAVGVSGPLPWCNARSAHPGSDDTRPRWWSPSPTTADVHPVTARSPPPGSVSSSTVTADTATTATTTATTHCCVNSDLARINELERVGTAVAEARYSSAPEFGDAPQFRPRHAKSVAHDAASGLVDVLVAVSQEELLAPPQRRIPPLALLAHESAAGGATAATQQCPPSPAPPPEWQGACRQLIRRWLLPPPRAPAQSAVHERSSDSHQTLMNGDCHSRRCREWTPEEGTMLHEEEANHCASVKASYFSGGLPRRPQWLNVGEVNTGNTLHRRDIRRVCGLLAGLALRVADVRQEERIARAETLHSDDVRCCYDYLYGVLPPGLRARDAGLITFASTSSSDDGEDVNTEGSGEDAGTDDDLYDANMLHCSASTISSSSSSSRNTIGTSSPPSSSPAASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RH85</accession>
    <name>A0A088RH85_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_020430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009371">
        <property type="protein sequence ID" value="AIN95223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698188.1">
        <property type="nucleotide sequence ID" value="XM_010699886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RH85"/>
    <dbReference type="GeneID" id="22571853"/>
    <dbReference type="KEGG" id="lpan:LPMP_020430"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_020009400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_020430"/>
    <dbReference type="eggNOG" id="ENOG502S70X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275184at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39665:SF1">
        <property type="entry name" value="PARAFLAGELLAR ROD COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39665">
        <property type="entry name" value="PARAFLAGELLAR ROD COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN95223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="162" mass="17529" checksum="8A8473F724BF4698" modified="2014-11-26" version="1">MPNVIVTCTFNPPSVTIQGASIRQDTIDALQRALPKQTTTSLPTQRPSEPAKFLLTSRSGTVQAGTVNRIEAGGAVADGVAEGREEFSSPNHNSTGVASGEDAEAYKSWHVDLGQHYCDQMGRTMIFLVIIEALEEEGFGLRGTHSLVVKEKDITRLIFVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJ49</accession>
    <name>A0A088RJ49_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_091020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN96017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704339.1">
        <property type="nucleotide sequence ID" value="XM_010706037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJ49"/>
    <dbReference type="GeneID" id="22572672"/>
    <dbReference type="KEGG" id="lpan:LPMP_091020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090015000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_091020"/>
    <dbReference type="eggNOG" id="ENOG502QVI2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="248381at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="614" mass="67284" checksum="D826EF4440DB029E" modified="2014-11-26" version="1">MPSNKVLAATGAVLASAAFIGTIVVMRSHKKGTEDDDDAFSAPVSSVSQSKKQIFSAPKAVSRPTEASTSEVPLSQKPKTALPAQPVTAKKDASAPAVVNMLTVSDPAALLLDEALDELKPAIPDAIGEGTKVVSKPATANVATVDSSDRKVFQHLGISMKVLEGWEVREELSPIPNVAMVTVWNPEFEHFPNAEMPGAVPVIILSVEDIRGENLNLTEFKDRSKDLSMQQMLMMTGGVVQPAVRKDSTVQEGSFRHILEYSQSMPPFFDLSVINLLEVRNGVAYVFQIMCNPKIMNQYRQIFMQLARDIVVTPMDSSSLGFFRVHTGKVSMDIDTTWSWEYPAPGDEATLYLAKFQLVSTVKKEEITLYEVNKVPTTAHKQRKEKAIDGVTICSAFDGTQEKKTFTYNNYCLVVNPQQKAISYLSEAALVRAVKSVAPSTKAPKPKCGAAFITTEYGYTFDAIGSSRVVSTKLGNGTVVYAPQGIPSDPSKAASPEETGPTVTIRIGKPETDTDCMGSIEEWATRIQEEAANGTITKIQVVRLKEQDCLTFLSKEMQEVSPKEKVEVVGKVFIFVRNGTTTLVRWESATGTWRKYERDMDAFLESFQFLEESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJV2</accession>
    <name>A0A088RJV2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_100160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696738.1">
        <property type="nucleotide sequence ID" value="XM_010698436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJV2"/>
    <dbReference type="GeneID" id="22572752"/>
    <dbReference type="KEGG" id="lpan:LPMP_100160"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100006800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_100160"/>
    <dbReference type="eggNOG" id="ENOG502SM45">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267448at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051201">
        <property type="entry name" value="Chloro_Bact_Ser_Proteases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43343">
        <property type="entry name" value="PEPTIDASE S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43343:SF3">
        <property type="entry name" value="PROTEASE DO-LIKE 8, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="586"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="107"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="294"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="410"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="113"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="309"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="341"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN96085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="667" mass="70141" checksum="762DB2C466E154BB" modified="2014-11-26" version="1">MSAHLTEKDLFSALREYVSRLEVQYMIEEEVKKFQEKVLPRLLSEAFAAASHGATADQMASSPGPSTTPAPSHVTATPNIEWVQTFLKAHADDALSRRLPSMISHEVQRQLRSASGGAQTESSAQASSSSSRSPPRGEAVVATAAAQPRVGLPPLPPSPPRPSLTLPPEITIVSAETSSAKHQGDGNRNFTSLASTAHDEGRRQREQVLSAISDIEHQLKDVQRDINEVVHQQRLSRCRLEYLCEVLQGTDLFPAAETRPSSLCVALKQALDDRQADAVRARLAVMLQGLLPLSTEPHPGRGTVVDYQPTFTLGGSPSPTPQDVQQSSPSAASVKSYAVPSFSSDAQRQSLTRSPSRLRCGLPSPPHSASGPVGAPPAHTPHSSGACPASTAPTWACTSVYTRHGDAAATTPGTFRPAGAAPAKAVRSITTRGTAASSLTPKAAPPPPPPVAQQPSALRTTHGTAPSPLPVLRQQSHDPLGAGGAVSRPTPLPQECAVPSMRDKTRRETHRRTSVRAVDSTAAEADEAAPRATYTHPSNARFLSNMGRDASSSSIISAASSREGAAAGWASRAVVLGIDALNVPSGVLPGALGRQGAVRVQSIAPLQLAERAGVCRGDILLSVNHHSVSNCEELRAVLAAVPATQLTIAAELYRDTIDQIVSITLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJW1</accession>
    <name>A0A088RJW1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_050230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NARF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="AIN95464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703786.1">
        <property type="nucleotide sequence ID" value="XM_010705484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJW1"/>
    <dbReference type="GeneID" id="22572101"/>
    <dbReference type="KEGG" id="lpan:LPMP_050230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000024500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_050230"/>
    <dbReference type="eggNOG" id="KOG2439">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253113at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000042">
        <property type="entry name" value="Cytosolic Fe-S cluster assembly factor NAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.950.10">
        <property type="entry name" value="Fe-only Hydrogenase (Larger Subunit), Chain L, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050340">
        <property type="entry name" value="Cytosolic_Fe-S_CAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11615">
        <property type="entry name" value="NITRATE, FORMATE, IRON DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="Fe-only hydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iron hydrogenase large subunit C-terminal" evidence="6">
        <location>
            <begin position="152"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN95464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="602" mass="63750" checksum="F4BF074E6AF26497" modified="2014-11-26" version="1">MKRGGNALSHDPGIPAAAQHPDVVKITLQDCLACSGCVTTAETVLVNAQSRHEIVSALLTSPSSTSSSATGMGSAYRPRLVSISTQSCASLAAHLQMPVATVYELVAGFVRTALTTAALQEAQRNAAIAAAGPLPAVTGNAKETKLSGEMSGAPQTAAPDAATTAFPNSEPAVFVIDLEWAEQLSAELTAQEYDRRRRGGGNAEVGPLPLIVSACPGWVCYCEKQGSALLPHLCPVMSAQGIAGSYAKRTVAADLYHVSIQPCFDRKLEAARDSMALATAPLTEKVDTQVFYTDCVLSTAELLEWMKEVDPTLPWRGQLDTDITTTAAAALGGDNCTGYPAQQPTQLNEEELSASAPPPSAPAVFAPAHDATRFAGSGGYHQSVIAHRLQAERAATLPPSLSSSPNTSTTITYEVRRNRNHQLATCAALPGEVFCIGYGFQQIQNVVRGLKKRMPAMRSYTFIELMACPDGCLNGGGQVRPTQQPHTETLDIVLDAYARHIEVSRGRSSLPAATAATPSGSALACVSASPYCDGGDEQAENREDAMKAQRPRIEAAQQPFANATIAATAPSLGDALWRCTFRDREKEFAEMLNDGNVHRLKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RK75</accession>
    <name>A0A088RK75_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_060080</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703891.1">
        <property type="nucleotide sequence ID" value="XM_010705589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RK75"/>
    <dbReference type="GeneID" id="22572214"/>
    <dbReference type="KEGG" id="lpan:LPMP_060080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060006100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_060080"/>
    <dbReference type="eggNOG" id="KOG0061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="184675at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001495">
        <property type="entry name" value="ATP-binding cassette protein subfamily G, member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF102">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="427"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="505"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="533"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="628"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="65"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN95569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="657" mass="73268" checksum="BE07EF8B7D6FE5D0" modified="2014-11-26" version="1">MPLLNSELMDEGNSINVADPDFTARSERQIPSSLNISLEMPPSTANLDSDTLNTGSVPDSYSLPLSWRKLSYSAGKKRILCGLTGTALPGRCLAILGSSGAGKTTFLNAISDRLASGGALRLSGRRQLGDCELERHFRKAMGFVTQDDIISPLSTPYDALWFSLRTRRGTGRAETEERVQEALDVLRLQHCRNTKVGIPGLEAGLSGGERKRCSIGIELICDPKVLLLDEPTSGLDSVTSAKVVHLLRQLSRMGRTVIYTIHQPTAEVLSYFDDVMLMTQGRIAYHGTMAASLDYFESIGFVCPSKYTPTDYYMTLLQDSATSKILIKRWSKYLKNGPRTPHSAAVRLAKSRRESSAARFLDAYIVKFGSSPVVQFYELTRRTLIEISRDSVYLFSYMAQAVFFAVVVGLIFLNLRANVEGIQDRQGLLFMIVMNRAMSSTFIMINTFNNVRAVYTREQQAGAYSPLMFFLGRSVAEFPVQILAVLVESCILYWMVGLHRAPGSFFYYCGVVALLSQVAAGLGFAISTACPSLMIGSAITPPILIPLALGGGLFASTDRLRPYWYWIEKPSFMRHTYILLMRNELYNVHNITCDNRRWGDEYCINHPRDGRTVLRLLQFDGDPQSESVYMWVSLLVLFFLLRLITVVTLTVAARARM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RK92</accession>
    <name>A0A088RK92_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_130120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697095.1">
        <property type="nucleotide sequence ID" value="XM_010698793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RK92"/>
    <dbReference type="GeneID" id="22573122"/>
    <dbReference type="KEGG" id="lpan:LPMP_130120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130006400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_130120"/>
    <dbReference type="eggNOG" id="ENOG502S6U0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271770at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="119" mass="13947" checksum="00DD0A85F354FFBE" modified="2014-11-26" version="1">MKELEELRLRNQLLRAENAELQSKLEDERTQRRQSQLDENHYSLEAKACREAIEKIDSKAQVLALHDELHHLRKKCDIYAAALEESRSYFFEMKRLYMEVSPHLRSFSGDAPAHHAAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKD8</accession>
    <name>A0A088RKD8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Surface antigen protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_120750</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009381">
        <property type="protein sequence ID" value="AIN96403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697056.1">
        <property type="nucleotide sequence ID" value="XM_010698754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKD8"/>
    <dbReference type="GeneID" id="22573081"/>
    <dbReference type="KEGG" id="lpan:LPMP_120750"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000005900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090011100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_120012300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340010200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_120750"/>
    <dbReference type="eggNOG" id="ENOG502QPYS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1877432at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000095">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase GSO1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052595">
        <property type="entry name" value="LRRC69/RLP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48057">
        <property type="entry name" value="LEUCINE-RICH REPEAT SERINE/THREONINE-PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839012" evidence="6">
        <location>
            <begin position="21"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="770"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine-rich repeat-containing N-terminal plant-type" evidence="7">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="649"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN96403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="794" mass="84610" checksum="2645021A6969A365" modified="2014-11-26" version="1">MRCTRWLVLAAILAAAAVRATVTGDFTAEQQSNTLAVLQAFAGAIPELQSTWSGSDFCSWGGVTCAVSSVRVAGINAMYAGTLPEMPAGVDYTNVMITRLDFSTMARGLSGTLPDSWGKLRLLQSIVFVGCNVSGTLPASWSALSSLTELTIQGSGSITGSLPPEWSSMSSIEWLKVAEEQLSGTLPAEWGTMTSLKMLELSVASSITGTLPPEWSGMTALLYLYIDNSLLSGTLPPEWSSMPRLKDVSFRGTQVSGYLPVEWQSIKTLRRVYLTNTSISGTLPVSWTILKSLEQVYLQGTRVSGTLPPEWSSMPSLVHLLLTSSSVSGTLPPEWSSMSKMRFLSVQGTQVSGTLPPEWGSMMMLENLQMSNTQMSGTLPPEWSSMSALKNVVIIGSSIIGTLPPEWSSMSALRQVVLTSTQVSGTLPPEWSSLQLLQELHLSNTQMSGTLPFEWSSMSALEQLVLTSTQVSGTLPPEWSFMSALEQLVLTSTQVSGTLPPEWSSMSALEQLVLTSTQVSGTLPPEWSSMSALEQLVLTSTQVSGTLPPEWSSLQLLQELHLSNTQMSGTLPPEWSSMTSAEVIALINCDLFGALPSSWSVIPRLRNLSLNGNSFCGCVPASWASKPGLVVSIEDEHMGNDCTTENICPTTTTTTSTEPPAVSTTTTTSTEPPAVSTTTTTTSTESPAVSTTTTTTSTEPPAVSTTTTTTSTESPAVSTTTTTLSPDTRCEVDGCVKCEDDSSVRCARCHDDYYLMDDKTCLVYCADDVAAAPSGVLTAAVVCVVTLFSMGLVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RL25</accession>
    <name>A0A088RL25_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_080810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="AIN95889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704211.1">
        <property type="nucleotide sequence ID" value="XM_010705909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RL25"/>
    <dbReference type="GeneID" id="22572543"/>
    <dbReference type="KEGG" id="lpan:LPMP_080810"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000011100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_080810"/>
    <dbReference type="eggNOG" id="ENOG502SN1G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272669at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN95889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="146" mass="17215" checksum="4B3547EFF9B73604" modified="2014-11-26" version="1">MFRLTFPLCLSSKQLSHGPLATHTHKQSFRQSKEALQTSRRRSQTLRTNFSFQQKLNQEFGARQHTFAQGRRSMQGAAEDLMYDRAYHAERRGGRAGRVYRTAKDRAAEMATARELLHMEENTRRLMKKGRTQRTELFRAQRQWGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RL65</accession>
    <name>A0A088RL65_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_150390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697415.1">
        <property type="nucleotide sequence ID" value="XM_010699113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RL65"/>
    <dbReference type="GeneID" id="22573455"/>
    <dbReference type="KEGG" id="lpan:LPMP_150390"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150009000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_150390"/>
    <dbReference type="eggNOG" id="ENOG502SAFF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272876at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="632"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="679" mass="72972" checksum="D129923E061BD6D5" modified="2014-11-26" version="1">MRISVAPEAVARRHERPSTLCQGSMTQNASHRVLSECGGLSLLRPAVHATFRLPRQHSRQALSLLAAFAVLACLCSPRVSAISDAFEKVPNAFSSTGTAVRAVYEAMQLTSDNFTLGSWEPLRSSAYVLCDANGDSFSDAAARSASPAVDFIAQAWCTSYGMGILVNQSVHWSTMAPPGLQLGNSSMLSSRALLWDCLTYSCDMENLIVAHSAGQAPPPAVGGLGVSTPCCGSTNSTFVLYMTRGLLVQSAALPVAALNREAEALYSSVIDEENTRNSLNECRDTGSSRSGAGNRALRSSKSCLTAAAASRASLAEAATTPSRSKEMDFCLVRQLPPSLFAGTARSDHGDGGVVFSVNASICGADITDRINEQDATLIMRGYTVVLTTAEGVEELSFPKELIVSMASWIASPQNNSSSCYDGEQSLLRKKGCCTWGLNASQTTAYRTGEYLECPFDPSALAHLPPLVLSVRDESIVSTDETSNACRIALHLSSCMTPDGKALRFYSTGSLVSMLERHKHTMGDYREPPIVVGMQQLRGATVAVTRRARISKWSSGASDAGYNLPLLYLAVPRGTAVAADVNTLGALCVTSAACGTHQTFYPSLNRCAYVPCTRVFLYSFDADTFTCTPRRTFVGIFATLCFTLLATEGLVLYLRRKTEWAKEVHMRLVRQVQRRDTEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLI5</accession>
    <name>A0A088RLI5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fucose kinase, putative</fullName>
            <ecNumber evidence="7">2.7.1.52</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_160480</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.52" evidence="7"/>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN96922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697575.1">
        <property type="nucleotide sequence ID" value="XM_010699273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLI5"/>
    <dbReference type="GeneID" id="22573625"/>
    <dbReference type="KEGG" id="lpan:LPMP_160480"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160008900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_160480"/>
    <dbReference type="eggNOG" id="KOG4644">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271303at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050201">
        <property type="term" value="F:fucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042352">
        <property type="term" value="P:GDP-L-fucose salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012887">
        <property type="entry name" value="GDP_fucose_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052203">
        <property type="entry name" value="GHMP_Kinase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001174">
        <property type="entry name" value="HddA/FKP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32463">
        <property type="entry name" value="L-FUCOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32463:SF0">
        <property type="entry name" value="L-FUCOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07959">
        <property type="entry name" value="Fucose_pyrophosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00960">
        <property type="entry name" value="LMBPPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GDP-fucose pyrophosphorylase" evidence="6">
        <location>
            <begin position="99"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="5">
        <location>
            <begin position="968"/>
            <end position="1045"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN96922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1227" mass="131626" checksum="A8FF0C46FDBDC9E6" modified="2014-11-26" version="1">MSLNFLFSVPRCLAEYSGAKKLLGDAASLTVHEHSAKGDVAAPGLFCGCDPEGKPLGSGGGTVHLLHECYLDEQRHAPASAKKSFLSWLRLGDKDGRVIVHAGGLSRRLPAYAAVGKALVPLPPCRWRRGSQLSRTLLSTQMPMYREIITTAPANLRTLIACGDVCVYLRGSLPSFSHFADKDVVCFGIRTDTHLLENHGVLFTTCEKPLELDYMLQKPSLAEIRQRTAEGRHSFLLDVGMWMLSDRAVAILARKCLGRALDTDDVNGGEHDGHRCAVVCNSYELYSEFGTALGRNASQADPEVSGLKAGVVELRDAVFLHYGTCRQLISSTAKLQSCESPTPSWSWGTPFDGVLAPECNDGKEARLPTAAADAPAGDAGEELDFAAGDAVPLLATPSSVIVQNSVLLAPLDGSAAAAAAAGASAFAPVSPVHHLWAESSWVGARWVLRGQHILTGIPRNDWALALPLGVCVSVVSVLPAALGGRGCGDGAALHAARPYHIDDAFRGDVRNGSTVYMGLLLHDWLSSRGFSVAELYPTARAADRDTAQPLDISEAALFPVCVTQQQLGDFLYVATLSLEATTGGGAAVDPVRLSAGQAVWRTQPRVSAMDLLRLADVPAILRNSEYYERRMLTLMLALVGANPVFQGGCSSVVSVPNTPMATPALSSVRPSVLSDSMIALLQQQFSLLDLSRVAKRVVELGVTLPRRSGTTEEWDGVDATAKTVSLPHQPDSIESFGSDADATASSWARIFTDEKSPNGDRRGAPLCLASGRIVTAHYHMFVSRVIELALEAMDAAQPPMTAAEKARRLELLHAPSAKEARSLVTRHSATAFAELCAAIVDSFPGERHNPEIGVHLDQIIWGRCPIRIDLAGAWTDTPPYTILSGGSVINVAVELNGQPPVQVYVRARKDPTIVILSIDSGEQLRISSFDEIRTYTAVQNSFSIPKAALALCGFLPEFCTTAYATLTEQLAARFGNHGLEISLFVAIPVGSGLGTSSIVAGTVLQSLAEFCKLPWDVHDVCRRVLLIEQMLTAGGGWQDQYGGLFEGVKLVQCVPGLPCLPTVRWMPDNVYTDPRFASCHLLYYTGITRTAKGILTEIVREVFLNSGATLQLLHEIGGATTAAMYNAITTGNYERYARLIHRTWDQKKRLDSGVCNPAVQSIVDIVEPYVWGLTLPGAGGGGYMYMCAKDEACARRIRELLTANPPNGNARFVEMSVSSSGLKVSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLZ2</accession>
    <name>A0A088RLZ2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nucleolar RNA binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_151330</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697508.1">
        <property type="nucleotide sequence ID" value="XM_010699206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLZ2"/>
    <dbReference type="GeneID" id="22573553"/>
    <dbReference type="KEGG" id="lpan:LPMP_151330"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150018800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_151330"/>
    <dbReference type="eggNOG" id="KOG2572">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6780543at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000005">
        <property type="entry name" value="Nucleolar protein 5, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000001">
        <property type="entry name" value="Probable Nucleolar protein 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Nop" evidence="6">
        <location>
            <begin position="264"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="400"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN96855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="444" mass="48999" checksum="41C5840ABF8E9007" modified="2014-11-26" version="1">MVYALLELPAGVALFKVDGERRKLKALLHFKSTADALETTAQLVNGELSKPVRRFLKKNYLEKEVSEELAVADAKLAKAIKETLAIPCVSGEDTLPTFRALKQGIDSLLEDVSAEQLNQTALGLAHNLNRYKLKFSPDKVDMMVVQAVSLLEDLDKEINKYAMRTREWYGWHFPELGKIVNDNVAYCKIVLAMKTRFNARDTDFSDFLEEEMEQKVKEAAMVSMGTEIAEEDIENISRLCSEVVAASKYREQLSTYLSSRMQTIAPNLTTMVGEQIGARLIQKAGSLLTLAKYPSSTVQILGAEKALFRALKQRQATPKYGILYNASVVAKAAPAQKGTMSRVLAAKASLSARIDSFGEGDNTPALEYRSKVENRLKAFEEGITYGRSGNARGVGAGMEQRRSYGDNQGNGFKRPRMNTSGFNNERGGRGGGGFKSSRPDNSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RME7</accession>
    <name>A0A088RME7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_120560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009381">
        <property type="protein sequence ID" value="AIN96384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697037.1">
        <property type="nucleotide sequence ID" value="XM_010698735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RME7"/>
    <dbReference type="GeneID" id="22573062"/>
    <dbReference type="KEGG" id="lpan:LPMP_120560"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_120010200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_120560"/>
    <dbReference type="eggNOG" id="ENOG502SMGJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266087at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="498" mass="53044" checksum="3A58C621E4E69835" modified="2014-11-26" version="1">MHSEQSICEFVHMQRELRRCYATMESYEVVVAQLRDDCALARAQLCRSRQEYAQPKKEVEAQVQAEATEQTNGLPLALQRLEANDASHENISAGPVHDAKDAAEEYLRGTWKTTVDELGRALREEQSAHAESLARLKEALTSKARWKSRAVELFKWREQVCREVYTSSAPLSSSFGAGTGAIRTSGAPPGVSPIRNCASDSQAKPSTGHSASNASSPFQLPHHSPSPHKLLQCVSFPSEARKLRSSMASEVSTTSAAPPDEGGPGDHVAHESEKDSNSTPGVDMSCQSDSTTGSILSASASLAGRITKALGSGVVVVWPPLTEEQARGTGKSAELSRTQSSTTADAMEARPSELCDDAGEQGLQPSLPINPISSSALPSSAGCCTMSTVESNVQEGCRASATGAEKAMVAAAPLRAVPDLFAFPSPPACGGVGCAIHRSLPRSDPLPTSCDVSATMAPVSAERKCKELLRALLDKEHQLSLIAEERTKYKRLYEATRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMP0</accession>
    <name>A0A088RMP0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vacuolar import/degradation protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_170670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697758.1">
        <property type="nucleotide sequence ID" value="XM_010699456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMP0"/>
    <dbReference type="GeneID" id="22573810"/>
    <dbReference type="KEGG" id="lpan:LPMP_170670"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170012700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_170670"/>
    <dbReference type="eggNOG" id="KOG2395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251113at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040458">
        <property type="entry name" value="Vid27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013863">
        <property type="entry name" value="VID27_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913:SF0">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08553">
        <property type="entry name" value="VID27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vacuolar import/degradation Vid27 C-terminal" evidence="1">
        <location>
            <begin position="245"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="556" mass="60293" checksum="C7CAE1E2F1ACAF55" modified="2014-11-26" version="1">MSASTTELFTNEGTLYQYAGEEGDHPYYKPLGDVDAFTISLVKHKKAPGTAGSDKSSVEYIIAVAEDGENVFEQPIGVDLQLSYSAPAASVHWPAIIDEQLETVAFRFAAPASRTGQVTAQMRMQEFVELYNRCTYSLLTGYDEVDPQDEWYQYLGGATTREVRNEDATEAVFEFDAAQLTKASTGSGNICAAESLQFNRILVVKKGNEEASLEMQALPQTERGFDRAAMEKLVVRGVDDTSTGTLLENGDATMLLFGGRKAAVQQLDLTHGTVVQEYKPADLPLQSVAYANHTAASSGSVYTCLGRNVAFNIDVRMDPRNCVIMEDGKQPTDYALLSLRKDFTCHATSQNGYLVIGDGCGNIRLYTGPPGARKPDGGYFPKAAKTLLDTKMPIVDIDVTADGQYIVATSTSFLLFIETKYVDSNGKESTGFQTRMGVQKPQPIILQPSPEQTLRMGGASMVRFQSAKFDRFPGTKELCVTASCGDYLLTWSLRAIESSQQSGRAVVNSAVAVGQTVLSTSANRASHVGFLTGNGVGVVPVHEAKMMSRAWTWGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNN0</accession>
    <name>A0A088RNN0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_201580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698359.1">
        <property type="nucleotide sequence ID" value="XM_010700057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNN0"/>
    <dbReference type="GeneID" id="22574367"/>
    <dbReference type="KEGG" id="lpan:LPMP_201580"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200021000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201580"/>
    <dbReference type="eggNOG" id="KOG3783">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="43460at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019412">
        <property type="entry name" value="IML2/TPR_39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10300">
        <property type="entry name" value="Iml2-TPR_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="647"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="662"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="805" mass="89879" checksum="1AA756590AB1C87E" modified="2014-11-26" version="1">MSQSLKKSSPGSCSPAECYASPMNMEEPDMAKLEQAEEESIAKMSSLSNADVQRLRSLTLENIREMDSYLQDAVDAFFANRITDCEATLRKRMNEDPLAVCGAGLIAFVRCCLSMEQTQADIALKLLTKSSALATQVLPSEMSMISSGFSKVFQRKKDPKSNWLSPAEFRAKMTEAESQALRCFALVLQQSVSSLLKAGLALNRASSSYKSLYAELEQRYKDKYRNNEAAMAPHDKHAASKEGDDKVKSPVGSLGGLTEKDVSLEEPAALETLGLDRNSVHSVEFGIGAISLALSILPANVRALLRFIGADSNRQEGLKFVRRCFKSDTLLSPFASALLLALYGMLPASSAFLVDSYLPVVQEVRMEAMQKENVRESILHLWLDGRIERLTRCVEVSIVKLNHCLDVASHPQLLTAMPQLRDFVLYDQWFNYAIMNQWKRASRCLELLSKTSKWANAVYQYVQACCLEMLEIEWAEGIQNPGGEEDFLLEDLHRIVGTSKMKELKLTFCNVSTREAIAETITRLYWEAAQRKPVTLGGKPNHNDQFVLKRMEEILGHHGITASTILGKKKPGEPLEPVPKGFVLRNIIPLPVYEMCLIAGIAHQYPAVRKDKIVTLINAYLLREPVQRPTPLADYVDSLRERCKSEAASASLATPTNTASKASPVPSGPTSSAASPTSGKSSTSLPANYRVLCLCVYKSMLLANSESKEDRKAALEVIKAIQDTPQYKDRQWSLSYAQAFTLYDKAYIVYRDESHEEAESIMNELHKQYDSAHYFMHAKMDLRAHLASYHLQEERQARAPKHTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RP44</accession>
    <name>A0A088RP44_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_161540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN97029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697682.1">
        <property type="nucleotide sequence ID" value="XM_010699380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RP44"/>
    <dbReference type="GeneID" id="22573733"/>
    <dbReference type="KEGG" id="lpan:LPMP_161540"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160020800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_161540"/>
    <dbReference type="eggNOG" id="ENOG502RYG8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="17927at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027536">
        <property type="entry name" value="MDM34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28185">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28185:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="341" mass="36330" checksum="BD5804386E125591" modified="2014-11-26" version="1">MLRWDWPQTWSLENREAIRVALETCIRGAMAKGESKVVRGLVHVELPEIGSTPPQVMLTGIRELSLEHTALMVKVRYDGEFSLKLRGLQVNIDTVGANSTLSSDLNLAMPFYCPLEMTLSDIHVDGVASIEVFQEIADVANSEDASLLSPDFTMDLIGSSRTGGAASLSLLNRVPRSAPSPLLSAVQSSVGRSARTGGYPSSGYGVLLGAGGRRTMRPPAQAQGGHAPVAPLAFTSPNNNSFTTTDASVAGSSGTRSSAGLWAAPSQPRHSLIDLASKRAVVKKRRIKVQLFGDPIKRYKVESNLVAVPGAGKKVEAHIQDILAPLIERLMAEGVTIELSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RP64</accession>
    <name>A0A088RP64_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytoplasmic dynein 2 heavy chain 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">LPMP_203930</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Cilium membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dynein heavy chain family.</text>
    </comment>
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        <property type="protein sequence ID" value="AIN97887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698594.1">
        <property type="nucleotide sequence ID" value="XM_010700292.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22574604"/>
    <dbReference type="KEGG" id="lpan:LPMP_203930"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200045400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_203930"/>
    <dbReference type="eggNOG" id="KOG3595">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10252139at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cytoplasmic dynein 2 heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000706">
        <property type="entry name" value="Cytoplasmic dynein 2 heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
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    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
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        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.10.490.20:FF:000004">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000598">
        <property type="entry name" value="Dynein cytoplasmic 2 heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dynein heavy chain, putative"/>
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        <property type="entry name" value="Dynein heavy chain, putative"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054354">
        <property type="entry name" value="DYNC2H1-like_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049400">
        <property type="entry name" value="DYNC2H1_AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
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    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
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    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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    <dbReference type="PANTHER" id="PTHR45703:SF22">
        <property type="entry name" value="DYNEIN CYTOPLASMIC 2 HEAVY CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="AAA_7"/>
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        <property type="entry name" value="AAA_8"/>
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        <property type="entry name" value="AAA_9"/>
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        <property type="entry name" value="AAA_lid_11"/>
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        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF22597">
        <property type="entry name" value="DYN_lid"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DYNC2H1_AAA_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
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    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-0966">Cell projection</keyword>
    <keyword evidence="13" id="KW-0969">Cilium</keyword>
    <keyword evidence="9" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="12 19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11" id="KW-0243">Dynein</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="15" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="20">
        <location>
            <begin position="1648"/>
            <end position="1794"/>
        </location>
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    <feature type="domain" description="AAA+ ATPase" evidence="20">
        <location>
            <begin position="1944"/>
            <end position="2166"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="20">
        <location>
            <begin position="2256"/>
            <end position="2404"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="437"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="1003"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="2843"/>
            <end position="2888"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="3055"/>
            <end position="3124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="AIN97887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="4247" mass="478756" checksum="B9EA93B6909A2732" modified="2014-11-26" version="1">[encoded data, 4247 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPH7</accession>
    <name>A0A088RPH7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AP-1 complex subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_203740</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_010700273.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A088RPH7"/>
    <dbReference type="GeneID" id="22574585"/>
    <dbReference type="KEGG" id="lpan:LPMP_203740"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200043500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_203740"/>
    <dbReference type="eggNOG" id="KOG1062">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017107">
        <property type="entry name" value="AP1_complex_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037094">
        <property type="entry name" value="AP1_complex_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GAE" evidence="10">
        <location>
            <begin position="720"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR037094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN97868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="833" mass="91651" checksum="5880A3D33D690BCF" modified="2014-11-26" version="1">MSSMDSMRLQASIRLIRQCKTTEEERSNVKIISAQLRKGFADAKPYIRVRYMLILLYIRMLGYPTEFAHMEVLKLLSQTDFSGIRIGYLSLQLLFNEDHELLTLVENRMLAHLSINGSCQSISYEQLCLIGISLNASANIASEDMCRDLLDSILRLFQNSPQQLRSKAALAALRVVRKVPDQAGYILEHCTDLFDGNNESLMCVLTLVIECLQSDAGANMIGTFRKHAMGAVRVLKGLVLSSRITEADVSGITDPFLQAKLLHFMRIIGAGSEVTSEALNDVLAQVITNTDATHNVGSAVLYECVRTINAIESDGGLRTLAVNTISRFLSSVKDNNLRFVGLQTLLTYSSKDFDAVVQHQAIILECLRDTDLSIRRRALDLTVTLITANNVRLLVPDLIAYMSLCSEEMKSDVARHICDVIDTHYPSEMWRVDYSIRFLKVAKQFAPLDFARRLLVVLLSQTKDVQTRAVEALWEEASCPFDGRHHARKAFLMVALWCIGEYVELLLDAVKGLTGADVATCLSSLTTNTTFTLIKQYGLTALMKVATKCPDAKPQAMATFASNMTSMDCELQQRACEYTSLLVDFPQEAVFSFSQMPAIAPKTEAVKPVEVVTLTEMQLLQETTNTLDDLFNFDGASKPAQLPPTRDSSSTMVALSSQAGSLFSACCDAPPVPQRAPSNANTFDDLFGNSNAVSVPAACESPPVADRSIKSELASPKGSRGVTGVCAFNCSDFKVLLSGRMEGSIIFADLVVQSNLNEAVEQLSFSVATLRMCTVEVAPLPSTMMPYGVATQQLKVDNTQNTANPRTLTLRVRISYAVHGAPREQMFEVSQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPR1</accession>
    <name>A0A088RPR1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_180230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697857.1">
        <property type="nucleotide sequence ID" value="XM_010699555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPR1"/>
    <dbReference type="GeneID" id="22573913"/>
    <dbReference type="KEGG" id="lpan:LPMP_180230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180007300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_180230"/>
    <dbReference type="eggNOG" id="ENOG502SHC1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265097at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="404" mass="44721" checksum="43B283486F4EA97D" modified="2014-11-26" version="1">MFSARHIVRYFVDRHTVAVMAAFVFYVFLLRWCGRIGVREVQQRAAAVARPHRSILDISAFAGPTFSASVLAQSVSVAVLRLSNADVELLHGGPLDRVPSQVERQQQLLALSSRWQYYFAVGDFTLVSAPARLTSNGMLTEWITKLESVYPTCVFASLTDSTEADATGDERRLLILPTTWQSNRRALGGQQQQSLRVLLLETLPTLKRLRETEAAATAAVDASGGVAKDPLFVFVSENATRRWSTAIDAAELTRPPAERWRSGKSSLDAWEEMLQTTSMPRAALRAAVAASAMPPTGEDPPVSYRRRLLAHLRREKAQAPPPTAMADAAQYIPRLAVHLADTYGAPYVIFASWCSSVGTYGWTATRRLEASSEEQALVLVLCLHENELVEIIPSRQYVSRHIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQ21</accession>
    <name>A0A088RQ21_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Metallo-dependent phosphatase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_204610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698662.1">
        <property type="nucleotide sequence ID" value="XM_010700360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQ21"/>
    <dbReference type="GeneID" id="22574673"/>
    <dbReference type="KEGG" id="lpan:LPMP_204610"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200052800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_204610"/>
    <dbReference type="eggNOG" id="ENOG502QSAS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1883418at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34211">
        <property type="entry name" value="CALCINEURIN-LIKE METALLO-PHOSPHOESTERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34211:SF3">
        <property type="entry name" value="CALCINEURIN-LIKE METALLO-PHOSPHOESTERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="838"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="888"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="933"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1060"/>
            <end position="1085"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1212" mass="135841" checksum="2549BD1922E6F65C" modified="2014-11-26" version="1">MEALLLGTSRSEWYERVQVFLVLATERMMSLQSGIFWTFSYVLLLTLMYLFHSPFRSQLESRTDWYAQLTKGLQIWLAVVLLCFHVGPHVVESPSTAAGATGTKSMASGATQHILAEDTVATIFFPTFCFSSSFCLLLHKIKRRYKLAFTYGASLTVVLINSVLLSSFATMHYTTCRELFSTAETAVKASEKTRTTPAAGSLTLPLVWKRTSLVVCPQPAKEKPFVCIAFLCTLCVTFVGIDYLYKKHVAGGDPLRGILWADLYPEKQKSYNSSLASSSRTPFIFRCWGWRRAHVSDNHAAERLGLSEGDPRLQELTPKTIVVPSHAKHASRCGDGDTDPAGWQDEHDRLSVSDGKCVTHPTNRPGMVPWFSTFIIRTTWQVLARMSLEFLTFDIRVLQHYARPKVFELHFESSLKDLPSFRMDSERDSMYANGKPTAADAATLSATCPPTPLQRDATQALKQPLPATSPEKRVRENDKDIWFDWISDVGDGFNPTYAMARLLARPFLKLTFYHPPSRRVGLSLFPTYEEVTPAKTPSPNSAPDVLPRGSFVLVGGDLAYPSPNDETYTTRLFEPYHDAMSGNVRLQSVFHAEQQRVIVADASDADVAHVHLLDAETVSEMATGRAALRTGRATAEEALRSVPLLFAIPGNHDWFDGLTTFHKYILERTWIGGWLMPQRSSFFVLRLPHNWFILCGDTGNMQDIDVAQRNYFLDVIEKYMDVESCVILAAHEPGWVYDSMLHKPKLAQPELSKVCDALGTRLRLRLAGDIHHYSRHVPVDASSEAATLVVSGGGGAFLHGARNDSIISQGTKYVRACAFPEHNTLPTMLNRLLGFRVINWKFDLIIGVCSFLVVVSLLPQSIKDVRCDLESGPLMTLPDAVATWWERVCVYIVTLFSKGIASLLATLGFLAVFASAGVEKDIPVWMRLLHSCLWSFLTVFICCGMLAYLICTLQYMAENHLLVSADGHWGGVLEDQVFASVDGLLNHTKELLGGPHASVIAHELHRLQTSFYGGRLVSWCGVILRCLDPFEMLAYLSEKVSSPEMGTFAGDASRVDELLYYLYFVFFYWTLVTPLVSFVIGSYLMCCVTLFDCLYDAAYSAFQIEEYKHFVRFRLDVATRELHAYVVALRHVPKSWTWDSTYQAELKGDAVRAAPPHLRAHPSRWHGKHFRATSRCDDGKRAAFDEGVEEGVEILEHFVCSPHRLPMPMSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQ25</accession>
    <name>A0A088RQ25_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">N-acyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_210760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698864.1">
        <property type="nucleotide sequence ID" value="XM_010700562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQ25"/>
    <dbReference type="GeneID" id="22574898"/>
    <dbReference type="KEGG" id="lpan:LPMP_210760"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_210760"/>
    <dbReference type="eggNOG" id="ENOG502RQIP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2122564at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008914">
        <property type="term" value="F:leucyl-tRNA--protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.70:FF:000006">
        <property type="entry name" value="Hypothetical_protein_-_conserved"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.70">
        <property type="entry name" value="Leucyl/phenylalanyl-tRNA-protein transferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004616">
        <property type="entry name" value="Leu/Phe-tRNA_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042203">
        <property type="entry name" value="Leu/Phe-tRNA_Trfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30098">
        <property type="entry name" value="LEUCYL/PHENYLALANYL-TRNA--PROTEIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30098:SF2">
        <property type="entry name" value="LEUCYL_PHENYLALANYL-TRNA--PROTEIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="366"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN98157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="379" mass="42823" checksum="6E7D400B5A284443" modified="2014-11-26" version="1">MHATYLQRVTQHFREDKGKEFNIEAEVSYASQATDVRHLVPLTKVDIQHFSNFFPPVKSKDDLETLPAKLKGNEELGFSPLFDPSLIDACCQRGIFPLAVAISENIFLFAPKLHMERAICALVDGAAQRNTISGFPFCEGDEGIFNKDSLGVSRKLTKTPNESTHRPSFEIFVNRQADLVDVFTLIRRQHGENWLCAPLRVCLLHMFFNPTKYATKIIITAIRYRKYNEMPILESSPLIQEGELVACEIGYLVGDIYASATGAYCISGGGALQLSLTGVCMKSAGCRLWDLGMMMSYKRSLQCVSLPRKKWQSMVSVRRTNPNEHILRYLHDLEKGLPVSDFFKTAVPPAIADLNSKSQRKKRLKKEAAIQRKAERMRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQJ6</accession>
    <name>A0A088RQJ6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleolar RNA-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_200170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698216.1">
        <property type="nucleotide sequence ID" value="XM_010699914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQJ6"/>
    <dbReference type="GeneID" id="22574224"/>
    <dbReference type="KEGG" id="lpan:LPMP_200170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200005300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_200170"/>
    <dbReference type="eggNOG" id="ENOG502RZ4K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273406at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019186">
        <property type="entry name" value="Nucleolar_protein_12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09805">
        <property type="entry name" value="Nop25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="245"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="285"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN97509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="332" mass="37543" checksum="F73ACF88401CE1AF" modified="2014-11-26" version="1">MVKYVDAGADVAAGGNKKIRKGFKSDRLENYKRMLVKKNGKAVKDVPTRTVRPKTLTFDDSSRRDYLLTLHKKKNERRVQAFVDAKRKQRKDSAKTRREQREEARRAYNNYARVPILPDYTYRLPKLQDDRFADDDEAEDRGGESDSNTQGKEMREEDADMSWMSVDDPEAAADVANFSLATEASQRRRRAKRLATLPHSTHTMPGTMMNQEVSVAADTHCSVGPSSSGGVDSEYVTVEVKPLFSPSSGGATSTGKDGAASAKTLPSTNFDDLPFTVQQELRRLRQEVKGPARTKPRLRMMKELEKIRKIRKHSRKGHGKRKASGKRKNRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQP5</accession>
    <name>A0A088RQP5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_200570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97549.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698256.1">
        <property type="nucleotide sequence ID" value="XM_010699954.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22574264"/>
    <dbReference type="KEGG" id="lpan:LPMP_200570"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200010000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_200570"/>
    <dbReference type="eggNOG" id="ENOG502S6I3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="191673at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048732">
        <property type="entry name" value="CFA69"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14716">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14716:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97549.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1792" mass="191853" checksum="656229A13B600B92" modified="2026-01-28" version="2">MHGCVAAIAKGEFGIYENQRSNEREHRIAAVVASLQSTQSPGIMCGSTSKSERQCNDAAAVPINSLLPPLIDQPAKLWSDTRDDTRENATEDVRAATAMEMWENYTTTAHATTWAEDTMGMPRAAATAATISSGASSTNATHSFTPAVAAATPPLVPLSAPVVTLRSFPGALCALIERCTATPLVCLTLSDQQCQVAAVRDLLRALLTIMQSIDANSVSTTNCETTLVSHSLSSGQHTQVAARVALDLQALRLAALKGVSQVLSTYLDGADGTAQAPESAPRHRQQPGMAQSTKESEALTAGLDSLDILSIFEDVTHQWAHALTALATDKGFISDSAGVGGGVDVAPRGDRFGAVGSPPGHRSCEDGNGAAAQLHWVLRVTYQIIAAEQLETRCATSLATPRARLLPPLLVPLALRTLSLISTVNPLACRTASYVQSCVDVLWGASLLAPGESARQLMYGSMGDSGLAGASSDSYKGGAGISRGADASPPAMDLFLTLLHQFNEGHSAAHCELRNNLVCLLASLLRYDIQRVEDALVARRGAQDSIRRTALESLSYPSTSPPSVEAHDTPLTLNVATVEAINAVAALLFEITCGTELTTTTHSATTTAAAAFQSSGVDSGESVPVTLLSLDAARRHALRFQSIVTSVARRREMLDFKIYGWQLLTAHCDWQLAHLTYREYIRYHDPAAPAVDTAPDSHHQCVSPVEQVIGEDNYDGAVTAALCGICLSQVGFLDVLIMYVDTRTDEVAVVAWTQEELLQLEVEAWQLLTSMILFAQHLDTKSGGQQPRCHCRYNRKLSVAQQQQREGSPLLRGSVEAVEKRHFVEDAEHGDRDMDSVDTAKSGILYGAGKHFIAAGGLQVALRYLHTAPPEAEAVKRWALITLAAVARTSSTDEAHGSSGSYTNQELTPVQRALAQHAPSLIPFLVKLIREVDVYVDTSGVPAALPPLISSIAAPESATTPQHSLGHRSVRENNGTDVTAATPIYDGVCWNWLPQSVAHVTLAAWSLLRCIGDVLLAEAGSVRGLALSIMNEDSIEEGDPCHEDEDAATHEPRPAMPVDATSGTASARGRECVRSDRASVRSRSLEERQPHDEVDLPIFIMSSSGSSMGSLVENGDNAVVSGHGCPAARSPHRVSAPSHTRALSCSAHSPVLRIPNLFAEQGGVDLLTSWLRHVMRLCLPAHLQQQQQQQQRSSAGIVPQLTMEEVASLENYDNTFLLLLDVFRAIVMGCKANEMQFAESDGVHVMLDLMEAYALAHGLIDQAARHARLTVVDSFGSAAVQTADHKEQEGVLTYATTLLSDLLESCPRAIDSFSTWRSSRIAVSPLTPDVRECQLPSDGGIEAVQLLLCLWASEIPARECGGALGSIGTALASTSGLKLLRLHLRPAVRMALKEEYVCRLLHRHVELGVLQAETIRNYYLYLHSEVAPATASLMQAGEVTDAAVLAYMEGLISRSSRRSAVTLEQQIDLLLHHALGLCVKVYACLSTIGFDSLRTAEAETLTTPSMGLRLSSLERSFLVQIAALPALCVDEISVAMAEVSLEHQFSADAAASKSSDPGAHDGNDAATWRPTTPDRRVLCTAAQEAAVRAGELDQLIEVGAQVQHARELQLYNRFLVTQLRQPVGRPADGRPGAVKGLWKTQRRLSATCGSGLGGSGDKIVFSAAELAVRLSTRLAAEHLQRQQLIASTVRVTQQLGGTQVEDSGGEVQSRASPPSNAPFVLGSSRTPYASIMGSVSAATHERLPDTLFSVVAPPKRPSVSLPQRHQQRQAMIARSLRKLPQDQPTSQSPHKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQR8</accession>
    <name>A0A088RQR8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_220180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699020.1">
        <property type="nucleotide sequence ID" value="XM_010700718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQR8"/>
    <dbReference type="GeneID" id="22575064"/>
    <dbReference type="KEGG" id="lpan:LPMP_220180"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220007000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_220180"/>
    <dbReference type="eggNOG" id="ENOG502SKKP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273246at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="19"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="199" mass="22029" checksum="962FCEB292632BD1" modified="2014-11-26" version="1">MNTVQSYVHEGQRIASEHKAQLQDAVKKAVNVAQEYVEDARKKADPYVESAKAKVDSAKASVESARHSAQSAVDNAKDQVTAVRTRVTEKTQPYVNNYQEFDVTKTAAFHVLIHLISSVLYVVWRLTQLIPFAKQALNFLQQKEADAVVVHSCSAMVQRVPVVGPRCVEVATIVVSNVYTGLNEQISQYNAASQRKKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQZ9</accession>
    <name>A0A088RQZ9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_221100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699110.1">
        <property type="nucleotide sequence ID" value="XM_010700808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQZ9"/>
    <dbReference type="GeneID" id="22575156"/>
    <dbReference type="KEGG" id="lpan:LPMP_221100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220014400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_221100"/>
    <dbReference type="eggNOG" id="ENOG502SJJ7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275074at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="163" mass="19437" checksum="039781FD75D0C000" modified="2014-11-26" version="1">MLRQTAVQLNTYLTRSVATPPISVIRTGPKWWAEPERMVKHKVMYFTMGIDQLPLRRTAVIQNDLKRFHMCKPPPRVGDATGYKRSRGAQLTTWYRRIQYQEYHLQHLFVRHMWGLLRMYPGNTTKIQGKADDGYVGYDSVHFHRYNRSPLPFPAREIYERRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RR26</accession>
    <name>A0A088RR26_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine-threonin protein phosphatase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_221380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699140.1">
        <property type="nucleotide sequence ID" value="XM_010700838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RR26"/>
    <dbReference type="GeneID" id="22575184"/>
    <dbReference type="KEGG" id="lpan:LPMP_221380"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220017300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_221380"/>
    <dbReference type="eggNOG" id="KOG0374">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46546">
        <property type="entry name" value="SHEWANELLA-LIKE PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46546:SF4">
        <property type="entry name" value="SHEWANELLA-LIKE PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="39"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="361" mass="39759" checksum="2B4E3BF1C55A4E01" modified="2014-11-26" version="1">MRNYVLRVVRCYGALLVSFSLLLVSFPVHCERKLVEVHRIIAVGDVHGDADNFLKILRIANLIEDSAAGASDVLDSPPRWKYSSSQISDTTVRTTLVQVGDLIDRGEQDLETLNIAISLQEQTAQSGSQDKVVLLIGNHELLNLQGHYHYVNEKNHGGFMSKALRAEGMKVTGVFGKYIVDNFKVAHIDEGVLFVHGGIETGMNIKDVDALNEDVRSALRQNIFRHSFLRSSGPLWTRKMIMASMSDECADVEAALKQLNASRVVVGHTPQESGHIGQYCGGQVLAIDVGISRWMYDRAVALELVFLKYTDSLTGSSSSNFVVSELREGVSGFCYTCVEARDDTDSPRGGGSVEKDTYDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRP2</accession>
    <name>A0A088RRP2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_241450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699484.1">
        <property type="nucleotide sequence ID" value="XM_010701182.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22575554"/>
    <dbReference type="KEGG" id="lpan:LPMP_241450"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240019700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_241450"/>
    <dbReference type="eggNOG" id="ENOG502QR71">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="851"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="323"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="514"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="777"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1405"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2449"/>
            <end position="2483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="515"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="787"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="799"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2457"/>
            <end position="2471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2905" mass="304529" checksum="E037B8EA2A7242D4" modified="2014-11-26" version="1">MERSGFGDAFRCGNGGGRGGAALLTNESSSLQRTAKARAHAAQYLMMGVDNAFMPLLPDHPGKRISLHRQLRGRYNPTQIPLSSLSCAAYLSAGDVAQLATLFHQFSLFSSEVANTLDMDDSSGSGRNHSSAEGKSGAAVSATAMARLAKATKSRPRSPGRGNEARLQPSPGVCTTAAAAAPPPVAMDVTHGKSGMGLVRCVARRPPPATELPESLRPASLRGAGVVAAAAGTAVPPSSFATPSTVRKEKGKLVAQTPIKMAAAVDRGELAEPFTSESNDAALTTGWLVELLLEMVIENSARSACVSGGGAGAAAAAAITSGQSPMPSAESLPPSRSGAGSRHPYKSGSVAPAAPMGFNASTTLYQARRREARVDELLHFKAELTAWAEHLAQNCEQCEHRAVWQQCAAQDELLQRYQACVLHSQSPRLAGSSLASAPGVTAAALSSHPKIMSFENFESAGVLMSSKAGSNVSPHRGGGAGGRGNVSWGLPHVVDSVLQNVVMSPAAHGALCSSPRGSTAGLTKPTTDPQSHMTPTSVRQQLPGIATRSEISDADEMPSMHNSDSGDGGLVHASSPGEILQSTVSSFTDSMTLLSSNAAGVVASVAPPFVNAPAVGLSGAAADRSLIAVKAWLTAPALKDLLPQPAQLYAYLWASSAAARLAEEETRDIHHHHRCVRMARGTQLLPGNGGDGYAGGSNASRAGSAAGARRSRAAVVQYLVCWSDVASNLLMGLETTCLSQQQESSYARVPTALLEDSAEMAAPKTAGLGYHIDTAPPLSIGAHEDKGDDDSDSLEDDMAGGGGTGVAGNGHSCRRRQHKSSFGNDAVALQQRAILFSSLGAAAENTLDVLHREAADHILASPTQCYTVTSSKDGLLKVWDTSCGQFVSTILNIGQSWVLTMTFLHGGEFLMVATSAAEITVVNFPAGGVLLKLRGCTSLATAVPQVKQLSTFFTKRYGLKPGECGQHKPTDGDGGGWLGAAAAARLMECADGDGEPIVARPIVGYVTPTAAFYDAEVGFFFFGTMSGMVGCIDLTAILSRTALHAAAAGAGWAYPLQVYDSVFAHLEVLPPEVDATVTPAQEMTLSSLEAAVMHSHLPTTDRRKARAPLALSVAASSRGVPVNRLFYCGVGHCIISSDPDGGIVRTSFTADADTLDYTLGTPSVVMATAKPIRFMVSCSRGRRFVTVHRDRRAFLWTVGRTLTECVHQYPQEAYDIIDACFMPPHQQVAMLMADHSIRIYDERGSRPLTFIQPPRGLSSRAEDIASMTLKCSANDVDGCLTYLPTTQRLVCGLRGPVLYEPAGRAPTRGAASTGTVMDLEMLVTTDAREGKNLNPTDAAAVSSTAGMRMVEVHSPSAVSLSLESSLSLPPLPQSILSFYAPTSTARAAMQQVTILVSRHPRNVSASVSTDSSAYGGMCGAEDDATSTETEKARTAAAAAQKEKRRQRQVSATLQKCHERLRPYQTHSSAVIGLLLDPERGELHSFSTDAWCVWCYETGKRLRAPLHVPSAAEKELAVRSRRTLLTCCSWSTEGRTRVLVGTRDSRVLTLDARVGSVMSTTEPFTQSARGPTAGASSPILLADRDVGAISSSGNRTLLCSGHVCEVRRYEVTSAPQPSGEQKFISMRVELPSATSAVTGSSTHGGGTATTIVPAAAVAKDMKGTTSTARGGCSDTTITACCVVRESHLCLGTADTQLFFYRMVDRSSPVHVEVLCDAQEVPDVGRVVGLNYLNNSTHDMLLAVVDTGILFLYSYTLQRTLGRYSFPLLGKTVFPAVPHACTPRAHTRAPQQQEHYITSVGLACEVIGAPQSSLVIMACGDSAGYVHVVPLAHMVAEASSTLSRERGVSGAARVPRAHKLRVAASFRASRGGISSLELLAVNSSKPMVGMHSYVATTPTSPEHILADKGGRPDGPASTTATTMATPPNARFSEPFLLVFAAGFDGNVRIFSLSISALQQPDVLPVFPLTLTTSTSAWSLPPTQPQLLQSTTASASCTRASLNRAVLSSQPGCSSSFHTVGGRRASLLSHASGAMRYEVTTVGLCGVDTWDLCDPRTFSDVEQAMVMTQARSDGHVGVVLPSILDDVDDRESNAEGCGVAADNDSAREDHTAAVGVASTIPGKGTGAVLLYDILRKSKKQRTGSSTAAAGANVQPLSHQPRLAATTTVTAADGAALRQCGTAPGSQPLPPPPSTRIASPTATAAVAGALAVTARSRKDDACANNEPVRSPGWCASAALPSPFLPSPPPVQFMPHTIEELVRDALPSSWSRSTTMRGGAAAFSSLFDFPLHNAADDMRDDSINDTLSPTPSPREKRNPLVRVYPLTLLRRMGLLHPLDTTPDIDPVTGLPVLISACEAFKPWEAWLLGMGSVSTAATSTVHMSTSLTCSVKSVPPPLPPTEVSAPASAVALRGTGTVINVPQRASAPSSSCSSSSSLPSGLLWPRRITVTASPTSPSLIPEFERSAGEEVEEGRRRSSTGVDDTEGGVSVFLTEGGVEWARPKAFIETNTNPLPSLSGTPLTKTAAGETSFGLHRTTKVGERTIALGAEPPQRLTVRDSGEALSRQSISSESPSTALAWSSRSRPLFFPPAPPTPAQLLESQKLTYLRGVLGSVDADVLRMREDQMMLVHMARRLDCSRQAPPPACAGTIPTSTRGIPAMGEYTSRLMRLWRQRAGDTAAATVAAVSALGAVATAGTPGTAAATEEEGATNNARVATTAARVREAKPGYGSVPTRGLKGSGNGALGKAMVAPGQREPTVMLSSSRSMRQSTHESQSNSIAAYASMLQASPPTTFGLDLLALSLPNEPQAAPTRAQHRTSRGANAVLSARAAASPSGRGAKAAMSAADGTATSSKAIPHLEARLPMIAVQQEVQPIRVNLPSTLRRDEGERMWLRRFEAVFNSVDSGNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRY9</accession>
    <name>A0A088RRY9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_240050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699347.1">
        <property type="nucleotide sequence ID" value="XM_010701045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRY9"/>
    <dbReference type="GeneID" id="22575414"/>
    <dbReference type="KEGG" id="lpan:LPMP_240050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240005300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_240050"/>
    <dbReference type="eggNOG" id="ENOG502S5WZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272363at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="466" mass="51965" checksum="B358CEF0BF3E5DC3" modified="2014-11-26" version="1">MIRLLALLRCASFGVREDRQALARHHLSLLDKRHWKLTTPSRALPVVEVLMRSGVLMDRLEKSSTKPLACLIPSMTKKERSLVEKLSYVLHQNLPPTASPIDRNARREDETIRAAYSVACATGTCTIDVLVDVIFVRHLRSPSSALMLLELVVSRCAKVSWTRGKPCPSKEMLDSICDLLAQHEQSLDFRAIWFLLSLLSATPQFSDSQITPSAGKRLFRLCVHRIHHLLPLLGVEDHLLAYLQLARIEGYEKPFIVLGEIERLLLSTSLGDYTGVSTNVLLRFMTMPFAARHVDLNLRLCAGWCAVSRITDFTQEECLAAFTIVAALHEGCSAESATAVAPLRHWETLHDALFAQVFFIAHDLTAADCFRILDQSELINISGWGITVPQMLLEKLKKRILSECKRCAIDECCAPETAELLLCVALGLQSLMQRYTVLPSNAVDEHAVTECIALLEDCITLAPPHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRZ6</accession>
    <name>A0A088RRZ6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_241100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699450.1">
        <property type="nucleotide sequence ID" value="XM_010701148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRZ6"/>
    <dbReference type="GeneID" id="22575519"/>
    <dbReference type="KEGG" id="lpan:LPMP_241100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240017200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_241100"/>
    <dbReference type="eggNOG" id="ENOG502SJZP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="249522at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="607"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="816"/>
            <end position="898"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="947" mass="98492" checksum="28734CF5955F2CB4" modified="2014-11-26" version="1">MADIGLPRNPFESHSDKGSELAGETLQLISAASGEIAGNLSSAAGAVSVTNRTLTFPVADESDPLALLYSTPAHKPLSLARRTCGTEPLFQYYVLRGYKEILSESETLKAAKAVQACLEDGDAAAAGSGMAAAMVQRRLSSSKKSAPSLNTSTIDKCLLSIAAAAAPTAVSAAGLATDGATNSVVPLYLPLRPTQALDVSSSYCTQRAEEMRAAAEQERSERLRLVPEAAVYLGRYYPEDSHIVADVQLQLAEENCDPVANAGTTAKFSVNSSNPPFIFNVAAVGTSMLARSPALDSVPLPIPNTPAGGTRFLSSLGPSRHLTAKEPGRLSAPSIAPLLLRTPQEAAVTMQMQQEGRHVLADQIEESFVNAYHLRDPAAAQRQRDRESLSVQRHSMQAAAALRAGTGSAATAKKRSILTSSKKLGGKARKLTVAPPKREGGVPANLELFRTSLLLACSEDGAVTLGQLRVLLAGVPFHVGTLTSISAADLASVAQRLFHIIHSSTRACNAADATDLLLAFASAATAGCGGSSSRLGNALGDSLVPTAAHAPGNSLSRVSNAGIGARRGVGASATLTTAGQMRLSTVSTQLLASNASVISPIIATADAGGSTSGGAHTPKTPSLMGGTAASCHEASGAGNGRRQSLHHRPSADMHDEWKSILVVEVLDALDALLNSVETKRVVRWECFNVLAAEGNGYIHKSQLAKLRRHAYRDGSAAEEQAAVTAAMVKALSDVFAVVATEEEAAYIKANKKRKKKGGAVALAAHQSSPIPLNVMRKSHIDYAVFCRFFDEMPLMSAAFAHVWLPLLLNGRRHTTAAGGTTVSPSDAAKSSIALPGRDSVTGTTSLLPPSPGSSAEALDDKDGEEASPNGGPPPSQSQRRAAPAAEDDPNASPLELLGSTVDARQAAVWQLVTDRQKQLHQACDAAEKEKLALLQSEQGSGRAVADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRZ8</accession>
    <name>A0A088RRZ8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enkurin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_240100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699352.1">
        <property type="nucleotide sequence ID" value="XM_010701050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRZ8"/>
    <dbReference type="GeneID" id="22575419"/>
    <dbReference type="KEGG" id="lpan:LPMP_240100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240005800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_240100"/>
    <dbReference type="eggNOG" id="ENOG502QT8E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2123594at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027012">
        <property type="entry name" value="Enkurin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052102">
        <property type="entry name" value="Enkurin_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21490:SF3">
        <property type="entry name" value="ENKURIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21490">
        <property type="entry name" value="ENKURIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13864">
        <property type="entry name" value="Enkurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51665">
        <property type="entry name" value="ENKURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enkurin" evidence="7">
        <location>
            <begin position="177"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="93"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN98645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="279" mass="30863" checksum="D20DD026384C369E" modified="2014-11-26" version="1">MSGECVYDLVTASSSSAADGNVLRVKPVATAKKSRRPPPPTASTFGIHGTSAVVGNAGGEYTDASVHPSRKPIGTFGREVGLTVTPEHFLRKNEGPLTASRGAPTVDNSTFKKSDCHHEKTKPDVPLRTERPVMGLRTEKNFVVANAVENTMAVPTKVMPAPQPRATDREDFGKVPQYITEIKGDLNARKQMLEDLKAADRGAQERWSEISLSELAQLRDGLQRRWDILNKDYQTKGFSKLETPSQRAHQELVERQLVAVEFAMQKLSRQHVFVFDDQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RS35</accession>
    <name>A0A088RS35_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_240410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98675.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699382.1">
        <property type="nucleotide sequence ID" value="XM_010701080.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22575450"/>
    <dbReference type="KEGG" id="lpan:LPMP_240410"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240009500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_240410"/>
    <dbReference type="eggNOG" id="ENOG502SIJI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265640at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98675.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1331" mass="145878" checksum="8F88C8B41B30AB1C" modified="2026-01-28" version="2">MRRLVPLHITSSPLSPCTPLFLSSVVLSGSSTYGNVHTSSPCHTLTTMALSAASSSDALNNCTSFESESELSLAQEDLKQLQSSLQSTRSFSEVPASVRTRHTSTTPPARTLPPRLPVSMKAAASSSMLVKPLQMTTSVAPGPPLQCPPQLVVRPQTIVLPALLQRPRWHNVVHERYRASAPGYVDACAQVLRDIHSMWEECMLNRRRREEGVRGRQGDQGKDDGDSCFAEHVSELLFHAHTDALLVLLEGVIGIHDGGDAFADSTAPFHCKLILHLVDRLARRTVELSGKHMAHLSHLLLSCPSLLTVAPSAQNSHAQALTAAQQEDVWNTFTFLCYATRRNLRRRQNVDSLEALLCGVYMRIYNDSSTALSDDRGNRASRLASSMRRCYADAVDGGQQRQYVCHLFPPGLMAKVRQAALCHLVHRCLFSGAPAQVGAAEAITEERVTQLLAWALLLAPKDMGPAVHAAVVHRLRRNTELAGGGLTAGASPVYVESWRRLALRVEAMVPLYRIGGKRATASPNGTEVFQRLHWAFKDTDGWAVPSADRLLLATVQERSLAQKYSSVPPWRATEYVAPRGVETARLCSGDAAAQRVANGAAATLRAYAFLRWEPLNVSEAEQLLPNDAPLALSALHMERARRETHASIVERRITKVCEDTIETAAHLPLHALCLAEVLCVRLLRSLHRWRGTSTDDIIVPPASSGAAATSPAIIGVSQQRRILAALRQLLTHLRAEGAMIALLGLQGEARNTAATGRCSSEHIQRDPSRTAPPSAPIWPSMPQRTWWLLSSAMCQHAEDAVRAAREWMVYREMMATPLSLASVQRVCEWLVALPGPLHSSQLVTVLREWAEMEKNKLNDASSLGQECLMTWDDVVRTAQEQHAAQALLAVLDGQCTIADATAAPYCSPCGEELRRTYAIMMGPTSAQLRRLQWIAEANSSAVREWRWNVGVASPQMGRATVSRPAGLLDPTSAVPAAVLLVEATEVNFTDTEHEAAVRLLRWRCLSHLSSPNTFSWSDRLACRALQSAQAVSSPTTQLVANSDEVVISDRSSAADGDANALPHQWKHDSDTIVSAAALHYLLSRWNRMESSAATITAMFSTAELNDALQALAVYVEFLEKPQNDGVNEGQCGERARIRRLRCAAAAYVDCLSDAWRVTMQTAASTTTTPSLGRVDVKVFLMCLPTLYQCALEMHDRLLRNKAELGNGDDEVLRSLPCLSGPLHEAAFRALVDSPETQSDTIETTLLLADHITRRWPVRTKISPFSSRRAHSSKALPLSLSDGAPTFSVPLSVYRLVLATYAATRTPLPQRIRVCCEAALRRERKRVLEEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RS75</accession>
    <name>A0A088RS75_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nuclear cap binding complex subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_251240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699694.1">
        <property type="nucleotide sequence ID" value="XM_010701392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RS75"/>
    <dbReference type="GeneID" id="22575772"/>
    <dbReference type="KEGG" id="lpan:LPMP_251240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250018100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_251240"/>
    <dbReference type="eggNOG" id="ENOG502QPYG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277260at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048321">
        <property type="entry name" value="CBP66_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048322">
        <property type="entry name" value="CBP66_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043965">
        <property type="entry name" value="CBP66_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19043">
        <property type="entry name" value="CBP66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20991">
        <property type="entry name" value="CBP66_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20992">
        <property type="entry name" value="CBP66_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear cap binding complex subunit CBP66 N-terminal" evidence="3">
        <location>
            <begin position="2"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Nuclear cap binding complex subunit CBP66 second" evidence="4">
        <location>
            <begin position="109"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Nuclear cap-binding complex subunit CBP66 C-terminal" evidence="2">
        <location>
            <begin position="192"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN98987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="624" mass="68446" checksum="875CD06A4876A26A" modified="2014-11-26" version="1">MRTFVFISGIPDFLLESIVKGDKSSNGVATTKSAAVTSKFDLRYERLRRLLVEHSSGVMLVMHLESKGYALALYASEREALAACKADITPEQPGRKYPPLRLRIIEKEKPCPPEPVYNPYLIVEGEEVRKEELADTRGLELVYRGRAVAKWCARTLAGEDCYFGVSCLKLHKNATQRTVRKRPRVEDVDVSAHLTSEQQATVRHLLSSVEASRAALTPVPMIMKNCTYVPVSAEEMEMLNRLACEAPSCTSLPAFESLEAHPTYQTLLQRIDDALQSQRAATVVTAGGESTAFFPRLGCPGGAPWDWSVESEEGRRLLRQRCPLPANGAPTPLERDLYTQRLWYHMNQLNRCHSARDVVRMLCGSRRVREALHRCSEAINDASVPSPSGTRADDKAQTNVSLPSSTPKASGLTICLQPWLYLPTVGCEVTAYLERGGRRIRGVVQRYGQVRLMTSATLLASAFAVVGDAADPDALLARYAVLESATDAAAEEDLTRELRVFQRSFASAVDDVALHLQTHSNSVGGDGAAWCVHLAVVLTPNSVPTAGRLPSVALLSASPYQRALEECSMYSSLAPPSRGADTTASTETRPTNVDVAWNTQRHPYIPLFSRDLLEKLRAGPVGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RS96</accession>
    <name>A0A088RS96_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_210180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698806.1">
        <property type="nucleotide sequence ID" value="XM_010700504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RS96"/>
    <dbReference type="GeneID" id="22574840"/>
    <dbReference type="KEGG" id="lpan:LPMP_210180"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210006500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_210180"/>
    <dbReference type="eggNOG" id="ENOG502QTBB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="245887at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="569" mass="65618" checksum="D3C863C919F5EE92" modified="2014-11-26" version="1">MEALEILRSIAPISSTEEILEMVKSAKNAREVRMVLERIVYTHHLCFDLLNGHGYRVAVLQTLTAVAPHASCMHEWFDCVARFRRLGFVLTRTYAAEGFTTIRQWLSREFLHRGRSPSLVTEGTTHIKELMQWCLEDRLVFDHVLYTRIVFLLTMVVSYLDRQNLYRASFPEDFVKRDGIVVEWVVTNERCVDFDECVLQCDALMEELLEQMRQDIPSRPPFSFMYRLADYYFATDNVEKMIAVMEDAESYGVSVAESTTAKLMQMACAFNSPQVPELLLRWRVLPPQCVLATPDVSRLLFFYSRAGGGLPCPHCGEPYNHRNVSVYCWLQTPPHQRQCPALRKARVQKGELEESQELPQNADWSTQAFRLFELSRARAIEWTAAEWRGFLLCCIFSPRAMEAKALMDQHLDVTAMDDFLRATYVRLLRHHAPAEAWPTLKKWKELQCNMSPIALQEALMATAMVPDAATRLEHMKAVWQLLLEKDSYVMPLTRRFYQRRMAELTRGYASPVGGDGKASQDDLATQQEEAQLMRTVVEMQPRRVSLLDVKDSAADFVVGTRRKNAYRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSA0</accession>
    <name>A0A088RSA0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_241270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699467.1">
        <property type="nucleotide sequence ID" value="XM_010701165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSA0"/>
    <dbReference type="GeneID" id="22575536"/>
    <dbReference type="KEGG" id="lpan:LPMP_241270"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240022100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_241270"/>
    <dbReference type="eggNOG" id="ENOG502S6MJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271119at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055308">
        <property type="entry name" value="TEX47-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34035">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34035:SF1">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24787">
        <property type="entry name" value="TEX47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="254" mass="28557" checksum="79948039594BB6A6" modified="2014-11-26" version="1">MPPRKVDTQVSAVEKISERQSVLDVVLAKIDAKQYDTAYPFQLRVLLCGKKKRSSFDDAWERLAAEVKVQCDKANPFSENSQSSQLGSLIMDYGEYFMQVVEGSERYVFRFAEEMKSVAHVETSSVRILFLDDDVPNTICSGITLIDKVPPSSLTVNLADKSIDEVAQGVTHDLSSILELASQASSQIGRRKSVFTENAKVNCPKLFPKVEMLEAYIKSDSFFTLDEFVDTFCKPAHLVRDEEINHPVTDPLKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSC9</accession>
    <name>A0A088RSC9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="5">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_210430</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="5"/>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698831.1">
        <property type="nucleotide sequence ID" value="XM_010700529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSC9"/>
    <dbReference type="GeneID" id="22574865"/>
    <dbReference type="KEGG" id="lpan:LPMP_210430"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210008900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_210430"/>
    <dbReference type="eggNOG" id="KOG1864">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27652at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF733">
        <property type="entry name" value="RE52890P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="7">
        <location>
            <begin position="284"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="613"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="613"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN98124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="740" mass="81004" checksum="2874952C55FAB5E9" modified="2014-11-26" version="1">MGNEASKSRGTALPSDKPCQSPQLEATVNSGDATAPTAKASSDNASKAINVASPLSPVGALAQAVPPSASSNPAAAPTCLIARSAETSPLKSTSGAIDTFGSSVPCYVDAKSMVYTLPCFVAENCLNSTTSGGAGSRSQPIAMRTAASQPMLITSFGSDLHLGAPSSPLSPSRRHFPGANGSNLIAIPTYNPNTPTAVEDLSSSSPVLKSYRQHSFSHSKRDSCMDNSPTTPCMAAHSLSSFNFRTADALGTMSMANSFSSESRSSSSSKAIHTKFLEITGHPLGLENYGSTCYCNSVIQLIYHCTPLRLRLLELHRVYLTKKGKSGFEEDTVLFQLCNLIAVMHKSNNRTKGKYPREKIAPKDLLNCVRAKNKVFDNDMQQDAHEFTMFLLNDIWDTEQRIMADPANVNLFLQYEASMKKKGLSSFSWKHSKDKSISSHSQKGSKLYKTSLAAATNSNAATDGDKMVGIQKPFSGELTPLQVILQGQFGSLTACLECENVTARDEVFMDLSLETEQGSSLLRCLDHFGDPEYFWGNNKLRCEECKMAVRAAKTIHVQRLPQYALLIHLKRFQYDVKRQIFTKKADHVALPMQMDVAEYLTDSEVIEQTLRNEQARRQKNGSDDAGNNDNSRRKEDGTTADSSPDTFKPASEEVRRKLRGIARHKARFELTGFVAHIGEGPNSGHYFTCVRYGPQLWRRFDDETVSTMVERDVKQYFGVPSDAVGVVTTTAYILLYERVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSD4</accession>
    <name>A0A088RSD4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor 100 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_250180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699590.1">
        <property type="nucleotide sequence ID" value="XM_010701288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSD4"/>
    <dbReference type="GeneID" id="22575666"/>
    <dbReference type="KEGG" id="lpan:LPMP_250180"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250006900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_250180"/>
    <dbReference type="eggNOG" id="KOG1135">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="64353at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000102">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027075">
        <property type="entry name" value="CPSF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025069">
        <property type="entry name" value="Cpsf2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922:SF1">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13299">
        <property type="entry name" value="CPSF100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Beta-Casp" evidence="6">
        <location>
            <begin position="256"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="419"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN98883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="830" mass="90472" checksum="AFC7C8E8AAA2AD5E" modified="2014-11-26" version="1">MLRASAGSIRLTSVYECTTPNAPYAYLVEIDGVRILFDCGWNEEFDTSFLAKLKPHLATVHAVILSSPHITACGALPFVLTHIAPGTFVAAAGATSKIGVHSVLHSFLYQYPNSHTFTLADGEGFTMTVDSIYHSFRSLREPYGGKVTVKNEDVEVNCFAVFAGRMLGGYSWTIKYQIDELFYCPDFSVKPSYALKSFDVPTTANIVLVSSFPFHMTVSNRTTKYEEQLKSLFKELQHTLRGGSDVLVPVNVAGRGLEVLNILVHLLAEQGGDKYKVVLVAAQAQELLDKAGTMTEALQDYLILDDKRLFANVLTCRSAEEVLPIQGPKICVADGVSLDFGPSAELLEYFVKGNRDGADHLIVLTEPPLPGTNATVVTAAGDGERLHFQITRRSRLSGEELEEYYIDLEHDVEQRRRELEAQSTFQVVPDDEEDAANTKGDADDDDDDDGEWVAAAATSHGGAAEKPSTISGTTAATTAGAGDAAAAPAKTKAAATTPGLVLPPSLHYHSKHLSFPVLETASTLSAAALKRIDVAYGLPVSEEEQVVLQKRAPARQHSDAGPEALQVENDAQRLANIPSKVSRVAVEVTRRCRVVLSDLSGYPDALTMKSILKTKWTFAKKMVGLRGNAEDGRAFQHFCRADKSMKCGSTVFSVTSSGVPLELATHVYSYAVQLESSLARSLSRGLRRVRETKSKSTWEVGWVNGELSGVRAEADLVEPEVQRCRSDRASYFLTAVTADKSQACAAQREQQGLQSGSFFVGDMDLRRLRETSRQESGLYSEFHKKAPLLVFDEGVCVRKGADGTVTISSIATPALFDLRRTVYRQYSQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSD5</accession>
    <name>A0A088RSD5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pyruvate dehydrogenase E1 component subunit beta</fullName>
            <ecNumber evidence="10">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_251790</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="10"/>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699749.1">
        <property type="nucleotide sequence ID" value="XM_010701447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSD5"/>
    <dbReference type="SMR" id="A0A088RSD5"/>
    <dbReference type="GeneID" id="22575827"/>
    <dbReference type="KEGG" id="lpan:LPMP_251790"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000034600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_251790"/>
    <dbReference type="eggNOG" id="KOG0524">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10266385at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000006">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027110">
        <property type="entry name" value="PDHB_mito-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006667">
        <property type="entry name" value="PRK09212.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008854">
        <property type="entry name" value="PRK11892.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624">
        <property type="entry name" value="DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624:SF96">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 10 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="9 10 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="11">
        <location>
            <begin position="25"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN99042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="350" mass="37913" checksum="DA492D438A526310" modified="2014-11-26" version="1">MRRFASRAVFSAPAAMATRCATTSMTVRDAIQSALDEELARDDKVFVIGEEVAQYQGAYKVTKGLSDKYGKDRIIDMPITEHGFTGMAVGAALGGMRPVCEFMTFNFAMQAIDQIVNSAAKSLYMSGGQMKCPIVFRGPNGASAGVGAQHSQCFGPWYASVPGLKVIAPYNCEDARGMIKAAIRDDNAVVVLEHELLYGESFPVTDVAADKNFVIPFGKAKIEREGKDITLIGFSRGVELCLKTAEKLAAEGVQAEVINLRSLRPLDRETIFKSIKKTHRAVTVDESFPVCNIGAEICACVMESDTFDYLDAPIERVSCADCPTPYSKEIEMASQPQVADVMAAAKRVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSM9</accession>
    <name>A0A088RSM9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA-binding protein, putative, UPB2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_250500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699622.1">
        <property type="nucleotide sequence ID" value="XM_010701320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSM9"/>
    <dbReference type="GeneID" id="22575698"/>
    <dbReference type="KEGG" id="lpan:LPMP_250500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250009500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_250500"/>
    <dbReference type="eggNOG" id="KOG0145">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266020at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000658">
        <property type="entry name" value="RNA-binding protein, putative, UPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002343">
        <property type="entry name" value="Hud_Sxl_RNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050886">
        <property type="entry name" value="RNA-binding_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48024">
        <property type="entry name" value="GEO13361P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48024:SF56">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00961">
        <property type="entry name" value="HUDSXLRNA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="28"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN98915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="168" mass="18999" checksum="2D8A2C467F73F91D" modified="2014-11-26" version="1">MSQQMTPPQQQQMPSQQQVYNPEPEALRNLMVNYIPTTVDEMQLRQLFERYGPIETVKIVCDRETRQSRGYGFVKYCSAASAQQAVNELNGFNILNKRLKVALAASGNQRQRPYNAAPPGANPAANMGYYGGNFAPTGYPQANPYAQQHMMAMQQQYMMQQSGQQPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RT78</accession>
    <name>A0A088RT78_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_262390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700059.1">
        <property type="nucleotide sequence ID" value="XM_010701757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RT78"/>
    <dbReference type="GeneID" id="22576142"/>
    <dbReference type="KEGG" id="lpan:LPMP_262390"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260028700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_262390"/>
    <dbReference type="eggNOG" id="ENOG502RHBZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00121">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="474"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="642" mass="71530" checksum="2285BAC309E6434C" modified="2014-11-26" version="1">MESVEAVELFSENSARYRYRVPVSVIRELQYEGSRYSAEFNVGGWFWRFHIQERAAEGQRFLALHLQSCTPGIVSVHFKLTAVCMRDPLQSRSKTFNCTFKKARSAWGLHQFIEIEQLLHPENGFVYTVQETGTRCIDFEATLQVDSGGGSGRAPPVRSATRSVTPTRSVMGPGILGINGGRISPHRGHSVRSVGGRGSSASVGLNSRMFYSPGRVGAGALVPMERSVDQLGAGVGVGLPGGFYNDPNGGPMVTLDSASTIKGGGRGHGSTTVRAPLTYPFEHLEVLCDMSFDVQGVRVKAHRCVIGARMQPLLPEQMLPLQAGCIVAIAVPLDVFTTFLRYVYTEEYPESGVLPPESLLDLYLLAAACEFYDLSAVCIRYVRPLLTPENILPIVLTRYNAADEVLTSLYLHVLLDNYDVLIQDRQFEEIPGHLFRRLSLILYRKETVPNAPIPSMKNTLGKQLAWLAESGEYSDYEWVVGPHQYAVHAHRYILACRSVLFSQAMNPRSPGPLPSFATNEFDFSLRSWQKLLLGMYRRHLDTERDFSAEDIAAIFKMQQVLVMDGQLKREADEALTHTNALRLLIYAVKHQIPELHERAVNCLVSNFSAMVRNDPQAWELISELPQAAVVSLFRTVTEHQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RT86</accession>
    <name>A0A088RT86_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA polymerase sigma-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_260490</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699870.1">
        <property type="nucleotide sequence ID" value="XM_010701568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RT86"/>
    <dbReference type="GeneID" id="22575952"/>
    <dbReference type="KEGG" id="lpan:LPMP_260490"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260009700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_260490"/>
    <dbReference type="eggNOG" id="KOG1906">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273917at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043634">
        <property type="term" value="P:polyadenylation-dependent ncRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045862">
        <property type="entry name" value="Trf4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092:SF15">
        <property type="entry name" value="INACTIVE NON-CANONICAL POLY(A) RNA POLYMERASE PROTEIN TRF4-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092">
        <property type="entry name" value="POLY(A) RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="5">
        <location>
            <begin position="165"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="4">
        <location>
            <begin position="385"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN99163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="519" mass="57570" checksum="6A8B5E73F621E3DC" modified="2014-11-26" version="1">MPAALKKPHASARGSRSATPHGRHARTRHHEKIEKESANTTKKPSPHTTSRGIERVTGGHHSQLAHHQQSEEEHSSRTHSTPLSQARSHHGRRRRRDSDCRVDDEDGDCSSLPDARHPRMETSPVLVAVASNPFHVLASLPRFSSEVFKSLLPPSSVATCILALDAKLIELLYCLSPTSEERQTKLRVIDDVRTTIQQSGMDIEIYGSLYTGLTIPASDVDCVLMRSGNEQIASAMREDLLCAMSSIASAATGLASQRQVRGSLSVALRTVADRMRRSQKFTHITWIGHARVPIVKCRHRRDDVKVDMSFEKGGCVSSNYLCNLFCKPGNEMARPLIVLVKALVNNCGLDDPSIGGLGSFPISLLVLWYLQHCVRSRFSVELQRSIGVLLTGFLKYYGTEFDFRHLGIDYVQQKTFTKPPADDLYIVNPIHPATNCARAATLFATRVVPLFQQASAAFLGLLDAKAPPTKMESLLLHYFAKAALNVSSWREVSRRAAREPHLQQNMWDAETNMYVGGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RT96</accession>
    <name>A0A088RT96_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DPH-type MB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_262600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700079.1">
        <property type="nucleotide sequence ID" value="XM_010701777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RT96"/>
    <dbReference type="GeneID" id="22576163"/>
    <dbReference type="KEGG" id="lpan:LPMP_262600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260030800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_262600"/>
    <dbReference type="eggNOG" id="KOG2923">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="66964at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.660.10:FF:000008">
        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.660.10">
        <property type="entry name" value="DPH Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007872">
        <property type="entry name" value="DPH_MB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036671">
        <property type="entry name" value="DPH_MB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05207">
        <property type="entry name" value="Zn_ribbon_CSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144217">
        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51074">
        <property type="entry name" value="DPH_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DPH-type MB" evidence="3">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN99372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="80" mass="8912" checksum="7B0E5FE6AE9A5989" modified="2014-11-26" version="1">MEEFHYEEVQLSEMTLEDGVLRFPCPCGDLFELLLEDFFAGNDVAQCPTCSLTIKVLFTNEEKSSFLAQNKVDAVCAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTA7</accession>
    <name>A0A088RTA7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_230380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699196.1">
        <property type="nucleotide sequence ID" value="XM_010700894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTA7"/>
    <dbReference type="GeneID" id="22575242"/>
    <dbReference type="KEGG" id="lpan:LPMP_230380"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230009100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_230380"/>
    <dbReference type="eggNOG" id="ENOG502S18B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277978at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="301" mass="34673" checksum="33B51BB8CCEF6DEA" modified="2014-11-26" version="1">MRSKGVAATSNGDVTAEEARFGKKSHRGRRRAGRRASGADNNSEGCENTETPVEEYHYKHPKQRVLTIALFMWERVATFCIPSQVAELERVSRDVARHLTDSNTGTRLMQRYWNAQWSRMVWKEEELTDEKRYLTPTMLKHSEGKQSWKKLFVQEYPIYLQRVHQGSGVCNNAVNEAKVLFHREVLNTVKTAAELKRLELTEEEARVKEQRKRGVDVEFEEAPNTAPSPSSLDGPHGAPAAKKEREKREKGRPRAVEKAPHESYTRSDYKADYRTGDRRGKHKKGGTGRWSNFDNFGDYDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTV9</accession>
    <name>A0A088RTV9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peroxisomal membrane protein 4, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_262370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700057.1">
        <property type="nucleotide sequence ID" value="XM_010701755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTV9"/>
    <dbReference type="GeneID" id="22576140"/>
    <dbReference type="KEGG" id="lpan:LPMP_262370"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260028500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_262370"/>
    <dbReference type="eggNOG" id="ENOG502RXMH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="39659at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019531">
        <property type="entry name" value="Pmp4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15460">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15460:SF3">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="226" mass="24919" checksum="2AEF65CABBC8FC8C" modified="2014-11-26" version="1">MSIVVPQVAPKAHTVPTFSGPHGAVVERINRMIASGDFDVFFTALKGFRNGLVYGTRVRAPHALVLNLVWSKSPYSSMPAKILKVTKTHALGLGYSSATFAVIRGILRSLQGTTHAWHNALAGFVVGCLFWGDPSNGVHVQMMMYMLARIVCALYHLLTSTCVMSIPPVAYRLYMGCLWSLAIMFLMYSPDKLQSSMAQSLEYIFKDSGKFSSWYDLVVVNSVDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTW3</accession>
    <name>A0A088RTW3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_262420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700062.1">
        <property type="nucleotide sequence ID" value="XM_010701760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTW3"/>
    <dbReference type="GeneID" id="22576145"/>
    <dbReference type="KEGG" id="lpan:LPMP_262420"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260029000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_262420"/>
    <dbReference type="eggNOG" id="ENOG502S2HR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272601at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="168"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="221" mass="24401" checksum="C8C8DEB4E7EF7A1B" modified="2014-11-26" version="1">MPLDLVGRLHRTVYITACPEGSQEDLLHMLLKRCGAIEAWDAADGRLIVVFQSMNSVSNALTFHGLSFVDLTRKICVWKATDAPPAEAAQQLAIEGSSLTTEVDLEEATSSEAEDARRTQRKIRRAALQQILNSTATDAVDTSSPEGRRAKMMELCYRQLKALCVLSAAAVKDAKAELEEKKENLARLQDLIRTQEAVAKRRREGAVEVGEEEPAKARLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RU01</accession>
    <name>A0A088RU01_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_270150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700102.1">
        <property type="nucleotide sequence ID" value="XM_010701800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RU01"/>
    <dbReference type="GeneID" id="22576191"/>
    <dbReference type="KEGG" id="lpan:LPMP_270150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270007000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_270150"/>
    <dbReference type="eggNOG" id="ENOG502S4JB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000048">
        <property type="entry name" value="ZFP family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032297">
        <property type="entry name" value="Torus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16131">
        <property type="entry name" value="Torus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="115"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN99395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="183" mass="19357" checksum="6594DFBFB28DF5B6" modified="2014-11-26" version="1">MPLHASGVVNGVIPGVVPPHDRTQEVCKYFVNGGCLRGANCPYLHELPDERHLDVNGLGFILNPNVHNAQKTVASPQTPVTAITPSQPLKGTGSSLTMMLSSQNATQSRVFGPTKVAKNQPPSMSGSSSASPQAVPMGKLPAPPKYNPPEPYLELNLPPALAFPLKVPTKDTTATLAHLMLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RU17</accession>
    <name>A0A088RU17_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methylmalonyl-CoA mutase</fullName>
            <ecNumber evidence="3">5.4.99.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_270290</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methylmalonyl-CoA mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.2" evidence="3"/>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700117.1">
        <property type="nucleotide sequence ID" value="XM_010701815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RU17"/>
    <dbReference type="GeneID" id="22576205"/>
    <dbReference type="KEGG" id="lpan:LPMP_270290"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270008400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_270290"/>
    <dbReference type="eggNOG" id="ENOG502QQ7X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="198977at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019678">
        <property type="term" value="P:propionate metabolic process, methylmalonyl pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02071">
        <property type="entry name" value="MM_CoA_mut_B12_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03679">
        <property type="entry name" value="MM_CoA_mutase_alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.280:FF:000002">
        <property type="entry name" value="Methylmalonyl-CoA mutase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.240:FF:000001">
        <property type="entry name" value="Probable methylmalonyl-coa mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.280">
        <property type="entry name" value="Cobalamin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.240">
        <property type="entry name" value="Methylmalonyl-CoA mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006159">
        <property type="entry name" value="Acid_CoA_mut_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006098">
        <property type="entry name" value="MMCoA_mutase_a_cat"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00640">
        <property type="entry name" value="acid_CoA_mut_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00641">
        <property type="entry name" value="acid_CoA_mut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006944">
        <property type="entry name" value="PRK09426.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48101:SF4">
        <property type="entry name" value="METHYLMALONYL-COA MUTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48101">
        <property type="entry name" value="METHYLMALONYL-COA MUTASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="Cobalamin (vitamin B12)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="Cobalamin (vitamin B12)-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="7" id="KW-0170">Cobalt</keyword>
    <keyword evidence="6 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="8">
        <location>
            <begin position="593"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN99410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="723" mass="79368" checksum="733927BA50648A17" modified="2014-11-26" version="1">MMRRGSILLSAAYPPEWIAAAKKELKNRDPATLTVHSTNGFDIKPIYLRDDVKSHPAMPGFFPYTRGVHSTMYTGRPWTIRQYAGFSTAEESNNFYKAALKNGQQGLSVAFDLATHRGYDSDHSRVAGDVGMAGVAVDSVEDMKLLFKDIPLEKVSVSMTMNGAVIPVLAFFAVAAEESGVSQEKLRGTIQNDILKEFMVRNTYIFPPTPSMRILGDIMAYLSKRQPMFNSISISGYHIQEAGGNGALELAFTIADGLEYIRCAQQRGLAVDDVAPRFSFFFGIGMDFYCEIAKLRAARTLWATYVKKMFNPKNSKSLLLRTHSQTSGWSLTEQDMENNIIRTTIEAMAAVMGGVQSLHTNAFDEAVALPSKQSSRTARNTQIIIQEETHICSVVDPWGGSYMMEALTQEMVKRASAIIDDVEAKGGMTKCIEEGFPKLMVEESAARRQAAIDSGAETIVGVNKYINLDNKVPETLRIDNKKVRAGQIAVLEKIKATRNNAKVQEMLKKVTEACKDEKINILEVAIEAARVRATLGEITSAMEEVYGRYVAKSQVVQGVYSSSYVKGCSKEDQNHIAAIKARIDAFAVKEGRRPRIMVAKIGQDGHDRGAKVVATGLADMGYDVDIGPLFQTPEEVARHAVENDVHICGASSLAAGHRTLIPQLIQELKQLGADDIIVTAGGVIPPEDYQDLYDAGVKLIFGPGTPIPKCAEQMIEVLEARQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUN4</accession>
    <name>A0A088RUN4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_280690</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700410.1">
        <property type="nucleotide sequence ID" value="XM_010702108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUN4"/>
    <dbReference type="GeneID" id="22576514"/>
    <dbReference type="KEGG" id="lpan:LPMP_280690"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280012400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_280690"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10057496at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201:SF15">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="53"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="154"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN99703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="233" mass="25742" checksum="F9B0282014838C40" modified="2014-11-26" version="1">MEPYYEPDSEFREPLTDVDAFLDSARYNETGDLDLLKAYLEKNPSEVDARDEQGRTAVHMAAANGHMAILEMLFQFDPQPNVPNDEGNTALHFAALNNRVAAAEALLAHGWRPAEQNIMGKTALQLIYEKQYNEMEALLMSRDETLDTYVPPIQASVSLDLPTKEGDEEENDERDEEPREEAKAAPERKVPRAPIAPAKKIAPAASKVPRPLVPVDATTAVQMLGSASVDAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUS5</accession>
    <name>A0A088RUS5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_251560</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699726.1">
        <property type="nucleotide sequence ID" value="XM_010701424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUS5"/>
    <dbReference type="GeneID" id="22575804"/>
    <dbReference type="KEGG" id="lpan:LPMP_251560"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250012000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_251560"/>
    <dbReference type="eggNOG" id="KOG1122">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="260824at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009383">
        <property type="term" value="F:rRNA (cytosine-C5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07953">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF30">
        <property type="entry name" value="28S RRNA (CYTOSINE(4447)-C(5))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="7">
        <location>
            <begin position="394"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="566"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="399"/>
            <end position="405"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="511"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN99019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="695" mass="75447" checksum="A6E26AF2AF0D711D" modified="2014-11-26" version="1">MISLDAYARYVYQYSSPSTTEHLRRTVWGPLGLCSGASASTKSISGAQPCWRDASISHEVLYAVPPITTNLRCVGNRIEAQLTDRLEALPLSAPAVTTTTPAAATLASRFAPPSRLVSIGLPYCLCVKPQAGHLTPWPPIHTSSISSSMTGTSDSETSRKQPSRRPLVVVVDAGAAEAVLRRSDLYAPGIVTAIRPFHAGERAVVAFYVKRVAGTTDGELNENAEAPRYLTCALPTGATLPAAQFEPLSTDFDYQDEHQQVNRLAGRSTFLVCIGSGVMCMEWKCIMSRSAHGTALRTEWTPQGQPSRTTLRALLGITKDTEDSHEHSGTPILQPQPQGVEKGGKEAEDVFFLQNYSSMVPVALLVDHLSPVSLCRAWTHSNNAAQGHSPTFCTLLDACAAPGGKTSLLLSLLRERAEQERTAMAETATPPPLHIEPFQVVCCERSRPRQEQLMSLLHRHFAADVPYVTRVLKSHCVDTNKFLKRKLTEAAGSSSGGIASHTDTFDAVLLDPPCTGMGLRPKLMPHMQSAASIQRSADYQRKLFDSCIRHIRGSPTSPGVLVYSTCTTTLEENEANVLHFLRTYPSVRLARAKTAAHRALCDLSAVRSYGSQQDADECHGPTSTCFCLLRDEIMDVQMAKERVAAAEGPPSSSPATDPLLLLRFMPRPLDAYDDTSEDGVGFFVAVFLYCGYTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RV05</accession>
    <name>A0A088RV05_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cullin 2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_282250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700565.1">
        <property type="nucleotide sequence ID" value="XM_010702263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RV05"/>
    <dbReference type="GeneID" id="22576670"/>
    <dbReference type="KEGG" id="lpan:LPMP_282250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280028800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_282250"/>
    <dbReference type="eggNOG" id="KOG2166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cullin family profile" evidence="4">
        <location>
            <begin position="404"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN99858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="717" mass="80107" checksum="1DAA98146385C866" modified="2014-11-26" version="1">MCNTVMDAYLLVYHLISHPCSNTPLVKVNGKEIWEGQQIMAVYSLQGTILEKHLLSNVMPAFSQVSSGSTIQTYVRSWRSFLVAVVNIKTVFSSLADKWSLLSLEDNPLDRTEDIALRKWSSVVLTPRMVSQLRKDLRALLADERAGYGSPDLSFAVEIKDELSMLPDSNYYRSVVEADYIRDMCDYCRLKVRGVAESDLFAYAKLCLGLIEEEVRRAEKFLISKDHAVDRLVETLVDDRISVFECGKFSEWLSSLGQPETDEKLQTVFHLLWWSKCKGAPLMEGMFKESVAQHTSTALSGAVCAAGEGTDAYAAVIECFISIIRKYRDVVMSVFDYNGCMLEAMDDGLRCGFTTLRSFSYKKLSDRLAAFFNAILGNAGSTKLCLEDVVSVYYFLPDAENSAKDAFLVSYQKHLAKRLLLHHYDEEREQRSMEQLVQIKQSPILFCCRSMLKATSTQNIYVGASSVNGVKVNPALLSRGTWPSLPHTLARSGISDSVLRQIEGAQRICSERRHGQKIEYSAPYSSAVIRMLRPAGSTAAGDSVQLKVSFLQMCIIDHFNTKSQWTVKELCELLQVSEVECAFALDPLISATVLKLSGAMGPSSVVSLGTCDSLIGDMINVMPLEFHSFTHRVAVKSQEQRILQGVAKANPQRMESQVVHTLKQSGSKTAEELMTFLTAAKDPLTVSRGELKRVLEKLIERGLLVRDDSQRKFVYSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RV32</accession>
    <name>A0A088RV32_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein RFT1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_282550</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Intramembrane glycolipid transporter that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. RFT1 could mediate the translocation of the cytosolically oriented intermediate DolPP-GlcNAc2Man5, produced by ALG11, into the ER lumen where dolichol-linked oligosaccharides assembly continues. However, the intramembrane lipid transporter activity could not be confirmed in vitro.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Endoplasmic reticulum membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the RFT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700595.1">
        <property type="nucleotide sequence ID" value="XM_010702293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RV32"/>
    <dbReference type="GeneID" id="22576700"/>
    <dbReference type="KEGG" id="lpan:LPMP_282550"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280032000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_282550"/>
    <dbReference type="eggNOG" id="KOG2864">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9979195at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034203">
        <property type="term" value="P:glycolipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007594">
        <property type="entry name" value="RFT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13117">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MULTISPAN TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN RFT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rft-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="156"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="214"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="226"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="285"/>
            <end position="308"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="465"/>
            <end position="485"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="505"/>
            <end position="529"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="541"/>
            <end position="560"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="572"/>
            <end position="593"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="661"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN99888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="729" mass="78255" checksum="1415DB4B1D13E3ED" modified="2014-11-26" version="1">MTPSIPSSFKGQLLLALMLSVGLKLVTFSLSTLLTRLLLPYQNGVYFTFNVYNDAVLFIAREATRSVASRLPIIESSAEAEDNAKQDGNIDAAQEVGPAGQGGAENAPSAPSARTPASLVRVANIRGVVSIALCSVPLAIVMAATVEALGACLGPASFLPSLMRYARASQRDFPTAKSVSDLDSAMALTGLPSVVLPYVPEMTVVLCTIIMAAMEPCVVLVQSLSLFRVVVLAECATLVARLCTIIGIAYACQRDIAGGRTSDDEVGNGLRTLWETRMAMAFGQLAYAITHVIYYTLVVSGLPVARWLGSSPEMEQVRAAALLAHARELSQSRQGAVASGSAASAKAAPPSVLPTPSQLVRWSSFVFPFCFYSIGDSVVACRRHCALLSTFLRESLLRLVLSEGESLVLTSLGSETARGYYHLIYNLGSLVVRLLFRVWENACFVKWSLEASLGHRHTAVHLLKLMLRLAFYVGFSFTLLGPPLAQKFLTTMYTSRWATPQVSTALQLYFYALPLMAWNGLLEAFLRAVASPAVLQRLQRWMVGETVLYIAACYVTLTAFGKTDMQGESVSVLVLLNIFNTLWRCCVSIYLLVSSPTVVVGAATAVSTDARAEDVGGPAAPAAPSLTPSSPLVRLLDFLSLFPKRIVGSILGLFVCSRALRANSVVAIVAVGLMYAAVILAGDGEVRRLLVTPVWSRVRLLLLRHRHDSHTGPAAVSLQSVESAKSKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWF1</accession>
    <name>A0A088RWF1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_292890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700893.1">
        <property type="nucleotide sequence ID" value="XM_010702591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWF1"/>
    <dbReference type="GeneID" id="22577052"/>
    <dbReference type="KEGG" id="lpan:LPMP_292890"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_030014100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_292890"/>
    <dbReference type="eggNOG" id="ENOG502SESF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="261218at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050836">
        <property type="entry name" value="SDS22/Internalin_LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652:SF3">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO00236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="692" mass="75069" checksum="67840534EE1291EF" modified="2014-11-26" version="1">MNHTVRTVQDVHERLLSTEVYRMSCNRGYRILETLKDDPLALVLCFVSGSAFFTMAAVSPNVRLYNELALDAVGNTWRTVDFSGKRIFHTVEDGRVPHDLNLVLDFSSWWLRKSALPVKAQGASALFAVLGASTDVASMVEVVELGLKEYYILNPYALEPERVDARVTSEIDAALRAVLASPAHTLRSLHVGGCSTTTVQLIGTLPALARLSIHGMQQRELSLHTLACARHLESLSFVGAQVEQLTCFALCRALVDVSFVHCRDLRSLAPLAGASQLRFISVVSSDVESLGGLADCPNLEEVRFTECERLTSLAPLAGAPRLQTIAATHCAVRNIDGLCTCPHLESVDFSWCAQLLSLTSLSGSPCLRSINAAWSGVQLIQGLNSCACLEKVNFTELKQLRSLTPLAGALQLRVISAMLTGTETLDGLKRCLHLESVNLTDSRRLTSLAPLAGAPRLRTLNVRGCPLNCIDGLGTCPELENVSFRCAKELMSLVPLAGASQLRVVDASWTGVRSVDGLERCLQLECVDFTGCHELASLAPLSGLSKLKVIKASESAVDSVDGLNCCHQLEFLHLSRCARLTSLAPLAGAPRLQSIIACWSGLLSLDGLNRCPALMYMDVSHCRQLRSLAPLSGAPRLRKIEANHSAVRHLDDVHISAKVHLNYVWVKLSRHRKKSAKRAHGDGEMTGGESNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXB6</accession>
    <name>A0A088RXB6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_282770</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700616.1">
        <property type="nucleotide sequence ID" value="XM_010702314.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22576722"/>
    <dbReference type="KEGG" id="lpan:LPMP_282770"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280034200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_282770"/>
    <dbReference type="eggNOG" id="ENOG502S0FW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="252964at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051295">
        <property type="term" value="P:establishment of meiotic spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007051">
        <property type="term" value="P:spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051185">
        <property type="entry name" value="ASPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22706">
        <property type="entry name" value="ASSEMBLY FACTOR FOR SPINDLE MICROTUBULES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22706:SF1">
        <property type="entry name" value="ASSEMBLY FACTOR FOR SPINDLE MICROTUBULES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="45"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="127"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="337"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1509"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="362"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1525"/>
            <end position="1535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN99909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1782" mass="196008" checksum="D82E4CC3C56B8EB8" modified="2014-11-26" version="1">MFTETQPKEVVLQGARKASPNFAKDAGIVRAAATMVHKVGVSEPMKAQRGSSATCGGGALPPIHTKTASTSETAVVPRPRKQRPLSDFQELHQRLVADGQAFPVMLPAVGDLPDQRPSAALGIASTLRSGDEVPSSFSPAPRRPPSTSRPAARHRRMHASLPRQARQPSTSPNGLRATSTRASGVGWMEGRRHSGQASRRTGLKSLKQQVEGDEAAADQLMQAENTGGALMLLSHTLKSVLDYRVSLNSGSSRINVVGSTVSARAAPAAPPPGEPGAAWAAKTAQRLAEVYTVIANNAGVRCSTAAEPIQIQEAYFQAAMRYVVKKSTEDLFSEWTAGSAAATSKGQSPHPPQPQSHRRLPARSAAPPSAREPPSCFSSTCPGKSKDGAQQQNQQPAVVRRLLRCAVRTNAAVCLGDSATLGGQARIIYELLKALAESDGVWSMTVLYNLAVAFLRVGGYDDAAEAIARFMELSWHYLEWAQHMHETDDDGGVTSVTAAVHTQAALQLICGHHFIAAMAAWCEPHGLTELYHCELASACAERYLDHADKAQRECQHRLAAAQARAAAAAAGASAPEESTRTATDGPPTLLLLPYMTQDLVFSCPSSTAVAAMGGVASTTVTVHLLVEALAASSSLSASLPAEVRAYVREVQKGDALRYWARAALRAGASPPFLSAAVAASTATPVPPALVVLLNHREEGEDVWTRESWMTSQVRKVAADDASSSLRRLLSAATTTGVSRASVIALTSQRVGAVPGMQPDASASLIAPAAPTPHYELGASSGKPAPLFVTTLPNSAYDRYRKLRDGVITQLGNAEQMVQQGAGVEDAVELLAVEGDAKVAARTEGARSRSMAVSKSLPADAAAVHSRERHMTTLFVGASGTATSPAASLPREVRGGDIAAACGFLGEEMPEYHDASSVTTTAALDLTLLGVPIRPSELLRQLDWETEARYSRLVADPLADLQRVASTCIQVWWRMQLARQVRRRRAADVETCLRRDAAAVRIQSGFRHWKECAPAKRELHRLRAYRERVRCTTILQAFVQQRASVEVWGRACLVWYKTLVKQREMEARRAAAAVTLQSWWRMHMARRQLCDSVTAVIRLQCWWRCALARRELRTRHVHHRLAQEQWRYERLPQIILVQRWWRACRSRWAVRDLLCQRQRSLEGYLRALESSYDAVMRTHLRSVDNVEAAMRCVLAALAGARDRRQLGQLAMRARVRQRAVHSFVLQWRGREEMWQLRRDRAAALALQRRREEVAVATVTLQSWVRSWLPRRCAARERASRAFQHACALKIWDAFRHYRARQALVSGRTQCDMLGVVRRLAEVRNDAATRIQSMWRMHCTQREFFDLLKFMLRDRHEYATAVQRCWRGHYARAVLAPRRAARVREYEARLQDRTVLRCAAVRVQSFYRMYRTRIQLLRLGVLLPPTFMHRITAARRIQTSWRTYTAYRHVLYLRLQRSYAFKLVQSQEALHTYATLIQAAARSYLVRRGQLPRPEPAPNVLVSVKTSTKLPIPRPPSLPRARVAPESGSTPLHSVTSGGHGVETSPTSLALMRAPATVLQTIAMPMVSSCCTTAAVHSSPPDFGDRPSAPSLVTVVSPTLFQTTRAAKSCSNSASLSCLSSTPDKPLYLLQSDSTDGAWSARSARHPASSSGERAAIDSQQVVASSHDTARLSAPTKDSVAETTAYSADPESDVQAMMELPVAQCSIACSSSLCHHTPQEVEAAVRIQASWRGYRVRCTIEFFYEEYYEEVDEEGEEVMEEKSQYTNTLSLSESRERWDMVHHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXC6</accession>
    <name>A0A088RXC6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Gamma-tubulin complex subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_282920</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700631.1">
        <property type="nucleotide sequence ID" value="XM_010702329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXC6"/>
    <dbReference type="GeneID" id="22576737"/>
    <dbReference type="KEGG" id="lpan:LPMP_282920"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280035800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_282920"/>
    <dbReference type="eggNOG" id="KOG2000">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5860513at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1900:FF:000020">
        <property type="entry name" value="Spindle pole body component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF14">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="6">
        <location>
            <begin position="278"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN99924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="594" mass="67943" checksum="31BA3A02F9532855" modified="2014-11-26" version="1">MWMGVSHTQYFTYDPSADVYRLAPDTCGAVQQQAAEVFQECGVLARHIDVALRQPSATGDSFLQQSLRSALRRQLTQYHYLVSMLRERRSPPLRMGDLVVAYKRVHPKLWAMDCVLRETQHVKGGELASRMQQLVQHGSHRLASLLHDIYIETVSPLLHMTVESITKGDVCDPMHEFYIVPVDGIDDAAENFWVAKYVLSTEMLPRTVPEIVAQDILLVTKNIRFICRCCRAKQWRMDPSLIAEAERATFDTLPVVVHRALIFTNTAVLRLIREEFQLHEVLRLVNAFLLVGYGDFYELLITKLEPVLSKMSSTVPVSVVRDQVKSALAEITPYAKHLDTDRFALLHAELVKDEAKLGWDTFVMTMPVSSPLNNIFDNGAMRVYRRLFRLMFRVKVAEVALKKAWRQNVVLDRLISSVQRTAQETSAWREVAADAHLLGLQLNHFVNNLWSYLVAEVCTVAQDLLLKAVAQCTSMDDIRTAHNTYLAYLTQRSLLHTDCATIRMNVENILTIVREYCGSQALLASLLQRGSGDLSTVKRQYQGLTDDFHREMSSLLTTLEEQHVNFDFLNFLLLRLNFNRFYHDTSDMADNTEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXL7</accession>
    <name>A0A088RXL7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">U3 small nucleolar ribonucleoprotein MPP10, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_290740</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MPP10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700682.1">
        <property type="nucleotide sequence ID" value="XM_010702380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXL7"/>
    <dbReference type="GeneID" id="22576838"/>
    <dbReference type="KEGG" id="lpan:LPMP_290740"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290011600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_290740"/>
    <dbReference type="eggNOG" id="KOG2600">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="445326at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012173">
        <property type="entry name" value="Mpp10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17039">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17039:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04006">
        <property type="entry name" value="Mpp10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="123"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="187"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="636"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="139"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="312"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="640"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO00025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="682" mass="76465" checksum="429C217DA4117E3C" modified="2014-11-26" version="1">MPSNSTSASSPGKAMAGPKLGGQLRSSERVLDRLTSSPMDHLVASRRSGDAVLRESLTALYSLATKLHSPALRFASSTIETRKERHITTEQVWGQLNVLMRPVLRQLGNNVHRARLLYGGSAEGASAKATQQRSRKAKATTDKDDDGDRSADEPDGDVAGKAILSTRTSELDESDLDEEIESLLAKQVERRRLRKEARGGGGGGDDSWRYAFGKENAGEEDGEEDDWDGEGSDHGRLRRRRRQEVEEKVEEEVGMDFKEDVRDGALADQRARDRNLQAMVDAQDDAEPEEDLAALRELYGDDFEDDGRGFLGEEEDEDPDMEEDIELDDPANEAADDAYNERDGAYFGKGDILNDEAGDFEEEHGGYGSCARYGGGEDGDDTGVALQDEAKEMDEELLAALEDPSLSELQKERLREKHMVRKMEEKRLFSTDWSMVGETTASKRPRDALLEVDNLEFEYGMKATPVITEAFTAKLEDRIKQRIQDENYDDVKRKMVLSTEADITHLKYDAALDAQKSKMSLMDLYEKDFLEKQRLADEAAGGPDAARAEPLTEIEKDELRAIQMWQRLAQHLDALSNFHYTPKPVQQDLEARVRAVENQAPAVVIENVGNFATTRENALAPQDLYRGSSHRFADVGVDELTPKERQTLRRSKKEAGKKDKERKEARDKQRADARKQKQQSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXN3</accession>
    <name>A0A088RXN3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_311590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701549.1">
        <property type="nucleotide sequence ID" value="XM_010703247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXN3"/>
    <dbReference type="GeneID" id="22577585"/>
    <dbReference type="KEGG" id="lpan:LPMP_311590"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310022000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_311590"/>
    <dbReference type="eggNOG" id="ENOG502RY6X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="238331at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="282" mass="31355" checksum="30EC6A1BE8039055" modified="2014-11-26" version="1">MSTTAGTLPPVKGTSAKRSLQKRQPADARGNGTSAAADPHCYHKCRCYGHDETLPNYKLLAIPRTNNYYAATGGCPCVPRVAAHPGSWRLKEGQLRSSTYRCGTGCTKKSAAATLGCCNHSGDQYGWRRGPHRVLDKNTAATGKCDTFGNLAFKSTSGVYCGVDGDDLSDVSSASPQKLEDLEALVLEEHQQRMRVEEDVDELAGIQHNGTADFYKKKHNDAARRRLLAQISEVELQELLRDVKNIVDRPLNQTNMDLLRRILHRQEHLQRQREYYASQVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RY22</accession>
    <name>A0A088RY22_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinetoplast-associated protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_312610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701646.1">
        <property type="nucleotide sequence ID" value="XM_010703344.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22577687"/>
    <dbReference type="KEGG" id="lpan:LPMP_312610"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310034000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_312610"/>
    <dbReference type="eggNOG" id="ENOG502SJVX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273923at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056661">
        <property type="entry name" value="DUF7759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38758:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38758">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24945">
        <property type="entry name" value="DUF7759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7759" evidence="2">
        <location>
            <begin position="1210"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="880"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1012"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1122"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="891"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="912"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1012"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1122"/>
            <end position="1139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1318" mass="136167" checksum="C53CEE4AA0E70004" modified="2014-11-26" version="1">MAPRRSRAKRLHLLGVDRRHVAQPSPANRVAVASPTVPPPGATAPAAKPPTCVEPPLAACVKPEATSAEPGATAAAKTPAAAAPDSTPASTLRTVEHTTEAQVLADVKAAPVATSASAVPAGKALTTAASVSAVPSVQSARAAISAHRRRLRAKRHATAALARKAKHHRNISAPQQAISFSKLFQPSAPARTSEMASTAAAGAPATEAAVKPISVVAQPNITQANFTASELTEPTAATEVAPLPAPAPITIPHRATISRIPKKRKFFAELDDSVTVPAAEATPLASSKRHLLTSDAAVAPRGAVEAGTAALPAREAPPLAPPVTPAAVVEEMTEKTSAVADDLPAPAAARRMATHRISKKPARGATGNPTNSSGGLLPAETTLEATLAAAAVTKKAPVFNAATLTMPETSAVPTPPVVGAPLVELPQRSAPSSPPLTAPEMTSAATVASMGRATMSRISKKRKRFFAELDDPPASDATLPIQETLTVPADLSAAVTLDDTGIAATMAVVEPTVPAVEAAAVPPAAAVAVAEAVLAKPTATQGVVRRRSRRRGRLPPRTAVEEALTATEKLPSESTASTLATPIAEATLAAVTESGQGAEVAAPAESAGETVATTEAVPPVEAVAPPAAVRKRGHSKPQSSKVKRLTAAAIRRRELAAYNRIPKRFRPPVAPRRVFPTPATEQEGATALTDASAATFVVEAVEVTETPQPAAVSTAQTELVKAVPEMCTERKTTAAVEAIADPPAAEASQPPPGASTAWGAAAVEPAERLTETTKSTALPTASVEEQRLVGHGRGAPKSRRMRMTPSPKKRFFTALEEVPTANLARVEAAVVVTETTAAAGEVQLAIPQSHAGVAAIHSSLQVAGDDTMVDADLTAVAEETAAPQSALNTGSEAASATAAVEEASTEAPQPMADQQPTATTSAEETPFEAVDAFCIGDAAPASEAPAAHAQPPAPAQRKVIRFTNVRDMLKAIRKAKQAGKRGSAKKRLCGKSSLPHLATTITDVVDEVVSAESSSSAAEATPSAEEVGAEIGAPPPHEVEAMTAVAKTDAPAATEQQTVGEAAPAAEVEVEMNVEATMTTVTPEVTEACSTAPVNKEAVQSPETQPCAEFLMSPAQAAVAAPAEDLPPVASSSPSPARRQAAKQKIKKHAKLAAARLNKHQTYTVSAAIPLATDYTPAETMDAPLVEAVHSAAEPFAPPAEEASAATLVRHAALMLPSGRVVMESFTDDEMVLRRTTLDDSWDVGLRFDWQERTLTISSFPTFEEADKRAAHPFVQRFKSRPRWLLMEVNEASAAHMKRALDSMNRSLTARFVFRHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RY75</accession>
    <name>A0A088RY75_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial carrier protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_320130</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO00901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701701.1">
        <property type="nucleotide sequence ID" value="XM_010703399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RY75"/>
    <dbReference type="GeneID" id="22577754"/>
    <dbReference type="KEGG" id="lpan:LPMP_320130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320006100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_320130"/>
    <dbReference type="eggNOG" id="KOG0768">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276989at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000246">
        <property type="entry name" value="Putative mitochondrial carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="95"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="208"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIO00901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="311" mass="33082" checksum="07AFC95EC2008CDE" modified="2014-11-26" version="1">MESLVAGACAGLFVDLSLYPIDTVKTRIQSKEGFSASGGFKNVYKGLSAMAVGSVPGGAAFFFGYDTAKRMFLSLTASSGAASGIDGAVIAMTPSVMACQAAAALCGESLACCIRVPVEMVKQQMQAGHHTTISSTLRTVTNDMATLGVAPGDAAASVSSQPIRLSGVHHLFRGMPIMLMRELPFSVIQMSLYESLKAKMHASTDHPYASLSLPFCGAFSGGCAAFFTTPLDVLKTRIMLFRRAPGQQKVGIRCVLDELIREPARSGDRFGYAQRFFRGASTRVLWISLGGSIFFGTYEFVKAGLQNLHTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYQ0</accession>
    <name>A0A088RYQ0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_302070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701230.1">
        <property type="nucleotide sequence ID" value="XM_010702928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYQ0"/>
    <dbReference type="GeneID" id="22577260"/>
    <dbReference type="KEGG" id="lpan:LPMP_302070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300025200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_302070"/>
    <dbReference type="eggNOG" id="ENOG502S8WY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272694at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="535" mass="57916" checksum="640CB3E1EAE3FC00" modified="2014-11-26" version="1">MPAMESLRTAVDNAPLLVNFLRLIRNARSPNYKDHEKGPATFHFGGLSMRDTGSYEEAEELWRQSSWSSGALAPNAAAPFRGPLHLVVYLNRSPVEVWTLQDYREPATDHSVPRDFEQLEALNTLVRVLFAHLRCQDIYSVVLQSCITSTAGANNHFPTSPQGQDGSPPHSPLSRNTSRRTRTPQTPANQVSLRLFRSADECPTIPVHARRQYLWSSDDFVRLDVTMNRTWRHHTWIQAGTQAASPVLVVGDRERDAAVHVARERSSPICTGGPGLRHFGSEADGPSQAISLEVMNSLGKSSLPTPYLAPAPALAPSSHPSRSSGMTLSPLMPGARLSPAQGVSEFALPPAELSDLFDGDRSRRSRSSPPMTHSSVFASSHPAGGGGGATHTTAQGAAHQVEDAVWLSNAQHVRRMGMLVYSRKQSPSSSSSPLAGKKARSGFTQQIPQMGSLVPSTSIGALSGIDIDKRFLSDVNLEELGEETTSPRISTSAPSNTATEQLISLLGLCSKVKLQHVQPAPFGELVLFLNLREVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYR9</accession>
    <name>A0A088RYR9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_323970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702078.1">
        <property type="nucleotide sequence ID" value="XM_010703776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYR9"/>
    <dbReference type="GeneID" id="22578138"/>
    <dbReference type="KEGG" id="lpan:LPMP_323970"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320047000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_323970"/>
    <dbReference type="eggNOG" id="ENOG502S2B8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="434393at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003377">
        <property type="entry name" value="Cornichon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03311">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01398">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="188" mass="21433" checksum="C9E1467F540FBE83" modified="2014-11-26" version="1">MSSTKRLTDAFRLQFQWIPVLITDRSHHTSGERKRSVLFAVLHVTFLLVLCGHFVSVMASWVLAFILQAGAMGLCVLHLTILEEYADRMNKSLELEHVINPLIIAEASVRCFACLQCVLSRSWLLLLAGCVEIAYDVYVVQHRSLLIDGTTIWKEVDIFRTDGRLRVAYQLLMIPVCILYLIFSIYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZ97</accession>
    <name>A0A088RZ97_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_323690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702051.1">
        <property type="nucleotide sequence ID" value="XM_010703749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZ97"/>
    <dbReference type="GeneID" id="22578110"/>
    <dbReference type="KEGG" id="lpan:LPMP_323690"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320043800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_323690"/>
    <dbReference type="eggNOG" id="ENOG502SQVG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273462at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37562:SF5">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37562">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="405"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="405"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="180"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="466"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO01251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="634" mass="68412" checksum="D0C142363689B9B1" modified="2014-11-26" version="1">MLIHLTESIKRRTHEDAIDIGIRLDTQKSCRSSLCINMFADFPDTRDSDASIVASYSGATAPTWSWTYSDKNALGCDDTDANLPAPEEADVKALLKLLSTKYDVADPTVTEVPASERSVTPTTPGTAEKTEGYLAGSDSLNLSEDLLRVLRHKGDADTMMEWESPTCLVNAFPISESEYPYDASSPNAQTRSSDSSSGSIGPNPGCATPSNSSCDKQGVMSEPTTPHVGRHTTVSHTFEKIGSGLATENFNVLTPDKHMMLSIPAEYIQTTLGSRNYLHRNHDKLVFSSCLCKMFCSGATCRHGSECDFIHCRPDELSLVPDAALPKDTEGHGTAVVHSFQVHWSTPVASLLEAAYPRLPSGYVVYVKGEGNARGGMSQNATQALPSEMVYATVGGQEALRLPSSSPLRICKHFEREKCARGALCHFIHPVVLMMQIVGEPVLQPETVDLTHCKRDAVPSMRPSGHDTTTFSRPPLQTATDCAPQHLLTPVCYTAAADVPSFTGATPQPLQQQMHGQPTATANQRLLILTTTQPPPGALVRYEGVMYMWGQERKHLVPLQATKASNYLGSPDQTLVTPLGVDYSQSVSGLMGSPLGYQMPVNAMLTQSSSSFASSPAINGILDSNSVLAQGFMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZC9</accession>
    <name>A0A088RZC9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclic nucleotide-binding protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CARP1</name>
        <name evidence="2" type="ORF">LPMP_324100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702091.1">
        <property type="nucleotide sequence ID" value="XM_010703789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZC9"/>
    <dbReference type="GeneID" id="22578151"/>
    <dbReference type="KEGG" id="lpan:LPMP_324100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320048300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_324100"/>
    <dbReference type="eggNOG" id="ENOG502RFB6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="417078at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034236">
        <property type="term" value="F:protein kinase A catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF164">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="236"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="385"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="699" mass="79587" checksum="46388B609ED093FB" modified="2014-11-26" version="1">MEPRKNTSVFLTSLVFYDERGQDTQEERDDSVGFLVPFRVPPMPRSITTHRYASLNLLPRGRSGNSRTLMSWEKQMILARLEKNAPLDTEAFQRRLSSTKRRNGRQCIRQVLDRAEEAKQASIVARETAFLQIEERRKCIFYKHQHLVEIKRREESLDRAIRWSTIVVCHVFLAALMQERRVQEAMNTLSFLMAPMVRRFLGLRARCRETEQLTRSHLSDIPFPYPHIIQSMSGTFFEGWPSVLLEKLVEKVKPCYLRKGSYLMHEGDVGRVMYMVTLGAVSIVLRKKGPDKRRTKDNSIGVLQIQAPCYAGEFALVCKEPRSASIICETDIGYWAVSPEDYEDVVKYLSPAVASKQREATDVRRRQNLQRFFPLHVAFLRNFPYFAQFSDNSLLRLIDSVEPIVLHDGDYLFREGEMNSSTYFVQDGVAVLRDHDGTQRKVLKGSCIGVFECSCGVNEPKRSSIVSVDYCDIWRLSREPLIEIGMSEPAALLHCRSAAKRDRASEMHKDKVALQFFRKDPYMSFCCPGSTLANLFEASTPTVFLNGERLALMGKTLNAVTVVMSGVLDITMSRNAEHTTVRVHVAPNAVSNATLRSASAPFRGLSRVIGAYEFASSLSQYVCTVTSVGLTEAFVIERAQLDTKVPVALRGMIHDTVSSRECVSRAYKLENAGLLYNDEALSFVRLYRELRNAERETRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZZ6</accession>
    <name>A0A088RZZ6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromatin-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_312860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701670.1">
        <property type="nucleotide sequence ID" value="XM_010703368.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22577712"/>
    <dbReference type="KEGG" id="lpan:LPMP_312860"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310036400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_312860"/>
    <dbReference type="eggNOG" id="ENOG502SEBD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273749at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1255"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1381"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1798"/>
            <end position="1837"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="132"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="272"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="538"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="912"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1438"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1514"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1619"/>
            <end position="1708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1260"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1391"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1406"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1821"/>
            <end position="1837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1951" mass="219770" checksum="D6DD1A07F88D9792" modified="2014-11-26" version="1">MLTHTARSRHISSRRYSESPISVGRESGLLKGSHGLATRFEVCRMEELAKSLQQAQAAVLGIQDDLALLRAHVEEEEERGAGNVVKASAVGLETGVTLTNPYYVDLHTTVHRRQEAASLLLQRCAHLFYKQFGALEEKAERLENVQAKEKELQAAKKSMQRYFDAHATELAEERDSNAVGLRLEWERRQHLEDGIVCLDLKRRRQRLAHSVLLMWMKKAMMCHLAREYTRRRDATRETYESATCYAFVQQRRVTASQRALCTWRSRLQERRCQRLKTVATEAEKRAQFFREELTAIQKTLRESFRMGISECDQVATASPTHEQVCAQREDEVQRLRTALRDITVEFSERTRTYIRQQEGTEQVFGRKEVALRDTICSLQATLTVERQAHAAFTQSSELFVSHVNSYWQAQLQELAEVVRRKEEYTHHTILGLTGRLQHRHISLLKEMAKLARDVDTLAPLSEQCLRLENAVAESEQLLKRSKASSQSWERHCKAAHVVEALLTDRVVSADSAVLRARSFIRWLGRSHNASSEKLQHSIGTLSDNLQTQRRELRVQQQELSSRHQAEVARLRDEREQLRNANVRLQSELESTARKQRERDGAYYDSEVRNGELSAALLREKMERRGVEEKWWGSRASGLLLQEAQQRLRIEAQEGQWWTALLMRESKVLKVWTASLQCDVVQLTAVCEGWQQHCHQLETAHAAERKTVAGRTACALERGVLHAHTLVIWASWRGWAQQKRAVTAVEARSSESRREMIERHGKGMARLHTSHDIALQRLQREHTLEKAQLQSIHQERCAALRRAQTEEVAQLSERHAQQLKIAQTAYAADVAERDEHADAMQEQLSHLGLLVVEYCGQATYSRWRTWAAVRQAQRSAQQRRRLMMRIGEWHAVRTVMMDDCNAAKHSFWTAATIELSREREVKARRQAQDLAQEKELCRSQQHKLQAAKEAAEEEACHLRGELQHARTLYDAEVQYTERLLHTTTEERRAHRSTLAFTARMSEWRELAHCSVVEHQAAAIQAFMEATGLFMAKRPATNRAELTAYAAQVEEEPNARASRAVASSSGKVDAEKARVSECDSVVDVSECAPGECEADANDVGVSTGDEDGVCSSPCPIAVTRQPVEVIPEELLSRLQSMERYVNVAGDAREAEYHTDTTSSEQCGPLLSESFLGMLSPLPQPTAVANLLAEQTNVPFKVCHLLELVRLAALRGAATHKREHADELANIQAMRARSEEALARLRETMECLLAEQRSLAEEMHADAQQQRQQHSTSRAADSAQMSPALTKAWPERLSALSDRYTRVLGALFTANSRPQETLYNVKGMLAEANVLSEGLLQNFSEIVHEMVQLQAELLPQAHAARVLYQSGDEPDVTLPAGTEATVGAVQPSSPEPRALSLAATPSSSPVHPENSTHTACAQHSTSGATTCLATSVSPVGSTPEKRGLRDRVRFLEKLLVEAKVQLAEAKSLTGVAHRFTSLHMASVQAQVWAAQDAEDFSQLALTKEQLLVLYGASESTTRTLMTAMREYETELRRTQAEMSQQLRTACVAVEEKLQVRHRVDVERYEVKMRTLSESLAAAAKEQSEAEARCGELERQLKSETTTWAEKYSRDTELIRQSCLSEIDELTNHQRLLEDELQQCRRVAQSAIQQAVDRQTELLRLEHTEQLRRSERNVARLATEKALLEDRLRAIAADCERQVQQERSAVERLQHRLADDVGAVAEIACIATLASWEIHLVDIIELYVRCAADKAAWLAACAAGLVVKEREQWETEVMQLRERVALLQEASGAAPVPLARDGSFHQASTNLQRSSRKSTPQHKADEDSSQSLTLSPLPRRSNQGVSSAKVDVCIAARKASAPRTSRRAVSSPPAAEMYRETRNAPPVDSTGTTPTRCRSLSIDSLELSQSFLRYSKMLSDQRTRNATRLERASALAAEVDDLLLHGAQLSHSVASLNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0L2</accession>
    <name>A0A088S0L2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_343170</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702743.1">
        <property type="nucleotide sequence ID" value="XM_010704441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0L2"/>
    <dbReference type="GeneID" id="22578822"/>
    <dbReference type="KEGG" id="lpan:LPMP_343170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340038100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_343170"/>
    <dbReference type="eggNOG" id="KOG0764">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269120at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015215">
        <property type="term" value="F:nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044712">
        <property type="entry name" value="SLC25A32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45683">
        <property type="entry name" value="MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="21"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="121"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="222"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="328"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIO01943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="362" mass="39751" checksum="A6E6B59189C8B869" modified="2014-11-26" version="1">MTQSFSSSLNGSSRCVSAKNEHPWMHGAAGVMGGSTAMMLFYPLDFLRTRMHTIHQGSRTMPLRSAREIVRQEGLRGMYKGIGVSVISHSVGWGLYLLSFRAAQQRITELLGGKVEDFMFEQSSLDFMSACVAATITGTVVTPLHVIKTRRQLCDANHLPNCVRAQPLPPGFAGVRAIVRREGWKAMFRGLGPQVLLTGNTIIQVTIYEWFRRHMFTNHENPSPLQVALASGFSKAVACTLFNPLEVVRTCLQDHRNHGRAEFKSMWTGLQTIWRSEGLHGMYRGLPVNVARVIPTTMMAFVLYEKSLWAIRTTYEMAESLHTAGAATSSASNGVKGGAAGSNISTASNSKAGRSVGQPQFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0Y2</accession>
    <name>A0A088S0Y2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L27, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_322830</name>
        <name evidence="6" type="ORF">LPMP_322850</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701968.1">
        <property type="nucleotide sequence ID" value="XM_010703666.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701970.1">
        <property type="nucleotide sequence ID" value="XM_010703668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0Y2"/>
    <dbReference type="GeneID" id="22578024"/>
    <dbReference type="GeneID" id="22578026"/>
    <dbReference type="KEGG" id="lpan:LPMP_322830"/>
    <dbReference type="KEGG" id="lpan:LPMP_322850"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320034600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_322830"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_322850"/>
    <dbReference type="eggNOG" id="KOG3418">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="257182at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06090">
        <property type="entry name" value="KOW_RPL27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.770:FF:000002">
        <property type="entry name" value="60S ribosomal protein L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001141">
        <property type="entry name" value="Ribosomal_eL27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041991">
        <property type="entry name" value="Ribosomal_eL27_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038655">
        <property type="entry name" value="Ribosomal_eL27_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10497">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01777">
        <property type="entry name" value="Ribosomal_L27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="4">
        <location>
            <begin position="4"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO01168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO01170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="134" mass="15309" checksum="28DBAF450DCC5C9D" modified="2014-11-26" version="1">MTKFLKPGKVVIVTAGRYAGHKAVIVQNSDAATKERPYGRALIAGIKKYPKKVVRGMSKQTIARRSQVGVFLRVVNHKHFLPTRYNVDMSKELRGKINVSDASKRSRSKKLVRRVFQARYNAGSSAWFFQRLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S121</accession>
    <name>A0A088S121_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_344790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702898.1">
        <property type="nucleotide sequence ID" value="XM_010704596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S121"/>
    <dbReference type="GeneID" id="22578984"/>
    <dbReference type="KEGG" id="lpan:LPMP_344790"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340055700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_344790"/>
    <dbReference type="eggNOG" id="ENOG502SBQ2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267358at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="1001"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="1001"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="216"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="390"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="445"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="621"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="741"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="825"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="356"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="445"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="474"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="635"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="656"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="744"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="867"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="904"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="925"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="936"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="993"/>
            <end position="1002"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO02098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1028" mass="107690" checksum="ED9CD3819C0B9A0F" modified="2014-11-26" version="1">MSGVDAHGKAMGEAQSDRPVSSSSLTAASRATPNPTAADTGTAAHAGGSPVDNETDEHVPPVIAHVRKNFGVLAPTIEPFIYRSGCLNKSVVDVYNNLSRNYIAIVDAALKQVGFEEFSMQMQIMLTQILSEEFGEDTEYLVNTILTYTGADSLFVSLLSKSMLDQVITYAQSIMSGSMYGMGYNMQGGGGGGGGGRGAEGASNSYYRGAQQRHGYRSVGENGSPHDPRGNSVTASSPHHDGAAQQKPYRSSGLAPQPSDPGRERSSDDLRANSDVLFQREESREWGAGSGPHRGATAMGGVHVDSGAAPRGVGAALMSGMGAGATGRTEVSVNKSMSDTVSGAGVISRHPHHHLSSSAAASVTSSKSPSMERGAMNVIPQHNLLMPRMSPASNQPRVPTPGAPNVSQPTTVSPMPTIGRGGPGIPMHHHHHHLGIGAMATNSAPASDWAGSNTASGSTSNINPTGQHTLTPPSSQSASMQQHQTQQIQQQSQQQSQARTMNIPAPLSVQRRTEKNAVVATAAAAAATPAAAASSSAATAPANGSAPANSTSTNSNSAVAEAGVALRTISATLGGNANVPAPRGAQSLAHHQHHIPLSHHHHHHHHFAAPPPAVTAAVQLPSATQSQPFTEERVAAASARSTSSPAPEVSLPAARTCSSTPASVTSAPAATNAPTTCAPPPALRGVGRIPIHHHHHHIHVMVNKVEVSSSLPQRLPQQMPVAPQLQLQSHPPQRVATLIDGHEQQQQQERTNAANGRWPNHKEELRGMLLTARVSESAITHLLTDVNIEELRGLKYVDFEKKLRGGIPLMLDRQRIRQVLFSSVAVPGQSSDSDEPAMRFHRKNTTSEVGAEEEAGGPGLPRRPAVTSSGAQSPVTPYQSLPMSKAGVQVPQPRTKMQQQQQQTLQSINGGNTATSPADASFSSPEKETEKRESGTKTGSTTTTSGAPTSPVRGPTPAPSPNSSYSPSTRNEETEDNREEEQRRGSGRRGGKRGGLGRGGFGPSRVCRFFGTAEGCQYGDKCHYVHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S148</accession>
    <name>A0A088S148_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_323840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702065.1">
        <property type="nucleotide sequence ID" value="XM_010703763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S148"/>
    <dbReference type="GeneID" id="22578125"/>
    <dbReference type="KEGG" id="lpan:LPMP_323840"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320045700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_323840"/>
    <dbReference type="eggNOG" id="ENOG502S23R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277341at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO01265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="135" mass="15067" checksum="715FCCBC8899960B" modified="2014-11-26" version="1">MVSKTRKQRQKKKATMQANGGVLPLVVPSVPKSVHLKKTRPSMKGKMKIRLGLESPIDIYNGFDERKGVLWRCPSCGKECRVVGFCVDCASGVKSKTHTGQLMRRASTKKDSVQTRAPKLRIKAKSKTMKLKGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1D5</accession>
    <name>A0A088S1D5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein kinase, putative</fullName>
            <ecNumber evidence="8">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_344480</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="8"/>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702869.1">
        <property type="nucleotide sequence ID" value="XM_010704567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1D5"/>
    <dbReference type="GeneID" id="22578953"/>
    <dbReference type="KEGG" id="lpan:LPMP_344480"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340052800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_344480"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="251"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO02069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="284" mass="30132" checksum="37A25E099DDB6419" modified="2014-11-26" version="1">MVMTPSPSSQLPSSDNQQSDWTRRIRKSDVYPSSLGAICARVEALRCRWRDGEAANIVPITQAVCSPLYLRLDVDKALALKLLGPAAEYQQCSAPMGERDAALCVLSVAQLLSRLHAEGVVHGHVQAGVVLHHTSDARRVVVTECELPMSALVPHGGVGSDARQCAAPEILRGDPYTGAADVWGLGVLLVQLLRGPLKPLCTADLENSDLLSPFISALSPGAASFVLPCLKSAPQARPLLLEVLQHPFLSALPMDGNEDGDEQGSDDSSTSEGEELEGSVADSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1E2</accession>
    <name>A0A088S1E2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Katanin, putative</fullName>
            <ecNumber evidence="7">4.1.1.65</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_344530</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="7"/>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702874.1">
        <property type="nucleotide sequence ID" value="XM_010704572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1E2"/>
    <dbReference type="GeneID" id="22578958"/>
    <dbReference type="KEGG" id="lpan:LPMP_344530"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340053300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_344530"/>
    <dbReference type="eggNOG" id="KOG0267">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251605at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008352">
        <property type="term" value="C:katanin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007019">
        <property type="term" value="P:microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028021">
        <property type="entry name" value="Katanin_C-terminal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19845">
        <property type="entry name" value="KATANIN P80 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19845:SF0">
        <property type="entry name" value="KATANIN P80 WD40 REPEAT-CONTAINING SUBUNIT B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13925">
        <property type="entry name" value="Katanin_con80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="50"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="93"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="135"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="177"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Katanin p80 subunit C-terminal" evidence="6">
        <location>
            <begin position="418"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="340"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="310"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="401"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO02074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="589" mass="64196" checksum="50AEB88A659CD669" modified="2014-11-26" version="1">MFSVSEHRLPCDALYSRIGASRSKPLVGFGGRDASIHIYPFMGYTRTAWLQGLTEPITALAFDPDQTSVVGGSDAGKLQMWDIESEEVVRAFTRGHVSTVTGIDVFRSGQFFATVSTDRVLRIWDVRKSSGRQSYKDATAPLCAVQFSPNGRWVATGCARGTVRLYDLVAGQIVHKFELHSGAITSLHFHPDLYYLVVGSGDGTVSVWDLDSFEARFHSSSQHTPIDAVHFSGTRLLATSDHNLRIFDMSNLSDRTAVSLEAPWIMMSDVAYAGAMDEAWFVETAGSTAMKCKLSLRGIHHPGEEAPRAPAAPPASAPAPALPPQRVPVAALNRNNAILADAQKKPVNGSRLSPMDSPAKATGNDGAERTLRGETSAPSATTLPRLALSTAGPSFPPTPAPLSSAEESELEVLQQLSREHGTVSATLQGRLNTLRAVRTLWTQNQSEAMVHVRRFCEDGQEFGPLFDVLTVLQQPRMKEKMLTESIASVVDLVEIALKTDYEPLILLGLHTLRSIATKFRARVEEAQRRARASQSTGYNDPLGMNQHQHIAKKLHDCCPIVFVLAERCDNVGEEAKAVLPDMPPPPRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1M9</accession>
    <name>A0A088S1M9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">DNA polymerase</fullName>
            <ecNumber evidence="20">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">LPMP_331780</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19 20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 20">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="20"/>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702270.1">
        <property type="nucleotide sequence ID" value="XM_010703968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1M9"/>
    <dbReference type="GeneID" id="22578331"/>
    <dbReference type="KEGG" id="lpan:LPMP_331780"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330024800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_331780"/>
    <dbReference type="eggNOG" id="KOG0969">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2414538at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05777">
        <property type="entry name" value="DNA_polB_delta_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05533">
        <property type="entry name" value="POLBc_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.342.10:FF:000016">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000004">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050240">
        <property type="entry name" value="DNA_pol_type-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025687">
        <property type="entry name" value="Znf-C4pol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322">
        <property type="entry name" value="DNA POLYMERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322:SF23">
        <property type="entry name" value="DNA POLYMERASE DELTA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zf-C4pol"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
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        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA_POLYMERASE_B"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 20" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 20" id="KW-0235">DNA replication</keyword>
    <keyword evidence="17 20" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14 20" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15 20" id="KW-0408">Iron</keyword>
    <keyword evidence="16 20" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6 20 24" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 20 24" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 20" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 20" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="22">
        <location>
            <begin position="171"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="21">
        <location>
            <begin position="471"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="domain" description="C4-type zinc-finger of DNA polymerase delta" evidence="23">
        <location>
            <begin position="940"/>
            <end position="1009"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF14260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="AIO01470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1032" mass="116675" checksum="7A9B919A06A496ED" modified="2014-11-26" version="1">MSSSTLLQWRSIMRASLPAAYLDKHLCFQLLDCCQTKGNPHETVSRVRHTEVPVVRLYGVTAEGFSVLVHCYNYEPYLWIEAPRNWLPVHSQGFVRELNNQLSNQTRLQDTVVRVEVHQRRSLMYFKGGQLVPHLKIVVQLPQHIPKLRSLLSDRGVSCPGAWDGIRIFPTFESNVIFPLRFLVDNEIGGSNWLTLTSGKFLSCPLKTSTCQIEVACSHEDVQNHEPLGDYLSIAPFRILSIDIECQGRKGLFPEPEHDPVIQIANYCVEYGHESEPLTKTIFTLKSCAPIAGAQVFSYETEADMLLAWATFMKALDPDILTGYNICNFDFPYLLNRATALKASDAFHYWGRQVHERTAARDKKFQSKQMGNREYTELTLEGRIIMDAMVVIQRDYKLRSYSLNSVSQNFLGEQKEDVHHSIISDLQQGDEETRRRLAVYCLKDALLPVKLLDRLMCIVNNVEMARVTGVPVGWLLERGQQIKVFSMLLRKAQKKKLVVPTVEYTGGSDRGYEGATVIDPIKGFYNCPVATLDFASLYPSIIIAHNLCYSTLVRPADARLYPEDALDRSPTSDVFVKKDVFPGILPEVLQDLLAARKHARAMMKDVPMHSLEYKVLNGRQLALKVSANSVYGFTGAQVGKLPCLEISASVTAYGRQMIDKTKNLVEQLYPGTRVLYGDTDSVMVKCVTDEKASDKERLQAAMDFGIEAAERVSSDFLKPIKLEFEKVYFPYLLMNKKRYAGLLWTNTDQFDKLDAKGIETVRRDNCPLVARMVSGVLNRILIHRSVESAIDFVKGTISDLLLNRLDISNLVITKAFSKAEDEYAGAQAHIALVERMRQRDPASAPTIGDRVAYVIIKAAKGAKAYERSEDPIYVLDNNIPIDTQYYLEHQLAPPILRVFEGVLDDPSVLIKGDHTRHIAISAPSKNAGGLMRFVKVQLQCISCRAVIKEGALCDNCQEKAPEVYGKIMAKRNHYEAIYSQVWTQCQQCQGSLHQEVICSSRDCPVFYMRKKVQKDLHEQQALLDRFGVVDDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1N2</accession>
    <name>A0A088S1N2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nascent polypeptide associated complex subunit-like protein, copy 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_040720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="AIN95396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703718.1">
        <property type="nucleotide sequence ID" value="XM_010705416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1N2"/>
    <dbReference type="GeneID" id="22572031"/>
    <dbReference type="KEGG" id="lpan:LPMP_040720"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040015900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_040720"/>
    <dbReference type="eggNOG" id="KOG2239">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3169036at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005854">
        <property type="term" value="C:nascent polypeptide-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22054">
        <property type="entry name" value="NAC_NACA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14358">
        <property type="entry name" value="UBA_NAC_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000006">
        <property type="entry name" value="Putative nascent polypeptide-associated complex subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016641">
        <property type="entry name" value="EGD2/NACA0like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21713">
        <property type="entry name" value="NASCENT POLYPEPTIDE ASSOCIATED COMPLEX ALPHA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015901">
        <property type="entry name" value="NAC_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAC-A/B" evidence="2">
        <location>
            <begin position="29"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="174" mass="18486" checksum="3A37E865921DE4C2" modified="2014-11-26" version="1">MTAEEVQNVAAMADDEVPTLEAAEVPQNAKQSKRYAKAMVKMGLKPELNIMKVNIRKVGSLSFAMVQPEVYRFPGTNTFVIFGEAQLEDTSALAQEAAARAAVSGAAATSSDATASVSAAEDDDDDDDDVGAGDLDEKEINVVMSQANVSRKKAIKALKNNNGDIVNTIMELTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1S4</accession>
    <name>A0A088S1S4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NUDIX hydrolase protein, conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_350290</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702969.1">
        <property type="nucleotide sequence ID" value="XM_010704667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1S4"/>
    <dbReference type="GeneID" id="22579058"/>
    <dbReference type="KEGG" id="lpan:LPMP_350290"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350008000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_350290"/>
    <dbReference type="eggNOG" id="KOG3069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262892at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="NUDIX_CoAse_Nudt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF11">
        <property type="entry name" value="MITOCHONDRIAL COENZYME A DIPHOSPHATASE NUDT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="8">
        <location>
            <begin position="66"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIO02169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="307" mass="33134" checksum="7CA3C6B509239F46" modified="2014-11-26" version="1">MIRTAAAAAHLPQSAQGWVPLLKQALSFPIESVAFPSHFCLHTFSDGSTTTTGFSPQKTPVKLTTPRQCAVLVLLSPTTTGDGFQDMCITLTKRTETVSSHKSEMSFPGGHAEADETPRNAAQREALEEVGLLPSEYEIIGSLTPISTKSQHMCVTPFVAVATKPVQPHRASPEEVDSLHYLHLSTLLLKASTSHARVIKYHSLTSKRPCFFPCFFASPVQMAVSPAVRRSPKAAVVMDDCGFDPMLPEDFPGELVWGLTSLMTCELVARVAKVIVDAPEANSAVEVNALLIPSNVVARDPLVDSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S271</accession>
    <name>A0A088S271_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Universal minicircle sequence binding protein (UMSBP), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">HEXBP</name>
        <name evidence="4" type="ORF">LPMP_351690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703106.1">
        <property type="nucleotide sequence ID" value="XM_010704804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S271"/>
    <dbReference type="GeneID" id="22579198"/>
    <dbReference type="KEGG" id="lpan:LPMP_351690"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350022900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_351690"/>
    <dbReference type="eggNOG" id="KOG3070">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3267956at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000044">
        <property type="entry name" value="Putative universal minicircle sequence binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000052">
        <property type="entry name" value="Putative universal minicircle sequence binding protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000053">
        <property type="entry name" value="RNA recognition motif domain containing protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000039">
        <property type="entry name" value="Universal minicircle sequence binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051714">
        <property type="entry name" value="Znf_CCHC_NABP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23002">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="72"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="170"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="201"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="232"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO02306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="248" mass="25710" checksum="4B2FCE33E4BA4507" modified="2014-11-26" version="1">MSETEDVKRPRTESGTGCRNCGKEGHYARECPEADAKGDERSTTCFRCGEAGHMSRECPNEAKSGAAGAMACFRCGEAGHMSRDCPNSAKPGAAKGFECYKCGQEGHLSRDCPSSQGGGRGGYGQKRGRNGAQGGYGGDRTCYKCGESGHISRDCPSSQGGYSGAGDRTCYKCGKPGHMSRECPEAGGSYGGSRGGGDRTCYKCGKPGHMSRECPEAGGSYGGSRGGGDRTCYKCGDAGHISRDCPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2P2</accession>
    <name>A0A088S2P2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MORN repeat-containing protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_353890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703324.1">
        <property type="nucleotide sequence ID" value="XM_010705022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2P2"/>
    <dbReference type="GeneID" id="22579417"/>
    <dbReference type="KEGG" id="lpan:LPMP_353890"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350046900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_353890"/>
    <dbReference type="eggNOG" id="KOG0231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270720at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.110.10:FF:000022">
        <property type="entry name" value="MORN repeat, putative"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215:SF14">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="35858" checksum="0796768F8A29DE0B" modified="2014-11-26" version="1">MDAIKTYTYKSGAVYEGTFDGNVRSGRGHWTHPQGETYEGEYDDNRQNGLGIYIFSQTGKKYLGNWAAGQMNGEGLYFFNRDGTAYYFGNYSKDKKDGDGHYMYETGVMTTQKWDMGTLVREEEAPPSEIVECAVRIKKLMDAVRAVAPKEMGEMPPPSEVRTFQFPSGATYTGQYFGTKKHGRGYWLHPEGDSYEGQFDNNHHSGWGVYVIGRSGKKYVGHWRNGKMNGIGVYFFNPQETEFYVGLYRDDVKNGRGMYHFAESGASMVQMWENGVLRQETEADKATEEEYEAGIRKIIETVKPFAPNYEPVGFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2S4</accession>
    <name>A0A088S2S4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_342540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702680.1">
        <property type="nucleotide sequence ID" value="XM_010704378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2S4"/>
    <dbReference type="GeneID" id="22578759"/>
    <dbReference type="KEGG" id="lpan:LPMP_342540"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340031500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_342540"/>
    <dbReference type="eggNOG" id="ENOG502S3B8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272390at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="528" mass="57050" checksum="D26A0B490EBBD683" modified="2014-11-26" version="1">MKVAPVYRRVLKQLHVACQIRPHYVQDIRFLLSFPLHTTGNGLSAVAPSPLSSSRILKSTSTVGPIQAGASKSSRSPPCQTASRDLVDEHLQRPSSECYPIDTTTLFAMCYADLHNAVREAAPAAGDMNPVAMQIVRYRNLLWLQERLVRVLSSKTRQLLATSLSISRGPTEHDFIPDNIFEKNASPSSSGGGGTTSSTTPVAQLTGPGAIAGGDRPSKAATTTAVLTHSSAEKTPGDAAESFAPATADGSLAEAVEENDPDIVYSAGAIGQQQEVFVLRHREAFPMAAQFLAGFPTVTVAELAACAHQRAALMQLVRERFPKTLTCQDSNVKLSVSLEPYDVEYTSKEHAGMGYFAAAHRQFRVRFSLEPLSPDGTGAERAEVLVVNSYFVRLDMELMQLVEEVGYLHSSDVLRMLRERDYSDHFSDFIGSGVAEVLGEGVLAEPSVGKRAATTTSSDKRTKSHSSTTTHAPATVAAGSRVFSLYFVNHSDAPMVLKGLLYYKLGKLRHLAHAPIQCIPFGFLLMEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S375</accession>
    <name>A0A088S375_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CCDC81 HU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_355230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703454.1">
        <property type="nucleotide sequence ID" value="XM_010705152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S375"/>
    <dbReference type="GeneID" id="22579551"/>
    <dbReference type="KEGG" id="lpan:LPMP_355230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350060800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_355230"/>
    <dbReference type="eggNOG" id="ENOG502RXMV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269134at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040673">
        <property type="entry name" value="CCDC81_HU_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028034">
        <property type="entry name" value="HU-CCDC81"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14908">
        <property type="entry name" value="HU-CCDC81_euk_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18289">
        <property type="entry name" value="HU-CCDC81_euk_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCDC81 HU" evidence="1">
        <location>
            <begin position="22"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="CCDC81 HU" evidence="2">
        <location>
            <begin position="125"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO02654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="29553" checksum="2BD30A926ED977CE" modified="2014-11-26" version="1">MTQSSSCSGRVCRCCYGEIAEVVTHVDGLYTLQTKRQGTAHQLNVIWRVLGEQLEEMLIKKRSAIVLDFLHASMKVQHITLFNNSTAIQLKPQLMLLPDFTSKFHLKNVLEMHDAHYHATVPNAVSYLTIASIAGTNRFVVEAAVKDSVREIGKYLQRNAASTLTIDIGVGFLEFKDRTYRMKWSPEFLARMKASVGAAEVVTPYDPPSMTVGGPTAPCRFQKGCTSENRLQSQIRDTVLAESRLTAAELNDGMGRSSYRRVHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3C6</accession>
    <name>A0A088S3C6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_344810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702900.1">
        <property type="nucleotide sequence ID" value="XM_010704598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3C6"/>
    <dbReference type="GeneID" id="22578986"/>
    <dbReference type="KEGG" id="lpan:LPMP_344810"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340055900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_344810"/>
    <dbReference type="eggNOG" id="ENOG502RYNM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277767at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO02100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="347" mass="38914" checksum="A9A7993BF72003A1" modified="2014-11-26" version="1">MSVYARVFFKNVGLPVVGFGIGWAGFTVVEQSGLLTEPMQRWLNVHNLKLQLYTQRLLPTSVVEKYGCPADTLRSTIELLEKGYNENEISDRMSFDEVLRECAVPEQVAYLEEHASEEIPYFYIADIFHSWANLNVHSFVRQQQSLMDTAANTTTPTSPVEGAAASFALVLRNDEAFDSDVLCSALWEKMIHSVIPFDVSIRALCVLAVNNRANARRLARLSSPERVVELYNEYTGKIQANQQQSSGPDVVPPEEVAAATLFFLRAVNDASIQKRWIPLPGALSTDLYPLAWKVQREPWCRAFGNLTPTVTHATSEMAVMLVDVMNERLRCVELRKAETVPSQSLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S4G0</accession>
    <name>A0A088S4G0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleoporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_353800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703315.1">
        <property type="nucleotide sequence ID" value="XM_010705013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S4G0"/>
    <dbReference type="GeneID" id="22579408"/>
    <dbReference type="KEGG" id="lpan:LPMP_353800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350046000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_353800"/>
    <dbReference type="eggNOG" id="ENOG502RF63">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="240828at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1076" mass="119008" checksum="62BB6C61EA72D109" modified="2014-11-26" version="1">MVVGQPVSTAQGSSPSLSTSLQEPFLRYDPKECWRSANGPVVEEARPMLRNRYFNMDHLALWKPSLLASLGEKCHRAVYVNEYHALLCSRRLVLVHNNGRYIIFPPFCDTLNDAYAERVSEKCTLVLAAVASGVHVALVRDSDSQKPDTLQSVFCPTASAVACIHHLGTNLYGLCCENCSVESLAVTLNNMHLPHPGLHANVLPNRHGWVQAAYDYLSPKRYVHSLFDRHNGYLVMLSSRNVSLWMYSDAFHLQLECSTALPREAVLAIVPLLQDEYGETEVAVLITGSGGRVPVHLRTTTGKRGNSWSLSLGELRGLPCGVTNTMVSLACACDSSLLLADQRTSSLLLVTHCEPFCEAPYSSITHVVTQHFLGKPICGVGVEKSVRDGGSFITFTVYCGDSTIVRLGRMPRGQLLQQYFAATVAGGIDALCSLEPQVRVDLLLDAVLCGLPISYLSQFLDPLLHPRAATVCALRLSDGARGIIRHTMRGLRELSRSCLSFHYWGLKEELAQSRSRVEKSCTILTEVLNRGGWLDCPTRQQLAWDGDLLVRVDGTLTDTSAVDAQAEVLQQLLSSVRHATTIAWLYGLLLETGATYRFSDRLEDLLWKSDPVGVQVSLCMNLLERRNKGITDKLLQKEYVLPQRCRLAVTLLSLVLDKSLEPVMTYTRRHILDLVEYDLLSYTTDLLESSFPTSQPRIRLLVYRYPHNQSVSSDILSMVEAISSTSELYNTLVTILGDAACDGELTAVLLDWMERHTLADHRILTFAKVVADMRLCVDPAHTLTGRFFSSVKQQANGNAQQAALRFAELARSDLSVPLDGRLLAIEHAIAAAPSDGDRLIQFLLLLQQQLARLIAEHLTVGKNLVSARGTVEADLQVLQEHYVTENFLFELAGRYKELGGCIIQLDLLKIHSDSAELLITNALTGVLTFLRAVGLSAPQAVQRVLREYLGTFQTSLPLFPFVEFLAFDGQSPARAIDELEKVGVPLLTIFDTFMSLLDGHRNPLFQIGDTVLALGQLVPKISPNVQHICAAHLLECSRSMLAGEQRAVVLSEKDVHTIKYIGDDMRKLSQRSQAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S4L8</accession>
    <name>A0A088S4L8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ribonuclease</fullName>
            <ecNumber evidence="10">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_130050</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the RNase HII family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="10"/>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697089.1">
        <property type="nucleotide sequence ID" value="XM_010698787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S4L8"/>
    <dbReference type="GeneID" id="22573115"/>
    <dbReference type="KEGG" id="lpan:LPMP_130050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130005600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_130050"/>
    <dbReference type="eggNOG" id="ENOG502S4TJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7462577at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF23">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51975">
        <property type="entry name" value="RNASE_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 10 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-2" evidence="11">
        <location>
            <begin position="1"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN96436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="255" mass="27719" checksum="03CE642260DC6D65" modified="2014-11-26" version="1">MAGPVGVAATLYRVSATPVRYTVGDSKRMKESARAETLEAMCAELSDAGVKGFLETTMRDGACCVVRYQQRQPLQAVSAVLVDIGVIHGRNILNATLEGMSAVCNTIVRSYNAVRGLQILTPLTCAILIDGNRVPWTFLSGEERQQVRMQAVKNVEARKRIGVDYPVLDGFGCTAVIKGDATVLSIAAASVVAKVARDAYVVTVMHRAFPHYGFDYHKGYCTAAHKMELARWGPSRFHRVDYAPVKAVLKAREAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S532</accession>
    <name>A0A088S532_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_140300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697264.1">
        <property type="nucleotide sequence ID" value="XM_010698962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S532"/>
    <dbReference type="GeneID" id="22573297"/>
    <dbReference type="KEGG" id="lpan:LPMP_140300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140008000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_140300"/>
    <dbReference type="eggNOG" id="ENOG502S8KE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="278326at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN96611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="308" mass="33813" checksum="6853A345F92C08B9" modified="2014-11-26" version="1">MQLAPPASRVVRQWSGIPASSLLLRRRTWTALAAATWPVSPCTSRRYLSQQGTQWLNKVRYGADNAPMMGSWDSAYGDDAMDTRKLYCKALVHASGGSRLARDWIAGYSALTSPDPSLIYTALQHDATEADVQELREHILGCLLAQESPRRGGCSGGSRENEVRAKFDMNEESEKEVVVPGAGDAAPEPAVAPNCGGQCNMHEGDDEDGASEATSPPITSESIRDAEHCLLQRSREVRCFMYDAMTASLFHSNNELRAVEAARRHTFSIGSNLFGLSFDELTALWRLVEAELLLKKEKVKVLGQPWGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S6X9</accession>
    <name>A0A088S6X9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mitochondrial biogenesis protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_181200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697954.1">
        <property type="nucleotide sequence ID" value="XM_010699652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S6X9"/>
    <dbReference type="GeneID" id="22574010"/>
    <dbReference type="KEGG" id="lpan:LPMP_181200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180015300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_181200"/>
    <dbReference type="eggNOG" id="ENOG502S6BU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273010at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13675">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13675:SF1">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="4">
        <location>
            <begin position="202"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="162"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN97301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="275" mass="31259" checksum="9AD42124BA75A6F1" modified="2014-11-26" version="1">MRACLHLTRVTRHQRHDKGGNAHNFPFDTLTKVYRDTMYVPQERYRGNPMHPERGAEALLSPVVPSRRSNVTNHVGNIGVMSSAATKLSEWMEQQQQQHPEKEHINDYEGIGHESATASCATPIVRRRAAPSSPSLVSSSAAVATEESHVDDEVIRRRLRTHLFSAKKPSERQATAGKPPTASPATTETGAASPRRSGVQVEILSVYRSMLREVSRIQDADTRRNLSAYIREEYDKQRDIPRKNIMKIEWKLNYSKRKLDELRAMGKDTKFTMMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S864</accession>
    <name>A0A088S864_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_202800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698483.1">
        <property type="nucleotide sequence ID" value="XM_010700181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S864"/>
    <dbReference type="GeneID" id="22574490"/>
    <dbReference type="KEGG" id="lpan:LPMP_202800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000010100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_202800"/>
    <dbReference type="eggNOG" id="ENOG502QTFU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277246at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="397" mass="42756" checksum="7A1D1E57AEB4BF47" modified="2014-11-26" version="1">MEAPSTLNSYLSLVDDFFRKTFREDSCLFVALKSRQYSESILGVNMFAKEAATISADAPFTPKMESGSKLASAAAPSVAEKTPTRVKNFLSLSPRMALHRDGTADGKMKVAYEFYLPRVCRLQQALTLSSRGTVTVVGNVKELMEGLTAGVRASVNTIMPASEDVTLGQIHYKRGDKYSSLAYQRNGLGSSNLLLDCGITFFNLLLGAGFERRQLSFLEQREGSGPLDVMYVGAGFTGVNWSIAAKMVRSNDAWSNARLALLQRLSSNTAVACQYNFDLVEAVAKVSLGFTQGIQIRVPTLIQTKSTAPILVSTSGGAPSSPLTPQVAEAALPVIPTWSTPVPFLVAAKAESDGNCSATLRGLFNNSIRWGVVVQKNLLDDTSVVQYGLTLSMECDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S9T6</accession>
    <name>A0A088S9T6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione-specific gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_221080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.3.2.7" evidence="1"/>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699108.1">
        <property type="nucleotide sequence ID" value="XM_010700806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S9T6"/>
    <dbReference type="GeneID" id="22575154"/>
    <dbReference type="KEGG" id="lpan:LPMP_221080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220014200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_221080"/>
    <dbReference type="eggNOG" id="KOG3182">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1933483at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061928">
        <property type="term" value="F:glutathione specific gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.10:FF:000019">
        <property type="entry name" value="Gamma-glutamylcyclotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006840">
        <property type="entry name" value="ChaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192">
        <property type="entry name" value="CATION TRANSPORT PROTEIN CHAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192:SF2">
        <property type="entry name" value="GLUTATHIONE-SPECIFIC GAMMA-GLUTAMYLCYCLOTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04752">
        <property type="entry name" value="ChaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="280" mass="31116" checksum="97867B2B3C52ECDC" modified="2014-11-26" version="1">MSSSADLSTRATRYHEQFGLPSFDDHVFVIFGYGSILWKQNFEFDAEYETYIKGYKRVFYQGSCDHRGVPGKPGRVVTLLPSEDKEERVYGKAFQLPADPEKLNSIFTALDTREGGYDRVQLTLFNARPTTGNLTTAPGLLASTPKSFRTESATRYNPPLRQNSSEVEAGDAEEVLDIRNHPNAPAVQPCKKVVCLCYIATEQNKDYVGEASTEMIATEILSCAGVSGPNREYLFFLADSLRTMGATDPHVFELDAVAKQLLRDREAEFSAGMQQPVTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SBR6</accession>
    <name>A0A088SBR6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_260010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699823.1">
        <property type="nucleotide sequence ID" value="XM_010701521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SBR6"/>
    <dbReference type="GeneID" id="22575904"/>
    <dbReference type="KEGG" id="lpan:LPMP_260010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260005000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_260010"/>
    <dbReference type="OrthoDB" id="10517021at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="297" mass="33725" checksum="9EE52173D12D4373" modified="2014-11-26" version="1">MFQLYPLPMTEIATLDTIVFQLLSKDVREEYLKPGVRWKSQFGTQIIYLGVQGGIPLSAEKDLTSAPLTETEMRNAFDAPRCSSFVSRIFPGLHTILQFLHSKVSVVEVDVRHTLRVTCKKKFGGPAVFYERSAPTRDAVLNEEEFSAKGYYDEQRVTTEVFLPPADKRPKAAYTLFRIQAVDPTKASCGPHKTIQVCRTHKGIEASIEYYKGSVDYVRVEERHVLKLLSCEAEIHVVKVEEYGARVPKKPKPVRVELRNPALSETASPRQHKLAWASFLALSVRLNEYLEIFSMTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SBU5</accession>
    <name>A0A088SBU5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L7, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_260170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699838.1">
        <property type="nucleotide sequence ID" value="XM_010701536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SBU5"/>
    <dbReference type="GeneID" id="22575920"/>
    <dbReference type="KEGG" id="lpan:LPMP_260170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260006500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_260170"/>
    <dbReference type="eggNOG" id="KOG3184">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276123at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000004">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018038">
        <property type="entry name" value="Ribosomal_uL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005998">
        <property type="entry name" value="Ribosomal_uL30_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_uL30_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012988">
        <property type="entry name" value="Ribosomal_uL30_N_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01310">
        <property type="entry name" value="uL30_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08079">
        <property type="entry name" value="Ribosomal_L30_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00634">
        <property type="entry name" value="RIBOSOMAL_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30 N-terminal eukaryotes" evidence="5">
        <location>
            <begin position="7"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="4">
        <location>
            <begin position="83"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN99131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="240" mass="27449" checksum="1E06DCE3D1484593" modified="2014-11-26" version="1">MPAVPAPESAIKRAAFKQQQTESFKKAVVASKAAKAALKKVAYSRGRRYSREYRGAEKKLVTLRRQAASHGNYYLEAKPKVAVVTRIRGIAKVNPKQRKILQLLRLRQIFNTVFVKMNKPIENMLRAVEPYIAYGYPSLATVRAMVYKRGYLKINGQRVKITDNQMIKDKYNNADVVCAEDMVNQIYTCGKHFRTVTHGLWPFKLAPPAGGMRQKRRHFVEGGDYGNRDTLINRFLARMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SD67</accession>
    <name>A0A088SD67_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Origin recognition complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_280030</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">ORC is composed of six subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ORC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700348.1">
        <property type="nucleotide sequence ID" value="XM_010702046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SD67"/>
    <dbReference type="GeneID" id="22576448"/>
    <dbReference type="KEGG" id="lpan:LPMP_280030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280005200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_280030"/>
    <dbReference type="eggNOG" id="KOG1514">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF23">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839367" description="Origin recognition complex subunit 1" evidence="7">
        <location>
            <begin position="20"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="79"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN99641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="457" mass="51818" checksum="26578E504A287598" modified="2014-11-26" version="1">MFVLLLFPFPYSWLHSVETRIAGEPEMKRSRRATQQEDVVRALKEGVQALSISSTLSTRDLVCREDHARAIQEFLEDDKYRTMQIFGMPGTGKTATVNFVLAQLASRRDPKPTAVFLNGFVVQKSADIYFTLHHHLTKARLGVAERCPVAQCASNIEKRFRHGWGDKPSSLCVIVVDEVDKILEKHSKGLFKVVDWLTLPYANCKLITISNSMELQLDAKTKSRLGVINQLVFSSYGTQELREILLHRVGAIEPKLFADQAVNQLCTQTASHYGDVRRLLQSASAAICSVVMRIQDGGFDVPSTDGIITLREIHSVVRQIFHDRFVEFITTMRMPVLFITVAVIGKETEELIRKRDLHCRLPLERLLAITQQAQRKCMDVSRPISRVAFLEEMELLRQVSLIEVCVGEDRIPIHSVEELLDCKEDVYVLLLQPYQMIVDSCRLHDAFGATYGAVLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SG35</accession>
    <name>A0A088SG35_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase m20/m25/m40 family-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_311760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00767.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701567.1">
        <property type="nucleotide sequence ID" value="XM_010703265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SG35"/>
    <dbReference type="GeneID" id="22577602"/>
    <dbReference type="KEGG" id="lpan:LPMP_311760"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310025500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_311760"/>
    <dbReference type="eggNOG" id="KOG2276">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="256211at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05682">
        <property type="entry name" value="M20_dipept_dapE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF4">
        <property type="entry name" value="CARNOSINE DIPEPTIDASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO00767.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="471" mass="50971" checksum="4E0A75A68F562840" modified="2026-01-28" version="2">MSADWAQVRKTVESEWEETIVPAISAYIEVPNQSPQFDPEWATNGLQEKAFDILIDWVKAQNVPGLTYDYITAEGRTPFLLIEIAGTEPTKNTVLMYGHMDKQPPLRPWAEGLDPHKAVVRDGKLYGRGGADDGYALFGAVTAIASLQRHGIPHGRVVITIEAGEESGSPDLDYYMEHCRERIGNVDLMVCLDSGSMNYTQVWLTTSLRGVAIGELTVQTLTESMHSGVAGGVVPDTFRITRELLDRIENCKTGEVTIPEAHCAIPPYAAKAAEGMTAVPFKEQFAMAAGVSTVPGDNVELAIQNFWKPSLTVTGANLPDPQIAGNVIRTHTTVKLSMRLPPLVKAEAALQAMKRILEADPPYGAKVTFKAVGAGNGCAAPELKPWLDKALREGSAEAFGNTYACQGMGGAIPFISMLIDMYPEAQFVVTGLLGPQSNAHGPNEFLHIPYAKGLTYSIARVVAAHFHNTPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SHH6</accession>
    <name>A0A088SHH6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_323960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702077.1">
        <property type="nucleotide sequence ID" value="XM_010703775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SHH6"/>
    <dbReference type="GeneID" id="22578137"/>
    <dbReference type="KEGG" id="lpan:LPMP_323960"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320046900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_323960"/>
    <dbReference type="eggNOG" id="ENOG502S2M5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269966at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003377">
        <property type="entry name" value="Cornichon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03311">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01398">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="183" mass="21242" checksum="5A29C061741E0F20" modified="2014-11-26" version="1">MRFIESQREVIHTLRFPLQHSATDRKRAYMFLLVYVLTIIAFGGNLFHFISGWIAATVLQVVMTILIMIYAFNINDYSDKSMSSMECERACNPLLDAYVALRAVQVVQALVLRSFLCTFLYAVVLIVTLFRIRQQKLYVDAVNLWREVSLYEREGFVFIAIDVMMIIVLLIVMVFSIVTKYSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SIH8</accession>
    <name>A0A088SIH8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_333340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702422.1">
        <property type="nucleotide sequence ID" value="XM_010704120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SIH8"/>
    <dbReference type="GeneID" id="22578487"/>
    <dbReference type="KEGG" id="lpan:LPMP_333340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330041800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_333340"/>
    <dbReference type="OrthoDB" id="273290at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="981" mass="106989" checksum="D66B5F4AFDA9C677" modified="2014-11-26" version="1">MNHSSSIPFDAFHVVTWSCFIEQDDPRMITCELRRELESAFEVYPYSAKCRQSLLSSLILWAGLARAQRHVIQWNSTDNINLGQGLIQHLFDLTAEMQGINTDTIYAALRAERHPFLKEVYKVQQARGVVDGMWRGSDRCATTETKRDDTRPTIPTLHTEPLMPMSPRSPTALRESQSREEQLPRPSAEIYPCVPTPLTNKASPSTTMLYPVGYCDNETLQKAADIRSGVLSAKLLKDTTACGPTKRPPVSLPSASKIVANHANDKPLRWKGDSAKPADVFAAPSLIRDSLLPESVPSAAIYRLIHAVDTAPSVSSTKGVVAKPLARNGEAKPTASSKFATRLPAKADVNPTSATKPKVAAAAPLLPAPSAAKEPTPYVPKKVTYVYTDSDDSDDVTSSAVVHDTNASASASGLALPTPVTEALLKYGDGKSADLMQAFWNDLPADPDGVSVWFGRCLAITEDDRQVPLMAAASPPLCLDKVKQRMQSKVAKRLDQLFQYLHAEAPTPLPPRNEVAALLSARDIEQLEAAKLIRPCKQSAGPDTVLAFTVVEKATTNARRRFLTWPRGSNQHTIDSGYESHIPLHHISTYLDAVNESCGIVQSIPGCFDQVLLPPDLQERFVFTDARDHRWCLTRLPLGHTVSMEIVQIIVSTLSGHPSYTLQSYAAANAVRIDVWVYTARLCGPAKDVQAASAALRAACDECGAIVTTSWRDVLTSDYNFLGVHFDHSAHEVSVASDILSRVDLPSVSISTRDLERQYTQLLFCSSTLRVAASGYYTVLTEVCHRLGVLQLHPQQLHTPSELLPGVYMQLQKWREAVLKNTPRHVEAVTSPSMSLFVVLNKENCQAVLVSQETQETWNASMELEDTLGTRVASVAVTRAVVCFQPCIEKGTHLKIKVIGGEAKGPNGKPIYESEPEDSIAVCIRTHLVARIFSFEVAYLKMPGSAGGVAGDTAACNDAQMGANRRLIAPPSSPPPTYTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SKI5</accession>
    <name>A0A088SKI5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LPMP_352000</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703137.1">
        <property type="nucleotide sequence ID" value="XM_010704835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SKI5"/>
    <dbReference type="GeneID" id="22579229"/>
    <dbReference type="KEGG" id="lpan:LPMP_352000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350026000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_352000"/>
    <dbReference type="eggNOG" id="KOG0823">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16534">
        <property type="entry name" value="RING-HC_RNF5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045103">
        <property type="entry name" value="RNF5/RNF185-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12313">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="13"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="67"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="129"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="233"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AIO02337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="301" mass="32734" checksum="9D93ACE6C92C7F1E" modified="2014-11-26" version="1">MASTSVPAMDFSCAICLDIATEPVVTRCGHLFCWECLDHWLHSAAGAPECPVCKGRVDERMSGDIIPLYGKGRQPAAKAGSDQGTTSAPATTATSSTSANKSATSVADPAQRAFFSRPSAYSFAPARNARNAAQGSSQHHQEPEQQQHHPRPSADRAPPHPRPQQRHQFQNVHINRGSMPLTMGSGIFFFSGGTGVLFSILIVAIWTLYHYAPWREWAQMSARWFNRLRGHPEPANTSQAEHEAAADRPNQARTQPAATHSASAVPLAEDPNDNASPPPIVRHLIISLFLVFISIQLVAYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SKM6</accession>
    <name>A0A088SKM6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucokinase</fullName>
            <ecNumber evidence="3">2.7.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_352400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.2" evidence="3"/>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703177.1">
        <property type="nucleotide sequence ID" value="XM_010704875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SKM6"/>
    <dbReference type="GeneID" id="22579269"/>
    <dbReference type="KEGG" id="lpan:LPMP_352400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350030400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_352400"/>
    <dbReference type="eggNOG" id="ENOG502RSFG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10257118at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24008">
        <property type="entry name" value="ASKHA_NBD_GLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003836">
        <property type="entry name" value="Glucokinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47450">
        <property type="entry name" value="GLUCOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47450:SF1">
        <property type="entry name" value="GLUCOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02685">
        <property type="entry name" value="Glucokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO02377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="411" mass="44172" checksum="F735837BB7ED7BDD" modified="2014-11-26" version="1">MVQTKEIALEQLALTLRGDASWSSGPIYVVCDVGGTNARVGFSQASQHDRSGLHIIYVRFKVTKSDIRQLPEFFDEVLQHLKKNLPDHGASFLRRVASGAVSVPGPVTNGQLAGPFNNLKGIARLVDYPVELFPKGRSALLNDLEAGAYGVLALSNAGILSDYFKVMWKGTQWDALSEGKPAGSTIGRGRCMVVAPGTGVGSSLIHYVGVSDSYIVLALECGSLSMSWCANEDSKYVQALAGYMASKAHAKGLDSTVAPIWEAASNGAGLEFNYAYAKEGQKASAPLKSAPEVAKLAKSGSDTAAIAAVDRLYKNLMGLTAETTMQFLPLTCVLMGDNVVANSFYFEKPENVKRLQARLHEHAMERQFKFLSRTTFLRQVSSVNINLLGCLGFGSQLSKSADQVVPTKSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4W7</accession>
    <name>A0AC62A4W7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3520130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="XUY36845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="140" mass="16007" checksum="CA7CCFC247151F79" modified="2026-01-28" version="1">MRRATLSVAVCCAQPAVALTPVRTIIAAKGIVENRIAKHYTNRTIEESKTERAEGIKKTLHPNPCNRKEELSHLTQHCSYEYVPEFQRWANDMMAVYSDPQGYGHDMAYHYHRIWKAKSLTRRGVEDGSGAFDVCRVHPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A564</accession>
    <name>A0AC62A564_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Paraflagellar rod protein 1D, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2920070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="XUY36942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="595" mass="69201" checksum="2AA3834CCECD1D06" modified="2026-01-28" version="1">MMSPEDATGLEAARKQKIHNLKLKTACLENEELVQELHISDWSETQRQKLRGAHEKGEELLASVEVGTKWNLMEAYDLAKLMRVCGLEMSQRELYRPEDKPQFMDIIGVKKVLQDLRQNRNKTRVVSFTQLIDNSIAKMEKVEEELRRSQLDATQLAQVPTRTVKMMEDIMNTTQIQNALASTDDQMKTQLAQLEKTNEIQNVAMHDGEMQVAEEQVWTKVQLQERLIELLKDKFGLIGKCEEENSQFKEIYEVQKQANQETSQMKDAKRRLKQRCETDLKHIQDSIQKADLEDAEATKRYTGNKERSERAIKENEEMQEETWNRIQDLERQLQRLGTDRFDEVKRQIEEVDREEKRRVENAQFLEIAAQHKKLLELTVYNCDLAMRCTGLVEELVSEGCASVKSRYDKTNQDLAALRLEVHKEHLEYFRMLYLTLGSLIYKKEKRLEEIDRNIRLAHIQLEFCVETFDPNAKKHADMKKELYKLRQGVEEELAMLKEKQAAALDDFKESEEALDAAGIEFSHPVDENNEEVLTRRSKMVEYKSHLTKQEEVRIAAEREEIKRARLLRSGGESAAAQITSGSLRADNAANAQLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5A9</accession>
    <name>A0AC62A5A9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha tubulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1320120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="XUY36983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="451" mass="49683" checksum="3D47FCCC1FBC5BF5" modified="2026-01-28" version="1">MREAICIHIGQAGCQVGNACWELFCLEHGIQPDGSMPSDKCIGVEDDAFNTFFSETGAGKHVPRSLFLDLEPTVVDEVRTGTYRQLFNPEQLVSGKEDAANNYARGHYTIGKEIVDLALDRIRKLADNCTGLQGFMVFHAVGGGTGSGLGALLLERLSVDYGKKSKLGYTVYPSPQVSTAVVEPYNCVLSTHSLLEHTDVATMLDNEAIYDLTRRSLDIERPSYTNVNRLIGQVVSSLTASLRFDGALNVDLTEFQTNLVPYPRIHFVLTSYAPVVSAEKAYHEQLSVADITNSVFEPAGMLTKCDPRHGKYMSCCLMYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKCGINYQPPTVVPGGDLAKVQRAVCMIANSTAIAEVFARIDHKFDLMYSKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGAESADDAGEEDVEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5B2</accession>
    <name>A0AC62A5B2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Heat shock protein 70, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3020130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="XUY36963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="659" mass="71525" checksum="2AB403526B56502D" modified="2026-01-28" version="1">MFARRVCGGAAVSAARLVRCESQKVTGDVIGVDLGTTYSCVATMDGDKARVLENSEGFRTTPSVVAFKGSEKLVGLAAKRQAITNPQSTFYAVKRLIGRRFEDEHIQRDIKNVPYKIVRAGNGDAWVQDGNGKQYSPSQVGAFVLEKMKETAQNFLGHTVSNAVVTCPAYFNDAQRQATKDAGTIAGLNVIRVVNEPTAAALAYGMDKTKDSLIAVYDLGGGTFDISVLEIAGGVFEVKATNGDTHLGGEDFDLALSDYILEEFRKTSGIDLSKERMALQRVREAAEKAKCELSSAMETEVNLPFITANADGAQHIQMHISRSKFEGITTRLIERSIAPCKQCIKDAGVELKEINDVVLVGGMTRMPKVVEEVKRFFQKEPFRGVNPDEAVALGAATLGGVLRGDVKGLVLLDVTPLSLGIETLGGVFTRMIPKNTTIPTKKSQTFSTAADNQTQVGIKVFQGEREMAADNQMMGQFDLVGIPPAPRGVPQVEVTFDIDANGICHVTAKDKATGKTQNITITAHGGLSKEQIEQMVRDSEQHAEADRVKRELVEARNNAETQLTTAERQLGEWKYVSDAEKENVKTHVAELRKAMENPNVAKEDLAAATDKLQKAVMECGRTEYQQAAAANSGSSSNSGEQQQQQQGDQQQQQQNSEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5T1</accession>
    <name>A0AC62A5T1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphatidic acid phosphatase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1820030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="XUY37114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="497" mass="54127" checksum="27CD5B71C199D756" modified="2026-01-28" version="1">MACPRMSPIGLLLPLALYFSSFRGTRVHSDLVYLHPPGASRHRSAPLPALSHAPHSVAHAHAQSSPNPLLLESGPCSATRRSAIPPSTASLPHPSLTRRQRAKRAKMGLLRLNEVLRFIFFFRLHDYLLCILCGLIAFGVGRVRPYCREFSWTDLSINFPFSKSPAFPTWTLFIISAAPLVVYVLGEAMRHCWLARRHGGILAYEPYAEHTLILMGSQRHGGDGAEMSMKADGNGSDFEAPPLALSSDSSKPQNLASGREPTQEVQVGSETAAVAPACHLSASPPPEKLCGSRGDDGRSSGAVAVSLAHAANSATQPQAVHLYTLAHPWQRFLLYTHMWVLLQAFSVALSVIIVNALKVYAGRLRPDFLSRLRNEGFNASSMGVDWCTVANEGRLSFPSGHSSAGFSAFVPLCFYVLHSLHAFRLSGVSLWRILIGLTPLILPITVAVSRTRDNRHNFDDILAGSLIGIFTALVAVRATMMVNYGTGQLTPRFAYYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5W4</accession>
    <name>A0AC62A5W4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATG8/AUT7/APG8/PAZ2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ATG8B.2</name>
        <name evidence="1" type="ORF">LPMP_1920230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="XUY37144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="127" mass="12850" checksum="EF18415DC49FEA1D" modified="2026-01-28" version="1">MSAYQSSNTAEARRAECARLQAKYPGHVAMVVEAAKSSKAHLLALPRDATVAELEAAVRQALGISAAKVTLAVEGCTPAATAAVGDVADACKHADGFLYVSVRGEQAMGALLAVFAGPCFASDSGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A606</accession>
    <name>A0AC62A606_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">P-type H+-ATPase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1820110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="XUY37121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="972" mass="106675" checksum="E1877E33A602F084" modified="2026-01-28" version="1">MGLNGSEKDAAAFEENPTSPLDAEMPPQKPQRRQSVLSKAVSEHDVNATGPMGDLLPPSKGLTTEEAEELLAKYGRNELPEKRTPSWLIYVRGLWGPMPAALWIAIIIEFALENWPDGAILLAIQIANATIGWFETIKAGDAVAALKNSLKPTATVYRDSKWQQIDAALLVPGDLVKLASGSAVPADCSINEGVIDVDEAALTGESLPVTMGPEHMPKMGSNVVRGEVEGTVQYTGTLTFFGKTAALLQSVESDLGNIHVILARVMIALCAISFVLCMCCFIYLLARFYESFRRALQFAVVVLVVSIPIALEIVVTTTLAVGSKHLSKHKIIVTKLSAIEMMSGVNMLCSDKTGTLTLNKMEIQEQCFTFEEGSDLHSTLVLAALAAKWREPPRDALDTMVLGAADLDECDNYEQLSFLPFDPTTKRTAATLVDRRTGEKFDVTKGAPHVILQMVYNQDEINDEVVDIIDSLAARGVRCLSVAKTDQQGRWHMAGILTFLDPPRPDTKDTIRRSKEYGVDVKMITGDHLLIAKEMCRMLNLDPNILTADKLPQIKDANDLPADLGEKYGDMMLSVGGFAQVFPEHKFMIVETLRQRGFTCAMTGDGVNDAPALKRADVGIAVHGATDAARAAADMVLTEPGLSVVVEAMLVSREVFQRMLSFLTYRISATLQLVCFFFIACFSLTPKSYGSMDPHFQFFHLPVLMFMLITLLNDGCLMTIGYDHVVPSERPQKWNLPVVFVSASILAAVACGSSLMLLWIGLEAYSSLYYPNSWFRHLGLAQLPQGKLVTMMYLKISISDFLTLFSSRTGGHFFFYMAPSPILLCGALISLFVSTMAASFWHKSSPDGVLTEGLAWGQTNSERLLPLWVWIYCIVWWFVQDIVKVLAHICMHAVDLFGCVSDTEGSGAVKPYSDGVEENGFAPKKRATEKAEKEFTSTPSSVADEVLEGLEEETHSPMEEMSHVSVHPPHGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6B9</accession>
    <name>A0AC62A6B9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amastin-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0820170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="XUY37297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="198" mass="21813" checksum="ADA6DF1D137B8C3B" modified="2026-01-28" version="1">MELTLALLLYAVLQLIAFLFVLVGTPIDMFRSRDEAPFGNTPCITLWGIKDKCYSGMLSQNSDDLWSSCPGRGSRFRVAQAFAIISIFVYGIAAALGFMLCCCSSLRWVCLALNLTGVITLCVVWASMMRTYYALDGRCFGQRFSYNFGSGFVLLVFAWCLNIIDMVFLLLPSQAKDPSDIGEPIKSAAASESNNAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6E2</accession>
    <name>A0AC62A6E2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tuzin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2020100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="596" mass="65700" checksum="AC8AD11C5C5D5F98" modified="2026-01-28" version="1">MLGPATRCCLLPAVRRSAFAQPGLEGLRIAAYAPAEPGVPPSPRRLPVAVGRVVAQLSPLVFAVDFRDSPPPPAVSLGSRVYVAYEREGAAPLPQQGGGVVDDAPGRGFLMGGFVVRVNPNGTLGVLLENNRVDLGVPPERIAVTEGVCKFVRHPGYLQVAEWVRSAGLSGADEVEGTACMLYHRGWRAERLHLLEASDTHCMTHLSQRSRMSLMEKAEWQRDHHRQMRSLSSERVKERDRRYMAAKYAGILSASVAFCGALSLFGWNYRNHLTHQRTSQMRFAVRTLCKEAPPGASTTADAAHQLSRQTRREALERWIRPVFQQLDTAHPRIAVITGSFGCGKSSLCRAAMREDGMAGVVVDVRVREDPLRRVVMTLGVPHVEACGDALDFISEACCRAKSMMGGKTPVIVLRLREADSLARVYNEALALACERRVCHVVVEVPLEALTVTSTLLPRLDFYTVPNFSRSQAHEYIQHRLDALDTVAFLDTVGTSRADLDELLAAAHQRRVSPAEYTSERLLRAMRQLQAAWGDDAQLKTAVKRLAQRPYGEGRHVGLDGSSLSHPSLRDVVLYNPVQDAWHFRSRVLHTAAACLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHE1</accession>
    <name>A0A088RHE1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Heat shock protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_040730</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="AIN95397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703719.1">
        <property type="nucleotide sequence ID" value="XM_010705417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHE1"/>
    <dbReference type="GeneID" id="22572032"/>
    <dbReference type="KEGG" id="lpan:LPMP_040730"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040013500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_040730"/>
    <dbReference type="eggNOG" id="KOG0714">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051434">
        <property type="entry name" value="DnaJ_C_subfamily_member5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019396">
        <property type="entry name" value="TM_Fragile-X-F-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44027">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44027:SF7">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10269">
        <property type="entry name" value="Tmemb_185A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0346">Stress response</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="462"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="9"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="380"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="511"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="586"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN95397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="596" mass="63706" checksum="1F12CC57208B1EB6" modified="2014-11-26" version="1">MFPRRCSGELYEVLGLHAQCTTAEISQQYRRLALRYHPDRNAGATVAQFQRIEEAHRVLSDLRQRQLYDTVGREGLKQLGDYGGGMLGSLLLAVGNVAAGCLLLGFMTAALFISLLISCYKIDAPEEWPSWGVVLIPVWCFLPVLLLASLTVMVASVRRGMYILLLPSVRLLLCIVIAATTAAALDHRITPLIAFIPWVIWYVLGTASDLAILVPTVYTRTHSPPFSEEEAAGGSGNQCTNARVEDPFLPPGGGYDRAGSVADSETTRSSGAEGGLGNDFSRPWKTARYWREVAEVLFEAVCVYTFLALAFQRAMQQEARLGRWGTPPQREGISGIDPVPPVLSFWVILSPLLVYFGAHVLISVAEVYFMGSTVITTPSFPEETPVTEGRSANMAASSSSHQQQQQQGESRRCVGCRECVANVIIRAFPSACGLYMACLWAAKEEYEYNKRTSGPDPSAFLAFLPILVILGAMSFLVCCGGCAVMCIGAAAFTAENTADASVPATARSTSANLFGSSGTAPPDGGGGGGARGAATSSGRESGYRSTASRAPPTLTATGDRGHTHARPSQHAGGTGVNRMAISQGRNTKDVTVEQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RI32</accession>
    <name>A0A088RI32_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Paraflagellar rod component par4, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_050040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="AIN95445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703767.1">
        <property type="nucleotide sequence ID" value="XM_010705465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RI32"/>
    <dbReference type="GeneID" id="22572082"/>
    <dbReference type="KEGG" id="lpan:LPMP_050040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_050005400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_050040"/>
    <dbReference type="eggNOG" id="ENOG502RFWD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="250119at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="252"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="398"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="581" mass="68218" checksum="60B2F70B0601777C" modified="2014-11-26" version="1">MVGKKGKGKKATLAKAKAEEQRLIQLRALEAEAEEFQRFENERRQHDEQEERIAFLRDEQLRIMLEKDRRIEDVMQQLTRVTAAMQDDKTGYETQIHQLSMLRDALLNEESLLKVEMEELHEILQQERVSNATYVQQLRDTLESERSLHQEEKKNLRSQVCEATASMEHTKRQLQLSCESHESAEHEFKVKVRDLERELEKALTMNKALQDAVEGREIEDRKNVTLLQLLNAQLESDKRRYEVDLCEERDRTTHARGEASHLEAKLREAQRELDIVREEARKARVSCEDELREYKQLTEQVKFDAEYLHREMESMRAEHAAAAEKSEAAQAAMQAELQQCQVELEASQKKNSEVGSLLLRKEREHFDKVTFLNAQVANGRTAIARLQEKMERERTAHGDELQQHNDTIQQTMQELERVSNAESVQLRERHMYEQRLITDMDGLKATIRELRTRVMEQDDAYEQLRELKESEIERLRCILDAHFIPNRQDVEVSRASSRADELFLVSEELRSVKKEMALKETAAKETERWLRARIAEQVEVIDSLQLDLKRTELGRNESICTLKDEVRRLRKTLEVHCIPCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RI46</accession>
    <name>A0A088RI46_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_060070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_010705588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RI46"/>
    <dbReference type="GeneID" id="22572213"/>
    <dbReference type="KEGG" id="lpan:LPMP_060070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060005800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_060070"/>
    <dbReference type="eggNOG" id="ENOG502S228">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="262959at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN95568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="448" mass="49386" checksum="3489BA70D8D2F677" modified="2014-11-26" version="1">MTLIHNDVLVVAGVSVCNVSWFIVEAHSLLLASATADAARISQQEQRRQQQQQSHGDGMWTEDEGVQLDFVFYDAKVSAMNDKSEVIDYTFLTAQPRPLQVPGEALAAYQARLKRWMEACYASYYAAHFIAHLRSASPALFLEYDSVSKLIGTADGQRPVHGLVAPTVDVSGDHLISFTIPLLLTKHSLKVFQSLSNLAVLYCKVSHAKWRPSYQLTGVEVDVHACFRTAQRTGRITLIAESVVLRLRDAAVAGEADAKTEGNATDSLIPLLHSCVNLQGLPRLTMAHQRAGFLDYIPRLEQALYRRIREPLHFMKLVLGLMADFGSPIDVSVSCRELTVPGDGTTLPPPPSPPMPRTAMFCAVDRTTKLSFTIGLHYQSAYDLPSVETTCNQYLDARHGAAVSRRVRFLKSPSSMRTDDDGFLDIEDLRVTVVHATLECMSASVALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RI60</accession>
    <name>A0A088RI60_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_060220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703905.1">
        <property type="nucleotide sequence ID" value="XM_010705603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RI60"/>
    <dbReference type="GeneID" id="22572228"/>
    <dbReference type="KEGG" id="lpan:LPMP_060220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060007700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_060220"/>
    <dbReference type="eggNOG" id="ENOG502QWRC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273037at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="647"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="712"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="750"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="647"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="657"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="721"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="750"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="763"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="838" mass="88804" checksum="56F06B91698E3E5B" modified="2014-11-26" version="1">MHVKRHNAKLMEWYDAQLGIQLPFSPVFFELKQEERQAPLILLTFRTVREPTHRMAVTIEELYEPQTAAAYSEASLGRIADCAKILGQTTTRIGSKDYPAAEYCYVDEHQSMSCVFSIFVVYKRLAVTVQYVAPARVRSVMPTTVYDIVRFLSFATSSPSPSYLLISEPRLGLGYHLPLDFLVHEGLAESDGVEDRLFTSPMTTGGGFLSISPDSINAPQQHTRGAAGAGGAAYLPYHRSSSYVGHSGGGDGSAWMAPYATAMSHGGRRIGLITSYEPTDVATGATSLGGGGGGAAAATGGNGVPYAWRPYLEQQVCKAVRQLGLVLDNSDNNCAPHVVFQAPVAAHPPSRPTLLVEPYPLSIALNGNFSASDDVREEDSDAVALVTAFSLFREVRVDVNSAYLTLVPDALESAAAAAGLPSSTGVADTTAGTAKAYWSAFYVPVGTACVSFHFIASALRHPSTEFVSFCATVMNSVSLGNHYGQSVSVLYCNTRHDVLPFCLSLPPTGMATVEEPMLADPLCVVQATYGVEKVGVTVRVFPLFTSTTSSAGDGSSGGGGGGAVVMAATDSQPPTPSKALPLRPIAARRGNRQGSTFRQLQCMIRYYLSQFPGGVHIVSHERTTINAMPAIRVCFKPLWYAGGIEEGGTQHTGGGSATAVPTTSSVTSWDEIGGGGGGSSHATSDWVEVRDALLEEAIGQLNPFAQYFPPPPPPASYLWGQQQHPQHASPSSGTTEKVSTLVTAASLRKATATGAAASGGAEARTRDDHESHPFYEPRGDESQHSQGELEDPLRVAIAVCCEGNAFLFQASASEYTLGMSMQAVQTLATHLTPIPRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIC9</accession>
    <name>A0A088RIC9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_051140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="AIN95555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703877.1">
        <property type="nucleotide sequence ID" value="XM_010705575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIC9"/>
    <dbReference type="GeneID" id="22572192"/>
    <dbReference type="KEGG" id="lpan:LPMP_051140"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_050015700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_051140"/>
    <dbReference type="eggNOG" id="ENOG502SMB4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266138at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="250"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="590"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="845"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN95555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="870" mass="92458" checksum="10393A6C2211B719" modified="2014-11-26" version="1">MSVSLERRQIYELGEVHPRSYGLKATEISSTMKLDLSHNHLRTLQRPFARSSLGGVRVAADAGAAVSSPSTATSVSASPMSLGEESSALRPFTSLAHLLVNHNQLRSLVGLCGVADTLTVLIATHNALTSLDGMQACRRLMYVDLSYNSIESLQGLPLILAAPSQRDASPSSVNAHDVQHRVVSVESMPALSHRGTSAVEGAAAAAQLFADVAALNDDEEITLERVDSSDNEGHAPISVSFLTSLEAETHRHSNVPSSAGHPHHHYHTRHSHQQQPPLSWSPGGIGSNRPGVVLILSHNRLRGRALPDILWVELAGAEMGTTFGATPLSAHVLLRPWCTALTHLDLSHNYIEDVRYVRRLFTPIRWPSSAASATCAPALTRLRRLDISGNPLLVNGSLAEELTRSVQSPPPATTASPWALLVSSPANARRPTIAPANDRQNNAERAPQASVEAIVADGYKSVLPPVHFRLNYASRTLDAALQAPSPSASAVAFPSLAAAQGAMDALLTSLAERWQCAAPSSSAPATETMFSLFSPSDTCTVEKASQPCAVHLRGGELTVFAAALQQRGARLGEMLEVPAPALCAKRAAESSTPHRACSARSPPSSGHARNGGAAHTDTAMAAGADASHAIFLTPPPRWSRGTSVNVDTSVLSGRGGASLTAAQRPTALTTLNFAPPTSRRAALVEAAQDEENMPDDAVSTITTNSSSHVETSTVGYRLYQGRGHQRQPGPVAVKSAERSGNAVAYRDATIDSGAAAVSCTSMLSCSADAVALQLLRAEVVELRRRYRELQRQTRDQTCVLQRQEATIRELKVRAAVTQREHQESKAGLSKAHLEIRRLREQVQALRTSATQTAPPPSTSVSLQLPLSDCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RII4</accession>
    <name>A0A088RII4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Condensin complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_060460</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CND2 (condensin subunit 2) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703927.1">
        <property type="nucleotide sequence ID" value="XM_010705625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RII4"/>
    <dbReference type="GeneID" id="22572252"/>
    <dbReference type="KEGG" id="lpan:LPMP_060460"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060010300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_060460"/>
    <dbReference type="eggNOG" id="KOG2328">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="362021at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022816">
        <property type="entry name" value="Condensin_barren_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108:SF9">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05786">
        <property type="entry name" value="Cnd2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="182"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="303"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="435"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="602"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="787"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="859"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="997"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="618"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="792"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="859"/>
            <end position="875"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN95605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1149" mass="120077" checksum="DFB6948DBCD415E8" modified="2014-11-26" version="1">MHTPEPRLRHSGGGVASPTPHVSSSNATPTPRAGFLRRGGSDMLHDAIAAGPSVLFDEETGTAVAVCASPQLSQLTQKQQLYAGQTRLPRQRPRFHTVQDLDVALNQAIEGKITSRNAWASKEASDLLEGITHTIETTLDAASTDDYSGFAKAATVVEGCSKVWTSRVDSTYQRSNQMVQRLLRKDDASGKPPTGDGDDGEEEDGEEGDVQRRPKSRSRSVAAASASAAATRTLAMEATEINLDSKSRTALTQTGVNAQFRAITSKFDQGNAQGLLMNNAPMGRAGNIILDVDYSVMPISAAVSGGSRQGSHRILGTNAPPPSRGSGAEGQENQGEPVAPSRVSQHAAVELDTAVYETVTDLPPYRGMMAAVSPTDQLRSARDSESFPQTCDSTGDARGSQASAIDPLLLLPHVSPRKQEVSDFARLSLKSNTCEGYNSSGTAAEGTSEGRSRITSHSDWTVPATAGGDAVKSPYDSQQEQEVEGEFATRGSGDNNGADGDDTDFGDWGGAGDDDDGSGYNNMADISARTGSDGADRGAEARRLVSGTAEMELIDTLFHGHTQLALEAEDPTSWCPLSEVSANPLVGVQGLSELSRLHREHRFAQSQKGTGSDDAARNWNSGERGSNLSSSVGLQLEPPSKRGRRERTVVFQLPQSPSCGQGAGTSGAASVTSTFATEAKVLLDDSALRQATTAARNITPLGKQLLLAKNAAQEVLAYTQSAVQRTKAEQAGLVLPEAPIPGKTIPSYMPFPVHTQDYFQPFCTSLAHWNLLRKSATGHLLDSAARARNNEGPSSSSVMAGSSHSGITGDCSSHSGPARRTGGYFSTEALDEDACGGVGVRYGDDNMPVEFFPGGAEVEAQDGGEAGGDYADYAELYGPDDDHSDEEERRYVQGGIRSSADASLIGEIELAAVAAAATTSATASGGSSMRGSGTGSDALLADPLELLKVLSPPEATIPNQVDVVKLRQLMWEALQGHLAANQVEKAVDLETLRTGAAAGTSQTAEEDGGGDTSSRTNRKGAVVKAHAQAALSMIRKRARTADGGEGAQSAACSKNTVADPFFHTESTVTGVAAAAAAAATPAGVAPARFSDIVRSVLPHISAVSSTNTLSPAFFFFSILFLANEHNVVLQSVESLDDLVACGIVGRVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIT1</accession>
    <name>A0A088RIT1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Qc-SNARE protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_080030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="AIN95813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704135.1">
        <property type="nucleotide sequence ID" value="XM_010705833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIT1"/>
    <dbReference type="GeneID" id="22572465"/>
    <dbReference type="KEGG" id="lpan:LPMP_080030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_080005200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_080030"/>
    <dbReference type="eggNOG" id="KOG0859">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="248747at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15843">
        <property type="entry name" value="R-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000098">
        <property type="entry name" value="Vesicle-associated membrane protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.50:FF:000022">
        <property type="entry name" value="Vesicle-associated membrane protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051097">
        <property type="entry name" value="Synaptobrevin-like_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136:SF174">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136">
        <property type="entry name" value="SNARE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="4">
        <location>
            <begin position="123"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN95813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="215" mass="24238" checksum="9618FB78A9F95BD3" modified="2014-11-26" version="1">MPIKYSCVNDEMRLLAEHPAGEQSKLAETMQKVIATVPPKEYRHKTIEDKDGGVNYNYISNGEGCIVACVTTSDMRMRTVFAFLEAVEPLVRGNVGSQGSELRNGKKLLQQKMEFYNNPQNDKITALNDDINQVVDVMIDNMDKVLARGDRIDTLHEKSSTLADQAQQFQRRSTELKRNLCMKNLKLTLMIAGAVIVMLIIIVLIACKPNFSRCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIZ3</accession>
    <name>A0A088RIZ3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">CLC-type chloride channel, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_010180</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009370">
        <property type="protein sequence ID" value="AIN95119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696661.1">
        <property type="nucleotide sequence ID" value="XM_010698359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIZ3"/>
    <dbReference type="GeneID" id="22571747"/>
    <dbReference type="KEGG" id="lpan:LPMP_010180"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_010006200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_010180"/>
    <dbReference type="eggNOG" id="KOG0475">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="44789at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000029">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF6">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0868">Chloride</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="431"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="490"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="717"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN95119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="768" mass="84219" checksum="ACC8CF7792B23564" modified="2014-11-26" version="1">MTQAGGGCGGTGVGGDDEAITRLVVNVPEADWATIDCFSSYTEAAERAAMRRRHTIPSTTHSPYGEKRPAYSFQGEAFLAALACGIALGCLGVISDACARWVSAFRSGICANFFWLDRSLCCVDGNECDEYYSWGEFFLGRDNHVVAFVDFVMYVGFSTLAAVTAAYLCKTYAPYASGGGIAEVKTIVSGYHVKRYLGGWTLITKVVAMCFSTGSGLTVGKEGPFVHIGACVGGIISGAFPSYQQETKERELITAGAGGGMAVAFGAPVGGVIFALEDVSTSYNFKALMAALICGVTAVLLQSRVDLWHTGCIVQFSINYRHNWHFFELPMFAVIGCFGGFMGSTFSVINLHICRWRKKHVKQWRLAEVTVVAAITGVVNFLTPYSSGGMLELLGDCFQDCTPDSSIEMCEGSDVRAFFSLLVTATAKFAMFTYTVGTFLPAGILVPSLTIGALYGRAFGMMFRSLQETYAGSYIFTECYHQDLCVIPGVYAIVGAAAMLTGVTHMTICLAIIMFELTGSLEYMVPIIVGILCAKAAGEAVGVKGTYEIVIEENKLPYLDPKKEFYLDFSAKDVYKNKQFTVLTAYGLQVRDINELVTRMNVTGFPVVESASDTTLLGYAPTKKMMRAIQVAAVRNRDVSLSTYTRFKTAPSHSQDPNFLEVNLTNVLESCLLQVEPECSVKKLLYLFKSLGTHHIVVCRYAKFEGFISKKDFINFMRVKEREENMEDDELERERRELARQRRRREVATAVIDRTTTTSAVRATAHHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJ65</accession>
    <name>A0A088RJ65_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SKP1 component dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_091170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN96032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704354.1">
        <property type="nucleotide sequence ID" value="XM_010706052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJ65"/>
    <dbReference type="GeneID" id="22572687"/>
    <dbReference type="KEGG" id="lpan:LPMP_091170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090017200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_091170"/>
    <dbReference type="eggNOG" id="ENOG502S62S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271800at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN96032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="22329" checksum="1626F72677B88343" modified="2014-11-26" version="1">MSNEEVFRITNVSGYSVEIPLATAKELLGMLDMDQVFRAARAGADDTDESADADDYDAEPLKAEGMEYSKEVLDVVRSYALLPSDERTNNIPRPLTQDLRSVVHAGEMELVEKAEREDYLVDLLNCALFLRFSQLSALCAAYIAVRIDEIAKAAPDIMEGAERIRKFLHMQNEWTEEEMGHLRREMEYAKSVDPNVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJ95</accession>
    <name>A0A088RJ95_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNaJ chaperone family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_080660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
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    </reference>
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        <property type="protein sequence ID" value="AIN95875.1"/>
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    <dbReference type="GeneID" id="22572528"/>
    <dbReference type="KEGG" id="lpan:LPMP_080660"/>
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    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_080660"/>
    <dbReference type="eggNOG" id="KOG0712">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DnaJ_C/III_chloroplastic"/>
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    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45090">
        <property type="entry name" value="CHAPERONE PROTEIN DNAJ 20 CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45090:SF4">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNAJ_2"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="3"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="276"/>
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            <begin position="247"/>
            <end position="274"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="302" mass="32975" checksum="3EB9CE147BA8B277" modified="2014-11-26" version="1">MQTLYDILNVPMGASQNELQHAYRRLFTRYHPDRCYHDNDSVAYNTNRKLDKERMSLLQKAYKVLANPQKRTEYDAHLAQKLASDSATYHLVPQQVRRLQGMTQPQVFAFGGGAIRSVSGIAGDVKAMEMPTVNGSSVSATAGVASAARQLTSTQEGACRGGAVHLQYANPMTRALATPFSVAEKSATTVQEEGVDFAKSPLTHTLSYVPVVYTASVSMRRCSDDTLPVPTMEEGSFKVDLAVPTDNTAAPDAQTSTAWPQVSQQHQEQPSAASPTAVPFALSDVQLPRRIRIIEEHLVILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJP1</accession>
    <name>A0A088RJP1_LEIPA</name>
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        <recommendedName>
            <fullName evidence="2">WASH1 WAHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_040700</name>
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    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AIN95394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_010705414.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A088RJP1"/>
    <dbReference type="GeneID" id="22572029"/>
    <dbReference type="KEGG" id="lpan:LPMP_040700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040015700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_040700"/>
    <dbReference type="eggNOG" id="ENOG502QSX3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021854">
        <property type="entry name" value="WASH1_WAHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11945">
        <property type="entry name" value="WASH_WAHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WASH1 WAHD" evidence="2">
        <location>
            <begin position="74"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="583"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="708"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="736"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="747"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="770"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF11945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="816" mass="84938" checksum="D70B672B3A8AC772" modified="2014-11-26" version="1">MATLAAAVVATSEVMDSGNSDDAQTSSSLNSRSSSVDSARAVAAARAYDTAAIAIIPGLVVPLTSASSQGGCAALASAVASLQALADTVGIVLDRLDRAAASQQRRLNAVQGRICTCAGFVDRLRGRRTATLLESKPRYPQPVPLKSRGGGRAKAAKSKWDAQGNANDAAAAAAAILSGVPSALSTAHSHRFLRPRRSSPLPPVAPSSCSESSTDDSGDDASQQPHPPSYQAPMRTVPAVPALTAPERATATAHHVLVRRGDSVSDFSRPLPPVNPVAAMRLAESMPLETVLLEGEDSNAVLVGNGGRGEATTGHVNERSMLTNAASSLPASSSSALAWQPRSLPVMRNGQTMHNAGEMPRTLSALVSFPAHQMAYRHLAAANSSCSSNVGSAIASVQHGALLHSDAYSPARRTTTAWLHSASMVEIELDFTTPLQAQQYAFVPGGDAAAASSRALLRDMPRNLPLQHLATVRRWDHGGGDQKPLIGGSTGSEDDVDEGVEEHEDDSSPRWQRRTSRRDPRDLETIAPSQQQRQRRAHRRHTLGDDGTVSEGSDDTAEGVTSARHRGRESGRARPKQQQTCETSTQPTAAAPSTLPPAPLLQAPPPPPGVTRSTTAPPPPPLPQAALLQGKANPPMFPLGSGGGAPQRLPPPPPPNFSAELRSAVGSRPPPPVTQVKMAPPPPPPTLSQLPVGVKPDGGRPVVSPPVQRVPPPPPPPPPLPSSQKPAVSALTSMLGERRRVLHGDDSSSTGSDSGFSNKNTAAHGKQADSPDSLSSSTSPRANPTVRGRLVNSAVQRLPPPPQLASSSSSDDESDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RK08</accession>
    <name>A0A088RK08_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_050670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="AIN95509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703831.1">
        <property type="nucleotide sequence ID" value="XM_010705529.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22572145"/>
    <dbReference type="KEGG" id="lpan:LPMP_050670"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_050011300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_050670"/>
    <dbReference type="eggNOG" id="ENOG502QSJK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="406368at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051291">
        <property type="entry name" value="CIMAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010736">
        <property type="entry name" value="SHIPPO-rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21580:SF28">
        <property type="entry name" value="BOREALIN N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21580">
        <property type="entry name" value="SHIPPO-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07004">
        <property type="entry name" value="SHIPPO-rpt"/>
        <property type="match status" value="19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="623"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1593"/>
            <end position="1612"/>
        </location>
    </feature>
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        <location>
            <begin position="1731"/>
            <end position="1762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2829"/>
            <end position="2849"/>
        </location>
    </feature>
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        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="411"/>
            <end position="423"/>
        </location>
    </feature>
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        <location>
            <begin position="432"/>
            <end position="448"/>
        </location>
    </feature>
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        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="563"/>
        </location>
    </feature>
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        <location>
            <begin position="589"/>
            <end position="598"/>
        </location>
    </feature>
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        <location>
            <begin position="708"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1747"/>
            <end position="1759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2849" mass="289862" checksum="B384ABCD3DA47DD0" modified="2014-11-26" version="1">MPSSSSYAAYLHEVALEMNATVSPGAITMCPTTDATEVIAARTTVAVPPSRLLRHRHQQGYDANHGHTNSSATTSCCSDQHTTESYEGSYAYDYLQVPAVGCLSRSNAVLLYEGWKQQQQRRVQAHMQRSSHSTRGVAVHSSSAPYTTSHLTAGIATRENEHKVNVDAMQRSFQHLYAVMKNEGRRQLHGTAETGRAAHLSHSISCSPHRQSRKSSTRSRRCHPDTASQQTQHGASTAIYIPSIDFDSDDIIIEDVSRHRSGMKTVQAAKEAMRAEKCVEISKSPQPAAGSTAISVKVVSPAPTSTDTSVITSSPSKPSTSSSRSCSPPRQSRGQRNQCPRCCRRCDLCHCVGLPRQVSVHARHSGGVVAVAGAARGESHPRSSSPAGGCWSTAAVDSVRLQWPGQSRTGSSRCPSPQQPSSPEARCSSTRSARHKSRQKSPAHGRHDRRYDRRVDRSRHGHHRETSSTAAAVLRDIATRTCTCYWAEFPGLTMAVNPVSHAAGCPYQAHEVLYTEVMLASKVDDGSSSSSSTSSRSRCSSSSSSDGRCDKSGRRSTSKHRRQERSTGTADASGRHDDARQRRTAQLRKTLDDPEAKRTRGRAAVMGSAKRRTYIEMMMDAARDSLPSASSRRPRSGGHGSTAKATASSFTTKKYLKATAAATPLLSSSMAQGRLPTGEAPPKLEDEQPQEQSPPPPSSRSASENDRAVAAAEAGEGATAVEKKHDKAGSSSREEKPPSASVGEAVGSTSYGNKPPAQETEKSPLPNEESPLRALSRPRCRPAVGVPGPGSYHVDLAYAASSAAHGIRGASIPKAPRMPAVKSTTPGPGAYDVYKREEEERKQLTAEVIAVRAAAATTTTDGDAAKGKETDATPAAGKPVIGKGIVFASTGARQLQLQYGDAYVHTSTWAKRAAAVPGPGAYNIVDGDHYDQSKPLGAARMGYHFSKSADGAHFCAAAAAATVAGGSAERQDGASSSPSPAPEKAGIRAAAELLRASFVVPWRDWAGGAYIGTTTSNFVAHPSLAGGDRRTLGQTVAADLTRVSCSKASAAVAAAEAAADGSVWKGVGSGVALRLTSQRFPVEVANAPATAVTATAVAKVQGSKTESNANAEGAAPPCGGPGPATYDLESALRWVHRRAPAVSMTFRHDRGPREPLCSVGGATDDGILSSAVGGGATLLSLSSSPHHLSDDAGLSPGPGTYDVRSGEAWRRRCSPQWSFGTAARHVSSAAVPVSAAGEGTNDLNSGNLGAVGHPGPGAYDTETGYRALQRSAASALMGTAARFTVDHSDRASAQASATEAGIADDGVRAGPSIYDVENCYAVLRERIKGGVIPRAGAAAWAKVGSEEAQCSGPGPGAYTLPALPPSGATAFLSTSAPRFPWEQTPAATVANGEGQGATVAAGAYPLHPSTDLFRANQVAPGPGSYDIDAATSLVNRPGAIIGRAPRASLLVPTGATSENVGPGSYMLPALPVGRGAVMLTARACAAAEAGDAAEQPGPGLYDPVDMRASSARAFSLARTSARFPDSDAHAADAPGPCAYGPPAAPVTRSAVFNTAPRFLPNSGDVADSLVGPGSYDPYRPNTAAPAHRIARARRFPDGDGDGDGTGADSVGPGAYEVVDLSPPGRSAVMGSAVARPTLEWKDGNSDGVTAVGSAAVGPGPGAYSPQYAQVERSAPRVVLARAPAGRGAVDYYASGDASMPFHAQHTGAGSGLGPGQYSPQYQTDLAQAGRGHTFGSAPRSAAAVESGVGGSGALDGPGPGAYEVRVTRDGRSVDGGDGSGAARFGTALRLAEEGTSATMSAGPGPGAYMPEAFTDMGAGGGNAALSSVVRFGTAPRILGGGDAGAAADVPGPGAYEPNPAMWWPTAPSISFPRANAAHALGGTDTPGPGAYITTTLAPPRAAHFGSAPRFEEGGTANAVSVPGPNAYSPNDAATLPAQSAHRFGAAARLTSVVEGAAEVDGVGPGAYDVETGLAYSSQGLTTAAYSFPRAGGSGSSRGQPSLGDKVAGGVAAFPGPGAYHLPPAFPEGPQWGFGTSMRSVAATGEAIVSSALATASPGPGEYAVPVPAPLHSGSSFPKAAIASPTGESISPGPGAYDVVDTAVRPSAPGVRFGSAVRHACADVSAVNLEAVAVGAHDEGAPWMPGPGAYSPNMNASSTLRSTRAGPTFAQAPRMAPSASVDAAGGRAGGEGSNIGPGAYDLQGGLSVSAAAAHRFGTAPRMPPTTASGAAAKSDVGPGSYEYPVTVQEHRRSALMLSRHNDLSGTTCNTPGPGAYDTTAALAAVQTSAAAYTFGTAPTQQRQSTETEMDALHTSPGPGSYDAASAYVSTQVARHPGGFTMQGRPVASMQVEPAEGPGPAAYAADTSAASVAPAHRFGTAPRMLSAPNGDAGVGPGTYDLPPLHATHQLVSFTQAPREVVIGPHDGGAGNLHSGDVRGGYVGGGTPGPGSYDVGSAIDSIQMGGRGPSITIPRGPRPVLRSGDVDASPLVGPGTYNPVYPTSHYHGGDSSGIHGPSAAFGLAERPVNVVKGSSDAPGPGTYDPHYPNLTNGVGIGSSFGSAARMDDVAAAALAATPGPGAYAVASSFHATSAAGSAPAVHFGTSKRPSAVLNENPGPGSYAVAHSNTAAAPSFGHTTRPDLLLNTNPGPGTYSLSPTWISGVGGATVGQSFGLSDRPTPVLNTNPGPGAYYRASNIDGASAAAGPSFGIGERMCVATGTATPGPGAYYKESLSAARGPSFGLAERPGPELNTNPGPGAYYRNSAASVAAGGAVGTSAGFGLGERHNPKLNDNPGPGTYFRGTLPAATQPRLRRPTAADTLRKLASVGYPTLASKTTPTTANTTTERHVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RK10</accession>
    <name>A0A088RK10_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_120190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009381">
        <property type="protein sequence ID" value="AIN96347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697000.1">
        <property type="nucleotide sequence ID" value="XM_010698698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RK10"/>
    <dbReference type="GeneID" id="22573025"/>
    <dbReference type="KEGG" id="lpan:LPMP_120190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_120006700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_120190"/>
    <dbReference type="eggNOG" id="ENOG502RYKM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273398at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="915" mass="98014" checksum="85FBDB78DBE22CE8" modified="2014-11-26" version="1">MSDVLGYLNGVLHRVSATFMPTEMDDVASFLRGDAWVVATAASASAPQATQSSSTAAIDLSREVSMPTSVRYPLGATRWGHFIPLGIAGTALVSAATSGSRTVLLNFFENRGFAQVFTVSLVPTEQQQQQQQSQLCPSMPGAMGGAGSSGGPAVSREGHRYAGLWRTQQAASSSSLSGAGDTTALRKRTRSNAASSAVVDISLDSRYSTTAEEARHVCMAAVRSWFEGVEEEALLDSSELRQSEDGHAADGAHYRHEIQLRRLLVIVRCCTDNRVAFSTCGGAAGAAQASSSGTGRRHRRGEDPLYLLLHELAALTTLYEVRLSATCSTVRPAVLLLPEDDSYGGSMLRQQLREEVGHRYWVELFPQPEGASSSSAARHGGTGTADAYRGARKGGGWKARLISCNSSASGAPGGSGSVLRQRQHEQTETPLTRAFRLAAQWGVLELPSAMSSEQMNVGGAVNTSSAGNSSPSMRVGSGGGGGGAAEQAPSSITSGLRGVRCMSTQQQEEELRRHTSCFFLRPSNAPLCVFLMEALRRFPVLVRPAVLQYWQSTWTARHSLADVLFAFHTVLCPFVMSASSAEVTGHSEAPLGTKGSPSFPASAMLQDTTDLLDALLSVALTLAEERDAAQPLSVNELTIEQATLFLLFYEALVHQRVGRLRRIPGVVRVLIDLSDRHASATAESGVSDASAAGVPCAGATTDAKVRWAVHHLLPFAPLNRFSERVAQLTAASHTRRDGRREVLPYPMDPIALPIRRLSLAPQLQHSTLLALMPLGESLLELQGAADRVWREELPAYWRRVVAAVSTRDDDTRVHSLPAALRVARDDAGTLAPTQLSATNFYHPLVPHAVRVLYVLTAHALRAPTEAAKQAPIVQLQLICQLSDEQLLLVLKELQVAGLASTNLKTKTARTLLDTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKC3</accession>
    <name>A0A088RKC3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">U-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_060500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703931.1">
        <property type="nucleotide sequence ID" value="XM_010705629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKC3"/>
    <dbReference type="GeneID" id="22572256"/>
    <dbReference type="KEGG" id="lpan:LPMP_060500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060010700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_060500"/>
    <dbReference type="eggNOG" id="ENOG502RD0K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273087at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16655">
        <property type="entry name" value="RING-Ubox_WDSUB1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052085">
        <property type="entry name" value="WD-SAM-U-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46573">
        <property type="entry name" value="WD REPEAT, SAM AND U-BOX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46573:SF1">
        <property type="entry name" value="WD REPEAT, SAM AND U-BOX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U-box" evidence="2">
        <location>
            <begin position="581"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="660" mass="70766" checksum="D4B031119E57B808" modified="2014-11-26" version="1">MQPTNLPRVSRAVARLCAILGDELFPIVIWLAMFGAVRLAPALVLRLSMSFPQVMDVPRLLLWRRRRDVSGGATSSAVVSASISAAADAAAAHLAELIKSTPPGSSSNGIRLSGGGSSGAYDATLRASWQRFYHQSLEVLVSIVTYSRRLWTYLLFQRSQCTPLRDAAAAVQRGEGGRPAVVELLVRLVTSFTSTWVHASGNMLFDTIVTYLSTRIGSWGSGSVGGGNAIGGSGRRYSSLSSGWRDLLVASCVSTGLNFVLQTYWVEALTGIGELRALPLATTAGDALSPSFSERIQFMLSALSRLGSKESLYRLCCMALRLQPQSDQRSSAAEEGRAYSSPPSPSGRAALQPLTRAAPPPPSSLDSGTLRTPSQPARVYLCGGNAFVFALSGFRFAYYGDPQQFTTAASNCITDALDLVLRQARQRAAAQNGRVSEALLEGQVWRPPASSLSSSHDVVLAPAASLQLLPLYMANFAVGASVGLVWRERRHLAIVRRVPLLGKVVELLFPLPPPPLRLPEALQELSPERNVLLLHSDGRAEVSGDALQLAPALKADEPTATTMPDVSSAGGPPAPRVTRIVAAQDLFCPIKRTLMCDPVQTADGFTYDRDGIEEWLRGHNTAPLTNLYLGSAALRVNYRARQKISGLILQYTTAMGVVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKF6</accession>
    <name>A0A088RKF6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Sec61-like pretranslocation protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_111060</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696953.1">
        <property type="nucleotide sequence ID" value="XM_010698651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKF6"/>
    <dbReference type="GeneID" id="22572971"/>
    <dbReference type="KEGG" id="lpan:LPMP_111060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_110014400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_111060"/>
    <dbReference type="eggNOG" id="KOG1373">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="420669at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3370.10:FF:000009">
        <property type="entry name" value="Pretranslocation protein, alpha subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="entry name" value="SecY subunit domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019561">
        <property type="entry name" value="Translocon_Sec61/SecY_plug_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006341">
        <property type="entry name" value="PRK08568.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="SECY/SEC61-ALPHA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10559">
        <property type="entry name" value="Plug_translocon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="Preprotein translocase SecY subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="286"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Translocon Sec61/SecY plug" evidence="11">
        <location>
            <begin position="42"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN96300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="486" mass="53784" checksum="791D56E1FE5FC7FC" modified="2014-11-26" version="1">MAKQANWLMSLKPLLAVLPEIEKPQRVPGIKERIMWTAVALFVFLICCQVPVYGSRPGNASDPFYWMRIVLASNKGTLMELGISPIVSASLILELLAGVGILTYDPNNREERAVFEGFQKMMGLVITAVEAVAYVSSGMYGDPSRIGVAMCGMIILQLMVATMICILLDELLAKGWGIGSGTSLFISTNVCDTIIWKAFSPSTINTGRGAEFEGAIIAFFHLLVSRTDKVRALREAFYRPQLPNLTNIFSTIVVFVVVVFFQGFRVPLMTKSKYNGGDRQPYMIKLFYTSNMPIILQTSIVSNISFFSQILSRRFGNRNFLINLLGRWEERGYNGGGNGQLFPVGGLAYYLVPPATFYDLMADPIHAIFYVVFVLTSCAIFSRLWITISHTAPRDVAKQLASQGRWLVQARESEEDMARLLEKYIPVAASFGGLCVGALTIFADFLGAIGSGTGILLSVTMINQYYEILQQEAQDLGYGFLKQKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKY5</accession>
    <name>A0A088RKY5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_140560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697290.1">
        <property type="nucleotide sequence ID" value="XM_010698988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKY5"/>
    <dbReference type="GeneID" id="22573323"/>
    <dbReference type="KEGG" id="lpan:LPMP_140560"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140010800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_140560"/>
    <dbReference type="eggNOG" id="KOG0306">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="407922at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002401">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051570">
        <property type="entry name" value="TBC1_cilium_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN 3 WDR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25172">
        <property type="entry name" value="Beta-prop_WDR3_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="253"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="792"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="834"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="394"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="718"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="322"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="402"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="414"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="450"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="467"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN96637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1156" mass="125141" checksum="248D0BF1CB17718C" modified="2014-11-26" version="1">MVEKTYLRYAVGPQGGAVVSNASLAMDVAVVPSRYTAAATGRNACQRTSSFSRGGRDISSRSALAPVVTTSAAAVFVPSLEAVRVYSVRSGELLHTLIPAEVKMPVEVTTLRVVPMEANQRGGKLGADVDAHNGSGAASQQYSTGWLLFVGYSNGYVAVFSCSAANNYGLPVCRFYALGHRVDTQVLAVAVDSPRSMLCSAGQDTDITVWDLVSQEASFRLRGHRGGVVALAVVHPSSISTGTVGDMRSTAFDRTLLLSGSADGLVKTWDLILRQCLHTVIASDTQITAMMVDSQGRRLYCGLRENYLKVYNTEPLLAAAEQSGTTNARNGTSAETKLEDGAILDHGTVPRKYHKPITALDFSHDGAFIVGCTSRTVEVFHVLTAEDVKKKLYRKRKRRRGPGAAATATGMTTDGDDGAEGENEEADVGPKNNMGKKASRKRNKMGNTVGEDDGAEDGDDDDDGDHAGPSHGGTAARAATAVAATAAEEVVSLRAFFLPQKIRSVHFVPPTARDQLSEVDTLHIAVTYSSNTMETFTTTLTTSDREGASVLTLTDLKPRHTFDWKGHHNDIRELAFVDTDTALLSMSKEKVMMWSLTVKEDLLESDHLDNHDFYDAKEANLARVDFKGALNNVGSVDVEGASCMSAISSLLCCVGQQDGSVLLLDVASSALLFRDTAIHVGGVKHIVRKPDGAGFVTLGADRRILFWSIGLTEDKGVQNADSSGADRGEDDNAMTAGAGGSGATLVQEQEIELTEAPLCAAFSPDDRFFGVGLQNNNIQLFFADSMKPYLSLFGHKLPPTSLSFSTDGTLVASVGMDKSLRFWGTDFGDCHRAIHAHDDYITQVEFLQDTHYVFTVSMDGSVKQWDGDNWIMIQLFRQHQRGLWAVSVTANSTCVATAGADRCIRCFLRTQDIVFPHEEEARMAQEAMDEETAKRAALQRLDGGDANGTGTAEVGIAGQQTATTAEAAERLMEALDIVNVEQQRKQRGDDTTPRHPLLLNMSEWEFLWSTIETIRPSELRYTLLSLTSIHVDALLTALESMLTEKAVLNYEIASKVVLALVMIPAESASIQGLRAAAVRGEVSEVRGARRLAVLRRCISEGLDESVSRMDYSVAGLHLVRQHLEDTEKVKFFDCSKAQGYKRKYHSRALFTSEGKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RL61</accession>
    <name>A0A088RL61_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Potassium channel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_140520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697286.1">
        <property type="nucleotide sequence ID" value="XM_010698984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RL61"/>
    <dbReference type="GeneID" id="22573319"/>
    <dbReference type="KEGG" id="lpan:LPMP_140520"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140010400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_140520"/>
    <dbReference type="eggNOG" id="KOG3684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8879391at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016286">
        <property type="term" value="F:small conductance calcium-activated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015449">
        <property type="entry name" value="K_chnl_Ca-activ_SK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10153">
        <property type="entry name" value="SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="3">
        <location>
            <begin position="204"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN96633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="507" mass="56108" checksum="E10BD440D00B7D51" modified="2014-11-26" version="1">MELRARIEKLSRAQAPTAVPDASSPMTQRLVSLEHDQVNHRWLRGVMAFLAFLCCLISVFQVNGYAGNVVLHVLILALSLAGEVCIVFVYRIKTRFAGVTNPASHSVNPLHSPYLSRMLGEMLVWIIMAPPGVKSTATWAQVLDSFIVLRSYVYVLYFTRLSTQSVFKRAVASLCGYHFNSLYLLYYYTFMPRHAIVTGCGFMVAWLGLSLLYSKSEEVSYADGLYFCSSTMGFVGYSDVVPSMWMGRFTAFLAWCLGLLVIGWCISLMHALILVSPAEHNLHTLFRTNKLCAQVPGEAALTIQRAWKLYVAKREKRNQLSLHFNALLLSNQACRFRSLRREFVECEMTFIRATYTFDDSLTALSRLSSLRTTPAGTPCLSGSTTPTLTGGTPKSTTGRRSFSLFKEVKLKSPQGSSFPPSVNVEAGHADGRSPPLASLASPSSLPPLELRGFLSDQQFRHSSPAASSTGSDIATRLTRLDETLSMLIRKAERMAPRVLASSTEVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RL81</accession>
    <name>A0A088RL81_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="12">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_140670</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="12"/>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697301.1">
        <property type="nucleotide sequence ID" value="XM_010698999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RL81"/>
    <dbReference type="GeneID" id="22573334"/>
    <dbReference type="KEGG" id="lpan:LPMP_140670"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140011900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_140670"/>
    <dbReference type="eggNOG" id="KOG3072">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF161">
        <property type="entry name" value="ELONGATION OF FATTY ACIDS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIN96648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="294" mass="33021" checksum="62E175D6EC5E6B6B" modified="2014-11-26" version="1">MFPFEEYVSGRVVQQYMRDNVDYVCYLAFAYMGMVRYGPGIAKALLGDNPAPQPSANGKRAKPAADPEWLRLSMIVWNFLLAGFSICGAIVLVPALLSSIKDNGLKRSVCEYRDDLTYSTPRGFWFAMFVLSKIPELVDTLWLILQKKKTPPFLHWYHHVSVLIFSWFSYAAGNSTMSVFCTMNICVHSVMYMYFALCACGIKKVLRPFAPLITALQILQMVGGTALTFYSYAVNMSSYNAGIEDIHKLPCAVPKSAARFGALMYLSYLYLFCELYVNSYITGPSRATVAKKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLP0</accession>
    <name>A0A088RLP0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_151260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697501.1">
        <property type="nucleotide sequence ID" value="XM_010699199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLP0"/>
    <dbReference type="GeneID" id="22573546"/>
    <dbReference type="KEGG" id="lpan:LPMP_151260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150018100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_151260"/>
    <dbReference type="eggNOG" id="ENOG502S2UD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="444540at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051581">
        <property type="entry name" value="Ca-bind"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34524">
        <property type="entry name" value="CALCYPHOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34524:SF8">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN96848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="47121" checksum="500E0B6778A6A5FD" modified="2014-11-26" version="1">MVSLAYLGAFRSLPSVSLSLLLHRWMYSRMPMRAATYTVPRKSTAVSAPHPSPLFETGDRREETNQMASLNNNNIREDAVLKWRVKDVLLSHGGTGGLVNALVDFSSRAAVSVRQQSQIAATGASATCADVGLSYEQFLLFLQDHSVCLTPFEAAYLCRAFDDHRTGLVSAATFTRHLTGLSERRLRAVNKAWRSLEKRKGAGGGVSRERLLSTYAAVAAERAHPAASAVGGPADGTAHNAAAAVPLSSPLGSALESTFGGADGTRGHLKEAYMASMMSRSGGFMAKPNIAAGGADDVSGEVEDRISYAEFLAFYAGVSPQFATDEAFVTHVLQSWAADDATRPTLNETAREWGPDGDPLMLDGPRYVKDALNLELGMSSKSYNYSHMQREHPYVESLPPLNRPEIMATTVQRTHISFSKAAQALADPLVTRRGQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMC7</accession>
    <name>A0A088RMC7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein kinase, putative</fullName>
            <ecNumber evidence="9">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_170350</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="9"/>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697726.1">
        <property type="nucleotide sequence ID" value="XM_010699424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMC7"/>
    <dbReference type="GeneID" id="22573778"/>
    <dbReference type="KEGG" id="lpan:LPMP_170350"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170008800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_170350"/>
    <dbReference type="eggNOG" id="KOG0198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="262201at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584:SF369">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="858"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="475"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="786"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1100"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="786"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="804"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1102"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="887"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN97073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1166" mass="126946" checksum="9AD8D199DB20A3CA" modified="2014-11-26" version="1">MRQEKTMQDFSIPLKRSASSKGRMCHEHCRSGSIGSDTSVLSSEEADPSGVMQDLDAAAAVAVASTSDSNSLANCIYLDMNDKKLLASKLGGISETFDNSEEDLDGDTGTSASRTGGLSFERTITDLPSTISASTCAPRGKAVPLEVRRFQCTKSILAFKEATKNDATPVPPKLVDFIVSLTTSKNGLCTEKEMCDWMVAQMCDRLETGQMWVISKTSNLLFSLLWRGSHVFIESVHSNGKSLFQVSHLAEVIKRTPQENITGKRLPCSLQSIKQSVAGQRPACSRPKPNNIANSNGALNPATVCFLEQLKQKAMLNSVANLGPPPDNEPIPLHINPTFDIPERETGFFISNTAYMESLCEYRFRHPTLDLAHGEILCDADYCYGDGSADSASGVPTHRTHPAVWEELLNDTLELIKAIATTDPQISICPTGMALATTRLRNAVLLYQVACRSLVRLVHSIFTSLRKVVSPQQTGLAVPSTTERTRAEQHPHSISGGDKVNGGCPAAVNFTFSSETARGFVNMHYNAIYQFNRTVRMFKAYCEATQHVSAEVAKKAADALRLVPEDDFAAFREALNQLQRSECGKVIDQLHLVAQSSSQETNDGSVRAPSVHCTSTGRAVADRNSMSNVAVGRVSSASRTPLLDSSALSTSPLNEGVCGSLLTLYEFNVAYTEDRKPMWIRQVDAVCALFDDKESAILRQIFKDGVDELWGQLHQFTNNSMAAAERALMTSSESPMLAARRDSSSVPCLLSSDGGGLQSEGRHVSYGDMTTRSSTYILRSLPRDVQSSQMGRSGSSVGKRDIISLNSGRESNTASLTGTAKSTERSIEELLEEDDVVVICNEECSCNDTLKLIDRFQVLMDVPLGQGSYGKVFRAWDEVTGCYLAAKELSLDLSKAHNVAVREVLQEYTVLTELSHPNIVRVVAFMVMKKSARIYMEWIPSGSLQDVLRHHPRGALRENIVRRYARDVVTGLTYLHSRGIIHRDVKPANMLLSSDGTVKLTDFGTSLVLNGNNRTLESNAITGTAAYMAPECVQGTYSSASDIWSFGCSLVQLLTGNAPWYNAEAGSSPEPIALLFKIGCLNDTTHLERPHDVLMEAPAATPTPSEVSASPSAATGPNISSTTATAAQPLDTSEELINMLNSIFMADRKKRPSARDLLHHPFFKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMJ4</accession>
    <name>A0A088RMJ4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_170850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697776.1">
        <property type="nucleotide sequence ID" value="XM_010699474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMJ4"/>
    <dbReference type="GeneID" id="22573828"/>
    <dbReference type="KEGG" id="lpan:LPMP_170850"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170014300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_170850"/>
    <dbReference type="eggNOG" id="ENOG502SS9G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264113at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="132" mass="15332" checksum="1B8A7EBAD97890C1" modified="2014-11-26" version="1">MSFTTKFAMWWGSVTTKTENLFNKEKQRLVAHEYYDNPNPKSARPKSMHSIRGSMRAAGSTRSFQSADDTEKRSKSSHQQQERKYEGTVEQVSGYSNSQYSGAQQGQYMQDPQYMHQQQYQGYPNQGYNQAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RND1</accession>
    <name>A0A088RND1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_200800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698279.1">
        <property type="nucleotide sequence ID" value="XM_010699977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RND1"/>
    <dbReference type="GeneID" id="22574287"/>
    <dbReference type="KEGG" id="lpan:LPMP_200800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200012100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_200800"/>
    <dbReference type="eggNOG" id="ENOG502SIX8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273378at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="24721" checksum="A702C4A95B2693CB" modified="2014-11-26" version="1">MDTLTFRRANRYGDEANGAAYIESEYSYVSPSEQFAEDNLLRSYAGRYNSHHTARGDSVNCDLFSMQRVMDMTGSLQREQEDREAREAVVDISEAERMRQVRDAQWEAVKARMSQRATSMHTVRAHDSEDDEEEVELRSGHTTLSASLNALVPSLSEERAMQSGGSCVVESMPERFCHFVYNWFMYFVYALSVSAVPGIDARKGADSREYFDFRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNJ1</accession>
    <name>A0A088RNJ1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kinesin, putative</fullName>
            <ecNumber evidence="7">5.6.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_190670</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.3" evidence="7"/>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698063.1">
        <property type="nucleotide sequence ID" value="XM_010699761.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22574121"/>
    <dbReference type="KEGG" id="lpan:LPMP_190670"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190015700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_190670"/>
    <dbReference type="eggNOG" id="KOG0241">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0245">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267092at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000135">
        <property type="entry name" value="Putative kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="6">
        <location>
            <begin position="36"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="247"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="693"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1325"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1358"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1666"/>
            <end position="1722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2197"/>
            <end position="2238"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="864"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="958"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1221"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1893"/>
            <end position="1920"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="2012"/>
            <end position="2118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="693"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="716"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="726"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="749"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="785"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1326"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1365"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1377"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1691"/>
            <end position="1700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1701"/>
            <end position="1710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1711"/>
            <end position="1722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2209"/>
            <end position="2226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="173"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN97410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2312" mass="252551" checksum="3F8437607434CA4A" modified="2014-11-26" version="1">MSTRNNMDGESVSSTNTTASVSPALPKLPHGNESSPTKVFVRVRPFSAAERGKGDSEPTTIVTVSDENSSHITTLDPSKGYQPKTTYIFDRCFNSAAGAEADEAQRLLLGDAENGGKALASMTTLEGVGAEGAMNPILLDYLRRDQAAVYGHVGRPVLLNALAGYNGCVFAYGQTGSGKTYTMMGPPGTLGAAIMGAPAQSRAATGAPTKKFRRAATTYNNSLHWMPDVKADEAADSRFQSFASMTHRTGGHGEAMSVTGDGPSSLDDSMSAPSDVALQQSRHGGQHDSKALYMGSEEGLQGIVPRLVRDLFAELHQKREHDSSHSFRVEVEYYEIYREKVMDLLSSSSGGSGTSGVNSNGNVELRVRHSKSAGPYVENLTKKHVGDEGEVLRLLRHGNLRRRTATTTMNDRSSRSHAIFVLHIVQIRISDKDSSSAKVSSKVNLVDLAGSERTGAHSVEGDQFKEGVVINSSLTVLGRVIDALADKSSGKRNVFCPYRDSVLTWLLMDSLGGNSKTTMVATVSPHPSSFDESCQTLRYASRAKQIVTKVVVNEDPQVRQIRLLTTEVQRLKALLSAEGKSADNDDDVDALQERIDALEKELNETRNELEQKSSELAAICASRRTLSMVPSTLKASNAGAAGTAKELAKAKWDVRRLEAENLLHLQTEQELHTTMERLKALEKKYGQLLSDTKEAQEVAKKRDREKQEKDKLISELQHQLQQQTTRVQAKSLHTGSLYTGSPRPDSEKSAANVSALTTTGMEAVSPTVETNESGKVAGKKKKAKPGTAGSTTTPTNAAQPVSTPRRDSEWLMETERLRAQFEEDKKHLTLQLQERNNAFRLSQLEVKRLKSELKGEQDALYAVEKLLRDQHAEATRRLEEEVQEMKRALKEERRCSKDLRQSLAEPFGERPLFSCAYVAQTVFHDEEGRRSDVQQQEAVARQHVEQAWQLSQLEAAKVAAVERKYAAHLAELQRTAEQHRAHLEEVQAAHTALAEKHAALSEAHRASERTAEVIRQELEEKRAAQEEASHLHQVKASAQQEKANALRELISELEGAATLQAEKEQQLQGQLAYLEEQLCQEQERSKTALQRLEAEWKDQMHAVAAAEEAALRAEREEHATAVASLQAQIQQAEDRLHKSEEARRTQVMRGLEQAREHEAALAMLQSQLEESKKAATAADEVYQGEQAALRQKLIEQEVYASRALALEQELAAAHTQLDRDRRASAKAVSELEEQLTAAQAEHTASVEALQLNAERALAQVADHEKAVQLLRSDLETERAAAQTAAHEHAALSARLVEQLQEQRGQCEAISASLTEKVAELQTKLTVAEETHSTESKRAADAAKAQERALTDLRAELESTQTAHSNAEKMHEEKLREMQSTQARLTQKSQENADALAAQAAQLQARLAATERDSESTLRTLKEEMDTIRTQLQNSEEARRQQIQRSMDQALEHDAALAELRRQVAEEQAAKTAEANRHNEALLNAEKKFAAHQLEASETISGLKQQLEQAHHSAQLRQADATAAQQIVQRELDCTRAELEASEKARAAHIQRSVEKAAAQERTEAKLRAEISCLAARAETADAAHSAQVAELQEYLREQQGAAAAQLAEAAAALESERAKSQQASADHEKSLAAVLDQIASLEAALATSEVAQKAQAQRFMEQSAAHDSAIQAARHDLQRQQAEAADTAAAHAKELREWETKWQQQTASSNAEKESLRREADAQRRAEVDAAVKAHTATEEGLQATLSEVRIRLGEVEALRAAEAMQREQQSSEHAKVFSALQAELHSVHQASAAAAAAHMAAVEQLNSVIAEQKRVKTEEVTAIAEKLRETQRQLFSSEEARRRKVIEKAEAAAAHIMLFDALRRPMEAKHQQKLATLTAAKAAEVEAVQMELAAQRALTQQLQTNLQDARLQVRQMAETQNYVDKQMEVEKQANAELRQSLADTAAQQAASAAVAAGLEVTLEQTKESLAQLVAERTVLSTKLAKAIETVETTRVHLAAVEKIAQQRHEELEAQGAALAEASASVDQLRAEVSALRSQCAETEKVRDALIKQYEEALVAQQVDTVTELEEKFRAMEHEREMVVHKAQETEEALRSVIEKQEKKLKQLREDLEFGASLDQCEAEVVERDSAIGAAASSTGLTVAGSGTRIVSSNTSFSAPGSSAVPVGSGGGFGTMFSSFFSRRNTTAALPVSPAPYASGTGMDDANDLPQTLTRPFSGNNRSRATTPLRRSANGNLYSTSTHLHSSIMSPSLFFGKTNSAGSVAMVASSGAPSASRNAAQGAIEDPGVNEEASTLHARLGIRATNIVLGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNY7</accession>
    <name>A0A088RNY7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquitin-protein ligase, putative</fullName>
            <ecNumber evidence="4">6.3.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_203120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.2.-" evidence="4"/>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698514.1">
        <property type="nucleotide sequence ID" value="XM_010700212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNY7"/>
    <dbReference type="GeneID" id="22574523"/>
    <dbReference type="KEGG" id="lpan:LPMP_203120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200037100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_203120"/>
    <dbReference type="eggNOG" id="ENOG502SMRE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272252at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="3">
        <location>
            <begin position="38"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="237"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="257"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN97807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="323" mass="36477" checksum="D906BC84B788D0C4" modified="2014-11-26" version="1">MNEAAPFCVAPQTWQGGLARYPASQSHMWNNNIILQPEDIDVEVFTAICQVEKQYNKNEISDEDFETLQLTFCLFTVNQSCYDLIPNGREIRVTQANAFEFFQRVHAPYDNLKQAPTLNQPTESTSPPRLRMTGARLRLTAQNTDDLEWIRWTAQNDPAALAFHPDEPLRWAVVPRSRDFMIRVQPEGEKTFVGPDHLGLFLDTLAILLTEIERAISVFGYYPPNCIAAAPVMDHDKHSIHTSQPPRITHLPFPPQRVNSPRRSSLQRSTMSVSATAAAAAATMQNRRIIRRASSAELEKQRALFSPTHDTGGLLAPFQELNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RP42</accession>
    <name>A0A088RP42_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_201990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698400.1">
        <property type="nucleotide sequence ID" value="XM_010700098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RP42"/>
    <dbReference type="GeneID" id="22574408"/>
    <dbReference type="KEGG" id="lpan:LPMP_201990"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200025300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201990"/>
    <dbReference type="eggNOG" id="ENOG502SS4C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="238765at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="83" mass="9909" checksum="95D283350160B615" modified="2014-11-26" version="1">MFQRTTLCCYSALIGQATPVFLGSKGGTPKRKKNPMQLRRKTYGLHFKERYLKMEEWYYCPLCAEPKKQGEWCRREDCRQIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPA5</accession>
    <name>A0A088RPA5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_204380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698639.1">
        <property type="nucleotide sequence ID" value="XM_010700337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPA5"/>
    <dbReference type="GeneID" id="22574649"/>
    <dbReference type="KEGG" id="lpan:LPMP_204380"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200050600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_204380"/>
    <dbReference type="eggNOG" id="ENOG502RY56">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="41814" checksum="323AF3B16D679791" modified="2014-11-26" version="1">MEEDARLEATEPYIVAELQAEFVGHSLREVYTTICDRLRLTPLTSVAVMFPDVADAWDAVTMLDFSRTYVGSQGALPVIELCRRLPRLQSLTFYDNYLSNNTVWYLAQMALYHPGLERVDLSANEYISWSGAMCLVELVLRNPHIVYVGLRGSTVSAEIVASIEAQTRKNAVSRFRNEDLKRLPPVHPVAMYIRALKHQFAMHQQDGLVSASLLDSGFEELLRVSGRTGELHLFTDKYFSKLKARASPGSLTCEAFLLLLLIEGSTYDETTVEKLKHVFTMFNMDPSVPDPIKDGYVLGRDMADIMTHMYGSRPSDVDVAALQCRLGATAEATTLSWEEFLYIAYPHGPQVGDRLWGMMCTPLSNPIEIMHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPA6</accession>
    <name>A0A088RPA6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lipophosphoglycan biosynthetic protein (Lpg2)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LPG2</name>
        <name evidence="7" type="ORF">LPMP_202820</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698485.1">
        <property type="nucleotide sequence ID" value="XM_010700183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPA6"/>
    <dbReference type="GeneID" id="22574492"/>
    <dbReference type="KEGG" id="lpan:LPMP_202820"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000010300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_202820"/>
    <dbReference type="eggNOG" id="KOG1444">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="417037at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="17"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN97778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="347" mass="37875" checksum="1E80D575090A9D11" modified="2014-11-26" version="1">MTSVSPMNHSHIVMEAALSVMAYSFCSVSMILVNKLIMNTYDMNFPFGILLLQTGGALMIVTLAKATRFIDYSAFSLDVAKQWLPLTLLFVSMLSTSMKSLGSMSVAAQTIIKNLAVVFIALGDKFLYGKAQTPSVYVSFALMFFGSYLGAKGDKWVTPWGLFWTFLNIAATVLYTLYMKTMLGSVSNSIGRYGPVFYNNLLSLPFFLVMGVGEIMPFATAISETTSLGKLVLVFSVLVSSVMTFSVFWCMSITSPTTMSVIGSLNKIPLTFLGMLVFHQFPTATGYVGIVVALAAGFLYTHLNITANRAKSAADAENHRQQTRMNSSPFAVLAPEEEKNIDTVKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPB4</accession>
    <name>A0A088RPB4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_204490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698649.1">
        <property type="nucleotide sequence ID" value="XM_010700347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPB4"/>
    <dbReference type="GeneID" id="22574660"/>
    <dbReference type="KEGG" id="lpan:LPMP_204490"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200051600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_204490"/>
    <dbReference type="eggNOG" id="ENOG502SI65">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277389at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="261" mass="29022" checksum="13D589B451A5754D" modified="2014-11-26" version="1">MNRASKILWMATLSRAAAEDGQDSMRKLALLPLTFLSLSGNTSYLASILASAVGFLEGYSVSDLEADINFVKTPSGDFVAHTQLNLVPYTRWKAPTLVSSTPVVDTLPSTSTKTLVASHRLSISHVIADEVPHTFSAEEVSQLQRFKDSFKGSASAVDYVANDLLRTTDSVKVAKVVLRFSAQVGLTIPRSTLQELVQRLKPEEAFFASRICQEFAFEVNLERLHRSSLICSQRVLHLVDSPRRKREESKLERLRRTTSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPQ5</accession>
    <name>A0A088RPQ5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_203200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698522.1">
        <property type="nucleotide sequence ID" value="XM_010700220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPQ5"/>
    <dbReference type="GeneID" id="22574531"/>
    <dbReference type="KEGG" id="lpan:LPMP_203200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200038000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_203200"/>
    <dbReference type="eggNOG" id="KOG1840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="443949at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:002245">
        <property type="entry name" value="Tetratricopeptide repeat, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF19">
        <property type="entry name" value="NEPHROCYSTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="426" mass="46870" checksum="2DA80012B2045B38" modified="2014-11-26" version="1">MFARLALPKSRLVIAVTGSNSVSLYRGRLAVATAALGASSFTSAARASQRWSSSGVISNNSSSGASSAGTIATLDLSEKELIELNKKAAEAFEKGDFLSAIEAWEKVVQSKQHTPNSPTLMSCLNNLACAYGEMGDNVRKMKLLERSRDLVQTVYGTDHPQYGMVLYNMACAKEEMGLYVDMKRLLVKSLALHEKRFNPRHAKVGRVLLLLASAHGHLGEHEAQLQAAERAYEIVKRHCGPDHVQTTMAMITLGRAYGAAGQVERQLQLVQAAHSIQEKRLGPMNPQLAMTLLEVADAHRVNGDFYNQKALLEQAMELQQRSFGQQHAHLIDTYIALGDACGQLENPELQAQYYLEALRIARQRFQGRHIAIGKAAVNAARAYRSQGDNAKAQALLDEARFIVERNVSPEHPLSKQLDKVTRELAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQ59</accession>
    <name>A0A088RQ59_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Serine/threonine protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_210170</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698805.1">
        <property type="nucleotide sequence ID" value="XM_010700503.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22574839"/>
    <dbReference type="KEGG" id="lpan:LPMP_210170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210006400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_210170"/>
    <dbReference type="eggNOG" id="KOG0198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272748at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001153">
        <property type="entry name" value="Putative serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584:SF369">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="601"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1417"/>
            <end position="1674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="203"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1186"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1206"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1219"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="1446"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN98098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1676" mass="182919" checksum="B15CEA7908FA862C" modified="2014-11-26" version="1">MEEETPQNGGIQCVFTASSSASEEEATLSANVASSVDCCNDTLRIELPAISSGQCTGTGSPKSAICRPSEIAFSNKMEECTALSVEEHNAYQSAVALLQAGVLQKLVGGLGGQGVSRKLSSVIPTFSNFDPTEAIRTKSVSLFRNARQNNRGSLSISGGTLQCEMSIAADRLNDGETDGVILCSEAANHCSRHRESHPALRTVIAPGTSSPPPSPEQRQRCGPTSTSALDPSISLADGQSVEGNDSPDHGVAMDVVLRDASKIRGLRLTWLLYLLIITVIILFVLVLVQITYETSHMLTRSATEAVQAQAASLLNSVNMQQYTLEKLFKVMYEMNIKSFIQEYNTHSIVRDVMCSSLCHAPIAFASYNASGMQQWRVVCKPSMPSIELNLFPKKVMPGAASLLMVDYGKTALAYRTFYKNDNVETYVVITGKEALGRTFMNNNIAKYSTATLQSVVSAFFLQEWNTTRMSMLFHTLTENVSFYRNTPTSPTAEVLTSTFNSLCHADSPYVWHTVLRPMNQFNIAELPVNTPDQMGTMTNPIPTPLFEHKGAWGQVSRATLCSVTCTSANGSKCTPENPTNVWFLVDHSLAHLDSIQTTVKIVGVVSVMAVAIFSFIMFLVYISITVPVNHLRFQLMRAVGSNEMTTPWQRKIARWTYRLWLGDLTSIARSIYILSLCFRLNKKYVPDHVLRNHAKQLYLRRRKFNFLDEVNLKEDTVLEEDTDSDEANPSLVGVDTTLRPYDTLSLWHLAVPCGMDQVGHAATDGKVDCSAAEARIFGGPTLTEVSPGYASQPPLPAKSHETVTGGRVAPTRRGARLLRDASLNLGTYGEVEDMVMTQEALTVAASAMTIQSSNDIMNIRCEYETTVLCVRIPSVQLAYLINHSVAVHQHRRIMRVLLHRIRRHKGALFHCSGDCLGAVWNAFEGCPNHAECAAVCAQEIANVFAPYQSDGLHIGIVLHQGTLVCGTVEYSKTAFVTAFGDGPREALAVAELATSINSLNVLVTEPVKQALSGLYDCNIVDVIQLPSSAHQLLLFELSGSRTPERSLYDTLLQLPKQAQFSIDYARAFAQFRNHEFSEALQSIQKLQAHGSSRNTHLLRRLERLCLFYSAQPAALPRPYHRAFPVWVNYEAIAQAGLRNDPHFKTSQSECLMLHNTDRGVVYQGVPALRNDMDCIRDFKQELQENMRRLGSPRSTTRHRGSPAIDSSSTPPHSSPQPFLSMQSTPMPTSATAGMLSDASRHVSELLSATLPTKPRHVDPQENTAQMSLPSRLPAPAVAVAPHRSIAGTLLVAASAAAPMTCEEPKDRDGLEQSSAVMPSLHDVPSLSRHHSVAHDISLPLVTLAGTSDPVHTSTALLQSATIHSDSTRSSAQVDGTGYSIIQSAGLSFPETGSMRSFCGNNETLPAVIKAKNGTTYLRSTRILGKGSFGCVYLGMDAHSGRLAAIKFLPLPSDESGMEVVEAEVLILQRVNDTHVVQLLSYAFEGDTIVIFMECMLAGSLQNMISAFRTIPSSTARVFMRDVLRGLSKLHSMGIIHRDMKPQNVLLSFAGNCKISDFGASAWLQELARKESRGEVCGTPVYLAPEAARGNPEKESDIWSCGIMFLQMITGHLPYTSEQLASGAAALVYQIGSGIAQPNVPDDLDVLDAEFVRACLEKDPGKRTSAAGLLQLALFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQ78</accession>
    <name>A0A088RQ78_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial processing peptidase alpha subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_210370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698825.1">
        <property type="nucleotide sequence ID" value="XM_010700523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQ78"/>
    <dbReference type="GeneID" id="22574859"/>
    <dbReference type="KEGG" id="lpan:LPMP_210370"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210008300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_210370"/>
    <dbReference type="eggNOG" id="KOG2067">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277191at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF227">
        <property type="entry name" value="PROCESSING PEPTIDASE ALPHA SUBUNIT, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="1">
        <location>
            <begin position="51"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="467" mass="51596" checksum="95D5D4A0089932C4" modified="2014-11-26" version="1">MLRATSRLGIYEYQFGQPSLRSAFSTKIARTTKARNPGTVQSTRLANGVRVVSHDLDGPVTSIGVYADAGPKHDPIATPGLSYVMRFALQTSNMDSSLFQIDRTMRSTGNAYGHGEVCKRYLSWKAEGRRDMWEKPFEMLATGVVAPRFHESDVERFRDTMDNQLEEMRWQNPRDYAVDQLETVAFYKEPLGAPRMVPRIANDRCNHKVLLDHWAANFQPNRIVVAGVNVPHDALIAAYEKLPYKHSAEAPHHARAAAPKLSHSNEVAQFYPGRQNVEYESRAAAMGTVPDMQAEVVGAVGVPTYGRDEGTKQYATALVTREIYEEAMRSVHGSHAGPQYYGAQVFYRPYSSAGLIGYTVRGAPAAIEKMLQVASSAFPASVDEAAVKRATHCAHVRLLHDQVDMTRDYCDFLATSPHSVEALVQAISGVTKANVEEAMKKIVAQKPATYAMGDSFVFPMVAALNHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQ97</accession>
    <name>A0A088RQ97_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_190810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698077.1">
        <property type="nucleotide sequence ID" value="XM_010699775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQ97"/>
    <dbReference type="GeneID" id="22574135"/>
    <dbReference type="KEGG" id="lpan:LPMP_190810"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190016000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_190810"/>
    <dbReference type="eggNOG" id="KOG4568">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF83">
        <property type="entry name" value="TIP ELONGATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="2">
        <location>
            <begin position="41"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="103"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="183"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="335"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="451"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="647" mass="69964" checksum="D94FF7637F66075C" modified="2014-11-26" version="1">MSQFGTERSSAQPVPPIDSFVEVLPVAPQVERRRGILRFYGVTDFAEGEWAGVELVGCEGRNNGAVKGISYFKCAPGQGLFVRPNLVVSYATEIPALTLAAAVTADSAKMEVLEEELRVARREAVEREKLKDSLEESLHSLQAELEQLRAAASQAAAKVGTNNTEDNAAATAMEDDDDDLVAQVELEEVRLELQRQLKICEAELKATKQSASEAAAACAAAEKREKEAENARKLSEAAQAALQSRNVELEMELARVQAELSSAAAQPSQSAQESSEVAAAASAACPDLQTALRVKDTELLQPYAAPGAACHTHERLREAKVQEQERVEAAYASEIARLQTDMAAMKTEKEELQELCQLLEEELKEQKAQSDALTHLVEELGAAKAEAEAAVERARQSATQEKLRLARELEEARVCEVRAMAAVALAGEGVVGHPSTSSTTSEANPSLEMALLQCRDELDEARTRILQLRSTQQVVQELQLRCDELTEAMRVQRAAAQKSDNVARATLAAAQQQHAQQVAQLRDACEAAQREAASLATQLNLAAAAQGANSGHSTVAAALSGTPLDAFREARYEARIRSLEQLLLECHAARMSSALWDVSAPHTRAWRGFEVPLASLKESVGRLLDFSTREACVTSTKALFQTPTALH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRN7</accession>
    <name>A0A088RRN7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kinesin, putative</fullName>
            <ecNumber evidence="5">5.6.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_241390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.3" evidence="5"/>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699479.1">
        <property type="nucleotide sequence ID" value="XM_010701177.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22575548"/>
    <dbReference type="KEGG" id="lpan:LPMP_241390"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240020700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240020800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_241390"/>
    <dbReference type="eggNOG" id="KOG0239">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266699at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000206">
        <property type="entry name" value="Putative kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="KINESIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115:SF991">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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            <begin position="1023"/>
            <end position="1606"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="3">
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            <begin position="53"/>
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        </location>
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        <ligand>
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        </ligand>
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            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
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    </evidence>
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    <sequence length="3294" mass="345584" checksum="9CF9C41BADD5E089" modified="2014-11-26" version="1">MKRPTSVRQPAPANAQRASTVVGSSGAAASINRCISLYRAAPVLAAVNATTTTAASASPPMPSRPCGGPADSSNGSHSPKRSNVSSFLTPRRLNASAQKTVAAPPPPPPQHAQWPHDAVPNLRPIPFASPTPSGGTPSRRCARHIPALLSGTQPRSATVTTVIATKSSGSPRYEGGYEPPRVERLAAVGIFSAQKLIPKPAPSAIESSGASLPTDNFVGNQANSESANGAAQSTPFSAPSQLMTSPSAAACDRAKKRAAAKTHVKAVTVHRRSAPSAMTAIGASPPTLIPTKASQPRPLSARAIPVANKTSTAEVADGMLRAQPSSSYTSARLSSLPFQVSEATPPLAFATASRKNSAWSSDPTNRSVVLGASGATLEPSVTSRRPTWLESVDEEDTVVTDAESIPVSAAANPTYPLAGGFSTALRSAAPVKVTLRTSALMTTTAPAPEPAVVKPAKKRPEAESTFASAASTADGGGAGKDQERSSGPTAAVNAKAARRSLTPESISQVRKSRGMTQNTTNAAPTPPLSSSPQTLHQSIAMAAGVSSCTPKFSSSTGKTNRSTPARGAASPSKNPDMLRGGVLPRATPTTGAPTAPAAAAAAPVVTSAPFHASEVYSQHAATILSQTLSVVRPMAPVVHVRIRPVLPSIGESSKGRRVFFLDHENVMVTRTCPGISAANASSLMPPSSLVEPTMVRRSGTNGQIVPALQLSNLNSRTRSPSSGTRGVSAAPPLRAAAGRGGGGKVLVSSTDALRTAEASAPMKAASPACFYGKDLAQLHSLVAAESLMASKTSAVAAGADLPSGTDEGNIHVSPSSLSPASENLQPLSLFPPPPLAAHHNRTTSWTSQGSEERSPSSRLSCGSPSTSVSPQQLGFGSARSGAEVSMALGTFASVSRTRPWLTTFKSFTEEETSSLYATPRELKAASTSGGACAPSSTGRHCSSGGAARGGCTTPALQHRAKGPGIERKPCYGGVSLSTASCITERRNSAATITTGVSPRKAATTAPSPVSTRRRASRSILGASVSVSAMSIPTMPKTSGGFINGAKLAEEDAVAEPKEAHHDEGRLQQQQTPLGNCSISPPGAATCGEQHYSFEFVHDEEATQADVFEESVLHFADEALLAQNVAIICYGPTGSGKTYSMMGSQVQPFSTSRSSFGSTPFRASGEKRHHGGVVSTSCARFPPQSDSNGPTPPGPGNTGEMERQITDEAAAGVDGRGAGRDAHAVEDDDESDGASCPKLGSTWEYHYVKHTSKGNGDSAAAAARRNHQRYSHTDGGEGAALTSSAMMFECAAAPGSMTEMGILPRLVHTLLERRGEAITIRRDPGREVGGRSAHNLQSNSRPTSTLKRAGGLSLTLRDLTFYGIELYMDELCDLLDPGKRPIPTVSDTGGLEVLCQRINEARDYRISGSRGGASHGTTKTARTGGGMPITSLADLRRAYHLAHGNRVTARHAKNDASSRSHAIFLLQLDFDLIESTDEPRRRAGSGAASARDGGAAAPPLPSEHVQRVHSYVAMVDLAGCERVKQTKVEGAALREAQYINKSLSALSSVVLSLHHNNAHVPYRDSKLTRLLRPCLEGGRVLTLVHVAPCSSTEAISTLKFADQIRHIHIPTHALTATSSKHRELLDVFADLIDPMQGHWESQVRQAQLQLDRLCADVRLLYFSRAVGAIPHRTASKDALASDVVSEISAMSEVDEIISISSGDVSQEEGPQPLTENATEADKRRFALLTVMHRLMGPIHLHQRTSMRDAVRAIQCREEHRVLAHRQQVQRRIDKLQATLQELTTANAKLAKENSTPLPRDPHALELSRRIRESTEELGEYTKEQAVLISLTTALRQRLAAQDDLEAAVDEQLHKVQHRTEQAMRTLSAAVAAHPPGGPPAGSGATLPKEPTLPTDTSTTTALAMSSKDDPELRDIAHQQLSLAKELAALRLETACFEIGTGLWEGLWARAMRKEIITAMEVEVFAMERILLDRRAFSMMMTSDADVDGENGCVGDAETGLTALPLTPKAAAYPGNGLGSVERNERDTSVTAAEHHVSAPLMHPSPESSPPGVHLSVPVSSYSALWSRLGSYLHRRAESCNGSGRVATSHRGPNKVEGGAAVPLSSLVLQRSRRDRAVDLATTTASDKSVSFATNSFSAVASSSEGLRLRSTLAPVAGVVPSSSPCRGLEGLVPNPLTVLMTGEQQNQTQHQMGSISSLPSSRHNSNAAAVVAALMPLSLAGSYEEEQSMQEASLQMLLRDGIPCEVCCLGESASYTLQHYILPSSADAPLREEARHEDPATNFSAAPDRYPATEDSGATEKESDASWLASARKGHMTNREWSSSRQPCERPGGPTVGLCTTRQGRLRLVRIPRRQNFYVLEFLYTHQGLPMAPRLQAAVLGKSEDTFTSIPGKTHLEQMVDALPSVQGAAGRGGGGGSSGSTATQPQGPLREHRLFAIPLFDPTLHLHMHVLEEGIPNMTTPVAAAVGLPSGGDAPSVSGSTFEDASDPGGSVIFTSPSPPFPALCVARRPEDGPQLVVEVRGVPQTSSTCRRMITADTKQKPKSSQKRQQKPRSPKKTTARAGQAAGPALHSGQAQHAVGRSPSRPSASRAPAGTRAGVWSGLVLAKRLSSGGELMLPSSCILANTGCCSLVLRFPAPFFASSALRVERVEAVVGALCGILRPSLTAPEVRPSSSLSSSKQVGSARRRLSSSPWCTSAGGTERGGSNNGDRRRSSVSRSPLSSACAPPGLEVVDYAHIPYTLFLGSGSPIRSSPSRATSVGDGVEGLGYGPFASGHPSASFGNAAVLASASSSAISSDSLDDLGVLSGGVLGDTLQSSFSQGHGRYIATTMPPDTSLLQHNTSLNGLPRPSRGSSMLGPPAAPLMDQRSGATLQVQFYWIATPLNMESPHLDAGRKNSSGAGCSSANDGGGDNGAARRHTIGSRFPPQPNTHTTVSTDTSVEAAEVGVDRLVRSQVKAALSILAQFSYVLVDGRPRGDVADVGEGTAASSLGSTLTASFSAHDVRRPLVLEHGSHRRSQSEADAARFRDAVAVTSLLRQLDTYRHRIRRLFRQQLYDAEDIIGDDVAPPALQSWLSGELGRGAYLREVQGEVKRTVGLPASTVLSSTSGGAAPLLITSSDWHSRGDDRGTDAALLEPESGDAGPNTQVTVTDAREACVTTVPWTVWQWAYRWPLLHRLLRRDSVTRLGSGDACPAGRPCVSQAEGTSAWLPIAAHSSSSAALVTVTSSPFLASCSMVASPTFASSSSSSDEGFVMEGDWLTEAKLAARSKRVWLPEVFTATVPSYLENCSYAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RS54</accession>
    <name>A0A088RS54_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_240660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_010701105.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="22575475"/>
    <dbReference type="KEGG" id="lpan:LPMP_240660"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240012500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_240660"/>
    <dbReference type="eggNOG" id="ENOG502SPTG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264063at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="152" mass="16914" checksum="C30B42561DEA9BD9" modified="2014-11-26" version="1">MLHLSHINRFIAPSSLSPEPSQLLRRRQKSTVTTSGNLHAFVMEYDHRSAMPRLRRGPFHGDFFSRYLFSGSLVAGAFTAGGVALFVLTIAYNIGKPVLDAHRELLWKRADAANGRRSRENVEGPAATKEDDDDASPVEEFDDVIEMEQAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RS73</accession>
    <name>A0A088RS73_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclin 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">CYC10</name>
        <name evidence="1" type="ORF">LPMP_241860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98818.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699525.1">
        <property type="nucleotide sequence ID" value="XM_010701223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RS73"/>
    <dbReference type="GeneID" id="22575595"/>
    <dbReference type="KEGG" id="lpan:LPMP_241860"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240026000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_241860"/>
    <dbReference type="eggNOG" id="KOG1674">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="337735at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF126">
        <property type="entry name" value="CYC2-LIKE CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98818.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="708" mass="75188" checksum="DED63A441C785E6E" modified="2026-01-28" version="2">MSALETVGQNGRSHTTDANSHIGSSHAEDGSTSRVHYPSRLSPSASPLGEDEVEKPLICHFFRKQPPLQTGSAGCNESNSGLHTSVNGGSAGVGGCYCARGQEEAASSPTVKTSSAGATALSLSTTPALPPFPSIMGEPVDLFPLTPSVTMPKRHSKRSGRLLNESETMQEKHGREYRFLVPWLAYAIDCTIATHEVLRQRHRLPAHVSLPTSPSEKELNGAANAECSPPRCANGKATLPSPQAELNAFSTREVPAISVHDYLKRIVKYTYVSPSVLVCACLYLDRLLCMHECMLLHPYNVFKLFLTSTRMASKIMDTRTLNNRDFSVVGGVTNDDLNALEFIMVELLQNRLYFSRNTFDEYCRSLRLQAAHLGDEASDWGTETSMEMPPETRSGVQHQPTRPFLARCNGSNTRSRRSSSVSQNEYSMSAASQSGVSPLRSASRPAFPPSASTARSISVDTESLGPARAPASRGGSASVSARRHPLGTSHSPALPHVPHAAANGGSSPALGAMGDLSGRGVSGEEVLRVAVHTNNIYQNGNGAWTGQTPPNSAIVPVTVEEKVDDRARSISLSAPRCGAASSLDATGRPSRLLAASTGTAAGLCTTALNAIRGGCDTSSTASTAPTYNGTTTSSSRGITTSTEDFGSGSMMTSYGDRTPTRRAFAYTIREGVALPPVVRSGRSERSSNIMGSAVQGQRLPLPPDQPRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTM4</accession>
    <name>A0A088RTM4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_231500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699306.1">
        <property type="nucleotide sequence ID" value="XM_010701004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTM4"/>
    <dbReference type="GeneID" id="22575355"/>
    <dbReference type="KEGG" id="lpan:LPMP_231500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230023000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_231500"/>
    <dbReference type="eggNOG" id="ENOG502QWSE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270378at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="CDD" id="cd23092">
        <property type="entry name" value="mt-LAF12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="775" mass="85976" checksum="E2AFCFD2FD25BAE6" modified="2014-11-26" version="1">MLQPRTHGGWRVARRYTCLNAVINCIFFVEPSTLSFSAMRLPSRASASLLVVGLRGSNTCSHNTLHTATLRESVRRCQTKAADTASTTTSSIAPLDSASFLSALLEPERTVSLEDTTRTYATMDVVERCDVYDPSLPNVASPSPSTAGHGVAQWELGGESAESTTTAPAYPLRAAHAQGRLWSHFVGAQKTAVEGGLSESAAEPPAWFVQLCRDLYFRTDSTVADKRVADNFDVVTQASDLLADQAAAEASGSSGRRSGVTPPLAGVFSTATSAQRADDSLEVDPYTWLPFDLLDVKDYGVGPYEFPPTATYTLEQRVNLCLGQPDKEYVHFCSTYCFPQRWQIPTSMGTQPARLLVDPSCPTPVVFLQLSPDFPPVMWLPMKPSVAAIRGVLSSFATQAFLHREEQHAVFAQRYETAKRVMELQQLPTTQEGDVLRFMAYEARNLPYLDAPLREYPNQQEFFLGEYDDPERLLEHFDLCPFVFAISHLRTVTDLHAEHMTPTIEGAGVAPSLFRCIFSKALIQISVHLSAEVKLPPQDPEAFHFMWKDSQVVPKMKIPVFARVSWPDNRNLCGGGLLARRFNKLFGTEFASDTPVDAILSVYYVMQWAQRVPDLLGVAGMRQRVAELEAAAHLPEPAKLYPGTREIPNPEYTASERLGMHIQYLSHLGDPQVLETIQALLPTASAPVRMGCAKATLIAGDRELFRHIVSSEPPGRMQHYMTKLVVKRKTRDLVDPEPRLLEDQYEFAAPLWTKRGTRIDRNTLEGAVDAARLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTT2</accession>
    <name>A0A088RTT2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_262080</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700027.1">
        <property type="nucleotide sequence ID" value="XM_010701725.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22576111"/>
    <dbReference type="KEGG" id="lpan:LPMP_262080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260025500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_262080"/>
    <dbReference type="eggNOG" id="KOG0574">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267330at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="48"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="282"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="725"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1129"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1194"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1259"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1340"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1404"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1716"/>
            <end position="1739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1780"/>
            <end position="1812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1982"/>
            <end position="2039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2057"/>
            <end position="2109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2185"/>
            <end position="2204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2385"/>
            <end position="2434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2467"/>
            <end position="2524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2538"/>
            <end position="2612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2715"/>
            <end position="2737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2748"/>
            <end position="2767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2846"/>
            <end position="2904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2986"/>
            <end position="3013"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="3064"/>
            <end position="3093"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="3326"/>
            <end position="3345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="3740"/>
            <end position="3796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="3896"/>
            <end position="3933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="3959"/>
            <end position="3981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="4013"/>
            <end position="4039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="4125"/>
            <end position="4145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="290"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="725"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="786"/>
            <end position="800"/>
        </location>
    </feature>
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            <begin position="1129"/>
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        </location>
    </feature>
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        </location>
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        </location>
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        <location>
            <begin position="2006"/>
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        </location>
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        </location>
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            <begin position="2186"/>
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        </location>
    </feature>
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        </location>
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        <location>
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        <location>
            <begin position="2723"/>
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    </feature>
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        <location>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
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    </evidence>
    <sequence length="4199" mass="441019" checksum="7487CE01453ADAD0" modified="2014-11-26" version="1">[encoded data, 4199 characters]</sequence>
</entry>
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        <name type="scientific">Leishmania panamensis</name>
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        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
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    </dbReference>
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            <dbReference type="EMBL" id="AIN98654.1"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000063063"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
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            <taxon>Trypanosomatida</taxon>
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        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
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                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
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            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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            <dbReference type="EMBL" id="AIN99677.2"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="686" mass="74647" checksum="DE025E2E9D62B2D4" modified="2026-01-28" version="2">MHTRGDGDAHGQPRRPLGCVECDFKCSTGNEMSRHIHATRHGAVKCPLCETYIVPRGFFASLTKLIERHRDRQPSTTEVSGSPLHSPSSTSAVASSSNGGTKPLTTIAITHAHCIGLPDFKCYEKADFELPGSAQDYNLPSDFAGSAQGRGTSDALVQCGSENGGGSLPPFRCMECLNLCGTWTKATKHMDKSGHTLPLCVQCLVRLRCFGPQRPIKHEGSTGHCGFYGVFYTRRDYLCDVQAPRSAYNYSNSYTGLSTLQYKCVCGISFLHPLHLAEHLHRVHHATCIRDEAFCRRCEARGTLVEMMVHLRQGCMQAAPNAPTTGSSTTLPDTSVSMAMGSTAQLSMVGSPTSAAALSKDQEDQGETSGSGGDNATGVSSMIEVPGFSGASFLQWRPLLPPITSDDVPLMDESYAMSGDISSFHARTPQPASSSSRLATAKVRKASYVVLYQCRECLFLFSSWERMVHHIHATGHCRTYCCKCKLDLPQLVSHPTTHEASGASRSSAQLPTYGGAATSAPPLVCSTTLNDHLDHLRRCGDIIGFPTSPRSLEVLVDVNAECYQGSLDPAPDLFTGDRVVMAYQCPAEHLDCYEVFLNYGNLVEHLMATGHGSHLGSDSTEGAGNTQTARRLSSCYPMVTYRAKFTVLQLRDHFGFVQCSYCESAVPREEEELHEALCIMRRRMSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUA1</accession>
    <name>A0A088RUA1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">carbonic anhydrase</fullName>
            <ecNumber evidence="2">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_280480</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="2"/>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700389.1">
        <property type="nucleotide sequence ID" value="XM_010702087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUA1"/>
    <dbReference type="GeneID" id="22576493"/>
    <dbReference type="KEGG" id="lpan:LPMP_280480"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280010200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_280480"/>
    <dbReference type="eggNOG" id="KOG0382">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="429145at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03124">
        <property type="entry name" value="alpha_CA_prokaryotic_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041891">
        <property type="entry name" value="Alpha_CA_prokaryot-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF265">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839058" description="carbonic anhydrase" evidence="9">
        <location>
            <begin position="28"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="555"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="10">
        <location>
            <begin position="54"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="407"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="436"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="485"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="508"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN99682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="619" mass="66969" checksum="88128BFA365C4D10" modified="2014-11-26" version="1">MGTHSLCAAFAFVQLVLFLSVAGIVNGLDEQHSSYEGNYGTARLVLGRPDDSGASWNYANLNEWPSLCLTGSRQSPISFTNVNPDEVVTSAPLQRLKFSSACVFPREVTKMRIVNEGAVNTVSFERLGGSPDGLSECTVLDPLNSSRTYHFTGLHFHVMSEHQFRTLRPDAEMHLSFTTNDEKEKTRKTLTVAVMLKASTTSNSTSVRTLRHILVDGSLPMRHAMTTCFLKEDLALTSLIPARESYLLYDGSQTHPPCTENVRWVVMTSPIFISRVSLGRLRDAMDALLPNDFHRFGSARPPQTLNSRHIYRFDDITVPPGGSRRKGKLGDAWSRKKKGSANLSARVRTESMSAGSATDFYEHNNGPLVKPFVSLSSDSGSASGSHTVRLSSPLVLDAAGRNSRPLAPTAVKLDTEAAGSISESDAHESRSDNSEATTNSSSAPQANTSSSVSASSSNVNVSAESSHPSESSAQALSNDSKPQSTTTTTTTTTTTNSPSDPGREKMNASDSSSTADTGSGFGNFLESPVTRAWVFLKTFSINAFQAIVAYAKANPVRVGVSLLCIIALIFLFRTCYRGWRRPVYVVGINPTELQPLNPDNRFEFYGGTVPVRPARASLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUF2</accession>
    <name>A0A088RUF2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-directed RNA polymerase II-like protein, putative</fullName>
            <ecNumber evidence="7">2.7.7.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_271550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="7"/>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700242.1">
        <property type="nucleotide sequence ID" value="XM_010701940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUF2"/>
    <dbReference type="GeneID" id="22576333"/>
    <dbReference type="KEGG" id="lpan:LPMP_271550"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270022500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_271550"/>
    <dbReference type="eggNOG" id="KOG4392">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10248581at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06926">
        <property type="entry name" value="RNAP_II_RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037685">
        <property type="entry name" value="RBP11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008193">
        <property type="entry name" value="RNA_pol_Rpb11_13-16kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF16">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01154">
        <property type="entry name" value="RNA_POL_L_13KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="6">
        <location>
            <begin position="41"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN99535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="134" mass="14901" checksum="54D885C484C4A649" modified="2014-11-26" version="1">MAVPHGMLISRNDITPDSLVDLPGDRKIVEQISNTMANSSLFKMEKEDHTLANLLRMKLHESPFVQIAGYRVPHPTKHNVELRVQTGSNGTDTSIPAPKKALQDAIDGCLKDLEMFEEQLRREAQLKGLEASPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUW8</accession>
    <name>A0A088RUW8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RNA-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_252010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699771.1">
        <property type="nucleotide sequence ID" value="XM_010701469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUW8"/>
    <dbReference type="GeneID" id="22575849"/>
    <dbReference type="KEGG" id="lpan:LPMP_252010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250022200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_252010"/>
    <dbReference type="eggNOG" id="ENOG502S5SC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270130at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="230" mass="24520" checksum="EF9B3E19C28EA527" modified="2014-11-26" version="1">MAARLLEPTHGSAAGLTPNVLIISGFPWYTSELAVHRYLTDIYPAAEPVTTRLYTNPTNGASRGHCFVEYNLPPSSAAPSTSAVAATTAKAWSGADLGATAGVSTVQGSSGGDGAVDALLPPVLREVKRRVEEQPYECIYLKAHAYVLTSKRWSRAGRLPELPTDPSAVRWHGRAGVLVGYGDEGFLVRAGRELGLPNTVTADGQVQLEQLRKRLRTTSARRASGHLSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUW9</accession>
    <name>A0A088RUW9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="3 7">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_280240</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:18977"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.1.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="3 7"/>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700367.1">
        <property type="nucleotide sequence ID" value="XM_010702065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUW9"/>
    <dbReference type="GeneID" id="22576469"/>
    <dbReference type="KEGG" id="lpan:LPMP_280240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280007700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_280240"/>
    <dbReference type="eggNOG" id="KOG0042">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264015at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="entry name" value="Alpha-glycerophosphate oxidase, cap domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985:SF15">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00977">
        <property type="entry name" value="FAD_G3PDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00978">
        <property type="entry name" value="FAD_G3PDH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 7 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="8">
        <location>
            <begin position="69"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-glycerophosphate oxidase C-terminal" evidence="9">
        <location>
            <begin position="471"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN99660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="608" mass="66751" checksum="D173ECC6A8B1620F" modified="2014-11-26" version="1">MAVTAAKYIAGACAVAVGGIVGFSYTDPTWTRRRFDTNKCPPLKYETVPTREMCVQALEAHSASTNPLDVLIIGGGCVGAGSALDAVTRGLSVGMVDKGDYAGETSSRSTKLIHGGIRYLQKAVFQLDPMQLKLVAEALRERTIMIHQAPHLCHSLPTLVPCYHAIDVGLYWCGTKMYDLLAALYGGTLEYSGFLFPYDAMKAYPKLRKTDQDNNVLLGAVRYYDGGMNDARLCYSVAMTAACYGAATVNYAKVKQMEVIKDDKGDELVRTTIEETITKKTIKVYSKSIINAGGPFSGEIEKLAKSGERQLDMFPASGTHIVIDRKYCPKKHEAMVVPSNDGRVVFAIPWLGGCMLGTTDHKCEVQSNPMTSQADVDFLLENIKPFIGDVPREAVRSAWTGIRPLAVPKEQKLKGGGTQNIVREHVIAVDPQSHILNITGGKWTTYRKMAEEALDSLQKTIMKDKVDFKPCCTMNMVLVGARNLDKVASTAPLGIPEDVHKHWRSNYGDRYEEVMAVAAKDAKLMKRLANDSPVVEAEVVYAAQREHCEHVMDFIARRTRMAFVNVEQAEQVVPRVAELMGQVKGWARSQRNAEAAAAYSALASFKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVH5</accession>
    <name>A0A088RVH5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_290780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00029.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700686.1">
        <property type="nucleotide sequence ID" value="XM_010702384.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22576842"/>
    <dbReference type="KEGG" id="lpan:LPMP_290780"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290012000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_290780"/>
    <dbReference type="eggNOG" id="ENOG502RG4C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273389at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO00029.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1585" mass="172404" checksum="1C92415E2E5E6098" modified="2026-01-28" version="2">MLHRTRLSRGPAVIAGAFISVHFKGLGAYDYPSSLTWPPPQEDDTEERRDGVLRSPAAPLETPQLTVRSAEYHSHRRSPFSVLRSRQCCVGRCASGVLPTSYNTAAAPSAGGSSPKLGPCGDRLCCCSALFYPVLPSYSSSPSAPISTSAPSSSAEEGVWRARDDFLWALKLADVERLLRSTITEEVYARLLGSTGATATVVLTCNDLLTAAQRRAEGPSAVAASAASGASLPAMSAYVARLLLSADEDNRIKWLQEESAAVEHRGYYARAPSLRALLVMWSVQQQQQRLRAAALGGGDVAAGDLPHGDITGADPRLSTLAAARTPSFLIPPPTMMDIQHILMRMEERHIEVTMSDIAAIAAIGAASSGPGTSIPSGEFWGVIARQLQPQRLAQVLKAHASTPSPSANDSGASCDEALALQHVLILSLLLRYISVANAELPSASTAPSASSSVWASSSTASSSSGSANSMLLPMAAFEAASEVIQLRRLLTVPHEGDKATSEGSTHSSTPPSAAHEALLTLCDEVLKHAYALAERSQISVTSPDLPELTAWLLREMVTSAACEFHFKRLVDRSIKEALIALEKSGLVNRSLMNLQVVVRRVLPLLESCGSEDLYTSVLSDVLSALEEKARRDRYAFTQEDTLYLAELGAKLFVSDSADSTAGGYGLFDQTARGQMEELHVMDGSPWALCVLSYHSLKEMVQGIIRDQRRLKQQVQEQLRQLSSSNTLSTVMTGSTEEQGRRHACSDGNGARVSSPSSPPDSEASSTARGDAVIDFSAGSVAAETTGKEGFTTANAAAPSDTDPTPAPAAPPRISVSPMLRQRFLILIEELVKAQVAESSRDSERPIVVSTELFAFVTQHVPVPNIQDEYRRKIFLLVNVAEAPETTRRRLAERKEELLLSLDGKNQKRRRRRHVRCDTTVSGAAEEDAGREDAHAGPGSERAGRDNDPHGGANDIPAELRFLVSSLPLTLSPWASVMILREVLAESAGRNPRYTYVLNAAIDLQLPISTTRSRIATTLNMWRFLNTQAHKLSLKENVMMKQRCAWNLPMAYVLSSYWSLLTWLFLASIIMLNVVGIDFESQIVANSLFRMFTPWEEICAPQTAEDKDTWTTQAVADLASDYFEQAEIADRRREEHGLSSTDAFLSSASYLILGYDDQRRPMTVIPIGSDRTAPAEDRISEEYAAATAVLRELSLHTPFPFFLDIERPLPMEYVESRIAERIRRVSNDNTWFLPRMVIRTFTLGRQYTEHKLVLHTCTQANLTRRRITFLLYVHDGVPVTPQFIQRLYDSFLSRHANLVLVVHESSLLKGGTTPVALAKVGLPSTVSGTSATIASAAAEMIDAVLPSDLRDPLSFSAAAPAGHPMRVLPYCRQYYTSNGSVIPGLQRVADAERPEGGGDAVEKTWRMFALRSVRRWWEGPLAGSDASSSASTAAALTACLPLFASAFSSRRTSLHRSRERQCKEAEEEAAANKQRQSSGGRMFAVAPWVTWWRHTLSGVASATIRMMSVHRNDGWEEEAERDTEAPHRSATTSLTNESPPYEWSHSDQAAAAAAATAATEDDRETEAGKDGVSVPVTVLRRLMSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVN7</accession>
    <name>A0A088RVN7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleosome assembly protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_292360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700840.1">
        <property type="nucleotide sequence ID" value="XM_010702538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVN7"/>
    <dbReference type="GeneID" id="22576999"/>
    <dbReference type="KEGG" id="lpan:LPMP_292360"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290025800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_292360"/>
    <dbReference type="eggNOG" id="ENOG502S24G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275780at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="184" mass="20955" checksum="F85A9EF152D275D1" modified="2014-11-26" version="1">MELSQSTVQVISKFTDDLVNVDQKCDEEVTALRLKYRSQMEPLLMERRELLKGVGNFWSGVLSSPETPISELLNGTIDPKIIRAVTDFQVVTRTSGSKLYRNIIFTFRQNMFVEEGDVSREIDTDMKTISLHPLKWKPGSERARTDSFFAFFTANFSSDREAVSEVAEALDIIYQNPFLAVEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RW44</accession>
    <name>A0A088RW44_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_271070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700196.1">
        <property type="nucleotide sequence ID" value="XM_010701894.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22576285"/>
    <dbReference type="KEGG" id="lpan:LPMP_271070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270017900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_271070"/>
    <dbReference type="eggNOG" id="ENOG502QT9A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="239878at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26312:SF222">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26312">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1412" mass="154933" checksum="AD6F2FF1D24E8FFA" modified="2014-11-26" version="1">MRSRRASDPSRRRVTSKQEAARLLQSLAGNTSSTATSVISPISSHTADEEGKDFIRGTFAGSSAANTPATTPPRRLRRPTANLPSTLAAKAEIAESGSSTTAQLLQHLQLTPFVGRITERVKAWASSLAEWGQPTFDPALREWGQQLSMSLRRDSFADCTAVQHAMQQRYEDQFGHNREDVAFLTLYARVLVNNAMFCLTSFETYRTTQLLCEAVHVAKEAYLLQRRLAHDKARGETGTSTAAATADCPQEQCAVGDPECHLFFLRVLLANAYASDQQYWKAVEQYQLALSTMERNPMWCPGQVAPGLVSPLPFNHTLVTEDAKLFYEDSVRVDHAISQGRAQLLLLQSKGSTASSARLLQVQLAMARLHRHAGQYAESQNLYESYLDGVTEHMESEDVGGAMLELGRLLLYKVKNGDAAVIYLEAASSILLEDAESLLQAAESHGDRSGSDRSKEVTSAEARIAAGNAAHRAAGGLIDAAIAFHAVGKTGQAIGLLEGCLQLLDRANLGLISGWVRRQYADMLATVALVDRALEEYSRTIELLRDGCGNSVAQLGMAGEMVPLHSAEVEGQLAFCLQTYVGDHKRAIKHYRNIVQGWHKKDASVTGAQVRLNKRARRQRAAAAAAAAVNSTAAGSMSLSDGATFTSGQTLAGSFPALPRVDLSFQPDMLHWVLSNYVACCERVGAYAEAIGVQSRLIEIEGALGGGVVESYLKLISLARQAGDMEKTLALCFYVFFLPDNMMPSETRLSIANSFASCCHRLGNSRMGSVLLQAVQQVRGDHDSSSLARYAMGLKTLDPSDRVQLDGVDIEASIDSIGCVFRRAASIVVADMVVNSVEDEEKASRDHCRASGSGSCVAEAVLKGAGKETSISPSASPSLWTQERLDSALNGLIVLSRGAFFFHQNRFMKDAEELYASALQHVDHIIASVPVLTARYEREMGILLVNYATLKSATDPRLAATLYERAAEVCPTYLEVAEVVADVFVQSGDYTKGFAYMKRVIRANPSAATEMHMRLARLGMGTAWETMSYGERMEVMEHLLKSLGVAPERVASAFAAEAKRLEGNANKINMTMSLGNLAPLLLDGVASCMSEDAVCFATYVVQTRFQEMQLLNRMYRRALLRFPQHATLLVNYATLCMHSGYHTLARKYIAKAYAASSGDLNCTMCYAHYLCRSFDDRQVGCGESLYARFLERYPNAAQAHAAFANYMAGVMPTPFKTELHFKAALELAPTSEDVVLQYGQFMWACTDSKTVYANDEVHRRVFDRVEQLFKEAVAINPNSFTACHQLGTFYANRPNCFEDAMTMLQRAHKLQPGNIEVVRHILAVLHRECVRIQKEELSRGSAVALQGLRAQSFSGRLRSLVDATKDTFEHVLRMDPNDKATLEAYARFAVEVLQDPKLAAAIYRRIEALNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWF5</accession>
    <name>A0A088RWF5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_302700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701293.1">
        <property type="nucleotide sequence ID" value="XM_010702991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWF5"/>
    <dbReference type="GeneID" id="22577323"/>
    <dbReference type="KEGG" id="lpan:LPMP_302700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300031600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_302700"/>
    <dbReference type="OrthoDB" id="258422at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO00493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="88" mass="9518" checksum="360597EAFEADE9EB" modified="2014-11-26" version="1">MMTYSNMINNTVTQHSIAIAPGGMGVAKRRTFMRNGVEFAIAITAMHLKDSQTTLRAPFPGVNSPTADYKVDIVQKGHSLKFTTCASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWI5</accession>
    <name>A0A088RWI5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_303010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701323.1">
        <property type="nucleotide sequence ID" value="XM_010703021.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22577354"/>
    <dbReference type="KEGG" id="lpan:LPMP_303010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300034800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_303010"/>
    <dbReference type="eggNOG" id="KOG0198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06606">
        <property type="entry name" value="STKc_MAPKKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001272">
        <property type="entry name" value="Protein kinase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584:SF369">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1090"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1196"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1234"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1280"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1342"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1381"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1407"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1560"/>
            <end position="1819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1854"/>
            <end position="1879"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="1588"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIO00523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1879" mass="208237" checksum="5D6F77D68C047E2C" modified="2014-11-26" version="1">MLWSDFESPLCDLSGFGGQAAMGPILFAQATAVHYYGSVYYGLTEEMVQRGGSTFSIQLSIPTFPKNITLVRSIMVSILTDSVRLVDDTGTAVRPPRHSAHGEAAVHELNRTNAWPWWRRLVEDILAHSTIEVSPNGDAVKVTFAGRKWVLPAHTSALIVPCLPFSLFEQLGRLGLQDLPNNCLAGDAFLVSKKLLLQLDEARWNPPPAMFVTGGSISIPLIGAASTVSDKFALERQLRVMEGHTCLHTRSAFVRGSHWAIHDNAYRFTPHRGGVQSLCYTPYPDTLPFLYVKLMSSYEVAGPEGVSTDPPQVHADLEFTGTIYGTNLTERDTAVITDELCSDFTSENVFFVDLFFSSSSRVSFLGTFHKRGIYHVCYHREGSPMYVRVSTLLVERGADVVIDSDSPNVLIDQDVKLLQSASVTRLNVQDRGSLNLRQRSLNVSHFVWSGGSISGKGLINCTGYSKITTQGYETRQLTVPLYNYGEMTIDVQRLSMELEGAIHNYGNLTLAVSSMGADSISSVRSSGRHNAITNYPGGVIRIIALDERTYALLTGRFVFQGGSVVLLGKVNLTDASSFAESTVTLKSGTFLTAYNVHLGGTVVVEERSVLTLMRGCVFVSATVSGDGVVRLLGDDVVLNSLTMKGSIRALFGVGLVDPISVVVYGTSQFGEDTLVHVTNANFVTSSGLAKVVFHGRLLADLITVRFIGNMILQVSGVAALYGNMSEDALNFHRAFTKLAGYSLPLTTSFFVPANATMFVIDTSRLDEVVDLSTRDDAATVKDIVPSLDTFNNTVASDPAVVVTQVCEVYLPMSQHLEMRGRLVLRGCVQAPSGGTINGAVLKLEDPADWALLHETFCIFSELETLSLLCRHHLRIAPPLHSGLALGEKVYLRSSASFSLDEIALIHSHTRVPDPVPIVAKDAIIVRAGSTLSLTHGMVMARHIIIEGTLVVSDPRNTVLKGLVEVREEGIIELHGVSAGSCINELLVEGRLYLAPNARALHFRCLSASDDDIAAEDSDTAQASLDGTDTIKSVDRLDAQLRKRALANLRPDMTCPDDVILDYDSRRQFINVYWMRQAYDPPADQPTLQDMMWMTFFGIACCFGTFHILLSMWGYTYKKWWNDVRSPCPLQLTLTWDELSYSAINYLSFCRLIIINFLNAMAAFHPGLPAPLPSVAGILMRGMGLLMPHHQTPISRSRKVGLFYIVWLLAFLYVKKRGSWLISYLRRRQPFLLDVVQKLYTVLTILNFIFLGPLMSSVVDAIAWPTLLRNVPTYEPMRQDIWVAISVISFLSMGVMTPSSILTNQILIPHMDLRVRASNMFLHFSTQMWETVMWKVFYNNPMCVVFNCIFFQLVRLTFLWRFPGTPYKNVNRFMFSLSLQSFYVYLSLTVYAVLVRSGVYTSCTQGTTMFRVVAAALVISLFINFWRNVLFMQEQTTATGDVSIDALRCSMLQIRNRIHDLKFEVYACVDPIERENILNAIARMRIEYLEKQERYRFEIHRLLRPFIFSGSDFDGDTPLQSHSSVASYSNDYGNDASNVSPAMSHNTQHSNLLSVEEMETFSCGPALGKGSYGTVHLGILTNGKLMAVKYVSVVSQSPEALASVKAEVNMLRELSHPNIIRYFGAHTIQDTMLVFMEFAVGGSLTSIVRKFTHLTEPVMQLYTFQILKGLQYLHDKGVVHRDIKGENILIDGYGVAKLADFGCSKSLANIANASQEGCGTLVGSPFWMAPEVIRSEAYGTKADIWSVGCTVVEMLNGGEPPWREEFDNVYSAMFYVGSTNEIPQIPEETSDPCRDFLFLCFERDVMKRASADELLQHPWLKSAAAASHSVDTSDNFLSFSSMSSPLPRSVYDGHRSAGFSRNTPDSSHEDLTLLMNGSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXY6</accession>
    <name>A0A088RXY6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Enoyl-CoA delta isomerase 1, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">3,2-trans-enoyl-CoA isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">LPMP_312080</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Key enzyme of fatty acid beta-oxidation. Able to isomerize both 3-cis (3Z) and 3-trans (3E) double bonds into the 2-trans (2E) form in a range of enoyl-CoA species, with a preference for (3Z)-enoyl-CoAs over (3E)-enoyl-CoAs. The catalytic efficiency of this enzyme is not affected by the fatty acyl chain length.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(2E)-tetradecenoyl-CoA = (3Z)-tetradecenoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:29847"/>
            <dbReference type="ChEBI" id="CHEBI:61405"/>
            <dbReference type="ChEBI" id="CHEBI:61968"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:29849"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(3Z)-decenoyl-CoA = (2E)-decenoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:77195"/>
            <dbReference type="ChEBI" id="CHEBI:61406"/>
            <dbReference type="ChEBI" id="CHEBI:195601"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:77196"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(3Z)-dodecenoyl-CoA = (2E)-dodecenoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:23716"/>
            <dbReference type="ChEBI" id="CHEBI:57330"/>
            <dbReference type="ChEBI" id="CHEBI:58543"/>
            <dbReference type="EC" id="5.3.3.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:23717"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(3Z)-octenoyl-CoA = (2E)-octenoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:46044"/>
            <dbReference type="ChEBI" id="CHEBI:62242"/>
            <dbReference type="ChEBI" id="CHEBI:85640"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:46045"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701596.1">
        <property type="nucleotide sequence ID" value="XM_010703294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXY6"/>
    <dbReference type="GeneID" id="22577634"/>
    <dbReference type="KEGG" id="lpan:LPMP_312080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310027700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_312080"/>
    <dbReference type="eggNOG" id="KOG1683">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276466at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000034">
        <property type="entry name" value="Enoyl-CoA delta isomerase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF45">
        <property type="entry name" value="ENOYL-COA DELTA ISOMERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="10 20" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="31"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00056147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="AIO00796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="343" mass="38639" checksum="4624A0DDC8D40E5A" modified="2014-11-26" version="1">MRRAISSSLTRCAGAAGVTSALLQLPQHRLQSQAPPGGLQQGCQQAPKAAHTGHEHSHHPEPEVEPPRKPTEVPKFVRINTSDKGITNVQLARPPVNSLSLEFFQELNQWMLWLGSNEETKAVVISSAIPTVYSAGLDLAEVHNPNPERISGFWQSFQEMWLIFNSFPKPIIAAITGNAPAAGCIIAMGCDYRVMARGPKDTTNNNRLYRIGLNETKLGLVAPPWTMPAYAYLLGSRQAERMLQLGETPLADDAHKLGLIDEVASDEERTIEAAYKQAERFLSVPQQSRWMARDMMRREYLQMLASDEERNYDTEFFTQFVMNPEVQHNLERYLERLKSRSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RY56</accession>
    <name>A0A088RY56_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_320570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO00944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701744.1">
        <property type="nucleotide sequence ID" value="XM_010703442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RY56"/>
    <dbReference type="GeneID" id="22577798"/>
    <dbReference type="KEGG" id="lpan:LPMP_320570"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320010500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_320570"/>
    <dbReference type="eggNOG" id="ENOG502QPHS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277199at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39666:SF4">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39666">
        <property type="entry name" value="RANBP2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="321"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="383" mass="43560" checksum="E90B39A7BF9D970D" modified="2014-11-26" version="1">MSASGTTTLKGQSDLRYARTVSFHPESSFHEQHNAASQRLFHTSEPGWESRESNSGYAAQDDGDTANEGIHRGYYERLQRFYKKYNPQKLCNVEKLLCECRGEEEQLFAILVGKYGPEPEDESTTLCADSVFSSEGDSVMHYSGKRCQFPKKVMPEEGNTDCETPYWAGASSLIGDRDLLALLSNLETSNVELQKCYMGVFGQHPGDCWNGMVYITRAEGIASVDTPFLGHSWVGTLGSGKVLVHESKKFHRTTLYCTEECQKRGNHERWRLSVYRGDLNYLILLRTVWDPVVVPEPLPLNRSNHSERELHSSFDAFPTRLSSMSSVDSDSSSSRQPLQPQQQQQRFMTLDSVQFTKLLEEVESRIMRHLEVLESRISRLENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYM5</accession>
    <name>A0A088RYM5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_301800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00405.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701205.1">
        <property type="nucleotide sequence ID" value="XM_010702903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYM5"/>
    <dbReference type="GeneID" id="22577233"/>
    <dbReference type="KEGG" id="lpan:LPMP_301800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300022200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_301800"/>
    <dbReference type="eggNOG" id="ENOG502S9R6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267465at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO00405.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="875" mass="90434" checksum="05062AF48A0C0729" modified="2026-01-28" version="2">MRSVAAAETVAAPSGPETSIYVCASVLSVSSSAGCISCAHMSQSSLASSTASEDASASPSTDSCDILPASSLSALTDAEDTAATASVTLSVFTCSSVDGDADAGAPPVLHDSMWSLGAPLVNSSAITTVMAVATDVLYQPPEDLPSLQPLPSTNAVQLRGSTANVAVMEHESGTEALQAVQFVSLSNSHDDPGSLGEALSSTATKIPSSPAFSGLVSDASTLQHGVASSLPTATLAPPAEFSVLFVPTVATDPDRPNDILAPSLAGASLASSDSSSLSQSQERARTTPIVACDSAEATTRVEHLCMGISLPIGESVSSPAICCTTASTGGQSAAHSQPSPPLADLSMSAITPDRKNAVVQLPRVGNAEGGVSGEEALLDSAETHVVFGDTRIAEPTLSLSSVTANRHGGESPQAESGAAFEASTKATPLLTQPADVSEKPTLPTAPASSGLDAARHDRSARKWCAASAESPATPKAANAPPASRKRRRVSLMSPHRQSRLPVEQSESEEKLTEEAEPAPSLSAHPGGGPLLATAVECMSTACAGEGTCKRFTWAQTHAPATVSLAVRASGDDGDQEEKRQVVRVPPGEAHKRDAADVDVGSSSLANERVEPLKDLHKPYDHRARIAYGAQADSTAHPCPRNAPLVTSTGHVGADSDEEASTMSPPQFSVATGASAATGRTTANSLSVSNLTTDSALATSGVNSARSKRSPRNAQGTTSAPRKETVSKVLTKEAVTPAPSLSAPSKPVLNLAGVNVQALLAEGTDPPPLYTRRQRRTRRRSALAEDHPLFAEHRDLWENDPSGRIFPRAPFASDADVLNSLIEWTDSPALVYAQLLWRYVPGLFLRLAMHDGDVTPCVKVEPKVDADTRMKQEKME</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYW0</accession>
    <name>A0A088RYW0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA uridylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_322590</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>RNA(n) + UTP = RNA(n)-3'-uridine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14785"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17348"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173116"/>
            <dbReference type="EC" id="2.7.7.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="2.7.7.52" evidence="3"/>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701944.1">
        <property type="nucleotide sequence ID" value="XM_010703642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYW0"/>
    <dbReference type="GeneID" id="22578000"/>
    <dbReference type="KEGG" id="lpan:LPMP_322590"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320032000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_322590"/>
    <dbReference type="eggNOG" id="KOG2277">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="407432at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050265">
        <property type="term" value="F:RNA uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF41">
        <property type="entry name" value="TERMINAL URIDYLYLTRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="9">
        <location>
            <begin position="37"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="8">
        <location>
            <begin position="247"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIO01144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="356" mass="39909" checksum="EB96474BE20D62E0" modified="2014-11-26" version="1">MKGKARRSIAALGDVRAAVLRFCGEQLSRRLDTKPVEDVHQKVSACVQQVDPTMTPYIFGSTVVLGVHEQGSDVDFVCLSPADVQDGKGADAVSEVAKGLQSGFLFRLSEVVKREHYLWDIELVRRTRVPVLRVKGGLGVDGVSFDVTANRRNGVRNSALLRAYFTQCPEARWLSMLVKQWSKKTGLNASVDGGCITSYGWNIMVVYYLLRRKLVKLVPVESCDVANIAPMPPYMPLETPQQDGQALAVMLMDFVSYYLDEFTPETEVMSLTRAAGETTKEMLSWTKQAEDMARIRGERIHYRWCIEDPYEFDLNVGRNVTPFKLMLLRKHLERAQETALLLLATQPVSAEAKSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYX0</accession>
    <name>A0A088RYX0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_322740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701959.1">
        <property type="nucleotide sequence ID" value="XM_010703657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYX0"/>
    <dbReference type="GeneID" id="22578015"/>
    <dbReference type="KEGG" id="lpan:LPMP_322740"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320033600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_322740"/>
    <dbReference type="eggNOG" id="ENOG502SFFP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265347at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="609"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="394"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="635"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="665"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="715" mass="77139" checksum="CA0E85267FB9F6DB" modified="2014-11-26" version="1">MDPLKKILCQCRSALLLPPSSPHPTQTCALCFVSSVLSYCASCPPLSSFSAFCRPFYTCETSPRFALAFQIVASSSMTDKGDAARAYCANLAATYERLAHDLAIPLIDQELYSCLFVCPLLHEHCAEAQASFAKGTGTSTMTFLSSVSTVDRHGDALVALGGTELVVAALCEHEQQTLLVMQAIALRESVMSRIWGCCNSYDDGQASVEAAQFTMLRLLEEHQIATLLMVESVLAWRQALSRPYPFLLKKGDNYLMNVVQDCAALGATTLVRSLANVRLEHDPLCVKVDFCRLLHRMEIKHRTRLVNSGAMWRLGLQPLRPIASSQPFRGSTAGNSISAASLTAVASPPSDASSEARDVAPATRSYAGTSLDFLTEVSRLAAVLNRTDGRRRTSLPPLSTATSTSSSAAGVSNNSAPGAAHRHFPFPSPHGDREAREQKQRRLLTATRVLGEEAFIQRMLIEELYPLAHEQERFVPLLKVAQLFSADGFGQVEKNIPEDSWPLEKATWSSLATTGRRVNRLNCMSTAREVLQANHLLPAWERRMSNSITDLATATSAYSVTPTTSVSLPAEGSVTPFQPTATQAQPCSFAATTTPSSCHSNSFKNFDVASSESFGKQREPTSSPKERAACRSKLSPPSNSTSPKFSSSPAVAPTATVVTSQAGPASSSSSSSHASSATSSASSFQTPSHKQSLEELRQQLLAEHRRNSDPASMIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZC6</accession>
    <name>A0A088RZC6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Paraflagellar rod component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_330660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702159.1">
        <property type="nucleotide sequence ID" value="XM_010703857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZC6"/>
    <dbReference type="GeneID" id="22578219"/>
    <dbReference type="KEGG" id="lpan:LPMP_330660"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330011200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_330660"/>
    <dbReference type="eggNOG" id="ENOG502S6CV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="239036at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="CDD" id="cd22648">
        <property type="entry name" value="Q4D6Q6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39665:SF2">
        <property type="entry name" value="PARAFLAGELLAR ROD COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39665">
        <property type="entry name" value="PARAFLAGELLAR ROD COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO01359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="14371" checksum="2CE4AF2CFBB03273" modified="2014-11-26" version="1">MSRNLIVNMFFNSPEIQILGPVQENTIERLNSVLPASTTSTRSIRNSQPKFEYLSNPDHWRIKLDGQFCDSEGVSRLMVLLLDALEEEGGWTLVSSMASSPHTCGTLQQDTVESYKFFFSRYEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0G7</accession>
    <name>A0A088S0G7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ARMET C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_341080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702534.1">
        <property type="nucleotide sequence ID" value="XM_010704232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0G7"/>
    <dbReference type="GeneID" id="22578613"/>
    <dbReference type="KEGG" id="lpan:LPMP_341080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340016400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_341080"/>
    <dbReference type="eggNOG" id="ENOG502RZPF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5597848at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019345">
        <property type="entry name" value="ARMET_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10208">
        <property type="entry name" value="ARMET_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839176" description="ARMET C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="ARMET C-terminal" evidence="2">
        <location>
            <begin position="25"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="219" mass="24372" checksum="B017877A1086333D" modified="2014-11-26" version="1">MKAFFITVLVAILAATLVSAGMTESDFKKMKVKDLRGFLMDRGLECIGCQEKSDFVRMAYQHRDKSPIGSAKKREIPSKKFWEAWSDIAKQECQNAVKRRGNDADAEPFSIICDTIHSAADSYLMQHGRRVANQLKKTPLHLLETSFKDVYYEAGLHLFQTLADYCLASPSSQTACQSLGSVLSTMDGSSGANFKVWTTNVGIENTNPMYDIIGEHADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0K5</accession>
    <name>A0A088S0K5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">60S ribosomal protein L26, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_242030</name>
        <name evidence="7" type="ORF">LPMP_341520</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699542.1">
        <property type="nucleotide sequence ID" value="XM_010701240.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702579.1">
        <property type="nucleotide sequence ID" value="XM_010704277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0K5"/>
    <dbReference type="GeneID" id="22575612"/>
    <dbReference type="GeneID" id="22578657"/>
    <dbReference type="KEGG" id="lpan:LPMP_242030"/>
    <dbReference type="KEGG" id="lpan:LPMP_341520"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340021200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_242030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_341520"/>
    <dbReference type="eggNOG" id="KOG3401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="260276at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000009">
        <property type="entry name" value="60S ribosomal protein L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005756">
        <property type="entry name" value="Ribosomal_uL24_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="Ribosomal_uL24_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01080">
        <property type="entry name" value="rplX_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11143">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L26 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16906">
        <property type="entry name" value="Ribosomal_L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="114"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="114"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN98835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO01779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="143" mass="16182" checksum="59443F9E4376323B" modified="2014-11-26" version="1">MVSIKCGSRRKARRAHFQAPSHVRRVLMSAPLSKELRAKYNVRAMPVRKDDEVIVKRGAFKGREGKVTACYRLKWVIHIDKVNREKANGSTVAVGIHPSNVEITKLKLTHHRKAILERKDRSSKSDKGKGKISAADKAMQQMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S142</accession>
    <name>A0A088S142_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_323730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702055.1">
        <property type="nucleotide sequence ID" value="XM_010703753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S142"/>
    <dbReference type="GeneID" id="22578114"/>
    <dbReference type="KEGG" id="lpan:LPMP_323730"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320044200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_323730"/>
    <dbReference type="eggNOG" id="ENOG502QVQC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273424at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808:SF30">
        <property type="entry name" value="SAM-DEPENDENT MTASE RSMB_NOP-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1217" mass="131396" checksum="F1708609C0AECD18" modified="2014-11-26" version="1">MLSFTHRVVGHRARQRLPRSLQGLPTPNVRRGWGNMKNFSNEEKRELLHGAWRDATPIRLVPDPSDRDSGTASEPITFATDEAADRYLAEEEEDEMAEVRESTLDLAQNFFVELATAADEEVDGAQMPPLPQSDEERRREMRDAQREFFGDFYTEQGIIDKSERYAFVDTMLRPSRPLFLVNSVLPLARLTMRDQLEAHSTVSTHLNRGTAKDGSTGFAGELHPLPVFTPTPFDPCLYAVPLPPTQAFGAPLHVRFSSSTSRWKPPMPHSDADAQAIGDGDASPAQALKEAPGALCDQAELLSSAASGNLIASADVLGAMMLDAAPYAEADSSHFPAAGQPVSLTNDTRESAAASDGVAAFSPAVADPAPSPPTQPPSLAHMYWLQRQVASSTMLNVDDVSVAVSLLSVRLAAAAVSAKEGASQPYEVVLCQANDRDETTCTYHSEIAQYLFRVAQAESSDPAAVDRLARVVIAVEEISFTRRTVTLGNQAKGNREGSRSQRRQAHLASFLCHESAVAVMDRYPNVVYLQTPLPNARERSFTPPRGSFAEGGPAPRVSRPLSRVVVCVPATSQDGVRPRGWLAGGEEEAVDADADLAPFEVGTSLSSRRSASSFVSGAPPNTFVERCQRASANFSKLQKQLYAAIRAVRADSGGWVIYATQSANVIENEAVVCAVLQRILKEGDGLSLSCESCRAEGEGAKGSAATARHARRAVSVECVPLDSPIMEACVACSEAASLLQLLCRQGRPGLSTWVAIEDGPVGQDAEQYSLELRTSVAQAAWRTDPMRTGSDGGFVVCLRVTPVPQSQEHQHGGGRSAAASVPPQSCCWWTHPDSHVVSAVTPATLQFVKDMERGYFARRGDASATAPRILHVGVPAGHVSTLSVAPAPDTNVVAAASALPVDCQISSAVCHVDVLAALRRSLPHLTLSTKALCELLLLKHVESRILRRQLRLHRRQLALQQRGQLNVEGSAIDMETETHGFLAAVEKAAENHLLSAPPSGKLSNRFYVWVGVAAESLLPSSRISSTPQTKESAESPPVAAGAALHPAVLAEVETAGVVAEVEYTHHSSSCDSASSVIDFTARLDVPSDMPERSKHLVALEEWRVALRDALLYVRRRTCKDSASVRLWADLFVDNADVSALKVGTGAANVRRSDKVLELAEEEYEAIDTAQTVPTRGAAYLPDLDDRPSLPGTEAGDRRADWLRDTNYLEWRRRRTQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1L4</accession>
    <name>A0A088S1L4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_040450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="AIN95371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703693.1">
        <property type="nucleotide sequence ID" value="XM_010705391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1L4"/>
    <dbReference type="GeneID" id="22572004"/>
    <dbReference type="KEGG" id="lpan:LPMP_040450"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040010800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_040450"/>
    <dbReference type="eggNOG" id="ENOG502S2K3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="246814at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="325" mass="34898" checksum="C701AFDAE75F0606" modified="2014-11-26" version="1">MAKSSRSKWKKMHRRQRAQAEAMNTVKRIRQLSKKLELTVKGGISAVPPQEPEKRFHFLNPELDSRVPNTRKHLNNNYRAELNHVQYDYTKPLKLAPPKTNMYGKTDVNAPHRMTVTYETIDADAPLAGHALTKADMERLARRQKQQESETSAEAACAEEDISKAEVNSDSCDSDDNGPEEYVIGMNDVAPHRASGKRKANAKKGKDFVAPKATMSTASASAGASSSVSVAGPSSRMLAIAAAAAMANEEGSDDRPCNGGVTAVNKISSMQTMRRKNGTVVSTGGASKMKKVGHLSGSSGTRVVSSGTKAAKKTGNAKHSTKSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1R2</accession>
    <name>A0A088S1R2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_350140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702954.1">
        <property type="nucleotide sequence ID" value="XM_010704652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1R2"/>
    <dbReference type="GeneID" id="22579043"/>
    <dbReference type="KEGG" id="lpan:LPMP_350140"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350006300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_350140"/>
    <dbReference type="eggNOG" id="KOG2137">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="79687at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF6">
        <property type="entry name" value="SCY1-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO02154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="641" mass="70740" checksum="DC6C62A8A4E42F6C" modified="2014-11-26" version="1">MFKQLKQTVASAISSNPLYEYVLDTSGTTLCGRNNLFEKCDAVVRASGKKVTIFTLRIKRMLECCSADEALAIIKTVKNSVALLTLMRHPGILSIDGQLVESKSKIWFVTERVSMVLTPETVHGLPLQVKLLGLCHCAEAIRFLHERAEILLFNFAFSSIYVAEDNKWKIGDLCFAMPRAQLNAPPPSPFPFHSVAAPLLDYLPTEYVDFCTKQSDTAHRDLFSAEAAPLVYPDSDTYGFLVVTVEALEEKRLFHCSGNPREQQRQLSSVEALMSRYFPAGALRLPRPPIATVISTGPFATPDMKTLTALLSFDILDNDTRFRLLKALYDGLTQSGFCEAVILSDIVPLMLRESKMDAMLRFALPILLLCAGTLCADNFSRALREYFVSLLTAIIRAPSLQRLAVYAEQLLQRRESIQKHFASVEDRATFIVPLIMKLMQSDGNERLQKGSLEWLRDVLIQTPTINLDLPNDIATRLLHVASSNADFFSLAFQCLEKILTLATTETKMEVEVSLTRDISNATLSLTTVQQDYILNLLKSIQEKMSPEHRAIRSIPLLCPLLLHTNGTMRQFAVASIVGYAQLFGSGPTPPLPSSGASVSSSAAHSAAPLALTAPLTRSTQSPSAAQPATRANDDVFASLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S267</accession>
    <name>A0A088S267_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_352070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703144.1">
        <property type="nucleotide sequence ID" value="XM_010704842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S267"/>
    <dbReference type="GeneID" id="22579236"/>
    <dbReference type="KEGG" id="lpan:LPMP_352070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350026700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_352070"/>
    <dbReference type="eggNOG" id="ENOG502SQ7A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264067at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO02344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="99" mass="11865" checksum="2ED37B838332DDAD" modified="2014-11-26" version="1">MVESVEVLQWRINHAIENQMIPPETNYISELLAASLALDNSNEQLRLLDYRWQAYLDKQYVQCQHLDEFLEGLVQHLLKKKPDRPLEELLLYLESERRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2F7</accession>
    <name>A0A088S2F7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase, putative</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_352690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703206.1">
        <property type="nucleotide sequence ID" value="XM_010704904.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22579298"/>
    <dbReference type="KEGG" id="lpan:LPMP_352690"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350034000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_352690"/>
    <dbReference type="eggNOG" id="KOG0615">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273310at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF30">
        <property type="entry name" value="PHOSPHORYLASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="2876"/>
            <end position="3419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="786"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="852"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="905"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1210"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2151"/>
            <end position="2202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2706"/>
            <end position="2731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2818"/>
            <end position="2850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2915"/>
            <end position="2936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3066"/>
            <end position="3093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="786"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="869"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="908"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2186"/>
            <end position="2196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2719"/>
            <end position="2728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2827"/>
            <end position="2838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="3071"/>
            <end position="3088"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO02406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="3426" mass="364141" checksum="91D20E356E871E30" modified="2014-11-26" version="1">MELRQLKPWPSKCATTTMKGSSPLRLRANSPTTTSTSPATTPAATAASMSVLYSVLLRTSVLRSSVVKNPAEHSLHSHSRADMDWSVREAVRTEVERLLPYRGVTFESAGVADSDKRTPAQSFLGSAAKGEKGERSGCCSSHVASTKAFCHASEPNGRNPHASVPSTTTSVAVTDAPSSLVTRETSSLVSQGLSFGPRVVIKRLPRRKARAAAAAAPAPTASKLDSTEAPEHLSASPFADNCNRGDCVTREEEASSCTAPSDITGNTRSSTVVLAAQLPDIQRHLDRLFDDFSAAVEQCRVTLDQQQLQSGSLALWKTAREKRNASPDEPSASWPRAEVSSSRHPQPPPHTTPTCHRRDNPTIPVTDVLPCHNSHRPVSDLPSPDYILDEQGHSQGTATAANENGCAFYTLSPSTESSRIVDGSAEQITPSLEIEDLPRGIVIIAHAIAEHLNAILHPTPEVAALGEEAVAALPDQSRGGRGGSSELTALLAVPTTACRGSHAGRTGESRGPASPVSFAFPSTSPASCPNRVFQSLPGSSLTSPALRELQQLVHNRLWLRITTFLSSVSLNTPGDDCSMPQPTAPVGQREACAYAQLPFWIWLYAACGLATDVIHAQQEAQSALVTPGKVEKLRQRLIPPSSTTTVQPSLSLSQLLPMVETLARQLQRREYERVQPMAETLLTANTFLSFAGVQMTDRAVMKRLFPLQSSAADSDALGFAALLPHSARRTTHGTSVTTESSSGNAIAGIFDAAATPSPINIMSPNRLISADHAMSAFVITEPIVDRSSSGGSVARGSSLRRGQGANGDIGNMAASATGEEAQQMYSGRYSCPSTVELYLQWLESADSTGFSAFVPPSEAEQSPDRAGAEAHTAGETAASLRDSPPPCRSDTIAYTQVNASLMAEEGQFDDRNGSIAREDSSRGKGRSSSNGSSICATQQRASELFQVAAVMPSADLAPCLRRAEKELYQARSAVQFARKLGTLYATQDMNTLLPLLPAVARGEPMSPNFNLFSARSDGGPMEGLGGTLPPRGSTDGTGTPASPEALAGGVYLQSTWTGTPTTSNPMTGGLPSLVVPPSQAVTDRVSGRHDPFSFHRVIAEATSPTLFPSVTSPSMEQRFLMEHLNSCAAAIAPSSDQLFLDTTRALEVAFSLAVVLLSHVMGEAAPKRQAACGERTAPVASTGDSSASAVSTKTKTATVTAVVVKQHPSKVAAAAPSDKSEGNAATTTMAAPPPPRPLSMDLANVFGFGSSGFRWQHLSAYVRETLISVALRTLQRKDAVMTQELLQYIALDTAIAHHYAQVRRHHPVPTLELAKGAGRALKKSCDISKAAGPQVTDFSMSPPESPANFVNVWFSSFANLADTTTHLLQSDHRTPSSLKGAVWHLAGLAQYFLVTRARGYAMYGGQSHLCPTTLSGCGSGNAVGIDVRTSLVPSSAALQSFIASQLVDPAGRVFGVIVSFMDSVCQALSVEIESGGAAGRQYSEGVMFTGDSSDDESSLMCPTMDGSVYLGSAGESASLCSSDGGAYGMASNRPEIFDFQACWMELAIHYFFEIVDVLLDAALHLPQKPLYLYQLIVSASYMAGPSGDFTDSLAIAGLAGGGGSPPLWGHSDLSVSVVLTAPQVVADSPLGRVQEFLSMYTSMVLQSAVTHFTVDGRLAQSQTDTTLGTPLNTAKAAGGVSEDNSSHIFWERLLSSLAASAHSAALGEVPPAMWQPPLSAWTPSSAAAANAAVCSEAPGDISYMQNTMWWPNTRFQRYSHLIRIVEHAQLVSLYMSSSAGNDPAPTAPILSHLEAPRAPRDGALMLQVNPITALLNTSTGPCAQLLSISYACPPLAVVTSGSSLVPGSARTTLRERHWFSCSGSPVDQLPGRFPPIANRRVLTDRVMREVCGGLWIRVEVLRLLRIAAAPMDVTTFASFTTAATDVAVQVQDKTMQTHYKAIASMKAGTESVLPKTYASTYVRLLFLRYVQAFYTDMQALSASGPTTAPDHTPRERVECLSNMISHVSSRGDSTPCRTLGSPLMRSPATPFQHLTQRLWMHYCHHLLWVLRELCWSCAEAHETAANLSVASVFGRLLQMISGRGELEEDEEIDGCDNESVEGLLDAQYRSSKSVGMSVITFNRSVAPYSAVEGSGMEGFVDFELSSPDSSVTVVPELSEGCKRPPRPQQDSPSSVDSERRREPSWNALQSPVSDASTKAEGVAVNTSDLASVRDLSERRRLGLNPHSITGGGEAAMGSVTPLAISSTSVPAPPRSPVTGPPVVLQLPLTGLKPPLYFTSSGDTAAAQENDFYKEQSKQRQISGETAERFLNSTSVSVVDVATYTSHDHEDEDDGECNVEYEACFGTQVSRFKHTLPRSDSPESCVSCTTASANTHSASSGDVPKPPALTVPKLSLRALSPPLYFTSTGDTGVFAERTMSTSLLGPQAPMFPPSQPTPGAPAASETAKVSTLLPQSPLPVPVLLTSTPTTVGGVALPKLSFSSLNPPMYFTSTGDTGGFVEAQNQKPQTATGADAITQFHADPTCLHAGLAAQGTACGGKVDTASASVAAATVSNGPSAATAAAHLDERLSSDELNPGFIFSDFAGFAPTGGNASGGRNDSDECRGCADCVGKQNAKERCAARRHGGCGLSLNSSTVPEVDSLSLRTDQRRRRRVPRTSRSVLAPIVAPAVTMELILSICSIILQQDSGMIQYVYTVSSLTQKRVLPGMSSSSQRRRHTGSSSAGAASGVTFTQKPDAAQTDRWWYTPQHSPSSFHVIQAMHNYLKDSRNSLVIDLLEEWVLLEYAAAERARMEWYESVYASSREQECSQQLPHFSFSHSASSGSTSNAMHPSYLNQRHTGTTGGSRSGKPSTAMLAGRYVLLRLLLPRAITPLVTVQNERRIGSGGYGFVTSGFVQEFGPGCNMQLPPGWGQCGSRWKPAETRGSAAASGSGAGGGVATPSSLCTGWSFATTAERVAPGVLDGLRVPWRTAVQRIAQAVCRYEVAIKHVPLNVQGSESGNLPLCHAEVLAMYRLRGHPHIIPLLSFDNTKDEYILVLPYYTQGSLRLWRQKHYPLGCAVFTLPPGMKNSRRSGSTSTTSPTRASSTPTQGAAPSTSLFATCARCLLQVLKAVAFMHDHHIRHGDIKCDNILIASADASAERGEMDPPTLPSSVQLCDFGSCDTCDDDDMQNLKHDIMAGEARFLAGRWGVGRGTEAIQPPELMSAKRRYGLLRRIMKAVAPAATATPATSSYFALSERTDRGANTGGFTGASAENLPLRGRGGEVMEPAGRQVTELLRRAELSVDIWACGCLLYEMLTGRMLFGEARLGRLLVLAAVDDGEEQGPKAATSKANAAAATLPALRFPLQKVATAAKASVGGDADLSFTPSVSRKALDDWEWRDLEAAVGKRVVDFMSSLLDLDPLQRPSAYEALNYWKAIMVEAGLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2G8</accession>
    <name>A0A088S2G8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_341140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702540.1">
        <property type="nucleotide sequence ID" value="XM_010704238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2G8"/>
    <dbReference type="GeneID" id="22578619"/>
    <dbReference type="KEGG" id="lpan:LPMP_341140"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340017300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_341140"/>
    <dbReference type="eggNOG" id="ENOG502S8E9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="238503at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="354" mass="39013" checksum="DB584CD852D5A462" modified="2014-11-26" version="1">MQELARQFEQQGIRCSGDAPQRLWCSFCTTYQQDLAKFSVPHSELEEGASVKAEEKTGVADETARDDSSSGPSPSTSGTTRDSHPSTPSSPLCILEATKESVLAHCATRTHLYLYEYYVQNELQHWCAVELHGYRMLLSHHCVYPSRMFGDGRLLMDTSISGGMLLGVDICGGVKLWPQHQYTVVELILPSARSGVREVLVPPLSVSCDEEENQRANEAESGKQRASSPPPPSPPGSRVVRVIHEASEIPAEVASTYNSNLSESRRRGSKATRFLDRGPTGASGGRVSSSIVPRYFDEFHRLRSQRVMEGSLKTVLEATNASIIGEARLRRQRRRYAVKHNHVSLAKEKTASGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2T9</accession>
    <name>A0A088S2T9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cysteine desulfurase</fullName>
            <ecNumber evidence="3">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_342690</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="3"/>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702695.1">
        <property type="nucleotide sequence ID" value="XM_010704393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2T9"/>
    <dbReference type="GeneID" id="22578774"/>
    <dbReference type="KEGG" id="lpan:LPMP_342690"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340033000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_342690"/>
    <dbReference type="eggNOG" id="KOG1549">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250117at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601">
        <property type="entry name" value="CYSTEINE DESULFURYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="10">
        <location>
            <begin position="25"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class V" evidence="10">
        <location>
            <begin position="155"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIO01895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="456" mass="48616" checksum="A0397D7B387B741F" modified="2014-11-26" version="1">MCNAPGPPLKKRKPQPLPQTEPLPIYLDYNATTPLCEEAWQEICRIHGTWGNPSSAHPYGLAAKYELEEARKKVQVALNALSSESIIFTSGGTESNNLAIAGGTLALRQREPRRRYVVSSNVEHPAVAEVLRYMNGSNPATSGTASTTDGAKTGSQATVKVVHVAVNPQTGRLDASSLRKVLNGLPGGPTCVALVSVMFANNEIGAVNDIKELCRLTKELCGAACLFHTDAAQSLGKVPVDVQDTNVDFLSVCGHKFYGPKGVGALYVKPGVAVQNILFGAGHERGIRPGTENVLLVAGIAEALRIACTNIDRFSAVMRDTRDELLRVLKVELATHDMGLVVNGDVTVALPNTLNCALFKRVPNMKTGSPVTYISAQRLILATGDEVCISTGSACHSTIDEGTEIVVSDPLKAVQVGVDRAIGTLRISTGRTTTMDDVRRAGKIIARRAAQQFEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2Y4</accession>
    <name>A0A088S2Y4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Immunodominant antigen</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_354380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703371.1">
        <property type="nucleotide sequence ID" value="XM_010705069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2Y4"/>
    <dbReference type="GeneID" id="22579466"/>
    <dbReference type="KEGG" id="lpan:LPMP_354380"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350052000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_354380"/>
    <dbReference type="eggNOG" id="ENOG502QSYJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47026:SF2">
        <property type="entry name" value="FLAGELLAR ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47026">
        <property type="entry name" value="PIGMENTOSA GTPASE REGULATOR-LIKE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="49509" checksum="FD8194F90602226B" modified="2014-11-26" version="1">MDSIFTRPAVADPPQSLAASHDSTPAFMSVLEPYKRSGQRPPMASSGATQQQRFQQPLHTGKNKATTSALTASSYVLPHGAGAVARGDQNRKTDGALCGMHNSYASIPAAPLDRPCDEEFDAVERRARMALEHIAIRDEGLEANIGDHIEVLQSYRASCEARAMYREAYLVQQVLQNLRLEEESRHVRGITEQQMEERRMLEEAHRQEFREFHHSWNARIDAFEEEQLEAELALLERQNEELIGFQEEMRNFQPRLIKYSRTLLESRLKQQTLAKQRDYVGAQAQKVHAEALEVADMERFEAARTSLFERREYTSRHRHQQELYALRTKMESRRLYLERYRKQELDVLLQRYINVRRSMESQQNIVRNKTGTLLLKHACNRKTDNSGTAVLVESAGSGTFGTVVQRRQAQELRALPSQQDGAYTAGHKGDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S346</accession>
    <name>A0A088S346_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein kinase A catalytic subunit isoform 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_343880</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702810.1">
        <property type="nucleotide sequence ID" value="XM_010704508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S346"/>
    <dbReference type="GeneID" id="22578893"/>
    <dbReference type="KEGG" id="lpan:LPMP_343880"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340046100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_343880"/>
    <dbReference type="eggNOG" id="KOG0616">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05580">
        <property type="entry name" value="STKc_PKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF67">
        <property type="entry name" value="PROTEIN KINASE A CATALYTIC SUBUNIT ISOFORM 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="63"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="11">
        <location>
            <begin position="318"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIO02010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="372" mass="42241" checksum="B5E15BBDFE998FA1" modified="2014-11-26" version="1">MSSAAMDKGAAPALILPKREEKSKSPTNVSNPLDPSKPAIATNAKSAYLFEKPDTSYWALSDFEMKNTLGTGSFGRVRIAHRKGTDEYYAIKCLKKREVIKMKQQQHLAQEKGILMEVSHPFIVNMMCSFQDEKKVYFVLEFVMGGEMFTHLRTAGRFPNDVAKFYHAELVLAFEYLHSLDVIYRDLKPENLLLDNKGHVKVTDFGFAKKVPDRTFTLCGTPEYLAPEVIQSKGHGKAVDWWTMGVLLYEFIAGYPPFYDDTPFRIYEKILAGRLKFPNWFDGRARDLVKGLLQTDHTKRLGTLKGGPADVKNHPYFHGANWDKLYARYYPAPIPVRVKSPGDTSNFEKYPDSPVDRTPALTSAQQAEFKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S348</accession>
    <name>A0A088S348_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1</fullName>
            <ecNumber evidence="1 11">2.1.1.57</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 11">Cap1 2'O-ribose methyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LPMP_356850</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside) in mRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67020"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="Rhea" id="RHEA-COMP:17168"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167609"/>
            <dbReference type="EC" id="2.1.1.57"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.57" evidence="1 11"/>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703613.1">
        <property type="nucleotide sequence ID" value="XM_010705311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S348"/>
    <dbReference type="GeneID" id="22579713"/>
    <dbReference type="KEGG" id="lpan:LPMP_356850"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350078200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_356850"/>
    <dbReference type="eggNOG" id="KOG3673">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251234at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004483">
        <property type="term" value="F:methyltransferase cap1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016556">
        <property type="term" value="P:mRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12760:FF:000005">
        <property type="entry name" value="Methyltransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050851">
        <property type="entry name" value="mRNA_Cap_2O-Ribose_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025816">
        <property type="entry name" value="RrmJ-type_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16121:SF0">
        <property type="entry name" value="CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16121">
        <property type="entry name" value="CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51613">
        <property type="entry name" value="SAM_MT_RRMJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 11 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 11" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="4 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RrmJ-type SAM-dependent 2'-O-MTase" evidence="13">
        <location>
            <begin position="85"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="371"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIO02813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="398" mass="45116" checksum="A9D69983EC814407" modified="2014-11-26" version="1">MRTVEDRSLEFLIRRDREAELPPLASLCCNYFKQRHWRDAFDDEQASLREELWAVKTQLDTIPMEAYTATRNKLFPLALSGEQQQFSNRAGHKLLESMESTGVWMELSKLLCGKSRKRPRDFAFADVCGGPGAFSQALFKAGRKQGWRHLHGYGMTLAGVSGLDWYNPLLNSPQFTCTYGLDGTGDIFKLSNIDCLVSITKAAPMFLVVADGGFSVDFSVANYQETISSRIMYGQWLAALKLLRKGGCCVLKLFDTFSPLSRAVVYLSCFLYSRVHVAKPRHSRVVNSERYLVCVDFLGYPNEAWGRYLDCFYELGFVDNEHVPELMPREWCLQDEIFMADMRDMNMTVATNQMTALQMILNAASAVEEELKAKETTTRTPAESDDSPLSSRESCKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S353</accession>
    <name>A0A088S353_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_356950</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703623.1">
        <property type="nucleotide sequence ID" value="XM_010705321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S353"/>
    <dbReference type="GeneID" id="22579723"/>
    <dbReference type="KEGG" id="lpan:LPMP_356950"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350079300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_356950"/>
    <dbReference type="eggNOG" id="KOG1061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000113">
        <property type="entry name" value="Beta-adaptin-like protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="8">
        <location>
            <begin position="33"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="609"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="609"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIO02823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="746" mass="82847" checksum="EAA962396D677B86" modified="2014-11-26" version="1">MENFLRKARERIQRKLEATKMGSKYFAQTRRGEIAELHNDLNGTDSYRKKAAVKRIIANMTMGRDVSYLFVDVVKLAPSTDLELKKLVYLYVLSTARLQPEKALLAVNTFLQDTTNSSPIVRALAVRTMMCIRVASVLEYTLEPLRRAVADPDPYVRKTAAMGLGKLFHDDMRLFYQLDFKKDLVELLNDNNPMVASNAAAIVCEVNDYGSEKIESNSEWVNRLVYHLPECNEWGQQYILELLAAQRPCDKESAETLLTRVLPRMSHQNPAVVMGAIKVVANLASRCSPELIERCTVRVNTALLTLVKRDAETQYIVCRDIHALLVIFPNLLRTNLDVIYVRYSDPPFVKLEKLRLLLKLTTPSAAPEIVKEFAEYASGVDMVFVVEVVRAIALLAIKVDTVAPDCANLLLQIVDRRPELLPDVVTAAKDIVRKYPELLMLDTLVADYGADDVAGEEAKVSLLWMLGEYCDFIGNGKDIIQRFIETIMEHEQRVQLSILSAAVKMFLREPQTMEPQLNHLLEMVTKHSDDVDVRDRAFAYWRLLSKSITVEQMRKVVHGQVVPVNVDRTFSDAMTMADLKKSLNTAAIVFARPYQSFLPPYGLAGVEFDEEDTEDDDAAELPPTPPMGTQDGSPAPSAAQGGNDMFEFAGDGTGARHQVASGNNGAQHADPLDVLFSVLPPPVAGSSPAFQAAPGLHAPPSPPTATRTIEDLLANSMERGRQATLGQISAAPQPIDRGTQLNDILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3B3</accession>
    <name>A0A088S3B3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_090650</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN95981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704303.1">
        <property type="nucleotide sequence ID" value="XM_010706001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3B3"/>
    <dbReference type="GeneID" id="22572635"/>
    <dbReference type="KEGG" id="lpan:LPMP_090650"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090011700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_090650"/>
    <dbReference type="eggNOG" id="KOG1312">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5977743at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF458">
        <property type="entry name" value="PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="9">
        <location>
            <begin position="245"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="149"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN95981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="500" mass="56909" checksum="3D876FDD10A5DD6D" modified="2014-11-26" version="1">MLIFMFGAFIGAIALVGTLMYIIIMGPSRYHRDGVVGKLHRLLTSVPLNVCGLCVSCLFGCNQRKGRLCCSRCVKHTLHERNWFMVIFYIALVWTVEALYLLVSLPRLKASIVSKTVSWGLVALSELLWVCATFTDPGTVTAEAEMEAQRRQFSTRPATDSKKRLLPRKQAKRGVGIPGQGTTPVNPKAHRPFLFSPAEEFVLNHRYVVDGMVYAMAPDEVTAQRTAAQKEYVSPAVGQRVHLGQNCITCHVPRPSRSKHCRLCHRCVRRYDHHCPWINNDVAEQTMRHFLGFLLCHAISCTWACLDLFRCIRQFLMAHHAWGWVLRYPNGHTVSLSLSQYAVILINFHMLEACLFFFAVFIGLVLYGFWGYQMTFAMANLTVNDLNKIDDTVEFVVTLPTLDLVYREARKVRERLEQVAERKPKALLALTEPPPPKTEPGYEEGREKNQAYRKRVKKMLASDLKGLYDRGVWLNLMEILFPSAPLRDSAVLAKAMVYVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S403</accession>
    <name>A0A088S403_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="3 7">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_100810</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3 7"/>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696804.1">
        <property type="nucleotide sequence ID" value="XM_010698502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S403"/>
    <dbReference type="GeneID" id="22572818"/>
    <dbReference type="KEGG" id="lpan:LPMP_100810"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100014600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_100810"/>
    <dbReference type="eggNOG" id="KOG0549">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000045">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811:SF19">
        <property type="entry name" value="39 KDA FK506-BINDING NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811">
        <property type="entry name" value="FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="8">
        <location>
            <begin position="45"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN96151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="155" mass="16616" checksum="4379C04AC7529DEB" modified="2014-11-26" version="1">MNAADQAFMASVDATPNVHKLPSGMRFKILTKVSDTASVKSPNVSDPCSVHYHGSLTNGKVFDSSMDRSRPATFAPNQVIKGWTEALQYMVEGEEWEVYLPPELAYGSRGAGGAIPPNAALVFKIHLLKVMQGGKPGADGHKKLEQALSISYAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S4C7</accession>
    <name>A0A088S4C7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_353430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703280.1">
        <property type="nucleotide sequence ID" value="XM_010704978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S4C7"/>
    <dbReference type="GeneID" id="22579372"/>
    <dbReference type="KEGG" id="lpan:LPMP_353430"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350042200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_353430"/>
    <dbReference type="eggNOG" id="ENOG502RZ0S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269592at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO02480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="195" mass="22296" checksum="F265C0AC8D17DE63" modified="2014-11-26" version="1">MLRFTQALLRVQSHQKKRAQHPNAGTRYGRVYNRGFVRYGFGGFGMSVYTPKKDRTFKVMPVPPSPPATTAAEQRDDFADNRGLVATTRTLSPTFRMFALEDGGVLVSHPSHAQVMRWNQRVHTEEGKATNRTTMDEYVNSRIQAIIADNTIENTSLSQWRKAHMWNVIKSHGRLQRRWGTPDFITGARSTLYNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S4J2</accession>
    <name>A0A088S4J2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rnh202 triple barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_120730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009381">
        <property type="protein sequence ID" value="AIN96401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697054.1">
        <property type="nucleotide sequence ID" value="XM_010698752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S4J2"/>
    <dbReference type="GeneID" id="22573079"/>
    <dbReference type="KEGG" id="lpan:LPMP_120730"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_120012000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_120730"/>
    <dbReference type="eggNOG" id="ENOG502SNGS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267189at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040456">
        <property type="entry name" value="RNase_H2_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13383">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13383:SF11">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="667" mass="69918" checksum="47D991D31D4F1E4F" modified="2014-11-26" version="1">MSQPPRSSDGYPATAEKGVTRPAMSLTCAAPLAILPAPSLEGETYWDHVGCKADLDSNDDGSRGDYNVNARDDSDSDDAEDGDYASASSLRAHAYNTASSKDGLCLFRSPTNRGLPVQYDPHDHTRPDLAHTPSSSLSAKVQQRRLWILPRDAFHPQCWASLTSTRSSLDTAAKSCSDGEAYASNGRSGACASTHGLVAPAAPVTTGDPHALPPSALQPDSSAVGAAPLALNCMINASVARLPHPRHGQPLLCLVVRDPTIPVVTRTFPPNLPSTVPASPSLLYEVQAHAPPSGFAQSWFVKEQVVPSTVGAGELLVATPLDLTFFALYELLGDAQRYERLSRTFMSAEDLYRDRDLRPSAVTSASAAGYEGDAPETNAFLTVFSGVGGGGEDSRSSTSPSAPFAAALLSSSGTHDASVDDGGPHGWAAHPPSQLTTSSFFSATPQGKLGGGSGRGWAGWARAAAAHPLLLHHCLRVLQSDGVLRRLCEVRVIGGNSYVQTSTSDAPVESLDAVYYRPSESVAVEWLKTRVERVRASPVLRAILQLPESSPVATATAATPAEACVEVPMTVAFGVVAEYVPDRLHAALAAACDLPDPAATPVSSPIAAASTDGAKRHRDDVATNRRKVEATPSAAGTKSASVKRLERAGKPKGTPTLLEMFAKKARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S4R9</accession>
    <name>A0A088S4R9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_130720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697154.1">
        <property type="nucleotide sequence ID" value="XM_010698852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S4R9"/>
    <dbReference type="GeneID" id="22573182"/>
    <dbReference type="KEGG" id="lpan:LPMP_130720"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130011500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_130720"/>
    <dbReference type="eggNOG" id="ENOG502RUMV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273240at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="158"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="591"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1253" mass="134918" checksum="383722E93BC85D7D" modified="2014-11-26" version="1">MSRVLAKGDGGEHHHHSTGEWVYVNNMNTLHATVSLPERMPYSLCERNMEAPGSSTTGYVGSRVGSTNTPHGKLQQSPQTQRAFADSQSTAEQQRGAIPLTASGEPVHANLQGVYNRIMRQLQRQMNYAELSRASLADQYGIDLQLACEQDHQDLKAAEVGRQRGTKHRSRTSSLRQPTSTATSPIKPVPDDSETDTASRPTSCLFTGYHVSPATIKVPEYAAPRPRGDIPTTACAGGGNGSRIASRLIQFKQTDTRSRASDTAGGIVVPAATNVSDVPGSGEPAAGTEGDDELVRDIEAQPCPLPLRLVIQNVLGTLQKKLSLAEGGSLKDCIVFAFESRALLDRLLKEIPLYSQYSAIRGTAGVATTTAVTAAAQQDIAQVYQELRKKPVLLPRADYVEDPVTGAIRGQILGGSTLQRESARASGAIAAPAAAVSLPAIVNSSRDFNTGDAVPPGAFTGGTGALADVQLPSGYGKSSRLHDATPQGGAATAAGAGCVGRQTQRHQVLRDHMTRGSAAGCQNLPSVSEATAAQSSVPVTMEAAGSYSIFVGASAAPPSSAFAAAHRATRLVSVGTVTEANNLTTVSKADYAALHERMEMLEAQLADAQMHRTALTDQLCEEAQYTDQKRRVLQYLRETLVRECAMLRSQLRLASSRVQLLQQHSQHQPLRGAGAFSAANEAHIEVPNTSVTVGGSTHMHKQLGASTALPMALSMSGDWHGSQHRSHSQWPSAQQLNMSGTIGSGYGGISGSGRRRLLAKQRHRNGSSVSPGASLSAIPPAVGSPAAGISAVVVSSCGVAGTVADGQQPNDLEAVQSLLDLVLLAVEEDAVIPSHALQMLRSGHADADLVKSRFRKDAKQQIDALRSEHDERQHALKKSMAMRTAEHKYLIAEQKHEVERLRALTDTTRVHAILQQHISDLRTELHKLRMYVAEQLHFFKTIMQNTAQSLLRRSALVDKTLSENVNLTTLINATREVIESAAALLTPMLTNEYRCGYHPWPLKLRNTTDPLAHVIQLRYGPSEVIHLRDSLSIFGQLYGALHRYILRQIVLPDYTRPSAGRPLQYLCAALALNPMSHTEVIFAARHAYDAEMQLCKRLARLNFRLMWNAHMQRVYTNRSVTALMEAGLNPHLSALPVAGRVNNLAKELAALLQARVAMQRERAENAKGTYRLWKEKEIDIMEGYPTPQTQRNRLALLSDGASGCSNTVVVGIGGNVLDGMMQGQRNTGSLGNFSKTFGQASMARSEGPRAATM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S4V4</accession>
    <name>A0A088S4V4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_131080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697189.1">
        <property type="nucleotide sequence ID" value="XM_010698887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S4V4"/>
    <dbReference type="GeneID" id="22573218"/>
    <dbReference type="KEGG" id="lpan:LPMP_131080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130015400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_131080"/>
    <dbReference type="eggNOG" id="ENOG502QUU1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269713at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="185" mass="21382" checksum="AEA90EB9D7F88ABD" modified="2014-11-26" version="1">MLRITPSCCASKVTAGNARNQAGSPRRKAKIFHVIPGTPVTPVEKLKEQRRRFGQDRYSRQPEYRPGRNVRMDPNSFTLYATTKGVMTIRTSRINPSYKWLDVEPDIQKVFRSRCMRAALQARGKASMMVGDNVNYRAELDHVTEPQWRERVMQVSKATERFQDPNCFTRGLVPALRPLSRYSYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S511</accession>
    <name>A0A088S511_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_140080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697244.1">
        <property type="nucleotide sequence ID" value="XM_010698942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S511"/>
    <dbReference type="GeneID" id="22573275"/>
    <dbReference type="KEGG" id="lpan:LPMP_140080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140005600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_140080"/>
    <dbReference type="eggNOG" id="ENOG502R0VX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275654at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059119">
        <property type="entry name" value="NTF2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26532">
        <property type="entry name" value="NTF2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN96591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="343" mass="40166" checksum="4922124619F13486" modified="2014-11-26" version="1">MSTATNSTHRYNSFQLSFLPMSLLPKERSCPSSLGLSRLLHAHTHASANRCNRHTLTYHLTRNPTMLRQFAMPVRRAAQMAGVAAPPLLGVQQCFMNMNRSVQTRWEIDSQTASQKRTDYDFDKEQWMKQMRFASMDCIMDPDITPIRYTSFAGVKKAFRRFVTMRKLMDRRPDFDPAQLKELFIQFKTLSYEKSPDCFKTLQRITTHGEADRILKEIRGRMNEDFAKKSWRSLKQQGSKSTYEIEVDSFNLVTCYMGQMSQDDWLQITYRCEFRQRAGKEYDWETLIEYPVFEVRLGDGVKTPNTHPFIVVGVLKKDGTRYGKDSQDAADLRKQFDRTGRWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S5M2</accession>
    <name>A0A088S5M2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Calmodulin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_150940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697469.1">
        <property type="nucleotide sequence ID" value="XM_010699167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S5M2"/>
    <dbReference type="GeneID" id="22573514"/>
    <dbReference type="KEGG" id="lpan:LPMP_150940"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150014500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_150940"/>
    <dbReference type="eggNOG" id="KOG0030">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000386">
        <property type="entry name" value="Calmodulin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="86"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="184" mass="20138" checksum="04D5D38F9BEBAE8E" modified="2014-11-26" version="1">MTAPAAAAAASPTPGTSSVPLEWSSTWNLFDERHTKLVSHIDLKHILRSLGRRYTEAEFNDLLRPLPDPASYDAFVKLMQQPYTGPTEDDLVTALRAFDVGDSGRLKLSELITLLTTLGEKMPEADVRQLLAEVPTDEKGRVRIDELATYLCTPVPTTTPDIMELKKQLEQVQSTAGASATKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S6V5</accession>
    <name>A0A088S6V5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Dolichyl-P-Man:GDP-ManGlcNAc2-PP-dolichyl beta-1,4-mannosyltransferase, putative</fullName>
            <ecNumber evidence="11">2.4.1.83</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_180900</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.83" evidence="11"/>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697924.1">
        <property type="nucleotide sequence ID" value="XM_010699622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S6V5"/>
    <dbReference type="GeneID" id="22573980"/>
    <dbReference type="KEGG" id="lpan:LPMP_180900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180011900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_180900"/>
    <dbReference type="eggNOG" id="KOG2941">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="614844at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026051">
        <property type="entry name" value="ALG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036">
        <property type="entry name" value="BETA1,4 MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036:SF0">
        <property type="entry name" value="CHITOBIOSYLDIPHOSPHODOLICHOL BETA-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="61"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN97271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="868" mass="94610" checksum="9167FB25751A8152" modified="2014-11-26" version="1">MFQYEDLMWLISFPLVCAIILWFSLDLAVLVRVGGGRRRRANARRAIERLIMSSPVLRASSVAQPTSRDSTPNIDCPSQRLSGSALPEHVGMSGNGSSSDNEEGHGEQHRASPPGITGSVTARTIPRHQQRVRQVVVPAALRIATRAVVRRAVVLVGGDFARSPRMQYHAASLARSGLFDEVLLVGLDHGNRLSEDLLMSGEPQPERFVTRDDSAAAKEMEHAVYDVQARLESPELRPGCGCIVSTRYLIAPPSPPEWLQTVFPLISLHWVVCTLYRLVTLTGLFIFQTMCTTATRINEHGQLLVTDLIFIQTPPAIPFVLLVKYFVCPLAFVYNMLLYYGVVVPAAWMNPGAMRDVRQQCRLQSLRFTSAAGRSADSRCRSLAILRRFSIPSLLGTRSWVFYPTIVVDWHNFGHTILEQNHRPTAAVQLYKLLEMHVCAGHVNVTVSQAMRRALECAYPWLRRQSAIAADAPLQHHGSTSVAASASSQAEEALSTAVVSPTAVIVLYDVAPSFFRPVQHSRCVRDVLARLLRRHRAADPLPSHASASTPAKGSGNSGAYTLVSKADLETVGWGISGPPAWVYADAAAESVAASALSTLAAAPATMATPSRRGIMVVGSTSWTEDDNYSVLIQALQRLDHRLRHEVSYGSGNGSSSGPVDLWVLITGKGTARQRFEDAVRAAKLSSHVVVSTYYAQSYQEYSLLLGAADVGLCLHFSSSGLDLPMKGADMIGVGLPVIAMQYPAIGELIGAVTRVLATQVVCLRNGAVNPQEASQVSSGYAKAVQPSLQECERGWSFRNDTDLAFLLSSFVGLPSTSESVRDGDSSPSRLSPTPLSVMKQRAYEARLHAHTWEENWRQVLLPVLKQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S6X6</accession>
    <name>A0A088S6X6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_181150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697949.1">
        <property type="nucleotide sequence ID" value="XM_010699647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S6X6"/>
    <dbReference type="GeneID" id="22574005"/>
    <dbReference type="KEGG" id="lpan:LPMP_181150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180014800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_181150"/>
    <dbReference type="eggNOG" id="KOG4265">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045194">
        <property type="entry name" value="MGRN1/RNF157-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22996">
        <property type="entry name" value="MAHOGUNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22996:SF3">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036836">
        <property type="entry name" value="RNase_bind_SBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="273"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN97296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="333" mass="36529" checksum="397A505761DEAB5E" modified="2014-11-26" version="1">MAPGQQAPSSMPPHLANQYDNNNTRQQSLPSGSANNTAPHQQSMSPQPQPNRNSNPTGNNGTATNGEDRGGVQEGQMVKMLATVEASTVSYVPATQVLTFYITSICDSLTYEIHTGVKEFVQEGIVLYRPNKPKMEPVKTEIRGPQENRRITLKLDVNSLEEKEKAFNKHYPKQMPCVIVLRYKTTELQKRDGDRDNNFEEEMQVEHTEHTCVDLAEKPKRRVISQTVTAGGSAYSVENLYGADNDGTTPATRSGGGAVMIGSTIEDDEDGLCVICLTNPKDTAVMPCRHMCMCKDCGEQLLKHKPVCPVCRAPISTLLHMPSLSNNTAAHTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S6Y8</accession>
    <name>A0A088S6Y8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_181300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697964.1">
        <property type="nucleotide sequence ID" value="XM_010699662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S6Y8"/>
    <dbReference type="GeneID" id="22574020"/>
    <dbReference type="KEGG" id="lpan:LPMP_181300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180013700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_181300"/>
    <dbReference type="eggNOG" id="ENOG502RZQR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="244144at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37562:SF5">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37562">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="418"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="510"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="418"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="510"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="250"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="339"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="578"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="255"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN97311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="747" mass="77023" checksum="7593FDA5DDCD2035" modified="2014-11-26" version="1">MHSTGKSMTLNSYYSCSGTVAAMPAPGFAVSSAVQSDHRSAVSSPAISVSSASNPPGSNSANFSKASSSYKSHFGDSSTGTVPLHSACATTDQKVISHGCSGGVPSRISLSGSAGVLAASFGFVGSPVSAPGSGVIGAVTDLHRNSSSTGNSSQTVSSTSVDKFTSPPSVVTAAWPTPDSAASGAACSGVAASEPVEPTYVARSVHDVGVLLQEFYSGSSSFSTSSVPSSLAQYGAHTSCLASHFTSPHLSKAGANSSSNPSATTPPAARTVDESALSETHRSTLISFSGNKANVGDGETRSPKVPSCGGPSTFCDSALSAKENSRADDAVVVLPKSPLQRLKQRQQRIGTAPRHPHANSCNYDPSADQLGPDSLPKSRNNSAGQETHVSVYDSDFEALLSIPASQVLHRPSSSLGVSRLVLCRKFTLENPTSCSKGDLCKFVHADIRKVSRCSIHVNYAWRNLSLCTYPRLPAGDEVTVLAPNERPPSEVISSERILVTRGSTNWREHTAPLSHCAHYYFNRMCNRGKRCNFIHAVHVDPNVQGDFKHAPAPRAVAPVVSKPPGSTALRAASGAQAVASEGHQSSAYHGGAVRRSPAAKQPPLLPPVLPSVANNAATAGGGIAYSFTPTIFAPPPHGCMTYPLLSPTLSPPTAMGVPQSPTSVGGGAPYVMLMNSACQQVGCNYVPATLMTPTSQQLGSTNGVFFIVPTAPGTGGSLTGSGAPINWPLYGDLDTTVWMPPSPSLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S929</accession>
    <name>A0A088S929_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_210510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698838.1">
        <property type="nucleotide sequence ID" value="XM_010700536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S929"/>
    <dbReference type="GeneID" id="22574873"/>
    <dbReference type="KEGG" id="lpan:LPMP_210510"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210009600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_210510"/>
    <dbReference type="eggNOG" id="ENOG502SDQY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="263797at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="455"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="92"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="514" mass="55431" checksum="E4A9EF25BCB1FC7E" modified="2014-11-26" version="1">MDQLSVDLNSLRELVLQHQHQQRLADDTHARTDAVAVPSAPNASASTPAAAATADKIRELQRELCTLTEQLHAEKATSAQLLLQQRCDAASLQELLDQAARADEQVADLTSQLAEWKRRCQTAEEAHAGCAGQYESVREQVECVQRRVAETQAQHAALTAIATEAQRLVSKLADDKAQLQDTLCSREEALLRLSGVELERDEACARVQAFEAQHTEWVAEVCAYQRYFDSAREEYVHGVRHVAAARQEHEALREALAQSEARCVQWEQLFIDFRTGACTGCAAARADVSMDEVAADFSGASSTVIAVGTTVENSPYSGSGSDASDRLVHPTSPFNVDFVPLLEAKVADLALRLCEAQARADAAEHTAEDLSRLSLADSTLLMHLKSLVCALRPQVDGVADHNAQLQARLLAAESFADALIRHVVRLGEAFADEASQRCWLTAASVRDSVATRMSTAATSSSSTGSGRGVDVVSSGSGGHGNETTLPPGPPLSVLTQSRRHRLRTTALGRCDGEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S991</accession>
    <name>A0A088S991_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_211060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698893.1">
        <property type="nucleotide sequence ID" value="XM_010700591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S991"/>
    <dbReference type="GeneID" id="22574928"/>
    <dbReference type="KEGG" id="lpan:LPMP_211060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210014600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_211060"/>
    <dbReference type="eggNOG" id="ENOG502SPNR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269968at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="108" mass="11506" checksum="5FB14FEDDD68B8FE" modified="2014-11-26" version="1">MSGLTRWCVSTVARVWEKTKSTVNLVYNVGDQLRIVYNTANSHDERKSDFDATVLRAGGFVAATVLCIVVDAQGGIPNTLRWLRALVVTENHTSGGAVDAAASTVAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SAR5</accession>
    <name>A0A088SAR5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_240930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699433.1">
        <property type="nucleotide sequence ID" value="XM_010701131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SAR5"/>
    <dbReference type="GeneID" id="22575502"/>
    <dbReference type="KEGG" id="lpan:LPMP_240930"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240015300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_240930"/>
    <dbReference type="eggNOG" id="ENOG502RXYX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27140at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="239"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="417" mass="45387" checksum="AAA4B17CDA9B3B4A" modified="2014-11-26" version="1">MDRSLLFSPLGYSTNGVYIPSPVGGDTDVGGANDGRIFEELLDAEVAVNMEKLREASRMGIPPVHRGVVYRYLLGVAFTDKSIEMTMEEMQDKDFQLLNTAYTRMWGNGDENDDRGGAGGSGHGGSHGAGSSVAAQHTIRELLAFSMSSTAAVVSATEGSGPLHCSSGLRGVGSSGAGTVAIPFVHRGPSVVPAHAPSATLSAWEEGVTALRYCAPYNADARQWARMESALAALQMMYCNVSVDHVQLLMLLARQLDRVASSARDTFFTVHALFNALTKDGNILHDAQTLQVHCGNFLMLFRAVLLPLYEHFTVEGLTTWEWIPSLLTCFFVGRMHPDDVFALWDCYLADMSEHQAMALHPYACLAMLSSMTEVLIEAGKVELLYCLEHLPRLDTAVIMRKAVLIRESVYSKELLCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SBV0</accession>
    <name>A0A088SBV0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ras-like small GTPase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_260270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699848.1">
        <property type="nucleotide sequence ID" value="XM_010701546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SBV0"/>
    <dbReference type="GeneID" id="22575930"/>
    <dbReference type="KEGG" id="lpan:LPMP_260270"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260007500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_260270"/>
    <dbReference type="eggNOG" id="KOG1191">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8954335at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003526">
        <property type="entry name" value="GTPase Der"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032859">
        <property type="entry name" value="KH_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43834">
        <property type="entry name" value="GTPASE DER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43834:SF6">
        <property type="entry name" value="GTPASE DER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14714">
        <property type="entry name" value="KH_dom-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="3">
        <location>
            <begin position="2"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="G" evidence="3">
        <location>
            <begin position="194"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="GTPase Der C-terminal KH-domain-like" evidence="4">
        <location>
            <begin position="372"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN99141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="461" mass="52213" checksum="B02B5F7296D33ED0" modified="2014-11-26" version="1">MNSGKSSLFNLLCQDPTMPAKKNIVKDFNGITRDCVEAHAVLNDLHFTIIDTPGLVGGKLVEEAFRTVETADAAIFVTAVDEDVSTEEHDLIQYLAAKKLPACLLINKMDLVPEEDEALVLDVYNHLGLGNGIPFSARKREGLDMLSALLEPLYHIHAMRKVENDWDIEDLAMSGDEAAMEEIRDRNCTEQYIRVAIVGRTNSGKTSLVNRLLGYERNRAADATNTTRDPIEIPCAYKGKKLKLIDTAGLARQRYRTDREFLSCIHNLSLKEIRYAHVVIVVFDATEGHPNKYDMSILHTVAQEGRPFVLCANKWDAVLDQSATAEAIDFKIKRQVQEVKYSSAVVVSAHTGMNLTLLMDQVLELYDTWNKRVRRSELTKFWRKLEKSVILPYHVARVGRITQISTRPPTFLLQLQTKKEENQLPKALQEMMKNAITEEFGFRGVPLRIVQEVRDSNPDYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SCN9</accession>
    <name>A0A088SCN9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA exonuclease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_270920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700183.1">
        <property type="nucleotide sequence ID" value="XM_010701881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SCN9"/>
    <dbReference type="GeneID" id="22576270"/>
    <dbReference type="KEGG" id="lpan:LPMP_270920"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270016400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_270920"/>
    <dbReference type="eggNOG" id="KOG2044">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="372487at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF41">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xrn1 N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="592" mass="65290" checksum="86CD0339FC4758AF" modified="2014-11-26" version="1">MGVKGLWRYVEHHNIQYAYPSKNARADCYAVNPRHLLIDMNAVLHIAYNPKVPTTAATLRAVAAKMDELLTRVRPHDTLVLVYDGVAPIAKLKTQKERRHSLSIHPPRSATAPTTSKCSGSNSIRVSPWYTCDPVLDEVPLHREEILCGAEFVLACEEYITTYLQRRKAQYSWEKLMVSGCRESGEGEVKMSALLRRLWAATVADGSYDPDDTVSIVGNDSDLILVAMVAVPYAHYSLIDPFDLSLTSLWELMNHWSKAVPNPPLPAELLPSYRIDFVFLMLLSGDDYYDGIGSGSVALWQRYRHLRANEGYFRRSLIFGRHLEVDVELLRAVFARSGSMAAQLSRVSRNKRKTAKALLRGDRSGGGGGRAKEGAELLAAALWSLRSYVFGYCTDYGFVPHQEGPPSVGSLRAAVQVRGLSRKIGSVAAEGDANGETTDAGKVKEVLRPAKPIFSPLEQCVAVLGIRGRFSLELSRAIRASTEDDGHRLTTSTSIGLLTETVKNIIASVDTAQLTEAERRLSNCCRAGAEDDNEDVSAFMRLAALRPRKTAPAATQEEKQPNRAEEVQPTETEGSDGEDSDDKDETLALKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SDF8</accession>
    <name>A0A088SDF8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Haloacid dehalogenase-like hydrolase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_281430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700483.1">
        <property type="nucleotide sequence ID" value="XM_010702181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SDF8"/>
    <dbReference type="GeneID" id="22576588"/>
    <dbReference type="KEGG" id="lpan:LPMP_281430"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280020300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_281430"/>
    <dbReference type="eggNOG" id="ENOG502SI5W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27226at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47267">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47267:SF4">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE PHOSPHATASE YIGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN99776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="30578" checksum="D0A224464682DA40" modified="2014-11-26" version="1">MQRFFRERRQQLHPVPTTTGARTPIYIITSNGAVVHNAETGELVLEHALDPVVVREIYHLLPASEMRINTGIIQGDHWFYRRDWEEMLEFHKESGYRYQVLEFIPDSVDKSGIDTDTLVGSPSALSGCLKHVHKVFFSSWDLSLLEKLEQTLQQRYGSDLTVTFSASYNLDITAKDVTKAWALERLYEQMAPLPHETRSTATPEQRLKATVAFGDNLNDATMLSSAGRSFIMGNCNPKLRQRCPNLEVIQTNAEDAVARKLREIFHLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SGG9</accession>
    <name>A0A088SGG9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histone chaperone RTT106/FACT complex subunit SPT16-like middle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_320240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO00912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701712.1">
        <property type="nucleotide sequence ID" value="XM_010703410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SGG9"/>
    <dbReference type="GeneID" id="22577765"/>
    <dbReference type="KEGG" id="lpan:LPMP_320240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320007200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_320240"/>
    <dbReference type="eggNOG" id="KOG0526">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="498543at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000670">
        <property type="entry name" value="Histone chaperone Rttp106-like, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.150:FF:000007">
        <property type="entry name" value="Histone_chaperone_Rttp106-like_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050454">
        <property type="entry name" value="RTT106/SSRP1_HistChap/FACT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849:SF1">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="2">
        <location>
            <begin position="337"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="527" mass="58591" checksum="E64C54EDB5440B04" modified="2014-11-26" version="1">MWIPLENWGQLKLSAAKVEVKAEGGMEAGKSESVLELLALPKGKAKDNPNYVPHPILSIPISAISSASGTTKNDVSLTMRPAPTVGAGDLELTSIRFAVPNVCVGYEETEMAGKVILQDIQSGMVQYQEQFLQEHDSGNQDGKLLALAAMGSGQAKHTDEKVVATFDDVLLSYPSGKYKIVISNYNVVLEDKRKGASSGLLSFPLSDIQNLFLCDVPVYFSAAEEVDANSVPQYVVLILKNPLRIRTTAYNHVVISCPAGLTLDEEHPWRCELNTQDEIDKTLHLPPVKEGEVPSLVPTMSGRVSDILTRTFKAIAKVPAYGGINKEYKSVLTGHSQSSMRCFFHGSEGLLYVVNSGFLYLHRPATRILFNDVVRVELDESESGQATFQLTIFTAGARGEEKYVFSGIAKEEKDGLLRYLATKVKVVRTGLHAVSDDDDDEGDEEDEEEESDDSSDGDNGDDSGDDDDGYNDSRKRKREKQQHKKEKQHKEKKHKKEKRHKEKKHKKEKKHKKEKKHKTHRHEKSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SGY4</accession>
    <name>A0A088SGY4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_321870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701872.1">
        <property type="nucleotide sequence ID" value="XM_010703570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SGY4"/>
    <dbReference type="GeneID" id="22577928"/>
    <dbReference type="KEGG" id="lpan:LPMP_321870"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320024300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_321870"/>
    <dbReference type="eggNOG" id="ENOG502SFXE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="261478at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO01072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="177" mass="20347" checksum="DE5005392DE5613F" modified="2014-11-26" version="1">MHNLVNEAEAEYRQLSEKPHGPVVTELRTGDFDFLTSPEMPEIPIHIIETRREEQHRNGTVDRDTSLSEFIKTIGVDEADTEDPVNGYSVLHVKESTRAYFGEQVAYRLTRQNMIRYTEDTEWLKCMTFLDGQTADECERQRSVGRNAQMPSGGEVIVPVTTYRQAFFAKKSKKVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SHF1</accession>
    <name>A0A088SHF1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_323580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702042.1">
        <property type="nucleotide sequence ID" value="XM_010703740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SHF1"/>
    <dbReference type="GeneID" id="22578099"/>
    <dbReference type="KEGG" id="lpan:LPMP_323580"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320042400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_323580"/>
    <dbReference type="eggNOG" id="ENOG502RAWT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839412" description="AB hydrolase-1 domain-containing protein" evidence="2">
        <location>
            <begin position="28"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="559"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="605" mass="65767" checksum="FD3768784267522C" modified="2014-11-26" version="1">MAFSLPSRAAAAALLLILTILIDCVLCSSPATVAVDDDHLPNPSWSRTCTSPYEVCSTIEVYQYWEEKKNRLSFTVDALMKDPNEKGVLTVWMVMDDPDINVAKGIFREGINVVIVHPRGSRETPSFMTCANTSSPYNSQCWMSTACATELAAAAKAKDNPLNMSHYSADQAVHDLNWALRTLGDGRPNVVLGQGLSSMLAIRLLQYHSDTKAAVVLLDYAHPLVFDVYNYFGGGGMDAALQHILALCDDQAACVGRLGATEGSLNRLKAVMAMAKKGQLSCASRLKWTGGKGGGAAFAGELRAVLALMLRYPVYPFLASKADLLNLIPSLLYRVQRCNNKDVAALNKLFEYLSGARNYECPDSVALQMHWLVNDFLQAAPPANVDSFRSNAAARHLLLPPSSALSSFHAAAAKFPRLSRSAASQVLPVNATQQVLLLTADVDALLPGGAASQVAMAFRELGNSVQLRQLRGIVNQPAAALTPCLVNNLKMLKDRGVWADHAQCTINTAHRIDFINGATDVYYGTADAWDFDKPNTDETSGDRGDDDGGKRSLRNLWRIVARVLLVLILLVGISAGGYFAYHYLAANGIFRYSRVSDNFYDNLHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SI75</accession>
    <name>A0A088SI75_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_332360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702327.1">
        <property type="nucleotide sequence ID" value="XM_010704025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SI75"/>
    <dbReference type="GeneID" id="22578389"/>
    <dbReference type="KEGG" id="lpan:LPMP_332360"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330031300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_332360"/>
    <dbReference type="eggNOG" id="ENOG502RZK8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270654at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO01527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="302" mass="34271" checksum="CCF2BA7482FD241B" modified="2014-11-26" version="1">MNTRRKMVQAKPDIPSTQWHLMNEAFYPLFEADKRQPVEYWYNMAATGVQRDIFRRICSAIYQQDPATPDPIFDADFTETVELEEVRLLLKNYGAVLSDTVGKPKTRVWLLHCGKSNRDRNEFRSVFTGCQTTYERRSVMHTDYVAPDADSYPDNRTHFVRRVDWTSLKKREAMVGLEAERRTYGGVVGSQLDKLPVNSDGKPIQRITKPKNQFDGVNFLASLGFDGVPMEEAVAQLKAKQEAHLEAEWYYVDKDGSTVYKARSTKGPAVGATASKPEKVEGGILASVTPGPMTRWVNKTCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SL85</accession>
    <name>A0A088SL85_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_354340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703367.1">
        <property type="nucleotide sequence ID" value="XM_010705065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SL85"/>
    <dbReference type="GeneID" id="22579462"/>
    <dbReference type="KEGG" id="lpan:LPMP_354340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350051500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_354340"/>
    <dbReference type="eggNOG" id="ENOG502SAFH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273382at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38150">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38150:SF1">
        <property type="entry name" value="PFU DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="611" mass="66318" checksum="540891018B3D6A7D" modified="2014-11-26" version="1">MENACPFQPHINPRSRRLARYAPTLRERQEHDGQRRSASRGESHVQRQRGAPTPRPGTQAFIMDTENDVVERVWDLWHSVAIREAREPEAALVRGVHSVNSGDTLPQRRPRVVYVRTVLGMLNALGITSPQHDALITKFLTAMALEGGASEASRQDETVDAAQFIYVFSTVWRAAVTNPTRWAPTSAQVSVSSPVAQQRDSASSGATMHHPYAGSDSHRVAPPPRMKAVPASEPTAPEVDSSGSSASAGNALSASSCSVVWRSREGGKEEAHTDTESTSPSTNSDSGDERRVDVAESDADLLHTNVSHTSSTTLDSAEKPQAGVRGEERSPMTMEPPAVLDPSPEERNPGEPVITTPTHPSATSRTHHRSPFAAASCLCSTPVSHSRRTSSSFRAIPSDSHLLSSTASRELKRATKRVPGGLMRECTFKPAINSVCEQRPVSLSNTAIVQRRKPASIPLPTFQPNIQQLYQARDSLAWWTRQPFNHSDGNPAEAVVDPLTTSLETAVRRMIAARQRAQLPKPSLQKASCHSVPAAQSAVRAPVAHLAKPLLYVDVDLPHGRQERLALHAGDNIRDVAQRFSSLHGLTDSLCQRLVTALTAELRAIPMGKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4N1</accession>
    <name>A0AC62A4N1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pyruvate kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3420030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="XUY36762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="454" mass="49179" checksum="00145CF95C3BC069" modified="2026-01-28" version="1">MSVARMNFSHGSHEYHQTTINNVRQAAAELGVNIAIALDTKGPEIRTGLFVGGVAVMEKDATCYVTTDPAFSDKGTKDKFYIDYANLPKVVSPGGYIYIDDGILILQVQSHEDEQTLKCTVTNAHTISDRRGVNLPGCDVDLPAVSPKDCADLQFGVEQGVDIIFASFIRSAEQVVEVRKALGAKGGDIMVICKIENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEKVVVAQKILISKCNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNGVVQYMARICLEAQSAINEYVFFNSIKKLQPIPMSAEEAVCSSAVNSVYETKAKALVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNITQGVESVFFDTDRLGHDEGKEDRVATGVEFAKSRGFVQSGDSCVVVHADHKVKGYANQMRILLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4W1</accession>
    <name>A0AC62A4W1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase M20/M25/M40, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3320490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="XUY36757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="472" mass="51182" checksum="D9528480A5A26E51" modified="2026-01-28" version="1">MGDCDWTVIQKAVGAEWDASIIPALSAYIEVPNQSPDFDPHWATNGLMEKAFHILIDWVKGQNLLGLSYEFMEVEGRTPFLLVEIAGTERTNNTVLMYGHMDKQPPLRPWAEGLDPHKAVMRDGKLYGRGAADDGYAIFSAITSVSVLQRHGIPHGRVVVVIEACEESGSFDLDYYMAQCKERIGNVDLMVCLDSGSLNYDQLWLTTSLRGVTGGVLNVQTLTEAMHSGVAGGVVPDTFRIARELLDRVEDSKTGTVLLPEAHCEIPDHVAKSMVSMKSVPFKQQFAMADGVSAEPGDNVELALRNFWKPSLTVTGANLPEPQIAGNVIRTLTSLKLSLRLPPLVDSGKATQAMAKLLTTNPPYGAKVWFEPEVPGDGCATPELKPWLSNALNEGSKMAYGNPLAYQGMGGAIPFISTLTKMYPQAQFIVTGVLGPKSNAHGPNEFLHVGYAKGLTLAISHVVAAHFLLAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4W3</accession>
    <name>A0AC62A4W3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3520050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="XUY36837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="544" mass="60201" checksum="0712E2EAAFAA2BF9" modified="2026-01-28" version="1">MADAAAYLKLGKKIQCNRFGRAGVARVEATVIKGDGYATTAGNRGTAGVDATSSSSTSGLVVVQVNDAQREIQQLPMKRKRVAKRSRCDSDEEDPLAAPLAMSSVTVTDAPVTNICEPLSDVLATRDVTLDDGLNLANVASPTAPVPPVEGVAQRTNLMAKWFPAFLQERKLDAVVAPSMMFVEATVERVNKMREYVLILRYGIEDVESLLEETRQAQSIVWNKESTDCTSTHQRQRRECWDLTGKDVRALVRSVGLPRFTQALAEFSDVVFNSRLSAAAAVYSILSRRRRVGTPMDYNIKAWHEYLNTHGPQRGYAPRLSDLLWLSAASTSAMFTATASRLLRGARSCTKPTSVSDAAEDDRASYAESENDSRSSDRPRFFDNTENAAEEEEPVTTRIGWLSASVTFPPTLSPDQRALLSFLRFLMPTSHTSLERTSSAGYGVWLFAAFSALDIPLDPDTDRLAHDLFRTCCRHLRTLADWQGVSGSTRDLLLRKLHPRTQATAPPLYASLDDICREDVLALYTIVVVLARFFRQNQDHFIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4Y4</accession>
    <name>A0AC62A4Y4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase M20/M25/M40, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3320380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="XUY36746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="472" mass="51182" checksum="D9528480A5A26E51" modified="2026-01-28" version="1">MGDCDWTVIQKAVGAEWDASIIPALSAYIEVPNQSPDFDPHWATNGLMEKAFHILIDWVKGQNLLGLSYEFMEVEGRTPFLLVEIAGTERTNNTVLMYGHMDKQPPLRPWAEGLDPHKAVMRDGKLYGRGAADDGYAIFSAITSVSVLQRHGIPHGRVVVVIEACEESGSFDLDYYMAQCKERIGNVDLMVCLDSGSLNYDQLWLTTSLRGVTGGVLNVQTLTEAMHSGVAGGVVPDTFRIARELLDRVEDSKTGTVLLPEAHCEIPDHVAKSMVSMKSVPFKQQFAMADGVSAEPGDNVELALRNFWKPSLTVTGANLPEPQIAGNVIRTLTSLKLSLRLPPLVDSGKATQAMAKLLTTNPPYGAKVWFEPEVPGDGCATPELKPWLSNALNEGSKMAYGNPLAYQGMGGAIPFISTLTKMYPQAQFIVTGVLGPKSNAHGPNEFLHVGYAKGLTLAISHVVAAHFLLAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4Z2</accession>
    <name>A0AC62A4Z2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mitochondrial phosphate transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3420660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="XUY36829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="293" mass="31919" checksum="2F7CDA71234E6628" modified="2026-01-28" version="1">MKCIGGGILACGTTHTAVCPLDVVKCNMQVCPERFKSLAQGISLIMKEEGIGANGLLKGWLPTLCGYSAQGAFKFGLYEYFKDFYANMVGRENAKKYEGVIWLAGSASAEFFADMGLCPFEMVKVKVQTSPKGTFPTGMLAAMSAMRADPSSGFPYKSLAPLWGRQIPYTMAKFFFFEKVVRMFYEYVFTKPKEQYNKATQLSITFASGYIAGVICAIVSHPADTLVSARGKTSNAGKSYGQIAKEMGYMNVCTKGLGTRILMIGTLTGLQWWIYDTYKTTLGMGTSGGSGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5G7</accession>
    <name>A0AC62A5G7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Heat-shock protein hsp70, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2820120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="XUY36928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="654" mass="71302" checksum="17158A359508D667" modified="2026-01-28" version="1">MTFEGAIGIDLGTTYSCVGVWQNERVEIIANDQGNRTTPSYVAFTDSERLIGDAAKNQVAMNPHNTVFDAKRLIGRKYGDPVVQADMKHWPFKVKTKGDDKPVISVQYCNEEKIFTPEEISSMVLLKMKETAEAYLGKQVKKAVVTVPAYFNDSQRQATKDAGTIAGLEVLRIINEPTAAAIAYGLDKGDDGKERNVLIFDLGGGTFDVTLLTIDGGIFEVKATNGDTHLGGEDFDNRLVTFFTEEFKRKNKGKDLSSSHRALRRLRTACERAKRTLSSATQATIEIDALFDNVDFQANITRARFEELCGDLFRSTMQPVERVLQDAKMDKRSVHDVVLVGGSTRIPKVQSLVSDFFGGKELNKSINPDEAVAYGAAVQAFILTGGKSKQTEGLLLLDVTPLTLGIETAGGVMTALIKRNTTIPTKKSQIFSTYADNQPGVHIQVFEGERAMTKDCHLLGTFDLSGIPPAPRGVPQIEVTFDLDANGILNVSAEEKGTGKRNHITITNDKGRLSKDEIERMVNDASKYEQADKMQRERVEAKNGLENYAYSMKNTIADTNVSGKLEESDRTALNSAIDAALEWLNSNQEASKEEYEHRQKELESTCNPIMTKMYQSMGGGAGGMPGGMPDMSGMGAGAGPAAGASSGPKVEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5R1</accession>
    <name>A0AC62A5R1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tuzin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2020060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="596" mass="65632" checksum="6DD75912A273ED45" modified="2026-01-28" version="1">MLGPATRCCLLTAVRRSAFAQPGLEGLRIAAYAPAEPGVPPSPRRLPVAVGRVVAQLSPLVFAVDFRDSPPPPAVSLGSRVYVAYEREGAAPLPQQGGGVVDDAPGHGFLMGGFVVRVNLNGTLGVLLENNRVDLGIPPERIAVTEGVCKFVRHPGYLQVAEWVRSAGLSGADEVEGTACMLYHRGWRAERLHLLEASDTHCMAHLSQRSRMSLMEKAEWQRDHHRQMRSLYSERVKERDRRYMAAKYAGILSASVAFCGAFSLFGWNYRNHLTHQRTSQMRFAVRTLCKEAPPGASTTADAAHQLFRQTRREALERWIRPVFQQLDTAHPRIVVITGSFGCGKSSLCRAAMREDGMAGVVVDVRVREDPLRCVVMALGVPHVEACGDALDFISEACCRAKSMMGGKTPGIVLGLREADSLARVYGEALALACERRVCHVVVEVPLEALTVTSTLLPRLDFYTVPNFSRSQAHEYIQHRLDALDTEAFLDTVGTSRADLDELLAAAHQRRVSPAEYTSERLLRAMRQLQAAWGDDAQLKTAVKRLAQRPYGEGRHVGLDGSSLSHPSLRDVVLYNPVQDAWHFRSRVLHTAAACLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5R8</accession>
    <name>A0AC62A5R8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATG8/AUT7/APG8/PAZ2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ATG8B.1</name>
        <name evidence="1" type="ORF">LPMP_1920090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="XUY37130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="127" mass="12834" checksum="EF18415DD8E68F1D" modified="2026-01-28" version="1">MSAYQSSNTAEARRAECARLQAKYPGHVAMVVEAAKSSKAHLLALPRDATVAELEAAVRQALGISAAKVTLAVEGCTPAATAAVGDVADACKHADGFLYVSVRGEQPMGALLAGFAGPCFASDSGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A641</accession>
    <name>A0AC62A641_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amastin-like surface protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2020990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="194" mass="22191" checksum="6A5C0B5FCE518DDD" modified="2026-01-28" version="1">MEFNPFIIVYAAIQFIAFLLVVVGTALDMFRLQSRENFEDRPCITLWGLKPYCNSIVYSLSSDERFSLCPVRRKRFHMAQILAVVSVGVYGTAFALGVIMLYCCLHLRWVCLLLNIVGFVILPIPLALMVLSYKTDENSLCPKLRDDYDFGVGFYIFATAVGMDFIDIVFLLIPWQYDYLDVTCNSKEGNSQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6G2</accession>
    <name>A0AC62A6G2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Surface antigen-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0920250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="XUY37342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="161" mass="16280" checksum="A482CA54FD1AA5CB" modified="2026-01-28" version="1">MTSTRNKFLLALVALALLATYAAAVKGDCSVENCATCLEEDATQCAECNNGYRPTDAGQCEAISCDVPNCATCLEEDATQCAECNNGYRPTDAGQCEAIPCDVPNCATCAAGSTTQCAECNADYQLTTEGQCVAASDAAAAPHSGVAAVAALAAAVVAYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6T4</accession>
    <name>A0AC62A6T4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphate-repressible phosphate Permease-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1020030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="XUY37356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="493" mass="52415" checksum="8D050B68C047E48E" modified="2026-01-28" version="1">MADVNPYLWIVIVGSFVSFLTGAGVGMNDLANAFGTTYGARILTLTQIVIVASICEFSGAVTLGGEVTSTISSGVADPKDFAKQPYVFMYGMLCACGAAFCWLAIATWLRLPVSSTHSICGGVIGFALVYGGGGSVNWAKKKSEFPFFSGVAPIVASWFISPVLTGVVSALIYGLVRFLVLRPKNCVRRAMYTLPIVVAIAFFLESFFVLFKGASKRLKWSVDRAAWVAACIGAGAGVLSCAFIPLLKRLVARDEARALAASEERPSTTEDSNQREPLSVEDVRKPREVTGDVVNESEASDSERSEERKVTGASGLQVQQYEWGAERVFRYLQIFTAICASFAHGASDVSNAVGPLAAIYQVYQSGSVEKSSSVPIWVLCLGGAGLVLGLSTFGIRLMRLMGEDLTVITPSRGFAAELSAALVVSFASGYGIPVSSTHCITGGVIAVSIVDVGFMNIRWIMVLKMYGGWVFTLVITAVISAMFFAQGVSAPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RH05</accession>
    <name>A0A088RH05_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_010320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009370">
        <property type="protein sequence ID" value="AIN95133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696675.1">
        <property type="nucleotide sequence ID" value="XM_010698373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RH05"/>
    <dbReference type="GeneID" id="22571761"/>
    <dbReference type="KEGG" id="lpan:LPMP_010320"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_010007500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_010320"/>
    <dbReference type="eggNOG" id="ENOG502SN2P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="260551at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="150" mass="17585" checksum="8D4128D2F2EFA9CE" modified="2014-11-26" version="1">MLFRHIRVVRPLTFQARRMSMRTVVIEHGVPLALYYFITNEILVCLLTYLLHYDYFGQDDLIGFLKFVGASKYIDLNSIEGKRWSFFDERITLSARLVANFTAASLFMSLWTPVQLPICITTYPYLKRISQRLMEKGSFPERIKSCGWVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHC8</accession>
    <name>A0A088RHC8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_010440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009370">
        <property type="protein sequence ID" value="AIN95145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696687.1">
        <property type="nucleotide sequence ID" value="XM_010698385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHC8"/>
    <dbReference type="GeneID" id="22571773"/>
    <dbReference type="KEGG" id="lpan:LPMP_010440"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_010008900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_010440"/>
    <dbReference type="eggNOG" id="KOG0804">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273556at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007:SF7">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="273"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="UBP-type" evidence="5">
        <location>
            <begin position="291"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="133"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="416"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="557"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="423"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN95145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="635" mass="69068" checksum="6B1688F5CA8C5D57" modified="2014-11-26" version="1">MCSTVEAEQMSWIELVRVGYVVSEIHAYCILLKCHRAAQAALIKTALEEGAALGLTAPVEYVSDAQPVIVTHCAFAEPRGEPEAEEVGAGDPRISDHELDGDHHQTHAGARWCTGTHKASLWEAIATVYPIRGNGDSAGGEGHGDDASDGDDDEHTDTCGSLQRHNQYHHPHHLHRSPHTASSGPATPSQARRSPALTPAVRKGAAPPPPRHTSAFTAAVAPSTCNHAPLSPAAAVGRAALSCAAHTPPHLPLAGGGGGGGGGLGPLLSSDFCPICLDPLYLSTCVTTLCQHAFHLSCYAQLPSGSAECPLCRFSVYDLLNDARCKVCGTYEDLWVCLICGHVACGRARRDHQQEHYRSSGHSCSWQSTTNRIRNSSSRMFLHQEVALLLEEDDVEDMSMAENVYSRGAATRLHSADAGASEAGTSSENTSTAKTAITGAVPPSGRNHVLYMSWSDSLMDHDLHEALNESKEEAVAQYYTQFLHQLAEEQQRWYEAKLAERRRRRSERQVVAAGASAGGCRTESTLSHTTLRHIAMDERQQRRRVLSEYVQTTISLLHDAQREYAGMTRKLKAARNEVQQQVLLCSHLNSGLSEQVEQVRQRTQELQRKGEKTSQQKAAEEANLQRLVHETLLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHU4</accession>
    <name>A0A088RHU4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_040130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="AIN95340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703662.1">
        <property type="nucleotide sequence ID" value="XM_010705360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHU4"/>
    <dbReference type="GeneID" id="22571972"/>
    <dbReference type="KEGG" id="lpan:LPMP_040130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040007000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_040130"/>
    <dbReference type="eggNOG" id="ENOG502SM74">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273419at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="282"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="67"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="345" mass="37649" checksum="6EB2964CB0750C7E" modified="2014-11-26" version="1">MLTCSFEQANRAWSDAPLVSAEELSGWASVAEVLLLECARTALVDVTEPSARAQLVIEYADSLAALVQTHVADVAALQRRAASAEEKRGDALARQLHAVAQECEMLGANLVSECTSRAALEEETRRLSNELLSTQGEREALQAERTVVWCAVQEAHAVAGVTCAAKATMEEHVRALCEWVRCAQAELTSAATLIEASAPLPLDVAPYQLACTSYRRILPTTPMNPVTASLLRVKEQIQHIRESSGAQRQLAADMHQHRRDEAAAPLTWSPRTRAAIATMLAPMPRPAHRSPGRPQSYTPPRSTNVSATQREVSTFASPPWRTHMVKLQEELKGLRRELGATNSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RI85</accession>
    <name>A0A088RI85_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">rRNA methyltransferase 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_060490</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703930.1">
        <property type="nucleotide sequence ID" value="XM_010705628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RI85"/>
    <dbReference type="GeneID" id="22572255"/>
    <dbReference type="KEGG" id="lpan:LPMP_060490"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060010600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_060490"/>
    <dbReference type="eggNOG" id="KOG0838">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270651at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047182">
        <property type="entry name" value="MRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46103">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46103:SF1">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="RNA 2-O ribose methyltransferase substrate binding" evidence="9">
        <location>
            <begin position="182"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA/rRNA methyltransferase SpoU type" evidence="8">
        <location>
            <begin position="270"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="126"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="379"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN95608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="585" mass="62375" checksum="60F9A3056A559476" modified="2014-11-26" version="1">MTVRTSAAVLRCTRPLLVYNRSGGYRWSPIPKSPPPHYDRLYGVHSVLNTLRVAAQRRQQQNINPHREAADTLGSTSAAEATPSAALHDVHQSSTVAVPAPPLHPHRAHLACLYVRDFSMEEGGGRAVKLGDDNADDDAGDDGVSSTNPSSLPDKPSHRPERERRACRKKVIPPRYTAVRCITTLAKSLKVPVRFVPRAELVQLCGERRNQNIVLEASSYKPQPIRHLGEIWGAEGGASTTTGVASTTTAVESSAPGVRSLEGAAGLVTVLFLERIIDPTNVGGILRTAFFFGVDHVVLSRQCATCTAAVSRTSTGFLEHLCVYRASTSSAAFLRTSQEVWALRGSSSASVTAVSGLEIIASAVVSYPMAQRRGASEGAPVLPSAASSDSAPSEVSVENGNDNTRACAQQPHPCLPAVRVLLLGNEDAGLPPDLLQWCTHVAHVRSPRHARLRHTRTSTQGGWHREGPEAWDADVEVEVTDTQLSTTSCDSAAVASTASAEGFDKHQHNLRRLARLRGKEVSLNVNTATAALLSALCGVERPLGNGGSQVGLVDVQPLCSPWTPLPPLCPSPLTSHQSNSRVAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RID3</accession>
    <name>A0A088RID3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein phosphatase type 1 regulator-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_051190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="AIN95560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703882.1">
        <property type="nucleotide sequence ID" value="XM_010705580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RID3"/>
    <dbReference type="GeneID" id="22572197"/>
    <dbReference type="KEGG" id="lpan:LPMP_051190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_050016300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_051190"/>
    <dbReference type="eggNOG" id="KOG0531">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266138at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000835">
        <property type="entry name" value="Protein phosphatase type 1 regulator-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050836">
        <property type="entry name" value="SDS22/Internalin_LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652:SF3">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="41"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN95560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="418" mass="47651" checksum="BC925A07E15FE833" modified="2014-11-26" version="1">MFPLVFVSIHQHFRTHPQPPRLMFANLDEEKKARLRERILQAAAAPPPAPVPAKSNSDSDDEQEVPLQHNESMKHASEQLTINAKSTEVEIANIRLFTLDELDLNQLTECKILSLRKNLIHELSAFPQHLAGRLTELDLFDNKIRKVRDFFDSAMVPDPESGSLLKQSVPQAFYSLTKLDLSYNQLRRITGLGSLGSTLKELYLVENKIKVIEGLDSFVHLELLELGGNRIREIGSGLANLRSLQSLWLGKNKIHSIGDSLHSLRELQKLSLQANRLTSITEEAFKEGCNPHLVELYLSENGISTIENLPLHSLHLLDLSFNPIATINETVINPINMPELEEFWLTDGNINDWGEVKKFCGFANTLRTIYVERNPIEQDKRYRDKVYMNLPFVTQIDSWPVLNKNNLEADRLIQRRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIG5</accession>
    <name>A0A088RIG5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_060990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703980.1">
        <property type="nucleotide sequence ID" value="XM_010705678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIG5"/>
    <dbReference type="GeneID" id="22572305"/>
    <dbReference type="KEGG" id="lpan:LPMP_060990"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060016100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_060990"/>
    <dbReference type="eggNOG" id="ENOG502QRBD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272628at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001838973" evidence="2">
        <location>
            <begin position="32"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="756" mass="81734" checksum="DBFD17F010076CCB" modified="2014-11-26" version="1">MFRCASMRRCSAAAMQTLSAWLTTLAEEAVALPSAAAAVLQAEKNNGQELTRRTSAQLWRELEDAATHANALRETDTVLSILQCLLLKQQYPTDVHAWSRLAKKLLPFGGIEQRTVLYYPGRPDASYRREGYPRGSSLAALSSSSDPGPTGADGGFGDEGASRQSSGDTGRGRAQAVPYSLYPSRETLLLSGGVVPLSARVPVGDGRAVSLFVRGFTRFMLTQLDAQLHPQLNSELLQVVKDVSSAVMEALATNAGSLQLELLLPVLLDYMELLHGLDLRTATAISAGPLAAAEEHHDAAGVTRKDEAPNGDGPSSPPSSSKPTRFLQSIANDLAQNAMAGGARGARIVLYYLSDRFAAVVEAHQEDAAATSTEAMYWAQQRYLLALTRACMWAINQHYTPLTAGQSSLSPHAQGLLSADAAADLIATAPMNAHIQALYDHIDVLFQKNTNADNPLGLVDEEVSRLKELHISALLRALRIEESAPDAYLRRALEVVDRVPASMAIEGELIAGKVRLLELDSDTVDEKGRAAIYADLLTSLRSLVEMRPRFSRHNGINLAAAAGGGGGANSLGDGGGVEDDEGDGEQLRLDAATQTILQRAHADVITAFCAAHKEEWSNEAYNILVAHKYHGLKITNDLIRPVLEVFSRRGDCRVFSLVDLCVLYSNAPIDMHTIALLFRTCAVAGDHYRARTFLQLMNEIIPGFLVKCPASVKESLQELKLLDPPPRHLFVSTEDDLVQRALGEEQRTVRRLPTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIR9</accession>
    <name>A0A088RIR9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Kinesin, putative</fullName>
            <ecNumber evidence="10">5.6.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_061010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.3" evidence="10"/>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703982.1">
        <property type="nucleotide sequence ID" value="XM_010705680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIR9"/>
    <dbReference type="GeneID" id="22572307"/>
    <dbReference type="KEGG" id="lpan:LPMP_061010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060016300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_061010"/>
    <dbReference type="eggNOG" id="KOG0244">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="4"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="392"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="580"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="651"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="754"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="839"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="588"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="757"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="797"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="816"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="81"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN95660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="883" mass="95347" checksum="F21994160EC81650" modified="2014-11-26" version="1">MSERVHVVVRIRPFIASDPPDAELNTLVLNPTHVSVGDNRVFKVDRVYMMEDATELIYAESVAPLTTRFLRGFNASVLAYGQTGTGKTFTVQSLLPLLLRDIMTDNGVRSGAAGPPSVETPTSPTGTAPLLYLQYVEVYGETIRDLLEGPAAAASRRNGEEPGNIRLVTTTVPGARAERPRLERVDLQCPPTDEREAAVSATAGCALLGAAIVPIFTVEQAGVLIARGDTRRATGATNVHESSSRSHAILTLFHSRYACRLDVVDLAGSEREKKTGNVGVRFQESIAINTGLLALGNVMRALSRINRAANGKETDQGGGGGHQRSHHVPYRSSRLTRLLQDTLGGNSATVFIACVAPDTYNRDETLRTLQYCSLALRILNEPLQQYERLRRAQSPLGRRGSPSTAMVSPLSLREDSHTGAAATRGCRAKDESMMTPLKVREVQSAYASLQQQYDEQAEVIACMCTSHATTKERLALCERELRKDEGIFTQQIRAMQALVCENQKLRRRLAKVYTTTSATAGATIRQDKAAMVHEPLLRGDDGPLQSTRIATNSRLDNKDLTDAIGDMLPAGARDAVDGVSVSPRLAPSHSQGHYQQHSAPAATTAPTRPPLSAHSPHRPHDVKDDVTDGAQYVPLEELPLVATHKAGVRVDGGRRGAETPTYPLPGSHAGTSHALDGMAPAALAAPDPAESAQSFIRYILNLHGIDPEADEAGNAGGLDRGGGARAVAAGARPFQSSIRKLVATSVGGVALQPAQASKERIEDSRDGHTRRGDAASPLNYALSRPTNRFTMTPPPHTTEELPEEAHSGWESQVRSRRCDTDSVQPDRDSSGVLLLAAELLRYQGANMELRNHIEVLQAELDGKQREAALLRLELQEMKELFTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RK26</accession>
    <name>A0A088RK26_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Membrane transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_110670</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696916.1">
        <property type="nucleotide sequence ID" value="XM_010698614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RK26"/>
    <dbReference type="GeneID" id="22572932"/>
    <dbReference type="KEGG" id="lpan:LPMP_110670"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_110010400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_110670"/>
    <dbReference type="eggNOG" id="ENOG502RSIX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF157">
        <property type="entry name" value="NODULIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="396"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="470"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="498"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="528"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="569"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN96263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="643" mass="70862" checksum="125BB4F4290B5DE8" modified="2014-11-26" version="1">MADHPNTKPHMQLLASGSQGRISDLHRFALLLVGSFGTICGSFGYAFTLVLPRMQERYNLSQRDLASVTTVGLVFGFFMLPFGALYDYFGPLPVAILSMISYPLGAVLTALCFEGLIEGSTVRLCVFNAFQSVGMSLTDIVCCMTVLSYFPSNRGPVIALLKTFPGLGSAIVGSFFAGFFHEKVSDYLFFLAVFAFLTNTTCALVMRLPAYHLTGYQESHLSEEAKERLLATKTRYLKQAPPMWRFILGFIILVLFIVYLPTTSALVAYLSLSRTHKLGFASGTAVLVGMYMLIAVPLPACLRRQLTCRKSRNVSDNDETCESRANDCHLPDREPFCTDADADASAQKAALTLTEETLEGDGQRAAHVPTETDVDYLAPQYQGTFLQNLCTLELWALWWTLLCVFGAEFVIIYNATFILGALQGSAPVTSLTALLTVLNGVGSAVGRLMMSFFEVWSQKRKAEDRVPITIALFFPTSTIITSIIMFLTLPAAALPLPYVIAALGNGFCAASQILVARTIFAKDPAKHYHFCFSATMVASVLLNRFLYGEWYTVQAEKQGSRRCFGKHCVMMPLLVMLGLATSAFITDVIVHLRYRSYCRRVLVERARLHSEVADVEKQRAAVAEEVVCESDVALDTENKPRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RK31</accession>
    <name>A0A088RK31_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_120440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009381">
        <property type="protein sequence ID" value="AIN96372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697025.1">
        <property type="nucleotide sequence ID" value="XM_010698723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RK31"/>
    <dbReference type="GeneID" id="22573050"/>
    <dbReference type="KEGG" id="lpan:LPMP_120440"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_120009300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_120440"/>
    <dbReference type="eggNOG" id="ENOG502S5N9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="251777at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="63"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="257"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="285"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="673" mass="70347" checksum="BCED868DC6DF34E5" modified="2014-11-26" version="1">MPVSFFSSASSDSAAGGGHSTEPPTDMIHLKDALGMLWYAFLLARESHQQPGCQSMWSGVKRTEEDGPLKKDTAAAVEGQHRSSGDVGVDSGSEPKGNTGASISPSTSTTAVSPSAAAQREDCEFDRWGDVDWTLLAAHVYALTRELLSARTLHRIVAEDIYKGMYNGNREAMCAAYALQHAKMLAFHAKEVQEEEERAAVAARLQTPLTINASIPSGSRLAGTAGVLQTAPPAGASSSIAEAPVACLPSMVAIQDSQSSLPTSGNGDGSAAPSLPSTRCNTRTSSLAPPRAAASSLPVSPPLSEAISDARVGVLLVSAGATTATYAPGTSPAPFQGDTDVVGRHGVGGTERGVTTDHMQLGLPPHAQPGSVAGGLQRGTLAVAGQSAASSGESLGPDAVYKGDHAVLPSATHQSLPFEPDPLDAPWYALWCSLPSQQARTQLHLLRYATPIPLEDFSSLLEQFFLVDGADDFLSPVHATTIMEFAGVRSGPYNTIVRSPLSLAEVRRYISESHRHYARAAVAVHTSHGESVARVEARSRPSSGPPSLDPASALGMSSTLETSNAIGSGGCFLAPSVAAATRAEYRGLRRGGAPSPGAFGSDVRSLLDSTASSERRILTLAELERSVWHIAANCVVFNAPESRYPRTARHFAASCIAIMTRYCEKQLAALYAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKE1</accession>
    <name>A0A088RKE1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">60S ribosomal protein L24, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_110910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696938.1">
        <property type="nucleotide sequence ID" value="XM_010698636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKE1"/>
    <dbReference type="GeneID" id="22572956"/>
    <dbReference type="KEGG" id="lpan:LPMP_110910"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_110012600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_110910"/>
    <dbReference type="eggNOG" id="KOG1723">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262490at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000001">
        <property type="entry name" value="probable ribosome biogenesis protein RLP24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023442">
        <property type="entry name" value="Ribosomal_eL24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF8">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN RLP24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01073">
        <property type="entry name" value="RIBOSOMAL_L24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="TRASH" evidence="6">
        <location>
            <begin position="6"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="151"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN96285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="190" mass="22710" checksum="91DF9AC2613E4231" modified="2014-11-26" version="1">MRIEQCSFCSAPVYPGHGQMFVRNDCKIFRFCSSKCRKNFGMKRNPMKLKWTKTFRKANSKELAVDSTMDFEQRRNIPVKYNRELLGDTLKVMKRVEKIKQRRQEDLWARRMEKARHQEKQEAASALKHNIDWIEDIEIKHKARDDLVAIQQEREDKKVKRREANKKRQQKQRQAEKATGTSAFHSAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKM1</accession>
    <name>A0A088RKM1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pteridine transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_061250</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704006.1">
        <property type="nucleotide sequence ID" value="XM_010705704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKM1"/>
    <dbReference type="GeneID" id="22572331"/>
    <dbReference type="KEGG" id="lpan:LPMP_061250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060019100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_061250"/>
    <dbReference type="eggNOG" id="ENOG502QRK9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="754047at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039309">
        <property type="entry name" value="BT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004324">
        <property type="entry name" value="FBT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00788">
        <property type="entry name" value="fbt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585">
        <property type="entry name" value="FOLATE-BIOPTERIN TRANSPORTER 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585:SF51">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03092">
        <property type="entry name" value="BT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="496"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="533"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="576"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="624"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="624"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="644"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN95684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="653" mass="71685" checksum="8D3C52BF031ED11F" modified="2014-11-26" version="1">MASAQPAQETRNGSATDHHEDDATETVRAEYEHPTATKWFRAAPCLRYIPLFGEVTTAFGPKFALSLGLSYTLSKGAASRMINVSRQPMFIVHYGLNVARYQRLASMYSLGWSLKPFIASIADVIALFGYTKRWYMAFSAVLGTAAALAYALLPAKESSANAAAAFVFLTCFAKANIDILSQGHFSRSMRQNPKAGPAVVSWVWAMTFVGTIIASCIMGPLSDAKLTYVGIILSAVLQFVTLFFFIFNLYDEKKNRTNRCKDALMEFQELKRLKQQQAAKAVDGRVVEPIADSDGVKGLAMVETAGAPGEDDDTDFVEPRIYSYFCGAVEVNVDVAVRNWRLIAYALIMTCGILAQVCVTVLGTRRQLLYACIAIALVFVVGAFVSLPLVIAKAAVFIYLNSLLYLQIPGVLSNFYLAKPACLPDGPHFSYTFYQTVGALITDVGGVTGAVLFKYFFSKHRYAFVFIVTSLLQVLGSIFDLIIVKRWNLYIGIPDHALYILGDAIVYEICFVMSLMPAQILMSRLCPRGTETIAFALLAGFNSAGNSMSLAIGSLLIENFWPVSARIPCNFTNVPYLIITGHLCTPLLVVPLAFLLLPKARICDRIDIDGNVVPEDAEVTKGRQCSDLKSHTPLECEEQRPETKQQNAQAPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLB3</accession>
    <name>A0A088RLB3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="2">1.11.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TRYP1</name>
        <name evidence="10" type="ORF">LPMP_151050</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="2"/>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96827.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697480.1">
        <property type="nucleotide sequence ID" value="XM_010699178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLB3"/>
    <dbReference type="GeneID" id="22573525"/>
    <dbReference type="KEGG" id="lpan:LPMP_151050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150015700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_151050"/>
    <dbReference type="eggNOG" id="KOG0852">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="185659at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03015">
        <property type="entry name" value="PRX_Typ2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000003">
        <property type="entry name" value="Peroxiredoxin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF171">
        <property type="entry name" value="PEROXIREDOXIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 9 10" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN96827.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="199" mass="22396" checksum="4A125BF9025A964E" modified="2026-01-28" version="2">MSCGNAKMNEPAPAFEETALMPNGAFKKISLASYKGKWVVLFFYPLDFSFVCPTEIIQFSDSIKRFNELDCEVIACSVDSEYAHLQWTLQERKKGGLGPMEIPMLADKTKCICRAYGVLDEKKGVAYRGLFIIDPKGILRQIIVNDMPVGRNVEEVLRLLEALQFVEKHGEVCPANWKKGDATMKPERQASIEGYFSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLZ1</accession>
    <name>A0A088RLZ1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein kinase, putative</fullName>
            <ecNumber evidence="7">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_160840</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="7"/>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN96958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697611.1">
        <property type="nucleotide sequence ID" value="XM_010699309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLZ1"/>
    <dbReference type="GeneID" id="22573662"/>
    <dbReference type="KEGG" id="lpan:LPMP_160840"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160012600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_160840"/>
    <dbReference type="eggNOG" id="KOG0589">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1924919at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:002921">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF103">
        <property type="entry name" value="KINASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="347"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN96958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="686" mass="75061" checksum="F7D4A05569F2561D" modified="2014-11-26" version="1">MASNSDNVNMPLQRSGEHNEMTPPRANKGNVAHAQPPSGMLDSANTGSSAPPISHQFSLEGLPVLAPLSLGQPAPQHAAMQQRMEGTLLDSEASPKYGSSLRVHTPTLTPTLSSVTQGFASGEFPSPYLPHRHSDTYEKLLPPNALGARQLIDYIFTPPSPGRPYSSLCLPSVVDKPSPHEIGWPMPLPAEPVNSRSGRRLVFFGKGQQPRFVLAERRNRFIAVMPRPILSDTSAAVVGAAPELGYTGAGTGYTSYGTVLGYSDDNTKIVWNNRSERFASYVSLSSIQTIHRASAMQCKHCGFVLLKQELREHMSTHKKGSGVEYGVFTDDESLGMLCGDSGLMQNLTSPRRLGKGAQGVVYLMKVAQPTTAEVAQAGPSSAAYRFISEQLSRETRLEKVVLKSMQFSTEAKALDEYQKSVRFMTVMKYPHLVEYLAVQLRPDHRTVCICMPYYEEGDVGAMIRNFRGDHFDESFVCSVGLQLSLALGFLHERNPPIVHGDLKVENVMFYNNKQQIVLMDLDSSREVLGGYQEAVQSSLGTTAYMAPETLKVERLMPSSDMWSLGVLLYVLTVLPDFPMILNPNTQNLDLLNADCWATKEDLCVMESYFGALRGGCSRASSVAGGGGNSGITLGECVRVNVTRKGYTPELAQLIVDLLSYNPLKRPTADTVGSRLTAIMTDYLLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMA2</accession>
    <name>A0A088RMA2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Membrane-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_170150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697706.1">
        <property type="nucleotide sequence ID" value="XM_010699404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMA2"/>
    <dbReference type="GeneID" id="22573758"/>
    <dbReference type="KEGG" id="lpan:LPMP_170150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170006900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_170150"/>
    <dbReference type="eggNOG" id="ENOG502SK7A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264762at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839003" description="Membrane-associated protein" evidence="2">
        <location>
            <begin position="42"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="668"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="734"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="768"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="803"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="866" mass="94387" checksum="BE736B06C7DCBA83" modified="2014-11-26" version="1">MVSSNLLPRMCRPSPPQSVLCCTFVVVIAAVLLLKGTPVCGHDGDSVDEPPSASTAYTERTFTLPTAASLLDVLTSGSYIATGGVEEGSGAPSGLPLPTHPVLILFTESSAANSPIVDSLRAKVRHIATDMPSSALRVHEYRIPMGTTERRLIELLLIGASSIPTLALFHGRVAKVQVAPGATIAASPFQIPVYYSSKSLTSASYLELRSWVLSELPARYIDPVTFHLMPSLQFVFSPSEVRDTLKLVRDSAEASMSRSVLPAFVSMSYMRLTRHGSEEVLAALSSIATQAGNALLTLVTESSVVAAAWGLRTEHTFSMAPWSSTVAAYLNDSTSAGFVETVSDLSPPQSIGTVTELAEATAASAAWRAACAASVGAEVAQLQKWRQAMDAFNTTNPLRKLDSAAHLLHELTALQRAMKIIFVLRESDALWFHHHIDVAAALARRLQYTTVFYNTTLAKGSKERSRVERAWTPIMRTEVFWLDAEQLPAVAEGLHASQVPSVLILVPLQSRFNDGAATAADDDQAAANAAEEEGLRSRDPVLGIHTINQYDILKATHMGDAQVTQDTVSGKDALPFFPSDSDTLLRFFASGSFIAAMQHTLSSTQLSTFWASIAESSDAAQASTVSGGIPNRRYLRLDRRYYPLGAAEEPLEGPEYVRAILNGSSPLPVLGNDDSDTAAERHQGGGWSGTPLRGTTSASPDEADEKSRRRLARESAAKLKRKAAWEADLAKRQRAKAERMRRKAAEEATERERLREAFRQEVKAALKAEMEGSGAGDTSKSKQEGLLVRRPSLVGASEDFAGRRHSSRRPRRTSGDEEDAEDSAQRLRRRRRHEEYREWLDDRQRMVNRCVTVTEKSGFSVITRWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMH3</accession>
    <name>A0A088RMH3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatase 2A Regulatory Subunit A helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_180460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697880.1">
        <property type="nucleotide sequence ID" value="XM_010699578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMH3"/>
    <dbReference type="GeneID" id="22573936"/>
    <dbReference type="KEGG" id="lpan:LPMP_180460"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000038900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_180460"/>
    <dbReference type="eggNOG" id="KOG0211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="340346at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000514">
        <property type="entry name" value="HEAT repeats/HEAT repeat, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055231">
        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051023">
        <property type="entry name" value="PP2A_Regulatory_Subunit_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22956">
        <property type="entry name" value="VPS15-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="69"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="115"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="154"/>
            <end position="192"/>
        </location>
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            <begin position="199"/>
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            <begin position="272"/>
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        </location>
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        <location>
            <begin position="626"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22956"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AIN97227.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="709" mass="77431" checksum="58F42456B58A6615" modified="2014-11-26" version="1">MPTELLDDSTQDAEEEFIFNEYAIDDSLDPLNRLLMYYQSDFSLQRLVLVRELSSTAHFAGYAESARSIVPLLTTFTQDAEPVVRQALVEQLFPLAEFFVQQGSEAGYQCLLNVFLPTAFELLVDKNVEVGVVALEAIQKLAQLVHKEDVQSHLLNVVMTLAHDERAEDYRVVAAQLFNDLAPQFGSEFSTTVVLGELELLSNDSSFTVRRTVGSNLGGVCAVLTTEEAQRTVLSLYITLCGDEIWGVRQACAESIEKVSSGLPELMRVQFIVPAFQKLLEDDSRWVRTRAYESLGRLLHTLRSEDISPELLRLFTDMAFQSDNVESPLSEYCAYCFPAVVQAIGPSRWNEMADAYATMLKDVQWKVRKSLAYSLHEMAALLGTKVTEEAIVPAFELLLRDLDDIKRGAVLNAERFLALVTPATRDRLVPLLCHVPLESENWRLRNEVAKRIGAVAVLLSPDSPSFPSVLALVSRLLDDSVMEVRTSTYEPVAIILKHLRAANDEKYQNYLASIVKLATAYSFRGRQMFAYVTEQVVKVGADDVLESALLDGIVKLAMDPVVNTRLVVDSVAGRTILRNTKWAENNKVQEAISVLKQQAASQEVVDVAAEAAEAAVANTQILNGSENGVGEAGGMGMQREEQQADSGGPSPALQCGPDTVADGAEGIVSEDNDSPGCGLWSQGTPAVSAVAPDSTSSVPLGGATAVGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMK8</accession>
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            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
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        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_010699426.1"/>
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    <dbReference type="GeneID" id="22573780"/>
    <dbReference type="KEGG" id="lpan:LPMP_170370"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170009100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_170370"/>
    <dbReference type="eggNOG" id="ENOG502RXJA">
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    </dbReference>
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        <property type="component" value="Chromosome 17"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="695"/>
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        </location>
    </feature>
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    </feature>
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    <sequence length="1151" mass="124728" checksum="2E845F136B605417" modified="2014-11-26" version="1">MYIFELSTASPCRSAPYYSLVIRKPYILGQDAAADINLAYEGISAEHVSMTVLNEKEAALEVESAIRATAGTEDGDAAVNGALEEQDSGAAAECIEAEPAAAECIEAEPAAAECIEAESAAAEANGCKLVVRVTALLTKGDAEVRLGETSLRAGDSAIVRDGDVLYLGDGISGTFRYRPLVVGIEGGAYPEDYLNDLHRMFDQLGATLVDMPIPLHEMSATPIGQLYCTTELNDSTSCLAALSYGYSIVQPTYVFEWFAAVARNAAAPLSTLPAPSRFEVTVRCPTHPISTTYLRPESDTCPFSLFPIPLTAMTNRSRAALFSNRVLFFFTDTAATRYWRAVKDCGGAVYGPGDVEAAKEAVQALVVSQREAGMPSDCLPSNFYIIIDSASAAELLSSGIEVASPELHAFMEEVRAISGATHLPVMGEHSLFAALLGNKFCEEPVPLAAAPPTASGVGYNSVYCDLSDAFAVPPPTHQSEGDEEGVRAPRLGYFSSGGAPFRVRSTSRVSESRASLPHCLTAVPQPWNQMRSFSHQRARSLSTRAPGQSNDGSFYAGSMTPSRLGRRRLTSFVAHVGLRSFVEDFDMLRVRIYAFLVREESKLDRAITIYHRNYFIDNDTMKYALDIKAQAADFMERVDDLLADSACRGAYKEALRCFWKDCSDMDIRAQHLLHYWDRSMPAAFLTRRIRSRRGSSIDSRRAASSRSMASRGAAPAANSPAPAAREEEPVTLDANEGAHEDAHEDAHEDASEDTNEDASQGAHEDASEGAHEGAHEDSNCDAGDNQVAETFVYTQDPDSSEEAHGHDELYTTPEALEQLDAESHIQEHHITTEDDAAGMDRSDTVAASSAPAMRAASSPYSPHRRTFTPSLRHSRGGIRASVRRPIPIQERPPWVSNWNEPQSGRKKKKRQKKSKQQQQQPEQQPEQQQQQPELDKPASQTPAPTPAPRAVPRIRLSVVLPEYATDSPKVVRARSAGGGGSTHARRLPPLQLEGVRDTDEEGARDTDEEGARDTDEEGVSETSLELDLSNAVSEALTITDQAPVEALEAEEAEKEENQARCAPTPVPEPTPTKKTRASKSRRAAAPIRNQRSNSAPVSKRTSSGGASRRPSGKRAVATNGNGFYKRDAPAGVVSNGKGSRQPRRPSPKRKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMN9</accession>
    <name>A0A088RMN9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
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    <organism evidence="4 5">
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        <lineage>
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            <taxon>Trypanosomatidae</taxon>
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    </organism>
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        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
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            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_010698850.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22573180"/>
    <dbReference type="KEGG" id="lpan:LPMP_130700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130011300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_130700"/>
    <dbReference type="eggNOG" id="ENOG502RXE1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266920at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47246">
        <property type="entry name" value="MUCIN-19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47246:SF1">
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        <source>
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    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
    <sequence length="2623" mass="274605" checksum="DCCAE9DEAE770DFB" modified="2014-11-26" version="1">MRRNGHAVPPVAPSFEELKLKRPAASNQGDNTVTVCNSEASNSSPLTLETDGGRSDNLLHGSDQTSRGGVAAHSSSHHRYELKQQLPLQHGRSRRNSSGLGKSREPSTSSFETAIPLGDAVQQAPLLHTTASDTDNARYPQAGLPPSPPHTTTGVPAPALSSSASAIDAGARAANAAVPFLFSLKLPSTTVTHLGVGRASGAGVAQSCDSLNGSMSSALGGSLLQSRNRITGTGEAAADSGTSSPWRVNETTGAGVDSDHHSHHCQLQPGSGEVNTTATTLFPRDVGPLPASEAYTRNRLPSGTHIRRRPRSVVRQYTGVAGMASIRNGASSTKMAGDAESASPAYGTLDASVSSVITLASPHMRQRGTSATFLNSSVSGSGTVTRAGTGRTRDVLPPGTRSSTVIGAAAGAVRRHRADPSPAPSRPPRSRRARPGAAPGTLSGGPSSAAVSGPTFSPSSPAQLGSRVSHQPSVSLQVPKRLLLEHSSTGASSPLNGSLEHGSFLLAGDKDSLAASTSAVANHEHPISSCYTNKRSGRSRVHSAGTTVVTPSTKPPSGRRQGSLARVLAPMHHSSSASRLEEHCPSSPLQDYAKLAATYMKLCADVGDEPNMDWVAALPLMKGEESQYDILSASMTLSTADAKELSTNHSQRAPGLLNGSPAVSGHFLRSGPQQLQQQHTPRGGVRPRIAAGATWSSLSATMTPVDISAPTSTSFVSQRASTPAGKRAKSPGVRHGASSASSPSTLPKRSGSVGRITSVSRPSIFGSSTQQLQHTITGGKRTPRTHRDGSATSAVSPGAVETAMADVYAHKIARYCAEYLQPFVDNMKSVREQRAAVTVALQSFVQVARTSLSASTAAVNTAVTAEKSDGEETGLRSAVSVQGHHYDGHSNRGLGSDRGGPMSGTIPSTTTSSTSTTPRKFSISRNSTTSSLANTTTTTTAGHMCRRASAAAAAASKAASLSDALQTLQAAVVTLLSTLSDGTALARAPRNELLSPVKNVDKGSTPLDSQPTLMEAGIITTVTSCSLFSPDESASGRFDKAPAAPQLVSSALTPTIDLATSPTPSLAHTSSGDGGSSGLPGAPRLTLANAMTPSGVGVDQLAPPLPGVTGVGSGHTSQSQTSAVGSSATTAAASSADSTTSNGTAPSRFVQFVCAQKREVVAQLDELCGAVRDALGLPVTAPEAATTQRSMENSVGGAPSVPVVWLEVPDMLSTPFFVPLKHLNNLLTSMARQSGDDATAEEDAAATTSSDAIVTSPTIATFLKSSNISSFPKFSSNATGNKAKSSKVSSGGGSITGHSSASSTPRARANMTTMPYAPLFTFTTTADEDVVADGAAGEDPQVRSVSARSTEGASGNAYTAVECYLLRCMQPSAGAGTAVYSTLLGTGSGRTSSRQNSALNWTTTDLSASVESTHGGGAATAKVSTMCKTGSKRSASPGASYSGRAGGAGGGWGSVYQSRPSLSASQKAPATTKASASPRKSRKKASVVSKLSQTQKGLTQQEKNEQQQQQQQRQLAKAWTLWLSLRPLAASQNGVASAGAQEPPLPSPHPSPVVGGSLSDCTPTEENEAATPPAMSAPTAAATPAAATRKEASPNSKGGPVFECQLPLEADDEEAAPVTHELQSPPPQQQQPGVLNGLRSHNDGSHLCSAEEKDNGDVLHSELSDMRVHAAGSMPRLLSLQSVPQRLNMDDTALTHSDGAAHSTPSAQSSAATLVYSFSMAMSQPTVPLPNSASCVEGSSSVSTNAMVPARAVAADTHKAAARQIAVWWASLHCRRRAVAQHRGAHLAENVTQRERVLAARRNAFVRLWVFRWRLRRRIEEHQQQQQVVASAAATVAKRAEHDDSEKVRRTAAEMDKVEASPTTTTTTTAPTSRERFQRAKEQRKVALASAAAATSGTARVSSSPSTVNSGTMGTASCLPIRIPPLPLAASGISTFAIRNYQGESSSFAVSAMHRLLNAPLPLLYATCTVALRYPTNAPMAYLDNSSSGSAANRHLNGGEERQKSEAPPATNEHDADALTAQQRRWIEKGVLYTRLLNLRHYVCGKYEAIIAVSDRRTFVDEAPSSSSGCYALSSFDDTLNSATRAYRGTSRPGATSALLVPPTMRYESVVDPKELKHAKPVVKAFHRPFEKWGMACNLTSRVFCAAAIYAWQLIFSHTPFDDAKQRELPTREEQQARLERVEDRNSIILDCYGVRSEREWLREATKDLSFVSQIYLPNYDQDDPEQERESRDSYDFVKNFLFQCFPCIHKLADIPDYLVGSGLFFLLKEVFHYTKDSPSMQQVYETLPRLVVVEGEDHIAAVTPATSALACNDAAAARAERNATTEAALGLPAQATTQCSSLPSCKVTDSGDGVKGLSGWQRAALQRYEQLRQLHHLTYGIVEQEKAVAALGSDAGASGLPDKMKQSKQHHQQKRSRSLATSTASIGGAAKDSVKAASGYSGEDSSNLTSSASPKTAVDDIIFPLRRCITNNPAGPLTLMRSTPVSAAFSSSAFASPCAVERRASSAAIAAPARDVCVQLVRVPRRLLRPSAVDAQFVRDFEEEVSKSVHAIIRAWRGSGGGVSLNVFDLRAALTADAALHDALDIVYPKHFLVKLSETLSLELFGLQVSLSSCEDLDSMGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMV2</accession>
    <name>A0A088RMV2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PA26 p53-induced protein (Sestrin)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_180470</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sestrin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697881.1">
        <property type="nucleotide sequence ID" value="XM_010699579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMV2"/>
    <dbReference type="GeneID" id="22573937"/>
    <dbReference type="KEGG" id="lpan:LPMP_180470"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000039200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_180470"/>
    <dbReference type="eggNOG" id="KOG3746">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="337464at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070728">
        <property type="term" value="F:L-leucine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016684">
        <property type="term" value="F:oxidoreductase activity, acting on peroxide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071233">
        <property type="term" value="P:cellular response to L-leucine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990253">
        <property type="term" value="P:cellular response to leucine starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016239">
        <property type="term" value="P:positive regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901031">
        <property type="term" value="P:regulation of response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006730">
        <property type="entry name" value="Sestrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12474">
        <property type="entry name" value="P53 REGULATED PA26 NUCLEAR PROTEIN SESTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12474:SF0">
        <property type="entry name" value="SESTRIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04636">
        <property type="entry name" value="PA26"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="121"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="277"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="994"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1205"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="497"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="994"/>
            <end position="1011"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN97228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1280" mass="135037" checksum="75D3B160AA7FA5A6" modified="2014-11-26" version="1">MPNIAASWVPPHPGGGQWSDHSNNGRDAAAAALEVFQDFTWYSATLLSHLFALEHAQLERAAAVEESHRRAAAAHSPQLLMSAAVEAVKATAGVAPASAAAATSRKISDRCSLGQKLEFESGEAGGGADGSGSSGAAALVTPSLSPSAPDESQKLSQIATQHRPHILLGFSMLGDATAMGVVDPVLADSATRWVLPQATKVAGLPAALPAAAPTAAAKTSASDTAITALLTVFDAYYFPSDLFYAADTVSSAMAGEDGEREDPALLGGDSNAMHVARDGAGNMPQGGTTSAEATGPGTGSGTNAPSVTAEALREAFHALLVLGQRCAVFALKHRGIIGCSGDAAASLTGRGCADFESEGGTDRRYSPRIDDENLPTTAAAAQMDDVTGTGFSSEDDARANEAVQQAASASLQFLLQLACSCPCASLAYAAQLCVAHALAVQPPPCNSTGWIARQQLMRYLPTLQPQSRGTSAADASVNSTSVGGLQKHCSLGGGGSSTASASSSSGNKSKCVPTTQHVRPEDAMLWFDTAGEVHLMTAQHWWDAQQPQHSATCLAYCGPLPATTALPTVQRVLMEEEAYMGPNGSAAAALKSVLEAVSTEVCLNARAIPGSPSSRVPTSLRRRRGVHHFVGTSAGGSCLSTGDGEDGVAGGREQNRSSRLAGACAAVAVTSGSGASVGRAQGAAVVETSSRLSKVAKRRRALLFALAQSHLLPPVQQLATSKTLLYDVFTDGGECPSYYKLLSLYPEVLRAHHAALNYVLFGEGPLLVDMRLMVAVMAASRHRCEYLVSRFSALLLRYAEETKLDEYVDDDGCGPGGGCGMMRGNHHGGLYSSRDTRGHAAYGDKDAADTYEYDDGAHFASTSTGLRQQKQRHHDTSATGCFRGHSRQRWITHGPPERLRAVQHFIALAAHTPWTLGEEEIRNILACGWTIPEVFQLVAIVTQVVPLCGFVMGLFVPTEPWTMTLLPLEVVEQLSHRAVTEDVLAGSSGSMGSIGIGGGRNGGGGERGSQTGGRAPSAQEDVYRRFAGDDNVVSEQRIKGGTTAANPPTLWRSRFTWNDVGATSMEHYYPGAATLLSEEMECYFDVVRQLTKADCVGLMSPDYDPSYAFRSLQLYVQNLVGFMVEDYSYNDINKVLRRPAKWFAQVLTMRPETLSRSEVVRWYVPTIPPIGKASNTSAESSLVTHQLKREIELLSVVDSARGGHRGGIESASAHQDNGDKIPPTPAEAARDAVESEALQTALTLQDERVLLLIALATMEARKEGLLHILLRPVCAVLNNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RN53</accession>
    <name>A0A088RN53_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Elongation factor Tu, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_180740</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697908.1">
        <property type="nucleotide sequence ID" value="XM_010699606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RN53"/>
    <dbReference type="GeneID" id="22573964"/>
    <dbReference type="KEGG" id="lpan:LPMP_180740"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180010300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_180740"/>
    <dbReference type="eggNOG" id="KOG0460">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2067at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000576">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000161">
        <property type="entry name" value="Elongation factor Tu, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000766">
        <property type="entry name" value="PRK00049.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009373">
        <property type="entry name" value="PRK12736.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF22">
        <property type="entry name" value="ELONGATION FACTOR TU, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
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</entry>
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    <accession>A0A088RNJ0</accession>
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        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
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                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
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            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
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        <text evidence="7">Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization.</text>
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        <text evidence="7">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
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        <subcellularLocation>
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        <text evidence="2 7">Belongs to the DPM2 family.</text>
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    </evidence>
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    </evidence>
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        <source>
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    <sequence length="114" mass="12190" checksum="796A326E04638B9B" modified="2014-11-26" version="1">MMTDRALGTLLLACNSSFFVYYVLWIGVMPFVDESHFTQALFPPREYGLLLAALMMTAAVGIAMLVGSLHTIWRTGYVPLPTKAAAMTRVNLLAASAVAATTDGVVPEVPIAAK</sequence>
</entry>
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    </organism>
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        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
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                <person name="Restrepo C.M."/>
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            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
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        </source>
    </reference>
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    </dbReference>
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        <property type="component" value="Chromosome 15"/>
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        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN 2"/>
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    </dbReference>
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        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN 2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        </source>
    </evidence>
    <sequence length="2560" mass="268168" checksum="587400C8598DB157" modified="2014-11-26" version="1">MHASPRQGAEPGSSQPLRGRLSLSSSEEPAAVHLYDLDTVFLSKTVVSLTDVFAHSVDGPFDLSPLYAPQRQGVENQQQQQQQPQQAAATTASSPYADDAHCAPSTSGAAPAHRGITNLPFSGGSAPYTSSSPKPAARLVSTRATALQPKPVERGADGRWRTVSANRGASSTGFSTTTACSKPPSPETHARMLLVPLDTYHFLLTYHDVDLPGQLSSCCNKQAATATVERLSAASPGRRPPRSGICVVRRLEGEQRDSTAAASSAMAAPAGAASATPPTLSRIAHGLPLDAFDGWVRDYTAYGLSCNEAVLRAAWENKTRERAEAPSAMLAGAVVEVGELVASGHEATDSGDNSLCGSGDVAVVDTAALGPQVSDASAKMMPTDGAAAAEGKEAATLADANAEQAATVSPSLDRLHCSSTTSSSPSAASTPSPPTERGEEGCNVGGVETATRVTGGESGDALDAISASLMGTAAQQQQQKRVLWEEEQQRTERAAAQLRHRFLVSDSAQHAIWALEVRLPAMVVRALAPAEFYTMGVGGSGEEVPAAAKHSENDGNDDTLATHGATDTREEPAAAPMPGIALPRKKTASTITHGRAAASGHRVSVKASSAADASRLRSPSPANPSMATNANKADDRSDAKPDDSDARRFSTSVATHPASESCSTGRYARSASSVSPSVAMALAVPTPLIGGARGFVDGHFSVARFNSPASLCWRIDEDNEDDDEKGVVGDGGDSDDDLAQGVVAAFQENHGRGRVSAKHHCVDPVSRLRGRHHCSILFISDMGNCAIRYANFYNRLVRTITGVDGVPGYRDGSCVSSLLRGATALAWCSAGLLFTDGANNVVRLITDIRKRRAQGRAHDNSEDVAGADAAVSLACSSTRATGSEMQRPNELEVDHRIPAATERPRCVGDKSAGGSLDTPIVTATESQDGELQALPPAPSSSPLSATRRGILLSSAWKRDGTASAMPRVWTLAGCTSDADVNQPTQADSSLASYVDSVVPSRAHFGYISDMALWTDETGDTQVLLVDQTHHALRILDAHGGVSTYVGPLDYEVTSIVSPSTTSTPAADSLPPGLVFPCCLTVGALIKERSPALLSATTTGTATMITPQPYLCSSSPLLFTASAVTGAVSVLLPISQRSDRTPWSVRESQRRRRVAETREGKVTCNGDNDDASVFAAIRGALELGVATEGRRSIGEAAMPSLKHVVVGWAADEVDGGDEAERAHAVRQLAQAANAQQTLQYLRLRFPWLLPPSVPLLSTRIVAGCACHVSGKRRGATAAAAAPTAASNAVGLHYNTNNSSRQGTGAPSGARPNCTDEKGSTATAISTSTVRPVQQQQRLLFQSPPRHPPIIPPRNTAATTGVATAPAAEMAAVLLEPTLRSAAPPGMVEMLLDTHLGNVSGDSAAAGDRQALCVGSRSPSCGASPLSPNGDLIIEEGKSGSRQCGSSSCLKSEDGKEEEKKADGGDVGGGRAVAKWLAPPMKSVSRSPSGSRSQGQQQQQPTYAGLLQMWTPEKRQQRLRSTQEISIPTKSASTSPCGTPRAVYKQQQQQAVEEKGSPLQWPQSAESGSPQRSQCSPQQLLLRALSSSRSPRGCTTSPNNLSGCGSPPLTPRAMVAHQLMQRRRTSRSNTAPHLASVEGGGRSSTGSKRTAVADGHDGTSPPSETQQQEGSQGPAAPAEPLVVSAVPDRRTPQPCRADWQLHDAYDAAVRRLFRVYNYLATKTVTTRTTATASTLPLGAGAAGAGGSADTRIAAVESRRGSTPSPWVTHQPRQVVQYTMSFAAFFRFVVLTGYADCLAEVAAAAVTAAATDTQGKDDDDTRAAARDYSTPSPVSPLCRLSQVQQRRGGGGGSGAGTRRWSSASASSPRAPTGATSTVTSSSLSHSRHPTSSDVLLVPLATTDTRAIAAVLYACGVRQKGYHTVTQMDFQSFRRAALLLYTWARTATSAEMAKRSETADNDGAQSGRFSAHRKADRQNCADPADFAYVDAVPSLDALTSEEVVVAYAAVYERAARCIPALAMSLGPFGASKGEEDHNEANARDNARQRSDVLQHSHPVSSMRPSSKAPLPLVEVDTDSPGATPSYLRCFEEAIGYSQRGVCVSGKAAGVDEPVTPPVSPIATTGAADDVSCFVLDCADSVRSPKAVAKETKLAGQSGDDAAVLFPPCGLTPYEILALDELLRLLQRNESTLRQLFTAYSVPIAVHRSPQYEAPLSAAAAAASSSCSLLMSSPEVSLVLRGGERAVARHPRHAPATPLASTCINTSPAPAGPPAVPHCSRQAVGNARATPSTRPAAATAVAPLDVVHGSAALSGVSTSQQDIWWKVQQLYTMSSLENKETYELTSHVLPVVPFKLFVELWRTLDVFPSLMRSAAMQQAFCDALTMPMLRGLTPPPGSTSDAAFQRQGQPPLPSLTRSADLSNRRTVELLCAHGGLPYACFVESFVRVALTVFSHKVDRIAYPTAAAKTAGLMQWCNKQVTLGLVAKRVQQQLSVTVVRRHEPSRRSSTTPTDAALRPSAAAAAATTATISAARATRAAAIFPDQLRLFCLPTAPKSRVAPPGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNN1</accession>
    <name>A0A088RNN1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA mismatch repair protein MSH3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 9">DNA mismatch repair protein MSH3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_151370</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697512.1">
        <property type="nucleotide sequence ID" value="XM_010699210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNN1"/>
    <dbReference type="GeneID" id="22573557"/>
    <dbReference type="KEGG" id="lpan:LPMP_151370"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150019200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_151370"/>
    <dbReference type="eggNOG" id="KOG0218">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="121051at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000004">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003230">
        <property type="entry name" value="Mismatch repair protein MSH3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF154">
        <property type="entry name" value="REPAIR PROTEIN MSH3, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="11">
        <location>
            <begin position="852"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="147"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN96859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1006" mass="107410" checksum="F71705999005D55D" modified="2014-11-26" version="1">MSKRGRQEAQVDVAHAIEVLCCRSAVKGETEGVSLTPLEQQVVALKESISPHVILMVACGYRVKFYGSDSRAVSRRVGIMCIPGHPFEYSSFPYTRLDLYVHRLVAMGYHIGVADQESAAMRAADGLKSGLFTRSVSQLYSRGTLLPTERVSNSGGSGSSPGDASKTAVEESYAGAEAEEGDGNAISWPEPHVSPSSDSGTSELFLCFVDAGRCCSRNGTNGAGDASTRARPLLSVVLVSFVTQRCLRFDVRGAIELEDVTQRYDIAEVIVLTAQPPSKECGSRDVSSQRTTVSFLKALPEVYATVLHHGLPLNFGPTANGEEDGKDVSVSGYVYAAGQSIDAAIEAYLKPYRLDQVYGLLCARGGLAAESLCKNEEAAAASSPAHNYASTGSSLHCLHLPGPTLRALDVFHSSVGLRGSLIGLLNHSITPCGSRCLRRWLAAPLCERSSIVARQEVLLYLMGHKDNGQVEDLLRECARLGDVEAVVSKLYAERCQVVEFVRLLHMLRSASVLAAQLCNGESDVDLSSSRPPPLLAQLLAVVHGAAVSRLLEGHAALLRTAATTPLEFFTEGGCAVPDALLPHLKARQAAETALQAELEAARKALNLPGLEYRTICGTPFVLDVPAGKCAHVPPDWLVHTRTKTNVRYHTPIITEQHTALTAAAERLSLAATAAWKQHQRDTVADAEVMRVLAGVVEAVASLDALRSLAVVSQHPGYVMPALVALPACAPLSSTSVSSPVALTISQGRHPILDRLLPHGYVSCDVQLRVGGAWLLTGPNMGGKSALMRMVGTFVVLAQMGCGVPADAAELPVFEGVYCRMGASDSIIEGASTFLSEMDETSRILRAPQLPHSLVLMDELGRGTSSFDGAAVAAATLEYLLDRRATTLFVTHYCYLCDPYVAQGTTGGGEGEKKGASVDEARDVTCYYMGFKESDTSSPTEYGTKPSLIFTYTPCRGVTPSSFGVAIGREAGLPTEVTDAASRLSAEAEQQHRMRQDLDEVRRFLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RP13</accession>
    <name>A0A088RP13_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_200720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698272.1">
        <property type="nucleotide sequence ID" value="XM_010699970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RP13"/>
    <dbReference type="GeneID" id="22574279"/>
    <dbReference type="KEGG" id="lpan:LPMP_200720"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_200720"/>
    <dbReference type="eggNOG" id="KOG3241">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="250548at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019351">
        <property type="entry name" value="DUF2039"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22876:SF5">
        <property type="entry name" value="CHROMOSOME 9 OPEN READING FRAME 85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22876">
        <property type="entry name" value="ZGC:101016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10217">
        <property type="entry name" value="DUF2039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="209" mass="24214" checksum="B7457F695F09E2D7" modified="2014-11-26" version="1">MKRTIKSGAPGARQAYMNKSKYNPNRYKLEKDHIWRQVEFTMTSLCCRRCCEIIQWKVDYGKYTLQEHSRRCNLCRENKVAHAYHRICQQCAEREAVCAKCQKHPAASTVSANADVPHNDSDHESLEGHIENLEKPRETTKYAFVDIASHGEELQRLTGLNTRVLQQKLRKRREAENRDSLGTLRERERRTALRKGIIQAEASDSGESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPC7</accession>
    <name>A0A088RPC7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">hydroxyacylglutathione hydrolase</fullName>
            <ecNumber evidence="5">3.1.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glyoxalase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_203130</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21864"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58896"/>
            <dbReference type="ChEBI" id="CHEBI:71261"/>
            <dbReference type="EC" id="3.1.2.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.6" evidence="5"/>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698515.1">
        <property type="nucleotide sequence ID" value="XM_010700213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPC7"/>
    <dbReference type="GeneID" id="22574524"/>
    <dbReference type="KEGG" id="lpan:LPMP_203130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200037200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_203130"/>
    <dbReference type="eggNOG" id="KOG0813">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="515692at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004416">
        <property type="term" value="F:hydroxyacylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07723">
        <property type="entry name" value="hydroxyacylglutathione_hydrolase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035680">
        <property type="entry name" value="Clx_II_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935">
        <property type="entry name" value="BETA LACTAMASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935:SF94">
        <property type="entry name" value="TENZING NORGAY, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="11">
        <location>
            <begin position="170"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN97808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="518" mass="56542" checksum="50F3FB44603526A8" modified="2014-11-26" version="1">MSKLLSWMGPVAVGASVAYVYAANHPSANQLESGVAYQFPLTTLKYCGILFLIYVSGVMPRNPLFPSFVFRHNIFPLLYKLYCSYAIGYCVLRPIMHHPVAYPHSNHHNGIRCIDAGSPLRLKRAPPGTTDAFSFLTRFYARAGGVVDVDLWNGSAVRGVAVVPVPIFGDNYAYLIVSMQTHKVAAVDPADPEMVLRIMESLRTTLQIPLQLTEVLTTHKHWDHAGGNEMLAKFSKKELSVPPRGEAGVNYASDIPLLDPNLRFIGSEEDAPLCCDVLVNDASPVFEIMGGAAKVQAMAAPGHTKGSLVFVVGSAEEGVFTATPARVAVFTGDSLFCGGCGAPFETASVAQIMKARATFLKDPRMRTQPGTGQEVTDEDILLYVGHEYTERLLTEVMTLMTRVITRSRAPCDPRCKDYVRAVADSLREVKMLRTESDGLTDAAHIGCETDTQKPRFRLPSCTVPSSLAVEKTVNPLLTVDDEVLVALAKAEKDGPIDSNEVERAIYCSDRRCLPTLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPF8</accession>
    <name>A0A088RPF8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_201710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698372.1">
        <property type="nucleotide sequence ID" value="XM_010700070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPF8"/>
    <dbReference type="GeneID" id="22574380"/>
    <dbReference type="KEGG" id="lpan:LPMP_201710"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200022400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201710"/>
    <dbReference type="eggNOG" id="ENOG502SJNM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="260004at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="434" mass="46431" checksum="0274AAEED6A89012" modified="2014-11-26" version="1">MLPSGFPTVGGRSLVSNSVAMHANPIHFTTPPRRHIASLSANVELTGLTAGVSLAHKELSACNVTGRVFNCTSMDGTPRCKSSVSITAVVALSTDVSPRQHRCGPSFTSGIMTESDSPCRSPRVCLTQTPTTRKLFTKPIPYGSLPSSGALLCKVPDGSLANRSSSGICGMSPSFSVTLSEAEEDTTLMSAESVFASASVDQRVPLRSASFAVNETRPPSSPSFTYFPSSHGGVAHESSASASDKANAAGAAPVACFYNAHSVCDGRAPSVKGSSATEHKFFEPLRFDTSGRLFSPLQRFSSVKSSQHANVAVDLESHILDCGIASVDHENLSAACPLSNMWQGRLSAIVKQQQLLHACLVSIARERTERPDSQRSVISTPKCAQQQRRRGSRLQFLMWQLCILLLRLTLRIMERVLAASAGKLRKLLCLPQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPL6</accession>
    <name>A0A088RPL6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_171060</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12 13">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697797.1">
        <property type="nucleotide sequence ID" value="XM_010699495.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22573849"/>
    <dbReference type="KEGG" id="lpan:LPMP_171060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170016900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_171060"/>
    <dbReference type="eggNOG" id="ENOG502S2P9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="429671at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF758">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="557"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="408"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="472"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="627"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1317"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="422"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="479"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1317"/>
            <end position="1326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN97144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1337" mass="144249" checksum="01349EEE0BFA8878" modified="2014-11-26" version="1">MSHGRRMLEAQAQKERTSGTHEDGRLNDGHLRNGSRSLNDDGTPVRLPRGSAGASSGDRRQDGGHDDDAALVSPPPRPNVRLGLHHAGDGSSSTTSVATAVGRARGGSIAETTNHQPRIRDLGPSAAPLSYTPLAVPRRLQPSDVAEGMHVSAARHIDVDAEEGEADDNTRRTNNTLAEAAPRGSRRRRGGGTRDDSLADGDSAQRRLSCEPCNRSRSRTGGSGHSAPSSLRYPASRVNVVAVTTTPSVAPCDLSSPPSRSRTESRSPPLMTAAQRASASPSHQPRAAPLPVPITATLARASKGEIGADSTLETGPEASVAHASRQPLPLRPEPSPWGGGGAGFTTTATATVPPPPLQRLMPPASPPLRAGVSPRTLPLHPTRADASCASMLISRATSASTATTTVVTTPSSQVQLPPPVGSQVSPYELQQHQSHPILPTPLSTSVTGVPSRSMLQHSVGDLTGEAVEEDHIASERESQNVLRSSSPLSQKSEPAMVTAGPEWKSAPPSPLPTVTEPLACPRLLLLPEATAPYDEMGIPSLRNRVDRCIYPFMRDFSGFHNTGNDCYGCSLLTMLLRSAVFRRALLVSPLVCAVRHYEALLTGKAERRVLWTSGYVDSAAETKTKKTAVRKRARAAGRSAEDGDDGQTEEASVAVVCDLPDTTPMEPVEKLAHSQYVWCPTADVQKTLDILGTFSLDELEDVLEVDLTTQRVPLTLHGALAALARAQRWREHLTAIVNTPHTQAAERQRLLETKIYHDNDHDFNGQVYTYGIRLTAVANLFDGDFFLGDQEDAHELFVSIMAKLETEAVRFQQQCDKILERRSSTNPNGEHNMENEVDEKLESGAKETNDANAASFAEQRLQHVAHVPFVSFVSPSDVLTAASSPVQRRPSVSTAAAAVWINTLVQTRLLNIIRCRTTGCHHEIVTDEVCVNLSVHIPEESPALPPSAPPSLPPSCFPALPPPLLTTSIFPSRSTAAAATAAAPQSAVDGGGGRCRSIAHLLHDSMAYEALNDYRCDGCGSRTSQFQGGCFYTRPPSLLVLQLKRFATQFVNGTVIIQKNGRRVAVEDTLVIHALPSAAESLVWQRRWERQHHLSPGCVVHTEMARAGEDAKVEHRASPATTSPCEDGTCCSYYDPDRKCFSDAMQKACYASEGHESAGQDSLKYYTHHGTDDDLPRTTASAAPSSSLVWAIRCVYSLRSCVLHLGQSLHYGHYVSDFAVDGEEDGSDGETARERCTAEEEAGLEAHSQTPLNFRTAGRRRWRRANDERVEVLSEEVAQARRTGCSDAYLLLYEKVAEERVRCSAEMVLPTPIYRSSDESKARDEAGELSQLQATKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPN0</accession>
    <name>A0A088RPN0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_204290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698630.1">
        <property type="nucleotide sequence ID" value="XM_010700328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPN0"/>
    <dbReference type="GeneID" id="22574640"/>
    <dbReference type="KEGG" id="lpan:LPMP_204290"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200049000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_204290"/>
    <dbReference type="eggNOG" id="ENOG502SAXS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="257944at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="203" mass="23000" checksum="AF292A2771E8878E" modified="2014-11-26" version="1">MLSSGTPLHGVEWPPSLLFTVKRHLDHVEDAVRPSIPPMPSSAPTIYDFFEVHHDAIGGEMLRSGFDAAITECCTAFLMGVLEQSCSLSFLLSRERRIIAMTVRQVEKRLLSKGRSNVMDSKRRRLDEKAASEPRYARVLTLEYLLRLYVSLPMILEHYNKLGSASMPSYATAPLWCFINITMRILSADPQLFSPITQYVPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPV7</accession>
    <name>A0A088RPV7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_203760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698577.1">
        <property type="nucleotide sequence ID" value="XM_010700275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPV7"/>
    <dbReference type="GeneID" id="22574587"/>
    <dbReference type="KEGG" id="lpan:LPMP_203760"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200043700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_203760"/>
    <dbReference type="eggNOG" id="ENOG502SB5W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271171at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014848">
        <property type="entry name" value="Rgp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12507">
        <property type="entry name" value="REDUCED GROWTH PHENOTYPE 1 RGP1, YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="52051" checksum="A9EB9F871B1ABD14" modified="2014-11-26" version="1">MDFSLTMSAAPHRLWYIAGDMVKVRLSLTCVPEVAPDTQTKMTPLKGAPNHNHFSVDSSAAESHETDVRVGSLRVELVGLVELDTSVMKPINWPAAVSEKERPGSSHLGSSRYKMVYTLYSTGKQMLREDMQLKRYECAALEFVFRLPEGSPPTFKGQGADYRHDITIFATWYTVRSSSTAKATLPHLCKAKVPLTVFNSISTVAQLPLMSLFPLPPDSALVAENFHFQVAPLDTVPTPWRAAPLADVMLPQEAQLRTSLTVRYSAKARMQSSLATQRQPLSLMVPCLGVNILQVDLHSSCVSLGGYLQGSFTVLGTSQRPSNTTAGPGTHRQQDVEAPVPVSVSASLELLEYVTPESALVIDNTSMTDAREGGMENFACTYRRVIDHAQFCVVDTPYVPFEFPLPVGPVPASSITDITSFLWQLRVVVMVVSRKTLAQTAAPGVSQLGPLLSPVAAIFPLLVMPPSVPSKVRQGAAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPX0</accession>
    <name>A0A088RPX0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nuclear transport factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_210460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698834.1">
        <property type="nucleotide sequence ID" value="XM_010700532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPX0"/>
    <dbReference type="GeneID" id="22574868"/>
    <dbReference type="KEGG" id="lpan:LPMP_210460"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210009200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_210460"/>
    <dbReference type="eggNOG" id="ENOG502S1DQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="250271at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00780">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000035">
        <property type="entry name" value="Hypothetical_protein_-_conserved"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039539">
        <property type="entry name" value="Ras_GTPase_bind_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10693:SF20">
        <property type="entry name" value="AT27578P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10693">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="NTF2" evidence="3">
        <location>
            <begin position="22"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="247"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN98127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="417" mass="47429" checksum="357A05E3ABB3DC16" modified="2014-11-26" version="1">MNNYPTAMSEQQSLAPETAFTVASTFLAYYYSEFVKLNELARMSDLYDERSYMTLVDFRDEVPVVAHGRNAVANLLAKLDSTLGQRKVEIITVDTVALPHNCVQVICQGVMYLREYRRVFLHVFMLEPTAYRTKTYHIASDYLRFVDSEKEVIPEGAVVIAADQVAAYLEESRRHIEEEQRRQLLEFQQRIRLQQQQLMQQQQQKAAATMSIPAPTSRQNRPVASASRDQPHTQEQQQQQQRPARPARGENQRELYGERKPRESRGERKPRELREPRGERKPREGEEKNAAVSPPRSVGEGKRGGERGNRKPAPAPSAAKGTPAASPAPAAERKPRRESGPTAAIIMLRVPKKIKLSDIKAELVSQGFSEPKDLFWCGRDSAHAVMKFSAVEKATELFAKMLFTIQGETLKMDYYHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQ27</accession>
    <name>A0A088RQ27_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mitogen-activated protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_190120</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698007.1">
        <property type="nucleotide sequence ID" value="XM_010699705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQ27"/>
    <dbReference type="SMR" id="A0A088RQ27"/>
    <dbReference type="GeneID" id="22574066"/>
    <dbReference type="KEGG" id="lpan:LPMP_190120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190009500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_190120"/>
    <dbReference type="eggNOG" id="KOG0198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06606">
        <property type="entry name" value="STKc_MAPKKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000888">
        <property type="entry name" value="Mitogen-activated protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF56">
        <property type="entry name" value="MAPKK KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="12"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN97354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="280" mass="30742" checksum="8917647D1690A297" modified="2014-11-26" version="1">MAAISTKELMDVTLGKKLGAGSFGSVFVGVLPSGHFVAVKVLELSDDAPSNTEVEIHRKMVHHNIIRYLHSRIDAESTPKKLYVYLEFVTGGSVTSLMKSLPNGCLPYSVVRVYARHMFQGLEYLHSNQVAHRDIKGDNVLISMDTGTAKLADFDQAKIMNTHGTLRKAATATLAGTPYWMAPEVITDEDGYDPFKADIWSAGCTVAEMITGRAPWTPMPNVMHIMNKLALSTGWPDAVPKDATALGSKDAYDFLDLCFQRDVSKRPSAATLLKHVFLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQ69</accession>
    <name>A0A088RQ69_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Actin-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_210270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698815.1">
        <property type="nucleotide sequence ID" value="XM_010700513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQ69"/>
    <dbReference type="GeneID" id="22574849"/>
    <dbReference type="KEGG" id="lpan:LPMP_210270"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210007400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_210270"/>
    <dbReference type="eggNOG" id="KOG0680">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6220758at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000100">
        <property type="entry name" value="Putative actin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="312"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="595" mass="63844" checksum="5172EFBEDA55CA0B" modified="2014-11-26" version="1">MPRVQLFIDNGGHSVKALYLPASTGTGSRAAATHTLAHTSGPTHGEAAAPATALTPAPKWLVVPNCVGAAVYAGTGIMGDQLDHLPHYHGLMVRRPVDRGFIVDGGLQTRVWEHVLQHFAIESEEEVDVWLTVPFAAPKAAAQLLWLLCTRSFHFGSVTVVSSSFMSLIAYTFARGTLTLSSAARKRPRGAVDIDAGESHDSGNNVTSGGTAVMVDVGFSATTVVPYVNYMPVHSSIVRLDVGGKVLTNRLKEYISFSQINVMEDTWLINYIKERCCIVARHPRRSLQRYAALREGKSREEVEAIAATATALRRGSGGGDMQSPGSQRPDTPAVGASTSPDVPIRYYLPTIPALLPLGVLEVELPSRLPKTSGVDMEALQHLLLCQERFLIPELLFTPADVGIDQQGVAQAITQGIFQRGLLQHLTELLRPLLLHNVCVYGGTATQPNFCDRLEAEVAAVAPQYQPGGADLDSRECNRSTTRISSRGSAAEISADRVSCLSAAPPLPEFLSKSSAAATDLSLLPLLGAWCLLSATASGVANGTATADNQGNTGAPKRELQRLRALVHQRSRIELQHPPAGRVTVETFQRALERML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQI3</accession>
    <name>A0A088RQI3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase regulatory subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_200070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698206.1">
        <property type="nucleotide sequence ID" value="XM_010699904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQI3"/>
    <dbReference type="GeneID" id="22574214"/>
    <dbReference type="KEGG" id="lpan:LPMP_200070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200006300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_200070"/>
    <dbReference type="eggNOG" id="ENOG502SGVD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="64214at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003117">
        <property type="entry name" value="cAMP_dep_PK_reg_su_I/II_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02197">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47391">
        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIIa" evidence="1">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="90" mass="10073" checksum="AE66536CC8B42BFE" modified="2014-11-26" version="1">MADHATAALMAEPTLKEAAAAVFNEEECTALKANLRAEQIAQAKYLRAHPEIHKAVQEGLARVLQSQPEDPVTFLTQYFLSEEFLHQRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQZ7</accession>
    <name>A0A088RQZ7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inositol 5-phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_201300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698331.1">
        <property type="nucleotide sequence ID" value="XM_010700029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQZ7"/>
    <dbReference type="GeneID" id="22574339"/>
    <dbReference type="KEGG" id="lpan:LPMP_201300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200018100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201300"/>
    <dbReference type="eggNOG" id="KOG0565">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="62798at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF300">
        <property type="entry name" value="TYPE II INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="207"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="555"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="772" mass="86507" checksum="371ABF4B0B53DE76" modified="2014-11-26" version="1">MKTPTITPAQQWQEEEAPRAPLWARAAVITIEVIIWLVTLGTVKRVAALETLLHYSPHWRKRDRAEESIKGILRSGVGAARRLARPLLRIETEFLTERSINDSGGALTPRTATVYEETIKTRQQVNARIRSCLRDVAVDDLQVPFLVNACTWNVDQQAPPVYEDAFLSWLIGQELTDEVKQYQKHKQAVLANGGSPKKPLYLSGSSTMRSRKATTIAGSIEDSRSCKNTTTEDFYLADQKRAAAILDSEWELLEAKFPDLFLISLQEVEMTGTALVKESTQRSWEWVDAIIATLAAASDRIIDYKKVQVVQLVGLVLIVLVQAKHVDYVSHVRLSLTRTGALSVLGNKGSVAMRVTIYGKRFLFISAHFVAHKHNEKRRRRNYQAALKDIRFDMPVWSDDESEVLQTFLNAKEVLNNSIDNSSVRGNSAWDRLFNLGHSAFRSSLTTAAETRVLDDHDYVFFLGDLNSRLHGLSGPLIKESVRRGEYDSLLCHDELRQLMVSGEAFDGFQEQCISFPPTYKYDRGTDIFDTSRKRGDPAWCDRVLFRVLESDAVPATSQEERSTEEVKSPASFDSPQSGLKCSQLPRCDSMTSGMWMSLEEFEYKHLGPNAAAVARAAFARSSSSTSSEDVASEQSLPRELEDTASAMSTVAAQNKLDSADKVLQCSPVSLPHRALPHAVWEQKRCAPTFCAARRPRCVLASSSPSSFVEGLTTPTRFPMVTNHVHPLEYTYVPSLRQSDHRPVRARFEVKVISMEPALVSRIVEEVQQVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRK4</accession>
    <name>A0A088RRK4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">DNA polymerase theta (Helicase domain only), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_231540</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699310.1">
        <property type="nucleotide sequence ID" value="XM_010701008.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22575359"/>
    <dbReference type="KEGG" id="lpan:LPMP_231540"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230023400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_231540"/>
    <dbReference type="eggNOG" id="KOG0950">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2320933at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18026">
        <property type="entry name" value="DEXHc_POLQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.20:FF:000004">
        <property type="entry name" value="DNA polymerase theta (Helicase domain only), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000813">
        <property type="entry name" value="helicase POLQ-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046931">
        <property type="entry name" value="HTH_61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048960">
        <property type="entry name" value="POLQ-like_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF6">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20470">
        <property type="entry name" value="HTH_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21099">
        <property type="entry name" value="POLQ_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="1245"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="1500"/>
            <end position="1741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="113"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1161"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1824"/>
            <end position="1850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1885"/>
            <end position="1917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="126"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1169"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1886"/>
            <end position="1896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1904"/>
            <end position="1917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIN98603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2239" mass="234581" checksum="673DD1FFF64C861F" modified="2014-11-26" version="1">MRRSMMTTRGFHAPRPSGSHKPLADNTASSSNSAAPPPPSVSTSFKASARGSATAGASSSPRRRSSDGGRKMSATTAATGDAGVGPANTTISPRGGCFSSLQAPRGLLSGHFSANHRRRISRRDTQAIPPASASTAATAARAPADTTTVVTAAAEHAAVPTSRDDRVATLGSGDTSLRCKRPRSPFLDDSHVGGTHDGDEATSPRSRATSTRSNSVGDKSDDATSLAQLRISRLPTARRFSTSHTPRTVFYPPSSERPVEFLRSSHDADGDGTMGAPESALEPRVSSAPLAAGVHVTSEHTLHVHPWGSETAVLGGTGAGDALTLAPTTGTLWVPGSNPAVCVDREQCSSTTPVSEHPMTPLSAVMTAPRTTPSSTQSGERFLSVLECQRRNDATALTTVPPSLPSLSLPYRSPCCTSASQLVSSAPPAVPSISKAAPSVPPSLSLPLLPCGPTSPLPAVPQLRVCNFDAPSFSSPRLERAVPLPSPSFVGGTLSPAIGLMPGQAGTFAAAAAAGGSERQSLLSLAPPASVLDKLTCVPQQQEQQAPMIPFYALAAAEEAEREECDEVLERETVEDLRMSTDIAFTPSVTGSGAPPLFSQSSMIQEEEEQATEEGGEAAVCMMRGRAVVAERADDNSGLHSGLMISGQEGDACPVFRFQDDAAGQLIAGSPLSPRPVVPGTFDQHALLSCGGCGGGTAATDLSGVTPLSSSAGLFSPFTGPPSALSTWPIREATPPRFPAVSASGAGLLPLSAVASGGSGDLSVEGLGRGRHRTMFSFSSLRAGTAAASPLPGPLAVPPACLLQSPVETAVDGLRANARDVVVPAAERATPAVRLPSSEACTTAQPPDQRLPLTLAAARVSTPRDSLPLLVVCAGAKGEECIPQGASPTGIVAPTSTPLPWSDTLAPATGFPTLSSSCSTVPPLSDSYAAALPCLAAAPGSSSATALPARPGRTCFTLHSVESVTATSSFSATATAVAKPTTAAAVAFTGAVPPGHTEAAYLPSVSCSTGSYSAELQQLPRRCSVPPRGTAVLADSAEGATDATPSGATRVLSSMESSDTTVCAQQSVTKAHPMLFLPMDSVPATVAVHRTPSASTSEEAMGNRGNFTLQQSQLPLPTAAVTERQQLWSSYNNNHPPASFTVTTVSPFVDRINAEVPSAMAPQSAEAPTVHDETAQSHPRESKGMLFSSPLSPSQLPSLSLLRPTAAADDPAELFYDLPREVGHFYATRRSITSLYDWQHDLLTLPEVRQGGSFVYSLPTSGGKTLVAELSLLRCVLNRRKSCFLVLPFVSLAEEKTMALQPLTAAFDFNVDGHYGSSGRFPLCQAPAIYVCTIEKANSLLNHMLEEGRTEEIGAVVVDELHMVGEPRRGGTLELFLSKVLVINAMRQRQRDFVAAPASQGRQSACDTAPGWPEELEGVEEDLHETAVLTGISRAAVDPGPLQIIGMSATVPNLRTIAEWLRAVCFECNFRPVPLHAYSVVCGLVLRDGHHNERNLSGSSTTQHLLELATEVPDASVLIFCASRQQCVDTARGIVNYLKAQAIASQKIPSAVMTGCSDVTVEAQHVSALGVPFSSLMKGQAPAAAVAAVPPQASPAIKSLLADLEALTHYEASQLSEVIPFGVAFHHGGLLAEERDLIETAFRRNHIRILCCTSTLAAGVNLPARRVIIKTPYVGREFLTKSRYLQMCGRAGRAGSSTYGESFLLLSSRDQARGHALMRACVEPCCSQLLEDNQTFTRSLLECVGVGLVVDRQSACQWSESLLSRWAVGPVDTVWQPFIAAAATSSASASSKGAFPTAAANGMRGSAADLFHASQLVYDDDTVAAQSSEGSRSAPGPPAPLPSQSASPSLPSLPCVPPAAMNAMVRASLATLARCGFIRIVDARSDSSSSSGNDIRSVTDTRADGSGSAATGAAAEKTSGSASSAALEALLSRVFDDSHADASAETHNACHVQVLVTPFGSSSVRSCFSIEEALLLRDELDELCHTGLILSDDLHLCYFLTPLREVGKCDWELLRLMMSRMSDSRQRIASLLGVDAFFVDQQAMGLGGPLEATDEGRRRLFTAKRFYVALMLADVLAEVPMATVEQRYDVSRGQLQNLMRSASMFSSSITSFCHAMEWFSLEAVLSSFVKRLGFGVKPDLLPLMEVRGMQPPRARALWNAGFKRLATIAAADAEDMVSKVKAMNPKDSKAAKFFTKRLALMTIREANLTLQSQIQEKKGELQELAVRWGGGGVGLRGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRN5</accession>
    <name>A0A088RRN5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_241340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone deacetylase family. HD type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2"/>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699474.1">
        <property type="nucleotide sequence ID" value="XM_010701172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRN5"/>
    <dbReference type="GeneID" id="22575543"/>
    <dbReference type="KEGG" id="lpan:LPMP_241340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240021300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_241340"/>
    <dbReference type="eggNOG" id="KOG1342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09991">
        <property type="entry name" value="HDAC_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000029">
        <property type="entry name" value="Putative histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF10">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="396"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="420"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN98767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="433" mass="47473" checksum="E32506B84E4D4405" modified="2014-11-26" version="1">MRPSRVRALHALVHSLGLDDAECMTVCHARPATAEEMGTFHRGAYLECLRQAPVICGNPLDEMSLAFQKEFDVPFASQEGDCPLFPEVWSLVSSQAGASLACAEALLRGDATVAMNWAGGMHHAAAAHASGFCFVNDIVLCIRRLLRHYQRVLYIDLDVHHGDGVEGAFYGNHRVMTLSLHQFGNGFFPGTGDYPTRETADSFAINVPLPTRTGDAAYLLSFRTALSSVVQCFDPEAMVVQCGADTIVGDLIGRLCVTTLAHTQCVANVLSFERPTVLLGGGGYHVFHTARCWAIHTATALGRTAAQLPLYIPRTDPYYMDYRQECTPKRPTLHVFLDPDVDDPLPLGDSLAFWRQLCLSIQWQMRTARLVRQGFSRTVQLCRQRRAALLRQFASQEAGKESGVGVSGPKRPRSAATTDRSGEEGAEDRVFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRQ4</accession>
    <name>A0A088RRQ4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_241650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699504.1">
        <property type="nucleotide sequence ID" value="XM_010701202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRQ4"/>
    <dbReference type="GeneID" id="22575574"/>
    <dbReference type="KEGG" id="lpan:LPMP_241650"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240023800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_241650"/>
    <dbReference type="eggNOG" id="KOG2807">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="284275at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000112">
        <property type="entry name" value="TFIIH basal transcription factor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007198">
        <property type="entry name" value="Ssl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04056">
        <property type="entry name" value="Ssl1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ssl1-like" evidence="2">
        <location>
            <begin position="8"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Ssl1-like" evidence="2">
        <location>
            <begin position="135"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="438" mass="46819" checksum="F9D1C9C45DDC742E" modified="2014-11-26" version="1">MLRTVLLLDGSDAMNSSSDYLPNYLLAMRPPLLRLVEGYLDSTPLASLGVVVMRDGISHRLLPCTTNHNEIVDVLERDVFLHGGSGNTSMENGLRMAMSELVDMREVAALVSTAAKKSSSIAAVNPRSAWKGSATQLNVIVLTASVTLIDPTDVFAVVNVMAALSIRINVVSLVGAVHVFDVCTAETGGTLYCPLNYGHLLHIVDELSAATSLVRNKKHQRGGRRQRVKRSREESDDVKADDDDNEIPHLIPIGCPVYLEAPPSNNAGSSSTASSRSFYLACPQCHLIQLSIPTTCSMCRLLLCNAPMLYSTFVSHNSLVPPAKSLRVVRGTSVPAPIITTLSAAPVPTIQNDGVVKTTTQQPVRCDLCMTNILAKAMVSHIRSGGVGSPVASSAAAASVVDESLVWQCSACASYRCNACNDFVLRKIGLCPYCLALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRR4</accession>
    <name>A0A088RRR4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_231400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RICTOR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699297.1">
        <property type="nucleotide sequence ID" value="XM_010700995.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22575345"/>
    <dbReference type="KEGG" id="lpan:LPMP_231400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230021900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_231400"/>
    <dbReference type="eggNOG" id="KOG3694">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271111at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028268">
        <property type="entry name" value="Pianissimo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028267">
        <property type="entry name" value="Pianissimo_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029453">
        <property type="entry name" value="Rictor_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029451">
        <property type="entry name" value="RICTOR_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029452">
        <property type="entry name" value="RICTOR_V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13298">
        <property type="entry name" value="CYTOSOLIC REGULATOR PIANISSIMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13298:SF11">
        <property type="entry name" value="RAPAMYCIN-INSENSITIVE COMPANION OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14663">
        <property type="entry name" value="RasGEF_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14666">
        <property type="entry name" value="RICTOR_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14664">
        <property type="entry name" value="RICTOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01303">
        <property type="entry name" value="RasGEF_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01307">
        <property type="entry name" value="RICTOR_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01308">
        <property type="entry name" value="RICTOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01310">
        <property type="entry name" value="RICTOR_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR N-terminal" evidence="4">
        <location>
            <begin position="168"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR middle" evidence="3">
        <location>
            <begin position="668"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR" evidence="5">
        <location>
            <begin position="1318"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="475"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="488"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN98590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1538" mass="167786" checksum="CC8750E4D9F412FC" modified="2014-11-26" version="1">MATANMRKEALELLQQYAIDLKDFTKARARYTTVIQKELIPLPQEESNGDVLAATRAAQEQVRAAWEEYITSVQQYFNRILRSTLRDLLDSGGSIATASTIASTSDVLMTASSKDRLEATLGPHVATTSTGSLDPGWVSLSTSLVNIPVAGSGGSVGGDALAQLSRRAERMSDFCAFCEKWYVGNEAVFELPESEALAAFAASSVASVSRLLRLLGMRMTCVCAGSSRFLRRFIEDGEAVRWVAFCGDRGLNAEVDALLSLMDRLIQLNIIDSKAYPRVPFGWFYRLSSLLEHPDSVASASPKRCSVAVRIALQLLRHEPDRATAAGLHSILLKACIEANGCVTPDEAQQVMRTFLNLFDDPSTRQYLKPTDLRTIFAPFLSTTESGGAALLTMQNNAKDLIVAVFSTWVGNLWISSEVTGLRSIIDVLHLPGSLDTKMVIITLFNKLLTRLAPHRGIVPMDTWKGFEEDRLRKATRDAKEEQTIEGSDGGGEGSGGDVSNDTQCLNNNSFMYDLFLADSTGDAALFDDFVPTTKALGYHVMDPLLGRVLICLNYHGLPYALTQLVQVVNKNRVITAAASRLLQDIFVLMDTVLPQVIVFKLHEAFNKAAGHLTNDDSLFVGGLTSQLFRNYKKSSGIGVSDAMVPVVPTNTAQMPSTVLNTPGTLDVDDPTFTTMLHDCKVDRSKSCHTWNFDILVTLVQGPLRLPRRFRAARELVESLVLFFTPSSGSSTPQICSTFSALPPDTVSPQVCMVGVELIDLILSSRDGAVLLERMGFVAAVAAMLKEVRIGKPVVLRRAVVNACIGRSLLRITGRLSAHANGLLLMRDHGIFSLVDSMFSKLKGPRLESPAEEDTLHDVCYQLLQCLYLGAVPNYGVCKDIRHTFRAALGNPSNSIRLCAAQQLKKAVWRDLSTSMKWGIKTLLQSLHDNFFSVVQSAFKLLLSICLCSDEGLDYLIECFPTVLMESEVILSHAKQLRLNVLLYRIASRPSGFRFLQCYGWLEKELHRWEESESVQYTIMLERLQGSDGSSAVAGGRGGAGSMVMPSTSDPSCRQSQSFSDTLSVMYGCMAGSTPYLSLLTAADASGTKFFPVHFASVLCSSVEGCAMFKHSKLWTRSVQRLLEQPLPPDVVFDDFLSNEDDSSSNDRSDDEFGVTTDATRYMYQQQQAQQWQQQQQMHPGMNTAYYSSGIGGVGGTSVPALGAFANSANVPRFSVAGDYLVNSMSMTHRARDGPRGGPSTSLGNNNIVGGVSGNAGAANGNFNGGFGGVGQSTIATAKEIEMLKKGYFSAPSSKMISASRFCKSSCQSFSLDCVGDIVALKDAILCIAEVGSTEVGYGMLLSVPGLQRRFIALSRFASTISVRCMALLGSAILARSRRGGDDLVKKGYSVVLNPNAYVSAEGIPYSVAFAQLKTSKWVSIACRAAVSNTTARHAHADSNVFASTQEIPQRIVDNVYALSNPVSCENAKKMLYKIMKRRPQVFLQPQVRRLCLDVGFTYRMHYKERRFLADLLENAQLNAGTSTNTRHLRMPLLRASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRT7</accession>
    <name>A0A088RRT7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_204600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698661.1">
        <property type="nucleotide sequence ID" value="XM_010700359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRT7"/>
    <dbReference type="GeneID" id="22574672"/>
    <dbReference type="KEGG" id="lpan:LPMP_204600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200052700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_204600"/>
    <dbReference type="eggNOG" id="ENOG502SA7B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271837at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839062" evidence="2">
        <location>
            <begin position="29"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="303" mass="33963" checksum="EFD0FD6ACC047D79" modified="2014-11-26" version="1">MRDLSSRGKTAVLLVALLALLGTKGVQAYSVRYAGKVSLNGMMNFETVGYCGQDDSGHSMMPKLQSYQTSAAEVLSNNNFNTAPIGGESRQSACLDANCTWQFNHGLHYRNEITFYYGVVYKDNLLGGPADGIYNNFASGQPVWWSNVSYWGGRQPYMMSGGQWANGNVVTYFTQWVCEYYEYQLSDASIFPTYPDGQVITPHFAGNYYHCDKVVERDSQGRWIYQRCKEPFPWWGGLVIAIVSLMAVVVIIITICCLSFGNERRKIRKERERKLETLADNPAQVPNQTQVGLGRTPAHCGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRZ2</accession>
    <name>A0A088RRZ2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_205170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN98009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698716.1">
        <property type="nucleotide sequence ID" value="XM_010700414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRZ2"/>
    <dbReference type="GeneID" id="22574729"/>
    <dbReference type="KEGG" id="lpan:LPMP_205170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200058400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_205170"/>
    <dbReference type="eggNOG" id="ENOG502SFCT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267774at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="709"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="486"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="641"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="676"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="728" mass="76113" checksum="B6A6271A465498DE" modified="2014-11-26" version="1">MELHPLEAAAVRILFCGRPALTTGVVNLRVLLGGDGQYCLAEKRKAKLHHSSRHCTGGNVSGSNSFEIGGDAEEKRESVYRVCSSDGLPDGCYYVKADRHYWVMHVKEEPRVAFAAAVATPTPPSTSVSGTQVTLVSPPMPLATIASTAEHSKVEEDELTSYKQDGGSAASAPAAADAMSGTAESSSALIPAGDAGCASTESKRQRTISTKRKCTRRAKAVEEDVDNLPLINTTFFNPTPLAEASPLEEHPQQEGASRHTVSVVGDVKAMQREKLLDIPPSARPSATVAADILVACEELQSSQQQLEQQSERRKKTSRVHVDAVAEEGKDNETATAGSCVSTKRARGGGNKANGNAVGGAPPAEQLAELAADSSQPTKKPQQRGKRCRNNDLTAEESSVLPPVWHPSDQPKSFLSSSTEKSPLPTPKTTKAAQKNKDLRSDEVEACASASATKLTDAGPPLLSTITNRDTESAPTPAPPARKSRKSSAATSATSAAATSDAAGTATLSKIPTPPPSPPPLHSVPSAGHATHGLEQKTPSRAGTNTASIVPSPQQQVANSSAIRSPASVPQDTTPDVLYSNRSSDGHAEARRSTVSSIAAPVTHPKLRQQWQSQVQQHDHHSALNSPSTRSQPGANRSASTSSLLRPLPSPLLQRQSPGSDISGGAAGSRGFHEGAMNGGGGGGGFFPFDSPALGFTQVHHTLAEEFSLDVSESESSSAASEYLCDVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSE7</accession>
    <name>A0A088RSE7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_250330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699605.1">
        <property type="nucleotide sequence ID" value="XM_010701303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSE7"/>
    <dbReference type="GeneID" id="22575681"/>
    <dbReference type="KEGG" id="lpan:LPMP_250330"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250008500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_250330"/>
    <dbReference type="eggNOG" id="ENOG502S6JV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273256at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="696"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="935"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="698"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="963"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="993"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1031"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1048"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1073"/>
            <end position="1082"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1082" mass="117459" checksum="B0B80C0971A8E339" modified="2014-11-26" version="1">MWGGLEFFVSIEVLVSFSIPPSLCRDGASSVTSASGDKALAIKRAGNPTVRRLHFTRERRLTSVFAFPNATLFLQVLFSSGNKVHLITPWDKEDTTTILKSFGWVSFLADARHVSVVPGSSQFGFSSLGVDPADYTRVVLVVDDASRWSSATTLQLIEVRHTSEGQDVADSMELLYALSRCILFSEWYLRYPSSCISSCTALSNTTVFAFCRFFLNGPRPDVELMQLICYHGGRIVRSATEATHVLILPSPPSEHGTSSSASSSSTASSSTSASVDDSGSEGERSDSLVDSTDADTSDEECGNDTSVPPQKSGERPLGDSGARRGSLDTPVSDTGAAASLPAPRPSAASPQRPVAGCSSEALVAATQLSSVASLPATNVPSQTVMVTPSWVYRCVRGLRLVPIECEQATAAPGAGEEEEEGQGKLEGGSKTEVVRTTGALLCALLPPADARPLLWTTLHSIASQHGYDTAALVQGTAAAVPLKTVTAACVLEALTSRVYSDVVEVRLQPLPVAGKSTDASSISSRSRGVPVTRRTLDSQRLSTGSSELGRIALHRFERRRDKEAVFSHLQLVASQFLYSFDYVQRQRSQALHCYAGTQTSGMRHASMGTMTEAQPPPASSLLAADKELVESKEAAAVVTSDTRVEERESASLSAMTVAAKAAESSTGDTAGAVGEGEWRHHLRNVEGKLLISHIHANQMRDEEAEKRSRDGSRHTYGADDAEDPTKSVRALTAQLIEHTEKTELSTIMIEEDFTLAPPCSPKIVTESSRDEAPLARPPLAPSLLKPPSLLPLPPMAKLINDGRGKADASLTEFTACFIPTSVLTTEQQYDFYVFLCSLPLFDTAELGNSVVRVADGVRCQFANHKGANDFLRIEFIEFLSLRLPIFPATEDSLDVEDLQKTIMDFPFLHLPTTPEVSHEEAKSLWTAPVPPEATAFASSPAARLRTSYSSDMSRYPRRRETRSPSAGSRSPANRGSDSSRASHARPHIPQSDPRTDSRWKRDRDDGNEKEPPLPADHYRQCDRNRGDVHHGSSSRCAESSSSSHRHHRCDDHGDRHLSSRDDPDRNLRSSERHRLHSRRERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTD8</accession>
    <name>A0A088RTD8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribokinase</fullName>
            <shortName evidence="9">RK</shortName>
            <ecNumber evidence="9">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_270410</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-ribose + ATP = D-ribose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="9"/>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700129.1">
        <property type="nucleotide sequence ID" value="XM_010701827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTD8"/>
    <dbReference type="GeneID" id="22576217"/>
    <dbReference type="KEGG" id="lpan:LPMP_270410"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270010600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_270410"/>
    <dbReference type="eggNOG" id="KOG2855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="415590at2759"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000102">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="Ribokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584:SF166">
        <property type="entry name" value="RIBOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 9" id="KW-0630">Potassium</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="10">
        <location>
            <begin position="17"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="25"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="53"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="245"/>
            <end position="250"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="277"/>
            <end position="278"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN99422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="329" mass="35315" checksum="34540F702F885951" modified="2014-11-26" version="1">MHRAQNVQSHVGTYAPDILVVGSCFLDYFGYVDHMPQVGETMHSESFQKGFGGKGANQAVAAGRLGAKVAIVSMVGTDGDGSDYIKELEKSGVNTAYMLRTGKSSTGLAMILVDIKSSNNEIVICPNATNYFTPELLRAQTNNYENIMHPGLKYLICQNEVPLATTLDTIKEAHRRGVYTVFNTAPAPKPDEVRKIKPFLSYVSLFCPNEVEAALITGVKVTDSASAFRAIKALQQLGVRDVVITLGAAGFALSENGTAPVHVAGKRVKAVDTTGAGDCFVGSMVYFMSRGRNLLEACRRANECAAISVTRRGTQLSYPHPSELPAGVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTF1</accession>
    <name>A0A088RTF1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Thimet oligopeptidase, putative</fullName>
            <ecNumber evidence="9">3.4.24.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_261550</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.15" evidence="9"/>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699975.1">
        <property type="nucleotide sequence ID" value="XM_010701673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTF1"/>
    <dbReference type="MEROPS" id="M03.011"/>
    <dbReference type="GeneID" id="22576058"/>
    <dbReference type="KEGG" id="lpan:LPMP_261550"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260021000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_261550"/>
    <dbReference type="eggNOG" id="KOG2089">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="534666at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06455">
        <property type="entry name" value="M3A_TOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000074">
        <property type="entry name" value="Metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF84">
        <property type="entry name" value="SACCHAROLYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="8">
        <location>
            <begin position="150"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN99268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="607" mass="68800" checksum="33120F730FE780E0" modified="2014-11-26" version="1">MASVSPSKEVRDEANKCVVELETFAIDNFESNRKLYSALKEVCAAPAYKAEYANGKAPRECTYWMEEQLADYRRKGMELPEEEFQKVVQLQKELTSLCTVFQQNISEDKTEVYFSMDALKGVPESVLSGLPRTEAGECTLKMDYPTYHAVMKNCEVASTRQVMARAFTNRAYPANDKVLRDIIEKRHQLAVILGYPSFAHLYISDKMAKTPETAQVFVDELIPKVQKKWAAEAELLKKHLHPSCSLSPAGEVQAYDVPFMINQIKKTLLNVSETEIQEYFPMDATVKALFDIYQSFFDVTFLQVDNGSELWHSDTKTLEVKDNKSGCVLGYIILDLFPREGKYSHACCHSVVPPVLLNEGGSDFSPALAVVIANFPAATAERPALFLHDDVETFFHEFGHAIHSLMGRTRMATFAGTHVKRDFVELPSQMLEEWLWEPEILQNITSHYKTKEALPRALIDAKVASKNAFSGRDTLRQLQFATYSLQIFGLPFSTQPHDDLNTTQLFYDIEPRVMPGLSYEHNTHFESAFGHLTGYAAGYYGYMWSKVFALDLFEYIRSRNGLLDPKMGRHYINCIIGVGGSQDPNDMLTKFLGREPNNEAFLRNIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RU34</accession>
    <name>A0A088RU34_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_271530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700240.1">
        <property type="nucleotide sequence ID" value="XM_010701938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RU34"/>
    <dbReference type="GeneID" id="22576331"/>
    <dbReference type="KEGG" id="lpan:LPMP_271530"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270022300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_271530"/>
    <dbReference type="eggNOG" id="ENOG502QRIZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272026at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="744" mass="80085" checksum="2F37127A0E220D58" modified="2014-11-26" version="1">MPPVGSGYTFADFLQRLERSPVSHMSPLYHEHRPLFVNRPDMLSRAVLSISWERGLAILQAAYYTQPVAADTYRALLARMLRHNRHVSRTGAGQLVSWQAAMKVMNEAVLAHGTSLPTRVSVSTLRLLAPHRQWCTAIDVLKLNQANGQLTKPMLLDAAHACATSAAWPHAVKLLMHLHKQDSPLLFGAIQSMRPPGTTALTAATSAHALLPAVHDGRVPTPAQQHILSVLNDVVRSVPQEVAVRSPLCTSYLTHLLASTTLTPDLKVQRATAAMAQLPWTAALALLSDLSEPTLLTDAEWTRVHNTVLLPFSSAAGMKDSGNSTGAVRPRRRSLSAKKRLRMKRGASSAITLPSTAKPENGEKIVEGATPFSSTSITSSPSQMLPSVPATEAVHSHEDKVALATATLFSRMQLLHASPPTVAAMMAVMVDKLPTPAMATAFLQSCAAHLAQPVPTSSSAVEGLDTPLQGSSTTTGSVAATRHPVVLNALLRNCARHENGWATAAPALLERSAALAATPPELLSSLIRQLRQAKQVALAVRLLHEHIIPSDSLLTPASWEDMLECALAHNRAIHLRRRNRESASSRDGSATTKTTPRLSGVHWVSALSWVKSRQAAPSEDRIHKTGTGPSQGATPRRPVEVVALERPLSHKMLSLLINICVLGGSPQGALHALGYARRVNKTELPHTLQIRALLYCMQYDRPCEAEAVVEQCARCEGDAAALPLRHLLRLIGESKANADEGGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RU71</accession>
    <name>A0A088RU71_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_271940</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700280.1">
        <property type="nucleotide sequence ID" value="XM_010701978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RU71"/>
    <dbReference type="GeneID" id="22576372"/>
    <dbReference type="KEGG" id="lpan:LPMP_271940"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270027700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_271940"/>
    <dbReference type="eggNOG" id="KOG0663">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273318at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001063">
        <property type="entry name" value="Protein kinase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000875">
        <property type="entry name" value="Protein kinase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF107">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 11A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="274"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="33"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="154"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="298"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="378"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="798"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="899"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="380"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="444"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="464"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="819"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="929"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN99573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="959" mass="101870" checksum="468D4377540BE21E" modified="2014-11-26" version="1">MQVNSLLERMRKVRQEKAAAAAAATATAPPVVTNTTTTVPTANTTSRDAPTLNAADADATGGGGVAVSSSLSTGVAVPAPPPVFASPSLARLEYRDNATDPLCVPFTCDMVVSVLNTLLNDYQRHSTPGVTAVAPGGVNGSVAPTAKGVVASTEATGGAAHDVHASSKMSGESSGAGRRNSGTESQLVVEKAVARMREVLAAQGSPQMAPKATGDSKSSATAIETVTAAGPSISSLYSSSASLLADAAYNAACAVARVDVSGAVRPICRDVNYYTRVGRISQGVYGVVFRAVTTADYERQHRQQSRHRVTQQSSASSSAAPPPTHVQVYALKHIKKMWLEDSQVGLPPYLMREIDLLLRLQHPNIMGALELVLLDPTPVPRRLTSPPKSRSTSLSSSLSPSSSSESESPSTEQPADEATESDRPLRRPRSTAEDTTAPNPTKKAKSDSAGEPPLQRDEGRSVPQTQTTGAKGTAQDAVTTRPLAAVGAASKAKDVFLVMNYCPYDLGSYMRRYTTMAELRGSGDCKLPHTSTQVPFFHITPRNAHPQAAASYVARAKSIVYQLLRAVAFLHDSRILHRDLKMSNVLLAENGYVKVCDFGLGRLYREGQALTPTVVTLMYRAPELHFGVVDYSHKMDVWSVGCIFAELFLRRPLFHASTDSQHLLALCEVLGIPTEESFPGLYHLPQTKAMMQSLPRWNRTSRLASLFQRGAILPTVAHGSVPVAAEGALLPASGVDLLASVLQWNPRRRPSATEALQHRFFTEEPLPCAPAELMRPMPWLDAAAAAVHVMPSSALVCEDRRNQPGNPVSQGALPPATRMASNSAEGPSSASVPPAVQHVMDVPSGATVAVAAIQLASDTTGGASSLASASPDMFPGSNGNTVLSNTVGGGYQEAIGVRDYSGSDGDLAPEEEEEQRLKLHTRRSTRDQIEDEVDDSDSDAGTERLEQQVRFLANQDRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUR6</accession>
    <name>A0A088RUR6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_281150</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700455.1">
        <property type="nucleotide sequence ID" value="XM_010702153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUR6"/>
    <dbReference type="GeneID" id="22576560"/>
    <dbReference type="KEGG" id="lpan:LPMP_281150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280017500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_281150"/>
    <dbReference type="eggNOG" id="ENOG502RX5P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="434648at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052032">
        <property type="entry name" value="ATP-dep_AA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43585:SF2">
        <property type="entry name" value="ATP-GRASP ENZYME FSQD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43585">
        <property type="entry name" value="FUMIPYRROLE BIOSYNTHESIS PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13535">
        <property type="entry name" value="ATP-grasp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="7">
        <location>
            <begin position="247"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="443"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="718"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN99748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="787" mass="86970" checksum="2643A81BFD2B926B" modified="2014-11-26" version="1">MLFEKQQLAQALQLRYHCSEACATSTVNSYYPDEEKCRATISGKMTAPFVLIVGMVPKQHEYIESLSRDLATAFQNFPYLNGTAKPQDEEQQDGYINAVASGKSGKNGTTSPLAPIDWAEVRARLFSHEKAPLWYMYTELVFSGDTHDLRIYENAYQNLIVKEGFSHVLGCYASGDGMVPALDYVNARLCGEPVQSLARRMNFGEDIVEALDSVEAEVPTCVYTRVNVFGNNPATSCSSRQDKGHAQQVLKEAGLPYIRYCVTTRVDEAVAKVKDGTLLLPVVVKPNSGAGSEFVALCYTVEDIRVAFSMVEGVRTSQGTDAAQLVVEEYIEGPEYVVNTVSYQGVHVVTDVWESWKYPEPVVTTGLTRSAEEALRAAGIERQKQHKTSILYDRQTLIPNLADLPASHSARRIVEYTLKCLDALGLENGCGHSELRLDTRKMTREWRQQDRQRLRRKSPLGAANDESPSEGQPLLIELNSRMQGDIPRSNEVIGYDQYSLLVYISEAVNVFGAATAVSTAWPFRVDSSSRPPRVGEIPWPPVPRLYRARHSAGSPMTTTVLFLATKEECILNGVALQSLTELRTFQRFTRTIFKPNQPGFVTPLRRTIDLFSSPTSCVMQGSTADVEADCATIRSMESATLSSSTRAALFKLASSIHETERLRESIRTLDERLGAVTVAYRDAAALAGLSAGRTTEDGKVNDKYKSKGNGDHSCQSELVALQCRLSALQSELTCAKNNVSVYERRVQHQRTDFANALASQQPAPLYISYQDFSIMKATGVGNKLAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUT5</accession>
    <name>A0A088RUT5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_282950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700634.1">
        <property type="nucleotide sequence ID" value="XM_010702332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUT5"/>
    <dbReference type="GeneID" id="22576740"/>
    <dbReference type="KEGG" id="lpan:LPMP_282950"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280036300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_282950"/>
    <dbReference type="eggNOG" id="ENOG502RHMU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276262at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="73"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="498" mass="55565" checksum="1E1920A3BEEEFB39" modified="2014-11-26" version="1">MSDVPDAAAAKPRLRIEFPPVKDKEDFAKKQRAAVDQGEIRDDMENDIPPVIRSVLELSHLTMSGHSQWLRAAPGYQGGLFHKGKPFCFASGYRDTNRPLDVEDKGNHMKLKDPLVYGTLSLPVTAAYICELHGKGIFNLEKPLIQYLPELQDKLSEDVTARSVLSFTHGIDDAQLLQDAGAQWRRSYFSPSLCAATRARVYEPVNRFLAGGTVPATPLTGQQQRANLVQYVRTSPRITRNFTRSLHRAHISHTSVALLLAAVETQLKGRSFESDIRTVFFEPAQSHGTGYGAPTLWKDPNELFYQPTGQALQHESFKRPVTVGDPRNCGPAVWNGSLNLYAPVEDYGKLLLLSLDTIMDARELLGKPTNAGRRPYYDFGVLYVPAKDQLQLTKSVLYGTDALPSAASFCYSCEHDLGCFGIASCGTRGARFFVNNLSGIIQHLFVKHALAKGLDPEKPANLDDPAREGEETEETLKRAMKRQKFTSYFTKYEAHRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RV74</accession>
    <name>A0A088RV74_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Malate dehydrogenase</fullName>
            <ecNumber evidence="2 9">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CMDH</name>
        <name evidence="12" type="ORF">LPMP_283010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 2 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="2 9"/>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700640.1">
        <property type="nucleotide sequence ID" value="XM_010702338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RV74"/>
    <dbReference type="GeneID" id="22576746"/>
    <dbReference type="KEGG" id="lpan:LPMP_283010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280037000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_283010"/>
    <dbReference type="eggNOG" id="KOG1496">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4069699at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000010">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000002">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010945">
        <property type="entry name" value="Malate_DH_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01759">
        <property type="entry name" value="MalateDH-SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003916">
        <property type="entry name" value="PRK05442.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23382">
        <property type="entry name" value="MALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0520">NAD</keyword>
    <keyword evidence="3 8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="10">
        <location>
            <begin position="4"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="156"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="128"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN99933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="323" mass="34515" checksum="BABEBEC71B294CAC" modified="2014-11-26" version="1">MAAVKVAVTSAAGQIGYALVPLIARGILLGPSTHVELRLLDIEPALQALAGVEAELDDCAFPLLDKVIVTADPRVAFYEVTIAIMCGALPRKAGMGRKDLLEINARIFKEHGEAIAAVAASDCRVVVVGNPANTNALILLKSAQGKLNPRHVTAMTRLDHNRALSMLARKAGVPVSQVRNVIIWGNHSSTQVPDVDSAMIGTTPARDAIRDTPFDDDFVKGVRGRGTEIIHLRGLSSAMSAAKAAVDHVHDWMLGTPDGVYVSMGVYSNGNPYSVPDDLIFSFPCTCRGGEWFIVAGKLKGDPPQQRLAATIAELEEEKQIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RV87</accession>
    <name>A0A088RV87_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_291220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700730.1">
        <property type="nucleotide sequence ID" value="XM_010702428.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22576886"/>
    <dbReference type="KEGG" id="lpan:LPMP_291220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290016400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_291220"/>
    <dbReference type="eggNOG" id="ENOG502SF6X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267579at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="790"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="920"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1164"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1505"/>
            <end position="1524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1783"/>
            <end position="1812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1830"/>
            <end position="1853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2042"/>
            <end position="2089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2133"/>
            <end position="2162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2293"/>
            <end position="2327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2380"/>
            <end position="2422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="920"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="937"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1164"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1174"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="2135"/>
            <end position="2144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2293"/>
            <end position="2309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2316"/>
            <end position="2327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2386"/>
            <end position="2402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2403"/>
            <end position="2419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2470" mass="255461" checksum="62058FD0A7F7114A" modified="2014-11-26" version="1">MEYVLGVLYATKRYEPFHTSGVHPGASSLQHTQALLLHSGTFAMNSLAGVPVMPDAAGTESDNDNDDTAATWEDLPTPTAGNNRRSQVMFVFPTAKDAPVVKEAKAIKTTSPFRHGGSVEGEPLSPPLPLRALTSGVDRAPTMTLPSYLSGSRRRSLSLAAGGMQLLPSAAAAGDQTLSFPREGAALSPLVLGLSTPLNASDAVQNATGGGGAGVAAVGRPAVRPQRLEHIVPTKVIAGKYVLLYLPSPHRPGEASAAALWGSAGSAAAISPGGAAGGGGSAGPSGARAHQTSALVQSPQMDLSKPRLGASTSSSSYFMASVSPHAMSTSGGRANFSTPLNKSVESSSSTSTATVGGHHLSNHHISPGGAGSGSGAAARQAVVCAAAAAASTQQKLLLFYCLLLHYLAHQSPAQERTIGMSFLESHTELDTAAVGPVPVAVLELQYTTEGPVRSNAGGILGTSTLGGSGNVSAAADGHGGTVSVSPGSTAGGGGGAGGSASPPPSGNRTFAYSPAPASLSTHSVSEGARGSLMPPSASFGGSGYLSITPSVMASPRSSSAAHLFPNTGDPFVTQPEACADEDSATAATALRELLRGSLDNSDAVAAQRLSSVLRHLLDCQPDVWFNPDNISFDSELTQNPYYGGWYSVESNDGYRRVMQICNIQSWPAVVLVDPAGNVVTVEALKYMEDELARYVDEVDASIAKASVAHAAVSTAFPIEAAASLDVSAGDASTFAAVRTSVSVSSTSPHTSEVSQQASALRTFPQDEASINGLGVAAKSLLSPQLRVSRVTESQAASPSPTTTLFPDGTTVTDHSNTNPLEVPVKLAVDDGDKATSGPVGMPEGRSMSLSGSICRYESSFSVHDPQIPTAEPTPVKAVATTARYVEESSAFSAPSITTPATASISAVTVSPLLPNTSMSSNGFSAGTRQSIMSPGRGEVRDNQDDERGMGTEERALGIAATSRAAFRDESSNTRQRSGGICEKSTSLMAKPLAPPLSMPALQRSESTATPPAAFSLAKVCMTKDHTSFPSWDPKTYRGDVAGVLAVSDMDSEMVLLTGLGKMQTSRTHTSEGAAPSAAGEEEAKNWAPTMQVPLAPAVPLANAVTSGVVAHVKTAEGFIAATPGTPPTPPSPSPAPLPGFSSAFPWNRVLAEPLMAYQPPSLMTTSVGTATSVDSRRVKESAPQRDKTDSSPPLPSLRLLSHRATATASLGERRCGDGEDFREGLSGFDRTTGLSSAGAAGARHLAVPPRTPAAAAMAPLSMVHRQVGRSSRPASMSVSGVPEAAVACGPESGAMSHNSLFLQSGEVRGAAALQLELTTLADSSALTWSGLRLPIDPLHRLAFCTVTVSEVRERARQSSNNTVLSSSELGKTNEQPLVAPLTQGAVCQSLQAASNESLVFPSLSLANSIDNTNARRLAASHGLPSQPQLPLPTTQVPPQPSLLDTASQQIIEKLLEKWPREAAVKFSLCTHLLIVFGASWHPGMAKFVRAVRHLCSTINEPAYASPGAPDFRKRRGGDGDDAGGLRGGLSGLNIRGLNSQLSTEDDAVAPFASWKGFSNSSIDWTSGGVGDFAGGFGEASSRFEMRSFTSFTRADADGSNVSEEGERMRSACTLNEAAVVVDKSTAPDTTPRRRVQVIYISADESLQAVCSAMADMPGDWLCVSPYVAQSEPERQLQEHASDMARHIFHVKSFPRMVVVEMPYGQQQQQQQQQPANAECTGAVHTGDISAGGRGDVEGELGDAVGTLMTLYDIGAISQPASEQRHGGLWTVVQLHGEMHLYTDPEGKEFPWPSESARTRRTKQEDMPGLSRWKQQACASRISGFRQKQQRALPHTGLSLHPSPMLGSSSPDGLEDAMPLHSHTERLTVSDTPTKVTAIEADVLVSTADTVSLHPPVARLFPPIKPFLVADGELPSLLERGGYFVVLGAFGSVDRQLHQQCFNALDEVRQWLYAEVEARKQSAWSELTQLQAVASYGPYTTPFSVDGDRVTSSPAAFHPNTGGAVGMDEYTLPTRYSSGITAAAPLSIAPGGGDPDSAAALHGLGHGTFSNRSDSTPMAFEDGWPESRGGTSPKLAASSPPAPGRLSLQLDAPTGVHGIHVGGTPSLASAAATHKPIAAARPLPTVYFYDSILSHPPAPDSPPPATAARNTSGVPGGGGQDANKEVGLEAKAAPLSHTSPAPTGTPAKALPRRCGNDAENAVATAAFSPSPAPTPCVADNTSALRRHHARDLALLQEYIIAPILEVDERQLPVREGELYLACVRWPQRTSAVLRRCLTSEARPTAAALAVPSGSTAGLPAGSTSSSAAGSSFGGGLASPSSGSNSALRSLTASQSLGQTQPLPEVILRRSSTPTDASPSPSSPMTVPVLGSVSAAAITVSSDGSSHLLPPTTAPAALPSSSSAVTNSVGASASGTNTGLNSPPLGATLSNHTMLMEEECKEGSPYPDATPLASAEAIKSFLYDNILRLMEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVK1</accession>
    <name>A0A088RVK1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methylated-DNA--protein-cysteine methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">6-O-methylguanine-DNA methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">O-6-methylguanine-DNA-alkyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LPMP_261770</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = S-methyl-L-cysteinyl-[protein] + a 2'-deoxyguanosine in DNA</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MGMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="4"/>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699996.1">
        <property type="nucleotide sequence ID" value="XM_010701694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVK1"/>
    <dbReference type="GeneID" id="22576080"/>
    <dbReference type="KEGG" id="lpan:LPMP_261770"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260022200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_261770"/>
    <dbReference type="eggNOG" id="KOG4062">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1907495at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000900">
        <property type="entry name" value="6-O-methylguanine_DNA_methyltransferase_-_DNA_binding_domain_containing_protein_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46460">
        <property type="entry name" value="METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46460:SF1">
        <property type="entry name" value="METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding" evidence="13">
        <location>
            <begin position="173"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIN99289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="284" mass="30476" checksum="AFAD07933DB6F722" modified="2014-11-26" version="1">MTGQARLARRASKSVTAIKKASKKALSLPKSAFALPPQLKQAASAPLQSTNHMQLWLRTVHTPLGPFSLYVDADGAVRCCHWQRSMPGDAAALQTEAQEVCATMQSRWYKNATVTVAGVWADSADRVSGVPGESAVALLRDYFNPPTAKAGRPEELERLLMQVPIVYPPTTTFMAQAWATLRDTVPSGATISYKGLGVRVNKALHLPASAAVAPRAIGVAMGANPISVIVPCHRVLSSTNSLCGYGLGLRFKVWLLRHEQADVAADKLRVGEEENSVSTVASRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RW79</accession>
    <name>A0A088RW79_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ethanolamine kinase</fullName>
            <ecNumber evidence="3">2.7.1.82</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_271440</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.82" evidence="3"/>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700231.1">
        <property type="nucleotide sequence ID" value="XM_010701929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RW79"/>
    <dbReference type="GeneID" id="22576322"/>
    <dbReference type="KEGG" id="lpan:LPMP_271440"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270021400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_271440"/>
    <dbReference type="eggNOG" id="KOG4720">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10267235at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000893">
        <property type="entry name" value="Choline kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF66">
        <property type="entry name" value="ETHANOLAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="106"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN99524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="642" mass="71471" checksum="11E500EE5D44E14E" modified="2014-11-26" version="1">MAQITNMSITDNPHLRPIEIMEVVLTHCAPVLWRHDKARLENAPEWAAKLHALLNSKVKGVDDSSCRPLELSASQRPVMPQKSQDGFLTASVDVTACQASAKVIQPPQATPIPPPPLSQQGPQIPPPPPKHATAGAALPHTIPVVQCSSVSVDVTHHATCSNANTFSRSSTCSSTSRQHYPEVGAGNNRVCNSHPGPPPSVAPGASFSPCHNTKEYFEECGLPLTSATTHHGKVTVVSENDLLLSERSNTPELPSVPLQVKRLSGGITNELFHVYDEDHPSTSVVVRVFGKETDRVISRESELFYQSLFIPTYICGSNFLVYDFLDGYYTLPYQEMAAEATPIARAIAVFQVRATRAALRDHAPPLLRDSQNKDYWKDVNDQLLAEEGSTTSSRSTHRGESRFDRESNYLIGSLTKWADLVLSKEIVDKVHEDRRGSFLATARSLQSACAWIVSMLKRQETFLPEGVCHNDLLSANVMIHKVRKDVRVIDFDYTKRNFLLYDVANHFNEYSGLDCDYDTYFPSDAHMSAFIAEYRRAMRDALEASWAENSILTASTDGASREHEIFPNARELFWSDSEEAEVEVVARWTQLAKLLTLASHLSWSVWSLLQEAVSALDVDFLNYAQARYNRYLAVRAECSENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWE8</accession>
    <name>A0A088RWE8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GRAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_302650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701288.1">
        <property type="nucleotide sequence ID" value="XM_010702986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWE8"/>
    <dbReference type="GeneID" id="22577318"/>
    <dbReference type="KEGG" id="lpan:LPMP_302650"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300031200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_302650"/>
    <dbReference type="eggNOG" id="ENOG502RI94">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2162691at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140268">
        <property type="term" value="C:endoplasmic reticulum-plasma membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120015">
        <property type="term" value="F:sterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051482">
        <property type="entry name" value="Cholesterol_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319:SF4">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRAM" evidence="2">
        <location>
            <begin position="603"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="709" mass="76785" checksum="F5C9760056563939" modified="2014-11-26" version="1">MSTKSRAPVEIQKSFVQQVQNISAHTRGISDELALMSQSLRDSIEKNPGPTADLLAAASQLSSSTVRTCMNLCSCLHDLGSMGEAAETVLAAQPELEVALLLNFFGIFATQMSVFFKEMDAWWDRSCQCFSRSKAAFFRELPASSTLSAADIEREVSAMTSASTTGTWRYKENEALDDVVGRKLSQQHDEDGKLVSGGTALKKARKKASTAAEAETSTVAMSPRSQENFDASQNSHSSRGSTEDTMIALAAAAESGAQTAAPRQPKKKNSLPVVPVGDAPAGLMPEELSSLALSEPLYLLLTSTLEEALGAAVMAARPNVFSNLSSFTYNEPVATYYVRLVRPGSLAYFVYCNYIRGSVETQDDFLCDVLETDCAEVDPFVSPAGEVIVDDPSDLSSLPACAWGCGSSEDNERRLYTMYALVTQPSRVGPTAIIQDSLNMGAAREEVLHMVALVDGAPDFARVTCMVQSEGRPVEVPNQKQAAIITFSRSGFVQAGFVEVPDSEVKAAVSHTRLEKQSAADAEMSLFPREERGATTTFQPPVQLASLDQPTSSAGISFGGVARGAVQGGYEVLKAPFTVGRAVGGALLDVTGVTDTVRNNIEGLFRRAFPDLVGETVVDSFNCAWMERSIVKQGYLFITRYWVCFQSTVAAAHFSIEYDEIKDIVKCKSVKMFANAIEIKTHLNDTIFLTNFLQRDQAYDALMSQWLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWZ7</accession>
    <name>A0A088RWZ7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Haloacid dehalogenase-like hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_281460</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the HAD-like hydrolase superfamily. Cof family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700486.1">
        <property type="nucleotide sequence ID" value="XM_010702184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWZ7"/>
    <dbReference type="GeneID" id="22576591"/>
    <dbReference type="KEGG" id="lpan:LPMP_281460"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280020600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_281460"/>
    <dbReference type="eggNOG" id="ENOG502QUN8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27226at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07516">
        <property type="entry name" value="HAD_Pase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47267">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47267:SF5">
        <property type="entry name" value="DEHALOGENASE-LIKE HYDROLASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01140">
        <property type="entry name" value="C2.B:_Phosphomannomutase_and_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01228">
        <property type="entry name" value="COF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN99779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="281" mass="31415" checksum="EBA51CAF692F96E9" modified="2014-11-26" version="1">MTIKAIVTDLDGTLLNQQHCISDYTVKVLKRLKEKGICFIVATGRPYTEVFYRIRKCQLEPDYIITSNGARIHDGAFNLVREHNIRPEFVESLTRIRTIKNSATGAELPKKSITNIYREAEWLTDKSLPELSAAFHDDFHCTDLREGLYELQAAELHGVHEVWFIGERDELVQLDSALREQHSGHLSCTFSLPYILNCAPAGVNKGNSMREVAEVLGLTLDEVACFGDGMNDESMLQITATSFITANGQQELKEAVPHAQIIGTNADDGVAKKLEEMFLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RX91</accession>
    <name>A0A088RX91_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein kinase-like protein, putative</fullName>
            <ecNumber evidence="8">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_311720</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="8"/>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701563.1">
        <property type="nucleotide sequence ID" value="XM_010703261.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22577598"/>
    <dbReference type="KEGG" id="lpan:LPMP_311720"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000029900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310023800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_311720"/>
    <dbReference type="eggNOG" id="KOG0194">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="258103at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF47">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="990"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="524"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="622"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="906"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="481"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="638"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO00763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1311" mass="143791" checksum="21ABD3C97307EA46" modified="2014-11-26" version="1">MMKSLLLRIDVSWSVTYLLLLLCVAVPVLVVTQVYVTRMLLSSWHAVHNARVYYITERISISTASVRDIANGFMALNIPGRYKGRDSRLLQRLCSSLDHYDKMARFRALSLVSLTDENVTSCVHGIPIMDSIHTLTGYFARDHIINGSYLIDNETYDFVQPLQMVEEWPESARNISALMKTTYSGKPIFELLPAYLNGTMDSIDPRHHWIFPSATPHLLCYVLPLGYIVRSHANISSVHYTDFTQVQLDGSRMLMDYNFVEAPGFVMAIFIHQSLADDDPLVLSNSWGQPSVSNDSVYSIFGTAPVTYLKVSSISDPLMRAALKYVDLAALQLQGYRRTVDFEYSGAAAVVTAHSYTTGQGLVVPIVLASSHAAITAPYLRLRRILNAIVAVVILLLTVAFFGIARRLISQPLRRMTAFILTSLRAGRRAVFYTNRYTVLQLTEVHALIQAHKAAMKQLREIYAFVPDELRVGDSTRRINSSVSNTASSTDIPTSRKATKLGSRSLVTHLSTAVFLNIRSPAPRAGSQPVAPITALPPPPSAEHANKTSRPPQSLVTAVENAAQAANTANSGPFPTPAALTAFLTAVQELCRTHHGTLHRVCPDACVLHFHSAVRAHLPRGQGAASPAAAPTMRHGVPAAQPAPQPQALAPPEETWRHAAQDARRAAAFVLDLVSWVDAQSGSGASARGGGASPMPDVHALLDTSLFTCGQYCPAGSEQTLQVALGRDVQRALGRVPQRIGVRVAVTEETATLLRAEVRRRSRGCGTVDHGVRLIPVDVLRTGRAGLDSEVVVLYEALPGRVVGDAAWQRYARCCCDGFAHMLRGDYAGALNAYRGVAEIEDLEPGLLPPSMRREAAASAATGGAVSEQVGRLVRECEHRVRWRITEPLCRTSTRPLNLSQVLSKRPSEDVVEGGHSESVHETAREVERGVTEGRQRLFIGRAARDSREFSNYPEIHDRSVVYLQERQMTLRCVLPSAPRWIRDHMGLYWHLSRRKGEGEGIPVWQGMQMALGSAGFIASVSFFTFRDVHPVVAKTIRDAPPGPMSDTLRSATPVCGPSPTQEAFMKAVLVKYQYLRHPNIISLIGYSHSLEGGVVLIWEFSPGGTLRELLNRYGRLPTITTIRFGLQVLSALSFLHEHNVAHGNLNLDTVMVDSDGSCRLVGLYMHERIPFVLPGTHYMSPAMATGKLPTPPCDLFCYALLALEALTGEPCWRWTTNEDGQPFGTIPDLLVLMQNGGQAFCDAVVEGRVVANAEAFDTPMFAEKYSELARSTLRCCVSHTPSKRPTAVEVRNIVKILLSEGGLACEEDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXR9</accession>
    <name>A0A088RXR9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mut7-C RNAse domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_320760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO00963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701763.1">
        <property type="nucleotide sequence ID" value="XM_010703461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXR9"/>
    <dbReference type="GeneID" id="22577817"/>
    <dbReference type="KEGG" id="lpan:LPMP_320760"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320012600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_320760"/>
    <dbReference type="eggNOG" id="ENOG502S0BM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269563at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002782">
        <property type="entry name" value="Mut7-C_RNAse_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39081">
        <property type="entry name" value="MUT7-C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39081:SF1">
        <property type="entry name" value="MUT7-C RNASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01927">
        <property type="entry name" value="Mut7-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mut7-C RNAse" evidence="1">
        <location>
            <begin position="18"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="298" mass="34184" checksum="1C33366659800524" modified="2014-11-26" version="1">MPCEVPCSSSTHNEGKEPRFIMDFSMNKVAKYFRLLGYDTLCSRDVPQADLIPTACAEGRTLVTCSRPLARSAHAHNHRVRAMRHGTAKTMVGTARHVVAYDSDGESIYSEGNEEADVELQCLFTQQWRSSEFKRAMIELIQQAGLTYDLNRVFRRCVSCNELLVSVKKEEMRDRVVARIYEIYDEFTECPACRKVFWGFDGRNTINYKSFRSLNLLRSLCISAGAPVEEERTRLTRLRCFRSFPRIAKVLIFSYLEDLVMENMIGMFPALQDLAEEVREHRPNRGACPQDAAQQAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXV1</accession>
    <name>A0A088RXV1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">T-complex protein 1 subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">CCT-epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_321070</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO00993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701793.1">
        <property type="nucleotide sequence ID" value="XM_010703491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXV1"/>
    <dbReference type="GeneID" id="22577848"/>
    <dbReference type="KEGG" id="lpan:LPMP_321070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320016000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_321070"/>
    <dbReference type="eggNOG" id="KOG0357">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03339">
        <property type="entry name" value="TCP1_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000003">
        <property type="entry name" value="T-complex protein 1 subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012718">
        <property type="entry name" value="Chap_CCT_epsi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02343">
        <property type="entry name" value="chap_CCT_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0346">Stress response</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIO00993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="538" mass="59309" checksum="BD935F6459C7A1D9" modified="2014-11-26" version="1">MSLAFDEYGRPFLLVKEQQQKERVSGVEAQRTNILAALGVANVLKSSLGPRGMDKILTTPDNEVVVTNDGATILDLMDIDNEIGQLMVELSKSQDSEIGDGTTGVVCLAGALLEQATALLDKGIHSSRISEGYEKACEIACMRLEKVAETISLEKREFLLQTARSTLNSKVVNRERDRLAQICVDAVLAVADIERRDVNMDLIKVEGKVGGRLEDTCLVDGIVLDKDFSHPQMPKELTNPKMAILTCAFEPPKPKTKHTLQIKSAEHMRELHEQEQEYFRSEVQRCKDAGADLVICQWGFDDEANYLLYCNQLPAVRWVGGVELEMIAIATGGRIVPRFEDLTAEKLGTCGRVREVGFGTTRDRMIFVENCPNSKAVTVFIRGGNKMMIEEAKRALHDAICMVRNLIRDNRIVYGGGSAELAASSAVLAHADAVSTVDQYAIRAFADALESIPINLALNSGLDPIRALSDARKAQMEGKNPYAGIDCMDRGTIDMKQQQVFETLSGKCSQLRLATQVVKMILKIDDVIVTKPNEEQPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RY26</accession>
    <name>A0A088RY26_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_320260</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
            <location evidence="1 8">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the dynein light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO00914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701714.1">
        <property type="nucleotide sequence ID" value="XM_010703412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RY26"/>
    <dbReference type="GeneID" id="22577767"/>
    <dbReference type="KEGG" id="lpan:LPMP_320260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320007400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_320260"/>
    <dbReference type="eggNOG" id="KOG3430">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10033309at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21452">
        <property type="entry name" value="DLC-like_DYNLL1_DYNLL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000001">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF35">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 8" id="KW-0243">Dynein</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4 8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIO00914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="90" mass="10473" checksum="10357D334C4D1BEB" modified="2014-11-26" version="1">MYNDHKATVKNADMPEDMQADAIEVTLQAMEKFNIEKDIAAYIKKEFDKKYQPTWHCIVGRNFGSFVTHDTHCFLYFYLGQVAVLLFKCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RY54</accession>
    <name>A0A088RY54_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heat shock protein-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_322040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701888.1">
        <property type="nucleotide sequence ID" value="XM_010703586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RY54"/>
    <dbReference type="GeneID" id="22577945"/>
    <dbReference type="KEGG" id="lpan:LPMP_322040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320026000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_322040"/>
    <dbReference type="eggNOG" id="KOG0714">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000037">
        <property type="entry name" value="DnaJ heat shock protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000106">
        <property type="entry name" value="Putative heat shock protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000074">
        <property type="entry name" value="Putative heat shock protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051339">
        <property type="entry name" value="DnaJ_subfamily_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078:SF519">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="3"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="323" mass="35353" checksum="85BCE901DE367FA9" modified="2014-11-26" version="1">MIDYYEFLGLNRQSGDDDVAKAYRRYALAYNPQCHSNNADQETVQRNFTMAAQAYTVLSDPKTRAIYDIYGEEGVRHGGTGQQGVPGGINLDLIDPNAVFTRFFGVDNPFQVIGRIDGVKSNQHDFFSAVTGMPPNPPKCPSIEVLLPVTLEDVFYGATRRATWSASHAGMPALDAAATVTEESYEVRVEKGAKTGDHFTVEGRGNTCLGCARGDVVIVVNVMQHTRFRREGDDLVTKATISLRDALCGTTVTVHTMEGRELSILIDEIVDPTYRTRIAGEGLPNHGGVDAPRGDLVIEFTTKFPSFLTAEQKTEIGRILDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RY70</accession>
    <name>A0A088RY70_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Trypsin-like cysteine/serine peptidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_292780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700882.1">
        <property type="nucleotide sequence ID" value="XM_010702580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RY70"/>
    <dbReference type="GeneID" id="22577041"/>
    <dbReference type="KEGG" id="lpan:LPMP_292780"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290030900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_292780"/>
    <dbReference type="eggNOG" id="ENOG502S0AB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="238486at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO00225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="204" mass="21796" checksum="66ACC8538A8AB40A" modified="2014-11-26" version="1">MKPHGLAAVPSIVQPSPFLTRAICALYWKDTFLGSCVAIAPSIVMTAGHHYNAVRDDVGDFSVLTRPGHWAAVNYASKDSTYDVVVFWLCEEVTTHTALRGYLPSVGAQVATVWLSPRPPHDAIVSPGVVIESEADKCVARGTVSTTGSSGAPVVDVFGEHIVGLHLTSNTRDGSRVSGFIPSRKLVSLFAEMWVEHARVASPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RY81</accession>
    <name>A0A088RY81_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_300040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701040.1">
        <property type="nucleotide sequence ID" value="XM_010702738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RY81"/>
    <dbReference type="GeneID" id="22577058"/>
    <dbReference type="KEGG" id="lpan:LPMP_300040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300005400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_300040"/>
    <dbReference type="eggNOG" id="ENOG502QVY5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="274897at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO00240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="239" mass="28717" checksum="D263487F34CF4104" modified="2014-11-26" version="1">MRRRLQRRILSPRTSMRFFDSDDRFGKELGFGHKMRDIPVLTGNPRPVAREESWRCAYKLSDRMEFVIRDILTKNKWSPLEVDRELAQIFERKEVGSRSSLNTWSTVEEFQRTPWYRRYKPTDDTAAKYISYEAMKLLESALIPPSLRVDPYAHLRKRHMEDNWMNDKFSEDSAKYITRAGLAQHTKGMPQYGQMSRRKYMEFERKFRNMQGSNMHVNEIYSAWLSSLDDKNHEKRQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZN4</accession>
    <name>A0A088RZN4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_331290</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702221.1">
        <property type="nucleotide sequence ID" value="XM_010703919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZN4"/>
    <dbReference type="GeneID" id="22578282"/>
    <dbReference type="KEGG" id="lpan:LPMP_331290"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330018000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_331290"/>
    <dbReference type="eggNOG" id="KOG0281">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5580488at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044715">
        <property type="entry name" value="WDR86-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44489">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44489:SF11">
        <property type="entry name" value="WD REPEAT DOMAIN 86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="160"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="471"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="398"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="484"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO01421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="634" mass="68346" checksum="5ED5661C92078E76" modified="2014-11-26" version="1">MSVVPRLRTAGLSVNTREDAAVYAETKSFHAEGAVVTMAASYNSTMWLAMQDGRVEVRDVHTGQVVHVFAVAGVRQRRSKVWCMLSVYNSIHQEAQLWMGLSSGAIEVYTENYQLRWQLSKHLSGVYCLAQYRGDVAYAGSSDFTITQWRVADGRLLRVLTGHSNYVRCLYAEGNALVSGSDDNTVRVWDTSSGTSLQQYKHLHRESGGVSALCRVGTAMWSGDHSGVIAVWRLKDGEALLMCHQVQGRVTSLRKVGARVYAGSAEGRICVFNASDCTVVSRLDDHLGSNISAIACAVEVNRYFVWSGSADNTIQCWHHDEHQPMTAEREGALDMQWYYTTQLPYLQANEALLEQQRELMELVVLSSGSDDAVRSFLANLGEGHETAAARYWLLNGKVKQTQKRCDAMEEEIRAIDVAVERKAQTLEVLRRQLARLTEALASSRLQPPLPGGAPVPASMATELPAARASLSPPLVTIPPPSDTSALPSSPPSGIAAPPRPTTLASALPSVLPPPPLQVMVPAASLPLPSMAPVPERSSSPPRIVTGTQVTLSRSYEPVLSSLPPPPFTAGSRPTMEALLRMDGSGTAVPPPPAAVVPLPPVAAAPLPPSTGGVEPLGELPAKAATLPLTRRMSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZQ4</accession>
    <name>A0A088RZQ4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_331490</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702241.1">
        <property type="nucleotide sequence ID" value="XM_010703939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZQ4"/>
    <dbReference type="GeneID" id="22578302"/>
    <dbReference type="KEGG" id="lpan:LPMP_331490"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330021000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_331490"/>
    <dbReference type="eggNOG" id="KOG0288">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6262491at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045160">
        <property type="entry name" value="ATG16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19878">
        <property type="entry name" value="AUTOPHAGY PROTEIN 16-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19878:SF8">
        <property type="entry name" value="AUTOPHAGY-RELATED 16, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="291"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="324"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="356"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="576"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="229"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="54"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO01441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="589" mass="64927" checksum="07BF21867FE3FF34" modified="2014-11-26" version="1">MPIDLPVTVPSPTPAPQWLQDIENQLLIRNAVELKPSQLIFDSYTTLHASVLHLQAVEDERQQLRMEQSRLTERVRELERAAANTSVQTSRERELEAKKDALQDQLQLYTQRESDYYKGLAEMTALKEKKEKLELRSSKLEAELEQRTAELQLLHKEYTSLRDEYSRVRLTVSEADRYLRDVKTANEKIAQLQYRIVALESEVNMLRRRLQAALQGDIAAAVDENASANANEDGEGTAMTPSPICRNSSLHTDPHTAISSNSLGAEPSRASMIIPEAHSGSTLHGLCVLDDGKHFLTSGTDKHIRLWNRQSAQAEKYFSSNSIALALDSSSHYLLAGCADHVVRFWDLNSLRALEMTGHTEKVVAACLSSSAQHAFTASSDSTIKLWDIRRRESLRTLLCQSTCNDVTVVGDTVFSAHYNGKITVWDRRTATRSGEVVAHQRVATCVRVSANGMLCVSMGKDNIISVRDARVFTKVLFSTAPEQLTVMMNWARLAIAPTGHLCAVGSGRSSDLLLIRLDGRGQGDAEATDSISSPASVKVLKAFVPGSPSYSNQDSGSIKGPIFGTAWGANEGGPLVSISDDHSVQVWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZV1</accession>
    <name>A0A088RZV1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosome assembly protein rrb1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_332000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702291.1">
        <property type="nucleotide sequence ID" value="XM_010703989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZV1"/>
    <dbReference type="GeneID" id="22578353"/>
    <dbReference type="KEGG" id="lpan:LPMP_332000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330027100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_332000"/>
    <dbReference type="eggNOG" id="KOG0302">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2161379at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051972">
        <property type="entry name" value="Glutamate-rich_WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903:SF1">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="5">
        <location>
            <begin position="148"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="478"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="39"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="222"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="49"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO01491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="584" mass="65209" checksum="A67FF1E84A814DFB" modified="2014-11-26" version="1">MKRGAKRTSRDGEDAPGARIRTKDAKEMLKEEEALRQRELEEAKRQVELEDDDGSWEDDEGDVEDFEDDDKEEIIEASDENDDEYAEFQKESSAHITKGLKSISFKEAGQADSDDDDETGGAAAVSVWRGDIDGATVGEAEGCESMKLEFSNKAYDAFFQLRTEYPCLSFDVVKDNKENHTKYPLSTVLVCGTQADEQARNELLVLYVTNMCRTKYDVASDNDSEEDYIGEEDDSEEDEDDAVDEDVNDGEPVVHHRTIKHYGTANRVRCCPQNNPASGSQLVAVWSDAGHVQVFDIGSEVRALTDFSNWSKEQAQVWKQQSDGGQGKKAQPLKFCTPSTSHKTEGYGLDWSSVQTNVFASGDCAGSLFVWQPTDDGRWKSVASSIAPGAMSIEEIQWSPTQTDVLITTRAGGAVEVWDTRDMRACKISFQADSSDINVADWNRARQASHLLVTGAESGAVSVWDLRRIATPEPIQRIALHKKAITSVEFAPHNESVLSVLSDDGCCTLWDLSLERDVNEEQEAVGELFSGRLKEYPDQLMFHHQGLVHPKEAHWHMQVPGLVVTTDYEGLHLFRPINWKSLMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S031</accession>
    <name>A0A088S031_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">U3 small nucleolar RNA-associated protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_320170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO00905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701705.1">
        <property type="nucleotide sequence ID" value="XM_010703403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S031"/>
    <dbReference type="GeneID" id="22577758"/>
    <dbReference type="KEGG" id="lpan:LPMP_320170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320006500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_320170"/>
    <dbReference type="eggNOG" id="KOG2172">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277439at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006709">
        <property type="entry name" value="SSU_processome_Utp14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150:SF12">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04615">
        <property type="entry name" value="Utp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="77"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="164"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="626"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="720"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="592"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="626"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="644"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="735"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="756"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO00905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="993" mass="110485" checksum="D5BBF579E977B244" modified="2014-11-26" version="1">MVRRSEAAKGDKKGRRKGNRLARGRIDDGERQQSGKLMLNNPLIPPELDEDIDDDLAFNSEDERLYGDFFSEQASTKLKLSKKKSSARPSRDSALHDDDDDAFLEDGLAVVGESERSRATKRKNSRDAAVEADYGLDNYHEDGLHSDDDEDYIDLSDMLDMSMKAEKKKKQASAKKATRVTETGSKVAKKHRARQLADEPESVFGLAAASASGGAASYTGAMQCIMRQREPSTDGAVEVVKERIKRSHQSKHSLITVDADDLAKDRLTRKEVRAIVDEGMERYKPVLKELDSAKHIQFPMRLPHSTPVASSVGGIVAAADAQFRSDRTVRPAHSNSSAYRLGSKMDALLSKAGLSRRQVSDGADSSNCIGSYVPFNDGDVDVAQRHGVENGEAPTTGYVAKLKAMLAYENSRRKRLNRIKSKTYRRILRKEKEREKERRQKAFELLHPELARQRLAKRLFKTRVEERVTQKHKNTSAWVRHAKRFAQFDGETKDAIDDQHATHQRLMQKMEQDAGEENYERYVAVDNESGASSDDERAVDALIEKVGASGGASLSRQDVESILWSAVDAVEDGEDAAAEWKVDPISKARAELREMKFMKDAREREAKDYENELEALRRAIEVHQREELTGGEAKAEEAGDSGVARRPSSSSALPSAVGGRIVFKKGKKSGAVEEVRLRRQDGICIEANGDDAEPSSHNSEDADLDAIVAVSSAEGGGKISSVVASDPIGHLKAHTPQTEKTNKSAPSAQRTPEFAGARKDAQLERGLLKKKATSTRVTILPRRRARPDDTTATEKVTVAAGTLEDSTSVPEEELRLNQEYLISRAFAHDDVDEDFVKEKESQVETIMRPEDTNQSLPGWGEWGGEDPELNKRHQEAVLHQMTQRQIEKSFLLKSRADAALEHVIINHDGVELVPNRMTLHMVPRPFSNPQEFVRSMRQPMGPEWTSALSFKEGVQPRVEVRQGQSLLPLDLSLRKPLTKTKRRKTEAGSTRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0W6</accession>
    <name>A0A088S0W6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TAX-1 flagellar protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_344260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702848.1">
        <property type="nucleotide sequence ID" value="XM_010704546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0W6"/>
    <dbReference type="GeneID" id="22578931"/>
    <dbReference type="KEGG" id="lpan:LPMP_344260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340050100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_344260"/>
    <dbReference type="eggNOG" id="ENOG502QSY3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053248">
        <property type="entry name" value="Zinc_finger_MYND_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46533">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46533:SF1">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="407" mass="45129" checksum="712F1133D672BD35" modified="2014-11-26" version="1">MSYSKVMTGSTAVTGSTKCGTKRPGNSLGTAATYDKSQYDITNVTWGTLESRFDELIALMDTPTTGVNALKVTAANRQRIGSAIAALLDRAQDECRQLLLDGDAGAAEKAGVLVLRLRERFYKANHVELIPGYLHLARTMQFLKRYGDAEDMLSLAQYIMLKHTDEVTVTMKADLHQAFGLLYAADSKLEAAVQQLSRAIYYLSLQHGSRHVLTSFSYFDLGNVMAAKASMENAMALYDAVKEIWYAHLVTALTDVVARRKDMQAQLKYTENIPAQELRQACYATAHAFGSENLADASKMLHGISRIQQKRFHNVHPSPVRAEFILGLFLLWTDNESEAQRHLVAARAGSQHFYGPRHPVVQEIEGWCSKFELAYETTEDNLAKSEDIPIVEAGSKMHSDSAEASHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S196</accession>
    <name>A0A088S196_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycerol-3-phosphate acyltransferase, putative</fullName>
            <ecNumber evidence="1">2.3.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">GAT</name>
        <name evidence="1" type="ORF">LPMP_030070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.15" evidence="1"/>
    <dbReference type="EMBL" id="CP009372">
        <property type="protein sequence ID" value="AIN95241.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700949.1">
        <property type="nucleotide sequence ID" value="XM_010702647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S196"/>
    <dbReference type="GeneID" id="22571873"/>
    <dbReference type="KEGG" id="lpan:LPMP_030070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_030005600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_030070"/>
    <dbReference type="eggNOG" id="ENOG502QQ2N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2427554at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016287">
        <property type="term" value="F:glycerone-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07992">
        <property type="entry name" value="LPLAT_AAK14816-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052744">
        <property type="entry name" value="GPAT/DAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605:SF0">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN95241.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="717" mass="80130" checksum="419124F09907223F" modified="2026-01-28" version="2">MAVPADRSVKFSLEEESLAHAVENEASPSVAMMPAATAASPSMPEEFTDSTETHPTTSLPAAASVSPTVEETPAAACSSTSTAAAAVSRVAPKSALKSKDRIGASLRRSKFVFCEECHQSIPIEEWPDHRDRLRKVNLVEQVSRFHHTLVRLMGEFLMWVLRSVYFREVTVVGRENIPRAGAVVFYGNHQNQFIDALMMHSHCGRPVRFLMAEKSFHQPVIGTLGRMFNSVPVVRPQDVPLVAGDGKLVRTEGKLIIGSGTHFSKLSKGDVLIWGVPGNAKCRAQVSRITSDEEVEVTVPIPAEHEVHAPTSFKYSARIDHSEMYAQVYDTLQKNHCIGIFPEGGSHDHTSLLPLKAGVALFSLGAVERHISVKIVPVGLTYLYGHKFRSRAYIEFGEAFSPPDDLVKLFDTDKRKATGLFLEQLNAALHAVTINVPDYRTLSFLHSFRQLYQPPNCTLSGHDYLRLIRRLGNVIEEQRESAEFAEFREKVENYLDFCKALMIRDSQVATLKQLLHADSEALQIALLLRRVFALYLMAVILVPFFVVGLPIGGIIKYFALKRTKRALSESSVKIVGADVTGSFKVMFAFAVVPAAFLLVSFIVFLYSDTRTALVILFSLPMAMYVSLLILQEAIMELRATLPLLMSLASQHMQFKKLYERREDLAKQARLIVHKYDPQLEEEMKVYVGADDCNDDLSREPSLFSLRYNVRRRQATNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1I0</accession>
    <name>A0A088S1I0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_331230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702215.1">
        <property type="nucleotide sequence ID" value="XM_010703913.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22578276"/>
    <dbReference type="KEGG" id="lpan:LPMP_331230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330017400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_331230"/>
    <dbReference type="eggNOG" id="ENOG502S0H5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273467at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="747"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="753"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="766"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1381" mass="150605" checksum="55FD868666C24B3E" modified="2014-11-26" version="1">MSSEEYEEGDIASDQERRENDDVDEEDKDAVSDSAEERELPPSHPSDEEVEEEDYDALDDTPAPKPFPKTIRLRLPRQTSARAACEPTRVHVCLTRGIIGRPQEGGVHGKGSNSDEEDAALQVAPPAVAAGGSEADDGTEKEEENAVSSAAATLQGCCAENHRYETDYATPLAALRRRLILRHLHGDTKRQQRFLLSERAREKRNRLSAHGDAVEGEGEENDGGGEAEEEGGNADPLKEVVWPWTTLPKPPPYWLPALLSNDAHTFQRVLHIMYGWIIAPDPNPCDRLQLDATGQLCIGTPNTEEAKENSNNAEEADPAHHNTDFYLASGAFIGEGEEEVDEEACSNSANRDSVALAELTSKSLLGAFNDCELNEEEHHLGEETQSQQQDLGSLDGPGRSHVLSISTAPPPVAALPYFPFTEYELYIVYDATSEEWHLLDTHPLFVMEACRRRRAEQLARKEGQPRGEVADDASLGSDEETASETGSETGSEEEAKGGCHVPEYALDTIIPVSPVVLAALFSPAALRCCLLQPHRAEPQSEDDAGEVEDDDADGNAATAAAMHSVSSHAVLRTFDHAWLSVDTSAALPILATICRTRQRVLQQDALRIPYALGNLWIDVNPLYALPAFADVANGAGVDDVRQWRAQPGQHPEEDVGDDEVGPVSSPMKTAELCCSHRWGNALDSIVDPGHYGRLVLTSLLDAGLLPTRPVELAVFHRLSLLRLTLWWWMRLPAKLIQQWGFDAEDDGAGAGRSADDGDDTARMSDEGSEEEAVNDEELDEMAVEDVTELLLQRIEKISNRDARLRRFRLRTRHPTVVFAPLLQRVLLELQRRLDRMSAVDARGAPLAPSQYTLEESVARTYVAERLESGHPRQDPLVTVAFVGLADPATDETSAAPVAVRIAHVAAVRHQRLYQSDLVLLLLALTTTPIPRPSCAATILGDAEHCFTSTAGNTCKAEEVTVEEAQRDDIDAHTAFFAHLLELKSMRFLRRPQDRTRAGTTKLLLLCTIDFCRGATRQRVLGHLPPFELFGSTGYCPLPDLVQAWSFTCSINRNGNRAKKVATVQLFAYYLWNEIRWRQCKGQYSDAAVTRMREQLPELFELIDSNSSTYIAILAHLDAVAAAHSEAGGGGDGSLSASTAGRRAAPTGVSLHASRKQDCGVASLPAAVAQRQGPSLISTEVLQATQEEEREEADLAPTSVSLPLTLAYPNIYSAGVLESKALVNALWQSFAVAPHTYMTAETLHALLFGKNAHHSDDAGGIAVGAAGDTRRFNTAALSVMFENGVTTVQVCPLDCPEAPAIEEALKRADLPAVKVLLGLGAASLRDTCLNGSTTLELWAEKLFSPAEMDVLRFVAYKNKRAIRSDPRLQFGTRRFGSAVANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1K4</accession>
    <name>A0A088S1K4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein FAM184A/B N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_344720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702891.1">
        <property type="nucleotide sequence ID" value="XM_010704589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1K4"/>
    <dbReference type="GeneID" id="22578977"/>
    <dbReference type="KEGG" id="lpan:LPMP_344720"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340055000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_344720"/>
    <dbReference type="eggNOG" id="ENOG502RSJP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="75801at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18870">
        <property type="entry name" value="PROTEIN TAG-278-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18870:SF9">
        <property type="entry name" value="PROTEIN TAG-278-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="252"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="393"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="702"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="53"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="297"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="511"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="820"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="413"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="708"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO02091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1014" mass="113801" checksum="A3E3D3F7CCC2923F" modified="2014-11-26" version="1">MPCSVPTAFAVQDDGKHYKMCKKIAQLTKVIYTLNNCSEDNEQRTEWLHQMHRQEIAQLCQQYESELEKLQQQVCALQTDKRNIATSIERSLKEQLQAAQEAFMTRLAALSQRASEQELSYDSSLREEKQRMAAELAAETKRVRESKDVELQSLVREYNDKYKAMLAEQLDSRDALEAALKKEWGCKVEALQMELAAAQGDMKAQLQSKSKLLQETLQRCATLSSEKDLSAASLNEAQAQLQAFQGQLRRTEEELASERRRGANAEELENQRETRRVALESDRTALQRENTKVQESLAAEKALNARQAAAIQALENEKASLSTSREGLTQKLEDCKAALTACTAQRDAAEGELRDLHSCSAAHASSLSDATSQLGEAKQRIIFLEQAVAEGQRKHGEEATQAQQRLAAASHQAAEEARASQAKHEEELRNARESLQWNLSSEQQRLIETHTKVLEELKRQHETEMRRLQTEMAATQESFERASRMADATAALVSALTVRSEEQDALLRSRAEESAAERLQLEQQLQQLQLEVSAARNNGAKETAAQVAALERTQAEHAADCAAADAAHAKALCEAEEKSAAQLDRIRLDHAMLLKAIQEQHTIAMQRAKEDAAAQAASMSTSVETRLAAQQRDYEERLAVVHTAAATTEGQLHTRITELQAQLRQTVNEMSTLQASSSEGLRQRQADLAQLQSAMAKAQAEAAASLDSARRDAEEQRRNEVNSLEAMRQQQVGAERQRYEVAVAAHNEEIARMEAHAHERMAATETRLQETKASLEAMRIKGMEELEGRLNMMHQRQVRELTEAHDTERDQLQGSIDAMNVRLKELISSLASKAEALEELLAQRDRLLEDLTTAKRNGAAAVTAEQNRRAADLEELRLAHQKELNALSATHKEIVDDFSHQQAEERRAHQALVDQLRGTTEELQYKYNYRESRPEDVELINKLLLDIKKKECALNKAYEDMRLYKLELINREENYNKVFGRHPTVADYSGVAQAATKGQSALPSIGAIRKFSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1S3</accession>
    <name>A0A088S1S3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hemagglutinin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_352160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703153.1">
        <property type="nucleotide sequence ID" value="XM_010704851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1S3"/>
    <dbReference type="GeneID" id="22579245"/>
    <dbReference type="KEGG" id="lpan:LPMP_352160"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350027700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_352160"/>
    <dbReference type="eggNOG" id="ENOG502SK4F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267655at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="900"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1037"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1115"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1164"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="278"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="604"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="647"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="929"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1133"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1164"/>
            <end position="1173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1234" mass="130011" checksum="1964B2433B0DA0D9" modified="2014-11-26" version="1">MRITTATVTFPIGARGAEARKRSATTIGTVSRANVRRCPQPKLIFTPSGTVVRAVSGCEFSTSTTEGAIDTNGSIDSRSVAASVLPISVAPSSGNAHVPVRSISACAVLENQIVSNDTLEATRRSGAAGFPSSGKKDICSCKIPPATTNDPMTNILNTCFTAEAPLGVVEDSRAAAFEGVRANSPFVSSSSSSSDAISALQSKVAHAAERSSATHRSSNGVVAERPQLHPSLTQDNRSFLNPGYSSDPSEWNSNDGGDSSRHAGSDDSAGGSMHQHGPSAAPSRRTAPAAVPSVQGRGSCTSTPPPVVVTTSSGDENQTTLTFSLPTAAEEQATWQTYDTYSAQRPKRSHHRSHPSVIKHRSQSPAPAFPAVLSTSTSVGGREVLQLLPRLYQRAQVIVASTIKTATPTPALPQTKAVSSTMTTKRKDTLGEFPSTEYLLDAAQACFGARRFRALMAAVTTDGDTLVPTVVQNNGRGAPTISTASRSRLSSSSSQGLTIEEALSFLSRLKYALASDVPTQGNRKQAEPPAKLEVVTGGMEPDRPAKAASSQPPLGLHALRKTRSVSAPKSQAAPQVYRIPSAHVGRRSSRPPPTPTARMEVRRSTPASSPPSRAEVTGAAALTGPRKPTGRRRGPRRRAALPPPSPHLSSSDSGNPDATYRGDVIRMYVQRKAFAEIAEGQDRRRSPTVTLERLVKVLGWFELALNPSAVERVCGIPMQSAGEPRDISIDFNAFVKIMDSSLDCQHHSEGSRPSSEWASAPVTNNEDPQFNAIVLALPPEAPARAFPAVPLIPGLTAAGAASLSSGSGPAPCTQAAPYTSSVCDSGDSIRSLWSVAFGSSAAHRRSGSLSSVATTTASSAVSGASVPKSSVDTDDAYPLATHGSAVAALCRSIRQRLRQELRRSVSSGSDALPPPRESQGSGSKSGDGVAHKERDDSQRSPSTRTVLAASRWWRSPSPVSSSRVMMSSGDASAVGLVESDSLSSCHDSAGILSERLNGTKGNAQLACQTQREQAPSSPFVAHALPPSSHAYPLTTAPRDGRAQPGWGDESDIASHRSSAAQRWRGRGPRLNSPSLSIPATARRRSPSTPAARRCRQQQASIHLLTSLSPYCSPGQYLRRPASHHRSRSAAPSTLSRLQRSSPLHSRDSQSVLCTLLSARLDSSTSLRSHNVSAERTWKHPKRDRPATAYIRPAAAPTYGVCAPHLSHPPFSPTIRSAPLPFRRGLLQACWDGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1S7</accession>
    <name>A0A088S1S7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_350350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702974.1">
        <property type="nucleotide sequence ID" value="XM_010704672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1S7"/>
    <dbReference type="GeneID" id="22579064"/>
    <dbReference type="KEGG" id="lpan:LPMP_350350"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350008700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_350350"/>
    <dbReference type="eggNOG" id="ENOG502SB87">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="263296at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="503" mass="57058" checksum="468E123AF5425764" modified="2014-11-26" version="1">MQKRRTASATVLPQEVVVPHPPMSGTSAAAPRHRSYQANTTASSRPRHVSLNPPRHVPRCIFTAPTSVPWACTLRRSDDIFATISRSRQRHPRKAGGEDSLPLVKSSAVPSADEVKSLAVHCVPFGEKKLSMEVGEDSSHLNGLFDGGLSSSTLVAWPPKEPRRLSSQLGRSLRLKLDTAAIEEELGCSTNSPLENTVSLTDSQLVKFAAYDTLRLLFLPIWKLYRFHKQMVQTMAIVAKYAHPKIFQRRQRCSERAPDTILPKLRIPHTKLRWAAYFLETQAVCIQSAFRRHRARVQAVVELNYRKVRRDVEEAYWATVVAQREAELTQQQYPFNVLSNAVRQVIEASAESKMRTDTTTHRTNLLSLAANSTPATEAPSYELDVYNFFMIGRLPESLLRFETTSAVFAQLRRSAARAHLIDDFSSTRARRSAKEELRKLNDIPSTHKPVVCRRKCHAQLPHFLPESVYVAILNNTCYMTSLMRDDRMLRAHLHQQKHPLEPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1Y0</accession>
    <name>A0A088S1Y0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_350520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702991.1">
        <property type="nucleotide sequence ID" value="XM_010704689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1Y0"/>
    <dbReference type="GeneID" id="22579081"/>
    <dbReference type="KEGG" id="lpan:LPMP_350520"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350010500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_350520"/>
    <dbReference type="eggNOG" id="ENOG502RZ1B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="258081at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO02191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="442" mass="49507" checksum="CC292B3A686B423A" modified="2014-11-26" version="1">MENIMTEICLVANIIDRLLEANESLRADELLPLTKRLRAAASELSSINPQKQPNLVSSPLPRNVEGLNIMVSRGRQGPSKLQLPRTLAQFTAARRPTLRSHSLSDTCTKVGISKVPHEVSQSICCSLYNLLEGATRLLCASHGHIFVKRGDDMFSIANVSRTLVFPPPQVHHGCLCSADAEVLGSSIALNRYIDEVGRKRAVLVFPIYKIPIGNGPGEPVATIHVERRDHVSAPFSESDECTLYFASLFCGELMSRIPQFNFLESFYDPSTQHIIAPFEPCSSVLLPPIERGGVLTLGEPGKQSSEDPEYAKRAVSQLTRKIKAHSPEILVRRERLPVSNTKPFAPGMLMMPSLLEIQAYVENLQSCWKKNMLDNIDLLELDRETQQDLRLARNELTATRRNLAATADKLRLYELDTWDYKLEYDAMKSELSTYMDGLERLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S262</accession>
    <name>A0A088S262_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Surface antigen like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_051200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="AIN95561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703883.1">
        <property type="nucleotide sequence ID" value="XM_010705581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S262"/>
    <dbReference type="GeneID" id="22572198"/>
    <dbReference type="KEGG" id="lpan:LPMP_051200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_050016400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_051200"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051848">
        <property type="entry name" value="PGIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48059:SF30">
        <property type="entry name" value="OS06G0587000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48059">
        <property type="entry name" value="POLYGALACTURONASE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839198" evidence="3">
        <location>
            <begin position="27"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN95561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="284" mass="30198" checksum="9F8EC5156D13DCE3" modified="2014-11-26" version="1">MGFSLLSIIGVAVVTLLLVVAAPSCADSIIVNEATRAWLNMWVDAIPNLQIIWMNPNICSRSGIECVSATNSINIRLDAVTSAGFNFIGTLPEVSHSIDGSQLQITSVSVSGKTRFTGTIPASWARITRLTSLDFSRTRMSGRIPDSLGNLPNLVSINFANAYFCYGLPNWNASGLPMLTQATFANNNMRGPFASSWSTFPASMSLDITGNKLCGCMPKSWESKPNLVAAAKAMDPGTASGCFRSCNSASLSYCPAPPTANGAQMITMSMTMIIMVVAVISLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2E4</accession>
    <name>A0A088S2E4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_352920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703229.1">
        <property type="nucleotide sequence ID" value="XM_010704927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2E4"/>
    <dbReference type="GeneID" id="22579321"/>
    <dbReference type="KEGG" id="lpan:LPMP_352920"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350036600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_352920"/>
    <dbReference type="eggNOG" id="ENOG502SFZN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272458at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="4"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="92" mass="10185" checksum="C7E06A3BB51DE425" modified="2014-11-26" version="1">MSTVAELQAELEALRAKNAQEVEAAQATLAKLQQDLNYMQEDTESLEREEEELCKRFGKDRGTDTASSMNQHTDIIAQGLCGLVDCDDSKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2P1</accession>
    <name>A0A088S2P1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Succinate dehydrogenase assembly factor 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_070400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SDHAF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009376">
        <property type="protein sequence ID" value="AIN95726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704048.1">
        <property type="nucleotide sequence ID" value="XM_010705746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2P1"/>
    <dbReference type="GeneID" id="22572375"/>
    <dbReference type="KEGG" id="lpan:LPMP_070400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_070009100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_070400"/>
    <dbReference type="eggNOG" id="ENOG502S3R8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="274783at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012875">
        <property type="entry name" value="SDHF4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28524">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28524:SF3">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07896">
        <property type="entry name" value="DUF1674"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="107" mass="12024" checksum="13D1AA2EC6B3F4F1" modified="2014-11-26" version="1">MFRRCAPAFIGVEGDTFVSAIKDKQYLAHRLAILGKEDPSFKPQRMSDDDVRRFTTSLGSTESLFNKQAGAIPTNIVDEETGRVIGSTQLDPTRYGDWEVNGRCYDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S359</accession>
    <name>A0A088S359_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calphotin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_357060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703633.1">
        <property type="nucleotide sequence ID" value="XM_010705331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S359"/>
    <dbReference type="GeneID" id="22579734"/>
    <dbReference type="KEGG" id="lpan:LPMP_357060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350080300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_357060"/>
    <dbReference type="eggNOG" id="ENOG502S44J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="250537at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO02833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="429" mass="46113" checksum="21F79DD6CEBB6DA1" modified="2014-11-26" version="1">MSSVLTPVAPASPATSRKVTFVLPGEAKEVTAASPPAVPILVPSMPAVLPPTPAPLAAPSVPALPSLDFPQLHATEEELPKTMMSVNYASSEEKPVSPEEVPDYSKWVYPVLMEGSSACSPPLKFPLTDVIAPHVLTPAALLRWSEREVLATLPTMLPPDYIIFGGAKYSSTSLDLVHPPLAVATSAKRTLDFHNAMEAQRLQFLVDQLEVARHYLKIEARRVTKAQRTASTLTTAGYTAVPIDTVSDAIQKSGETEDVAMTNIWSAAYFGSPQQLTAMMEKCKLDGVLDSVGYVHYRRRLWGLKRVGDRFELGLGLRGTLLQFAAAAGKLDNVVILLTSGARDTATPRLKEILSAESMQIVEAILIPRTHAPRHNRAPTVGVMATSKATPPVMERTFISEHVVKIDEEGLSPLGRASDIAAAAMAAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3J4</accession>
    <name>A0A088S3J4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerophosphoryl diester phosphodiesterase, putative</fullName>
            <ecNumber evidence="2">3.1.4.46</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_356120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.4.46" evidence="2"/>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703541.1">
        <property type="nucleotide sequence ID" value="XM_010705239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3J4"/>
    <dbReference type="GeneID" id="22579640"/>
    <dbReference type="KEGG" id="lpan:LPMP_356120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350069600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_356120"/>
    <dbReference type="eggNOG" id="KOG2258">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1058301at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008889">
        <property type="term" value="F:glycerophosphodiester phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006580">
        <property type="term" value="P:ethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070291">
        <property type="term" value="P:N-acylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08566">
        <property type="entry name" value="GDPD_AtGDE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032160">
        <property type="entry name" value="DUF4996"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46320">
        <property type="entry name" value="GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46320:SF1">
        <property type="entry name" value="GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16387">
        <property type="entry name" value="DUF4996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="56"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="315" mass="35609" checksum="2BA9ED167FECA0C9" modified="2014-11-26" version="1">MLSASTVCQPLFQHTALAQKNQVNDKSLNQRFIRDFMNPRPHLRISLHSPDSNLPVCVACHRGDWRNYVENTLEAVESCIQMGADIVEVDVWRTSDGVLILMHDETLDRTTNGTGRVCDHTLAEVRALRLKDGLGNMTEFTVPTVEEVLLLAKDRVILNLDKADVYLDELYPLLVKTGMVEQTILKSEISFEDLCKRYSVDLLNSVIFMPIVSVTDTTTYESIDRVFATNHDLYEVNFENENTDMLHYIRKLAKSSGAALWINTIWPTTCGGYSDDHALRDKDANWGYVVDHIGAGIIQTDRPAMLLAYLQGRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3K7</accession>
    <name>A0A088S3K7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thymocyte nuclear protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_357070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703634.1">
        <property type="nucleotide sequence ID" value="XM_010705332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3K7"/>
    <dbReference type="GeneID" id="22579735"/>
    <dbReference type="KEGG" id="lpan:LPMP_357070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350080400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_357070"/>
    <dbReference type="eggNOG" id="KOG3383">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="41445at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd21133">
        <property type="entry name" value="EVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.590.10:FF:000003">
        <property type="entry name" value="Thymocyte nuclear protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052181">
        <property type="entry name" value="5hmC_binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002740">
        <property type="entry name" value="EVE_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047197">
        <property type="entry name" value="THYN1-like_EVE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14087">
        <property type="entry name" value="THYMOCYTE NUCLEAR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14087:SF7">
        <property type="entry name" value="THYMOCYTE NUCLEAR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01878">
        <property type="entry name" value="EVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EVE" evidence="5">
        <location>
            <begin position="13"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO02834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="164" mass="18973" checksum="FC6A06F647D83D02" modified="2014-11-26" version="1">MSRKRMRAEDIHYWLLKSEPHKFSIDDLAKQKTSTWDGVRNYAARNNMRAMAVGDKALFYHSNTKEPGVAGIAEVVRLAYDDFTALDKTSEYFDPKATKEKNPWQMVDVKFVEKWNAVVTLQAMKSRRELQKMALFTQSRLSVQPVGAAEYAYVLRMNEEQAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3R4</accession>
    <name>A0A088S3R4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nucleoporin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_357090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the non-repetitive/WGA-negative nucleoporin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703636.1">
        <property type="nucleotide sequence ID" value="XM_010705334.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22579737"/>
    <dbReference type="KEGG" id="lpan:LPMP_357090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350080600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_357090"/>
    <dbReference type="eggNOG" id="KOG1900">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="338970at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.450:FF:000006">
        <property type="entry name" value="Putative nuclear pore complex protein (NUP155)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.450">
        <property type="entry name" value="Nucleoporin, helical domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004870">
        <property type="entry name" value="Nucleoporin_Nup155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042533">
        <property type="entry name" value="Nucleoporin_Nup155_C_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="6">
        <location>
            <begin position="58"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="5">
        <location>
            <begin position="762"/>
            <end position="1213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO02836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1303" mass="143772" checksum="95DC6D72DFB11A0E" modified="2014-11-26" version="1">MQQQLSTARHGAKHMVEDTVSAVLSSAAVERHPNPHAIGFVRSNSYALSTRDSTYAVPDFFPVGGVAWPEPLLELWKSMRYSSLTGVFADLSRVWFTVDNRLVIWDYHGGREFCIYDEIPELISVVGAPLRPLSGVFQPHVTYIIPVGTTSMMFLLGLCIMGEGAQAEMKVVNLGYSCSTDTVITKAIGSGGHVFCAGADGNVYEVRYMRDNTPITPKIRMVSYGYWLSTAPVLGQVTSVVASVWQSWRGGMHGGLIDLVVDERDGILATLCERSRISLWRLIPSGGMRYILSLRHRPGRLPRSHTTSNGEPAPLVRLFVIETDAQGCRLMAIALNGDQFRYRYINIFDSVFSAELILQSHTPSYLSVNKEISVCYASASAFLAAFSDMNDDRASDEVLAATSPATVIAPHQNVRDIVATFSGSSSRIVRVDAIERMPTQGSQNLSDLCAQVCSPGPTYVVVHRHGLSLFAQARPVDTLYLILLISDADCREGLLSRFTSVYSAPDYAAMLLQIAVGALNATTKLPLPFTKDSAFLSSHDDGVPLNELGQQLLSGSSAEVLRRARELLRSLQLPVTQASNGMDAEVQNVVVLMSPFATGLVAFVARALCLLWNTAMSAITQSSATTTVRVLEKIIQYLDSLSISVLPEHQRTLNFQHEWQVDKVVVMVPRDRSLRAEDVKRLQAAMLYNCYELVHKAWQATTLLQRVLGIPLYSEDASVTFAQVMRDAGVAQRLGHYLSQVMLDSQYGISAGSGHRVVSFAQLQRQCPYFFGGISSETYQLQSDMLSLTRGESLQFYTEAQMHKWAAEVGAKAAAYWPSGALQSICEQLRSLKRENVAVELLLHAAAQLDPGNAALAVFLAEGPCQVGDKTRYASAYSAHQTKTQVLELVVSTLESAWLTHRSVVEDLLGGPRRSGTIWQVEPSDEYAHCFLFDWMCAPRDDRNTTKLLRETLVAARSPFLSNYLRRNAEVLAEEYAHYLASVQGDYRGAMQQCFVMALAPLPDTPVADRLQYRLRCLREALDCARKCQSDQTQQVEQQLRLMEAQQRLYRIATEFLSSGSATLDRRVKWEGDVVTERDVAVQHIEFLSSFVASASDLIEVGGMYPALGGAEVQLDALLCSNVTDAGVYATCISRAYENQKDKTETITKRLIDKYFHQISCFPLSHLVRLLEARAFLRAPTGSAHVVQLLMSLAVDPKVLFITYESILEGRDDTGVECVEFAEAGVTRGYLVYAYATVLVNLADLGRRGSVQQWIVTNAMAATRSMIRRAANIVTSPNEQLAVERAEELLRKANTLAASGVCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S495</accession>
    <name>A0A088S495_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_353080</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703245.1">
        <property type="nucleotide sequence ID" value="XM_010704943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S495"/>
    <dbReference type="GeneID" id="22579337"/>
    <dbReference type="KEGG" id="lpan:LPMP_353080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350038300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_353080"/>
    <dbReference type="eggNOG" id="KOG1651">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="446890at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000364">
        <property type="entry name" value="Glutathione peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF78">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 5 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO02445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="152" mass="16996" checksum="AA2B4631AA36F29D" modified="2014-11-26" version="1">MASIFTYSAVQGGKTVSLQRYSGYVTLIVNVASRCSFTSTNVEMLNGVQQAYGSRRFTILAFPCAQFANQEPLSNAEIAQWCENIGLLFPVFDRVNVKNPSAHPLFRMLRAQQGAPMWNYTKYLCDRSGVPRRKLEPGCSMDALRQSIESVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S4C2</accession>
    <name>A0A088S4C2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_353380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703275.1">
        <property type="nucleotide sequence ID" value="XM_010704973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S4C2"/>
    <dbReference type="GeneID" id="22579367"/>
    <dbReference type="KEGG" id="lpan:LPMP_353380"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350041700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_353380"/>
    <dbReference type="eggNOG" id="ENOG502RYHA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267746at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38019">
        <property type="entry name" value="KDA ANTIGEN P200, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38019:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="820" mass="92872" checksum="8A23AD7D502FBDEF" modified="2014-11-26" version="1">MSRPRESSQKPACYGCMTLPNIPRIAADERSRQKYLSEYEKYEPELRRHHLGAADTTSMLGLKDVPADFDRTVPSLLGPTEAELEYERACESRKAQAMRKGRRGVSAWATQAATTDVLTPAAGKSISPQPPLFVSADKEPQQRGTPSASRSSSAADTPTTTAAAPAALAAGEEAMQLTPVEAAGTRTRTAEATEAAPGHIPQPSSAGPRQKPAPPPTSMSQPRARTAPSLKPPPTATRLGQHNSSSSVTSAQAVRPKPGQRSQPVRGILPATVPTTPRRPCAPFAAHEASTAESTARLLRVLLDPPQQYASSLHLNLSFFDLGWLRNGKAVPHRLTTIASYFSDNGASPQLRINSPRSVLTLLENGVSPKDWDPRSDTAFAFTLGETPQDMAAVQAEVLEHRRAYVQEQRDALHRTLQDSYSLLCARAPFNELVGSYRRLCEADMFESAALEEEEMSLATAVLQWQEQQRRVFETSRARMMRQVQQAKELQERQDSAMQRKLQAEAEAEGERRRKAMEMQARHRIQQARLEAYHAERQRREEAYKQLLQARLNKAATCNAERMAARERQRQTMQQRREAQEAERSRRLVRNAAILEEQAAVQEQKRQEKEASLEKLRATREARLEEEHRVLVEKQQRAAYLREDAKQRAAEAEEAVRQAALQRQLQAEERQRAFQARRQEEAAQRAAALATHHERLNEIRSQALAKEELFKATVEEKHRQHEDHHRDTRARQLVNIMWRREADWEREEAKAYAVLQLQRIAEFNKLHTVVDLLEKRKAANTIVRQRELIYEESIRARDKLRAEQDALKQRITSLPQQMWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S4I9</accession>
    <name>A0A088S4I9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Regulator of chromosome condensation, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_354170</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703350.1">
        <property type="nucleotide sequence ID" value="XM_010705048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S4I9"/>
    <dbReference type="GeneID" id="22579445"/>
    <dbReference type="KEGG" id="lpan:LPMP_354170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350049800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_354170"/>
    <dbReference type="eggNOG" id="KOG1426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.30:FF:000062">
        <property type="entry name" value="Regulator of chromosome condensation (RCC1) repeat, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF441">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RCC1-like" evidence="4">
        <location>
            <begin position="94"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="105"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="159"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="218"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="284"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="600"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO02550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="688" mass="74851" checksum="D82CFCD3F1A6A998" modified="2014-11-26" version="1">MFFWGSYNFQEPQLSENPDRPPLRYPGYLPPSLAVLRRSTPAKPNATATSSLQSDVASVEETLRGITAMRMQVHYIACGVKHLVAAVSLVPVAEAALAGDGKTVIALYGMGNNEYGQLGHHVANYATALTHLHLEDLMEGTVVSVACGARHTIVCTSTGCVYVAGDNSFHQLGLPGQMVKPRPRGGTYAPSFTQLKNLAHVKAVYASGNASFALDRRGQVYSWGESRYGHLGHNDNGERLDMHTLKTVSIDVETPQLMRWFERHRVMIVKVAVGRSHVVCCSEDDVYTCGEPLFGKLGHGDIDPRLEPTRVEFPPRKQAERLLDIAAGDDHTLVLKENPLIGSVVYFFGKLSNGDGQLRPTIVQLPTTAVRSVMAGRGTFCAVITQGRELYVWGKHAYTKVYNGTNAAASRTQPSKVQLLEPYAIDGVVSGGTFVVAYAGAETVMRPVLDPTAAGDGKGAMKEGDDTTNEEAVAVTRAARSWDVVVPHDARVGRDGLGDPEELYEEGLRALLRQYLGPALGNAYVAQLPVAPPRSSAPVYQFDHIAVKDLSRGQKVRLWMTNIYALGTIVDELADQPPGASSCQARETSTSSAATAIVPHTPSQHGERSQAAASTQPGVTVEEDADKDSSASPKGKRVKVEWQRDDWSDEVVTLYSEDETLNEENANRWQPFWFEQNPEGEYVVPKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S914</accession>
    <name>A0A088S914_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ferredoxin NADP+ reductase-like protein</fullName>
            <ecNumber evidence="7">1.18.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_210450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.18.1.2" evidence="7"/>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698833.1">
        <property type="nucleotide sequence ID" value="XM_010700531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S914"/>
    <dbReference type="GeneID" id="22574867"/>
    <dbReference type="KEGG" id="lpan:LPMP_210450"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210009100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_210450"/>
    <dbReference type="eggNOG" id="KOG1800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="333024at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004324">
        <property type="term" value="F:ferredoxin-NADP+ reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055275">
        <property type="entry name" value="Ferredox_Rdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48467">
        <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48467:SF1">
        <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="35"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN98126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="693" mass="74235" checksum="F2913B12F64B7622" modified="2014-11-26" version="1">MFAPTLAITRALNTKVSWALPRTLALSAPVRWCSSKGGSSNGTEHRAGGSDTENASSASASAPNPSTVGTTAPKRRVQIAVVGSGPSGCFVASYLVKKHRELHVDIFERLPVPFGLCRYGVSPDHPEIRNVEKQMMELFQGGRVTWVGNVSIGKEIPLQALLAHYAAVVFATGADGSKKLGLPGEDLGGVISARSFVEYYNTLPFPYGSPHFCPFDLERTKRAVVIGNGNVAMDVVRVLGGSYRYFSTTDMNCMCIKELMKNQVEHISVVARRGVEHSAFATAEFRELTKYQKDRVKVEVDYFDLNAAVAAMPVGKVMRAHKRMMEFVHQHVLTSEETAAEAVQLATDAQGVPLPCAVAASTAPSPAEPSATATALECGMGRPQRENRGPCRLRFRFNLTPVAILPSRHHKNYVGGVLFKKTHAEAPSKAAADADGYCVVPCDLVMTSIGYRSDSIADVPFDHRTGVIDNEKGRVKGMPRVYCAGWAKNGAKGIILHSVVDAQETAATILADMEAGVIPTEPTAQPGEAEGAAAAVRSSSADAADAEPVVVLSFGSGNSTSHRQAAGAAATTMLGKYGLVDYFVTKKLQPVSIAGLQRILNVEHQRGVDLGKKAEKIGTVRDMLDVALGGDVGKKADERIRGITPVRSDAMLYLKELLDDDTDLAAFARQVARDVPHKLSQQHPLGRIAPNQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S9G1</accession>
    <name>A0A088S9G1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Calcineurin B subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CNB</name>
        <name evidence="5" type="ORF">LPMP_211940</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698978.1">
        <property type="nucleotide sequence ID" value="XM_010700676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S9G1"/>
    <dbReference type="GeneID" id="22575016"/>
    <dbReference type="KEGG" id="lpan:LPMP_211940"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210023400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_211940"/>
    <dbReference type="eggNOG" id="KOG0034">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000471">
        <property type="entry name" value="Calcineurin b subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45942">
        <property type="entry name" value="PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="23"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="60"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="92"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="133"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN98271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="175" mass="19746" checksum="BE40521DF48FF689" modified="2014-11-26" version="1">MNEIPLTAEELQDIRESTALTDAQVQRLYKSFTRLNKDKSGKITREEFNSIPALASNPLVDRVLAVMDTNGDSTVDFGDFVRALAVLSSATSKEDKLRFTFKMYDIDGDGRISNKDLFQMLSIMVGVNLSQMQLQQIVDKTFIEADADRDGYITFEEFQALAVNSDFGDRLNLHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S9G5</accession>
    <name>A0A088S9G5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_211990</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698983.1">
        <property type="nucleotide sequence ID" value="XM_010700681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S9G5"/>
    <dbReference type="GeneID" id="22575021"/>
    <dbReference type="KEGG" id="lpan:LPMP_211990"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_211990"/>
    <dbReference type="eggNOG" id="ENOG502SG4T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="243817at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="101"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN98276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="155" mass="17590" checksum="744355DBFA6F2E4A" modified="2014-11-26" version="1">MNPLHREKQLFQSDITDLILTMVETLAREQYLQHARMDARLNELEEKVMSSQLHVGLKMAHKNSTCSEDSDGESTNTTFSPDKVETPESNSSADGLAAPMCDYCFLFSHSCFPCPRCGREWYCSAACQRLRHRCHASRCGQPNLPQTCLHTRIAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SA16</accession>
    <name>A0A088SA16_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_230350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699193.1">
        <property type="nucleotide sequence ID" value="XM_010700891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SA16"/>
    <dbReference type="GeneID" id="22575239"/>
    <dbReference type="KEGG" id="lpan:LPMP_230350"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230008800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_230350"/>
    <dbReference type="eggNOG" id="ENOG502S7I1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273368at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="272" mass="29361" checksum="42838915043F7173" modified="2014-11-26" version="1">MSGVLRAKLPPPPSYGSSGTSHSDAILGHTVGALRLHRSPLNRGVRRTTECPCAVRLYHMTGHDIAARSEYCSFVLGAPSVGISQAAQPRIPPLPPGNQEAAAAWAGSSPSTVGIAAAEKPIAVQLAWADTTVWEVALTALRVVRSKVDVAYKADARHALRQANSNTTPMSAAQDRLRQRAEEDHSDSKEEEEAPYSTPLPRYQVELLTGTVSPEGRASVLPLCMVSCRQVVYGHSTLLPVRRADCVHYNTALYELPYNLGDPVFVTCTRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SDE2</accession>
    <name>A0A088SDE2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_281230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700463.1">
        <property type="nucleotide sequence ID" value="XM_010702161.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22576568"/>
    <dbReference type="KEGG" id="lpan:LPMP_281230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280018200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_281230"/>
    <dbReference type="eggNOG" id="ENOG502SSDQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="249624at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="641"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="843"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="906"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1102"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1216"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1346"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1469"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="909"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="986"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1026"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1057"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1116"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1174"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1476"/>
            <end position="1488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1488" mass="158684" checksum="1B8429E199629DCC" modified="2014-11-26" version="1">MFTFRPSPARHSQSWRESCKPEKYGATAAASTALAEAFPLMLREDNVRQPTWAMEMRRNSQFSGGGAVDDGHSVVSPKTTKSFSESRASSHAARHTENFKRATPEFEDWLAVGKVQQGELTTAQQTDLSWWFHDERLAAKTPFAAVVPCPARMSMEKAQQAVAAVIDAFAFPTFYVQTLPVGATLSDVAQAFVKRPAHLPEERRYRNAEKTGVYAYTAVPCRGGRDAMKLVMQSSALKDALREVPCLLLNDYRPLTPLCLRCLVVAGRCVAAEVACDEAYAPLFGLYPNNTGAAGTGDTNHASDAHMTAGRRCGASVAACHHRLTTLTGEDGEGTVQRTASDVVAYGLQSYVEEVLGQSLGNRAYTAVLSAEVKGFDPHVLRPRVSDPPFWPLMGREPLQLRRPPFEENSLQFFILSLEPADPGPFEAFGPEELHAISHYVLERAKAGAFLPPVVRFLDGHEVERAAARLPCSPTPLSVRRSPVAEASEKEGNGKSRHHSSVTLPKPANVASEISGASSRGTSATDISSSAGPQRTQSHRDGEAGPEPLNAPSHRPPPRMITSLSSTALVTESLMVATERVASIPRSVDSRRAAQRHFDSNNVQAPTSSFALQDGDSTHEDAYATATYQSYTSDALRSISGSSRVSCTGSGRLPPRVSSFDRSTSAAAAAPVTGTEAMPRLPARHEGYSVSAPSSRVDVLSNHVLTPSLACHRESSVVGAPRSEKTLVSPIRTTMVVGRTDGESTSAASSCSSHLPERCFSTAANSLSDRCQSNVARCGSDTQRATDLLSLRPSLPPRRQLSVIGAASATAAAAATSVHTSSISDNTSSENCVVASSAKSSRNPMVVSSHRSTTAKETIVAAAPGTEQTTTAEDPVLPSRLSAEDMPMVASRSLPSRMASFSAFSMTQSMNSSNPKSRSSAPPSTATKSSSSLSPAFLVGESCRRPRSRNSNTNNFPVASSRPEDISMVQPPVEPCPSPEKATSTEEVAAAERIASAAQESSPTLAPASWITQEGSPSGPRDQDSVEASTPGSRMAQSSSSVPEPLQYSADDCTGNVEHESNQHTDDRDDKGEKGQPSEEAFEVGERAFMCFSSILPSASLCRARGSVVRSRPRETSTMLPSSRHSVVRGAESDKYSSSMQNDKQEDDKRRTSYTSSRFQNKAAAEEADKASHRSSIPPSRSATSYHDLGVGLEVPEEELAVTEGTHWAEEARDTVEAEAATSCGGDNDSPSQHGAKKGAVSAVYEEEDGYEDVTPGDEAATAELQAVGSEEQPARSRHNLTAFNQCKAPSCFSSFEKSENTIVHDDGEEAGSAYHYHYTRHTDGCSEQQVMNSADLESRISTALSAASTQTTGRRQWVSRPASEANRRPPSNAPSWGPSTDIAGAQHESSDIESESTSSLMLPVPPCKVATTGTVEEKSARASAASNSSRCSVFATSSAAYSFATAQAPSTTDLWLSQSFTRFSVDSGHDGAPASVQSLQQHTSRMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SGR2</accession>
    <name>A0A088SGR2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LPMP_321160</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPL family. K-HECT subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701802.1">
        <property type="nucleotide sequence ID" value="XM_010703500.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22577857"/>
    <dbReference type="KEGG" id="lpan:LPMP_321160"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320016900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_321160"/>
    <dbReference type="eggNOG" id="KOG0168">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0170">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271273at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02249">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045322">
        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057948">
        <property type="entry name" value="TPR_TRIP12_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670:SF14">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25579">
        <property type="entry name" value="TPR_TRIP12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="12">
        <location>
            <begin position="456"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="13">
        <location>
            <begin position="1282"/>
            <end position="1622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="302"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="383"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="904"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="964"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="303"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="319"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="396"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="967"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="9">
        <location>
            <position position="1589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIO01002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1622" mass="178357" checksum="169F3B87ED6ED983" modified="2014-11-26" version="1">MDDFRFYMEGVGLLEGNTRRANAELIAAINSPDPMVQYSGLQVLCDQLTMSSFISPSTMATIPLILPAVLRCIASSHAREVFITAARALTYIIDAFPRTFETTPTRTTLVEVLLQHLRSIQDVELSEQCITCLELITRSQMGSRELLRSDGVEAVLGFADFFTLHKQRQIWTIVQRLVGEVDESSVQHITACLPTLRLGMTNGDAEIRQKAIATLAQAIEGVKMNRATVETVFGDAADRIASLLHERDVNDDALSSALFLLYAGVQWSAAIASSVIQSGLFNTLLSLLEPVPTPALVAEQQTASSSIGRARRGNGAAERIGERETGREDGHGAGSEAAVVRTLVLTSHQRTTVCRLLASLLIPYRTGAAEQLERLEMLTQRPLRTGAPALGNHVDMDDDDDEDEDYTTEEEDGGDEVPDLDDDSSGDATLSQLRQRLAHEQGLRIETKPAYARCRASGFICDGCGKNCLPGDWYRCNECPDKDYCTACVLQQYKQDHDGQHSYTDMEQVVGATARNRDKLELYRTSPQLLQRVLEAIPTVVGVCVASEVVAVRVSCLDFLVSAVDMASREQLIASGITNLPLGEVLNNNLRGADLLCNALAVALAGRLLITASDAYQVQFVREGVKLSLQLLKQRCRVRGRATLTREARAALTTSTAGWCTIIGTEASTLLQRFVGIEDEQEVESLRRVVQELRQDHFSTAVSLLRDLLSADITAFEFYSSGIVRELRSCLGRLQNIYAVMYLVAALSSSSTKKKGAGESSAADVPLTSAATAASWGGHSRCSLLAHFVHHLHTILTLLDDFAVPTYDFIGDVHHYFVVSFEPHHATVAVAGDMPSATSTSNARGSGGDSSLSPRECIKARIRPISSVSAMVQVLQQEVLRQESEEGNDGDREDDEAVTNILPDLHPRHSSASGSADVPAPANLSQPPSPPANSIWIRYGAHVLPLSMTMLQIMEHLVLPAAATSTDETRTSPHANTEQRPKPRHTVTASEEGGDEEQEAGHGAHNRLVGLDTSNAAGFSLQRPVVLHYSTTPYNPQQYSLYKVPNAFPASGNPQAPLQVRLPSQDCEPSAVRSVKQQLAGAFHYSRHVLSDSQRDVLGLLGILHAAVVNWVALLTYVQKQAAAASKHLHGIDVACILKTFAPAISITEFQHPKLNSKAAQQCSQMLLAGQQRGTWAVKLALDCTYLFNYSTRKFLFDVGFTSTDRCLIRMRKYRELFGLNEPRVSSEQMRSVYGQLKKEAKRVWREDILECAKTVLGAQDAQERNRVWSFHFYNENGWGDGPTREFYTLVSQQLRQRKLGLWRNGNEAAEDTEYDVTAVGLFPRPMPPGSAQEKQHLVPFFRLVGRFIGRALLDEHVPGLPLSPVFLRLLRGDVCGVYDVQDISEEVGRLLVAMTEAAGHGHTRLQLPGQKKVVEVQDLALDFTLPGDDSVELCPDGANTLVTAENMMAYCDAVTSFLLDRGVAAAVHALREGFHWYIPLVALHMLSVDELHQLLAGHETAVTREDFEKYSEANYGYTLNCKHVQWLFDILAAFTVEEQKLFFLFLTGSAHLPVGGLARLRPSFTIVRKTSEDAGIKEEDMLPSAMTCQNYLKLPQYNTKEEMEKKLRFAMAEGSGAFLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SGZ6</accession>
    <name>A0A088SGZ6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_321970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701882.1">
        <property type="nucleotide sequence ID" value="XM_010703580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SGZ6"/>
    <dbReference type="GeneID" id="22577938"/>
    <dbReference type="KEGG" id="lpan:LPMP_321970"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320025200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_321970"/>
    <dbReference type="eggNOG" id="ENOG502S8NE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1707486at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22928">
        <property type="entry name" value="HFD_POLE3_DPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="158" mass="16404" checksum="AB79288D5CBD40A6" modified="2014-11-26" version="1">MSAGAFHTMSRLSDKNSEMTVSLTHSGESVARKGSLGAVTAVDIDPMSDSGHARMPSSKSSGPGSSMKARSLAAGQVNRIVDGALPEGISVSRDARIALQKCATISFFYLACLGDSSRKATGSTRTTLNVQDIRGAMEAAGMAHLLPLMSMAAKRGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SHA6</accession>
    <name>A0A088SHA6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_322970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701982.1">
        <property type="nucleotide sequence ID" value="XM_010703680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SHA6"/>
    <dbReference type="GeneID" id="22578038"/>
    <dbReference type="KEGG" id="lpan:LPMP_322970"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320036100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_322970"/>
    <dbReference type="eggNOG" id="ENOG502S3D2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266480at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37028:SF4">
        <property type="entry name" value="ALMS MOTIF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37028">
        <property type="entry name" value="UNNAMED PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="704"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="800"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="987"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1049"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="994"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1009"/>
            <end position="1024"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1114" mass="120033" checksum="E22FEDDA44D0491F" modified="2014-11-26" version="1">MHAVSLRESDDHSCGDGEQFYTATVNVNPTSSSPHTLPRIENHESHDANTLIVTPAAATETSGMLTLEEILDGPASCPSSTSAAPTDSAMNRLLTTTQRDSRDKQKAPPAAGPAYAEKDATAASLTEHSKGANTPTELSAVANLAPLSSSSRAVQSGSSVVAAPAHSPAPSAGLASSGAPLSVLTTLPADLLVATAAESVTLKLYQETSSPHANHDATAALQAAEAGNVAGHSPIAKTLAAKGEGSSRPLVRATSCSAARAVRREVVGREHNSSEVTVSKRERKTGGVTTAYIAALLRGILGTSLPADRAVIHSRKTCAVSTAPPPIASLDLPVGLLVLYCAAEETCAALEGERASSTTSTAATSAYSLLYILEQISEARCRDHRQAALKQASELEQAKCEELYKAAEKKRALHAAHQAARAQAVEQEELGACTFHPAVSEAAQRMKVTGAKNFMQRCMDWKALMDRRLRQKYDQRAEAEAEQWTAAAAQIGILAPDGVVTEGSRRLLAEPSVQERLKSRPCLWEAKRPSENLWEAGVSVFVPAHAPTDTAASFPHLLGAPITSSIVEDQEAVLRDLRRPGTGEGVSCDPSLLQQLQGTPPPRASKSSGGTVKGFLRRVEQDARRREQTVAKLRARYHNPDTEHFEGGTGQPLFQPNAMPTAWKDGHRVSYDDLSKEEQESFRAELRRAGLDFVLSHYLRERQREKQQGVTDSLQEPSAMEQGDGDDTTEGGTVPRHSTSSQSHGHIMAMTHHARFMASLEAALERKKKNWERLRAQATAEETFHPQITKQSVRMALHKTGGTPIYGRPVEPRREASASGARLEKSPQQTSSSFPKDRALPEVAKIFLARNGKWMESRQRRLQHLAEMEEERRYAGCTFTPNCHFTDTREMTGPPIGMEAGLTGASSHTDSSLAPCMAGGEVKDHRGASQSHVRPQSLMASAADVRVMNELELLRSGAAYRDEDFVQAVCERSGLADARRAMANLSLHSAPRLSRSRKDARRASKPTHQSSVSLPQSPLSPILQRSERRSASPYLLPRRDTRASFSLFQGSVPRPAPAHLQTESTQTPMRRSVAGGATAVLSGARDSVSSFAPVEDPWAALDAQIDAILKLRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SHP0</accession>
    <name>A0A088SHP0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_330590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702152.1">
        <property type="nucleotide sequence ID" value="XM_010703850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SHP0"/>
    <dbReference type="GeneID" id="22578212"/>
    <dbReference type="KEGG" id="lpan:LPMP_330590"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330010500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_330590"/>
    <dbReference type="eggNOG" id="ENOG502S6DM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="256733at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="138" mass="15574" checksum="E06CF311C1A61D93" modified="2014-11-26" version="1">MGQSLNPLRTHDEVPDDIKAVIPPVEYPVAPAESRPHDRELCEDCREYFGWFCSSTNCDWCGRQLCTRCCPNRHLLGGHPGCKECTRKAFCIRREAMLEDHLKNARLPLQYPRDRSVEGASISTASGSTERGINALKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SIN7</accession>
    <name>A0A088SIN7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_340330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702462.1">
        <property type="nucleotide sequence ID" value="XM_010704160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SIN7"/>
    <dbReference type="GeneID" id="22578537"/>
    <dbReference type="KEGG" id="lpan:LPMP_340330"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340008400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_340330"/>
    <dbReference type="eggNOG" id="ENOG502QVDH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9994559at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144052">
        <property type="entry name" value="Thermophilic metalloprotease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="702" mass="75890" checksum="DDFBB324B8B5A345" modified="2014-11-26" version="1">MSATIKAACACASTLLFHSLRLHAFRGAFPHILIVVDRVPCVLQKVVTEGYLQMLRAYGQQGAAYLTENHDSLLATSTETLAETADDRGSLKGHGGDLFIPLEPGAETPSGSAGFTMHVPLPSFATDDPAPLSYSLMPFCSEDFLSRVRRLQQFFRHCGDGQLQHQGDQHEAAAAAGGATMTSPPAAPSSVWTAELFREEFDELCPLLEPLLSSKGDSVEVDVAEGKPLWQALFNGPPRELLGCVLVQENAFQNEMRRYRLRLNLFDLGVRVAEHCHLGIMSQRADRLAAEGRLKEALEDDQVYSYARSCAFRPEQAQCLAKAIADSIDLYSWCRAGGASCAAARVGQALPASITAALQSAELWSIFNSGALDGCTSATAADRTAMDVGVALQEPIEGPGIPLLIVCRDAAKVLTYGGGMEDCLTNTGYYEAAYVPERNDVARHRERFRTAYNEVSGGGGESEGVEENTAATPPMHGRLKKKEYLAMLKEKGQKPNKPQSDGAEEEDGAVSRSAPAGSCISNSIGGTFPIGEVITESFDLSQLSGTCDVFAYPDMFKQVTMSHPAPFTMTVERGVVTHISNGAPKEFLDLLSLVRQVEGKCYVRELGIGLNPYVGPAHVVSDVTTFERQWGIHLSLGQRHPLFVKQRERRNADGTVAAGVQVDGPILKRKAGKYHIDVFVDAAQLRMGNMFVVDFTKGIAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SJR0</accession>
    <name>A0A088SJR0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LisH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_344250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02047.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702847.1">
        <property type="nucleotide sequence ID" value="XM_010704545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SJR0"/>
    <dbReference type="GeneID" id="22578930"/>
    <dbReference type="KEGG" id="lpan:LPMP_344250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340050000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_344250"/>
    <dbReference type="eggNOG" id="ENOG502REM6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268066at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37541:SF1">
        <property type="entry name" value="LISH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37541">
        <property type="entry name" value="SRP40_C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO02047.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="579" mass="61310" checksum="C0F6AF589BAEE597" modified="2026-01-28" version="2">MSLRLPKNELEAHIYLYLKDCKYTNAAQALEEVNPKAVTYSRKISVSALTIASQAPAAAMDSDSDSDDDEPVRKPVAKKPSPKMAPKKPPVADSDSDDDEAVRKPVAKKPSPKMAPKKAPIADSDSDDNEAVRKPVAKKPSPKMAPKKAPVADSDSDDDEPVRKPVAKKPSPKMAPKKAPVADSDSDDDEAVRKPVAKKPSPKMAPKKAPIADSDSDDDIPVHKPIPAKRPVTNSSSDDDDEPVRKPVAKKPSPKMAPKKAPVADSDSDDDEAVRKPVAKKPSPKMAPKKAPIADSDSDDDEAVRKPVAKKPSPKMAPKKAPIADSDSDDDIPVHKPIPAKRPVTNSSSDDDDEPVRKPVAKKPSPKMAPKKAPIADSDSDDDEPVRKPVAETTANDSDYDEVQVQKRPKAQEDDEEDEPIRQINRTEGQSNHGNYGSRGGRGGFRGGDRGGFRGGDRGGFRGGDRGGFRGGDRGGFRGGDRGGFRGGDRGGFRGGDRGGFRGGDRGGFRGGDRGGFRGGDRGGFRGGDRGGFRGGDRGGFRGGDRGGFRGRGGAPQIGLSTPALNSMNQSVKLGSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SKZ8</accession>
    <name>A0A088SKZ8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_353450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703282.1">
        <property type="nucleotide sequence ID" value="XM_010704980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SKZ8"/>
    <dbReference type="GeneID" id="22579374"/>
    <dbReference type="KEGG" id="lpan:LPMP_353450"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350042500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_353450"/>
    <dbReference type="eggNOG" id="ENOG502S5YW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268840at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="CDD" id="cd23017">
        <property type="entry name" value="mt-LAF19-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO02482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="102" mass="11890" checksum="0C624FE76549DF0D" modified="2014-11-26" version="1">MGLKRLAKAAKVTSKHMLLLNRREPYKPVTRDRVMIENRRRLEVFEAKNAEGIVFVPDTALPPWQKSIATNLKQQATQMNFRGFRVRAADRQDEPGFPTHFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A514</accession>
    <name>A0AC62A514_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glutamate 5-kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2420010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="XUY36890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="264" mass="29346" checksum="8A49CDEAD9FF6698" modified="2026-01-28" version="1">MAEVLKLVKRIVVKVGSSILVENQEIASHRIEALCRFVAELQARYEVILVTSGAVAAGYTKKEMDKSFVPNKQALASMGQPLLMHMYYTEFQKHGILCAQMLLAAYDLDSRKRTINAHNTIEVLLSHKVIPIINENDATALHELVFGDNDRLSALVAHRFKADLLVILSDIDGYYTANPRTCTDAKIRKVVHEIDPSELVAEATPNNRFATGGIVTKLQAAQFLLERGGRMYLSSGLQLETVRDFLIGGHHELGTLFYPRVLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A578</accession>
    <name>A0AC62A578_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ama1 protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3020090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="XUY36959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="155" mass="17619" checksum="47267F696C3EE7A5" modified="2026-01-28" version="1">MSGKDGNILSYPAGVPTGHNAVTNRGWWHFSLCVCCKDCDSCCESWCCTPCQLSRQCNMLANNRKEIHWPYCLLMTFCDYTLFIFSVSCIFVSETRRMARERYGISGSTVEDCCYGYWCTPCSTQQVLLEMTLMNEFPGATCYEVTSHPAGRRMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5E1</accession>
    <name>A0AC62A5E1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histone H3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1620710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="XUY37082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="66" mass="7238" checksum="D87F239EB5F19D1A" modified="2026-01-28" version="1">MPCARCRACRRRGGPALPEQRDPGDPGGVRCVADGCHEPGQHPREACVTVRPKDVQLAVRLRGERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5G2</accession>
    <name>A0AC62A5G2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histone H3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1620240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="XUY37035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="66" mass="7238" checksum="D87F239EB5F19D1A" modified="2026-01-28" version="1">MPCARCRACRRRGGPALPEQRDPGDPGGVRCVADGCHEPGQHPREACVTVRPKDVQLAVRLRGERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5J8</accession>
    <name>A0AC62A5J8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">6-phosphogluconolactonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2420020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="XUY36891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="267" mass="28641" checksum="B42261F65831C3C6" modified="2026-01-28" version="1">MTSFAPTVKICENLSQMSFAAREVILAAIDARVDKSVPVVLALSGGSTPKRLYEELHEKDLALLQQHAVQFILGDERLLSEDDEQSNFSMATKALLRDVPSSDVISIDRRAALATSKDEKGGLDGAWAVAQDYEVKLLNCLPCKQINGTAKSVPVVDIVLLGFGSDGHTASIFPDSVAATDEEHVVSVSFPSPTMSPKVWRVTLSKTVIQYAKHVVVLAAGKDKNWVVRGVLSESPTDPLPVSRFLRDCRGSVTLLLDPGAGEGVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5L6</accession>
    <name>A0AC62A5L6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histone H3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1620690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="XUY37080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="66" mass="7238" checksum="D87F239EB5F19D1A" modified="2026-01-28" version="1">MPCARCRACRRRGGPALPEQRDPGDPGGVRCVADGCHEPGQHPREACVTVRPKDVQLAVRLRGERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5P0</accession>
    <name>A0AC62A5P0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Kinesin K39, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1420050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="XUY37003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2024" mass="224284" checksum="C9963F805CDAC402" modified="2026-01-28" version="1">MMGADVKTLGGEGSGVTPRICLEIFERKASVEAEGHSRWSVELGYVEVYNERVSDLLGKRKKGAKDGGEEVHVDVREHPSRGVFLEGQRVVEVGCLDDVVRLIELGNGVRHTAATKMNERSSRSHAIIMLLLREERTMTTTSGETIRTAGKNSRMNLVDLAGSERVAQSQVEGQQFKEATHINLSLTTLGRVIDVLADMAKKGARAQYTVAPFRDSKLTFILRDSLGGNSKTFMIATVSPSALNYEETLSTLRYASRARDIVNVAQVNEDPRARRIRELEEQMADMRKAMAGGDPAYVSELKEKLTLLESEAQKRAADLQALEREREHNQVQERLLRATEAEKSELEARAAALQKEMTATRRQADEMQTLNMRLKEEQESKERELLDEMAKKDAAVAEQHRLVVEKERILQQTVCALERERRSQQSLMDSLKAHQQRLMEALEENQQSDAQRRAFIAEKQQLQLEWNQQQLRQASHMERLLEQLKQAKDECDCQAHVHNLLRHETESRYHLLDQYSQWYAQLEKTKAQQQLALHERYEQLLQDTITTNEAQVTDTEAQVAKLQQQITNQKKTSQICEQKLKSHLAQVENLYHTLQGIHTRLEGEHAELGKAHAKLGKTNAALEQQLAEWKARATSVDAERGDLSERLARLEGEHAELGKAHAKLDKTNTALEQQLAEWKARATSVDAERGDLSERLARLEGEHAELGKAHAKLGKTNAAMGKTNTALEQQLVEWKARATSVDAERGDLSERLARLEGEHAELGKAHAKLDKTNTALEQQLAEWKARATSVDAERGDLSERLARLEGEHAELGKAHAKLGKTNAELGKTNTALEQQLAEWKARATSVDAERGDLSERLARLEGEHAELGKAHAKLDKTNTALEQQLAEWKARATSVDAERGDLSERLARLEGEHAELGKAHAKLGKTNAAMGKTNTALEQQLVEWKARATSVDAERGDLSERLARLEGEHAELGKTNTALEQQLAEWKARATSVDAERGDLSERLARLEGEHAELGKAHAKLGKTNAELGKTNTALEQQLVEWKARATSVDAERGDLSERLARLEGEHAELGKAHAKLDKTNTALEQQLAEWKARATSVDAERGDLSERLARLEGEHAELGKAHAKLGKTNAELGKTNTALEQQLVEWKARATSVDAERGDLSERLARLEGEHAELGKTNTALEQQLVEWKARATSVDAERGDLSERLARLEGEHAELGKAHAKLGKTNTELGKTNTALEQQLAEWKARATSVDAERGDLSERLARLEGEHAELGKAHAKLDKTNAELGKTNTALEQQLVEWKARATSVDAERGDLSERLARLEGEHAELGKAHAKLDKTNTALEQQLAEWKARATSVDAERGDLSERLARLEGEHAELGKAHAKLGKTNTELGKTNTALEQQLAEWKARATSVDAERGDLSERLARLEGEHAELGKAHAKLDKTNAELGKTNTALEQQLVEWKARATSVDAERGDLSERLARLEGEHAELGKAHAKLDKTNTALEQQLAEWKARATSVDAERGDLSERLARLEGEHAELGKAHAKLGKTNAELGKTNTALEQQLAEWKARATSVDAERGDLSERLARLEGEHAELGKTNTALEQQLVEWKGRATSVDAERGDLSERLARLEGEHAELGKAHAKLGKTNAELGKTNTALEQQLAEWKARATSVDAERGDLSERLARLEGEHAELGKAHAKLDKTNAELGKTNTALEQQLVEWKARATSVDAERGDLSERLARLEGEHAELGKAHAKLDKTNTALEQQLAEWKARATSVDAERGDLSERLARLEGEHAELGKTNTALEQQLVEWKARATSVDAERGDLSERLARLEGEHAELGKAHAKLDKTNTALEQQLAEWKARATSVDAERGDLSERLARLEGEHAELGKGYAKLTELHTDIEEEVQTGRRVKEELERTVEGLRERAVCAENDVQQLTRDVLIARTCAKEWEGLCCTLSLRLEVHREAHASHSVLAGDGELLSARGLSATLTMTSKAAPLTAVKYPTTARLAELLRSGNFKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6G1</accession>
    <name>A0AC62A6G1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">20s proteasome beta 7 subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2021240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0647">Proteasome</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="220" mass="24563" checksum="7DAFC8CE2B85EB20" modified="2026-01-28" version="1">MASGGSIVAIKYNGGVLMAADTLLSYGSLAKWPNIPRIKLLGGHSAVCATGSYADFQMMAKRVEDNIERQKMYHNVDEMHPNEVFSYLHRSIYQKRCDFEPCLCQMVLIGARDGKTFLAAVDDVGTRWEDDCIATGYGGHIALPLLRQALEKNPGGLSRAEAMQILTDCLRVLFYRECRAINKFQMADAAGDGVHISEPFEVETNWAYEGYHFEKTAIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHJ6</accession>
    <name>A0A088RHJ6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_020400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009371">
        <property type="protein sequence ID" value="AIN95220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698185.1">
        <property type="nucleotide sequence ID" value="XM_010699883.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22571850"/>
    <dbReference type="KEGG" id="lpan:LPMP_020400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_020009000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_020400"/>
    <dbReference type="eggNOG" id="ENOG502SHRN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267783at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="751"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="947"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1158"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1316"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1521"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1583"/>
            <end position="1686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1869"/>
            <end position="1888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="602"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="645"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="751"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="767"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="832"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="861"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="961"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="979"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1084"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1212"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1226"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1256"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1331"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1345"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1403"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1425"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1461"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1608"/>
            <end position="1627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1872"/>
            <end position="1881"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1979" mass="206156" checksum="26957E62412B422A" modified="2014-11-26" version="1">MQSRSTCARRPRGGSGEGTTRPSLRDHTSPQRQRCRLSKSAEETTEPVPTCTASTAAAITSSPSMRATATSLALSIPHSRNSAALEAFSLSFQNCLHRQEILFQRVDAAVAQLEGARVNAGCGTSFPSPLHEVGVTLFSSFPTPTGPARSTGPLPRYALPPYHLSPYSPAAAEAGVPLAQPNTTITLPGIVAGGRSSGTAAGIASYNSHMSGPPIPVVSLASPVLSVSSSLHEFPFADIRHNARRRPPSQSSASSTLSLSVVVMRPALERIGGSRGAATAGYPSSQGHLSPLPQTSSHLELPTYVRLDGAATTPTQATPSRLSHPLALFPSSTPAAPLSLARLADMQQQLLTSNTGCTSSTPRNTGVASPALGSAAAVAHTSPLSFSGGGALGTQRYPVAEADVITGDPATEAAALLASVEAASSHEEAMSCSLVSTAVETSAPGDAWRSARSGLKSSTASESSTDRSDSASPARPDVQTPYPATTISAADKSFNSCCCCCGGAESDRVPTWSNSLPGHARDGNLRLSDIGDSSVMSVFSESAESVSLSPLSHLPSIWVGTPRARSAFGQTSPLQPPAPLQQNSSLGGSGINIAWMPPHLVSNSHNSHNSHNSSNAAGTKQAPADQSPSAEAVSEHPRHTPTVVSSSGSLLSTSQQQLHHRGSAEVLSPLSAPCVLSPSSTPVVLPRASDVVHCSSVQLTSVSLSGSGIPLVSANSSGGNAAGPAVMDGNIVSSLSSTSPLMPLVLSGSGCGSTGGGGGAVEDAAQEPTSPLTTCRQLTLSPSRSAEEVNGDDPFPESSLRSSVGSAKEVAAEDAELQRLAKRYAPPPPPQSLTELQQQQNQRRRWSAPPVPTMRRPPMAPLRLPSAASPAAAARDEEERLRSATPLGVKPEEWLSFEQQHERLHLPECWRDSEVVVVDHVEKSRESDTEEAARLLLLEEELLRELRQSQSGQMGSDGLPRRGRRRGSRRRRLMVGGDVTDEAIGEGEVDWGDDSADDAAADATYEARLASYGKAMLLYRSSRFHASLYRGGGGGEESSHGNSPATTVGCCQRGPVSGGDRRGFTPGTTNPSRGESDGDCTVSPAATNAHAGSSAPSKRIFSRRHSAPATIWSSDNNAEWRDLQARFDELISIQQRSRESERDGTDGTTPDEQLLAPLASTMASSPMKEGPASGMPRRRRSRSCSHELTACPPDVEGARAQSASPLTGDLSNDYRSDVPHRGDGGSTSSASSSRVAVATPMPLERTHTHPSPSGYRHVEQERKTQADAAALPPSPTRAKEGISFASLSPYASMTPSPLKQGGSPVQSSCANVLTIRKNSPGFPTSPRHPSMTVNATRTIGTKGSAETHRGVGKHDSDGVKDENLQKSAVAVRKPVEPSTLQTPKSCFAPVSRAASSRGMLGRSQRTVGLPTASTKGRQKPKAARTGRAAAAESRAVAAAVPATRAVSARQRPQASATPMPSALTATSARRGSSAAWKSGSCVSARGPSNSVNSRGGRCAPCSCTSSAFLDTTTAVSIVSTKEADDEAPTAATELRSHSTPHMDTRTILPASPPFGHALDGGEVVEPFSQVLVATTATTAAAPVTVPTTVPPPPTIQKSAQDSGVQRGRLRDNKVNSSRDPDKDHGAHDVLLSSPLQHRQRRHAGAEGEAAVSTRPLHKASARHGPGAPESEARHPDGGAVAGSITTEGADSRALLRRLAEQKRRTRAIEECLRFGVNSAALNNPHNGSHSPRSGNGSGFMWGDGLTIGRWGLEPESCAPSRAVGRGCTVAELARQDVSTALHMYPVHPVIGEATLDTPMTRAITAPYCVGAAADVHHVTVIDPSDAAVVYGTHAAHSGVGAWAVATAQQTSSNPRRRRMDLRLRLSSKLTAPLSSQSASPTKRNKGCAAPLTAATNAAAAASMAPVQSFRRAESLYTTLRSRSPLYSSGAQHASNGDRRRHTIGDDVLPTATLSMSERRLHPTRTPLGSQFVDLVRGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RI27</accession>
    <name>A0A088RI27_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_051120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="AIN95553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703875.1">
        <property type="nucleotide sequence ID" value="XM_010705573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RI27"/>
    <dbReference type="GeneID" id="22572190"/>
    <dbReference type="KEGG" id="lpan:LPMP_051120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_050015500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_051120"/>
    <dbReference type="eggNOG" id="ENOG502QQFJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277324at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="520"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="542" mass="59622" checksum="E2BA659DD739BA99" modified="2014-11-26" version="1">MKTTKQQQRPPLIAIPPPHPTPSPSLSLVITFAHTTVVADAPMKSFFSKIKSKLKTKRKPLAPCDCSDFIEAAPADPSLTHLRSVVVARHFHGAPPPASDVEKARRDFVVRSTMFDLRYRCGAGGRCTCAGAPACRFPQCFAMRPVTKGAEVLAERQVYEVEDAPTPEIRALVALASEEKLDEVVKGIQRTVDAQLKDAARGRGLEARFIIDGSDGHEFTPATPKTGTDSVHAGANPLREDEDLREEITSLYLWRAALLVNLRRDEQAVSSLLNLAFAVEQKDRTRLYGAAAAWAVLNDMEVIYYRSLIKTCKPFDQAAHFATERPLLLTRVFEATRGDDYHTDYCTHVVFSKEVTATVTRAQTAQMHGDFTEDPMRSLCLPLTMPYYRFRVGDEFWKRFYALLCMPPVPPPTPEEAKAQTIDPAAELGLTPNYILDAVGRSMMLHHLVTFADVRDKEIDTGAVADRVKAMKLLDLQPHPSDYAPVLTISEMRVAVARMKELLVVVRSFEAAGPEKLAGAAAARRVQGGGGAANPRAAPPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RI40</accession>
    <name>A0A088RI40_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_060630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703944.1">
        <property type="nucleotide sequence ID" value="XM_010705642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RI40"/>
    <dbReference type="GeneID" id="22572269"/>
    <dbReference type="KEGG" id="lpan:LPMP_060630"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060012000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_060630"/>
    <dbReference type="eggNOG" id="ENOG502SKAH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267346at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="562"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="635" mass="67158" checksum="317FB90E2322AE51" modified="2014-11-26" version="1">MGCNSSKTRRERRRGSTETPEDAAPSELVGSVDPLEPVTVRVSEPVQPRAAVGTNVRGDEGEPESPAQQSAEASVAFVNAPNDSIYTAQSPLEFAANPQSDGGALVETDNVSKNPNVEPDQPASRTSSPKKPQPERDEASAGNQIHSEVESHHSAEKATADEWEVELSLPRSAPPLAQVQQPEAAPVPPLAATPALYDEEATTPLGMESIPEPTPKRQTPRSRPPSDIATRQHARAVASSNASAPRRYSRKSSVGGSSSGTVRPSGRSSQRAMLQPQAHNGRRPPVRQDCGAQAEAASFPQYASAAAPLSPTASLVSASATPVIREELIPNTEVSERMVADYHSPDANHDEVASLQGAGRLAYRESPADLRMSFLQRPPKPASQRWWRGFTSPIPYRRGYTNPTPGAGPQAHRPSTTYMPPPTAYIMRAPGAAPPRLSFDPSALAAMEAPNTRLVQAPILRLADTYTGTATSMSANSGGNEESIPTSQHSAATSMSAVSASRLSGSGADAYIYEGPEKFPPSYLSEPVYTPAAPAAGATGAAAAVTQPSLGAGFLHSHSSQRPRLANPAPRAQQQQRSSEGLYATEQPPQKHLFSRSGLRVRAAVNRAANHYGYDVDAVDAEGSCDTASELYVYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RI66</accession>
    <name>A0A088RI66_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_060730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703954.1">
        <property type="nucleotide sequence ID" value="XM_010705652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RI66"/>
    <dbReference type="GeneID" id="22572279"/>
    <dbReference type="KEGG" id="lpan:LPMP_060730"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060013300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_060730"/>
    <dbReference type="eggNOG" id="ENOG502SBI2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267874at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="704"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="782"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="886"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1019"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1080"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1121"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="713"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="903"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1033"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1121"/>
            <end position="1134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1169" mass="122372" checksum="F7C68485F4CD74AC" modified="2014-11-26" version="1">MLHERGPGAGPLPRASQPSGTFSLSRDVAAAHHRACLTTSGLFAGRRATEAPVCPPALNTKPAPTTRLCNTADCPSIKCPPLWTILPDVGGAASAFLSCVHNTSGLITAATATSQYPSTWQALLEETQATTAYSASVQQAKQLLSDFERYQCSVGAPPLTHDQRCAACPLDSFESGGGAACTTSRPHLDVSALGSCGAPSAAISTGACGSVGNVATGHAAQPLQASPSSSSYFNFQLDPAAFELARQRSLEMLYCNAEARTAYAAQGLQLSRAVCTELLKQPRVAIDDVVAMEGPSIHPTNTAETQSDREVFSSAAQTGDELRTSHTSASPLVANDTGPKRKQSLVAAVPVMSEVERVAATAEAERALSLLYTIRAVRRQTEDLTMRLLHACGEWGCWSTPTANFGPASDQMRASSPSSPLPECPQRRQCLFADLFMPESLTSTTFRTPPSESLPGVSDGSSKAHLLALGEADYTDTARLSAVGAFAKESVCRRERACRVLREALQQQQQRWSLSTTATSADTTTAPAAGAAFLEMAVAPPQRAVPPPPPTSVQLEVYALQQGALRGSICPWRERAAAMTTTSVLKAADASPVREAAAPCGPAQQELYNRSTQRRQLQDSYDVPHAAAVQCHHMSTHSPTGKQLEVQPRETTATFIEDVAARAVTHTARGTSEVVSDASPEVWAPAPPSLLSPPAAVPDMLSRVPSSLAEQHSSTVSSRSSHASPPSEAPLISSVQLAEDCTRAWVNLPTALEASASSSPSPPRRADFLRAAVTSPIDTEISERGAGVPAQQAEQPAVEDTSSRCTKGKPELAVRIEVQATTENTDGSHAAACASSANPTQVTDVLRTSLSSSSLTNFPPSAALDAHDVVGAMPKVYEASRSLHTAARLSTHPETVAGPRREGQHRKGRRRRRGDRRGNTAVAELEDPVRRHLTRLTSQHQKREECDVATPLSTELTPQDLRAAAAAARLHATSSGSAISNAATAPPPAVARHGAHVLAGFVAPSSCSVVRAVSTAAAAANADQPDGGEEPRASQQPHQPPSRTISSTAPPPLPFASSFPAPQAAIFALWPPPHSVLADAAPSHSPMSSMKLPEGGSERVGNASIATPSLAALAPVSTAHPGLTPTSGPPLLSLHKPKLADGGGPAGVTKLPQRQRHRNFFSRLFSCGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RI94</accession>
    <name>A0A088RI94_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_060980</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703979.1">
        <property type="nucleotide sequence ID" value="XM_010705677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RI94"/>
    <dbReference type="GeneID" id="22572304"/>
    <dbReference type="KEGG" id="lpan:LPMP_060980"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060016000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_060980"/>
    <dbReference type="eggNOG" id="ENOG502SEDZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042799">
        <property type="term" value="F:histone H4K20 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045814">
        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46402:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-TRIMETHYLTRANSFERASE SMYD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46402">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="8">
        <location>
            <begin position="184"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="9">
        <location>
            <begin position="225"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN95657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="503" mass="54424" checksum="B23F5C1D50B5109B" modified="2014-11-26" version="1">MTRLRAARAAWYASRELDAYLHQRAWHWTVKRNYALAADFCIRLLNRHPQDTLGLVLGEVAGRYTSQDTFAAKCTQALQESCQRKGVAGVTELVQRTLATTTVASPSSSSAMATSSFTQLPSAEDVLALQAEVAQREADTHDSGADTSGLRGELLYVHNSEPADSVNQAVRRSCLRSATPPLAELLEPFQTTYGRGLYATRHIPPRSSILSETPLLVQRCDDTKCAHCLAPLRPRSHSSITSTTGVSDPHAFGVACPHCEQETYCSVDCRDAAWAQYHACSCASRNPELAQWCEGMRELLQRSGTAAALPEPDKAGIAISGSEASAALSCLTVAKICSMATIHQVHPLSLPGLSCLRGTADYEPATALSEVGALAVALSAALRQPNLYMEEVLSLFALLHTNEFFTTSGIALYSVLSMLNHSCDPNCALVSSGTSPAAGRHGPMKHGSAMEKTLVALRPIRNGEQLLIDYNAALTTKLGYKERKALCAQRHFECYCSRCIRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIG7</accession>
    <name>A0A088RIG7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-ketoglutarate-dependent dioxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_061040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703985.1">
        <property type="nucleotide sequence ID" value="XM_010705683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIG7"/>
    <dbReference type="GeneID" id="22572310"/>
    <dbReference type="KEGG" id="lpan:LPMP_061040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060016600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_061040"/>
    <dbReference type="eggNOG" id="ENOG502REV2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="445341at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42256:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42256">
        <property type="entry name" value="OXOGLUTARATE/IRON-DEPENDENT DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="313" mass="34524" checksum="0B9C5A2A4CEBE1AA" modified="2014-11-26" version="1">MVVSQTSTTADGPWKSSLLRQRVAAGADFQNVALSHAAGILHSEAARVDAQLIDDFSSILRGNVIYIHNFISDAKDMRLYDSLKEELVASTGANMLGNGGLTEWSKHHVFENPTGISQTFNDIIDMLAEYFDVDVYATRLNYYRDGTQWKPQHHDSHAYGGHALREDFTVGLTLGATRSLLFVHEASQREFNFPQMNGDCFAFTGEVNQLFTHGVPRMHTPTTDRFSIIAWGRRRTLNERNGGVPSSAAVQLKGCPINTMEDAVEVAKQLVTAQPGTTAVKKAAPLPCTSGEESHEGHTVALRPAKRKKNRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIY7</accession>
    <name>A0A088RIY7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Electron transfer flavoprotein-ubiquinone oxidoreductase</fullName>
            <shortName evidence="18">ETF-QO</shortName>
            <ecNumber evidence="18">1.5.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">LPMP_070640</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Accepts electrons from ETF and reduces ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 18">
            <text>a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + oxidized [electron-transfer flavoprotein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24052"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.5.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="18">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ETF-QO/FixC family.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.1" evidence="18"/>
    <dbReference type="EMBL" id="CP009376">
        <property type="protein sequence ID" value="AIN95750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704072.1">
        <property type="nucleotide sequence ID" value="XM_010705770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIY7"/>
    <dbReference type="GeneID" id="22572399"/>
    <dbReference type="KEGG" id="lpan:LPMP_070640"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_070011600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_070640"/>
    <dbReference type="eggNOG" id="KOG2415">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="437331at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000015">
        <property type="entry name" value="Electron transfer flavoprotein-ubiquinone oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040156">
        <property type="entry name" value="ETF-QO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049398">
        <property type="entry name" value="ETF-QO/FixC_UQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007859">
        <property type="entry name" value="ETF-QO/FixX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617:SF107">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21162">
        <property type="entry name" value="ETFQO_UQ-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05187">
        <property type="entry name" value="Fer4_ETF_QO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 18" id="KW-0274">FAD</keyword>
    <keyword evidence="5 18" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12 18" id="KW-0408">Iron</keyword>
    <keyword evidence="13 18" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 18 21" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 18" id="KW-0813">Transport</keyword>
    <keyword evidence="14 18" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="ETF-QO/FixC ubiquinone-binding" evidence="20">
        <location>
            <begin position="233"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="ETF-QO/FixX C-terminal" evidence="19">
        <location>
            <begin position="474"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00052682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU366068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF05187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF21162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="AIN95750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="574" mass="62978" checksum="C0AD6FCA13AECEEA" modified="2014-11-26" version="1">MLRWTSRYLCAAAAAAGSEVHRDIEEFAVVVVGGGPSGLSAAIRLKQLAGDQKDSFRVGLIEKGSEIGAHTLSGACVEPHGLDELLPGWREQEGSIFSNMTPVTTDAFHVLTGPSRSLKMPWLPSTLHNRGNYITSLGGVCKWLGEQAEALGVEIYPGFAAADVVVDEATGAVTGVQLNDRGVDKKGRQTAQYEPGMIFRAKQTIFAEGCRGSCTKKLERRFGLRTADNPQTFGLGIKEVWEVPKERHHPGTVMHTVGWPTTDKGHDNTYGGAFLYHYGDSLISCGYVVGLDYSNPYCRPYMEMQKWKTHDLIREQLEGGRPILYGARTLVEGGFSALPKLHFPGGVLVGDCAGFLNLPKIKGTHTAMKSGMLAAEAVYEDAFKGGKEEAASGVECKSYDDYFRSSWLYKELYTVRNVRQSFHKSFTWGMVYTGITSLLVKGREPWTLQHSTPDNLSLKPAKDCVEIKYPKPDGVLTFDLLTNHSRSGTAHNADQPCHLCLKDPKVAEEVNLKKYAGPEARFCPAGVYEFVNDRLVINAQNCLHCKACDIKDPTQNINWTVPEGGGGPNYQSQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJ11</accession>
    <name>A0A088RJ11_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein-tyrosine phosphatase-like, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_090560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN95972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704294.1">
        <property type="nucleotide sequence ID" value="XM_010705992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJ11"/>
    <dbReference type="GeneID" id="22572626"/>
    <dbReference type="KEGG" id="lpan:LPMP_090560"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090010800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_090560"/>
    <dbReference type="eggNOG" id="ENOG502SM82">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273181at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="466"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="577" mass="63216" checksum="775C725080075AFB" modified="2014-11-26" version="1">MESTDASTNYNAHAASAFNLAEREERLVASLEAFLHAWAEGKRKDDRWHPVSSTTTAAMVAREDEQQQRAGSQPHLMLCASNGDAALHTTARMVATPSTSTSTMEYLATLPPCLPVPLPRSFRPNEMMPGVYLGSWSDIGINVLELARRLSDASTSTYESSLCPGSRSRQRLVLLVRACPLKGIVTPRLELRVTWRREGTRRSRLSTGKAVPAPARLLQQPSKRPLATHSGQRPDEDVVVSHMSLNEVYKRVCAVVATEAADLTVAAGVRRAEVMGSRESEDYHHAGPRTGASSSAISSGVSTVARWLCPDSPLSSPSRSALPDRATAANVPSGCTPADWRVFVRAMQWVLTEEASVYTPAGAALKREEVAETAAETAHCRCSGKATAELRYWRLILPILDSPGTRMQHYTPMTTLIMHAALALEEHPQGRAWLQGQQRQVVRNNAPASDGRAVVVDIAGDVGRCEEKSAGAAEAIVFPCVAVHCQAGKSRSVAFVAAFLLQEWMWWYRGCYPLITAGTDTITAEQQQQQRSRQGNIARRLVDTVLSHLRRRRLCIDINLGFDAQLWEMMGAFVRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJ59</accession>
    <name>A0A088RJ59_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mitochondrial RNA binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">MRP2</name>
        <name evidence="3" type="ORF">LPMP_091120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN96027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704349.1">
        <property type="nucleotide sequence ID" value="XM_010706047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJ59"/>
    <dbReference type="GeneID" id="22572682"/>
    <dbReference type="KEGG" id="lpan:LPMP_091120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090016700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_091120"/>
    <dbReference type="eggNOG" id="ENOG502S3GK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271781at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009044">
        <property type="entry name" value="ssDNA-bd_transcriptional_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032680">
        <property type="entry name" value="SUN1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09387">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54447">
        <property type="entry name" value="ssDNA-binding transcriptional regulator domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUN" evidence="2">
        <location>
            <begin position="59"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="242" mass="26699" checksum="4CAFDC59C698020A" modified="2014-11-26" version="1">MLRRLPTGWALRNGAGVTTMAVAGGLSANPSTFACKAPLLQPARWASSDAAAPTPVIPQRHNSRSSSVQGQRGRRDDLPPAFDVVHWDDANITAGHLLRVAYRDGFIVLDYHRQRSATSALREDGSRAVNPNRAERVVTVTLPPVYAARFLGVLEERMSKLEVQSRFTKASFLPNTAKGKHHYTLHCTSMKPTTGQIQTADGADVHEETVEWTVEFNAAESLMLHRFLTQALHYNTGFSRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJL5</accession>
    <name>A0A088RJL5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ZC3H15/TMA46 family C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_100720</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696795.1">
        <property type="nucleotide sequence ID" value="XM_010698493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJL5"/>
    <dbReference type="GeneID" id="22572809"/>
    <dbReference type="KEGG" id="lpan:LPMP_100720"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100013600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_100720"/>
    <dbReference type="eggNOG" id="ENOG502RYB1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="278280at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032378">
        <property type="entry name" value="ZC3H15/TMA46_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681:SF0">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681">
        <property type="entry name" value="ZINC FINGER-CONTAINING PROTEIN P48ZNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16543">
        <property type="entry name" value="DFRP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZC3H15/TMA46 family C-terminal" evidence="6">
        <location>
            <begin position="124"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="36"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN96142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="221" mass="25901" checksum="9FB4E7EB6F86B5CC" modified="2014-11-26" version="1">MGKAEQKKKEKIVEDKTFGLKNKNRSAKVQAYVQQVRQSVDQRNPQERKSQSELAARRSAKEEKRAREAELAKLFNDVDQQQRKKLDGAKVEAADGDDQYMCNPEEYLFRPEDFDEVEKDDERLEEKLEAEREKLKDRTDLTPVTEVSFQAWKQRKREEAAEMEAARVRRAKSGDGKLRGWDLWQMDQELFVDDENADEFYEREALEDLEGGEEEAAFDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJW0</accession>
    <name>A0A088RJW0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA-binding protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_100930</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696816.1">
        <property type="nucleotide sequence ID" value="XM_010698514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJW0"/>
    <dbReference type="GeneID" id="22572830"/>
    <dbReference type="KEGG" id="lpan:LPMP_100930"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100016100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_100930"/>
    <dbReference type="eggNOG" id="ENOG502RXPW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21467at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46754">
        <property type="entry name" value="MKI67 FHA DOMAIN-INTERACTING NUCLEOLAR PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="165"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="44"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="356"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN96163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="390" mass="41966" checksum="F3CFB7882BBBB5D2" modified="2014-11-26" version="1">MPPKSSLKKANRAAATGKRKKLSFAKSTVKAAAEAIQTTHINAPVGTAARHAPPAAVLRKKGRQVKAATKTVSSATKKRSGIVKAKRAKKDEAARPAPSDEENSSDDEDDMLNGGTAVDYDADNLSEIVDSSALDDEDDEMGAGKQASSPAPRQRDSNGAVEPYRAVRLSFLPSEFQEPQLCKFLSQFGATVLSCFCVRSKRSHRSRGIAYVKFDRESVIPLVVEECNGMALGGMAVRARAVTMRRPMPSRQMVSRRRALAYAYKTKGTPLKKHDVRRKNPVGLLIKAVRTERENNNYLKSLGIDFETDLFKSQLATLPPGLLKKKRPMSGKPKDGAVAAAGVGKAVVTTTDVTAAVPMPSLNQATSKASSPKAPVNKPEAKRSVRAKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RK82</accession>
    <name>A0A088RK82_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_130010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697085.1">
        <property type="nucleotide sequence ID" value="XM_010698783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RK82"/>
    <dbReference type="GeneID" id="22573111"/>
    <dbReference type="KEGG" id="lpan:LPMP_130010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130005200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_130010"/>
    <dbReference type="eggNOG" id="KOG0266">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051350">
        <property type="entry name" value="WD_repeat-ST_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838">
        <property type="entry name" value="WD REPEAT PROTEIN 26-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="407"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN96432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="650" mass="70842" checksum="DEC9C6780E189E31" modified="2014-11-26" version="1">MSFQAVPSSGGLSDAGGPARAAFTPTSIVDIEPNDVTRSEMVQIIVTWLIEAGFTSSAQILREEATSQFRGEHYLRKTLRSLSRAVEESSWDSAQRSLKKLQTKAATKSGLKLEGTSPAALLVRSLPFLLAQQQYMELVEKDNDQRTFAFFMRSIKPFERSISREHFQKLTYLLTCKTVAESSNVYPEYRGWTAELGRAQLLQHIRTQVGSVDYSNYCRHGNVCIPPPVELTRPLHTIFQQSFSYELLSHQHPDLVRRLPRTTITSLSAPLESQLPATEPFISIDTSALVRSTFPALAPGDVRQCVKLTACQPFLSHGAVVAATDTGAVLWIPTGPLCNSDASAPSFESHAADKAQLLYHHKRPIRDLRRNGTKLLCWGSCQTLVLNVQPLLDGGAAALASDCVTCVFTHAADVYAGCFFPCGTLAVTGLSEGTVCVWDLNTSTKLYEHLFSNHGVVSLVLNRTGTSYFAASKDGTIRVVDVSTGVLTASLVSPIAMEICSLAVSPSSTFLLASYRGGLMRMWDILTGELLPYRFTGTEDNTKARSPTSFGNTDAELFSGGEDGCLYFWNLRLRDRASKPVIPARAAEAPRSGNLYLSQAGINGNLVRYAAQLPLHRLPITDVKVEGPYEVSCGEDGIIVLCATCASTHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKB0</accession>
    <name>A0A088RKB0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_120400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009381">
        <property type="protein sequence ID" value="AIN96368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697021.1">
        <property type="nucleotide sequence ID" value="XM_010698719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKB0"/>
    <dbReference type="GeneID" id="22573046"/>
    <dbReference type="KEGG" id="lpan:LPMP_120400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_120008900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_120400"/>
    <dbReference type="eggNOG" id="KOG4039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="430436at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051170">
        <property type="term" value="P:import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097:SF7">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="43867" checksum="6AC9FFEBC63F284A" modified="2014-11-26" version="1">MTSMIVAGATGAIGRTVVQNAIQQPSIYQVVALTRLKNTAASNYESLFGIITAGEASNTDNGGKGVSRKGKTGSGSPADTVTVTPEEAAKIKPITIDWEEFTQLWVAKRNSASAAARGADNGAADAAAADPTENYRSIFSGHTYAAMCLGTTRKDAGSAKNFIRCDYDYVTAFTEAVLTYSAPAGLSPDTAFMHHIGDEGVSKQARVQDSVDSEMNVLATVKGNAGQSSGTLRVFCQVSASSASSSSWFLYVKTKGIADESTVERVHQHNKLTTASATLSPVKLLLLKPGLLERRGKARRIEKLAKLIVSPIPVETCGAAIVSACKHSPIQHHMQHPATISAAAEQAKHDEAEEAQLKKGDDVIAANIRKMPLGKPYMPTKAMHRAGAPSNEPFPHIYEATNPMIKDLASRLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RL54</accession>
    <name>A0A088RL54_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Serine/threonine-protein kinase, putative</fullName>
            <ecNumber evidence="9">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_150180</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="9"/>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697395.1">
        <property type="nucleotide sequence ID" value="XM_010699093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RL54"/>
    <dbReference type="GeneID" id="22573434"/>
    <dbReference type="KEGG" id="lpan:LPMP_150180"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150006800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_150180"/>
    <dbReference type="eggNOG" id="KOG0667">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF28">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MINIBRAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="362"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="96"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="687"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="147"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="182"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="259"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="697"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="721"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN96742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="745" mass="80719" checksum="2B25A50BC3CF6A34" modified="2014-11-26" version="1">MADSSKATLSQMSTETLLQQLRGMRTALEEENHAPYEAEAEATQVDSSHRHHHYGNAAVVGVSWYSSDVAHVSHSESSAPREPVMEPREARVVDAVPDHARSKSSGSQISASTAARPRPSSSQLSPHTTGDGFSVSSVRSLPDAHADPTAPSVAPVTPVVTDGSDHSAVSAPTKGRLSHVHAAAAAGAPSSSASSSTTGPPPLTVAPLGGARTTTAAKEHPLAPATTRTRTGFSNGEVPPHPGLAASTQAGAAPPPSLPLLSSSHPTTSSAAATTPATFSSGAVVKEGSGGGAGVSASEETDPYGRPAIALSVHLLDLYKMVNARYCAQRRLESPGPKYNSGYDDKDGHYLFLPGEVIFQRYIAQEVLGKGSFGTVIRGFDQKRSEAVAMKITRRGSSFRSQAKLELDILLRLNENPALNHLVVRLLKVFEWQGHLVLVFELLSFNLYQLIKCTRFNGVSLDLVRKFAYQLTHTLLQLESQKPQPIIHCDLKPENILLRSQNRSGIRLIDFGSACYAAKRFHRYIQSRFYRSPEVILFLEYGTPIDRWSLACVLVELHTGVPLFDGRTEAAQLAKIEATLGPIPARMVAGSPKANRFYYGNVTSGFQLKEPVPERRTLEGIIGVTTGGPRGRRLNTPGHDEQVYRDFHDFIAGFLRYQPEERMNCRDALQHPFLMPLYTSDLQLQKNREDAQPVAAPPFSQQQQQEQPPQSSQSSQPQQQHMTVATTTKPSSVEHSYAPAVLPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RL91</accession>
    <name>A0A088RL91_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_140780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96658.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697311.1">
        <property type="nucleotide sequence ID" value="XM_010699009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RL91"/>
    <dbReference type="GeneID" id="22573345"/>
    <dbReference type="KEGG" id="lpan:LPMP_140780"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140013000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_140780"/>
    <dbReference type="eggNOG" id="ENOG502S820">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267097at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN96658.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="434" mass="43949" checksum="74024EA6EAA38CEC" modified="2026-01-28" version="2">MDLDAFLNKNNKKNSKKVAKKKSADDAALGGFGLETVPRVSIAAAKPITVANTGGSEASAPASSTSPLPAPEKTAVAPVIAVSLNFASTTRSVKTWDAAKVMHDSKRQEEVQRASEQKAKEEAEATGKKNAAEGDDSEEQSPESSPKEAKVVKFVARGHRNATGTIGGGEGGTTAGGRVALRTQGLSLENLPTLEETFGNARKQSQSPSQQQQQPVTSLPSKEQSGESAPAAAPQETFSSSPTSTTASAAGNKYVPPTKSSTTMESSPTLSSSPTAAHSSTGAYRPPASGSVSAGVYRPPSSSSGAYKPPSAGVYRPPNASAGEAYKPPAQSTPSSGTDPYKPPTASDTSASAYRPPTSTGEAYKPPVPTTAAPSAGTYKPPSSGTAGTYKPPSSGTAGTYKPPSIGSSSAGAYKPPSAGGSASTYKPPNKREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLK8</accession>
    <name>A0A088RLK8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_100050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696727.1">
        <property type="nucleotide sequence ID" value="XM_010698425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLK8"/>
    <dbReference type="GeneID" id="22572741"/>
    <dbReference type="KEGG" id="lpan:LPMP_100050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100005700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_100050"/>
    <dbReference type="eggNOG" id="ENOG502SIZ4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271752at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN96074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="343" mass="36667" checksum="761C8F266E0433F5" modified="2014-11-26" version="1">MSKECDFFSDSYGCIVTKSIGYQAPFPLVRLSNGQSTRTPDGAYVQGSCFVSFGADQTASRGRLLTLDVSVRASSVSFLQLLSSSCPPLALDPDVDYVSKIESIETAFAVVTRGRGNRWSTSVYVQGDGEQVTACPRRAHFRRTSAVSLLGSAVWLVEAAKYDPGTHAVHRYSLATALASGVSESTLVSADLGRPLDVIAFSEDSALVLSTKGVALTDRRQRASDILFFSALLNGGVTGDRQLLTFDEDYTLRAYDLRDVSAPLCEATSASYLRIKSAIGTRASLLVASDMTGVFDVLHMTTIAALQHSGDTVLDAAVLPSRHNGVRVCTSTGSGMVYDWTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLN5</accession>
    <name>A0A088RLN5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Bifunctional NAD(P)H-hydrate repair enzyme</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Nicotinamide nucleotide repair protein</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="19">ADP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
                <ecNumber evidence="19">4.2.1.136</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="19">ADP-dependent NAD(P)HX dehydratase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="19">NAD(P)H-hydrate epimerase</fullName>
                <ecNumber evidence="19">5.1.99.6</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="22" type="ORF">LPMP_141170</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14 19">Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="function">
        <text evidence="17">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="function">
        <text evidence="18">Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 18 19">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 18 19">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 19">
            <text>(6S)-NADHX + ADP = AMP + phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32223"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(6S)-NADHX + ATP = ADP + phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19017"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 19">
            <text>(6S)-NADPHX + ADP = AMP + phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32235"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(6S)-NADPHX + ATP = ADP + phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32231"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18 19">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="18 19">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">In the C-terminal section; belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">In the N-terminal section; belongs to the NnrE/AIBP family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.136" evidence="19"/>
    <dbReference type="EC" id="5.1.99.6" evidence="19"/>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697348.1">
        <property type="nucleotide sequence ID" value="XM_010699046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLN5"/>
    <dbReference type="GeneID" id="22573384"/>
    <dbReference type="KEGG" id="lpan:LPMP_141170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140017300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_141170"/>
    <dbReference type="eggNOG" id="KOG2585">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3974">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10064708at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052855">
        <property type="term" value="F:ADP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047453">
        <property type="term" value="F:ATP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NAD(P)HX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110051">
        <property type="term" value="P:metabolite repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000017">
        <property type="entry name" value="Multifunctional fusion protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10260:FF:000003">
        <property type="entry name" value="Multifunctional fusion protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="entry name" value="YjeF N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01966">
        <property type="entry name" value="NADHX_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017953">
        <property type="entry name" value="Carbohydrate_kinase_pred_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030677">
        <property type="entry name" value="Nnr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00196">
        <property type="entry name" value="yjeF_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592:SF0">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017184">
        <property type="entry name" value="Nnr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="YjeF N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01050">
        <property type="entry name" value="YJEF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 18 19" id="KW-0413">Isomerase</keyword>
    <keyword evidence="22" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 17 19" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 18 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10 17 19" id="KW-0520">NAD</keyword>
    <keyword evidence="8 19" id="KW-0521">NADP</keyword>
    <keyword evidence="6 17 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9 18 19" id="KW-0630">Potassium</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="22" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="21">
        <location>
            <begin position="29"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="YjeF C-terminal" evidence="20">
        <location>
            <begin position="249"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="77"/>
            <end position="81"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="149"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="417"/>
            <end position="423"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="454"/>
            <end position="458"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="485"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR017184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="AIN96695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="561" mass="58710" checksum="457A9E2F11CA001E" modified="2014-11-26" version="1">MLSRISERCTAVTGLEQVLCRHVWSAAWLRDAEPAAAASQSIDLSCLMERAGLAAYDVFASLYASQRHWLILVGSGNNGGDGYVIARHAREAGRKVTVLSMPHSKPLPTEATNAQHAWQAVGGTETMINPGTSLHLPTDVDLVVDGLLGTGISGPPRKHYEEVIRHINALPVPRVAIDIPSGLNAETGEAAGACVKADHTATFICLKPGLLTGQARDYVGQLHYRSLGLEEWMIAAERMDAALCRRVALGDVYGYFSTRRSAVAHKGSCGKVVLIGGDHGFGGAILMSAEACLTIGAGLTRVLTRPEYVAPLLTRCPEVMVIAVETETSGQLEQQMVEAFEWASTLAVGPGLGTGAYGQAALSAALRQAEMHQDKTLVLDADALNLLAERLHSKEVGAAVGAGKYLPVLPNSIITPHPGEAARLLACRVVDVEKDRLAAARRLAAVLGGTCLLKGPGTVVHCQSSGKTAIVDAGNAGMASGGMGDVLTGLLAGLAAQRMMHDTFDTTCAAALAHGVAADMVAAEDGRGTRGIRATELIPRIPFIVNASVPSSATQQRRSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLU1</accession>
    <name>A0A088RLU1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_100650</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696787.1">
        <property type="nucleotide sequence ID" value="XM_010698485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLU1"/>
    <dbReference type="GeneID" id="22572801"/>
    <dbReference type="KEGG" id="lpan:LPMP_100650"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100013100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_100650"/>
    <dbReference type="eggNOG" id="KOG0110">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="439639at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12320">
        <property type="entry name" value="RRM6_RBM19_RRM5_MRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001743">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="363"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="704"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="853"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="123"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="220"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="298"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="467"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="803"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="311"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="327"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="467"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="482"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN96134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="939" mass="101401" checksum="7267F9A688FE8015" modified="2014-11-26" version="1">MSRVRILNLPADCTEEQLKQHLLRTAPRDAPLLEITDVQLIRRPATALDRDHHHKQRRGCLSAVAAAKAPKMILRMAFVGFRTSAAGHFVAQYFNRSFFRSACLKVELAKGLNEVGVTLNQLRKQKKEEEKSNNTNKAKSRSGAADGSHASGLTSSTTAGEQATTRKRARDNDREDGKDGGDTGDTTADDLARRQREFVELRSKATEGPTWAAEVLLAPDNTPTASMGNEAERKCAMDEKTQRHRRRQKAEGHVPDVGNTDGESEVEQERWALSRQQALGEVSDMDFLARLAGAPTLSAAEAEETARREDDADDGASVSEDDGDGNIPSTATNPDSSTKSKELSQVATATTHEAQEEIARASHRVRLGNIPYIATEEHLKQFATSLVGPVEAVHIPLTKDTRQNKGAAFVRFFSAEDAVRALRLCRGAILMGRLLRVSAAEEDPHSKRVMEREAALASTAAAQGTTDALSGANLSGSSQFKKQREADRRGGEAGKEGGGGQITWNTMYMNSHAAVETVAQRLGVRSEDVVGVGAKGAAVRAAIAEAYLASEVQHVLSDEGIACDLLEGATQNLLKSRSNTTILVKNLQLKDGSDAAELTKLFVRFGVLETSAFPSAGTFALFRYTHPQDARIAFMRLSYKLFKTVPLFLEWAPVGALMDDGEGTSAAATAAADLGLAVGPSSESGANADTDDSADAAVANAMVYTLFLTNIPFQTTEDELHAFLLDAGPRLARAPETLIKRLVLQQVQGRAFLTVADQSTLAYCVSKINGKILAGRTLSCVVSKQTTQLLQQARVIDTTSTAQGTTGRLAGANARDDNDDEADATKTAVLARRRGVTSSAATSSEVPPGSDPQKLIVKNLPFEATERDVRELFSAFSEIRSVRVPRKSHTFSSHRENNHRGFAFVEFLSEVEAARALETLKSTHLYGRHLVLQYAKLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLU5</accession>
    <name>A0A088RLU5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 4 gamma, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">EIF4G3</name>
        <name evidence="6" type="ORF">LPMP_161570</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4G family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN97032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697685.1">
        <property type="nucleotide sequence ID" value="XM_010699383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLU5"/>
    <dbReference type="GeneID" id="22573736"/>
    <dbReference type="KEGG" id="lpan:LPMP_161570"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160021100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_161570"/>
    <dbReference type="eggNOG" id="KOG0401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="514777at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253:SF9">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G" evidence="5">
        <location>
            <begin position="60"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="290"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN97032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="636" mass="70971" checksum="ADA81AC50BE80A37" modified="2014-11-26" version="1">MQFTVEQIRSVRNNYLEPPYPGFSLDEVVRRRRLTQTKLVRGENAWVVKGTAQTTEEWAQRLLHGTLNKLTEENRDILVGKLLTKELFATEDIMNMVVKIIFKKALDEPENSKLYAGVCHSLALYEATVLRDGHKGERPQSQLRDAIIRTAQYEFRTLSQELSKMEDKSEEELEYERSNVMRRKRSNMRFIGELYLCTALTHTTMFTIMDLTMRCSDGTGFPSSENIELLAALLSTIGDRLDKSHKTTLDSYFTSLENFNKKPDCTYPPRIRFKIMDLLDLRKCGWGSKPKPVKAALPPSHGKDKKYASAPPPKKGGRDQGNAAAAAVKSWRDAATAKTGTMAAPAPSAGKGLNGRGTSSGALAANTTTLSTSAAVTSAAVAPAGAAFRGEASPPAPLVKFELRVASMFQEWVADRTNDVILQWVDQFNTCDRFFESESELCVAVAQEVIHSACTTTRKDAQRAAFSFLVVGLYMIDTEVFDGFASALASAIEDGLLEDVPKFGERFMSMLRLTSTEQETRADVYFDAANVLRLTYNRLESPDDYAVDTLMSFWDRVPLPSTDEENMIRMDLDVVYSMCNPEGAQEGLEKLLSRIIHSMLQMQLMDAEVLAEFLCLDVEEGLCAKVIADYKARVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMA9</accession>
    <name>A0A088RMA9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Regulator of chromatin condensation, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_170200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697711.1">
        <property type="nucleotide sequence ID" value="XM_010699409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMA9"/>
    <dbReference type="GeneID" id="22573763"/>
    <dbReference type="KEGG" id="lpan:LPMP_170200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170007400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_170200"/>
    <dbReference type="eggNOG" id="KOG1426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="16281at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF408">
        <property type="entry name" value="OS09G0560450 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="236"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="548"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="601"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="680"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="738"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="821"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="874"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="78"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="340"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="349"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="381"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="411"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN97058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1243" mass="129132" checksum="9036F8EA44B3B62F" modified="2014-11-26" version="1">MRSEDTSTANSPGLGGSTNLSRRNDTRSNSSSSSSGQRSFPHVDSAYYHDIINPAASSPFPDAAFTTATAVAGNRALTGASSSSSTMHCAASSGGLYSSAADASSLPQHLPPRWLRQPGALSPPQTPRPHDQQQLRLATPQPSTHAHENTEAATVASRHDCLESASSLPHADGRIAAAAIATAVPEGSSSSPHRRSHTRSEARLSPPSAAHRRTFYFRPVRTAESVCVATTASSSEWVLLNVGGRLITTTVGTLMADPDSVLASLCACLMSSPRRSDSVAGKKSGSHRRTVVTSREVSGRCGAVAETTFPEEEVPGGGARCSSPGRDIYIHTADLADSRDADGLRNRSSESGGASAAGAASVGSVCASPSPAAEYGLSRVPQHDDGGVQHGGDRSSPFSSLYACHRPTHRSTTSAASTSTSPQSPLKHLSPQQSLRPAMRESRPDYVAAHTTPPVSLPVNISVGEGGDGEAVSPQQTASTIPLDTDGANAILLDLDADYFLPVLNYLRHGAVIIPHQLSVAGVLAMAEYLNVMGLVRALRRPQMPRRVMLFSWGSGSNGELGTHATRDEPTPTMARVTPFGVRVCEIALGANYSCALSDTGSIYTFGSGEWGQLGLGGSGCPVRGGSSPPGGGGGNGVGQDGVEAPVEVLTPRRIPLFEQLPAVHVAAGYAFAMAIVGGHHVYFWGNNNHGQSGRGRSHFDLSTKKVEAPVLVETLEGKNIIQLSCGSFFALALSADGSLYSWGLVDCVGLGTPEEVERRYHGVLGESLSNERRAVVLTPQLVTVKGRRRIAPGGATVTVPERIVRICAGQWHSGAINEHGELFTWGVGYQGRLGHGSKTPAYVPTLVRGALEGHRVVDVACGSFHTVALTAAGAVFCWGDNASGQCGTTAGSPDAFTAPYRVVGLEYVAGGVARSIACGRQHTVVVMEGPQPWCPQPCCRVDSAEFGCHSHAQVYCFGEATRTANASGSSGSSVAAAAVSGVARGTVSSGHLGLPMAAISASALPTSPSHGPFMTGGAAAVLPTSLPLPWTGGHHHPHYQLVPGLQIVDVRGVVSGLHHTFAYVEEICADAPRVVDCFVDAPSATARGWEHRPSYTPCLPPLLPLQGASAAESHVSHSAFAWGPSSSSGSGGATISWTRSFAPPPLASQRLLSAYRDPWSDAPIESSTDNISGRITPLTRARTMHARLWSGGSMEAPFPGAASQQQHHHLMSPLARREAAAYVEVSGTTDGEGRHGGSAGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMD1</accession>
    <name>A0A088RMD1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_171290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697820.1">
        <property type="nucleotide sequence ID" value="XM_010699518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMD1"/>
    <dbReference type="GeneID" id="22573872"/>
    <dbReference type="KEGG" id="lpan:LPMP_171290"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170019100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_171290"/>
    <dbReference type="eggNOG" id="ENOG502R178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275363at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="241" mass="27303" checksum="C6FDE623C287E3EA" modified="2014-11-26" version="1">MPGLSSVWRWLRGEPAIPGVVYSDQLQNVKEELECQQNIRWAGNLRNVRLESAPDLIVRTSSSTAALPGPEAEPYTFWERIGLVPVHPSRVRARQYYHPITDFALYDYDEISPEEKELTARWMARVMEFNGATPAGILCAAGCVVLPLHTVYRMPLLVAAGITGVAVEVTRAYMAASQQRQDLDDFLLAKEIWYIKNVETYQLGLPRIPRGREREYQQYVDGGGSMQSQDLPEELARDLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMJ3</accession>
    <name>A0A088RMJ3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phosphatidic acid phosphatase/haloperoxidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_180710</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697905.1">
        <property type="nucleotide sequence ID" value="XM_010699603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMJ3"/>
    <dbReference type="GeneID" id="22573961"/>
    <dbReference type="KEGG" id="lpan:LPMP_180710"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180010000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_180710"/>
    <dbReference type="eggNOG" id="KOG3030">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8907274at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03390">
        <property type="entry name" value="PAP2_containing_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF35">
        <property type="entry name" value="RE23632P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="101"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN97252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="307" mass="34165" checksum="A594307C7053DC2F" modified="2014-11-26" version="1">MALKRLVHHFFLWRAPDYLAVAIMAIVASVVGSTVRPHCRKVDWSDSTIGHPFTTKEVFPMYSVVIAVVLVAVLYIAGELFTRWGRPAGRLNMWLHVNGWVLAHMWSIGLAFVLVNLSKLYAGRLRPDFLSRLGREGITEINWATMTHDAQCRAAREGRLSFPSGHSGTAFSGYVPPCMYLMGLLRTLKGGRLWLVTLSLLPLIIPITIAISRTTDYRHNFDDVLAGSICGALCGVLSVVVSFRPSMLGEWTLRDHSDDKSETKAPLMCLVEEVVETIKRSESVVETTTLQHPLSPYPPRPVVINKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMU1</accession>
    <name>A0A088RMU1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Intraflagellar transport protein component, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_190300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698025.1">
        <property type="nucleotide sequence ID" value="XM_010699723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMU1"/>
    <dbReference type="GeneID" id="22574084"/>
    <dbReference type="KEGG" id="lpan:LPMP_190300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190011300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_190300"/>
    <dbReference type="eggNOG" id="KOG3861">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10259368at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23683">
        <property type="entry name" value="IFT52_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039975">
        <property type="entry name" value="IFT52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055460">
        <property type="entry name" value="IFT52_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055458">
        <property type="entry name" value="IFT52_GIFT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048643">
        <property type="entry name" value="Itf52_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12969:SF7">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12969">
        <property type="entry name" value="NGD5/OSM-6/IFT52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23352">
        <property type="entry name" value="IFT52_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23355">
        <property type="entry name" value="IFT52_GIFT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21178">
        <property type="entry name" value="Itf52_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IFT52 GIFT" evidence="3">
        <location>
            <begin position="40"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="IFT52 GIFT" evidence="3">
        <location>
            <begin position="242"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="IFT52 central" evidence="2">
        <location>
            <begin position="366"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Intraflagellar transport protein 52 C-terminal" evidence="1">
        <location>
            <begin position="457"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN97372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="672" mass="73398" checksum="0B303184545887FA" modified="2014-11-26" version="1">MTEITAANRGKVNEMWLNAAADGKSEAAAAPPPTQHTKLCFNTCRQEQYHPNKGYRHLARKLRQGGTVDMNKEDITLDRLSANDIVLFPAPQTPFSEGDIKVIRQYVEGGGSVMILLGDGHGGQYSYLNKALEDWTGITINEDCVVRTVLHRYLHPKEVRVTNGITNRAINKAAGKNVFGAVGGLPRSAFGGGAGSAVAKGTTSTMGLGSTLTTLNRTLGGGQATNATLLAQGPPAGGTVAMAGEEAEQEATSLVFVYPYGLTFNVQRPAIPLLSSGFMAYPLNRPIAAAWECPKVVEHLGRQKQGRLLLIGTAQLFDDAWIEKEENSALASVLFDYLNHRLKLNQIDADEPDITDYHHLPDTASLSERLRVAVEQHEELPRDFTQLFELDSFKIDTDKIPDVVDTYSKLSVKVEPLTLIPPEFQTPLPPVKPAVFEAIHRDPPAPGLDLFDLDEEFAPERVRLSQLTNKCKADDVEYYILQAAEVMGVTKKLRSPRNRDPRALLDYVFRQVVDYKKVNNGPVASQEARLGGTTGEAGADNAAAAAAAQNMMRVIRVSNDGTGDATPFDENPRWSLYLEADFAKGTIEGHLQLLRDSSRFGAQEARIEGDIKPPGEREYPMEWGVVLDAVNGEQIIYVFLAVIQGNQLRGVCEQGGSGGGNTRNFLYTLEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RN94</accession>
    <name>A0A088RN94_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_190700</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698066.1">
        <property type="nucleotide sequence ID" value="XM_010699764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RN94"/>
    <dbReference type="GeneID" id="22574124"/>
    <dbReference type="KEGG" id="lpan:LPMP_190700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000052400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_190700"/>
    <dbReference type="eggNOG" id="KOG2940">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="16816at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050602">
        <property type="entry name" value="Malonyl-ACP_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090:SF1">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="63"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="358"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN97413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="385" mass="43709" checksum="FBEB3126A80EEE39" modified="2014-11-26" version="1">MPSPLVLTRATPARGLNIKMFDRKVKGLQRSFVSSPACDLHKLCAEQMLDRRAFVKRDTPVVLEVGAHTGWYLRHMIERKELHGLKQYIQTDISEERLNRNYEEIKDVLPPEVEFVQISCDEEQPAPFGIPDKSVDMVVSCLSMHWVNDLETAMVNIRKVLKRDGFFLNAMFGGNTLYELRGCFSMAQTEALGGVTPHVSPMIDGAGLSTLVLQAGFSIPTIDLDRHLLLYETPFHLMEHLAVMGESACHYMRQPMKRDVLLCACAVYDTMYRQNGLIPATFEVFHTIAWSPSPTQAKPLERGSGQISLASWNSKNRKQLQSVLDEYALNPDDEVLQNKAEAIFKRLREESADLMAKKGLDSRGFERDRDEEARQLDQKPLPPFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNT2</accession>
    <name>A0A088RNT2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_201140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698315.1">
        <property type="nucleotide sequence ID" value="XM_010700013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNT2"/>
    <dbReference type="GeneID" id="22574323"/>
    <dbReference type="KEGG" id="lpan:LPMP_201140"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200016600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201140"/>
    <dbReference type="eggNOG" id="ENOG502SDRH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273658at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="401" mass="42982" checksum="D391EC43599CAB1E" modified="2014-11-26" version="1">MVQLERWNAYWEAYSTCCADELEGLAKQLEEPSSAAGYRRVLLTLSNPAFLSSSVPPTEATNSATTAPAAPDHLPVQVEDPSFSPISSSREDNKVVGSQTHSPLSTGTAGSACSSSPPPPLPTPHSRETSVSSSSYSYSSSYSSYASSYISHSRSSRNADSAAKAAHADDGIDALSFLHWALDDLLYHYAHRFGAVEHLDTRDSSTSAGALSTSTARVIVSVQFTTAEAAGLFLRWADGLSVADVIAAYRRETQAPETASGGNLLPVGGESVVGTRVTALATGTLKGGTTNPQNELGGCDEAWWNTLEEASRRWQLCLIAKLAPHDPHRIAAKLLLGPNVMVSTPLVKSLFSGLFDVTHMEYRTDLRAFNIEFANKKECRLALHALQCSLWRVFGAPLIFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNU3</accession>
    <name>A0A088RNU3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_201240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698325.1">
        <property type="nucleotide sequence ID" value="XM_010700023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNU3"/>
    <dbReference type="GeneID" id="22574333"/>
    <dbReference type="KEGG" id="lpan:LPMP_201240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200017800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201240"/>
    <dbReference type="eggNOG" id="ENOG502SIIS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273756at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="646" mass="69967" checksum="41C18E5B73617055" modified="2014-11-26" version="1">MSPSATGSPYVCLSTQCDALYRIGAQQHNFAFISEQSVYTRAAEQLRFFTPSPKLLSSVGRPSIGSDRAELCKRAGNDVDPLPPHVYMSAQPPHPFPSIERLEAAQRAALKQKEAQAKVRHRSSTASVMVSGDWAATTSALHDVLVPSGPLLAQRTYRYDYEDRRRKVRIGTTAAAPRRDTLEKTVCSSHKDSLQTSSPLLQLIFPSSVLLRAVAQMVLTLQTSSSTSAARFALAQYRGAELLPWRTRFHEVQEPAAPSTSRLSPEALVVSVLPQVVADRVASRARMSSGQLSSPRYASRDDKHTTTLYALTPSVDLLTNMGTRGAKREREVTQRATQKGTAGNAAGVNVLAGTILCQRLATTTEASAAQAVPVCYAAVSADEFEGWASKAGKGNASPQTLLSTAYCAADTLLYEEESTWMTDGVFHPLFSLPLALPTDSSVVADANTPIMEHNSSSGSHTTHLTFLKTSAFLFLSFLVHRSWCVHVHSAVTQAMAAHQRPSNTGQQTGSSRLVFTGTHVICLPPVHEVRRSTQYEWKSRLIYRAHEMRTAGCATTAAVRPLESNEEVRGGALVASTATKSLHYRPVVWQLEILAVSRNAQLQWCMCNTTLAACVGAGLAVTPLPHNMDEGILNGSGTLSELLEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RP34</accession>
    <name>A0A088RP34_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_201890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698390.1">
        <property type="nucleotide sequence ID" value="XM_010700088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RP34"/>
    <dbReference type="GeneID" id="22574398"/>
    <dbReference type="KEGG" id="lpan:LPMP_201890"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200024300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201890"/>
    <dbReference type="eggNOG" id="ENOG502SM5P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266850at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="686"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="688"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="711"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1083" mass="113585" checksum="513196AEB928F357" modified="2014-11-26" version="1">MQPNMERRVLVYQCGTRSVVNLSETRTCSSPSRSRCLPSESSTTCQGSRPREAAGFLGNTTTAATERSALDSLCSTLTVNTVTDPRDAWWVDGVLSQTALSPSPRLPPPPPPPPPPARCTSHGVNDTIGRPKSARAEALSKRCPHQSLQGMSLSPFVDDVHSCGDSAALPESDCHFSSFAEWPPVAVVASSSPVLLSCDQVGTQASVRCAAAGDVPGEWMSGVGADGHETMHGFTQPPLELATSFQTGKVESAAYTDPALSASSECSDAVSALRECSRTGPLPYLLTSNADRGIVPIVATGAERVLFGEDDDFMDLSTASPSCCIPQPELQTTRAALCAAVDAVAHTPPRPRDVRPSALLASNHDGTGGCESTDCSSHEHFSVHYAATSVSSYTTPSESGLSAAAPVGATGESLDAKLPGDCRPVKEGLTPKVIKNDAGALLAVAKDDQTEGTPCASTAVAGASGSLSALKTPMPSPLRQELFLRLLNDHTVSATHTPAAHTGSSTSSLPNAGILATPTPLHRPHRWRGASATPGCESVALITGFPTPVKLSPIPTKGFSVYPDLAASDAVATADAILTSTPRASVSSSPAVSAIQGEAYECDGDEDDAVTPDAVMDQLVMAKNACAARRQTTSLWASVGGGVSPYSDDNMADYLSCGHSISSISSECSVSQICVGARQTTRVWTPHSSEVSQQQQLTQPPSSCIDGHSSRLLNSFPSSTAVPQQPPPPQPISLYSSTTLGTPSTFPCDHTFSAHLNRSRTALRSERAAEEVSGDSTAISAIFREVQAQPLHQPPQNLSSSDVLTGGLALMHSSTDHSISGRVMPSCVADTLSLGIPTVPTTQSLAQSFGDSCYSPFMPPTTQYIQALTIPGLGWRNCPLAHAAQRAALAVESSEGDTGGTAFICGAHRRGRQETKQPALMSPVFNDNEERKTSPCPTAVPSSVKLPALPLLVTSPVSSNPTQFFDVQQLRFPNLEETQCDAIHDRRAFRSAFLQSHSFHKEPGRLNRSVLPASSCASSISSQLRRSSSSKLSAASPQGFWQPHPGLSSTKDASCNGEVSHAHYHSTFTGTSHSSTYFIDSWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPM0</accession>
    <name>A0A088RPM0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_171110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697802.1">
        <property type="nucleotide sequence ID" value="XM_010699500.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22573854"/>
    <dbReference type="KEGG" id="lpan:LPMP_171110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170017400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_171110"/>
    <dbReference type="eggNOG" id="ENOG502S076">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6344460at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1470.10">
        <property type="entry name" value="Photosystem I PsaD, reaction center subunit II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053233">
        <property type="entry name" value="ABRA-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21715">
        <property type="entry name" value="RH04127P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21715:SF3">
        <property type="entry name" value="WW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="64"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="523"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="888"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1006"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1072"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1168"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="330"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="756"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1282"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="295"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="527"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="893"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1006"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1088"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1173"/>
            <end position="1184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN97149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1326" mass="141966" checksum="A98C55D95BC55A22" modified="2014-11-26" version="1">MNDIPSAGEVFRSDDGTVSTILPSNYGQDYEASEGELEEYAEYIGIDPATEPELMWIAKEGLRAALPDGWRACQTDDNEVYYFNFRSGESLWDHPMDEHYKNQVVSERAKRGSGGGGSSVEVTIGGAPHTGRTAAVTGSTKAIADSFFLRPAAAGSSNRTPGSLTDIGGGGIAAVTTGTTPGKGLSIPGSSMNDGASALRAPPDVSAILALSSTTSHPPPPGASRATANTGLSRMKEREAVLRKRLEEGNEAQLQVLRIELDKKADAERQRLAEARTKLQKDLDAAWEQEGSDTAGGTVAASPAASTATQGRLQIVREVKQIEESWKTRLHDVGTRVRELQQQVEAKQQTLLKTCQQSPEELRKALEACNAAEVAQLLETRKKESDVALAHLKNEQASKLTEAQLRASDAVAAAEKATEAEFQKKVLERRAQNEAMLAALQAAVEAKQADLTVKERATAAALTTTTTNATAAAAAADVSSDADEATIAASQAAADAEVAKAREASAAAVAQLREEYTKKKSEKEVALRAAQQQQQPLSRSLPASSAVSSPTVDLTSPRDDFSARGIGVADQAKLDEEDQKLRDEAYRAARIFEEETQIMVENKKAGRPLTATPSADVSACVSAEAIAALGRTANQEQRAREAENMRHFMAMKQLETKHDQVVRAMKAQLEKNLGSSTSSSASSIFNPRQQPSFTAQLTARKQAWLRDHPAPSAEMPMLPPIPTLPTATLQSGMVAVCMPGEEEQAELVKVRLVEVREEAQQRYDEEAQALQAARERDLETWRDAYRSSRLREVEKTLAELKEAATAESEKQPTELLVPCGTAAAVEAATGEGRRLGRLQSELQVLEDAIASADGEHERQTRALEENIVCLEESLAQLRTLERHEEEARAVQRHLQQQRQLAKGASESSSYAHPDTASASPSRTTLPTSSKLYITEEEAAGEEAVLRARWTALISALRGAVQREMEAYERALNGYCVPHHTSSAVEAAGTHPACFTAATVTTRGGASVHHTVSTPRDGNPATSATSSLPPPAPSSVMMTGSTLPGQPAAVLEQPPLPASSSVAIGSTFTNLSGYTTPLQRPSRNHDDSGTGSMMMSSTASRMPIPPAPQLSLMDGHLGRGGAPAAFSVQRPLLIPSSERQPHHLWPDASAMSSSVASLGARSRYLDPSEGVGVSPAAAPWATAPGGARGGGPPTGTSAASAQQLMAALVGHASYSGGTANGSAIDDAEVARVQHHAARLAALQQTALARRHGLEARRREIDRLRDVWRADMRACKQHGDRAQALQLREVKAALEVQAREFNKEVLKLKKLHARIHREVVHFRRWLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPQ4</accession>
    <name>A0A088RPQ4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_205810</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN98072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698779.1">
        <property type="nucleotide sequence ID" value="XM_010700477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPQ4"/>
    <dbReference type="GeneID" id="22574793"/>
    <dbReference type="KEGG" id="lpan:LPMP_205810"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200065400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_205810"/>
    <dbReference type="eggNOG" id="KOG2187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250660at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030391">
        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045850">
        <property type="entry name" value="TRM2_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45904">
        <property type="entry name" value="TRNA (URACIL-5-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45904:SF2">
        <property type="entry name" value="TRNA (URACIL-5-)-METHYLTRANSFERASE HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="580"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="587"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="511"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="381"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN98072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="604" mass="65706" checksum="21CBA81D0BDF84BD" modified="2014-11-26" version="1">MPISPPPPSTETHDAVQLHEHSNANLLKIDTHDKYSTVGAIKKLIAKTLPAEQREIQEQPLLKGLLRINKNPKNPYLFMAFKTPEDRAVASTLLQTISHRGRPWMEASVSSRDLELTHKGGVKRLRDGNNGNGGSKLAQYEHLSMEEQLDRKKRHCLSVMRAILPSHGYGYASFQDRFLGIFTSPLREGYRNHVNLSFGLCADGTTSALGFQEGSLVEGTAAILPATLPGKDIVTMNTVAKVVAAALMNVCAEFRNAAKGGLDVFDKVKASGFWRKLQVRHNVKGEVMMDVEVDAASTTAEVWAAVRRRLVEVFTSDEMRVKLVVAAGLSTAAVVSLQCHTHTGISSLPFDVPREVLFGTPTLTEYLAGLCFELSPTAFFQVNTPGMETMLTKVTEVAELSTGTTLLDLCSGTGTIGLTLSKHVRRVIGIELVESAVANARRNAQQNGIANAEFHCGRVEHLLPSVISGLPAEDRGDIVVILDPPRAGVNSTVLKWIRGMETIRRVVYISCEQKALERDCPRLTKPNTKAYRGNPFEVTAAFAVDLFPHTHHVEMIAVLTRRPESTGAPLSVSVPALVPAPTSAESSAEDEEEAAIDVDNGCVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPZ4</accession>
    <name>A0A088RPZ4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_204260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698627.1">
        <property type="nucleotide sequence ID" value="XM_010700325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPZ4"/>
    <dbReference type="GeneID" id="22574637"/>
    <dbReference type="KEGG" id="lpan:LPMP_204260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200048700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_204260"/>
    <dbReference type="eggNOG" id="ENOG502SJTV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="262658at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="202" mass="23863" checksum="3D5E388C7BEE5061" modified="2014-11-26" version="1">MPRQRWNNSGRCESDNSYADPLQQLLARNLQRKGAAAVLSKRRVSQLARPSCISPVAREARRRSELMRSAQELMDLERYERRQLMEVARNRFHVMTCAFFGAAVRNMIACELSERKALFREWQQAQRDMGALIDREFSKLTLMTPHKFKAVCRLIRSETVMRRRLQVTEAQDRDLYAHFMYLEQLKALGSDLNEYRRRIALH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQC5</accession>
    <name>A0A088RQC5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_220170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699019.1">
        <property type="nucleotide sequence ID" value="XM_010700717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQC5"/>
    <dbReference type="GeneID" id="22575063"/>
    <dbReference type="KEGG" id="lpan:LPMP_220170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220006900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_220170"/>
    <dbReference type="eggNOG" id="ENOG502RYT9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273348at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="504"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1112" mass="123484" checksum="EDB5E12FA648A63A" modified="2014-11-26" version="1">MTDDSYSYTGSYTGEYSYTYSYSDGTGSYTGSAAEKSLHPELAGAPRANVIQDKKAPSPSKPGAAKNADSADSYSYSDAPSSHAKATPAMGNREKSVKWQTNANEGDDRSYSYSYTDDDNEGSYSYSYSDSQTGTATPPMLRTPKVVVVGAGQQSTKPAAKRANRIAAATPPAVTSTAVAVTNAASAETYSYSYSDEDDNTYSYSYNSYSDSYYYSDDSYYYSNSSSYASDSYYYSDGSSYYYDGSSYYSDDSYYYSDTYSYTGDSSYYYSYSSSTASGERRGRRGKPVAHMASGSSDYYYSSSYSGEYTDNSDSYYYGSSYTGEDSYYDYSYSSYSYSLYAYSATGESSPSTTSYAYGSFAEFLLSECAEAGKRELVVLRAPAKDVPHPPEAPKRCFVVFKSTEDVVWRFLQRLMALQRLYEAWREVVGSRAAAAGTAEVEREETSTPFTPTKEGCFSERSMRIAFRVLRLNHLERQEALRNAPVPLPMEAMEDIFNTCVVARAKERVAQAFLAHDTYRSGEMSLTQLSALLQRLGLGTSPIIEGHRISIGLSTEGTLEMIVKVGRVVQSNASATSASAKPQQPIQWEVTPVYVLRIIRQSAADKESASVHWRNKTIYMGRHLVLRGVATKALFQRLKTYIEAAAYLCVLAKVFSIEDTERGTPLVQYPQFIRGVLLANPPADILGDAAAPPRKLLYIENLFRVVFHPLEMLQGYMDGSPVPRYNRHWAVESTLYSTNDTEEKRRRNVVPGIGLDMHVLPTPSVRPTDEVRLSFAVEKVRVPARPPRYARCFCLVSVVTPAKVFLPAIEVPVRHIVPSAAKDGYYTWRFHDKKHKRQEVVLQFAGSAVDSIYVECCYETYDACPPESPEEAAANAEVAATSRATSNTTTVWCAGYAVFAVYGAMTAVLPIKAGSLLHGQPRDSTFVSDAPAWTAAAMRLTTESGCCTCNLDRYSQYKNATENAHQIKVKVLTPKTTIPGAYRMPVRYIAYRRHVPMISQLRTAVELMGRETSHVRQTFRQQAVRYIFSVVSDPGLLDQLCALWKYRVRHWTKAERNNEGHKHRTLLACVAALYGLKNSCAGSKEVFAKSLVKGKPLYMIIDSAAPMVPVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQJ4</accession>
    <name>A0A088RQJ4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mu-adaptin 1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_221040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699104.1">
        <property type="nucleotide sequence ID" value="XM_010700802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQJ4"/>
    <dbReference type="GeneID" id="22575150"/>
    <dbReference type="KEGG" id="lpan:LPMP_221040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220013800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_221040"/>
    <dbReference type="eggNOG" id="KOG0937">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09250">
        <property type="entry name" value="AP-1_Mu1_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000002">
        <property type="entry name" value="AP-2 complex subunit mu, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="6">
        <location>
            <begin position="177"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN98397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="433" mass="49194" checksum="F6D2C51F473A495B" modified="2014-11-26" version="1">MASVLYILDSKGSPLIYRSYRGDISQDVPSVFQHRVIDEEEGRVTPVFEEEGHTYTFVRENDVYLLMVSNINSCPLQQVAFLYRCVSVFKAYFKTVTQETVRDNFVIIYELLDEMCDFGFPQFTEEKALREYILQSTFLTKIMGSKTTLAQSELPTAVTGAAVSTPWRLPRNYKYSNNQVFLDVIEQVDLLANQAGETLSSEIVGTVKMQCHLSGMPTCTVGVNDKILFDRTGRSGSTVEMEDITFHQCVKLNQFESERVISFVPPDGDFTLLSYRLNERIQQPVKLRCIFTHHGTTRVKVHCTLQTKYRTSLTANEMEVHIPIPSDADCPQAESQTGHLQYAPQVNALVWNLGKIGGNRQCSCNAEFHLPSVRSSDMNDLSKMPVKVRFVIPYFAASGFQVRYVKVAEKSNYVTTPWVRYVTQSGVYEVRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQN9</accession>
    <name>A0A088RQN9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA uridylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_212060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>RNA(n) + UTP = RNA(n)-3'-uridine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14785"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17348"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173116"/>
            <dbReference type="EC" id="2.7.7.52"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.7.52" evidence="1"/>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698990.1">
        <property type="nucleotide sequence ID" value="XM_010700688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQN9"/>
    <dbReference type="GeneID" id="22575028"/>
    <dbReference type="KEGG" id="lpan:LPMP_212060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_212060"/>
    <dbReference type="eggNOG" id="KOG2277">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="407432at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050265">
        <property type="term" value="F:RNA uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000039">
        <property type="entry name" value="RNA polymerase II, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF40">
        <property type="entry name" value="POLY(A) RNA POLYMERASE GLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="3">
        <location>
            <begin position="72"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00049105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN98283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="378" mass="42998" checksum="DBCDA7116D10DD9F" modified="2014-11-26" version="1">MCFFMLIPTHSRTNAILDINMSPTIAELSGRILSQQRYSQILEQGKWLLGLLKGVSFDIGAKEGMRCVSPVVLPYGSIVSGTSLRDGDADYIVSFPLALESTCQSIACVIERERQEKLLSDIFVHIRKNNRDDELYPQRIFRARVPIVQYVRKSACEISKFDICLSLGGLKNSLLLRQYMAGDPRLRLGVLGAKQWGRDHQILNTRRGWISPYALSIMYIHFMKSTGRTTFAFDEEAVSQRVNEIISTAAESEGDISQVDELASVLPLQDADISLVQKDVFDFFAFYSTPGGFDFDASVVDIRSRERFSSKDQWCESLHELDEKERWQLLGHEVILLRDPFEPHSLGRSVDFFRGEEIREKFRSASVKKEPLSFFASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQR3</accession>
    <name>A0A088RQR3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_210950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698882.1">
        <property type="nucleotide sequence ID" value="XM_010700580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQR3"/>
    <dbReference type="GeneID" id="22574917"/>
    <dbReference type="KEGG" id="lpan:LPMP_210950"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210013500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_210950"/>
    <dbReference type="eggNOG" id="ENOG502S068">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264817at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="291"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="46898" checksum="771A0829D3906CAA" modified="2014-11-26" version="1">MRLYDVVKGKKKRGRCPHIHTLDAPVARTHTYLSCVLLSHLIPQECATRRDLLEPGHHSLFMISPCGSTETRRRTAARAVQRKACQIMIRLSLRHLAASTGGFSSAAFIGDDGGTYNRLKNEQERLMHDHQQERAEVQEQQYHHRRGGAQDAETSASASMSSSSSWEETCSPTGFHGTKGSSSSGTTSHGTAAEEPLERPTIDTYRAMTDSELIETLRTRDAQIHHLRAIYETFHYEADRHLRKMIFDYHDKTMQLSQVHGRMQQASLEINRAALSKMRDQQDMMTRDKRIIFTICTLWTLIFWVWVRRHYVKRRELEREPLEGREWAQMSPSITGAGSYNDNFFGSNKRNARFRETAWERELRERREAQDLREQQRTLLQNQTELQKAVAAQRAQQQEDRRSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRX4</accession>
    <name>A0A088RRX4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome c oxidase assembly factor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_205020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCO1/2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97994.1"/>
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    <dbReference type="eggNOG" id="KOG2792">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome 20"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Cytochrome c oxidase assembly factor-like protein"/>
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        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SCO1/SenC"/>
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        <property type="entry name" value="C OXIDASE ASSEMBLY FACTOR, PUTATIVE ELECTRON TRANSPORT PROTEIN SCO1_2, PUTATIVE-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151">
        <property type="entry name" value="ELECTRON TRANSPORT PROTIN SCO1/SENC FAMILY MEMBER"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="67"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:23378"/>
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        <location>
            <position position="71"/>
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        <ligand>
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        <location>
            <position position="182"/>
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        <ligand>
            <name>Cu cation</name>
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            <begin position="67"/>
            <end position="71"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
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    <evidence type="ECO:0000256" key="2">
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR603782-2"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN97994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="231" mass="26604" checksum="63E83E0BA0868654" modified="2014-11-26" version="1">MNWYENRKLEKLELAPDFQSMQSVSLKPKTQLGGPFRLRESRTGKYITNDKLFQDKWTLLYFGFSKCAEICPSTLKFISEVMRVCDAKYGPDSELAAEERKLQAVFLSIDFIRDNPEVVEQLVRKYDPRVRGLCGTREEVDAAARAWRVYYSSVDETSEERDAREAAGVAVPEIDDTYQLDHSSAIYLVGPDGKMKDFFFKEMGVEDIVSRVGIHYSDIYGFSDTRQTPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RS16</accession>
    <name>A0A088RS16_LEIPA</name>
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        <submittedName>
            <fullName evidence="3">Ppg3-related protein-like protein, putative</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">LPMP_240360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AIN98670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_010701075.1"/>
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    </dbReference>
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        <property type="component" value="Chromosome 24"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
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    </feature>
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            <begin position="504"/>
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        </location>
    </feature>
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        <location>
            <begin position="598"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="678"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="787"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="429"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="530"/>
            <end position="543"/>
        </location>
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        <location>
            <begin position="556"/>
            <end position="567"/>
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    </feature>
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        <location>
            <begin position="598"/>
            <end position="610"/>
        </location>
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        <location>
            <begin position="638"/>
            <end position="647"/>
        </location>
    </feature>
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        <location>
            <begin position="732"/>
            <end position="743"/>
        </location>
    </feature>
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        <location>
            <begin position="757"/>
            <end position="768"/>
        </location>
    </feature>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AIN98670.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="808" mass="86432" checksum="2D7C8F3A371B19D2" modified="2014-11-26" version="1">MNRSALPSGGTDVTEAINTAELEAERYIARLEEEVQTLMREVSDKDRYIIAMSAVKDSMSLELREQKKRGELMENESSTRQMLSYSFMSMLRFYTTQAESRRAMQLETQISGLKYELKLAEAMLAQSQSSATAAASQQHQQLLKWQNEEDELARSVSATLRPLLQGEYDRLAQLVSEMPSKVRMMMCTGYSAPQSEEDEAARGAAVPPQQQQRLHEMLESLLASRGGVTGALVDAASSAPCAPTGIPSPLPLALSGVDPSHFVHLVSRVCHHHEVMADLYCAEVDQRMAFAQYEGDIIRFISAKQIALTWAALYHEKKDEVKHLNEKIMSLRGELRAAARLSRGVVVSGPNAGSNNITQSYEAYAAPYVPSAARLTNSSRDKLKRPSTSTQMKPQSVVAIRRPIGELREEARRLGVLPASHYPPLVTGPSPSMTSSASSSPSDLTQTLPGKDQKNAASRKRGGAAEAAVVPALVEVPTVAKGSNIACNSTVPVIRALPCQCESEGTSPSSALSHRASLARRHTAPRSVAQPKSRTCDSSQRFETTGEHSIPRPVLSDSSSSSSSTSDVLAAGRSQVKKAALGHGFALAAAATSRLASSSSASSGSSLSHAKAQEVAAKPTSGRTKQQPKPKVVHNSFDDADDDENEAEAAKVRKDTVQAFHRLPSSKLAATATFNNKSKARNAKVDSEADTSFDSLGTPAKRSKKATSAAAKWSHMRKSSFDEDDSNGDIANDSSSSLGSTADTPGPASRAVVGSNTVRRTTAATQSSATRLLVSATTTTTTSAAVAFGKARSTPSTAKQTRLKLPTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RS31</accession>
    <name>A0A088RS31_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="10" type="ORF">LPMP_241350</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AIN98768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_010701173.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="lpan:LPMP_241350"/>
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    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_241350"/>
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    </dbReference>
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        <property type="component" value="Chromosome 24"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd16544">
        <property type="entry name" value="RING-HC_RNF138"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
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    </dbReference>
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        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
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        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
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        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040365">
        <property type="entry name" value="EFHD1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13025">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13025:SF6">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="16"/>
            <end position="51"/>
        </location>
    </feature>
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        </location>
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            <begin position="281"/>
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        </location>
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        </location>
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            <begin position="95"/>
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    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN98768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="395" mass="44035" checksum="0BD7F7B8BB96BA4A" modified="2014-11-26" version="1">MAALCVGEDFCEEFTCAVCLDSWKDPIELTPCGHIFCKACAQDLKECPVCRKKIDLMKTPNRTLVNMAKQIRVKCMRCEWKGTREQGMSHVCGNASASLPSQPSRPSSVTTQPPQQHPTAANFPSPYTQQLPYSGYGSPPLQTLQQGQINSSLWQSGAPTQPPQQSAGYSSSHANAYPGAAPSLGSGNAGGQGGYPSSNNYWSQTEVSYTGYNKQPPPSRSPQTRYQVIEPTGPRPWTLYGLDQAEYDQIVSLFVFFDDDDSGMLDRNEVGRLARWLNFANTPQGVKQIFDDMDFDHSGRLSLGEFLTWLRHNKPNPKTLYGLTQSQYNTIMMQFRMYDTNQDGCLEMGEFTRLVQNLGDVRDTATAQRLFQMIDRDRDGAISLHEFLIFRAGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSJ9</accession>
    <name>A0A088RSJ9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_250200</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the peptidase C12 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699592.1">
        <property type="nucleotide sequence ID" value="XM_010701290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSJ9"/>
    <dbReference type="GeneID" id="22575668"/>
    <dbReference type="KEGG" id="lpan:LPMP_250200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250007100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_250200"/>
    <dbReference type="eggNOG" id="KOG1415">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="427186at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.532.10:FF:000006">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF17">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="9">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="7">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN98885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="233" mass="25300" checksum="01BF2D4955120067" modified="2014-11-26" version="1">MWFPLESNPAVMNRYLSALGITEAKLQFVDVYGMSDDLLEMVPSPVHAVLLVYPTCEATEKRIAEQQAAQAEEIAALCRLHRVFFTQQCVPNACGTIAIMHALLNNHDKLGEIARGSILDSAWVKAAEVTVDPKVMGKLIAEDKRLAIAHAAAAQEGATTNQGIDANINLHFVCFIQVGGRCVELDGRKDHPTLHGDCADNMSFLKAAAAAIQERMALNPNAYEFGITALVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSL9</accession>
    <name>A0A088RSL9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_250400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699612.1">
        <property type="nucleotide sequence ID" value="XM_010701310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSL9"/>
    <dbReference type="GeneID" id="22575688"/>
    <dbReference type="KEGG" id="lpan:LPMP_250400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_050010500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_250400"/>
    <dbReference type="eggNOG" id="ENOG502SHW4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10265275at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF5">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0736">Signalosome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="243" mass="26552" checksum="A9928BC35841DE40" modified="2014-11-26" version="1">MNDSFYSSAHTLSLLSPSPLPLWRQSAPPDRFFRLFLFPLVRMGVLGGASYVAEVQQAATAADALAAVQSGLADTSVFFYGALLSALEAYMGKQDVATVPADTSDTIALLKLLAFNTVSDVAAASESVKALLSQHPCLMKKLQLLSFLTLCSQHPLTPDGVCLSYGDVERALGVHDTVSVQCAVLHAVQQRLCVARLNERERQMRVYSYESRNVTPYDIAELKERVAQWTAYAEAHLRDIQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSV7</accession>
    <name>A0A088RSV7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_251950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699765.1">
        <property type="nucleotide sequence ID" value="XM_010701463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSV7"/>
    <dbReference type="GeneID" id="22575843"/>
    <dbReference type="KEGG" id="lpan:LPMP_251950"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250021600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_251950"/>
    <dbReference type="eggNOG" id="ENOG502SI0H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="262775at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="427" mass="46616" checksum="4F113825AFF16351" modified="2014-11-26" version="1">MPPFPSHPSLAFSPHLPHSPPLIIMMLLVNIKLTSHHTHLEAHSACARLSLMDTRRSAAAAPSLILIDMGAPLQECLRRLHAQTVRVAATLAAEQQDTLLSGMKMPSVATLLSEYRTVASDTLNCSGNHTAQLRRRIALKLQRLRKEQHIDLCSPTAFADEIHSLVAALPAMPAKGKARSEALGDYAVAPTRAPLLPPPSGDVLVTQREDEDDDIFGWVTQHLSESPHPATAPAECTASPPRATTAAAVDTTAVTAHEAQNDEGAAESLLRRIACDLADVVECKGRYAATVEGVHQQLMTLRRYAESLLIVCEGDGRSMPDSLGARMRHLLAYQPSHTVSSEAEQQVWQRAWKEVGCNTAPALEVGTPVETIDVAVLARANIQRYEALQRRWLAVRQAYETHLVQLNQQMALAALQLDEMEAMRKSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSZ6</accession>
    <name>A0A088RSZ6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_261240</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699944.1">
        <property type="nucleotide sequence ID" value="XM_010701642.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22576027"/>
    <dbReference type="KEGG" id="lpan:LPMP_261240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260017300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_261240"/>
    <dbReference type="eggNOG" id="ENOG502R26U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267758at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000285">
        <property type="term" value="F:1-phosphatidylinositol-3-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748:SF7">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="10"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="89"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="288"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="497"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="555"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="648"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="692"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1159"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1218"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1456"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="181"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="314"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="507"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="655"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1172"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1473"/>
            <end position="1486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN99237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1531" mass="159152" checksum="E1FF41BDABAA7A57" modified="2014-11-26" version="1">MLHPRLWRDDHLTAQCTACAAVFTLFHRRRHHCRHCGGVFCAACTTKRLWLRPGPPVFSRHVESNSAKRVLAEMLATPGVVTPITAVATPFSNPTSSLRDANSSASGTSKNEARRSVATMTVTSHHRDSNSERYTSSSAEAERPASPPKSPSRPRSEGSGLVASRSYHLVSAKSIAAASAVGQTSQTPSQSSSHTPEAQSVYPSHWMPSRLFSSSIDVIAPFTTTGDASSQAWTKSKVMGTFEQGSSSHLLRGSSVTVGGEESGCTLLMSDSLLNQCCLSEHQNDQQQNQQGVAAGDGSALDSSPETRNDERTTPGTASATTRGNGSNRGDSTKGILVGEENAYRRKSYKVEVDSVQCITWYLCRVCCSCYDHLVNCIIDAHEAPAIALHSCSRLPLSCYVRLCSSGEPLSTDGRTGNSHQWRVSGTPPRATSCPTPAGSVALASWLSIWTRVRASVSLLASCAQSTMALPAMTAAATSPPSSSLHSQTHDLCQARGAANSQVSGKTNSTATAAQTSAGFSGSGCISPVSLESSRGDDSILSLSAQPGIASLNMASAQPQSPQLQQRQQSSSSRRARRVVTPPRRLLISIDGSPGPLRQAVALARRRRRIAVILIDERDLAAADDGTKVQQQQQYHEAPCGALSALLSAGPDTETAPQPSAITEQSGSMRSADWMPSIATAAEATSLVFQHTESNKDDAHQQNRVAGDTTAPVTTTKASAQRPKLSILVDDVTFSDADGTTAVSTSCSSADTTALRGLAPAAWLLPQLPLQAVAPVNLMTATRAPSATLFSLLPYEHASLGAAVSSSVGAAATTACPAISRPISCVPEGSQAVVFPIHSTGAATTPKMEGKLRALPVTLDSGMCVLRALFSQIGAVVRLSSTLATTACATTTPTSAAPAASGGSGFPLLANTTGAGSLFADPANCGSARAIAMPLWSAGPESYAAQRQALVRDMIMRYQLGPGVAPSEVVTSPLISAFISNAYTPAADQNDPAHWCGTTGHRGAPGGFGTGSSGYVNATCRRVCGCPTTASYERVTAPVTTYLHLRPPAAAVTILPVSTQVEVVGIPIDTSAVTDTAATTAVTPSAVPAVSPGHASPHARGGDVCASSTVIPGLVAGDTGGSTSRPFTMTELLPQLAKLSTNLDGYVIVILRRQSSRYASGDDRTSLGGGTTATRPGSNGNSAGHTSVAQMGGSNCSGVQQSADADRLASSPCVSFSLPEESKCSVPRSPQRHDPNQRQRRRHRVTELFGGQHIRLLYQQLQSCGVPQPAISVLEVSNEAELDALKLSPVHLPSGKSPLEEAILYRDELGTSSMPHLKDRAATGGEDGVAEGWPGAAKMSSQNSALSASGMSTASSVDSGSMWRPSSILMSTSAPSTQVTERTPYSPSILGDSLERMQLPASVSGGFGRTARLMTTSTVSVAPPTALEQAMASLRCATRQLGVSMCSMTYTSATTPRTMGSAPPLGSSQSPWAATATTVEEASEPALLDSPRLRASHNAGGSGGDGALLTRPLESLVATLVYRDICRTLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RT00</accession>
    <name>A0A088RT00_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_220810</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699081.1">
        <property type="nucleotide sequence ID" value="XM_010700779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RT00"/>
    <dbReference type="GeneID" id="22575127"/>
    <dbReference type="KEGG" id="lpan:LPMP_220810"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000030600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_220810"/>
    <dbReference type="eggNOG" id="KOG2808">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261918at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071021">
        <property type="term" value="C:U2-type post-spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004098">
        <property type="entry name" value="Prp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039979">
        <property type="entry name" value="PRPF18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007:SF19">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02840">
        <property type="entry name" value="Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47938">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Prp18" evidence="9">
        <location>
            <begin position="436"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="143"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN98374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="545" mass="58837" checksum="9FA022DB43313C81" modified="2014-11-26" version="1">MNFEGLQGLLKKKQKQRQQPHGTSDEPSAAAGVSGNPPAHTPGLAERVAAAPKSATNATGRHAAASSSIAGTVSATSDPYVVALQSVRTLQQQQQGALSRTTAGPKRSREDMEQESKLVGLVNTSTGLSCADPSDELNVRSGASVSTPPSASLSTSAQPLMKSGEDVLAQREMGVAVLQTCLTQLEHYWVAEQASNKTLASTGHSVTTTALASAVSQPQHQSPSASALLEPSVSLTVSSSPFPIPRALRDYILAQFVTPNPTVRRATGLPEMTVLDREFELLAQIKAEVEAGPRKDVVDSKNKVDAKVGGVPEAQQQLAELLPALWYLVALLWQHSLDPHQRNGRCCLTSTAMPREGLLAPSQQGWSPVVYFALQNALPADAQLLQGRAIAEEVDKWRALARTRQNALELLSYVCSDHETSAAASSPSTAAADLIIPPDLRKNLHTMVVRHLRQERNFMAVRQDYVDITMGTANWKLGLFSGGEVHMRRSMERVERNRIAHLLNNEHATHLLQAVRELIIFVERHSPAKCSPFFYPAHVTSIMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTE5</accession>
    <name>A0A088RTE5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_260260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699847.1">
        <property type="nucleotide sequence ID" value="XM_010701545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTE5"/>
    <dbReference type="GeneID" id="22575929"/>
    <dbReference type="KEGG" id="lpan:LPMP_260260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260007400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_260260"/>
    <dbReference type="eggNOG" id="ENOG502RVMZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271607at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="610" mass="68877" checksum="3F53FD9C45268E89" modified="2014-11-26" version="1">MHEIHGACLALVKAAPEARPAMLDSLASSVEVIWTVARRHLTEEERAQSATRFKMYTEAFLAMLQGCVRGAADGGTAVLCRSLQRLLEEQGFPEAEFGPLASYLGEVLLEEDVQGYSYSERTSLVMPMPARYEGDKRSVEEGSCKRAGFEVVLPRFHPHTEVNTVIQLSEPKKRKPALDEYRIFSLPKKAATFAADDFMVDDELLHRAYVVLTTHLDAYGSLKGLSPYARLLLWNLLDRNDVLFSTLYDQRVTSESMRQQLLRLRELLAVHKQALEETRAAARQMASLVGWYAASAQWRDQALSKLDEVEEFDWYLLADVYRSGGRAIFPNYARSNAVVHLALGVVRKLDKIHGHELDGAPPMYTVVSKLLLPLLMGEAPELGQYCFGHGAFDADSSHWQRQRRKLKTRMDELAKTVTSSAPQASPSSHSSVCTYLCASLIFPLQCLGELLELCSLVMFSLMGVDAFTRSFLATNWEEEDDILAYLLRREPANPSLVPLVGIPRIYKDMVTSVQLLMADKMVPYVVEARRLAGEHARVSLRHKSYPYWRALCTMFIEEDRFDDLSALQVRAKEDPTCLYTAAGFEVTPKVWLEDLVELREEEERCRCGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTZ5</accession>
    <name>A0A088RTZ5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Myo-inositol/proton symporter (MIT)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_240650</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699406.1">
        <property type="nucleotide sequence ID" value="XM_010701104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTZ5"/>
    <dbReference type="GeneID" id="22575474"/>
    <dbReference type="KEGG" id="lpan:LPMP_240650"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240012400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_240650"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17360">
        <property type="entry name" value="MFS_HMIT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF12">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="402"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="5"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="502"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="518"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN98699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="545" mass="58780" checksum="74494330387D3F36" modified="2014-11-26" version="1">MRASVMLCAALGGFLFGYDTSVINAALFQMKDRFGFGEHSWQYALIVAIAIAGAFVGAFISGFVSASFGRRPCIAVADFLFIVGSVLMAAAPNVEVVLVSRVIVGLAIGISSATIPVYLAEVTSPQHRGATIVLNNLFLTGGQFISASFTAIMVIFTSNNVGWRVAIGIGALPAAVQMFCLLFFLPESPRWLLSKGYSDRAKAVAAEFDVDLCEFQEGDVVPSVSIDYRPLMARDMRFRVVLSSMLQIIQQFSGINTIMYYSSVILYDAGFRDAIMPVVLSIPLAFMNALFTGVGIFTVDRFGRRRMLLISILGCLALLVMIAIIGYFLGTRIPYSVGGWLFLALLAVFLGFYAPGIGCIPWVIMGEIFPTHLRTSAASVATMANWGANALVSQVFPLLLGAIGVGGTFTIIAGLVALGCLFVYFFVVETKGLTLEQIDNMFRKRAGMPARYHEEGESGTRDDKGGEFGRMVTEDAGDLSSLCNQSVEPAKAVVDAFMPAVMSDRPGTSNEDKEVAKASSSEPQSFANQNEEQQTAATKVLRERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RU25</accession>
    <name>A0A088RU25_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_271430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700230.1">
        <property type="nucleotide sequence ID" value="XM_010701928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RU25"/>
    <dbReference type="GeneID" id="22576321"/>
    <dbReference type="KEGG" id="lpan:LPMP_271430"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270021300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_271430"/>
    <dbReference type="eggNOG" id="ENOG502S0QS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="261244at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="378" mass="41880" checksum="1914F1852C910393" modified="2014-11-26" version="1">MEEWIKASLKDKYISKVDASSVQSGVFCEVFTSPWYDDGVVFDWTALHQRLTQPTAALSYMTKAVTALRRFGAEQLMAASGGGDNKCFSTVVELKSPWTLQPLTDQAQRLSVFDVLLSTTSSTLTPVPPTSTSHSPAPSSSNVRQLYTFLRGPPGQRSVRDDIMRVLSSVEEQFRKSGVHVVLFLSSFVLFGSDFTDMLHGTAAVFRALTEAGFSIDDHGSCFTPRIVKPLCVYGEDWWTTSPLQSVQSEEEVAALLIALFYQWLQDAYVWSCTAPIRLFPDDIETRANKAVRLFERFVRGLVLPRAPATRLDALHASLPEEGGKLLVLAAVGLEKKQTPTGLQRWSVLELRLVLAQLGAYEHIPSEYLGHSVNNASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUY7</accession>
    <name>A0A088RUY7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_280510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700392.1">
        <property type="nucleotide sequence ID" value="XM_010702090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUY7"/>
    <dbReference type="GeneID" id="22576496"/>
    <dbReference type="KEGG" id="lpan:LPMP_280510"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280010500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_280510"/>
    <dbReference type="eggNOG" id="KOG0548">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2335338at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="212"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN99685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="713" mass="79441" checksum="1EE0105183F78FE0" modified="2014-11-26" version="1">MHMSLGVADATAEGNLFSLCPEDDGNVPDMPFFAASNLEDRPIAPAAEDYPLGCEVELRDIEFAKIAQESSHWEPIMEAVFAVPRRRVRVDRHTGDYTFVLCNDIDGFERVGCTLYRACLSEPKVKATRYYSSIRSALSGLELEDNAEDILSRPVQLCVATATAAETGCTVLEARGAATPSAGNNNILTSVKSVRSAVYMTSSADDARRRSFMTYMRRGTAEIGKRNCEAALRYYNRALEEMPEEEARVRSSRSVAYLLAGEKDRALEDANRVVHLVPRESVGYIRTGNVLRSMKKFVDAQKMYATALKYDSSSTVVRILLEGNSVAMLYEGRTKRYKKMRIFYDDAAQRAIAVAAQNMDASEIVMKEASSCVFPLLSGIYRVASGRQCCPMCCHCGRPFVDEAQMAEQIPGLTKQLLNSLHVVVRPVPCDSSCNALYCSESCKSKAWVEHHWVECTQRGRWRDGVPVVHCLLDQYVMTCAANAADEEVPTDISPTPQCVAEDTRPIITAACVRIAVRMMSRMVSSVLPAQEAVQQYRWLPVADVVRSQRREVKELLITCYSTLSQGFSSEDSDQLTFEVFQDYYEKAKSNSIIICCSMWPKVVERVRSHLDLVTAEDSPAGLQDSDTPFHLCLQQVLNAPRQGVPGTYHICISMFELASLMTSNNCTRSETMRPNVMVRTFAESAASLRLRTLRPIAKEEVLTMDWPVYGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVQ8</accession>
    <name>A0A088RVQ8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="2">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_291500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="2"/>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700756.1">
        <property type="nucleotide sequence ID" value="XM_010702454.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22576913"/>
    <dbReference type="KEGG" id="lpan:LPMP_291500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290019100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_291500"/>
    <dbReference type="eggNOG" id="KOG0902">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264149at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05167">
        <property type="entry name" value="PI4Kc_III_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000012">
        <property type="entry name" value="Phosphatidylinositol 4-kinase alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000056">
        <property type="entry name" value="Phosphatidylinositol 4-kinase alpha, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF15">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIK helical" evidence="6">
        <location>
            <begin position="1722"/>
            <end position="1904"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="5">
        <location>
            <begin position="2013"/>
            <end position="2294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO00099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2310" mass="255315" checksum="82BE46539791D3D5" modified="2014-11-26" version="1">MGGGGGGAGARTPSQAPLAREKNWGLVGFGHRALEATLVRCIPESIDECVHDAVALGVLRGISLTYSQQLVYLGPELVTHMHDLTDAFATSDHRRELPYKRVLSILLEAIRCSRVIDYKRTNNWITAIIQERYVVRGLFQREKLHAHVVTATLAMLIRQYQEVARECASKVVDLGSMPDFTEGDQLIELLWKALQDTIGSWEDAASAAERHHLTLFRHNIHTLVHHLLQAEVERLRCYYIITSTTAAYQESLVVMSVGTNMSRRQSSPPLAMLQLEAEQQGADRCRRDTLGGQDGNARRDSDASAVAPYIPSAEEESLRISICGNIMKFLLLPTSIMSALPRTEEANELRASLTEAAARVLSVVTARVFSSCDDTSVTTTESSRPTAPAAPCPISPISAAAATPRVQYTDCIPAITDLLALPLRRAHFSNNFYRCIEELVYKLIQTILQANVAEDVAATINQSSLGGVANVHEPTPPTSNTSSDAILSGMAAVVCMQYMCSTNQRIRSFAISEVMDAVVRLSARRRAEDTEMAVHRSLARKDHSDAAPQGVVDAADPKEAKRLARHLRARRLELCFEALSSILVPTIFDVENYNREAEAREVKYNRIRNGAAANDRGESKRKELSRYGQLLCDTYVDSLRERLLGIEEGSATHHHLVTPVMAVAAKAFLYLVLRVHERLRRISGMALALVQAAETGVEEPGKETHRPAAAMARDRRRLLHAFNAERMTVVLLLRGVIQNMLSVAWPSSGVLYQNPTSGCERPLDIATTPAVMAPIAFAVLSPFLQPLTMLLHLSTLFPARSLKQLCSHHQYARYLTLEDPIMSDQYVFHYYRRPSCVHVAAKAGGSGGAGTSSLEEQMELECWALFRSCWMMFSYYKYTAEALLAVHDGGIAPLENTNPAAAATGLNRAPILSTKQCKLLRLIAASAAPLLRMCSSDVQQAMADIAVLLRHTLACVLRFPVAATDVTAKSGIVHALLRKSLRRLCGGSKGCWKRLNTGELMLLQCVAELEILRAAAGSVAQLTFYRHFEVREFVASATIPMALGHIINTACDHYIQAVRSMLPGVAFQVTRTDLMQLVFLLIFAIGSVRESASELVVRVVRSFPTYAAYASSLPLLWCVLDLLEAGTAWQIEALCEHVQFVWAPAVAADPHSTERQQHVLFVADVAERWAAILREKAPIALFETAIKFMVVQQQECGEQAATQPGRRHAGSRLAVLSSQYGLEESSPKLDDGAITVMRGAEAAGHVVAAEYAQTLLLHGRAQGTMQVASWYTSAGQMQGTVLAQLLATTHLSRCALATAVAQRLQSSLLRPLRALFVETGYSVDTVLAPETSTIGDEDAVALSEVDATPLLRGAPDRAETAASFAAAVALLVTGNGTLSGRRQLLQSMVQGAVRTFRSDVLYDAILCWKWLLCQCRETYLLPMLQELDTALVWTATNRLGLFDGHCSSMNRMVQSGEVPILHGTASSSGQRRIGMPEEAAVYVADKVYTASPHKLLLSFLTDMYVEEGNPLCLSPEVLRQLYLVAAHIMQFAAVLSLRDGMFGETMRCLLVVGSVAQLLREANVRRLSAGLGTIVPFAAIGALRQRWYMALLRWFTKTPPSWYYAKDPVPAREEAKVVSSLSQLVKEEGDLLARTTLGFLDFNSGVHRERNKSVVHHWESLSGVHERIAAVRQAADGGEAGLQMTIAQEKQRLQGLLKLLRVLVEHEVLRLNVWRTPRRTLKIPNTTPSSGWGKLIECADHHSPAVVVAMVYRFSSIPAVRAAASLHVVAHPERYSNLAEAVDLYLTEDVLRAGAPRLFLFRACTIIQALGLLDPRYTAYKSVMSYAIHSLLSQRSERLIFYLPQLLQLLATDTSGSIEAFLLRTSAKSTMFAHQLLWSLQTEGEGSGALAKKCQQLEKRVKAAFTPNEEAFYKSEFFFVGLVTSLSGEMMKFDKPERKAMLRLRLKDDIFHALPKTQHLYLPTDSNYRITDVITHTAGAMQSAAKCPILVQFTCVPRATEDMRTPDELALAAADEQEHAAGNNYGNTVAHPVVKACIFKMGDDCRQDQIALQLIGLMQRILCSVGVQSFLYPYRVVTTGQDSGIIECVPRSRSRNEIGKLIESNIAEFFVQTFGHPESAGFRRARENFVRSTAAYSVVSFILNIKDRHNGNIMIDAEGNLVHIDFGFLFDTSPGGDINFESSPFKLTTEMVQLIGKNVSGESTLQSKTLARALVDEENYIYFKTLVNRCYLAVRQYAREICVMVELMLQSGLQCFKPKKTIANLAQRLAIDKNEIDAAHYMRRLIHKSRQNYRTVLYDYYQKIVEGIEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RW56</accession>
    <name>A0A088RW56_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Small GTP-binding protein Rab28, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_301680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701193.1">
        <property type="nucleotide sequence ID" value="XM_010702891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RW56"/>
    <dbReference type="GeneID" id="22577221"/>
    <dbReference type="KEGG" id="lpan:LPMP_301680"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300021000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_301680"/>
    <dbReference type="eggNOG" id="KOG0078">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10254700at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001508">
        <property type="entry name" value="Small GTP-binding protein Rab28, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="204"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO00393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="235" mass="25651" checksum="075C31C7475C4D13" modified="2014-11-26" version="1">MDSGSDSSNEGATQFKVVVLGNGAVGKTSLIRHFCDSGFTKSYKQTIGVDFYSRKVQLPHSHSPVTLQLWDIGGQQIGGKMLANYIYGCHAVCLVYDITNLNSFKDLREWKESVDKVFAEASSVAQPKMILVGNKVDLPNRQVTDEHQAAFSKNFSIPHCTVSAQSGEGVNSMFTRIAATLAGVAIRQQDLDLTDRVEVNVASRPEGRQVAPRSLALQATSESKHKRKNGDCSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWJ2</accession>
    <name>A0A088RWJ2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_303060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701328.1">
        <property type="nucleotide sequence ID" value="XM_010703026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWJ2"/>
    <dbReference type="GeneID" id="22577359"/>
    <dbReference type="KEGG" id="lpan:LPMP_303060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300035300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_303060"/>
    <dbReference type="eggNOG" id="ENOG502RXAY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272213at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO00528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="639" mass="69777" checksum="AE491F8D6BE07CD3" modified="2014-11-26" version="1">MRRVSLWLSSHTAGRPGFTPYQIVLKAVEHDGRGLLAAAEVFKQFQRFYRSYQQEETQRAQAPSVCAEPSRTTVGDAAAAAPPFMSGKPLTAFCGRVEDVEPMTVLLLKVLCDLQKLEEMRFLFTQCLLELENRTPSVELFNVFLLAISMTDTFNEYEVENLVELQRAKGVMPDVVTKLSIFLLYLRLGHESCVAWWPGIREEVEIITETGAVARYPLLPLRLQHCFQTLLRLHYDTAVIQESFELLHRAAPERVTPSIVLPYLLLSAMNMSTLPSSVVKVLELLQARERQPSSSPEAAASVEAAGSSSSFSPSAAMTAVREPVLSSEITVFRLLAKCAKHGDADAATYMRSYINTYRRFGLVAKENEPVAALLYVEALTKAGRVRSALRVLESEVPAPYNRPGERPKLFLQSRRLSLLSTDPVRNVVAALTPLVAATHVEDPAMVLVAEKTAAEGAGEREPVPVTSVTLDLLLAACELAGGATRAEQVLCLYPRYETAPTSTTYALLLEVYAATAPVDGALRLPSLQREMEDAGITVDAAWLQAAMAVALNARDIGTAFRIAELNVAHRSCVDVKHGARLLRELAVSADAAAMRRAVHLLRSSNSTVDSRSVALCTAVLRNLGVSTAVLNMDAAAPTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWX0</accession>
    <name>A0A088RWX0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_302230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701246.1">
        <property type="nucleotide sequence ID" value="XM_010702944.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22577276"/>
    <dbReference type="KEGG" id="lpan:LPMP_302230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300026600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_302230"/>
    <dbReference type="eggNOG" id="KOG0529">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266138at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 410-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849">
        <property type="entry name" value="LEUCINE RICH REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="521"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1596"/>
            <end position="1641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="524"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO00446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1691" mass="185446" checksum="E9B65F9C4393AD9D" modified="2014-11-26" version="1">MNEDAGGNSNGETNLVTAGMSPSRQLTAEEEAVLLAEYGFEEPYDNDVQWAAPSHFKSKMGDGHIFLTGAATDDKDAGDSPVTADSFQQGGTTPSRRGRHLVHRDPLRMYLHKNFPSLMLLDRTTPASLMETVTDVLDTLESRSKVNEAHGEQVERHTPTPPLIGFSRSPTLERHAAILRSGKEWARRASLAVQGASIAAMASHLFVSDHQEAPVTCCGDGSSTKAAGAPACTEDIEYRELIESTQQLLSKATEALATRSSLTCDSEAADMAHAVRELQERETLLTEDLLDEYYDRVGVLNDDEEEGEVMQLLCRAREGRARLCAALALRTDDSPVSDIRAEYAAVELVPSAADRDADARPLFSLTPRLPYLYAFELELPILQPVAAESLSASHENILLTQEKHPRILSATHAMPQVVDLPTDSPTEEEKSVSLPRLLMRNTEVLELIGNMELRDAQVQMAAVASREAYLRAYRTGSAARKGETQVRLQNDDRSAHGLAILPSFVQQLDVLLSPTREEQYFRHGTTQPPSLQPDTQVGFNDGTNAAQQQSGSSRGAATSVPLMNTSVEQIRWQAAVESFLVDREASEHHRMRIEDELVQREICAAADQLAEYVQQRSELEQSTLQSVARLHEVQNTAYAELLAAANKGRALAQQAQELRRLQETEKLTYTLIMEWEVQREQLLQDEALSIRSLRRDASDEAQRAQISTQRRLDDEIAAARNSMEELRTIFEQQRVWRGSITLQGEDDAAVAEKVVSLDEKTLRESRWYCWRVAPLLTERAALLRCITKQQKSLESVRTLLVEAEGHYRAHVKASSTSLDSNETPEKVMVLPENPPLMTEGGLSRGHAAAGARVLGADTFVRLLWPSLHAVVRNPQRAPQYLSKLMLSLEDLQQVDWDQLRHMNLSAAGPHQKPAGAVSVARLVKELDVSGNPLRHFDVVEALSTFSFLQSLSISHAQLHTLNSSGAMDTISNTHLRGAPKQHCTCSASATSSRSSHLRHVTAARNHALAAQVHLLFLDVSSNSLASLVPLSTIASSSLVCCTTTENELTDLDSLSGCVQLRELSAAHNRLTDMQAASTMPLLREVDVGNNKLAALTVGRKGGGDDATSNSLMLLSRLYASHNPLHALPSSQHAYLCLTQLFVNHAKLTSLSASSLGWFPMLTVLQAEGNEIADISGVQHCPRLQSLRLSRNRLASLSSLESLRCCTRLQVLDLTGNPCLAADSNDEQLAASVTRALYELVPSLEVLNNSPRAHAREQHQAPASPSTFALAPARKVEVGDFLDDGRHADATLAAIVSSSSRYLSTTPQLYREVFSALCWDAQIQHLLEVKMLREAYAQRPLNRAKGWELSAVAAAAAAGGVKNDGQPLVNRGAAAFAHVHGVTAAQIHTRTAEHLRRVEHFRLDAAAVSEWISLSNRLPLAKLPGSTGDDMLANTHVRNLSFEQQRQDYVGALARAYIAEWLHGRVLVRRARLELLCLRVAYRQSEARRQEAAAQRIQPVWRGAALRSRLRRFLHPEGAGSGAEVEAGDFPKVNVDDWLVENAAALAPVELLFHDVVESAPALIAVPFNVSATAATPVLSAITDASPLPVATTFTPLPPTVGRSHQTVVSGRLAPRSTGDDPPSSDVAETSQPKGSGGALVEQWGPLVAAQIRKKQHKSNRLHQQHLRTEFLQDPLRVKREVREDRAQQRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWX5</accession>
    <name>A0A088RWX5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">gluconokinase</fullName>
            <ecNumber evidence="3">2.7.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Gluconate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_281160</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-gluconate + ATP = 6-phospho-D-gluconate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate acid metabolism; D-gluconate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the gluconokinase GntK/GntV family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.12" evidence="3"/>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700456.1">
        <property type="nucleotide sequence ID" value="XM_010702154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWX5"/>
    <dbReference type="GeneID" id="22576561"/>
    <dbReference type="KEGG" id="lpan:LPMP_281160"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000050900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_281160"/>
    <dbReference type="eggNOG" id="KOG3354">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275177at2759"/>
    <dbReference type="UniPathway" id="UPA00792"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046316">
        <property type="term" value="F:gluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02021">
        <property type="entry name" value="GntK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006001">
        <property type="entry name" value="Therm_gnt_kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442:SF3">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN99749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="142" mass="15687" checksum="92BA48F287159D86" modified="2014-11-26" version="1">MRSGVPLTDEDREPWLHRLREETLAPCQGLSTVSVVLACSALRRRYRDVLRGMGCSKDPQAVADMLQHTEVFFLMLSGDVKLIEERMQTRQGHFMPATLLGSQMATLEALQPAELGTTVDLADPPALIAEKAAELIRISTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RX68</accession>
    <name>A0A088RX68_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_282260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700566.1">
        <property type="nucleotide sequence ID" value="XM_010702264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RX68"/>
    <dbReference type="GeneID" id="22576671"/>
    <dbReference type="KEGG" id="lpan:LPMP_282260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280028900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_282260"/>
    <dbReference type="eggNOG" id="KOG3430">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10033309at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21452">
        <property type="entry name" value="DLC-like_DYNLL1_DYNLL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000015">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF35">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="1" id="KW-0243">Dynein</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="1" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="90" mass="10278" checksum="E0D1731A1E4E2810" modified="2014-11-26" version="1">MTQVPCATVKLSEMPKEMENFAIFCAQEGLAKLRTAQELASFIRKEFERKYGPTWNCFVGRNFGSFVTHEEGSYVYFYVGQTGVLLFKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYB0</accession>
    <name>A0A088RYB0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_300400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701075.1">
        <property type="nucleotide sequence ID" value="XM_010702773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYB0"/>
    <dbReference type="GeneID" id="22577094"/>
    <dbReference type="KEGG" id="lpan:LPMP_300400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300009300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_300400"/>
    <dbReference type="eggNOG" id="ENOG502SKFS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268018at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839172" description="Transmembrane protein" evidence="3">
        <location>
            <begin position="32"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO00275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="26398" checksum="3FF506CD9A102262" modified="2014-11-26" version="1">MKRALGLVCTLVQAAASAAVIALASVSGTSASSVYGLPYSHQHPRSIGGDSNSNKDVGYQPSPPTPTSKSPLVDDVWPNVTLRFFIIFMSVCAGAGVAALITILCAYCREYKLLETSDDSDTESVCSCTNIQFSLSGHSDSSSDEVQTYATHRQQHIPPPATANEAMTPITRKEEEEFIDLPEVVIQTDTQSNESHELFVLPEATSSWSDDALTVTQSTDSRLSLACSRRGFYRKVRCHGTQGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYC6</accession>
    <name>A0A088RYC6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_300600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701095.1">
        <property type="nucleotide sequence ID" value="XM_010702793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYC6"/>
    <dbReference type="GeneID" id="22577114"/>
    <dbReference type="KEGG" id="lpan:LPMP_300600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300011300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_300600"/>
    <dbReference type="eggNOG" id="KOG1177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253115at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF30">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="42"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="240"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="479" mass="54099" checksum="9A2EEACD0105DABA" modified="2014-11-26" version="1">MPAYSEVKSTSGTPVLDQLIGYYVNIQSRKMYYKDFLRIEHQAVRWAFADIRKNSEALAHGLLQTGVRPGDRVLAIQPCNCETFVLQLACAKIGALLCIVPQNAISADKLRFYLNEFQPRHLVAREWISVPEMKQGELVERNMHFWDTIYNVIPELGLSYPGQKFQWVHSQEFYYLKKIVITDHNMNLLGVTPMRKMLVWGPFSYYEQRLRRLSALLHPDDPVLALEDPNPAMEDKLHITYSHRNCVNAGFLFSQLMEFKAETRFGVMPNHHTDPIGAIIAPYAALTSGAVLVHIHSDMFTDDHAINGIEKLCVEEVETLVGRKADFDLILKHAGNFDTDQFEHLRSVVIFEDGIEVPVSEEYLKKLAKDLSLDDVYVFRGPIEASYMLTWRTLKKGSQGMVPHVEAKVVGDRGTSDAKVLAAGTRGNLRLKGPHVTAGYYNNAGLMTELVDEQGFANTSREATIDGTSNITLMSAQTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZK6</accession>
    <name>A0A088RZK6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Heme-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_311120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701500.1">
        <property type="nucleotide sequence ID" value="XM_010703198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZK6"/>
    <dbReference type="GeneID" id="22577538"/>
    <dbReference type="KEGG" id="lpan:LPMP_311120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310018000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_311120"/>
    <dbReference type="eggNOG" id="ENOG502SN9J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="260091at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF25">
        <property type="entry name" value="CYTOCHROME B5 HEME-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO00700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="132" mass="15246" checksum="46D81C0CCCD5554A" modified="2014-11-26" version="1">MSDTETYVRLFYKGASLLVPMSFVLNQHPGGAEYILQYANQDVTSAFEDMNHSTDAHALLNTFAEVEEGELKDIYNPEEYQRKIKLSHSYEERRCTTEMRRWRQRTALVTATTTLAAMAVATYVLRRSLKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S082</accession>
    <name>A0A088S082_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_333220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702411.1">
        <property type="nucleotide sequence ID" value="XM_010704109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S082"/>
    <dbReference type="GeneID" id="22578475"/>
    <dbReference type="KEGG" id="lpan:LPMP_333220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330040600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_333220"/>
    <dbReference type="eggNOG" id="ENOG502RUDM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271595at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839178" evidence="2">
        <location>
            <begin position="18"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="465" mass="51866" checksum="0E93EB6973B72B19" modified="2014-11-26" version="1">MLRRGLLHLARVLSADASLVSLPPNVQRCEVFRNVLSLDEEELIYAELGRVLQREGQTTIWRGSTPEDKVIKHVYLEMFGTEKEFTEVKNWQKKEVCHLPGLLWSPTLLRVLMDVAPPLIGGMPDTARVVEHHVPGYEMHVEHPTVGTGFLYFNLLSDTVLDFDDESTGRRGQVLLPARALMCASGEARWGFRFGEKTEEMHTYVLANGTSIRVETDMRLSVQVWKLNSNLLDGRLLQERLEDSLEMAAKRLAEEPAKRRELEKGPEEAATALQPPDVQTPSLTTAVDPQRPLDLFLAAAMESVSGKGVLGGDLAQSEGGLASGQAGAKKTMGDIRQNYGQYKQQFSKAYNILQDMKVMQDSGQPINDLWLKQKITESSSVDAGKDFQDGFDPSNIEGTWDNVDAKARFYKAKLKMMDYDGTAFLNSRMPDISQDAPLDMRSTIRKMAPHVKDGDKILASLPNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0B8</accession>
    <name>A0A088S0B8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="6">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_321090</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="6"/>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO00995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701795.1">
        <property type="nucleotide sequence ID" value="XM_010703493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0B8"/>
    <dbReference type="GeneID" id="22577850"/>
    <dbReference type="KEGG" id="lpan:LPMP_321090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320016200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_321090"/>
    <dbReference type="eggNOG" id="KOG0579">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001475">
        <property type="entry name" value="Protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF9">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="395"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIO00995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="828" mass="91184" checksum="43A51171057F2D76" modified="2014-11-26" version="1">MRAKRPLRTSGPCFDLTGLMDHAAPELQVQQKNEQELNKFFINVDDNTVSPMITTEPCFHKASDSSLSNTNSAVNSTALEVAGNGGSRSVECRAKGGGESGAVAGASGCLSPATVSAQNEAKFIHVNNTNIFVLIDGISMFVEGKSTFTGTEDARLLVERLRRKKLARSVDTVEEAILNIEMSAGHGVRDGTVPAPRTASSSSLAVEAPASLMPSTTSSPLLTAPSPHKAVALASLFVPQPPAKSVPLANPWASLFEDAKMPSGSPLFRNSTAKSLASISSRSCSPVQGMLLCDSTATGTSLSSPMTTLSPGTAATSTSAFFPTAGFNAAARPPYSVSFPSLRHQDSSSSLVSMASGAGYRNSGHASRSAAVRRTKQISVEEIGHSNCSLDMDDVVVEEMIGKGTQGTVFRVRVDGKLYALKCMNIDEAMNATNDVERQGRKKGLVKELTMITLQRSRPPPAHLMQMFNAVASLDAEKKQLSILMELMSFTVEDIQQMISRIPSEELMRVTQSTFRNYMSGDPSSKQTMKECCKNQALYGSPRHVLGRNTYKEPAAWERSVKRETPMPEVFLSMLARDVLMGLNELHTDYFIIHCDLKPANVLLCYDKQKFKLADFGCGCVMEDRQHVERRGIDLGTMLYKAPERFAANILHRVADGSAGEAVVEFTAKADVWSLGIMLMELAAGVHPCDHFKSDFWNYGGKLKLSKMNKPLNWSEVFYDFILRSVCVEESMRWSVQQLLKHPFVVKFNHVPREKLKQFVQRLEVDSKTFHKRQQSELLKEQILLSTTRRHKDTFQLESKKIWSTYTAYLKHTPPTKDQTIFPELRYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0F8</accession>
    <name>A0A088S0F8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_340990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702524.1">
        <property type="nucleotide sequence ID" value="XM_010704222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0F8"/>
    <dbReference type="GeneID" id="22578603"/>
    <dbReference type="KEGG" id="lpan:LPMP_340990"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270009100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_340990"/>
    <dbReference type="eggNOG" id="ENOG502RZFW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266813at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="507" mass="55657" checksum="13980AC315E3F48C" modified="2014-11-26" version="1">MQARNMTRQAHLIDHVIHAVPVLIVHYCCKLKRQLATLPLLCFCDLLPSPGTADTRGSTGGAAAGAAAAAWLPTEERFEKLPAPDAAHLLLTRWMLAATESYIEKLFFDGSLVVRQLRSKRTPRRLLGWGLRLASHAVFDPLLLSIVVPMLLSWGATPLTGDALSLLPSPPPRVLFTVPGAIRGLMISTVGVITQRLVMPLASQLVDRAVLTVFEAVEYLLMRRYARWSDGEDEDDDYNGDDEENDDRASLASGVSEGAHSKQRVSASTAAITIDGDGPSGTATISAENRVQREQLQLRRERRERHKRRERRQAEREHAMKLAILRAIVYRVVASLAAQSFIDHPLSVLVELLRGRATLHLMGLLQPYATMTAASDGLSWANLWQYVLHLADENVTVRGAMKRGDADEGVPPLVTALRRAGRAIAQEVVVLTSSVLTTSGQTEAIATVQQRAAQTIAQGGIPSAADSADFMARTLLSLSPFYYGIQFTMIDKVLSFYMAVWTRLTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0Q4</accession>
    <name>A0A088S0Q4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_322260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701910.1">
        <property type="nucleotide sequence ID" value="XM_010703608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0Q4"/>
    <dbReference type="GeneID" id="22577967"/>
    <dbReference type="KEGG" id="lpan:LPMP_322260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320028300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_322260"/>
    <dbReference type="eggNOG" id="ENOG502S4J3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268873at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="133" mass="14559" checksum="9556658E94391AF5" modified="2014-11-26" version="1">MGSTSSREWFDPYAINTPLAGVCAVSCLFNSVLNGMLRISNIYTNVTLLILLGCSTGLSNSLQMPLLGAQAGLTASLLFTLGAPMKILFTSRLFPRSVHYGIGAFYTTYHAMQVRRELDYFEDAGEDAEDEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0R4</accession>
    <name>A0A088S0R4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dynein light chain roadblock</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_341590</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
            <location evidence="1 10">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the GAMAD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702586.1">
        <property type="nucleotide sequence ID" value="XM_010704284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0R4"/>
    <dbReference type="GeneID" id="22578664"/>
    <dbReference type="KEGG" id="lpan:LPMP_341590"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340021900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_341590"/>
    <dbReference type="eggNOG" id="KOG4115">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9985637at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.30:FF:000011">
        <property type="entry name" value="Dynein light chain roadblock"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016561">
        <property type="entry name" value="DYNLRB1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10779">
        <property type="entry name" value="DYNEIN LIGHT CHAIN ROADBLOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009998">
        <property type="entry name" value="DLC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103196">
        <property type="entry name" value="Roadblock/LC7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6 10" id="KW-0243">Dynein</keyword>
    <keyword evidence="5 10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Roadblock/LAMTOR2" evidence="11">
        <location>
            <begin position="4"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR009998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIO01786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="97" mass="11021" checksum="4CC4BA2A2D99B2C5" modified="2014-11-26" version="1">MSEIEETFQRISQRPNVVGLIVVDNEGTPIRSTIEDTVVQNQYAHLITSLAAKARHCVRDLDPTNDLCFLRIRSKKNEIMVAPDKDFILIVIQSIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0T4</accession>
    <name>A0A088S0T4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pseudouridine synthase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_342480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702674.1">
        <property type="nucleotide sequence ID" value="XM_010704372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0T4"/>
    <dbReference type="GeneID" id="22578753"/>
    <dbReference type="KEGG" id="lpan:LPMP_342480"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340030800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_342480"/>
    <dbReference type="eggNOG" id="ENOG502QW3P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="447290at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.20">
        <property type="entry name" value="TruD, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042214">
        <property type="entry name" value="TruD_catalytic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326:SF25">
        <property type="entry name" value="TRUD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO01874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="567" mass="63781" checksum="0F510C37C2E0AF95" modified="2014-11-26" version="1">MKWSFDDYIVEEELPSDAFVSSMSVDVKSRTSFVLRLLSEGVPDTVVERQLRERLPRHMPFHFLSPVDFVSCASRYVWLRCDGAQAAQLLSDSFQREQLWHTGTGDVYVSPLQEVRVDPKAEHFPLHLLPSTRYTVTLRNIQGSLGDVLPQLRSVAQNGFLNYSHAARHGVGLYRVYKDTTLLLRREYGEFLRNYLRRLTEGTTQVEREMPVLQEVLASPRSSRRDWSGVVEGMEAAVKCDAQAYARTRQTGVYPPHHDLLLDFVRRAADVAPRHHDSAQIIREAVRPLVLQEALHAITDVHFNALASLRWQRGGDAVAVGDIVRVHDLTSQQPAAADSALDVFVGAADHINGAMLSSAHQEWSALSLEQLRAAPTTAAYRRIATKAEAAQYRLTDVVLPTFGRHVAHLPLMSEEKGDALFATLAKELRVEGLAEMRLAPRAAFRPLLQLPNNMSFYLVDEKRGWDWEEDAGAALLKASLYHDQDGILRYRSPMSRRTGKNMVARLGIRDDTARRFFLKPAQKLGMTCVMQFTLPAGSHATSAIREAFMMATLSPSAIFRLLTARWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S191</accession>
    <name>A0A088S191_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA-specific adenosine deaminase 1</fullName>
            <ecNumber evidence="8">3.5.4.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">tRNA-specific adenosine-37 deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_330270</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically deaminates adenosine-37 to inosine in tRNA-Ala.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine(37) in tRNA(Ala) + H2O + H(+) = inosine(37) in tRNA(Ala) + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:50968"/>
            <dbReference type="Rhea" id="RHEA-COMP:12855"/>
            <dbReference type="Rhea" id="RHEA-COMP:12856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:82852"/>
            <dbReference type="EC" id="3.5.4.34"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>1D-myo-inositol hexakisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ADAT1 family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.34" evidence="8"/>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702120.1">
        <property type="nucleotide sequence ID" value="XM_010703818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S191"/>
    <dbReference type="GeneID" id="22578180"/>
    <dbReference type="KEGG" id="lpan:LPMP_330270"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000012600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_330270"/>
    <dbReference type="eggNOG" id="KOG2777">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043829">
        <property type="term" value="F:tRNA-specific adenosine-37 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002466">
        <property type="entry name" value="A_deamin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46516">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46516:SF1">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02137">
        <property type="entry name" value="A_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50141">
        <property type="entry name" value="A_DEAMIN_EDITASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="A to I editase" evidence="12">
        <location>
            <begin position="120"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIO01320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="598" mass="64580" checksum="9DB7C1360E5D3AED" modified="2014-11-26" version="1">MEGNGASTSTERAGRFMRIAPRLWSDTPHGAVHRAVEAQPQPVWRQLWQRALANGALRPGSSCVVADTSEQEVSAQGKEGAIIVAAFVLSIPFIECPCAGKEEAVESSADVSMRRYVCVSLGSGSRSLAAQDAPASDDGEKVRRLFELRDGHAEVMARRGFVAFLLEMADASARCTGGAYADLFLRRCGGDGDVATVAGVSSCPKWELRETVAVHLVCTRWMCGSLAAVAGGSGRSGHLLLQAACGCWVDSTVQVEALAKEGERASSTVTHVGRHVLATHYSSLNGATQLLHAARVKPGKGLANLSMSCTDKVWRWCVLGVQGRRRASLFPVPMRLASIHILHTSFSDLGGLQTAVNNAAATFQWRNRRWWSHGEREVALPQAPKFSFFSGAEFAATRPMTATKSHDVDVSNDSGYSRSRWLCVSSLVGDRKRSRDEEAEASAFGSVTCSWPYPFTAGDHSCSLVLNTKAGLPQGMTGRALVRRCSTLSEIPWQQCPLSRPWMNHRVQLLLGLGKETALVCPSMATNAASASYAPASIYERSSPTITDDTDLSMSQRVHRYHLQRSGTDGDSIRLLWASSQINFDHLLEAVEGCKGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1B7</accession>
    <name>A0A088S1B7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DDRGK domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_030310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009372">
        <property type="protein sequence ID" value="AIN95266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700974.1">
        <property type="nucleotide sequence ID" value="XM_010702672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1B7"/>
    <dbReference type="GeneID" id="22571897"/>
    <dbReference type="KEGG" id="lpan:LPMP_030310"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_030008100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_030310"/>
    <dbReference type="eggNOG" id="KOG3054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2285710at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044389">
        <property type="term" value="F:ubiquitin-like protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019153">
        <property type="entry name" value="DDRGK_dom-contain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050899">
        <property type="entry name" value="DDRGK_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48176">
        <property type="entry name" value="DDRGK DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48176:SF1">
        <property type="entry name" value="DDRGK DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09756">
        <property type="entry name" value="DDRGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01128">
        <property type="entry name" value="DDRGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839163" description="DDRGK domain-containing protein 1" evidence="2">
        <location>
            <begin position="20"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="38480" checksum="3A3C9C79BA966622" modified="2014-11-26" version="1">MSDVSLALALLLLLAVCGALLLWLISQRNTDSSTVGGPALARKKGRLRSAQSVSGSGACRHGNNSEDESHQDEEDDNGGQDGAAGRRRIGAGGGLHRRRHQRRGANAHRGGSDGDENDHNDDEGAGGIPDTDENGVKMTRLQRKKLAKEREREERRQAQEAALEAQRQRMDASELRDAEVARREEERKAAEEAALQQLREDKKKADDEEYAKWISHIGVEERGELGDEVRKRQARVQSFLLDRAAQVQARAQRSAGGAHSSTSEEECIHVLVLQTAARDLIVSVEELVGTIERLSQADKVHGVFDDRGKYIFIAPEQFPLLAQFIRLRGRVSVQEFTRECNRIVMQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1P3</accession>
    <name>A0A088S1P3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_345070</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="9"/>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02126.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702926.1">
        <property type="nucleotide sequence ID" value="XM_010704624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1P3"/>
    <dbReference type="GeneID" id="22579012"/>
    <dbReference type="KEGG" id="lpan:LPMP_345070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340058800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_345070"/>
    <dbReference type="eggNOG" id="KOG3115">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="47276at2759"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine(46)-N7)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000372">
        <property type="entry name" value="tRNA (guanine-N(7)-)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03055">
        <property type="entry name" value="tRNA_methyltr_TrmB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025763">
        <property type="entry name" value="Trm8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="3-DEOXY-D-MANNO-OCTULOSONIC-ACID TRANSFERASE/TRNA GUANINE-N 7 - -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417:SF16">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 9 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 9" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIO02126.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="241" mass="27897" checksum="DBE0671199FA6836" modified="2026-01-28" version="2">MTSQEQPRWTRLPIRTRPHRNPLAENDDEHPECPAQFAERFAEFYPGVDNPVVEFVDVGCAFGGMLFSLAAVFPTTCMLGLEIRSKVVSFAQEKTLALRQENAASSTLHYRNIWFEQMNVMKFGSNCFKKGQLSRLFFCYPDPHWKRKNIRRRVISPGLVQEYAYWLRHGGLLYTVSDVAELEEWMKQCLDDSPLFRRLTEAELSTSAHQQVLEIVTGTSEDAQRTARKGLQKYFAVHMRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1V3</accession>
    <name>A0A088S1V3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_332540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702345.1">
        <property type="nucleotide sequence ID" value="XM_010704043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1V3"/>
    <dbReference type="GeneID" id="22578407"/>
    <dbReference type="KEGG" id="lpan:LPMP_332540"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330033200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_332540"/>
    <dbReference type="eggNOG" id="ENOG502RYA7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270812at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO01545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="650" mass="72076" checksum="9C2B3314A3E098E0" modified="2014-11-26" version="1">MLTDYWLLADLDGTLVATPHKANGLYLPITQSPCFEPLKQWLGSGGNLCIITTADLRAFNQVYHPLKAFLKTYQEYVNEAAAAGTPLKTVDGTVAQPPRRGCLLLSLYTGAVLYWCTSDSIIMLPEYTSAVHCATRESVELAATYQVRMSHATLLVDGSDNQLRAQSEMYVHGTCIDVETTRLLQTQIESLYLDYVRDVLSGTDLVVRKAVKWLSRRYQCMWGGLLQYLELIYNVVVHQNTTSLLELSMNTEQTLLALEQESPADPAAVEWKINYLRSRRGFLTAVGILRIEYVESHVWFAEGKKGTLHREPSQNIQTQTRDAERAQLVSYVAQVLLADFPATVASRLAAATATMASFLVDLLGPSVRTLPPQMREAKPPTTEPESPPLFSTSTAPPGDVAIVAQVILLGLPLSLFSKYFRSHVEAMVRGGVNAIPQPNSIVFSKMGVSKSTALRYLLGKDRVASLEKDWQLRSTEVTSSPTTGPASRAANFVGCLQRYHGIAMGDNPQSSDFELTVFRDLPFLSVEKESQRVERQQRILRRLRRTQLIEGRGGQPLMPDGSRAPSYAELVSSLRRSGPMMDDRLFGNINYVGGEEEGTALFLAALLHYATAKTKNEQGKMTTVEFRDAVQMAQATSRDQVMLRLPLAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S264</accession>
    <name>A0A088S264_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_351590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703096.1">
        <property type="nucleotide sequence ID" value="XM_010704794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S264"/>
    <dbReference type="GeneID" id="22579188"/>
    <dbReference type="KEGG" id="lpan:LPMP_351590"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350021900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_351590"/>
    <dbReference type="eggNOG" id="KOG0531">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271226at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050836">
        <property type="entry name" value="SDS22/Internalin_LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652:SF3">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO02296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="498" mass="53911" checksum="415BC46D0F14546D" modified="2014-11-26" version="1">MSTAIHTGTGTAHSSRDEDVAVWTLSPQSGEMHDLTLEELYSSLSDLGHNPYGELVYTRSHLASKHLRAVPGLQQYAHLQRLCVNDNHLTELDAVRYMPQLVHLHACHNRLTSDVFASLAASAAGCLEQLYLDDNCITSLDGLEKLPFLLDFTCRSNQVRHLPAHCLSAAQRLTRFSLRGNALERVDTNAFAAAQLLRELELSENLLSSTDFLYSVTSKIEKVNIASNSVRRLSAAVEVLSCLSVLDVGRNELSGLKELLVLRRLKGLRTLEFAGNTGLEHLPHHASGEDGRLGDPLATAMHGTEYHEEVVMSDEEENCRSLCSGGDSSEAPGTASITTATTGAATSAVAAGEGSSALENSSTLSLVFSATDKLAKNAGDSVPKYRRCRSAIPGWGFSKSLAVQAATPTTAAYADLAAPEAHSFVHAMGSMRRDGELDVRVHHQKEVLALPQEEQVYLWTLSVLPQLTMVNGRLIRPEEVAKATFLFGANATEWEGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2F6</accession>
    <name>A0A088S2F6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-dependent RNA helicase, putative</fullName>
            <ecNumber evidence="10">3.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_353070</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="10"/>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703244.1">
        <property type="nucleotide sequence ID" value="XM_010704942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2F6"/>
    <dbReference type="GeneID" id="22579336"/>
    <dbReference type="KEGG" id="lpan:LPMP_353070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350038200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_353070"/>
    <dbReference type="eggNOG" id="KOG0948">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000003">
        <property type="entry name" value="ATP dependent RNA helicase (Dob1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000141">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002225">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.300:FF:000005">
        <property type="entry name" value="Putative ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF7">
        <property type="entry name" value="EXOSOME RNA HELICASE MTR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="36"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="311"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="243"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIO02444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="954" mass="106335" checksum="6B7570D8DCA486DF" modified="2014-11-26" version="1">MSDRCEDKPAAKRARREVDPAITFPYELDTFQKASIDALEDGDSVLVSAHTSAGKTTVALYAIAKALREKKRVIYTSPIKALSNQKFREFSEKFDSVGLMTGDTTIKADSDCLVMTTEILRSMLYRGTEMLREVGCVVFDEVHYMRDKSRGVVWEETISLLPEGCQYVFLSATIPNAREFADWVESIHPTTKVHVIHTNYRPVPLQHYLYPAGADGIFLIVDEKGKFREDNFGKAMTSMGAEGSANGAGAAVPGNGASSGPRGNKGGGGGHRRGGSSQSMMEIVKLVMDRNMYPVIVFSFAKAECERNALALSRLNFNNTEEDALVMEVFGNAMESLAEEDRKLPAIEHLLPLLKRGVGIHHSGLLPILKEVVEILFQAGLVKVLFSTETFSMGLNMPARTVVFTSVKKFDGEKNRYLTGGEYIQMSGRAGRRGLDRVGVVIAMVDEAVEPDTLKQLTGGGADVLLSSFHLTYNMVLNLLRVEDVDPEFMMKRSFSQFQRLRDKPALEEKCAALRKSIEEIHVANESAFRQYTICEDMISKKKGEVNQILHQPKFLKNWVQAGRFVHIIRASDQLDFGWGICRSFTAKNTNPDFSDASTFSIHVAVICLKADVLNPTALTPCPVSEYTSEKADLYTVTFDFSDVQNLATLKTNLPESPDSERGRAEMVQILSKLQRQFGSNVPVLTAAQMGPEDAQLSKLQKQVSNLQKQLEGNVLTTSPTPELQEEFEQYKRKADLETQLEQVKDELAGMGKAVFSEELKQMMRVLRRLDYIDKDNIILRKARVACEITTTDENEILLTELLFKGVLNSMETEMVVALLSCLVNVHRTPDGFSLPQEFEQPLKDLNEVVTRIATVSAESGLMQENSSVEKVMPSLMEVTYLWAKGAKFVDLVSKTTAYEGEIVRMMRRLEEMLRQLASAARSPAIGSIVLHDKFLKGVQLIKRDIVFASSLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2Q4</accession>
    <name>A0A088S2Q4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_342290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702655.1">
        <property type="nucleotide sequence ID" value="XM_010704353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2Q4"/>
    <dbReference type="GeneID" id="22578734"/>
    <dbReference type="KEGG" id="lpan:LPMP_342290"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340028900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_342290"/>
    <dbReference type="eggNOG" id="ENOG502SICB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264763at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839179" evidence="3">
        <location>
            <begin position="23"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO01855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="783" mass="84371" checksum="485FD8EF0B92AA2B" modified="2014-11-26" version="1">MPVVCSFTAAVLLSSAPVVVDALSVEGLDHEERDSYTASGRQQDYPRSVTTDSKSTELSSSSSIVDSKDAPRPDHSRWRDLCGSRAYSRCVLTYVTVTVCVAYLFLPVVLWCLARWWRCGVHQLHRRHSVDDSSGEENDGVMRYRDAEVARHGLLSGRWHDPQDVPDSESARYRAVESSCSSLGTLFQIHNSILQGPRLWGVLQHTPIGLFCTLAQPTGPTGELGQAESLAVDLGEGAIDERRDSWNLSRDADCTVSTSSRASASSLHMHEGVFRATTASDSSDRDKNPSVHRDANNAEDSTCDRCCSRESDCSDDAHTEVKQPALCGVAADEHWSPFRSRTHVRPQVIYFNSAFDTEDDLLTSTYESTSSGSQFLYGSLAAATPSTPSAMGDVLSSHTPPPPTDTTELLLRNSGSSDCALDADALHNTRCAHVALPYMGTALLDVGATCHTDLSINEDSFERGYCPPTLPSSAALCSTVGPRSSEVESVAPPSENTATAAPFSVLQEASYPPVPNETKAALPDAYVPNDRLDTMGGDMVEEVVDSAASSRSYIPTAHLRRLPAAEPPKVRGKRSSARYREPWQPLLVPCKRPSLAEVAGMTTLSTLSAPSSTVCNRVQRAPDPSSLGDDLDNLRLAAEVGGAESNTTGDGTRACRCIRRSRSRTLTLAPGREQGIAGTSVVPTVVPYSDASVCSNLEPTAPLVAASSPFRPQSAPISVCFPTPGAAHTFMDKSDADSSEQCRWLPHGVGQRPSLNLSVEERTLLLRSRKWLFPLIDGTDEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2U9</accession>
    <name>A0A088S2U9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA wybutosine-synthesizing protein 4</fullName>
            <ecNumber evidence="5">2.1.1.290</ecNumber>
            <ecNumber evidence="4">2.3.1.231</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Leucine carboxyl methyltransferase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">tRNA(Phe) (7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)-methoxycarbonyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LPMP_342790</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine + CO2 = wybutosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:37119"/>
            <dbReference type="Rhea" id="RHEA-COMP:11844"/>
            <dbReference type="Rhea" id="RHEA-COMP:11847"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73544"/>
            <dbReference type="ChEBI" id="CHEBI:74275"/>
            <dbReference type="EC" id="2.3.1.231"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36903"/>
            <dbReference type="Rhea" id="RHEA-COMP:10379"/>
            <dbReference type="Rhea" id="RHEA-COMP:11844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73543"/>
            <dbReference type="ChEBI" id="CHEBI:74275"/>
            <dbReference type="EC" id="2.1.1.290"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification; wybutosine-tRNA(Phe) biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methyltransferase superfamily. LCMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.290" evidence="5"/>
    <dbReference type="EC" id="2.3.1.231" evidence="4"/>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702705.1">
        <property type="nucleotide sequence ID" value="XM_010704403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2U9"/>
    <dbReference type="GeneID" id="22578784"/>
    <dbReference type="KEGG" id="lpan:LPMP_342790"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340034100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_342790"/>
    <dbReference type="eggNOG" id="KOG2132">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2918">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="263283at2759"/>
    <dbReference type="UniPathway" id="UPA00375"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46529">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46529:SF1">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13418">
        <property type="entry name" value="Beta-prop_TYW4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 18" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="JmjC" evidence="17">
        <location>
            <begin position="970"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AIO01905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1243" mass="135230" checksum="831C28D828236CF5" modified="2014-11-26" version="1">MSTEPNAAETAPPQAPTEEPSPPPSTSSECTNGGVALSRRKQKKASKVTQRIRVVNGSVDVQVQQTNDDSVVSKRSAVAQGYIRDKFLRHFVKKPSRRSPLINRGYHLRMAIMTDLVVRLVKSYLDAPERQTEVLEGAPCPPPVQVLSLGAGYDTLAFRLLLDSVDVLAVGDKCAGASASSSSSSLSPSAPVSFPGGEVLFIDVDFPAVLMAKAALMAAAPSQTFPEDWHLRPQSADCPIRSPHYSAVGVDLRFASTELLPRLHQHGPTGFVATNPTIIYAECVMQYMPPKDAAQLLALLAAGLPNAVFIAYDQVSPLDSFGRVMQNTLRQKNSPLLGVQSCPDGAHMVRRACAAGMCRAWWADFYRISTFCFAGEERRRVEALEDFDELEEWSEMCEHYGITLATTPLVWDSVATNGCAAHPAFMEYSVDGVACITGVESLPQGTEAIKGTLHNWPSARYGFEGWGNGGVAVEPLSNGDRLLVSFGGFAAGKQHQRVNTVYVHSLQEGELRVVVAGEQSDGAATAGLTACTTHPPPLVFHTFSRVAPRTFLVWGGRSNPSAPSNEAFLLTLDVPDMVSLGSIVTARWRVLCVGSDDRHRCRPSPRYRHSMVNLGGTADKATLLLVGGKTSGVNAAVALECFRVTVCMRRFTISYEALDCTAAGGHLPPPLHSAAAIALSSDAVLISGGVLLGRDACNPHLWQLRLSTKEWFCVPMRLGEGRYAHSLTPVTVNRQEYLLILGGSSWAEKSHVLPALLVPFSLFESNTGSETAAAVAVPVSLPADAPWWSRHSCVTLGQGVVGVIGGGYTCFSFGTFAAKPQLLFLGDIVEESAWRPRFPSACSSNVGRGDGRRTVTALEPVYSYEELLSKPWPAVREVMHYSAAAFLEAATAATQPVVFRNVPLGACLSTWGSSAYLKETEGNTTVSVHVAEKSQLLDFARKNFSFRRVTLAQLVQHTEEATDLFCKTRGTPSETWYYRSIASRMKNERSNVWTDFPALGKDFVLPPGAKEYIEPRLHQSCLRMSAPPLQLWTHYDTLDNVLCQIVGTKRVVLFPPSEYNNLYVTGSSSAVINLEAPDLVRYPRFIEACRAAQQVILRPGDVLFFPAMWFHHVTTLLPDVEPVESAAATMLAPYNMSVNVFYRHFSDTAAYDAKDLYGNKDILAVTRIREDLQSAVRCVLTNPRLTTAADAPVLPPNYVEFAVRHFLQDLESTASAVADAQRGTGTCFDTQTPASHSLPKKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2W6</accession>
    <name>A0A088S2W6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_354230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703356.1">
        <property type="nucleotide sequence ID" value="XM_010705054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2W6"/>
    <dbReference type="GeneID" id="22579451"/>
    <dbReference type="KEGG" id="lpan:LPMP_354230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350050400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_354230"/>
    <dbReference type="eggNOG" id="ENOG502RQNI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268408at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="181" mass="21361" checksum="51DC0043253B217F" modified="2014-11-26" version="1">MRCTRLVCTATPEKFSILGTTHPKPKRNGLGRDNKMRSKPSDNVAWYDKGPVEWLPRPVRLTYDQLDQLRDWMMRETIAGRMEEFSKIRHLHREWSQHPLMPVLGDVEPKFPLNLYKQNHRAKRRFLVRWHKANSPTHWMWMPRGPAVATPLHRTSPSQFPEQWRQLKRNTSSSGSSTVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S312</accession>
    <name>A0A088S312_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA repair protein RAD2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_343450</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702770.1">
        <property type="nucleotide sequence ID" value="XM_010704468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S312"/>
    <dbReference type="GeneID" id="22578850"/>
    <dbReference type="KEGG" id="lpan:LPMP_343450"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340041400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_343450"/>
    <dbReference type="eggNOG" id="KOG2520">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="31113at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09900">
        <property type="entry name" value="H3TH_XPG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000113">
        <property type="entry name" value="DNA repair protein RAD2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039436">
        <property type="entry name" value="Asteroid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001044">
        <property type="entry name" value="XPG/Rad2_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF59">
        <property type="entry name" value="FI23547P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12813">
        <property type="entry name" value="XPG_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00066">
        <property type="entry name" value="XRODRMPGMNTG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="7">
        <location>
            <begin position="635"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="162"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="432"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIO01970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="917" mass="98411" checksum="8F1B067B25CE8B18" modified="2014-11-26" version="1">MGVRGLWRLLDSFGVVLQPDELKGKRVAIDASIWIAQFRARVAPGEDIEHRVLEGFLARLLKLLFYDIRPVFVFDGTASSSKSAEHHHRMRQRARNAQALVKRRARQILMAQVVAGTLDVEDLKAVMSSDAQAEEDAVGAAKGSDTSVPSVAANTAERTAVSEMVPPGGGSDHALGASSSTRSNAAHGEKRPREASEVLPLPGSHRRRRSLRKHRLAPDVVSETITQGFLSVMKDLLEERTRHAACVSHNVLQNTSTSLFIGPRCVVDEYAEDVAGVATSGHRQPPHLYCTASAISVSGDSQEDGSGTDYVIVSDSERDAEATSSVCCTIASADGEEEVSVVEEAVLVDDVGDSGLADAADRKRSLSSPARLPSTVTAMLQSGDMTWFLNALSQPTCTLPPELMSPATAAERASPLITSSDFTVQSVSADEDVAPDLSSRSSNSSKSLTFTDGSNDDDSVGTGFAWEPFTQQLHSTQLLRQQAKKSEPQLHSSCSAAAQMVAASVSGGVATDAATVGTEDEDGGDYTPVKAGRMFSRRCTAPGLLPVVESLRHSGSDERSNVPIPLLAPCTNTLTDTASEAAGTPRRRRTEVHSVANDGTRSMTGVPPRGGGGGAVRMSRAVVPFELLNVVELLDCCGVPYVLSPAEADAQCAFLARRGLVDAVFTEDSDVLVHGATTVLRGFFSQSKHVVAYEQTHLSACGITKTVLVALASLLGCDYAEGVSGIGLVGALKALVVAWTAAENAEDGAASSSAVLHVLRRWAQLVQRPPHSWQEVDDDMCVLQFALLQADLAQWRTLEHRACFPEAHAVEAFFDAEVDSDTTPFEWLPPDWQRLRVFAAALGALSSPWLVQKYELARKECLRREEEAAKARASLIAGQRRLTEYGLQKRVRARWAFQKQPPKHAAILAKLRAVQQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S326</accession>
    <name>A0A088S326_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Rib72 protein-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_356550</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703583.1">
        <property type="nucleotide sequence ID" value="XM_010705281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S326"/>
    <dbReference type="SMR" id="A0A088S326"/>
    <dbReference type="GeneID" id="22579683"/>
    <dbReference type="KEGG" id="lpan:LPMP_356550"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350074900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_356550"/>
    <dbReference type="eggNOG" id="KOG0043">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10255210at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060285">
        <property type="term" value="P:cilium-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.170:FF:000009">
        <property type="entry name" value="EF-hand domain (C-terminal)-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.170:FF:000010">
        <property type="entry name" value="Rib72_protein-like_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.170">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006602">
        <property type="entry name" value="DM10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040193">
        <property type="entry name" value="EFHC1/EFHC2/EFHB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12086">
        <property type="entry name" value="EF-HAND DOMAIN C-TERMINAL CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12086:SF9">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06565">
        <property type="entry name" value="DM10_dom"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00676">
        <property type="entry name" value="DM10"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51336">
        <property type="entry name" value="DM10"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DM10" evidence="10">
        <location>
            <begin position="83"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="DM10" evidence="10">
        <location>
            <begin position="249"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="DM10" evidence="10">
        <location>
            <begin position="422"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="576"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIO02783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="741" mass="83800" checksum="25EFD758EEE7AF4D" modified="2014-11-26" version="1">MSIREKTVYNALPKLPGFSFAELQHPVTHGRRQYCTIDDKGTRTVKDAAALDGSAIATASAPDGCGIPIRIILQHFPSWRTLDDKVLRFFAYYTEDVVASSIETWRVRKVKLHYFLADGSLGIVETPAVANSGLQKGTIVSRFRPDGVDVFRLCIGASIPCRGLVCKLVDCDAFTREFFEVMGMPQPEPLGYPQDDFEARAMCRPDKMDEQHIEMRRVIEVQAATRAGTHASLLTPAERAKARDFYEYDRNVLRFYAVWEKRKFRIYFYLADGSIAVLFDKAENDGRDPYPVFVRRRRIPKEARAVLLSSETLNRPQGPVPACLTAEDLRTGTSVDIFTRPFFIYDCDEHTRAYMEARNIPQPAVPAPPCEEDEITVGKRRPRLAKEARNAAGDSGKRFGASTMVFDDSAAGKDAVKMTRYAHDVFRFSAELAQSSEENEGRRFMICYYLADDTVSVYELPVRNSGHLGGKIFARRAVENVKDPTLLKVGTTIRLDGVDYLLKEMDERTKRCLEMGMPNMEEAYFRTQEILGIVASYLQQQFSRITDAFRHYASSSTQGLTRENVGEILSDAGVHATDAELTNVMERADGDKDGWVSLADFTEQLMQQQFISTFKPRESQREWGDIRNGVTVQRGPVQSAMMLAKKADAKAQADAALQRFLTLIEARRTFAIRSFRSASQSAYDGNLDMSEFQNCVKDRLKTPMTDDEIGALLYKFYYTPGLNDWTARRLPVQEIQRILLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S452</accession>
    <name>A0A088S452_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sec20 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_110300</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SEC20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696879.1">
        <property type="nucleotide sequence ID" value="XM_010698577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S452"/>
    <dbReference type="GeneID" id="22572895"/>
    <dbReference type="KEGG" id="lpan:LPMP_110300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_110005300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_110300"/>
    <dbReference type="eggNOG" id="ENOG502S59C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267919at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005606">
        <property type="entry name" value="Sec20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056173">
        <property type="entry name" value="Sec20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825">
        <property type="entry name" value="BNIP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825:SF0">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SEC20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03908">
        <property type="entry name" value="Sec20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Sec20 C-terminal" evidence="12">
        <location>
            <begin position="165"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="75"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIN96226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="264" mass="28938" checksum="F9A911AB091BBB92" modified="2014-11-26" version="1">MEVAAAARAAAASPLPSRTTEVLVALAHRADRAQRELITTHHAFVSSRTQRLHGALSIAVAHAQQVLRALEAVREQRDRERHQGHQQRSGPSASPSTQAAPPSAESPAPTKEEHQLHMRLEKARIDLRRVLPRSVAKVEDTSNVCEGDRTSTSDQSAARTAAALRSLLHTRSMLSVELKKMDTAVQGLAGSSESLATLQQSLQDVHSSMEMAQRMVRTLLRVQSRDDLLLRVSAVLFVLVVLYVVAQRVFRLFPTTVYVTVAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S583</accession>
    <name>A0A088S583_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_357080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703635.1">
        <property type="nucleotide sequence ID" value="XM_010705333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S583"/>
    <dbReference type="GeneID" id="22579736"/>
    <dbReference type="KEGG" id="lpan:LPMP_357080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350080500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_357080"/>
    <dbReference type="eggNOG" id="ENOG502S28N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040214">
        <property type="entry name" value="BRD10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31095">
        <property type="entry name" value="RIKEN CDNA 9930021J03 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31095:SF3">
        <property type="entry name" value="RIKEN CDNA 9930021J03 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="3">
        <location>
            <begin position="58"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO02835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="286" mass="32821" checksum="759ED8A41BBA3349" modified="2014-11-26" version="1">MPSSDQVLVDALRSRLKRRRSDIFRYLDALFYEDCRRIMECVSELDSNDLFLRNPSSLPDYAQHVPRPMYWELINRKLQRYEYRAAADFMADMRAVVNNCYLYNGVQAPASKVARAMEVLMEDRFVTELRATPVPPAEVKKACIGMSSADSREILRIYTFYEGLEVSTTSGNTNIQLRSAKSATLRRMLEYARSSAEHREKKARLRHAAKVSRVSDRRRQAMAGAQAAVMQQDAAVQFHQDAEPRLEQVPQNAQAAMPMMEEVSPIRIEEEGEWLDEGDLEESSPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S5E9</accession>
    <name>A0A088S5E9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_141330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697364.1">
        <property type="nucleotide sequence ID" value="XM_010699062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S5E9"/>
    <dbReference type="GeneID" id="22573400"/>
    <dbReference type="KEGG" id="lpan:LPMP_141330"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140018900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_141330"/>
    <dbReference type="eggNOG" id="ENOG502S24Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272310at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="615" mass="65207" checksum="D31D71FB0150C2A7" modified="2014-11-26" version="1">MPLMSSQASAVPSSHLLSLGDGSDVNVTASSTASPAPPRNPRATVSNASHYAAKDVEAVELDPAALWAVLDLPAPESMPSQHTSRRVVLLGRPLSGKRTLCRRLCFAAQAQYAGSDGATDGGPQSGGVAANNDREPLYHPSTDDDEDSALFPNRNVGGCNMPGAYSTGGTPRQCTGVGPQDRVKPLSHGSGVCFDYVVQRVPTRLAHGCGGANDGLASGNQRSSTGFLMAPLGGTVRRTTEFFCCDNAGALSMALPTLDHVESGLVLMVIDVSDVSTIRQQLDYCYSTLESYIANLLRTQAPSHDEVRRMQLAAAQQEYWFAEEQKLRTVRANLASGGTAAAASSSSLTKECLFDASFADSAASVDKANSTPLRVPASAGTVCTMRSVIVCTKVDSLERASRAIGLVESGTIESEALLDRLGIPGELRLAMRHSLQSLLCLVSQLVRQYAIYHRAALASVCLRVSMTTAGAEGEYANSALVNPFYKGFWAYIAYLLYSSEGPNASVPSDVLRVCSARMYPHALLPCGLDSLALLNHFVTSSNVQLPEGPSLMAPEDPADSAIRTTAEGVITPDGVFLLHQKYIQQAQADLTSWTALWGNPAEAMHSGDDMVWDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S629</accession>
    <name>A0A088S629_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_161260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN97001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697654.1">
        <property type="nucleotide sequence ID" value="XM_010699352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S629"/>
    <dbReference type="GeneID" id="22573705"/>
    <dbReference type="KEGG" id="lpan:LPMP_161260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160017900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_161260"/>
    <dbReference type="eggNOG" id="ENOG502S6BY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273555at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="563"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1020" mass="107276" checksum="DEE080F77D587559" modified="2014-11-26" version="1">MSYDTNLHRTFDYQLSPAPLRIIDWAPVKSIARSVLQPGRGAKAFTLVNDATSNAPSVAATYVQQENQQRVHGNCGPSATVAATADSAAPGVPLSVIGESAASEFPSLSVASPYDTPGMNSGAAAAAGGGGGSHTELYILQVEDALVQQQQRQQLDTWAATPGELAGGATIGNAAATPAVLKHTLAPSAETTGGMAVPATAVLASSCCNSAQRTGTSTPATIMDSAQRLRASPSSSVAPSLLAKGVSHYSAAGMMYGFDSVYHKDSFGVMTGLVTGAGYHQVNTCYRQEQSSPPRRTEKAKGEHGCWTGLAATTAGTSQTLATVASPTLQSGSMLNSTANRSSSEQGPSGAVDTVVGTSAVELQAAEATVPPSPPTHKSWLGPVIASQRHGHLQIYNALQLFWYWGARRWTGVLNVRVTPLPATDALLPVCEYVARTVMTECSIVIDDPIMYMHGFVVMLGRRTRTAEELGSGHSTGASASRVVVQNCNGLYQSEPSQDQVGSRHPLVAAAAASLTSGAADTATTGTRHHPAEGIGHFSTSPASEEHRDAEDRRVGMFIGGTSAESPGSAGVASSPPSPKETPSPPHMHSPSMPSARHRLSNPPTARTPTDSDHEHSAAHCNAAVPPGTATNNTGVVPMPEWLYWYQRCMLETTDEWLWNRAASEVADEASRSATPWWKLRHIKMGVGLALRYRKPRGVNVYWGWSARVGRGLHFSGHIDVLRRMSCAVSSTFGFLDVSVRLRVNLVTLHQTALDAGVCWRPMPQVPEFAVRLATSANGTTLGVEMADVAPKLYGPVIGRLSDWRSRRHHAVTTEPHAAGIEKGGEACVVVAIPDVAELPANSDQSSVCGGAPPGVADSSREDLVGLLPITWHYLKGTGSTITSAFSTVKAAVMNTLAAVPSASSSTGSNGIGGNVANTSTAQGNVPDMRRPPVPLSATPMFSTPATPSTLPVKEKLSRIALPAGQASLRYARNAWHALVDLGWLEKMLSTSHVNVSIGVTSEPSDRHREWSLFFIISEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S8M2</accession>
    <name>A0A088S8M2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-directed RNA polymerase 2, RPB12 subunit, putative</fullName>
            <ecNumber evidence="2">2.7.7.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_204730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.6" evidence="2"/>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698673.1">
        <property type="nucleotide sequence ID" value="XM_010700371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S8M2"/>
    <dbReference type="GeneID" id="22574685"/>
    <dbReference type="KEGG" id="lpan:LPMP_204730"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200054000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_204730"/>
    <dbReference type="eggNOG" id="ENOG502SG5Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="257852at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.30">
        <property type="entry name" value="RNA polymerase ii, chain L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="95" mass="10750" checksum="441AD9C42DE1A6DA" modified="2014-11-26" version="1">MSAPLTKKEVKQEERKYSDTAATQESKHDIFATQDTFGDLAQDEKEGTLYVCGNCTAQLYFKPDSRLLCPICSHITGVSTVFYKIRTEPTMYDTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S9I3</accession>
    <name>A0A088S9I3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CLN3 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_220010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the battenin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98296.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699003.1">
        <property type="nucleotide sequence ID" value="XM_010700701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S9I3"/>
    <dbReference type="GeneID" id="22575047"/>
    <dbReference type="KEGG" id="lpan:LPMP_220010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220005100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_220010"/>
    <dbReference type="eggNOG" id="KOG3880">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="246817at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003492">
        <property type="entry name" value="Battenin_disease_Cln3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981:SF7">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02487">
        <property type="entry name" value="CLN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01315">
        <property type="entry name" value="BATTENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN98296.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="627" mass="69209" checksum="A365D6266404E256" modified="2026-01-28" version="2">MDVLDGETTEECRKAGAAGNLSASLAHSPASGIEESDRYKRDMVTLHGLFKRTMIRNSVFLWLVGFINNFHYCLVISAAASLAEGYGLKRLVALITWANIFFGIFARILNMFIATRVSYNVRITAMTLSSLLGIFFVSFATPIGRHNNVSAFAVMLIGVVLLGTAASYGESVMLTFLQRYPNSIVGAWSSGTGLSGVAASLIFLGLTSAGLTQQQTFLVSTPLCIAYWLCFMVGMMSPHKVLVATHASGKREEIILHCLEGEEGEHLSMLREKALARSDIVSVAEGYKIKMIVNIRGVSWSQSPAVHKAEPSPEEGDGLYYPCCRVVCGCSSPNNGLRRWWRNFGPDMIFMHNTMFWFFFNLAVVYIAGYAAQLMAPFSFYCEPAWKDNFWVKNSYVVSQFCYQVGVLISRSSLLIVQIPYVGVISIIQIINAVCWIVQARVLYIRSPTKSRQVGLSFILFAWMTLIGLMSGASYVNVFYLILKRSTMLREREENEAVKAYLASKSHDSSRLGDAGGSALTRKTADGVRSESALTGLDRELSDEVMPNYLQNDTAGAASEDQNLGLDLTNDEQEEIKAIHRNLNDVWAARREMGMNIGALYATIGITLGTVVDLILTNTMLKHSKSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SA10</accession>
    <name>A0A088SA10_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pteridine reductase</fullName>
            <ecNumber evidence="3">1.5.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PTR1</name>
        <name evidence="6" type="ORF">LPMP_230300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.33" evidence="3"/>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699188.1">
        <property type="nucleotide sequence ID" value="XM_010700886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SA10"/>
    <dbReference type="SMR" id="A0A088SA10"/>
    <dbReference type="GeneID" id="22575234"/>
    <dbReference type="KEGG" id="lpan:LPMP_230300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230008300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_230300"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047040">
        <property type="term" value="F:pteridine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05357">
        <property type="entry name" value="PR_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014058">
        <property type="entry name" value="Pteridine_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02685">
        <property type="entry name" value="pter_reduc_Leis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="NCBIfam" id="TIGR02685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR614058-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR614058-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN98481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="288" mass="30537" checksum="224F23E56D83CCB8" modified="2014-11-26" version="1">MMSVATVPVALVTAAAKRLGCGIAEILHAQGYAVCLHYHRSAEDANTLAATLNSRRPNSAIAVQADLSAIATASVSNAHGAAPISLVQRCAGLVDACYNHWGRCDVLVNNASAYYPTPLLNKDEEGHEPSMNEETEAAAAADLFGTNALAPFFLIKAFAQRVADIPAEQRSDNYSIVNMIDAMTNQPLLGFTMYTMAKEALEGLTRSAALELAPLQVRVNGVSPGLSLFPADMPSAVQADYRSKVPLYQRESTAEEVAAVVFFLCSSSAKYITGTCVKVDGGYSLTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SAC2</accession>
    <name>A0A088SAC2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="27">Dynein heavy chain, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">LPMP_231470</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 28">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699303.1">
        <property type="nucleotide sequence ID" value="XM_010701001.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22575352"/>
    <dbReference type="KEGG" id="lpan:LPMP_231470"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230022700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_231470"/>
    <dbReference type="eggNOG" id="KOG3595">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="447173at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000153">
        <property type="entry name" value="Dynein axonemal heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002141">
        <property type="entry name" value="Dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000001">
        <property type="entry name" value="dynein heavy chain 17, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000001">
        <property type="entry name" value="dynein heavy chain 2, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000009">
        <property type="entry name" value="Dynein heavy chain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000044">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000009">
        <property type="entry name" value="Dynein heavy chain 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.280:FF:000022">
        <property type="entry name" value="Dynein heavy chain, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.130:FF:000003">
        <property type="entry name" value="Dynein, axonemal, heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000049">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000016">
        <property type="entry name" value="Putative dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000028">
        <property type="entry name" value="Putative dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002138">
        <property type="entry name" value="Putative dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054354">
        <property type="entry name" value="DYNC2H1-like_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703:SF32">
        <property type="entry name" value="DYNEINS HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22597">
        <property type="entry name" value="DYN_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="240"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain linker" evidence="18">
        <location>
            <begin position="1416"/>
            <end position="1817"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain hydrolytic ATP-binding dynein motor region" evidence="19">
        <location>
            <begin position="2001"/>
            <end position="2327"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA 5 extension" evidence="23">
        <location>
            <begin position="2502"/>
            <end position="2629"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein 2 heavy chain 1 cytoplasmic ATPase lid" evidence="26">
        <location>
            <begin position="2834"/>
            <end position="2917"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA module D4" evidence="21">
        <location>
            <begin position="3004"/>
            <end position="3266"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain coiled coil stalk" evidence="20">
        <location>
            <begin position="3280"/>
            <end position="3611"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain ATP-binding dynein motor region" evidence="22">
        <location>
            <begin position="3640"/>
            <end position="3861"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain region D6 P-loop" evidence="16">
        <location>
            <begin position="4114"/>
            <end position="4224"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA lid" evidence="24">
        <location>
            <begin position="4259"/>
            <end position="4403"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain C-terminal" evidence="25">
        <location>
            <begin position="4410"/>
            <end position="4720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="22"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="3495"/>
            <end position="3565"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="3809"/>
            <end position="3871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF03028"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08385"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08393"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12774"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12780"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12781"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF17852"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF18198"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF18199"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF22597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="AIN98596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="4724" mass="540359" checksum="3EBFDD5D801EB01D" modified="2014-11-26" version="1">[encoded data, 4724 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SBX9</accession>
    <name>A0A088SBX9_LEIPA</name>
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        <submittedName>
            <fullName evidence="8">Qc-SNARE protein, putative</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="ORF">LPMP_260670</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="AIN99181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_260670"/>
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    </dbReference>
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        <property type="component" value="Chromosome 26"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
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        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SNARE fusion complex"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="7">
        <location>
            <begin position="159"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN99181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="250" mass="28278" checksum="DE8933CB6F7F3F25" modified="2014-11-26" version="1">MSLASRAQTGAAVLPTVTAAADGATHEDPWPQIEKQVGAMLADLNAQMQRFHNTSVPTVIAENELLESVDSCNEAVEDMRFALDTTMEHPESFSITAEELQSRAERIRAWEREMMKAQQVAEKVRAAQRKRMMAQDGDADDNGTRENTDFLRQERDIQRHIMQQDDQTLDRLSSGIHRVRDTAVNIQDELKTQEHILDDIDRGMTRVQMRLEGAMKKVSKLIDSTSDRGKMICIAVLFVILVILTFVVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SCX5</accession>
    <name>A0A088SCX5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Endo/exonuclease Mre11, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_271870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700273.1">
        <property type="nucleotide sequence ID" value="XM_010701971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SCX5"/>
    <dbReference type="GeneID" id="22576365"/>
    <dbReference type="KEGG" id="lpan:LPMP_271870"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270026900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_271870"/>
    <dbReference type="eggNOG" id="KOG2310">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="30417at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097552">
        <property type="term" value="P:mitochondrial double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.110.110:FF:000006">
        <property type="entry name" value="Endo/exonuclease Mre11, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.110">
        <property type="entry name" value="Mre11, capping domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038487">
        <property type="entry name" value="Mre11_capping_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007281">
        <property type="entry name" value="Mre11_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139:SF1">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04152">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01347">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mre11 DNA-binding" evidence="3">
        <location>
            <begin position="288"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="532"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="690"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="822"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="830"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN99566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="863" mass="92592" checksum="AEA383728D61FF6D" modified="2014-11-26" version="1">MSECTFKFLLTTDNHLGFAERDPRRGDDSFTTFEEVLRAARTEHDVDAMLLGGDLFHENKPSLGCLVRACSLFRKYVFGNKTVPFSLLSDAATNFPTHALPMANFQDPNINVALPVFAIHGNHDDPVGGTSSLDLLATNGYLNYFGHVTSLDDIILEPVLLRKGSTLIALYGLGNVRDERLHRCFRLKKVQLVYPKPVPGRKWFNILVLHQNRGVRGLASKGGIMEGMLAGFGIDLVIWGNEHEQLMVPQPSDGFDVVQPGSTIMTSLSAQECNPKEYGILEVRGTSYRLTPYTLRSVRPVVRRTVELRQDLPDGRTLDAVETFLHSVMSDMISEAEEHVSHIPDDVLTFHPNLKYPLIRLAVDFTDVTSAPYPQPNFNRFGQQYMDVVANPGELLRPVKPKLERRPGGGALGTVLGPGGASASGLIVPAAPQLNTLDIRVKVADVFNHNTKNACTLLSEAELSAAVYAFAEKGERDAIDERLMELLHTSQKSVWRRLENGANDSILKPDRVVEEIVTHKRHVNERYARAAQLEDAQQQKEQRDDAEENEDNGVASERQSRGGAASRSLHQAERECELDSFAVMRAAAPRVGLAASDIGDGNESHFSGRFAQTSVSRLVERAIQQGSENGAGAAAGVPRQRAPRCGGAVVEVDADGGGADDDGEELPDDGLGRMPIDSVIAQAIQQVCPPSKRARSAHAPNVKPVLAGDNGSRHGVGGDGHDGNTLHVVDGDNWDDANSGRGYGTSRHGCSHIGASDSAKVPAPAKKQQRTNSARRGGGSGVTARQGAPSAANAGALSAASAVSAGAGPTLTFVAHQGCSAVLSPGRRPASSTADSAEGVSTSKGAMLNLLSKWTGGSHQQQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SD15</accession>
    <name>A0A088SD15_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_272320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700318.1">
        <property type="nucleotide sequence ID" value="XM_010702016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SD15"/>
    <dbReference type="GeneID" id="22576410"/>
    <dbReference type="KEGG" id="lpan:LPMP_272320"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270031500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_272320"/>
    <dbReference type="eggNOG" id="ENOG502S67D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270291at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="27935" checksum="09C12B1B1B221078" modified="2014-11-26" version="1">MDQGAVSEWNVVGTFRKRPVPQGPIVDFTVDVSHQISLDNTDAPILLYEMKGDKNQQESRVPRYMARKIAIPPPSLHKMRVVSLAPPRSTDTGARSDEDLFFVDCPERPSAPSNHRNRVHRQQPLVIGTILPPPLQLAFLMPFGVFLIDIALLVASLTTYKPEKALIVACCILVLVPDIGALILLFKGGIYFLTIAVHLLLWPNIVLLFLQPFVSLLFMVHFLLTTLMLLYCLRIRTSVYMTFYRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SEB4</accession>
    <name>A0A088SEB4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Asparagine synthase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_291540</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700759.1">
        <property type="nucleotide sequence ID" value="XM_010702457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SEB4"/>
    <dbReference type="GeneID" id="22576917"/>
    <dbReference type="KEGG" id="lpan:LPMP_291540"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290019500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_291540"/>
    <dbReference type="eggNOG" id="KOG0573">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10252281at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051857">
        <property type="entry name" value="Asn_synthetase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937:SF1">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="19"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="379"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="382"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="396"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="448"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO00102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1226" mass="131835" checksum="2FC941EE9AE122C8" modified="2014-11-26" version="1">MCGICLLVRQKLVNATATTTSALASPQQSAKSSPAVPHSNPFYPPQDEAEQQQQHHHHRHHPNGISSVASFPSSAVQTHRLTPCLCPQAGLDAKDFLSSSGDSPTVNYLFDEMVRNLRRRGPNAYGVTRRSFSTVCQVPTDGGVSLTHPVPLMTSVDRANGGNATTNAAAPHVSVPASAAVHVRTEVAGVASVLGLRGHSTVAQPYDVNVEADAEEDDPANSWDYRSSLLWNGEIFGGALCPPPWGSDTVLLASRLSQMELECVNMSQENAAGPKHLPLAQRQRMFLRKCTTLLEQEVEGPYSFIFIAARLRLAIFGRDPLGRHSLLTHIRVMVPPSKAGHRWPATATTRTAPVATHEVPAELDVELIVTSVGVQHRLPASPKTSATEVANTAPTSALSSSSHMASSNSHLSCPKDPAKVEGGNAAKPKRPRHEKAESVATSPPPPSSALSGPVLLSVPSAGDEEDDSGDASSAGFREVCWQEVGVTGLFAVPLQAPLVYRDTATAAALEAETWSADIAVSEDRATHQPLNLHPVCLSDEAVVSGAGDGYQATLRAAHMLLLHCPWQRSNHLVHPLLRTVGLPMVPHEPPSFELILAHEEIAVLPEPLLQWARHLMKSIQPGEALDQSWVDWAAAHYMLALAVSMHRRITVANAGAADGSDAQELTTARRRPLCILFSGGIDCTVIAALAHYLLPVETPIELVNVAFGETPEQAPDRVAAFRSMEELLRLPLLHTLGNDAAAGATGTPAATPEREWRLILVDVPSKSTSDSAHIKDLLMPRHTVMDLDIGTALWYAAHASGRMQTLCRSDVLGSDTPATTEACGGPILPAAPVHTDMGSPTVTLDEFSKHFRAYTGVTPVTSCPPDGAVSDVRPPGTSSALLAPNATHMTATALLPSSSAASVDTDSVANTQKYQILVDVLVKEGRSGSGPHTPVLLSTLGKEYSLFLQPHIKRYSYKKLGSFLNDAARAGYVQFAPDAPSKAVRLCRPCDMLRAAAVPPSPWFTTVYMKAKEPMHAADGSVQPAPPCPGTCQASYVSQAKVVLLGMGADETLGGYTRYRRFFQREGMPGARRELQRDFARLWQRNLGRDDRITMDSGREPRFPYLDEGVMRTLEWTVLKRRNNILDTRELLSRHTAESGAAAEGAVLSTTSNSREGAPPLTSDELLRLALEPIVNFHLKLGEGDKRVLRRVASVLGLSGVTHLQKRAIQFGSRIAERKIKGTNDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SEJ5</accession>
    <name>A0A088SEJ5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Kinesin, putative</fullName>
            <ecNumber evidence="1">5.6.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_292400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.6.1.3" evidence="1"/>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00187.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700844.1">
        <property type="nucleotide sequence ID" value="XM_010702542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SEJ5"/>
    <dbReference type="GeneID" id="22577003"/>
    <dbReference type="KEGG" id="lpan:LPMP_292400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000051800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_292400"/>
    <dbReference type="eggNOG" id="KOG0245">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO00187.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="589" mass="64939" checksum="3B17009CBE3F1C26" modified="2026-01-28" version="2">MNPSDSLSRVQVSLRIRPLGKGDRHGTKVVVRGVEGGGVVVDDRRKTKRTYQFDYVFSGGQAEVFEAIGRPMLEEAYKGFNVCLFAYGQTGSGKTYSLLGDVGSEEHAGVAPRFVRCLFDEAQRMVDEDADLTIKVSLSMIEVYMEKVRDLLVPRQRGQEPESLEIHEDPSRRVYVRGASVHQVLSAERMMELLRKGNASRQTAETRMNETSSRSHAIIQITVSQEFASVEKKDLECVVSLVDLAGSERQTKTESSGQQFDEARKINHSLLMLGRALNSFSERKGSDVFISLRESKLTRLLSESFGGNSKTWMLATVSPTAFNLTESISTMDYATNAMAITNKAKVNKSSRDFEYSDLLKMKKYLEVSAARETSQIESYVAETAELKAEIEALNQELLTLNDSQLEAGLQEALSERDALVSEMVSKLAGVGLRGGGAPLVCFCGTCKTSLCSIPLGSYEVNTLVVPLYDLVGPPPLLQCNLHVQLTETNDVMVVVELVELHHLPDFATGGVRASIWFEGQASSRVVTPIVSPNGGNPKFNFKQVYIFGPLTGELQRFFSADVLYLQVEGITSVSEDLLDRDDVEAQCLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SEV2</accession>
    <name>A0A088SEV2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_300990</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
            <location evidence="1 6">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701132.1">
        <property type="nucleotide sequence ID" value="XM_010702830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SEV2"/>
    <dbReference type="GeneID" id="22577153"/>
    <dbReference type="KEGG" id="lpan:LPMP_300990"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300015100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_300990"/>
    <dbReference type="eggNOG" id="ENOG502RCPW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271850at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1900:FF:000034">
        <property type="entry name" value="Spindle pole body component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF27">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="8">
        <location>
            <begin position="333"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="741"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="749"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIO00332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="782" mass="85070" checksum="12091F4A22557839" modified="2014-11-26" version="1">MEEVKCSLLGFNSALLRQPLDTLSSAADTRTTKEWSADSAAGASSAAALRRYCEALPFHPTERLLLQSALPLGRSYHTLLRATQEAAVGRTEGLYPAAIANGVKKILVNYAEAVKAAETPSALAVLPATYILTFTLLEAIVKQQQQTEVCLPLLGDFLHNQEVPAVFRRLLGESVWLALLYTTAHYVAHGVVLHARRDYFIALRTKPTETAAAAVPVGSTSTRFRCGGEEHILYTDRLPLGVSPELGLLILAAGKERRVLLRDADVQGGSDYLEQLALGSQDEAANAVFHSIFDVQLCHGGVLAAEELAARVEAAKTLWSKALWMKVGDFPSLKANLAALRNMFLCHRGDVWYAFVERVLSVLAGLQPIQHGGCEGAAASPAPAPLLPSLSPAATIEGAEGANEEEAKGEDAADALARESRAVASRGAYLQRTAADAFLFALSVSNLHDTAAYEPFTMRVAASSIQQANAAFAGEDQGRAGRRTRGGGGAAASTEDMARHLLLVVQALHLQYIPPQGLLLIVSQKSLQYYQRLFSFHLALRFSLEALAVTRSLFSEALVTNMSPSADLRRAFSLFQLLHFLESSVGYYMQVDVISVYTAQLEEQLASTTCTSVDQAKHFHDQFIWHVAEATFLTEGSEPLLRACQSLNTCATTLYTLCTRYRISYWAVDGVNKTPVEVRATLSALEARVQQEVVAVFMGHLGLGGRAWERALWSRLDFNGYFSQHRTRPAVPVTLQSVSASANTFTQPRRTRARSAGRLSRPKSRATTPRHHQRTPRRTSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SGV6</accession>
    <name>A0A088SGV6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_321620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701847.1">
        <property type="nucleotide sequence ID" value="XM_010703545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SGV6"/>
    <dbReference type="GeneID" id="22577903"/>
    <dbReference type="KEGG" id="lpan:LPMP_321620"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320021800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_321620"/>
    <dbReference type="eggNOG" id="ENOG502SF9V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="263978at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="589" mass="65266" checksum="E23A64D0D4AAD9A7" modified="2014-11-26" version="1">MTLLEKDRSVRHEPQRTLPCTYGEEPDSGSLLQERRGIAPTSNRQLHEATQQYTKSHGVHVDNAARLAAEKEVPHTFRSRRPPMKEVHAKLFVLFIFGAFCTFVGFNVAHLPLPSARHDVAGSSLPTDKAALITLSNSHSEERFKFAKQIALTDVPYLMPWHEEEHLAMLFIWRLLYRSLKTDLDQFETHLRSISPVGTTVLGLGGSAKHELPKVIIEVVEAHAGYITTSLAHFLSTTYVFSVVTSAPTVQRYGRDGVRRGYTRGADSVYDSRKEDLAAERQAHALNVAAIVERVLANPAADRAVEGSYQPHSNALQPTLDGDIQRTSAKRTGNSGGSGEGSVAQGKTETATATWSSSHFCLCVPRHDLNFSYYINIAAQGLRVNYQVVLSPHITLRSARTVAEFDGALRALLTQANVASFIALPWLSKRNSAQTDRADNSESARQRSSLPEQELVDYESWYGDSRPTPLQVLQRTLRGPEVETQYTVLVVSLGSRWWSGAFRELFRVELKKKTQEQHLTNVTSRSTTFAPDSPRVTVKDVPAANDASDSVMFTPILLTPTTANMFDCTARQALLGCMERAVHGSCAHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SKE1</accession>
    <name>A0A088SKE1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_351500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703087.1">
        <property type="nucleotide sequence ID" value="XM_010704785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SKE1"/>
    <dbReference type="GeneID" id="22579179"/>
    <dbReference type="KEGG" id="lpan:LPMP_351500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350020800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_351500"/>
    <dbReference type="eggNOG" id="KOG0379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000182">
        <property type="entry name" value="Kelch_motif/Galactose_oxidase_-_central_domain_containing_protein_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23244:SF471">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23244">
        <property type="entry name" value="KELCH REPEAT DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="668"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="888"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="681"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="895"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="914"/>
            <end position="945"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1139" mass="124536" checksum="0316890D7AAF769D" modified="2014-11-26" version="1">MSRTLGLPTMLAPLPLSNLAASTPHSTNSCVMAPTTLTMVPSLSLENDFKRDTEDPNCQRSGGGVVGQDNHAPAVSTRSLIGVCGSVLPEKKGGLPKAGHIGVCYRQDLYVFGGVNSKGQFSNHVFCHEKRTLLWRETRGIGVVPRGRANHAGVLIGSKIYIHGGHRQLEVFDDLFAYEVETTRWEKIACERSQGPGPVFLHAMVYIPPLHSLLVLGGIHQREQNSWLGHLFDLRNRVWTGVPPPPSVSAQHLQLVTVAYHAPSAMVVVLGLMEMNVLEDNTAPTPHVHLFQPSTFLWRRVETRTAPESPLPFCMEDTWEPLLHILIPGGGGVYDPFLESWMFPLPSTVTDDTNDDDALGQRPSKASVVLPPVPQNKYGFLVLDLRRMSWSLVSCNVSRKLVAKLNAVNRVTREKMERIVMRNPAAAAALALAGSSSHSNSPVHQPVNGGSVLGLSRTSLDHGASGVATRRPSGFRHQPSQWQRHSSSSTSLPWARASATRTSMGSGNTDSKTAALLSASRYRRLFFFDDAPEFMRKYTLVAVRDEAAKSGRLRPLQYVVLHGGLTEPTDYAMLMFTPMVTWLDANGAVPAGGTCRKSRSDSLCGQGAANLGSWRGSACIQSFGASNDDYEDEDFDDDASLVCSGASTSARTSQRDYRSTVPYAPPREVEGLIHSRAGRDSDEDEDDVNGEEQLNSGGAMRRSFLLPTLQCGRTSRNYCRFALQFAPGNSVQKESLLPYLNIPVAVLQTPGDVQKWSRHYYTDQRRWLSGRLKDALLEDRKLRRLRQVNKARQAQMTTVSGAGASVSLAGSAAHEDESNDELESFMEGLYFMESLTGDPRTHSGANSSGLLANEDQLSLDAAAAAVTRAEAQKKRVCDFFEEHGLDVFDEDRDLQSPQGQTQMRTTPTKLSGNEAKHDGRQKDPRPKERTAVAEGANEKATKRSEASPLVPNSGAPDAFVPLVSESQMADPCFERLRTKVRQDGGRERMAVTLFHDLFINGLAGGAPGAALDFRNLAAYALLNGLMARLRADGDLHETHRRRAQLRWRFLRAVVRTGEAVYLLYLASQADFKMKGTVVTGTPSLLLAPDLYFVGPSQAYRVPCKPVPYNLAASSAPPLASSSRLAQMTASGMVVYHSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SLY3</accession>
    <name>A0A088SLY3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">T4 RNA ligase 1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_357050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703632.1">
        <property type="nucleotide sequence ID" value="XM_010705330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SLY3"/>
    <dbReference type="GeneID" id="22579733"/>
    <dbReference type="KEGG" id="lpan:LPMP_357050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350080200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_357050"/>
    <dbReference type="eggNOG" id="ENOG502QVSK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276239at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019039">
        <property type="entry name" value="T4-Rnl1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32004">
        <property type="entry name" value="TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32004:SF1">
        <property type="entry name" value="TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09511">
        <property type="entry name" value="RNA_lig_T4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T4 RNA ligase 1-like N-terminal" evidence="1">
        <location>
            <begin position="69"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="904" mass="99127" checksum="069B271EEC3C0BED" modified="2014-11-26" version="1">MEVLKRECWFYSEQATPHATKVDAATLDRYVARGRVTLATVTLSSGRDVSSVSVKGASQGDVKGLPCGARSLLIDHADGSIVCRGINKFFDLNEVGSDWLKDSSLWTNAYRVWAVRKMAGFIITLFSLDGTRLEVMSKHVLVGPHVDAAWELLERVSEAHRARMAADLFEWGACACCECIRRTQDCLHPVLEAEQFDEQVILIAVQRRTQLREESLCFSQLATVAERWGLDGAPGVAVTDDAALQSVFAATASWNAAYTPFDTCPQLAEGFVLLIETAGSAAALIPRWCFPLRLKLKTPKYVVLRAFRSLVCGDSRPQSYLYHQALMGWLQPRNAAEVRRRVAEAGVHVLNNEFESDLLMQQRVRHRDAQETIGDALARLQRTTALTACPRGRCPLTVVVLCGLPGAGKSTLSMALARVLVLEEVSPFSFVVHLSRDAVSRTVAVDHGITAESSKHKQRRLRALVHQTLCDQLREVACFSTETGQSGLLLLDACNATQESRHIWRQCFPTTLHHYEVAFVECSDTTVMTQRAARRDGHEVLLSVAEAQQALYAVRRKFQPPLEEAAWSVDTKVSSIEEAAASLRTHLEQRAPPRSCAGCCRTLTIPALRDERRQSHATLLHSLLGLSEGTSGALTNMMFYETSTPKVSRATSLQIRLDCSTEALRSAAAQLVSSSLAQPRQSAVSFASAGRLLFRRVSAALRGLSWAPSFPVTGHVTRGHLKWLRGWLLRGRDSCGPAEVHSALRERFVMEPASSHVTLLRINSSVGSTSAEQAVSEYLCQTGMRLGQEVAVRVTSLLLDRYAVSFGVTLAGGQHVQGPSVQRPGGTVIPLHITVGTAAGVAAAYAGNMFAMFDVLQAENESLEAVQRGSFQAVNRSQRKYHNFVEYQLNTALPLRGVVEVCPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4T2</accession>
    <name>A0AC62A4T2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3420390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="XUY36803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="738" mass="77305" checksum="CE8483584B8BBD08" modified="2026-01-28" version="1">MNSYRLEVAVKRVSGLNPLIASASSMIAVEVRFLNFPPIMIHPQGYAVGDTVTYNVCHKADFRMCSEQAAANFPAMCQCQLVSVNEGAVAGGARWSCPCLLVPQPGAAAQLSLRTYANYVISNAAGGAVGYADMSCRVLLQDPPSTAPVPISMPAPQASVTPLPVAAPPASALEPSRGTSADQGKPYIVRVVVGESDRHRRPSQATRWDGVQDTSRGHEVTVTRASASDRGQPSRCVSANTAEKGSLLHLLQYDVAYQLQSLSETVAAALHREHDVLTRTPLKGPDKSDALSTSRLTKSIDHHVASIVKVANIVLQVVNQLVDNSPATPRIGASRVVKDMARQMRNPVNKLPLPAEDSIGHYLQYDVLYQLQCLGTNLSYMTVAYRAVLDTPLSSIPVQHVAYCDELGHEIQHLTKQISILVQSCVDGTLSTAALSAAPRPVVQKKDQKQRKANSRSAPQAAAAHLGAHKLSGAAKSFSSTSYSSFSNSRGTSTSSLSSSCLSSSLNRPATPASQPRAPTIVAAPTNPLPAGQSSLAATPTPSAPAQPLPPPPSYATPAATTPRKQTSPSPPTPPPPYTVAAPPAEQTAMSLPTPVGSQMWLSPFNPMDSLGEPTALSQANPLVPRVSHINQANNFQLSTAAPPRDSLHPGSQSTTVYGMTASAFTPQPVLATGGPPALSPQHLSLVPPPLAAPTPLTPPSAAPSPPPMATSKLATPPPIQPQPPVPLTIPIPVPIPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A556</accession>
    <name>A0AC62A556_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3420560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="XUY36820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="426" mass="49418" checksum="9559EAD7F19D9C72" modified="2026-01-28" version="1">MMHFSGVVRRQMRPYYNLPSKSEHGRRMTGFLTPYRHWMWKQNELWRNVHEAQFEHLRKVYKRQWLESFRVNADEYIYKYNITKSAQLAQWEHEMQAQERKRRESQQLAQGRQALKKKHLDLLREFHERQFFYWYERASERLQYMARINYISQASIQEHIERELDKYTVGSKAPYPLNFAGQMPMLEDRDGNIAQVPANLMTNHATENPDGGATIYEPPEGTAVAEEKLLQMMASAQEEELRIRPEDGDAWSESMTDMDRSESARFDSRKVARSMEETDEEREVSRRAYIDRGKTGSKAIFRRPRFDGDGATSPSAGGTTPMKRRKSKTDRMHALQEQQDAAVAKATAKALKDEGSTAGATKRGEVAENRGRLRDRMITPSLETLQQSPEMMAQNKPGGRVRTHHLMEKVYGIGKFKKGGGGDEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5D8</accession>
    <name>A0AC62A5D8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha tubulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1320220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="XUY36993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="451" mass="49683" checksum="3D47FCCC1FBC5BF5" modified="2026-01-28" version="1">MREAICIHIGQAGCQVGNACWELFCLEHGIQPDGSMPSDKCIGVEDDAFNTFFSETGAGKHVPRSLFLDLEPTVVDEVRTGTYRQLFNPEQLVSGKEDAANNYARGHYTIGKEIVDLALDRIRKLADNCTGLQGFMVFHAVGGGTGSGLGALLLERLSVDYGKKSKLGYTVYPSPQVSTAVVEPYNCVLSTHSLLEHTDVATMLDNEAIYDLTRRSLDIERPSYTNVNRLIGQVVSSLTASLRFDGALNVDLTEFQTNLVPYPRIHFVLTSYAPVVSAEKAYHEQLSVADITNSVFEPAGMLTKCDPRHGKYMSCCLMYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKCGINYQPPTVVPGGDLAKVQRAVCMIANSTAIAEVFARIDHKFDLMYSKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGAESADDAGEEDVEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5E6</accession>
    <name>A0AC62A5E6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_262130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="XUY36911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2124" mass="221348" checksum="76B1DE28BCCBD738" modified="2026-01-28" version="1">MPPPQSSSPKGGCESQKAECALRGDAAVAAVPVRRLSSSSLRRARPTEAAETTAPSTLQVLRSPSRLLGQKRHVSGALQPRCDVDTALAVVRVGAARSVTNTGWFYPLRALERQRQTAADAYIPFTIVSAEAESSQRARLGLTTIAVDSGCCDGGGPDTLTTLPLLRSGPVGTLKLSGERRVPPPSVRQKPGVDAVVPGQDRFFTADRIRWTSLVAPEPPPHKFRIHAHRSRPCQSARSRYPATPIKGSRRGSTACPCTRDEGIDTLAVNVDAAFLTQSTPAPIPSLPVLPGAASSEAYAHSISVQYARLHRLIRGYRASDHHVTVASHVASGEAATVLTPEMATNTLSPRPPATTSAARLTFQPSVHSPRRSSVSLAAPPSFLLTTPGVQHACHSTVQVCRRPFFATLTPSTSRAIEAPLTGAHKAFSQFLTDQQQPQPHGDCPSTNSQRPIISPFAPTDASRGTPHYTRNDRAHFQRNCASTRNRHHHTLFQREQHQRTHIAANASHALNTLHGLHIRYRQYVESRLHPCTEPPAMASQRQAQQPFAPLNSPHVRHNIPQRHNTNPHIPTSLTQQTLYSAVHTATKEAAAPEALVLLEETSCTAAEEAAAPEALVLLEETSCTAAEEAAAPEALVLLEETSCTAAEEAAAPEALVLLEETSCTAAEEAAVPEALVLLEETSCTAAEEAAAPEALVLLEETSCTAAEEAAAPEALVLLEETSCTAAEEAAVPEALVLLEETSCTAAEEAAAPEALVLLEETSCTAAEEAAAPEALVLLEETSCSSSEEAAAPEALVLLEETSCTAAEEAAAPEALVLLEETSCTAAEEAAAPEALVLLEETSCSSSEEAAAPEALVLLEETSCTAAEEAAVPEALVLLEETSCSSSEEAAAPEALVLLEETSCTAAEEAAAPEALVLLEETSCSSSEEAAAPEALVLLEETSCTAAEEAAVPEALVLLEETSCSSSEEAAAPEALVLLEETSCTAAEEAAAPEALVLLEETSCSSSEEAAAPEALVLLEETSCTAAEEAAAPEALVLLEETSCTAAEEAAAPEALVLLEETSCTAAEEAAVPEALVLLEETSCTAAEEAAAPEALVLLEETSCTAAEEAAAPEALVLLEETSCTAAEEAAAPEALVLLEETSCTAAEEAAVPEALVLLEETSCTAAEEAAAPEALVLLEETSCTAAEEAAAPEALVLLEETSCTAAEEAAAPEALVLLEETSCTAAEEAAAPEALVLLEETSCTAAEEAAAPEALVLLEETSCTAAEEAAAPEALVLLEETSCTAAEEAAAPEALVLLEETSCTAAEEAAAPEALVLLEETSCTAAEEAAAPEALVLLEETSCTAAEEAAAPEALVLLEETSCTAAEEAAAPEALVLLEETSCTAAEEAAAPEALVLLEETSCTAAEEAAAPEALVLLEETSCTAAEEAAAPEALVLLEETSCSSSEEAAAPEALVLLEETSCSSSEEAAAPEALVLLEETSCTAAEEAAVPEALVLLEETSCTAAEEAAAPEALVLLEETSCTAAEEAAAPEALVLLEETSCTAAEEAAAPEALVLLEETSCTAAEEAAAPEALVLLEETSCTAAEEAAAPEALVLLEETSCSSSEEAAAPEALVLLEETSCTAAEEAAAPEALVLLEETSCTAAEEAAVPEALVLLEETSCTAAEEAAVPEALVLLEETSCTAAEEAAVAGAYETGDGESCNLGASVNGVCDKFCERSVWGGGFSVSWSCRADEEAGVVLCSYRCGVPEVAVDAVGRVVSVCAVFPDLSLSVCGEERVVGAVFSEFCGIRRGVVVDSEHVLRCPGWSGYLLAYASQLRELVIADVCATLDCAAVCVRNVHMYACAAGVATRDNDGVAQQSEDDVLRITVDVIQEATSALHPLGGVRPVIDGCRFPYLQQWRRSRDEWRLSGDGVLYDAGSSNSAVTMLFGSMKGDASDAGERGVVLPLWAYSVRDAAPISSRPSMVVRSRLAFPRVADLPEGRNSNACSFDLNWNVHHDRVLADLEKRDSADGLMESDLLQEVRMCQLTASMQGASRLSPMQPSRLTALQMATPFVTEEIMVQENGRAHGLLASRSSATPLMAPTETLRMVSRHTEMAASPKEARPETKRKGFLFWKRKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5H8</accession>
    <name>A0AC62A5H8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Paraflagellar rod protein 1D, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2920050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="XUY36940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="595" mass="69230" checksum="2A6C834CCF1D1D06" modified="2026-01-28" version="1">MMSPEDATGLEAARKQKIHNLKLKTACLENEELVQELHISDWSETQRQKLRGAHEKGEELLASVEVGTKWNLMEAYDLAKLMRVCGLEMSQRELYRPEDKPQFMDIIGVKKVLQDLRQNRNKTRVVSFTQLIDNSIAKMEKVEEELRRSQLDATQLAQVPTRTVKMMEDIMNTTQIQNALASTDDQMKTQLAQLEKTNEIQNVAMHDGEMQVAEEQVWTKVQLQERLIELLKDKFGLIGKCEEENSQFKEIYEVQKQANQETSQMKDAKRRLKQRCETDLKHIQDSIQKADLEDAEATKRYTGNKERSERAIKENEEMQEETWNRIQDLERQLQRLGTDRFDEVKRRIEEVDREEKRRVENAQFLEIAAQHKKLLELTVYNCDLAMRCTGLVEELVSEGCASVKSRYDKTNQDLAALRLEVHKEHLEYFRMLYLTLGSLIYKKEKRLEEIDRNIRLAHIQLEFCVETFDPNAKKHADMKKELYKLRQGVEEELAMLKEKQAAALDDFKESEEALDAAGIEFSHPVDENNEEVLTRRSKMVEYKSHLTKQEEVRIAAEREEIKRARLLRSGGESAAAQITSGSLRADNAANAQLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5L2</accession>
    <name>A0AC62A5L2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histone H3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1620160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="XUY37027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="66" mass="7238" checksum="D87F239EB5F19D1A" modified="2026-01-28" version="1">MPCARCRACRRRGGPALPEQRDPGDPGGVRCVADGCHEPGQHPREACVTVRPKDVQLAVRLRGERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5P2</accession>
    <name>A0AC62A5P2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphatidic acid phosphatase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1820020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="XUY37113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="497" mass="54127" checksum="27CD5B71C199D756" modified="2026-01-28" version="1">MACPRMSPIGLLLPLALYFSSFRGTRVHSDLVYLHPPGASRHRSAPLPALSHAPHSVAHAHAQSSPNPLLLESGPCSATRRSAIPPSTASLPHPSLTRRQRAKRAKMGLLRLNEVLRFIFFFRLHDYLLCILCGLIAFGVGRVRPYCREFSWTDLSINFPFSKSPAFPTWTLFIISAAPLVVYVLGEAMRHCWLARRHGGILAYEPYAEHTLILMGSQRHGGDGAEMSMKADGNGSDFEAPPLALSSDSSKPQNLASGREPTQEVQVGSETAAVAPACHLSASPPPEKLCGSRGDDGRSSGAVAVSLAHAANSATQPQAVHLYTLAHPWQRFLLYTHMWVLLQAFSVALSVIIVNALKVYAGRLRPDFLSRLRNEGFNASSMGVDWCTVANEGRLSFPSGHSSAGFSAFVPLCFYVLHSLHAFRLSGVSLWRILIGLTPLILPITVAVSRTRDNRHNFDDILAGSLIGIFTALVAVRATMMVNYGTGQLTPRFAYYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5U0</accession>
    <name>A0AC62A5U0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tuzin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2020170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="596" mass="65513" checksum="3A48FD4679A59D00" modified="2026-01-28" version="1">MLGPATRCCLLTAVRRSVFAQPGLEGLRIAAYAPAEPGVPPSPRRLPVAVGRVVAQLSPLVFAVDFRDSPPPPAVSLGSRVYVAYEREGAAPLPQQGGGVVDDAPGRGFLMGGFVVRVNLNGTLGVLLESNRVDLGVPPERIAVTEGVCNFVRHPGDLQVAEWVRSAGLSGADEVEGTACMLYHRGWRAERLHLLEASGTHCMAHLSQRSRMSLMEKAEWQRDHHRQMRSLYSERVKERDRRYMAAKYAGILSASVAFCGALSLFGWNYRNHLTHQRTSQMRFAVRTLCKEAPPGASTTADAAHQLSRQTRREALERWIRPVFQQLDTAHPRIAVITGSFGCGKSSLCRAAMREDGMTGVVVDVRVREDPLRSVVMTLGVPHVEACGDALDFISEACCRAKSMMGGKTPVSVLGLREADSLARVYNEALALACERRVCHVVVEVPLEALTVTSTLLPRLDFYTVPNFSRSQAHEYIQHRLDALDTEAFLDTVGTSRADLDELLAAAHQRRVSPAEYTSERLLRAMRQLQAAWGDDAQLKTAVKRLAQRPYGEGRHVGLDGSSLSHPSLRDVVLYNPVQDAWHFRSRVLHTAAACLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5Z1</accession>
    <name>A0AC62A5Z1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribonucleoprotein p18, mitochondrial, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1520020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="XUY37006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="187" mass="21333" checksum="9940DD9EF80F44EE" modified="2026-01-28" version="1">MRRLSSQLICTAAAARFASAGGAKKYDLFGYEVDTNTAPWIEKVKKCQYYDEAGEVLVSMNVKNCPPDLETYNATLQKIFEAPSKQDKPVDNESKFCAMMDLMEEMQHRNKVKPNEESWTWVMKECVKSGQFRLGYCIARLMESEFKRTPEDLVKQNEANAMKAKADGKEHPSALAQQQSLFEIKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6D9</accession>
    <name>A0AC62A6D9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Folate/biopterin transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1020060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="XUY37359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="699" mass="76021" checksum="B38EFD495ADB1A08" modified="2026-01-28" version="1">MLLMDPAESRKSHVTPDTEAAAAAVPVATVTENSGKYIHPEAASLFATCSWLRRVPIFGEAVEGYGPKVIVALGGCYLMCKGIADQILYGQTYAMMIDRYGIDVARYQRLSPISTMGWSIKAFTAMLCDGFAFLGYTKRWYMFVSCVAGGAFALIYGLLPAKESSANIACAFIFLSSWGKANVDILSQGHYSRLMRQNPQPGPAMVSWIWFWIMAGSLIGTIMNGPLADAGKPQISIFVSAALQLATCVFYVFNWYGEKKNRVLRSEDVLYLLEETRRERARLGLEAGTDGQAGAAAKGKRSPQHSHSDEDVDAAVPGGLHDSRALVQDDYYDDDSEAVADGEVYYGKPPVPCLLGLFEVNTEVISKNWRIFVYSAVMTCAVIAMLCANILADTLGLLMACVVVSTICCATSFWALPLVIAKANVFGYLDKAVTIRVSSPINAFYLNSYNCPGNLPNFSYSFYNTVAIAISSVVGMITVALFNFLFAKHSYRLTFIVTTIMQVLAGVFDIIMVKRWNLYIGIPDHAMYLWGDAVVGELVYMLALMPMIVLVSRLCPRGSESVVYALMGGFSSFGQVTAESLGAILMEYALPVFKMQDDGSRCNFDNLPVLLFVCNMCTPLLAIPLSMALLPKARICDDIDVDGRVVRQIVDRQAAAAGLCDSDSEKVAAAESSRDGKRGDGGAGHTEGEQSVHVRTPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6E5</accession>
    <name>A0AC62A6E5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histone H3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1020490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="XUY37383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="130" mass="14775" checksum="3B7AC1682C1CB152" modified="2026-01-28" version="1">MSRTKETARTKRSITAKKSKKAPSAVSGLKKVHRRWRPGTCAIREIRRYQKSTELLMQCAPFQRLVREVSSAQKEGLRFQSSAILAIQEATESYIVSLLADTNLACIHAKRVTIQPKDVQLAMRLRGDRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RH65</accession>
    <name>A0A088RH65_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_030820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009372">
        <property type="protein sequence ID" value="AIN95317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701025.1">
        <property type="nucleotide sequence ID" value="XM_010702723.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22571948"/>
    <dbReference type="KEGG" id="lpan:LPMP_030820"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_030012900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_030820"/>
    <dbReference type="eggNOG" id="KOG0531">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266138at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001344">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF70">
        <property type="entry name" value="LEUCINE-RICH REPEAT PROTEIN (LRRP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="168"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="292"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="345"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="838"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="910"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1079"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1138"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="256"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="318"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="838"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="910"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="972"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1097"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1166"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1203"/>
            <end position="1215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN95317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1394" mass="149971" checksum="63FD28540A5D6BA3" modified="2014-11-26" version="1">MSAHAEFAERLEALFITELRRQGVADTEGWAAKLNTYCSYVPATSADDRSRGAGDQQRTSPSIVLVIDMTNLEVGDKPVVALCEALLRMEGPSLRGRYANVSEWQVLWRRCGLTDRALRHIELLLLGCQRLTLLDVSANTLSPAGQASLLHAAAEVPCDVVIAEDARATHSGSRTREASVPSSSLCTSHPPELVEHQPQNQASRHHRRSGGDVDEARDASVASRGASQQQHRSGMRQQTTPPSGHAAAAEPLRQRSSSFSGASASASPSLRSYASGSAEALQKRREELFGRFTTATQPSAAIDPAESAASARDAPAPVGGGDTQKGGSGGITAANNDVVEFEAAKATTEDSPARPSPAAAQQPHLEWRPGEERTSGNVSHSPFVAAPDPKERKPPPPTHRTRGMKAANTPAMTAAASREPFADRNDQIDLTANLNPALDCALDLSALMTRDGALRQVRMFGGARSVWDVLEAYERAAEQQMHGSVSHGGEACVDAATRAKLPSALLGGATYSVITVLNLSRNHLTTLCALPAALLRLDVSVNDLTELSGVQNCKMLTVLNARRNRLRAIRGLEKNRSIAHLFLGHNGITAVEGVAHLVLLETLDLTFNELRTQASLRMLSLCSALRHLLLRGNPIIESGKPGFMAVLRNLCPTLLVVDEYRMVNSCLADRALAQRNWGRQPNMIDNTQPYARTETLRGVNSVGASSSLLSHTAITGGSPSADGSTMSSVAFTSSRRREGSRPAPFAVGDDDVADERSMNLLHMLTRGVSAPTGYGDSVRSQHAAQQLAQTRREKEAQAQMERERRLTANGRQLRGVVVKQLAEESRKYLEDTIVRRMTTAQQQQPQGSHSTLPSAGGSGIDAAGAPTSDLMARRASVELNAYGGVAHPELMDNPLADVVVYTAALPEKRQRATMEGNTRDKTDAELLRRYKPRSAQLRRDPSANQPQSLAMKASAGAPSRRHPQVPQRRAVSAGHAPSPAAHGGGARHSSAGTTRRQSARRAHRDDDDAALATLYAGDASEPLPGGTARSGSGSYAALHVAEQSQLRSLGDAELECSPISKDPQARLVRSLNTTASILHDSSHLHRMSDPPNSAHLRSPSPTTQRRPSPTAQARRHPTPQNYRDPAEVEVTAIYPSSHSQRCSLPGGGGDTQKAQLQHYKRTPSRANAPASKSSSQSRSTSASAAASRVARSDSVGGREVQCSAAGPSVVSSVGTSDPVLRPIHIDDAQRARVKVWTQQLRDDTDALQDALQTLVDLLGAQRQPHMSVPESSRELPPTYLQERQRCIQIIQESGMLQDTYVPMDVIVYYGFSKAELEGEKDRSAQVVTRCGGSTEADERAWAREVAERSDVLRQLHLMGDAKTCLRYVALLVSDGREKLLQQYVDQLREGLRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RI18</accession>
    <name>A0A088RI18_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_051020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="AIN95543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703865.1">
        <property type="nucleotide sequence ID" value="XM_010705563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RI18"/>
    <dbReference type="GeneID" id="22572180"/>
    <dbReference type="KEGG" id="lpan:LPMP_051020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000033000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_051020"/>
    <dbReference type="eggNOG" id="ENOG502QRNZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262874at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048870">
        <property type="term" value="P:cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056290">
        <property type="entry name" value="CEPT76/DRC7_peptidase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033551">
        <property type="entry name" value="DRC7/lobo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056292">
        <property type="entry name" value="DRC7_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056291">
        <property type="entry name" value="MORN_DRC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35249">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35249:SF2">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24656">
        <property type="entry name" value="CEPT76_peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24671">
        <property type="entry name" value="DRC7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24667">
        <property type="entry name" value="MORN_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CEP76/DRC7 peptidase-like" evidence="5">
        <location>
            <begin position="184"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein regulatory complex subunit 7 MORN" evidence="6">
        <location>
            <begin position="424"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein regulatory complex subunit 7 C-terminal" evidence="7">
        <location>
            <begin position="734"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="387"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="398"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN95543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="847" mass="96537" checksum="2A260115DD7D645E" modified="2014-11-26" version="1">MICSFVRPTLLPYDQLFDLEGSCQFVADYVRYEPLYDPSVYDDEYDSTVEQLPQQIVSPATALDWQVGNCFEISLVLISLLIGAGFNAYIVVGTATKAVCLSDQKSTMWDGELPKEVNSDDEVEDDMPKNNPYMALIPEKLTLRLTTDPDPTPVSRMDSVMMNPDNYPKVTGTPNVRGGTVKPIHSWVLVLPGGRRCVSKAVFVEPSTGKLIPFSATDNRYTSVEALFNHHDYYVNMRPEAPVSSLSPDLADRNQWESLFSYANPSGDEVEGLAGTLSATRRAFTNDLAATMTTATMNMTEASDSRCRRMYIPNLWSNELILSRQQYESRYPGGYKEIMYVNAVVRSYAPYSQSDYRTLEVVVPDAEYAELHETHVFYAHRADKLRRATASPSPTPQSPSKESSILPSHSSLSLTKAPTGPRRMVKWYEKGRMHNTTVEGLRELIYEPGKQRTMKFYWRARSDGLYCRTELLYDANTVRKVKEFYKGRTDRLWYRSFSYGRPSTMREKNMHSLIVHGSKSGSTLREYPRLDPVRVSQKFQRDERVSASKDVAKTTFLRPASEGKSGGSNNTPSVGEMWVFFHYDAGSILRPYHMFAKPSSSVEEYIAASAAGKPVEPPVRVVSLPGEGPPSELDLYNERKWLSAGEATCLMEHRAKLDECMDILNTIEQDYKVQPVISVYDTLRNRPKETEAERARKLAEAARREESRKDYLAPYIAKLEMPADFDGNYLSVRLSVVQAKQVRDEALQELKERLIQRGHIMQSRMDKEKEEFNKRQQLYRKNCDASALEGDRDTEAFALYCKEATWRMKVLDDRLLQHIDYASEKYNQLARRLAEDSRLSALYHPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIR7</accession>
    <name>A0A088RIR7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_060960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703977.1">
        <property type="nucleotide sequence ID" value="XM_010705675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIR7"/>
    <dbReference type="GeneID" id="22572302"/>
    <dbReference type="KEGG" id="lpan:LPMP_060960"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060015800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_060960"/>
    <dbReference type="eggNOG" id="ENOG502RX90">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="394"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="203"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="436"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="787"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="957"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="884"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="957"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="967"/>
            <end position="979"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN95655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1222" mass="132947" checksum="3714C3E91CC206E5" modified="2014-11-26" version="1">MHATGMRSSVSANPSRTARPSKTGASISPSRTALSRGASPAMLAAVHRERGRSTSPSTQKKARLGAADDVATVVSGSATVTPTTGHGTASTASPSVTGVSPSYFAQDGRRFEPNTYETTFNFRGQYEHIVVAHGTATLWCANTASGAIDLYSCVTGQFVTSLRPLHEEVAARQVELSELPLNTSCRKATSGGAKGTASGLLTSHCGTAAPTPRSRGLVSTRGGRRLSGPSSAGGAAHPHESAPNRASASSPVSMWLRVPEGSVRATALCATATHVWVGYTNGFVAVYDALLLKLITFGQFHTERVVSIVELCNMQIVSASASGLLILWDTEQGGFEAVTRVTVLLDSVREGAGALCAMTSVPPTARVCCGFESGVVYSVLVASRPQGQTTPQELRGHQGRVNAMAVVRDVLFTASEDSTVCVWHRGGTACARGAESLRDKGRRGPVSSNHLREATHDGGQACGGLHTGGPMKMLKRITVSPCVRSLLAEEQTCSLWVAYADGLMERWSANPDDDYGVEEVVEGALTTSQSAGNGGVRALLSLSVVQTMQWLALSSNGVNKVWYGHQNTLEIDLANSISTLAQVVEQDTEDAAAWRERVNLLKQKEAERREKYVCILEQLSEQRVLLRHYDMWKRSVLFVGARRKRVEAVAHTLEKKSHLQLIRRFFGKWASFYDAQQRHIRAYVLSMALSRATEQLQLQAYFLRWQSYLVYRQVQQKAVEGVHVLARLVNAAVIGSYFHRWRAAAATTIRRQRSCISAEQLALLASKAQRQVLQRVLRQWVSHTDAQRRSKQNASEAAAAAATSQDGLPVPGTSSLARFAAHYAQIQQQQHGRRVLQLWRRWTERRARQASLAAVAALREQQLSYETGQRFFLRWRQRVHARHMGENMEQLKVLEMELRRAEAEHGDIFEKLQLQRQLDLVLERHAAEEARLAHIKDQLASAEQTCSELRARQRTQSVISSNSVAGASSRDSSLAPSSGAATGASAAVALADASPRSSIVRLAGTDTELSLSTTSESPPLTQLQSQPQQVVLSTMSRGHMASNAAWYRAMVDQQRLSPIVLAHMPTEEAVHHVMGQLKGNVVNLYTDLALFRQVKDRRRAGTSAVGILLEAFGEVKRLIVITVRGASANAASAAAARMGGKATRWPLSMEALDCIPVHHCATVLSAIKTLVVAYDLLQSEDMANVQTTCEEVVVNADWIFLIARACYLRRKPAPPVNNRQLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIU3</accession>
    <name>A0A088RIU3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_070090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009376">
        <property type="protein sequence ID" value="AIN95695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704017.1">
        <property type="nucleotide sequence ID" value="XM_010705715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIU3"/>
    <dbReference type="GeneID" id="22572344"/>
    <dbReference type="KEGG" id="lpan:LPMP_070090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_070005700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_070090"/>
    <dbReference type="eggNOG" id="ENOG502RYIE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269892at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="191" mass="22416" checksum="49F45D7FF3D2671C" modified="2014-11-26" version="1">MLQRSCTSRMLACTTALLKRSGKPGDLPDYKQAYLPYDIVPTKMELDRERRKFMHAYSGRMEHRKMVEVKDVPQNMYTYGKEGMSIPISIFKDQTDPVIGPEWTYPGIFENKIVSQHWYMEELFDREKSNTFESPWQRQVLDNQVKRRLGKVAWRMSMLNIKTIDIFHKERGPSKRPGAADVKAPQLAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJJ3</accession>
    <name>A0A088RJJ3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="10">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_040010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 10">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="10"/>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="AIN95329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703651.1">
        <property type="nucleotide sequence ID" value="XM_010705349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJJ3"/>
    <dbReference type="GeneID" id="22571960"/>
    <dbReference type="KEGG" id="lpan:LPMP_040010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040005600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_040010"/>
    <dbReference type="eggNOG" id="KOG0202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000163">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000037">
        <property type="entry name" value="Calcium-transporting ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000065">
        <property type="entry name" value="Sarcoplasmic/endoplasmic reticulum calcium ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000160">
        <property type="entry name" value="Sarcoplasmic/endoplasmic reticulum calcium ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000083">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005782">
        <property type="entry name" value="P-type_ATPase_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01116">
        <property type="entry name" value="ATPase-IIA1_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="761"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="834"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="926"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="11">
        <location>
            <begin position="9"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN95329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1025" mass="111544" checksum="637B2CDD960EC0A0" modified="2014-11-26" version="1">MAKLLLPDNPASMDGGLICSLLEVKEACGLDKDEAGRRLQVFGKNAFPVEASTPLWKLVVGQFEDTLVRILLLAAFVSFCMAVLEDNRVDFVEPFIILLILTLNAIVGIWQEDRAEKAIESLKELAPDTAAVVRDGVTQTILAENLVPGDIVEVAVGDRVAADIRLLTLESTALRVDQSILNGESVEAVKQVKSVCSKRDRFPSSMVYRGTAVVYGKARGVVVRTGTSTEMGCIECSVRKQEERKTPLQLKLDEFGALLSTTIGYICLFVFVVNLLRWFKTHTPTTEESWFECYIQPTVHSLKLAVALAVAAIPEGLPAVVTTCLALGARKMAGHNAFVRDLPSVETLGRCTVICSDKTGTLTTNMMSVSEVVTMEASGTTREYSIADSRLNIVAAAVSRNGAPAGDVLGDDAALDMVATIAILCNDASLMCNKLSAEVEKVGDATEAALLAMSEKLYHSAAQNGVDGPHLPVDRCRSLKKHLWFKERTLEFTRSRKSMSVCCTSVADARVHSLFLKGAPEEVLKRCTRIMCKDGRIVPLTPKILSTVTTKVNRMSGMEDALRCIAFAFCPIPDPKQLDLSDPAKFEAIETDLTFVGVCGMLDPPRREVTEAITKCHTAGIRVIVITGDKKETAEAVCRRIGLMPCEPREGLSFTGYELDQMTPAQKRAAVRNAVLFSRTDPSHKMQLVNLLQEQKFICAMTGDGVNDSPALKKADIGIAMGSGTEVAKAASKMVLADDNFATVVKAVREGRTIFNNTKQFIRYLISSNIGEVACVLATGLFGLPEALSPIQLLWVNLVTDGLPATALGLNAADPDIMEQAPRRVDEPIVDGWLFFRYMVVGVYVGLATVAGFIWWFLTNGFTLADLASFTTCTNRSNAKCAVLANPQTARAIALSILVVVEMLNALNALSENQSLVVIRPSTNKWLVVAICSSIALHLTIMYIPFFARLFGITPLGVDADVVASADLWDVLVPTDFTDWKTVLVLSTPVIFIDELLKFFSRCSNHHREKCSAEQVVGRMNHGWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJS7</accession>
    <name>A0A088RJS7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein BOP1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_110410</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat BOP1/ERB1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696890.1">
        <property type="nucleotide sequence ID" value="XM_010698588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJS7"/>
    <dbReference type="GeneID" id="22572906"/>
    <dbReference type="KEGG" id="lpan:LPMP_110410"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_110006500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_110410"/>
    <dbReference type="eggNOG" id="KOG0650">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5571054at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03027">
        <property type="entry name" value="BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028598">
        <property type="entry name" value="BOP1/Erb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012953">
        <property type="entry name" value="BOP1_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1 BLOCK OF PROLIFERATION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08145">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01035">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BOP1 N-terminal" evidence="8">
        <location>
            <begin position="98"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="369"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="716"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN96237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="749" mass="85019" checksum="68B0C2ECFEEBF655" modified="2014-11-26" version="1">MLPGYTAESKDDAHGYERLHDIILQDSDADGEDGRADEDDVILFPHAEELANAAVGINGDDGNGRVVRLGTTQHLDESDSSEDEATLNRVGDIPLEWYKDEKHIGYDIEGKKLMKTERSALERLLEATDDPNAMRTIYDALHDEKKTLSNADLQLIFNLQRNRTTNSNYDMYSGVQEDTVVFDPLNHPLARSSGPSKKAFVPALHDTKVIAKMVRRLRKEEAESKLRPATEEKEDEDQLLWDDGHVEMDTHTHFKYFNRVPKPKVPPPGTFESYRPPPEYLPSERAKQRQARLRTIDRREHFLPQSFDALRHVPFYHHTIQDRYQRCLDLAFFPRAQRTRLVVDPDKLLPELPNPKDLRPYPEKLSFHYKGHTATVRSVSVSPNGQYLATGCDDHLVRVYEVQTGRLMKRYDMGAPVQQVEFCPSKSLNILAAAVEYSLVFVVPTFAAHALVNDHTIRFLRAPGLSAGQQEAAHALGAVDTLGGRAVTQTTLDADETAHEATTDLHDVEEREKRAEFLDASAKERNAGIVVKIAMHAKVKKFCFHIKGDYLCALCPKDHVKYRQTIMLQLSKRKVFCPFRKFSEVVTDCRFHPREPLFFLATTNSVRCYNLMAHRLQRRFKASGGVTTCLSIHPEGDNFLVGDTTSHTSWFDMDFSDKPYKRMRSHKGVVNALAFHPKTGAYPLFATGASDGQVHVFHGMVYDDYNKNALVVPVKILKHQRSVYAVAWHPSLAWLFTSTEDGVVTAWTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RK11</accession>
    <name>A0A088RK11_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_110370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696886.1">
        <property type="nucleotide sequence ID" value="XM_010698584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RK11"/>
    <dbReference type="GeneID" id="22572902"/>
    <dbReference type="KEGG" id="lpan:LPMP_110370"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_110006100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_110370"/>
    <dbReference type="eggNOG" id="ENOG502S01G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273531at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="595"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="173"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="397"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="489"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="100"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="214"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="502"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN96233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="616" mass="68377" checksum="57A39DECBD4BEF70" modified="2014-11-26" version="1">MDKWKDAVTTQLNDAACKNKRLREELRLLREEKESALNELRVQLTEEFHERTAMQQDELATLKQQTAALREEKKMMAATHEEELQTTRMKLREMIQLELKTEYKRREEHWEKEKTQLQARMSAKETERAQAEHECDVLKLRLNRLGTQYDELATLFQPESGVTSLTHGLEAGDYKASGTGPENAPLTPAGAPGAGSATLSTNGSSAVRQQAAVAATHAKQLESIKAELQSKEQHAQFLLDRAKQEREAEKTQLLREQQLREEELKVAHTLLKQVQMENSRYMERILHAQTERQALEQRYAAKVSALSQELAERIRAADETQIVNKHLQEQLRTSQQQVATLEEESTMREEAFHALMFSEDNKQAAMDLQRAVQAARDEAEEWKMQYYASVTGSHSPTATAAAASQPGPSLPKSAGADDAHGSAAVSASAEAFARTPQAWHDQLAAREANLNSQEAQLARKAALLAAAEAKLNKMRSSMANQASLLLQQSKSSGRDGGSSDVGDPHGRRGDSDSRVFIGGDDRGSLMDDDKDRDLSDVPPLIFTAASLLPSALHGSLRLLEAQRRRLHLPGKCDLYACCFSGGVTTGAPRRLRRNALLITVMVFMLLLMLASLSAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RK80</accession>
    <name>A0A088RK80_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SNF2/RAD54 related DNA helicase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_110050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696853.1">
        <property type="nucleotide sequence ID" value="XM_010698551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RK80"/>
    <dbReference type="GeneID" id="22572870"/>
    <dbReference type="KEGG" id="lpan:LPMP_110050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190007600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_110050"/>
    <dbReference type="eggNOG" id="KOG1000">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2801544at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18010">
        <property type="entry name" value="DEXHc_HARP_SMARCAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002711">
        <property type="entry name" value="HNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45766:SF3">
        <property type="entry name" value="DNA ANNEALING HELICASE AND ENDONUCLEASE ZRANB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45766">
        <property type="entry name" value="DNA ANNEALING HELICASE AND ENDONUCLEASE ZRANB3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01844">
        <property type="entry name" value="HNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="192"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="450"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN96200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="958" mass="107344" checksum="E5EFA3D87C8AEEC1" modified="2014-11-26" version="1">MEALLPIETCLRCGYPYVFRLSRFGCVFSCACDECVDVLKVAAAFTAALRGRTVAVPFVPLMSSPLLELTCSMKVVVVEIDFLQDLVYTHFLNFHDADVAQVMVSLSLALREQLAFSRTALTGPAALMDQLTEELLVSAQDPALPFFVNPPPPGLREAVSDILSRTVPETVLDRIPHLLRRTMKAHQEEGVRTALRWGGRILFADDMGVGKTMQALATVAALEAYPLLIVCPSAVKLMWADLIEQYLHEQVSVDEIHLIHGANDALSIDVQPKVVLVSFHMATVLEKQLRSRSWKCLLCDESHLLRTNISGVDAAYTRVVVAIGKRTPHCLLLSGTPVTDTPFDLFNQIDTLRPSLLGKSRFEFAMRYCRLTLSPYLQIGESTRRMELSSLLRSCCMLRRLKEDVLELPRKSRVVMRVAHRLLPHRRERRSGDTSYQERYANSWKENWSGITEAVEHCCSKYDRVVLLAHHIGLIDALVQWTRDHRKHAVRIDGRVPVQQRGDLLDAFHRGEARIAIIGITACAVGISLAPAQCAVFCELPPDAAWMRQAEDRLHRPGQRDEVVVYYLLGLHSQFDADLFSRLCSNLSEAEGSRGTSLLLSQMDHVSHPTRHPKPVSYTPAHDSVQPTMEPLLFCVSKNTGRIHVRASEPTGFYTTFPWHEAKQCARQRQDPVWQQLDTFLDSVTRLSPFCRRQLVLCQAWLPPVFQWKSDCAAVSNPRRRNRYSKTLPVGWGVWWKVRRLYFPACYYFGPLIAAANNEYEAGCLSCAASLPQLDRSVYSLVPGSICCATSSDSELFCSGRCRVSFIIRRSGGAMRRSVAGVDKGVCSHCHVDCETLCTSVAAVTGRRERVAAIGRLHPQLLQFPTFCERIVSNPIPGNFWHADHVVPVACGGGEATLDNLQTLCVVCHALKTQEDMKQVRQQRVVLPVQELMARTTVDVAWVKVTASSVSRVTKRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RK85</accession>
    <name>A0A088RK85_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_120050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009381">
        <property type="protein sequence ID" value="AIN96333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696986.1">
        <property type="nucleotide sequence ID" value="XM_010698684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RK85"/>
    <dbReference type="GeneID" id="22573011"/>
    <dbReference type="KEGG" id="lpan:LPMP_120050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_120005400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_120050"/>
    <dbReference type="eggNOG" id="ENOG502SAE8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269325at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN96333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="107" mass="12123" checksum="88820DA6CCEF6394" modified="2014-11-26" version="1">MPKRDKRRTALVQHNFDSLKRFYAISPFVAAERAALPPVYSGVYSRRAAMNCYHIVGSSREQIVSDAMRTFTPSTCTTEVMELYLEVAALVSLYFDTKEQLLALPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKB4</accession>
    <name>A0A088RKB4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UTP23 sensor motif region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_120450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009381">
        <property type="protein sequence ID" value="AIN96373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697026.1">
        <property type="nucleotide sequence ID" value="XM_010698724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKB4"/>
    <dbReference type="GeneID" id="22573051"/>
    <dbReference type="KEGG" id="lpan:LPMP_120450"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_120009400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_120450"/>
    <dbReference type="eggNOG" id="ENOG502S7UX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="246482at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057776">
        <property type="entry name" value="UTP23_sensor"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24779">
        <property type="entry name" value="UTP23_sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001838993" description="UTP23 sensor motif region domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="UTP23 sensor motif region" evidence="3">
        <location>
            <begin position="701"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="673"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN96373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="726" mass="77526" checksum="349FC8A88EE7C56E" modified="2014-11-26" version="1">MTIGAMMSLLRLLRLCPPNLSGLRPLATPPLFLSFSVCHARPHTSLAPIHTYERSPLVAGGPAGTTHVKSNHTMKRRVLRAHANKRCLRILSASNLIQTSSGALSSAASRERGYAVLCDASFLRAVLLSYWQANAPAVWREARRRKLHRAAVTTNAAKSARSSVPQEPSAPPTADKIVEATAASIARLPFGDLPALSPHAFLAALLRDAFHGEGGSPPVSSNAAAAAVSTTPHADAASASKFHCYCLPETVAALHRMRDCATTSTASATTLANPSLPNSSVVDASLVTRQEKSVAGSKPQRSFISLPSTGSPRSAQRCQMTSTETWLAASFGDLATTGDGNGGGSGVAAHRHVGSSPSSAVFPLIFQEVPAAVVNHLLSRITLIQSEEQQQPRHTVAGNSREASWLGEKASSASLPTRNESKAIGEFMAANDTRLGRRPRESIDAAVDVEASACDLNALRLVSMPLFSDHNCMTYSPQSAAAKRRRQNKNRRAVDGSNDVSESPSLTVGHAPLARSQEARENNANASLSPSRPFSPRMFFVATQSHDVRRRLAAVTPLLRLTTSPDALWIEQRGTAYHYGEDGAEARRQRRGNRAVSSCPSSPAVAAAPYSRIGWRNSELVSSRFSSLSHTPSAPHAAATTTTVVAAAPQLSRADVAFMKHLGTAAEVPLPEKFSHHLHPPPQRASPESGNGVSSRVPADRKRRRQKGQNPLSMKKKQRREVFRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKM0</accession>
    <name>A0A088RKM0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kinesin, putative</fullName>
            <ecNumber evidence="4">5.6.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_130590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.3" evidence="4"/>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697141.1">
        <property type="nucleotide sequence ID" value="XM_010698839.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22573169"/>
    <dbReference type="KEGG" id="lpan:LPMP_130590"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130010100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_130590"/>
    <dbReference type="eggNOG" id="ENOG502SM70">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="123929at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115:SF1016">
        <property type="entry name" value="KINESIN FAMILY MEMBER 19A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="KINESIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="3">
        <location>
            <begin position="625"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="159"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="249"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="310"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="415"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="334"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="348"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="438"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="741"/>
            <end position="748"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN96488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1356" mass="144768" checksum="112DC2BDABEDB0F7" modified="2014-11-26" version="1">MLSHTSSSAPDRAAYQGDIYVVDAARGDHYHITVALRGPFHPMTSVTHRALQCTVRNLLLASPNTDTGDSAAQLRPLLLLRDGVPLDYSDVVTLPNGAVVEVHHGSADSLHHSSSSSSLFSSVALPSEQEMPLHSSSAIGATRAHQSALKAVNRGLDEEEKLSLTQSTATATAVPSPSRRLPPRRTRGASSNSSFVRGGDDTTDTCDSASQHTLAPTCGAATSTEPRPRGAAILSASPEDHAVSRQLILSSPPPATAPSVPSRRDSASVSTRSPGGETIFSIEQMPSLGTVNDRQPSLYERIGTYSFIDERSRVPQSDTAVREETPSAAGARATFSTSSTSLPHPSTVFTSPAFSQSSSAATEESLSPGASRASAAATDRPSSTPPHPSRAAPSAELSPALSTSVFVPAALPDAAASDRGTRAEPPSALSEPLTEHSQLQTSAPLPSPLPLELTAQTTYDRQRSSIAAAAAAEQRRLLTRLQQHTQVLQREKKALLTARLGGLRAQESADRLRALREAQEEAAAAEVDAVRARLGEHRDDLLSCWLRVLHFHDTHYPMPSALLRELEEEGDSLTLQCLSSIANYHTQKARLQTLQQQHMLKEAEVARLRWDAHVRRCRAEEMNGCLRVVARLRPPSRRPWLPASVLASAEAREHDGGYAVRVLAGSSVVAHGSQQINKPAPCRVVEVTDPSRDLRRRYALWAAYDAAAAAGSQQRLFEDQLQPLLEHMCRTGQHVAVLAFGAVGSGKTFALFGRRAGQLPPQSRRASGESAGAGALGGFDFSFGGGGGVDRAPAGITAVGVPECRGITHCLDPADAAREARVLESLTETEAVMQRQRSAERRAREERAWREWTGIEEEDGLLPRAVAWLTAHLRSESPHGKAGGPVVESIVFSMYEVYNDHVYDLLPTPPPRVADTTKPGGKASSHAMGPRWNAGWLPAPHIKNNNPEQLTELQLELVPPSTDGRSAGSDVPGTVLQFQQQSAQPQWRVKASEMEVRSATEALQAIQLGLCRRRTAATLRGAHSSRSHLFLCFRVKMQRPVIPAMASSVAMQWTSATAVVSGRETAGIGAPTSNAVASAGATGVAGRPKGYDFLRAALAAPSEAATSAQPAAPAPTCVAELLFTDFAGSERVELNGVTGDALKETQYIHSSLSAVSEVLAALARAHPCCEGHGEADTTARQRGGDRTPLLAAAALVQRWGAMVSRPGVTLSRSPPVFLQPRFAKLGTVRRGEHGDGIGLRRRVLTLMDKCVAEEAAAQWWRRWRAASPYVPFRTCKTTQLLQSALGAPCKLLVLACVRPCSVSEVVLPTSMQDRKGPRTRAAAQSLFAHQAPVMLSEVHATLSFAERISSAPRGCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RM21</accession>
    <name>A0A088RM21_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 1A, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_160150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN96890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697543.1">
        <property type="nucleotide sequence ID" value="XM_010699241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RM21"/>
    <dbReference type="GeneID" id="22573592"/>
    <dbReference type="KEGG" id="lpan:LPMP_160150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160006400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_160150"/>
    <dbReference type="eggNOG" id="KOG3403">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="274995at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05793">
        <property type="entry name" value="S1_IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000370">
        <property type="entry name" value="Eukaryotic translation initiation factor 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00216">
        <property type="entry name" value="aIF_1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21668">
        <property type="entry name" value="EIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1-like" evidence="3">
        <location>
            <begin position="24"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN96890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="168" mass="18709" checksum="397274D37D1E8364" modified="2014-11-26" version="1">MPKNMGKGGKSFKAGNSKGNMQNQKRDLTYANPDEGEEYAQVKKALGNLRLELQLAGGSTVIGSIRGAMVRKVWIGQGDVVLVAKREFNENDVVDIIHRFTPAEVRLLVKENAIPRDFRSAEERDNNGNTDYIFVNDEDDAQDDDDDQNAIDRNEVIMDDPLAALDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMU4</accession>
    <name>A0A088RMU4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_180370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697871.1">
        <property type="nucleotide sequence ID" value="XM_010699569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMU4"/>
    <dbReference type="GeneID" id="22573927"/>
    <dbReference type="KEGG" id="lpan:LPMP_180370"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180008700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_180370"/>
    <dbReference type="eggNOG" id="ENOG502REIY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="278510at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1252" mass="138596" checksum="DAF6B6B1CD5E9E3B" modified="2014-11-26" version="1">MPFSFSSSISNGVGSSGGQDARYPGNTGPSSATASSYGIERPSTTELNDGVIERLSELATAALNSPDKETRDGAAQQLLFLSSYEYWDTLRALLPRAQNNYLRFIVVKGLLFLVSNELGPQERTEMQQYVLEYLQERRRSGEQLPFYLYNALFSVYASALFSNWKISIIRAESAEMVDSSEMAHNILAKLQTYLTTEETLDCVLEILTFFARQNSRLSILSVKSSFAKQVLPFFFSAAASMLSSAPEKAALVCSTALECAPELDAPMVRLHHPSDTTITVLRWPAWAPALSQVMNECGQALLNHPEGPCAALYSRLLRQCSTVTSPQEEYIASRDDVANVLLDVSGRLVLKVQENPGRTELLRLACALLVNTFERNDETTVAYLARDPGAIRVWADATRYVLSRPFDDEEADLRQALLHLFFMIAERMLPPKPRGGRSLEESFTGHYGACTPPRTREGGLAEPGFSAERLGRQPHPLPVGAPRGPLSSERTREVEQQVIDIFSTYVDLVINTAHEREESQELRMSSTFVLQAERMLQPIAEVLFCERIDLLPQLVDRLQQTIRQYELCVRARGEQQAAMHSAAATGGDGGIDCLGLSARSLLQELYMTLAVQNMSVGAALSSPAETTESTPLFFTYVCLSRLSVIVSIFAIALLQGTANQDDSVLGAIAAFACQLLVQEDQVTANLLQCLSLLDDGNDELNDFGGTTALAMPTSSGHAAQVHIGILRSLFFFCSCVYETNLSRREEFYDITVNLLCYVYRYHSDQVALVGDANILLTRIVDFGSSGTFFLGAGKLMGLIEAVKEDELPLLRAPLTPPFAAGALQLPSEVAEARHGFLTAFTFYVETRYYAGFPIADVISALTERCFDDTRMRVSPRLSFQDLKAITKGIHQPDTLQLMLESIIRHKDVCSAVVRYETAVAPDMVAWLSVLCSRSGQYMDEENLSTTQWELTSLVMNVLCFYFSHLSYPSSPMTTNSDGTPAFGAPPNIDGGVALSDNVDSSFMMNGGSGSTFFSFPADAVEAAVVYDVSDILNTFCSAPWCNLGIVLYYERATVEHFFCGAVELLTTTSVQLLMSEEGRARVFNAMSAAVNSSGHTFQQLHLLYMRQGVWNRLVRQLTKCLSYMYAPELIDILYAILRSDHEARQRVPHYKGLEEYTLAATFNEICTLVAVAPHLTYREMAACFGLLQMCYDSAKMLCGEYADRLLDLCSAYHRVRLRLIINSLRRGDGTHLMTEYMTYFGQSSNVGVLTAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMW6</accession>
    <name>A0A088RMW6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_131570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697237.1">
        <property type="nucleotide sequence ID" value="XM_010698935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMW6"/>
    <dbReference type="GeneID" id="22573267"/>
    <dbReference type="KEGG" id="lpan:LPMP_131570"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130020400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_131570"/>
    <dbReference type="eggNOG" id="ENOG502SMG5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="261100at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050836">
        <property type="entry name" value="SDS22/Internalin_LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652:SF7">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="462" mass="49987" checksum="1186AE64EFE532EC" modified="2014-11-26" version="1">MDIWITKLRQAHTCLLTDDAYRNSTMKPQRLLGRLEGDALVEILKFAPDNLRLTLAAVSPKARLFSELLESRLPTNLRLLLDDSTVMHELVCEAADVSCVQPLTTVTWWIEKCGIFVSVRGDKTALALLASSRLRPILRSISLSLLVHVCPIPTDVALHLERIDMCGEAFASLSANFSQMVQLRELHVAHCTSAALLRLSQLPGLLMLSIESRIGVASLDNTIVAENPQQNLDRVDEIDMRRLASAHSLQHLRLSGSGLSVMTGFDCCASLATVTVINCGRLLSLSALAHANNLRTISISWSGVRDLGGLSSCACLERISIDTCREVESLAALAGAPRLQEVDVFCSGVRDVNGLSSCPCLETLRVAACRLVTDLSPLAGAPRLRIIDASFSAVRNLRGLGTCPSLEVLRLDACVAVEDLSPLADAPRLKCVFVKGLDHAALLYPLSLMPKIFPTAAAESLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RN45</accession>
    <name>A0A088RN45_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_180640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697898.1">
        <property type="nucleotide sequence ID" value="XM_010699596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RN45"/>
    <dbReference type="GeneID" id="22573954"/>
    <dbReference type="KEGG" id="lpan:LPMP_180640"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000021700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_180640"/>
    <dbReference type="eggNOG" id="ENOG502RXQ1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272846at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="337"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="421" mass="44407" checksum="92E85D894D1092AD" modified="2014-11-26" version="1">MPPLTLEQVLARSMRLPPQRAQQQVARLYKRHESAELAGSLGEAPSTAVGSSSVGSAVPSSSRIAAMMGGQHVAKRGSALRSSVSTTAANKEKLDFFELMEREDAQRRASHLSIHSSGHLVRNSADLTAYLKAAQRTGDWEGGLQAFAEATALPAVAAILTASEASAAAAAASTTGTSILSTSPPPAPSGSGVNPNMVQISAILEMCASAEKWDLVEKIGAFFAPAYPDAFSRAVELLARRPSSDSSAGERGWRSAFAYLTTRCPLPAAEISVEAFNVCLRACEAELDWRGALEVVRAMGPNPLQGWWAAEEESDKVGTAAVEASVSRLGTTSDLTEADTLSSSLSTASTPSVPPMSTPPSPNVVSYATLISTLEQGGKESLASAVLNRLPAVEKEEITASYAALIMVWSNQILYKRRRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNA8</accession>
    <name>A0A088RNA8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chaperone DNAJ protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_181390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697973.1">
        <property type="nucleotide sequence ID" value="XM_010699671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNA8"/>
    <dbReference type="GeneID" id="22574029"/>
    <dbReference type="KEGG" id="lpan:LPMP_181390"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180017000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_181390"/>
    <dbReference type="eggNOG" id="KOG0713">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052812">
        <property type="entry name" value="Plant_DnaJ_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44272">
        <property type="entry name" value="DNAJ DOMAIN (PROKARYOTIC HEAT SHOCK PROTEIN)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44272:SF3">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="5"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1003"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1003"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1027"/>
            <end position="1036"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1102" mass="120444" checksum="39C53E5D13973954" modified="2014-11-26" version="1">MEVRRHYEVLCIANFSSAEEVRVAYKSLALKYHPDKNLGDPTAADRFRAVCRAYEVLSNEEAKRKYDLQLRVALAQLSHQTCGIAGAYGGANPLWMNNPTTTSDIYRELYQRQAARVSVRSRTSSAPPKYGKKAASQYTKEQHEHFRKRERERQQELCRQREKEKKEQRDRDREALRKEQERQEELLQQRWRQQQLQHQQKVYLTRGSRRTTTAANTASASTTTTSDSAAHAEGCNGALPRTRRRPSRVLTTLARNDASTTPRTCQLDSPFSPPPQLATNLRCAQTGGSGVPSPLSASREVEGGSSTDWHSPLTTSVNNSGLEEGLPRSSTPSSDARSDVEAEVQAMAQQTGVSDAIRTPRAPLSRPASGAGGASGVDSQSGVPAQPSTHTTAATCEDRGDGGAAAGCGDDHHTPSSSRRPATRIATVNVASVRATSSGATTPHQGGKSRGFTSFLAASAAAPSSLRASPRGQASTPRGFSVQATVNRRSHSLSAGVTRSRAKASRTLPRNGNNFNNVPSHSNSAHASLLHRVRPMTSLAEEDKEVLDKKRRGRQVREKERERATQLTEAERHFHRLSPVAKQSCEGTATLSAAAVVGKAKAEESLSFEGQLRYLLQDEANERDQLIEREEQLAWRRLHRQHMAVTQAVVVRRWLAALPREEVLWRNGLLQVYKAERDHYFFYFYERLDRLYVEACEGRDRRQLVGRGAADKYYLHRASQRRTSMAAGEGSQWSWFSVSATQMPLGQGMPVAGAGNRASVPTAEAKDRYHLISRIDEEADHFEDWPEAGLRLAGNHPWDQKPLQSHQRRSAEWLPSASDLLPYEAPAAGSINALGAKRSGTTSAASPAAMTGVSASGYPASFLSATSTPERAPTTAGILPGGSASVRASAQANYYEFSKQRSSFASVINPDLTVLSAVTSANGEPNILLTEARRRLLTLLSDESLQRALLVKQQQEEEMALRRRRAIALHNVFAKDREKAVKHAQRCAFVEVAVLKSQLRTLQQQTGRSSSSHRFEGGSPTAASRADSGSPTNSVSFPLESSKASRHRSPLPLLPRSTLEAATAARASLSGRARAFSAASAFTSATVLSGWTTLPDSDVEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNK6</accession>
    <name>A0A088RNK6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 5, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_200360</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698235.1">
        <property type="nucleotide sequence ID" value="XM_010699933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNK6"/>
    <dbReference type="GeneID" id="22574243"/>
    <dbReference type="KEGG" id="lpan:LPMP_200360"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200007400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_200360"/>
    <dbReference type="eggNOG" id="KOG2767">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250831at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071074">
        <property type="term" value="F:eukaryotic initiation factor eIF2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.170:FF:000002">
        <property type="entry name" value="Eukaryotic translation initiation factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF7">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="7">
        <location>
            <begin position="198"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="161"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN97528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="378" mass="43228" checksum="E528F526DFCE1470" modified="2014-11-26" version="1">MATQMVPIDPDKKDDVYYRYKMPAVQTKVEGSGNGIKTVLPNIHDICLVINRPEEVLMKYFQFELGAQRTVSTKDDKFLLMGAHPTERMQDKLYDFIRKFVLCKYCRNPETAIHLDAGKKGSASISMVCGACGKRSNFDEHRTKTFMTQYYEKHPVEAKAAKGAAEARKKEDAPAAEEAAAPAKQEKESGKLVGKSDLTDDREDPKVVFARVLKESWGKNDELVGRTVRLLSQYNLPEHYGPPMALSAMKLEHRDDLLSTMKTHARLLKRLCTVPELFSRSEGYDEKELTEFYKREKKIQKTFLRECAKEFAINYTPDKFAVLIFMLFVEGVLRDRSIVDWSKDTKPFSDVDLKVQEEMRQKVAPIVSWLGMDAKEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNR2</accession>
    <name>A0A088RNR2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_202080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698409.1">
        <property type="nucleotide sequence ID" value="XM_010700107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNR2"/>
    <dbReference type="GeneID" id="22574417"/>
    <dbReference type="KEGG" id="lpan:LPMP_202080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200026200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_202080"/>
    <dbReference type="eggNOG" id="ENOG502QVGQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275869at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="334" mass="38291" checksum="38A851BD6C1ED657" modified="2014-11-26" version="1">MLRQGGRRLAMEGERQFFFPGSSPMQSTGGLPFYGNLYAGRVDSQNYVPPRQGGSGLLEVDKSLWDNPATRQKLQSCPYFALSDQVMFHNMDPVYLDPGLLSPEEHQLLLLFSRAYYEKWSVIHRRPPNALPRLRITYGSSKLLDEILFLLDVHPDVCKVLKKEYAVDDSSLIGMNPDLWSSAYLDPANMDHLSGRVLEFAGVPEPQRKKFFLLLNQMRRIKVHRRDLSHGEERVDVVPFSHGVTLYDFCTFLSIAPYSGQLKVYDYVDLQGTARAETLKDEDSYFDYLVALFYRADVRSATLTDMADASDHTCRYTVTVEPFTADDRRVGRWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPN5</accession>
    <name>A0A088RPN5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_204340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698635.1">
        <property type="nucleotide sequence ID" value="XM_010700333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPN5"/>
    <dbReference type="GeneID" id="22574645"/>
    <dbReference type="KEGG" id="lpan:LPMP_204340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200049600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_204340"/>
    <dbReference type="eggNOG" id="ENOG502QVDU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="437960at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23084">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23084:SF227">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="412"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="444" mass="49130" checksum="D56D7F0581923EE1" modified="2014-11-26" version="1">MLRRLGSTLLCSVTLDNGAVLKGVLNPKNPTLLLKGITILPDGRVYSGTYDPVSGFPLPGSQLEEDGDLYRGEFNIQWQREGRGEAWLADGTHYAGVFKSDEITEGVVRIPNGTTEVVFEGTLSDEAFVRGRLTQSDFVYEGEFSDNQPHGRGKLVFATGALQEGTFFHGKLHGSDCKMKLEGGFVYVGEFLDGKIRRGTLYTPTYTYEGEFNEHGRAHGEGAQTYLINEPRLTFTGIWNNGALVRGVCMDEYGSTVDWQNNNELQAKVLGGSTGKGDESVGLNSYCGARMKEAAQMHSDMQRSYAEDADAVAHLTGRFPTKMDLGYEGSIAHENEAVLQAQQRQMHDIERSRDVLSERAKEYDTVASGARNNIIGEINENMAKIQFRRQVGAEEVSATRINEQFERFMKDFKRPSPLSSAPTNRAPKLNIDGNAPWKAFTPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPR8</accession>
    <name>A0A088RPR8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_180330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM221 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697867.1">
        <property type="nucleotide sequence ID" value="XM_010699565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPR8"/>
    <dbReference type="GeneID" id="22573923"/>
    <dbReference type="KEGG" id="lpan:LPMP_180330"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180008300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_180330"/>
    <dbReference type="eggNOG" id="ENOG502R7X0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="196393at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026755">
        <property type="entry name" value="Fam221a/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31214">
        <property type="entry name" value="PROTEIN FAM221A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31214:SF3">
        <property type="entry name" value="PROTEIN FAM221B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14753">
        <property type="entry name" value="FAM221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="400" mass="43779" checksum="8443E8383418D546" modified="2014-11-26" version="1">MSARDHGTVAPAYGEIVESDKVHGEIRELGTQVKSMIAQHLPRHGTSKEQVMWGVRQFGPSKESRRVLNKENDAARLAWETGVYCVWRCCEKPRLSGANQDFCCRIGYQHVCFCSHPLAAHTTPGRAANSSAAAQANCSSDKERVGQDSVSGNALVCASSTALVTDVQLTRWKGPCEVAGCPCAWYRYVPNTPLEIGEEWLTRRANWKASEWSAKCRCGHGHKAHDPKTMRCRSCGGCSGFTSAFLCVVCDLPWEAHETVWESEGVRLGDGHPVCEGYAPLADIDWDIRALALTDVSMGGRIEPPATHLALQQRFNNTRDVTTTIARRSIASARPSSTTAMKDREGGPSAGVLPAITASVADPILDVEYCRLCATVYKRPESKFCAQCGQPRPQRLTTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQ02</accession>
    <name>A0A088RQ02_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF1736 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_204360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698637.1">
        <property type="nucleotide sequence ID" value="XM_010700335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQ02"/>
    <dbReference type="GeneID" id="22574647"/>
    <dbReference type="KEGG" id="lpan:LPMP_204360"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200049800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_204360"/>
    <dbReference type="eggNOG" id="KOG1124">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19588at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052346">
        <property type="entry name" value="O-mannosyl-transferase_TMTC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013618">
        <property type="entry name" value="TMTC_DUF1736"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44227">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44227:SF3">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE TMTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08409">
        <property type="entry name" value="TMTC_DUF1736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="473"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="498"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1736" evidence="6">
        <location>
            <begin position="349"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="722"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="731"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN97930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="919" mass="104340" checksum="700E97FBCCABA1BB" modified="2014-11-26" version="1">MTCSRVRLLTAMSDKVRKGVPAAENIPWQLVYPVDVQIHSFMLLMAAIIFSNGILGDMTFDDHLAIDKNVDAWANKTSLGSIFYNDFWGKPLDRFESNGSYRPITVLTFRIQHWLMGYRHSPAFLHGLNYTVAYLNVCLVFYLARLYVYVVVPRAVLSVENAKAQSCMAVLTTPVHAVPLIAALLYLVHPVHVDAVTSIVGRCELLYCFFGLIGFFGIHRYLNQVDELIDAASVTAAVSSASPKVKALSATATAAKQVYRELKQQGHSRQRIFTARYVVFAAYALIISILCKDSAITFTAIYGVHACVMYACGRCKGFRSLLVIGVAVLELASYIVFRRRFIGNIDMHKNPLLRQTENPQYFVPKGLFHWLSIRWLIQVKNLELLFFPTSLCCEYSFNCIPHMHDLKDPRVPYSLKVTGAAVVTLLGLLYGTFASRSRVALVGLVGFLWIAIPYAPVSHLFIAVGTFIAERCLYVPSIGAVLLITFIVAAPGLREGVVPRYFYTLLLLCVGWGIFSRRRNEDWWTDERLFRSAMRTCPNSGKVYSQLAALVSSREQRITPEVVELAERSVELDSKLRDGYYYLAVHEVNDNHNMEKAYRYLRLCMEDPFALHLCRDSYEKVRGILFPKMTEMEQLIDYASLMVLESQKAAYLRQAGVIALQKYRKPCVAQQLFGEAMDRWNNSKLYWVSDEVKRRSGDATYCNALYWYVQSSLECEAQDMAGTVESPNAEDKEDSGGDDVDSSSSKVSRRDIPLTPQEAAQRAVTAGERLRSCDTDWHQVLSELQYNLPTIPYRMTQYLTVGDSTGNMLSHYANYTQRNTPERNEVLLIFLDITVRQYCHIHTLLNDAHVRKEVNSRFRFHLQSIERGFPIFRQHRLADMRTSQRELKMTTTLNATQQHALKLILAMASCSSDLSFLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQ17</accession>
    <name>A0A088RQ17_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_204570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698657.1">
        <property type="nucleotide sequence ID" value="XM_010700355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQ17"/>
    <dbReference type="GeneID" id="22574668"/>
    <dbReference type="KEGG" id="lpan:LPMP_204570"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200052400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_204570"/>
    <dbReference type="eggNOG" id="ENOG502S6ZY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272674at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="390" mass="42214" checksum="ABB3B7B3A721B6BA" modified="2014-11-26" version="1">MQFVFAVKGRSSRAPQLLAADRLFVVAARETTHRARHARGWGKRRYSAVAPAPGAPLQISGSRLRDLCWGESPLSSILSLEKDDLKFNCVIVQTPYAVRAANMDVEPVSLRVIAADALEHVFFNVNEDLLQDGRLVVFTYADNLLHVGIDANAWAEARVAATAASTGVAVGDGDGSTGPYGHASGPVSEGATNKDPSLSADSGTDAELAKRPRRVDVVWGKEEPSRSSRRLDSPRSVLKKEQVLAVVPCTVNGDDIKELNELIDEGKLASFDVSLTDFFCSQCYHLPLLTLTMSCCGAVLCQCCAPTPPTVEGVSATDRACPVCGEEPLDPPLSHPERDVKVAKLVKELKVLYFPQLRALRESRRVSVEPPKPSMPPFLLLNTPVLEPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQ37</accession>
    <name>A0A088RQ37_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_204820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698682.1">
        <property type="nucleotide sequence ID" value="XM_010700380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQ37"/>
    <dbReference type="GeneID" id="22574694"/>
    <dbReference type="KEGG" id="lpan:LPMP_204820"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200055000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_204820"/>
    <dbReference type="eggNOG" id="KOG0229">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264642at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215:SF14">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="384"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="129"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="435" mass="46680" checksum="D18667E38F892571" modified="2014-11-26" version="1">MDMHEVHVAATAADTTATAQQPSAELTATAPFAEDPTVHPNPQSPPSSTVSGTFSATTGVAEAKRVTATLSTAADSLEPVLVGKVVSAEFSEARSTRQASDLNAVQNDTGPPRRVHSGEQKECFPPATSASFSSSSNSNNDSSNGDASFDHIELIFDFGRYVGQVDPLTGLRDGHGCQHYNSGNVYTGEWRNGAADGFGEKCYKNGDVYRGNWRQGKRSGRGAYLFAQGDFYDGMYLEDDPEGYGIYTTLKGDRYAGRWKAGHKHGKGRETLVNGQVFVGNWRNGKKQGRGKLYLPGTERYIYGIWNNDKFFRELTATEMGVEGEEDIVDEFGVPRDPFAPPVAPPWKKPPPSGGGITDHVLMGVTALEDRMESLGRALERVISGDDGDKNMQVPPTVAAGTADSTAGSVASSEECTGLPLHGFIVNNSHKGDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQA8</accession>
    <name>A0A088RQA8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RPS6</name>
        <name evidence="7" type="ORF">LPMP_212100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698994.1">
        <property type="nucleotide sequence ID" value="XM_010700692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQA8"/>
    <dbReference type="GeneID" id="22575032"/>
    <dbReference type="KEGG" id="lpan:LPMP_212100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210024800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_212100"/>
    <dbReference type="eggNOG" id="KOG1646">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10260596at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2650:FF:000004">
        <property type="entry name" value="40S ribosomal protein S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_eS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014401">
        <property type="entry name" value="Ribosomal_eS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018282">
        <property type="entry name" value="Ribosomal_eS6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11502">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002129">
        <property type="entry name" value="Ribosom_S6_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00578">
        <property type="entry name" value="RIBOSOMAL_S6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="222"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR002129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN98287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="249" mass="28340" checksum="CB5CC5EC5F2FA43B" modified="2014-11-26" version="1">MKLNIAYPRNGTVKQFEISDEVLRRVQLQDYRLGNEVDGAIFGGEFKGYIFRLRGGSDKDGFPMVPGVLASSRVSLLVKRGAIGFNTFRGYQGERRRKNVRGCVLASDIALVNVTISKVGDQPIEGVTDTTAPRRLGPKRASKIRKLFNLSRTEDVRRYVVRRRVLKSGKKDRLKAPKVQRLMTPKIKARRAKKAKDAIAKVRASAAERREYLRLIASHRRALRQRDHSKKHTHKVHTQRAEVAAFQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQX2</accession>
    <name>A0A088RQX2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_230610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699219.1">
        <property type="nucleotide sequence ID" value="XM_010700917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQX2"/>
    <dbReference type="GeneID" id="22575265"/>
    <dbReference type="KEGG" id="lpan:LPMP_230610"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230011900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_230610"/>
    <dbReference type="eggNOG" id="ENOG502QTK8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264829at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="452"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="488"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="551"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="613"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="898" mass="96915" checksum="4D0D070970E5241F" modified="2014-11-26" version="1">MPLYSIKVCPLKLNAYFCRQGSTYVVVMSRKGLEIATNPSVCNNSTEVIFSDVDGLNDTKAFELSFNSPKDHRALNFSIYDFTNRKNTAKLTGFEIPLAGICSVLAGESMCEKKGISFRVSGHPGRLDVLFCMHPVGTPVPQLRVVQTTESISGAATGAQGANSQRNAAVPPADTGGGDAGAISTGPTRLPDHTLRVLLREGIISGNFDGIEMDSDLANEIAVRTSVLFPSSADLEDQIRTVTREIKKLEYDAQYAAKDKVTTGSAASAALRNEIDYWKKKVKNIDDNSAHEAGIAPNLEESEPRQDVTQSRIADIEAQLIAKHLDMGSLEALQSQRDVTQDVVKLLDQIDYLQTLLTELKSQETVRETPKAKYYDISENGDCWDKLAAKLYDAESMTEQLKQTIIALNRMQYEPYPAGIEAGLMHTVPQELEFVKHNKHTSRNAPPQVGNASSSAAALPAGQPAGGVATGNLLDDLFGAPPPPPAPQAQSSSAAENPAALPLEPFLGTTYEPPKAAQVTPIWAQPAGGAASNMPPVQQSPQPIPAATGTPGSPQSQPEPAAPAGDQPPSQPLAAPIGSALLTSSAPIPNTPPPDAKEALPETSVNQQNPDIASAAVSPVAPSPTSVTPPSLAAPGQTPQLNSLNVSQSSLTTLPAQAQQQQPQPQQAPYGQQYGQQQQQQPQPQQAPYGQQYGQQQQQQPQPQQAPYGQQYGQQQQQQPQPQQAPYGQQYGQQQQQQPQPQQAPYGQQYGQQQQQALQESSVPYFERRPPSLEEIPYTEFYGIPLMARGCPIDIFLDGKTPTRGTELTFINNTDQQIVIGGVELKQEDMFSTDPNSVKTIPTQRWPQYLLVPGGGSRQSCTIALHPSFPRGSFIMALVVAYVFSEGRYTPFMARFTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RR46</accession>
    <name>A0A088RR46_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Multiheme cytochrome-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_220710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699072.1">
        <property type="nucleotide sequence ID" value="XM_010700770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RR46"/>
    <dbReference type="GeneID" id="22575117"/>
    <dbReference type="KEGG" id="lpan:LPMP_220710"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000053600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_220710"/>
    <dbReference type="eggNOG" id="ENOG502S9Y0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276203at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="Multiheme cytochromes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="215" mass="22942" checksum="B3B0536B943C08AC" modified="2014-11-26" version="1">MEHSKTASELQQEHSDELFARQLQAQLNNPGDGADCAPTGSGPLVSVQEAADAALARQLQEEINRQEAAAGAGTPTAGAADMVPVECPACTFVNYIKPSSPLKHWKCVQCREPLKEKVPHSNHSTHKDLVECKVCHSFNKLPSKKSDAVLCGGCYQELGSTLNTAPLVDSTANQRTVQLRCGQCNVINAVTIGVDVKKLEFICGGCGVLNTMVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RR57</accession>
    <name>A0A088RR57_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_220820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699082.1">
        <property type="nucleotide sequence ID" value="XM_010700780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RR57"/>
    <dbReference type="GeneID" id="22575128"/>
    <dbReference type="KEGG" id="lpan:LPMP_220820"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000029800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_220820"/>
    <dbReference type="eggNOG" id="ENOG502SWQW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="260919at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="1">
        <location>
            <begin position="20"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="373" mass="40770" checksum="CB0E92EBB937F087" modified="2014-11-26" version="1">MLLDKDKIRLLIITEATTCLPGQHVTGVLRVEVLKEVSVTAIRLVARGQEAVFFKAKKDRFTITRQQSFVHFEHLITFFGFSKECGRRGGASLAPGIYEYPFDFEIPASAPPTYNCHTSAGDAEIAYVLRAIADIPRGFDKRTEIPLYVLPTIASQQYEQLCRTDKTMVTRDIPLAVEPGCFGRSRDPKASVTLSVSVPAVALLPWRSCGNTSPASSPTATNYLNVHLSLMNTSLKTPIRTVRVTLSQQQHLIAQGDSYNTIQPIVSVVVSPPGGELIPRASAALDVKLRLPRSLRHLSKMPQRVPLPTLATPCIQTRNLLTISFPGLGADALVNMSDATVIGAAVDYNSRVPIVPCFYTMATIRPEDKLGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RR74</accession>
    <name>A0A088RR74_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_231580</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699314.1">
        <property type="nucleotide sequence ID" value="XM_010701012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RR74"/>
    <dbReference type="GeneID" id="22575363"/>
    <dbReference type="KEGG" id="lpan:LPMP_231580"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230023800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_231580"/>
    <dbReference type="eggNOG" id="KOG1315">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="123"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN98607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="320" mass="37369" checksum="02227C218F896304" modified="2014-11-26" version="1">MCRGNIHTVRPRTCCEWWLLSCSYIPCVIAMALIMANTFPYHLVFLPVLRTACEIGNAHIVYYYYCLVVMMLAEALVYSNLFLVIFTCPGFVPHEPWVEAPVYQGRSVSDNPYEVFELDRLGRLRYCSFCKQFKPDQAHHCHTCRCCVYRMDHHCPWINNCVGRGNGKFFLLFLSYIPLGAFHIVATTLFSCVFHFPNFFSREMPDNSLTSIVLLFSMLFSSIMGFCFLVFAAHFLFMAYRGQTSVSRMIASKKHPDTLEEVRKRQAEDRTFYMFDLFGSDQRWYRMMLPFKPDHDLRRAPHGYLRRFGGATEVAYMSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRR9</accession>
    <name>A0A088RRR9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclin 11, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CYC11</name>
        <name evidence="2" type="ORF">LPMP_241850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699524.1">
        <property type="nucleotide sequence ID" value="XM_010701222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRR9"/>
    <dbReference type="GeneID" id="22575594"/>
    <dbReference type="KEGG" id="lpan:LPMP_241850"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240025900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_241850"/>
    <dbReference type="eggNOG" id="KOG1674">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="337735at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20558">
        <property type="entry name" value="CYCLIN_ScPCL7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF126">
        <property type="entry name" value="CYC2-LIKE CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="749"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="775"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="812"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="882"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="903"/>
            <end position="917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="936" mass="102702" checksum="9FABB4CBC807E413" modified="2014-11-26" version="1">MASLGAEHKLECKSMVLTLHTLFDIPRDLVSLDPRRESVELVLKPTAKYYLDNKRFCKLDLPEQHVAFSPSSIIFKRDRFVLDFESVPPQCGLSFTRSASPHRATSFANSMPSNFVDSLTAHGTLTAPGVASSTGKMPLHFESDARAGGAVPSNPRFAFGENVDEDHDVNLKSPSSLKLKTSTTFSSATPPNQIVFRYPTRSDLKVIIEVMVGARQRRHDSAAVRWITPSWADRSISGTVSTFAAADGEVMRHKLVNRFVGLTVGNLSCTMELPHAADDLREVLEFSPTAIADAAERLCNDYERLRRFHTADAAEQLNALQNERSMRLRDFVEQLSTGASESSVYRSLLLEVCPSFFVRRIRRICAMYPPIPQSSSWVRTDPETLAAEYCGREMSLIRSLCAELGPDLSAISPRNRFLSYTNIQPLGDELWKWIKDNYANQENDILDYEPDVFMESLALHYGTSEPAPIQYGFSPISYELDRRAYFCDSLRFPVNREHHRYRDEAMAARQNRVPLQLTPCERPLHPIRPTSRNIGEIDILLEKYKPEFVQLVPSIADAMECVTQQNERLLRELLRESQPTGGSAARNVCTRERMRSLPYEVCPHGFHLFQSERPSGSYVALLTRFAEYTYISVSTLLSAVIYLDRLCLRHPRLLLTTRNIEKLLVAAVRIASKVVDLRSVNNKNFASVFSVPVQDMNELESEFLKLMSFDVFLSPKEFNNYAHLVQLPAAYMQMPPSVRLSNTANANGIGGSIAPPSSAVHEQADPVADVGHSGNGTASRVGSKTTNTSNRVSLNTPAVTTPALPRAPSPQPQHQRYATRGSSSAMAPDSAYGNDAYAAAQRALPPDKPSSKADDSAVTGVEAGGNYTNGSGGAAGHRYGRSGLGGGSGGRGTMSANRYGSGSSAGGASGGGSGGTNGNKAPSPEFESGMRVLSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRW5</accession>
    <name>A0A088RRW5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_250120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699584.1">
        <property type="nucleotide sequence ID" value="XM_010701282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRW5"/>
    <dbReference type="GeneID" id="22575660"/>
    <dbReference type="KEGG" id="lpan:LPMP_250120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250006200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_250120"/>
    <dbReference type="eggNOG" id="ENOG502QVEE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269770at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="457" mass="51816" checksum="650F7A3C815E2913" modified="2014-11-26" version="1">MTLSSSFNTVTDKNRFTSLELLLQKLSHYVGRRQYRMASDLTQHLEQFKALGIDWHELKFLQRGELVELFSGPLKLNHAERAVLLTALEAKVCGVLCRDTTRHSTKLCLNPGVVEHGWRCGEDGHTNDVYFEGKEQANPAVLQLAHRSVSRVARRDGIDVEVRHEPDFAIVGRNSTELNPRIWNAPKHSTFVVTPIGYEFRVHPDDPRAVHQIEQAAAEWELHLEVVQQVISEVLELYAVERGEQALHLMPGEIGEPDVPEVYSSAFHTRRSSSLQPKEDGAVTEHRMMSASGAERPWFQTPLPQRFTRGVPKLLPFAPTIILHSTFRSIERDISSADVNRRLMQPVMDISCLVHPNACFGWNAEEEERSTRLILDYAKRMPFALPFNLYFRVDPAKVLRAKPALVVEKDTLLRAKFSLFDLRHFRSAARTTAAESDDALHPTEQESTHGCASVTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RS71</accession>
    <name>A0A088RS71_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_205880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN98079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698786.1">
        <property type="nucleotide sequence ID" value="XM_010700484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RS71"/>
    <dbReference type="GeneID" id="22574800"/>
    <dbReference type="KEGG" id="lpan:LPMP_205880"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200066100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_205880"/>
    <dbReference type="eggNOG" id="ENOG502SB2V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="242330at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="121" mass="13268" checksum="F1097551A7A5F1B9" modified="2014-11-26" version="1">MSRVADNINVVTEGGAPVSNGEENLPFLARVINHVLTPGSSLSPIVWISFNMVMLGLFGVWLMFVVAMPTNIHVWAFGFLGVGLTASTNWLMKIIFSSGLDFASQQQREAVVKESKDRKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RS85</accession>
    <name>A0A088RS85_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_251340</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699704.1">
        <property type="nucleotide sequence ID" value="XM_010701402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RS85"/>
    <dbReference type="GeneID" id="22575782"/>
    <dbReference type="KEGG" id="lpan:LPMP_251340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250019100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_251340"/>
    <dbReference type="eggNOG" id="KOG0371">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000003">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="7">
        <location>
            <begin position="122"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN98997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="317" mass="35957" checksum="567E7681D606973E" modified="2014-11-26" version="1">MTTAGSGPPVGSSSTLDLDEMINYVIQCKPLSEQQVARLCEKVKEVLEKENNVHAVRAPVTVCGDVHGQFHDLLELFKIGGLPPDTNYLFMGDYVDRGYYSVETVTLLLLYKLRYPQRLHLLRGNHESRQITQVYGFYDECIRKYGSANVWTIFTDLFDYLPLTALVENDIFCLHGGLSPTVDTFSHIRNLDRVQEVPHEGPMCDLLWSDPDDRDGWGISPRGAGFTFGQGVTEGFCHNNKIKTIARAHQLVMDGYSWTHQDQLVTIFSAPNYCYRCGNLAGLLELDEHMNKCFFQFDPAPRRGEAQVSKKTPDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSE6</accession>
    <name>A0A088RSE6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_241880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699527.1">
        <property type="nucleotide sequence ID" value="XM_010701225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSE6"/>
    <dbReference type="GeneID" id="22575597"/>
    <dbReference type="KEGG" id="lpan:LPMP_241880"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_241880"/>
    <dbReference type="eggNOG" id="ENOG502S4M1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5358702at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF3">
        <property type="entry name" value="PROTEIN PRENYLTRANSFERASE ALPHA SUBUNIT REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="485" mass="54933" checksum="B8B0ACFFABCB790C" modified="2014-11-26" version="1">MESDYTIIADAAKELDQILDSGAVLYLQSIRTPGAQPVKAALGFSLQPLEENRVACLVETSCVAASTTMCIDFPVLVDRCVVTAMRSFFVDSFQRAKSALPQVTKAANQAPDSLDDTPHVTRAMLSNLHPSVVALAWACIPQHDIFVSFRRRWLREKCFATEDTVSNSQKLYCVMKEFVLLDLFLSLFPKLKSLWEHRQWLCYNMCSCGLLIDNLKYVDETTLPILQFEAQDDQSFFMAAHNHPMNYNAWQYRRLRFRTLHVNMSKAGARWDCASVAIQMDCEQVIRFIREHNGDSSAASYLLFLLYEQDALDTKGDACLCGTETLMKSPHQVGGEPHRRYSEEQLNTDKKDESRKCASECSPIAALAPAMWKSLMAITQTEIRRHSEKGHECIWHLRLGLIQWACMRSPQSRVLSLWSAEDELRWTSTYARLHLTEGEDALLSPVSALPYAWSESSGSSAWTSFSASRYGYQLASILRNTLPCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSU9</accession>
    <name>A0A088RSU9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA (cytosine-5-)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_251220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="1"/>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699692.1">
        <property type="nucleotide sequence ID" value="XM_010701390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSU9"/>
    <dbReference type="GeneID" id="22575770"/>
    <dbReference type="KEGG" id="lpan:LPMP_251220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250017900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_251220"/>
    <dbReference type="eggNOG" id="KOG0919">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="414133at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.120.10">
        <property type="entry name" value="DNA Methylase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050390">
        <property type="entry name" value="C5-Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031303">
        <property type="entry name" value="C5_meth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629">
        <property type="entry name" value="CYTOSINE-SPECIFIC METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629:SF52">
        <property type="entry name" value="DNA (CYTOSINE-5)-METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00095">
        <property type="entry name" value="C5_MTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="637"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="394"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="655"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN98985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="843" mass="89104" checksum="EBD9DFB17853486B" modified="2014-11-26" version="1">MASPTSYPSSYPAGIFVVRSKQQLAPLVARLRATRRLKPGRNVTEFDGEHFAELAEAPGSRLPVSAPAMHGGGTVNREEAQAGSANAEAACSLRGTVMYLRETTEAEAAELEMSTQAGKRRGLSGSDGITIPLPTSFSTSKLHSTSMRAAGSGATSERCVIITACDSVQGEEFLSLLRVPYGERAGARWPPYMAAHVVGTFAEAELRELLSPGESNGGSSTGTDGCGGNEWMESSVPVAYIRGIRRFHRVCCPVLAEMPSALAAMRRTALLQRHHRLVQCDEAAGDNTCPPPSLQGATPLLAAAHLQPSSSPPVGLSRDPDAACAPLFTFSELFCGIGMFRSGLERVGGRAAFAVDFAPPAQIVYALNHRCLHDCPAALQLPNATLNGPREDTGGSLTPSSSSSSGTRLTAAASAVACQHAETEGSSLDATACSVPPLVGNITEIPNAFFPTHDVLTGGFPCQSFAKAGDAAGLHAEKGWLFYEVVRVVAATQPTAFLLENVDHLIEVEAGAQLAEILARLRHPTSSLAAPTVEDVAVEYEVQYVVVDGGALTPQTRKRVYFFGFKVASALVPVREASLGYSLSPFTLPRADDGEARATAARVITDALQRIKVTSLDSPYRSVQELLVHPSTVNASRLAPQSRSMRDEPTGTSGGAKSPASSSAHSDLQLTHAQWEAVRRSRTYRQNPLWRLCDLQGRARTLLGSYRTSYQLYSEFVPSSPELTQDEVAAMLLEGMSLRPGGDAADARAGGPEGSAIPAPAPPPLRFFALRECARLQGIEDGFLLPHDTTQIPSSADAGAIPAAVLRQVPSGAVYKLIGNAVNPRVVACLGGAIASYLQERRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RT28</accession>
    <name>A0A088RT28_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_261700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699989.1">
        <property type="nucleotide sequence ID" value="XM_010701687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RT28"/>
    <dbReference type="GeneID" id="22576073"/>
    <dbReference type="KEGG" id="lpan:LPMP_261700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230028500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_261700"/>
    <dbReference type="eggNOG" id="KOG2796">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="428342at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21581">
        <property type="entry name" value="D-ALANYL-D-ALANINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21581:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="516" mass="56312" checksum="5A137412C01EFAC8" modified="2014-11-26" version="1">MASEKAVESAKMFCGPALYAASATHARVTLANVSPNADGLRLLASNGNWSEVLALAERLETEVAAKARRHPLKYATVPRSTSPPESMFLMSSKHSEEELSTTQLPPVTDVTAAAISSLGLSTDAAARSARLPYVLVQVTANLKMRRIAAAKKVIDALGDIEGEGFRHPVTRESFAPFSLRLVAAFLPLYVGAPMEAQKKLYALLEECLRHERQCSANSTVTRIPAVLGDDVANQSAASVALQRTWTQRVLRVQRVLLHVHIHLNQQSLAHRLVEQVLCSEEIWHHKFHDLSDELYQLRHTLQLQQVFCLALHVGDASHAQVTHVAMQRIAAVNGSGTSTGTSPSDAVSNTNLCKLVLLSCDAFSAVFKGEYKKAVILFHDVIDAASHMKQALSTAADGSGRDGRSSPNSDGYISENELRCWVLQDICANAQVSYTTCQAYCSDTDPATLMSTLCTTLEGYAKAEPHVLCNSDAFVESLVRFYTLSGDRKANLNRLEDLLEVFRCDRRSLPSLEALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTK0</accession>
    <name>A0A088RTK0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_261070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699927.1">
        <property type="nucleotide sequence ID" value="XM_010701625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTK0"/>
    <dbReference type="GeneID" id="22576010"/>
    <dbReference type="KEGG" id="lpan:LPMP_261070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260015600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_261070"/>
    <dbReference type="eggNOG" id="ENOG502S62F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264964at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="500" mass="54627" checksum="37508396AAC5FDD1" modified="2014-11-26" version="1">MRHVRGSCGSSRRVFAPWISTWPSATEASIPPRLNSGELLLCSTVEARRSTSTTSSSPPLESSADSFVAKRTRLMAERASASADNVSRLRELLQTCSAHERRGLFSNDQPHRRRDVWPLTTPVEPPTPSPGVTARMKKSVASDTPRFLSTAVIQSFQEGASHNAAAAAQHGTAQCSQKEQQEKGYYHSPSWYGASPGTRMDITYFTAHQSSRWNALFHDLYYTRNEPTAPLLRCPACVTQRLRGDVAMLPRTGFADLSASRAATETPSASSPLWMDPMELQRHLSYIHADELFTPQELKLYNAQVLRELRYSCGLAPALTPVEGELSTGVTSGARKMQPARVILVVDVANVELGSPGELLEMLLSSKLLRAVTDFPVALCATHELFVPAISKALHTLYQLSRRHPASTLHVFFANTSLESGDLLTSSYLNDLFLASPHCAVPPVVMLTSDVQQQRALTELHGAPAYGMGNGGHVHWVKPLTAAQLVVDLYAALESSQSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUJ8</accession>
    <name>A0A088RUJ8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_250860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699656.1">
        <property type="nucleotide sequence ID" value="XM_010701354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUJ8"/>
    <dbReference type="GeneID" id="22575734"/>
    <dbReference type="KEGG" id="lpan:LPMP_250860"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250014600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_250860"/>
    <dbReference type="eggNOG" id="ENOG502S64W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="260220at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="22"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="420" mass="46987" checksum="35204378D546579C" modified="2014-11-26" version="1">MILPPHDAEPLAAKQTLSQPAPPLCEGWLEKLALCRGLFAKKGWHRRYVFATHEGLGLCHTNPRDKGNCARGRPLRIRHAKSFISFVKRRNGEMELQPVYIVDDVSAARHPEAPKKSYNGICSETMSLIEGTSNSTSTRDLSRFTSATNGNSCTYYYFGLTFEEYSRRYLLLFRTTSPQEYIKWTTCLPLYVHEGSASRIVPLGHPLEAGRQQPIDVNHRRLTERREWRLPNATFYLDPDPCTLAEHLKVRRLCLSWDEGERRRLFTTATERVCSLCGKSESAASAFITELQEQSEEKHRNAMFSLFEELSPTMFEYEEQHSARYRDSSEPKRVAAAISSVGMAANSSGAAHPPATQVDSAEDAAEYLSMGESTNQSASRRPLSRIPDSGGGAGSGSKEAHKHPRLEKAGATPYSDSPNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RV37</accession>
    <name>A0A088RV37_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Methylmalonyl-CoA epimerase, mitochondrial</fullName>
            <ecNumber evidence="7">5.1.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">DL-methylmalonyl-CoA racemase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_260040</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Methylmalonyl-CoA epimerase involved in propionyl-CoA metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:20553"/>
            <dbReference type="ChEBI" id="CHEBI:57326"/>
            <dbReference type="ChEBI" id="CHEBI:57327"/>
            <dbReference type="EC" id="5.1.99.1"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="5">
            <dbReference type="Rhea" id="RHEA:20555"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylmalonyl-CoA epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.99.1" evidence="7"/>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699826.1">
        <property type="nucleotide sequence ID" value="XM_010701524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RV37"/>
    <dbReference type="GeneID" id="22575907"/>
    <dbReference type="KEGG" id="lpan:LPMP_260040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260005300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_260040"/>
    <dbReference type="eggNOG" id="KOG2944">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004493">
        <property type="term" value="F:methylmalonyl-CoA epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046491">
        <property type="term" value="P:L-methylmalonyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07249">
        <property type="entry name" value="MMCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000003">
        <property type="entry name" value="Methylmalonyl-CoA epimerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017515">
        <property type="entry name" value="MeMalonyl-CoA_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051785">
        <property type="entry name" value="MMCE/EMCE_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03081">
        <property type="entry name" value="metmalonyl_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43048">
        <property type="entry name" value="METHYLMALONYL-COA EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43048:SF3">
        <property type="entry name" value="METHYLMALONYL-COA EPIMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13669">
        <property type="entry name" value="Glyoxalase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0170">Cobalt</keyword>
    <keyword evidence="3 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="10">
        <location>
            <begin position="17"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00050406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00053742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00066411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN99119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="151" mass="16431" checksum="C1B9015CB1506CC5" modified="2014-11-26" version="1">MFRRSIASLAMPANLGRLNHVAIAVPLSRSIVEAGEVYKRLFNVKVSDPVRQEEHGVITVFVEMPNSKIELLHPLGNNSPIAAFLERNKDGGLHHICLEVADISAAMLTCKEANIRCLGAKPKIGAHGNPVIFLHPKDCGGVLIELEEVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVV2</accession>
    <name>A0A088RVV2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_290900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700698.1">
        <property type="nucleotide sequence ID" value="XM_010702396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVV2"/>
    <dbReference type="GeneID" id="22576854"/>
    <dbReference type="KEGG" id="lpan:LPMP_290900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000044600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_290900"/>
    <dbReference type="eggNOG" id="ENOG502RXC8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276985at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO00041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="491" mass="54003" checksum="A7545F6F427ABEE5" modified="2014-11-26" version="1">MFYAVNHLRAPLATLKPVLADSIATQNVIRRMVGVRTTRKVNASAINSIVEKTKGEGLAGTTAVVARAYLYLMLRNPTEAIAEINSVLPKVQDEALKRFAVGIRLRSHNEMLDMKEAALNVSGGATEAEVSDLRSKLQRDYKELVASSPGCWLVELAAAEYSLYTGASEELCNRFASIEKEILEYINTPIHVSELVATTDNTNEFCLIGFQASRARPGVRPEGVSAAVAEGMTNVMADPATAKVLEQAKKVFGGEVTEEEALELAMTLHEANVRHHFHDFFPTVTDHYDQWTSKAAQSAQQLIREALTPHNAGLKQEAIERIRASVPNKAFYDSEENLHALLRSAPKDRSIILSIREAFGPGPSTPISLSDQVVADAVESVHLAVVSSDTAAATGYARRGKEIAKALAKQLLYRTQVQKCVALAEMNHLQEAVEAVTPVINANEYVYMWRAFLARSRAYKGLGLITKADKDLKELNRLKQSLTERTPYEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWI8</accession>
    <name>A0A088RWI8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_300510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701086.1">
        <property type="nucleotide sequence ID" value="XM_010702784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWI8"/>
    <dbReference type="GeneID" id="22577105"/>
    <dbReference type="KEGG" id="lpan:LPMP_300510"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300010400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_300510"/>
    <dbReference type="eggNOG" id="ENOG502S46G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="252783at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="163"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="310"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="358"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="601"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="163"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="361"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="708" mass="76094" checksum="7086713FB4E95013" modified="2014-11-26" version="1">MSDASQRAAQQRRIQQLHERLELYNIADSHTDPTSTSAGGVGSAGAGGLQAGSEGMAPSTKPSRAAPMLSSPNPTPTSSPASSAFFFASSLLRRTADADVPSFTFGLQRSNGGPAAPSAAGMTEGSRASPTPQPHAQVQMPAPVPAPQLARNLAQEFVGSAASPIGASPARGASRSSVMTSGAAASPAAPGRPSTGAAYPKSATEAAEAVTTANTDSQRRTSSRFDRYEGSKTDGSEYDEYEVEEVEDYTEGYEDEEEDEEYTKEEVGLTLEDMLYRLHRACSSSSDHAMTSSSLQQAIAAATASSPLARDSSLASAPPTAAVAPRVASTATTTNSMGTTHPFLQQAAEVYRQRHLHKVTQEQQQHHSPFNTGHTWSTDEERSLTDTSTSEITGELDDVSESGSSSGTSSAAAAPKKAVAAANATAALQNDGLSAAAPAPLAVATAATRSPLDGASAGNALPSSALCFDQLEAAYRRLLVLQQGSKYVSERVGPECFPRPLPRQENAYALAEQRDLVVKRDTEMRAAPPAGATLEDLRQRENAAVEKTLGLLREKFDAAMKSLRPVIDREALIEGKRHMLKQRELDIAKQHEARLVVEREVAAAEQRLMERSEQLRKREEDYNTRLLQHDQEQKAAQEQIGEVEQLSKQVSSWLAILEERDRRLARKEKRLQRVQADLLRRIEDVTVWKRATQRIKQIPPPPSPPRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWX3</accession>
    <name>A0A088RWX3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_302280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701251.1">
        <property type="nucleotide sequence ID" value="XM_010702949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWX3"/>
    <dbReference type="GeneID" id="22577281"/>
    <dbReference type="KEGG" id="lpan:LPMP_302280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300027100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_302280"/>
    <dbReference type="eggNOG" id="ENOG502S0AZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="10"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="357" mass="38958" checksum="3CC0AD26D60D3A00" modified="2014-11-26" version="1">MSLLNRLHGARWCPLRQQRRRCNGVRGVFAGATLGRGDLVLSVPLRYCYIIQCCSPHDLGRSSASSFETVKGMQHLRRCNRGVALFPEAWMWLQRFSADADTDHVSLSCTISCEAAPGSMSAVPTVMSLTLSPVEATLATCVALRYFYAHALHLSAAARVAHRIGPPPNVLSDHFIASLPFEDYLQWGLESLYSDASSAEAHLCLEQLSCNLRDAILTHATNAEFRFLDESPSLLDSVILTSLYLVRSRVLRMPLLSSVSSKPDSSCSVFAPGLDALNHCEASPAAAAVVSAAQRSVVVRALRHITRGEEITLDYRQTGGGNGERSPRCFQTGSLLGKDEICMDDDCAARYLIDVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RX34</accession>
    <name>A0A088RX34_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_281860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700526.1">
        <property type="nucleotide sequence ID" value="XM_010702224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RX34"/>
    <dbReference type="GeneID" id="22576631"/>
    <dbReference type="KEGG" id="lpan:LPMP_281860"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280025100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_281860"/>
    <dbReference type="eggNOG" id="ENOG502S37M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273249at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39963:SF1">
        <property type="entry name" value="MNMC-LIKE METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39963">
        <property type="entry name" value="SLL0983 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="657"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="838"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="537"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="671"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="934" mass="98761" checksum="8A93B0A28CDDE07A" modified="2014-11-26" version="1">MGSDAPFLVLASTAIENEIRTYFPYMALYRRLCRGGWERAVDYFYREFAPGLTGPADDGMVSTPDSVAGVAASSAGVSLSQPKRRRKGLVEELQRGLEEFTATTFPLAQPRRSGTVPSGKQSEVPESAAAAVPSTTVEAGTELYTVTCRRCITHVTSTYPCWVLKGYVVLWAESVLEVECIAAREVVAASSLASSVAAEPAHGNTNRKDLLSQVEHSDVMDFPDSQAPNAPRPPLSPLFCTSLPPMGVCPLLHQLTSAFTGTLDCSAEGATASFTPLSATSSATTAPSCRQQGPISSSGTLPCAFTLSMAPVTQTVRLHSLNIVNSDAVSNTRPGSFVLQSILQPGWQTALECYPRHMVHFGLLVYAAWHASAQTWESVLLSGRACKGAHGTAENPHTGVLPSRRNQSGTALLPKSRKRAASPTPEVAVAKAVLSPAPEAGGEVHPTLLTELIPHTAHDAVLILGLGGNVLGQCLDALLPATVPLHIVEVEPAVLQACYEHGQFPAIDAVDGWRGELDAVRSCKTSKPASASHKRNTSSLSSEEAAETARAATSAARPTASLDIAAVMQWAAGLIRRRSATPAVFRAMGQSSLGLLEGLAAPPPAVPCSAKCAPRFRRRSAAVTEAPLRSQRGRREYVCFLQDAYAYLRAGAASPITSTTSRGTAHPVAPSSPQQTTPTKSAAHPRTPSAKREATNAATVEAAPTPTQYSMIFLDCYDPDRERMMHEGALVELCARRLKPGGVLLVNAHVLPTLENLRCDFLGYGFATVQALRVAGCTQTVVVCVAHDTTADRAPAVAERPTCSTACAPTLTEKRGRFTLRQIQLLANALNRALRLAGGSSSSVTGSGDDTGRAEASAAAATGTTPVSSLSCTTFLPHSVAPGFWFDAAWLKSCRRVATPPIKAARSSCEELASTTSSQACFIDVDLRVWEHHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXR1</accession>
    <name>A0A088RXR1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_291140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700722.1">
        <property type="nucleotide sequence ID" value="XM_010702420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXR1"/>
    <dbReference type="GeneID" id="22576878"/>
    <dbReference type="KEGG" id="lpan:LPMP_291140"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290015600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_291140"/>
    <dbReference type="eggNOG" id="ENOG502QUMT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270766at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="584"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="584"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="625" mass="68626" checksum="718A4C83AEB28BE1" modified="2014-11-26" version="1">MDFNPISIEEGGHTQRQNGVANATARVRAAGRGDAAGLLSQHASFGDALRACRNAFYYHTSWSVPYPEVPAVPMLYYPDEYKRMVESTMPLGIMQSELDAMQTGLLDSIPLAYYPLEPNALDEARQALRRAAPPKKRAAAAAEVDDATSSSSTSAANASDRARPPHGRLDPGDAEIASIVVDANEIQIRNLPSLTQVQRPLYTDIGLVPQKERHAARVARTQPTETKPHDAALTTEEVVRQWRLDVQSSFVQVSQIDSGFARFIGEVAHAKLGLDRNNVSHMRLTRALWALLYQDTTKRQQRKVWYAICHFSSIFSDTPAASEAAVAQLLRETEALGLSQYSTSWRPLLMEYTRAVSDYIAALPGGVEQRRENLQFHAKELDQLYTGNVYTNIKLDGKLARTSADRLKNTIYPVEVMPVYPSGYQQAASLGAAVMRLHDSEELDFLAERDASLHHVILPDAVLPKAAAARPNMLVGSCNLLVADDGDFANVQRGATIRYSVSTENTYQTLRQDPMSTASYLLRVGQVATDAAASLGANHDGRYVMYDRVGHRDVYQKTNHTDTNTLSRYVVMFTDMPAAAGASEATAGASSSGHLNSVKREREQVPAHEAAAETSEPVVQVLRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYF5</accession>
    <name>A0A088RYF5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_300970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701130.1">
        <property type="nucleotide sequence ID" value="XM_010702828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYF5"/>
    <dbReference type="GeneID" id="22577151"/>
    <dbReference type="KEGG" id="lpan:LPMP_300970"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300014900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_300970"/>
    <dbReference type="eggNOG" id="ENOG502QRP2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271830at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="931" mass="101818" checksum="31681D4016E892CD" modified="2014-11-26" version="1">MLRCSLATYGSYLLNQRLITDWWQAGQREEVHQAAKARLSAALEEVEKRSSSAPQSSAARVDEDGGPSFSSLGSRQRVDAPPHSPPLSLYEANGLVSTFVSSHNTQDLSATLQYIREQLREDLTPYHFHSLLRTFNYHHDVANALQVLEVMMHSGTTTLETYARMVDCVHCLSPPDVEARLLQLVALAQEAFGTHVMEDDTGSEAGTVAAYSFSGEGRQARETAADVTGVDPSYPSSDAATSKPAQLPRSAPVLSSLLYHCSTTSHRSTVASCVVVAIWIRAFGVELTDWDVLSVLSSVLTHTGEFPQFCAMFSSFDAYERGTVSVQAVIERLVLLGEVVWSGSSTTNEFMDEHVESSERGSFSDDKGKARAKPSATSTLTSLVEAMQASLRAAGVDPASAVVSLPFVNAQTNSMEQLVAATLLPLIQTGVGPHYYNAGHLFHALSLVQSSMGDDTGAIQLLQRAACEQQRCTLAQEALGMTANSRVSTGESSGRLTSFTEPSSSLGVTHASVPATREPYSVSVHHLLDMGTLLSRVSATTLRDVQRPFHSALRHMMAGLSGRPTEKPSDFSASPSSSWPSVVASCTPPVPCARDLVTVSSRETQFICTVSEARTVLRCAIDAGKAIGSHGRLPRSTQFMLMQLAELCCRHPPRNPKLTPAGLEERTKWGRYLDARDTSLALFGSAQHSRDSMKHLFYNDNQLPELRSEVVIAKDFADVHELFFGSASPSSLSQAELQASLRRTRTTLPHTGSSAAIVPRYLWDPAVYNPYPAAQLAINTCEFSMGPSGKGTQSPFTLAEIHQTDAILGDDAEGDFDGSEFFVELWQTLLDKTTSVGSNEVWYLQNTDMFLLLLRCLLHRLDWETAAHLTRKMTQHANYTYLMDHELTTIFREIGDPAGCLAFKVATKLFDGRITKDGQTKRERFHQEQFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYJ7</accession>
    <name>A0A088RYJ7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pumilio/PUF RNA binding protein 7, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">PUF7</name>
        <name evidence="4" type="ORF">LPMP_321840</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701869.1">
        <property type="nucleotide sequence ID" value="XM_010703567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYJ7"/>
    <dbReference type="GeneID" id="22577925"/>
    <dbReference type="KEGG" id="lpan:LPMP_321840"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320024000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_321840"/>
    <dbReference type="eggNOG" id="ENOG502SI8A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="278260at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF126">
        <property type="entry name" value="PUM-HD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="372"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="741"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="382"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="741"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="751"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="767"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO01069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="780" mass="85021" checksum="2D5B09C700E8BA6A" modified="2014-11-26" version="1">MPGMRLDFLKNPAQRVATGKSLPLKQVEAIVLYGKPAQRAKVVQKLLPAVYGLSLNKTTHHILLTLLDHCDNMDRVKMLYHVRRKLLDLAQSPVGNSVLQRMLEKMPVRQKKDIAEAFVLNVDEDEFKRLCEHPFGNHVAQKLMEVPECVEVVLPHFLPHLKSLSFHLYGMRVVSKYVESVADGCSRTVEALFPSYAEADPEGDEAAIAASDTLDKAVQSLFRFSEESLVLTALLRHIRTPVEVKDAMAAHLSEYAADYLLPPTPVQEGAAKKGGDDEEDYGLPDFGLLGSSAKLAGATNTPTNVHVYCAILEHGDDVQRADVWAALSTNADILHAITHTKGAVLVGVAAVRFVEAARKTLLDALLVSATATSPSNGNDTGSSTASAAHTASPSKPSRKASKRTTTTRSDEAAFSSHGDTAKSSIVDVATDPVRSVLLRTFVEVARDTVAEKHTQLLVDQAVTLAQNSVSSPVLQKLVETDLTGGFASALLAVLLKSVEFTNLVTHPAASFLLQSILQFSPEGVRAPLVEALSNYYAGHLHEALSHAQGSRVMQKLLAYAPDVTVIQTVHQLISDAAKEEEVVVVQAKCTNGSNTDAVEAAAAGHTAKTTEATKVSRKEQRVMNRSKHYEVLSHALLSYALHTHACYVIRALLREVRTRQLDRERKLLMNELKPHVFELAVSPWAGRVVLDAMMTVGSAQLADAMKNVAFLRAEEWLSDVSEKKRHSNSVDPTLRNILKRQREEIDKGVESKSTVTQSSGAEGKGAPAHKKKRLFRSVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZ47</accession>
    <name>A0A088RZ47_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="13">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LPMP_323010</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="13">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the CDS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="13"/>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701986.1">
        <property type="nucleotide sequence ID" value="XM_010703684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZ47"/>
    <dbReference type="GeneID" id="22578042"/>
    <dbReference type="KEGG" id="lpan:LPMP_323010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320036500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_323010"/>
    <dbReference type="eggNOG" id="KOG1440">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10260889at2759"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46382">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46382:SF1">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01148">
        <property type="entry name" value="CTP_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AIO01186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="470" mass="50885" checksum="B001D2094F75DD13" modified="2014-11-26" version="1">MTGEGTATVPSAKASPACNLIGLTNIQMRTVTICIAGPAVIAFGAYSLYCATLLACFAMFICGIEWNGVKRHLKVALLMSMGNAATSTSQSPHIEGEPLYPEVYALPVVPITLYNVLKHLGWVLLSSAAYIGEEAFLLMLEFYFLVFVVVTLVAHNRLKLNAEHALERLCQQLSFCLQSSSRGVVGHVGRCGGVFTAAAALNAGPDLSLANQRETKEALVAKAQRDYFLLTELQMIAERQPAEQLLDFCLDIFGMLWIAGLTTPLCVYHITNVGLPWAASTLISNFVNDIFALVVGRSLKALRERYGRIYDVTSEDPPASGAANQPGKRPLTEASRLMRVLLRSPHPLYPDISPNKSVEGAAAGVVMNAVSFAGLMFWFYRTLFAAPAPNIVNPAYQSVALWLLLGVIMGVLGVCGDLLQSLLKRAARLKDTGVIIPGHGGLLDRVDGMLLVFPFMHCALRIIMRLSSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZ61</accession>
    <name>A0A088RZ61_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_331510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702243.1">
        <property type="nucleotide sequence ID" value="XM_010703941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZ61"/>
    <dbReference type="GeneID" id="22578304"/>
    <dbReference type="KEGG" id="lpan:LPMP_331510"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330021200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_331510"/>
    <dbReference type="eggNOG" id="ENOG502SAGS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273646at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="567" mass="62335" checksum="EF23DEF75F73063C" modified="2014-11-26" version="1">MLMWRSRRAQGVGSGEGVRHLICAVSRRCTRLLPACCFVAADTVCRCCSYSTNFFQSNRTEPKRPFHFVETPPVERDQRSGALPRPSSISAPEVSAGIIAEWVPDVLGYHMPLGLRERSEPAPRSSLAEAADLKALTDAETRGTEHQELQKVSSTTRDTCESSQVGGGGGGHRDGHSGGPSFCGPLPNFATSPVFEWKGYLWQWRPVKVTPVAGAGHPKTSTVSAPLCHWERSPSQDKTLCSAGKENDLAEGVLGESPQDYYLVPFLLCPTLEVRAMQPLMHDSLRRELAAALSACHHQRRRCSEGAKQYRSGTRSCSTYPECKPQLWSIRMPTPVGELAIVSSKNSESDAVIKQSTKFELPTFSMIEGEPPMRVGERTRAWFDPETTHPTPPEAETWEAATATVRDAQGASTESDTVPYVHVFCSEMSTACCDSPLLQTGNKVLASPTPSPRDLSRPTLPIVRRNVVGGGLAELFLAVDRYAALIARGDLTLSAACWATLCDTKSCWVVQRLRVCPLEMERELIAATEAHKRWQQYAISRNRTLVGKSSHGICFYDYPSLAKWPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZB7</accession>
    <name>A0A088RZB7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_332070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702298.1">
        <property type="nucleotide sequence ID" value="XM_010703996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZB7"/>
    <dbReference type="GeneID" id="22578360"/>
    <dbReference type="KEGG" id="lpan:LPMP_332070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330027800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_332070"/>
    <dbReference type="eggNOG" id="ENOG502SI3P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267698at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="429" mass="44647" checksum="2416E266DFF6CB6A" modified="2014-11-26" version="1">MAEGASEGVLPTMRFFFPDDGVAPSMVDDSFVSLPASWSVESAAGTKNRYAAPPQPQRLEAVREAVTESVGDEATHTVARSGATLTVVASGPTHIAPVDRTPVKSVPCENASSSAMEHECSLAEALAAAPSSLGLLSDEESQRTAAPLSRFSDAEETKPNDMPGRFVADHSYPQPELLDGSIARGVAEVEAMATLTHSRQPSQRVPPASLPHSSHLPDGTPAAAVVPATPSLPRKPPTPLTPPPSVPCRPEAPLPIRMPGSDATSVALRKAIEEAEEVWTRGLDTECISNPEGRSAETGMSSISTTSSSSSDAVFFAEVTQLQQQAARLTEDSARSAASLQALTSGLLRILGPHAALSSLVGEQYSKTPLVHLPWFLIAVLEGLLNNNADADDEGGAALKQVEVAEKQPVSPRPCSDAAEIGSSGGHAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZG6</accession>
    <name>A0A088RZG6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">AAT25-2</name>
        <name evidence="7" type="ORF">LPMP_310560</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701445.1">
        <property type="nucleotide sequence ID" value="XM_010703143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZG6"/>
    <dbReference type="GeneID" id="22577482"/>
    <dbReference type="KEGG" id="lpan:LPMP_310560"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310010800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_310560"/>
    <dbReference type="eggNOG" id="KOG1305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28208at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF690">
        <property type="entry name" value="ACID TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="449"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="484"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="116"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO00645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="514" mass="55826" checksum="C69F4347655F10BF" modified="2014-11-26" version="1">MSGNRESLLDIHKMDEVELQGRRHSDHHEALAAQSVDMEPNWRDVGVVNETSKGRSQTPLFDFSEAPAKKTVDDIDGATESRDLSSAIVLDEAKGGGTKPRRNIFARVFDAIIPNGGLLSGTFNLACVTLGAGIMSIPSAFNTSGILMAVVYLIIITSLTVYSITQLSVAMQKTGIYSFEGLARALFGRGGDIIAAILMWILCLGGAIGFVVAIGDILKPILAHPTVPPFLQQKNGRRCIMTAVWLLFMLPLVLPKRVNSLRYASAIGVLSIMIFVVCVVYHSIAYGFKGGIRKDLATVRPGNAAVSGLSIFCFSYLCQVNVGRIILENTNSTTRKVTLQAILSCSFCGTLYFLTGFFGYAEFGPSLQGNILDKYNPYQSPIFFVVFIGLIVKLCAAFSLNMLACRTALFQVLHWDVETMPYWKHTLVSVPIAIAAFVLGLVVSDINIVFGLAGSLSGGFIGFILPALYVMYAGNWSLKSVGIWHYLGTYFLLISGVIAIVFGTISTVYFSFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZG9</accession>
    <name>A0A088RZG9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_331220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702214.1">
        <property type="nucleotide sequence ID" value="XM_010703912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZG9"/>
    <dbReference type="GeneID" id="22578275"/>
    <dbReference type="KEGG" id="lpan:LPMP_331220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330017300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_331220"/>
    <dbReference type="eggNOG" id="ENOG502S50H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="261906at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="147" mass="15676" checksum="36848B430CBE039C" modified="2014-11-26" version="1">MISGRSLLLSQNHLGCRSAVLLGGVAANLRGSFRPSTAAAATSHPQSGALTVSKRQYLGATVIPNLMTHCTQVGACTSLSTILYSPVGTAMAIVLAYNIIVICSKHVNYSLEITAKDYVQDQQLLTIMRYGILSCILLGMEVMFIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZW4</accession>
    <name>A0A088RZW4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nuclear pore complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_332150</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702306.1">
        <property type="nucleotide sequence ID" value="XM_010704004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZW4"/>
    <dbReference type="GeneID" id="22578368"/>
    <dbReference type="KEGG" id="lpan:LPMP_332150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330028800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_332150"/>
    <dbReference type="eggNOG" id="ENOG502QUX7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270884at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007252">
        <property type="entry name" value="Nup84/Nup107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003:SF2">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003">
        <property type="entry name" value="NUP107-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO01506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="787" mass="86708" checksum="44E1A2893939E197" modified="2014-11-26" version="1">MQEVYADAEQSDQYHPDAIGIESVQPHRRWFVSHYAHLQAFLQRQPVLRRANIICRWLESTYRDNSRHEPRLHGEEEVVLRQLILTYLRGGELHRAISAAVTYESCVHSCILSAAQLQTVQEPWFSQTALVPLFGEYAHGELDQAWCGNEYRLDNLSQLYEESLKYRSAAAAVGVQGSAATPTPNAVSDFDAVIGAALCGNLTVLENAFKMNGNWKDIVWCYLRCALVIAFTKQVMVATGASGEESGRPAAGAVDRSYAAFIEEMTGSGDNWAASFSQKLVQGLAARLQSGFLTRAPLEEQLQMRFILQTLTCMDGKGSLLSTVPSAVPASEALVGATEWFDIVPEEGKSEAARLITHVVLVQDVAYGETLSPHAVQVRAGASLATSLARYAVFLALLPRYPFDEGLRAVTAMTLRLRDPRHRASVYAAFIKAAREYELQRQNLSRSELEEQEARLVRQFVTADSDASVHAEVQQLLSQQIAVTELLTHNKLAEKLMWEAMHADSLSDYLTVLRRGLSACCSFWLTEPEPEVEAIADVSSILTRRVLVEIQRRSGLQEADYAGELTARAAFSSAPSPSASPVTELERSEATFWYVLSEARGIATEHATITAQLNAAKHTAAFAGAAALSNRTLIYQLTQDEAVLLCKLLEHTQRAVRHGGAVVYRDRQCLTAIVTLVRQLTEAVTLSMLSGVVEGDVEEESPDPRDELTRMQQVYGLMEELHIAGYLDPVLLPQQSASALYAQIRAMRVSYGQRVHKRQVVAALRQRTHGTAAEANRVGAVVPVGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZX2</accession>
    <name>A0A088RZX2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_340250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702453.1">
        <property type="nucleotide sequence ID" value="XM_010704151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZX2"/>
    <dbReference type="GeneID" id="22578529"/>
    <dbReference type="KEGG" id="lpan:LPMP_340250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340007700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_340250"/>
    <dbReference type="eggNOG" id="ENOG502SG0K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="257775at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="77" mass="8607" checksum="143DF434E9C211A0" modified="2014-11-26" version="1">MFLTYQVAPIWAMLVSIVTFLVLRRYDPVDLNEYAEKMHGIPPVACCSAIAIPLIILFAYNGVLKMGPKPPRSGTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S033</accession>
    <name>A0A088S033_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_341070</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702533.1">
        <property type="nucleotide sequence ID" value="XM_010704231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S033"/>
    <dbReference type="GeneID" id="22578612"/>
    <dbReference type="KEGG" id="lpan:LPMP_341070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340016300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_341070"/>
    <dbReference type="eggNOG" id="KOG0925">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000003">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000767">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001682">
        <property type="entry name" value="Putative pre-mRNA splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF261">
        <property type="entry name" value="SPLICING FACTOR ATP-DEPENDENT RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="40"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="226"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIO01733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="705" mass="79797" checksum="6236506805A314B4" modified="2014-11-26" version="1">MEANHSTRNRLTGRAYSSHYFTLLKVREQLPISAAKARIQKLVSQYQTLLLVGETGSGKTTQVPQYILELKPERRIACTQPRRVAATSVSERVAEEMDVELGEEVGYSIRFDDKCSEKTRLKYLTDGMLLREAMVDPLLSSYSVIVLDEAHERTVSTDILIGTLKELLPKRPDLRVVVMSATLEEKRFQEYFPKAPLVHISGRMYGVEVYYSKAPEANYVEAAIRTATQIHLYEGEGDILIFLTGEDEIETAVERLQNGIRMAEHSSANCHHGPVVVLPLYSALPPSQQRKVFKTAPEGTRKIVVATNVAETSLTIAGVVFVVDCGFSKQKVFNPKLRVESLLVTPISQASARQRCGRAGRTKPGKCFRLYTAKSFHSALQPNTYPEILRCNLGSIVLHMKKMGIEDLVNFDFVEPPAPETLMRALELLNFLGALDDDGNLTKEGSLMSEFPVDPEMASMLFHSPKFGSSEDIARISAMLSVQNPFITPSNDQRGRAMRCREQFYHPTGDHLAYLNAFNAFYEVNNQSTSWCTENYINPRVMKQAVNIYRQLVGILRRLNLPINSTYTAQQRHVQHEDAPAELEFANDVRRAIVKGYFTKVALSLPTKHQFMTLKDDVKCLLFPSTYLNRRPKFVVFNELVLTSNTYIRTVTAVSEDWLLESSPSYFAQDEFEGVTKQVFDDIFRRANKEKERRSKRTRSPTGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0R3</accession>
    <name>A0A088S0R3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_343700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702793.1">
        <property type="nucleotide sequence ID" value="XM_010704491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0R3"/>
    <dbReference type="GeneID" id="22578875"/>
    <dbReference type="KEGG" id="lpan:LPMP_343700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340044500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_343700"/>
    <dbReference type="eggNOG" id="ENOG502R1KH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268709at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO01993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="309" mass="34277" checksum="F5C220505C40E1A2" modified="2014-11-26" version="1">MGGVRITRCNPTLLDFVTWAIMKGCRLFQRVHITPLGLLATERIPEFDFVAVVPIEATQSVLSIASDPNIALKVSPERHGEPVPFWEDLTRGSFAFVGFLTKVLLTGQPRGVQSYLDVLPFDQAMPIGKVADAAQATKGYKEWTAPLVAQCKVEASDFDVVFRHAYCLFRRHAIPFLSTSDVGSVGHPYFQQSPFAQRGQGELMGMVPVMDLALHSSNPNAMIGYPDGEMLLWLAQQKKAAAQHEKGYFVMQALRDIEKGEMISVNKNAHFSFDEDTFEAWFGYPNASQVAVERAESSVMGRSQTEEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0V9</accession>
    <name>A0A088S0V9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribonuclease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_342200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702646.1">
        <property type="nucleotide sequence ID" value="XM_010704344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0V9"/>
    <dbReference type="GeneID" id="22578725"/>
    <dbReference type="KEGG" id="lpan:LPMP_342200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340028000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_342200"/>
    <dbReference type="eggNOG" id="ENOG502S5PP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="414075at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051181">
        <property type="entry name" value="CAF1_poly(A)_ribonucleases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15092">
        <property type="entry name" value="POLY A -SPECIFIC RIBONUCLEASE/TARGET OF EGR1, MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15092:SF46">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="694" mass="76526" checksum="EC3990782532ABDC" modified="2014-11-26" version="1">MEITNNNVGMLLPYMDTILRDCSFFTVDLEFSGIDHDRDDACAEAPEQAIRSLMRKPSDLYLAKLQDSKLYSIMQIGISVFTEVEVGDANGVSTANGATPSTVPSAAAHLKKEVADFLAAEVENYTAYAETTAVVERILSSANGSAKDFASAFKYLADQMLAVAQSLEMAARANSIRATEGPPLSSQSLPILWQRYHFLETLSHAVASYQIKSTAADVKVPLTPSTCYTVHTFSALMFPAATDTEVDVTLNIATAEFLAKNDMDFTRWVKEGLRFEPVKVAAAQLTKKVEAQLQEINLLTQPYTMLQGYKECIGRRLDNLLPLLPGELQLVRFILSLSSKEFDDPAAANVKQFYVKSLALIISFARGIVPESALPEYIYTKEKLYRAEMNALSAIGVTKANRRFVRTAVFNTWGNGCSSSLVSRSYGSDLLKTLLYATEVHRKPIVFYNGYTDVIFLLLALYGASSMPLNLQSFKSLAHRHFPSLFDTRILSCAEPLQGLGDFSGKLWNVVDEISKVSTIGPYVSFKFDSTFSGGCGSTQSSMTHNAAFDSLLTGKLFAFAKYGLENANTSVKVYENILSTYATLKSIYLVNRMDGMKRETAAVVYYISNKPALRVDIIRKALESCKITAVILFRGHGYTIQPIGAACQMPNLVQTMIKVLSAKVHEKVELYQIELRTRAAIKGERESDCTGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S171</accession>
    <name>A0A088S171_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_343920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702814.1">
        <property type="nucleotide sequence ID" value="XM_010704512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S171"/>
    <dbReference type="GeneID" id="22578897"/>
    <dbReference type="KEGG" id="lpan:LPMP_343920"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340046500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_343920"/>
    <dbReference type="eggNOG" id="ENOG502S8EY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271738at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839184" evidence="1">
        <location>
            <begin position="28"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="146" mass="15946" checksum="064E4B959FB527C8" modified="2014-11-26" version="1">MHRCLFPILISSNDLFFLFLSVSYSSSRKPARTMSAPSTSAADITEGTEDDMALRFLNHCLSNAVQVHYLVTSSLQGGDWQTSTLLGAEAQAYMRALLAAYASSSTFRRRLVSGDSLHYLQCLTDEATRADFVRVAAAPSFSFASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1B0</accession>
    <name>A0A088S1B0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vacuolar transport protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_344270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702849.1">
        <property type="nucleotide sequence ID" value="XM_010704547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1B0"/>
    <dbReference type="GeneID" id="22578932"/>
    <dbReference type="KEGG" id="lpan:LPMP_344270"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340050200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_344270"/>
    <dbReference type="eggNOG" id="KOG3232">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10266568at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="167"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="205" mass="23486" checksum="63D0676D54EC69B0" modified="2014-11-26" version="1">MSVDKLYDIQFQLKFTAKQFLKNASRCEKEQKQEMNKCKQAMEKNNMEGARIYAQNSIRKKNEALNHLRLSARMDAVVSRLDTAIKMKMVTKNMGQMVKGMDKVLQSMDTTKISKLMDTFEQQFETMDVTSAYMESAIGQSTAVTTPEDEVNNLMAQVADEHGLDIREQLNGDLQIKNANLTSQKEEKQVEEDELEAKFAQLRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1G2</accession>
    <name>A0A088S1G2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_350710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703008.1">
        <property type="nucleotide sequence ID" value="XM_010704706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1G2"/>
    <dbReference type="GeneID" id="22579100"/>
    <dbReference type="KEGG" id="lpan:LPMP_350710"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350012600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_350710"/>
    <dbReference type="eggNOG" id="ENOG502SJM3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266174at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="725" mass="79126" checksum="A0010C3C0BBD636F" modified="2014-11-26" version="1">MRSGTREGLQQGSQSSSVLPSLSPTSTPCVPSPEQPSAGVEAVKYALAPQGLASPLQFSIFYTEEEHRVRLETHETDERRCLFQAHKAVLSVYRMWAAEDADADYGDGDRLLLPPSRRGDDMSTRFLEDRFCSSTSNMPSRNAVDPKAQVPPLATVTTANAAAAGWVRSFLSSSIDSARGRRSVGVDQKGDTTSCLLVHRSTTPSIMYADSDAEVRRASPDHQPHPQTSHNSSPAASRMLDYSSMQMPETVASLMYTSSEPPSLVYQAKLFSPWRTARTAQQDAAAQRAEGKADVHMEPSATQNYSLSRPQRDSRTSLVPHLVSTLPAAAHRASTAASLYASSEALWRRSVLESRLPAKTAVPCTDLLRGAALPAARISAATQDPSQSLRAVSPPGVGSFSSHSSAQTEGRDASHATSSRVWNASVNRVSTSAASHHINPTTDDSRESRVARDVSRYTTSEAFRLRHLAALSSTSSGGVLRSPRDGIATKQKTLQAAQRPEDYHRERLSSYVQYKRFFDAVYGEQSSSPLSVREPDARQSTAEQASAVSPRSMQRLSSTSVNVGHRDKGASSWARRLPAASCSYQRVRSPKLIARCDVQQPLPRALTPLSDALTTFSAWAPKPAGWLTGGPALSTALADDTFFTGRLTRLLTLEKLCRAELQRRCMEDQSVLLHHFIVEGTAALQRSRRAIVPLNRHRQRTSEGRTEAYRLAPSWTFIANKVNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1G5</accession>
    <name>A0A088S1G5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_030810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009372">
        <property type="protein sequence ID" value="AIN95316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701024.1">
        <property type="nucleotide sequence ID" value="XM_010702722.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22571947"/>
    <dbReference type="KEGG" id="lpan:LPMP_030810"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_030012800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_030810"/>
    <dbReference type="eggNOG" id="ENOG502S244">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="246708at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="728"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1083"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="728"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="743"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1428" mass="153198" checksum="9F389861D7AF7253" modified="2014-11-26" version="1">MTAAAAGTSQSGPHARFIAETTQLLWGGDYPSWIVQQWVRWGDVGDDEEDEGDDDDAVVAAESDVCSSTSGNRAQTADDATLGREGQEGSKHIEWIEGTASAVVSDSDAPVTATSPSWTLVMQQAFEALQLHLPLQHSHPPPQPQLASTDEAPVMTLAKHLVQDAPLLWLRYLLVPMYTQWTQQRAVAPPDAGATTPTATAPIPSSLSPLQSVATALERDGAVTMHKLLGALGTASMSEALRKEQSWSDDLVELVTAAVAAPPSAAAATLKVLHRRRTAIQDQQRQHTGEMLYFTGTLAKAAQSFMVLGQGGCAILTALIMRLLGRAKAAWVEWASRLSEADVQGAAQAIFCSDAHETRADCNSTGDVKTEDDAAGKEAPAKKPVQVEPSLQRAASFSDDPRTTPAESFAALRAAVNSTAQRQAHLVWRCWYILYGYYGADLYTNEALARALEEDDLEKAGVRRMAVAQQAHWRRLRLAADVKQHALSETHWLWCSTLLASVETTLTAALSEKCADGHVPARTCTRASTTNATDAPPVYTTERLYRRLLESAVCVFTAELRNTLRVHGEAALALRSGGLHNATATVPSALQAVAHNVVALQDVFAQCLLESLRQAPTAAMSPHQMGSALRTQAGAYLWQLYPTLLRVQVPEEVSWMCTTGAEQGGDGVGASHTAEVAAGQFAEQFQRHWRRRGRQLSAVMSDAFYCTEQMLTHERCYATSPSLLPSPSSNAAPLTAAASVSKSGGGNGSSGDGVSGRNEADDGTMVARLLAAIVHRPAEEVATSISTTSSSSSSANNDAWTAALCDVAADFYALYDQSCFFALRPERQRLFTLSVQRLYRLLLSPLDGSSDGSSPSQGDASGSATKTTLPLCQQPLVCILRRDTRLWMLLTHGTLLQLERRGRMAREDETLLASYLLPLLVLLGSRHHDGEFERGSADSSLLSTAAGAAPVWADTTVAEDVLLLLASGLASLPWDLEELYVTVQRHTALYLRHSTRRQGRLSADRAAAVTVMAAWFGTAELAALSAAPSSPTTAVASLWDFSGVSEVGSPTARSDTGPAALARETAQLDAQCRRDDPLLPHREEEAASTSAVAGTHDPKLTAPPRLSEATVDARFAEALARHGRLASVSLSSAPCGLLMVVGAYRSCGRALHSLRTALEEQHRMAREDEVGEFVGRSVTFCTSEDIAAFRGLVMTVHSCVFGYACQPRGLLRLWLGYLQHLFGCVVPRSVLPLSGDATRNKGDDALVLMPNSWQRRHLTTSLFGAQVYCTGWRALQHDGEPASQTRLREVLGECLANLMLLPYSHSLVNANCGDNEPKPPTAAAEKDEAAATQAILQRTLPHAVLEILCELLYIPVEDSRDSATNGKNDAAVDAAGTAIKDSFLGLAGLLAFLRRLELLVVPGSLQDPRLVSLLHHVYEAANTSALGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1V2</accession>
    <name>A0A088S1V2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_352460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703183.1">
        <property type="nucleotide sequence ID" value="XM_010704881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1V2"/>
    <dbReference type="GeneID" id="22579275"/>
    <dbReference type="KEGG" id="lpan:LPMP_352460"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350031200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_352460"/>
    <dbReference type="eggNOG" id="ENOG502RXWJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="444540at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO02383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="38819" checksum="07033D4DA2D9513B" modified="2014-11-26" version="1">MLSEGEYHLVAVAFQSMDPNNTGLVPLSEVKKRYFAHEHPRVKEGSMAPSAARDTLDYHFGVCAADHGGSITFDEFLAYHEKIADEAYDEHVGDVAAFTEKTIMKLWRLGDLLLPTGVRPVFPVAQPPTGLYASTNMTLVWVEPRQIDASPASGQQSPSIGGTATPSINAYGAVHASDLFVLRGVKDVVRSIFARGDLPEELQGYFAYPEELTGLAVDYVAPRVSIQRWYDFTWEYAEGKYCGVEGIISIRVDLESLPAGLRQFVCDHATAVSRGTTWIQTRPMVNPMYKKTSSAYGYGVNEECRKIHRWKVKTFEGKQYGNQYHGLCGKYFAKMKEPLKCSTTTGMNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S275</accession>
    <name>A0A088S275_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_352170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DENND6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703154.1">
        <property type="nucleotide sequence ID" value="XM_010704852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S275"/>
    <dbReference type="GeneID" id="22579246"/>
    <dbReference type="KEGG" id="lpan:LPMP_352170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350027800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_352170"/>
    <dbReference type="eggNOG" id="KOG2432">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10265409at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024224">
        <property type="entry name" value="DENND6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13677">
        <property type="entry name" value="LD41638P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13677:SF0">
        <property type="entry name" value="LD41638P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="3">
        <location>
            <begin position="1"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="472"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="472"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO02354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="897" mass="98363" checksum="046E3AC1F4FFFE1E" modified="2014-11-26" version="1">MPDCTTAAAQSFSQTVAPPTTGNTVPELYGAAFYRQKHDPNVPRCYVQQVLVLLSHLPYYNVHEIILRVVAPRFCQCCPLSPDTGKVPVSSLLIPSPEAYFEFDQSYSAEYYTQEDVLCDAMMELAQWPSPHPQVRYTVTLLQQALVFITPAHSQRQPSRATRSSCASARSAMSVDSRVEFMEVAQGSARYRRSTLGSDFLPLFKLLGGQLHHLTYVWELVIRHEPLFILSNTPCMASAVAFSVASLVLPIEFNGMLRSYFTVQNDDFSRLSRMGKVLSFPTNEVLIVAGTNPFLLRSFSGWPSLMVVMDRNASVMTNGSIVPPTLSGKACSASVVTEGASPPPQTSLLHRQQPNAFTAASLVGPLLRAVQPEELRAKTPLLSSSNGTHACTASGHEPLSVPVYSLTSTTSLAGGLASVPHHNGLHAPFVGAPPNLSSLSSNGAAVSPAHLSSRQSIFSSTSSYTADPHTTYSARTSVNSSPSTLCSSRDSAHNVKGMHRTQRSEDEGQAATHGTTNLYEAFPTQPSDSADSCIVQISRGRARTCYDSSDAPLGAAAHLASTPITTPSPVASSITLFTMDHYKTTVESVRAAEHQRRTSAHQASSRNELQKHLHNYFDSSVHFLLNHAEQTQMLLKRLQMVSLLDADAQRASVSLSLTQWHGNARTAPVPITAAHDECCTPLSSLLSSASTSNSPRHHHADTTAATNGITSCSHFSVADDMVRKFFRSLTSEFLTPVTSWFQRVTAPYTAFHLCDRALCDALLTPSNFLDDFARRHHEVAPSMWTQRHSYSKYKVVYERFAHGCLFKAYVLQLVDENLRQQMADFQVEDWVARVPSDADRIDLLINLFNTVQRELNETLDPDVLFVTSATSVLASMAVVLQQPHREQFMLKIGELKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2A9</accession>
    <name>A0A088S2A9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_060470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703928.1">
        <property type="nucleotide sequence ID" value="XM_010705626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2A9"/>
    <dbReference type="GeneID" id="22572253"/>
    <dbReference type="KEGG" id="lpan:LPMP_060470"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060010400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_060470"/>
    <dbReference type="eggNOG" id="ENOG502RYJC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275837at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN95606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="315" mass="34723" checksum="B9B0EDFBD1065A0A" modified="2014-11-26" version="1">MSYIPRNHYLVVHDAIRRLLGPNAQLAAFVKAKRAFQCDMLVNDARTDPNELIRAGARCSVGGIGDDAAARAGVAEFARGLQGVLGICDVVTHTRRVDVVFRDRSLIQLALGAAKSDLPYALNTGSDVNQEPDWRLRNRLRISLGYDEELFLAQCTRSVNVAARILEKCAFDSLRHSSMINTNPEMAAMYEASGQQWQAVLPPVTYWQAHCYALMKAYPCRHYQQIVATVEHNYAAYYGEFPMANPYCDGEDLNTIQVVRWLCEAFNAGVAMSRMASARSLVASDEGQTVFPAMGNGDAEKDATIMGNTTDGRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2B3</accession>
    <name>A0A088S2B3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_352620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703199.1">
        <property type="nucleotide sequence ID" value="XM_010704897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2B3"/>
    <dbReference type="GeneID" id="22579291"/>
    <dbReference type="KEGG" id="lpan:LPMP_352620"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350033300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_352620"/>
    <dbReference type="eggNOG" id="ENOG502S1D1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="244729at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="910" mass="99130" checksum="493DD50D34A610D7" modified="2014-11-26" version="1">MSSPKMQRDAASLIPLSQLLAADSVSGVLAYLVQDTIVDDPDARLQALSAVFAHISMPPNRECAVSASALGADGTSPSSSTCVCMHGARWKWADVVMRGVTDPWSRIRSLAAPVMADLLDAEVDLVLQRQGSRASAHFSPSNSTPRSSSVTTTTPESVSAPLDYVWNQWRGMSLWYEQDGIVRLLVKLYSRSGTPAGNALRTDEAGLRCLLFNVIFPALRNPQLPVRESAALLLGILVDRRSPTSLSPAIASFAVDHVCRSIMQVSSPVRSHSPASSVPLEETRVLEGNLLALNELVGADVIRVEDVGMMPLLLRLSSYPAASVRQYVAQILRPPSPCVFTYLMQRLCEHQNCMPQHAEGDGDSSSSVSGGGDGKNEDDDGLSWQRLETLMMALQQHLLYLHAMPATMQDLFHLIPNTEGILTPVVFATSLSVVFQATHSPRFEVARMGLQLFPLLLQLLLRFCPPVALSGVCEACCGPDGCVQAELNRLAACGDVETLSKAQAYVATFVVPAMWWFLTIRRLVAEVKEKMPPSPTTMASGETRAQVENVVRPYATLEQVRFASQAHLSKEASSSAAPPQTAATCALLPLATYFVTVMDPEEWHRCVNELLEPSWWAGLLADPARREQARVGPDFVRAVHRCGTSDEMQRVVELVPTLTAALADAPTHEQCLLIAMIRVAVEMRTASTVAMEEQALSFLYREAYAAPALAEGGDAVPLGHVWLKHFMPTHEAIPTAVLWGEPVKARSESVTLAESDSVVFEAIEKSCYQELYTSPRTEPVVLRELQALIMSLSRPSMSKPSRTHLHWYAAALAAVFGRLEKVCPQWRETAAAPTARATADASGCEDAKCCEDWDDDDDGAVQGIYVAEEVRNARAVVSVLRERAAAWMETRHVAAAEDRFRTDLTVLAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2L4</accession>
    <name>A0A088S2L4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protoporphyrinogen oxidase-like protein</fullName>
            <ecNumber evidence="9">1.3.3.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_061270</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="PLoS Negl. Trop. Dis." volume="10" first="E0004326" last="E0004326">
            <title>The Dynamics of Lateral Gene Transfer in Genus Leishmania - A Route for Adaptation and Species Diversification.</title>
            <authorList>
                <person name="Vikeved E."/>
                <person name="Backlund A."/>
                <person name="Alsmark C."/>
            </authorList>
            <dbReference type="PubMed" id="26730948"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MHOM/PA/71/LS94</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.3.3.4" evidence="9"/>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KM411735">
        <property type="protein sequence ID" value="AKK31184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704008.1">
        <property type="nucleotide sequence ID" value="XM_010705706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2L4"/>
    <dbReference type="GeneID" id="22572333"/>
    <dbReference type="KEGG" id="lpan:LPMP_061270"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060019300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_061270"/>
    <dbReference type="eggNOG" id="ENOG502S4T4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="260902at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070819">
        <property type="term" value="F:menaquinone-dependent protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004729">
        <property type="term" value="F:oxygen-dependent protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00853">
        <property type="entry name" value="HemG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026816">
        <property type="entry name" value="Flavodoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044264">
        <property type="entry name" value="HemG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052200">
        <property type="entry name" value="Protoporphyrinogen_IX_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008316">
        <property type="entry name" value="PRK11104.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38030">
        <property type="entry name" value="PROTOPORPHYRINOGEN IX DEHYDROGENASE [MENAQUINONE]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38030:SF2">
        <property type="entry name" value="PROTOPORPHYRINOGEN IX DEHYDROGENASE [QUINONE]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12724">
        <property type="entry name" value="Flavodoxin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Flavodoxin" evidence="8">
        <location>
            <begin position="9"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN95686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKK31184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="231" mass="25619" checksum="FB1E9A23AD44895D" modified="2014-11-26" version="1">MTSQGPKYLMLYSTTDGHTKTIMDTIAKQLTSETLARCDVVDIKDGNSYVLSDYEKVLLGASIRYGRISAAFMKYLKQHHGELSAMPSAFFCVNLTARKSDKNTAVTNVYTRKFLDQSPWSPQLTGVFAGALWYPHYNFFDRILIQFIMLVTGGETDSTKEIVYTDWAAVRCFASDFAALPLTVSPQQKLVVVKKLTGSLSSGNRTRWVLAIVGMSMAVLVGSSIAAVKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S398</accession>
    <name>A0A088S398_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chaperone protein DNAj, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_344490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702870.1">
        <property type="nucleotide sequence ID" value="XM_010704568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S398"/>
    <dbReference type="GeneID" id="22578954"/>
    <dbReference type="KEGG" id="lpan:LPMP_344490"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340052900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_344490"/>
    <dbReference type="eggNOG" id="KOG0721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000100">
        <property type="entry name" value="DnaJ domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075">
        <property type="entry name" value="SEC63 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075:SF0">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="134"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO02070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="491" mass="56046" checksum="B68020462FD2614E" modified="2014-11-26" version="1">MAEGGVGGSDESFISFAFAVTSVILIVLYIPWMIRKTRRLVFYHQSTKKERASMVSPLVELWDSATYIPRVLYALAQDPAAVVAGAKVCNSEKVFFLRCVMPKFLKFVIRPRILVPMLWFVLFSSAMYASLTFDPHAILGLPSSASTADIKKTYRALSKRYHPDHNKTEGARELYVQVRRAYKALVDREAFEEEERQNAQEFAVGVALPRFLTSREHDGLVLFGLLGLLIGLPIYIWYTFTNDKKVPRLLWHIRFDKERVEHFLLHFGIPADPKYVARRESRRAILRILIALNTVPPNVREDVVNSFPPLPDFVQRCIDADKNAALFRNLGLDAKAVGALQSYLAVNGVKIVDEYEAAVHLNGEEPKADDFQRVSISAYRATRYLFQQHTVQVEHALEELQVAMGGNVPSAKKLLNLHEELYDLLDMVYLRSEKPNKQLVMKLIAMPQRVSDIVDAIEPEMQLVYHRYFKSYMNHIQQQQRAARGGGAHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S528</accession>
    <name>A0A088S528_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CCR4-NOT transcription complex subunit 10, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_356260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703555.1">
        <property type="nucleotide sequence ID" value="XM_010705253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S528"/>
    <dbReference type="GeneID" id="22579654"/>
    <dbReference type="KEGG" id="lpan:LPMP_356260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350071000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_356260"/>
    <dbReference type="eggNOG" id="ENOG502QQZ6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276078at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039740">
        <property type="entry name" value="CNOT10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12979">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12979:SF5">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="557" mass="62216" checksum="3F26F2B04C05AB18" modified="2014-11-26" version="1">MAEVFEKQLADAKTAFYADNYAEAERVLRGMPQEDLKVQHNLVITRYLQHQLSSEQTLAALRASAEGTGEDPNMKAPGLMLQYEGHETAVYNQAVLYARSGQAHEAVLLLRRILENAQEIALSTLVYSLCLFHTLTKPIRKTMSRMSSRHDEELVQTVLTSNMEKLRVVPELMKLVEAAFADSSGLHDVFSDVENDQVKQAVHLNNLGVFSLSEDKLNVASLCFTKAEKTAASKPAGQHILRSIQYNVGLCALLREDYEGALHEFLSLQDSMKASALFWVRCAEAAVSCVQQGARKQCRADYERQQNTFSEMLQSGKVYSNFEFMLLPSATTVPGPATIEPSRETTEKTALEQIATAAVQNALFLLVPKGHTFCSAVEAFPHEEALLQYAMLYWVALELSRRNYMAAAEAGQEMLNGHERHLLPPNLHATLLIYVVEALVHLNDPDRAMKVLRRTSLSSLVSGSNNDPVDAAQRSRVEALFVNLTISHILTGSWNQAHSIMESLLRKIYEVAPAGTAEYTPERDTMFTYCILEVFLELAQGNQEKAAEWMLKITWSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S5H1</accession>
    <name>A0A088S5H1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein phosphatase 2C, putative</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_150170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697394.1">
        <property type="nucleotide sequence ID" value="XM_010699092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S5H1"/>
    <dbReference type="GeneID" id="22573433"/>
    <dbReference type="KEGG" id="lpan:LPMP_150170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150006700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_150170"/>
    <dbReference type="eggNOG" id="KOG0698">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000075">
        <property type="entry name" value="Protein phosphatase 2C, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="136"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="406" mass="44635" checksum="A57D1A4F0C3BBDDC" modified="2014-11-26" version="1">MVMKMPVNKKSSNANGSGSKHGNGHKGVVVKVKKQAVEEDFEKFLSDLSKTTQHIGKERKDRLLKEERLREDQRKKHADLAKQRSTNELENALINRQKRMQLQQLLAELISAQRPFGSKPVTDFHGETHTDNPNFDVAVGDMQGWRAQMEDAHLVNVNFLSASADRKEGLFGVFDGHSGVQSATLCSRIFSKTAERYATLVGDQHHTIDFQNTFLEVDEHLQAALGDGGSGCTAVIVYVSPEAITCAWVGDSRALLCRSGNAFDLSHDHKPDVAAEKERIEAAGGFVQDNRVNGQLAMSRAMGDFVYKKDKQRDVAHQLVVAVPDVITTKRSDTDSYVVIACDGVFDVMSNEELIDFINNKKASGMSNVDTCRSVCNRCLAPSSPEGGPAVAEGTDNMTIMIVDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S802</accession>
    <name>A0A088S802_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">asparagine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Asparaginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_202020</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Asn) + L-asparagine + ATP = L-asparaginyl-tRNA(Asn) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9659"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="3"/>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698403.1">
        <property type="nucleotide sequence ID" value="XM_010700101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S802"/>
    <dbReference type="GeneID" id="22574411"/>
    <dbReference type="KEGG" id="lpan:LPMP_202020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200025600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_202020"/>
    <dbReference type="eggNOG" id="KOG0555">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1148">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1931232at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04323">
        <property type="entry name" value="AsnRS_cyto_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000040">
        <property type="entry name" value="Asparagine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1290:FF:000002">
        <property type="entry name" value="Glutamine--tRNA ligase cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000528">
        <property type="entry name" value="Putative asparaginyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1290">
        <property type="entry name" value="Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007639">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042558">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_N_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042559">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF16">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04558">
        <property type="entry name" value="tRNA_synt_1c_R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="578"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIN97696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="895" mass="99719" checksum="82853EAEA88F3C36" modified="2014-11-26" version="1">MHAKGAARLRQHLAARQRMCLLSTWPVWWVAAKLTRGESEAMGWRATLQMDVEIIVEKLVGPASQIMARRVGRAVIDAPASAATSLPVAPGREFTVRRCSLSVPGSLQSPPPLRVTSLPLCGRAFCASTCTIPSAAPRLATTSSLALVHQLSFFSTSLSRCPFLFLALPHALVRHRRALPPHEHRSLCLLLHTSYRAIVIHHQSVLLFKTSDSQGPPRKTEGEMEDEQQRAAVIAQLKTVVGLDDKGAKDLSSKPARVADVLAFFAQYNINEASPRDQKVMLFNVWTKVKKLVHRKPIASFILDGQLDSTQKVDAAIKFVNATECEGVDTAAMLAECGVGVTVSPEDVEKAVAEVLATEDASAVKAKWDKNPNMMLGQMRRVAALRWADVEHVRAALEKQVPVLIKDIVVAAKPTVALPQAAKEETAAGPRKGVEVCQQNSNFRAVSQGLPRTAIGELPSQKESACVYVVGWAHRVRHQSRMSFVVLRDGSGFIQCVFDGSTEPFHRESCIAIRGTLRYEPKAKSELQPPMELHVHEYAIVGNSDGTIETIITAESSVDKLYDQRHIVARGTVASSVLKVRHELLRAFREYFWSRRYYEVTPPTLVQTQVEGGSTLFDVLYYGESAYLTQSSQLYLETVTASLGSVYCCLPSYRAEKSKTKRHLSEFTHLEIEYDVCSFEDLLNHLEDMICTVIHTVIERAGNMVAMLNPTQLINSNGDVRDSTNYKFTPKRPFRRLRYADAIQFCNENGILNTETGKPFEFGDDITDQPERAMVAQMGEFVFMTHFPAQMKSFYMQRDPADTTLTESVDVLVPGIGEVVGGSMRMYKYDELLDAYKREGLDASTYYWYTDQRRYGGAPHGGFGLGVERLLVWMLNLDNVKDACMYPRYMGRCKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S8B4</accession>
    <name>A0A088S8B4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_203410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698543.1">
        <property type="nucleotide sequence ID" value="XM_010700241.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22574552"/>
    <dbReference type="KEGG" id="lpan:LPMP_203410"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200040500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_203410"/>
    <dbReference type="eggNOG" id="ENOG502QW66">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272744at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1254"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1353"/>
            <end position="1376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1376" mass="151000" checksum="514F3652D710045E" modified="2014-11-26" version="1">MRGTRLWWLRVSLVIRDGAHTTRMETLVRRWADLDAARPATLTGLATELLRETIASLQAPAPALTSSSVSLPNLALSLLSSPPLLLTSRESAQRIWRSLRRQRVQWQDAMELLPWQLLAMTPAQRQFLSPHVSRTPRRVINLTLAALDMHEDAALVQQYQSLKRSTYMVEYARLVSAALRERPSLPSGLLPIPYGVMLHGYTLGRRSPQDARMALAISKHMTLLGRAALTREAEERLVLSHARLEGFTGQWQSALGIVRHSRAVRLSAREGVVRYVRSLMTRQTDARLTTAAPLAQSLSSLVSKHCNPPAGSWDNRTAPAGLAAKVPLRHEDASTDWVNALRVFLAKEPQAQTYPSALHLLESLPPEVRGDRAYLLLASTVLHCSARRMYAGTLTRRVVSCITSADWTMALVLACAAQCYDVAAPLIPLVTKSCSRGAAGVRDIPPELRAYVMTMEGLEQEERLAASASAFLSDTAAAALTYPEALAHALTATSPATWRTLLLFCPHAGPPSRLRYFLLAACDESSGDATVFKRTSENSYTRSHIECCTFQSCAASRLVCAAAELRNQQYFFKVIPASVRAHHFEYSPLTNAPTLELKSEAEPRAVSAVTAVDRTNAAVALSNSVTGAPVEPTLQVQSTMLARVRLQAWGNQTAMTPEKCTQLLADVSLYLRATHMVEGVALSARQKPRLTEEVFLKSIAALAASGVVQLPSTERFHWPLAVFQAARLLRVPVDASLMVAATRTIPSMFVDRARLALPSILGAHTLLGDWRAGLQLCTRLLRKKRDGELEIDADPLHAGKPQTHRFTAPPPTFLEAMAQVGYASPPAVAVRHWKTLEAASSTPLTLPQNEGPCPLSLLLLELQQFQDARQLCEEVRHVSERQRQGSTQRKLNCLSRRRMLLGAAFCLLNSEAALRRVLRASRKEKATATDVDAHGLQRLLRVLNSTDVVQVLAAEAREGRCAQEHWLCEEMSRADVAADVVGYLARLRPFSTTLSALLFFRQAAAAHNAVGCLKGLVRLAERASECPYTDVLLLSLLRLLRLFLSHDGLLSASVVTCELTEDKTPVALPHPTALALARKLFNRMQEVQRLSLPLKDARRVLRQASDTHLPVVHTVAEGTGVASTAKSPVAPCAVWVVLGVLHSTVSNVLQVPVPASFTSHLLSRVVEMNGSSDWWAALHFFKNLRHPTLQERGLLVRAFRHCGGAATPILLAHRRFLRDCPELVVVWADEASGPSKWLQSLALLEHAQNLERRSTAAVAETEPDTGSSTEPAPAPALLLSAAVVSIIHSWNADERLRCGELLRRQGFIETEPTKNGKSLDDARVKKMADTRAQRQTEAILKLLREKPSVAVPFSNASPPVFNAAYPGRSAGHQNRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S8D0</accession>
    <name>A0A088S8D0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ family chaperone protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_203610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698563.1">
        <property type="nucleotide sequence ID" value="XM_010700261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S8D0"/>
    <dbReference type="GeneID" id="22574572"/>
    <dbReference type="KEGG" id="lpan:LPMP_203610"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200042400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_203610"/>
    <dbReference type="eggNOG" id="KOG0714">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000190">
        <property type="entry name" value="DnaJ domain containing protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050817">
        <property type="entry name" value="DjlA_DnaK_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="617"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="691" mass="77203" checksum="750634110E7EB41F" modified="2014-11-26" version="1">MHRPTRAPFRLAHVRGSAVADAPAAVTLAEARYISQTPPRLSAPAMKLPELRTPQTVLRSGHADVSLYVSESTTLTEDTRCMIRRSPRAAEPPAAKGRPYLPSSLEPINSTAQLLNSSKLLSGDGATTLTPHKDVAEDQPESCLSYVSAVESLLSRQQYVDVYFVVSSLLTTDNGAAKVMEAEERRRLRLLSYRCLCSYALIRFKECCEDGRAALTLYRHLQDKKSSPSLEMSDERLHSRVVQALLGALIMREMYNDVEELRLIVPPLMDTSSEPMSNEFFHIPPPPWLEAQESAIPFLASFRRYVAAQRWSEAAQTIDGSATAQSWVKATPLCAMFAFVRLELHDPKAARALLLPYLASLPEPPSWEALSTAPVEHAQLWNHFSSHYVFSTTLLAKASFMSGSAYLNISAALLQRVLRLNPSYAPARLFAEFVLSYEAQQQRIDAAMSANDYPKVLSVTAEMLRMPEVTRLVHAELYLVRTQAQWMRRQPLEVVHEASRCVQCDPKCALAFRLRADAFAMMNREAEATADRAVAMHLHSKVDAVFDELRVQRSRYNTTQVEASAKRHSVPAFTSFQSASAPPRAPPRKRFCSSTRRSDAKSRKCANADLLLPGLRTHYEVLGVSSDAPEVEIRKRYRQLTLQCHPDRFVSATESNRRAALEAFQLLGDAYSVLSDVQLRAAYDVGLLNLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S952</accession>
    <name>A0A088S952_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_210610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698848.1">
        <property type="nucleotide sequence ID" value="XM_010700546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S952"/>
    <dbReference type="GeneID" id="22574883"/>
    <dbReference type="KEGG" id="lpan:LPMP_210610"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210010800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_210610"/>
    <dbReference type="eggNOG" id="ENOG502S1H6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273217at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="463" mass="49138" checksum="20BC0002A2A991FF" modified="2014-11-26" version="1">MDVFQATLDELQRESKEKITQAQDTASAAVLQARVVPHRIAVAMAQRFTTDRVESCFPILCLLDATLVRTASASPSTSSEADQALAAVLTEFWTLAPAAFASIHGAGQPAWREKCQRFVRRWKQRRLVPEPLITELLMAMESGSVKTEAAEVPRATRVSSDAAAAAVASSSSAVSAAVTTSGQPSLSTTITATGATTTTAVPPSASYPVSTMSFTVAQARAFRSTLQACLSALESLPPARAALYFELVRSQHFRAPSHTSFAFFEDLLKELRREVTMVSSSSSTNQAAGAGTKSDVDPASSGHAREALGKLLDQLHNSGGERATGLSAGGRATAAGVAGVGAHHSATTAVVRYVNSIFSDIYAKQPLGQRGTGFGTLQRKAGHGGPSGSSTSSAFYTSYYPKAEANAQRPFRIPPARQMQGGAVRLHFPRRQEWVSVQDMADISQYASRGITDRGLKRAREDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SA02</accession>
    <name>A0A088SA02_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_230190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699178.1">
        <property type="nucleotide sequence ID" value="XM_010700876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SA02"/>
    <dbReference type="GeneID" id="22575223"/>
    <dbReference type="KEGG" id="lpan:LPMP_230190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230006800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_230190"/>
    <dbReference type="OrthoDB" id="273354at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="216" mass="23761" checksum="7460001638D1A4A5" modified="2014-11-26" version="1">MGSKTSKEGTALNPEVVDALYREAYAAGTIDADMYHTSQREVMRQQDAMVGIGACMFSAWMACVYGRTTGMQAAEEAAARRFDAQQQVLDKTSKDLALKMEENRSLITIRQEQDVIIAQQRDELQRAALQRSAMRHSLNALQQRCGSVRRQMQNLESSLGAIQRQMYVGMAGAGLVLLAVVWVTRPLCKGRWPSLPVTASVTTEEVIAAPVPVIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SAU3</accession>
    <name>A0A088SAU3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclophilin 8, putative</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CYP8</name>
        <name evidence="2" type="ORF">LPMP_241280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699468.1">
        <property type="nucleotide sequence ID" value="XM_010701166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SAU3"/>
    <dbReference type="GeneID" id="22575537"/>
    <dbReference type="KEGG" id="lpan:LPMP_241280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240022000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_241280"/>
    <dbReference type="eggNOG" id="ENOG502S47E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="407558at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="1">
        <location>
            <begin position="80"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="242" mass="26456" checksum="E244CDE4768FBB91" modified="2014-11-26" version="1">MTALKSPQPISKSLVFPIFVNTHPYSAFSELEKRQLGVCPAPQLTMPPRKAAAKVKPHISDSTDVDLQNCLLRIDKGTDVYGMLVIELESGRSPKACELIAQNIPGSNATDKSRGKQGVYRNCRFLRLTKEGIQTGEVIPAAKSVPAAELEGELGRVPHCYGAVSLCRSSASFDGSQFFICLTRDSAELDHLNKKYVCFGRVVEGQDILAALQSDLAEYSGDMGLLSEDCPYMMMELTYALM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SBG1</accession>
    <name>A0A088SBG1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA splicing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_251430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699713.1">
        <property type="nucleotide sequence ID" value="XM_010701411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SBG1"/>
    <dbReference type="GeneID" id="22575791"/>
    <dbReference type="KEGG" id="lpan:LPMP_251430"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250020000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_251430"/>
    <dbReference type="eggNOG" id="KOG0007">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="447637at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045146">
        <property type="entry name" value="SF3A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316">
        <property type="entry name" value="SPLICEOSOME ASSOCIATED PROTEIN 114/SWAP SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316:SF12">
        <property type="entry name" value="SURP MOTIF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00648">
        <property type="entry name" value="SWAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
        <property type="entry name" value="SURP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SURP motif" evidence="2">
        <location>
            <begin position="165"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="394" mass="43156" checksum="E985B3503B7CB562" modified="2014-11-26" version="1">MENEEALPTIVVPGPELREKVDAFAARLSALDRRKADEMVAKLLASSKRNQFLFVDTSHIFFPYFLSKLTEFRQHPELRPQKPSEHKVSVGAAGGEKGAATTTKTGTITRTMGGTAGAKSDPKREELLRQTEAEARRYLEDPFPNHYSLDRKAGTVDVTALLMDVLSTMAQYTAKYGDKFLAAVKGKQRHNPIFHFLHEDDVRHGMFCKLVESYRRILTFDEEETETRLENLQSQSYLLGTVCEEKMKYAKAALARRRAALLTDEELRGRLQWTLFSVVKTFRLSDLQLDGPVPETAASKQRAAPAANATFISPALTSTATSRPRAGEVTGPVTPAAAASGGSTTAHATTLQPPGAASSSFAPVYMSSSLVKGTGSNGKRPRERGGHREAQGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SBM4</accession>
    <name>A0A088SBM4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Helicase-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_252130</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699783.1">
        <property type="nucleotide sequence ID" value="XM_010701481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SBM4"/>
    <dbReference type="GeneID" id="22575861"/>
    <dbReference type="KEGG" id="lpan:LPMP_252130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250023400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250023500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_252130"/>
    <dbReference type="eggNOG" id="KOG0385">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17919">
        <property type="entry name" value="DEXHc_Snf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="207"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="505"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="655"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="689"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="896"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="697"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="716"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="903"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="927"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="958"/>
            <end position="971"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN99076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="971" mass="106503" checksum="3B11ECA41D3D7AF2" modified="2014-11-26" version="1">MAATASSESTHRGVAPLKRPRETAVAAPPSSAPPEPALDAPAAKRLLTRRAASEDDDDELTLLLGSQKARQVREADATMQDVARAQQTPSPPLSPSWPGHRGGATVEASSGACAVRSLPWQTPSSATRETIARHFQRQFEWELHHSTELFDAFEPFFKDRALNRIAADDELRPVLHAALPVITSETVGALPGCTLRSYQMEGVQFLLSHFHRGMSAILGDDMGLGKTAQVSAFLHSLKLLHNIDGPHLIVAPLSTLTNWTRELARWAPQLRVVKYHGERRTRAATSAGRHNRHAVFVTTPALLHLDKRVFRKRAWVTVVVDEAHVLKAHDTAITSASRKLTACYRVAVTGTPVHNNVQEVWSLMSFLYPWLMAAYDPGVRDPVRQAEECAKVLQYIMLRRTKADMELGIPPRVDEPLTKLVPTYVQLQLLSLLTAHALQESSSGHQLHGHLSHQRAVCNHPLALRLLADKGRTNGSQEPIEKRMRAAGVPMDAAHLIDPSAKMRYLDTLLPQLKAQGHRCLIFSNFTTTLDLLEAVCQLRGHSYERLDGSCNRVERELAMLRYNHPASSCFLFLVTTTAGGVGVTLTGADTVILFDAHFNPQLDRQAADRAHRIGQTRVVRVYRLCLQGTIEEHIRDIAARKAYLGDFIVEGGQRHGARGRGRFTTNDGADTPRITADDIREVLHRFEEKHRAKQQADGSPISSSTLLRPSDEADGSSSSGSGSLSAEDAMVKDLLHVEANRLRGSAAAAVMRGGGGALASPPKQTHRCFCCGDVMHPMEPLLHCTVCPKAYHAACIGKRPPRSGETVKRLWSCPRHECFSCGKQQAADGAIFMCDTCPRSFCFDCLDPRYLEMDASGARLLHIRDTYAGMEEEEVKPKRSCYYVTCLRCCGLLSSSSSSAADDTDETDDDNDDAGGYNTAAVVDSDGLEIADDDSDVSVEDGGNCRNSLGPLSLMEGESRCGRQPEEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SBN5</accession>
    <name>A0A088SBN5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRO1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_252230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BROX family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699793.1">
        <property type="nucleotide sequence ID" value="XM_010701491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SBN5"/>
    <dbReference type="GeneID" id="22575871"/>
    <dbReference type="KEGG" id="lpan:LPMP_252230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250024500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_252230"/>
    <dbReference type="eggNOG" id="ENOG502RZK5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2141925at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038898">
        <property type="entry name" value="BROX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23032">
        <property type="entry name" value="BRO1 DOMAIN-CONTAINING PROTEIN BROX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23032:SF13">
        <property type="entry name" value="BRO1 DOMAIN-CONTAINING PROTEIN BROX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="2">
        <location>
            <begin position="12"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="389" mass="43661" checksum="3BC341E6107A2362" modified="2014-11-26" version="1">MFNNDALKYVLPIIPVRQTEKPGVNSQVEVDLSSSDKKAVGKERDACIKLFDDFYKHLVRKENSVDDKLSTSAGCEKYVKDLVDSIDEYTSFLANIVSKTPKFASLQYFYWSSPLTDKQEMAFDDYRYELLGVYYNVGAILMNIAQYLLCVRVTVGTLSFLEKDAYRALIKASAYFHFCANIADNMKEHEIGVAQVSIPLDVEKEMAIFLESLALAQAQEIGVSKAFSADPKENTETTARLSHQLFLMYEAVCTNARTINTRSKAFVDISTLSILKRDIFHALAYQHAASHLFNKNPGSGLSLLNQGLERATIVEDYLTKSQKGKLKLPFNAERFVGLCTKNITNNTERLNKINSLVHRAQPDSTKAPLPPPQPLAIRPDISLSFRLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SDG0</accession>
    <name>A0A088SDG0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Haloacid dehalogenase-like hydrolase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_281480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700488.1">
        <property type="nucleotide sequence ID" value="XM_010702186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SDG0"/>
    <dbReference type="GeneID" id="22576593"/>
    <dbReference type="KEGG" id="lpan:LPMP_281480"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280020800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_281480"/>
    <dbReference type="eggNOG" id="ENOG502R1X4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27226at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47267">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47267:SF4">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE PHOSPHATASE YIGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01228">
        <property type="entry name" value="COF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01229">
        <property type="entry name" value="COF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN99781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="378" mass="41714" checksum="812E377B63D14D72" modified="2014-11-26" version="1">MCQSAPFRIVASDMDGTVLNSDHEITEYTMETLFQLFLHYDVQFIFATGRHYLSVHKAREELSTYFAKRSSEYRRSVKSHPCGEGDNPGTGKYVVADSTQPGFFLVTSNGARIHDTKGKLIVSHDLDPDIVNALYQHYGLPYTSRHGPKAVKPSVGYSPHVSGSMEAAANGLMKGGDKNPEDIVSTSAYTTDEWFLTALFMPLPDIEKKFGVRPFLVPFDSEDPESANASVFNSFPLEGVGKVCFRCSDPSILDEMERSIRQQFGDRVSVALSSTRCLDVMPGNISKASALQEIVKLLSSESAQGHHNTRPPMLKDIIAFGDSMNDEAMLKTVGKGCIMKNAHERLKKTLSNCEVIGSNEENGVAVKLREIFQISLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SDK9</accession>
    <name>A0A088SDK9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Double-stranded DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_282030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PDCD5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700543.1">
        <property type="nucleotide sequence ID" value="XM_010702241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SDK9"/>
    <dbReference type="GeneID" id="22576648"/>
    <dbReference type="KEGG" id="lpan:LPMP_282030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280026900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_282030"/>
    <dbReference type="eggNOG" id="ENOG502S2G5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10252486at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.140">
        <property type="entry name" value="PDCD5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002836">
        <property type="entry name" value="PDCD5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036883">
        <property type="entry name" value="PDCD5-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10840">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10840:SF0">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01984">
        <property type="entry name" value="dsDNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015730">
        <property type="entry name" value="TFAR19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46950">
        <property type="entry name" value="Double-stranded DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="11"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN99836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="13107" checksum="485202A861203D10" modified="2014-11-26" version="1">MSRVPISEEQAQEMMAKQQVQQERMEAFEEQKENMLRAFVSAEGRERLKRIAQVKADRAQAVEMHIIQAVQRGKMQPPVPDSTVRELLGQMANQEAESKSHITIARKRMDDDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SDX1</accession>
    <name>A0A088SDX1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tryptophan--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LPMP_290060</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Trp) + L-tryptophan + ATP = L-tryptophyl-tRNA(Trp) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIN99956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700899.1">
        <property type="nucleotide sequence ID" value="XM_010702597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SDX1"/>
    <dbReference type="GeneID" id="22576770"/>
    <dbReference type="KEGG" id="lpan:LPMP_290060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290005600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_290060"/>
    <dbReference type="eggNOG" id="KOG2145">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261385at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000007">
        <property type="entry name" value="Tryptophan--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000033">
        <property type="entry name" value="tryptophan--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055">
        <property type="entry name" value="TRYPTOPHANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIN99956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="473" mass="53441" checksum="609AAC4EFB59C939" modified="2014-11-26" version="1">MVELPLPLFRLHSPGFYLLGAFTALYPADETMYCMASLLLISFGSAHELSFGCTSQLDSKLGSTPLFAAHCFFADFLSMEGPAVQEAIVTPWTVEGDVDYDKLIKHFGCQAIDERVLDRIERLTGTKPHHFLRRGIFFSHRDLNLILDAYEKGEPFYLYTGRGPSSESMHIGHLIPFMFTKWLQDTFQVPLVIQLTDDEKFFFKDVTLEEIDKMTTENLKDIIAFGFDPNLTFIFRDFEYVGKMYRIVARIEKAYTASQVRGCFGFKMEDNCGRWMFPAIQAAPSFSAAFPHIFPLGKGNVFCMIPQAIDQDPYFRLTRDVAPRMGFLKPAVIHSKFFPGLSGSKGKMSSSTGAAVFLTDTPKMIKDKISKHAFSGGGADKKEQLLLGANTNVDISVQWLRFFLEDDEELKRLQKDYMLGRIMTGDVKKVLIRTLTNIVTTHQESRKRVTDADAELFTAVRLMGPAKEAAESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SE08</accession>
    <name>A0A088SE08_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_290410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIN99991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700934.1">
        <property type="nucleotide sequence ID" value="XM_010702632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SE08"/>
    <dbReference type="GeneID" id="22576805"/>
    <dbReference type="KEGG" id="lpan:LPMP_290410"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290009300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_290410"/>
    <dbReference type="eggNOG" id="ENOG502S48V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="251319at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN99991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="412" mass="42704" checksum="93F3CD35D26D382E" modified="2014-11-26" version="1">MGRNKPRSKAVDVTKSLLQPTSITDHIAVQVAANKVIQVAEDDLSPTQGSEAAFALRREGKLDASMKLCLNWRQGNCHNHAACSFAHVIPYFGVAGDEGDTPRTPGKPGGFNVDPGGGASPSSTAAVGEGSGRGGNAAPNAPWPQRFAPSSYSAITTLGQHVEEEKTVPVAVPVSVAVSAQLCANSAADVKPEVAESADTTEVAPVAPFSSTSPSPPAVVSADRLRSILVSLTATLASKAGMGSITDPAEPADADNTDDITQPHSAWLREMAERAEEEEERATLSDGTYSWQQPLKASMAEFVGVAGKSLLGEPLWQDGSAVDLYRSLAGRAAAATTIAMRRGWEAGESRGQEETVGYAAIADPHVFSTAPMPTEVSGVDPWASHLTLVDLLLEGAECSGAENGSISLPPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SFN1</accession>
    <name>A0A088SFN1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">N6-L-threonylcarbamoyladenine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_310100</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701402.1">
        <property type="nucleotide sequence ID" value="XM_010703100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SFN1"/>
    <dbReference type="GeneID" id="22577436"/>
    <dbReference type="KEGG" id="lpan:LPMP_310100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310005900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_310100"/>
    <dbReference type="eggNOG" id="KOG2708">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="239417at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd24132">
        <property type="entry name" value="ASKHA_NBD_OSGEP_like_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000141">
        <property type="entry name" value="Probable tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000295">
        <property type="entry name" value="Probable tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01446">
        <property type="entry name" value="Kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034680">
        <property type="entry name" value="Kae1_archaea_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF14">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="11">
        <location>
            <begin position="27"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="133"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIO00602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="364" mass="39802" checksum="173A6DE382F505CA" modified="2014-11-26" version="1">MKRTLSLGIEGSANKIGVGVVDQTGAVLSNVRETYITPPGTGFLPRETAIHHSQCVLQVVQRSMHDAAVTPADIDIISYTKGPGMGAPLSVGCTVAKALSLLWGKPLVGVNHCIGHIEMGRVVTQSENPVVLYVSGGNTQVIAYADHRYRIFGETIDIAVGNCLDRVARLLGISNDPAPGYNIEQKAKRGKHYIRLPYTVKGMDMSFSGILSYVEQLVRHPQFTEPDVYDLSDKRRKAAPPLTSAPVPPGETFNTDDICFALQETIFAMLVEVTERAMSQVRASDVLIVGGVGCNKRLQSMMQTMAAERGGRCFDMDQRFCVDNGCMIAYAGLLQYLSGFFTPMAEATITQRFRTDEVYVAWRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SI49</accession>
    <name>A0A088SI49_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Presenilin enhancer 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_332110</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PEN-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702302.1">
        <property type="nucleotide sequence ID" value="XM_010704000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SI49"/>
    <dbReference type="GeneID" id="22578364"/>
    <dbReference type="KEGG" id="lpan:LPMP_332110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330028200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_332110"/>
    <dbReference type="eggNOG" id="ENOG502SP90">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="524898at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070765">
        <property type="term" value="C:gamma-secretase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019379">
        <property type="entry name" value="Gamma_Secretase_Asp_P_PEN2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16318">
        <property type="entry name" value="GAMMA-SECRETASE SUBUNIT PEN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16318:SF0">
        <property type="entry name" value="GAMMA-SECRETASE SUBUNIT PEN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10251">
        <property type="entry name" value="PEN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO01502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="14153" checksum="CDE5B9C1470B0842" modified="2014-11-26" version="1">MLVRGPLTLEKAESACQWYYRIGFFGLPWLWGLLWLFFRHYKDESETIRWYVKRARRYSIAGCVVFVVMSIVLLFAIPPTSALWVIAPFQDTFQWGYFAVNTSEAADAANTSTRSYDSASFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SI54</accession>
    <name>A0A088SI54_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein HGH1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_332160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702307.1">
        <property type="nucleotide sequence ID" value="XM_010704005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SI54"/>
    <dbReference type="GeneID" id="22578369"/>
    <dbReference type="KEGG" id="lpan:LPMP_332160"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330028900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_332160"/>
    <dbReference type="eggNOG" id="ENOG502QT8B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271945at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:002070">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039717">
        <property type="entry name" value="Hgh1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387:SF9">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO01507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="422" mass="45995" checksum="CA2C5646CBD7EB22" modified="2014-11-26" version="1">MASVSLSVSPVTGEQTMPSADTIQQFQETFSFVRHEREDVRKMAIHGIAEHSKENRDLYLFLASAQYGPSCTDALLQCLHPGGKLVLGDILTILINCSADGSCAEMLVQRKVVRKAMRLLDGMARSDQPESYVRSIQELTLMLLNNLTASHVTAIDDLLQKNDEDMRGFYLGKLQVYYERFVSAMEAARSVVNGEAAEVGEDAAKKIDHAVSDDGGDLANPKHTSLPATSHRDLSRWILHILLNVTRTLDGQELLLEDSEWRGTLSSSLSSPNPRHRYLAAQCYCNCSCSPKPLYSLILKSDALVTAVERLNCKEPIEDIQKSLAEFIASMLESEDGMARLESVNAKKVLAGALDVSKAAHATKVAASASCVEVVEEDGSSVAATPAVTLAPSVSEFLERSVLPYLDDIMDAYIAPGSDELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SIR3</accession>
    <name>A0A088SIR3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">rRNA adenine N(6)-methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_340700</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702497.1">
        <property type="nucleotide sequence ID" value="XM_010704195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SIR3"/>
    <dbReference type="GeneID" id="22578574"/>
    <dbReference type="KEGG" id="lpan:LPMP_340700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340012400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_340700"/>
    <dbReference type="eggNOG" id="KOG0821">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="16079at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF26">
        <property type="entry name" value="RRNA ADENINE N(6)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA adenine methylase transferase N-terminal" evidence="8">
        <location>
            <begin position="61"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="153"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="439"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIO01697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="470" mass="51304" checksum="9A41478531CFB5D3" modified="2014-11-26" version="1">MRGASASSSSSLQAAAPVALPPLRCPGGPRVTAEGIKQLYKVPHAGFLAKYDQRFMLNLKLTHQLVSYLSRTTLTTPDKVLVELGPGVGTLTRSLLTRPCVGVLGVEVDERFNPHLEQIRNYTNQKFQWVTADVLKVDELELLRSAFPHFVKANMRRPPSPGHETSEANAAAGADADSGSQRAGFTGDAGEHDTEGYEGAPLRSAQRERLLRQRRARKPHLHSGATSRRGAGGAADTAGTATPPNPAFDVTNHWWSNGNAKVEVIANLPFAIITELLMRYAVDCAQHRGLFAFGRVPVHIFAQREVAERILAPAGSVEFSRLSVLCQCFFHVRLKQTFVDQTYYPRTEVEGAMLTLEPRSVPLAHDLDASTLIHFTNLLMKPGLRAATVHKSLSRFAPAELVQYMLQELRMDGAMTVLDLSVVEVTRLASLWQQFVTMSQQQPQQGDDGTEADAGTAAPDIPMAPCSSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SIV3</accession>
    <name>A0A088SIV3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_341160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702542.1">
        <property type="nucleotide sequence ID" value="XM_010704240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SIV3"/>
    <dbReference type="GeneID" id="22578621"/>
    <dbReference type="KEGG" id="lpan:LPMP_341160"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340017500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_341160"/>
    <dbReference type="eggNOG" id="ENOG502SA19">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="246298at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="248" mass="27285" checksum="CE5E6560BC6A636B" modified="2014-11-26" version="1">MTEFPPAGAGATTIFIRCATLHSRGELLNGFFFAHRAALGIQDWYVSAPTTVNSGTGNEEAQHSSTMDSAAAGDLPHVASSPRLPPHFPVEVLYVRNSRKPYFLLEWRYPTSEEEEKRKEPSDSGGDEKEEVAKAHEAQAGSSQGRVAEELVRQLAERTLALGKHELCDNGVTWKGQPVLICVASSGMTVMAERRKLELRDSQRKVQRAAEKRERADADTAAQTARAKQQDAGAVTAAFIPRCVRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SJ96</accession>
    <name>A0A088SJ96_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_342710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702697.1">
        <property type="nucleotide sequence ID" value="XM_010704395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SJ96"/>
    <dbReference type="GeneID" id="22578776"/>
    <dbReference type="KEGG" id="lpan:LPMP_342710"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340033200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_342710"/>
    <dbReference type="eggNOG" id="ENOG502S576">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277743at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="153" mass="18060" checksum="A2E874F950C07215" modified="2014-11-26" version="1">MTKLVRKLKQMAKKRAHRKTVQKRKVERAQRELERRSEQQSQKLEDEVDREMARLNGEIEEEVNARAAASSRDIDNDAARSVMVKRAMRIVGDLILDTPVKKSKKQMTRKQARRREKMVERGLAVSDSLSNKWDRKKRCVKIRAQIRNEDLHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SK68</accession>
    <name>A0A088SK68_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_350580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702997.1">
        <property type="nucleotide sequence ID" value="XM_010704695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SK68"/>
    <dbReference type="GeneID" id="22579087"/>
    <dbReference type="KEGG" id="lpan:LPMP_350580"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350010900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_350580"/>
    <dbReference type="eggNOG" id="ENOG502SFWR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277356at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="18"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="202"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="255" mass="29795" checksum="FDBDE76A991B2A7E" modified="2014-11-26" version="1">MSAATAKMAATGYDRDVAVKVAEENYSLQKRLARMEREEQQQRRAADYDSRFEGTADTIANDRMRRRNNALQDEIAELESQLRELQMINIIDLQHEYTRLDNRRAYLLNELAGLRRILANQRKDVKRATRTVNSQHELRRQNSVEHASSIEDIQMFREKRESLAKETQHLIAKERHLKSKLETLPAPGEDHEVVASHLREDNEKKDHTIARLEATLKEEQQKAGAQLAEANSSDDIQRLREEYVQLNDQLRRSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4F9</accession>
    <name>A0AC62A4F9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase M20/M25/M40, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3320440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="XUY36752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="472" mass="51182" checksum="D9528480A5A26E51" modified="2026-01-28" version="1">MGDCDWTVIQKAVGAEWDASIIPALSAYIEVPNQSPDFDPHWATNGLMEKAFHILIDWVKGQNLLGLSYEFMEVEGRTPFLLVEIAGTERTNNTVLMYGHMDKQPPLRPWAEGLDPHKAVMRDGKLYGRGAADDGYAIFSAITSVSVLQRHGIPHGRVVVVIEACEESGSFDLDYYMAQCKERIGNVDLMVCLDSGSLNYDQLWLTTSLRGVTGGVLNVQTLTEAMHSGVAGGVVPDTFRIARELLDRVEDSKTGTVLLPEAHCEIPDHVAKSMVSMKSVPFKQQFAMADGVSAEPGDNVELALRNFWKPSLTVTGANLPEPQIAGNVIRTLTSLKLSLRLPPLVDSGKATQAMAKLLTTNPPYGAKVWFEPEVPGDGCATPELKPWLSNALNEGSKMAYGNPLAYQGMGGAIPFISTLTKMYPQAQFIVTGVLGPKSNAHGPNEFLHVGYAKGLTLAISHVVAAHFLLAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4J9</accession>
    <name>A0AC62A4J9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Heat shock protein 83</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">HSP83</name>
        <name evidence="1" type="ORF">LPMP_3320090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="XUY36717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="704" mass="80794" checksum="63C432B9856AE93D" modified="2026-01-28" version="1">MTETFAFQAEINQLMSLIINTFYSNKEIFLRELISNASDACDKIRYQSLTDPSVLGEETHLRVRVVPDKANKTLTVEDNGIGMTKADLVNNLGTIARSGTKAFMEALEAGGDMSMIGQFGVGFYSAYLVADRVTVVSKNNSDEAYVWESSAGGTFTITSVQESDMKRGTRITLHLKEDQQEYLEERRVKDLIKKHSEFIGYDIELMVEKTAEKEVTDEDEEEDESKKKSCGDEGEPKVEEVTEGGEDKKKKTKKVKEVTKTYEVQNKHKPLWTRDPKDVTKEEYAAFYKAISNDWEDPAATKHFSVEGQLEFRAIMFVPKRAPFDMFEPNKKRNNIKLYVRRVFIMDNCEDLCPDWLGFVKGVVDSEDLPLNISRENLQQNKILKVIRKNIVKKCLELFEEMAENKEDYKQFYEQFGKNIKLGIHEDTANRKKLMELLRFYSTESGEEMTTLKDYVTRMKPEQKSIYYITGDSKKKLESSPFIEKARRCGLEVLFMTEPIDEYVMQQVKDFEDKKFACLTKEGVHFEESEEEKKQREEKKAACEKLCKTMKEVLGDKVEKVTVSERLSTSPCILVTSEFGWSAHMEQIMRNQALRDSSMAQYMMSKKTMEVNPDHPIIKELRRRVEADENDKAVKDLVFLLFDTSLLTSGFQLDDPTGYAERINRMIKLGLSLDEEEEEVAEAAPSEAAPAEVTAGTSSMEQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4R5</accession>
    <name>A0AC62A4R5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3420310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="XUY36795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="250" mass="26722" checksum="D69BAC31F588BD54" modified="2026-01-28" version="1">MWGAFGTVVRIYEFTTPDALGELPVTHSRIACVVLDACLKNEGLYSKVGQGLNSMGHVLPREYTDVLNVLLGRAPPVAIAEIRKTICAETGREIEELLACFDEAPVASAPIAQGHQAWLPPPADGSSPEPQRVAVKVRKPCISTQSVWGLCMHSAIMMPLNVLFDLPTDWSRKAVCDALARVIGGKGARRPRPISSNARGCRRHDGRAPDHTTGPATPQGEEPPRRATVCRGGGRRGVAACAHVSGLVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4S7</accession>
    <name>A0AC62A4S7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Structural maintenance of chromosome (SMC) family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3420460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="XUY36810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1322" mass="147050" checksum="6732179ED45D3FDF" modified="2026-01-28" version="1">MLSKIHRVELENFKSYYGKGVIGPFKDFTCIVGPNGAGKSNLMDALSFVLSSSVTPARASSMRGKALVDFIHRKAKAASKGCSVTLVVRHPESQRPVASAAAPADGESGMNDAVAVAARCGAVVADDGEHVHHSSTVETSFTRQVDPQGAVSCLLNGKPATEKEYVAALTQNRIGARVDTFLVFQHQVEAVAQKKGKQLTELLEQVSGSGELQGEYAAKKAALEKANEALMSASLEKRGAAVAVHQMRLAKKEAERYEELRQHLASVRQELALTELFAVETELEKHKAELQQRRDALAALEKGIATEQAIREMKRAYATRHKVYLEQLKKTRKSADDLRLKHNTVERIKAALAHLTRKAELQRQELEAAQKATTVRSAEAERLEGQLKKQKALLDTFEKRCTADDTRRVTLDAVLNQQQLDEYRQLRKEAECATVVLRQRRETVLRQRDSAQEALKQCDRATEAHQQQMRDASQAIEAAAKYGAELQRRRSELEETVSTLKTQLTEASTDLAKMQRKNRAREAELARLQEQLHDLRYMKDTSKQNSRMADALQALCSLFPIRGRMVDLCAVPNDRHRNAVTVAMGKNLEGVVVETTAVAIRCVKYLKEQRMPPMTFLPLDAVQGKAVDDRLRTFGGTCKPIVDVVRFEPELEPVVRYALGQTLLCDTVAEARLVAYGRDGERFKVVTLDGTVLLKNGSVQGGLVSVQNRARKWDEKKYEDLRVARDRLLSETAVGGEAELARTQISIRDMEARRAFAEKRVAVVHTEQIANDAKTQRLTEELEKLESRGADFTTRHSSYATELQVIHRELLELSKSISRVEGQVFADFQKRVGIPNLLSLEGQQAQEAKQRAETRQQLLLVIHKLESSLEMEVKLVGDSKIADFEEACARLNNEREQCKKDLTDYKALVEKAERQHQEMRRTAVQSRTELDALEQQIRNETRNSETDLARVAQARKIVTGIQITCDSLRLRRLNLVRRCQMDEIGIPLKPAPSSGAKHAQGEDTDTATRALSGLSAPPSRQRSSAAGSHTHVLLSEPFTLLVEGGASQSGVRRGTSTASPPALFPTLDSETAMCINFSSLTEAQRVVAEDRAQFSAYSHRTQVQLEALAAEMESLAPNMKAASRAVASEDRLGTSSTLLEEARDAARVASREFTRVKEQRTARFMEIYEKVAATVDRVYREITMGTRAHAVHGSAYLSLENVEEPYLGGTTYHATPPLKRFMPMALLSGGERTMAALALLFAIHEVSPTPFFVLDEVDAALDAGNVEKLASYLRKNSQLCQLVVVSLKEQLYHMADMLLGVMKDKERESSKVLTMDLRGYPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A537</accession>
    <name>A0AC62A537_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Memo-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3520150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="XUY36847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="328" mass="36621" checksum="AF50566B0C3AB94B" modified="2026-01-28" version="1">MHFVRSATHAAPHGCGWYEAIPERLKATIDDYLREVTHHYEDESRGGARMMGLIVPHAGMSYSGRTACEAFAVFREYLYAKGSKGSKVERIFILGPSHTKGFEGCELSAASAYETPFGPLKVDTATVDRVITALCKAGVGAATASRRTDEAEHSIEMETPYLSHILHYPPAATGTSTQPAAARVSIVPIIVGWTNRQDEKAICDVLKPYMDDARNFFIFSSDFCHWGDRFSYTYHYQRYQYPNIGDSIIAMDHAAMELLERRDLEGWYGYLRTTKNTICGRAPISIGMQHWMDEASKVQIKFVHYSQSNKCLSVEDSSVSYAAAIILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A545</accession>
    <name>A0AC62A545_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucose transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3520290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="XUY36862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="560" mass="60469" checksum="49C056364DF7F8D7" modified="2026-01-28" version="1">MSSKLQANDHPSDSISEKEPARDDLKKSIDDQSDAPPFLSASNAKVILVQAIGASLNGYSIGFVGVYATLFGYSTNCASFNSEQGCVTVPNADCKWFTNTNSTPFCGWTDITCRRTYTYTNLSGMPAAITQCEADPRCRWSYSSQECQNPVGFSSAESGIFAGSMIAGCLIGSMFAGPLASTIGARLSFLLVGLVGVVSSVLYHVSCAENEFWVLIVGRFVIGLFLGVIGVACPVYTDQNAHPKWKRTIGVMFQVFTTLGIFVAAAMGLALGQSISFDQNKDQMVMARMQGLCAFSTLFSLLTILLGIVMSESRAQFGGGEEGAIELDPNEYGYLEMIPRLLMGCVMAGTLQLTGINAVMNYAPTIMGSLGLAPLVGNFVVMLWNFVTTLASIPLSYVFTMRQLFLFGSIFTSCMCLFMCGIPVYPGVSKKLEVKNGVAITGILLFILGFEVCVGPCYYVLTQDMFPASFRPRGASVTQVVQFIFNLVINVCYPIATEGISGGPSGNQDKGQAVAFIFFGCLGIICFVIQVFFLHPWDDERDGKKKGSQLQEKEEIVDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5T9</accession>
    <name>A0AC62A5T9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha tubulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1320100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="XUY36981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="451" mass="49683" checksum="3D47FCCC1FBC5BF5" modified="2026-01-28" version="1">MREAICIHIGQAGCQVGNACWELFCLEHGIQPDGSMPSDKCIGVEDDAFNTFFSETGAGKHVPRSLFLDLEPTVVDEVRTGTYRQLFNPEQLVSGKEDAANNYARGHYTIGKEIVDLALDRIRKLADNCTGLQGFMVFHAVGGGTGSGLGALLLERLSVDYGKKSKLGYTVYPSPQVSTAVVEPYNCVLSTHSLLEHTDVATMLDNEAIYDLTRRSLDIERPSYTNVNRLIGQVVSSLTASLRFDGALNVDLTEFQTNLVPYPRIHFVLTSYAPVVSAEKAYHEQLSVADITNSVFEPAGMLTKCDPRHGKYMSCCLMYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKCGINYQPPTVVPGGDLAKVQRAVCMIANSTAIAEVFARIDHKFDLMYSKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGAESADDAGEEDVEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A613</accession>
    <name>A0AC62A613_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ubiquitin-conjugating enzyme, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2020800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="166" mass="18648" checksum="C69FB556B5389A7C" modified="2026-01-28" version="1">MSARTVRRAHMDFARLKELASRGSSTIRAVDMADEQGGTASGDAFHWRIRVMPPAESVYHGTTYDILFTLPQQDYPFKPPVVRVLTHIFNPMIAENGAVCEGLLQNDDWKPTTPVMDVVARVVKAIFLEYRTYAVLNEKAAGIMSTTTPEEFQKHVQRMRASDSCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A639</accession>
    <name>A0AC62A639_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tuzin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2020050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="509" mass="57472" checksum="BA3D9FA6CC51F213" modified="2026-01-28" version="1">MEGAPVSAVAEVSTRVHVQVGHTATNEGRVVGGIVWRVNSNGTLGVLMDKSCFAAQVSQDDLVLVEGHARITLERGYLDMVKWIRDAGVHRRADRERLSSVLYQRGWRVDRLYLLGPSDVHCVSYVKRSVRLLVLERAEWQRDHHAELRALQRERVRERAWRCVIQRYSGFVSANWAALGVLSVLLWNFKGCRRHQRTFQVKRAVSTLTDTDQQYTSSPAEPPPFVERAAEESWARQVLRQPDITHPRIAVVTGLRGCGKSSLLRSAARKEHRPALFVEVRGGEDTLSCIVKAMKVPNLECCGDHLEFIADTFTKAAKVHGERPILVLTLREGCELSRVYNESALLASDRRLCHLAYEVALESLTTQNVLLPRLDFYLVLNFTARQALQCTEHAVDATSMVRFFEVMGTHRSDIDEPLAAVRHRGVFVVNYIDQRLLRAMRRAEAACASSGTLRAAVKRLAEAEYCVGQQNGPGVLRDAELKGIVLYDPVRDRWMFTHKVYHTAARCCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A667</accession>
    <name>A0AC62A667_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amastin-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0820240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="XUY37304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="199" mass="21939" checksum="E283881E7AD642DF" modified="2026-01-28" version="1">MVFTLALLLYAVLQLIAFLFVLVGTPIDMFRSRDEAPFGNTPCITLWGIKDKCYSGMLSQNSDDLWSPCPGRGSRFRVAQAFAIISIFVYGIAAALGFIMLWCCSSLRLVCLALNLTGVITLCVVWASMMRTYYALDGQCFGQRFRMNFGSGFVLLVLAWCLDIINMVFLLLPSQAKDPSEIGEPIKSAAASESNNAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6I7</accession>
    <name>A0AC62A6I7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0420070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="XUY37424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="522" mass="52666" checksum="E154D07D42C5BC53" modified="2026-01-28" version="1">MAPLAPRCCAPALLCAVLVLAAVLVRAESVTVTDDLTMSGASFSDYTMTLGLASSTADVVTVQLMNSQVSGKGLTVQSSGDGLASSARLSMSMLLTTVTQAAITFSGAMPANSDIRIVSTIGSLTSAQSLFDFSGLALDSNVTVTVENTAVTWPKDSINTGSIVLISAGSNAIGIRNLAALFVLDAVATNGASVVRVDAQSSFPVSKAAVLAIDYGRCEECTGALVSINAPLVVDGSSMFRVTNCKAVGASKGLLASAGSTTVSGKSVYLVSDSAVESVSLFSFLTGIEDSSEPYPFTVSGGSTVSFLNLEAPSTGITNQDTLSASADSKVIGGGCVIKGVALNTAEVYKSNGLAVTTVVDRQGASGGTCANAKCIPGNTGAGAAVSGTDPCTCQCSSMDYNPPSCSTIVDPTQNYNPTDVCVVPNCITCDRLSPSTRCTQCATGYILTSDQRCILPTTRPPVCNVPYCTQCVTGSGSRCSTCHYGYTSINGACIANANAAAGAHTVALAAVVCVAAALYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6L8</accession>
    <name>A0AC62A6L8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amastin-like surface protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2021000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="194" mass="22191" checksum="6A5C0B5FCE518DDD" modified="2026-01-28" version="1">MEFNPFIIVYAAIQFIAFLLVVVGTALDMFRLQSRENFEDRPCITLWGLKPYCNSIVYSLSSDERFSLCPVRRKRFHMAQILAVVSVGVYGTAFALGVIMLYCCLHLRWVCLLLNIVGFVILPIPLALMVLSYKTDENSLCPKLRDDYDFGVGFYIFATAVGMDFIDIVFLLIPWQYDYLDVTCNSKEGNSQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6S0</accession>
    <name>A0AC62A6S0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Leishmanolysin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">GP63-28</name>
        <name evidence="1" type="ORF">LPMP_1020330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="XUY37375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="557" mass="60464" checksum="89439EADDB35BD45" modified="2026-01-28" version="1">MAVGAAAVWAQAAGHHCIHDRLQARVLQSVAQQRRPPGSVSALGLPYVSTDPISSAHTVDWALADSTSPSVAHSADWGTLRILTSLEDLNDHDYYCSYVGQLVNNHQGAMDICDAEDILTEEKRNTLVNYLLPLALQLHVERLKVRQVQGTWKVTGMEGDVCGEFKVPEAHVTIGVSNADFVLYVASVPSGPGVMAWAVICQTFSDSRPAVGVINIPAAYIRSAYDQFMLRSVAHEVAHALGFDLTLFDELELGDEVSDLRGREYYVPVLNSPTVAAKAREQYGCPTLEYLELEDTGGASTAGSHLKGRNAKDELMAPVMGAGYYTNLTLAVFQDLGFYQADFTKSEVMPWANLASCDFLTKKCMEKNITQWPGMFCNSTESSYLCPTDRLKIGRCSITTQDDPLPTYLRYFIKPSVGGLSEFMDLCPIIVGYSNTACNQDPSTASPTVKKFSLFSDSSRCFDGVFTPKHSTGPPGPYNGLCANVKCDRAHHRYSVRVYGSSGYVACTPGERVELATTSAAFVEGSYIVCASYVEVCQANIKGVIDFEGDAADTAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHW4</accession>
    <name>A0A088RHW4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Serine/threonine protein kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_040390</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="AIN95365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703687.1">
        <property type="nucleotide sequence ID" value="XM_010705385.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22571998"/>
    <dbReference type="KEGG" id="lpan:LPMP_040390"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040010300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_040390"/>
    <dbReference type="eggNOG" id="KOG0198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF32">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="867"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="174"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="331"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="421"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="686"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="906"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1016"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1198"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="424"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="686"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="910"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1019"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1031"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1202"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="897"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN95365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1332" mass="140277" checksum="658BFA47BD4F3100" modified="2014-11-26" version="1">MAVHISVATMLPTTRENGRHRHHPHPQRCQQRPTTTSSSIAGCEPPAFAVTTTVSGEGSCVHSGSSAQPRPRHRRSRSIHITLRKTRSGSRPVSAQRGSLTSMSRDLGAASSATGGARGRTPNTHQYHGSIESPSGASGDAASPASAATAAGTPPGSACGAALVPFTSPAGGGFVSPKLTPRHHGAASTSPRVPAGGAHQAPLFDGVANSNNNINSCGSSRMMNSLSYTPYILHTHGRSGDGTVSDGTTAAAAGATNVGSSSSSMVGGAGGSSSSVGPSSGSCVPTVHGFGYFNTFMNANHPYDMKQALLPPNMRDRALGLDAAHSDQAAAATAAHRRPFSSGAMSRRKGMSSGNHGRVYCHPSVFSPQAVSQVSHANGYRGRLRSNSMSSYNTPVDVYNGSSHCRSPTAMQRLNDFVFPYPESASGAPQQQPHQPQPGHPPSSAWCGHLSNMPTVNLETSPRLWLSAAHTAVQGQQEQRCRHHRARSYTVGGHVRSNSGCGRGDIVAAHITAEATTNGTSVSVGYAGNTAPCTPDRPISLASSIPAAAVPVAGAMATTAGGLCSRTSTLIHHSSVSTAASSVATTIPTVMTTLPAAPSLPAHTTNRISSAVTHAMTPQARQPVKAAVEAAAAEGTSAPRSTRVIAGLNPSAFFGSQRSVSSDIVNGLDDSVDSVRCGSLPSPNTSATNVVGSASGTPDRCNHGTSTAPGRYGGTAAFASSHRYARDSMASENKADDEDRRHSALLCRCSTTLTNTTTDENEQQHATQLLVIEMLRRNGMRRKSSTGGGVGNVNVAAVLSRARSARTNATSAAAAAATDIGGSPTTAIERWRAQEQQKKREGVQQHRLSAQQWREAFRRLQEKRVRWHMRGYIGRGTSGVVYEGILEDCERTPVAVKVLEVGVPMPVDLDTSSNGDDSKSSRQTSYTAIRGTAKSTSAAASEDETYMSPSQQEALLVLLREVEMMEKLHHENIVTCLRCQVTPVQNRYLELRQQQQQQRRGGSSSDDNWLSAVAVAGRGGERVGEPRHDSGGTSSGENQSPLLNAAARIPVQVEIVMELCNRGTLSSVVRQTPGGQLPVQVARRYLRHVLKGLAYLHHSNFIHRDVKGDNVLISAADVAKLADFGCSRRIMLTNNVYGAADSEGVTSSIATTRTVATDSRFTTIAEYQWFDTTGVAKTMVGTPMFMAPEIILASGTPSMKMSTASSPTSSVSGGNNGGPGSDNKATSPPAPVGYTASADIWSFGCLVLEVFGRTPWPTSGSNAYHLMKQIEQSVADLPPGVPHDTPAELLSLLRCCFHRDPHRRSTARALLRAPWMMCKDKELEEMPPRRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RID7</accession>
    <name>A0A088RID7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial ribosomal protein-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_060040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703887.1">
        <property type="nucleotide sequence ID" value="XM_010705585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RID7"/>
    <dbReference type="GeneID" id="22572210"/>
    <dbReference type="KEGG" id="lpan:LPMP_060040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060005400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_060040"/>
    <dbReference type="eggNOG" id="KOG4548">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="194611at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000088">
        <property type="entry name" value="Mitochondrial ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040008">
        <property type="entry name" value="Ribosomal_mL46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021757">
        <property type="entry name" value="Ribosomal_mL46_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L46, MITOCHONDRIAL PRECURSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11788">
        <property type="entry name" value="MRP-L46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Large ribosomal subunit protein mL46 N-terminal" evidence="1">
        <location>
            <begin position="47"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="291" mass="33549" checksum="79274D8073B87A93" modified="2014-11-26" version="1">MRYFRPDRPLVAATTSFVLSSCRTFHSQHRTPLIPQAHVNDRPTAQRIHVGYYIHRHQVVKHSLHPLEVEMGYLLEREQQRYSRHESAESATTFFASRGQTMDVLGRTDPNQIKGNFFGLEHYQDAMKMVMQRYTPEKRVTAADMWKPNGLGDAPPPRHTLHRKLDDFLYLIVQEEAAGKWTIPHTARKDGESLRMTADRAISTQNLEGLDCYVWSNAPQATVFLKDDNTRLFIYSAVYLAGRPQFASYEPKLKDHAWVTRHELLQYSDSFKSAELLKALLDISADGTFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIJ8</accession>
    <name>A0A088RIJ8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Delta-5 fatty acid desaturase, putative</fullName>
            <ecNumber evidence="10">1.14.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_071170</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.-" evidence="10"/>
    <dbReference type="EMBL" id="CP009376">
        <property type="protein sequence ID" value="AIN95802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704124.1">
        <property type="nucleotide sequence ID" value="XM_010705822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIJ8"/>
    <dbReference type="GeneID" id="22572452"/>
    <dbReference type="KEGG" id="lpan:LPMP_071170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_070017000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_071170"/>
    <dbReference type="eggNOG" id="KOG4232">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="260091at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03506">
        <property type="entry name" value="Delta6-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353:SF88">
        <property type="entry name" value="DELTA(5) FATTY ACID DESATURASE FAT-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="FATTY ACID DESATURASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015921">
        <property type="entry name" value="FA_sphinglp_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="9">
        <location>
            <begin position="135"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN95802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="417" mass="48285" checksum="6AE47D29CF752DE9" modified="2014-11-26" version="1">MAPDSALPHQPNEVLIDGVLYDCLNFRHPGGSILKYYLGSGDATETYRQFHMKLPRADKYLKLLPHRPAPPQLNVNVEEQKRLAKLSRDFKELQDTCVEEGLFDPSWPHIFYRFSELILMHVVGFYILFRLSLLWPIALVILGVAEGRCGWWMHEAGHYSVTGIPWLDIKIQEVLYGLGDGMSASWWRSQHNKHHATPQKHHHDVDLETLPLVAFNAIIARRGRRSVNIRRWISLQRYLFAPVTCSLVALYWQLFLHVRHAMRTRRYTEGAAILCRWIAVGVICHKLQVSFWQGLGGVLFSQAFGAAYIFISFALNHTHLPMLPEDQHAHFVEYAAVYTMNVTPSWLVTWFMGYLNYQVEHHLFPSMPQFRFVQLAPRVRRLFEENGLTYDSRPYAKSLQTTFKNLGDVAEFIVAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJ76</accession>
    <name>A0A088RJ76_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial carrier protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_091270</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN96042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704364.1">
        <property type="nucleotide sequence ID" value="XM_010706062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJ76"/>
    <dbReference type="GeneID" id="22572697"/>
    <dbReference type="KEGG" id="lpan:LPMP_091270"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090018200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_091270"/>
    <dbReference type="eggNOG" id="KOG0754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="193856at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF10">
        <property type="entry name" value="SLC (SOLUTE CARRIER) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="36"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="157"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="264"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN96042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="348" mass="37024" checksum="3271F6832DE4C3E7" modified="2014-11-26" version="1">MTGGKSEMIVTAGPSLSTSILPQMDEREWALRHLMKASLVALIPGAAQGAATVLLGHPLDTAKVRMQAAGPHTSRSTIGTMWSMATAEGPRSLYRGAVPPLVMEGAKRSLQFALWDWMRAFARDAPKSRSDANGAASGGAGSAWDAARHVVHRGMVGIGGSTFVSGAVAGGVGTLIGCPMHVIKIQTQCQTSLSTQNAWTCMRSIYDQEGFLGFYRGFRYNVVKDVCFASMYLGLYAILRDHPFLEPPTLSPAAATATTDPSRRTKLGAFLSGAVASMATWALLFPLDTIKTLVQARQAHAVVAMLHQPALLYRGLTASLMKAGPVSGVAMAVYEQTWVLTNRRPASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJ99</accession>
    <name>A0A088RJ99_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_080720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="AIN95880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704202.1">
        <property type="nucleotide sequence ID" value="XM_010705900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJ99"/>
    <dbReference type="GeneID" id="22572534"/>
    <dbReference type="KEGG" id="lpan:LPMP_080720"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000034200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_080720"/>
    <dbReference type="eggNOG" id="ENOG502SM0N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273637at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="317" mass="35482" checksum="F2E240ADFF80C3A8" modified="2014-11-26" version="1">MSHERHHTSRTGDALVAHRPHGPASSVAAPVERRMKVDPCTNARSMYQRGPDGSEMYASYYNSNDDPTFQKRFNSHKNGGAFVQSAQFTFMSHGGAGDGSQLPGYRQRHHGARQEHPRHPVMVEESMDEDMHEVRSDTGDDTDVHAKRRANVKSQSTKGDPIVEEPDDDDKGYHDSGSRTHRHGGKKGERGSYRDTTHDAYPTNTSTFLMDPWGVESIMERMMQPPLGFGDPFIYAPQRAHAQSGRRPPSASYGSKRQQLIPYTRGGVMGGPFTDDFFGIGSPENPFCMMEAMRHHMQQQRAAMFGGTDPFARVFPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJC5</accession>
    <name>A0A088RJC5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_100130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696735.1">
        <property type="nucleotide sequence ID" value="XM_010698433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJC5"/>
    <dbReference type="GeneID" id="22572749"/>
    <dbReference type="KEGG" id="lpan:LPMP_100130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100006500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_100130"/>
    <dbReference type="eggNOG" id="ENOG502S64H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="250177at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="285"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="359"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="432"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="135"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="296"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="432"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="457" mass="49668" checksum="AC8DA84D1D978DC5" modified="2014-11-26" version="1">MTVENKIASMPNPPPLYDFEVEADQLTRKQLEERVEQMRAANLVLRTSVLRLRESLATLQEGMRANYADLERRQEGISNMLLRRLEATKHHHSKLVAHLRTVEAEKAMQEAKLHCTMQSINELSKHLKQEEQQIANRLQHRLLRLHAQREQLDQVLEEQTSSLQQLEQLVQEVEEMDQSDAAERGGGCLGTHTSTAMPVLAVVPASGAPAASSGVFGPVHERSSSRLSAASSTTATNTADVAYDPTAMIRYLTDEIAAAEGLRTEALSKAEKYVAMRERLERRLAREKQQRAEQQSRTQEIHQQLQDASTAVNEREVAHAMAVEMEMDRHLNSSRFGGDIISSASSTCATPQLRAVSTVASRGNSASPGVSRPCPGPAAQDPEGRPQDTFVLPNSSVCSGSAGSTGHFDHLGGTSSAFSGIPGVVTSLGHAPAAAPAMEAADGPVHSNPTERTDESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJF1</accession>
    <name>A0A088RJF1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Membrane transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_030340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009372">
        <property type="protein sequence ID" value="AIN95269.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700977.1">
        <property type="nucleotide sequence ID" value="XM_010702675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJF1"/>
    <dbReference type="GeneID" id="22571900"/>
    <dbReference type="KEGG" id="lpan:LPMP_030340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_030008400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_030340"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015360">
        <property type="term" value="F:acetate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071422">
        <property type="term" value="P:succinate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047623">
        <property type="entry name" value="SatP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30178">
        <property type="entry name" value="INNER MEMBRANE PROTEIN YAAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30178:SF3">
        <property type="entry name" value="SUCCINATE-ACETATE_PROTON SYMPORTER SATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN95269.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="359" mass="39712" checksum="C324772265A804CC" modified="2026-01-28" version="2">MSNANVSTFNPQTWAGEHVFPSMRDTSAVTHVFKSCESLADQMRDNLRSPRSGVSYNYLTTYEGIQRLNTVDSGLGRQTRKKPSNLRSCDYLDEDQNRALSTRHTRSNNCPSARHGDSSCFDSDSDEEERLINHQIRMLEAKQAAANMCKSANPGPVGLLGFGLSTILLNLHNTGRFPLSTVIVAMGIALGGGAQVIAGLLEWVRGNTFAHVAFTSYGTFWLSLVLVWLLPNTAARSSSIVEPASEYFVGVYLVLWGIFSFFMLMCTIRMNVAIFIVFLTVTLLFLMLGFANMTGNQTALRVTGYEGVICGSTALYLAFAEILNEVWDRTILPVIPMTQLLDWLGSKEDRSVTTSTKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RK77</accession>
    <name>A0A088RK77_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_111290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696976.1">
        <property type="nucleotide sequence ID" value="XM_010698674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RK77"/>
    <dbReference type="GeneID" id="22572994"/>
    <dbReference type="KEGG" id="lpan:LPMP_111290"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_111290"/>
    <dbReference type="OrthoDB" id="272406at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN96323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="481" mass="52320" checksum="DB4B0AF45C1D6B82" modified="2014-11-26" version="1">MAAPPSIVPFHVATHKLSFHGAVKDWKTVVQRIVEDLNTDVWCLQDTSARHLKLLPDGFRATGSRGITFVSRSASVQLHAVAYVNMASLLVKASQQCIAVTDSIPVSTHHLCKLPLVVGFAAWDVTGQRASNAHGVVGRVLVVNVDFERVRSWSTEFQSSLVYVLCRQVWGDVNSYTQQWGCRHVCFAGSFFFAPGSIPYTMLTSHSGGLREVVNSVVVVKPFACCHFDEVHGGGSAAAKTFNMCVVARVAQRIGEMQEVLGIHFGGAKKSKMPVRELQAFFRRDTATTYSSLELIPETEEGWWKVAKPLDTSVSQEVMLRLQWPAEEMDESNTASDLSPDLTPRIHLLVRSGGVLPPQCQEMEGLVGVCSPLLSSVMAGTCAGKKAVAATAELEALCLKRGQVLQPTNGISAECGEPVITALYRENVPIPPGCYDYIFVSTFTGITVESKLAHDAMDFAQEQLTAHLPLFAHLVLPASIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RK93</accession>
    <name>A0A088RK93_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein kinase, putative</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_120150</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="EMBL" id="CP009381">
        <property type="protein sequence ID" value="AIN96343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696996.1">
        <property type="nucleotide sequence ID" value="XM_010698694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RK93"/>
    <dbReference type="GeneID" id="22573021"/>
    <dbReference type="KEGG" id="lpan:LPMP_120150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_120006300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_120150"/>
    <dbReference type="eggNOG" id="KOG0594">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4236">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272515at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="9"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="469"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="476"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN96343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="585" mass="64066" checksum="6858E1FB4B4DD822" modified="2014-11-26" version="1">MGDHLGSRFTVIEQIGSGNYGSLYRAIDGEAATLTDRIIATKKLKDTMNHPHVLREVSVQRHAQQCSPHIVKLLHVVPRDHVRAALVLEYVPLDLRTFLNAFYCDRAKSSAPPWCAAAGAGALKPVSTPPRHIPLIYVRRMLRGLVEALHCLHSRGIVHRDVKPENILVEPLGLGRPLRCVCPPMGSSRTAGEAAGCWVHAPHSPHPQEEEGVTQERHRPGTLESCQFFCQNSVALHHELTGDELASAIHRIHCETCRRCPHAPAGVQECVLQRHEDSSRVAAGTFCSQERQAGAVDKEGSAKMDEDEEDKCAASTPPPLVPDVKLCDFGSARHIGTLRLRSAEEQREELTPGPTTPVYCAPEMMLLQHYGTSVDMWAVGAILYEMLTGEFFLSVGTLRSFSGNVIVQDDYCVMHRLNRMFLHLGTPSLDEWRSIAHPLYYPDEVLAHLPQVRDAALFRCVAQSISPPERLLQDSGDGKANGDTETTDEQKDLNVQPPAGPCSCTPQASVNGATDSNVATASEPCYGMPGVPAPSSLSDFLYQRTGASGVDFLLSLLRYDPAQRMTSAEALRHPFLNPEGAKGYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKA6</accession>
    <name>A0A088RKA6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_130270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96457.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697110.1">
        <property type="nucleotide sequence ID" value="XM_010698808.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22573137"/>
    <dbReference type="KEGG" id="lpan:LPMP_130270"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290030100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_130270"/>
    <dbReference type="eggNOG" id="ENOG502RZQK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272753at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN96457.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1888" mass="205423" checksum="17BFD4526364E250" modified="2026-01-28" version="2">MFEGCLQLCLEFIGAQVPCVGCSSAQLSEFICEDVLPYQGWVANDTLRDTIVRLLLTTQGSEFDVCALTAKDEIETSCAERVDVAVSAPGSRQGRGRRRAMPAPAASNTSPQGRRVSAEEAVVLLDLGRIVWTEEEKCVSCDQRGASGQDRPQGFPSSRRDGDPNTLLFFTPSHALRERVMGFSITNEKLEMVSSFIAENAVLGWDRLPSTPAFKARYKNYLVGSGLKWLRRMHKVTLVYMYHEPSRGVVYRFFPHFALPLTEREKKGHLTWVAGAGSDGRAPSPSREDEQLYGEWGRDSGGCDGRALSATASTASAPLLQQRCTCRSHYPLDHYYARKRRQEAAFPGVAFDLQLVRQLVQQSPERRLLMQDAVHAILAAHGLFLTRWEDFSRTERMHLRRLMSVAGLSIVVASVTLRGHLRELRIVIPSEDLVQQVYTVPLPASPSETSSTSVRPRARVRDGGDGGEVKAEKMQSLHLNGSDGDNDDAEDVHDGDTNCRDEAALRGKVVSAPVILRADRELGHGGAAEELDFDDHEGDGSRDSTSGEDDDEQGDRTQSHAAAPFSHPSTRHQQLEAVAVLRAEPNQALELQAAHEAERRPLSLTAAVPRVQFHMPYKQRSKALGAFLERYAKMRGTLVTQYLLLRHTKVFTLVYAPRPPTGLLAQGPHPVEATAATVVKGEEVDDSFRASEGVAAATAADTAVVAAEVALPLLPPRTLHFESSDPRLPKGLSAYSVNTVLDVLVQAAPHYAASVPRLMQSIDVSTLNRRVLPFLRHLKYVHTTAVAQRGRKHVGLVVLLPAEGETRPSTLSDAAKQAVLDAEAAVSAEFTRKSARQPVLPSAASGKSIPSDMMLQSLPAVMNGACRSTLGERLVEVHPAATKAVNRVMTVRNGYARSLVQRMSRLHLELWHQHYRYPPDSAAGGAGGVRVREMYTRMSLSTFVVVVGLPQADLGRVLGRADGVCDWSTPLRDLPPSVYGWCVQRGTQTLFACLQGLYDRQLIRSPQCGFNSFSSEACDDVVYALEPQCTVDGYTHYFMSAPPTAAASLYACMRYWLPFWSAVGRTPHRLSSQLLALESNAAVVQVVALSKLLRQDPSFLAAQLYQSSGLPLESRRSTSLGDVAADAVRRGADRRGVPGRSSVSSSASLFAPKRHGRGDDGDNTSPAATTAAGSHHVAEQRPHKAPRTEISGPTVAEALESAFHHFAPLRRVNEVMRLVLRGRSVHLSHHPLFCVPATLPAVRVLQHGGVKASDSLLHPSSGGGCRGTGTPTEFNMTNSGQGGGAYNRLVSTSTTHMAVLAETLCAVRGSNAAHRACQLRHSSSTEELCEEVESVYAPQAAASTAAVATADFALAHSCAASAPLSLPQLSLLPSPQATEMRLSPPSTQQSQLRLMEAGFEVAADILRMIVFCDQAHYRASVARSLLTAFNTPWLVSRARAFLQRLPVFRRARQQNVRVPQLSLAHSPYILPLNALRTAPHPCANMAVLHQWVQEADTLSGAVTGGRESPTMLWAHGEMNSLLASGAQEPLQSTQPPPLELLHQPSMDQAYMSMAMNAVRERMTRLPLPQLAWPADAVACEGLLRRRPDSAEGAEANVTGVVVGTVAARRARPHRKRRRSSAARGSKEASNGEEDTDNSNDSSDDGDSVAVARAEVEAARQLYPARTIRNYGDPPYLQNIPIDGPPTAAEQRAVEACYEALRGGAFAPFSPLSPLYDGSHTPEGCSLIPYPSIFHHVDGSWHSYMWHLVVHTVYRYILCVPGIRHADLEGRLMASGVVSQRALWAVLRFLMDRRLLLCHEEELAQPLCTPGGGALGDPPRLRSPFQLRKPSRPDAAPSLPSSLSAPIGELQFTNRQRGGAPGNCCYHPTIPLEGLRLVMSPRLLNPLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKM7</accession>
    <name>A0A088RKM7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_120570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009381">
        <property type="protein sequence ID" value="AIN96385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697038.1">
        <property type="nucleotide sequence ID" value="XM_010698736.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22573063"/>
    <dbReference type="KEGG" id="lpan:LPMP_120570"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_120010300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_120570"/>
    <dbReference type="eggNOG" id="KOG2076">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9991317at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001001">
        <property type="entry name" value="Hypothetical_protein_-_conserved"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039340">
        <property type="entry name" value="Tfc4/TFIIIC-102/Sfc4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23082:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23082">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIIC TFIIIC , POLYPEPTIDE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="755"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="949"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="500"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="863"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="950"/>
            <end position="966"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1360" mass="148301" checksum="FEF5D01ED2F8FA60" modified="2014-11-26" version="1">MPLKRNEIANSVETGRSAAAVKRRREGQRREFSSSALHSTFEAHVTAAQNAFLRGDSQAAEQEAVQALRIRPTAHLFALLAVIAESKGKFDQASDFRLLQAFLARDIVLWEELLHDFMTQQLYYKSVVCLQRMSALEKNQERHRALQLQLADLLIGLGEIRRALNVLVPLWNSSRCCDFEVFAILSSLYFQLGKWASLQRLIESSIKHAFQLLPAADATGAIATPGEAVGHGAEATVQVRSSTPGAEQQPSSPLPDSSISGRQAVRRVRFFGVDVSEGGAAAPVTTDLTTSATPMSSSPAEATLDEFSFDDVISPASPFSDLASLHRPRNVAGSTGVDQGGVVHQLYGERIELRTQQDQKNFLTLVNVHAELLSEQGSFSDTVQLLHMAAGCLDVDLMELPPDLLVRLGVAYAFLGGVYEQPCRDVFQHLVEHCSMEDYGDVLLDAAMSLQKVSMHAEAAQLYVTLAHYHQFVYDRVRRQVGVAEAELALMQDTAPWNKVQAATDALKALKAEEADLRTVLAAALQGQAQSAYARELYEEAKEYAERVLQLESTHLQARLLLGRYYFYQRKDTTAAVEVLTPSKDEPALQRIQLGVFLVHVFQHAKRYVEAIALGVSIFELLLSSEEDGDTQSVAPGTSSRRSGASLYLPTVTRASSAIIPASSLAGMVGGSASAGGSNVAARTSFSLAASIKASTSVARQQLSRRGLESLTTTAYGASAAASLAAGWDRRKEEGQLKDTSTIFRFNRRRRRPTVGRGLANGDILTDEVPEGPAGDAAVQGESGATRLKAAEERRAAVISMEPGAFWPAEEEGEGGRAEDDQPASSRVKAEADKSSATQSIREEAVDDGGEDRSGAEALHSPVKREGGGDRVGDTAIVATAVVKASSGIEGKGERQKTKRESSGGAVVGRFNNTIMGERDRDLEELEGFLTAAEAIANTEGGLAEFSGNAREEVPASERDEQHDETVDTLPESYELPSLEEVSKQFHDPTMAQLFLDASSFTPGGGVRGGEGQESTPDPWADLEANHNANVVARFPPGTGLEDRVTLREAVAVLGKAGFISLAVAIVECYSAVGQFTEAREFAFVSLTHFAQKRRLRQMGNGLERPLRLAVLRAALAAGESEDAYRVGLRLLQQDTAEDKRHEVVELMHSVLNRCYDRSSILYRAVADGYNDPALLVLLANRYHQTRSYTRVLNLYLMALRERPADILLNFMVGLSYLFCSHRKRTRSREACVSAAIYYLTQYQQLRLALEPTVGIGEVLYNIARTLQFLKLYYLCVPLYERVAYDLCQPEECTIALQRAARVNLYFVYRWASGNRTLALSALQPRGGSNGMAVVSSRPPSPFTLKTDGEVLNVQGQRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKN9</accession>
    <name>A0A088RKN9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="10">2.7.8.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LPMP_070230</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the CDP-alcohol phosphatidyltransferase class-II family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="10"/>
    <dbReference type="EMBL" id="CP009376">
        <property type="protein sequence ID" value="AIN95709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704031.1">
        <property type="nucleotide sequence ID" value="XM_010705729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKN9"/>
    <dbReference type="GeneID" id="22572358"/>
    <dbReference type="KEGG" id="lpan:LPMP_070230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_070007200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_070230"/>
    <dbReference type="eggNOG" id="KOG3964">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250191at2759"/>
    <dbReference type="UniPathway" id="UPA00084">
        <property type="reaction ID" value="UER00503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09137">
        <property type="entry name" value="PLDc_PGS1_euk_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016270">
        <property type="entry name" value="PGS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586:SF1">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10 14" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001838987" description="CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase" evidence="12">
        <location>
            <begin position="21"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="13">
        <location>
            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="43"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="648"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="652"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIN95709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="756" mass="81791" checksum="3721FEC5F44B37FC" modified="2014-11-26" version="1">MPVLLVYFILLAIAAGATFALFGEVAEADVAPTDALEFFSAATPNSSSTTTSSLSAASSPDAAAGMKAGDGDRSVCESHATPADESGITHIKALLMKCGVPLQQQEMVSFLARHCCILPVKSHTVRVLSHPTVFYEELKKRVMAAQHSITLSALYIGDGPLSRAFVVCLEERVRWAAAGGHPFSITILLDYNRMLDRKNLASLKTLMELAQKTASTASLPVDAASAGANASSLTALSSSSLGSSSVFDDGELSVAEGVDDGSSDVASAATTTPSAAASTGVRVRLFLYQNPSRWNRLFAPLGRAKEALGVQHTKIFVFDQRHTILTGANLSDDYFATRMDRYMIVEDNTLVARWFTRLVNTVNRVSHPVVCRKEFAEQLPGGGAAHGSRTPNKGCGLWHASHAASSFSGEAAAAVSSSAPAPLPSPVAWMVERVSRAVSPLWTSVVPQREGSPTLHRKSDLVILSNALKIDPSADTGRFCARTNSLLHDFATWAQRMCAAENVDWSCYDTFLFPTVQVGRAGVYHDSVIVKQLLRLSTAEEHIFLTSPYLNMYASFVDELLHGTSYVDCITASVQTNGWNGQAGMAGRIPLFYLQLERSFYYLMKAYNCLRRVHIREFSVKGLTFHAKGLWFVGRRCQSAAVTTLGKDGEDDARQHHDSHGADAAATDPCAPESIAAPYLVAYGSTNYGYRSVHKDVEAEAFVLTTNDTLRETLRQELLFLLHKSARVTETQFVGTAVGRFQPVISLMAHLGQDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLF4</accession>
    <name>A0A088RLF4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_091040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN96019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704341.1">
        <property type="nucleotide sequence ID" value="XM_010706039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLF4"/>
    <dbReference type="GeneID" id="22572674"/>
    <dbReference type="KEGG" id="lpan:LPMP_091040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090015900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_091040"/>
    <dbReference type="eggNOG" id="ENOG502SIU9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267255at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="318" mass="35201" checksum="4FA96C0573B966A4" modified="2014-11-26" version="1">MVTADTVANPIARPSCEIHTSNSTPVRCSQISARAQKARTTALVSPQPVLLRNPYSRDRPCLVDAPHNDGNTSRCAYQHGRTSSSHADVEALLSRQNAVLYDACVTRLRVVRQERRVLTTTLEASKKRLEGVKVLLDAWSEKPRQPPATAQTEQAEKAGEVREPQSSNSPRTQETEKMVRQLRALDRANDELRRHYEALEREKKHCLTVHKARLRRVLTAAAPSSTTSRRPSAAAVWDESRGSTRSATFARDAQTLDTRLTVAMAQQQALRQELELVMAKERGRMKALTDLQARGFASVHAPDQSGSAITTALRKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLK0</accession>
    <name>A0A088RLK0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_160630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN96937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697590.1">
        <property type="nucleotide sequence ID" value="XM_010699288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLK0"/>
    <dbReference type="GeneID" id="22573641"/>
    <dbReference type="KEGG" id="lpan:LPMP_160630"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160010300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_160630"/>
    <dbReference type="eggNOG" id="ENOG502R0A7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273097at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="377"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="565" mass="65314" checksum="D6A08FB655EA0629" modified="2014-11-26" version="1">MRLQRQLQDLLQLPRNEVQEMRQRMQDPDIAIPLLQCYDAVIREKTEEVERLRRETVGLQTQLDAFHRDQLDVSNAVRMAEELAKNVQDKAAAEVQRYLEAVREMQGELVRLRLEMTRALEAENTAKQDALRTAERAASLETALEAAKRATSKAEAAREAAERKVRVQEQHAAEEQTDSVVQKTQLEVMTQENAAKAQELERLRAKMMQALRQASDNHAAHLRVVEERHHTIVENLRSVNRTQEMEMLKLRAQLARWDPTNPSGACRGAGASSPPTSLRFQSTTELLEAQARQAQELELKRLYGEVSTLQLQRNDAVRQYEQRTARLQRDCDQQLQDVQRQLQSAQRSLAEVRSRCEELEETKATQEASLRKARDELRQAQQDGQQYRLSADSHARKLASAQQQLAEANERLSALQREKQSAVRQAQERASELESNVAQVLQEVQSAKERAYVEVGEVQRRYEELRMQNSKLQDGLREREAALAKKERERNILEVQLGRLEEGLEAHKRRIVEADRRVQQLEQQLTETRQQHRGSFLSLEQMKLQNAQLTRTRDQLTEMLQGRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLU3</accession>
    <name>A0A088RLU3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_160330</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Nibrin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN96908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697561.1">
        <property type="nucleotide sequence ID" value="XM_010699259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLU3"/>
    <dbReference type="GeneID" id="22573610"/>
    <dbReference type="KEGG" id="lpan:LPMP_160330"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160007500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_160330"/>
    <dbReference type="eggNOG" id="ENOG502RAQK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="552194at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22667">
        <property type="entry name" value="FHA_NBN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000017">
        <property type="entry name" value="Nibrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040227">
        <property type="entry name" value="Nibrin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12162:SF0">
        <property type="entry name" value="NIBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12162">
        <property type="entry name" value="NIBRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="10">
        <location>
            <begin position="24"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="402"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="528"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="585"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="747"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="782"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="822"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="972"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1237"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="426"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="590"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="610"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="686"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="826"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="848"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="994"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1079"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1097"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1243"/>
            <end position="1263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN96908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1263" mass="134705" checksum="F28E7FED1E573B66" modified="2014-11-26" version="1">MYLLEVNHGDGEIHRHFLLPDQTYTLGRKVCRILLPVAEPSISRHHATIFVASMPRYSVLDPSAQLEIRIEDVSKHGTFVNRERIGKDNSRFLYPEDLIRLGLRVTARIIPVMLVLAISPDLTDASLDLVLDSCVRIGALVVEDSIPAPLSYYEAHTDCIGFLYVAENSFTMEETMMVALGYGYTLVTPHYIANLVRSLEKKDTLMPGEFPSPSAPLPASQALRSAHYRRPTQTFFSVAEFLSVGRPMAATVFCGSTFVLLESALQEVYSGVLRLFGGTVEVVALDAVGAWCSRQSSPPPLPLTTVVLVGEEDFRSVSDEVIKRDGGRGAFPTKHARPVICGYLTMYKCGLCLIPEKNVHLTLYRNDSKELHAKAKSCFLQRSADDVLADAALSPAGDAPLRLSSGSFTDTRSTSHHGSTIRTSESPASASPSPVAAMSPAPVIARRSRDSSFIADHSPNRAEKAVNGTAAASAATAAPAATTASPTGDVWCLTGSRAASPNFVSSLHPVHSTRSASASPQPTSVVLATSSSGAAARQSPPTVAPAPASAAAAPPLAHLDETSHVQDTATSVPLTVETPVATTTVSFSAGAGGGGGGGSAVLRSRDRAADTSSTTMATNTLSTALAPQRMSVNSARRNSHPFSLSARQRSSGGDSDGEAEERAHNCTGIPLGSKEAEGSQGRRRSSSSSIRRASGSLHRLSTDNSLTTLPLRSEEVACLCPLGRSVSLPSGVAAAGTLLKHQSCATFEERPQRPSPASSEEPRCDSAPEEWCWRNNAAVTESAPADGAMPPLPPSSSTSSAIAGPTTNVTFAVPVLHPAGRPKSIPAQAAPTAATLTGKPEVSKPQRTEQTNGSATARESEVAQQLLSTRRGEQCVAYTSASETRCGLAQLKLPLDSVRNGAHHGGKRSNFRLNSARRHVEQYTTLEHDVIVHTASQASISSPRQRVEAVRIGSLSGRRTSVSHDFEFSLSRPIEPTENGAGDVENKRRVVRRSPSSLQRLDSSQARKMAPPHRLMTPRATSSVPRNRRAQAYGGVPQSQSARGTEDGVAHKTSISDVTARRGSARRRLGSPTQGNGMSASSSSTLSAPRQIPSLHSGSVTSSGATASSGAAESYLRISKELSAHCQRFMSEFLDNFMSAMERTTRCAVQRSHIDFSSRQMLEEGVERILEFLHYINSTEADIPAVYSTPNTRVACHQVWQKSQYVLSKIKACYHAVNCKAPSVLIRARAALSTRTAPPLQQRRFTSVSGRGQSRSPQRMSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RM19</accession>
    <name>A0A088RM19_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bis(5'-nucleosyl)-tetraphosphatase, symmetrical-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_170540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697745.1">
        <property type="nucleotide sequence ID" value="XM_010699443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RM19"/>
    <dbReference type="GeneID" id="22573797"/>
    <dbReference type="KEGG" id="lpan:LPMP_170540"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170010900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_170540"/>
    <dbReference type="eggNOG" id="ENOG502S28V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10267127at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006798">
        <property type="term" value="P:polyphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050126">
        <property type="entry name" value="Ap4A_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42850">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42850:SF4">
        <property type="entry name" value="ZINC-DEPENDENT ENDOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="27"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="312" mass="33103" checksum="976DD3610E46BAF2" modified="2014-11-26" version="1">MCIPAALRLDPLTESASPLAEDGAADDVCVFVGDLVNKGPDSYGVVRCLRNIGAIGVLGNHDAVLLRLSEKLRADVPLTVEETSSSLYPLAMGCPDDVFTFMASVPHILCFRAYQLVVVHAGIDPSISLAAQGVEAVTRMRNLIKATKYGRGSMSEAAGQRAHVALSLSAAFAAMERAKFGTSWCATWSKLACKLSRAATGKEESDSGEIDSGSDRSSTNISGDVAEDGGVKKPKKVDGGGAKWRKRIHPDYAGFTIVYGHDAKRRLQVHPYAYGLDSGCVYGGELTGLVWPSTLVSVPGWANPSPHHKSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RM25</accession>
    <name>A0A088RM25_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Las1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_160200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN96895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697548.1">
        <property type="nucleotide sequence ID" value="XM_010699246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RM25"/>
    <dbReference type="GeneID" id="22573597"/>
    <dbReference type="KEGG" id="lpan:LPMP_160200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160007300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_160200"/>
    <dbReference type="eggNOG" id="KOG2425">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10263222at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090730">
        <property type="term" value="C:Las1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007174">
        <property type="entry name" value="Las1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002:SF0">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04031">
        <property type="entry name" value="Las1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="321"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="38658" checksum="233091CC13654A48" modified="2014-11-26" version="1">MRRSQVSEARRRQALAERRFRGHRIRSGLDELGDLDAPKKRVERKDSTAALTETGDSSVTERATTETTLSNCATTGIPIPALFSTVFGEDWREWTEVKRVLFDMSATAAAKRSALGAIHIWRQRARKERELPAYVESTEVLLDAMLQDEEDALKDGPLRMCYGAAISRVVHIMTGSFASGTADTYRKRASEIGFPEEAVEVRQRVAHGALPLTSELRWVCGLVLQFLFTQYWLEQERQVYLMQHAQASSSSAAGGLRTALQRQSVSASAATPATKTSALAASQLPPSVTADDMRALLRELESDEDGEGTQGGGVTDRGDRAASGTSSPAGPAQVGEGTARQNASAGSSVTIAGWRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMB2</accession>
    <name>A0A088RMB2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_171040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697795.1">
        <property type="nucleotide sequence ID" value="XM_010699493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMB2"/>
    <dbReference type="GeneID" id="22573847"/>
    <dbReference type="KEGG" id="lpan:LPMP_171040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170016700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_171040"/>
    <dbReference type="eggNOG" id="ENOG502SB9X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264247at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="452" mass="49800" checksum="2B97D5D316426964" modified="2014-11-26" version="1">MPSQSLQPERRTSRFLTSCPGADPAVFRLTDHAVDNVEYATMQLLVEQRTELPARDTEAGGSDGRASANVHPQHQEESRNGESAEVIDWPDVAHFTHLTSPIPLAMDTMPTGLALPQQARIATAEERRVRLLFHSRPHIRLTKRPQVVANAVLDRPRWTQPLCYPPLCIPCLHNAFYSVPLSTVMRASWEPVFSSWQPSLAFSDSERPILPRREQPSGNLSGAVNVGSRAWATSVTAVMPTTAAFYHVPITAPLLAQSTMPDRRAGGELLLHPEPGTSLSNPLSHIHTRTVASLQEARLSAHNETTGCLARLSHKCRHFVYRCFCVRCAIASQAQALQADAEMRGVKAVPFPCCTCLGVESKSRSELLTTLCLLDLFTLGVPFGCCCYHGLGSALYGWHLRYMLRARYRIFAWTSMDLLIVCCIPGLALDQQGAELLLNGTPESTVGLQFMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RME8</accession>
    <name>A0A088RME8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleoside triphosphate hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_170500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697741.1">
        <property type="nucleotide sequence ID" value="XM_010699439.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22573793"/>
    <dbReference type="KEGG" id="lpan:LPMP_170500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170010500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_170500"/>
    <dbReference type="eggNOG" id="KOG1969">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2195431at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF3">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="426"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="44"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="189"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="288"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="985"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1151"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1239"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="253"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1161"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1245"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1272"/>
            <end position="1290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN97088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1334" mass="142796" checksum="9D27B62A16688C0D" modified="2014-11-26" version="1">MDLEEASRKAVAEDEEEQQQQAKARIAARDGPYPSLCFSYSPPIFPDASGSMKRKASTYPEDEQAEDGHDGGEEADDDTYDEFSDKDLLQSVPFANDAVVLPPFGQLSPPTSVPTGITAAAATAMQSTSSPRPATDSATAATLASPPPLLASPRGVLEFPPLGIASFLVRGDDGRVRWVTATGGTAASAMRKSGAQAPQAIGHSGPNEVVNSEASDKEDDAVGVHENGGTATLSSSGVAMVLSEGDEDDMSCMTPSSMHSEASNPTGFLRDGVKVRAMLRDIYAEEAKRQQRQVEEEEQERPNAQRAAAGLGHSKVEAFGEGDEVLDDEERERRWLVGPARQCRTAAAGAFPRHRPHSTSSNGELWVTKYSPKLFREVLSDETINLRLLQWLKSWDAYVFPDEALSAAKGVSTLTAGAVATPSPPAERIAVLTGPPGVGKTTLVHVLAAHCGYEVIEVNASVERTASRLEAIIKTAVSAAGPAPGGRVRRPTASSAVVGAQVSALDHRAPLGDEAGYRGAALDAETAAASSWSHTSSSLVHHLLRPKCLVIDEMDGIASSSVATYLIQQQLHRPVFCLCNDLFVPSLRPLRQRCSHVYYMPPIHPQRLLARLEEIARREGAVMFDSLALPELIKTSGGDVRSCLNAMQFINSIVHQQQQRQLETGTGASSSATAEPVVTAPSRHTVMELIRRMQGKDARAALRDSWQLLFIRPERNKAVQLLKQEFGMDYEAFVEAAAAQHNRNVVPARRALERERAIGAPAGEGSAATRTEKMRGVDDASACAATQPVAVGFRVDPGYLYAAQKLSRCSDNSSLVDGLQENYLNRAYTDYTFSRTSATADSFSQQDVTVAAAFQHPGLMGMAERLFQVSALTCYVHCSTAARGGRIEFPREQATLRRLQSESKHVVQEFCEGCRPYSSTFLGGDEVISTDVVPMLLRCLFDRSLRLPAHAISSFSRLPPADQRLLQASVARHVEYGLNYQRDRQYTPSPAVAPAGASRSPFGSLTSASVEDEAPWRLTPELDKLLAGVVRPVEHALGRSGSVDHRGFFFSSRSSRFGGNGADPRGSRSLPALPFSARVKGGTGSLTYATGSGGGGCSGTASSPSLASVMMPMRNEVRQILFGEIHQYRIMQSMELLKRSSQQPAMQELRLAESTTGAPERGAKRQRAESDVSASTASLDLVRRGDVTMSGGVHQVEHVTAASGAGELDAPAVKCPRTDEASTVPAAVTATDTVRRDFFGRPLPSTDTAQAATAWTGSTARNGGHTGGNRRSTSATGATMSSSSLTPLSSGDAGKGRFPRPHSPHRPIVRAFVRYVYQDGSTNAVKIPATFADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMS7</accession>
    <name>A0A088RMS7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2HC/C3H-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_180070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697841.1">
        <property type="nucleotide sequence ID" value="XM_010699539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMS7"/>
    <dbReference type="GeneID" id="22573897"/>
    <dbReference type="KEGG" id="lpan:LPMP_180070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180005800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_180070"/>
    <dbReference type="eggNOG" id="KOG3940">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265955at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001258">
        <property type="entry name" value="Uncharacterized protein TCIL3000_10_13860"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025874">
        <property type="entry name" value="DZR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026319">
        <property type="entry name" value="ZC2HC1A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049899">
        <property type="entry name" value="Znf_C2HC_C3H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13555">
        <property type="entry name" value="C2H2 ZINC FINGER CGI-62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13555:SF65">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12773">
        <property type="entry name" value="DZR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13913">
        <property type="entry name" value="zf-C2HC_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52027">
        <property type="entry name" value="ZF_C2HC_C3H"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2HC/C3H-type" evidence="7">
        <location>
            <begin position="89"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="C2HC/C3H-type" evidence="7">
        <location>
            <begin position="232"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="C2HC/C3H-type" evidence="7">
        <location>
            <begin position="582"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="C2HC/C3H-type" evidence="7">
        <location>
            <begin position="684"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="115"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="193"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="257"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="523"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="624"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="260"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="296"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="532"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN97188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="721" mass="78041" checksum="33A842860FBFBE77" modified="2014-11-26" version="1">MLPALAGPKRVGHRPQFRVCYLCGQQFGSASIGIHVPQCYQKKLSQWEGNDPAIRGPKPKHPDTVKWKGGNGVSVEAINQEQYQEFNAQLVPCPHCARTFLPDRLPVHLRGCKGDGKDIISPSKTKAGGGAGGAPGRGKRQSEPRRSPRGRSLSPGPPLLPTCYLCGQQFGTASIGIHVPQCYEKRLAQWQNADPRSRGQPPKHPDTVNWRGRSGASAREQSEEQFQEFMNNLEACPNCRRRFLPDRLVVHLRSCRPDNPATAASPSKAKASGGLSSRTPTTAAVSAETVATKGSGGDERRRTEKQQESRQRPTSFASEDRLHPKHNRLPCNSALPAESRVCPQCGVVEYDTYTKFCRDCGHHFVSKQHSNPCQHCGEDIPRGSCFCGTCGQPVQGAPSHRRTPGGTNEGVSTARRLVCPACEALSDADGNFCDNCGAALGDADVAPATAAAAASPSSYTGRSTECKTSLYCANCKEAVEDKKALFCEDCGGRLEVLKVPPTEDGGSPDSCNNTLPVTNMARLSTAKVGKPQESTSRARAKNSTPAATNVASPTSSAMSNLWHPQEEDGGNELPAQTESDVERQPCRHCGRRFASESLGKHEHICASLKKRRVFNATKQRLAEGATAAAKVSPAPQPKAPTRDWKAESVAFRRAIREARHVDQVLKAGGTIKDLPPPTYSINPDYVPCPHCQRRFAPDVAARHIPRCANTVNRPKPPPRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMX7</accession>
    <name>A0A088RMX7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNaJ chaperone family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_140110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697247.1">
        <property type="nucleotide sequence ID" value="XM_010698945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMX7"/>
    <dbReference type="GeneID" id="22573278"/>
    <dbReference type="KEGG" id="lpan:LPMP_140110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140005900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_140110"/>
    <dbReference type="eggNOG" id="ENOG502QW5K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="66964at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050817">
        <property type="entry name" value="DjlA_DnaK_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="444"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="525" mass="59156" checksum="EA1DB3F04A9DF06F" modified="2014-11-26" version="1">MWNASTSAIARVRRNGVAQTGLTCCTSLASPQRRFSSWFEEQPVRGQQHTEDKAVAAFAINADKLEKSKTIINKKAHGIPFHISDNEAVDNVCRHHGTAVEIHSVERFLMPFWLTETAAAGTFKADILQHDRTNITQPHCFVWLEGPRYQFSYPFGEYMPMNQVSASYREPLKVVERCLTGTHVPSMLLSRFELLNEVEKMEHRPTVIPFTMSTITALSVMERRVSRRVVMDRIDRELRKFHGSFLKSNVTVVNLRMAASSIRPVFLPLLKLTVTTVSHSTPVPAFICGATGKVVGPVLHVQRRKRLGLAVSAVAGTLLSLAPLVEPGVATAAALAAGVSSGFVLQTVQQAHFMRKQAHEMAQLRSVGVLNLVADSAGYRWTPEEEEKDEYEYREELRRQARARDAFEQRVKEEAARDQARARGNHFDPKNRRRTDLADVDPRGYYELLGLKGKEVSATTKDVTKAFREAVRLHHPDLHSEAEAENKKRHMQRIIEAYKILHNPKTKKSYDSGEMSGKSHETSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RN63</accession>
    <name>A0A088RN63_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ras-related protein Rab-7b</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_180890</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697923.1">
        <property type="nucleotide sequence ID" value="XM_010699621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RN63"/>
    <dbReference type="GeneID" id="22573979"/>
    <dbReference type="KEGG" id="lpan:LPMP_180890"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180011800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_180890"/>
    <dbReference type="eggNOG" id="KOG0394">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1436450at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002682">
        <property type="term" value="P:regulation of immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01862">
        <property type="entry name" value="Rab7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000751">
        <property type="entry name" value="Rab family GTPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF20">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB-7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00067801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN97270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="223" mass="24037" checksum="D5D16440907B5B8A" modified="2014-11-26" version="1">MPMKRQLLKIIILGDSGVGKTSLMHQYVSHTFDSRYKATIGADFLSKDVEVNGRVVTLQIWDTAGQERFQSLGSAFYRGADACILVFDVTQQESFAHIGSWMEEFSIQAGRRDSVLVGNKTDLEDRRQVASKTVQAWCAKQNAAAANANNGAGAGADDSAAPEMKYFETSAKENAGVEDAFIAVAQLALAKKATVEETTPMPQTVNLNQAQTPQTTSSSACSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RN85</accession>
    <name>A0A088RN85_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">200 kDa antigen p200</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_181140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697948.1">
        <property type="nucleotide sequence ID" value="XM_010699646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RN85"/>
    <dbReference type="GeneID" id="22574004"/>
    <dbReference type="KEGG" id="lpan:LPMP_181140"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180014700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_181140"/>
    <dbReference type="eggNOG" id="ENOG502QW9T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="250544at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="709"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="928"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="125"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="275"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="438"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="812"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="972"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="719"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="745"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="781"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1024" mass="115158" checksum="8D90A1CB94CCB4CB" modified="2014-11-26" version="1">MTTDALLARAHQQPLPPEQQQVHTRPAEGDVQPRRTSGAISSILGRPPPAPQVATNTFAEPSGGSYLYSYPTPQRDSPASSSLVVPGRHPSLSPTSTVDYIEIEHKQNELRHAVEHHVQSLERSLALRDEEVATLSSRLRKLEEDYQFNYNLIAERDAALEEASGQLQRLYRELKRLTEESTHMEKQIDTADNEIRAARQRVREVEEERDAAVRQVQRDYTIKERHLAEAVRAKEAALEKEQAEQHAWYKERAKALEEERAVMADRSALVSIETEDRFKQQVARLQSEVAVLQQALKDARQQKANTEKRIVAMEEANTALTHESVVAQQRHETFAQEAALTKRDLEDRLVRVVGDAEKRVLAAEATAREEAGRASCTELERTRLQSMLAGAQERLQLLTTRYDEDVARFTKERQQLLKSSDEAMAATTSAEQALHDTKREMEQQRRLAAEEATRLRREVERAQEMSEAIHQELVTAQESSREWKAQAQSLEAEVRRWKTEENKTATNGRLECSAWEEKCRQAEHQVQLLQEVTQQAKKTQQGAVEQAQAEVVRLTRELHASEAARRALEDQYHLQEDYRDGRDGLQMLRMEREQLQKRVAELEQTNAEVRLQVANFAAELQNDPVIKAAKETQQRAVALQQELEQARAEIQLLQDSLRDKDEGLVRLQTEMLRVQVLVAGDETESPPLDMQTHLATGASTLTDHVSRALQRRQQQMRSEYSRMRESYEEMVRELDRQRRRRRRPAQPSRTASVTSSSSTNSSSARGAKLSERHRKGGDGGPSAAPGASVPPALPDSKTAHLLQESEVWRQRCVQLEQQLLTVLRERDRLKKELQLAKQDVVALGAEKASLVDLNSLLKAQLREAYRLRLGDTNTRLVRGPTTTTPAASAPDVRISPQLLAAALQALEEGTAAGDDTESRPRVCSAASAEATLTQHRSRAEEASGMKGPPVVHSTRGYAGASSPSIASRSISAQQAQERLTTLEHEIEVAREQLATAARMRPQCPDGQAVIRRGSAAVRHYGLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNI5</accession>
    <name>A0A088RNI5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Plastid-encoded RNA polymerase subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_190630</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">In plastids the minimal PEP RNA polymerase catalytic core is composed of four subunits: alpha, beta, beta', and beta''. When a (nuclear-encoded) sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698058.1">
        <property type="nucleotide sequence ID" value="XM_010699756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNI5"/>
    <dbReference type="GeneID" id="22574117"/>
    <dbReference type="KEGG" id="lpan:LPMP_190630"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190015100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_190630"/>
    <dbReference type="eggNOG" id="KOG1521">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270173at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07032">
        <property type="entry name" value="RNAP_I_II_AC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.120.12:FF:000027">
        <property type="entry name" value="DNA-directed RNA polymerase, alpha subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033901">
        <property type="entry name" value="RNAPI/III_AC40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF13">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="8">
        <location>
            <begin position="121"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="66"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN97405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="445" mass="47888" checksum="4606C3FDF86E1F4F" modified="2014-11-26" version="1">MSKSRRDMDKVQLGYHRAENTETVSSPHTYAYNSSKSVPSTAKPDKPTVSNIRIVSAVAGLPPSAFAAKASGKREKKEEEPESVTAAEGSPSSSSTLLYDAASGARTTVDGFPWSTRRVERMSFELQHVSPPISNLFRRVLMTEVPTLAFDRVLIEENDSPVLDELLSHRLGLIPVAGPVMKMQYITESNQASFTNLDPSRILLFELDAMGAKDAAVTPVYSHQLQWVPLPGQEKKGGAKVGAGADARGAGRGGDAGAAEFNTDDDDDAVFLVHPDILLTKLGPGQRIKLKAIAVKGFGAVHAKWCPVSACYYEMKTSVELCERLTGSAAEALVKSCPAGVFGYEDGQKGAAATVLAPEKCTLCRECLRSDDNAGAAAASEDDRVRVQKDKTHVIFHIESVGQLHPAQILRFGLRLFAERCRALAEIVQSTEVHVVDASAKLLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNR0</accession>
    <name>A0A088RNR0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_200960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97588.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698295.1">
        <property type="nucleotide sequence ID" value="XM_010699993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNR0"/>
    <dbReference type="GeneID" id="22574303"/>
    <dbReference type="KEGG" id="lpan:LPMP_200960"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200014200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_200960"/>
    <dbReference type="eggNOG" id="ENOG502S6EI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275288at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97588.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="107" mass="12395" checksum="3D887E5F0D91C151" modified="2026-01-28" version="2">MGQSNGAALAKDTAAAEQFLKYHEARHRAVHRAFVKCVVPSSKGKDDGYGLTPEERLCVEEFAILYAGFAKREFLHFTSLYEQYQRDQLEKMRLEMMQQQARKDIQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNV3</accession>
    <name>A0A088RNV3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Adenylate kinase, putative</fullName>
            <ecNumber evidence="6">2.7.4.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_200230</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the adenylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6"/>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698222.1">
        <property type="nucleotide sequence ID" value="XM_010699920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNV3"/>
    <dbReference type="GeneID" id="22574230"/>
    <dbReference type="KEGG" id="lpan:LPMP_200230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000028200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_200230"/>
    <dbReference type="eggNOG" id="KOG3078">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001381">
        <property type="entry name" value="PRK00279.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="5">
        <location>
            <begin position="123"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN97515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="218" mass="24315" checksum="C2CBF53A69D56676" modified="2014-11-26" version="1">MKIVLMGAPGCGKGTQSSYMKERYGLCHLSTGDMLRDAVARNTTNGKLAKGAMDSGKLVSDDIVFGIVKDSIKNPECRYGYILDGYPRTLKQAKMMEDAGEKIDKVIDFSVPDEVILERTSGRWVHKSSGRTYHEVFRPPRTPGKDDVTGEDLHQRPDDRHDVCEKRLGIYKQETRPLADYFTKEGVYSMINANQTVDEVRKVITALLDPIGVATGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RP72</accession>
    <name>A0A088RP72_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_201160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698317.1">
        <property type="nucleotide sequence ID" value="XM_010700015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RP72"/>
    <dbReference type="GeneID" id="22574325"/>
    <dbReference type="KEGG" id="lpan:LPMP_201160"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200016800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201160"/>
    <dbReference type="eggNOG" id="ENOG502S497">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="193300at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051493">
        <property type="term" value="P:regulation of cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000059">
        <property type="entry name" value="RIKEN cDNA 6430531B16 gene"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010441">
        <property type="entry name" value="CH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052111">
        <property type="entry name" value="Spermatogenesis_Ciliary_MAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12509:SF9">
        <property type="entry name" value="SPERM FLAGELLAR PROTEIN 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12509">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06294">
        <property type="entry name" value="CH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="8"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="223"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="177"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN97610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="263" mass="29744" checksum="E069CA155881B614" modified="2014-11-26" version="1">MASIPFTEEDLHELYTWVDEIPISRPKRNIARDFADGCSVAEILKFFFPKLVELHNYVPAMSHAKKLDNWNTLNTKVLRKLYFEVPPEEVEDIIAAVPGAIERFLRALRLKVAQIKTRRDEMIMMGEIPGCERMQCANPSQVQLHPRGDHARDDGGSTAATYRGSKRPSSAAPPPRSVSSQRSASADLQAASRQAQPQRQPAALAVNEEASLAHVVREKDYTIQELRETVVILSEKIVKLEELVRVKDEKLSQYRQKFGRMPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPP1</accession>
    <name>A0A088RPP1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4456 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_205710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN98062.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698769.1">
        <property type="nucleotide sequence ID" value="XM_010700467.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22574783"/>
    <dbReference type="KEGG" id="lpan:LPMP_205710"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200064400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_205710"/>
    <dbReference type="eggNOG" id="ENOG502QVSN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272766at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027914">
        <property type="entry name" value="DUF4456"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21444">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21444:SF14">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14644">
        <property type="entry name" value="DUF4456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98062.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1685" mass="184535" checksum="867E8FBD634AC676" modified="2026-01-28" version="2">MNSSLPTLQRPSPALPRKHVTGSPPGAATVQRAVGSSTLHERLVTRHREAIEAFRTSARSFNNDVDSEQQERVALLHTAVAESHATTLSTIAQEQQRLAERQAETQAHNEALRGADPDAVLPVCADVYHCSTADDQGRARAVALMQQDRLSLMQRLVEVRDHYRSRVEAIDACFADIASAEEARRKHIQAAVHNLMDSLTRIAVTSTTESQVLAQRILHHTNEQLGGNYLAAQTMATQLRQRELYKHQHYQRTLVTIYRDMQMCMAQQHVAWCITVLRSALFRRPEGRLQSVQAAGRLISAIRSEAEGLTRGLTEVVDSLEVAQPSATTTELQVCGGSGTNGWLRCFESNVHRPIFVGEDPRAVLEEWQMRVSVLLRHCRARCNELILRVRTDEATRTSVAAELAAHTLEDVEAIARPLGEESGLLQRASLAYSGTDKDGSEGPPGEAGDMLDDALLSLTHAHPGVLAMKQSMAQSAAWALCVPTIEQEGKWFVHLVSGGFRRGYIQFCADAATSTGSMLVSLEGATDVLLASTCGILGNLRELYAQWHEKEMDYRDEVTRLELQLRLLEEELRQQETPAAAETQYTAGLMCLQSIIDAHTRYYEAVRNRVANAAADVLRVGQACVGELSRQAGLSWIRLSSSDVGEALETPQEQLKHNNSADTLRTTTHSSGTISGVLLSSPHKNGAAVVPTSDARPWSTTHGEEFIIDSIAFRFTCVTARSGGASSGNSTAKADVSLEDFDVDDKAASAGAIPGAACQQFYLDLLPELHPAQQDAALFLPQSRVVEWKEKLRHALMEWGLNLQRRAWENWRLYTTAFQADVQRRVMEVLRYHRRRPATLQANVYEARVRELMDTKNRGDKMLSQIAERVTHLQTLKHDCITQLSQTGWDEAFVRERTALIGKVRDAMSKKAVKTLVCRHDSLCAEYRTALADRCAEAVHTLERARAAIEEDCAQLLHDRAVELRGGNKTAQLPAGDPVQRAVDQLRAEVQGMLTQSLKAVDDLQQERVAEIESWQAKWDRTVEHSSAELSVFQTAQEGLARLKTQVQTMLTTAAMEEAALAAEVAVVVKVVDEASVVPVIDLAATMHALFKEDPSATSPAGVHDGETPLTTEDLKDMVEHKLNMAKAMQRDRIRTASVCVVFASLDKLRGLLYERGCRLGLLAHTVEMWRVSPMHYLLPSALGEEDPEVMRSRAGNRSAALKAGRRCKDAQSAASAGHTIMPLSTPATYAEQAAQWTTQVLKDAEAAALRHVSAFPGDMYRRLPGMTDGSAEQFNAAVATLCLAQRERIKSYTTKAGQPFRQRVQELWNALQRTPSLLAHTLRTEATTAILERVGAVLQSWLRFQRQSSEQWRAHKNAVTLSLAHQPSATALTSLSKAEAARSASAESTLQKVWGWSLREVEDEVGLHVARCWTALQSYSRLLKGLVTPQHLVSTADVVEGSHHRGLRHLLELRAQHERAATELEGTTGVKRDPCLQDLISLHRADAPGANPPAASKRRVSSSAAAATAAAAATMESVTLVQLSQWSDIELPGLPLNACVPLSQYNMQHPQTTIAPPLAAAAYVPAATHLTSDGKGPQGPSNRRISGMTSSASASSSGRKGHSSTAADAKVAAAVAEVSVPLLVPRAPLALECAQLLRAVVQSVSSQGNDAAGVLSNTFDFYERQEAQWQQTWALTLKDLATM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPY9</accession>
    <name>A0A088RPY9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_181280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697962.1">
        <property type="nucleotide sequence ID" value="XM_010699660.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22574018"/>
    <dbReference type="KEGG" id="lpan:LPMP_181280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180016100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_181280"/>
    <dbReference type="eggNOG" id="ENOG502QWPK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="245907at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.30">
        <property type="entry name" value="Phytochelatin synthase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038156">
        <property type="entry name" value="PCS_N_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="224"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1426" mass="156074" checksum="195689D0AB1D5CAF" modified="2014-11-26" version="1">MATPMNANDMKRMTRVRLNPTTRIASVPMSPVLPYADIPQSNDFQASTMPRMETTKLTSAPVAPSDHHQAVQAVQTAYEKTEAHLKTIEAKLSLLHEEMQRAASLPTSREAPIETPSSNGMARGALGSLAPIATNGTSGRTAAVKHHLQPIPPAVATPLPPVTPARVSKVSRVGKSTASPVTAVIAEPSANAVAVVSVFEKPYQQHDPLYPRFSIDGANLLESPKASIGSDSSSENGSRGSSSDASCTLPAGAPQSVEEPARPPTQAFPAAEEDSKPSQGTVTPVRQGVRSKGVSYANASSSAGAADNHGVIKFSGDESETITRDFAAWPSSTASPLKCLSWGAVETGEVVAVGREFRRISCQASTSGGEAAHLSVGGVCKDVVANGQAVHGLRNATRRQTFLVTHLQELFFAPIPRFSDVLTCSEAGLFNKHDVEKLMLPGASCSWLCCASLAISYVSGVPTPVEKVLRANRMGVHYISFPTITLAELFDVVNDYIHTCYHRTSVHNGNCTEDEFEDDEEAAQYLSEDEQKELANIHCEMAIFDNDILDPEFGEDIHGMGEHPPITSMAQFRKELLLHLEEEKSMYIFNYNPYVLEQSQMRLRSNHCDTEEEAAMIMSTARFPANTTGLFGILLSFDSMKHEVKVLTPYLSAEQHSLPFKDGEEGHVRHFASTFANFVMEEQVVSLQAFYESVHQVDSYLHLSRGFVRVFKSKSFTPKVPSIFPLFVLDGSSAGGLTTGVLNVTIAPHVLGLAMLHHLSVTFLLTDSARRKQSSRNLLSKANVCDVKLRGIPLTKVCQQLRLPLSMIVCESNRSSIEAAYVWYHLFLQQLQINQDVRIGLILPSRRDGAADGQPNMTDSEFLNHLHLIVQSQSVMLISFDINIALNLRIDARCEPAHFAIVIGVDGERGIVRLADVNAKRFRKTWHIPASRLYNAIMGYGYIVASKDKKVIKSLNGKQFHEDALQCARNFLPPSTPAVHQRFEYPSCPYPVTVLADAVERLGFAGTNVERFLNFCGFHISYFLSHDMPLEGAAFAIQNYSHYALDDAVSVTTMHYDFCEENPPPKEEGAEVGVTPTYPVRSEADFLQAIQYAIADPAKRKLIVKYDLSVLQANAAVWNGNDGSGFAFVMYYEAPTKTVVLSDASPSSFYRSFACPLTVLFSAVCSWDRVDLRGRGTILLTTEVTQESVYEGAKGYDMAHALVHHPFKPIFSAVFSCLALASTEIMMNIETPTLLGGAPVSIEDEEKRKYRRYNNIFSAEDFLYTLPSFNVCEWRMQSVDIHDIVSMANRAFATLRLPLRAVDVLQETGAHTRADPKALLRACSGVNGVLTIILVTYDTGMLHGVPGWSAGLVNRVHFLDDESGDEESEAKLMVPGAPENSAGSVQLLEGDPCRWGACSECSAEELVRAVKGIYRVEEVIDDGADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQM0</accession>
    <name>A0A088RQM0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_221270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699129.1">
        <property type="nucleotide sequence ID" value="XM_010700827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQM0"/>
    <dbReference type="GeneID" id="22575173"/>
    <dbReference type="KEGG" id="lpan:LPMP_221270"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220016400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_221270"/>
    <dbReference type="eggNOG" id="ENOG502S6AM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="243549at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="267" mass="29084" checksum="D7FD956117A1FFE6" modified="2014-11-26" version="1">MSLGEMSMSEVPRVCSRLASFQSSAKPARVVVTSARCTPTSTVAAAASTAESSGKASLQQEMEQCLSVDVAKMVEMGKKLMAERQCFYAEKFFAKALRTLDAVAADVNRIAASREDYNGSVALCLAWAGLALMVQGEQTVENVYLARLGRQATLQPYCDEPLSDANRAMTTWRLMQGAPRPWSETRDSEAKLRATLLSNAQDTSARSLLVITLFLKGDLERAMTEALKLHVSGDAFGRVALKHMSRFLGKDHILVQRLGSPDLTESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQM8</accession>
    <name>A0A088RQM8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_221370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699139.1">
        <property type="nucleotide sequence ID" value="XM_010700837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQM8"/>
    <dbReference type="GeneID" id="22575183"/>
    <dbReference type="KEGG" id="lpan:LPMP_221370"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220017200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_221370"/>
    <dbReference type="eggNOG" id="ENOG502RT7Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275798at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="228" mass="25866" checksum="DDD415AD00145B13" modified="2014-11-26" version="1">MAPSAAKKWPTFLLEKHTSLNPTMYLYRFAGPHGPGPYVMKYWWTLGCLPTGLGRPFRLSEFLAEYQQQHVPIEVEEWLKCFVRNPYEELADATSELLKYLEEVPRRENTRGYRSIESGVSSFAAPLAKFERQLNVRVPSLALRAALGSASLRERLKDDLFEYRESLRLCGSTPHRRLARFAFDELLTLPRSSGDPGSYNGPGRQRRARGASGAAAVSGPPRRFPRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQN3</accession>
    <name>A0A088RQN3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="12">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="12">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LPMP_221430</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>tRNA(Ala) + L-alanine + ATP = L-alanyl-tRNA(Ala) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="12"/>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699144.1">
        <property type="nucleotide sequence ID" value="XM_010700842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQN3"/>
    <dbReference type="GeneID" id="22575189"/>
    <dbReference type="KEGG" id="lpan:LPMP_221430"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220017900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_221430"/>
    <dbReference type="eggNOG" id="KOG0188">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2423964at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070143">
        <property type="term" value="P:mitochondrial alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00673">
        <property type="entry name" value="AlaRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.130:FF:000015">
        <property type="entry name" value="Alanine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.310.40:FF:000001">
        <property type="entry name" value="Alanine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000011">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050058">
        <property type="entry name" value="Ala-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777:SF9">
        <property type="entry name" value="ALANINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777">
        <property type="entry name" value="ALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 12 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 12" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alanyl-transfer RNA synthetases family profile" evidence="13">
        <location>
            <begin position="6"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="602"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="606"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="727"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="731"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIN98437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="962" mass="105984" checksum="73C912F4636EF7E2" modified="2014-11-26" version="1">MSFIEWPVSRVRQKFVDYFKKQGHTFVPGSPVCPHDDPTLLFINAGMNQFKTLFLGTADPNTDFGRLKRVANSQMCIRAGGKHNDLEDVGRDTYHHTFFEMLGSWSFGDYFKKEAIQWAWELLTEVYKLPKDQLYVTYFEGDVKNGLDPDLEAKELWGQFLPESQIIPGNAKDNFWEMGDTGPCGPCSEVHFDRIGGRNAAGLVNKDDPMVVEIWNLVFMQFERRTDGLLTPLPQKHVDTGMGLERLTSILQGVKSNYDTDVWIPIFEAIQTATGYRKSYVEIRSEPDSDALVAYRVVADHIRCLTSAVGDGVMPDSVGRGFVLRRIIRRAVRYGVQFLGADPGFFTQLVDSVCASLGPFFPHLKDPRNIQRIKAVLADEEQSFAKTWEMGLKHFNHAAGECRANNSRVISGSEAFVLHDRYGFPVDLTCLLAEKDGMTVDLEGFNAEMKANQVSAGRVAAAKTFIDAYQLEDLKKRAIPQTDDGAKYAWEDSTGEVLAIFDKKNSRFISLLEPGNDLGAEEVGIILNATNFYAESGGQVYDTGRLVAARDCVFEVKKVYNVGGYVVHVGKLSKDSASPIPLSALVQMQVDYERRLPIAANHTTTHQLNWTLRRVLEENPANFTEVQQKGSLVTDEMLRFDFSHHTKLSNEDLVRVEKLLNEKIQADLPVYREEVPLAAASKINGLRQMFGEKYPDPVSVISIGAPINEMLANPEKEEWRDYAVEFCGGTHLSNLKEAEKAVIISEEALMKGVRRVVVATKAEADKAIKAGAELKGQYDELVKREATVGNIKALSVLNKKVGDSCVPLVLKNAMRDNIDAAIKQMNASLKMQVAEAKEKAAEAGKALGASYDAAAAPFFVHQMTEFGAEREALQAFSDGFSSTVSGPVGVFLIGSDDEKALAIVSMPTAFVEKKMSAVTWAKSSIGKGGGKPNAAQSGLPAKDAAAAAAKATAEAEKMKASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQN7</accession>
    <name>A0A088RQN7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Exosome complex exonuclease RRP45-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_221480</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699149.1">
        <property type="nucleotide sequence ID" value="XM_010700847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQN7"/>
    <dbReference type="GeneID" id="22575194"/>
    <dbReference type="KEGG" id="lpan:LPMP_221480"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220018400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_221480"/>
    <dbReference type="eggNOG" id="KOG1614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264038at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11368">
        <property type="entry name" value="RNase_PH_RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033100">
        <property type="entry name" value="Rrp45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF14">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="8">
        <location>
            <begin position="55"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="9">
        <location>
            <begin position="253"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN98442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="363" mass="40179" checksum="AF8BC48650F26F65" modified="2014-11-26" version="1">MLYRTAVPVPADALVQRNVEFTRTAWKAGLRPDQREANQLRVVEINFPLLSRDVVQVRCGNTVATATVNCDLVEPSPYRPKHGFFEVHARQLLHERDPLDQSKEIKRISMYLTRLFTGSVLETEGLCVIPGRRVWSIDAEVIIMNNDGNVQDVGQWAVMAALQHVRRPELTIRGDDVIVHPPHEREPVPLPLHHIPLSFTFAVCANPQEVQLAVRASTLRRGQTPRAGASSDANADEDDGEEKELGWSSDALQVVVDPALEEVAAAACTVSVAVNGEGHVCSLEKADGCDVSIACLEKCMETATKLTQALLTQMKESMEAHNLKRKETVRSQFLWAQQRRGIQAVATQEEEGESASKKAKAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQX9</accession>
    <name>A0A088RQX9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_220850</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699085.1">
        <property type="nucleotide sequence ID" value="XM_010700783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQX9"/>
    <dbReference type="GeneID" id="22575131"/>
    <dbReference type="KEGG" id="lpan:LPMP_220850"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000029500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_220850"/>
    <dbReference type="eggNOG" id="KOG0589">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08215">
        <property type="entry name" value="STKc_Nek"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="44"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIN98378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="358" mass="39991" checksum="5A05F19010D31DFB" modified="2014-11-26" version="1">MQSSTFLPEQRHLSSKSGPQNHHYVNPLVSSFPTVVGPKLPCKYRVRRAIGRGAFSTVWLLIDNKTGQTVVGKLSDASHSSSASKAFATAEVENMRCCSHPNIISLIENFEAGEKSLYILEYANAGDLQTQVDTRAQPPPGTNDGSPIPYREDEVLVIFAQLGLAIRYLHDHRIMHRDLKTSNVLLTRSGLIKLGDFGFSRQYQESVSGEVGNTFCGTPYYLAPEMWQRQPYSYKADIWSLGVIMYELLALRKPFQATNLSELMEMVTRQGSFDPLPEELYSSDMISLVKQMLKVNPSERPSINEILALPLFQQRGLRILTINVRRIKNLDTEVRARLVEDVGAVLGDNDISDAAPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRY2</accession>
    <name>A0A088RRY2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_250320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699604.1">
        <property type="nucleotide sequence ID" value="XM_010701302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRY2"/>
    <dbReference type="GeneID" id="22575680"/>
    <dbReference type="KEGG" id="lpan:LPMP_250320"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250008400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_250320"/>
    <dbReference type="eggNOG" id="ENOG502SV7B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267700at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="90" mass="9479" checksum="44F68B1C1A4FA2EF" modified="2014-11-26" version="1">MSAAKAKDTEAVPAVHEEDTPTTARIAAKEASGKALPPLNLTPAERRGLLIVVGVALLQEVHSSVFRWALVGAASAAMVYKSFTRPHQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RS97</accession>
    <name>A0A088RS97_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA polymerase delta subunit 2, putative</fullName>
            <ecNumber evidence="5">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_251440</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase delta/II small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="5"/>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699714.1">
        <property type="nucleotide sequence ID" value="XM_010701412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RS97"/>
    <dbReference type="GeneID" id="22575792"/>
    <dbReference type="KEGG" id="lpan:LPMP_251440"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250020100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_251440"/>
    <dbReference type="eggNOG" id="KOG2732">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3763at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.50:FF:000012">
        <property type="entry name" value="DNA polymerase delta subunit 2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040663">
        <property type="entry name" value="DNA_pol_D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024826">
        <property type="entry name" value="DNA_pol_delta/II_ssu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18018">
        <property type="entry name" value="DNA_pol_D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA polymerase delta subunit OB-fold" evidence="4">
        <location>
            <begin position="2"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="3">
        <location>
            <begin position="205"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN99007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="554" mass="60027" checksum="A2DAFF4CC9EC210B" modified="2014-11-26" version="1">MYRCRMEAQYASALRAIQRIVREDPRYGSQAYVMNPRRVLELQPGVPAVCVGIVYKNMKLLPRFLDEYQSELVRIDAGDDDNDDESGVVEAVPLDRSAETAAATMHRSNEAEEDANNDGQALAAADEHYSVCDSADELMLEDSSGRALLQGLDAERFCTGIVLGVYGALLPNGSMKVLRYAFSGDLGSAFVPRPVIRATGPCYIAFVSGLSLNVPRDNGKEEQAAASRARASLELLVEFLCGNTGNAALRGKAKCVSRLVIGGDSIAPTDELKLKKKVKLDPSDHVRLNDDKAQGNTVTSAALMRQLDTLLERVVRTVEVELMPGANDMSDAFQPQQPLHPLLLPKAGKHSTLRLVSNPFCFTAQPGAATVATTELLKSEECVESEAKKHKAEVAEGVNFFVTSGQNINDVARESRFPTRLDTMCMVVVSGCACPTAPNTLFSYPFCNHDPFLFQNTPHCVVACDQPQFETRYATLDELHEETHHNFTESASSSPRLKATASAVSAKGDENKAVLPEAGVRLICVPSFARSGALVLVDVNSPTLETSVVSFLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSA8</accession>
    <name>A0A088RSA8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Calpain family cysteine protease-like protein</fullName>
            <ecNumber evidence="5">3.4.22.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_251540</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.-" evidence="5"/>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699724.1">
        <property type="nucleotide sequence ID" value="XM_010701422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSA8"/>
    <dbReference type="SMR" id="A0A088RSA8"/>
    <dbReference type="GeneID" id="22575802"/>
    <dbReference type="KEGG" id="lpan:LPMP_251540"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250011800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_251540"/>
    <dbReference type="eggNOG" id="KOG0045">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="424753at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015232">
        <property type="entry name" value="DUF1935"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036310">
        <property type="entry name" value="Smp-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF423">
        <property type="entry name" value="LEUCINE-RICH REPEAT PROTEIN (LRRP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09149">
        <property type="entry name" value="DUF1935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101601">
        <property type="entry name" value="Smp-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="4">
        <location>
            <begin position="165"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="active site" evidence="2 3">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <feature type="active site" evidence="2 3">
        <location>
            <position position="414"/>
        </location>
    </feature>
    <feature type="active site" evidence="2 3">
        <location>
            <position position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN99017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="704" mass="80018" checksum="8F8E673C33B9B185" modified="2014-11-26" version="1">MGNACCGCCYPTPEYKLSRPRVSGKSTPCFDNGNLFKIVKGGTWYFYNDTQDYQMKVTVNFGDGSKVIALSDTHLVTKNDYGACTATVSVFPLETKAMVKVKKTNDFNVKFSGIAFTEVDRQKLHQKAAAQVSADLAKMRKLREKNPKVKNQNQLLKVARTEGNMYLDTSFPPTSRSLIRPGIDSEPDACLKRPETIAWRRPEDFLPKEWHSKIRLFSDISPKDIAQGQLGDCYYLCAVAALAEYDAAIKGIFKNHHWCYIRNQEQKYGAWRVNLNISGWWRTIIVDAYLPSVQLLPVFARNRNHPNELWVSFAEKAYAKAFGSYQAIVAGYPWQALEDLTGFPAYDFGDAWKTSQTDTEARRRLFDSLHRWNEKKYLICIATPGNGNLKMGGKQLSANEVQALFEKAGLSTGHAYSVLDVKHFPLHHLCMLKIRNPWGSQVEWTGDWGDDSPLWNHYPLIKLACRPQKKADGTFWMEWRDVSMFFDSGSVCLRRGNWFHSWYDYRVPGNFEDLVCDTALEIIVNKTSVFPAYISLHQKDRRGLPASDPDKKYAAVMLSISKGDINGSQQKVVANSSVNPEEPSTEYLFQQSRSVSLFYKFTKGHKYLVIPRRMNSTGNNVPKKYVIALHTQSKVSSKNVHVNIVRLNKNNAVFKNVTSFDAGTLTSLTTVYQTKDGTSVFRTYRSDNLGKGKKQRNAEFELIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSD1</accession>
    <name>A0A088RSD1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Electron transfer flavoprotein subunit beta</fullName>
            <shortName evidence="5">Beta-ETF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_250130</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ETF beta-subunit/FixA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699585.1">
        <property type="nucleotide sequence ID" value="XM_010701283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSD1"/>
    <dbReference type="GeneID" id="22575661"/>
    <dbReference type="KEGG" id="lpan:LPMP_250130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250006400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_250130"/>
    <dbReference type="eggNOG" id="KOG3180">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276685at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046395">
        <property type="term" value="P:carboxylic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000011">
        <property type="entry name" value="Electron transfer flavoprotein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN BETA-SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294:SF8">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="6">
        <location>
            <begin position="29"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN98878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="258" mass="28448" checksum="B2C62C634FFBD580" modified="2014-11-26" version="1">MFRTLPNYLKVAVCVKRVVDYTVKVRVKDNKVQTANSKMSVNPFDEIAMEEAIQLKEKKIADEVVAITIGSKKAEEVLRTAMALGCDKAVHVVVPEAAEESLESLAVAQVLQKLHEEIKPDIWVLGKQAVDGDFGCTAQLLAGLLDIPQGTFVSKVEVTNQKITVTREVDAGRQVVELSMPCVLAADLRLNTPRFPKLPNIMKARKKPIDTKDVAAFGVDITPRLTTETVTEPATRKAGIKLKTVDEFYDKLHEAKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSJ6</accession>
    <name>A0A088RSJ6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_250900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699660.1">
        <property type="nucleotide sequence ID" value="XM_010701358.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22575738"/>
    <dbReference type="KEGG" id="lpan:LPMP_250900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250015000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_250900"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7451790at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF56">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="314"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="467"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="549"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="899"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="950"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="687"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="749"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1109"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1257"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="321"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="467"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="490"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="511"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN98953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1305" mass="141189" checksum="C2C1B770221BF476" modified="2014-11-26" version="1">MLSLRFLSVHMNSIKVLESGCLRTLRHLVELDLSANELREIPLGCWDGLGRLERLNLSSNRLTRLGPTAFGSLASLQWLSLGFNSISDVVGLRSVPAHAPLTYVDLCANRIATLDEVIDALTPHRAHLQELRLESPSSMTTAAVDGGAFSPSATTNASLNDSQGGVPDYWPIKENPCCLSPGSVMQGASGGRVEGSSCAASGQGNSRVSGAACSSPVTTGYVERLLSYFPRLLVVNGVSYGVDPLQALRQQRQSQEQEGLQGEEANAVGVTVAVADASPHALRCNADKSPQAGAERLDEDTPVSDAFARLLRKPLPHLRRSSSSSSRSQSSASFEEPKKQYRNRSHRRTSSRHRTRSLSHRRSRVTSSSSSSPQESPRHGHRAAVAPTSAPQAKQDPQAPPYSTGVPAPQKASEMDEESVVAAGAPGKKRAPLRHGQWAAAAKPRRASLRRRLSSNALSYATSPLSVTASFPSAVSPSTPQEHARERKPQTSVSPSNTATPHMRKLRFEPTSVTPTTEASRTPSATPLTEQLMPSGGKSADLAALLGYPSPAGVTDTSDVSPPAATTHGQCEHRDGDGESGSKGLSVATTTDGGAVTPVTSKDWATHGLLSPLVGTASAVALRWKPKQVSRGTCTEQDTETLATVSCDAELAAKVEQLQAQLALRNTTISDLRRHLDLTRTQYVEGQREAQQRQQQLRSQVSALKDELARRSEEATILQRKQQAQLNRAVDFVKAEWGRRLEVAEQHSVEALAEAAGAWEERLARAAEENLHVQQTVTVKSAQLATLERQTHAMEAEMQAMRGSAVMQRRHGAARTELLLAEAEKRRSLEAAAATTAVQLCHSFCNAAVRLHVEALREADRGRQWAEAALREQQATWRTQVSAYEDAMRHAASEVHSAVMGKHGAAHLPPLPPTCKSPARPEAPPLSLAPVPSPTLTGVAAPQLELLELSGDSSDNKATCAQEDANEKDDKRARTQLRVERAAADDSALVSTPTTGSLLATQGEDSSRAAAAAAACGAASDALRQVTGVDANDTLTKYWRNACARIEAQLHRVAAALHVATCTQQSMAAENTRLLSHVEALEAEKEALAALRSTSGVAVQERDNLLRTLHTLRADMEKKDAALDALEAEAHAKLNEKRHRIVELEDTVEALTMQQTRATEEHASMRGQLEAARATVERLQQELADARERRRAMTQQQAEQVPDLERKQRELSELLATRNAESHQHQLEKKMLVHTLTIARQQLVRLYESHQHLSSEHTSAKEQVTRLQTKLDAAQRQLHDVQEATLAKQKATLEVLSHLMTNNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSL3</accession>
    <name>A0A088RSL3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_250350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699607.1">
        <property type="nucleotide sequence ID" value="XM_010701305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSL3"/>
    <dbReference type="GeneID" id="22575683"/>
    <dbReference type="KEGG" id="lpan:LPMP_250350"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250008600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_250350"/>
    <dbReference type="eggNOG" id="ENOG502S9ZS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="258495at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="CDD" id="cd11709">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050672">
        <property type="entry name" value="FBXO45-Fsn/SPSB_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245">
        <property type="entry name" value="SPRY DOMAIN CONTAINING SOCS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245:SF5">
        <property type="entry name" value="SPRY DOMAIN-CONTAINING SOCS BOX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="475"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="702" mass="75108" checksum="23D3A63EBE755550" modified="2014-11-26" version="1">MISEEGFLTALPFSGGEQRLSQHSSAIPLRGSPSPVRSASALFSYTEAATPTWYSALSASALYPSTYPLDLYTSSAASVSHAVPPSLSYNPYKYGSWADPAPPLDSATAAAPSTESRVHAALGEAERQRQILQLERELAEEQRQRLEARLSLSSSSSAARLSASAPGSKVSSVEAAVAEPQRTASEASVSPPLEVTYDEIGGELRGFSMETPAPPSSPSPPSAHVHTRRHVHGAGTHVDISGPDAASNMRPQEQHMEPCASPSPSLAAPAITTDGFDGLPGVSLQPQPSQSLSPRRCSPERCTPTMKEALPCVTGEQSTSAHITRHGASSPSPKRAPMPAEKRCTPVRPAPSPPPSEGDRSHASLCNPHSAHREVADIHEDEEHQYDVYRQKLARIQEALRPSSTSGVLCQTASLEAHRAHQRRCRLTTPALWPSAPPPPRQGPSPYLFKISVETTPPLSFPPHHATGELPLVRRAPSTESYADSVAPLPRGRPRQLCWDLAHSGNVVMSSDGYACKADATDALTLIEREYHGRLEDVLQRLVIPFYAMGNLGVTRGSLTFAFRWASPALTHRASVRQRRDRGGSGGVAHRTPALAFGFATRAFTGYGTEAPAFLYLSTGAIAQGVSTTTSAGAERPYGAPYEPGLELAARLDLERGELEFYVEGVSMGVAFRFFPARHPAPLFPVVVFSADRDAAELLYSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTL7</accession>
    <name>A0A088RTL7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_231450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699301.1">
        <property type="nucleotide sequence ID" value="XM_010700999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTL7"/>
    <dbReference type="GeneID" id="22575350"/>
    <dbReference type="KEGG" id="lpan:LPMP_231450"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230022500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_231450"/>
    <dbReference type="eggNOG" id="ENOG502SKMR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267899at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="656"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="403"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="677" mass="70511" checksum="A62B878FE3DA50AD" modified="2014-11-26" version="1">MQSPHSSLGSSLSADQTRHNTKDRDTRRNTLRAVQPSPPPHVPKRAMLPTFTPLSTTATRESDIRAAGYRGAPQASTRFPAAEMATAAQEELAMSHLRTPDSRDSSTLDRHRRQSIDLPPQQQRNLLQRGVGADMTPEALFTCIRLRPGTTLAEASGVPHNASVSADRYRNGSVSGPSGSSGRNESQLSIGDSCSPITLVVNSASASHANTNTSNATSVGSASTSGSVRFDLTTSTPSARAAPGSVAANNTQPKASSSSLMGQPEVVTSPLSAPHQALSTSLSGESRRRSSHSRKDSSAPLSAKTSISMEVPSQPRLSHCESSAGSCYTDIGVSSSPRPVVNRRVHFLLDEPEGGDLAATDHLTLPLRSSGDTRARLPLCLSTTTVSPTPSDTDKRLASNANSSSHTRLSLSGSSESFSERPQPGFSLGGAAMRPAASSLPLHPSVAPISQSGGASALSLHLNRKEGRIKAMTAFSQAESTSSNGTSATEVGGLSVNSAPSTMKTAAGSCSDAWSGFSGTHASATYQPGQPLPKPALKQVSRYSNDWNAGDSHAPSKLLTDSRSQWSRWRSIPSGGADMTAAAPPASPSSMSVMHRCFTSYLQRAFIPLEQGRGRDAVAPSATTGRAAGAGTSTTLYSSVRTAGSRGGGVELLVKWTLVSVVALVSFMLIFVDIVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUN5</accession>
    <name>A0A088RUN5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_251210</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS25 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699691.1">
        <property type="nucleotide sequence ID" value="XM_010701389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUN5"/>
    <dbReference type="GeneID" id="22575769"/>
    <dbReference type="KEGG" id="lpan:LPMP_251210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250017800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_251210"/>
    <dbReference type="eggNOG" id="KOG1767">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10263513at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000678">
        <property type="entry name" value="Ribosomal protein S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004977">
        <property type="entry name" value="Ribosomal_eS25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12850">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03297">
        <property type="entry name" value="Ribosomal_S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN98984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="120" mass="13048" checksum="1F1C8955BE9C46CB" modified="2014-11-26" version="1">MPPKAGQTKKAKMEAANKGAKKTTKKWSKGQSREALQNAVMFDKETCDKLRSEVPKYKLITPSIISDRLKIAVSIAASGLKQLCREKLIRLVSCSSKTRVYTRIVQAAPAETAAAAPASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUR3</accession>
    <name>A0A088RUR3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_281100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700450.1">
        <property type="nucleotide sequence ID" value="XM_010702148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUR3"/>
    <dbReference type="GeneID" id="22576555"/>
    <dbReference type="KEGG" id="lpan:LPMP_281100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280016900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_281100"/>
    <dbReference type="eggNOG" id="ENOG502SH2X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267158at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="648"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="755"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="900" mass="95974" checksum="EBC6253B16A19588" modified="2014-11-26" version="1">MHQRVDYVPPALAVTGKGLLEGTLQSKFVDVAPTTTAASAHRGSAAAAAERRSPTRKQPLVAKKVTSRDPRSRQRGKWLGQESKGITTMATTVSSCHVAGHQNSLLSLPQSRETAVEVSLVQNLKKQIACLELQLRVMKQQQDAMARMHRDSSARHDAERAKTSRTTSAARLMSVELPLLHAERIRHADAAAVTVKTPQSDDDAIARMRGVPAAYQTERSILLHNLESLTKDVEGLQGLALHLGRERDLMATEVIDFRAALREMKIENEAMAAECAAMHQLLETEKALRRAAEESVSPSTKGASSHRNIMTAADALSQRAYYKLQAERTAEALTLTKAKVHTLSVALQRERDAAKILEAQLCGGLDRIALMERRESALALYYQQLSGRFVTISSMLRHVLDVVPNELLQHQRIPSPERVPASQSAADEMTMAELRETLDAWHSETTAVMANAQHTTETITGGALALFEATTVTTVSITSDGDDEPPFISEEAAVTVPPPRIEVAQQSEPLPPPLHNPFVDVGAAAQMAVVLQDAQRGDRQDTHNQGATVSVPMKSEELSVPTEPDSEMMPSPAAPQRALLAEKTSVVNPTAVYHAAEIYKSAELPVNEKSGAVHVVFAPAEPFEKKQTAEMTAESSLAAPVEKGITADIPVDAPSSSGDTYEVPPAAETPSGITPLSPVTPSLNAALAAHVISDNDPIPVLSSKVASLDGEDTPAFHPPHSLTFTATVVPEEESPAPTSEGGVASENGVLLQEPQSTEADKTPPAGNLEPPTTGEQVRRDAGTETAAAGEAVPAVEIAVPRVPLPLLSTVTPLQAPSPPRSTLPPSPLGVAISPPLHQAFLPVLLPPAVLPPPIAAIPTSVLPTPPVPPPLEQQLELLNVRIDTQEAALAEMVRRYGGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUU8</accession>
    <name>A0A088RUU8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_283100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700649.1">
        <property type="nucleotide sequence ID" value="XM_010702347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUU8"/>
    <dbReference type="GeneID" id="22576755"/>
    <dbReference type="KEGG" id="lpan:LPMP_283100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280038000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_283100"/>
    <dbReference type="eggNOG" id="ENOG502S0UV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270163at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053125">
        <property type="entry name" value="RNA-bd_mRNA_stabilization_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37035:SF2">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37035">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN99942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="332" mass="35597" checksum="25FE231D66555A86" modified="2014-11-26" version="1">MHRNRNRRKGPPEGRSVQNVLSTDGIPPGTFAVIDPLSKRLFIPLESMLDTRAMHRKGVPSLCRVFLEGRCRQGTNCFQAHANIDLVLELRAKALAVPTCCALHGSPSDMSGIDPTLRLVVRNDDGETVGLARLRQALVTNGLRTLIAAQVSAVGMPAPVDVVVSTAALCRSHSGADGSPCCRFEGECNFVHLCRHVVAQINQRREAVKAEEHLAAPVLAVGKHSETCQDEFMTVPDMASNRPTSSPLQLRSQPASTVMVPMSVSANLGVTPSIRFDPLALAVTAPSAMPDSGALLMGRSPLMSRSFSSTPSGLVWRHNPYNSSHASSVIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RV04</accession>
    <name>A0A088RV04_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_290420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIN99992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700935.1">
        <property type="nucleotide sequence ID" value="XM_010702633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RV04"/>
    <dbReference type="GeneID" id="22576806"/>
    <dbReference type="KEGG" id="lpan:LPMP_290420"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290009400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_290420"/>
    <dbReference type="eggNOG" id="ENOG502R8Z1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="564" mass="64772" checksum="C61B5CF0512A8655" modified="2014-11-26" version="1">MQLSQNVARTTVPSYYHIRTNLPQRKPQNQWEGVYYYSGITKRQQHVVLLQRKREREMYLRQYNQNVASLRRQYTKHQEKPLASLPERLTFASQLASCGMHNEAAALVDVMHGSKELRAMDYIHLIGSLRASDLGACILHSEAACDPALTFKLLGDNAGAERAAEAYRWYDMAMSALGHECGSFRLESTPTASQLTNALMRTLMTCGYAHVKAIPNAVYDRMGVRGISPTASTYDLVVLALALTGNVAEAEDVFRFVRSRHAEHVTIRGYNALLLGNREARLFDRCDGLWQELVDLRFPRASPLTAELYLRSVVDHAYTPTSEGLQRFGSVHAVEKKKVPIVLAQMDELGIPRMHLSGPLRDEVEDALRKFSIYRNRFYEWGRAVKQFDFIEFRRRHGWMYDLHLMKNTTKMLPPIRDPSQPDSTMASAAMVELPAFFTERHPWERDALESLLSVTKERERMDDVRAGDIYYDDTKSIHERSSTWMNEVPETRYDQLYGINHPDVSKIGIRAHLEVEYTNRKEVMERDAALVRKSIRRGRRLRHRVEVSRTHRNAGSLTAKAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RV93</accession>
    <name>A0A088RV93_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase, putative</fullName>
            <ecNumber evidence="3">2.4.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LDK</name>
        <name evidence="3" type="ORF">LPMP_282120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99845.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700552.1">
        <property type="nucleotide sequence ID" value="XM_010702250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RV93"/>
    <dbReference type="SMR" id="A0A088RV93"/>
    <dbReference type="GeneID" id="22576657"/>
    <dbReference type="KEGG" id="lpan:LPMP_282120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280027500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_282120"/>
    <dbReference type="eggNOG" id="KOG0588">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004645">
        <property type="term" value="F:1,4-alpha-oligoglucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99845.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="868" mass="95066" checksum="88A57B21709FCF8B" modified="2026-01-28" version="2">MATGKVVGDVVQYRLDTPIASGAFSTVWRCTELSSGQTYAMKIVEKRVAVRNKMTGALIREVNALEIGGSSPYVTGLVDKMVSKHNYYIVMDLAEGGTLLDMIRERRQELKQAQVSLPSGRSLLDSLQLSGTPFMPYDRVRHYFKQLLLALSTLHDRNVVHRDVKPENILLNKRRTRLVLSDFGFACHCMPGVKLHRACGTLKYCAPELLREYPSYDGRKIDVWAAGVTLYVMLFGGFPYRCSRGDPDSLLEVIETTTYRIPRPIPADIEDILQCMLCVDSDQRWSMKQLLNHPWMSGLELNSPPSRASAGEGLTSPTITMPNTAEAITEMLSEGCSPMDSFPFDEDDVDDGFYQSIHHEQLNSSVSSDCHNSTTPRQKPQQRPLHADSGASQGDVVSLSSPTSLLHSGESETRSASAAFALLTPPSQLLRTSTKQEILQHGTEFTSMASIESSVASDDEREEDEEEEDDSEDDTHHWDEMDEGAVATDHIRSASKGDNLSKDAPCASDAQLCELWGRYSYGLWLTARIAAHLVAFIAVCLVAVALRVLLKCDIIDLPLPEGMRDYISFVLSTPLRRPRAHLSDAALTLSQSPGGSSTASPLALLQKDSHGGSSAHCRLMAPPIPGSGLRHYVRRADKLMRDSFMGSVVLSHNIPLVDLAHRKMAAPYPQELSVDHSLSSTPAAPSLATMAPSQSSAVRQPRERDEAATTEARAESVERAVLSMPPRAEKSKRNANRPGPPASGDEGGGKEERDWQERDSSLRKKCRRTQSPGPPLVLVEDPISVTTEATTCLDTTANPKTSLRSEAHVDSQAGATDDTGSGDSALDKPAYLPHHNFMFSPISPMPMVPGDHQRGVEDFPIVTKMGHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVC4</accession>
    <name>A0A088RVC4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_260700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699891.1">
        <property type="nucleotide sequence ID" value="XM_010701589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVC4"/>
    <dbReference type="GeneID" id="22575973"/>
    <dbReference type="KEGG" id="lpan:LPMP_260700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260011800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_260700"/>
    <dbReference type="eggNOG" id="ENOG502S060">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273435at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="955"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1145" mass="122116" checksum="358919858100F5F3" modified="2014-11-26" version="1">MCSHPSCTHVLRAPLLSLPLSPELLETKEKNRGAQRGRGDSRCQHFTSLDLPPQTSKENTEGSSSLPAHVGMSYGDLWKTRYGASVEGWSAVDKVAQFSQAVGCVSGGRGSAILIALMDNRAQLIDTSSLERSGSADNNGTNPSYGLTPLHRSGGGFSAQRAQRRSSRGWGAGRPANGGVSDSPETLGQPGTSHSSTSPQSPPALGVLLTTSHVFRSPQDTANASVRFLDQPIIGMAALLGREPKPVRVGLCSAFGFVSSVAASRKESEGDTYRANAAATARPSRLDDEPEYLLYASAAGDSSEEDEAAEIGFTLTYCEVFPRCNDAANPTEPSSPLNPSESGGSRGCRTESTTISPSGGLSHYGGGTRLGKEVDEAPASLSESALTQQRGANAVISDASNAPGGPWSSRFASAAANRNVGGSQDSLFQVQPLPVPLLLAAIPAVKVRDVHLMITHVNDGRRSYRVQHVAAVFADYCTYEPTRFGGVTCSGGPVFNVQGDFIGVQHEGNGQSLCLLIKSIVRNLFDSDLLDMCRCPVSEETIKQRALHVRPGDTVFSTMTTTRPPVFAGPKRMPSLRKNSRPTSLPPLPALSLDSQSLASPRTESCFAVDTPSTTVPLPLATVSSFGNRHTLLHRPSNNIAESFRKDVRPASDGATVANTVSAAALPLTPPSKPLSRGVPSFEEVFAELYDGAGSLPHILYAFPRNLPLVRVTMERLAQLKYEDELEHMGAIGGVGAILEAIDGYPQEEQIVASALAALCRICLYECNLAMFLYLDGVVTVMEIMKEYVHKQTVLQWGIYTLLLATDLSCPSAAASAEIMARNSAPQLLVNILRVHGAVQRKSAARRPQHNRLVRWACDLIANLLMTNSRRTTLFLREDFLTLLLQLSRDYAGSVFLMEGFAHVFCAFVQCFTEAEVPALLPILRVSSASSFKQHPAMPSPGNSHASLFRGLGVRGRPSNSSSVAHGGGSDRFPHDNSGPLASPASATLLPYSPSTNATDPHTVSFFFLGDAMRHDTDGCLVRAVLDVCEAALDPKSTITAHRGRPAVVLVRCLETLRLLLTWGLVKLPGGGAMLAVEDLNFLALASSRAMPTTCASASSLPSLSSSEDTARLLLICKRVRHELTSSSELVAMVEAVQRLLLQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVI0</accession>
    <name>A0A088RVI0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_290830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700691.1">
        <property type="nucleotide sequence ID" value="XM_010702389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVI0"/>
    <dbReference type="GeneID" id="22576847"/>
    <dbReference type="KEGG" id="lpan:LPMP_290830"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290012500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_290830"/>
    <dbReference type="eggNOG" id="ENOG502RY9X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265338at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="406"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="481" mass="51326" checksum="EAA0833DB89285BC" modified="2014-11-26" version="1">MDSFDTGATLASSGSSVGAAYPAEAQFLKAAADGDTSDSSAGSPLAVGGPLQAGEGESSVADTCSTMGKEAGDDAVAGNNEGDAAADYAGAEDDKMYPEGDDGEEEDAEYVEEDAEYEEKEHSDEEAYEPEEAAADASVTPSSASPKPLIITVGTRQYKASAFVKNRGLSYVPGRLKSNPKATFEPCTTNAPHSILDCQKLHLNNRGVLVRDRFIRLNMLVDNPGKKTLLHNPGRSQKMRICRRNVEPEKSETHSPATCSDLHLLPDIVFVGIPGLRTAYFEAELRHNLAFTKLKEAPWETQCGTWCRSTRSHVVTTCRFLHYNRGDNYTEKPTPPHRPLAAIPDLTPSRPPQVTDLSRRGRGRGGRGGGRGRGNCRGRGRGGRGAAAIPLPAAFQPGYVAPSQDSSSPGSSITTGSSGAANRMKHSLDALEATGWMTNKGDDSRTINYWVLNVLFVLLGVFVFLLAVALRRVNEPAAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RW51</accession>
    <name>A0A088RW51_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribonuclease inhibitor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_292820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700886.1">
        <property type="nucleotide sequence ID" value="XM_010702584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RW51"/>
    <dbReference type="GeneID" id="22577045"/>
    <dbReference type="KEGG" id="lpan:LPMP_292820"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_030014900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_292820"/>
    <dbReference type="eggNOG" id="KOG4308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001081">
        <property type="entry name" value="Ribonuclease inhibitor-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001083">
        <property type="entry name" value="Ribonuclease inhibitor-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="565"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="653"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO00229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="735" mass="81187" checksum="D39863EA1A185D0C" modified="2014-11-26" version="1">MESAIFTPELAAAPCHANPAVTVTLPVVAATLGGQSLRPAQDDYEAQLYRFKSTKSRAFLQDRQEITTNLPHLLPDGISYAANFVSFDHLRECGALSEMRHNEASITADDLRLLYEARCLDQDLVPSWQREVRFMELISAKCKGNFFCLPENGLGVCCAEALAAALSCNRHYSVLDLSGNRLRDDGARFIAQLIKRNRTLVHIDVASNDIGHVGGVLLARALLENDTVISLDIGARAGTNGNHIGTPGAEAFGEVLRRNEVLARLNVSSNGLGAVGVAFIASALEHSRSLTCLNLSSNNLGFDGASVLASRLEVAHVTRWELPRNYLGDKGGACLLDALAGAIRNGHDVVEYLDLDDNTLGERSAEAVGKVLSASATLVTLRLNGNPLGAGVKAISTGLNENHSLKSLFLRKCSIDQIGAAALGATLYVNYTLGQLDLSNNRVKDGGAVELAKGLAVNKCLTMCNVSSNRIGHVGGLEMAKAMQKNRTLRHLNLRHNLMLEATGEAISDSFRINKTLERLDVSYNDFSYACAMSIERALERNKASNKTLLVPRLQANIDALAPKEKELNRAVEDIELEKRMVRDRGEELMRRGEEARVVAEKLRREITDLERVFEKASALSDAAENLFRLTEDRVTNNLTELKMKRTNIDTRIQQERDRTDRLNREIEKIRRQIKHLEEAENERLAPLLRELEETERDRTREMADAKFEGERLSALELRQKELQIAASRRSAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RW89</accession>
    <name>A0A088RW89_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_271540</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MICOS complex subunit Mic10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700241.1">
        <property type="nucleotide sequence ID" value="XM_010701939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RW89"/>
    <dbReference type="GeneID" id="22576332"/>
    <dbReference type="KEGG" id="lpan:LPMP_271540"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270022400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_271540"/>
    <dbReference type="eggNOG" id="ENOG502S5UG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1916310at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007512">
        <property type="entry name" value="Mic10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21304">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21304:SF4">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 21KDA SUBUNIT N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04418">
        <property type="entry name" value="DUF543"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN99534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="108" mass="11536" checksum="0045D43CD76AA8B2" modified="2014-11-26" version="1">MSALPKQASTPTSSISSDEKWDHSLETLIRKSTIGFATGILPGLLLARSPAARSAIVALCTGIGSGIAYGEARYLFDHDIMFDKRHLIQVQVVGSSSCQENGTQKSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RX17</accession>
    <name>A0A088RX17_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_310790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701468.1">
        <property type="nucleotide sequence ID" value="XM_010703166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RX17"/>
    <dbReference type="GeneID" id="22577505"/>
    <dbReference type="KEGG" id="lpan:LPMP_310790"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310013200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_310790"/>
    <dbReference type="eggNOG" id="ENOG502SMJM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265961at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="482"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="520"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="618"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="652" mass="72607" checksum="A873F419D4C00BAA" modified="2014-11-26" version="1">MPSREENEQRPLSRSSGLASNVPRDDSPWSQAAREPISMGEMPDGEGVAPRPEESLNDMDEEQKEEIRDLMLNVVMHADRPIENLPVMMAPELKLIGRCVSLRVMQAINGAPPAFYYYTGLVCMVTESSVSLMHVNRYTHDDFAAYKSREQQLLKGTTISPDLQIQNCCALRHSRVRACCLYSVLASPRADSGDASSTQRVQSLDWDLLNHSCTAAGEAGVTQNDRIVNTEDSHVLCTMDAAGSLAPAVLLKTGAELDAAAAQNSDEEGRMSGVTEPVVDEVTDSAGATKGDTAPRRFRAFVGSIGPIPYVTFLRKNINNVEFGRDPCSSFYSLFKDPSRHIRDMQVLRMFVRRYLVHTSQGNNPRQVLLYAFLSVRCAWPDVDRELVNRVALEELPTLLKADCAIEKEKKRRRLRMQQRVREVQQYRAPAGLFSNTGILYLTNIPQKLFLAGMLILLFDIGLIVFFNSAKSNVSDALVSSFVFQFTGELVAAIVVWSITGVMCIVHATMMHLPVREGMWYMGAHFACFVGAVACCIMAFVVLLMLLDRNTIFLHMVRNQPEELCPFYQRHGCSGFLVGCNDTESTFNRDLCSTCPDVNTSITGCYPIIRSQIGLTTIPLLVFSIFVTVAVLYSFFQLFKLLGIFKAAVDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXG1</accession>
    <name>A0A088RXG1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_312630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701648.1">
        <property type="nucleotide sequence ID" value="XM_010703346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXG1"/>
    <dbReference type="GeneID" id="22577689"/>
    <dbReference type="KEGG" id="lpan:LPMP_312630"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310034300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_312630"/>
    <dbReference type="eggNOG" id="ENOG502SY42">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="235" mass="25919" checksum="926B4FDA75BA4378" modified="2014-11-26" version="1">MLEQTAEAQMQRTGTKGAAVRVPSSQVFVKMPKEVRERSRSREALQAGNRSQKGALKEVNSRVFVRMPKYVRRRRSLSRESRSNGVRQLQERNDMPCATRNDMSVAAAKSTTEENAATPVQLHAEQEPYADDLTLQSAGEKRSHHKSLSESSPATVWATEADTVDKTDNAEGLACSVSKPTMQAEADSAVLAEEAKSNEEFKAEATSPTQKSNSPISMVENDNRTTEKPRCCTVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXK7</accession>
    <name>A0A088RXK7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_311290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701519.1">
        <property type="nucleotide sequence ID" value="XM_010703217.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22577555"/>
    <dbReference type="KEGG" id="lpan:LPMP_311290"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310014700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_311290"/>
    <dbReference type="eggNOG" id="ENOG502S647">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25503at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11709">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF40">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="174"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="253"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="462"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="626"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1038"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1124"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="517"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="739"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="817"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="470"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="483"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1067"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1135"/>
            <end position="1149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1463" mass="155738" checksum="EB0E3AE6E33D46BC" modified="2014-11-26" version="1">MSSVSAWSSEDAVGLPIPPPIPTPRATAASRSLRTQLCTSLSTTVARISPLSPSEVNTALAVAKMLVPGTISEVPVSSGDVPVATGIAASKPADSPALLSIPSQTERKHVPQQRLENGGKTRQDMSVVFDETAASADPTKACSRTKSTFTSLARLPESPGRTRSWRTLVLSPRRAANGATAAPSAVKDVSESDSGTPTTLSLDMGHRKTTKAAGAKPSTGATMLLSNDDKDAAAEVTITAAPEEAPRVDLYEGSGGLLTPRERCNTLPPPSSVSPLTTASTRTLSSDDDGEESSLVVSKRKAGNAHVTTEVGRSRRGTYAIQRTSAAPFRTVSGSVSDTVGCLRGRLAEASGLSALRSSTESLSALVSGDRVADAKSAEATASTELKELRQALKDKERDLVRLVRDLDKAKQAAAKAQRKSEELQAKWEGEKSAFADHKKGALTQRHELQKELRQAQTALRSAEQAQAKLQRELDKQKEKLATVSSRGASDTTTPVMTPRSTALSSAPFDNMLQAKVSSLESEKKLMRETIRQLEEQCSVAAAAASLAKTAEEHRSAAASKEAAETIATLKDEVLNLKQRLASQDAAVRDLRERADTLLEENEALKTCAKAERKPARSDVAVATLRSASTRGKGESEEPSLPMQPPRQVMALETPAEEAMAHLREALTAAQSQAGVYKCMHEHAKGRIRRLEAELAASRSAEASASPNVATVTLRDTMATLKEQLASRTAECGELRQCVQERTEEATTLQSALQEVEGERDAQLRQIRDLQFRIAEAEGKAATLLAVQKTERPAALEEARVELLSVRADLQVAAVSAQEHQEETNNLRSLLGDEQRRCAHLEEERRAAQEEAAAKSAAADASKQQADHYRKKARQLTKKLGEALRELSVLGEEYERVCEDRQMALSQPDTKNKMVAEARSMICGQPVAYVEADAATGDTEAAIQAVSPFQARRTTSVSRSLSDALLSANRQAAINGVTSTAWAIAALDQERQAREQLELDVLSLYSKVSAIEYLEQSSWNSAERGGACAATDASSADLTLGSSHGGQGHIQQPSRMPSALQPCPSTSGAPGRARSPGRARSPQATHALDPRYFDPTMFTCSEGQPRSAGVDSINLCGHAAGFSQQLSEPPQRGRSLSAQALQLSPSAGSRGDAQSPSRALSLRSMALVTSPTALQAYRSDSIAGPSAASSELPATSVYYSTGCSYGTDGGAGQRARVELQFSDTAGRLLRSMRGRRVQRPVFPAAENEAAQLDVCCTAIGSISHTIYASHMLAAGHYHLKHTFRFIIRVLNDCRSGGDILIGFSDRYVPMESFGAKRNALRYSGCYYLSLRDGCLFCPAQDVSGAAYEGWSAAAARAAERRCSIGVGPRQDGGALSISAQGIEAPLSEACATSSPARKRALLRPECVARAGDEIACTLRTDDRSISYSWNGVECGVAFTGVPLSPSLYPCVEINASGGAVELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZP2</accession>
    <name>A0A088RZP2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">inosine/xanthosine triphosphatase</fullName>
            <ecNumber evidence="9">3.6.1.73</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_311550</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ITP + H2O = IDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28330"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58280"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.73"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>XTP + H2O = XDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28406"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59884"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.73"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.6.1.73" evidence="9"/>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701545.1">
        <property type="nucleotide sequence ID" value="XM_010703243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZP2"/>
    <dbReference type="GeneID" id="22577581"/>
    <dbReference type="KEGG" id="lpan:LPMP_311550"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310021600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_311550"/>
    <dbReference type="eggNOG" id="ENOG502S3KM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="300709at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103023">
        <property type="term" value="F:ITPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.950.10:FF:000002">
        <property type="entry name" value="Inosine/xanthosine triphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00648">
        <property type="entry name" value="Non_canon_purine_NTPase_YjjX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002786">
        <property type="entry name" value="Non_canon_purine_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026533">
        <property type="entry name" value="NTPase/PRRC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050299">
        <property type="entry name" value="YjjX_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34699">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34699:SF2">
        <property type="entry name" value="NON-CANONICAL PURINE NTP PHOSPHATASE_PRRC1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01931">
        <property type="entry name" value="NTPase_I-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-canonical purine NTP phosphatase/PRRC1" evidence="12">
        <location>
            <begin position="7"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIO00745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="179" mass="19210" checksum="A1BC8847CF8084DC" modified="2014-11-26" version="1">MTVWAVGTTNRAKAESVMTVVNKCFPGEAHEVRLCNVSSGVRDQPMSAEETQRGALNRAKAALEIIPGADYGVGLEGGIEDIAGRWFECGWMAIVERKTGKCGIGSSARFEMSETIMRPILNEGKELAEVMDNLTGEQDVRSGLGAMGVLTAGHLGRAAAYEHGLVFALAPFLSDSKYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZT5</accession>
    <name>A0A088RZT5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_312180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701605.1">
        <property type="nucleotide sequence ID" value="XM_010703303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZT5"/>
    <dbReference type="GeneID" id="22577644"/>
    <dbReference type="KEGG" id="lpan:LPMP_312180"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310029000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_312180"/>
    <dbReference type="OrthoDB" id="265606at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="240" mass="25576" checksum="A5D6F697CF1ADC6F" modified="2014-11-26" version="1">MSSLGALSLVGTLLIVLLVIGTLVVVLHIAYRKDSVALEEEREPELRATAEASRTHHEPSFTQMPEAIPVERAASDNVPALGNVVIKDMNLLRSYEGELVRVDVHNSPPEALTNGAAPSDETGNQGRGLQGVGTMTGPSGQRPVSAESPPTLEDLQPTEEIAFPADLQHGGYVIVECPKGHEELAGEEDGTTAAVAPTQQLSNRRGKTPPPRLEFYRHRTSSALYGTAQYCHSPLSNSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZZ2</accession>
    <name>A0A088RZZ2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Electron transport chain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_332830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702374.1">
        <property type="nucleotide sequence ID" value="XM_010704072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZZ2"/>
    <dbReference type="GeneID" id="22578436"/>
    <dbReference type="KEGG" id="lpan:LPMP_332830"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330036200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_332830"/>
    <dbReference type="eggNOG" id="ENOG502S2PN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277888at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO01574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="165" mass="18805" checksum="D8A0C2CE263A8F85" modified="2014-11-26" version="1">MHRGGLQTSPLLLARGNTGPQVLGTEVPSFRNFPYRAQDTLYLYRHFLQLIYHHYAPEERKDLLFRLRNEFSSKRHLHGPRAISAALKRGEGMLALQRQLLQSREVRRGTSRDGGAQSVDALWDQLQIVSGHVLPGLRNYENSLPVSHGGYLTQASTSNVYSRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1M5</accession>
    <name>A0A088S1M5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine-threonine protein kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_040620</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="AIN95386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703708.1">
        <property type="nucleotide sequence ID" value="XM_010705406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1M5"/>
    <dbReference type="GeneID" id="22572021"/>
    <dbReference type="KEGG" id="lpan:LPMP_040620"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040014900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_040620"/>
    <dbReference type="eggNOG" id="KOG0611">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="172"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="415"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="640"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="911"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1033"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="911"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN95386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1243" mass="134590" checksum="1D2DA561A417C6DF" modified="2014-11-26" version="1">MYAPASAGNHTSRCSSRNSQAAPKRPRHEGVGWCRGRSGRDDSEGVQVWGVLVSQNPPSRENGLLTYAQRCRCSAAEADAPGKGSARESMNSSSLRDWGEDWLWRRVPPAMRKLYFPVCPNSENKYPCAPSSPEPSEMSATALLQHGGDKSHPLPRRLLLPLCGTRSNNCTVSLGRLASNDIGFITNPCVSSVHCTITYHPGSDRRRGAATAVAAAVAAEDEEALRATDEATIAVDRGVARLHRSPLSATEAPTSPHPRGGATARSAAAEKQQQPSVNAHVLLSDYSTNGCLVNGRMVGKGCSARLCDGDTVELINAGPQRTAGYNLSFVFLSADAWVRWVKEQQQQQQPPEVATTQGADEGTAMTARAARKEPQQHQALQMAARRRALLCRAQWNVEAQVRRMYNHSVDEYYSLDRTHPLGQGTFGAVYRATLRTSASASSQSASLLPTGGGIAAGGSPSWEYIFSSASVSEWPANPAEVARLRDAYIRGKEQQAPATVLRASASAALTATWKAEATTTDPVSQVFAVKIIRKRRMLVEALQQLRQPQPQRTKEGEGSASGAPVSCVQSTAIATTGSAGTVVGTISSAEAAVIEQLLLLETQPDDLAAQRREEWTAGALASLQLADSMPAPLTPFSSLSAWRKSKHTSRNDGASDDRGDAQPSPQQHDREQRRRELIRCLPVALRRTYERELQHRRRQQCEINVLLAVRHLNVTALYEAFDQPDHLALVMEQATGGEVWDLLQTYKRRERREQAGARMSDSATCGDFDHDDDLVSVGGPLPEFMVKTIIAQVIEAVLYLHTMGIIHRDLKLENLMLHRPCDRYALNALQLQMLIHQLRAYAHQRHASDASTSPTCAPHACKENSEAVEFTNPLSVLHTVHIPRHLWPVVKVMDFGLSRVLDHLQTQLFEPTGTPHGFTGTTSQTPPDAEGRSAAVTVATTEAVPERVKLIYSRNDATTSCGTPIYAAPEVTNPALRPDKVGYSAAVDMYSVGVIAYALLTGRAPFPSKKHPRRPDGPPVVDYDAPLCFERRRRRPAVPQDDAGSPGSAASMPLRRLSSSAARPPVAVACLPPLSVIESVRVVLQERAETSAAPSTASAKAQQWHRHAEAVAAYLYRAEQTDAHAESSAGRSSAASADTFFDVTVEQLCASLTTYADMCASGGLEVDLDRLLYVSADAAATGVEAANASVGHVVSTDGHITEVSLPPVSALGSSFLRGLLEKYPSRRLTAYEALQHPWLRECV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1Y4</accession>
    <name>A0A088S1Y4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Centrosomal protein POC5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Protein of centriole 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_352760</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Essential for the assembly of the distal half of centrioles, required for centriole elongation. Acts as a negative regulator of centriole elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the POC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703213.1">
        <property type="nucleotide sequence ID" value="XM_010704911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1Y4"/>
    <dbReference type="GeneID" id="22579305"/>
    <dbReference type="KEGG" id="lpan:LPMP_352760"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350035000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_352760"/>
    <dbReference type="eggNOG" id="ENOG502SATG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10064898at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033351">
        <property type="entry name" value="POC5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28618">
        <property type="entry name" value="CENTROSOMAL PROTEIN POC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28618:SF1">
        <property type="entry name" value="CENTROSOMAL PROTEIN POC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="40"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIO02413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="339" mass="38904" checksum="1F1B4FFD976B6211" modified="2014-11-26" version="1">MPLVKAETDERFVAEVAQSVDGACARMNDHVSGMIEEYLRRRIQQVHDDAKQELDVVRKQLERRIADAEAAKAAEEERHQKTKTQVAQAAVALQQMQARLHLKPLFHTWRRCADVHRERRRLAVEAHIHIGRLGMFHAYTQWRLFAAACRQNRLEAKEMHKRDCREQELLGQIEEYQRQLEVEREKDSRLSEKLKEAFVRGMCALNREAVHVLHGSEENQDEDVEAIAEILSRESNSRHRSVAPVHMDSSIPSNTHAHDVCPVHHVDARGNFYHPCFALGYCEYDRRQASRSPVSSGAPPSASGPFVVCADLQTARSIDSGPLVPFRRLSKSSKTRWRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2D3</accession>
    <name>A0A088S2D3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Beta-fructofuranosidase-like protein, putative</fullName>
            <ecNumber evidence="8">3.2.1.26</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_340580</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.26" evidence="8"/>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702485.1">
        <property type="nucleotide sequence ID" value="XM_010704183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2D3"/>
    <dbReference type="GeneID" id="22578562"/>
    <dbReference type="KEGG" id="lpan:LPMP_340580"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340011200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_340580"/>
    <dbReference type="eggNOG" id="KOG0228">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3770">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="202537at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004564">
        <property type="term" value="F:beta-fructofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18624">
        <property type="entry name" value="GH32_Fruct1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050551">
        <property type="entry name" value="Fructan_Metab_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31953">
        <property type="entry name" value="BETA-FRUCTOFURANOSIDASE, INSOLUBLE ISOENZYME CWINV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="5">
        <location>
            <begin position="38"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="6">
        <location>
            <begin position="475"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 C-terminal" evidence="7">
        <location>
            <begin position="839"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="440"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="440"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO01685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1090" mass="120896" checksum="186E020744BB2972" modified="2014-11-26" version="1">MPRQHCRHVGGTVSAAARALAVAVVVLALYAGAAAAIKVNLVSDVHYDPAYATADAYGACTTISALPFGQVGCDSPKSLLAIITNDIMIQRSAYTFFAGDWQRHGMTSTSLTMTDVFTPLSNYFARIVDSCIDTDFNTPRVTTVLGNNDAIPNYFFNITATPQTTLDTQVDVMKEYALLTETQGTVMSKCGYYSGIASAQLRVLALHTLVWTYKLSPALPDTETDPCGQLGWMESEINAARAAGQKVIIIGHIPPQPDVFRVISRGAVGPVEDDMYWKPMYQNAYTTLLSNNKDIIVLQLFGHTHRFAILGDAEMGVPLVVINAITPLYGNVPAYLTGDFDMATWKLKTLRQRYAQTVFIQWNDGLEVGAALGITDLTNVSSINAAVAKMFANDTLFTNYMTLRTGGTISDPCTTTFCRVYTVCAMLYATHDNLARCVRSQTPSSSSSEPTDSRDSTPTPTPDSSIHVDAQPQYHLRPWKNWISNPNGPYRDPVTGKIHLYMQYNPNGPLWGDIAWYHVTSEDYVKWTRPVSPVAMWADRWYDRWGAYSGTMMNNNYGEPVIMYTCTEPENIQRQCIATIPSSDLAGKRTLNTFEKSPLNPLVTEESVPGLVGLENFRDPTEWWQDPANPDQWLIAFVARIADSDGDNAHVILFSTTDPTFQSGYSFSHSLYVYKYSTDKMLESPDFFTLHEGGEHYLKVSNIRSHRDYIVYGSYQADPSTGKYIFTEDSERSFTFIDYGPFYASKTFYDPILNRRMIWGWTSDELSSQQITSKGWSGVQNLVRGMEYDSVEKKLKTYPIPELKGLRLDHLYSRAETDPLVLVDGMPQTLIPAGINITRQHEIIVTFKLSSMEPFNGATYYTDSTAPEFGVMIRANANLSQHTTVSVRMPEATQQPIANRAQDMTWTPIKVYAGASTNAAGNCSAECAKDRTCVSWTYTTSPSPTCALYWKTSQRVYNTTAQSGTVNIPMLYMDRTHSGSIGSSQPILGRSPVKQTNPNVVRLHIFVDDSVIEVFKDGGLETMTGSLYLPRDESQTGIAVYTKNMGSVTVTASAEIFSLGSAFTADTDPKLIRSYTNSYYNLLSAMGVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2H6</accession>
    <name>A0A088S2H6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">DNA topoisomerase</fullName>
            <ecNumber evidence="4 12">5.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LPMP_353270</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="4 12"/>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703264.1">
        <property type="nucleotide sequence ID" value="XM_010704962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2H6"/>
    <dbReference type="GeneID" id="22579356"/>
    <dbReference type="KEGG" id="lpan:LPMP_353270"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350040500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_353270"/>
    <dbReference type="eggNOG" id="KOG1956">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="430051at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.290.10:FF:000003">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.140:FF:000003">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="entry name" value="Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="entry name" value="Topoisomerase I, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="entry name" value="Topoisomerase I, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390:SF21">
        <property type="entry name" value="DNA TOPOISOMERASE 3-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PROKARYOTIC DNA TOPOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06839">
        <property type="entry name" value="Zn_ribbon_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="Prokaryotic type I DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPO_IA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52039">
        <property type="entry name" value="TOPO_IA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 12 17" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0799">Topoisomerase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="14">
        <location>
            <begin position="3"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IA-type catalytic" evidence="16">
        <location>
            <begin position="161"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="GRF-type" evidence="15">
        <location>
            <begin position="915"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="876"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="887"/>
            <end position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS52039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AIO02464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="951" mass="104511" checksum="BF878FEF56D0CDF5" modified="2014-11-26" version="1">MPTWLNVAEKPSVAKEMAQSLSGGHCRTVQSQSRFNPVFEFNFEGKTMLVTSVVGHLMEDQFPPNTKNWSTYPFQGLFSAPISKYVRTDLEPVKKNLEALATRADALILWLDCDREGENICFEVMQVVQSKRPQLQVKRAHFSALTARDLLNAVHNLKLPDKRLSDAVEARQEMDLRIGATFTRYQTVKFRHLFAEVPGVLSFGPCQFPTLGFVVRRYWKQQGFVPEDFFTLQVQHGDTKFYSSRGSLYDQVAATLIYEDMLQAAAAEEHKGHITNVQQRPSRRRPPVPLATVIMQKLAATHLRISSERCMTLAESLYQEGLISYPRTETDSYTFQESELLELIRLQIANPDVAEYATAMLADIAARVRPPLRGGHDDKAHPPIHPTKAWNATRDERGSLYNLIVRHFLASLSPDAVAATTRVSAEFGGESFSTGGTTIVQRGWLDIFPYERWDSTCIPNYQIGDTFEPTTVLLKKGRTSAPPHLTESRLISLMDSNGIGTDATIAQHIKTVLDREYVRREGQSLVPTTLGIALASAYESLGLASLLQPQLRAQMELAMGDIANGAATKAQVVAAAVQLYEEIFSRLMASTGAFYEELKRHLRLAAETDAHAVQVTVVKDNFIQCGTCGRHMDLVERAGERDHDREVWSVRCRGCNKMHRLPNGRLNTLEPVNPPHTCPLCGFVALRVTNREKQTSYHVCPHCFGSPPRAWNVTGCGTAGADALLPDIEAAAEFRCFQCTADCPLAKGLEAIGITTCIACHQHELRLRSGPNGFFLSCRGYPSCHLSVSLPAAASVKPSPSQRCPACNAVLLTFDFSGRQGVPGLNMLDTICIRCDARIKDYITVKGFLTGGASSSAMPSSAASVASTVTGTYTLPSVTSSSRRSGRGGGQRGGRSGGAAAGEANMSTGRVDTVCGCGMPVKQLVSRKEASRGKRFLTCASRKCAFFQWLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2I8</accession>
    <name>A0A088S2I8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_060870</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703968.1">
        <property type="nucleotide sequence ID" value="XM_010705666.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22572293"/>
    <dbReference type="KEGG" id="lpan:LPMP_060870"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060014800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_060870"/>
    <dbReference type="eggNOG" id="ENOG502SHBK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF565">
        <property type="entry name" value="AT28366P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="7">
        <location>
            <begin position="1447"/>
            <end position="2121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="26"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="710"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="782"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="827"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1409"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1503"/>
            <end position="1523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1624"/>
            <end position="1672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1829"/>
            <end position="1918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="93"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="827"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1419"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1503"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1652"/>
            <end position="1665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1829"/>
            <end position="1838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1849"/>
            <end position="1878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1880"/>
            <end position="1891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN95646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2122" mass="219377" checksum="23A1948C14D77A58" modified="2014-11-26" version="1">MDQPRMSSTSLLVASPVMCTATRVVSSSTADREEVTLASVASGTSAPGATRSSTSLPTRFVSEARGSSPTPSTQLLAGTSSLSRDSTWATPAPNSNHSNRDSSSSSRGCRPLSPPLVQTTPVSTTATTTATLQVTHSQQVWRAGCEMATITSYTGDGVRSVAGPCQEAEACRGCSTIYRCSEPSASSSSSFVSAAATTKARARRSERRPSCVVQAELMDSASPGEVRSRHCVNAAAAAVPVTVRGFASNSIDVPADLTGAPLSDELVPVGAPVRERSDLHAVSRVAEVDSIAVTRTATSPTSSSPLTLSAPFQLRDTGTSDVPCWQMSPGEDGSCPEGAEYINLLELLTRASSTHEGLDAASTDEVVPPLPGMDTVAHVEEPAACSPSPDVPLDNALSAIHIPKVGSVSRSDTVERADVNNLEFGEHKQAPVFRSLSLSHGLIDDDAAPHTGRAKEWQSAVASSRSQHNIAAALASSGRTVQETGSNSSDGPSVMLLHNLVAPRLSPWGTQLESRGDMDNDASAESARPTPLLALSEAHHNGSGVFAGRQLRAGPSGTAATTFTDVAAPASTAAVVPATARSQSTTSSTPLLDSFRIVLSPCPSSIAPSFSLVPCPSTSRVSSPVSISARVVQQRWRGQVRACPGVGAGDACGTSPLPVAAHSLELAGGRALGSWLPPPLAHAAETSRSGRVAGDGAWGAVRVTPLQDWERSPWRSSGDGNAADEVTEPMPLHPTCWGTTANLSEGVSGLRRGCVSPSTHDAPVYNGPRSSCNHAATLSLRSGLPQPRLASLDATPPPEPRPQQLPDCACNSLALANAATEGLSRVSPAAHALSSPSLPRQAEPLPLLRPDHGQRDGSCSNGAAPWTRDLLSPPAPHITAFAPPTALQPSGGSVGPGIPAAAAIAGRCGDTCNLPLLTTAATTSVLGTSASASPLTTRWSEFYTRAEHVGCTHLGQAESGDAYRATSWSPTPVMTAYRYDSSFRLSPTDASSYSSSAWRLPAQPAHFATTASSLLQIGSFTDIACRCVADEATLTTDTSLAGADGEDFVSTCSTPPPRASLSLLSQRVPGCTSSGRKEDVCLWHATATSARMLTRTSSSRPRGSPLAGAMKASTESLWSPSLCTSPTAVTAVGDLGSKGGVGHTCNRGRGPCCSDAVYAVPADSDGLVHFGVESELCGLQRDVNAKLPFSGSLSSALLTSTGVALEVHQQASPTTPCVDSERGGADCNDVGSSSVYVPSALLLVPPPPLVALPAHWCSFSISSPRGGDWTTPTVAIRTADTTATTSAFYASSPRRPSPVPSIPEQGALLAASMAMSESLVEGGGVAAALAKGDDEAEMFATLDAPTDVTIVSAEGVSSLLPTSSSAVSPATQFQCAFSSLRGCRNRQEDSVMLVANLPVRMRSSAIAVPSTEAAHTAPASAREGSGASARSSTGAVGEHTQWAEDDSIAATAVTQHISSEQDEVVFACFGVFDGHCGDAVASLASQFFPEHFEHAVKSYQRQWEQDQRDSRGASRGAGSSAQLGKEVLGSCDCRPEGPVAEELRGHREAAPMEAVKFQRIVSAALVQALVHLDLTLYNVLHRDAHGPSVQRRDAGSTASVAVFFKLPTAAASCHSDTREVAGSWANGTSLLPTGNGDAPSDSDGSAATRPPGRQEEPWKQGEHCEAPTSPMPAAQAGDTYRLCIANLGDSRAIVGNLQTGEVVLRTTDHRISTYPSEAARIRAAGGVVELDRIDGSLDVTRGLGDYRYKVEPEQWWDSTAATAESSATGMPASASSALLAVSAAAAAVTSLSSHAEVVAGSLPPANTPRRSDAFEDALVMRELRWPSSSSTTLRSLMSDDVDGGGATLGDSQRASNVGCTDGEAQSVSAPLSQESPPSDSAERMGDAHTIQEEGSQQILAPSSLPPLSPSSPLSSRPTYASTSAVALTSNAVSNIADVYEWEVHRGEVLIIGSDGVWDRMTSEDALSFVRRELLTAEQQSKAAAGNLIHSNDTPVEASNGVRMRAWKSPGLDRAGPEVSGATGAPLVFFSETLEGTPPRQQSPCHQQRRTSACCYPAGLLCSPDGSGAASYDQDDAANLLASTAGSAPCLFAVQAAARRLTEHVVNNLFGSDNTSVVVVAFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3H6</accession>
    <name>A0A088S3H6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_091260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN96041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704363.1">
        <property type="nucleotide sequence ID" value="XM_010706061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3H6"/>
    <dbReference type="GeneID" id="22572696"/>
    <dbReference type="KEGG" id="lpan:LPMP_091260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090018100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_091260"/>
    <dbReference type="eggNOG" id="ENOG502QU8D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000084">
        <property type="entry name" value="Bromodomain_-__putative"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051831">
        <property type="entry name" value="Bromodomain_contain_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22881:SF27">
        <property type="entry name" value="BROMODOMAIN CONTAINING 7_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22881">
        <property type="entry name" value="BROMODOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="178"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="128"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="301"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="601"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN96041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="656" mass="71021" checksum="0349543EE701E775" modified="2014-11-26" version="1">MAATPKFYNEEDVAALVRSLDRAEDHHIFAVDVLKTYPYLAESYTKVCPRRCDLATAAQKALEGAYSHDVRLEGLKADIALMASNCVAYNGPTSEYAETAAKFERYALGQIDHFIVEHNGGRRVSRLRLPSASSSQAHASPEDTVPQKRSTGMSAASTTPTPAVPSTREMVQLVDLLNRREDGGAFSVDVAEAYPDLRESYRKTCPHPMNLSLMHQRAKEGYYTTGSATVYSDTVAASFTRLREDIELLVRNCITFNAKVESWVTLARSFQVFAHRRVDDFVLRHAPSLRGTTMGAEVCKSEGTVSTSAPSPEASGVAGGNDVSRVRQTNPAAAADTVTTTSGSIGGNVAAAGSRKREHADERVIASDGQSRPPIPVPRVQVVAETTPHVCPTPLQPSLAIPPLLRRRLTLDHVRHTRLPLRRVGVSVSRDELYPPAISLTDVEASHNPSGAAGGAEAATASASMVNIDASCSAGHVLQLLRESVVKFFAAQRSGTDFIDAFAYSVREEQLYLSVLAVVAEKYQSTAAHLLLYETESAELQEWIALRALDCCRDPNWTSPSIVGPGGSIADDLHYLYFVRFLVQWPQLASLCCTTVAPSSAPSSAPVGAAARRGTSGAAPGSLRISRDQLKVVAQVTHITQEFLQFLEAMEERQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S4C3</accession>
    <name>A0A088S4C3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_111270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696974.1">
        <property type="nucleotide sequence ID" value="XM_010698672.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22572992"/>
    <dbReference type="KEGG" id="lpan:LPMP_111270"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_110017100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_111270"/>
    <dbReference type="eggNOG" id="ENOG502RZYF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273506at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14874">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="669"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1509"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1798" mass="191310" checksum="D7648A28D01A2B4B" modified="2014-11-26" version="1">MATRSTAEGLSDSAEAGAMDAAASSSDEVPSEKHFRPIVFLLNSHTPNNLDAPTVAHLLQPRFRKGDYYVVDLSTLANPMETPNEAKKTSATDAALHSGASPPQDRISALVQSALAKIAATRREAEQAALQAKVTQLSALQADYIEDGLSAEEALAVAQADLQDGFDSEDDDDASVESSDSHFRSGGRLPPAVCVVNVPLSSTAVARLAENVDSLAAVVLLESQCSVRELVSASATGRHNSSSVSTGTNAPNDRVKGRGPRTGAAVSSLSSAGKQQNLSATPGGSAEDVLGALGRAALAQPHGSAFQDVLLQHVSYPTEGANGAGASPQSPAVFRPSVPAAQFLSTLEALLLRIFSSWVRYDAWRAKRFLVPVPDYTPLLDSEAALSAVIVEDSMPAAAAAEQRPSRGKNTSPGGREGSIPLSTSAEPPTTAPHPCTMAQVAAEQFEYRAYMQRWIGSVSHRSTDSALAAGEAVQACLQGCMCQVTSSHGSSTLRTSADTSAAQLGEDTADAWAKCRVAVAVSSGASLRPPKDSITVGYRDKGAAICGATPICALAAPAIPADSVEEALAHTVTAEVGSAVLPSVSTALVTTSGDGDALHWMYDALVARDQHGWHTALRTWERTALYCLHRHPGTSGAPRTQHNAHLLDCPTTFPRFFREEDFLASEGRHYAPSSLSDDTEEDEESDSSSEETASDSSRGESNSAAEDAATELEPPVSREPPPPRPTVDHVGIVGQHLRRRRVLEQVRLSHARPPVQELLGCAAPCRAVVTETQWMRAVDGTVVEVARTAANSAQVRCAIIDARIHLQAGFMLECPSLAHDGTTKVTATDSRGNTPLPEPLVASAVLGFLSVGHQLRVMTEVVADNTQAFAQAAYTAVVAAAKDAALAQYEAQFRRVGKAPKSRDKATPATQLTLEQITETLLAALPPPPPSPHPQDGDRESAAVRTIMRVHVCFPLHDCVMTTTVSKAGVPGVYFRCLTPSQHSVHLTRRRLLFVHMWNNDRLSATALTHLQGIRVYLDGVVEVHSPDLACGVRLLLYTDGTYLTVSGECRLLVFPDGRFILYEGSESGRVVHRLQRGRVTTVTAPAVTAIAREDGVQLEMVEHDGTDDVEQASSTPSSRGRVCCVRFGEGVSVEQGEKGDKWSWRFAGVPTVFCDATAHEIAVAIDENECSRFAYLPRTNSFSLFVRDGGAEGMRVAADVAMNSGSIVVLPQGYDLPTEHEEQSSRTGVFAVDCAYGGVYGRVGTDHVYRVSPFGRCYEEVESGGAPQNRQLVLPQHYRRSKKMAEAVVVPEYASPSFRRIVTGEDDKLATVPTVEHAVPLHLQVAPLLPLREPSRMSASTAASPYSGLALSHPAVHAPLQVRCIALQENGTQFVVLDAASWMEWTSWWQQHSSNWVPHYSSTLSKGAPREGAPEERAFRLIGASRAGQNFAPLTAAGAENAPAETSVVQDCVLLLPSREASSAPAWCSAGSLTPTSVVWGTAAADDEEDNTAAKVAVTQTAEPLDAAPLSSTVTQGDEQAPLARPTDPHRVSRLPATSDRRGGSLNYWSSALCPQVVQFSLNNSTTEDVSIIPTVRAHTASPSADAATSSAAVASSPTIPVAAPKKTFSSPPSRAPLMRSYYPAVGELTGTNASSRFHTPLLEAQPRQVNFGKVLPERRYLATVRLTNISTVPCRYRVRVGAVMRPFLSVSYPHQFVAPGITTEVQVELCSGQPYGVVDSQLSVVHEGGAIEINVRWCTTDEAHTAQLGDGIMCVGWAYHKPVVQHPRMPAHNAGQPNEASTLSVSDVALDMCTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S4E2</accession>
    <name>A0A088S4E2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_353580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703295.1">
        <property type="nucleotide sequence ID" value="XM_010704993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S4E2"/>
    <dbReference type="GeneID" id="22579387"/>
    <dbReference type="KEGG" id="lpan:LPMP_353580"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350043700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_353580"/>
    <dbReference type="eggNOG" id="ENOG502S5V3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="248429at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="815" mass="88381" checksum="058121EB5E9083E7" modified="2014-11-26" version="1">MADPFIETGNPLELEVTRLTQENRELRQENTRLRARISLTATPSATPSNALSERASVRSVVDAIAAPVGASLGAKSTDKPGHALSHSSTRAETKSTQKQHQQQAVSTARIEEAVQRVKKELHGEVEKYQKVAEVKASQMEQLKQQFELFVTATCEREAAYELVYMQVFRDLEEQRSLVRAAQAQLEVQRLEAVKMHTSLQAAVAPSKHGTLASSSPNPPPKTEDVAVASSFSAVRPAKRTRTGKIATHIDDSNKSNATESHVTQEDVVEVQQEVTASEPKATPEPRQLRIVLGGAALRADSKSTQLKRPRANSAVSVPSATRSARARQSAAFTQLHIPVAPVFAAASVGTASGAVKPAETSSLETAAAASPAAASASSPAQQTAGNALGDLWALLARHTEATHGFLPLWQHLAHLRGPDRLAALRVMISLLLQLLGPADAALPLVLPASLSISAGAPPTSITVLATAIRLLEVQLESEMQQQRGAVVSRTDATAQQCSTLFRSLFYRLCVATLRRWQTAEAEVDAVDNWATVLVHLYGFQPALSKLAQYTNSTIAYERPRLAHGWITYTAQAIFAQCFTSSPTSSAEVAVGRWRELCESIGWSPHSLPLEKLETAAARCVARTRVGLGSFTAVCAEEALLSLRLVVLYRGFDHMKRIATLLELPGVLPMAITKEIYAELVSLAVMDRAPFHTADALQHALRLLREYVQEVSPERCTSAEHFVSVPRLSHLLATLALLRVESTDTTVTARGTETDSLIGKAVQESRQTALRWLHAQKVALNMVCQSTTFAHDRQLLLRDTVLGQRLLSDACTTVHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S4N0</accession>
    <name>A0A088S4N0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA-editing substrate-binding complex 6 protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_354740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703405.1">
        <property type="nucleotide sequence ID" value="XM_010705103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S4N0"/>
    <dbReference type="GeneID" id="22579502"/>
    <dbReference type="KEGG" id="lpan:LPMP_354740"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350055600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_354740"/>
    <dbReference type="eggNOG" id="ENOG502RCY4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2019031at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="CDD" id="cd23735">
        <property type="entry name" value="RESC6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058917">
        <property type="entry name" value="RESC6_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26188">
        <property type="entry name" value="RESC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA-editing substrate-binding complex 6 protein" evidence="2">
        <location>
            <begin position="1052"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1208"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1210"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1224"/>
            <end position="1240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO02605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1240" mass="134534" checksum="F9AACC9ED8DB9793" modified="2014-11-26" version="1">MLLCAARRCARSYPRNAAAQVTRIGSATQQRPRMTAFIIPACSACCYATKPTGTDSHVGESLDSVPDLKAGCNPVSSKAKGSRFVRSVDNAVALGKPIADLESSATPPSDAGVTWTALQVRLSPPPDLISATSITAYLKRLQSLLRHGGHLSIRACAVHELGKIVLPSVKGIDGATVLLLLQTLRMADAARTMPLVQDATTWISLHGPQFAPPQATAAIELLLHFDHSVACELAVALTQRTLPSTLFSFSTARALPILTALLPTLTYGQNSNLARQTIAQLEQASQKNIIAAEGLRDACIAGEFLSVSPGSLVQLLRALLTFKRANQALYSTEAASEWRSLEESVCHILATPEKCAEVPPTDVVTLLADLSRWREQYNRWGVAESTVNDAQGQLFTALLLRLEAITEHLRSFSPELTSSGSILPDPWVISDLSVVWSQCLACAETRGPSSDGLSSADKDEGANAAGAFVTALHALQSALLGVVSACCRAESQNAATLQMAVFMCSELVVSWMTDVHGERDEDVSHASSDDTSASLPDLSSLVPEAMLQVLIQGISAQLRAESITWTPSTVREAVISLGNSRDAAHRTQALELARRWYRQLQARAQGGERLQPIELLGFFVPPLLREEQKGVTEAVKASLPRWSVAEVLYFFSEVALHGGRAGGVESMAVLRDSGKLLCAYAAKASASQLVGLVECYGAAQVRSDDFCEAVATRVSELLRTTVADASREKTYTTVESLLTASDSQANSLAAGENRVSETDAAETSSANPGAANFFGMTIAHLARLLRSLALMETRQMRPFIDAVQSITRAADADQGTAEQITQLIAAYAKMLIWSYPVLRALAERLLRMNKSEVTLSHIVTAQLALLRMDVTLPSITGRFYEQLSQVYKPAADQSRVHSAPHTTLHDMVVQLSILARLRGHPSETPLDDAVVEVLIERIVAHADRLKMNEVAEVLLSLSRLDKGKSPAFEALNVRTLGMLPKAPSRVMAHVVEAYALAGRSEDTELFTLVADRTIAMRHEMASVTIASVLASFAKAGVRNDRLFIEVIPRVRHVATYGTPRDVVNVVSAYAAVNLWHYKLFSRLADRAIQLRADFRTPEMVALLKAYATVQMRYDRLFLEFAPRVQTLVHLLSPGDLVHIMSSYARLDIRCPPVWKATATQAITIAHHFTPEEARTLLEAYASQSFFNRECIDVLTRRFPELASISWDSAEATSEHNGITSSDADQSKSESSNKSETAQHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S4X8</accession>
    <name>A0A088S4X8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ran-binding protein 1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_131340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697214.1">
        <property type="nucleotide sequence ID" value="XM_010698912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S4X8"/>
    <dbReference type="GeneID" id="22573244"/>
    <dbReference type="KEGG" id="lpan:LPMP_131340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130018100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_131340"/>
    <dbReference type="eggNOG" id="KOG0864">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2357150at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00835">
        <property type="entry name" value="RanBD_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000488">
        <property type="entry name" value="Ran-binding protein 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF87">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE RANBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="1">
        <location>
            <begin position="7"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="158" mass="17818" checksum="415881DBA5AA50A0" modified="2014-11-26" version="1">MSKTDENGNELMEIEEVAVSDGGAARFAAVEVKSGEERFNVIWQDTGKLMRFDEGENQWKERGQGTAKVLQRKDNTSKYMFVFRREGIGKLAAQHYLVKGMKVTKHKQGEKILVWSAFKDFTDDEEGFPENFVMRLSSKEAADKALAEMAAAIEKSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S505</accession>
    <name>A0A088S505_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_140030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697239.1">
        <property type="nucleotide sequence ID" value="XM_010698937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S505"/>
    <dbReference type="GeneID" id="22573270"/>
    <dbReference type="KEGG" id="lpan:LPMP_140030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140005100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_140030"/>
    <dbReference type="eggNOG" id="ENOG502SGBJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277699at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="28914" checksum="46BD1B16DB33991F" modified="2014-11-26" version="1">MVVWGPLQRQLMAYIARHPQFQQAVRNTGQRVVAHPMFQKAKESAYSAFDKVGAKASGSTEESTFNAWRRRINNSWHKRKAGVMSFITANLMAILIFAQVSPMLWHSVRRGIHYLTEETPSAEAERKEKRRKEKEAAVEQSLFNAKAPNDTMRDNIPRSVPPHHAVQGSLTEHGTAASRPAQSWQTSSSLFDDTVSIKQQPDAQQSFNDMHKDVFRTSDGSAQINFETSFLVKMGDETSFTSSLEREALTGSASSCPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S5C5</accession>
    <name>A0A088S5C5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquinone biosynthesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_141030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Membrane-associated protein that warps the membrane surface to access and bind aromatic isoprenes with high specificity, including ubiquinone (CoQ) isoprene intermediates and presents them directly to Coq7, therefore facilitating the Coq7-mediated hydroxylase step. Participates in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the COQ9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697334.1">
        <property type="nucleotide sequence ID" value="XM_010699032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S5C5"/>
    <dbReference type="GeneID" id="22573370"/>
    <dbReference type="KEGG" id="lpan:LPMP_141030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_141030"/>
    <dbReference type="eggNOG" id="ENOG502S25B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="619536at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012762">
        <property type="entry name" value="Ubiq_biosynth_COQ9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21427">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21427:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="269" mass="29517" checksum="28FB8FAD7C288D45" modified="2014-11-26" version="1">MCAALSPTHFELRTKILSEATKHVRTTGFTNATLAASLKSIGGEVGDRALSHIFNRGFPIALVEHIVKSSNSCVQHELETAFNKEAIIKSIDSNLDAFVENRLLLPTEKNIAERAILSKVEFLLPLAQHWPSAVALEYLPSNLPYTVINLAEFVDTTVYYMERTATLGELLEPARRILQSKAMASHLQYGERGMNGASSASSFLRNFLHGIALSSGPYADHSTLNLRWYYKRAQVGLLYGVATTSLLGDVSRNAADTRSLTKAVVGAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S6B5</accession>
    <name>A0A088S6B5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_170630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97101.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697754.1">
        <property type="nucleotide sequence ID" value="XM_010699452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S6B5"/>
    <dbReference type="GeneID" id="22573806"/>
    <dbReference type="KEGG" id="lpan:LPMP_170630"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170012000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_170630"/>
    <dbReference type="eggNOG" id="ENOG502SKFD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10484706at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97101.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="361" mass="39206" checksum="6497AAE4F39F46B7" modified="2026-01-28" version="2">MEFKTTTSENDEGKIPAVASMDAFSQVETEYGSALSDFSCFEKEVITPVKLCTGKGVLDVFGVCFDDDTALLEDYHTERKDTCQKWESWQPTKDGGTFRGQRQFTCTTLVRAMMGKPYAYVEYQRYALFKVSGTPTLAVQFSSQVPGVMFGDAFRVEALVMFTQVGSGASAEVTMRVFGYVQFLKNVWVKGRILSTTMDTELPEGYKKMAAMVVAKMAGQSSAAPAVAAAPAAGEQVIRPEVSSPNPSLKPQTALQRSVMAHGTTALAALVVVVCLRSAWQTFFIARMSVSKLCVAARVGESDHLDGVCQMMIAEWNGVLSAARPALVAVYFLLISIFCGVTFKGIALSEAYGEGRRTSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S6N8</accession>
    <name>A0A088S6N8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_180050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697839.1">
        <property type="nucleotide sequence ID" value="XM_010699537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S6N8"/>
    <dbReference type="GeneID" id="22573895"/>
    <dbReference type="KEGG" id="lpan:LPMP_180050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180005600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_180050"/>
    <dbReference type="eggNOG" id="ENOG502S7IY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272625at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="974" mass="106165" checksum="DDA56B8C1A2EBA4C" modified="2014-11-26" version="1">MAATTDGRASSVVRCAEWLHKVVPCWLDADASVHLEDALREVEIWLSCVSAYATKGGHLPVKAALRVQLVTLDSWNTTALSGWPSERQDLKVQLRWLVTQLYLCSHCVFAESAVREAHLSHHLDDAEKCILMCLKTSKDLLRTRRTDAADKVLAWAACVVKACGGTPGATVRKFSVEVHFAQLRAAWEAGGYDHACDMAAKLADEARLSPAYTEALFELIYSIGVKSLQVDHFDADPCGGHVRSASETEGVALPPRASAGRISDEQAALQTLLLLSLRLQESIKVRTVKQRTFFGMTQLQYAYSLLLCGKYDDAADAATASHAILRTVEPIVVRFKAEVHRHATNEVLPLFGALCGDATVDVGDLCAMASLAMEKIPSLQETLFSELHRRVAASAIAVDQFRLLCVLIRHSSEWSVAELLRRLSKGDLPPPTFHRFLFCCLWQLSAKTVEEQPRNLSVVTRWCCLDAAQRLFRNVASEEELQSVLLDMAQLAVELHVDGREATKELEQTLRLCQQVKAIVPALEAPLLQAQSQVAFLLGKSEQGMERVKALLNCTSEETAVRTCSELVTFLLCSSLLPLAGAVAELCVVAFHQHQSPLCIIEFAKVFAMGCLVEESEQIRAEVGSILEAHVCPVLQHVTLTLPDARWWSRFLWYAAEALLDSDPGRAVRLLHAGVELQADRSDACEAEMAATASVGFVCERLCLLLDTEFDTFAAGQAALSTAELQRHSDSLASLLSSCIDEKDSADGRFTPPQRITLFLARLEVKLRDVLARDVSVPIDMEALGLAELPSMTGIGSVDLEQVATVCHHVALRLSPPGSYSLCDAALTIMLAAAQLKLSSGVVSTPALGSLFATIYSAFRIARNADGRLLVCEVLITALPFLTANGASLHSASSHLHDHYGRSSSLKGDLGLCETVVEFFAVEAWNESVQCNILQRRALVERWRTITAALTSVLSDTNASKAAIADLAAQMPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S753</accession>
    <name>A0A088S753_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_190540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698049.1">
        <property type="nucleotide sequence ID" value="XM_010699747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S753"/>
    <dbReference type="GeneID" id="22574108"/>
    <dbReference type="KEGG" id="lpan:LPMP_190540"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190014100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_190540"/>
    <dbReference type="eggNOG" id="ENOG502RXD6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="252716at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39669">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39669:SF2">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839260" evidence="2">
        <location>
            <begin position="26"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="526" mass="57937" checksum="86056546E9B86A9E" modified="2014-11-26" version="1">MAKTAHLVGALLALVMCLAATAVSAQRSVECQMVWTGASSNNSLLACLGNKGRIQSQWAFYLYPGFAALIFISTLIVLPIVFCCGCCKACATPEEVKDIGVARCYLWMWIVISVLMACGVCVLLVYGAVLLGQTANQIISDVENRTLDYFNETRMSITTLLTNYSASPPTPPTIDLNAFDSLNGNITYYAHMVRESYLKYFRIAEIVACCVGGVGIFLMLCMLVFAACRCSGCCPIAWSCVYFVFALVFALLAVLFTVSIYVMFAGCGEVNLQYKRAPGIFQWYLVPWCREEFNFRSVRAEVQAQEQRVSQSACSALLMFCDNDPVYPGTDKNHIFMCGNNITSAEQCKSLDDVVTVVLSTYVKPMLTNTLCANRTDMTQLEKCTLEDCASMCVDYQAPFLPAKTYATQIIQAVNFAANASTALSYVYPLLECNFIIDKVANTVESLQYDSSFTAKNYDVHSCSAIRTSSVMLGTGFFVGSLMYILGIYVMHRGAWVWAERKVQCDTSEKRLGASSTENVVAHNAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S813</accession>
    <name>A0A088S813_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_202170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698418.1">
        <property type="nucleotide sequence ID" value="XM_010700116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S813"/>
    <dbReference type="GeneID" id="22574426"/>
    <dbReference type="KEGG" id="lpan:LPMP_202170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_202170"/>
    <dbReference type="eggNOG" id="ENOG502SGQK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267606at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39668:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39668">
        <property type="entry name" value="HYPOTHETICAL TRANSMEMBRANE PROTEIN L6586.03-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="236" mass="25713" checksum="F7808FEAC1256C51" modified="2014-11-26" version="1">MPASSSSATAAQVLMHAMVSSSSSRRRLRLVLGTFCILNAFTAFLFAWMMSTEQTSFALTAARRRWNLRERSNATCKAGVYYVVIGLMLLVDRLSRTIAVIVQLGVRFVRAGCSLILRWLLWCARVIPASRGRGLLLRRFVTRSAGALPENYRVLLQSNSSARPPRSPPSAAVPATGAARAPSSHRLLPRIAGIHLGSSLQGAQASSTLETLADLERDRRPRNATASPPSIRLRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S842</accession>
    <name>A0A088S842_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">40S ribosomal protein S19 protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_202500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698453.1">
        <property type="nucleotide sequence ID" value="XM_010700151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S842"/>
    <dbReference type="GeneID" id="22574459"/>
    <dbReference type="KEGG" id="lpan:LPMP_202500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200030300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_202500"/>
    <dbReference type="eggNOG" id="KOG3411">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="428974at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000593">
        <property type="entry name" value="40S ribosomal protein S19 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001266">
        <property type="entry name" value="Ribosomal_eS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01090">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01413">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN97746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="160" mass="17950" checksum="A2408F30C4F4014C" modified="2014-11-26" version="1">MAALKNKIRRIGKRKGATLKDVSAWRWIKTAARHFKQEGKIFVPNCTELIKSSHGRERAPQNPDWYYVRCAAVLRAIYLRPGVGYGGLSKRFGNKKNYGSRPEHTVNSSTGPLHWACKSLTKLGLVEPGAQSGQRLTRKGHKFADSLAFQVQIRKFGASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S8J6</accession>
    <name>A0A088S8J6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Kelch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_204420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698643.1">
        <property type="nucleotide sequence ID" value="XM_010700341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S8J6"/>
    <dbReference type="GeneID" id="22574653"/>
    <dbReference type="KEGG" id="lpan:LPMP_204420"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200051000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_204420"/>
    <dbReference type="eggNOG" id="ENOG502RXXK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="432528at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000160">
        <property type="entry name" value="Kelch domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="45608" checksum="60C6B3310902B75B" modified="2014-11-26" version="1">MLLSSDARDGGREVALPFCWLYGVSADRPSIAPPVVPPPGCCHSLVSYQDRYLILFGGGSLAHFANDVFVYDMDSRRWSRKTPENSDMVPPRLAHSSVIHGDKMIVYGGQDLCSPVVYDDVLELDLATWRWSVLQHAQAGPGGPGARRLHNAHVVGNRMYVLMGTPAPPRETPLWYLDLHTNVWFHLQPTISHDSDTADEPAAMLSLCGCSSAASGDCIYLFGGYFAEDGERSSLSYREYVNSLFEYNTRLNMWRAVRLHPLAPCPAPRYAASLAVHANCLYLFGGDANQSDVSLYFSDLWRIRVQDDLATWRKVNVAGALRPSARSGCAYTCARASLFIVGGELPVSDVTIPWLYTADLFQLPLGYSGQLTLRVAVARWLGAAAGQFRELSSLPEEFPLTLGARCALDEYFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S9K8</accession>
    <name>A0A088S9K8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_220270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699028.1">
        <property type="nucleotide sequence ID" value="XM_010700726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S9K8"/>
    <dbReference type="GeneID" id="22575073"/>
    <dbReference type="KEGG" id="lpan:LPMP_220270"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_220270"/>
    <dbReference type="eggNOG" id="ENOG502SB9Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277602at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="143" mass="14893" checksum="1397EE740C6283D4" modified="2014-11-26" version="1">MRRSVYYMGRSLTRRHLNACNSPLATGFVRPNAFSSTMHGLAASPLCGLGFIGGGGAVIGANGALVASSETALSQLLTSIIAQGKPVSALATVVCIQNISSCVCACVRVLLGLTLKMFSPFLTTRGDTTVTLYAPSLKRDEPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SAD4</accession>
    <name>A0A088SAD4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleoside triphosphate hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_231620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699318.1">
        <property type="nucleotide sequence ID" value="XM_010701016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SAD4"/>
    <dbReference type="GeneID" id="22575367"/>
    <dbReference type="KEGG" id="lpan:LPMP_231620"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230024200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_231620"/>
    <dbReference type="eggNOG" id="ENOG502SHTZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267121at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11667">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11667:SF27">
        <property type="entry name" value="ADENYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="275" mass="29137" checksum="0AB7FE8574F1BB40" modified="2014-11-26" version="1">MASAAYYKKQQAQQHLANSEVQSITETLVAAVAQSRTRSPLRALLQTLDRMEGEGAESTPAAATTAPPLVTPCLILLAGLPGCGKSVQASHIAAFLGGVPCAVPSLVQDALNGGRLPGSKDVYVPQSLQVELRAAKKALAQHVASLPPDLVVRLIVNRMQYETRQRQAAAGTGFTPGEQLPSSKVFFVLDGYPSTIAEALALEAAAGQEISVVITLRCSTDCLQARHRSPVPPACHASLSIFEEYWSAQHKLRVVDGAQSIAAVTRRVLAVLQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SBB2</accession>
    <name>A0A088SBB2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_250880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699658.1">
        <property type="nucleotide sequence ID" value="XM_010701356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SBB2"/>
    <dbReference type="GeneID" id="22575736"/>
    <dbReference type="KEGG" id="lpan:LPMP_250880"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250014800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_250880"/>
    <dbReference type="eggNOG" id="ENOG502SAXY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266596at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="637"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="659"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="749"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="809"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="821"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1119" mass="121073" checksum="A0C5726CDA8E0509" modified="2014-11-26" version="1">MFGGPGRPRVAPRPPSDDSRLGGKASESVAGDFSTCPALRCPASSIANQIGGSAPSSAGDPQTSPSPCGIPRNRLYGTGTHSNPLEHQYHADEAPPSSSVVATTLSMATPHRYQQLAAQHLYGAANSSTAGVPAPCPSAPAADSCSAAAGTMPSSILRYTDPRVRPLPSAQGSSCLLSGAKQDSGGGGPAPGNQIVSSSGQNSGVKEGCSEANELSTQEKLEVIDGTALSSSSAHERGDQPTSAMRRAASAHEACQLSPKLSRSSTAAPLSSVAVAATADDRARSRGSATRREQQQRLQRQRTPWFPSRTATPARSTSSKHLPPPRTAQWAVKLIEDFVAQVALQQESAAMAPTIVPLYGATSALGRKETASGRDATTTTTVADLTATFLSSRYGMLQWRRILHEFAACLHRYRRLSPTCAVFREYFIHVDTENLGDFYLFCRLYAASDIQHCSRVETQRVAFVTETADNAHTIVSRRYVDEREVPDRLQRMLQYVVLMDCSPRLVVGVDSGAVSRTASGSVSTSRRPSGCVQYRYARDPSACVKEVPQRRHLTDDEVRRVKRAVLDWMEEAICKCTHERSYGAVESHEDDGAEEDARCETAGGDLLRISFDREGWVDAYALLQTTLEVVKLACRARHPSPQRRDEDASQAGDGACGFERNEDASDRSQRLLQQWRLAGSSARRPPLQRELVPPPPHTHSYPLEEVTPPRSRPQHRSPVQCSIRPTGEDEDGAEAPYVTQKRQAPSYMQPRTSVFTGTSATRGSADGCLSSPSREWVTSRRHRASTGQRTSSRSPRRRVAAAEERRQNPPASQMQEQGQSNRERKADESRLRSSYDESFFAAHEGPYYHHPYVAQLHGNQLWTEAQKEAAAASKQRGSCWGDYYPRIYSRVHGTPSPRKPAHEPCAAQSTFAFSTSSVDATIDSIDAELHRPQARVRDDGLSDPLQMTARSVDRSPRAFPAPEMLFFTNRQETRCTARSTDGLPLPPSFSLIAPPVSTVAYPGRVHPIAVRSLGSTAPAARATRVVDSTPAGSTLPILSPCAMSCTTAAKEPVASATPHSSHEAAAAVTSNTVLLTDEEQAMLDELEIALHRLDTRRRRDSATITAAAGDAPAVAKAYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SDU1</accession>
    <name>A0A088SDU1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_282940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700633.1">
        <property type="nucleotide sequence ID" value="XM_010702331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SDU1"/>
    <dbReference type="GeneID" id="22576739"/>
    <dbReference type="KEGG" id="lpan:LPMP_282940"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_282940"/>
    <dbReference type="eggNOG" id="ENOG502T0K0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10529944at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="116" mass="12741" checksum="A8CD7FBB2AE05877" modified="2014-11-26" version="1">MESLHLALGQYERGDLESTGDCLPRGALLFRHQEPSQSRCVGHAITNSEALEAERGNRTRAEEQLTRCDAAMRRLRDGTAPAPPKKKEVLLHDQLAALQQQNAAQLEGLEARVTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SEK7</accession>
    <name>A0A088SEK7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">tRNA methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_292550</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700859.1">
        <property type="nucleotide sequence ID" value="XM_010702557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SEK7"/>
    <dbReference type="GeneID" id="22577018"/>
    <dbReference type="KEGG" id="lpan:LPMP_292550"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290027900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_292550"/>
    <dbReference type="eggNOG" id="KOG2198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6093671at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808:SF27">
        <property type="entry name" value="SAM-DEPENDENT MTASE RSMB_NOP-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="7">
        <location>
            <begin position="51"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="607"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="621"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="158"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO00202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="630" mass="69457" checksum="2C36EA69AD16CE91" modified="2014-11-26" version="1">MSRNQNRKGGSKRGRSDEWITDARYPADLQNKAFEAYYKDNVIPASEWKAFMSCLQTGLPMSIRFNCAVPQVNAVDTFITQYLSEVFESKRIPFFPAQRAIQFGVSRGDLKRKRVNRTLKKIISAMNEGGYLTRQETVSMLPPLLLQVEPGMRVLDMCAAPGSKTSQILEYLLSGNAERGVVVANDVNVSRLDVLHHQTNRAAGAHLHVIITNADATRFPLLPPAERFDRVLCDVMCSGDGTLRKSIDMWPRWDALQGANLHHSQILVLLRGMASCKSGGIVVYSTCSLNPVEDEAVVSACLAQTKGTFELMDPTPLLPGLCASPGMTSWTVTTRDLTTVLRTHEDAKTFMMAQTARRTFQYAPSMFANTELLAEQHIERTRRILPHSQDTGGFFVAALRCIVAVPEDARPRAESILDANGTPALMKPLSDGMRATVQKALMLPDTFPYDHLIVRNEEARNQKVYLANPDAILLSQKLGCRIVQVGSKVFESVVKYRNDTLRFCPDGVADLVPFLPSNFLVPVTPLLLLELTAETPMSYTDFSTKTGQLTEELPPSFVLTTSWPVGGPIYVAAERSTKLGKVVAHVADWQVTVCKLALNLPLVESVEEGQEDSDATRKDAAVPATDAAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SG91</accession>
    <name>A0A088SG91_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">RPOIILS</name>
        <name evidence="17" type="ORF">LPMP_312440</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701632.1">
        <property type="nucleotide sequence ID" value="XM_010703330.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A088SG91"/>
    <dbReference type="GeneID" id="22577670"/>
    <dbReference type="KEGG" id="lpan:LPMP_312440"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310031800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_312440"/>
    <dbReference type="eggNOG" id="KOG0260">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02733">
        <property type="entry name" value="RNAP_II_RPB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000013">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007075">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007073">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038593">
        <property type="entry name" value="RNA_pol_Rpb1_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF37">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04992">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04990">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 14" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 14 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="16">
        <location>
            <begin position="218"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1629"/>
            <end position="1662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1645"/>
            <end position="1654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AIO00832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1662" mass="184420" checksum="44EA5E5E1FB76DE0" modified="2014-11-26" version="1">MSGGAPLPPSQMPLQKVHEVQFEVFKESQIKAYAKCIVEHAKSYEHGQPVRGGINDLRMGTTDFEYSCETCGLKHPECPGHFGYVELAEPIFNINVFDIVLIALKCVCKYCGALLMDTNDPSELKKIAHLQGLNRLRMVAKLCGSVCKRSKDIQGCEGKGRQPRIGRFAGIYPGLQIKVTQEEQDYVWHADNAWQVLDRVSDSDALIMGFDPRCCHPRDLILTVLPIPPPQVRPAVSFGSAKSDDELTHQIMSIVKRNIQLSKDKESGVKAAVDRSRALLQEHVATFFNNASTFYKPAKVGDTKKLKSLTERLKGKYGRLRGNLMGKRVDFSARTVITGDPNIDVDEVGVPFSVAMTLTFPERVNVINKKRLTDFVQRVTYPSANYVIRPNGNVTKLALVKDRSAVNLDVGDVVERHIIDGDVVLFNRQPTLHRMSMMGHRVRVLNYNTFRLNLSCTTPYNADFDGDEMNLHVPQSLLTKAELIEMMMVPKNFVSPNKSAPCMGIVQDSLLGSYRLTDKDTFVDKYFIQSVALWLDLWELPIPAILKPRPLWTGKQIFSLILPEVNHPASPYDKPPFPHNDKKIMIQRGQLLVGSITKGVVGAAPGSLIHVIFNERGSDEVAKFINGVQRVTTYFNYCFAFSVGVQDTVADATTLKEMNNVLHKTRQSVEKIGAAANNGKLTRKAGMSLLQSFEADVNSALNKCREEAAKKALSNVRRTNSFKVMIEAGSKGSDLNICQIAVFVGQQNVAGSRIPFGFRRRTLPHFMLDDYGETSRGMATRGYVEGLQPHEFYFHTMAGREGLIDTAVKTSDTGYLQRKLVKALEDVHASYDGTVRNANQELIQLVYGEDGLDGARIEGNQAFPIPHMTNCELVDKYRYEYNDEGSFSENMGGHYMDPFVRDSLLRDPQSVLKLQEEFDQLVKDRAMSRLVIDMEDKNKLKMNLPVNVARLIQNARTTMGKRSQVSNLNPITVINRVRELQEDLVQLFPSYHKDYNGRFVNVLSQQRVERALTLFGIHLRQVLGSKRVLKEYKLNDKAFEYLLKEIRTKYQQSLITPGEIIGAIAAQSCGEPATQMTLNTFHNAGISSKNVTLGVPRLLELLNVSKNQRNASVAVCLIREYQKRNKAQEAQQFIEYCTLANITTTVQIIYDPNPRNTVVAEDEEMIRWEQAVMNEEEEEQDVEQPPSPFIARLILDSDLFNDKRLNMKDVKSAIRQVDDTYTVQANMENDGQRIVRLRPRKCTGADSVPALTKAVAQLLQSVHLRGIPGIKKTLLKEGNTFRVDPETGGMKNESSWMVDTEGTALQRIFVGVVNNEGKNIIDFVKTSSNKIPEVVSVLGIEAARRKLLFELRDAYLAYGLNINYRHYTILVDTMCQRGYLMAVSRTGINRSETSGPLMRCSFEETVKVLMTAAAFGEKDPVRGVSANLVLGNQARIGTGLFDLMLDMSKLQHVVPLDKATEARTSNVYHTDTSVAPGSSTLQGPYGELPPSTVHENSSLAAGTSSVYPPHRGAGLYGGIPIEASAVQFSSILPTTMGSALVASNTSEYQSSHHLSGASTYLASSALPSTSALDTELSSYHLQSAANSTAYGYAPMVAPRIPMPGGAQLPVGEGASISYPYEASNGDLFGSLGGAASSRASAPYDPTQQPSQEFSPTEEQEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SGB9</accession>
    <name>A0A088SGB9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LPMP_312830</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701667.1">
        <property type="nucleotide sequence ID" value="XM_010703365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SGB9"/>
    <dbReference type="GeneID" id="22577709"/>
    <dbReference type="KEGG" id="lpan:LPMP_312830"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310036100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_312830"/>
    <dbReference type="eggNOG" id="KOG0589">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08215">
        <property type="entry name" value="STKc_Nek"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000535">
        <property type="entry name" value="Serine/threonine-protein kinase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="42"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="12">
        <location>
            <begin position="345"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIO00867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="441" mass="49773" checksum="3808D13715D37745" modified="2014-11-26" version="1">MEDPDQRKPNGGNNGLPVPPSTTETGKDPLQGILGRMPDCQYVKKRLLGQGSFGSAWRVEESATGSVFAAKVMDLNSMSEKDRGFVTNEVKCLSRSRNPHIVRCENAIEREGHLLIVMEYADGGDLYKQIKARVREMKFFREHEVVFIFLQLCLALDHIHSNKMMHRDLKTANILLTTTGLVKLGDFGFSRQYEDSLSNAVGSTFCGTPYYLSPELWHRQPYSKKSEMWALGVVLYEVMALRRPFTGKNMDELITNICHGRRADLPPSYTASLRDVCNRLLSVDANMRPTIQELFHEPFIRSNLETLKRSVEKHNRIPADVRDAIARCITQSLSTEEPPAQLEEPSPFIGTVSRHTALRGWQKCLLSFDKKQISIRDPSGVDPEEVVPVATLTSVCPIDVMMAGEEFVFAMKNQAGKAFWFMAPNQKAYEQWLSTLQEAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SIF4</accession>
    <name>A0A088SIF4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_333120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702402.1">
        <property type="nucleotide sequence ID" value="XM_010704100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SIF4"/>
    <dbReference type="GeneID" id="22578465"/>
    <dbReference type="KEGG" id="lpan:LPMP_333120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330039300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_333120"/>
    <dbReference type="eggNOG" id="ENOG502SK5P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266422at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35615:SF6">
        <property type="entry name" value="KINESIN MOTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35615">
        <property type="entry name" value="PRESENT IN THE OUTER MITOCHONDRIAL MEMBRANE PROTEOME 22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="982" mass="106647" checksum="D5ABB3694A1C6AAD" modified="2014-11-26" version="1">MGRRKPTQPVETEVMQRHQSACKRRGSFTACNTGPNQNKNSGNQEPSGGGGDLAREHNSHLSRNRLKNGTSFRRLPQDQGSGGPAPYTSFNFVSPPQQHQQQPQQPQRQPHQQQQQPHQQQYFHQPSPQSYDKYSSQPTQNAQGQPYLPYGGNYESLPPQQLIHLRNLPPLPHVTTPQGPMAPPPLYLFAMQGCPLAPGMPPQQQRQRCEPPGSSNRAVPPQHYAVSGNAMPSALQPTLARRPSFIATKGRTVNIAPNAVPPTVVDPRAGTTDGTRLTRAHSILKHTSSFKKQAHPTSEVAKVGQKELTMDQRLHEREQERQRLQQEMQARMASEQSAREQRLRELEHRKVPQNVVPESLANTSPCVQAGLPNPGFHSGDSVSESCRVPASKPVPSSQLPTSVQSLPGRPTGSVPFSKALQRHPVSKLVARSPASGESPGMAALVEGHSKLPASDGADNLTMLDPKGNGRVAASGGGAAAVVAKSKGPARGASATATAEAPAVAMQQLWHCCLSLALYEIPLRCRKTVKNDEEHIDDSKFPVRLFGSTLRVTDAVKQTSTEYQLDEVVTHRRGSTNVESNLLEKVGEVLIEGYSASVLSLDSKGLCKSTSAFDSAAWLAKQRLLMNVLRRVKGMQSVYSERVGSGDFFEAAFSFAIVKKVSSQQAAEWNITSVATAQRTYGVVDLLQPEPTVVQFKMDGCLLFGHRIAGVEYRALRSEAEFKTVLTSAQVNANIVLGRLADAVAADPDNEAAANEQESVLQVITCVLTHRKTGPVSLQEQMVEPAEAVYKREAERDVMSSDDEDDTDLPTVFRSHNVPSGCSDIIMNCLTCIGAQQSHGLWAAALERNQRIVPTALFETAFGGPAYTVILASIDPTKVESAAALDTQSAMSLKLHRRPLNGSARRFIQCSKYVTVALQTKLSGTIPPSDAQQRDLKAEIHKRAMGLDSLGKMLSSLETNGFRVSGTTSFAQVHRAEACARKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SIL9</accession>
    <name>A0A088SIL9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Coatomer subunit zeta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LPMP_340090</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle</location>
            <location evidence="12">COPI-coated vesicle membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702437.1">
        <property type="nucleotide sequence ID" value="XM_010704135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SIL9"/>
    <dbReference type="GeneID" id="22578513"/>
    <dbReference type="KEGG" id="lpan:LPMP_340090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340006100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_340090"/>
    <dbReference type="eggNOG" id="KOG3343">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10249988at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000033">
        <property type="entry name" value="Coatomer zeta subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039652">
        <property type="entry name" value="Coatomer_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043:SF0">
        <property type="entry name" value="COATOMER SUBUNIT ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043">
        <property type="entry name" value="ZETA-COAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="13">
        <location>
            <begin position="7"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIO01637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="184" mass="20263" checksum="60430D704B990F29" modified="2014-11-26" version="1">MAFLHRVQAVVALDNTGSRIFAKYFIGDDTPESSKALAPLEKQRSLEHSIFQAIHDPRRGNHVAYENDILVVEGHITVFHVSEDVTITVIGAGSENEVVLSNVLMGLVDALRQELNTPSLTVRLLLENYCALLMTVDEMLDEGIILETDSATVANDLEPYLVDVSNDTARAALTGVNKYLRDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SIR8</accession>
    <name>A0A088SIR8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">fumarate reductase (NADH)</fullName>
            <ecNumber evidence="6">1.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">NADH-dependent fumarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_340760</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>succinate + NAD(+) = fumarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18281"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.3.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.3.1.6" evidence="6"/>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01702.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702502.1">
        <property type="nucleotide sequence ID" value="XM_010704200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SIR8"/>
    <dbReference type="GeneID" id="22578580"/>
    <dbReference type="KEGG" id="lpan:LPMP_340760"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340013100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_340760"/>
    <dbReference type="eggNOG" id="KOG0534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2404">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10252157at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016156">
        <property type="term" value="F:fumarate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000021">
        <property type="entry name" value="Cytochrome b5 reductase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000007">
        <property type="entry name" value="NADH-dependent fumarate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.520.10">
        <property type="entry name" value="ApbE-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024932">
        <property type="entry name" value="ApbE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003374">
        <property type="entry name" value="ApbE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010960">
        <property type="entry name" value="Flavocytochrome_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01813">
        <property type="entry name" value="flavo_cyto_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF7">
        <property type="entry name" value="FAD-DEPENDENT OXIDOREDUCTASE 2 FAD BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02424">
        <property type="entry name" value="ApbE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143631">
        <property type="entry name" value="ApbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00050832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00077246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO01702.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1194" mass="129438" checksum="161B397FF2C6D38F" modified="2026-01-28" version="2">MGASAMATQRRCTVSDSHTGASIVVVNPEKAARERDRIARDLLTTNFPELHVDQRSVLLYKDVVHTVPYTLSIAVDGSVTRQDADPVVKAILSNCFTMVDTHLNSFNPDSEVSKVNRMLVGEKHVMSEHLCKVVKCCEEIYNISGSCFDPAAAPLVHRLRNAARRQDSTEADFMITAEVAGRFTLTNSFAIDVKEGTIARKHEDAMLDLGGLNKGYTVDCVVDQLNAAKFSDVLFEWGGDCRASGVNVQRQPWAVGVVRPPSVDEVVAASKSGKSVTMNAHSLGERSDEPAQSASAADGAAKPGHKTLLRVMSLSNEALCTSGDYENVLFVNALNRAVSSTYDWRHRCLIGPSQGGLAQVSVKCYSCLYADALATASFVKRNPVPIRYMLEHYRRDYNRVTDYTAYTREGERLAHMYEIACESPACRTERIAGSLPARVVVIGGGLAGCAAAIEAASCGATVILLEKGARLGGNSAKATSGINAWGTRTQAVNHVLDNCKFFERDTFLSGKGGHCDPGLVRTLSVKSAEAISWLESFGIPLTALYQLGGASRPRCHRAPDQKDGAPVPIGFTIMRHLENYIRTKLQGKVTILCETAVVSLLHDVSAMPDGSREIRVRGVRYKSTSDASEAVIDLPADAVVLATGGFSNDQTVNSLLREYAPNVYGTPTTNGAFATGDGVKMARQLGARLVDMDKVQLHPTGLIDPKDPSSKTKYLGPEALRGSGGILLNRNGERFVNELDLRSVVSQAINAQDDEYPNSGGSKFAYCVLSEEAAKLFGKNALTYYWKSQGLFTRVDDIKALAELIGCSVDNLHRTLETYEHQSTAKVACPLTGKLVFPSVVGTSGPYYVAYVTPSIHYTMGGCSISPAAELLMEDHSVNIFEDMRPILGLFGAGEVTGGVHGRNRLGGNSLLECVVFGKIAGDRAATILQKEKYGLSKDKWAPVVVRETRASDQFGVGSRVLHFNLPGATQTSGLTVGEFISIRGDWDGQQLIGYYSPISMPDDKGRISILARGDKGNLQEWVSSMRPGDSVEMKACGGLRIELKPQQKQMIYRKTVIRKLALIAGGSGVAPMLQIIKAALSRPYVDSIETIRLVYAAEDEYELTYRSLLKKYRTDNTEKFDCDFVLNNPPEGWTEGVGYVDRATLQSFLPPPSKGLLVAICGPPVMQHSVVADLLALGYSAETVRTVDEDRML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SK21</accession>
    <name>A0A088SK21_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease, putative</fullName>
            <ecNumber evidence="7">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">AAT27.1</name>
        <name evidence="7" type="ORF">LPMP_345180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="7"/>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702937.1">
        <property type="nucleotide sequence ID" value="XM_010704635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SK21"/>
    <dbReference type="GeneID" id="22579023"/>
    <dbReference type="KEGG" id="lpan:LPMP_345180"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340060000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_345180"/>
    <dbReference type="eggNOG" id="KOG1305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28208at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF649">
        <property type="entry name" value="ACID TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="11"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO02137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="410" mass="45189" checksum="658DC60BC6A2D329" modified="2014-11-26" version="1">MNFWEHFSDCSVVGSALSLSVTTIGAGVLVIPSTFQDSGICLVVGVLILVGALTVLSIDYLICCVDCLHLKSYEDISRELLGRWCEETVRWILIIYNIGIAAGYIVLIGEIFTPLLPLLQPYLPFLTDSSHVMISAWVFVMLPLSCIPKITKMNYISFVAITATFLISAIIAYRYLVPFDGERNHAKVTYLPCNERAFLTLPVMMFSFDCQSLVFQIYSNLKMATRTTMARVASLSVGITGSLYFIVGLFGYLTNTPNITGNILTNYDPIKDHLFALGEVVYSLTVMVAYVLVLFPCRDAMFIFLFGYNTATHELAHEAITTSHNLIVSVLLSTVSIFLAMRATGIVVIIALLGGLCSSTICFSYPAAFRIMLHIRGLDRCKPTELVTAIFMLVFGMLGGIMGTVIALRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SKB3</accession>
    <name>A0A088SKB3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_351150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703052.1">
        <property type="nucleotide sequence ID" value="XM_010704750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SKB3"/>
    <dbReference type="GeneID" id="22579144"/>
    <dbReference type="KEGG" id="lpan:LPMP_351150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350017100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_351150"/>
    <dbReference type="eggNOG" id="ENOG502QTXC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="274949at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO02252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="370" mass="43983" checksum="C5FA5516C1B307E7" modified="2014-11-26" version="1">MLRRASTLPQRVAVRRPSLTAAGVAVVFAPSNSFAYWVSRRDYHGFQFASFHGWTLPYGGKSTRVTKEELENQRFFTERPREKWDYHRVDENINSQSELRNAEGREQFYQGSREDNTTTNHGSLHTPPKYRLYEYFDEYTKPGVNTKVAAAYAVKEQWDAEEFYYPGEAWQRNRPGFRSVPKELLNRQTWYHWSHALTKWDEIQPTIRTRSWNPDWPPPGYEVPKLQCKKEFYFGMEDEGLVSEVERYNWFRSWSDSNMRVGWREIPLFMMLLGTLYLIARNAMSVTVMRAMSSNMYYPGRTFIRPFGVPKDWEKECFWWQRPLEEFPNQDQVWYWTHARFGYINYIKQRDAREKAMMDAEAAAAAAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SL11</accession>
    <name>A0A088SL11_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH-ubiquinone oxidoreductase complex I subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_353600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703297.1">
        <property type="nucleotide sequence ID" value="XM_010704995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SL11"/>
    <dbReference type="GeneID" id="22579389"/>
    <dbReference type="KEGG" id="lpan:LPMP_353600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350043900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_353600"/>
    <dbReference type="eggNOG" id="ENOG502RIJY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268776at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="259" mass="30289" checksum="63FF3F3C110B8707" modified="2014-11-26" version="1">MTVAGGVDSGDSHAYDDHRGHHGAVTAPYEKIKAPSMASQDYLENLPAFDTTKPMPQPRSAVERFTRVLQMQFGQDPDMPVFGVNSERKYHSLFDYLASSITPLRPRTYVDSYTRPNPCPEEYWWASWRWPRTKYVNAKVPPPVDGKYTDYYHYLAFKNWLERERDVYVAHANLVHEMTSRCLVKEGQYNAAKNCRHLYHKEFAMSRMEEFNQAMLYMAMTGNAAIRETPYPANFVEEKRKIYDDWLYRTRMRKPGDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4M7</accession>
    <name>A0AC62A4M7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">p-glycoprotein e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_311200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="XUY36693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1538" mass="167182" checksum="C1EEAA0BE6A1B1D2" modified="2026-01-28" version="1">MHSLYGAEPSYAVQAEDRSGWIFGALFYTWIGDLMQRAAREELSADRLPHPMREYRAYNAGVALAAELQRQRARRHAWDGYVGARVGVLWDDASDGVLRWVGAVQQYGTPQQLYAGVEWRVAPSRRCGGWAGRCMRRLLCRRGRSPVPEHGPGAYHRGEVDGEHLFDPVEDDTVLTCERVEDVFFWREKPEGEARGASATGEGPGGDSEGGGGGTSAESGIGIPAPPTCMSVTRALIHVLRWQLLLLGLLRVTVEVSTLLTPMALSWYLRLLQSSADTPSAESASSGASSAAATSSELSSSAEGESMRGGAWQTLASVLLLFSIALVRSLALQKYIQVVHRNAYAIRSALSSCVTAKCLCIASRELRRPELNPGRIVNLISTDVASVESTLYVLWMTVTVPLQVCVTVFLLYRSIGQMAGISIVVLLLSLPVQVVLTRMTYAYTLDMAKLSDARIRFVNEFLSGIRSVKFMSLEDIFEREIDERRRVELRAVRRFQLVSIATSLLSQCVPTCTTAAVIVAYYRTGKPMSPAVIYPILSLLGLLDIPFEVIANLIGVYAQFLVSMRRLTSFLAADDAQAHDILEEALVSGEGDDASAVLCNATVSTYKAVPLPPPRSRRSSGEGDTHYELRAKTVLVDVDLRVPRGRLTVVLGPTGSGKSTLLDALIGALAVTRGRVACSRSVAYVPQQPWIMSATLRDNVVFFGAPDAVAFERAVRSSQLATDLALLADGAETEIGERGINLSGGQRARVSLARAVYADRDVYVLDDPLSALDAQVGERVMRECVCGALAGKTRVLATHHVSAAAYADLVVLLEEGRVAFQGSYAAYRDFARVHYERSLSGISKSWSYAAHTVSELASAVDLAKLDDVLEEKAALSRALTETALESNAAVLCVAHPLTHSVLSDALTEAVPNVTVVESGEEKAVGAVPWAVYRRYIEACGGWGTVCSILIFFLVTEAVSRSADVWLSLWSGGMLEGLSAYWRLAPYVASVLVAITVSPSRDLWCFTAMRRASYSVHAGLLHTLTRARLSFFDVTPHGRLINRMSRDMGLIDWDLPASVDILLFFLFYLVGYFLLMITSQPFVLVILVPAVVVYSRIFRFFCAANREMQRLLNISNSPVFSILSEVLAGHWTIRTYGRDRDVMREVLERLDGVFACAYMQCMGSNWLSVRVELLGNVAVSGLAVLGVLSTQLPWMHMNLGLLALTISKASSITMVLSRFIIYGASAEASMNCVERVLYYTDNAPTEDMGGCKSAVEACSSDALSAAADGGEAAAAAPAGSIVFEHVDMRYRPGLPLVLRDVCFAVAPGQKVGVVGRTGSGKSTLLLAFLRLVEVCGGRMLVCGRDARDYDVRGLRQLFSMIPQDPLLFDGTVRSNVDPFGRCGDAAVWRALRQVGMEEGVRGEAGGLDGRVQEGGANYSVGQRQLLCLARALLKRGSAFLLMDEATANVDPALDRQIQRTVQHTFRDYTVVTIAHRLHTVAACDAILVMDQGRVLEFGSPRELVEREGSAFSALVRSLSKGAQQAFRVALEERYGSASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4U9</accession>
    <name>A0AC62A4U9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3420400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="XUY36804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="426" mass="49418" checksum="9559EAD7F19D9C72" modified="2026-01-28" version="1">MMHFSGVVRRQMRPYYNLPSKSEHGRRMTGFLTPYRHWMWKQNELWRNVHEAQFEHLRKVYKRQWLESFRVNADEYIYKYNITKSAQLAQWEHEMQAQERKRRESQQLAQGRQALKKKHLDLLREFHERQFFYWYERASERLQYMARINYISQASIQEHIERELDKYTVGSKAPYPLNFAGQMPMLEDRDGNIAQVPANLMTNHATENPDGGATIYEPPEGTAVAEEKLLQMMASAQEEELRIRPEDGDAWSESMTDMDRSESARFDSRKVARSMEETDEEREVSRRAYIDRGKTGSKAIFRRPRFDGDGATSPSAGGTTPMKRRKSKTDRMHALQEQQDAAVAKATAKALKDEGSTAGATKRGEVAENRGRLRDRMITPSLETLQQSPEMMAQNKPGGRVRTHHLMEKVYGIGKFKKGGGGDEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4X5</accession>
    <name>A0AC62A4X5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NADH-dependent fumarate reductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3420100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="XUY36772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="543" mass="57545" checksum="4BC5586EA8412D02" modified="2026-01-28" version="1">MVSGTHAARLVLKKGHAKPAAPGRGRPRFPGRWRGMMATARGAQRLASDEAGVPHAKPRVLRHAGRFLLRGAPGECAARSRKNGSAWGTAVQKAAGVHDSGELFEKDTFASGKGGSCQPELVRTLSDHSAEAIEWLSSFGIPLTALTQLGGASRKRCHRAPDNPDGTPLPIGFTIVRALENYIRTNLSDIVRIETNARLISLMHSKEDDAVVVQGITYATQTASGEGKIRKLQARAVILATGGFSNDHTANSLLQQYAPQLSSFPTTNGVWATGDGVKAARELGVKLVDMDKVQLHPTGLLDPKDPSNRTKYLGPEALRGSGGVLLNKNGERFVNELDLRSVVSQAIIEQNNVYPGSGGSKFAYCVLNEAAAKLFGKNFLGFYWHRLGLFEKVEDVAGLAKLIGCPEENVTATLKEYKELSSKKLHACPLTNKNVFPCTLGTEGPYYVAFVTPSIHYTMGGCLISPSAEMQTIDDTGVTPVRRPILGLFGAGEVTGGVHGGNRLGGNSLLECVVFGRIAGARAAAILQEGGAGLPLQGGGQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A535</accession>
    <name>A0AC62A535_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histone H1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2720010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="XUY36914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="110" mass="11038" checksum="7E373C49FD3AD917" modified="2026-01-28" version="1">MFANSTGAAAAAASNSPQRSPHPSPKKAAVKKAAVKKAAAKKAAAKKAAAKKAAPKRAAPKRAAPKGAAPKKAVKKAAKAAKKAVKKAVKKAVKKAKKAVKRTAKKAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A596</accession>
    <name>A0AC62A596_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phospholipid/glycerol acyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2920140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="XUY36948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="421" mass="47692" checksum="8E38B040C1AFA552" modified="2026-01-28" version="1">MQLHNRMAQYRPTKATGVITPYLVHGVAEQYLRIPCAVFMWCIFVCGALAPFLRSEDEEDVTSRRCILWHLLTWGHAYLCTNGLFIATAFLVENARCLVAPGPRRLSLADDYKEGNPAKVDKMAAFVYDTPPDTYERVKMFCFMVTGVAFVRVFTALASIFLGLFTASVAGYFDRYAHPWWFGFWSRVTAFITIVVFAVLGVYSVPQYGQFSSRSECKILIANHSCVMEVIWLYVMGGFPSFVSRKENLSFFFFGNVVRGSSSILVDRDVATSREQTMKSIMQRAGDPTAPQLMIFPEGTTGNQQALLMFKKGVFEASMPVQMVCIAFPYKHFNPAWLGRGAGGNSLCDILLRLSCQFVNYAEVRLLPVYYPTEEEKKDPKLYAGHCQRMIATVLREKISDASFGDYKEAFRRFAELKKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5A6</accession>
    <name>A0AC62A5A6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Heat-shock protein hsp70, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2820180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="XUY36934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="654" mass="71302" checksum="17158A359508D667" modified="2026-01-28" version="1">MTFEGAIGIDLGTTYSCVGVWQNERVEIIANDQGNRTTPSYVAFTDSERLIGDAAKNQVAMNPHNTVFDAKRLIGRKYGDPVVQADMKHWPFKVKTKGDDKPVISVQYCNEEKIFTPEEISSMVLLKMKETAEAYLGKQVKKAVVTVPAYFNDSQRQATKDAGTIAGLEVLRIINEPTAAAIAYGLDKGDDGKERNVLIFDLGGGTFDVTLLTIDGGIFEVKATNGDTHLGGEDFDNRLVTFFTEEFKRKNKGKDLSSSHRALRRLRTACERAKRTLSSATQATIEIDALFDNVDFQANITRARFEELCGDLFRSTMQPVERVLQDAKMDKRSVHDVVLVGGSTRIPKVQSLVSDFFGGKELNKSINPDEAVAYGAAVQAFILTGGKSKQTEGLLLLDVTPLTLGIETAGGVMTALIKRNTTIPTKKSQIFSTYADNQPGVHIQVFEGERAMTKDCHLLGTFDLSGIPPAPRGVPQIEVTFDLDANGILNVSAEEKGTGKRNHITITNDKGRLSKDEIERMVNDASKYEQADKMQRERVEAKNGLENYAYSMKNTIADTNVSGKLEESDRTALNSAIDAALEWLNSNQEASKEEYEHRQKELESTCNPIMTKMYQSMGGGAGGMPGGMPDMSGMGAGAGPAAGASSGPKVEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5F0</accession>
    <name>A0AC62A5F0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Eukaryotic release factor 3, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1120040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="XUY36967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="745" mass="81442" checksum="791BEEEC16333DE9" modified="2026-01-28" version="1">MSWQQPTGSINPNAPSYAPDGSAYIGNYNAQGAGGYYPPPPPQQQQQYGGGGYYPQQGGQGSNYQGFYGNQADHQGDMYSPQQQWQGGSYPRGGYGGPQQQRGGYRGDSSYGNYQQGSGYGGQQEQRYLQNEAYQQQMPQQPAPPQQQQKQQRPAAPNPAPKTSASDAAKLSLGGGSAQPVVAPKKGGGTLSLGKRRPVTTAPQSSALAVASPVSPSMATEAKPESGAGPSATSAAESPAPEKESAAATQAERAPKPASAAPAKEAPTTTEKDRAKMTPEERRESVKKEIARQRQQSRKEYKRDPRPHFNIVFCGHVDAGKSTISGHLLMEKGLVDQREMEKLRREAEINHREGWEYAYVMDVSEEERSKGITRETGAAYFETEKRRVTVLDAPGHKAFVPSMIGGATQADVCVLVISSRTGEFETGFEKGGQTREHAMLVRTCGVKQMICVINKMDEMKWSKERYDEIVGKLKPFLRQNGYDEERAKNLIFMPVAGLTGENLIKHVELSHCDWYKGETMMGVIDSLKLPESKTDDDVLCIPLVGAYKDDGKTHIYGKVESGSIAVGEKIQVLPTKVEALVEGISIESTEFEKCYPGDNVHLHVRGIDESDIHGGYVATSIPTSLRAVEFFQARVVILEVKNIISAGSRVMLHIHSAQEEASFHKLLAKIDRKTNEVVERDPACVKAGDVVIARIELDRPVVLEPHKDFDKLGRFMLRDDGRTIAIGVVTRLYESTHESLAKAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5H5</accession>
    <name>A0AC62A5H5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RNA-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1820010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="XUY37112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="347" mass="38751" checksum="F76C8E2136CD3210" modified="2026-01-28" version="1">MSRKAKYQQESFSFTPSSTNLFVRYLSREVDDDRLRAIFSAFGNITSSMVMRDIYSGQSLGTAFVRYEKHEEALRALRDAHGMPLLGKTVSVQWAKQQHDGTPAGQERLRMNKLFLRNVPLEVTEEDLVDLVNSYGSVRKVTIHNDTAPFIDATERRRIVFITFAEQGAAEAALRAVHNTCAFHQCRGIPLMCKLSEDYTNRVRTPQAVPVPHSWRYGGFQRSRSSPYSKTMTPRSENSMSVEVAPRAKREYTAGYVGGGTLGVIETPRSVDSASSSLTHQGFYTNNLMEGWNLSCTQRMGGPACDFVATPMSTWRDFAGLTTIHARDSGITVTVRHRSSARGSQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5H9</accession>
    <name>A0AC62A5H9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histone H3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1620510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="XUY37062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="66" mass="7238" checksum="D87F239EB5F19D1A" modified="2026-01-28" version="1">MPCARCRACRRRGGPALPEQRDPGDPGGVRCVADGCHEPGQHPREACVTVRPKDVQLAVRLRGERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5Q3</accession>
    <name>A0AC62A5Q3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histone H3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1620040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="XUY37015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="66" mass="7238" checksum="D87F239EB5F19D1A" modified="2026-01-28" version="1">MPCARCRACRRRGGPALPEQRDPGDPGGVRCVADGCHEPGQHPREACVTVRPKDVQLAVRLRGERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5W8</accession>
    <name>A0AC62A5W8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histone H3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1620650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="XUY37076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="66" mass="7238" checksum="D87F239EB5F19D1A" modified="2026-01-28" version="1">MPCARCRACRRRGGPALPEQRDPGDPGGVRCVADGCHEPGQHPREACVTVRPKDVQLAVRLRGERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6D0</accession>
    <name>A0AC62A6D0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Leishmanolysin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">GP63-5</name>
        <name evidence="1" type="ORF">LPMP_1020120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="XUY37364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="584" mass="64143" checksum="F82829CB2AC5398B" modified="2026-01-28" version="1">MSRDRSSTHRRRSVAARLMRLAAAGLVMAVGAAAVWAQAAGHHCIHDRLQTRVLQSVAQQRRPPGSVSALGLPYVSTGPISSAHTVDWALDDSTSPSVAHSADWDTMRIYVSYADLTDPDYYCSYVGQLIDNHDGAIDICEAEDILTDAKRDILVNYLLRQALQLHVERLKVRRVQGSWKVTGMEGDVCGEFKVPEAHVTVGFSNTDFVLYVASVPSEPGVMAWAVICQVFTDGRPAVGVINIPAAYIRSPYDQLMTRTVTHEITHALGFDLTIFEEMKVIDEVSNLRGKPSAVPVINSPTVMTKAREQYGCPTLSFLELEDTGGASTAGSHLKGRNAKDELMAPSVTAGYYSALTMAVLQDLGFYQVDFTKAEVMPWAHLASCDFITKKCMERNITQWPWMFCNTTDVVLQCPTDRLAVATCKITHHEKPLPLYFQYFTDHSLSGDSTLMDYCPYVDTYPDSACDQDPSTAPEIFKEFNLFSDASRCLDGTFRPKHSTGLSEQYNALCANVKCDRAHRTYSVQVYGSSGYVACTPGQRVELATTSAAFVEGSYITCPPYVEVCQANIKGVINFEGDAADTAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6E9</accession>
    <name>A0AC62A6E9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amastin-like surface protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2021120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="195" mass="21821" checksum="4422187F17640540" modified="2026-01-28" version="1">MEFNPFIIVYAAIQFIAFLLVLVGTPLDIFRSRQRSIFNETSCVLLWGVKRNCSSIAYAATSDDRWVMCPTRRTHFRVARVFAVITIGVYCAAFVLGFIMLCCYACLRWVCLGLNIVGFVTLATLCALMVVSYETDAYPLCPKLKNDFTLSSGFFLFAAALCLDLVSIAFLFIPWSHENVEGSSSHSKEGNSQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RGS1</accession>
    <name>A0A088RGS1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acidocalcisomal exopolyphosphatase, putative</fullName>
            <ecNumber evidence="6">3.6.1.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_010310</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.6.1.11" evidence="6"/>
    <dbReference type="EMBL" id="CP009370">
        <property type="protein sequence ID" value="AIN95132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696674.1">
        <property type="nucleotide sequence ID" value="XM_010698372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RGS1"/>
    <dbReference type="GeneID" id="22571760"/>
    <dbReference type="KEGG" id="lpan:LPMP_010310"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_010007400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_010310"/>
    <dbReference type="eggNOG" id="KOG4129">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="374045at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.20">
        <property type="entry name" value="DHHA2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1640.10">
        <property type="entry name" value="inorganic pyrophosphatase (n-terminal core)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004097">
        <property type="entry name" value="DHHA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038222">
        <property type="entry name" value="DHHA2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112">
        <property type="entry name" value="BNIP - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112:SF39">
        <property type="entry name" value="EG:152A3.5 PROTEIN (FBGN0003116_PN PROTEIN)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02833">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01131">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="DHH phosphoesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHHA2" evidence="5">
        <location>
            <begin position="224"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN95132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="387" mass="42895" checksum="80946D777A224BD4" modified="2014-11-26" version="1">MSGIINDFLRRCLKKVAGKVQPLTVVQGNEGGDMDSIVGCIYLAILFDKQPKFGFENPVPVLNFPKEDFGLRNDVAKLFTEFGIDASLLMSVQRGQFADNFIDIAALNASVVLYDHNKLRENQSNLASRVVGVVDHHFDEQQYTDTAVKLRILRCVGSACTLITELYRECGEDVMCPTLLTAPIILDTVNFEPAQKKVTPEDIAAYEWLHVKESVEGTDAATLFAKLSKWKDDVLGLSVPEILRRDYKQFNFKARTKKGVMSTGTSSVPCTCKQLEGHFSVNMVVEEAAKYMEQHQLDVLVFTFSGQASGKHSREIAFCAKPDTMSVFASFVMEAPSGLSFTKITKCPTADGSYEYTSYSLSDPSISRKKLVPVLSEFLAEGTRSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RGX5</accession>
    <name>A0A088RGX5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclophilin 12, putative</fullName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_010220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="CP009370">
        <property type="protein sequence ID" value="AIN95123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696665.1">
        <property type="nucleotide sequence ID" value="XM_010698363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RGX5"/>
    <dbReference type="GeneID" id="22571751"/>
    <dbReference type="KEGG" id="lpan:LPMP_010220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_010006600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_010220"/>
    <dbReference type="eggNOG" id="KOG0546">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="408413at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000048">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="2">
        <location>
            <begin position="152"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="337" mass="36703" checksum="89A673143C007F54" modified="2014-11-26" version="1">MTGVTSFTVYGLVKAADFQRCAEAAAYVNEKLPESYAVTVTLEAPRDFFERRDAWASVGQLPSQQQPADNSSSRGGEPATTASAASSEPAAVVVVKHGSDGEPQRLLTAEMFLHNIASHTHYRPDATEDYYTAQGQRAWRAFLASRGRQYCWMDVSVSGMAVGRIWFELYTAVAPLTCKNFCELCRGTTVAMGDTVSPNSALDPLPAQQSYHIGYKGTTFFRTLKDAWVMGGDVTGAHSGNGGYSCYGRCFPDETYAVPHDADGILGMCNDGPHTNSSTFYITRRPMSWMNGKYVAFGRVMDGMHVVDAIHAVEVRHNQSPKAEIVITDCDVLDTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHS2</accession>
    <name>A0A088RHS2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peter pan protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_030850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009372">
        <property type="protein sequence ID" value="AIN95320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701028.1">
        <property type="nucleotide sequence ID" value="XM_010702726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHS2"/>
    <dbReference type="GeneID" id="22571951"/>
    <dbReference type="KEGG" id="lpan:LPMP_030850"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_030013200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_030850"/>
    <dbReference type="eggNOG" id="KOG2963">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261452at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045112">
        <property type="entry name" value="PPAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661">
        <property type="entry name" value="PETER PAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661:SF5">
        <property type="entry name" value="SUPPRESSOR OF SWI4 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="25"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="372" mass="42333" checksum="E2F77679093A1F98" modified="2014-11-26" version="1">MVKSAKVNTAMPGKLDTTEADKKTPKSIIIYRGEVGVHVRSLMQEWRNVFLPWSSKKLHGKNKSLKDFLAVAATFSASHLQLFTAPSQGTSLRIMRFFNGPTLSFRVLSFTLHKEIVAKQRRPVSVDRAAWEVAPIVVLNNFTHPDLAHHAEVPLLTATFKALFPSLNVQTIQNCEIQRVCLFHYDHVEHVVEVRHYYVNARTVGVTKTVKKLLESRRPTKLGTLESIDDVLDQEDAWSDTDGEGEEVPLVQPFRQHREQCRVKLQEIGPRMTLQLSKVENGFAGGEVIYHRTEKKTLREVQVNASKVRARKTEKAKRRALQDENVQRKRQQREDKLERKRQRREVAAVAQQANPFEVAGGDSDGYAAGNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RI72</accession>
    <name>A0A088RI72_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LPMP_050530</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Probably involved in the control of the cell cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="AIN95495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703817.1">
        <property type="nucleotide sequence ID" value="XM_010705515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RI72"/>
    <dbReference type="GeneID" id="22572131"/>
    <dbReference type="KEGG" id="lpan:LPMP_050530"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_050010000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_050530"/>
    <dbReference type="eggNOG" id="KOG0594">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07829">
        <property type="entry name" value="STKc_CDK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000574">
        <property type="entry name" value="Cell division related protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000124">
        <property type="entry name" value="Cyclin-dependent kinase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF527">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 2 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="17"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00059987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00064639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AIN95495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="320" mass="36591" checksum="EF83E400D7EE92D7" modified="2014-11-26" version="1">MRSSSPAPARLTGFQRYQRQHKVGEGSYGKVFLCTDVVEGGTVAVKTSQWNSGEEGLSVSSIREVSLLKEIRHPNVVRLLDLFTEEKKLCIVFERMEKDLRSVLSTRQTPIVGRKLKNMMYQLLSALHACHSRRVVHRDIKPGNILVSADEKTVKLADFGMGRAFGLALQSYTYRIATLYYRAPEVLLGDRYYLPSVDMWSMGCVMAELALRRALFRGEGEYSQLITIFGIMGTPNEQVWPGVSRLPHYNAEFPSWVPTSLEKHIPTLDPEGVALLRAMLRYDPQRRITALQAMQHPFFDDVREECEVRLQQQQQQQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIY6</accession>
    <name>A0A088RIY6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleotide cyclase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_090310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN95947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704269.1">
        <property type="nucleotide sequence ID" value="XM_010705967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIY6"/>
    <dbReference type="GeneID" id="22572601"/>
    <dbReference type="KEGG" id="lpan:LPMP_090310"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090008100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_090310"/>
    <dbReference type="eggNOG" id="ENOG502SKFX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272956at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006189">
        <property type="entry name" value="CHASE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50839">
        <property type="entry name" value="CHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="272"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="CHASE" evidence="3">
        <location>
            <begin position="101"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="760"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="761"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN95947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="783" mass="85212" checksum="0EFF7E40713C637F" modified="2014-11-26" version="1">MLVIRRSANARNAALRADEYSTITAWAAVLRAVMIDGLAVARALGGYALSTVPALQPSGNVSVVLSRDNATEYLTRFPRFASLLASQKPAVALQAICPGGVIAMTYPHDAETVGRDLMSPNDPTNQYRPTTLETVLSGRYSIVGPRHTTIASLRRIWVISTRAPLYMRTLNGTPPSLANFWGFVLLIVNVTGALDVIQLDTLAKAKHLNYVIYDLSKNSSSTRVIASSLPPNTTQETYEAFISDSTVMDILAPLSSLYIAVRSRQTYVSLTATNVTIITLWTLFGSLLLLAIAIAAVLWCTRVYDGTKHAPKMAPFAMLTIGPCRGEELWDLAAEQMAEVTDRLDGVLVRQMVRHGAYQIQQVHPLTTSYVTRSVAAAVQMAFSAIEELQRRPIDGPLRAVLGDEGRLLLSYAVHWCTDAAVRVESLDGTYRYEGPDVVFGGRMWAFAAPSVLTASEAVAQALPRHGLSGVVTQAYQMVTVVHATAAKHTDGNDDVEGGIRDATSTNRRSGSMMLYLLAHAAKPNLLAAAAEAVAAAVATVPQLMIDNANSSSPSSYPIMRMNSSSLGAREAVSGLQDGSARPMEAFCPASTTCNLGCTTLRGCRRGRSPLSDGALQAEQKVVVQSRIIVECKTDLSPEQPRVELIEADAVTRALLQPFITRSLDVALRAAFDYQFITLDIRYDEVRVLVYYFYSSYNILFRPLAAPERHNIFRRLVTAFGVPQQGILEHLAARGAMQWLSQVRKINGFMYQQVPLECNSPTTRTPATTSPCGTPPEAKLMHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJ39</accession>
    <name>A0A088RJ39_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_090120</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN95928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704250.1">
        <property type="nucleotide sequence ID" value="XM_010705948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJ39"/>
    <dbReference type="GeneID" id="22572582"/>
    <dbReference type="KEGG" id="lpan:LPMP_090120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090006100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_090120"/>
    <dbReference type="eggNOG" id="ENOG502QSF2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.650:FF:000001">
        <property type="entry name" value="Calmodulin-like protein containing EF hand domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000389">
        <property type="entry name" value="Flagellar pocket-related cytoskeletal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
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        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="173"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="209"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="94"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="273"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="496"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="302"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN95928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="582" mass="65620" checksum="A1AA537C80341F1A" modified="2014-11-26" version="1">MFIVQVAADIFGSKLNFELSFPSRPSVQEITRASESAFSTEIANTRPENVPTHAFHISKIKVYDEDKSKWVDLLGEGQLTDYCQLYAFQPENPWHKETQKPIPPATKPPTASTALSRSAAISNTPSGSRAVASTSNALAPYTGGRSESGSVRRPYAAGASSTALVPRGNADASPEEKLRVVFSEFDNKGTRMIDVEDFKHGFHNMGLDFSSATVEDLFERTDLNHDHRISYSEFERFARLYPIMTDCLYFRSKAFWEEDQMRKEIQAEVEAAHKSESTLDQAQRSLENAEADVADAQSAVKTADDDLRERTDRMRDLARDMEEARKAKERVVREKKDREQDLGAIREREKEARKDLQDLSRDSDKLDRRAAALVNDADAADDKVRQLQKALEDAKRIADRAHQAAELAAVEADQAKERERDAAMEADAIARDIPKAEDAVRMADRNVASADQVLRELDSAGKDIGRQADEAASRRDAGEKAVAEARDKVMQRVRELDAARNAVADKDRVIKQKEAELEEHRRQRELITQHERTLIEQELRLREQRDSLEQRETKLMSEASSYLGSMRINLATRSYSRDPGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJH0</accession>
    <name>A0A088RJH0_LEIPA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_090390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN95955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_010705975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJH0"/>
    <dbReference type="GeneID" id="22572609"/>
    <dbReference type="KEGG" id="lpan:LPMP_090390"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090008900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_090390"/>
    <dbReference type="eggNOG" id="ENOG502S3IB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="256665at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="175" mass="20469" checksum="BFCD5F2BC9653DF6" modified="2014-11-26" version="1">MAFPETLKSGRPAQQNTMSQQLFYANPANAADMARQQQLDWEYTQHMRELHTQRGAADRRFFQRVTDYRDIQDGDPYASVFGESGGTLRLRTAAWQRQFEKENEDVELPYERTNVLSRLAPNWFVRYFVNLRDKGGADHLYFLWACALAAVSLLWFVGYLFYTAPSQARPTREIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJK2</accession>
    <name>A0A088RJK2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Surface antigen-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_040170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="AIN95344.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJK2"/>
    <dbReference type="GeneID" id="22571976"/>
    <dbReference type="KEGG" id="lpan:LPMP_040170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040007400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_040170"/>
    <dbReference type="eggNOG" id="ENOG502SK5W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN95344.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="522" mass="52723" checksum="088BA2722BDCD79B" modified="2026-01-28" version="2">MTPLAPRCCAPALLCAVLVLAAVLVRAESVTVTDDLTMSGASFNDYTMTLGLASSTADVVTVQLMNSQVSGKGLTVQSSGDGLASSARLSMSMLLTTVTQAAITFSGAMPANSDIRIVSTIGSLTSAQSLFDFSGLALDSNVTVTVENTAVTWPKDSINTGSIVLISAGSNAIGIRNLAALFVLDAVATNGASVVRVDAQSSFPVSKAAVLAIDYGRCEECTGALVSINAPLVVDGSSMFRVTNCKAVGASKGLLASAGSTTVSGKSVYLVSDSAVESVSLFSFLTGIEDSSEPYPFTVSGGSTVSFLNLEAPSTGITNQDTLSASADSKVIGGGCVIKGVALNTAEVYKSNGLAVTTVVDRQGASGGTCANAKCIPGNTGAGAAVSGTDPCTCQCSSMDYNPPSCSTIVDPTQNYNPTDVCVVPNCITCDRLSPSTRCTQCATGYILTSDQRCILPTTRPPVCNVPYCTQCVTGSGSRCSTCHYGYTSINGACIANANAAAGAHTVALAAVVCVAAALYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RK46</accession>
    <name>A0A088RK46_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_100800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696803.1">
        <property type="nucleotide sequence ID" value="XM_010698501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RK46"/>
    <dbReference type="GeneID" id="22572817"/>
    <dbReference type="KEGG" id="lpan:LPMP_100800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100014500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_100800"/>
    <dbReference type="eggNOG" id="ENOG502SMI1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267647at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="731"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="875"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1038"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="484"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="746"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="778"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="896"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="913"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="930"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="972"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1039"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1086"/>
            <end position="1104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1176" mass="124075" checksum="B7DA06EA7DD7B6DB" modified="2014-11-26" version="1">MRYAPQTPPPPPAGLNRSEHVEEALSTRLQGSSSAHKTATSDTTPPDPRLGHVMNTSSASSSSSSSKICAEHMQHAAEVAASNRDGLYQAEQKPFVGTSAVALQPPPPLRMRHSTTAPAAATPFPSSSASSTPLGDRAGDGESNHSNNSSSSYSASRTSSHYLFAIQRDLEAIVRLQQLQLQERRVPLPSEASTRESMPGAWIGAKQMAASPLVTDPLHHSTTFVARAAPAIHLQSIDHAKRAWLEGEGTAYATPRQQQQPPQSLPLSCHTHFAGTSASPRTAKVADAAPQLSLDSCRSSVQGVNDMLLSPPRHDTSGASISAGTSIPVMRHQSHQQQPQPPPPPPSSSPIPASLVEYQRYLMQLEHQQRQHREVLRRHRKQHSREEVMAAAQRGGAPITIPISTATPPRQRTGIGTVMEDRRNRSPPLAMMMQAIRQRRGDERGVYSAGILYGCTTSSDSSATVPSAMRQRGRHSQKQRHPMTTSPTAAAAPSRERGGGRRASVRSGHGRSAEDTGPSAARATGAPGVALIDVPARSRYRRSTPQPKQRRDANVRNSATNGIPRHLNPQQPATAVVKEQDGQRLPPHTPPLVVNSLARSLPLVPGPTDTALLQAYADTAALTGPQSSSPVEAFADALLMDVSGALRTGGGGGSAPGPLPAPPPPLMPPTHSVAGTAIKTETTAVTTVGGTETAPPPIIISSSSAVVMPPGDIDEHHQSEAVMAPAVEQKAQHHRSDAQHNAMDRSSNVTTMTTTTPASSAMSSSSSERGASPVKADGGAGRRVKGGGATSATTCPSVGITAVLQHPDTIATAYSGHQQRSHNVVPILVHGNNGFHWRVTRHRSRGAGATVSGAETHHSHPDAHRKYRCHLHNGHHHRSMEGISSTTPEHGTGTPRSSRYRYNSSSTTRQRKQPQQPSKHSPRNASSADTRGDGHDGFIKHPADAARQRPVSPGHGGKAQRRAIPRNSNRDATTAAAAAFNNPPAGIGVVSRSAHSRPPPPTRSAAAVWQDVKLMWAPAPVLQSPFAAVYRYHPHPCLTSSQGQQQQSTTRRGAPPSAVAGTSDESARSHTPGRAVGAGVRERGASRTLTGAAGAAPSLPSASAIRPTQQPQQKASAAIPLLCMTDSLIGAALRDVLPVCRARQREVAREVARRRYQHLPTGIGGGGDVASSATVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RL22</accession>
    <name>A0A088RL22_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_140370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697271.1">
        <property type="nucleotide sequence ID" value="XM_010698969.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22573304"/>
    <dbReference type="KEGG" id="lpan:LPMP_140370"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140008800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_140370"/>
    <dbReference type="eggNOG" id="ENOG502RSIZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267126at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030140">
        <property type="term" value="C:trans-Golgi network transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23211:SF0">
        <property type="entry name" value="TRANS-GOLGI NETWORK INTEGRAL MEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23211">
        <property type="entry name" value="TRANS-GOLGI NETWORK INTEGRAL MEMBRANE PROTEIN TGN38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="595"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="763"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="934"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1331"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1370"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1434"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1510"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1559"/>
            <end position="1626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1652"/>
            <end position="1707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1864"/>
            <end position="1952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2016"/>
            <end position="2109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2127"/>
            <end position="2152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2168"/>
            <end position="2220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2237"/>
            <end position="2258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2285"/>
            <end position="2307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2350"/>
            <end position="2382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="763"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="776"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="998"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1064"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1331"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1465"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1520"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1593"/>
            <end position="1617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1663"/>
            <end position="1675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1689"/>
            <end position="1707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1925"/>
            <end position="1938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1939"/>
            <end position="1948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2054"/>
            <end position="2068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2140"/>
            <end position="2152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2241"/>
            <end position="2252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2350"/>
            <end position="2362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2517" mass="263624" checksum="F095F050032FAC9D" modified="2014-11-26" version="1">MQNVYHRKIDEHFDHIEGYLRRMVRPPRTRCDPLSLNQAPHPAFLLVNATHDDGSSYRTTNEKLGLRGSMAYNVPLSYAGLLSTATNTLAAPPPTRDPTAVRAVAAHYVAPTPPLLPRPLGTPPVLFAGTQPSTSLSKRPPRAQAKAVPPHSTALLSSRTKHTSLSQQETRRLHCRGSSNSSSSSTSSTMFEKGAMSMPNSTTASSALLPAVHSPPPLPLSSLQSAAAAHDQPAAVAIQRRIYDSRSPSLLTYSQDESQGRSMEFILEDLEERLEHSPSLLRSQQQQYFGRHTGSNRHHREGAVHTSSDLVTATSSPTVEDQLSPLHSSLGDSPYPYDTPLSRRLRHFDYLLGDSAVYDDGTSAPQFWYHHNGIQACESACGSNEQRVTRDHDPPTAEASSTERQRHPVDSRAGTGTPSVLPTRHPASTSSVLFADLHSGELRPHQTDPARLKEARPLTFTPRVPSSQHAPVPMLRAAVHSCSAEARTSPPPPPPPAVSHLKWAAAKTLRLDVAAGADTPTPARRDAEDGASHGSRSNDLSLNNSGAGHLALPVELSVDASRMCKSSGASDASEGPLGSEGHRDAHRANATVSQNVGGDVPATQCAFHPTDLHNSPALFSEPQREQSSVRSASTELTALTLASIGGFSVPPSGGSAYMNSEEDVNGGRCLATLLWARRQNTQAAEQLRTLRRRERQHRQSVVKREVEGRYSIRLCEASDAADTGLEGLQGADENTVTATSFTLSSSPSRLVGQLPHLIGDGRRRVTSESLSHESSADGAAAADVSQCGSLGRSGRTLLSSRSNRTVVDGTEQPGTSKRACLVGGEVRASVSPIEIVGGVTVLTSTSEAVAAAAAHLCAALSTAAAEMYNSPAGSPIDAPGVAACEADTPGGTPPPAATTVQVSEEHTLQQEADSHKHGDYAATAGLAAKPTAVAVEDAPPPPPSFDKPSTPHLKGRLSGSTEAAPDTPVDETVQEAVPASPGRTDALSDAHIADTSTSPPPLPPPPEGQSSLPSDFWTLDKGDNEGGSDGDEEAMMAAAEGDRRSGGNEEYAGSTHANGGNGSPGCSISSSTGVFPTRATVTAADDNAQPSSSSGGSKRKRRSTSSASSSSDEFIVRRIPVQVHPSPSTSTGICSTDTERAADGMGHVDAAASAAFTLMPVSSAAEADNTAEHPPVTGTGVEHAQAKADAALVVNLKVERGSDGGVENSRNGAGDDAYEDSLAHSTDAVELVKVLGVREHGVIVDESSKNDEDVPRPSHMVLQPAKPSLPPYATACASTDGPVPASGAATAMTTSSSIVTTTKPLAKGHEARYGTASRSPESAFVTVRPHLGEEQPLPRRNEHAMSSSGASSESFFYSLPDQSVVGAARSDETPEYLQRQADTTGEITSPVARRTEVTPAPYAPYQRSWEQPLIDGDAGPMTTGLSYLGEAWHSSRSPDAGGRIRHDGDAQSYSMRGDACGSTRGSRDLAGEAAHHSTAAPKGPAVSWTIPLDGAGSQDETGYQGLATAQDGARVSVNTSHHHQRTRRRAPHHRLPPHLRPGRPWAHLLTRGLRTVFYSTSSSSRSNESRDGGSRAPAAKHVTGPSEAACGDASSRANSLDASSSSTSSLGAALSAAPRRTGPWYATPARRVKKGHHVVPVDLAKAASWQPRRSVRSGCATHTAEEVRKVEEEARPGAGRQARHALRESASSDATATRSAAARSRTPTTVMYAASGRHRPADFALSPSSVRTRTLADSTAVATYITPERLLQLRQQRQPVGPTYVQLHEQGRALRLRASVVVWRSTTATEAITAGGMRTRQSPSTSSPEGACCGGAASLRSAVVWRLIGAPRPRSTEERCVLQQQGQWESPLVLAPHAVATHRSPVLSQHPPHCLSAPDLRGGVRGNASLSAPPGAVPQEENAAESPGISSAVRAQSPLSLSGTPPSPSTLSVPPPPTVATAPRHTPTSLSMKDAAGVGAENCKLLTVRDSAASTAHSFGLTFDMTPSMYGTPSSTAAATAGGEGVIQDRDEIEQGEENNGENSLGTNSDADSTRPLRVSAPTPPPPQPLLGASRQSTLSDVTPTAASTVVDAQHHDEAKTIQLGPTLPGDTPERSPQSQPLSPAPHALGPLQAALSKEGEAHAAEFVESRTGSGDAAQHLSQQGPAVSFSSDVRNASATGVDVRYQPEASNTPLPQPAQFAPQPAPTVGPTVRTAEPRAVPARPRSDNSRITPLPPEQQRREALECRIARLEVGLQQQQRRAEQPRFRDISDGNGDSVPADNFEAAVDGDEDIVCGAGGGNAELRSHSSQFPQPRGRSRCGSVDGEGRSAVAFNRRKRVASRQVQRGVQPVLQARYQLPASASTIHWAARSRASGSARGTGPIHRRGDLPGAAAPTTPRGGNGIRGGVAVALPAPEAISASAASGASAALYMRLAYRQYGLAATPAVAMPAARGYSHATTSFLIGADWRYQRIYVDTMYFPASAVDSAPQRAEGASGAPEAPANDESERITPAGAVRHAPSANSCNADVFACRALH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RL35</accession>
    <name>A0A088RL35_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amastin-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_140470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697281.1">
        <property type="nucleotide sequence ID" value="XM_010698979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RL35"/>
    <dbReference type="GeneID" id="22573314"/>
    <dbReference type="KEGG" id="lpan:LPMP_140470"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140010000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_140470"/>
    <dbReference type="eggNOG" id="ENOG502SIPV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272145at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009944">
        <property type="entry name" value="Amastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297:SF4">
        <property type="entry name" value="AMASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297">
        <property type="entry name" value="AMASTIN-LIKE SURFACE PROTEIN-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07344">
        <property type="entry name" value="Amastin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="275" mass="30474" checksum="8D71D79ADB971A27" modified="2014-11-26" version="1">MPSELNMNREALTEISSLRTSRRPSSLHRRKSKIGGRTVLYIPYRERMFIALAAVMQVAILALLIAAVVTDIFKVDGTRAIRIGADLRAVSAGLNVSVTEGSRPFCYSLWGARKCGSTSFYTQEWYTARGIADKGFPSPVTLTMMLGAAAFAVLAVCYSLVNIIGIALVVCLQNYTAVLCAWSFSVWITILISWALSVGVYARSILTMNSTTIVGRKVRVRDYCDFSSSFALSMAAFVLHALQFTFTVLYVHMFESRMKSLVTEQKQLSEARLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLD2</accession>
    <name>A0A088RLD2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_151300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697505.1">
        <property type="nucleotide sequence ID" value="XM_010699203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLD2"/>
    <dbReference type="GeneID" id="22573550"/>
    <dbReference type="KEGG" id="lpan:LPMP_151300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150018500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_151300"/>
    <dbReference type="eggNOG" id="ENOG502S43E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272890at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN96852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="33027" checksum="A174927A9E2CDAB5" modified="2014-11-26" version="1">MKPWRVENRFTPVEVQRAFAALRQNVAILHDLSGTSSHPLHPFVHRRGGAGGHQRDHIELPLHHMYEANAVYQQLPVEVRLVCAGLHEAALAYAQEALREPNVSCAARDEILNNLDRKSVLRVLRYPAGSGCRPHVDPGLCTALLVGSAGGLEVSTTDAVPAPFVSRPGDYTSHVASSPTLMHAEHSNVPDTLPHWEPVLTAHSGEVIVMAGNMLRVVSGGALLGVLHRVRQDWVPDTPRAGGQCSPSLSTACIASRATAETNPVSATFRFNIVVELRPAEAKRWYAAMSRWSPLSPVSSPPSMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLH0</accession>
    <name>A0A088RLH0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_160270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN96902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697555.1">
        <property type="nucleotide sequence ID" value="XM_010699253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLH0"/>
    <dbReference type="GeneID" id="22573604"/>
    <dbReference type="KEGG" id="lpan:LPMP_160270"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_160270"/>
    <dbReference type="eggNOG" id="ENOG502QTBQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2498029at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052920">
        <property type="entry name" value="DNA-binding_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43358">
        <property type="entry name" value="ALPHA/BETA-HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43358:SF4">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="139"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="40"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="250"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN96902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="497" mass="56449" checksum="583D1A65C8B97D12" modified="2014-11-26" version="1">MTQVNSAIERLREVSLVSDLPTVIKLIMKRNIDIKRPDADGRTALHYACMNDNRVLVSYLLSRDDIDVDWKDKDGKTALQLTPVEARFEMRLLFSEMMAIQQARERPSSQRGEEANEQMLDDDLRESDKVSPATMRKMVVCLVLPLLVLIFYNGILFAVQFIAGTLCFYYLAVAYFVSEVAIRPPWYHHHPGASALTMKGCPDYWQGWVYNPKRDFGLEYDDVEFPSTDHYTLRGWYVPPPPGRAREMGVVLVHGGGRDRRSWERHLPFLHNAGYGCLLFDFREHGLSSGRMRGFTFGIKERFDVVAACNLMQSKYGYKRICAMGTSVGGSSVIMAAAIDKNIDVVIAENAITTSATLLDQQMVTVLSGYFAQKRYSVVLFRLFRWCATFWLNWRIGNKPSKHCQALHCIAKVSPRPILLMHGMNDTLVPVRHSEILFEAALEPKQLYICEAAFHCGLYNTKPDEYESTVLEFLEKYGVASSPSPSPSPPKEGKKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLJ3</accession>
    <name>A0A088RLJ3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Carbamoyl phosphate synthase arginine-specific large chain</fullName>
            <ecNumber evidence="12">6.3.4.16</ecNumber>
            <ecNumber evidence="3">6.3.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">LPMP_160580</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CarB family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.16" evidence="12"/>
    <dbReference type="EC" id="6.3.5.5" evidence="3"/>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN96932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697585.1">
        <property type="nucleotide sequence ID" value="XM_010699283.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22573635"/>
    <dbReference type="KEGG" id="lpan:LPMP_160580"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_160580"/>
    <dbReference type="eggNOG" id="KOG0370">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="434at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005951">
        <property type="term" value="C:carbamoyl-phosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004087">
        <property type="term" value="F:carbamoyl-phosphate synthase (ammonia) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01423">
        <property type="entry name" value="MGS_CPS_I_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000019">
        <property type="entry name" value="Carbamoyl phosphate synthetase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000026">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000024">
        <property type="entry name" value="Carbamoyl-phosphate synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000361">
        <property type="entry name" value="Putative carbamoyl-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000092">
        <property type="entry name" value="Putative carbamoyl-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.20:FF:000006">
        <property type="entry name" value="Putative carbamoyl-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="entry name" value="Argininosuccinate synthetase, chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="entry name" value="Carbamoyl-phosphate synthase small subunit, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="entry name" value="Carbamoyl-phosphate synthetase, large subunit oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048268">
        <property type="entry name" value="Arginosuc_syn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CPSase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CPSase_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058047">
        <property type="entry name" value="CPSase_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003671">
        <property type="entry name" value="PRK05294.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009455">
        <property type="entry name" value="PRK12815.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009475">
        <property type="entry name" value="PRK12838.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF53">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE [AMMONIA], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20979">
        <property type="entry name" value="Arginosuc_syn_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25596">
        <property type="entry name" value="CPSase_L_D1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="Argininosuccinate synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="Carbamoyl phosphate synthetase, large subunit connection domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="Carbamoyl phosphate synthetase, small subunit N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="10 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 19" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="17">
        <location>
            <begin position="499"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="17">
        <location>
            <begin position="1042"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="18">
        <location>
            <begin position="1301"/>
            <end position="1489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AIN96932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1843" mass="205798" checksum="7634E0341DC351F1" modified="2014-11-26" version="1">MMEHHVKAELVLHGGERFQGYSFGYEESVAGEVVFATGMVGYPESLTDPSYHGQILVLTSPMVGNYGVPPIEEDLFGVTKYFESTNGQVHVSAVVVQEYCDQPDHWEMHETLGQWLRKNKVPGMMMVDTRSIVLKLRDMGTALGKMIVAGNDVPFMDPNTRNLVAEVSTKTRVTHGHGTLRILVIDMGVKLNTLRCLLKHDVTLIVVPHDWDITTEVYDGLFITNGPGNPQMCASTIRSVRWALQQDKPVFGICMGNQMLCLAAGGSTYKMKYGHRGQNQPCKCTLDGRVVITTQNHGFAVDFKTLPLDEWEEYFINSNDGSNEGLWHKTKPFCSVQFHPEGRCGPQDTEYLFGEYVRRVKESKVKEVAKLKPRKVLVLGAGGIVIAQAGEFDYSGSQCLKSLREEGIETVLINPNIATVQTDDEMADHIYFVPLTLEAVERVIEKERPDGILLGWGGQTALNCGVKLDELGILKKYNVQVLGTPVSVIAVTEDRELFRDTLLQINEQVAKSAAVTSVEEAVVASKEIGFPMMVRAAYCLGGQGSGIVENIEDLRHKVEVALAASPQVLLEESVAGWKEIEYEVVRDIYDNCITVCNMENFDPMGIHTGESIVVAPSQTLSNDEFHMLRSASIKIIRHLGIVGECNIQYGLDPFSHRYVVIEVNARLSRSSALASKATGYPLAHVAAKVALGKGLFEVMNGVTKTTMACFEPSMDYIVVKMPRWDLDKFNMVSEDIGSMMKSVGEVMSIGRTFEEALQKAIRMVDPSYTGFSVPVRFNGLDFDYMAHVRRPTPYRLFALCRALLDGHSAEELYRMTRITRFFLYKLEKLVCLSKATSTLYANKLSEIPREYLLNMKAHGFSDRQLAQFLSTTAADVRARRVELNVMPLIKQIDTVAGEYPAAQCCYLYSTYNAQRDDVPFTERMYAVLGCGVYRIGNSVEFDYGGVLVARELRRLGNKVILINYNPETVSTDYDECDRLYFDEVSEETVLDILTKERVRGVVISLGGQIVQNMALSLKQSGVPILGTDPANIDMAEDRSKFSKMCDDLGVPQPEWISATSVAQVLEFCDTVGYPALVRPSYVLSGSAMAVIANKEDVTRYLKEASFVSGDHPVVVSKYYEGAMEYDVDIVAHHGRVLCYAICEHVENAGVHSGDATMFLPPQNTDKDTMKRIYDSVNCIAEKLDVVGPMNVQFLLTVEGQLRVIEANVRSSRSVPFVSKTLGISFPAVMVSAFLARKDQNLVPIKRAKMTHIGCKASVFSFNRLAGADPILGVEMASTGEIGVFGRDKHEVFLKAMLCQNFKIPEKGIFFSSDVDSQTEVLCPYIQRLVRRGLKVYCTANTANVLQEYGILCEVLLQRSELPSGDASDSRCLAVYDEEVAKKEKFDLVIQIRDKKRDFVLRRCTRETASPDYWVRRLAVDYNIPLLTEPSIVKMFCECMDLPPSSIEIEPFRHYVPKIYHKIENNNCAMLRRHKVGLMITNNNDSKILALRLSQEGLNITCFHAYLGGSDIDNFEQAFQSLNVPVEVVDLRSEIANSAFDLIMCQSADERHNWHLSKLSWYIFGKYLIPVMRARHMSVVAQTSKQNKKEAGFEKHVQNNCPEMGVYNAWRDARLMEDFATVADQISFLRKQGIKATVKSNIQVHSSVCGNTYYCDDMRSLPAPSLVKLLRDCSATPEFVSLTFRSARCVNINGIDATPLLALQMANEIAGRNGVGITRTREGAMFEAPGMHLLSVSLQFLYDVSFDRSAADLFRIYSRHVSQNIGAGQLSEKHTQSAIEAVRFLTSDVSGVVELELHQGEIIFLKLSHVQNPVNRHAAPQLVTEEELEEVFQPGNGSFSDVQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLN9</accession>
    <name>A0A088RLN9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_141220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697353.1">
        <property type="nucleotide sequence ID" value="XM_010699051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLN9"/>
    <dbReference type="GeneID" id="22573389"/>
    <dbReference type="KEGG" id="lpan:LPMP_141220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140017800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_141220"/>
    <dbReference type="eggNOG" id="ENOG502S3HN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273283at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="286" mass="29733" checksum="9E2E7AE08D0EBF90" modified="2014-11-26" version="1">MSQEEAEPRFDFNEGTGAALGSLPCFTAVSTRGAAGKALEAALEPLHRIAYGRAGSSGKRRAALASFKGCPMSMEAEVSEKIAKLTKDRLRDVIKALGINVHISLSHAEVAAGVAQFLMAPRDDGKFKHSGSAAAKSKTSPAKRPASVNPDDEPLTKKLHQELPASLSAVEASATKVPAASAVPSDDAVLVEVYRRVLAMTPEDRAVLGVKALRTSLEQHFKLAAGGLRHKKGIITTAASDCVRALKEAEMRAAAAAVQRIGDAPASSTPEASDSTAQVPVPSPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLR8</accession>
    <name>A0A088RLR8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase, putative</fullName>
            <ecNumber evidence="2">6.3.5.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_161320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.5.-" evidence="2"/>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN97007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697660.1">
        <property type="nucleotide sequence ID" value="XM_010699358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLR8"/>
    <dbReference type="GeneID" id="22573711"/>
    <dbReference type="KEGG" id="lpan:LPMP_161320"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160018500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_161320"/>
    <dbReference type="eggNOG" id="KOG1212">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="566138at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052739">
        <property type="entry name" value="FAAH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43372">
        <property type="entry name" value="FATTY-ACID AMIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43372:SF4">
        <property type="entry name" value="FATTY-ACID AMIDE HYDROLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="86"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="599" mass="66129" checksum="569F5E915AE15EC2" modified="2014-11-26" version="1">MNLLKIFLALAIAAGAVLTYHFAYFLGLITYGVAVCGVCNWWMSAFMQAGPRTSRQIPQHPIAYCQQLSALELSKAYREGRLSCVEVVSTFIEHIKSVNPYMNALVFDCFDEAMKAAVEADRVWSAWREHKDPKRIPSWLLGVPCTIKESMKCRGCPNTAGNPKRRRITSEVDSPVVKNFRDAGAIILGVTNTSELCMWYESSNYMYGITSNPYDTRCLVGGSSGGEGAAAGAAFSTFSLGSDIGGSIRMPAFFNGVYGHKASPHYITNIGQFPAAKTSANHYMTTGPISRFPEDLIPLSQIAARGGFRLDPVVYPPCSPLKKVLDLHHHPLRVYALEDYGLSFIRVSESQIEAVHAAAEALRERYCAKVTYINVRTPSRSTGGVVPPEFQPFANTLSMWASALTKDPTESKFSLCMSQGHMGSISWWAEVVRWLFGRSHHTLPAIVLCTLETLDLALPQWLKAKREEGLLPFKVGLESLLGVDGIIIAPTFPSAAPRHHFPLWSPFQFQYTAVFNVLQLPATACPVWPGAFMANRRKSVSIHEKRCQQLPPDFHLPKGVQVVSATDQDELCISVAIALKDALGGYRYPSWAMLEGTDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLY1</accession>
    <name>A0A088RLY1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_151180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697493.1">
        <property type="nucleotide sequence ID" value="XM_010699191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLY1"/>
    <dbReference type="GeneID" id="22573538"/>
    <dbReference type="KEGG" id="lpan:LPMP_151180"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150017100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_151180"/>
    <dbReference type="eggNOG" id="ENOG502RD8A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="441812at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053201">
        <property type="entry name" value="Flavunoidine_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12350">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12350:SF5">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="129"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="348"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="391" mass="43874" checksum="BA436514B2F976FC" modified="2014-11-26" version="1">MLQRTAVSRCFGKALYGPSSTLPGDFFHCCAAHFKVHLHEETFIGTRSSQLRGLFLSHSRTTPLPANKPLATIPLSALLTVSNMATMPNGLPHITLAKVRDAIADDEFRIMAPQFYLGLQMSAIIAAIPDITRVRSAVEVSQAAQILSAGATPYARMLDDEDFNEEFVFGMYGMALDSWQRASYEEMTKKYHLALTAIHETFNLPFKIEHLQRITRLVLARVEHVPPSDYYGGSLFLRRLQRRWRRLKKIPEPAEVALVPYLDLVNHSNRPNCAIRIGPSSVLGGEGAITLVTLRDVLPGQELCRHYNFALNRASALFRYGFLPFDLISIVDHDAVDEHVRKSRDMFRPKSEEQLEQQRQEAKEVARLEKLFQAAKQRRGDSGAGVSASSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLZ0</accession>
    <name>A0A088RLZ0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Biopterin transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_101250</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696847.1">
        <property type="nucleotide sequence ID" value="XM_010698545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLZ0"/>
    <dbReference type="GeneID" id="22572862"/>
    <dbReference type="KEGG" id="lpan:LPMP_101250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100019800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_101250"/>
    <dbReference type="eggNOG" id="ENOG502QRK9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="256822at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039309">
        <property type="entry name" value="BT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004324">
        <property type="entry name" value="FBT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00788">
        <property type="entry name" value="fbt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585">
        <property type="entry name" value="FOLATE-BIOPTERIN TRANSPORTER 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585:SF51">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03092">
        <property type="entry name" value="BT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="476"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="506"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="545"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="586"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN96194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="656" mass="71718" checksum="B050F441B7A9C49A" modified="2014-11-26" version="1">MPDDQQTGNVVNGGDVPCSAPPQQKLEEDDEGYVHPDTATLFDAFPFMRHFPIFGTAVVPFGPKCTMSLGVVYILSKGLARTLLNASRYAMFMKKYGVTTAVYQRISGIGSMGFSIKPLTAILSDTFAFFGYTKRWYMAVSCVAGAVCAVVYGLLPFKSSSAGIAGGMIFISVFCIANIDVLSEGHYSRLIKRHPVPGADLISWIWALIMVGAIIASAIQGPLSDLGRPTVGIFISAGLQAFCMLFFIFNWYGEKKNLVERKEDYLFLLKEAQMRGTDSEPIKEGVLGYDSTTNKSKSAAPYPEPFAQNGGNELVSCVELDHDEIECDFVATTCMCGIFGVNKEVIFRNVSIAVYGVIMTAGVIALTVLNITGSTYELLYGCIGISLILCVTGFLCIPITIMKANFFGWFQQVSYILISGGTDNFYMSDAACLPDGPHFTQTFYNTVGSVIGNAAGLIGVYMFARVFSKQSYRVTLACTILVQVLASVFDIIMVQRWNLYIGIPDHAMYIMGDAIVYEVCYMLNYMPLNMLISRLCPKGCESTMFAILASFSNMGSSTSSTIGAILMETVWPLSSSPPCDFSNLRWLLIVGHLITPLIAIPAVFVLIPGTRICDPIDPRDVEAQSIFQTWLNKFTATSDTHAKPQCKSLPDSEEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RM22</accession>
    <name>A0A088RM22_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_110430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696892.1">
        <property type="nucleotide sequence ID" value="XM_010698590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RM22"/>
    <dbReference type="GeneID" id="22572908"/>
    <dbReference type="KEGG" id="lpan:LPMP_110430"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_110006700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_110430"/>
    <dbReference type="eggNOG" id="ENOG502RUF7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272028at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="609"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="643" mass="70825" checksum="8C2A895267DE93B4" modified="2014-11-26" version="1">MAHVLQKCAHELGISLNATGVYYTKGKLPSRATTSIDGAPLAASIGGSVGKAGKSNSDGTVKEGQTATMKANTDGGDVPRAAARTPLPLTSADMNAAVPEGTSSNSKKVGPVDFFFDVCLHEIPNPPRDFDVTPSALVVDGTHSSANGAVIAVRDFVSHIPSFFVPVTEVVANMPGYTAEHLEVYLNVKPLELVTVAGERYVRLYGSFGDLSLSGTEVSEKLYARYRPNVALVATLEAAFEGIYDKWMPLPELLRRVGPNVAAQLPYQGPAAITYFAQMQHRFAFAVRNVPIMGDSADGVPSSPKFTTEAAVLLRMPGYSNLDAGSTPTPKSFQVLMGLVPGDKQVDIDVVRGQLTSEVRAELNSYYNGLEGFFAAHKPVFFVPPEIPTVVMRMRYRLRTQRAKLPLEEQLRIATDARDKPRVRALRRKIAFRDDPSHPLHDPENLAKEVSKHLPHHGFVSLKSFLKRNLPEELLMYMPRRIRSFFNNYPQYFTQFEYQSPGTWCLCRPDQPLPRGVIRQNFSDGDLLRLIAEFLQQRGARAASAVHMNLPFGAQEVIRRRYGGVYFFVIRYPQYFNVVLKTDRQNVKSSAVVHLIQVPTQELSDATMAASATSWNNPNAPSHGGDDHEGGDSYDDEDLDGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RM43</accession>
    <name>A0A088RM43_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_160410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN96915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697568.1">
        <property type="nucleotide sequence ID" value="XM_010699266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RM43"/>
    <dbReference type="GeneID" id="22573618"/>
    <dbReference type="KEGG" id="lpan:LPMP_160410"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160008300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_160410"/>
    <dbReference type="eggNOG" id="ENOG502SISR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="261310at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="39103" checksum="AF0B0B64435DEE4D" modified="2014-11-26" version="1">MAPPSSFLWFVLRRLRYAVLFSIALLVLLYAISSMYYVVRVSVIQNPTPFVQIERDTDGPTQPLMSPAVPMSKDTAASLSVAEGGEATLRSARHCNSNPPYTHMYKVLRPGTPMIKQCLRNPTLPADVPLCSNDAGHASAERCGGLCDAVPLRQRYVLDKLQLGMSYMIRLSFLGPPSVGFDLVLYQVRRSSVVRFVEGNDDVAGVPSPRVRGWAEEPQDTELLVFVTSRDNALEFSMEENVWVDRADIDSTASDSNFDATTMHGVIRAASDTNDPFVPVVEVQPRALSIPVDAYRLPLVCFNMELEQLGSFFLPSMAVPLAAYVVWALVFVGYLGIYTFVSSGIAGGEGAKQHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RM83</accession>
    <name>A0A088RM83_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_160860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN96960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697613.1">
        <property type="nucleotide sequence ID" value="XM_010699311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RM83"/>
    <dbReference type="GeneID" id="22573664"/>
    <dbReference type="KEGG" id="lpan:LPMP_160860"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160012900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_160860"/>
    <dbReference type="eggNOG" id="ENOG502SICV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="261212at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="298" mass="32680" checksum="5E5F0E7783818DE2" modified="2014-11-26" version="1">MSQNMLAETVPLFGAAGRRSYDVFPTAAQRRHPFIMAIGSSCNVQRATDGTTYPFISALAPSVCPRSRAYSAATVHQQPLPSRSAGPRRSNERRCGGSRRLSWNTHFSQLLSEEQITRWRLRCKEQEERVEIALAKPSCWVLFSDAHTTAAHSSRERGSACLSCGAYSRPRLPRSEPVCAMVDEVHSLGAGRRRIKTKKHCSSGRSGDFQEQPSSGTRDAASATAPLHVRDSELLRALQRAEARIKQLETGIVPQTPALGEEESVMSASSSTIVRPQASTRPGPIHPYTPLSPYLVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMG6</accession>
    <name>A0A088RMG6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tubulin--tyrosine ligase-like protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_180360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tubulin--tyrosine ligase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697870.1">
        <property type="nucleotide sequence ID" value="XM_010699568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMG6"/>
    <dbReference type="GeneID" id="22573926"/>
    <dbReference type="KEGG" id="lpan:LPMP_180360"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180008600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_180360"/>
    <dbReference type="eggNOG" id="KOG2157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070740">
        <property type="term" value="F:tubulin-glutamic acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241:SF39">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE TTLL9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="143"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN97217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="441" mass="49739" checksum="FC1AD54FCD43EE5D" modified="2014-11-26" version="1">MRCRGWIETDSELDWDYYWADVSWIRENYDGLRLDDHQRLNHFRNHYELTRKDTMVRNIKKMVKALEKDGDAEEVAAAWDFFPATFSLPQDYGLFEQEFRRHPNTIWIMKPPAKAQGKGIFLFSKLSQISEWRREFKQRHGYLTSSGGGGGSGGPMGGGGGNGASSGGGGGSGNPYSGGTMGNPYGVSEAVEPYLAQRYIANPHLVGGKKYDLRIYVLVQSYQPLTVWLHRTGFARFCHHRYSLDDIDNTYIHVTNVAVQKTYPKYTAAASGCKFGIRNLRTILTATHGAARTNQLFGDIQQMIMRTLFAVQRIMLQDKHCSELYGYDVMIDDTLHPWLIETNASPSLTAETPADYHLKFNMLQDMLDVIDMEGRRSGEEERVGGFDLIWANGPAGVSTNNSQKTMISSYLGCANELEIPMSQLRLPPRLQNHNSSEHPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMH2</accession>
    <name>A0A088RMH2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">N-ethylmaleimide reductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_120820</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009381">
        <property type="protein sequence ID" value="AIN96409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697062.1">
        <property type="nucleotide sequence ID" value="XM_010698760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMH2"/>
    <dbReference type="GeneID" id="22573088"/>
    <dbReference type="KEGG" id="lpan:LPMP_120820"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_120012800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_120820"/>
    <dbReference type="eggNOG" id="KOG0134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1663137at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000059">
        <property type="entry name" value="N-ethylmaleimide reductase, FMN-linked"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="5">
        <location>
            <begin position="12"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="5">
        <location>
            <begin position="420"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="821"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="838"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN96409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="889" mass="95551" checksum="6058964EA64F74A6" modified="2014-11-26" version="1">MSAGNRTVYSHLFRPCRVGQPTMKNRMVMAPLTRCRADDNHVPTAIMAEYYGSRASMGMIITESIMVQRNYSGFAYEPGLYSAEQVESWRTITEAVHARGGLIAAQLYHPGRATTPANLTSGDLAPMGPSAVGIPPEAEQCIAQWSRDGKAQAYPQLIHAMTLAEIGAAVKFFTRAALNAMAAGFDAVEIHAGGGYLLDSFLRDSSNQRTDKYGGSVANRSRFLLEVLDAVAAAIKPDRVGVRLTPLDTFNGQKDSHPEALTAYVCEQLDARKIAFVDVVRGDPRANVPGSAEVWVRRSFGGAVLASHGYTSLEMAEQAIADGTVDAVLFGMQALANPDLVWRVLTNTPLNRAHAPTFFTRGSKGYIDYPICEPHSFSEPHVVAGITIPSEGSKGSRLSCQRATAMPMPAKGRPYVSVSQPLLLGATTMKNRLVMGPIPRQRCDEQQCPTAMMVAYYARRASYGLIISEPCEVQPGYHTYVRGAGISTKAQVLAWRQVTDAVHEKGGIMYCQLHHGGRATLQCNIASGTDTRAVGPTMQGISPDCRCPAAFAADGKVQSYPVDVVALSAERLKWIVQLYVAAAKNAMLAGFDGVEVHAGGGYLIDQFLRRCSNTRNDDYGGSPADRCRLLDEIVDAVAAAVGRRRVGVRISPTDLSKGMKDTDREVVTETVATHMGERKIAYITVASGSDGYYHGPMPASLLQTALRCFGGVVLCDDNISLAEAEKRIATDAVQGVCITLGAIANPDIINRAIHGAEPDESDLCTLFTHNSDGYDSYLTYAEMRKEARVGKARQSAENSAGHPPAMLNGVTCVAADKDSATLNSPTTHKSHGAVKSASRGTKSTPPTQDTGSRRVSTAAHSVSAEFNRGPQALLRPDNRAIRRHSVTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMI5</accession>
    <name>A0A088RMI5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C-CAP/cofactor C-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_180610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TBCC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697895.1">
        <property type="nucleotide sequence ID" value="XM_010699593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMI5"/>
    <dbReference type="GeneID" id="22573951"/>
    <dbReference type="KEGG" id="lpan:LPMP_180610"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180009200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_180610"/>
    <dbReference type="eggNOG" id="KOG2512">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="194775at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990075">
        <property type="term" value="C:periciliary membrane compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006599">
        <property type="entry name" value="CARP_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012945">
        <property type="entry name" value="Tubulin-bd_cofactor_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039093">
        <property type="entry name" value="XRP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15440:SF0">
        <property type="entry name" value="PROTEIN XRP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15440">
        <property type="entry name" value="XRP2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07986">
        <property type="entry name" value="TBCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00673">
        <property type="entry name" value="CARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="4">
        <location>
            <begin position="162"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="137"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="405"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="492"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="429"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="493"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN97242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="522" mass="56492" checksum="682C23072CFFA8FB" modified="2014-11-26" version="1">MASSTLVETERIIREKLEASGQYGKMRAMIMEAALQTVSTGGNNNSGVHQPLVFHPTVALRDAKQNGVTELSIVQEYLQYLGLQYTARVLQLEAGLQEVALRTSAELQEQLHIAVDDRSDPCLSALVHGRVTGVVPSTAATGTPAAAAEEEDTNTEDIDDTASDHNQPGGENTTYFISKWKKRHFMRHNQVSGQQVQIEYLTDCHTAVLDELDSMTVDDCEGGELVIAACEGSVFLRNCKNMTIHVACKQLRTRDCEHIKLYIFTSTDPVVEMSHHISFYPFHLRLPGLRRLFAEARLDPKANRFVHVYDFTPTEPQLPKPHFDVHFPDHHLSMEDRYASYGALDCPPEIEELLALRLMPAASSESGKNKSYDIRTGAQMWAQAGPTPAPAVAAAAAAVGTAATTSANAHAESGDDDDEEEIASDSDHSGSSPQSTSASTASSSEAEEYAPAERQIAGQSAMQRIGGLSAAAPLGPIPAVGLAAHAVTSGGIDNEEYSSFDDDDNSNDADDKCNVDEDEDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMT5</accession>
    <name>A0A088RMT5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_131210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697202.1">
        <property type="nucleotide sequence ID" value="XM_010698900.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22573231"/>
    <dbReference type="KEGG" id="lpan:LPMP_131210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130016900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_131210"/>
    <dbReference type="eggNOG" id="ENOG502QS2I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="77911at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="447"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="492"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="937"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="976"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1060"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1214"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="786"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="501"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1219"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1250"/>
            <end position="1261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1297" mass="136429" checksum="9F8F087ACB554B93" modified="2014-11-26" version="1">MNRWALFSSDNDDDVADVVSVAGAGAGDRGMSGALGPLLALDTVSTGRASQRYSSSVDRDRMNTAAVQLPESSKVTATRRNLSQLFGAGPTPLTTPTEASFPSQPSAMENTAARNLTNGAAVVTGSGATEIPAFFAPRFDYEGSSSTGAASGVAAAVVAATGEAAAGLITAEHAVVQAYRDSLYSGTCILALCVPSAPTSVVTTSAASPPSVALRRHLLREKQGAGAASNVAACGPTLLLVSSNRQVLCRVALDATDGVFASDSLQLRQDAAQPQYLTFFDAGCTGARRKSSSQRSAGGGGSSRCWWTCMFPDRDKASRFLVSIYTVAQYAAVLANREGTTSAPVSSVRTLPAPPLSKTNKAEAAAMGGAPDVVRPDVPATICWQTWALCRVSQQSLYCLPGSCIESVLPSTPRAVAATDGTLWDAAAAALVGMQAGESRLVFLTPEETRMRQPTSRADSHRSDRPGRGALQRPLDTPAVMYMTCLEVTSSPIGAPRPSTPAAASDLAPLLPHPTPPAPATATAGEQPPLAAAPSQVPGTANAQSTDVLLQQLLLHLLQQQPHEPLPNAHTSHQGPSHGWGDMERALTRVQVQLGSLYEKIDRLDIEAKLQHNNTELERVMRRVVGLAPQEEVAVEDSLKDREKLLASIELYRHKYEEANASYQRALEAMGRSSDRAQALEKDLHLQQDLWAQQRKEEAEQMRLRLVERDVRHREELERVSMERYAAGRSDGHAAGYREGRQATLLEVEDSGANGGGGSVVAQWRAKLMAQSQEVIALQTALQDAKLRHERDRRQLRAEIDVLSELNEKLQHLQVNADVRVPEETAQQQCKRVKRTLNAVYSQVEGQLLQLSSLQRRARAGDPQSSRTVDEGAYVEGAREAWSTDGSGSGDLVAMDDVLAIIMEAIRSEAQTVVAQIRSDEAQRTTKNAELRALTVARRSGQQPSPASSHGYPPSASSALLVRYGVEEEVRGPWVEHSTAEKHASTTPPPSPLPPVHTTASQDALAAVAAALLPKVAQAASMKASAAEAAEVTYRGDGRVCEDTAVNQAAVSPVTVEEPLCSETGATGGGGENGDADPVARQSCNAPTHTDLDATAASSAVSSSAYERRVEFADVGDGEALRSNVADNTDGHHAFSSSVLAAADDAAAAWAPGGLCSSPGIAEKAQPVPTSHPTVATTATTSSAPTWVGVDSPCMMHRAHDTLEEVRAVDIASAHTSRHSGTSLSSSSSSSTSAKSSRMATRLSGDARASPPPPPFVPPPGNEDDDGGHHGGEAIGDSPSGSMTAPGCTHEPWTGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMV7</accession>
    <name>A0A088RMV7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Abnormal spindle-like microcephaly-associated protein ASH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_180570</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697891.1">
        <property type="nucleotide sequence ID" value="XM_010699589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMV7"/>
    <dbReference type="GeneID" id="22573947"/>
    <dbReference type="KEGG" id="lpan:LPMP_180570"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180009600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_180570"/>
    <dbReference type="eggNOG" id="ENOG502QPUP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="545169at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053879">
        <property type="entry name" value="HYDIN_VesB_CFA65-like_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056307">
        <property type="entry name" value="Ig-CFAP74_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22538">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22538:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22544">
        <property type="entry name" value="HYDIN_VesB_CFA65-like_Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24778">
        <property type="entry name" value="Ig-CFAP74_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24771">
        <property type="entry name" value="Ig_CFAP74_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CFAP74 third Ig-like" evidence="7">
        <location>
            <begin position="283"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="HYDIN/VesB/CFA65-like Ig-like" evidence="6">
        <location>
            <begin position="694"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN97238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1066" mass="117527" checksum="020FBA4F362555C4" modified="2014-11-26" version="1">MDFLSFDNGVIKNPFYWKDADDGDCNYSTHRKWRRQPRDAINSARAVYTRYLLSKEKTPFQFNPETVCFADYDVGKEHKMLVTFTNTATVPKTFRVMPIPSRYANMVSIEYTVPPKISPGLSWNIIVKYRPGDLSDISTAIYVKTDEGYFAVPLTSSKKAFAFSVEPKDVNFGTVIVGEKRAKTIRLHNSGAMPGTVILGGDFKSLLEQRSEHPIDGQKMSLFRISPQQYRIEIPPFSMSQIVISFAPLYPMQISSEITFTEKDNSQLAHTTSITGSSTDLPVFLTTGKLEFGACFYGERYWDEVSIVNKSNIAAVAEFQVPVPLLGALAVFPSRVCVQSGEEYSVRVAFTPSKDLPKDFFSMIKCIVRDQTLPLILNIDGVLSHRAPRLPLTAFDIGTIPLQTMQSVQVPVTNESSVKQLVGFENLPYWVAATPDVLELVPFETASFTLKMEAPQEGRFSQTIKLTNEFGDTQCIALSGQGTRPAAALSARTLLLPPCNIGHSVSATTVLSNTNGKLIQFSFLVPCSFFKVSPNAGILQPGESVVVAIFFHAPMEFEYVDPLQLAAPAQRSSRPKKDPLNGIISEASAPQKHAMYNDWEQGSEKEIWSKHRQFRIQCCLSGSDDECCFIVVRCCAVMSPVRIEEVGNAPGTLPGKQQKPTDIDIRQGFAKASVVADKDENGAASQSYKGEVFMDFGKVPIHHASIRMFKVRNTGSAPCMIRAPPLNPFSSFLVVSVTFDEVPPHTEAEIPLSFHPHTYGNFNETIKVELVMLDGTVVFAAVNVQGTCTPTQLSITPAESVSQQDAASAASVRYIAFDCTQKGESTRTSLSFHNVGSFPLDILIRSHTEEDEGVHAGSNAVHFDPRDTRPFLVHPWAFTIQPNTRQVVDVVFAPLDAGVHSKRLSIAASGENRELVLEGRSVSSSFYCCVPISDVRTGKPTAISFEGGIGCRPDYPVTLLFAEEESKTLILGNLFKGLSVEYEVHNWEQSRLLEMHPGWSVAPLSQMIASGKEARLSVQRSFPEDEEAEGMACSSNSLFPFRFTIILRGAGAGMLPYRALYVVCAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RN99</accession>
    <name>A0A088RN99_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_141010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697332.1">
        <property type="nucleotide sequence ID" value="XM_010699030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RN99"/>
    <dbReference type="GeneID" id="22573368"/>
    <dbReference type="KEGG" id="lpan:LPMP_141010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140015500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_141010"/>
    <dbReference type="eggNOG" id="KOG4580">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2243669at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="6">
        <location>
            <begin position="61"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN96679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="180" mass="20147" checksum="0816871F687AB4D7" modified="2014-11-26" version="1">MDTTNRGLSYLCCVDGSLKPWAEGQDEGDDKYESLQGPGGRNLTGSVNDKRICVPQKIDPKTFFANERTFLKWLSISVMVGLMSLTLLNFGDSTNNGAELAGLVLLPVSIVFMVYSLFIFRDRANKIYMREPMRYDDTRGPTMLVLVLGSALTLATLFSLQRQYTQTVASSFWESARFSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNG8</accession>
    <name>A0A088RNG8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Choline/Carnitine o-acyltransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_191420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698136.1">
        <property type="nucleotide sequence ID" value="XM_010699834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNG8"/>
    <dbReference type="GeneID" id="22574196"/>
    <dbReference type="KEGG" id="lpan:LPMP_191420"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190021500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_191420"/>
    <dbReference type="eggNOG" id="KOG3716">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004095">
        <property type="term" value="F:carnitine O-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF31">
        <property type="entry name" value="CARNITINE O-PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="6">
        <location>
            <begin position="196"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN97483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="865" mass="97247" checksum="FD826CFB814B3B11" modified="2014-11-26" version="1">MSEAFLSQQPHPVNQTRDAGSSVMQMRVSWTSNGLDVHVPPIRYIWRGMHRSIMDNIDKVSAMVYPIPFSCVVACAAGSCVWVWYVPQTSWVHTNPASTWLRYFDSIVSPLSRHLPPTLQAPVLCAKAWAVTLAAATVLHRFALRRLLQYKGWMLERNPQMPSWRTRLWSLVVRAFFTRPSIPKTRVYGRCLPSIPLPSLQQTVNGYLSGMRAIYHQSDSDVNEWLELRRSAESFLLNEGPSLQMHLRLQHVMGHNYVSELWTRNVFLAARDSLCLHSNFYTVPFATHLPTTLPEARAAVLIYLLTQLKGRIECRTLCPNFTGPRHCVPLSMDQYSMAFNTTRIPGREVDILEHHGERENGYLIILHRGRIYQMPVMDPQTGRQLTPHQLEVVLHQLLVEVEEEVSTGRDESEEDDAEDTLETLGKKRTYRLVEALLPALTTAPRAQWADVRNSYLLHDSNNNSPLRVIEKAIFVVSFDERCGTTGTSKASLAVEDVKRLSMDCIHYLCGTGSNLWCDKSFNLVVRSDGQVGLHVEHSWSDMSTFLGFFEHVSAQEEAAELWYDTKTGHAKKLPEDKRRAKPFRAPDVDSPLCPKRLRFTIHKRLAAAIRQAHTEFLFNLSSQVDLHVVRYSRYGREIPKSLGCSPDAWVQMAIQLAHYIDQGGHISLVYESVPQNMFAKGRTEAVRSVTDVSTAFVKAMAATGGEDDTMSAEVKRALLVDACANHQRSVQEAVAGGGVDRHLFALFMASASQGTPSDFLTAALRKTKWKVSSAQAQQRNLLDRLHTADGGNWYHETPGFGFGPVSLDGYGVSYCFCANEVLYVTITCYKNCDTTSSRALGNHITRALNMLGELSASPRDASAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNK5</accession>
    <name>A0A088RNK5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-specific glutamate dehydrogenase</fullName>
            <ecNumber evidence="4">1.4.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">GDH</name>
        <name evidence="6" type="ORF">LPMP_151020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">NAD(+)-dependent glutamate dehydrogenase which degrades glutamate to ammonia and alpha-ketoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-glutamate + NAD(+) + H2O = 2-oxoglutarate + NH4(+) + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15133"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.4.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.2" evidence="4"/>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697477.1">
        <property type="nucleotide sequence ID" value="XM_010699175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNK5"/>
    <dbReference type="GeneID" id="22573522"/>
    <dbReference type="KEGG" id="lpan:LPMP_151020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150015400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_151020"/>
    <dbReference type="eggNOG" id="KOG2250">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="184415at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016210">
        <property type="entry name" value="NAD-GDH_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606">
        <property type="entry name" value="GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606:SF24">
        <property type="entry name" value="NAD-SPECIFIC GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000184">
        <property type="entry name" value="GDH_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="5">
        <location>
            <begin position="633"/>
            <end position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN96824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1020" mass="115149" checksum="A32401C97BFADF31" modified="2014-11-26" version="1">MMRHTVSQAMASLRGRVLPTSHAIAAVALLGAPSLANPCRFASSATALPLVDRDAIIKAVTTKAVFDKKIVESLTNTFVSGLEKSSYTRNFSQAEMIDHVQGLLTAEARFRMGDSFEYVHENQRTAFYICYNEPQKKLRMLRKMAQFVSLNEDPNLGSNTHHYVSEDRKFAIYTASTEAFIENWGEEEHVNPKNPALPTQTAFRQLTEEQKEIIRGLLRRQLSSVFPLFHVEEVKKGHVSFTMATMVERTNYVASLLSIFQEIAGAEVMTSVSYSFSNGVQVYGFEIQGATAEQIEERASLVGLLPNRPFKALTCLHEAGALSCEETVFIDAAVIFAMYFTPSPTTDDYRHLKTILAKEPNGVNRLNNLRGSLTQEVMSERYTGSVIALYPEFAKLIYDDFRLGSTPERRAAIAEKITHRLREDDRPEYDRTLFMSFLKFNEVIIKHNFCKTEKAALAFRLDPTFLKELEFPRVPHGVFLFAGGQWRGFHIRFTDIARGGVRMIICKERDYRKNKRSVFQENYNLAHTQLLKNKDIPEGGSKGTILVSSRYLNKFDEVRCQHIFLQYVDAMLDLIIPGEKGVVDSLKSEEIIFLGPDENTAGTFPAAGALYSKGRGYKAWKSFTTGKDPELGGIPHDVYGMTTHSVRAYVTSIYEKLGLKESEMRKFQTGGPDGDLGSNEVLHSKEKMIGMVDISASLHDPTGINRKELARLARHRLPLREFDRSKLSPEGFLVLTEDRNVRLPDGTLIGDGARLRDEFHFLKYSDADVFVPCGGRPRSVTLENVGRFLKVPDADGESMMSDKYTNLSPEQLKFKIIVEGANLFISQDARLALEKCGVTLIKDASANKGGVTSSSLEVFAGLCLSDEEHAKYMSAKSAADAPEFYKKYVQEILDRIEENAKLEFNAIWREWEKDPHQSKTLIADALSKKNVQIRSNILSSDIFQNDDLVRYVIAQYAPKTLKEVVPVDVMLKRVPKNYQHAICAMWLASRYVYQTGVDSNEFDFFSYMTEVYTNVAKWAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPC1</accession>
    <name>A0A088RPC1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_204580</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698659.1">
        <property type="nucleotide sequence ID" value="XM_010700357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPC1"/>
    <dbReference type="GeneID" id="22574670"/>
    <dbReference type="KEGG" id="lpan:LPMP_204580"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200052500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_204580"/>
    <dbReference type="eggNOG" id="KOG2563">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="422206at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17334">
        <property type="entry name" value="MFS_SLC49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049680">
        <property type="entry name" value="FLVCR1-2_SLC49-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 49 MEMBER A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="495"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="529"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="557"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="228"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN97952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="728" mass="78209" checksum="FF56E14FBF6AF68E" modified="2014-11-26" version="1">MPATLMAEKGDPWRWVVLTLFCLYSASNAVQWITYSSIATPTRAFFRLTTNELNMLSSVYMIVFVVGAYFTCTTFERWGVRLGVLIGCGLNALGSILKVAPGLQRPCYATLIVPQILNSIAQLFVLSTPPLIAAHYFASNQRTFATAIAATANSLGNAIALFAPPLIVKSSTGTMKEFMLLFCLELGFCVLITVGVFFFLRTPSFKSPSKALLRELAATQGSVMTGRASLSGAKQVHQRRGEREEVVADDGLQSEMDSNGPNGNRSSEEGESDDNDADAGQGHAVNHGHRRMAPSEPIALHTSECAGAHDNHTNAPRLAVGFTDAESPGKPDGGACSTQAGVLDPSAAVYTEWDRGSMSKHKRMTVWRRLRHSEHVITFLEVGHTIYLLLRRRDFVFLLSAFSVSMGSVWTFASVLAQILEPFGVAAELAGSIGAANIVLGTVVSYLIGLWVDRTRHYKSPLCVCMMGSVLCCIGLIVIMLKAPSHSRTMDGLCSFIYIFAGVFQNTAIPICFEYSMEISYPLPESVPGALLMAGANLCSLIMLSIASAMLGDGVASTSACVNVLILITCVCFVGAVLSIFPRERLYRHDAEVEARQQLVAKPAGTYAANTATTQPFHWCSVTTYSQQPLSGVGSATQGVSVPLSGGAGNDAKAEEEILPFAERRSSTMEAPSAGAAVRKSVFAEDELLDDAPADALQLNDRIARSEMNDATSALAPQQGRGMHLRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPL2</accession>
    <name>A0A088RPL2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_202640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698467.1">
        <property type="nucleotide sequence ID" value="XM_010700165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPL2"/>
    <dbReference type="GeneID" id="22574474"/>
    <dbReference type="KEGG" id="lpan:LPMP_202640"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200032200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_202640"/>
    <dbReference type="eggNOG" id="ENOG502SB4H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270783at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="294" mass="33430" checksum="220A215AF3FC66FA" modified="2014-11-26" version="1">MASLTTQRRGVAIASYRCEDRVFPVLPTAHPLSVRRREVQRFLKGDDIQGRRAWNPSTKDELHPFPQPALTHTTTCYNGVDVVSTHFPETVKGTAFLRMQETVLPAVWTHNRDRACASAKRHTYRCEALMHQEAPLSYLATVIRDDNSPKRKRLREGWCASRTLEGFHRNHHIAPAPEDMSHAETHRELNKTLTARLSGGYVSPYDRVKLLNSSRKMQRELKENATAESLVAFYASQPGPAVFKMSNADEWWDMDPVAVTRDMTVRAEASKANPYSTIFRSSVSVTTTRKPQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPU4</accession>
    <name>A0A088RPU4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Aconitate hydratase</fullName>
            <shortName evidence="9">Aconitase</shortName>
            <ecNumber evidence="3 9">4.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_180630</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.3" evidence="3 9"/>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697897.1">
        <property type="nucleotide sequence ID" value="XM_010699595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPU4"/>
    <dbReference type="GeneID" id="22573953"/>
    <dbReference type="KEGG" id="lpan:LPMP_180630"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000021600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_180630"/>
    <dbReference type="eggNOG" id="KOG0452">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2224430at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072350">
        <property type="term" value="P:tricarboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01586">
        <property type="entry name" value="AcnA_IRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01580">
        <property type="entry name" value="AcnA_IRP_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000005">
        <property type="entry name" value="cytoplasmic aconitate hydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044137">
        <property type="entry name" value="AcnA_IRP_Swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006249">
        <property type="entry name" value="Aconitase/IRP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01341">
        <property type="entry name" value="aconitase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006757">
        <property type="entry name" value="PRK09277.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009520">
        <property type="entry name" value="PRK12881.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11670">
        <property type="entry name" value="ACONITASE/IRON-RESPONSIVE ELEMENT FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="10">
        <location>
            <begin position="84"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="11">
        <location>
            <begin position="698"/>
            <end position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN97244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="896" mass="97428" checksum="5B5C4FD6D133F5B9" modified="2014-11-26" version="1">MFRTGIQLAKKCPRPNPFNAKFLTSLQADGGSAKYYKINEISAKYCHLPFSIRVLLESAVRNCDEFDVTSSAIESICDWKVNCTKGIEIPFKPARVVLQDFTGVPCVVDLAAMRDAMKRLGGDPRCINPQIPVDLVVDHSVQVDCSDTPDAVEQNQKMEMHRNRERFEFLKWGSKAFEKLLIVPPGSGIVHQVNLEYLAHVVFNTDGLLYPDSVVGTDSHTTMVNALGVMGWGVGGIEAEAGMLGQSLSMVLPQVVGYKFTGKLMEGCTATDLVLTVVKNLRKLGVVGKFVEFYGPGVDALSVADRATLANMAPEYGATTGYFPIDEETIKYLRSTNRTAMHVARIENYVKAVGLFRTGNEKIEYTQDLELDLSTVVPCVAGPKRPHDNVPLKDLSKDFKACMSAKTGFKGFGIPEGEHAKRVKYTVNGQEATMEHGSVVIAAITSCTNTSNPTVLVAAGLLAQKALKKGMKVAPGIKTSLSPGSHVVTKYLENSGLQKSLDALGFSTTGYGCMTCIGNSGEIAPEVSKCITENNFVAAAVLSGNRNFEARIHPLTAANYLASPPLVIAFALAGRTNIDFDKEPIANGVYLRDIWPSNEEIAEVVNKFVTPGLFKEVYANITTMNAKWNMLQVEEGEFYQWDPKSTYIHNPPYFDGMTLDPPGAKSIENAACLAIFGDSITTDHISPAGNIAKDSPAAKFLMKQGVERKDFNTYGSRRGNDEVMVRGTFANTRLGNRLVGDGQTGPYTVYHPSGEKMFIFDAAMKYKAAGVPTVILAGKEYGSGSSRDWAAKGPFLQGVKAVIAESFERIHRSNLVGMGVIPLQFKGGESVTSLGLTGKESFSVKLPGEMRPLQDIVVKCSNGKSFTAVLRIDTEMEVKYIENGGILNYVLRSKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQG5</accession>
    <name>A0A088RQG5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Anaphase-promoting complex subunit 4-like WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_191430</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698137.1">
        <property type="nucleotide sequence ID" value="XM_010699835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQG5"/>
    <dbReference type="GeneID" id="22574197"/>
    <dbReference type="KEGG" id="lpan:LPMP_191430"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190021600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_191430"/>
    <dbReference type="eggNOG" id="ENOG502QRKB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10248252at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001089">
        <property type="entry name" value="WD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="5">
        <location>
            <begin position="180"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN97484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="391" mass="42310" checksum="D0318F435A6DEA2D" modified="2014-11-26" version="1">MSTSGSSSSGGDVRRFSRQQIIQHVKKSLLYTAFDVKWVPQTASFAVVGQYPNNHGALSLYQLHHGDVQPTAEVRLPHPLKCCTFGHNVSFSSSGSAAGAAASQMACGDFAGSLQILDLSRLSSTPASASNALSDVTAASVFHIPHAHESIINAIDGARYSGPPEVATGSRDGSVKVWDTRQSNKPVVSLNPADPARARDCWTVRLGNSFDPDERVVAAGYDNGDIKIFDLRTQKMLHEIHVSNGVCDLEFDRPDIPMNKLIVSSLEGRVRCYDMRTLHPKLGYAYVEERVSEGTVWCSRALPQNREILLSGGGGELTLCLYKYPPERTLKDGDGLQRGVAGAVEELNKAKVGDQPINAMDWNRSKEGLAVCASFDQSIRVILVTKLGLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RR56</accession>
    <name>A0A088RR56_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nicotinamide N-methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_230110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699170.1">
        <property type="nucleotide sequence ID" value="XM_010700868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RR56"/>
    <dbReference type="SMR" id="A0A088RR56"/>
    <dbReference type="GeneID" id="22575215"/>
    <dbReference type="KEGG" id="lpan:LPMP_230110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230005900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_230110"/>
    <dbReference type="eggNOG" id="KOG2497">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="413520at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF130">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EEF2KMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="261" mass="28930" checksum="642CAF4371E360BB" modified="2014-11-26" version="1">MNTKGGQRNVLVGACYDSKYANVETLRKLVLLDCRYAWVDLPFSTCAARYQMLARQRGAAASGPTTRENAELVALLNTDSIPQYVWPAANPMCEWVTSHSNMFEGKSVLELGCGAGILGFTVAQHARQVVLTDCSPVSLALVLESVARNDYRNCDVAVLQWGREDQLAKIKLECSVDSFDIVIGSDIFYFSNSLKAGLETARSALLPRHDSDAVFLCGSVTRSDRMEFDLEQIPLREGFVLAELLVLDPFRLYIWKMSASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RR70</accession>
    <name>A0A088RR70_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquitin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_201800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698381.1">
        <property type="nucleotide sequence ID" value="XM_010700079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RR70"/>
    <dbReference type="SMR" id="A0A088RR70"/>
    <dbReference type="GeneID" id="22574389"/>
    <dbReference type="KEGG" id="lpan:LPMP_201800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200023400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201800"/>
    <dbReference type="eggNOG" id="ENOG502SREY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="419317at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000306">
        <property type="entry name" value="Putative ubiquitin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="80" mass="8637" checksum="D02205EEC631B0C6" modified="2014-11-26" version="1">MTFSFSVISTTGQRISISVLGPDNTVGDIKAKLEETEGIPQKMIMLVHSGRKLEDNATLEECNIHAGVTINMVLALRAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRI5</accession>
    <name>A0A088RRI5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_230650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699222.1">
        <property type="nucleotide sequence ID" value="XM_010700920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRI5"/>
    <dbReference type="GeneID" id="22575269"/>
    <dbReference type="KEGG" id="lpan:LPMP_230650"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230012300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_230650"/>
    <dbReference type="eggNOG" id="ENOG502S4Z5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272043at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="608" mass="63670" checksum="DD627B40C9DB8923" modified="2014-11-26" version="1">MNVLHSFVKVTFGPVTAAEEDLANSPFAPTEKMKVVSRQPLTFCLTVTYDNVARDVSKEQAAKTFLSMVGVHSLETAWSHLFGAVQVVPFLLYKSDSSAGSEGKKPSSVLQASSPSMLPFTSEVWINCTGSAFVCGTPQFWSSHRYTWSLSGATPRKDVSTPLHESTMTELSLLATLPPSMAGHSLPTVMATTSLSCTNNSNSGCTGRRASPGDGDAHWDASAGVHCEVIGNVLTVAADEGSPRRLPAEASAAGEDVPVDFTGAALPDLLESKYAIELALPDFEAASLRGVDTALVMVVLLPLCAAGGGGAVEAGDPPLILRSVLARSVGSMQAASALVFGSGVMPVQLTEPLVCVSSTSPLSNDRLVLNLSVTNVTASVARLHSTSFDLHSSCVLCDAAITGGALAGAKQGEPLLTASSLWGEMRPGANLSSMRIIDLLTKLVTITPVVVGEERPPVVLYPGETYTFEFVIEVLPQLCYLLNSQSLEYLYERHYAVPHGVVGGRGSDSSPSGKRGEGGSRSGGGSSAAATFSRGSIVTDCYGQTVPAAEIRGILSYSYLSHLFVYYDLGMGDTASNGGSARKPSRVSGLAHSTELCLRYPARWSFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRT1</accession>
    <name>A0A088RRT1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_204560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698656.1">
        <property type="nucleotide sequence ID" value="XM_010700354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRT1"/>
    <dbReference type="GeneID" id="22574667"/>
    <dbReference type="KEGG" id="lpan:LPMP_204560"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200052300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_204560"/>
    <dbReference type="eggNOG" id="ENOG502SKHA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273868at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="341" mass="36727" checksum="8D9BAA2D86E59F3A" modified="2014-11-26" version="1">MFEEALRQAPREELVEHIQLQRELIQRLHRRVLELESSLESMYTCSSADCGADSAADCRASPSEQQRSALSTNARPSPSHPAYPQCVGGASGGGTPQTARTHPSVTHRETSLAFNNLWRADEDGAVTAPEPRRQPPHPHTEEKAPTTFASLSFSSQRQANAHVALATYNNGTSATTASAPALPALSSAAASSTELTSSSVDHPTLLEGIKEINYVLAAHRAGHPALPLPVVEELEDIRTRLLLGFKQTYVMGDRDDGTAQAAAAACQAYCALPQGEEAVPYEVPLDLLFERRADAFSDASRVCPRWISPDSSRVVYGTSPHCHPVALRGGNRNGEEEEEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RS55</accession>
    <name>A0A088RS55_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_241660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699505.1">
        <property type="nucleotide sequence ID" value="XM_010701203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RS55"/>
    <dbReference type="GeneID" id="22575575"/>
    <dbReference type="KEGG" id="lpan:LPMP_241660"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240023900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_241660"/>
    <dbReference type="eggNOG" id="ENOG502QUIU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="438641at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.140.2220:FF:000023">
        <property type="entry name" value="SET_domain_containing_protein_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF297">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="99"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="379" mass="42189" checksum="DAE6155447583ADC" modified="2014-11-26" version="1">MSSNAIRAAWNGAVELKRHCSHVINTLGPQTPPEAFLYRGNAYYALGQPYFALADYNTAGSVLRLSGEHQRRCRKVLESFPETQTGVYPSTDSHLHIFVKPTLAKSCAIETINEHVGRGVRATENMPRHSVVVQPTSPWLLYPTEEGLCSHCGASLPERSFACANDSCHEEYCSRDCRQEAMAHYHAAVCCNKDYQSIELDVFAQMTEAEKAGAVAERNAAAAQLLMLRVLSTSIQKHVVPSAMGQVRILSGRLTFSPQVLSRSMLHLYERLAHALRISTIVSYEEVVGILARITANCFHRDGSVELNLPRSMLNHSCAANVAEDGQTGAMITTRDVARGEELVINYYPHLKDLAYEERTTELERRGFPCMCAKCQRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RS81</accession>
    <name>A0A088RS81_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_241020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699442.1">
        <property type="nucleotide sequence ID" value="XM_010701140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RS81"/>
    <dbReference type="GeneID" id="22575511"/>
    <dbReference type="KEGG" id="lpan:LPMP_241020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240016200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_241020"/>
    <dbReference type="eggNOG" id="ENOG502SH8T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266978at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018527">
        <property type="entry name" value="Rubredoxin_Fe_BS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00202">
        <property type="entry name" value="RUBREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="471"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="655"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="689"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="713"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="957" mass="104227" checksum="F2B4E88DB652A450" modified="2014-11-26" version="1">MNAHTQAHWFERSGTIQTSQREKRTAVSSRLPSLLLLPHPSTRVMAVLHSPAERACDIAIHLSDTAFTSRIDYTDAYVLPTTSTTETASTDVTPLPTAALVSPWLLVGPSASDAHPSSSLPAVATAAGTTISPAVETVPLAWRCPSCGTLEVEQLYWRRPRRSKSPTTGGAPAAADVRAALARSMRLKAPSPALQARLEQHRRRSERREEMRWRSLYISTRCRRCFLCPRCGGHGSLPSSETATVSDVSTSKSAAASLSPSLNAATLLSSMQSVSSLDIRLTSDMQYYTVCACCQWHSYRAFPTMEQLLAYLNAVMGDEKAEALREHRAAQRSVNTALRAGLTGLLGAKPDLEDDVSLQQQQPTISQAAWDAFRLLRSLHIHNQNVSPPSHSPPPQQQSVEGEQQLSNKIATDTIIHLHPALALEQLQNQERQRREAARAVSLLQGMSQVAPQTMRVVDLAREAAAQLQAAREEEEHDMTPLSKLPPGYRLTTSASNTARSVKEDVEVDLIARTQQCYLGLPVETVDTRDQTMRAWMQRYQPAAVVAQERKAAAAAMTSTSALMHTPTSAYLHSVLLREQDRPLGLPAYYIPRVRKELLTALVWRLPQASAAGQSSATKQVCPCTRLVLLDRSALLDDEIRQVCQHWVDQRTAQVEQHKRKHRSDLEQQNSAGSTPAVGMQRNHGDGGFDSDGEDEEDEDSDGAIEHPKDGASQDSMHATTSRHPQPQQGLRQKALSVLPVPLFLDGTDFAAVSCLPFLEYVRNGGSSARPCERQLRLVNLRMMHDIYLTKLEVARTVLAPTCFIDAQHARPPSSPSSDSTPCVTVHLSSPSVPAVKLPLALAPQCSPVERAAAVAAVLKGSDGACATEASPLPPHVPPSLLTMGNTTPPIRLQELHLTLCETSAAQACMPSPSPMLAPLHCVELLVEVATALSGVDHARPQYHSVRYGLTVTFNSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RT09</accession>
    <name>A0A088RT09_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_261440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699964.1">
        <property type="nucleotide sequence ID" value="XM_010701662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RT09"/>
    <dbReference type="GeneID" id="22576047"/>
    <dbReference type="KEGG" id="lpan:LPMP_261440"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260019400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_261440"/>
    <dbReference type="eggNOG" id="ENOG502SJ3P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265599at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="365"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="510" mass="55790" checksum="970E4FEF80B357A8" modified="2014-11-26" version="1">MSFLSGIECAVDLTPSHAYRCALQYIKWALSSCTNGVNKKCRSGARARRQLGHSVIADTKFVQVARWCILPLPSAAHWLPWCFFFAKSTMARRRKLNHTLSFSFTLPPPPSSSPSRIHRAAVLGSSPSVPRLLFSALRLLSFSGAELLVSGVRLSTKLTRSRSAMTSTTDNTSCGRHQRRLGDSVVVSRTFFYMVIGVLLCLPVSSSAAGYNASAHVNSDFAVNALTSELKVIMLVESSPRNFSSDAFLGNLYNLYSSADTAIANISCVSIVNWCASNSNVLNTTISCPNGTKYNNNSNYTYVYVQVQLSGWDRSTTVLPSSVDLSSAGVISNSIVTYFPGLYNPDLNTSGTGGGLILEFTSDLVLTYAVFGVLMAIAVFAFIGVAVCVCLCDNRQLNRNKSVMDRAIRAVHLNYVAALYGRRRHQQQQPAPAGFNEHYNMYADITYNGSADALRVSQHSLNSPQTNGGQATARGNDWVYSPREADNTHEMEEVGDPQSRDWDSAKHKRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTA5</accession>
    <name>A0A088RTA5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nuclear lim interactor-interacting factor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_260160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Probable phosphatase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CTDSPL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699837.1">
        <property type="nucleotide sequence ID" value="XM_010701535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTA5"/>
    <dbReference type="GeneID" id="22575919"/>
    <dbReference type="KEGG" id="lpan:LPMP_260160"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260006400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_260160"/>
    <dbReference type="eggNOG" id="KOG1605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000015">
        <property type="entry name" value="CTD small phosphatase-like protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="5">
        <location>
            <begin position="108"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN99130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="290" mass="32875" checksum="18B15B0A3007E5CE" modified="2014-11-26" version="1">MSSAHKPTTQEAINFFKQYRAKFQSGCSEGNSPSQNSVNASRAQNIVTQVQQVGVVADPTTRSIVPMDRRSGTTTTRLDLLRKSPTNCSPCLLQDVAIKPLLPPLPFASVPKVTLVLDVDETLVHSTFQPSSDVVYDKVLHVPSDGRMYTVSVKYRPYLEDFLRFISRRFEVVVFTASMRAYCDKLMDEIDPQGILGNLRLFREHCTLCERSYVKDLHRLGRDLRRVVILDNSPAAYSFQQRNAIPIKTWINDPKDCELFLLFPFLDSLSMCGSVYSELDLYNARGCDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTC2</accession>
    <name>A0A088RTC2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_270220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700109.1">
        <property type="nucleotide sequence ID" value="XM_010701807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTC2"/>
    <dbReference type="GeneID" id="22576198"/>
    <dbReference type="KEGG" id="lpan:LPMP_270220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270007700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_270220"/>
    <dbReference type="eggNOG" id="ENOG502RZGC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275765at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1410.10:FF:000042">
        <property type="entry name" value="Hypothetical_protein_-_conserved"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="34317" checksum="299589741CB89213" modified="2014-11-26" version="1">MQSSADSFWAACGGCGVTSKRLSIHKTAAAASPIGLVTGEAVKNGSLLISVPYNSVFNGQTLRGDVLPRALPPLRKMILFLTRRGRMGAITAHSLWLACFVACYRQQCAVSNVAERWLLQQLLSDTVYPLLPNLFSERNKFTCPSLRGSSAAELQVMEMRVLDELDLTYSMLCHYMKRRGVSSKLRPSRDMLLQAHRTVMQRALLLPCNGVPSAPAELSELIETSPDLALFPSLVPAIDLIRAAPLNSRTEAEEGKAAESSGNCAIFTCVQSDFVSPSSRRRLIVETAPLATRRVVICATKSLKEGAELLMEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTS5</accession>
    <name>A0A088RTS5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_261980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700017.1">
        <property type="nucleotide sequence ID" value="XM_010701715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTS5"/>
    <dbReference type="GeneID" id="22576101"/>
    <dbReference type="KEGG" id="lpan:LPMP_261980"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260024500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_261980"/>
    <dbReference type="eggNOG" id="ENOG502S7RF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269639at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="94" mass="10713" checksum="F0A22C84115D466A" modified="2014-11-26" version="1">MGRSNNQRRRTCKARGQSFIPKVVKSKVRNENRRMKIMAAKKDPRLHKKLSYDKVHTKSGKITKRKFQSGGYNHSGKFGKAAGVKRNAAKGRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RU46</accession>
    <name>A0A088RU46_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_271690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700255.1">
        <property type="nucleotide sequence ID" value="XM_010701953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RU46"/>
    <dbReference type="GeneID" id="22576347"/>
    <dbReference type="KEGG" id="lpan:LPMP_271690"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270024400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_271690"/>
    <dbReference type="eggNOG" id="ENOG502RXDZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271226at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001201">
        <property type="entry name" value="mRNA_export_factor_MEX67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057127">
        <property type="entry name" value="NTF2_MEX67"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030217">
        <property type="entry name" value="NXF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662:SF22">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23056">
        <property type="entry name" value="NTF2_MEX67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="2">
        <location>
            <begin position="15"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="616" mass="67190" checksum="B79E250FB3DD3195" modified="2014-11-26" version="1">MSRPYKKSKGAGGITKYNTPCKFFLRGSCSNQRCPYLHVRNQTVIRSTSHKEVAAQEGNGTVKVMSTMLKLFFEKQTQLIYNAETGMLNLSQLASYDDLSSVASSINFNTRTFCVALCTCIRELVSPPPAVLQLDRNELKGFHHLGKALEEAGLHASLRALSLAHNNITSTTIAQELKHFSNLTELSLVGNPVRESVDYKLNFKKCVPWLQGLDGESMAAPPLELPWPRFFDPKHTLTDEGSAAQGFFSSVRGYDSIQKALLHFIQSAVLNPLEMEPAPGLLTGVDAVSDVYALNATFTFSLVSTEAAVSTPSRTAGGSAASTQRDVVREIVGFRMRQTESNHNVLLGLKSTTVAVGRTSVCAKLEHVLYPKNFVVGHYIHESPDVAVLDNKGFGPNAIVGMKQPLSVITLHGVMLWRYRTTGSDADVQHASLLRDALVIKRNFTRVITVSSTEPGRWHIVNDMVTLFPFRGGSGNEGELGASNPASGGAGVSTAPLTPESILFRDVHPYDVVFSPATDPKRAALIARRYRVPAPIVTTLCSVVHSDRELAVILVDLTDIPLEVYEQCAPVVEMDPLASIFLCRIGNRFSIEPAEGVVLLQKCGLDWPAIEQAVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUK8</accession>
    <name>A0A088RUK8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_250970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699666.1">
        <property type="nucleotide sequence ID" value="XM_010701364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUK8"/>
    <dbReference type="GeneID" id="22575745"/>
    <dbReference type="KEGG" id="lpan:LPMP_250970"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250015700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_250970"/>
    <dbReference type="eggNOG" id="ENOG502SH1K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="263816at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036339">
        <property type="entry name" value="PUB-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143503">
        <property type="entry name" value="PUG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="442" mass="49463" checksum="8899B8649624508F" modified="2014-11-26" version="1">MNFATAEASATAEASVQSVPLLITCLHASAVSTPPTEVRRAFDIIEKLLSNRVQHPAEQCYTSFSATSTAWVNRVLPLVYALRLAAWMGCTLTAEGTRYVFIDNLSKAHAPVESNAEDRRRRRDQKQQQQQLVDRLDELRCVASVWNMSVAEISVGASRRYQDAYGELLKLFQSAQDSIDREEVWTRHINCLQLYCLLARVHGVEWQQVTTLSQAASDVLSGECAASWTARAQRELDRSLCASSSVPLCNAQGSSMTRTLPVLDARRTCRRGCETLATCLADDSLQWLLSRVSLCELRRMCESAVAESASGAAGGRESRSCTTVPLIPGFSVKVAERLRQQAQLDQHQRYIRTTGPAYRRLSQEERRRGESLILSIAALLQQIVEVSETQGMVRHDRHEARRLMDSFRQDGNLVKLYALEEQYMAALEEAKLLYGKPLVYTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUM5</accession>
    <name>A0A088RUM5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_251110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699681.1">
        <property type="nucleotide sequence ID" value="XM_010701379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUM5"/>
    <dbReference type="GeneID" id="22575759"/>
    <dbReference type="KEGG" id="lpan:LPMP_251110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250017300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_251110"/>
    <dbReference type="eggNOG" id="ENOG502QRNP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4726at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="92"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="242"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="244"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="307"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="382"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN98974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="441" mass="47864" checksum="558ED2383D6AD02C" modified="2014-11-26" version="1">MPAKQKKGRGKTVNLFEFNEDYIPEEALDWAEDDWMTAEQVGEAKLSEKFARQRQEYSRMTNNTLDQQESFRTAAVSEQKRSFTIDDLQPPFVAHFGNLRNGTTEEDFLSLFNRDAIATHRLINQDGKSFAFVEFVSAQALTVALSLDQTFQRGRRMYVDLATQKQVERLLNRNTNERPGMSRDAAGQQQPAGLAVMGLSRDVFGGQQPEDQPGMPMMGGRSNFGSRVDLHSLSDLSRDMLGSAVQQASPTSGSPICSAGSPLNFGNWRNDTPEQQPEFSILHDNGRSEDGIDLRAGNLRRSSGPASPTPPAALPEPRPNPFGGEMGNWRDAPRAEVPKMEEAPAVAAEGDATTLSKRKSEENNAGGANNSGAASGTNSNGRGRGAGGLGRGGAGPSDRSYFAGERSGFGGERSGFGNERYAPSKPPGPVNMDKWADLRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVP7</accession>
    <name>A0A088RVP7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L35, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_262300</name>
        <name evidence="5" type="ORF">LPMP_262310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700050.1">
        <property type="nucleotide sequence ID" value="XM_010701748.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700051.1">
        <property type="nucleotide sequence ID" value="XM_010701749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVP7"/>
    <dbReference type="GeneID" id="22576133"/>
    <dbReference type="GeneID" id="22576134"/>
    <dbReference type="KEGG" id="lpan:LPMP_262300"/>
    <dbReference type="KEGG" id="lpan:LPMP_262310"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260027900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_262300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_262310"/>
    <dbReference type="eggNOG" id="KOG3436">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="262879at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00427">
        <property type="entry name" value="Ribosomal_L29_HIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.310:FF:000002">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_uL29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_uL29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045059">
        <property type="entry name" value="Ribosomal_uL29_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_uL29_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="Ribosomal protein L29 (L29p)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN99343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN99344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="127" mass="15154" checksum="1082507D452D8A98" modified="2014-11-26" version="1">MSHHMKIKDLREKGKDDLLKKLTEYKKELSQLRVVQQTGGAEARLGRIRSIRKSIARILTVLNQNERQNLKKFYSDGKMRSKMPKVLRAKLTHRRRLALKDNEKNRKTLHQLRQAHKYPKRVYAVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVT5</accession>
    <name>A0A088RVT5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CAAX prenyl protease</fullName>
            <ecNumber evidence="9">3.4.24.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_270040</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Proteolytically removes the C-terminal three residues of farnesylated proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic side chains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.24.84"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8 9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M48A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.84" evidence="9"/>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700091.1">
        <property type="nucleotide sequence ID" value="XM_010701789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVT5"/>
    <dbReference type="MEROPS" id="M48.020"/>
    <dbReference type="GeneID" id="22576180"/>
    <dbReference type="KEGG" id="lpan:LPMP_270040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270005700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_270040"/>
    <dbReference type="eggNOG" id="KOG2719">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="360839at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07343">
        <property type="entry name" value="M48A_Zmpste24p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.10:FF:000016">
        <property type="entry name" value="CAAX prenyl protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027057">
        <property type="entry name" value="CAXX_Prtase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032456">
        <property type="entry name" value="Peptidase_M48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10120">
        <property type="entry name" value="CAAX PRENYL PROTEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16491">
        <property type="entry name" value="Peptidase_M48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 9 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 9 12" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 8 9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 1 N-terminal" evidence="11">
        <location>
            <begin position="34"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="10">
        <location>
            <begin position="222"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="369"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN99384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="427" mass="49245" checksum="77001B45A1157213" modified="2014-11-26" version="1">MLFSTNLFLGTTLISLNAISVWDAYLVLRQRRANEAKGMPLYFKEYITDEEFAKSKAYASERSTFSFIQHVKGLVMRNVSILLRLPARLYYLAMQPTGFSAGSFSHNYAAAVVEDLIFTVLDIPFSYYENFYIEKRHGFNKMTKTEFVKDILKSLFLRVTLLYPMQIALIQFVVRRFGERFPLYLFSGMSVILVIFLLAMPTLIQPLFNKFTPLDTEMLLYKKIAQLSTELGFPLKKVFVVDGSRRSHHSNAYFYGFGNNKRIVLYDTILEQLKDDDESIIGVLCHELGHWKHSHMYMNIALILGQLMLVSYGARLVLFDKRVYEAFGFGEIDPVIGLNIFLEPFYSTLSTLFGYGFCSISRRNEFQADRFAVKHNHGESLKRALLVMAKENRTGLTSDPLYSALHYTHPPLLERLQAVDAELKKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWK7</accession>
    <name>A0A088RWK7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_301890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701214.1">
        <property type="nucleotide sequence ID" value="XM_010702912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWK7"/>
    <dbReference type="GeneID" id="22577242"/>
    <dbReference type="KEGG" id="lpan:LPMP_301890"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300023200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_301890"/>
    <dbReference type="eggNOG" id="ENOG502SI9V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="262000at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="673"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="728"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="827"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1011"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1069"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1134"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="874"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="901"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="923"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="941"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1011"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1072"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1085"/>
            <end position="1098"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1171" mass="125995" checksum="635034A9C9FBCF2D" modified="2014-11-26" version="1">MPSAQSLSERQRHARFSLLPSSTAFLSFDVLEWIPSKDSASGELLALRPARGVASEHRYNSSASVASRERRVHPRDCSAFESSVGSWACFRTLSCYGDILVLEDAQSVDVSAAHRHEYTWQQGPSCLPLEGEVNASFGASTDHRPMPASVSHNATHIGTDIVPREALLTTRRLGRPAHRQHHPTHEIPMRDVHSVRRHSFQTPISLLFDARGHLISERESSDTAARSDRAKWLVPRRRHHRNGSSPKVSSLQWRYELWGPVGVTFTLRGGRRIFLAFASAQHAEQIEKLLIRFATGAKLSREEQRCHFNQRNNTDASASVLQMPARSADDDMPYAASAGEVFVAPLSPGVLQRTSLQSFTSEREASLRKAPATPASPRVDTASPSTWAFAAHSLVSSTPAGLPPQTVVFARGNSLLGLSGTATASHEVGCAPAWETRCGSSKPPGRGYLYCRPWGEASRYRRYYLKMSTTAGMSHIAHLSRHRLRLWQRLQQAFGNDKHSVWLDLRRTSVSPSTAHENLLLLAPQVESFTQHKNVELLGSGVTLVGPASKSSAARAARRREPELCTGRPVVFEALAKSPEERTLWLAWFCSHGATVPTPVSDVQMGDSADVLPTPEASAVFRQLGGAELFTTSPAIGAEQNAFLSNTADRWVSSWETSTLSVETFPSAKPLGIGTPRLPLKEPSEGQRGGLRAPAEAIAAPRLSPPFPEDLSKASSSLRKSLLASGKHVSRRAHVQPPPALAFSTGDRKGSEAELSIVVEDDDLDKVALYPETAVPHSAGRLMRSDSATVDHVVAPLCRTPAPPLLAEAARWPRSSSERAAEAPNIIAVAEEKPKTDHTVTSNGPSAAPMYLEDTASSELSSPERSDESPPQLLATTEKSPRPSSSISTPQDGSNSPKQYNKSETHRGHSETPLEPTEAAQRATCTASSTVALVTSQPSRPATTTDGGATPAPLKASLTVAASTSFPAEQYQDRSGCLNSGSTPPRTVKPEAAFFTATSVEVSFTTLSQQMRPTSNRISSTGAQPSAAPPAALRRTMEKPTGTSSSGRMDHQLCDESVISGLRHGARVIQDTSTSSSPAPSSRESLVKGDGDTHDARVSEMSSLSPLAPERGLLPSSSSVVDLRLLQFLEARVSETSDDQAGSCRGSCRRGGGTPIRLASTPFDLHVVPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RX70</accession>
    <name>A0A088RX70_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_303190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701341.1">
        <property type="nucleotide sequence ID" value="XM_010703039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RX70"/>
    <dbReference type="GeneID" id="22577372"/>
    <dbReference type="KEGG" id="lpan:LPMP_303190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300036800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_303190"/>
    <dbReference type="eggNOG" id="ENOG502S09Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268381at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="141" mass="17628" checksum="FF4233CDF760DE47" modified="2014-11-26" version="1">MLRRTISKLYRYQEFEMHNEAKYPFNYPREAPNTSVFHQYHLNFWMFWGYGRQELWIDRDNRRYETTWEMFRRLLMWFFPCYFIFPFGLPKFFAANAFGEYGEKPYLDAMMHSPMDNYYIEWGGSTLDAEWLRHIHSKESF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXK2</accession>
    <name>A0A088RXK2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NF-X1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_290590</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NFX1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700667.1">
        <property type="nucleotide sequence ID" value="XM_010702365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXK2"/>
    <dbReference type="GeneID" id="22576823"/>
    <dbReference type="KEGG" id="lpan:LPMP_290590"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290010000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_290590"/>
    <dbReference type="eggNOG" id="KOG1952">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6512771at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06008">
        <property type="entry name" value="NF-X1-zinc-finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034078">
        <property type="entry name" value="NFX1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000967">
        <property type="entry name" value="Znf_NFX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12360">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR, X-BOX BINDING 1 NFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12360:SF12">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR NF-X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01422">
        <property type="entry name" value="zf-NF-X1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00438">
        <property type="entry name" value="ZnF_NFX"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="NF-X1-type" evidence="10">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="10">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="10">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="10">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="10">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="10">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="10">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="10">
        <location>
            <begin position="542"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIO00010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="578" mass="63445" checksum="26DAC9594BA50E81" modified="2014-11-26" version="1">MSASPQLTQELTEDLLGGRYECIVCSESVGHRQELWACQCCYGVFHLPCIRFWADSQTKERERQLQSTSGVATQGELVRFRCPLCQSFNKKDSLAVYRCYCGKTTKPPVDAMLVPGSCGQPCERRQADPCCPHRCTLLCHPGPCPACTRAREQACWCGKYSKTVGCSSSIHGYECGETCDKVLDCGHHRCKAPCHEGPCPVCTVMVTEKCHCGATERTRRCGAAPPTLAGAAAATTQDNGAAEEGRAGAVVSDFRCVRHCEKKRDCGNHVCGMLCHAGVCEKCYRTPQRQKFCPCGKTRVQGQRTSCIDPVPSCGLTCELPLPCGHLCWLTCHDETPCAPCKETVTTPCACGNRHISSPCFCQYLPESEWEAARVQCGLPAGSLPSSMPPKCSQVCRRMLSCHKHRCTNTCCTDAEHTCLQICIRKLTCGEHQCGRLCHQGTCPPCTHISYERLYCRCRKTWVEPPVPCGTRQPQCNHPCSIPRQCGHPPNHPCHIEPECPKCVVLEEKACASHQKPMPFHLPCYKAEVSCGRKCGRNLPCCGKFCELVCHSGPCEHNCSKRFPTLGDVLKRGKGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXR6</accession>
    <name>A0A088RXR6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Microtubule-associated protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_311180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701506.1">
        <property type="nucleotide sequence ID" value="XM_010703204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXR6"/>
    <dbReference type="GeneID" id="22577544"/>
    <dbReference type="KEGG" id="lpan:LPMP_311180"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310019000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_311180"/>
    <dbReference type="eggNOG" id="KOG3595">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="447173at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703:SF36">
        <property type="entry name" value="DYNEIN HEAVY CHAIN, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain coiled coil stalk" evidence="3">
        <location>
            <begin position="107"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="331"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="518"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="100"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="431"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO00706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="620" mass="68577" checksum="8477178A57FB4E9E" modified="2014-11-26" version="1">MPTNKNIAPPRKPNSPMKVLPTSTDTDYSVLTKISSVAHVCVSVNDLVAFEYVCEETKGWKWGLGTVAAILGPRLVQLMLWIGNGGETPPEESPVSDADRAAAVKRLEKLQRMRQEAEEEMEDLNKSLTVQYAHYNEVRAAYEANAVRAEEAAAEAREEIKNMEETDWREIRSYVKPPDIVKLVTEAMMLTLGERFLEWNYVLKVIRQRTFLKRLEVFDSQSIAPATRRRVRKEYLSNPRFTHRDSMEGSRALGIVQRWVVAQLATSEAKVDIIDYDRMWTREKKGIEKMESTLRQRRGEVEGYREEEVRLKRQLGDSPVCLDYSKCANGAAAPRPKGISTKNGSSPRGGKSGDGAVGATPRGRPGAPPLHENVHGAANTWIFSDESKIVLHSSILVNYDKPASTVVTLTPEQVEQLKRALEARAVTFAAQQRADNKIKALEDDLESLRGVLADALQDLADAKATGAAHDAELAAKDREIDDAKAAAAATAKSADTNRTGLLPAEELADQCRELDGLKATLKNERRTSKKSSDKKNGNTQRDEAKVVLEERTQSGTAPNGDMPALLHVGDDRMASKIIDRLKKEIRILRSESGAASAVLDGVRDTINGCPELKQCLEEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXX1</accession>
    <name>A0A088RXX1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 19">Leishmanolysin</fullName>
            <ecNumber evidence="5 19">3.4.24.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">LPMP_311850</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Has an integral role during the infection of macrophages in the mammalian host.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>Preference for hydrophobic residues at P1 and P1' and basic residues at P2' and P3'. A model nonapeptide is cleaved at -Ala-Tyr-|-Leu-Lys-Lys-.</text>
            <dbReference type="EC" id="3.4.24.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18 19">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="18 19">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the peptidase M8 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.36" evidence="5 19"/>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701576.1">
        <property type="nucleotide sequence ID" value="XM_010703274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXX1"/>
    <dbReference type="SMR" id="A0A088RXX1"/>
    <dbReference type="MEROPS" id="M08.001"/>
    <dbReference type="GeneID" id="22577611"/>
    <dbReference type="KEGG" id="lpan:LPMP_311850"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310025300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_311850"/>
    <dbReference type="eggNOG" id="KOG2556">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="527990at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.170.20:FF:000005">
        <property type="entry name" value="MSP-A1 surface protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.132.10">
        <property type="entry name" value="Leishmanolysin , domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.55.10">
        <property type="entry name" value="Leishmanolysin domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.34.10">
        <property type="entry name" value="Leishmanolysin domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001577">
        <property type="entry name" value="Peptidase_M8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10942">
        <property type="entry name" value="LEISHMANOLYSIN-LIKE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10942:SF0">
        <property type="entry name" value="LEISHMANOLYSIN-LIKE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01457">
        <property type="entry name" value="Peptidase_M8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 19 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 18 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 18 19" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 19" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="10 18 19" id="KW-0862">Zinc</keyword>
    <keyword evidence="14" id="KW-0865">Zymogen</keyword>
    <feature type="active site" evidence="17">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601577-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR601577-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU366077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="AIO00776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="648" mass="67783" checksum="EA3BCBEE1BC73AC1" modified="2014-11-26" version="1">MSRVPVASWRLGLWLGALFMYIAFTTAAIASSALKVDSNAADELPSPCGHGQVVSEQSDLPLTYVTLRRNSNGLRYQVEVNLKRLNASATTDQRAVEPRAAVTVSSDSMDSGWAPIRIAVFTPDLEDQSKYCTAVGQMRPDSSGSLVRCSSVADLLTDAKKRTLISSILPQAVSMHAQRLKVRPPAADTTIVVNTMPGSHCGSFTVPPAHRTVGVPDADFVVYVAAGPTSTPRSFMAWAVTCQYYPNTATITSRPAVGAVYFNPRYLPTSIGETQEEIDLYGGSPFGSTNGLRRAAAHELLHALGFTSAVFKARGMFATVPSLRGKKNVPVLNSSAVRVAAKAKYGISDTDMLYGVELEDQGAAGTSLSHWKRRAAKDELMAPVLSLARYSSLSLAAMEDMGFYKVNFSQAEPVALGATAGGALFTEPCLTGGTTNTPTVFCDSRSSSARSCTADRLSIGQCALTTYSSALPSYAQYFPSQPTLGGSLSHSDYCPVIQPLSNTGCGGGSLGAMPGSVTGGNARCFDADDLVVKSPFTNVGAICAKVHCNNASRTYAVLVSGASIWLSCGGGGTGVTVQPAVSSPGMFMKRGTIACPPYDDVCYANPLAFAEVEVITTAAPSNAATAATHGRVTSGLVAVAALLAAWVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYB6</accession>
    <name>A0A088RYB6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Dynein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_321130</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein intermediate chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO00999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701799.1">
        <property type="nucleotide sequence ID" value="XM_010703497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYB6"/>
    <dbReference type="GeneID" id="22577854"/>
    <dbReference type="KEGG" id="lpan:LPMP_321130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320016600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_321130"/>
    <dbReference type="eggNOG" id="KOG1587">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="366230at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036157">
        <property type="term" value="C:outer dynein arm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036158">
        <property type="term" value="P:outer dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000745">
        <property type="entry name" value="Dynein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001805">
        <property type="entry name" value="Putative dynein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF7">
        <property type="entry name" value="DYNEIN AXONEMAL INTERMEDIATE CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0243">Dynein</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="261"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIO00999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="601" mass="68021" checksum="20FFBE310DEEC96E" modified="2014-11-26" version="1">MTEITYSYSRPAREFGRMPEFQANDSEILADIAPNDMIKDKFTLQNPKESQVQNVPQLSEASTNTESVRIKNHAQYHGEGGWPHAVDPTEFEEKMKYCKKVEREEGYLQTCGRLAEQCVERCVKQNTALDIYGQYFPDAPPDEEETMGPASLKVWAVLKDPSEEKRTAAALSWQNDGRRIAVAYARLKFQSQTPTMSTNSHIWDLMNPNDPAETLVTPSPLCSIEYYSKDPHLIAGGSWNGVVQFWDTRQPNRPAARSLIEESHKDPVWALKWLQSKSGELLSVSTDGNVFVWDCRLPEKPMTIRSISEDNLVLQPRSNDGGARGILGGLCLDYDPQVGGPAKYMIGTEQGTILSCNRKGKTQHEKLLPNTFNGHHGPIYSVQRNPMFSKYFLSVGDWTARLWFEDFKFMPMFSTFYHKAYLTCGVWHTVRPGVFFTTRMDGYVDVWDLMLRQTTPSLSFQVSDYALHTIKPSQNGNYVATGGIDGNVSLMELSPSLCTMVPDEKNVIGTLFENESLRDKNLDRALKEKRAMARQRERRSTHLAGITRAPTKEEAALDDVAAKYMEEVSTVKAKDTHTSDETDAQRLKVLEDLEDGMELYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYJ9</accession>
    <name>A0A088RYJ9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tubulin--tyrosine ligase</fullName>
            <ecNumber evidence="11">6.3.2.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LPMP_323080</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine + ATP = C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17605"/>
            <dbReference type="Rhea" id="RHEA-COMP:16434"/>
            <dbReference type="Rhea" id="RHEA-COMP:16435"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:149554"/>
            <dbReference type="ChEBI" id="CHEBI:149555"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the tubulin--tyrosine ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.25" evidence="11"/>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701993.1">
        <property type="nucleotide sequence ID" value="XM_010703691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYJ9"/>
    <dbReference type="GeneID" id="22578049"/>
    <dbReference type="KEGG" id="lpan:LPMP_323080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320037200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_323080"/>
    <dbReference type="eggNOG" id="KOG2157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18862at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004835">
        <property type="term" value="F:tubulin-tyrosine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052492">
        <property type="entry name" value="Tubulin-tyrosine_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46570">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46570:SF1">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0630">Potassium</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIO01193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="638" mass="71452" checksum="B32FE77D8F522D66" modified="2014-11-26" version="1">MIASVSERRNTRAPASAAPKMNMQYSRMTSVKASSITYGKKEAEKDVLLATSPYSAMSGRGASNGASLSSARRSLVFPGTASLSSPTLRHTSKIARSSSLTGDAAWSSGLCIGSAPERAATAPLQRTKSATSTEKRCKYVVGTMRNCGSIYEEMTKQLLATGRWSHLSVRQCSITKALVVSETQKDLSDTNMHLLLGEKMPCERVIATRRVMSKRYQGHLGKGSRRRHFVYASRFYTSPGLRIPMGSGDDGEVRVVDFVENTRSITLKSSMVTALLKYHNYNWNTLGDYLPMSFKLLPCQSSRDERQQLLATAKNGVRLPNQASKPCMWIVKSSAGCHGDNIEIFPGDYRGILKLLRFIDSQHDNHAWIAQQYVDRPLLYHKRKFDIRCWALLLRDLYEIYVHEELVMRTSSVPYTRESATSKTPIGRLAHITNHCVQETGKMYSLYEESNELWREHLDGLIRYKGTVRAAKLKQEKCTPLCGLRIQEPKHCDAPYPTTSSNDVRESPYPIREMNHNVSTPTPHPVSAHAESTSITLDSHIMPQIHFIIRDSLLAARAHVPDEPAVPPTHTFQVFGYDFLIDEDLKVWLLEINGAPGGPDRLKPALVKDTIELAVAPYFSGTMNLKAKRHNGYVRIYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYW6</accession>
    <name>A0A088RYW6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Adenosine monophosphate deaminase-like protein</fullName>
            <ecNumber evidence="3">3.5.4.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_322690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.6" evidence="3"/>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701954.1">
        <property type="nucleotide sequence ID" value="XM_010703652.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22578010"/>
    <dbReference type="KEGG" id="lpan:LPMP_322690"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320033100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_322690"/>
    <dbReference type="eggNOG" id="KOG1096">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1723809at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003876">
        <property type="term" value="F:AMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.20:FF:000005">
        <property type="entry name" value="Adenosine monophosphate deaminase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000035">
        <property type="entry name" value="Probable amp deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.20:FF:000003">
        <property type="entry name" value="Putative adenosine monophosphate deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006329">
        <property type="entry name" value="AMPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359:SF6">
        <property type="entry name" value="DEAMINASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19326">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1394"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1572"/>
            <end position="1605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1605" mass="178456" checksum="CD417777A4500743" modified="2014-11-26" version="1">MESKTHIQPKVRGGATSVIARLLCHKFPQQCHPSISSSFVSFGGPGELPGPNDGDTVQGRIHGRDAMEVSETAVAPTYHRIMIDGDEGDKDYLNCVGVIAHIIQTRQAYKDTDQGQLEIPLTTEELERRYCSTAAAATSSVSAASRTASLSFLPSLSVAETPEHQPPQSDDSTAMASLMGLEFRHGVFVFEGMRTRVVPWEQYVHDIRAVYGAIENGPCLSTARMRLTSIAEKFRLYLLLNRENEGSCDALYRDGGVYAPCTRVDNGVNMHTSVVAPVLLEHVVTTALEQPRVPLYVDPHTQQVVTLGAYLEAGGIRDPRALTVEGLGLQPTLYRNKYLPYDLFDAKLNPAGAFGATLLQALLSTDGPNHGNLCGVLLRAELEQREYQKQQLTATEMALEVCGHHPEELTRLAAWVRRQGFNKFSRNRWVLVIQRERNSAKELGPNQLPSRCTTVGDQLRHIFYPLFMATLCPYAPQWSDVAQLLCCIGAIGIRTHAVVRSENFSATPVDPDTLPCNSAPRESGQVVDHGGAVAHGGGCSDYYFFYYVWANMVALNALRKRLGLNTLLFTPSVKEQAPAYDQLVSSFLLGDVVHDVSSLAKSWIMQFLYMYCRIGIVLSPLRDNALSTAYFNSPFLKFFRQGMRVSVSTSDPLYFHHHESQPLIEEYATLSKLCSLTPMDTMELGRNSVLNSSFPSEMKQAWLGEGFSSLGAESNDLRRCGVCDYRLQFRHEALAHEEALLNQLLAKAGIMAPGGIGSGVAAGDSAGVALSLHLIPYAQSVLVSDLVQQSRHSRRMNYTDQRIVYPRIDIYYGGHRSGHATDAVAALRQVVGLRRKYVGNASHTAATDTNVRVEDVFSTTRQFDEAQWEYNTYYGVCILSQQGRTPSWPTFLPTITEFIRDMSVIRQAASSVALQRLATHRLNLLEQKFLLHLSMNVSNEAGKKEEKEWNNRDFFTAYKVDTNVHTDAGSNARTLLEFFVDKALNHGGDVVFERDHHPVMLKELLSEYEIDVHHITVDELHHHLHTHTDLREIFLSPFNFMQGRYFAELTKRTLDIYEEDAFSFAENRLSITGASAQEWYDLAHWFDCYGMASSRSRWMVCLPWQYRRLRRNGVLKNFGEFLDHVFHPLWEISLHPAKDTKFHYLLAHLSGFDCVSDESKIDLPLTDVSPHDWNSDLNPPYSYYMYYMWANITSLNEFRASRGLSTFTLRPQCGERGSMNHLVSGFCLANSINHGVTLARHPVLEYMWYIAQVGVAMSPLSNTAGASAYLENPFPVFFHRGLNVSLATNQPLYFHFTREPLVEEYSIAAKLWKFELNDMSEIARNSVLQSGFSAAWKQNALGPRYQLRSTLGNDVRRSRVSDIRVAYRYEVYHTELNFLDEQLTAGSPGFVGNASLSESAPTSAGVDASRGQKPRRFDGASTVSPTPGGGPAAGAESSQRMPRAMKLLEDELVICGDAAVADIFQGLVSTALLPTSAPNVDNSLAWPRTANSRGVHQFLPSSPAPLPAQLESRAAQLRGEIQRLDAELTRMRVVSLQVAGQNNSIALQVNALRERLQTEGLAIVGSLYGGTNEEETEASSNDGFPVTGVAAAEEETVGGDVRKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYY3</accession>
    <name>A0A088RYY3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_322940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701979.1">
        <property type="nucleotide sequence ID" value="XM_010703677.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22578035"/>
    <dbReference type="KEGG" id="lpan:LPMP_322940"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320035800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_322940"/>
    <dbReference type="eggNOG" id="ENOG502R9GN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10046650at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="CDD" id="cd22541">
        <property type="entry name" value="SP5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35313">
        <property type="entry name" value="NO EXINE FORMATION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35313:SF1">
        <property type="entry name" value="NO EXINE FORMATION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="490"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="520"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="600"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="647"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="696"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="734"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="789"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="815"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="857"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="900"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="936"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="969"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1012"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1038"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1063"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1088"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1139"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1178"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1208"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1235"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1305"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1360" mass="149029" checksum="ECF83482FE55CEA9" modified="2014-11-26" version="1">MSHSSGPTVPTPSPDGAVAELQPHSQGSPPVFIHPPRPHAAPSAYPSYPPALYPRQLQPQPSYSPSLPMDTHDPNRSSVGSHTAPAASSLMLSGSYGAAAVTCPSPAYPAPPGSSGYGRYSQQPPVAPPPPTHEQQNPMVYIPREVGREEVVNEAIASTSQYRSQTQLRQEAEWCYERLCGNVPQSGHRGREGQRCDGYARENVARHLLTADRAAARGGTVPSVSSRTAQLQNVEFLIGSPCHVNRLVLLFFSTLFGVLPLMSTFAFTTLLCGVVLLYISDYLGYHRTTVFVLLGTAIVFSATLFFSNIHAAATSFGPMLMIADLGGILMVVVAAAIQHFRWVQETFPNVLCSLERLVFAVGPVLCLPPLLTTITGLAGSRYAPFFFFAALCTLHRFFYCPLKSSFLVLVSPKSAAGAATASVQQHHQQSDAAGDAGVHARRRVVDNGNGEAKGAHVGVGSVGANDDAALVDTSSPTHGVPLQLNEQVEAVLFSCLVVLLPIAVYNAFQSNWDDHVFANILNSLGLVCGSIAYFCISPMHSLWFLASPGENTYSLFQQLEYDPVKLLDLVTTFRIPVLASASTLAVHWGAYRLLSSRYSYLFSGVAYPFNAILLLIAFYITVYVGIEIKRLLDIDSSGGDVMKDKHLIRRMPVLLGSCVVSVILCILTSMPGVLYFPSVLSVIAFNLFLMDRTSGGPMFTFTVFTSLMLLWWMYRTYSFIVMDLRVFGETTVVPTPVLGVSVLWCYVLGCMGFTLSFSPSKMPVTIVLFLLALQVTFVEHVLYSQKEEGVYPGVLVALTSVVGVAVMCRMYANGVLTVYSAALISSCYVAKFFTFLVEVTSAGYAAELAVRDGLETVRAGLLTVELTCGWWVVLFAGYLVATFEIEHRRRIKMEAAKRMLYTYAALALLLSLLTIRNVQRAAYEFVTHSYVAESELLHIAAGTCCATYALLTMPVWWRLKSRYPVVFPLYAVSRGTALLAVVLLAVQPTRVIEDEVSNLDYDFEYADRGRCATAVGLIMLLGTRVFSLPCFPFAGRFLYWLVAAASLALGITGLVQAAPSFNFYIMMLGLVFLALIMVDVAHYREVGGFVLIGVYGLSILMIPLSFLQLNQFVSEQQEKLHYSSDRLTTLWDMHEQGSMRLLAVIIVVHLGLSVMINCRLSGRPLLPKCQVISREASLSLGVIANFSTELSVMLLCAINFYGNDSDPALYVLFSLLLLLFVDDELIFFELKEHNFRYFAPVACALTLLWLCTMWNAWLTAAPHGLLSQLRRETWAVVQASFTLPAQISLLSLLWKGRKMGSSPGFVVIGSVLLNLACLLLVSDKAVQWMAIVGIFGQCVRIFEAQLQPTTSTRRRHSSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZ95</accession>
    <name>A0A088RZ95_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histone-lysine N-methyltransferase, H3 lysine-79 specific</fullName>
            <ecNumber evidence="1">2.1.1.360</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Histone H3-K79 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_331870</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60328"/>
            <dbReference type="Rhea" id="RHEA-COMP:15549"/>
            <dbReference type="Rhea" id="RHEA-COMP:15552"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.360"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.360" evidence="1"/>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702278.1">
        <property type="nucleotide sequence ID" value="XM_010703976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZ95"/>
    <dbReference type="GeneID" id="22578340"/>
    <dbReference type="KEGG" id="lpan:LPMP_331870"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330025800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_331870"/>
    <dbReference type="eggNOG" id="ENOG502SCMW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="443402at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140956">
        <property type="term" value="F:histone H3K79 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025789">
        <property type="entry name" value="DOT1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030445">
        <property type="entry name" value="H3-K79_meTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21451">
        <property type="entry name" value="HISTONE H3 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21451:SF23">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08123">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DOT1" evidence="6">
        <location>
            <begin position="99"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO01478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="253" mass="28640" checksum="058D5F2D787CD376" modified="2014-11-26" version="1">MNYLRHHSIAANYRLLGLTPPPPNFAVMQPLLYKHLSEEYKNRGELELGEESLTVQPNVFAQIGIIDVNGVRQMWTKAIIPALLDWRQRELLKSEGESQADLEAKVVFCDIGSGVGNVCLQVLSETKCPKSVGVEIIPSRIRAAEEASKRAKLLYSDIFSKKEAVWVQKDLIKCAARLKEEGVTVVFTHSWMFDNDLMTKLTEVIAQVPSIQCVVTSRKLDEKVLASTMLRQRTLMHFSADWNDEAPFYIYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZK9</accession>
    <name>A0A088RZK9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Microfilament motor protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_311170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701505.1">
        <property type="nucleotide sequence ID" value="XM_010703203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZK9"/>
    <dbReference type="GeneID" id="22577543"/>
    <dbReference type="KEGG" id="lpan:LPMP_311170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310018900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_311170"/>
    <dbReference type="eggNOG" id="ENOG502SHXW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266181at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF80">
        <property type="entry name" value="GRIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="332"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="486"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="611"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="692"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="531"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="978"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="486"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="506"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="616"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="692"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1074" mass="115775" checksum="90A287582DF04293" modified="2014-11-26" version="1">MPPPLATGAPAKAAIKAHRAVAFFTSADGSHCLVGMVASTPTITQSDGTIAVLVQPRPLILVAPQRQQDASKNGGLVTGHLVSASDPCVGGLITTAISSPRHAKGNSSAAPSLNVDDVGTVMPVEELREMLEHRDILKEDLGSSKARVRAIDELLRDHTQQKHSSATAASAPNPLQAPPPLKEHLHAARKTVDVAAKAARIAEKELLLARAGLRTVKPLAWIDLQRRRSVSSSQLLVSLIETAVAPLHDRMCASFDDVVMQAASLPKRLAAVKPMSVTVDDAQRTLRFLKAWPAVAAVEKEHKTAAALYRWVVALTKAAEAQQHLSAAQKALAETASQSPGAARQSKAMARSSEPLSQPPQKLGSVAEAALRKERRDYIEYVQMAEDELAALDALIAEAEALTTSSCPNAQDSPEGAKTIVPALVVPASWVVCALPVEEAPLIEACTHQPLGKSVEFSSSASLMLSSVTKPQDLIVPELSLAEMHKESSVSEKKSNGYRGTGVNQSTSSPRTAATAPTGAENAALVSVTEIAAARKRAEDAEEKTRLLEARLSAALQQNPREMEVQLLRDELDAKRTELHRVTEERDRLLQERCERSSRYASNAWRSMADGAYGDDTSQSGSGQCVQQPSTPRDTVDRSVVEELEDQLTAAHQRISELLIEVGESSCRPSTLAALFAAQRVVKSGCVTSAQGDRSHISVRQSPSAEGINSTPHSTSGTPWQRSPRGTVVSPGRLPSLPTITPDMYDDLQARLCAVSAELEAQRQGTHRLEEQLNDALHRKGEAEQIVSAQQHELEEVWEKLEAAEARAEEQHLLTQQRLFLTQAQYFPSQSHLSQPHMLTPLSSSSTMANTNFSQTQKPLLTSASSPTPHTHLALSVQDAFTNDSTLGAADAEIRSQVDEDAMTAVTNANTACGSASPLSMDVYSHSLRSGVFPTFGGGSGGVAAVAAAATAADPSVASPYSRGPSALQSRPVEKLSMIELRHEVHRLREEMERYQSGELRMAMELQTLREKQKAERKRRRDARAARMQMLVRMQGNIAGVIERSTNELEAIPVLLERCRAEAEALMETRRMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZV4</accession>
    <name>A0A088RZV4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TerD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_312420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701630.1">
        <property type="nucleotide sequence ID" value="XM_010703328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZV4"/>
    <dbReference type="GeneID" id="22577668"/>
    <dbReference type="KEGG" id="lpan:LPMP_312420"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310031600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_312420"/>
    <dbReference type="eggNOG" id="ENOG502RTY0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="443958at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.30">
        <property type="entry name" value="sav2460 like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051324">
        <property type="entry name" value="Stress/Tellurium_Resist"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32097">
        <property type="entry name" value="CAMP-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32097:SF17">
        <property type="entry name" value="CAMP-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="906" mass="101387" checksum="94632B87699A56B1" modified="2014-11-26" version="1">MSYSDVRQKVFRVPGNIVLSVGLSWDFVGADPVDLDLSAVCFTKEGRFLDVVFFNHLFPEGTNVTALQEHYMVDPALLPYMFLSGDSTVGGEDENQHPGLALAARRCHQQRRRRADPHAATTGGMLGTRDYTNAAANVFNRLYEEEQLADVQRAADEAIGYDKHAGDDELGEGQRPSRRRQRHHRELADEVLTLVMSKIPQEADVIFLSVSSYTGQDFTVLSRAKLIIYNESTNERVGVMDLRLTTENGTANLAAMLIRVPAPQEEGVAGVDGDGSLGSAAAQEWDLRELNVRTFGYSFVDTLPLMMDVLGVPRQSLLDVLQNLPDYSLSKAKAEIAPSRLSDVRFGVGWSSEHDIDAFLVFLDENNNYVDHLYPKNGKLRSIARDAARHSGDALCGSTSAGDEEFIDLLTYRVPDNVGSIVVGAVWMESFGAAKRTCNSIFDVPDLYLRLQNRTVMNPHSMEVDRWLVNREAHDQKITKRLPTTYKDAEHREQPVRAVVLGALMKTGTQSFDSLFPNGRRIDQHFRTHRPPLSEGDDGAVSELEADCEEEVPLFQLVPIHQYVPVDPRDGFARMIPYLQCMVAYAATIERDILTAVHCRGAEDEAARLGIATPYSVLGSSGVSALNTTTGTKDTRLALSSEHNMVGWNPVTSASVRRANRDETATKAARERDAKDKAATTALRNRYGRMWSEMKYYDNRTDLFAIAVQFLEVVEVHPQMPDRFQCHGEVWVFGQTNCIVPAHGRVSALDNKPYRSPILVDREKLVWADAHQGSSSCGYFIVHKYDRLRVMLFETASVGVADLDLLSMNALWNSEGDERLTSLSDRFNPIECSVQLTGGSSVMDTGMLVYRGEVRLRVSRVPLNAAMIALQRQADKLNAQHRHVHELQKRYEERYYNKQYQPCVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZY5</accession>
    <name>A0A088RZY5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nucleoporin (NUP54/57), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_312760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701660.1">
        <property type="nucleotide sequence ID" value="XM_010703358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZY5"/>
    <dbReference type="GeneID" id="22577702"/>
    <dbReference type="KEGG" id="lpan:LPMP_312760"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000022800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_312760"/>
    <dbReference type="eggNOG" id="KOG3091">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6162375at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024864">
        <property type="entry name" value="Nup54/Nup57/Nup44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025712">
        <property type="entry name" value="Nup54_alpha-helical_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13000">
        <property type="entry name" value="NUCLEOPORIN P54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13000:SF0">
        <property type="entry name" value="NUCLEOPORIN P54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13874">
        <property type="entry name" value="Nup54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup54 alpha-helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO00860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="462" mass="48785" checksum="1C28E320CD34E2D3" modified="2014-11-26" version="1">MFGATAPSTVIGAPVAGFGKAPATFGTTTLTGTNTTAPTGGGFGSKTGTSTTPGFGTAFAAPMSSAAPVFSATPAGGAAGFGSGSASGTTAPGGAAGVGTCGFRAGGGFGAKSGGGFGTHATSGFGAPATAGIGFGSGAAAPAATGGWGMQQPNPTMQPQAPQQQQATVHLLQPTVTLQDFTRQSALASYLVKLDESYNALHPNCHFRAFVYNTCGAGQAMDAIQKERYTAYLNGGGCSDEAYMQALQKSPDPGRLYPSPIHFSQELRRRTEKQREAVKVLQRKAAELLQDVDTVAGMDAANVRRQREVEQQEVMLLHRWYSLLCKMELLRRHGSSYGEESLLNSRVEQLRQLLRAPGRYSQLLGELRPFLTEEASRVAMVAQQSANKSEARQQQPGFIGAAPAVWRSADGQPLLRSEVDPYMMRDWIQFTKQMQDGIEALDELLKTDLKEMQAIRSRVEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZY7</accession>
    <name>A0A088RZY7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_332780</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702369.1">
        <property type="nucleotide sequence ID" value="XM_010704067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZY7"/>
    <dbReference type="GeneID" id="22578431"/>
    <dbReference type="KEGG" id="lpan:LPMP_332780"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330035700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_332780"/>
    <dbReference type="eggNOG" id="ENOG502RMCY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273500at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="1025"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="690"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="776"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1080"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="694"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="781"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1092"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1117"/>
            <end position="1126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO01569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1150" mass="123240" checksum="C58728FB33F6737C" modified="2014-11-26" version="1">MTSRIPLPLRLVQCNLRAATANGRSGAGSRVMTAYKPSGLPCYAASQVRAVAASGGDGRRLCAIHVRQTSSASFSAAVVEAGPQPHPEDPSDSLLARVVDAALPGCTPYVALPVISSLLRRGGHGTAAAAQLNQWTCRHKGLVVVTGTPSDALFLRNAAQLGLVQQAYRVLCHLPAGVAPAARRYLRAHHSCTQPQQASEGVSTSIGMHNRYVQAHLEQRRRRQQLADISIGIPLSAESLPGTTKVRAALASTLVCDARLPASVHPHPLVSEGFFDVARGQLRVQGTVKCYVRTQAPLATSSAARVHQRSRLQSLFLAPAADTTRHGIKASSPEEVMCESRHPWMQPLWRLGVSLDAPHMECEMAAEDGGNGDRPRRASVQAPRGKSLSMEVRLVSLSPRDDSDVALYEVHTHGDTTADEVAAVFQAEGLRVVNDYVQDVPLAMAVEEVATRMRAAPPSLLHELPLGLQHRLHSATAEELVALPLTRIPLEDADCLSVQHTLLQLSALSPPLSFAEDVERLRQVVLTAASSAGGNTRHPLQHLLLHALSSLKLTNEAEQRVYQQVLTLALGTGIECTGVVFPDPSDEGNVHALQQLWLTYENQRQRHPSLADAARAARQHPLASSLRYTTRSLLDDPAGLTRVPLLADMALGTTSEVATAPSCAHGRSSDILGARGECSFTQAVELLRSSAHSQTEEDGHGISGDEARDATASAPPSMNGTVTRWMQTEVPPAYKRAFQEWCAASVVPSCCTDTTSPAAGVGSLLPSPTSLLSHCNVPDTSAERGSELAAKDPSSSDEGCHPAVPPWRAPLEHIGLPVRVFLRVEELAELRCAHCDGVGHTWHHCGARVAEAAHVLEGDDAVAKSLPLPVGNTSAADALTCLETMPGPLENSVMDSEGLTSTGDAAAVLAEQANALVRRRQRQQQHLVGIGYGDDASASLSASSSPFLVDSPLIAVPNVAATHRFKASHVLLSESRKPALHRRVMRCVYCGGRHHVTVCPTLRSQDSESEARRVHAAAGALPFFCIKCGQTGHLYTLCRDIPAGLHHATHCPICLQTRTSASHDPVHCPRRVSVPEGYRLNGIPEAKDSQTQHEPSSWRPSARSQRHSEGTIPLTADRQRCHDSRHVGGASYRRRRRGSVLIADSYVDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S021</accession>
    <name>A0A088S021_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_333090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702399.1">
        <property type="nucleotide sequence ID" value="XM_010704097.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22578462"/>
    <dbReference type="KEGG" id="lpan:LPMP_333090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330039000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_333090"/>
    <dbReference type="eggNOG" id="ENOG502SH4J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265587at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35615:SF7">
        <property type="entry name" value="PRESENT IN THE OUTER MITOCHONDRIAL MEMBRANE PROTEOME 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35615">
        <property type="entry name" value="PRESENT IN THE OUTER MITOCHONDRIAL MEMBRANE PROTEOME 22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="684"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="851"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1033"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1209"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="690"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="857"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="878"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1209"/>
            <end position="1220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1577" mass="170401" checksum="151425E033066576" modified="2014-11-26" version="1">MSGTSTAEARDHWMETATRPRSKGAPPPLQQNSDEGQLQPARTLVEAVECFANEQYFGLSLAQGNEDGDARSNSPVSFCRSDNTEETRRHAQHNCRQSASANTKRGTRDEDAVYSEAVSSVCSSYFSRHNTLTEITHERIMAQRLSEKFYDISTFWPPDSQTSERAGDTEEQLFPAFGIEGAAPPSLVQPATRMMRARAETVATSPPSRLLAEFDDLYHVLSMPIAGAVQPSSHAGSDRDSIGGGSHFTRRAPQQDIHYLNTSVFTLFPDAPASTFARQQRDCAASRSGSASVDSSCDWVVAPESWEYGEWMLTLQPAMREALSVHSTGTMVLATSDERRSAEFTNPTATNVAAEPSNRPLLTTADYFPRTAHPKAVWNERQVGTCITTKAQCAPSTFASRLSRGVTDNDVSSQAKARPLVEVCNSAATTAPPPLDTSTATDVCITMKEVETGATTPIRSVADDSSVVDVALRQLSEPLSHHYSSGFAENIFVRRCCRASDGGAPSSEVSTFLEARSARQQPPRRPSYANSTRSVAFKAHTTTPAMSNGLLDGHQLAFTTTTTARGVTAPWLLNKSAGTVTTASVNRPAAVLIANAAPLLPSIVPPIRRTADAPLRVPSPVAPISSTATLHVLSPQTIAAVGQHTLTSYAGQPPEVLRALGRHRRRLALLPGPDNVATECLSGVPRQTKSHSTSATAIGATSSTTSTSSGDLTSSSSPQRACAEFSEPQQPFLGAEPYPDAMDDNLVIHCEWRKRMACSSQTSPADCGTCSSAAVGRSRLYMGVASSHSTASTPTATASPTAAPMTSPFATSCGLPAEEGAAHATEDVSCLSPQANEGAQQQLLKKLPLDSRDEGQTSSPVISTSLSSPLVTARKATPPREEVHDHGPASSQESGKGAVDPTRSQSDRRRRMGLKENVEVVLPDCKSLRVSMSSWLEFHNPTMREQGKEMMPSAEEVYTHLMMRSNALCALVVVDEDAVRKPCLVVSGLSVRVYEEDKAVSLANGRMAHGVRRALRTSCGGTYSRFLCSSSYADEEDTSGSDDSGVGIRGGVGMSNRAMSSSGGGLPSNLKSFVLLPDKKERLNKSGEVHSTNSRPGEFDKYLHKFDLDETLSRLAGRKECHSVALEMLMRTWVTGHNTCLLLGNGNGRSTHSLDVTVGAVENAMIMLRERLHDSASRVELHICMGDVADDEDNSGVAVLDLLACSSDGDDNDDSGDAEEFEKGVRRQRKGASPAALKRGPPRSSVQLARSPLFGTVVKGLRSVKIDDATAETGAIGRLLTLGFLRLNISTHSSRRKSVPNQSTLSNAALSKVHTSFATLRLKTICRGADMRSARLSAWESTTSDKRFGCQERHSHSVEYKADVLVSSLLLVYFGTEYMVLDTLVQRSHAYRMPTREEDEGFVHPNAPIRHQKPDFLPSRWPNAVGFLESLVGDALGGRTRTLVCLCLSEYDSRATLWLRAVSRARRITNVTPNCGNVRNFLVYLLEQYDSLAALSAKATTRHRQRRRHSTASSSKEFSQWSVHCVRNMIDELDAFLATPTGDTPSLERLEIANEMIASAPPDLLTNLPLCVFSQNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S059</accession>
    <name>A0A088S059_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-alanyl-glycyl endopeptidase-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_332950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702386.1">
        <property type="nucleotide sequence ID" value="XM_010704084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S059"/>
    <dbReference type="GeneID" id="22578448"/>
    <dbReference type="KEGG" id="lpan:LPMP_332950"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330037500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_332950"/>
    <dbReference type="eggNOG" id="ENOG502S2KT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="299748at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007921">
        <property type="entry name" value="CHAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051705">
        <property type="entry name" value="Gsp_Synthetase/Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30094">
        <property type="entry name" value="BIFUNCTIONAL GLUTATHIONYLSPERMIDINE SYNTHETASE/AMIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30094:SF14">
        <property type="entry name" value="D-ALANYL-GLYCYL ENDOPEPTIDASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05257">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50911">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C51" evidence="2">
        <location>
            <begin position="163"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="334" mass="37000" checksum="8CF9DC2561CEDF1C" modified="2014-11-26" version="1">MGGATRFVSSGASTADDDVVVRHSRRYGGATIQRSTSCEIDNERTLFVQQENKRTDSGVACLGAVRRFVLTRDPLLYGLLKWGLSVLLLLFLTVVLIGLFFSVFFYRGNCENTNGTTKEKTDPKQVCVTPFATILGIYDGVFGYSNCNDDYTSTKYRYVNLMVPVLNNETGKVVYTSKSFFTGLEWQCVEFARRFWMLSGKPEGAYFDSVVGAADIWNLSFVRLVSNTSATLPLQKYSNGGRLSDGLQAPVPGDIIIYPVQGGGFPYGHVAVITKVDMAVNGAIYVAEQNWGSAMWVDPHHNYSRKIPLMYDMTTSSVTLNDPNGTIIGWMRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0K0</accession>
    <name>A0A088S0K0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Concanavalin A-like lectin/glucanase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_341470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702574.1">
        <property type="nucleotide sequence ID" value="XM_010704272.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22578652"/>
    <dbReference type="KEGG" id="lpan:LPMP_341470"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340020700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_341470"/>
    <dbReference type="eggNOG" id="ENOG502RPKQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272104at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1045"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1299"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1895"/>
            <end position="1917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="317"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="440"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1063"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1306"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1898"/>
            <end position="1909"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1946" mass="212946" checksum="4675BBA8D2AC627B" modified="2014-11-26" version="1">MFSKENFIDLAHQAVSAVRRIVGSSEARGVRDQLSATSRVVVTVCKSNTTVDAVTLEVWVNDLVHELELQLMQSAAVIETATAGEAVVASSSIKEEASRPLSEPALIENLEVARALMYSCNAEEAAKVYLKKKLVAALVQLYSNATLTQKLRGCCANVIVGVCSSQQMLLRDFMLVCTNHLRLPPQDHNGHVLRILIASLLVEVLHQFQMRYYGWLKTDLDAETTAHCASLIDCLFEVSYSLMVENVAAASRTETASRTTSYEAEESLTSASPSPMPAPHEETPAPTAAASTKDGNSCEKTVPPTTPVTTIAGNSDATASLPASTSSSAPANSESLNLTTSVVFLAVVAGVYRARPALKTYLVCHYSAEYAQVWVKVASCLTKMRTNLFLSLSSRSPVSIMLESMEYWRAEMLEGLVELCTTDSFTIQRATVMASIAESTTSDGSSSSETNQKGLVPSTKASLRSAAHVTASLSSGTTAAPAGSGLSLSSGGRYQFVPIPADWATYLSRSSSAVWRLASALFPCTVTSEGINILKAVLLMLNTRHASAEALYRSTISTLTLLCVANPRNAVLLSEHHFLLTIMALVNCNQLSVFPASQQVTLHFRHGEPSSSSPMAAQTQTLTLTPPNTLNVNTTQLTFCLLNTLTSTTFSKATVKLLMQGIKDMCSMPSSQTDVDIIENFLYGLGHAFIPHPLLFFPGDGYVSWRLKHMFPRGSGYSFTAWVYPTCVWTGGSCLYSFMDPSDTRVSLLIVADGRQCSLAVRVNKAGGEPTELLLSSGTFSTSTWTHVVVNHGVALNVYINGEHIEGVHVVPYPKEKHSIMFNIGGAVQLPGFLGFMSGMNISATLSEKEIAKLHASGPASYDPSRDCASFLKPFFEDQSSFPTDLQTPPAPLSLHQNDMITKKSAEFRWNHIELYVPTDIEELIAPSKVAEWVLGILRHRRTASMQNTSTFMNVAKLSISLLSTSMQLSTTEQLTQLVLKSYLNRLRTEVLSWRGTFPEFASLMLQSVSQRGGGKALHHHACTQRVFDLLLSCVLRPSAHGNSVAHHRVNVSRDPLDPSDESATGSTAASAASSPRYTAAQEANATNIILRELSDCLLVKENKEMFQEDSSRFESILSVSLRLPKECIKSVVILIEKLCRSEAELRQVLLFLLTPSSVSPIADTAKVWVLRMLFDIAREENTMREMIQECFKGRGVMFIMLLINGENHSSEAIRLLALGLLSLLMPLKACTKLFKKNDGFDILSLALTEPRNDIPIGIRTFDALFHVAFDEFRRHREKKPEADSIASRLMATAHILHRQKQRDPSLSATAGGGSKSSTSVTLAGLLQQSRVQRRIADHLGHTPSIMVNHLGTRRGYSFEHTHDYGRVSEDFGELVLLHKGSGYHNLHLPLALKTVLCVLDYLIRVVVHRLCSDSPLVISSAAAATVTAFSGSNVASSSTDYLTATEEYPTLPTQSQENGALGMTTRAAQMDDERVVVEVLNYLEKLIEWPKHALKVMDIPWLSGLWAAVRVLFEKPVDLNGTTGVVTPVRFPEPETMFTAPAVAGRGRPLSLATLQPSEASIRRLHHYRSEFVAEVTKHCRAIIRKMVILDISMNERAQIRSIRDGEHPPRLVRIVLEEVARYFSVQKNGELLENAGTIIRNLNSLFKDVHTALRPFPSALGVAIVVAITNISVSSSMQVRRRMKNSSNLLTIRDNLAFYVLRESRRFLRLRKSSLNQLIHMNANNAKSIAVLLFHLSNSIKENNVNEVEVLAILIRQLAGADSARLRELHALLGDSKDVHPLKELLRGNAGAITGQRSTALGTHASQSALSDHCGSDTLVDVDLSAGGAELATWGPNYRACSSLLKEEDGELSLGAHTVQLLEWCKTHKETWAAIQRNVHAAMASMGLEKIDEKAQQQQISSTSGSQKVSTGAFVGLSDRSKRELQQLRDELESELAKLKANDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0P2</accession>
    <name>A0A088S0P2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Iron-sulfur cluster assembly protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_343480</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; iron-sulfur cluster biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NifU family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702773.1">
        <property type="nucleotide sequence ID" value="XM_010704471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0P2"/>
    <dbReference type="GeneID" id="22578853"/>
    <dbReference type="KEGG" id="lpan:LPMP_343480"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340041700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_343480"/>
    <dbReference type="eggNOG" id="KOG3361">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1925777at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1010.10:FF:000005">
        <property type="entry name" value="Iron-sulfur cluster assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY ENZYME NIFU HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82649">
        <property type="entry name" value="SufE/NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIF system FeS cluster assembly NifU N-terminal" evidence="6">
        <location>
            <begin position="25"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO01973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="165" mass="18052" checksum="1AAC6C2B996F84A0" modified="2014-11-26" version="1">MRAFFRVGVTAMPSPAQLCAMRTLYSEKVQDHYKNPRNVGKLDKNDPNVGTGLRGAPECGDMTQMQVKVNPDTLVIEDVKFKAFGCGSAIAASSYASQAIRGKSVADALKLTNKEIAQELSLPPVKLHCSMLAEETIHAAVENYLSKNPTLKSKVLKRKEEAKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0P9</accession>
    <name>A0A088S0P9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Rieske iron-sulfur protein, mitochondrial, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">RISP</name>
        <name evidence="13" type="ORF">LPMP_341390</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rieske iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702566.1">
        <property type="nucleotide sequence ID" value="XM_010704264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0P9"/>
    <dbReference type="GeneID" id="22578644"/>
    <dbReference type="KEGG" id="lpan:LPMP_341390"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340019900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_341390"/>
    <dbReference type="eggNOG" id="KOG1671">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1637982at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03470">
        <property type="entry name" value="Rieske_cytochrome_bc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.102.10.10:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit Rieske, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006317">
        <property type="entry name" value="Ubiquinol_cyt_c_Rdtase_Fe-S-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01416">
        <property type="entry name" value="Rieske_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Rieske" evidence="12">
        <location>
            <begin position="233"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIO01766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="297" mass="33774" checksum="979151E27D02C818" modified="2014-11-26" version="1">MFCRSFISAFQATRAARVSLVFKQLEGNMPLTKKDKPVNSWSDEFMKPPKSTEMTKKYGRYAKYSDPALCDVDTSEEVVLNTYPEGTPQGRIEATAGVALKDYDASMWDEEFFRKHILKPKLADDMEDRARVTDYALNSAMLGFVILMARYAVLPLWYVGQPAMSMVGQMNIEAEVGELDERQCTTVVWRGKPVFVYRRSARQMKELMETPLSVLKDPETDEARFPDRRDKAVVIAICTHLGCVPIPNEGLFNGFFCPCHGSHYDPSGRIRQGPAPLNLEVPPYRWIDDNTIYMGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0S9</accession>
    <name>A0A088S0S9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial carrier protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_343860</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702808.1">
        <property type="nucleotide sequence ID" value="XM_010704506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0S9"/>
    <dbReference type="GeneID" id="22578891"/>
    <dbReference type="KEGG" id="lpan:LPMP_343860"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340045900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_343860"/>
    <dbReference type="eggNOG" id="KOG0760">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="250329at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048250">
        <property type="term" value="P:iron import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758:SF19">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758">
        <property type="entry name" value="MITOFERRIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="17"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="134"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIO02008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="237" mass="25874" checksum="D2663F224414DC89" modified="2014-11-26" version="1">MMNVTLQPLRAAAAATPSSVRFFVCGLAAETVSCLVWVPIDVAKERLQSQPPSLTCRYTSSLDALQRILVNEGVRGLYKGYASTLASFGPFSAVYFVFYEYLVKRLTELYTVTVRAPMQGGRSSRNEAEPFSPATFAVALSAGAGGNVVASLLTNPLELVKTRMQVQRAVLYRRGVGASTSGLFAYRYRSLREGLVAITKEEGIRALWKGVGSRIAYTAPNAALTMSFFEFLKSQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0W1</accession>
    <name>A0A088S0W1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_322550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701940.1">
        <property type="nucleotide sequence ID" value="XM_010703638.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22577996"/>
    <dbReference type="KEGG" id="lpan:LPMP_322550"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320031600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_322550"/>
    <dbReference type="eggNOG" id="ENOG502S64E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267378at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="857"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="996"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1175"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1359"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1459"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1727"/>
            <end position="1800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1826"/>
            <end position="1860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1907"/>
            <end position="2035"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2048"/>
            <end position="2078"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2435"/>
            <end position="2499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="874"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1032"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1359"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1784"/>
            <end position="1800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1833"/>
            <end position="1848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1907"/>
            <end position="1922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1950"/>
            <end position="1965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1975"/>
            <end position="1985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2048"/>
            <end position="2070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="2442"/>
            <end position="2451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2563" mass="271147" checksum="10A4FE0ED1A7BBD9" modified="2014-11-26" version="1">MPYRSYDGPNETPNASLTDAGDGCYAFSPSCRTASSYVSVMDHADEFDCHAPIRDRSTPLRPTLQSMDCMLSTRATTDVSSASAVRPSPTVRCTQRQPANASTHRGCRATQNVRAYGPIDDVVASPSATQGFPRDMALSPRKLDSDNAYRLRDSSISSIDAGFTPVDHHDVTAGKAYGSYPSDDVRVFRPTVNIGGTHTFAVAAVTTLSSPSLPSASLPVRTEGSRRPPSSSTPPTSTFVQTCANDVAALRSHLNALLRQQALVSACGAPVHYNDAVSEADCIGDRSSGPPPSSLLRRSGSDSALLCAVLRPSRPSIHAAHLQVRTSQDLERPSAEAPLPAPGPQVSSFLTPSLVPGATPTLDRASELFLRSIAGHQQLPQPPLMGASEGAAHVAGARHSSRVNQHVRQARAQQAFDTQASELEQQLDERLTLVFTLMRRVMVLDARLAAGLAATPSSIVPSSGADPDRHRELLVRELEESEDATVSTLLRFVRLASRHALEWMNRGQYSAALQLLQQTDRLLSKDVGRVFRYVPDLLELDGHSFSGVAGGCAGSLACHDTAPRQQPAAASAQARSHDMKGPAALTANDIGASANHISSANNVRSMSVPFFSPSQELLRLEAVAAVEHNLGVYHFKLGEYTLASARFARSAALEEELRAPGIGITYFNMAQTQHGLQQLAEALQYAEMAEEAVERQVFVAKDKATKMRRRLTQGRAFQVMGHKDGAYAAGGGGEDDREEDAAAARMSAGGPLYGDAAANTDGKEEKALMRMWLEWRENVCFLSHVKQKHADWLDEMGLYQAAYQHYQQAHNWLLAVPRLAPEEQQRAQSLRQCMTAMKKRWRREELEVELYHHPLRRSSAATSEAGPAVSHPSHTGRTRASSKHRARMHQRPQRSPGVFSAAAPVARGLTSPLQATIVTSVLPRTVEVIGKRPLRPSFACDRASCPTSHEATFRRSSATTFVPQPLACVQTRSRPSSASAAFYSAYGLRRPSVSSLPHRHGIGGHATAAPKPDCPHLTHPPLAQREPPPLQRRGERPLRDPSMRVPIPPPGRRTRHHTSAERDGSAAPGRLPRRSSAPLSKDKAGEPGVLTTAHLPPQSSSTYYDAGTRFASQHHHSPPHELEPTSSTSVESCVVRSLLFEAKPETPKMLPHHCRSEPFVLDELSVKNMTEAAAVSSAPWSESAATPKGESAGAGVSDLVTSTSSAAVTPPGLTPCFTRIPDDLTWCATVLQAFLRPLCRHRTLLGMEVGRDHDEHTARCRDALHLAQASCQTETSTVKHASQRRAADVVKAAMLDGDDTPSDAQPRSLSPKSVASLMAPQGESRVSQLFGVGLSGTLVTGAVGSVSCSTSAVHLSSSAAASSSSADVAHTPGVERDASRTQAAAAGEEGAIADARLDGEGACIQLSAVEHGLSTGTVRGGVSERENEGIRSLGDECGREVAVAAIVEWSKSLIPCERADEGTKGSSVAEEPSDTKSSGSFHDETFHDLGDSVAADASAATGNCVMMRKHDAATAAASAPSSMNRGKVEREMNYLHDPSVADDAVALKVELLGWGQCSRTPASADALIGSGGASCYGAGCARTSTANVHDIEEAEHEEVAMPTEERENAPSSALVLEAASSVPKEAELVSFNPLPQLDASDEQGNVVTFMEAHAHEEGQHLACAAEQSGPSAQRIASPSRTSLDEVLRTERPAPTHDEAAVADALSAHQSTGLRKVLSLAATREGSAGLPASAAEDNGDVPKPPSPSPASSAARIGRRTPSLSPPGPEGRGEGGLEAVPPSPALSPSSHSEESQVQQEVSQCVDEAYGADSAGLGAACETKACDSSEAAHMTLSDRSREDDVGDRTGVREGILSDSPPPLAAFSASAEDICCNKREDTVLRGGSLTRASVSAAAIRFTADLHEARQPISSSASVCTVNQETEGGNGPVSDGLQGETEKEEGDALPNGSEEAVRDEETSSTEREKGTTVALAASVASPTAEAQEQLASPAANGSHPPQHGRAATLFSLLPSSENAGPSRGAFSETPSRAASAPHDEGAGLQMAVDHANTKATEEKRSAEAAKAVEERRPAAEVEVAPQPLAASPRRRGRVFIFVAHKMATPVSMELRNVYSSVRSDDAGGRIRLPTRTLLQPAAILNAEVVEDEAAKSLLALAGSSRTTGSPDAPLSFKEEYCCAVEAETYATTEDETLGRHTASIGSTTTQITQLRESFWRSIHDRSEFRPSEGGSTVINAQRLLGKVEVVELAKVRALGSPMGPSTTTMQSQLLLPSALVDVAGASEALVSVGDDFAKAEDKDVQPRQAAQQDLLSTHEIDIVEDVDSPPQHTASAPQTLAPLGSIMSPCLLPVLTPIAASATAASVEAPREPGFAAQLEMTPSTAASLPVSLPPESLATLPEVAEASAGLLSPRNSPLDGERDLLCVGHGGGDIGEAVDQGEGEGLAAAEGEEGIEEDTSPPATEVKNVGVGTGGNAWVRSEGAHDASMTPHRRSAGHPLSTPLSTPFYKLQPQRQRLGTNKSTWGDAETDEAQRRYIRDQIVQEEAATVIQQAWRGCAATRRRRQLYLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0W5</accession>
    <name>A0A088S0W5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fumarylacetoacetase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_342300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702656.1">
        <property type="nucleotide sequence ID" value="XM_010704354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0W5"/>
    <dbReference type="GeneID" id="22578735"/>
    <dbReference type="KEGG" id="lpan:LPMP_342300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340029000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_342300"/>
    <dbReference type="eggNOG" id="KOG1535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000027">
        <property type="entry name" value="Fumarylacetoacetate_(FAA)_hydrolase_family_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="30"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="121"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO01856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="274" mass="29794" checksum="554F7E43BDF1AF95" modified="2014-11-26" version="1">MSSLAFTLRQTVVPVVTKLAKPLYFPVRRIYCAGPNYDSHAREMGGVINRTDPFFFVKPTDCLVTDFGNHTSPSATIDIRYPPVTESYHHEVELVVALGYPTGKAAAFSAASQDPGDTHYSNMKIEEAADIIYAYGVGLDMTRRDLQLMAKNNGRPWDLAKGADGSAVVSPLVLSRDLKEAHPEMFMSPDKDETGVVSSGSIFLQVNQNERQRSDLNCMACPIVELLAHLSKYVALKPGDLLFTGTPSGVSAVRRGDVIEAGIQGLGTLKVNVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0X5</accession>
    <name>A0A088S0X5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GPI transamidase component Tta1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TTA1</name>
        <name evidence="2" type="ORF">LPMP_322700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701955.1">
        <property type="nucleotide sequence ID" value="XM_010703653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0X5"/>
    <dbReference type="GeneID" id="22578011"/>
    <dbReference type="KEGG" id="lpan:LPMP_322700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320033200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_322700"/>
    <dbReference type="eggNOG" id="ENOG502S5H3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="247334at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="440" mass="47577" checksum="83AA1C135017B119" modified="2014-11-26" version="1">MTNSPDRTKSTAAAASSETWRRNSTNSFAALNAFIFLVVMSVHWTTMSREHVELPMDRVVAELQASCSDPADTPSLTPSMLPPAFYGLAVWVDSPALLPGVHVALALMKERLAGSLGSAAAAVPLPTHTLYSSVRLQSRMRDDVVTALVQEAQSGRLPGAERVARELEHLASQQQLGLPMLKHAFLPEVGQEVELFGLSLFSVPVSVLPGDAASKVQCFISGVRQAYCVLPVEVPDASDVDRGGAGAAAFSKTHVLAASLTPSSYRLRAASLEAEVRAALLSVTTQQIDLASFNPADVAAWKRAREHQGCLYTIASVTSTLRSIAANPNMAVPRSTERMFADLERLVQSRSFLRAARAADDLQFHPSLTPQLYIPWDHAVVFQLIVLLPIVSCALLTARFLVEERRQNRARAKAAAEANEANKIPGEVRDSFTALQKKMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S118</accession>
    <name>A0A088S118_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytoplasmic dynein 2 light intermediate chain 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LPMP_323410</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein light intermediate chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702025.1">
        <property type="nucleotide sequence ID" value="XM_010703723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S118"/>
    <dbReference type="GeneID" id="22578082"/>
    <dbReference type="KEGG" id="lpan:LPMP_323410"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320040600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_323410"/>
    <dbReference type="eggNOG" id="KOG3929">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10263060at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035735">
        <property type="term" value="P:intraciliary transport involved in cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040045">
        <property type="entry name" value="DYNC2LI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13236:SF0">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 2 LIGHT INTERMEDIATE CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13236">
        <property type="entry name" value="DYNEIN 2 LIGHT INTERMEDIATE CHAIN, ISOFORM 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIO01225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="428" mass="47122" checksum="CF4C44C3DBFC326F" modified="2014-11-26" version="1">MTGLPVDSKSGASSNGGQKSVAENRQPPSNSSNPPSEEGAESLPRHPPELSEAPVTAAADNNSQIVIDPTKDLWQNITRNVKDAAVEQTEINLVVVGAPGSGKTTLLHRIYTSFQSSASGSCSKRVKATTALDYSFARRSERNVAPVAHFWEIAQGMQFSQLLDIVVTPENVHAIVAAVVVDASAEGLPVAWETATYWMRRIDQRVSDISQRMKAKGSTTPEKLLTRAQKAVGLEHPDLKRMRLSGVPTVLVVNKIDAFRGDMQQLKLLCRSMRYLAHLYGAHVVFTSEQESVRWRALMNFTLFQAPFDPKHLQTDPERGAVLLTADRDSFLDIGDPNMSRLGGGGSSASTGDAELDRWKVPFDDAFPPKKLNEEDKVMDDPFIRRLYDTSEGGFGEPMIDTLRKQKDEELEQYRKNSSNAANVSKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S176</accession>
    <name>A0A088S176_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RNA splicing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_343970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702819.1">
        <property type="nucleotide sequence ID" value="XM_010704517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S176"/>
    <dbReference type="GeneID" id="22578902"/>
    <dbReference type="KEGG" id="lpan:LPMP_343970"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340047000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_343970"/>
    <dbReference type="eggNOG" id="ENOG502S5ET">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="274726at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009846">
        <property type="entry name" value="SF3b5/RDS3-10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978:SF0">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07189">
        <property type="entry name" value="SF3b10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO02019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="84" mass="9859" checksum="C7E8F7547CDD99AB" modified="2014-11-26" version="1">MGDPFVRPGLEYAPHVEQVLLKHEGTMTLETTKDDWMRYQHRDTLAAIIEHRDQIEHLCIAENLPPAKMERILLERMVDPIAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1G4</accession>
    <name>A0A088S1G4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BART domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_344340</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702856.1">
        <property type="nucleotide sequence ID" value="XM_010704554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1G4"/>
    <dbReference type="GeneID" id="22578939"/>
    <dbReference type="KEGG" id="lpan:LPMP_344340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340050900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_344340"/>
    <dbReference type="eggNOG" id="ENOG502SH04">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="240947at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1520.10">
        <property type="entry name" value="ADP-ribosylation factor-like 2-binding protein, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023379">
        <property type="entry name" value="BART_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042541">
        <property type="entry name" value="BART_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11527">
        <property type="entry name" value="ARL2_Bind_BART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BART" evidence="7">
        <location>
            <begin position="12"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO02056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="169" mass="19025" checksum="4C69F0293B3C35DC" modified="2014-11-26" version="1">MQPTWLPDTKASALLDELEAFFSQGSSTDRLRQFIGENEGTFALIASESAVNTDTEVSLRLYHLFQKYGSLIEALIGEFMATMEKPDESMLQSLTSAIQEEWKSPNAAYRCVCTSYVVASMDYKEFLEFVDDMYSMTHYRMLMDEDDDSGKDDSEGIADGASNSGWRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1R7</accession>
    <name>A0A088S1R7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_041140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="AIN95436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703758.1">
        <property type="nucleotide sequence ID" value="XM_010705456.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22572073"/>
    <dbReference type="KEGG" id="lpan:LPMP_041140"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040018700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_041140"/>
    <dbReference type="eggNOG" id="ENOG502RS7M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273460at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1249"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1314"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1888"/>
            <end position="1915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1263"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1331"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1894"/>
            <end position="1907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2364" mass="254955" checksum="33ACD8A147981537" modified="2014-11-26" version="1">MSEIRLSSYSAVCWRPGKAGFVDVVGPISRTEVPQQTSSGSGTVVSAPIALECVRQPEQDLIVWLGWKGCRDFKKGGKGLHKVLYVCTTVTHSGVFFTYHKGERLGFALITHDSNDPQKLGSRPTLYKEELSGLMADVLHDGEGKKTSKQLKQRQLVTVRQAVIRETLEGHVLAAVFINRRGDVYALVAHLTKNAWRKWRMDAAIGFMPCIHVSDGGRDVRLVHCDIGEPIDHTSTTVAPSLPLALLTFDRVSMSSVIWAAQVAAAAPPLLCVRFREFILPTRGSEVAAERVFQSQCVECVLDNARKVQQPCLAQVDEATAVYTVVVSWEQSSYLLHMRHSLCGSGLMTNCTMVAGLHRPISACTLSIPSLHRPRGARVSLVLCDDMRVYCCEHFGHVASVSLNIEGVDCSVLTLPAPPAGKSTRKVWTATILPARLIPLHNQTEVLCTNGTVGLFLRVSYASFSETVPVPPGVAVEGTIETAGYGTATEVGVGAAALRLCLESLQRLSVRTARHDLPDVVFRHIMPHLRYVGTSQQEVMLMQRLYEQLLQMAKPILESEWTYLWSLTSLLQKALVKRGRDNQLRYTDTFFLQLADAYRQSSFASPSGETLVGDGVRSVVSVEAQGVIAAPTATLPAEVGYVLDGLAAGVAPVALAEEIVRRMVRTETLLNDICVVSSQDGVASCVHCMGCVLVASCLDLSVFAIADEAGGLRVSLQRPQDGVCVAVQPYTFANQEEFETALSLAGDLLCVYSADESFRPDVALLTLSIGRRQHCLTTFLQLFAPVLRQAVDAVMPLSSNRDWFEKCVATLAQPSTEWAVSLLRKGSSDSFTITAALCHVLCTAHNGVDAVFFRSLSGTLSVEFCATALVARIFHQTERLLAATQNYASALTTYISTHKSEAEQDTHAQAMDVGRKRLHTVLAQTSALWAQMDSLSPYPVRDVAESYRISVGISLAPVASTASALTEGTMVSRTLVLCFRIFCLVQYSLEVEKDASLAVSAESASWTADDAIVRDCQGALEALYLLVDSPFPLEWLQWKFMSHVRYAATIRPTWVPFLVRLMQLSNVRQSSSANLKRDFYTLLGALQIHDVSSTTKVAEGDIQRAIAAAESTVGAVAIQAGHCGPAAGTEGDRPAQSTPTVFFIFSHQRDPSLPSWTDSHSLPERRHLFATNWADALWTLERVPGALQKACAAALARVQLAASEESTTSRDRPHLPALSEELALSLYAHLYRLSPPVRIHAIADAAPADGDGARGDVQQSEARVQEYEEASREPTATPEKLAASPQQEQAPVTVLPSANMTTPGPLLSLSVEPEAAVRTGTSEPTPKEQPSSKASASADASADAELAASTRTGLYSPASVAWWDTLETTPNPQRSFGVKAECATATATSPVTADDNGESSDTATTYTTSTSYYADPVAMLRSYHPRCYTRGDRHMAVDSVGSSCSSLESHCCRRRYAAASSPAQYGARKKCRCCSRPLRVDSRGRSVGRRGEVADEATPIRVQWRETAEETTPTHVQRPPVAAKSPVAAAARPADLAFSTALQPPKEPSRVASPMPLLTFSLAPNRKEASRVRLYVLDGDRARLADEQETVLLSTASRPVAAPTTGTLLEVPPLPATSVFVAPQPLLRLPPQPAAAQLERRAIRASDAAEAAQPVRFVQMERPYPQAPRAPAGVAPPAVDIATLQTPATNAPVPVRPADEIASASACAAAPVAAPYVPPAPAILTPRPVPTVSPVGDPSVLSPAQMCEFRRYIDDLLARQRGTAPLHVATTASALTAAPPTPESATAAPAATNFFRTAEIERLLEQQDSFIRKSEAILEALHAENDGFHQRVMENIRSLTTVSQQLRGLSPVEQAQLVQDTVKQRNELLTLNHQLLELQLAAARVSGEVPPVPTTASGSSQAAPQRVTSTSATQTQAQLRESVGVSWATTDGFTASTTAAAATVPSPIKWAPGREGMRETLSDLHRLNAELMAVGTSAEAMEKAIKETREVIQRYERYKMAEALTAEGVALTSAMRQRTAAIERRLAELPKTVERTAAPGEKRSSSVWIPQRSVAETVGDPLAGVQPAAWRPAFISSAGGAPSPSSHLPAQAETSAVVTGDALLSRNVVQYLPLCNPLGAMSPSTSVPQMAKGPQPEQQASPTVAVCTAPVASIAKPPDFAVFTSVSSTPIDEVMMPRSATQEAPQPNVSLHAEWTTGGEVPSLHVRETMKPTNLDLPRAVSHDITAPRVTAQLCDPSSSLVEDGCRYEALCNSSTAPLHRRVEALPLRSLLGCSQALKPHTVERRCSPNSHLWTRPHHMCEERYAMYRATSRSAKVRPAAAARSNMPGHRCVLTGDAFVDRQQRRRLASIAKRMEQLEEDLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S238</accession>
    <name>A0A088S238_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">40S ribosomal protein S9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_351280</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703066.1">
        <property type="nucleotide sequence ID" value="XM_010704764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S238"/>
    <dbReference type="GeneID" id="22579157"/>
    <dbReference type="KEGG" id="lpan:LPMP_351280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350018400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_351280"/>
    <dbReference type="eggNOG" id="KOG3301">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="259794at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000023">
        <property type="entry name" value="40S ribosomal protein S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_uS4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005710">
        <property type="entry name" value="Ribosomal_uS4_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003139">
        <property type="entry name" value="PRK04051.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01018">
        <property type="entry name" value="uS4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF5">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9 12" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 8" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="11">
        <location>
            <begin position="5"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="10">
        <location>
            <begin position="106"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIO02266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="189" mass="22065" checksum="4E1EF89CF4363573" modified="2014-11-26" version="1">MRNYNNFNRVWKAPRRPFEKERLDREMKLCGQYGLRCKREIWRVNMTLSKMRRTARLLLTLPENHPRRLLEGSAIMRRCHEYGFLDEEKDKLDYVLSLTVPDILERRLQTIVFKAGLAKSVHHARVLIQQRHIAVAKQIVTIPSFIVRVSSERHIAFADASPFGNGRPGRVKRVRVKAAKRHAAGGDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2G1</accession>
    <name>A0A088S2G1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_352740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703211.1">
        <property type="nucleotide sequence ID" value="XM_010704909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2G1"/>
    <dbReference type="GeneID" id="22579303"/>
    <dbReference type="KEGG" id="lpan:LPMP_352740"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350035200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_352740"/>
    <dbReference type="eggNOG" id="ENOG502QU57">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="244954at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO02411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1005" mass="112269" checksum="8A3484986E0316F7" modified="2014-11-26" version="1">MSLADAITLLRGLYGSTNNDHRKDCTLQLMQWEKGLPAADVAQIGIGLLKTSNEGVAVQAYGAVLLRHALHARVLQTTQLPVMDLFSWYCNEPTLGPLLRADLMELLIECVIYSEDAVVDQILGSLCAGIESQPRRMLLLSELIVALVEPDFDRVPRESIGRLKRSVTKQGSQLLSAVTMSLYTYYMASGGEQSTALAPDLGLCVEAAFNMIGILAPQLQFCVWQEHNLAATMEVLLRWVPAQHPVLTCATALLRSYSGSDVNKAAVLRVLLTIVLRKIPALVAEGDIAALDEILNLTLELPKDFVQLEGVLLVQSLMPVFSIPSILFGQEAVQLMERMGEEAFRYVDAVEIYNGLRLLLPKNLCHPTQGKSPEGQELSREQFGFVQLFEEVFADFRRGASKILTQLARMYPERTNQYVLSLLVDLPDPQGTPEDPRTRNHFVRQSSLTFVYWEATQFMMECLSAAFELSSVNVNACVSTLLAHEPSDAVLRPVYLNMLSYFWKVRDGADMNVWEGTINILLKCIGDEGSRCTDDIDVSAARRRAHTLLVQMCVEHSRRFVPRTPSLMKQLEPMLMRANGMERSLLYEALIALTAILPAHESDAYLQTIVNPLVNMLATSPALQSQKIFNHIMCAATPDDKDARGVLQGCLNTIAAVFRRCQMTPYVVEKATQLFPLIGHLLLSIHSMQPSDLPPEYRSILEQEAGERDLFLPGKTRMSDAHLANALRGARAILMNIRVALYQVFGELSPILPAERFGEVITALTTSAQIPTHVTRSLTEKCLLPIGKEHPTLLIYIFQLLHRFFAQRKEQVRQQRVEEARVRNTCDDVVESKQWLYYAKDVINFMRSHVLDSHSWKRDKALLLAAAEVAMSIFESGADNRTAQSFLISIVNLTTDTTVSPEVEAALTEVRVVVYSRLVSYVTQTLDGELPPRERENVAYGISEPYVRLFPSLAPSLTMAGISQEQQELLNAHLLIVGNFAGQRRKVKEFLMNMAKANVEASRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2U5</accession>
    <name>A0A088S2U5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="2">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_355520</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="2"/>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703483.1">
        <property type="nucleotide sequence ID" value="XM_010705181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2U5"/>
    <dbReference type="GeneID" id="22579580"/>
    <dbReference type="KEGG" id="lpan:LPMP_355520"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350063900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_355520"/>
    <dbReference type="eggNOG" id="KOG1448">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000002">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002320">
        <property type="entry name" value="PRK01259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF113">
        <property type="entry name" value="SYNTHETASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="12">
        <location>
            <begin position="12"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="327"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="327"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIO02683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="358" mass="39144" checksum="6B3FD3A7EECFA875" modified="2014-11-26" version="1">MEPCSSRNGSLRVVHGNANPKLAEDVCRYLSIPVTASRVGSFANGETIVKILESIRGDDLFVIQPTCGNSTGTNVNQAVMELLLIIHTLKLSSARRVIAVIPHYGYARQDRKHTGRVPISASAVARMVTEMGVNGVVTMDLHCGQIQGFFHGCPVADLSPSSEFAEYVKQKNFTPNSLVVVAPDAGAVSRARRMGDRIGASRIVTILKRRVVANQVESMQLVGEVEGCVCIIVDDMIDTAGTLCKAAEVLKEYGAKEVHAYATHGIFTDPACERLTQCDALVEVVVTDSIPQEESRQKCKKIKVISIAKLLADAIYRMHSEESLETVGHPEHFMPKHGDDLQPLESLVEEDEWSRHNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S573</accession>
    <name>A0A088S573_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Stearic acid desaturase, putative</fullName>
            <ecNumber evidence="15">1.14.19.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LPMP_140500</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.1" evidence="15"/>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697284.1">
        <property type="nucleotide sequence ID" value="XM_010698982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S573"/>
    <dbReference type="GeneID" id="22573317"/>
    <dbReference type="KEGG" id="lpan:LPMP_140500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140010200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_140500"/>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1600">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10260134at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009160">
        <property type="entry name" value="Acyl-CoA_deSatase_haem/ster-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001522">
        <property type="entry name" value="FADS-1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000345">
        <property type="entry name" value="OLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00476">
        <property type="entry name" value="FATTY_ACID_DESATUR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="14">
        <location>
            <begin position="341"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AIN96631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="460" mass="51753" checksum="5B7291D5B15F6FE7" modified="2014-11-26" version="1">MLAAVQSLFTCSVLPADVAKPKEEREVPQWTKGNFQYNWIGIYIIGVPTLFVLLGLYLHIPLSPSLLQWLIFFGVVTGMVGVTSGYHRLFSHGAFTGGQAMQWTCAFVGAGAFQGSIKWWARNHRVHHKYTDTCKDPYNAHRGFFFTHFGWFVMRMDYELLGDADVSDLKDNLVVEFQRKYFAVIATITGILIPLVVAGATTGEWLGAFFWVVWLKIFLVHQFSFLINSLAHTRFFGATRPYSDDLTPHDSTLLAIINLGEGYHNFHHQFPNDYRNGHLWHHIDVTKWYIFLCSFLGFCDNLQRAPRAVIDRAAAMQAVRTHERGLVEAANEVRRLEVPATVEYTWDDVRAEVRQGRKLIVMDGYVLDIEQPIPVDPAWAQTDKINWMNTHPGGRALLLAYVGKDATAAFNGGVYGHTMGARNYLPELRVGCIKEPPVPAASGKKVSGAGRLGVVKYTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S5T2</accession>
    <name>A0A088S5T2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial ornithine carrier protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_160210</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN96896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697549.1">
        <property type="nucleotide sequence ID" value="XM_010699247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S5T2"/>
    <dbReference type="GeneID" id="22573598"/>
    <dbReference type="KEGG" id="lpan:LPMP_160210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000024000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_160210"/>
    <dbReference type="eggNOG" id="KOG0762">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="409586at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000099">
        <property type="entry name" value="Mitochondrial carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF12">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="4"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="93"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="192"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN96896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="299" mass="32633" checksum="0593E81B896F5AA5" modified="2014-11-26" version="1">MSLRNDFISGTAGGFAGVLIEHPFDTVKVLLQSYGGTRYVGYTDCITKLIRQDGAIGFYRGVTARLIASSLEHAWVFASYKWTLRLIGAGDRPTLPQILLGGCGSGAVATVCLTPFELVKCRMQADGRKGQRQYRGSLDCAQQVFRQHGVKGFYKGGFAMLCREVPGVVVWCGTYDTLKSWMTPEGMPSESLPLWKLMIAGGCSGVAFWTALYPSDMVKTRIQVDPMYGRLSLWGAMTRIYQSEGLRALYRGWALTAVRSFPSNAVIFAVFDGCNRVLSPEPLLMVGASSTLSEPSAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S675</accession>
    <name>A0A088S675_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">NADH-ubiquinone oxidoreductase, mitochondrial, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_170230</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="9">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697714.1">
        <property type="nucleotide sequence ID" value="XM_010699412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S675"/>
    <dbReference type="GeneID" id="22573766"/>
    <dbReference type="KEGG" id="lpan:LPMP_170230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170007600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_170230"/>
    <dbReference type="eggNOG" id="KOG3196">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10254187at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902494">
        <property type="term" value="C:catalytic complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098796">
        <property type="term" value="C:membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000022">
        <property type="entry name" value="NADH dehydrogenase flavoprotein 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1590:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01958">
        <property type="entry name" value="nuoE_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10371:SF3">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10371">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE FLAVOPROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01257">
        <property type="entry name" value="2Fe-2S_thioredx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000216">
        <property type="entry name" value="NADH_DH_24kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="224"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="258"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000216-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN97061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="276" mass="30775" checksum="0C768D35CC72316B" modified="2014-11-26" version="1">MAMRRATAASGSAAAVAPTADNSLTSAALLTNTCAIHGEVRHHNTDYDNTRIPWDFTTASYEKIYHEILPKFPRGRRMSATIPLLHLAQQQQGGYIPVTAMYKIAKICEVPPMHVFETVTFYSMFNRHPVGKYHIQFCRTTPCMLCGADELIERTMHYLNVRMHGTTSDGLITVGEMECLGACVNAPMLVVSDYSNPPNFSYDYVEDLTWDSIKTLVEDLRGGKPFKIGPQRPDRRCAEPAGGRTSLLFKEPPGPYCRDFDAKPEEKKADAAPPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S8N8</accession>
    <name>A0A088S8N8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_204940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698693.1">
        <property type="nucleotide sequence ID" value="XM_010700391.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22574706"/>
    <dbReference type="KEGG" id="lpan:LPMP_204940"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200067100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_204940"/>
    <dbReference type="eggNOG" id="ENOG502RYKW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266014at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="669"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1093"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1159"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1278"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1361"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1480"/>
            <end position="1510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1110"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1165"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1284"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1480"/>
            <end position="1508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1643" mass="174188" checksum="4AD7AB052ACB6275" modified="2014-11-26" version="1">MGAVPSRECTSLFSYFRGSYEVGMVPLTKYYFGKDTDTSPDPVDIDGSAQIAPLQRATTASRKPQPQLPSLPLHVGSRSHIRQQLRQQLLLMRRDPAVLYANARDAENILQGLSRQGKSSNHDKSNSGSKAHTTSEETTNGSPVTPVAKATSSSAATVVQTDVDHNAHKNNCAATQEESSRTGASSSERSDSSLRLPEQDGIGAVHSCAEQLLFSEYWSIMPDSNFTEADLDRFLDLVDATLFDTNNELLSADPVLPGTAAATDASSTKPFIPVPCALCLAYPEGKEREGALALEGRVINIIGYFGLMTREMQDAFKVVKRLPSEAEKQQQEQQAQEGSSTSEPLLFLNTAILTSAGNRTLERVLVLAAVMLRQQFHTIGRRHVLQTKLDQLLYEQREQKLRVDPHMVHYLQTLLTLPPRAENQPFFDPLLEIPLPSIPSGIYTPTHYVNAAYNEASQHLHASSLSSCGRTALASFPGEGKFQNAAMGPCADVSSGSSPNMRSLPHDQSASMGGALSAPGASREHMLLYPQQNVSGVLGIALNVPGPGSEGACALLMDGCGGSLGTNNAPTPTPPALGPLPLSQSDEDVITLALCRRIGRRRVVIETASNNYSALKSLTENFAFLCCQILLDQSLTTMELIELPALVETPFFKPSESATTVTTTISSTVADETRTSTAVPQPAADGETKPLNMERLSQPRFPPSSAVLIKLDPLHVCQATMWASSFFHCPTLLPSGGWVKYKLKDECEQLRHVLQNKDMLIAHWRKTDVDQAAHYLGKHTPRLLEHVRALQAETEEARALSAEHWMQQPLYVNQDGRKYGLYQSRYGTMLIGVRAFKAGNGPSTMAAVSTKEKRSGSTKATAESNMPTFLGDNTSLAAHAGWANTDSASLHNLDSGNGNGFAIAPHGAVPRSGGVNGCHTSRHSALSPSNDESMNLLNVSSNGHLKDRYSRGVGGSVGSGCCGGAGYSSNGPYTNYLPHAASGGNGNGAYAPVPFLQPQVYMSKNTGGHNVPPYMMVGTGGRPGEVVSYSASPPMSGYPMEMVSGYNMPPSQQHQRVNMINTIPNLSASRPDHNSSHSCLGSSPAHGMIGWPALQPSNAQIPPPPAPSHMSGTSQGPQQQQEVIGSLSGFAYASASSPMAYNPVPPTCQAASHNTNPAVAGTFAPASSTHSPRISSEQVKSSPLRADVATTSQSLLQSVSNNGAQLGLTTDAAKNAAVIGSLVDAKTPWVNKNSEAAKSVPSSTPQGMSTSALPAAAAPFSHGCVGMNRNRVGAAGDRLAASPRNGSAMQQAARSGSDPHATKAADESETADEATTPKTAMLRSVIPWSLQGAAEWVSSDDATDNATQFLLRSTELLDTDDDDAKKASVGGNSDYALSRGTTGKEELGASHVTQLIAYRDMFVADPANQLLQSAPSKNADMSIVNMLLAAPQQSDAAMTSVVSTGQLALPTTTELPKPAPMLPAQPGGVFPMYVLQLPTHTPQQQQQQPQSQPQLPTTSPPQAAALSPDNPLYYTMANGVPLLLQPAAVSGGIAIAYPNGQPFPHGGDGVIPYPTLCQPSPPQQPMQQQQSIPMIPHSQAMMNTPGLGGIPVAQFSAQAGTSWGNQYHFLSNSPGSLPGSFASGFTPVYNSSNLFQPDNTFSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S9L6</accession>
    <name>A0A088S9L6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleoporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_220370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699038.1">
        <property type="nucleotide sequence ID" value="XM_010700736.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22575083"/>
    <dbReference type="KEGG" id="lpan:LPMP_220370"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220008700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_220370"/>
    <dbReference type="eggNOG" id="ENOG502R6IM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271011at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="636"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="647"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1353" mass="146093" checksum="3FEA5A773256EF0D" modified="2014-11-26" version="1">MPCPPSLRSSPLPLPHLSPTHPPLCAPFHTCTLGCVTDFTVVFFLLLLYLLCISAAPLPVFFCDPEMFFAPPAKVARTQRLTVTSSAAAPYVYKRVTEADSGLTEASPTSLDGAVVFDAANGRTIPVSSFLSGAGAHLCWMVDENTKLLRLWNVSRPGWRTAAPRLAEIPYFAAATEGLPMFVSEMGGEEESLAFCSERGAIASLDHSIEVQMIDEDDAALMASSFVCARRWVNAEAVIVTVLGTTAGVLVVDLKYDGTHTTMRFDRRDPASFRWVRGGRDNLLQHKNSGDAEGCPAMPPPYTAEEEGQQQLLNEDAQTGRPSASANVSSWLWHSLKSLVASGNGTSSDRQGGWTGPGGAASVSSVWPLSAVDRGQRGDSPLAFTHVQLRYHYPDQVVAISALGEVFLLDFSPVPPLVAGTAPRPRISIKWATSLPSSLGRSGRVVACTESQHKVCVLYYVRSSSAHPLPALWLVTLDASLGKVVNYVVLNAVADVVSSAARLPSHHVKLFSGDTHCVVLISIGAYVLRVNNQVGVRQPCSSEDTICFAHLEQAVVSLLREDGSLVTLDARGPHLTVRDALAARMVPVASSDGPRRLHDGDDSGESELKSILDAVRTDPTLSLDSAVLYASESLSSSSDSHYPRWQGSGNRGNSSGVGTGNWARRNLNTEDKNIVQRVTRQLTCQQQAHRCFLMAVLRHEEVRKQLSQATIAQMMSVQEALVSLCALRSMQNVGLQAQQSLSSDPDSVTHRVLPPLSDMLGVAPSGGCDGAYLLPRRPYRHDATQDGSNDASGAQAASRLVKSTEQIERCQQIMRRAIVAVADAIRAEQKAALGGASTGLEGSVQGLTAAEVCFADPSNLARLLCFVGVYLSEVRQTVSLPLEEKFAECYAAGCIYVVVAQSIMESREETRSVYEIPKGVLSCMWTGSSDPVRGIALCFSQACVHLSNTLADVCDVASSNINAGTDSNANAVDAAARLASAATLSSLALQRCDMLDVVTYLLYFFLTNNPHHDSRFVSSVVTNTLLREPFLNGPVGYPYGAPAASRGCVEVGLRVLRVCETLALRFDAMPILMTFALSTPIDDPASCPEQYERLQSYCQQNSLVLDAALQTLWEQRREWELLSLPAVLPGCPDARARRNSFLEAQAPHLLWLADPGRYDALTAEGQASPPYIPYGEDQLKHRSRCNAMARLAWVATGAAPSSRINDVELSESIVAGQQEFLGPDYNAVTLGAQAAVQRLLEKRDCVAAWVQAAVIASHTMQPTSEDLLVQVLRRCRAHDGESCLRSILANSVSELETDANLRQTALGQVIVACVKLQDTETLYRVCETLLTAEELTLLSSWVAYLWTASHERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S9S2</accession>
    <name>A0A088S9S2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_220930</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699093.1">
        <property type="nucleotide sequence ID" value="XM_010700791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S9S2"/>
    <dbReference type="GeneID" id="22575139"/>
    <dbReference type="KEGG" id="lpan:LPMP_220930"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220012700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_220930"/>
    <dbReference type="eggNOG" id="KOG0379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="432528at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="553"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="586"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="36"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="743"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="781"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="743"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="798"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN98386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1189" mass="124714" checksum="09774261F2065738" modified="2014-11-26" version="1">MDNEVDARDIAALLAELQDVTGTSVLEDQQPSANAVFSGHRRGSAGEERASSNTTTHHRVSATGCPGHRPSSTAAASGSSASIGFSTYNSADTGLTDAQLNSHRLSATPLGVRLTPLGGGNAVVGLASSPPALLEPQPALPPLPSLGPHGSGVGHSSGTEVGGNLVEVAPSPALTGVFPWPTSSDASAGGKESPSSKATPIAAAAAATASPSIPEAPRDVNFLPIMCARYLRPVGVAPTARLGHTLTPVTPDTMLLFGGLDLHGEETSSLMAFNTTTISWEPLYTLSTAPVARHSHAACAYEGRYLIISSGVAQNGGTILSDVHLYDLHTHHWRCVWNGQRDGSTENHNEPGPRFGHTMVLQEDRLYVYGGKTTSESRQHTQRGSDASSAVATTTAVTTLASGSDVYVFSLSSYRWRRRVRAAKGGRTSSAVQAAAAAAAATQNTEKPGEDTNAGSQLAVCTHPAPRAYHAACIKEGIMYINGGAGRSEVLTDTWALELTTGEWHCLHRGGTTDATPREKHALFVCGEALLLVGGCCSGASRHERITGKLTHFTVVLPLVGMAVSAPCWLPVVMGNTSIVQPHKKSFAAALTGGFVYIFGGVCGAEPATNAMVRFLAADGYVSANDQAMEAGNVGDGGAQQLRLKLQQLREQQRGTPFDCYAYAGTYGSADVTSAVAQLQALWAARAAGENGGLQKQQQYQMKAGEEDAPIAGLHRVIMYQRAPLLLQQLECCRSEPYSCGSGAASSAPSAQQQQHRIPSGRADDAVRPGDRDEVDALLQRVAKGQRGRSEKAADPSSARQDNSSLAGTSAGGTVGLPVYFTNGTPRVPGLAQPLTADALQCLVDYIYWGGLKAKYRVLLEEKNEDSGDGAEANSGHPTASSSTSSFTVEYRARLVQTLEIVKAVGEAYALAPLAALCAGLLVGDRMQVQLARRRSSEQLRTDMAALLRAPSTAANTTMLVVDPHTQAQSVHVLHACILLTASDLFTALLRPLYRTASGGSASGGMSSNRVGLLAAKLSTAAAASPLALLTSTSKRTVLIGPVPLPLPAVLPILRYLYTQQLEAPAEIAFEVMLGAHQLGLTALQALCEAVVAREEVNYQTCCSLYHLARKYHASLLEEIALLTAVSGFAIVRCTSAYQLLTSEEKQNIETLAAELGSSSWVLPPQPTTEMKSRAAYNARWNASAPSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SA07</accession>
    <name>A0A088SA07_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_230240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699183.1">
        <property type="nucleotide sequence ID" value="XM_010700881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SA07"/>
    <dbReference type="GeneID" id="22575228"/>
    <dbReference type="KEGG" id="lpan:LPMP_230240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230007800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_230240"/>
    <dbReference type="eggNOG" id="ENOG502S9KH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="258590at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="13943" checksum="99A69434C80146E9" modified="2014-11-26" version="1">MSSSLRALAGTPSTLCSCWLQSFTTSPSSFACASRSASRVAFATPARFFGNAPSRIRPVEAPHEHAWRQGERESSASVVIVIMFMVPLWLFVLSAHGQEQKRAAVRAWALEHRAAHRNTEGEDDDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SCC1</accession>
    <name>A0A088SCC1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_262380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700058.1">
        <property type="nucleotide sequence ID" value="XM_010701756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SCC1"/>
    <dbReference type="GeneID" id="22576141"/>
    <dbReference type="KEGG" id="lpan:LPMP_262380"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260028600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_262380"/>
    <dbReference type="eggNOG" id="ENOG502S38M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="261119at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="442" mass="51338" checksum="0D1E6E4759936775" modified="2014-11-26" version="1">MSLSEVQHLQELAQQQPTKENNDTLVSEQTLYVEQQLRIKTEAEERTIAAQRELEELKHEIEELRRQTSSLPPIVPSDERAEYFVKWTSLLKEFGMRKVILSFLLSYSAEDFKLAELSTVSYWLDTWTTFFASAESSVRSLKKIERESTNDNTLPPTRHLYDALDEVCRLQLQARTLVGRERYRRSSSSDEFVQEFMDSQKQLREWCRKQRETLEELTKLDDLIEFSNSFYTNVPVMDSNFLVLMEQSEALMGNALVQDALQEVNREWVMLTLEIYDKLQATATRAHGRSSLEKQCVQWTQFMSPRLHRLLLSVQGALAADNDVPEAKRLATTCERLIKEHEAHDIVCTHLSDFTVREECVRPHSIALKAELQSSLTTTVLTFPHHDTAGWQADYRARVEELQEWIEVKSQKGTYMKLLERLEMTKAAIEEHADVLFPDDGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SD06</accession>
    <name>A0A088SD06_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribosomal protein L11, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_272220</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700308.1">
        <property type="nucleotide sequence ID" value="XM_010702006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SD06"/>
    <dbReference type="GeneID" id="22576400"/>
    <dbReference type="KEGG" id="lpan:LPMP_272220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270030400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_272220"/>
    <dbReference type="eggNOG" id="KOG3257">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1091498at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.250:FF:000010">
        <property type="entry name" value="Putative ribosomal protein L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1550.10:FF:000008">
        <property type="entry name" value="Putative ribosomal protein L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="7">
        <location>
            <begin position="55"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="6">
        <location>
            <begin position="118"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="321"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="321"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN99601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="345" mass="39853" checksum="651A895DEBA77AA3" modified="2014-11-26" version="1">MLRRCAAWCLKARPKTVSIEPGSNRFLDPKVEAKAKDLFAVPEFPNKAVLHNWRFFIKAGKAATGPPVGQEFSKLGLKAMDFAKAFNDRTKPHFKDDIELIVRIQVYFDKSYIFRIEPPPTAWFLLRAIRKKRGETGPVGLRGNYCAYLTLEMCYEIAKMKQMSWGKVEYPPIEVRVRRVVGQARRMGIAIIGVDTAHSSPVKGMTEKQYLEESERYRKVHMAQYETLKAKELESAPLIERLHRPNMAPLTNAQLEEGLKDANLLNALWKSSHPKSLFAQDSRDREMARRYLNTRGWFNEMTPEEMRVVFLNYRLPEQPRQQQLGMTEGQVQSQAYWSRDAASPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SE17</accession>
    <name>A0A088SE17_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_290510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700659.1">
        <property type="nucleotide sequence ID" value="XM_010702357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SE17"/>
    <dbReference type="GeneID" id="22576815"/>
    <dbReference type="KEGG" id="lpan:LPMP_290510"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000044000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_290510"/>
    <dbReference type="eggNOG" id="ENOG502SN7D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="263994at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="222" mass="23470" checksum="497404FFCC5A89B7" modified="2014-11-26" version="1">MQVAAQGQTLSNALSFWADVSYGDMPPTALIDYPPLGFEAVPASRYATAADGGRQLGRRTQPASDEDGSTQPVLLLGAKAESTTPAFDHEGLEEAGLEWCQPQLLLWPGERLKDRRFAAAATTDPLAPVPHLRYEDIGLLAVVYVHSSGIAYVGYPQASGPASNPEPTDSPLQRPENALPDDTLSVAPPPSLPPSQQLPSVPICLLPMSSSTGFVRSLLGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SGS0</accession>
    <name>A0A088SGS0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_321260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701812.1">
        <property type="nucleotide sequence ID" value="XM_010703510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SGS0"/>
    <dbReference type="GeneID" id="22577867"/>
    <dbReference type="KEGG" id="lpan:LPMP_321260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320017900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_321260"/>
    <dbReference type="eggNOG" id="ENOG502SM8D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273855at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="560" mass="60128" checksum="6E945160226FA364" modified="2014-11-26" version="1">MHSSALRAGSMSAVLRQEHLQQAIKEKQLCERRHHACALMLRKHDLVGVLAPRGLPELRIQGSPAQVRKPHPTVSPMPLPSDLGSPESIIFAITYERRRLSSQSVPVNSDNGIAALVAPSTPSQSRLSPSKEFATRLSRLHKAAALGLAAIQGQWCDSLHVSPIEAQSSADKADASFPSYLNGSSALFGDRGEVSGLGCCEVEGARHVRFSSRSPQVATFSVERPCVPRPEGWTATESAPAAMPETPPSEVAKLIPGPELDLVQRSPSTHRNSNSPWVSTLVMSPCVASPHSTIPSPQTSVISYLSRIEELRSSLLEAPWNPCQSNRRLSDDARLPAQPVQMLTMAENPSGMNEKRATNGQDVRESAPAPLRQSTLDQTRCLGESAGAAAVGITSPTAFGAVGLIGPLPRGASLTPAMSETFECFTESSPIFLRRPERRPEAPTQDTRLSPLFSNVTNQLTESSTPPPPRPRMPGKKDTLVTHKATKKCVRFHESVERSDKGGTSTACKRRRSERRAAQPPTSAPAVVGVPIIMAAELCCEQEGFGAGILLACGPTLYFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SIC7</accession>
    <name>A0A088SIC7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Eukaryotic translation initiation factor 5B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Translation initiation factor IF-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_332860</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702377.1">
        <property type="nucleotide sequence ID" value="XM_010704075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SIC7"/>
    <dbReference type="GeneID" id="22578439"/>
    <dbReference type="KEGG" id="lpan:LPMP_332860"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330036600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_332860"/>
    <dbReference type="eggNOG" id="KOG1144">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4928at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03703">
        <property type="entry name" value="aeIF5B_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000013">
        <property type="entry name" value="eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000112">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000113">
        <property type="entry name" value="Translation initiation factor IF-2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000010">
        <property type="entry name" value="Translation initiation factor IF-2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029459">
        <property type="entry name" value="EFTU-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003078">
        <property type="entry name" value="PRK04004.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14578">
        <property type="entry name" value="GTP_EFTU_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="225"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="34"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="34"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="108"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="173"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIO01577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="817" mass="92583" checksum="E84BE07333F872D3" modified="2014-11-26" version="1">MPPKAPKGAPKAAAKKGPPNAMLAKLKMKMELQKAEEERLRLEAEEEERRIREEEKLAEEQRKFEEAERQKERERQKEEERLARKERKAAGKNDALERMRAAGMILPDVDRIRHDAEVRKEGENAAPRPKPKPKPKPIVAVALPPEEEEEEEGEPTELTESDDEIDEDDWEAVMERDERRATRHTNNERIRAERAERKETRAAEKRKAEEENQLKHHVLEKVSNLRSPICCVLGHVDTGKTSLLDRIRSTNVQGGEAGGITQQIGATFFPREALVSATEELIKKHNCNLNVPGLLVIDTPGHESFTNLRSRGSSLCDIAILVVDIMHGLEQQTRESIRLLREKRCPFIVALNKVDRLFDWEPHENMDIQQSVELQKAHVRSEFHTRWGQVKNELSAEGLNSELYYHNKEVRNVVSVVPTSARTGEGVCDLLLLEIQLVQQFMEGKVTYKDDLQCTVLEVKLITGYGFTIDVILINGELHEGDEICLCGQNGPIFTQIRALLTPQPLREMRVRGEYIHHKSIKAAMGIKISGNDLEYVIPGTQLLIVHPNDNKNHIAELVMKDATNINEYLDPDGLGVSVQSSTLGALEALLSFLKSMKIPVASIAIGPIHKRHMHQVLSMKRREPRYAVILAFDVPVSEEAREIAKKNDIDVFEAKIIYHLFDRFTRYMNEYEQREKDRLRSIAVFPVQLKMIAESIHATDPIIIPVTVERGQLRPGTPLSAIRKKDDSVVVIGRVMSMERDNRPVEIGTPGMDLAVKINSGESGVTVGRQFDNSDIIVSHITRQSVDAVKKFKDELKPDDVLLLASLIKVLKVPNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SIM5</accession>
    <name>A0A088SIM5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kish</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_340190</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in the early part of the secretory pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the KISH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702447.1">
        <property type="nucleotide sequence ID" value="XM_010704145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SIM5"/>
    <dbReference type="GeneID" id="22578523"/>
    <dbReference type="KEGG" id="lpan:LPMP_340190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340007100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_340190"/>
    <dbReference type="eggNOG" id="ENOG502S8Z0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10034655at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051523">
        <property type="entry name" value="KISH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009653">
        <property type="entry name" value="Ksh1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13229">
        <property type="entry name" value="PROTEIN KISH-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06842">
        <property type="entry name" value="DUF1242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU910717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIO01647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="73" mass="8665" checksum="ACAFFCA240578162" modified="2014-11-26" version="1">MSALFDFETVLYVLLLIVCTATYLRQFRPTLYHRDSFELYKKLLYKCSVVGDRLSPWVSICCLILAFRIVFVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SJF5</accession>
    <name>A0A088SJF5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_343260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702752.1">
        <property type="nucleotide sequence ID" value="XM_010704450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SJF5"/>
    <dbReference type="GeneID" id="22578831"/>
    <dbReference type="KEGG" id="lpan:LPMP_343260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340039000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_343260"/>
    <dbReference type="eggNOG" id="ENOG502SN8N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="260540at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO01952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="189" mass="19883" checksum="89291F1E1DF7B8F9" modified="2014-11-26" version="1">MCSNAATKSFRPPFKHTVLCHSAASTHAVTRQLYRSQAFAPHAASSFADDSCAATLSSTPASHAPGTAAAVSEVFTTPKTAPEGDVNTLSRDVTTDPLPSAEAAIALVKCASSRRQLQQSIDSRQAELASTKVWSLVAGTLHWVTVSQAALQHLADAQTAGQVEQVLSELRIDPPSVLFSVEEGSFCHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SKU1</accession>
    <name>A0A088SKU1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Abnormal spindle-like microcephaly-associated protein ASH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LPMP_352950</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703232.1">
        <property type="nucleotide sequence ID" value="XM_010704930.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22579324"/>
    <dbReference type="KEGG" id="lpan:LPMP_352950"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350036900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_352950"/>
    <dbReference type="eggNOG" id="ENOG502QSJW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="415597at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052614">
        <property type="entry name" value="CFAP65"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053879">
        <property type="entry name" value="HYDIN_VesB_CFA65-like_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056344">
        <property type="entry name" value="Ig_CFAP65-like_9th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056305">
        <property type="entry name" value="Ig_CFAP65_10th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058536">
        <property type="entry name" value="Ig_CFAP65_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057470">
        <property type="entry name" value="Ig_CFAP65_7th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057467">
        <property type="entry name" value="Ig_CFAP65_8th"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46127">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46127:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22544">
        <property type="entry name" value="HYDIN_VesB_CFA65-like_Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24291">
        <property type="entry name" value="Ig_CFAP65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24507">
        <property type="entry name" value="Ig_CFAP65_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25249">
        <property type="entry name" value="Ig_CFAP65_7th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25248">
        <property type="entry name" value="Ig_CFAP65_8th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24816">
        <property type="entry name" value="Ig_CFAP65__9th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24771">
        <property type="entry name" value="Ig_CFAP74_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HYDIN/VesB/CFA65-like Ig-like" evidence="8">
        <location>
            <begin position="119"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="CFAP65 fourth Ig-like" evidence="10">
        <location>
            <begin position="355"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="CFAP65 seventh Ig-like" evidence="13">
        <location>
            <begin position="863"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="domain" description="CFAP65 eight Ig-like" evidence="12">
        <location>
            <begin position="976"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="domain" description="CFAP65-like ninth Ig-like" evidence="11">
        <location>
            <begin position="1102"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="domain" description="CFAP65 tenth Ig-like" evidence="9">
        <location>
            <begin position="1279"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1522"/>
            <end position="1559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF25249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIO02432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1716" mass="185341" checksum="D293DFFFC0AEBF76" modified="2014-11-26" version="1">MSELPGRKARREQRQRALGVDCVDRLTWKEWEPGKEYKRKILVKNVDRASQSIQLSLPTNRKIFLTPFPEPIMLSSGVSHEIAITFRPTELVELHDAVTITVEGRGSFQVRLDCLTPYAKLTLPSTHDFGYCAVGSTAHAQVQLHNNGTAPVEFSWEVPVPFCILPSHAVLVEGEMIHITLLFTPTEGCTMVARAVCRLTGTDDIIATLTISGIGKHPYICFQEPSTEEGTLVVQMEAQQHRGSNSSSKLIHLYNPSPVPVSVRIRRVDESLMCAFRFTVEGKVALEKDDPNDDGTFLVPRGVVQPVRIHYTPGSPGVIDFSTFQIDCAHGNSLQVELSGIALGPRVTASSSSFDYEAVNLEHIPTVKQRTRYITLRNTSATDAPFTWMNTLPGAAFTVVPHSGVVAAQSSLQVAITFQPTHPILYYRRLYLLIEGAKDVVGVDVLGSAYTSALRPPTLTLADVEAARLRMERGLGLLTPEELASIAAAAAAGDESIDSLQKNGQHNSVPASTLDIWRRIEEDVRSPGVVIRGAKRKMRFPLSSLETANGSVAIDTPFGVDAKPLYTFGGGGRIGSDSRGHLVTVMNTSSVTAVATWSLPAPHMCPYMIAPTQQAVPPHGSAVFQLQCNSSVSDELPPACTLECYVNYESMSAFYLAPDACVLPPQCFTVTCTSASIDVLTSAKQKSPSQQCTSNQISYARQVSLPACRLGGSSYQVIAFHNEAATPVHYKVAGIMLKQVSAVVAPPNTALVTPEREASAAAVAARAEQQEAGEAGEGVFSVYPAAGVVPALSRQLLVVKFSPSAMAQYAATARILWDENLPHSATSTTSAAALSSAAGTTYLSLFGEVCLPQLQWRQAGEGVTTPLSRLSLPPCCISGEAQHRAWVRNPTALPVEFRFDTSTELLGVLRMEPVRGVVPGGARLPVTLFFSPQQPRVFDGFLQLYVQDGTEEAAAPSTMQLQYRQQLRVRGEGVYANVEVEPRIIDIGEAADTREQQAALTLYNSGYCDVQYDVRAMLVHSGKPGGAATVVPRLHNSRGVLPARTHTTVLVAAQPAPGLTEFIVYAIVSGLSTIVADVQDAPTAEEAERHPHCRWRLRAAHPAVQVVDVDFPGVPRPLAWQQLSLNAINAQLATAAAEPGDRSNGVNASFQHYVSGLDPISMDLGVAHKGDCSVCLTVSLQNTGDCPAPFDVMLPTQHEANTERWCLDNAELASLHYIIDHGLVTVAPQHGSIDVGQTIQLEVRYVHDEVGVHRLPMLLRVGRGGRRVAVVLEGRTLPAEVRALNFHHQKVYELMPVALGDMEPPLQFITATNPFDVPVEYSVDLMALQEHAREHYGFPVFQCADPQGMVAPHGTIHIGFYFRPLEARRYHVSVLVQTAQGEGYYVDLVGCGYHPHKVAATSVMQWIEHALVQVPAIPPTLAARVHPAFLSDDVCTLGAVPYFTLCRRTCTLQLAPDCSTSMRYTWQADRPQRGDAQVVMRPSEGVLQPGEKKTLQVLFYAGSTSQVLERLMTCTVAPCAETRDGEEKQPGGGGGRPGRRATATPRPSANPSRRGGSGATSLSLLLQVRVMPRDDYEALYGSKKLNAAYTPILYSSHADPKSFSTPSSVASQTTAAPATTTEVRLVKGVMDELIRSVVAAPAVQNSFIALCAPRHVTYAKMRVLHAAKGTNAKVFPTAEPAVAAAPSWGNASSAVATEEVIEELLRNVLAKTVATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4I3</accession>
    <name>A0AC62A4I3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Iron superoxide dismutase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">SODB2</name>
        <name evidence="1" type="ORF">LPMP_3220020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="XUY36702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="208" mass="23145" checksum="FB117D2F62937425" modified="2026-01-28" version="1">MPFCAQALPYDYGALSSKGISKDQVTCHYEKHHQGYVAKLNAAAESNSEVSSKSLEEVIRTMSGPMFNAAAQIFNHDFYWKSMSPSGGGEPSCKVASAIIESFGSFSRFKEEFTNAAIGHFGSGWVWLVKDKSSCKLKVYQTHDAGCPLTDPNLVPLLACDVWEHAYYIDYKNDRAAYVKAWWNAVNWPHANRCYRAAGGSRYTNSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4V4</accession>
    <name>A0AC62A4V4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">40S ribosomal protein S8, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2420120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="XUY36902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="219" mass="24565" checksum="34F0E14A36261EAF" modified="2026-01-28" version="1">MGIVRSRLHKRKITGGKTKIHRKRMKAELGRLPANTRLGARRVSPVRARGGNFKIRALRLDTGNFAWGSEAIAQRVRILDVVYNATSNELVRTKTLVKNCIVAVDAAPFKRWYAKHYGIDLDAGKKSAKTAAAAEKKGKKSAHAAAEKYDVNKASPKLQREWTRRRSSHKVEKAIADQLREGRVLARMTSRPGQSGRADGILLEGAELQFYLKRLEKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5B5</accession>
    <name>A0AC62A5B5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha tubulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1320180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="XUY36989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="451" mass="49683" checksum="3D47FCCC1FBC5BF5" modified="2026-01-28" version="1">MREAICIHIGQAGCQVGNACWELFCLEHGIQPDGSMPSDKCIGVEDDAFNTFFSETGAGKHVPRSLFLDLEPTVVDEVRTGTYRQLFNPEQLVSGKEDAANNYARGHYTIGKEIVDLALDRIRKLADNCTGLQGFMVFHAVGGGTGSGLGALLLERLSVDYGKKSKLGYTVYPSPQVSTAVVEPYNCVLSTHSLLEHTDVATMLDNEAIYDLTRRSLDIERPSYTNVNRLIGQVVSSLTASLRFDGALNVDLTEFQTNLVPYPRIHFVLTSYAPVVSAEKAYHEQLSVADITNSVFEPAGMLTKCDPRHGKYMSCCLMYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKCGINYQPPTVVPGGDLAKVQRAVCMIANSTAIAEVFARIDHKFDLMYSKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGAESADDAGEEDVEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5M4</accession>
    <name>A0AC62A5M4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tuzin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2020110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="373" mass="42008" checksum="BCE8E1B3B886BCE1" modified="2026-01-28" version="1">MEGAPVSAVAEVSTRVHVQVGRTATNEGRVVGGIVGRVNSNGTLGALMDKSCFAAQVSQDDLVLVEGRARITLERGYLDMVKWIRDAGVHRCTDRERLSSVLYQRGWRVDRLYLLGPSDVHCVSYVKRSVRLLVLERAEWQRDHHAELRALQRERVRERAWRYVIQRYSGFVSANCAALGVLSVFLWNFKGCRRHQRTFQVKRAVSTLTDTDHQYTSSPAEPPPFVERAAEESWARQVLRQPDITHPRIAVVTGLRGCGRSSLLRSAARKEHRPALFVEVRGGEDTLSCVVKAMKVPNLECCGDHLEFIADTFTKAAKVHGERPILALTRREGCELSRVYNESALLASDRRLCHLAYEVALESLTTQNVLLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A624</accession>
    <name>A0AC62A624_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amastin-like surface protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2020930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="194" mass="22191" checksum="6A5C0B5FCE518DDD" modified="2026-01-28" version="1">MEFNPFIIVYAAIQFIAFLLVVVGTALDMFRLQSRENFEDRPCITLWGLKPYCNSIVYSLSSDERFSLCPVRRKRFHMAQILAVVSVGVYGTAFALGVIMLYCCLHLRWVCLLLNIVGFVILPIPLALMVLSYKTDENSLCPKLRDDYDFGVGFYIFATAVGMDFIDIVFLLIPWQYDYLDVTCNSKEGNSQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6C6</accession>
    <name>A0AC62A6C6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATG8/AUT7/APG8/PAZ2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0920180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="XUY37335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="124" mass="12747" checksum="547644016555283B" modified="2026-01-28" version="1">MSAYVSSTPLEARVARCASLRATNAVPVVVEEAQARGGKAHFSALPRETTAAQLVAAVRAFRGVAANKPVTLTVAGCSVSPSATLGELHDACKQADDGMLYVAYTAERSMGAAVCTPCASCSWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6W5</accession>
    <name>A0AC62A6W5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histone H4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0120015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009370">
        <property type="protein sequence ID" value="XUY37386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="100" mass="11374" checksum="0ADD5AE2C102E61D" modified="2026-01-28" version="1">MAKGKRSADAKGSQKRQKKVLRDNIRGITRGCIRRMARRGGVKRISGDLYEEVRRVLKAYVEDIVRCSTAYTEYARKKTVTAADVVNALRKRGHILYGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RH02</accession>
    <name>A0A088RH02_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_030130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009372">
        <property type="protein sequence ID" value="AIN95247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700955.1">
        <property type="nucleotide sequence ID" value="XM_010702653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RH02"/>
    <dbReference type="GeneID" id="22571879"/>
    <dbReference type="KEGG" id="lpan:LPMP_030130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_030006200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_030130"/>
    <dbReference type="eggNOG" id="ENOG502S91U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277671at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="139" mass="16169" checksum="27E3AFD9BF40494B" modified="2014-11-26" version="1">MRYYASGESRESYITGIRPGGRYGTVHDVEKRRDNLPENVFHYIKEGVQREECLRRNEEEARARIRLEMFSKKPGQHRGNVATIAAESGGDAEQSAAMSQLERETQTRERRAALQELYQRDRREWEVRLGARGLATQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RH17</accession>
    <name>A0A088RH17_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein kinase, putative</fullName>
            <ecNumber evidence="6">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_030320</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="6"/>
    <dbReference type="EMBL" id="CP009372">
        <property type="protein sequence ID" value="AIN95267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700975.1">
        <property type="nucleotide sequence ID" value="XM_010702673.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22571898"/>
    <dbReference type="KEGG" id="lpan:LPMP_030320"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_030008200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_030320"/>
    <dbReference type="eggNOG" id="KOG0594">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF18">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="400"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="55"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="183"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="269"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="447"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="624"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="690"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="765"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1068"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1195"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1494"/>
            <end position="1532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="290"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="364"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="447"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="461"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="691"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1069"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1500"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN95267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1540" mass="165269" checksum="409357A06BC19B01" modified="2014-11-26" version="1">MFSGEETAAFSKDRAGGSPAQPTPELSIFQSLLSPSSIHGGNVSQLSLSSAVRMLPTEEGPPTSEANDHHHHHHHHHHHHHHHHHHHHQQQHCHKDSGGDGIIGSKDASSGHNDAGSGVSRGSSSGGGAHDATVKGRPSAIEGKCADANFSLGRPQSGGGQPQHAQPMPEDPLAMASLLSYHGASGDEQDEDRSDEDGGRRHCRSSVAPFGSVEEGGGADDVDNVQPGSPLRHRRNCLRGPPIAAVMTPDTVSGRGVVGERSSSMRLLIAQEDPPLLPHQRRRRSVPKDSITLSSTPSNSSGDEREGQGLEAAQGRRRAGEGADDASSLLPSTLELPDYIPSSALPCPRAACDVKDNVSDTDGDSVQSASGSLHSSPPDVTLWGVDGGLRRKRIKKVSHYILGPLLGEGTYGVVRDCIDLSTDNADRRFSRCAIKIVSGNYAKLSTPTAKLSKASSTSPAKTEDGNDNGHGRHSHSTDRGALAGPLKRTSGMQYRREEDLKRQETFLREMRNLQRFHSKNIIRALDTFTRYSKEYVVMPIAICNLRQLVQQLLRTRWREAVREWRRAQRGLQRSLRHNQSIGAPAAHGDQVQPQPQRSLWLPMVPSAVEDLDVDIITFMADAARGDGEDTDGVSASRSRGSSDDDDAAAGTWDSKANVICHDDRQRRHCGSITTTHTINRCTDRLYWVDTSQSPQQPSSGPCPTFAGGHHHYHHHSDGDESWEDDISDGSSVSTTGTTNSIAVISATPRGLSAAEPPVECDNLVDRSATSAGSNGTEGRPTATAPPGPGASTLHSRPHMSLPTCSPTLLKGIFYQLISGVAYLHQQHLAHNDIKPSNVLLFEDGTVKLADLGSVSDTYNDQGSPLFASPELCKYFYGATTPPASFSKSPQHVGRDAAQSSDMWCCGLILYYLITGKPGPLPVQLRYFRMLNNKQMHQQLRPFALHGDKDDASDTHTDQASLPPVVTRYQLYREIAQQTTPVNLSDLPDMVPPDVCDDMLLSDTPTLNTVEASEGDSEREKAMLPYPPNSVRHLLARLLDLDPLRRLTAEQALRHPWLRIAFRSKMSATSSSSSSSSSSSSSNSSGHQQQQQQQQRKPPSKQAMEEAIQRDVARRVMESRHVQHMLRRDRQRHLQFVADCCNMLNLQIPPEIIKAHAEEPYQEADGDRVRFSSPPAPQVHRPNSLAAAAAAVSGRSTHHGARYTDANTQGLRDDTGGSEWSVTSPNNSAATVTGVVLRDSMRPRVMPPGCIDTKLFLPPSEEDYYEQKSGKAEFDVRVLRRKPLLMAQLDEYFHNVVLVQCGYRTGPDPNYQVMRLRAVPIEDENGGGYHYGGGSGGCRGGAQQPAVMILSGANGGLYRRSPPVGPSSMPPAAALAATGPHYYGTDGANRDGRSTEVWGAGLHRNPGAHVEGRGVATAAAFSAGAAAGRRANVSGACTVTGQPLISTSLSGAAAAAAAEASANRAAAQSRASAAGGTGNGANDVVSSSVLCYGSGSTGSGGRHRAAGRGRRRGQRDASESQSEGETSVAMRESSKCLCGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RH31</accession>
    <name>A0A088RH31_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA splicing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_030470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009372">
        <property type="protein sequence ID" value="AIN95282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700990.1">
        <property type="nucleotide sequence ID" value="XM_010702688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RH31"/>
    <dbReference type="GeneID" id="22571913"/>
    <dbReference type="KEGG" id="lpan:LPMP_030470"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_030009200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_030470"/>
    <dbReference type="eggNOG" id="KOG0120">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10266058at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12232">
        <property type="entry name" value="RRM3_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23139">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="323"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="72"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="651"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="655"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="673"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="701"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN95282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="734" mass="79380" checksum="FD6ECEA3ABB6463F" modified="2014-11-26" version="1">MDIPYPEMMMPMNTQQGFHSNAGGGNFALPFMSGCAPGVMPFGFSGDPIPNGNQNACGGGMSSDQLLHFLLQQQQQQQQQSVSSSSSLPPRERNEELGDMTSAGPNSAPTTTRVLPSVDEFVPVVPKSLMNLVVGGAPASGDGGVAAAGSASAPQQQFGNGQGGALVLLEAPKIGPDADRRAREQRRAHVSGFPLGTTREELEDYFHVLLPEVRRLQTERQIRELAERTGLIKEEGEEAVRHVPATANLASIDEVKSLSVNPGRVKSFSFIELRLADMIDELVGQSAADPHRFLFNSSVDGQTYPLMIRRPRDADPLTGVDESKVVLVGFPPSMPEESIKPVFESYGKLLKFELRNGYAYGEFAELRDATDFRADVHGVVLGNNMVVALPLYDWLKALLVREDIDVTIEDDDPVSGKYVMKQVRERLPETSALGGAGATGGVAEGDAGAGGSSALVVVSEDPEAASLQVMRELLDMSFTLPDMLGRFAVLYPHLRPLYANSQLTIFATPVLVLLNLFDEEELVYDSNYSQLLADIEEEVEKYGRVKRLVVPRREARPKLPEAPKPGVDYDEDDEAAKVAAMAAYSEAKKNFGTELGRYMTKQTHPVWGGYGRVFVEYETVDEAAEAQQRIAGKMFGERTVVTSFLFPDLLKDTNEEATESDARDEEEDGAGGDEAKEAKDGEGDGDVAAAIKTEGGENEPHSSSSQTQNAVEVVGDALDEVAAKTPSLQAEDMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RH59</accession>
    <name>A0A088RH59_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_030770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009372">
        <property type="protein sequence ID" value="AIN95312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701020.1">
        <property type="nucleotide sequence ID" value="XM_010702718.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22571943"/>
    <dbReference type="KEGG" id="lpan:LPMP_030770"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_030012300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_030770"/>
    <dbReference type="eggNOG" id="ENOG502SJ5R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267937at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34491">
        <property type="entry name" value="A-TYPE INCLUSION PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34491:SF150">
        <property type="entry name" value="WASP-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="659"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="819"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1157"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1326"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1441"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1661"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1958"/>
            <end position="1977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2001"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2029"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2054"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2326"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2388"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2447"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2718"/>
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        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
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        <location>
            <begin position="78"/>
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        </location>
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    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="140"/>
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        </location>
    </feature>
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        <location>
            <begin position="178"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="565"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="599"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="689"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="717"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1179"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1216"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1249"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1441"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2010"/>
            <end position="2023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2029"/>
            <end position="2040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="2064"/>
            <end position="2073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2455"/>
            <end position="2495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2744"/>
            <end position="2755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2771"/>
            <end position="2780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2787"/>
            <end position="2798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2822"/>
            <end position="2838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2862" mass="300442" checksum="53F7338CB19111D8" modified="2014-11-26" version="1">MTSTADGVEEATSVLLDVPALASRPLSPSPPPLVSSADAEPQLLKSPPSASCDQQQDVPLPLPLPASPMTRRCRRPLSSASASAHYLTTTTAATARSRSPRNSAAVRSAAPSPSTSLAPPRRQCLQRSRTATTAESRTTPSPPTSVLPLPPPAPSSPPLGKASVPPLRSTAVPSAGGRSTSAARTQSSQQQQRQQRSTQPGTAPRLATAVRGTSAAVSPYRSLIDAVLDEQFTVGPGSPPSQQQQQQAAAAGVVVDAADTILAEVIPSKRRKCGGGVAVRLQQHGAQHLASLGRTEGDLGDGDDSEDDCKIADPTLAPLHQQALRLQPLPPAASASALIEAAALLGSDGGEQAETLADIVAVAPTQSAMQSAVQSTLATERARLLCNSPCTGLTQDAAGGVTGLEAAEARERLWRPTTEPRVVARAFHHTGVRGAVTDRHAGAASTRVPNSMRAAAPPPALPTAFAEFLKVEADAEAAVQGREATATCATERQRHASPPHHTHNVASPRAGASSMSAPTTTLPTSFTLAASLPVMSPAAESAAVLQELKAVQRRLREHGHRLETAAAATGATPPEACPPAAAPPKGMQGLESCSPCDISTNASSASSTATNSSSTPTEHNKRHDSARRTRVVGLRRPSSDYWVAASLTEIVDALDGQRTASLARERRTHKRKRSQANFDPASYARRLLDTTARSSTSLTASDDDDSEYDTTGCHSRGVQEGRCGDGRGKASESSRYHRLSSAPCALGGLSPASMKREALLRSGPAWATAAAELGLTPTEVQDLLRYSLSSTDAAAAWLASARLHTHNVKGVVKAAVDTQDNDDVGRARTERGKKRSNSNDEVGGPPSVAQTHRPHRLASASLDVAAQTALVQRIVAAMPAIPTELQAELSRQRRLLERVCRDVSCMSASAHAAVRARLASPTVSSAAARQPSSVELSTGVRGREGLQTILPTAAEAHKVQAQHEEHQQLLFASLPRPAAQALITASGLRGAAADPSRPLPPFHAVVARPTRHTAPVTPASPMGNGASTPREPYETALHELAERETRHYVSELDRLRTMYDRQLQEERRQRQQERRHYAELLQSQQQKMLRHHRETVHLLQRESRLQQQQQESLVQKLAASQAAAAQRQQTQHEQATKHMLAGAVDVMKSYVTAEGVGGGKQVEMGPPAGVTVAPGVMQKSRRQQQRKRPVGSLAPSLAAAHGPDESDNSGTGRKYTAAGVAVTAGTPPHPSVHGPIADAASRTSPLRRPASTTNAAPSSVSSTATSPSRGMHASPAKQNYEEGAVTPTATGKRGERHHTPDITLSVAPSVSALVPTPAASTQAGVAVAGAGPPTNTPEMLRAVYGGDAGPPPRRPRTQGRMTLPLHVQLPPEEDTTTRQRLGEAALMAELSDLCAMAAAHDAGLAEGTRLYGVQPRRPRLSQPAPSPNTGEAAVERLNQAAPRRALSASPSSAAAKRRARGPDSGKVARRRRAESQWSGSGRNRGGRAVGSGFKNPGPSTGRRWRGTSPYATTGNSSGGVAHRSNLPLPHRFDTEVVSLLCSEAGTAPSHVVASSTAYAVPVAPHDVVTRPAQYSGMWSEAICVGGRHAHGARASDQETADAVVAAAGVTAGRPSIGRPLLVLTQPVGGAVATSGSCTPQEVDAQLRAALHHRASLVRDLRHKKSPCTSPPRSAPPQAEAAATLVHDDGSTGNDDDDDGHTAVNVAGSLPPCDGVFFGASAEVLINATDSCAVGDDSDGALPSSLDVAPVPLVMLTDYTRAWVLYTAAEREVESHAQALAAEDAGVLEAVSRAPEHRRRCQGEENDAASTLVARLPRPASTAAAVCYREKELSYGDPSLQGGSMYVSPRMAAEAQALREARRRLSEIRACFIAPPSLGAASVLGNVSAGRVTGVDIALRDAALVRQLVDATVLSVLETQHQHSQPDLVRQVMAALEHEILRLMLAGCLEEEVERASGAAMKEKAHGRREKAQQQPQLDADLARALAEATLEDAVHAALERSRCGKKTCQAATSPDATAAATSETTVMDAPAARMDAPSAAEVELHESVRIPRTAPTAWLRDVHSPPPQPQEPPPPRDVRNAQSEADTITATATVVLPPPRGDNHAATCFAALRAAEPTPQEVRIVVDLSPVVHHMGTLRDLAAAMPVHDSQQQQYCPQSYPPVQQEQLPSRWMALEDRRDVIVEVETHLAVAEVKAEVVDEHTRVAAPTSDYGGLPAPAVSTTLPTVPPPLPLPVVTVADITSAHVHGTTALADRTASRDPPQLMLLRLLQSALLDQERLQRTNLTDREEEQRQAHKLLCEVAKAAAERRMFAVPPSPSVAAISTVQSKPALPQQLGTNAAPDKARHEDGEAAETAMSRVSAPPSQKPPLVRDPVMEFVLERMRQFGASQEQRLSMRGTGTGISSASPVEDLTVAAQTAGLHDAAPPAETAAHRPLPDPFVRYAASRPSTRNLGSSTTTVSSCSSLSSSLPTSSSLSSSLPTSSSSSSSSSSLLTDQALGRARITGDWYSRAQHTCVPHRISSGAPVETSMAYLRPPTRKARPVLDMQRDDASASTATTHYTTGRNSVVFPSAEKFQEDRAVPTGSSGLLPPRASAEVQAALTAALHAHQQAKRADVSTATLAAGYHVEVDDISLGSPVGNHPYAVSPPVSTAAAVQRSSPAKLRAPPPTWSAMTQERGDARGGSSSGEAKGAVDDVWKPTPSVATREKVVGTIAVVGHRGAREQRATKPQPTSPPRTAAWAYTSLTSTSTSSHSGNGGDPGSGREPNRAYSAQDTTFTSPAIDGDAPASSALPFLPARTRHTTEPARRNSVPPASMPTSQPLPVTTAAAPLPSSPSSLHEHGQLLLAPVLRAQQEQRATES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHE6</accession>
    <name>A0A088RHE6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_040780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="AIN95402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703724.1">
        <property type="nucleotide sequence ID" value="XM_010705422.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22572037"/>
    <dbReference type="KEGG" id="lpan:LPMP_040780"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040014000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_040780"/>
    <dbReference type="eggNOG" id="ENOG502SK1V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267837at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="670"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="944"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1335"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="946"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="983"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1008"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1021"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1056"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1103"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1129"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1181"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1205"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1335"/>
            <end position="1352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1391" mass="146480" checksum="DFECB262C7CC2547" modified="2014-11-26" version="1">MNFTASDRTRRSAAGTDSSSARGRHNRCSSANARCSGDAESSEHRTSSSRRHHPQHRYQRHQQPDDRELSESSLATSSLKERRGSQAQEPQHHSLDDTSARRLSSSQSSRLPPRRHEQLSLTDGSGERQGSFAATPLSSTASEMMRSNSELARPNSVAAVLAKDSTPISSRNAAGCTAVAATAPAPSPSSFRQSPPSSNFSAEPPAVESGNAVYSIASASQSSAHQPASSQLEAVIILSSPTATSLVSLEASTAQPDRSVHSWQQSIRLRAENRPPSLTSAGRSDHSTARSGPPPPPAPRLTSSHRLHAGVANLALSSSSASVRTHASEAASQTSSKPKRASEAPSVSGADKACNETTEGAADGGITPALHPSAAASSAGVSVVADAAVTTPQPPSVRSRTSSTVVGVERRSGPSVCPEGGEASSTARSAASSVHQQLLPRGDSYQESQSRPRHGSGARLPSPASASLTPASSVASTSPLKASGQQASQRSFRAVASLSSPSVADAPAPSRARGSMTPRSLNDSRRSASPLQRRNYQVSVTSHATTAVEPFRLSTECRSTIRRTASPCCASRNPLAEVPAQELQRVINLPRQVHTAPGISRLDITFEEDAKELYRQTHLVDPLLLRRPGRRQFYIPEQADLFGMYPEPLMTMDEDGNEVIAHLAPIPIQGQRCVQPKRRSSAVSPKSSADHDTSDKSASPPPMAPAPSVQRGKATGTDAPEGRNGEGAVVRPGRSLSSFVAGYGEEAAAKGSGGLTPPRRRVISEITASYRRNMAANTGLTGHSRRESLRPNCLPLPGGPETASPASVRLLSPDVMMAVVVSQTPSPFAPMQPTPSSDTSNVMQTSNSDHEYAQSIAARPATAVVPLQDQHQQQQQRRNDVVVLSKVEEYSRRVQSVTSITIPARTFPVTAEVVLQPSLAARAGNHCSHSQGISMPVKPAVVAPSTRVSTSTAVQLDATSMATERRSRRARGHEGAENGAEKAPASSLAAIASPPNEAANRRSSSDRAGPSAAPVAAGAPREPKKTPRDSHRSSATSKSASLPRQAEQLQPAESEALAATASQPTAPTPKTAASRAAVDRSPELQILTARRHVDPSPVPISPLSESSSQPQRARQVMQGPKSTQEMWVSPAAAAASPSISSSDASPSLPPPLRAKPTATASSEPDKPSAPPKGNAAVQARRSSDRVVTSKDDDSCRQHSGSQGREFSTTEEAATEASATPDRCPRVSKRVSALSAISTSLVPSMSMSVTSPCVADYAADGHRGGFREAPLVSDNSTQTEFVFVLDNMQGRQVQQRQQEQLAMSLQLTQLQLQQRLLQMLDAGSYVPYASTTASTLQVLPSPQPDTSANTSPPMQRDQRAAGISTGISPTRQRRGYVVNNSKGVRDALWWAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHR8</accession>
    <name>A0A088RHR8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_030800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009372">
        <property type="protein sequence ID" value="AIN95315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701023.1">
        <property type="nucleotide sequence ID" value="XM_010702721.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22571946"/>
    <dbReference type="KEGG" id="lpan:LPMP_030800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_030012700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_030800"/>
    <dbReference type="eggNOG" id="ENOG502SIWJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267786at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33472:SF28">
        <property type="entry name" value="BROMO AND FHA DOMAIN-CONTAINING PROTEIN DDB_G0267958"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33472">
        <property type="entry name" value="OS01G0106600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="778"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="842"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1176"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1252"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1325"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1491"/>
            <end position="1537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2006"/>
            <end position="2046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2112"/>
            <end position="2166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2185"/>
            <end position="2237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="367"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1220"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1261"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1326"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1345"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1399"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2014"/>
            <end position="2024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="2120"/>
            <end position="2130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2226"/>
            <end position="2237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2237" mass="237946" checksum="C56C6DB4196880AF" modified="2014-11-26" version="1">MNLPSSVKAPDADSPHSFRAESEAATAHKPLNLRSTSPAASHLPLTRSSSSSSLSLSLQLHHSSSLANSAALPGARRRTDNSPLRPPQDAAVGIAELVAPHVRQLYNTEVRSCGHPQRLYIKVPVGLSSRATERDRQGGGAPLRHSAAPDTEGTEAATPRHPTGSPVHAFAPPLAPVSNTTAEATPSARDALHRLPSPPSASPAALVSPYGTESTRVSLGSEPLPVVVTDGVRTPASSASASPAPAETAEMRDTKAHREDENNKQLPHEPQQQHQRRGGSERGLHPAPPLMEAQTLIAAPATFIHATSSILPSPHQRSVLGGTEERDIDVNAPVEDTTHHIASVHTSPAEVHLRQEGVPSAVTPSWAGREAAAATEGTVNYSPPASTASSVTSREELVGDDLDDKAGSDDGDDREVSGDVRSLPESEVEGWLLGASVQPSATAEVEQQERPHSLQLTKAETPEMSPSLSRSGEELQENVSVDTSRSPVDSSLPRKLSTLQHSDDDGDATVEAVVVELAQQQQSRFEDITVAERTIPPAATSYSPVELLEGEVEQALSALANPESSAVSDGSADNDAVDTVMPDTDALEGVGAAAAADVVANVVNTRQLVENSDVSDAEGDCAVEELAESADFSSANDFESAPRSVLADAVAGSEEVMEDVQKQQHRTLIPCSVDAIVSANSVAVRSSSSGRVLMPPPMPRAVPAEMTTGGYAGRISSSEVSRVSGIEADAEAHLRGYLDDNVATCGAARARDTSSLTTTLPPPPSVVHTTDMWRWPPQPASYDRRRHHHHQLRDGGRQQSWPLGALFQRRPVARDLLADVNAMYDEEDSGGKYTAWQPRSLAQGEGSDNRLLPQHASPSAAAAAAPPPSLPSVVTADTLVLAHRRIIADSSLNELVELEREGRRMIIFDMLQDREAVLQEEEVDFSILSLLSHRALTVAAAAVPRPAWVPPLSPSPLSPPTSNSISHSVAASALAGIMVPPPSGAEVEQLRRARALPGCFSLGIVSSALFADELLQREIVEGEEDSARTMLQRLCQCDADALNPCSIFMQEALARQRLMAMAQLELQQTWLLENSPAAGALELLSIGRELGLCSMMENDERRKVIEKAEQLGRQRLQELHWRGVAARLRQCELLRASIDVALRDAIEDALFDETQAREELRVEAIREMTRLLESASGTAVRGATRQRHQQRGTTPQRWNEKAHVLATSVAPLQPSARSAAADRESDAPVGKDDDSDWDVMAEVVSDFYGGCSAAGSDAEQPPVSASSLSSPTTTTVSSSLPISEASPEHHMATTAVTAAAAAAAAAANDGPALVAVDAPNFFEWDPTSNSASSPSTGSKARKPHPSSSQQQQHTSTSSPSLHLTHLTALTTTTTGNTTSVTTSSGGGTSQGKQAPATHASGNTTSDSRRSPTTVLPTEEEQQKLLWGHERVSPAEVSALRHALRCAEAAARDRYRASRWAEVIIEEGKAAPAWQHDHDSSTVVSAANLHDGVAESRSTPPPLSLPKQQHHMDSVDGVADGPRQPRTASHLGHASTTRGPLFINRHTIPCSLCRSPRRNYAALTGKYALQGEPQSSSPLLAAATISTSSPSTPSSCSPRPYAEGDVYAYHPQRTRHSKPARCAAFEEHPDPRVPWERPGEDIGDEAAVSSAEAMLHFFTNSAADAPASASDPTLQRPAREVFSARRSCTLSAAAPSHVPLAATVPLAPASSTAATHTGGPVVLEVIMDRRARGLSLAADVTVSPMSPSTCLSQSPTRARPPQAYAAPTAVWARYVQEQQLVRCVRDRGVTNDDDGERALYTSFATPVRDGGAATQVNPDQSGCSRRRWEHAEDYPGQHVSAPSAPLLITRLPLECGPGVWMSSPRDAHGAVHVVATTTPPCSRPAPAKLADAFSHSARTGDVVRLPTTVAELLQHPQHTRLPRPTSTIYVSPMKRLSCDLAEDRHALRQQPAPYRYVDVFYGNREQPPRRNAQALPPSTSVLVQPYSTSSSAFIAARCAAVREREIQQELRQHLQAPSPSQARRAPPSPSPARAGHTAASRRASSTKFPSALLTTAAAAAGDVEEVLTDESAEPEDFYFDDDDAFMPRSTAVASRVGRHRAVELRCQQLQQSCRGAMRPTARPPASPPAPLSYPQHRQRTSDAASGNHGDDGNRGPPPGGRRLPVPSLSARTSSFSLRRGLMATPLSSPLTGAVPAGAGGGASRPVGFIQPQHPPQRTGAEQQWGQRHPKQRRAHPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHV2</accession>
    <name>A0A088RHV2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_040230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="AIN95350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703672.1">
        <property type="nucleotide sequence ID" value="XM_010705370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHV2"/>
    <dbReference type="GeneID" id="22571982"/>
    <dbReference type="KEGG" id="lpan:LPMP_040230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040008100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_040230"/>
    <dbReference type="eggNOG" id="ENOG502S75M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="433738at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050754">
        <property type="entry name" value="FKBP4/5/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512:SF9">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="277" mass="28525" checksum="4B6C63EF5BFCDE7B" modified="2014-11-26" version="1">MSMTVPSSLSSASVPPSSCPKAAYCLQQAQAAKTAGNAALQAGNPRGASFQYKKVYLHLAEYLPCDVVQSASPVALGYANGGGSDADGNGGLVQMLQEEQRRKQPKKAAAVSGNESPSTTTATASAEAALLMLQAQVTQLYATTLNNLVLANMKLGRYQEGVKCATAVLEQPTLRAALDAGAQSRASAHFSDTPAGKALLRRATCYVKLSEWALAEADICTLKAAAAAAAASGGGAAHPAGGSDALEAAVLQLTHAVEQGRQAEVAKEKRMMRRMFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIA1</accession>
    <name>A0A088RIA1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_061080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703989.1">
        <property type="nucleotide sequence ID" value="XM_010705687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIA1"/>
    <dbReference type="GeneID" id="22572314"/>
    <dbReference type="KEGG" id="lpan:LPMP_061080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060017200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_061080"/>
    <dbReference type="eggNOG" id="ENOG502S2SF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271982at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043645">
        <property type="entry name" value="pATOM36"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19224">
        <property type="entry name" value="pATOM36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="303" mass="32500" checksum="F93F7A26DF7F0A82" modified="2014-11-26" version="1">MLQTATNSNVLPLRGGRSALNHGYSMHTLARKRFAENTSALAVTVGFVLPVLNGVNKQLDKHVDAGTDVSMDELLQIFANSGKDAAVLYADRLARIGCQTAMACALIESKSAYGNAAVYLWDLYPRLHQRYVGAVLSWLRIPVFVSSLLGPKPTAQDVAFLQARVSCVCAFEDSLRRDTITLFGDLLVDTARIMMRRDVENPTEAIARQTVLRVTVTLVGAIGAGVGRAAIGERGEYWGNIAGTMAGPAIAVQLWMVVRKFRVLRPRRSSDGSKGHRHRHSTTEGSRAAAAAAASAGAAPVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIL5</accession>
    <name>A0A088RIL5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_080120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="AIN95822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704144.1">
        <property type="nucleotide sequence ID" value="XM_010705842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIL5"/>
    <dbReference type="GeneID" id="22572474"/>
    <dbReference type="KEGG" id="lpan:LPMP_080120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_080006100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_080120"/>
    <dbReference type="eggNOG" id="ENOG502RYWB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276948at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd23653">
        <property type="entry name" value="mS65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN95822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="269" mass="30583" checksum="E95FC2C5445C62FF" modified="2014-11-26" version="1">MFRSTRCTLARSFRTNLKYPSLVSYNKLPWEVVNHDSTKLHMHLAPNYAQLLTLAAVTNVPHLALAAHLNVPEAERLRVLPGVVYILGGQAAHKNPLSFTAYRVADPTSLQYYGRIHHSLAVIQRVDVCTSADLRLLCLAMHFDGVLTNTSPGSTLDYITTTSQEGRFSLFYYFRPNRPANELTQPFEKFYQHRPFLASVDTFHAALPGKVESWTPVLQIPRRKSKEARLTPEVPYRPPQNYLMGLAERLGVRPGNSFGRRSLMWGTWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIT2</accession>
    <name>A0A088RIT2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_061210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704002.1">
        <property type="nucleotide sequence ID" value="XM_010705700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIT2"/>
    <dbReference type="GeneID" id="22572327"/>
    <dbReference type="KEGG" id="lpan:LPMP_061210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060018500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_061210"/>
    <dbReference type="eggNOG" id="ENOG502SHKR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266816at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="754" mass="82308" checksum="DF7FD5209672ECD3" modified="2014-11-26" version="1">MRLFLTTMECLNSTASGDATLTSNVALFDPGVWSRAGTSAMALRNVSASCVAQQVYQRAVLPQLAQATQAHTVCFRCGPRPPPHLDGFLFHKSHAPPAAAVLPVRTPSPLISLSSSTSSVHMSVAAPPTAQKQTTDSCASDRATAYDSLLALWLRELLSGTDRTVTVTALLLFVEGTAIDMAGGNKVHTPLKMDSGTAQQLRTCEDATEFLHMCESTLRRSTTEFPRCPYHICIAVLVGAHGDPSEGSTVIFLDVASASPESVGAYQQMRLREQITLFGRQLGVEATTARPLTSPLTRSAADQRWLGLLQSCQLSRASLVGLVYVVYDASHDLFDRSGVEEDGCDPFTLASVLHQNALSEAVRNDVLHPPLSPTQERATAPPVRHTTTPFRVPDASPKAQSRKGQQQQHGKRLPPLKCGAAPRAPIHQADEPHIVLGVVSHRGRFTDLLWRIKKEERHARLALSSAEQRARELAEMRWVLSAHPPGKSINAMPMRLAHNVVLVSRPEPQQPYSTPPFRLLTTAMRRSPSTIMHTPESTSLDCTVRRTGPILTRQASPSRTASAKPLTTWRIVPLSRCGTTGTVPQHRGNRQAHSASLRAVVHRHSISDLERRCLSASTPISPSTDFPHVRTCTSARQLSAVEVALLARARLASQRGAPSNSLPRGETERLYPLVHAFHMEMNEQDALMAEELMMRSRLEHKEKNCRKALSGAHVKSVHRGFAPWLSKAGAHPPQAPLSTRARSALPCPSRIFFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIV9</accession>
    <name>A0A088RIV9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">homoserine dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_070290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="2"/>
    <dbReference type="EMBL" id="CP009376">
        <property type="protein sequence ID" value="AIN95715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704037.1">
        <property type="nucleotide sequence ID" value="XM_010705735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIV9"/>
    <dbReference type="GeneID" id="22572364"/>
    <dbReference type="KEGG" id="lpan:LPMP_070290"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_070007800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_070290"/>
    <dbReference type="eggNOG" id="KOG0455">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="67851at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000005">
        <property type="entry name" value="Homoserine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43331">
        <property type="entry name" value="HOMOSERINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43331:SF1">
        <property type="entry name" value="HOMOSERINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homoserine dehydrogenase catalytic" evidence="4">
        <location>
            <begin position="48"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN95715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="269" mass="29032" checksum="BE5ABD6002817544" modified="2014-11-26" version="1">MTANKAMLTRHGAGLLKPATSRTPTSSSFPAMRVCVGFVATVAAGVLIIKTLQSSCHVQHVHRIEGILNGTSNYVLTERRVNPEKAIEEVLRRTPGLGYAEADPSNDVSGQDALMKLCVMRPIAFSHQPNRSTLPVAGIDILTPEMLRDARAKGLRYRHVVRAATEVVATSSCAPSTTAVREEVQSPTRLLHRHLTCSVKPMLLGPEHPLYHMDGRMSTVPEWKDYLGVLTISSPGAGMYPTAVCHDGGLRTVDGGNPPTLKQSGSPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIY3</accession>
    <name>A0A088RIY3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein kinase, putative</fullName>
            <ecNumber evidence="10">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_080540</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="10"/>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="AIN95863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704185.1">
        <property type="nucleotide sequence ID" value="XM_010705883.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22572516"/>
    <dbReference type="KEGG" id="lpan:LPMP_080540"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000015700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_080540"/>
    <dbReference type="eggNOG" id="ENOG502RXXB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF103">
        <property type="entry name" value="KINASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1625"/>
            <end position="2043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="147"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="295"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="479"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="725"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="799"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="906"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1295"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1383"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1449"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1656"/>
            <end position="1684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="298"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="486"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="731"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="753"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="771"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="821"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="940"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="968"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1004"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1296"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1386"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1465"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN95863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2049" mass="213526" checksum="B157EA8D214FE7F6" modified="2014-11-26" version="1">MHVTFSPTHTAADEHYANGTSSSPSLPPSMRIVVVAAAAAAAAAAAAALLTVPATSVTQYDAAAHALTSNGNGGSSGSHTLTNTGVGIVDVLLVVACTLMLVTIALLIVVIRLLKHVAVAAAALRSSAPDIRRNDLRAEVPVTYRSVSLDDDENNNAALHGNNRDSRTQRVEYAEEQQSLLHRARSRGGRTERHHHRSTSPRHQETGQNTILGLFDALSIRLGLSPTAAIEDATSCGKTAAPRSRSRSYRAVDSAVPSLGSCSAARGSPELQCHASLCTDPDAFATVKDETDAFRAAPQSTWHNSSSLNQSGAARKREESAVAQVPPSSEPSLPPAVVAAETSNERKTATPAAANHGGTSPSDDAQMPLFTATTQKDMAVYNTTRHSRYRLLQRIGLGAFSSVYLVQHKDTEKKYALKYILCKGDRERRAALRECEAMNCLQGHPQVIRLVDMFMNYQFQSAPTSPRAADSPAIPATLSGRREQATGEQSSRPRSTAQPRAPAAIAPSVSPAAAAAQSLWSRPSSSAAPSHGEATAITAVANAHSRHRAPDPAASAGTTTMLVAARLKELSDADMAKSASLTRFDGVVVTATPQAPIRAVAMERSTEHHPAAHDEEEDDNVDYSHVDTAAEDECQLQGALSYRYRSPHSTAARGYGSGNGDEDDEERRCVIHGVRPSVKGAAYGAYMADADHASDRRNVVSTFGDRLASIEARDGEELPQLIFSAADREQPQPQGKQSMRTSSSHDRCPLHSVQRTSQSGNNVHLPGADAATSTTPKADSSSSVFAGSAHVLAPPYAAAGGGTRGCGRPPLQSTSRPLREASPTASTATRTASTDASLPARSEAHAGQSRSCGHATGAPGAVVHNASDPTATIDVSVGCCTVEGMAITATTTHNRLPSMACNATLSRSSGASDEHGTLEYCDGGHGMRSSSGGTRRSKKIQSATREVPEPTSQSSRVSLEDCDVDGVDDGRANAHVGSERRRTDRRCDADAEETRSCKRDDACSSATSSSGTQEEPIQPIHRILMPLQSLDQPPNGLTGAPSSGDSKGAALQLQNRTCTLGTGNLTAYNLYANPPTATVGEAPGVVKPMQATGSAEIPLSVAANLHDMGGSTVSTFTPPPPQQQQQLLPSLAASYALARTAASSADVSSAASGTLTAQAPIRYKDFVPPHALITAPPSASRTPVTAMRGNGGVIANSSVEVQEHRQPINRGGRLAPPLYGIPARAGSGTTITGTCGLRPDRLAGAYGNPYLERASGGEPVPPPRTSYAPGGGVRYNSLIVPYVAAPTKSQTAAKGLPAQSSSASSPLMLSASGTGVSAFDERNTGRGQGWHSEVTGAASISQDSYASMSACHTACLEAPRPLPSAAPVVATVVRSTYAPLRHGDVAHPTAASPAASSMTRSSTATLSPPSTPRQQQQQQLPSAAYPAASLIANSGRLSLTAVIQAPHGGQQGECMVSDDSKPRVNVSSSATDSALMSAHAPPPPPPLRSLVSQVSSAYLLREAGGLNGAGVAPSRVRYTNAGSPIPWDAYNANTTTVNAAAAVAVLAGLSPKVDGRTPTVTCTGAGDTSDSKSCTTTRTSCSHISLQDARDTGYLGLVIEYHPMGDLCRYALRAKQQLEMRCHRQQQSQRRTLGRSGVVSMATPRSTASLVTATVDTRTRTTERSSTLQPQPTARNATERDDGGMGANAVEPISPFSCRPSVLTHGGTAAASSLLAAAAAATWTAKVAMSRTDLPLALSAGVGSGGTNGNEHLGDFDNQSTAAVATDPTSDNPLTEAQLLSIAYQLASVLDHMHRQNPPIIHRDLKPENILIKGELSDYLDVPLSAALASTSSTPSSPVPLTNAGGASSQYDTGECSAVCVGGNNDGLNKSSVSPQSPSFASLAAVIEDAANSSWLLPPIRITRAVVPIALIDFGLAIMQDTHSCPHSGRGGGTRPYIAPESWHGGTCTASDVWSLGCVLYALATCRLVAKDVRIMSQEAKQDGFASRMLNDIIEKKYSLAFASFVVSLLVVDPAKRPTAAQAAQCFCIVDNEIRFDLRSPFFSNVLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJ23</accession>
    <name>A0A088RJ23_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_090710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN95987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704309.1">
        <property type="nucleotide sequence ID" value="XM_010706007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJ23"/>
    <dbReference type="GeneID" id="22572641"/>
    <dbReference type="KEGG" id="lpan:LPMP_090710"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090012600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_090710"/>
    <dbReference type="eggNOG" id="ENOG502SMK1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266363at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="459"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="534" mass="57535" checksum="E5187782ED59414B" modified="2014-11-26" version="1">MRPTCACAVRAVRMYAPMRVAATNGATPSAASLAGGSAAISSEVRAARRITEAVLRARANRKLREPQPSSPPAPVPPPAHAKTPGPRSPASERGEGVVKDTVTAEVQTATRLALSYGKSAFMTHLVHQHDKVCERPCTFSASEWDQLMVGDPSTPEASAVTASSDTFSASTPRADTPSIPRAAAGMVGLQRALVKCWDELTDEARVRWITSTPQGRRALQHATKLARFRDVTHGQCSSTNSSAYVVPSMELMLSKYKNTLVQPRLPRAAALAPSPRESTLRMKLRGERDTSANLSPKSTATFTALSSMMHVAFASNASRHRLRDRADAVRREERRKLWHEALVKFLGGEAAFMFVHDVKYLQQPRAELDEALKRESSIQGGEGTGRAGTVAPSTPAAAAAGDTALEEVTNEGAPVDFSDGLLDLCEDLGIRSARRAYVLSRVLPEVDATSASEDPPLSLAEVRDLAKRCSNEYNDLRAEAARTAKEAGFASAEDAVRAFERVHLALAVARVQAKLHMFQENLPLLKNCVNALSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJB3</accession>
    <name>A0A088RJB3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleoside triphosphate hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_090820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpA/ClpB family. Torsin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN95998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704320.1">
        <property type="nucleotide sequence ID" value="XM_010706018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJB3"/>
    <dbReference type="GeneID" id="22572652"/>
    <dbReference type="KEGG" id="lpan:LPMP_090820"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090013700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_090820"/>
    <dbReference type="eggNOG" id="ENOG502QSVN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19623at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010448">
        <property type="entry name" value="Torsin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10760:SF16">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10760">
        <property type="entry name" value="TORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="182"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="320"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="522"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="522"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN95998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="559" mass="60628" checksum="30E57C4E3A5FD6C1" modified="2014-11-26" version="1">MASFLPPQRQLSHISRRQPGWIPPSATAGKTSLLIVFAAAFFLALGSATAAEGQQQQQPLKATAAGASSHVSNSLCPRCPLCSRPGTPMKDWLKYCHTTTGYIFSLFSWGKSTLTGTQRTGGSIREQRQLYPLELPFATDDAVRRQCMRDLQDLLLARVRGQPQVVIPLLDVLRHKLAYPREPVVVHLAGDNGVGKSHTARLVSEALSLRCALDRDVCDAGDNLLIISGTGFDGLSVAEARQRIVGQIIAHVARYPHGVVLIDDLTAMDPVLVSVLAPLFGRASHFPEQLARSSSATAASVRHTTAKPLQTAHQWMKVFGRDGGGGSAKEGNDRKGEAAAGIDGAPPAASEMTSSISRSGQPPPPPLSQLLVFITTDFGRQGRTVGKSRAEIEAMIQHDFADLYGSLLPAYTRTFVYFPFTPAMAEDVVRSAVTNLPCALGERLIASSTISDEAVAFLVQQHRQLWSGKENGHALRRLIEDEIVSQLVAYWETHEEQKAFERLRVRFELDEASMRVLLRTPHASTTTALPPSSALSSTEARAHVRDGVNNEGEEEPSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJF6</accession>
    <name>A0A088RJF6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA replication licensing factor MCM4</fullName>
            <ecNumber evidence="11">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">MCM4</name>
        <name evidence="14" type="ORF">LPMP_090240</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="11"/>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN95940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704262.1">
        <property type="nucleotide sequence ID" value="XM_010705960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJF6"/>
    <dbReference type="GeneID" id="22572594"/>
    <dbReference type="KEGG" id="lpan:LPMP_090240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090007400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_090240"/>
    <dbReference type="eggNOG" id="KOG0478">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251574at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008047">
        <property type="entry name" value="MCM_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF66">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01660">
        <property type="entry name" value="MCMPROTEIN4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="403"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="638"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIN95940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="922" mass="100611" checksum="B5B8D717CDB3C9EA" modified="2014-11-26" version="1">MSAYSRSTQQRSEEYSYIWGTGIAVEVFRDEFRRYLETFTLGQVVTDPSRGTPRPNGREAAAASLRVANPLIAGSSGSTSSLANDTAAAAATTYALQEKYYLKEFLRMHMQGRSTLEVDFTWLQRAAPQLYVQSVHHPTECLQMMSAVAEEVYRDVLLLRHGIEVADDVLITVVAKKLPFMWTLKQLSPQHIEQLLSIKGMVIRISKIIPEIRVACFQCWNCQYQERSVSGDKGRIFEPTRCAHCGKTYSFKLQHNLSLYEDKQLVKVQESPEHVADGETPISIGVVVYGSMVDTVVPGDRVVITGVYRSTPLRLNANTRIIKSIFATHIDAVHMELVRATRATEPGMRKGSFANGNVVGASPHASTPMLATTKDAEVDLSRAALMDTARLDMFHSLAHRPDIYEVLLHSFSRTIWGHDDVKRGILAQLFGGTAKTFVFSERTGGGTAATASSNSAVFRSELNVLLCGDPGVAKSQLLTQVHEIAPRGVYTSGKGSSSVGLTAFVVQDTDTGELVLEPGALVLSDRGLCCIDEFDKMNEATRSVLHEVMEQQTLSIAKAGIIAQLNARTSILAAANPKDSQWNAQLNVVENLQIEPTLLSRFDLIFLLLDCHDAVEDRRLATHVLSLYMDTSHSAHTRRAVTDGSGTAGRHARLQGGSSDGCYGEEDEATQWRSTVSVGQSTVSSADAAGTANTHVDAATGLPVEVRMELDGEVFLQGPPDAPYMPAGILSEYIALARETIFPRLTEASHKRLARCYVELRQARGSSCTVSATLRQLESMIRLSEAHAKMRYSSDVSVEDVEEAKRIISVALKKSATDPTTGLINLDMFHAADPGKNTVEGNMRRLEELLKRRYLAQGRRSIAVAELRSVFNEQQSGAARPVAPAQFVELLALLSGGDVVQSFTATTVTLVMTGVAPAAATM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJG7</accession>
    <name>A0A088RJG7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_091280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN96043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704365.1">
        <property type="nucleotide sequence ID" value="XM_010706063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJG7"/>
    <dbReference type="GeneID" id="22572698"/>
    <dbReference type="KEGG" id="lpan:LPMP_091280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090018300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_091280"/>
    <dbReference type="eggNOG" id="ENOG502S2XH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277400at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="367" mass="38630" checksum="93798FB781311FEE" modified="2014-11-26" version="1">MRTNTRVSLMPTTASGVLCKCSPIAAAIAVTNTEADMVALAGVVRGQRPAMRLSAWAAERYGNGASPRAALAAVATEGTRESTAEVTLQTTAANRSSLASSGHPGPLQSIAEVPRQDQRVPHLPSVTSTELSGVLGGGTCSSLPVPSDVSAVSVIAPSVAATHVTSSYRLRKNISWHCTLCGYHVLAMDQDGTPLPFTISAFGNVLPMTCPRCKLNHTSWQPSTPFSENGDHRNLPTALSNRYAIQASDQQSLRVKDREEMGAADQSDAGVKAASSLAAGGHLAQTGASVGRLATQQRSIPAIPAVSSAQRRAYYCGRCGRRLLRVDANGELVEMDRGKDGQVLPITCSGCKENHSDWVVKPYAVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJJ0</accession>
    <name>A0A088RJJ0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_030890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009372">
        <property type="protein sequence ID" value="AIN95324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701032.1">
        <property type="nucleotide sequence ID" value="XM_010702730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJJ0"/>
    <dbReference type="GeneID" id="22571955"/>
    <dbReference type="KEGG" id="lpan:LPMP_030890"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_030013600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_030890"/>
    <dbReference type="eggNOG" id="ENOG502S25P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272664at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="327" mass="36376" checksum="519E0973EBF94254" modified="2014-11-26" version="1">MFKGLLNPVVESRTARRLATIANSASSGGRPHSRETVRLSVRLLVKLQKHQGPGHTRTPQQRVRRSGLTNPLNLTESWATAQADALAQEEANWRDTDPLRKWKDEAEERRRLQQAEDDAHPGPGSARPSSSSHYGSVNADTGNSAVQERFDALVHRALLRYGPPLPVEVVMNSNVISSTSFASSAHRPTQRSYPDTYVAADRGADDSSAAYYDEVALKLHELMAILRKEEPYFSVRDDCGGVPLSLMVKNCCYLRAFGGKVNYMRFVRRLHAAELQSGGKNHGGGTQNAYEANTAVLSLGKYKMRELPSQDGLRQGPQPWRYTYRMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJU6</accession>
    <name>A0A088RJU6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATPase ASNA1 homolog</fullName>
            <ecNumber evidence="8">3.6.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Arsenical pump-driving ATPase homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Arsenite-stimulated ATPase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_110720</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the arsA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696920.1">
        <property type="nucleotide sequence ID" value="XM_010698618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJU6"/>
    <dbReference type="GeneID" id="22572937"/>
    <dbReference type="KEGG" id="lpan:LPMP_110720"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_110010800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_110720"/>
    <dbReference type="eggNOG" id="KOG2825">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1770at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02035">
        <property type="entry name" value="ArsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03112">
        <property type="entry name" value="Asna1_Get3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="ArsA/GET3_ATPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027542">
        <property type="entry name" value="ATPase_ArsA/GET3_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00345">
        <property type="entry name" value="GET3_arsA_TRC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="ARSENICAL PUMP-DRIVING ATPASE ARSENITE-TRANSLOCATING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803:SF3">
        <property type="entry name" value="ATPASE GET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ArsA/GET3 Anion-transporting ATPase-like" evidence="10">
        <location>
            <begin position="14"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="ArsA/GET3 Anion-transporting ATPase-like" evidence="10">
        <location>
            <begin position="274"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="21"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN96267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="406" mass="43622" checksum="1CD473649EB71A9B" modified="2014-11-26" version="1">MDPTLTELLHSNLQWIFVGGKGGVGKTTTSCALATLFATTPISDAAAPDGTRPRRVLLISTDPAHNLSDAFNQRFGPQPTPVKGLEDTLAAMEVDPKNFTHGALMSSLTGANSGGSASSLSREAEADAVEQTASFARIGAVLKEAARTMPGIDEISVFAEILHYVRTLSYDLLIFDTAPTGHTLRLLALPQTLNSTFDRLMSLEGLAPMLEAASHLIGSSLGAVGGDSVSGCEVATAMPSSSSTAPGAGSAGTGSSQGSWSITADEVRAKALHWRQVMEEVQDRFNDPSRTSFVCVCIAEFLSVYETERLVQELMKYNIGCDSIVVNQLVLKPSSEPPCRMCAARQKIQTKYLEQIDLLYDDFHVVKMPLLSDEVRGVPALKMFARFLQEPYNPDTHGYIDVQESC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJW2</accession>
    <name>A0A088RJW2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Golgi apparatus membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_100260</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696748.1">
        <property type="nucleotide sequence ID" value="XM_010698446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJW2"/>
    <dbReference type="GeneID" id="22572762"/>
    <dbReference type="KEGG" id="lpan:LPMP_100260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100007800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_100260"/>
    <dbReference type="eggNOG" id="ENOG502S8TK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="423534at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013714">
        <property type="entry name" value="Golgi_TVP15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28128">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28128:SF1">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08507">
        <property type="entry name" value="COPI_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN96095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="129" mass="14117" checksum="52058E4D242582E9" modified="2014-11-26" version="1">MPRPNFDDLLHSRPFPLVLKILNIIGAFACGSYSLFLFITHRFNDVRTFAALLYLLGFSIMIPSAESGLMNHPMLASFARFLVSPIGRAFLYVFMGGVILGNGIGGWVIGIYLFAIGVLNICAACILKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLL0</accession>
    <name>A0A088RLL0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_150960</name>
        <name evidence="9" type="ORF">LPMP_330960</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697471.1">
        <property type="nucleotide sequence ID" value="XM_010699169.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702189.1">
        <property type="nucleotide sequence ID" value="XM_010703887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLL0"/>
    <dbReference type="GeneID" id="22573516"/>
    <dbReference type="GeneID" id="22578249"/>
    <dbReference type="KEGG" id="lpan:LPMP_150960"/>
    <dbReference type="KEGG" id="lpan:LPMP_330960"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150014700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_150960"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_330960"/>
    <dbReference type="eggNOG" id="KOG3181">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268474at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02413">
        <property type="entry name" value="KH-II_40S_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1140.32:FF:000011">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.20:FF:000021">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="entry name" value="Ribosomal protein S3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057258">
        <property type="entry name" value="Ribosomal_uS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_uS3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005703">
        <property type="entry name" value="Ribosomal_uS3_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01008">
        <property type="entry name" value="uS3_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760:SF32">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="Ribosomal protein S3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="7">
        <location>
            <begin position="20"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN96818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIO01389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="219" mass="24472" checksum="F72C773E1686A554" modified="2014-11-26" version="1">MGPLSKKRMIVRDGVFYAELFEFLKRELAEEGFSGVSYHITTLRTEIVIKATKTREVLGVNGRRIRELTACIQQRFNYKEGKLQLYVERVEVRGLSAMAQVESLRFKLLSNLQVRRAAMGIIRYVMESGAKGCEVTVGGKIKGQRAKSMTFRDGYMIKSGTAHKSFVDSACRHCYMRAGCIGVKVKIMLPGDSTGRNGPSEPLPDVITVIEPKQITASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLN4</accession>
    <name>A0A088RLN4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 19">DNA topoisomerase 2</fullName>
            <ecNumber evidence="7 19">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">TOP2</name>
        <name evidence="23" type="ORF">LPMP_151210</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17 19">Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 18 19">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6 19">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 19">Belongs to the type II topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="7 19"/>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697496.1">
        <property type="nucleotide sequence ID" value="XM_010699194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLN4"/>
    <dbReference type="SMR" id="A0A088RLN4"/>
    <dbReference type="GeneID" id="22573541"/>
    <dbReference type="KEGG" id="lpan:LPMP_151210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150017500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_151210"/>
    <dbReference type="eggNOG" id="KOG0355">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276498at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.268.10:FF:000010">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.40:FF:000022">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000110">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000092">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.670:FF:000001">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.199.10:FF:000002">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="entry name" value="Topoisomerase II, domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="entry name" value="Topoisomerase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050634">
        <property type="entry name" value="DNA_Topoisomerase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001154">
        <property type="entry name" value="TopoII_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031660">
        <property type="entry name" value="TOPRIM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169:SF50">
        <property type="entry name" value="DNA TOPOISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169">
        <property type="entry name" value="DNA TOPOISOMERASE/GYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16898">
        <property type="entry name" value="TOPRIM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01158">
        <property type="entry name" value="TOPISMRASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00418">
        <property type="entry name" value="TPI2FAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="Type II DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52040">
        <property type="entry name" value="TOPO_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14 18 19" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="15 18 19" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 18 19" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="21">
        <location>
            <begin position="434"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IIA-type catalytic" evidence="22">
        <location>
            <begin position="685"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1160"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="18">
        <location>
            <position position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00019635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00053943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU362094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS52040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="AIN96843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1239" mass="139232" checksum="B46A36FC567D98D8" modified="2014-11-26" version="1">MTDASKYKKLSPIDHVLLRPEMYVGSIETQPTPMYIFDPEKGKMVWETMRVNQGLLKIVDEILLNAADNINNSKGSVRQTYISISISDTGEITVENDGAGLPIVRSREHKIYIPEMVFGHLLTSSNYNNDSTSTTAGRHGYGAKLTNILSTKFSVICRTAGREFHMSWTDHMRMATAPRVSRVDPKEKNVTRVKFMPDYAHFGFPNASISLDMKRVLHKRIMDLAAMFSKIEVRLNNVPFGFETFTDYARLYSLPGPNGSTPPEPFVHTSPNGSVAYVPQLTQSPKRIVGVVNGVVTYNGGTHCNAAIDILDSCLDSLSRNFKKEGKVVDTNRVQRHFTVLVFLIQAQPKFDSQSKARLVSTVTMPRVPKNTLEKYLEKMPFLEAHVNSMDDQLANELNKEIGAGRRLSSKTLISSITKLVDATSSRPDGRNIRTLIITEGDSAKALALNSLSSDQKKYCGVFPLRGKLLNVRNKNLKRLKTCKELQDLFLALGLELGKEYRTPDELRYQRLLVMTDQDADGSHIKGLVINAFESLWPTLLQNNPGYISLFSTPIVKIKVSGKSKEVIAFHSFRDFHRWQRAHPTARYTAKYYKGLGTSTTAEGKEYFADMDKNIMRLTVDAKDHQLLDSVFDAAEVEWRKEWMTKANAFQGEIDIDRSKKSLTIPEFVHKEMVHFALVGNARAIPHCVDGLKPSQRKILWAMLRRHSSEASKVAQLSGYISEASAFHHGEVSLQETIVKMAQNFTGGNNINLLVPEGQFGSRQQLGNDHAAPRYIFTKLSRFARLLFPEEDDPLLDYMDEEGTPVEPHHYVPILPMLLCNGAVGIGFGFATTIPPFHPLDVSAAVRAMINGESAKQVVRNLVPWAVGFQGTVRRGPDDEFIAVGKYTAHPNGRFHISEIPWMTSIEAFRLHISSLANTDVVQRIADYSGANHIDIDLIVRDGTLTTWAECEADLALAQRVYINGTVFSPTGTLSPIDSNLAPVLQWHYDRRLDLYKRRRTRKIGLMEMDLARLKSTRKFVEHFRQGQIDFLNATDDTLTKTCVKLGLVRVDESFDYILKKPITFFTRTSTEKLQEDIAKTQAQIEELKRTTPVRMWLTELDKFDKTFQEYERVLVNSIQKEQRSSSITGGVELPSLRQPLLMLEESAKGATTYRVHACQHETPPPSKRRPGEFFGGAKSSDNAARGVGKRLMGSRAALKAKKLAGNKRRAKMSLTTRAAQLVGAQLGRLLPRLPHFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLV2</accession>
    <name>A0A088RLV2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_150780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697453.1">
        <property type="nucleotide sequence ID" value="XM_010699151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLV2"/>
    <dbReference type="GeneID" id="22573498"/>
    <dbReference type="KEGG" id="lpan:LPMP_150780"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150012000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_150780"/>
    <dbReference type="eggNOG" id="ENOG502RFE1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270454at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="619"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="655" mass="72197" checksum="89CCA21FCA48F8EE" modified="2014-11-26" version="1">MSVIGVFTKGRATGHPSVVSVLRYVPRARVPWQPSRFGRENLADDDMAQLWGTGRYRTGPGNYNSGYSTKKTHTLEDNTISIIPKHELEKFMPDISLGSKALVTPVSLMNARNGHRVTHDLIHSYDPYIGRLQRPAVVDHDNVTVEDPNRVGLNAATLDCRARIYRWLRRGPFFQEDNYFRRSTKLQRNGPVPVSVHEVPLMQRIIRLARGGHLKAACEEYRRVTSVPPVDVYRALTAACIPGAKLADAIAIFEDGNSRLFYVARDGEVLHNVLRCAIRAKHRVRVMWVYNVMVGRRYENVIVRAEVDVIWRYRIASLALEYLLDNNAGEEARVVYDYLVENKLVDCDLHVRLGHVIQQALKEGKTVHVQQDALDGMALSRNVVAVAPQVAVALYARYLENMKEGAAWTDARGLPLTDPTKTDADTNGAAAVAWMKAAFPDIDPAAVLRLARFRRSSKDLMAKDRSVYVQRAAQWVELLSSAHQAREEVPLTYLRKSRPSITNPNVRVAWLPERQRAHALLASDEGFKFAYSGPQTRFVEETFAYAENTLQSRYLAQQPVHTEVTASVALGAAALAVDSSSGSAAPHIPGSPAVSRILHTSVLVDGSLSGSSGSGIAALRSGGSESVKATASPTAGISGRPSSTSGRADLDDAHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RM12</accession>
    <name>A0A088RM12_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_170490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697740.1">
        <property type="nucleotide sequence ID" value="XM_010699438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RM12"/>
    <dbReference type="GeneID" id="22573792"/>
    <dbReference type="KEGG" id="lpan:LPMP_170490"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170010400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_170490"/>
    <dbReference type="eggNOG" id="ENOG502S8ED">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="252579at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="352"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1008"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="167"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="712"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="803"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="475"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="487"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="547"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1076" mass="117130" checksum="4FC71DFFFD6D1688" modified="2014-11-26" version="1">MAYLLDSVASFSSTSPSRTPPRSSSSSPVRKAAHPSSRQRQSQQQQRQLSFAQATAQPMRSANVKGGGDDWLEWPRRSPRRQQQQEHQQDHRSAQEHNPLTAFRGVQHEPAPTTTEGAATYTSTISADDETVSQLSTPLREMREHHGSDWASPSEVLHLRALYQDVTSRYMREVQAVQGELAKAQEECAAYARERRKILELQQAYQDGVVACGRAKEREAQWIEERALLRVQMERVMVENQRLQLYIAKKQHSHNHHVPLRGGATGSHERVRAAVQAVTSAAAATSSVSPSPSAPWPPLPPTVAPTTTTMTGYLASPQSVEGPGATVFVPLPGAPRGTVTGMEQVEATSPYTFLSSESSSPEALQYHAPQQGGRAAFETPPPLVSPPTSRQFALARSTLPTSATGAAGAQPPHSTPLQRTYPSETGDDTRTDQPGVGGDHGGPSLQQQRDYSRRHPCGGVKHDEVPHNSFLMTPSLSSSEAAMSRSVGTSVLGATSGSEGGRLGAGKSARPLRPQRVCLDNEENETDNATGEGEFSPSYARGVTDLSTTSGGSSSPSPAANIRAVLTGGGLMQAPEQRVSRHNHCGSRRLAEQWRGEATAERAAAELPTTTATITTTTPSLGSTTMATTSSSWSLQYLYQLPRTPAEALQEELRMLKELGRLGEANQVLQARLDYVEVTKEIDTKRCEQQYLRLVQAHDQSRHNAAQWELSSQQLESEVRLSETKCAELQNALEDVLQQAKRQQELSQARLVELETSCREALVATRDEAMKKICALRSFLREAAASLATTSASALSPAAAHEVVQLREEAEQNQRTLESLRSELHALRAAHSELQDEHSVLQAEAKMCRTRLESDLESSRELLAAACRDQQCAESRIDELEAEVERLRGAVVVSEGCMHAMEERLRVATDEVTLQQGQLDEASAWQARALGAEEELSSQRSYYEKEIEVYKTAACAMQDRHHAEVEGLVRRCEKLQVRYAAAKVRLAAAVSRSGAATVFTTAGGCAKTRRSRHSKTEGGNVPVSTASPRPPVAITTEASLPHCTAIAYDSLQALRASGQVTEQLIRSLNRSTSSYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RM50</accession>
    <name>A0A088RM50_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein S21, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_110790</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696927.1">
        <property type="nucleotide sequence ID" value="XM_010698625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RM50"/>
    <dbReference type="GeneID" id="22572944"/>
    <dbReference type="KEGG" id="lpan:LPMP_110790"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_110790"/>
    <dbReference type="eggNOG" id="KOG3486">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="278325at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1230.20:FF:000003">
        <property type="entry name" value="40S ribosomal protein S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1230.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001931">
        <property type="entry name" value="Ribosomal_eS21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038579">
        <property type="entry name" value="Ribosomal_eS21_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10442">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01249">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="84"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN96274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="173" mass="17907" checksum="2BED7C77D4A94A87" modified="2014-11-26" version="1">MATIGMFNEEGENVDLYIPRKCHATNTLIEAHDHAAVQISIANVGSNGVIDGTTTTLCIAGYLRSQGESDHAINHIAIDRRIVRIKTGKPKRASKSKSKKPAARGAAAGGAAAQKGARPSAQKGARPPAQKGARPSAQKGARPPAQKGARPSAQKGARPPAQKGAAPTRKSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RM76</accession>
    <name>A0A088RM76_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_111100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696957.1">
        <property type="nucleotide sequence ID" value="XM_010698655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RM76"/>
    <dbReference type="GeneID" id="22572975"/>
    <dbReference type="KEGG" id="lpan:LPMP_111100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000049700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_111100"/>
    <dbReference type="eggNOG" id="ENOG502SMDB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265424at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN96304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="327" mass="34425" checksum="31E9EA7701863762" modified="2014-11-26" version="1">MSLIFVDAYGLALKALDPAAWELFCALEDRILHSTAYLLSHVELTALRPAVTDSTETVSPTAALCVQPSVQSGVRDADAMGTALVASHVLQYLRGTLPAGILHTFTQTLDASATLASAQLAKDLSRVRQQVLSAQSSSSSPCYPELVLTELSAFCQNILVLSALWMSTKFWATLSESSTLSGLVACFLRLSLPPSKDRVVDVSDLEGDSLEPRTSDALGTCTGGALDAVPMEQANVDALCLASTPPSSPLAPVPQEHRSCAEMSSIRIGSAGGREGGADVYDPISSDLLTHLMCLDNGVAEAAESLARAVEDTEIILLRCSGYTIPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RN18</accession>
    <name>A0A088RN18_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome c oxidase assembly protein COX19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_191050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the COX19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698100.1">
        <property type="nucleotide sequence ID" value="XM_010699798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RN18"/>
    <dbReference type="GeneID" id="22574159"/>
    <dbReference type="KEGG" id="lpan:LPMP_191050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190016600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_191050"/>
    <dbReference type="eggNOG" id="KOG3477">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268594at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051383">
        <property type="entry name" value="COX19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21107">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21107:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN97447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="130" mass="15378" checksum="C8222AFF10BD5762" modified="2014-11-26" version="1">MANGVTANNMRVTAKPPDLGSFPLDHYRECKNEIERYYLCLKENDYMTPMCRDPVREYLKCRMDRGLMKKTDVKSFGIPETEFVPTKQHRIDLKEQWLRQKMNQVGVVGVENYIRDDLHTPDGYEKEKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RN81</accession>
    <name>A0A088RN81_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Extracellular receptor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_190610</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698056.1">
        <property type="nucleotide sequence ID" value="XM_010699754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RN81"/>
    <dbReference type="GeneID" id="22574115"/>
    <dbReference type="KEGG" id="lpan:LPMP_190610"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190014900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_190610"/>
    <dbReference type="eggNOG" id="KOG1052">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="888"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="domain" description="Receptor ligand binding region" evidence="7">
        <location>
            <begin position="114"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Receptor ligand binding region" evidence="7">
        <location>
            <begin position="504"/>
            <end position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN97403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="941" mass="102161" checksum="53CD1619100D502E" modified="2014-11-26" version="1">MRTLCSPRPRCSAVALLAAAVYVMLFCLLTSSVRGVVASKSTTESVVPLAASDASPSNATGGDSEGLVWVILIDLSRTAMTEASLSEAVTAFLTNSSATHQYLTTLLRPAPIILDTGGSLLTALTQITALLGDPLTFPRILFLAETADVSASVVDVLRQNDKTSDILIVSTHSSNVRLCDPDMNLRTMCMVPRDMLNVRGLLEVVSNQLNWHSMSLVFSSDGYGEGVSRAVTSQVQTASTTATIVAQTFMSGAASTTDDDAVVTAITKYRARGVGCFLSEAEMRRLHAAVERNNRTASTVFLIASRESLNVLPSLTGDINTTAKPWGAIFVSAYTPPAELVSQGFFPTTHGSAVDEYSAFVLSHLLDGLLMVDATKGAINNMTALRAARFNGYTGKVAFDSIYYQRVETVFSLITAIHTVRNPLVTWSLKDYSSDAHQVNVIPEVTRALVKTSPLRTAKICMTSPSSCVLTQLVMSMLFVLTMHNQNVSGNDGDDVFTFYPVAISTDASGITGLASLIPIARTCTVLTGPGSDTVTMAFTPVVNKFQVPQLDYAVSSDDFTDHPHMYPYFSRSLPKSTFADGAVTHICAHYGWERVIIITSNDQFGISRAQSMRTAMQQQNLYVEATYYLSDSENATVADCMTKIYAKLVSRIIIVVNPFTAAQAETFFRLSDHLTYMRQYIFFMDSALCHAAAASATGDALRQKLPSSICIYPNVTQTRLAELNALYTSSGYATTRQEMRKVMRDGGFLSSVESCDTSSISPYAGFAVDAGYVLIDAVSRAVAANASLNVARSLLPYIRSTSIDNFTGNCTIDSTGNRLYAAYSINIQPWSGAPLFIGTWNSRTSPALEITESSFLWLTNSTMVPLDTFRDASFVLGSALSASPGTIVISVLGFILTISIFYFCYRHYRIQRRIEQALESNQFPVTDEELRRLRGIKDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNG2</accession>
    <name>A0A088RNG2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Eukaryotic translation initiation factor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_191370</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698131.1">
        <property type="nucleotide sequence ID" value="XM_010699829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNG2"/>
    <dbReference type="GeneID" id="22574191"/>
    <dbReference type="KEGG" id="lpan:LPMP_191370"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190020800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_191370"/>
    <dbReference type="eggNOG" id="KOG1670">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.760.10:FF:000038">
        <property type="entry name" value="Eukaryotic translation initiation factor-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF8">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="204"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN97478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="278" mass="31234" checksum="250E4B175970E321" modified="2014-11-26" version="1">MNPNRCSPESAATDEQPLTLLWGTWEMWCDIPHRQQGHGTENSNWLEQVKSIGLFDSAEGFWGIFNCTILPSQLPPNSSYYLFRKHIAPMWEHEANRRGGKWIIPFTSKASGGGGDLQPVDVAWETLCLSAIGELFPGDEEEICGVTVSRGKQRALPSGHVAPLLSEWKLCLWTRRADDRVSQMEIAEYIRKELRLGLLSKETSRDGRNGEIDTPMEMPWSPDRSPAAKTREASGFPSAITYMAHRDLMEARLDFVKGGSRVAPTFRPKYTLAIDVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNZ9</accession>
    <name>A0A088RNZ9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_200630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698262.1">
        <property type="nucleotide sequence ID" value="XM_010699960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNZ9"/>
    <dbReference type="GeneID" id="22574270"/>
    <dbReference type="KEGG" id="lpan:LPMP_200630"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200010500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_200630"/>
    <dbReference type="OrthoDB" id="10604696at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="291" mass="30649" checksum="15E31D758FD45BD7" modified="2014-11-26" version="1">MPSLKHSPPRGAARVVSVRKDAAAATVKVPKLTAAALGLLESGALQRGMCAKTPALHTPYLSTSPSKRSCTSPTTSAPLFRLFSVDLLPTVDSAADVKESEVKFGSPRDARQLSLSLVTDTNIADECYSLTTVVDGSVSFSPPYTLSHSTCSLQHKSHAHFIARACKCGASCTTQTSICATALHTEGTGNSDIATAVSGATYMSPGHSMSSPGNFLRSQPARLWMTVVPQNSHHIGTNMLGSLEETEEVEEAISVASTMAESGQCRLFWDGAEESTSVIEEDIQCNDDVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RP60</accession>
    <name>A0A088RP60_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial ATP-dependent zinc metallopeptidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_201080</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698307.1">
        <property type="nucleotide sequence ID" value="XM_010700005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RP60"/>
    <dbReference type="GeneID" id="22574315"/>
    <dbReference type="KEGG" id="lpan:LPMP_201080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200015300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201080"/>
    <dbReference type="eggNOG" id="KOG0731">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005745">
        <property type="term" value="C:m-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000352">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FTSH 7, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000018">
        <property type="entry name" value="Putative mitochondrial Mitochondrial ATP-dependent zinc metallopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050928">
        <property type="entry name" value="ATP-dep_Zn_Metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655:SF1">
        <property type="entry name" value="ATP-DEPENDENT ZINC METALLOPEPTIDASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="372"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="33"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="80"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIN97600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="790" mass="86021" checksum="A72D01D580362F47" modified="2014-11-26" version="1">MLYTRALVVLSRQPLAAYGLPAGNASVRFCASSALPPSSSQSDKPAEAAKASSEGTQVSPAAKQSGVDTVAANTVVAAGTPNRQGASSLSSEKGGVSTLAPVSVCPSSTGAEASVKEPTPQLQGGRTSPPKQPTPPVHEANVNDVFAKDRVVPRGFEAFYAKNIVSKMLPQRTPTDSVQRAYTLSPQERALIAQIAARARLQRTWRHLGVLSMLLSALIGYRWYTAQARLDADVSNYSAVVVDVPSHTAVYVDDNGRFIGVRNFIDFTTFEKTCDPEKDVLIQFSTYYPWIPMLLLCLLPVLAVVNAGFNGSARMITMAAQAEKSRFTFKREMSVSTRLKDVAGLTEAKHEVVEVIDFLKQPERYQALGAKLPKGVLLDGPPGVGKTLLAKAVAGEAMVPFVSCSGSEFEEVYVGVGAQRVRELFREAHNCKPCVVFIDEIDAFGRKRRSDGNGSSRGTLNAFLAALDGFKDASGIMVLAATNRADILDNALTRSGRFDRKISLEKPSYKDRVAIALVHLQPLHLDPSSSLQNYAETVAALTPGCSGADIFNVCNEAAIQAAREDKEYVGAPHFHLAVERVLVGLEKSAVKYTPHEKERLAYHEAGIVVLNWFQSDTDPVIKTTILPRGRHRTGVTQKLPQNTYISTQERLLQRIVGQLGGYVSEEHFFSDVSTSAAGDLQMATNMARDMVCVYGMDPVHIGHMGFELDRDDTLQKPFGPEKENAVDIAVETIVQSCLSRARALMQEHLYHTRVIAGQLLKQETLNAHELWLALGDRPVMTKEFQTYLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RP82</accession>
    <name>A0A088RP82_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cystathionine beta-synthase</fullName>
            <ecNumber evidence="4">4.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CYSB</name>
        <name evidence="8" type="ORF">LPMP_170210</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-homocysteine + L-serine = L,L-cystathionine + H2O</text>
            <dbReference type="Rhea" id="RHEA:10112"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="4.2.1.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.22" evidence="4"/>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697712.1">
        <property type="nucleotide sequence ID" value="XM_010699410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RP82"/>
    <dbReference type="GeneID" id="22573764"/>
    <dbReference type="KEGG" id="lpan:LPMP_170210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170007500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_170210"/>
    <dbReference type="eggNOG" id="KOG1252">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270224at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004122">
        <property type="term" value="F:cystathionine beta-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000003">
        <property type="entry name" value="Cystathionine beta-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000118">
        <property type="entry name" value="Related to CYS4-cystathionine beta-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="7">
        <location>
            <begin position="16"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN97059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="359" mass="39007" checksum="96313714F924B255" modified="2014-11-26" version="1">MTSANPHDHILADALEAVGNTPCIRLNRVPQRHGIQCEVVAKCEFLNPGGSVKDRIGKQMVADAEKNGTLKPGSVIVEATSGNTGIGLSMAAAIRGYRIVITMPKKMSHEKETTLQSLGAEVIRTETALPHDHPDSLIGVARRLRDEKGYVLLDQYSNPSNPGAHYEFTGQEIYNQCGGKVDMVVISAGTGGTITGVAKKLKELNPSITVVGVDPVGSILADPEHVGEHVMYHVEGIGYDFVPDVCERKYVDRWVKTRDQESFDLALELHREEGLLVGGSSGSAMAGVLEAAKDLRPDQRCVVLMADGIRNYMAKFADNNWMIEHGFREGVVTRPTYEALAKQLEEAKSKLAKYESGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQV7</accession>
    <name>A0A088RQV7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Proteasome regulatory ATPase subunit 5, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_220590</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699060.1">
        <property type="nucleotide sequence ID" value="XM_010700758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQV7"/>
    <dbReference type="GeneID" id="22575105"/>
    <dbReference type="KEGG" id="lpan:LPMP_220590"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220010900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_220590"/>
    <dbReference type="eggNOG" id="KOG0652">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9443236at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000009">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000037">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000347">
        <property type="entry name" value="Proteasome regulatory ATPase subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 12" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="224"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN98353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="444" mass="49573" checksum="8D9F4AB725CD6AD2" modified="2014-11-26" version="1">MPSAKEVSEARAYAQAQEEAAEKRKLQNISEAELNELDTLTNDQLRTRARNLHQETQTLRSFENRSKQELITLKRDVEMGKKRIKENNRLPYLVASIAEVLDLSDDEDEAEELAVGRKKPERKQKSAVVKTTNRYTVFLPVAGLVDAERLSPEDLVGVNKDTFLVLDKLPPDYDSRVKAMEIDEKPKEKYTDVGGLDKQINELIEAVVMPITHKEQFEKIGIQPPKGVLLYGSPGTGKTMLARACAAATDACILRLAGPQLVQMFIGDGARIVRDAFALAKKKAPSIIFIDELDAVGSKRSDEGKHGSREVQRTMLELLSQLDGFGSSDDVKVIAATNRIDVLDPALLRSGRLDRKVEFPMPDEEARASILEIHSRRMNLDKDVNFKELARCTDDMNGAQLKAVCVEAGMLALRHDRTYVAHEDFVEGVAAVQARKKTNLNYYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQW2</accession>
    <name>A0A088RQW2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_220640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699065.1">
        <property type="nucleotide sequence ID" value="XM_010700763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQW2"/>
    <dbReference type="GeneID" id="22575110"/>
    <dbReference type="KEGG" id="lpan:LPMP_220640"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220011400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_220640"/>
    <dbReference type="eggNOG" id="ENOG502SB91">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="274732at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="105" mass="11963" checksum="4AFF1DE29F97EA96" modified="2014-11-26" version="1">MLRACLWDHVTLPYTPPSPCVLFYLVPGDPVWRVSVPNARGEYPDLVPGLPYQEWHGMEPHYLQEYAPPSLNIHQSAEVAWEELPTPPFDDFKRFLASSENAAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQW5</accession>
    <name>A0A088RQW5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="10">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_220690</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="10"/>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699070.1">
        <property type="nucleotide sequence ID" value="XM_010700768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQW5"/>
    <dbReference type="GeneID" id="22575115"/>
    <dbReference type="KEGG" id="lpan:LPMP_220690"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000049500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_220690"/>
    <dbReference type="eggNOG" id="KOG0534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000032">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000009">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF131">
        <property type="entry name" value="B5 REDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0274">FAD</keyword>
    <keyword evidence="4 9 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="6 10 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="11">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN98363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="246" mass="27660" checksum="ECBA9FA6D3A186D5" modified="2014-11-26" version="1">MDVYDESHNTKVFRFALPEADMPLNLEVASCLSLRFFDKDGKEVIRPYTPLNRSDQLGYFDILVKKYQGSKMGTHLFSMKKGDTIDIKGPWVKLPIKANQFKAIGMIAGGTGITPMYQVARHVLHAPKNNTEITLIYANERKEDVLLGNELNELMETYPRFSPYFVLSKAPSDWMGGVGFVNREMIKSLMPAPNRAGDCTILVCGPPPFMAAISGDKDFKSNPPSQGELKGYLKELGYMPKMVYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RR91</accession>
    <name>A0A088RR91_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytochrome c oxidase subunit 10, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_230420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699200.1">
        <property type="nucleotide sequence ID" value="XM_010700898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RR91"/>
    <dbReference type="GeneID" id="22575246"/>
    <dbReference type="KEGG" id="lpan:LPMP_230420"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230009600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_230420"/>
    <dbReference type="eggNOG" id="ENOG502S2KM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268515at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="119" mass="14334" checksum="CBCAE65710CD9DF2" modified="2014-11-26" version="1">MMRRFTSRISAFTAMPAVEQIRQFHFPLTSPPIDIEYLDSDPLEFAVRTEARNWGFDDLQYMRELAFVRINNNPSIGDFRTMTPEERRDLFWGSDRQDFFRHITYKLTGNPEHLYHRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRA1</accession>
    <name>A0A088RRA1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase subunit a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_231790</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699334.1">
        <property type="nucleotide sequence ID" value="XM_010701032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRA1"/>
    <dbReference type="GeneID" id="22575384"/>
    <dbReference type="KEGG" id="lpan:LPMP_231790"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230026000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_231790"/>
    <dbReference type="eggNOG" id="KOG2189">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264220at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026028">
        <property type="entry name" value="V-type_ATPase_116kDa_su_euka"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF63">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001293">
        <property type="entry name" value="ATP6V0A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="376"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="511"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="538"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="602"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="710"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="56"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN98627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="775" mass="87609" checksum="9BBE48CAF5F97468" modified="2014-11-26" version="1">MPREACSGLWRSEDMVVLSLHMQREVAHDAVLKLGEIGQFQFHDLNKDVSAFQRDFVQEVRRCDDMERKLRFLQDEIDKAGVATIVDSGAEDETMSSLEHKIDEVYAEVVELNEQYQALIEERNRSKEHLEILSRDFGGASGDGLLLVTGVIPKERIPLFERLVYRVTRGNSVMRVDDIDKPFYNINANEPVHKSVFAVYFSAPRLRERLIKMAEANAATVYNYADSEQHLISMHASLQQQVDTITQTLHQSAYRQRQVLLGIAASCYEWRRAVVTEKAVFATMNMLKFSGSTAIAQGWAPVRARDDIHTAIAEAEYLSGAQVGTIIEELETKETPPSYFKTNKITASFQSIVDSYGVARYKEANPGVFTIITFPYLFGVMYGDIGHGIILTLFAAFLVFKEKSFEGQPLNEIFSMIFGGRYLLLLMGFFAVYMGLLYNDMFGFSIEIFTSAYRWPQLPPDGPDGIVYPSFPTGRPSVKPYSPVAFGIDSAWSETENKLEFYNSIKMKCSVIIGVTQMMAGVVISLTNYMYFNDNIKVWFRFVPEVVFLSCTFGYMCVLIIVKWLTTWENTHDAPSLLETMTNFFLAPGTVILPLFSGQAALQVLLLLVALACVPCMLCVIPYVEKKEHDHKMQERATHPPAEGEGEEEDNFEFSEVIIHQIIHTIEYVLGCVSNTASYLRLWALSLAHSQLSEVFWSFAFLLTVEYDNGNGICIFVGFAVWMAATIGVLLGMESLSAFLHALRLHWVEFNNKFYAADGHAFEPFDLAESLSKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRD8</accession>
    <name>A0A088RRD8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Clathrin coat assembly protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_240020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <location evidence="1">Clathrin-coated pit</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699344.1">
        <property type="nucleotide sequence ID" value="XM_010701042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRD8"/>
    <dbReference type="GeneID" id="22575411"/>
    <dbReference type="KEGG" id="lpan:LPMP_240020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240005100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_240020"/>
    <dbReference type="eggNOG" id="KOG0251">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="44015at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005545">
        <property type="term" value="F:1-phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03564">
        <property type="entry name" value="ANTH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.150:FF:000015">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000063">
        <property type="entry name" value="Putative clathrin coat assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.150">
        <property type="entry name" value="ANTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014712">
        <property type="entry name" value="ANTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048050">
        <property type="entry name" value="ANTH_N_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045192">
        <property type="entry name" value="AP180-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951">
        <property type="entry name" value="CLATHRIN ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951:SF5">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-BINDING CLATHRIN ASSEMBLY PROTEIN LAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0168">Coated pit</keyword>
    <keyword evidence="2" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="6">
        <location>
            <begin position="21"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="445"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="469"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN98637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="486" mass="54106" checksum="DE091CA7D768E525" modified="2014-11-26" version="1">MNNTDAKQSAGYFKEKATIGLSTFSGNDVVKAILKSTSHLLKAPKEKYLQKLVAASYGHYGSEMKEGLPINEFIVRQLEKRSHTHNWIVVLKTMVSFHRLLCEASDSMVETICCYKSVFKRSRIKNLADSADGAGQAFFITQYMAYLEERCVMQSALGRGRRIEIPEFEEFLKTLNVELLEPVFEILLRLLEAVPVVEFREAVVNNFCTMEAYQLLVRDGKQLFQHLAKRVIFVLDGFEEFSLPVKRRWLDLYRRYASAFASIKQYFDSILCSSRVFVEPVPQLKPLPVSLLARLEGNIRASEVTKDEPCTLESLGIRCGEDVRVDTNEEKILPPLASEPAVAEQPDAVAARTLGAPSFSLDDLFVSKQEPSKPMQPASIPVSWPSSAPPTTSLQCGAEQCQVNTFAPGNWSTGAPQNWETGIPTTFQVSVAQQQPFFSGGVPLAGENASEGAAQLASKPTRLPAPSKKPVDPFKELYDRSHLDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRF7</accession>
    <name>A0A088RRF7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_231130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699270.1">
        <property type="nucleotide sequence ID" value="XM_010700968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRF7"/>
    <dbReference type="GeneID" id="22575318"/>
    <dbReference type="KEGG" id="lpan:LPMP_231130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230018300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_231130"/>
    <dbReference type="eggNOG" id="ENOG502SHRH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264958at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38148">
        <property type="entry name" value="BAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38148:SF3">
        <property type="entry name" value="BAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="25734" checksum="303E46F22DD3508F" modified="2014-11-26" version="1">MLKISPADEKTVLIKKLKHACTNYDAAVKKYLAAVKGLDSTMEALAISLRELSQEEDSELARNKVDRFCTAVDRHMANASVGASGHNKPRPTSDEATPSSAGYPFANYMSDLTREATMIMDEFKEMLKAAEKSKLKQDDLVSKYNKKRLEVDELELKLAKKNQGIDSNSKFSSKVADRDALKAQVEAGKRAFSSTYSVLLQKRTEVLTRVVDSLQTYSAKYYISLSKTMQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRL6</accession>
    <name>A0A088RRL6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_231650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699320.1">
        <property type="nucleotide sequence ID" value="XM_010701018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRL6"/>
    <dbReference type="GeneID" id="22575370"/>
    <dbReference type="KEGG" id="lpan:LPMP_231650"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230024500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_231650"/>
    <dbReference type="eggNOG" id="ENOG502SG6T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264116at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="134" mass="15117" checksum="96EFA97733FA9DD4" modified="2014-11-26" version="1">MQPISSAVPVDTYTAPRANTSYKRANGEAPFSRGRVSDRELPYVPALLRPQLQCFSGDDIHALELRIEYQARIAARDQRINARANRVSTEAHAAVEQRSNVLRQRAARHAKAAGEVRVKKIQEDYHAMGMRHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRU6</accession>
    <name>A0A088RRU6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_231720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699327.1">
        <property type="nucleotide sequence ID" value="XM_010701025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRU6"/>
    <dbReference type="GeneID" id="22575377"/>
    <dbReference type="KEGG" id="lpan:LPMP_231720"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_231720"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="224" mass="24523" checksum="4661CBE5913BDF6C" modified="2014-11-26" version="1">MECAPATLLKRTEDDAHKRRHLVARYGDDGAKGFLRAEAYADHVRQERHSGSGQRHEEVSVMLTPVPQRCTCVVHVFAWILILLSILLVILCAIIAVSAWITLGVQKGLRHPSSCCRRLGDFTLCSGGLLAADAGCGSACVVLAVLRVRRVSRDALVMLPCRFVRPAVSALLCTVMPFPSLRRRLVVGHGQRSHDVGVRLDGLLHTILHRTFHAVCAVRGVPSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRU8</accession>
    <name>A0A088RRU8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_240340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699375.1">
        <property type="nucleotide sequence ID" value="XM_010701073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRU8"/>
    <dbReference type="GeneID" id="22575443"/>
    <dbReference type="KEGG" id="lpan:LPMP_240340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240008600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_240340"/>
    <dbReference type="eggNOG" id="ENOG502S855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270615at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="289" mass="32685" checksum="664D7220716F0281" modified="2014-11-26" version="1">MNAYMHALRLRVRDAAHSCWTAAFPSDRPSGAYSIYTCIINSGLLVWSFAVVFSRPCETVVMRWVYAGMAHCFINMIFSVAVMALTRRQIAVGIPEERSQWRVFFSNPIVKVYLLYLVWEFVWMIAVGQFNGRYPHATCSSHLNVQVAFLAFYLLIGFFLFYSTFTTERCRRPRWRHFSAIRYNDLYCTRSQHSVRWNDERTAVGAVGEPVVFDCGAMSHGEGTERTTTFDYASIMDDSTTVPGDGQDDSSRAAPGCRQTRGPALRISASTGTHRSDSTSPPLPIEQSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RS04</accession>
    <name>A0A088RS04_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_250520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699624.1">
        <property type="nucleotide sequence ID" value="XM_010701322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RS04"/>
    <dbReference type="GeneID" id="22575700"/>
    <dbReference type="KEGG" id="lpan:LPMP_250520"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250009700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_250520"/>
    <dbReference type="eggNOG" id="ENOG502SJM2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267418at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="527" mass="57146" checksum="9D5AE9903E28B8CC" modified="2014-11-26" version="1">MEAVSATTRDGNETSWSVLSVLHVFHLAHVALTVDADSSSCVEEMSTAELVACVRRLLCMGQSHSSSVDSPAPKQEVSAPYVARALLLRLHRLVEAHERFLAWMRTRPSVAVTGTPDDAAAEDAFLADAAAFLHTLPPPDVLQASAPSPPKTERREASRRSSYAQLLSANLYAISTFVDVMVVAPPGTSPRTLTFSSLTLRRELRSLPQPIEAAALSLLYYLITLTVDVVESSVLCCCRVAGFHFAYEDEGSLVRFAQMSVDFPAATTSAVQLSASPSSCTYVSSLHALLYPVLQQEGSHLLERLLRCEQREAQCLGKTADADRIHRRLLARHVLRRLGHLFFHPLRADRTSAGMTSHTTAMAASDRTDAAIVTWMAEQLQRMIYLSSPTAERERSDDTSQGFSAALAGKEYRPCRFEAESLAELLRLLIAQIDADSSPLPSGGAYVCGCSNDSICSSTGSTVRPTSSTAEGVIDLPRMLEYLVLLSPVIEAAPAPGSGALARFPEREALMKARECVVRFSLHASPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RST0</accession>
    <name>A0A088RST0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Frataxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_251080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the frataxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699677.1">
        <property type="nucleotide sequence ID" value="XM_010701375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RST0"/>
    <dbReference type="GeneID" id="22575756"/>
    <dbReference type="KEGG" id="lpan:LPMP_251080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250017000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_251080"/>
    <dbReference type="eggNOG" id="KOG3413">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1897642at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034986">
        <property type="term" value="F:iron chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.920.10:FF:000010">
        <property type="entry name" value="Frataxin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.10">
        <property type="entry name" value="Frataxin/CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002908">
        <property type="entry name" value="Frataxin/CyaY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036524">
        <property type="entry name" value="Frataxin/CyaY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020895">
        <property type="entry name" value="Frataxin_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03421">
        <property type="entry name" value="FeS_CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821">
        <property type="entry name" value="FRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821:SF2">
        <property type="entry name" value="FRATAXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01491">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01219">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55387">
        <property type="entry name" value="Frataxin/Nqo15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01344">
        <property type="entry name" value="FRATAXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50810">
        <property type="entry name" value="FRATAXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0410">Iron transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN98970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="188" mass="20658" checksum="BF051579D969EA4C" modified="2014-11-26" version="1">MKWVRLHQRVALRAMVMTTTSYSVGSLYSLVNTTRSFMTASAMTVARRAVATTGPSEATTNPHIVHYSKLGMDGFTDIKFNTAADELLELIETKVDALDSAAVEDVSCNGGVLTIETAERGVFILNKQAPNVQLWLSSPISGPHHYDMITVTQDGHERVSWKSNHDGHDLVKKLEEELMEAIGADVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RT59</accession>
    <name>A0A088RT59_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_252270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699797.1">
        <property type="nucleotide sequence ID" value="XM_010701495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RT59"/>
    <dbReference type="GeneID" id="22575875"/>
    <dbReference type="KEGG" id="lpan:LPMP_252270"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250024800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_252270"/>
    <dbReference type="eggNOG" id="KOG1302">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262287at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043155">
        <property type="entry name" value="VPS33_dom3b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="597" mass="67398" checksum="2A8B237C512A5612" modified="2014-11-26" version="1">MTLPNDTSYFVEGANQVPKQEFLSTLSRVYEGHGTAIVFIEQHILSALNRLGIAARDFGRDKGVVGVFLFQNTINYVSADNVVYILNPDLSNVRSVVVHLLSYTQRFPSAKPTILYVPQKTLIAEQVMEDEFKLSQRFPTLHIASLDLDYVFLEEKVFTMELPLSFKSVFAEGDLSNLTWIARLLLKLQTGRFGAIRHIRGKGSHAAKVVQLLQRMQNDIGNDFITDIPSEVETLIIIDRSVDFITPLMTQLTYEGLIDELYNIENCEAQFPFSLGESSGVGASERVLLNSTDRMFAEIRDKNFAGVGSVLYQKSLWVKQNYDKRKEVHHLKELKEFMKGLPEMQEMHRLIGIHTNVATEISKTTQSTDFRKRILIEQNIIQQISESDTLKYIEDLVFRKEKFENVLRLLALLSLVNGGLRERELLSLKENMMLAYGIPHVITTFFLLERCGLLCVQSGKGSSYRSVFKQLQTWNASVADEQPNDTAYAYRGYAPPLVRMVDTLLRNPQAWDAEDDAVSLLPGEKKELLNDVEVAATTKAAIVFVIGGITASEVSALRFVEERLSSGATPHRLFIGATDLISGNRMIRSLLPFEPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RT84</accession>
    <name>A0A088RT84_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_260440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699865.1">
        <property type="nucleotide sequence ID" value="XM_010701563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RT84"/>
    <dbReference type="GeneID" id="22575947"/>
    <dbReference type="KEGG" id="lpan:LPMP_260440"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260009200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_260440"/>
    <dbReference type="eggNOG" id="ENOG502SB4I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="243664at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="34277" checksum="947017D13C614B9A" modified="2014-11-26" version="1">MQTLALYPLTVAAVSRPVTLTLGTHGRRVSVAMREPQRTFAAMPPPSPSALSSMAVAAPEGDATATSSCREDSLAGPAAPPPPHLPPAQMVKGFRSGTRFKLSPTQVNEKNVPSAREVGQMIPTLQELHAQLPDAQELEQMFLAPKSVLSANEVSGLSEGSSERAAAITASSTSSSLLQKTTGPLENFLFGPPKDESAVAAEVTPTAASQQRLLLQRHLLACRALFWGTAYALLGFSATVITTMYLCGYYSLRDLQQGMRDKVARDEERLRTMAAAAVTAQDAAADTVVEHYVIDLSHPVEAWQQIQEIWGNVQRLADAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTP0</accession>
    <name>A0A088RTP0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">intramembrane prenyl-peptidase Rce1</fullName>
            <ecNumber evidence="10">3.4.26.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_262660</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic sidechains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.26.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase U48 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.26.1" evidence="10"/>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700085.1">
        <property type="nucleotide sequence ID" value="XM_010701783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTP0"/>
    <dbReference type="GeneID" id="22576169"/>
    <dbReference type="KEGG" id="lpan:LPMP_262660"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260031500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_262660"/>
    <dbReference type="eggNOG" id="KOG4130">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271604at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039731">
        <property type="entry name" value="Rce1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1/LyrA-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046:SF0">
        <property type="entry name" value="CAAX PRENYL PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046">
        <property type="entry name" value="PROTEASE U48 CAAX PRENYL PROTEASE RCE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 13" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 2/Lysostaphin resistance protein A-like" evidence="12">
        <location>
            <begin position="121"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIN99378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="285" mass="31604" checksum="48DC442F170B2735" modified="2014-11-26" version="1">MDLLLCAGASAAFISTFYVWPRERRFISSSINSLGGASLDPTVYVDRNSDEAIRRRTISLGFSCVVSGVYLAFGTASSFTLERQSSWLRPVIRSLFSTLLLFAGPIAEMCYLRTFEAPDRALQLWRNYVICPMGEELFYRGVLFSLLHRRSSAVRIGVSAVLFALSHIHHLVSLASDAYRRCEDNETDRKDLDGRERACWRSAGRTICGVFVFTTLFGLLGGYYYEHVCEGSIIAIAAAHALCNIIGPPELTVLRGSQFTAFEKAASATLYVAGVVGWAWTLLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTR5</accession>
    <name>A0A088RTR5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_270270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700115.1">
        <property type="nucleotide sequence ID" value="XM_010701813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTR5"/>
    <dbReference type="GeneID" id="22576203"/>
    <dbReference type="KEGG" id="lpan:LPMP_270270"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270008200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_270270"/>
    <dbReference type="eggNOG" id="ENOG502S80P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="263475at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="562"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="665"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1058"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="665"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="737"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="767"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1077" mass="118781" checksum="352C8E193DD82BCA" modified="2014-11-26" version="1">MHVVSGGASRRVGRVSDDDYKASSYEETDTSDDWFSDNSEDYVPLAFDYINSNPRRHAGAPAYSKVPSGLEEVGEHESISFSDIPLEVYVERGRTHRHCGPGSKDSNHAEVTSLSSNDEYEDDISSTTSDALSVGFERRKRFHNVGKIKPRTHEASDAESSVFLSDEEEAPLNAQLIHTLIKRLRNPSDEVLLEAFDFVDFSDENFKEELEPLKQIRELLEKKASSPIATATKCDREVKKAVQSLPPEKAIAAKLKAIKSRQIRSSQSQSRLYTGGETEMEKAEAISDLVRRLKEPNTQVPLHVLDEVNRNSQSFDIVHALQTPIHAYMEAKEVLQQTLGENVMSTQSTLDDQIKTTIMSLPSEEAVAAAKRTVKSYTMPSSSSNGDAIRHLVARLKESDQSVEQCEFEKLDWNDRNFSRELEPLQQIRTCMEAKEALQQTSSENVMAIQSALEDQIKTAIMSLPPEKVTAVKTQILKMRERALAKAQGPQAVKVGKLSASAGTMKRLEDSVIMSNPKKKWKTKEGKLSASSCQVKQVDLGIISSQQPAYAAKESTALLAPAKKTRRTRRRCDRSVSISNVQDDTPPGEIVENDQELPESGESPLLEAGTTQRRLSHVPSRPAGMKKRERRPRNCRQGSNISFGSVPMEEPGVIQEEEDKLVGIKRKTRRRRAPHKLGRSLSMTSLPDLEAGEVFEEPTLPAGKSATPSNTRNVTPAPLAIDTKAKPRRLRPDPHGGSTQFGQPPSQVDGDLKDDKTAPQGKAHSVSQRKKRRARVNHNSRSCSFLEVVVEEAREVQDGNFTELKGAEPQHETLPPKRSKRLLRRCRPGGRGNGRALDYSEPEIGEADQLGDAQYFNAVPVKGRWANVHRTRSTHTSMIVELESGEIVERPDETQILYASSGGGTPPPDEANARRVNGRVIPAKAQKLSDRTCGLASTARRRRQRLHMSKELSVSAIPEDLAGEIVEKVPDLLAATAPVSGSFSNGRLPKAFEGPARLLPLLNGTERGPLRYADPPISSLRLSKKSRSGVMMPRVDVSFILETMSNTPPPPFNTLRRSAEAASRGAMVAAKAPGGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RU70</accession>
    <name>A0A088RU70_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_270830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700172.1">
        <property type="nucleotide sequence ID" value="XM_010701870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RU70"/>
    <dbReference type="GeneID" id="22576259"/>
    <dbReference type="KEGG" id="lpan:LPMP_270830"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270015300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_270830"/>
    <dbReference type="eggNOG" id="ENOG502RHV0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271658at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="869" mass="96181" checksum="977E8C376C238ABB" modified="2014-11-26" version="1">MLRLGRRRLAVVTATAITDAATKLNALLDMTNRTHPVPHGEMKRFLKTEVMPILAGTELDRRGNSTDLRHFLGQLTRDAAFAAVIIGARPGASFLQTIVTCIKEDHQRMRFLPKMTSPQASKIIEYLCKAGVTDAEVYPVLISRLNFSSLHELGRVMFALTESGFHALNMLVVVPLYAGEKWVLLFNKAKTSKTMSSCNAFDAVRILRALSKSCRTYVEECRRATKNSMTDIPHESLNLLRNNLLRFIFENASALRGAHWLNVARALLNFPSEFNELWHLVRDYPAIENEVQSARCVPAGITNASSSHDAAVLYVVNCETVGAAAMQRVFQYAEQRTGVPDAEVGSPISAEFPFDLSYPDLVKLLPLLDQFPSMTSASQTQQRVELVLRVVCTNVHHLRLQDLVTMLQVLRRLRPSTKTTAAVETITDEVSNRLTASSPEQVLGVIPFRTVAQLAAALAALRVTRCDGFVTLVATSDNIFPSSLTVDTALSFINALAALKMTRPSLCHGALESILRSMLNFYTRQLKKGPMLDAFPIYVARILRGCVLLDYIPPVDILRSVLLGSAEASLRMSEEVHGAGGVLVFDLSRSLSHFLKQARTTAPEREKDLWECGVLQVVLPLSIACSEDTVHAMERHQQVASSSHTAVSWRSTVEMLALFVDPQMDSTDRGVMVQRLQEAFPEVEALLRVSAMATRAHLHKCSHHVRHGDEARQRSRQTPFNANCNIHFLSALLIFEYMVFHANTQAARPFPTSANQVSTTTDDKVEKDRATLAALKGRYCDFLSAPLSKSVPDTPMDIVRRIFECPLSGSVASSTAPPSTVVLLEKRDAVEITTTLPFALSLVMDPGPVNEFFTERCMSIMVGDAEELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUZ0</accession>
    <name>A0A088RUZ0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA repair protein RAD51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">RAD51</name>
        <name evidence="11" type="ORF">LPMP_280560</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the RecA family. RAD51 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700397.1">
        <property type="nucleotide sequence ID" value="XM_010702095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUZ0"/>
    <dbReference type="GeneID" id="22576501"/>
    <dbReference type="KEGG" id="lpan:LPMP_280560"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280011000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_280560"/>
    <dbReference type="eggNOG" id="KOG1433">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251254at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990426">
        <property type="term" value="P:mitotic recombination-dependent replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19513">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000008">
        <property type="entry name" value="DNA repair protein RAD51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000092">
        <property type="entry name" value="DNA repair protein Rad51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011941">
        <property type="entry name" value="DNA_recomb/repair_Rad51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003301">
        <property type="entry name" value="PRK04301.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02239">
        <property type="entry name" value="recomb_RAD51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF39">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="Rad51 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="9">
        <location>
            <begin position="132"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="RecA family profile 2" evidence="10">
        <location>
            <begin position="311"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN99690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="374" mass="40850" checksum="CD7EFFBB3EDEAF67" modified="2014-11-26" version="1">MQTRSKAKTRRGRPSAQPVEEVEVMESQPQECLQNEEQVFQPQQGTGVAEPNASGFRVIQILENYGVASSDIKKLMEYGFYTVESAAYAPKKAILAVKGISENKAEKIMAECAKLVPMGFTSAVAYHEARKEIIMVTTGSREVDKLLGGGIETGSITELFGEFRTGKTQLCHTLCVTCQLPISQGGAEGMALYIDTEGTFRPERLAAVAERYKLDPEDVLANVACARAFNTDHQQQLLLQASAMMAENRFALIIVDSATALYRTDYSGRNELAARQMHLGKFLRSLHNLAEEYGVAVVVTNQVVANVDGSAQMFQADAKKPIGGHIMAHASTTRLSLRKGRGEQRIIKVYDSPCLAEAEAIFGIYNDGVGDARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVE7</accession>
    <name>A0A088RVE7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_261010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699921.1">
        <property type="nucleotide sequence ID" value="XM_010701619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVE7"/>
    <dbReference type="GeneID" id="22576004"/>
    <dbReference type="KEGG" id="lpan:LPMP_261010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260015000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_261010"/>
    <dbReference type="eggNOG" id="ENOG502RX86">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="711"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="583"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="747"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="777" mass="86983" checksum="28811E36B420AA13" modified="2014-11-26" version="1">MLRRSVKTRGKCRESASTTFDQSPWSTLQPLTLSLSPPSSTHARFGLRRTMNTVSSLLFSSCPTAHHPMRWVSRKSIEEQLPSNIKVDPNAPAIAAKDGEGLGRDAFSSGINGIYGNRAESAMRGMLGPQGQADARESRAVPILGRASVQGTKYTLDRSTVFENWRFRCPEPVGWHLSMLGSTTCKMVNDVNEAVESLQLQIIKGCNVFEIDGAASEIHQSIARGIYEALQAFELDRNGFVMVARCGLIKQPRFQDEITRVETSNTAAARNRIIPIFERYKASSLPSTSLKSGFRISELDDSQLARLNLRRVDRTTAAGLSPDWLDAFFTNVAYNTRLECIDVLLLEGVHTLFDGRPDEHVDDDILQLFAYLERQVKEGVLQYYGVCSPHLAPPVPRNYPEMPPDALVPDKYRTPPKVPATINLYRLMSLAERAGGADHHFRFVQYPFNLTQHQAMSSPLSYDANHTLATLCKALGLTAIGYSPLEATNLMQLPERYHNFPMEADLKALRMNFFTVCERSVLKEMEIKDTIDKGPSTLPPLEHLFVASVYLAAQRQFTNLFFFTDWANYYMTPRFRRAMTRFKEASNADLKEWAKQYEQLINDLLRMRQRMFQHKHGKQAGLISMAIDYASPTLARCPMLNQKAINFATYGCDVLLCGFHVSRYFHEATELNPAKDGNLPIPEEELLALCKAEAVSYANVSPPHPYMLEPLIGDGKISKQPSKGSEHLVPIDPQNPKFPDIPEELQADNSSSDAPVSADDPIESLPKAEAAEKATKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVI3</accession>
    <name>A0A088RVI3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_261510</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699971.1">
        <property type="nucleotide sequence ID" value="XM_010701669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVI3"/>
    <dbReference type="GeneID" id="22576054"/>
    <dbReference type="KEGG" id="lpan:LPMP_261510"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260020500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_261510"/>
    <dbReference type="eggNOG" id="KOG0144">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="104"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN99264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="221" mass="24226" checksum="FB77266FCDA7335E" modified="2014-11-26" version="1">MDTAVTNLSAHAKPWAPNGPTQQQPPLQHPRSNSNQYSQDNGVSSGHGSGVQRGMRAGGNANNGSVKNLVTPGQHPYEYGNLNEMLHTMQQQQPQQPKLSSTAAKLFVGQLPFECTEERLRNLFSAYGNVEHIHILRDNSNRSRGAAFITLSTVQEADTAIFTLHNRYRMLTNRAIQVSYAKNSPNISPFGTHSAVEVHQSNPTNPLPDVAGLATQMSRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVX2</accession>
    <name>A0A088RVX2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_270430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700131.1">
        <property type="nucleotide sequence ID" value="XM_010701829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVX2"/>
    <dbReference type="GeneID" id="22576219"/>
    <dbReference type="KEGG" id="lpan:LPMP_270430"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270010800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_270430"/>
    <dbReference type="eggNOG" id="ENOG502S3D9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="242319at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="464"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="557" mass="62024" checksum="210C58D98BA297F1" modified="2014-11-26" version="1">MPFNSSCTQVLLLLPEELRDEVLCGAAEIIVERGSRNRCFLHVYSEEERRAKIEDIADRDDVVRQAHEKRLSELRWARDVLWADLRVRRFVRYADPILWPAFDSLSKVVNVVHQLIFCEDGDNTAVLKRARDVATASDILRREARLPGLHPLRETTLKGKATLYDVQRRRKRSREAWAATMPSVLLRVDEEEVDSVAWIAEVKQVAYTVSDVLQLQLATTPLTRLVELLSQPQNSLACGASVPSVSAVRRQWRGLLDKHRQWAEYHSLFADVEEACRGWGASEACVARDVHTALKSGSSVQLRTGVHASVLQRVKLYLLLSTRPRKLDSVAAAEQAAFAALCPAQSWAECVEEGLVRIVTLPPTGRTPARFDALVRQLFLSPALCDVPFAQCCTMSEACRISADLQVLHVSSAFNPFVVVHGSRVSNGFAGDASCFRSLEHDRDRLVTERTHAQLRQGLQETPSRGTTASAAGGAARHPTLLQPLQRAPSRITGDAAVAAFNRALISALAVAPLSRAEIQHSPLMREYKDAANYEAVLKVALKEHAEFKGRKYQLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWY7</accession>
    <name>A0A088RWY7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_303120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701334.1">
        <property type="nucleotide sequence ID" value="XM_010703032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWY7"/>
    <dbReference type="GeneID" id="22577365"/>
    <dbReference type="KEGG" id="lpan:LPMP_303120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300036100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_303120"/>
    <dbReference type="eggNOG" id="ENOG502RUT6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="274824at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO00534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="315" mass="35217" checksum="39FD2633A8F7B598" modified="2014-11-26" version="1">MRGQERIWKAAPLPQSFHASLESGNWLRALQIYQRHPYHTPPADTFDLLKAVMHYTGVGVEDVKARFNEKLRLSASLQRRKSEEVEWSLFWEALNKGDGKMISDALSGASVSGTTQQIGMAEACAVLLKGAGKEWHTRLVDDLPFSTVSRCSLLHAALAEKRPDVAAEMLSHARVTRSDLNSLWPLIAQCTWEEVLRMISLCPKNAVPYNKALPFILKDGCSLQTLSEHLEHARVLGDADVVSPLLAYAVEMGDWSYVERCVGHLVDIGKIASSARDAFGHLCKLHGPKRVCQRLLEHHVELSDMTIEDLESLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RX18</accession>
    <name>A0A088RX18_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_302730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701296.1">
        <property type="nucleotide sequence ID" value="XM_010702994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RX18"/>
    <dbReference type="GeneID" id="22577326"/>
    <dbReference type="KEGG" id="lpan:LPMP_302730"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300031900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_302730"/>
    <dbReference type="eggNOG" id="ENOG502SEWK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="258719at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="21729" checksum="462F9BF995D9E065" modified="2014-11-26" version="1">MRQRKRASDVPASPVLLNPNVDLSEEWRAMNTNHGEYRDEQQPRTLSEFREQLRRIHKARNKRSLESEEEEDTFYRTVDGKPKDYALRFIFEWLCTANPTKARLRVERLYWIAGKQFLYGFFMSGVGTILMLVGIGCAAQYCVEKSRGVGVMLGALLLCVPGYYSLFVLYMYVSCRGQYTFLQLPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RX79</accession>
    <name>A0A088RX79_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">2,3-bisphosphoglycerate-independent phosphoglycerate mutase-like</fullName>
            <ecNumber evidence="8">5.4.2.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_282360</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.12" evidence="8"/>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700576.1">
        <property type="nucleotide sequence ID" value="XM_010702274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RX79"/>
    <dbReference type="GeneID" id="22576681"/>
    <dbReference type="KEGG" id="lpan:LPMP_282360"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280029800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_282360"/>
    <dbReference type="eggNOG" id="ENOG502QR26">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="113620at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16011">
        <property type="entry name" value="iPGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.10:FF:000025">
        <property type="entry name" value="2,3-bisphosphoglycerate-independent phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2130:FF:000001">
        <property type="entry name" value="2,3-bisphosphoglycerate-independent phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2130">
        <property type="entry name" value="Metalloenzyme domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004456">
        <property type="entry name" value="Pglycerate_mutase_ApgM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042253">
        <property type="entry name" value="Pglycerate_mutase_ApgM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31209">
        <property type="entry name" value="COFACTOR-INDEPENDENT PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31209:SF0">
        <property type="entry name" value="METALLOENZYME DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10143">
        <property type="entry name" value="PhosphMutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-glutamylcyclotransferase AIG2-like" evidence="7">
        <location>
            <begin position="8"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Metalloenzyme" evidence="6">
        <location>
            <begin position="686"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN99869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="834" mass="89395" checksum="28F949F5A5477447" modified="2014-11-26" version="1">MSTVYHLIFVYGTLQRGENDYPYWLADEAEAVFVARARTVSRYPFFVSLPPDHSECLPCVLNFPDCNVSGCAQVEGEVYLVSAKMKAWLDVLKDIAGGTHVSVPTPVELCEAPSASFRARGGSTAASLTWPGTVAGEAVTVTAALYFSAKGYPEDWSSPAPRSSSRLISKFSVASMLRLYGDRFNGGVPAHLRETQNSAKAKVMQAELNALPEAYWPPSTIAYRAATAKARAAQADEEHTSDMPLIPCYGAPLFPKPMILFIIDGIGDNTYRELGGRTPLEVVAGVPVPSRCEYSPARESAFAHSLSVTEEMLVDSAAAGAALCETVNEHVTPGINVVTRHGVSGLMDPYMAGKSCGSDTAHLSIFGYPPTTYYRGRGAYEALGAGLELEDEDVAFKGNFSTFADRTEELWGDEDPALEAKAVLSTSSAHQYVTHRRCDRDFAAEGPVLCNDLNGTTVATDLHGIPFEYPHTIKMLYATEHRCGVALSGARRVVRADGSSAVLGMLSDKITGTDPLMDGQLLLHCKPTVGEGHPEYAAAAYTCRLVEAASAVLTRRLKAHPVNEARRQHNRAVAARLADEAGTSGSNTVARKNVANLVLFRGAAKKGWVPTFVVRHGLHGLILAPTCIIKGLGICCGLRGEVCHACDPTGQESLRGATGDYHSDLMVKVRAALHALRIECPSSHEAAVTAALQSTATTAQQASRIIDPQYNFVVIHVKGVDNAGHDRNLKLKLEMLRRSGLAMEALWSALPAGATMAVTADHSTPLGLGDHCCEPVPVSVAVKRATSDGALSAFPIDGVEYYSEMMAASGALGRFRGGELIPLMKRVHHHYHYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXE2</accession>
    <name>A0A088RXE2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_283130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700651.1">
        <property type="nucleotide sequence ID" value="XM_010702349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXE2"/>
    <dbReference type="GeneID" id="22576758"/>
    <dbReference type="KEGG" id="lpan:LPMP_283130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280038400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_283130"/>
    <dbReference type="eggNOG" id="ENOG502SSCV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267651at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="121" mass="13316" checksum="83A36189BCD644EB" modified="2014-11-26" version="1">MNRGVKHGRVETPSPAPSSRESTSPAPLAESLPAATNVRTSKRQEAKKYLPDTLLPESAASTSVYSDESFHIESSREREEAVLAEGRYLSGDALKNFLQKNFVDYIDDELFDVAALEALED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXM5</accession>
    <name>A0A088RXM5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_310720</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701461.1">
        <property type="nucleotide sequence ID" value="XM_010703159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXM5"/>
    <dbReference type="GeneID" id="22577498"/>
    <dbReference type="KEGG" id="lpan:LPMP_310720"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310012500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_310720"/>
    <dbReference type="eggNOG" id="ENOG502QYNF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF157">
        <property type="entry name" value="NODULIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="721"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="760"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="793"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="825"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="859"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="905"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="84"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="464"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="597"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="957"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="470"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="598"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="618"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="630"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO00661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="976" mass="107363" checksum="A6157D37A4A48976" modified="2014-11-26" version="1">MIHADSLAHPNAAGDVALTSPRAEARRSLRVSFAAQKLNNSRKTRANRTASQQYELSFISSDLHHGEPLQRLTMPRSPLYPASIIPLADRKRETPGSEDSSSDTEKDPITADIPDIHGNTSTTDDNFRKKTTQDAASGALLIYPKKIDNLRRFRILFAGVILSISGSTQGIHSVFGVLHLQQAYQFNARSMAIVYLSGVSVGLFTLPFGALYDWFGPRVVVALGSVIAALGHLLFVLTFGGHIPPTVLNCAVFYAMMCWGCYALNVAVLPAVLTHMPRDRGQPTGLLQTFTGLGASVFACLFRGFFKDDFAHLMWFMFAVTLAAGAGGVWYLEDAPYVINRWQQRRITPCEQLRAHLIRNRYMSQLVPKRRYIIMAIILVLLNLYLTIQAVCVAYLAADITPGKLRGIAIGAVVIVLLILVLVLPLDSIDGLSEQDKQVIAEAKAKEEELLMMQEERYRGRHLQAHEAQCDSNATPTKGSEQPSHCPDEVGQEGLSSDREPFVDGDLPDSPERSIAAPAHGVQRHAQPSLRLDGECDADANVEKSALIEVMVPAEPVSAHSPKAPHQRSEPLRESLGLPLHKLTGTERPLVTVYMPDRTNDLGEEPPHSHCSSPLFEAQQQPLRRSTGATHDDGHHHSEPPQSHPEDSFLTVHLGGDYNSLHASLSCTPSADSDPEHVELRCTAPSTYSNPRVETIMLCGEVYVVPVYQTTFLESLTYLDLWLMFYTTLCVWGIGLVMTGNWNIQIMVKARYGAVEPKHYILFAAMSGVSVAGGRVFLGIYERALQVLRARAGTVVVPTLIYPVASVGLFLGVLFWIALPDGKVLILPYILSGFFYGVSTSATFYVIGTIFDRDMGMHYGFCYLGGSLGFVLCYWCAWYLTYEREASPSTLGYCVGARRCMNRAVGIYLALAFSSIASSYLVHRRYSKLVRGKLAQRRVIVPRIKRALVASGFCESSDGVKKSHSNGMDGAFGANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYH8</accession>
    <name>A0A088RYH8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_321690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701854.1">
        <property type="nucleotide sequence ID" value="XM_010703552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYH8"/>
    <dbReference type="GeneID" id="22577910"/>
    <dbReference type="KEGG" id="lpan:LPMP_321690"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320022500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_321690"/>
    <dbReference type="eggNOG" id="ENOG502SDHP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="246306at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="523"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="666" mass="73112" checksum="F50403BF5E0446A8" modified="2014-11-26" version="1">MNDAFESRLSDMRARLSNLSHTVEQQEDEHHQRRSFGHRYLMEKRTADPAARPPVAQSITSFSTSPSSARLSRPTTANSQLPQRNGVSERDVNQVYSVPKNNASPGHHFNTNSMPGPLTYTRTAKPVSGLNAMLQLARRHASISMSEATTATVIVSSTDAKLTPVPNDSVTIPSKAVDVNPLQDTCESTPAPLTPGGAAGLHSYRFQERFPSPRQLTPLSAVNARTMVPRDEEGRTPYHCPREELHLTNEDAKVDHNVTSREVVCFDAFRVVQERLRQKMKQLTMSSPQSGMPLSTRDAPVESAMSGKATAPRETTSRGFSPSLAVSDFEDSSPSPRPPRGTRSETATPMRSPDEHGVLSNDTPSPPSTSLRYQQDRGDASMDVEVLPASAELDTENVSKTRRPTHGFLHDFVANDRVEAAAESSKSQWLQGRMPSSQARVIDGPLDAFGGPAVFSGRVARAPSSGAHSKRTPVEQRGDSREYRRPPEMAIAERFKGARGRSERTTTGTARRLPSAPRHTRPRYASSSMSATRSSASREGSASTAGRPYRSSSKAAVRQKPISLNVEANILCAVTGAELFALLRMRGLIESEGDTEEYRLPPARCHRLYVTTEEHRQLKLLRQSLRSLGAEEQRPDVPSYQRVTVSARARNAEFAPPPPVSHYMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZ07</accession>
    <name>A0A088RZ07_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleoside triphosphate hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_323300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702014.1">
        <property type="nucleotide sequence ID" value="XM_010703712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZ07"/>
    <dbReference type="GeneID" id="22578071"/>
    <dbReference type="KEGG" id="lpan:LPMP_323300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320039500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_323300"/>
    <dbReference type="eggNOG" id="KOG1491">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2551">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="424823at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000534">
        <property type="entry name" value="Serine_hydrolase_(FSH1)/50S_ribosome-binding_GTPase/GTPase_of_uncharacterized_function_C-terminal_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013646">
        <property type="entry name" value="YGR210-like_G4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF1">
        <property type="entry name" value="OBG-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08438">
        <property type="entry name" value="YGR210-like_G4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="2">
        <location>
            <begin position="236"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="471"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO01214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="968" mass="103732" checksum="882ACCD2A6200BE1" modified="2014-11-26" version="1">MPVRVLCLHGSRQTREIFQNQLSLFQDDLAHIAELVFLEAPHVLPFITAQDDILTRSWCSTDDKEDYSAGDALVASAMQPGGPDTDLAFTIMFGFSQGALMIYRYLWLHARDTAVSSQLRGVIVAGAQDPRRMLPCSGGRTLSQLPSDRAAGSFAGPPVFGALPFLHLIGRKDTIVAPEESAAFAQVCSSTSRALFHEHAHSIPALKEVRTAVREVCLAASMSSVKVAEALEARAEELEMVRSMYEEGCVLTRGDETLVRIPLFTDAESLLASSSSSVTVSLDASTVHALERIKVCFHVPWSYPSTLPMVEITGGPTWHSVKYERWAAGMVVRTSAYLADELGVGTAMLLPAYLYTAGLAQEEVDILLDVFTKEACSGDRAHGCCDGGADGEAAVSQLADPWATEDELLRQTYITEAEAKAAEVLLAEAKRNRDCRRPATDGGDDGRDAESEVVELEAPTAAGGGGGTCTLTIGLIGKPSAGKSTFFNAVTNPADESDAARVASFPFTTIEPNIGTALAPLYCPCATLRAAELAPADDDATGVTAAACSASSCNAALSSGLTGTLCDAAYGHVCALGSDRFRRHPVKVKDVAGLVQGAYQGKGKGNQFLNDLCDADVLVHVVDGAAATEADGTACTPGQGSTMEDIAWVRSEVHSWIYDNLRAKWTSLVRQPTKLRTMFSGYRSTPAFVDRVLRRVGIANDIALTAILRTWGPQELHAFVALYIRLRFPLIVALNKADLPAAAGVAEALRQAYPHEVFVPMTARIEWLALQLSRKGYIDYTSGVASLSGTFGHGDAANLDKSVHQELYDVTSFFRTTTPSQEVLSSPLLRTTTGVQDVLAAAMEACGVMLVYPVRTFHPVTSLAHCLTFKLGSSAGRVFDALVHLKLLEGKLVRFEVIDLAPVKRLLLQQLMASLPSIPSNEASTAVPAQPKQRTVELPTLVKTLRKTEVISSSVVLARILSNKFQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0R0</accession>
    <name>A0A088S0R0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_342180</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702644.1">
        <property type="nucleotide sequence ID" value="XM_010704342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0R0"/>
    <dbReference type="GeneID" id="22578723"/>
    <dbReference type="KEGG" id="lpan:LPMP_342180"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340027700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_342180"/>
    <dbReference type="eggNOG" id="KOG0585">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14008">
        <property type="entry name" value="STKc_LKB1_CaMKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000206">
        <property type="entry name" value="Serine/threonine-protein kinase Ssp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF77">
        <property type="entry name" value="SERINE THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="241"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="457"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="822"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="901"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="972"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1043"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="457"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="475"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="832"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="848"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="924"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="981"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1051"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIO01844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1132" mass="121613" checksum="3D2E2C268BE5A190" modified="2014-11-26" version="1">MSKTRGKVDDHVKSASPAITKAATSFPNAADTTVAASKMSDSSRDGHNPLIDDLFNDLGQNFSIDDFCGIGYLHGKSISNNDSFASFDPELRRASEESETSSRSSPRTRQFKAAAEIICQVSQHFVHAMRMHELDTFFCPASGENTADALRRQLRTKNQQEVETVVVTLVELLETVRKEGSHVAPLAGALSELDGIGRSRAFSTSMISGMSTASLMRPPVYETNQLDMAYDQQGNRMINCYRVIANLGRGAYGKVKLGIDTNTDQMVAIKMIDKKFLKKKIGGLGANNQEAALKREIAIMKKVRHRNCVSLYEVIDDPDSHMLYLIMEYVPNGPVVRLKPHKLGSTALKSIEAGIPLSGEACNKVLMRCAVRQSATGGSEPLTDAEIASNPTVFFCKPLSQHICALYLRQLVSGLRYMHKRNLVHHDIKPDNILLGTDHQVFLTDFGVSEILSTRQEMKDAVESNHNSKSDDGSSDYSSRSLGSDSTGGDRKGDGGGSKPRLGGGTLLFTAPELFDGSVNQHSLDPHLTDVWALGATLYCMLVGMPPFFGNSYAEVRTNVLTQAYPWCGKTMYETLLATEWRVVLNGLLAKDPTKRWSLTQLKSFLDQESFQDTMRQSAFHEASLGTRSSTCLDGDTFLSSSTAQRTTGLVMPLSDATPVVAPRPSPECLPMANGSNIPFPPHVVPSSARVSALPVEPGGASHSFLRDFSVSEQEVRDATRTVKVEVRRQSIVLSAPARAIVCSYVKSIRAGMQGRSSIQLSCSSPFGSIAYVGSPSSVKMHAGANKISKMSTSSGETEHVTQAPSVAAEVRFRHSSEAGPISATSLFYPPQRSSRISAGTTRTGKQSEGGGGGRALAGGSAEGCVMGRSAQPLDAAFSIVNLQSNAAEYSPTLSRMSSSASSRHSFLAQRAPGGHHAGREANNENGTLTRNSATPSGDTRVLGSGTADTASWFNAKVPSTVAQTMLPESVTPSLIDEGDDRQGVDDDGDSSRFSKFPGCKKTPCGTFLSDDRGFDQVTLTPGSRSAAPPLLNSVLYSATSGVGDSDSGGYRSTSPNPNTVSTPGALLAMPSEKSAFATRSPGWLGLRENRYPIQPLQHRLSEGKLVVPTLTAFEEVLTVARSERRATVNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0Z8</accession>
    <name>A0A088S0Z8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">GCVH</name>
        <name evidence="7" type="ORF">LPMP_344580</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="5">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GcvH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702878.1">
        <property type="nucleotide sequence ID" value="XM_010704576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0Z8"/>
    <dbReference type="GeneID" id="22578963"/>
    <dbReference type="KEGG" id="lpan:LPMP_344580"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340053800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_344580"/>
    <dbReference type="eggNOG" id="KOG3373">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264154at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000066">
        <property type="entry name" value="Glycine cleavage system H protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002270">
        <property type="entry name" value="PRK01202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715:SF3">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="37"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="4">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO02078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="138" mass="15081" checksum="2D5E0E817EFA3CFE" modified="2014-11-26" version="1">MRRAFAAVPVVAVACLRFYGTRHFTDSHEWVEQGEGEVTIGISSYAQENLGDVVYVSLPQVGDTVTAKDVVGEVESVKATSNVYSPVDGTVTAVNEKLKDEPSLVNQSPEEKGWLIKVKCSEIPKGLMDEAAYKKFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S135</accession>
    <name>A0A088S135_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_343050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702731.1">
        <property type="nucleotide sequence ID" value="XM_010704429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S135"/>
    <dbReference type="GeneID" id="22578810"/>
    <dbReference type="KEGG" id="lpan:LPMP_343050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340036900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_343050"/>
    <dbReference type="eggNOG" id="ENOG502RHK9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="48651at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="309"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="386"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="647"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="390"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="419"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="684"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO01931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="696" mass="73600" checksum="BC976EF767B144EF" modified="2014-11-26" version="1">MHTIHDFNKYGLDFLELKALSVPSSLRFLLGIEYDVVLCVNEVGSRRPFRLHFPVFAATFRKLLSLCATRFGLDCEHGETESILTGTAVMPLLRYADYLPGALHVKEILECLQVEPAVKAKKWMGPAASAALPSTLAAYDAVVDSAAAAGVSNEFEASFIDYSEFLSDSSLDDVHGLGFYLLLDYGLSLATHSHLVGISFHKDWDPTEALREFQDFSGWPEFDLRYYDEQRPHDGGVIIMPSSQDACDLLEKYEDEDSDDEGDLLPFILRPVSPLVSVPSLEDAALRKLRDQYWGEVKKHWAHLPHTLNTVVVYNLYDGATLAEVLSFFEPLPIVSSAFVEDKAPSRRRRAFITFADLEATRKALDVDGKNTRGCTLRVQVSPPYISASRRGDPVKPELDGHGAGDSFSKMGSGGAAASRTSHGSCVNASPTSSLSLPTSDNTATALHGKAKPISNGSGGASAATASVAAAHVVAASIPIDKAEPSKTQPIAATLTPAYGAPTGPALSAAHAVVNVSPFSGSVDRAAAVAGAIAARAHAIAAASASPTSPPKAMSGGAAAAAATTETDNRIGVLSSPGGSHMNAAAKEFVPHFQLSANSPEYRPTPPPKIEAMYGDYAGLSGLRDGVGLPPPPPSYVDALTPAPEYRPAPRSSHLSHIGASPSLPAYTLPPPYVLGGGDTNDMLPPPPLPPPYSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S158</accession>
    <name>A0A088S158_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_020060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009371">
        <property type="protein sequence ID" value="AIN95186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698151.1">
        <property type="nucleotide sequence ID" value="XM_010699849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S158"/>
    <dbReference type="GeneID" id="22571816"/>
    <dbReference type="KEGG" id="lpan:LPMP_020060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_020005600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_020060"/>
    <dbReference type="eggNOG" id="ENOG502RZFV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272172at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="353" mass="38373" checksum="BF5ABC04D9B80C4B" modified="2014-11-26" version="1">MSTKTGGMRKPVEEKALLSELSRMFHLLKANRKEQRYGREAATAAAASSAGVCTTGAKASKRATRDVRRGSQRRSRRGGSIWIVLKGGFGPRSVPTAAQAERVDTRANGRALLSERRRAAALKEAEAYIQSAWQQAQEAELLTKDGTPTEEGDAYLAEQYAMASRMLCPPTTGAHLSQLVANHCSSGLDNAVTGATHGQPAYVLTRSEWEDLCTREAAILFRYRTSATPCGTAEDYFKEQQQARENTYHFATAEPTARAGDIVPTKCLVRIRDSQREKHTCIMSTAKSVNYFKSNFGQVLRKELSGSRLPRGSTADEAAAAASANTSRGNHQATLQPGAATSSSSSGKRRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S164</accession>
    <name>A0A088S164_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Endoplasmic reticulum vesicle transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_324040</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERGIC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702085.1">
        <property type="nucleotide sequence ID" value="XM_010703783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S164"/>
    <dbReference type="GeneID" id="22578145"/>
    <dbReference type="KEGG" id="lpan:LPMP_324040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320047700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_324040"/>
    <dbReference type="eggNOG" id="KOG2667">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270930at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF25">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="8">
        <location>
            <begin position="9"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="7">
        <location>
            <begin position="124"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIO01285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="309" mass="34358" checksum="61196F641176FE37" modified="2014-11-26" version="1">MHAARSWQKTDFFRHIPKDLTESTTSGAIISIACVTVMVLLFVGEVISYVSPRIQSDMIILPDLDETSTIKVSMDITFPKMPCAILTLDILDVLHNHMFNSMDHITRTRLDPAGKPISDGISSDLFVSAAEGCRLEGYIKVGKVPGNFHISSHGRQHLLMMHFPNGTNAEHSIHHLSFGTLDVKKLDKKAQLHPLDGKEHRSEVPKIYQYFLDIVPTIYESSFSTAHTYQFTGTSSSSPVPSRQMAAVVFQYQMSPITVRYSSARVSLTHFLTYVCAIIGGVYTVAGLLSRFVHSSAAQFQRRILGKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1G8</accession>
    <name>A0A088S1G8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">inorganic diphosphatase</fullName>
            <ecNumber evidence="3">3.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_030860</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CP009372">
        <property type="protein sequence ID" value="AIN95321.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701029.1">
        <property type="nucleotide sequence ID" value="XM_010702727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1G8"/>
    <dbReference type="GeneID" id="22571952"/>
    <dbReference type="KEGG" id="lpan:LPMP_030860"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_030013300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_030860"/>
    <dbReference type="eggNOG" id="KOG1626">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1608002at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.80.10:FF:000017">
        <property type="entry name" value="Inorganic pyrophosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="INORGANIC PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00387">
        <property type="entry name" value="PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN95321.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="322" mass="35458" checksum="670D5EBF03835271" modified="2026-01-28" version="2">MATAVHTYAPPPPIPSLPLLPLTYDSFIYRPPKTSAQAQAHVLFLLLAAHLTQMLSRSLRLLSSKAAASTAALPVYNTTEDGPADSKVWRLFFKDGLTDAVVSAWHGLPLYPGTAADPRVFTYVAEIPKGTRAKLELSKEEPHNPIKQDIFKSKEGQPLRYFRYGNMPFNYGFLPCTWEDPMHIDPHTKCIGDGDPVDVVHLGPPHRVGTYEPVRILGVLGLIDQGETDWKIIVESASVTAGEGYGTLAKVPQELQATIIDWFENYKVPDGKKKNEFAFSKEIKDAEMALSIVAQCASQYDALMKGKCANPGYWLREATGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1J8</accession>
    <name>A0A088S1J8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron-sulfur cluster assembly protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_331430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702235.1">
        <property type="nucleotide sequence ID" value="XM_010703933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1J8"/>
    <dbReference type="GeneID" id="22578296"/>
    <dbReference type="KEGG" id="lpan:LPMP_331430"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330020100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_331430"/>
    <dbReference type="eggNOG" id="ENOG502S8Z1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275715at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990221">
        <property type="term" value="C:L-cysteine desulfurase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20264">
        <property type="entry name" value="Complex1_LYR_LYRM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045297">
        <property type="entry name" value="Complex1_LYR_LYRM4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051522">
        <property type="entry name" value="ISC_assembly_LYR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13166:SF7">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13166">
        <property type="entry name" value="PROTEIN C6ORF149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="107" mass="12690" checksum="444486645E9149F8" modified="2014-11-26" version="1">MSATAKTLKKSVDRLRGQMMRTAHGFRDYNFRQYFVQHVKDDFDAVAKLPEEEQRKFLATEGRDRLRQLQRMVVVNQMYAKRPVYFDTVAQKHHHRHDDGTGEPVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1V7</accession>
    <name>A0A088S1V7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_332590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702350.1">
        <property type="nucleotide sequence ID" value="XM_010704048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1V7"/>
    <dbReference type="GeneID" id="22578412"/>
    <dbReference type="KEGG" id="lpan:LPMP_332590"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330033800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_332590"/>
    <dbReference type="eggNOG" id="ENOG502SDG9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="243242at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="587" mass="63229" checksum="A52548398A5038FE" modified="2014-11-26" version="1">MPTEEKATVSPTNRFATQHPSDDVSSWLRRPYTRTISKEIRTTLQLQRSFEDIREQWRDLCETYTHARVESSSCRIRQAGEAVLPHGTRGVVDRLMSQLKSVKQELLAHLSRLSGALAVLSVSLPTETSAPPLPAWVSDLMECSDPLNARTVRVAENSEAMQSYLQAIWLARRVWVWSLCFASVTMDLELLSGSVSVAAELFFGNAFATAIVIAPERNGVDHVKSDGLLLHSTYNIGGAISERLLYATVAAAASASSESGTGNAISCFDDIDSPPHILAKLDDEACEVAAFFGCSASWAKCAGDPVGGAYSMHVGPDTVAVACDDPTPLSKTCGAAPVRDIFWVQAAALCYSAIVCDDAATTRLLAVFEAAKDSFPVEEAERFAQGDFAAPLTAAKVPDQANPPRQPPALQSATVVVLLAAKLLVDEDFNALQQLLRRAGFDGGDDSRPANDEQDCSRSSLATLCPQGVLLGFLIRLLVEHVVRRRWTEHRLGQAFRPTEPLDIGAGDAAAGSGETKTSTRYRLACALANGVSRLATMEPDHLDDLTTTPTLFHGTKHLCNALQMSTLHNMGGDWPLPPALLRGVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1X5</accession>
    <name>A0A088S1X5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal recognition particle receptor subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_332740</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SRP receptor beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702365.1">
        <property type="nucleotide sequence ID" value="XM_010704063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1X5"/>
    <dbReference type="GeneID" id="22578427"/>
    <dbReference type="KEGG" id="lpan:LPMP_332740"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330035300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_332740"/>
    <dbReference type="eggNOG" id="KOG0090">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="41266at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019009">
        <property type="entry name" value="SRP_receptor_beta_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09439">
        <property type="entry name" value="SRPRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="387"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIO01565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="495" mass="53320" checksum="459DC1FE48DC7B30" modified="2014-11-26" version="1">MSALHTVVNETIIEAVRVALESYIAEGQQLTVPNDGTRMPAEQESIIRKALFAGLQNLRAAVQQHATRLTPPGNTEEVDSHTHMHLASELTTTTPWGLSTALAQLASNATATQEFVQQAVLSIWAHLRSAASRREGSIAANAVYTATPDVTRVLEAAAAAQHIVAADGVAPASTVWPMTPGSMVAYLSTFSAAEWVWLLATLVLGYLILSFVFGRILGFNGLLNRRRPRTTTVLIGLPYSGKTALFVQLVHHRQLLETRASMRPNSGYMCAAAQHGRSTGTAGVKVVDCPGHPRLHKEMLRAVSEALNVVVVIDSVTVQDNQREGADALAELLINVLQSPEFYGVRRLLFACTKRDEVISYAPKAVRRLLEAAMVASIESRQNAMGRVESVRDSNNTVVTSKGRPDGGRQKGGGGRRHMLFLDGADNDDRIGEAVPGYEHLRGAAGGSEKSFNFEQLGIPVAFVDVSSRPNAAEHKYSITVLEDFLLGGGFGRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1X6</accession>
    <name>A0A088S1X6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dihydrouridine synthase domain protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_350470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702986.1">
        <property type="nucleotide sequence ID" value="XM_010704684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1X6"/>
    <dbReference type="GeneID" id="22579076"/>
    <dbReference type="KEGG" id="lpan:LPMP_350470"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350010000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_350470"/>
    <dbReference type="eggNOG" id="KOG2334">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262250at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052582">
        <property type="entry name" value="tRNA-DUS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="6">
        <location>
            <begin position="105"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO02186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="440" mass="48086" checksum="33BCB756A2D47585" modified="2014-11-26" version="1">MRVEESMFYQKAILAPMVRVCSPGFRALCGAHGADVVFTEEVVAAKLATCRREVVHYPTVDTPMAEYVSYDAFKNTYKRSVVLSIPMRGATTYAGPKAECITSPRIVLQLGVADAELGAAAALVCSDDIDGIDVNMGCPKKFSVQNGFGAALMKRPEVGGAIVQAVHDAVNSNASVEARGGRRVAVSLKTRLKETTEDTVEMLRGMLTAAHHTPTSPVLHAITVHARTPNQRSEQAPLYSRAAEVVRTCRSDTAFEGICFVLNGSILSRQDGEAKCALYGFDGAMIARAALEDARCFHREGRELPTSSAADEGEAQLAEDAKEYAMSIMKELFFYSVRYRTLFHNFKYHLTRAFPVVKVLKPLMKVVQLDLRSYADCYEFFRLSVEERALIDSCAQTMELFAAKSVPVLKRAATPPAASDEYGELAHKLARVEGMAKAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S228</accession>
    <name>A0A088S228_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_333150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702405.1">
        <property type="nucleotide sequence ID" value="XM_010704103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S228"/>
    <dbReference type="GeneID" id="22578468"/>
    <dbReference type="KEGG" id="lpan:LPMP_333150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330039600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_333150"/>
    <dbReference type="eggNOG" id="ENOG502SKUM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264767at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="778"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="951"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="647"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="784"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="987" mass="106119" checksum="C665C63ADFA94AC8" modified="2014-11-26" version="1">MSAYYQMHSSPGHRLKHAATPIGVTPSHEEDEVRGHRNTPELQPEEPPTRPAEKCVDMPTRVDDALRLGYTTTSPIARHAVKEVPTSTRGVVPIQGCMAVSTSDSIGNTVVFHPPDRAVARMVSELLSVSEHKSLSRCASSVKIGTDTVNMTLVEEDDDDDDAEDRNTENDKADDNVDGDVVMFELYKPTEMRRPENAFSGGSPLPSVVLRMRFPTGGASERRCSGSNGSREQASGRYLTLSQSSRLEDAHRLASRGGEICKSSNSSIDSFSVEGAGTAFQCSGQPQRMESSMNSQLFHKSTRLRNAMNAPLVRGGSRYDSVRSPCESTQVSADVAAPTVMNFSGPHLLSSDQMALFSHSRGHNRHKHANHLQLRQNRCHCDGSVEADGTRQLDGIVLGMASVDPLTGDGEAAMASSLSPTDGFELVRAPITGLRAMVLGNDAVEEEEAAEDPEMRELQSEQLKRFCSKVVRQHRDGAERDVSAHGNLPPTSTTSVISTLQTQQALCMDAIAADSVALGHEVGVPPFLQSPALRDDGQAAQILESVLANKLKKRGKKVMFSMNGMEPHDTEGGGAAHLPHRSNPQSTCVRLHREPSPLALQCGVARRTPSSDQAEVPNSVDEAVPVLLLQAPLGRGAPSLSVTNTPRRADKDDDHPLTPLLPSPKSATLMQQQQQPASAEMLATIPLHPVPPSATLAQLSVFMAEDPRKRLSSVGKMSEISKRSCIATVARLEGTGDAIGLRQSSNFLSCHTRSYDSHLAPPNVLSSVEVCLPVQYSSKKGRTQQHPAQRSTGSASPVHRIEQGGRATSAFMSPSLHTAQVVPEQDLASAPTQPAWTTTLTLTTAAAGLATAKRNERKEKAYKKSRRDATHKSTLSFPIVKSHVVEKVVPQLPTTPSIRSPCAESPREWASAKPSLSSFSGDEVSLMLPPALERRFFTSHGSAATMVEAGAVVGSARASCKRRKSDAMKSRSSMVGDPAVPSSRKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2E8</accession>
    <name>A0A088S2E8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside triphosphate hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_352970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703234.1">
        <property type="nucleotide sequence ID" value="XM_010704932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2E8"/>
    <dbReference type="GeneID" id="22579326"/>
    <dbReference type="KEGG" id="lpan:LPMP_352970"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350037100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_352970"/>
    <dbReference type="eggNOG" id="ENOG502S4YC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272016at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="854" mass="91858" checksum="7116A26EBE320961" modified="2014-11-26" version="1">MCTSSRATSQCVATCIQWLDYASATLNPDRLPEHMVHLDEMLTLMRNTPPPSTLVDEWSTQVWSMAEEPYPVYLLRCLAHQSGLTQLSPHFAVPITDISSNDEAAVAVAAGASTGHSPRLFWERCMVVGVRMEPTTKNLLQTGWETQPCPNCAVRDRAATNVHGDLNRQAQLSVLPLLYGGTQCGECGHTLPLVPTWTRVLYLVLQRRDRSRAAAVAYGEEVHDHLWLGASIDTLLYTSTTEQQQPLLVVHAAAVQAVAAQPAMLPCTETAKDAFHLLCQEESVSRLALKWGDGAAFTAAADLHDVARRIAPQLQGQMHVKGLLFLVVLHLVYYANHPAAVGLHRHPLHVLLVGPAKTGKSALLREVAQLIGYEAEVLGSTVVRTGGSTAAAGDSAFSAALPMRRSAVLVAGPGMTATTLVLDQIPSTAAGAAATAPLLEVMERGQGCSAAGSGGGSIAAGVPDVYPLSSTIIAAAGEESAAAVQLAPYFSLIAAVTPTSSLDDTAIISQDVVAASRARSSHSRETSRSTSRPTQLSSSPRHSQRGPSAPQRTPHRTEPSVLSERLTNDDVWYLVRRAAEPALLNNVVSYEACYNTFIDRLVDCAGLLEEAQPSVCRDLPPPSACRGQHHSGHPSVTCNSLRATPLTLEEHLRVLRALSRARAMLEPVERLREAGWTAQMGNEVWTLYHRHLVACADLMQHRSCGSGVMASCVPAAAPHMAPWMLSSFATRGGSIAAAAGYPSPSRLSRDAAALKGEGEGVMWAIPSRGGRNLWRSQKAPSKKRCRLMFVEELRQRQRQRLSGQVESTVPPSEVEHLFELLGGNSAFGDPLDVVMSQMQEEGLLLRRPGGWRSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2I1</accession>
    <name>A0A088S2I1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosome assembly factor mrt4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_354770</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Ribosomal protein P0 is the functional equivalent of E.coli protein L10.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Associates with the pre-60S ribosomal particle.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">P0 forms a pentameric complex by interaction with dimers of P1 and P2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
            <location evidence="8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703408.1">
        <property type="nucleotide sequence ID" value="XM_010705106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2I1"/>
    <dbReference type="GeneID" id="22579505"/>
    <dbReference type="KEGG" id="lpan:LPMP_354770"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350055900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_354770"/>
    <dbReference type="eggNOG" id="KOG0816">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262308at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05796">
        <property type="entry name" value="Ribosomal_P0_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1730:FF:000005">
        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000006">
        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033867">
        <property type="entry name" value="Mrt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051742">
        <property type="entry name" value="Ribosome_Assembly_uL10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841:SF1">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 MRTO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="8" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="9">
        <location>
            <begin position="126"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIO02608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="227" mass="25437" checksum="83B7893CF75FB919" modified="2014-11-26" version="1">MPKSKRAKIVSLTKTQAKTRADKDKLIERIRQALEDYTDVYTFQLHNIRTNILQLIREERAEDSRIFLGNNKLMMIAIGRDEKSAQKENLHKLSPFLTGLCGLFFTNLSKKKVKEYFATVGAPVYARTGQTATESLVLKAGPLPQFPHSMFDHLAKLGLPIKLDRGVIVLLQDTTVCEPGDTLSAEAAQLLKLFGVECAEFKIDLTAHWTNGVAKKVIHSASSKRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2J0</accession>
    <name>A0A088S2J0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_353040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703241.1">
        <property type="nucleotide sequence ID" value="XM_010704939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2J0"/>
    <dbReference type="GeneID" id="22579333"/>
    <dbReference type="KEGG" id="lpan:LPMP_353040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350037900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_353040"/>
    <dbReference type="eggNOG" id="ENOG502SKKB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="257896at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="19419" checksum="DEF51DFC6E67CA17" modified="2014-11-26" version="1">MWGLSITRVFQAYCAGAVLFEIPTIVMLLRGDILLPNAGAWVDDKYYYTNNKSLMYVFVAILACLIVSRGMACALPKSRIIIAYLVTVHTFEAGLYLYCCKHKEEAPNRTVYVFGTLMLVNICLFGARLVQLKAQQTRAEVAGLEWRQEQLAIIRKKRADYAKNRGEKKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S340</accession>
    <name>A0A088S340_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_080830</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="AIN95891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704213.1">
        <property type="nucleotide sequence ID" value="XM_010705911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S340"/>
    <dbReference type="GeneID" id="22572545"/>
    <dbReference type="KEGG" id="lpan:LPMP_080830"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_080011000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_080830"/>
    <dbReference type="eggNOG" id="KOG4619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="430821at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019537">
        <property type="entry name" value="TMEM65"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21706">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21706:SF15">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10507">
        <property type="entry name" value="TMEM65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="331"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="63"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="251"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="407"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="421"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN95891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="737" mass="75110" checksum="2D8E9063E54ED83A" modified="2014-11-26" version="1">MAPSSASLAEMTGRLREALRTLSEVEKAKVEQAMRVTAATAISSQSSSVNVGEGRVALSTAASMHHPSAAVPPGALSATSTEEPTASDSSCPSSSKSGGDVSGAATANAPSMGGRSSTTTSEAVAMPLSTSSSWIRNKKPKFWALVNEAGTDEVEGGDNGEGFATAFTAAGSAVAAPSGTAASRSTSATASAPLTATAPTLTGGAAAPAKELSQLPALAEPLQTASDVATASSPPSRVAASTFLSATVDGRTDGVSSSSLKATGGAVTAHSVRTSTSVSPFRNRYKRDVAHVLSELLSNDPALGPQLLSQLSAESRRLLLIMGAASEYFGVDYEEVAEQVKEADTDRDNSISSKEYDAWVRRMADSTPAKRRHAKEGQAMEGALAPVLSLDCASAQGAAVAVAPLPLSSTASPSSSRDATETNPSVKGAASTSTTAHPPVAVSAPLSRQTADMATDTAKAARACIIGVMQKSASSAAEVPASHDAVADRLAASVAMPSSTSASLENSTAGSSCGRISDVTGGGAVASPFLPTTSAATVTSAARASVKQDPSYIPWSTYLRIVVTAAPPFLAFGMLDNSTLVLAGGAIDNALSGSLGLSQMAAASLGGVVSGVAGIQVHGLAERYTRASPPRLAPEQQRGVSYSRATQAGNMLGMVVGLILGMTPLLFMSGSTQLAEQEERDRNRFRQEAGRSHQRQCKAVEKKEIALRQQLWEEEKATREALLRDKDNLPLLSSVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S349</accession>
    <name>A0A088S349_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="3">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_080930</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="3"/>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="AIN95901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704223.1">
        <property type="nucleotide sequence ID" value="XM_010705921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S349"/>
    <dbReference type="GeneID" id="22572555"/>
    <dbReference type="KEGG" id="lpan:LPMP_080930"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_080012300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_080930"/>
    <dbReference type="eggNOG" id="KOG1448">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000002">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000014">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002320">
        <property type="entry name" value="PRK01259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF32">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="12">
        <location>
            <begin position="48"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIN95901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="371" mass="40591" checksum="267E78060F5BAF4E" modified="2014-11-26" version="1">MSSSPLRDQLKRIEKAYFYQPGKMTEVHSVSGTVSPHTEKRDHSRPFCLVSGNGNRPLAEAVALLMGTHTHHTSVTQYSNGEVNVRINESVLGADVYIIQSTVGNEIIDVNTALMELLLLTRKMRLSNAKSVTVIAPFFGYARQDRKTNLRGPISASAVARMIVKMGADRVASLDLHSNQIQGFFDNIPVDNLLMAHEFARYLRDQPWFDVDQMVVVSPDAGGVERAKQLADILQVGRIVTIVKRRIAAGKVDTMQSVGEVAGFTCIIVDDMVDTGGTLVKACELLKDLGAVRVTACCVHGILTDPCSERINNCSALQELVVSDSIPQEEHQKAIPKLKVLTIAPLIAAVIHQYMNEESVSSLFSPSLRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3H7</accession>
    <name>A0A088S3H7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoprotein lepp12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LEPP12</name>
        <name evidence="2" type="ORF">LPMP_355860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703516.1">
        <property type="nucleotide sequence ID" value="XM_010705214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3H7"/>
    <dbReference type="GeneID" id="22579614"/>
    <dbReference type="KEGG" id="lpan:LPMP_355860"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350067100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_355860"/>
    <dbReference type="eggNOG" id="ENOG502S5S0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="260185at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="88" mass="10215" checksum="A06729E3DE4B5289" modified="2014-11-26" version="1">MGKRTKKSPKQKRKLAMADRPRKLTSKGKIQHKRGDLKMMSSRNVSFSVRQGKGGKWVKTGERKCNIHIVCDCVKRTDPARMRYITNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3I2</accession>
    <name>A0A088S3I2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_356710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703599.1">
        <property type="nucleotide sequence ID" value="XM_010705297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3I2"/>
    <dbReference type="GeneID" id="22579699"/>
    <dbReference type="KEGG" id="lpan:LPMP_356710"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350076700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_356710"/>
    <dbReference type="eggNOG" id="ENOG502RXES">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272111at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="590" mass="64010" checksum="ED82662B0EB1AC52" modified="2014-11-26" version="1">MTAMLCASCQHSFPEDMLAPASFSTRVGRYLSRTTSLLCKTRGKTSEDDHRLSQLVQLLQQLCGVMQEEVQMLHERQNDLPVAPFSSSTTRAGQSEQQSKNRRAAPPAVSFTSTGDRYRRSPSMELCGTSDEAARLPFMGMPSSSFAVVPTASSRVMFEGSVPSYQLKRMITALDLVSATLYNVLESLAVQCRASVALLWLRPRQNLSSSELVAPFVVGRDLSSLANSAPYRTLEFSIPCVACQTGVALNLKPQPHVQNAASSSVADLTLTELMEHTNAAQLLMPVHDRYTERHATTRGSTVNTPAVIAVIQLIGSAINPVPFHRRNEEAAAQTATLLSFTISSYYETMIAEWSNRFYVPTTLHATGKYAAGLDLRAAEKVLDDFATPPLLMFRSAVGNLSELTSANEARDALKLLGQNALRRSASLRPMATVKDLFQHATTMETNWVSAVQRTTRLEKTVAALKDDMLRRDVSALQKAQEAPKSRGTSAGSRPWSSAEKRNAMPLPSVAVVAPAAKKRSSLSSADINIPLTPPVPYVAEAVKIAAAGSPSAAVSVPPNTEVLKADEVDVLEAVTLRRLRELGVDTSMFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3N6</accession>
    <name>A0A088S3N6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta-hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_100320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696754.1">
        <property type="nucleotide sequence ID" value="XM_010698452.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22572768"/>
    <dbReference type="KEGG" id="lpan:LPMP_100320"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100008400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_100320"/>
    <dbReference type="eggNOG" id="ENOG502S98N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5954035at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037">
        <property type="entry name" value="FORMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037:SF24">
        <property type="entry name" value="POLYCOMB PROTEIN PCL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="162"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="717"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="837"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="905"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1178"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1278"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1398"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1498"/>
            <end position="1525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1550"/>
            <end position="1645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1790"/>
            <end position="1847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="747"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="768"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1198"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1218"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1511"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1562"/>
            <end position="1576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1829"/>
            <end position="1845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN96101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1938" mass="205897" checksum="C9543871AA205C9C" modified="2014-11-26" version="1">MSISSSVTYALLCVYYACRTVLLFMVETVLFLPTYYLVERHDTPSAWLGRRGEAQVQPVLSTAYQYQKAEEWDASIYSNTADIVTVGARATPLESSTREMEDSRCILSRKAVSRIRSLHTANECTSRWCPQVPRTANPSSVTYPTGTPQQRPQQQRWQLFPRLYSHPPPGIPQSRYDGGDGDDDMNDSAGSCSSYTLANTPLAATLQPPLSMAIAEASGWHDCSSGGEMVPISLLSSPMQRSQFPRGKRHYSGVLDEEDTAYASFNGRLGSLVRDVVDGEYQQPYVTNAFFDGLAVKVLPSAQQQEQQHLSAALRKRVDNTEADLSARWGHRQSRAASRRAAARTASTSISAATARERLCAMVPGWCTVVFHSPTQRSATRGSPVEEASSTFRGQYGFLPPWYAVHARAQLLLALADPLLRIAAELLCCRGWGMRTLSSVAPSERISELSSLATWWDAGAFLLRPLLLCFRALRCLFYATVGRLDAAVSPHYSTRRSASPTSLNAAATSSGVHPFYRLEGAVQTRIDRYIADTHRTFEPLHTHAAATTTVPSMSVTTHAGSSITPADHGLSQSTTVSAKAVGAAQTPTQGATLPPPLSSISTSAPVCRQSVGVYWLHGRRPPTWTAASAEDLSTMSTPQPPSPAPVVVLLLCPSLLQGNGLCQHTVTRLSHLCQLLTLAGVWQDSFATDDAAAPNGEAEADRAGLPTLRGTAITKMTQAHDESTDSADALQSSAPGTEKKPGNLVLSTTNSSYSGSSDSSGAEVNHQPPLQVTLSSPPLATRPVTRPAAQWYAAVPVVELRVSATSPERADDVSMPPLTLKDLRHIVERLRGNLESCLPPPTKYSKTPASTKAGRATRRDLFDPSPAEGAAPKVQATTHNPRRAVYIVAVGWSEAASPLLELAITQQQQQHQQQSSTNSGGSTEDENEDSCGAQTPARLDGVVCISHTLSSAFQLLPQQHAEAMALKQHSQTRPLPARAAWRASHQSASTVGSSSTLSAIAGPASSASSVTARLHAAPHMPRILSSLTTGPARLLVMLTRMQLIADALLAHRQHQEQWQGGGMAVVGNGAIPGSVGARHCAEAHADTPPSQAGPASAPALSLYRILHIFREVREEVNRAQRGLDRATIVWTHQQQHLQARLAQRSAGLARIPFPSAGNFSALTSRIMDNDIDSRVTRAASEGQHSLPMHRQPPPLPPSSTSAGASSPSAPTATPQPQHTLSPTPFSKFGRTTSPLVSLASIALAASSSDVAAGTASEGSTARGGIRYDAVGNANVLTPPAFSSTGGGGSVPSLLSVDQDTPQTHDEQHSLSRHHHFSHTLPLIMRQDFSQEPSVLWGLPRLETVTDWEELAKSPIMAEVQQQQRLEAANTTANDLLPPPSVDPPTLLSCGAMRVTPTSAIGSGAGGGGRRRFLSKPEVGREAERPAASGSLVTPSSFSDNPLRCACSYMSTEDVIASCTLQVVSPTARQAARLPVSAAAGAAPTAATDEERSVLVGVPSMGSSMSHTAVRNHHDSADREHAAPSLAQGKAVIEASYNLEATLPPSADTLAAQSTAAKAPSPSVRTATSHGGNTSSLGMGGTEGKRGNTASSSAGPSSREGVLHAPTRSARSLVSHYGPPCNSPPPQQPQQQQQQQPIPYPPPSRALALSSQAAALVELRVRSAQHAALIQRIRVPTLLVHARDDPVAPTSSLPFSLLQANPWITTVLTRRGSHAVFMESASDVWRRPRLVVTERLCPADTTLPASATGMMEDMVYWPSGGLINLGRVPGPRGLPSWDPLSASAASQWGAASLPSAATRSPQPPAPMPAARLQGPPPFPEDAKTKHLRGSGTSSSSTSISNSCSTDDFADDDDTGAGALVEWLPVKDVNAGVQQQQSNKRQCTAPPSRSHQQQRVAAAAVSQWQVRIEGTTWLERCICEYVEKVVLCPPAPPLSPPPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3U9</accession>
    <name>A0A088S3U9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Intraflagellar transport protein 122 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_351030</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703040.1">
        <property type="nucleotide sequence ID" value="XM_010704738.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22579132"/>
    <dbReference type="KEGG" id="lpan:LPMP_351030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350015900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_351030"/>
    <dbReference type="eggNOG" id="KOG1538">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10255582at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056153">
        <property type="entry name" value="Beta-prop_IFT122_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056152">
        <property type="entry name" value="Beta-prop_IFT122_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039857">
        <property type="entry name" value="Ift122/121"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057411">
        <property type="entry name" value="TPR_IFT122"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12764:SF4">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 122 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12764">
        <property type="entry name" value="WD REPEAT DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23381">
        <property type="entry name" value="Beta-prop_IFT122_1st"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23377">
        <property type="entry name" value="Beta-prop_IFT122_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25295">
        <property type="entry name" value="TPR_IFT122"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="IFT122 first beta-propeller" evidence="10">
        <location>
            <begin position="20"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="55"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="IFT122 first beta-propeller" evidence="10">
        <location>
            <begin position="192"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="IFT122 second beta-propeller" evidence="9">
        <location>
            <begin position="299"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Intraflagellar transport protein 122 homolog TPR" evidence="11">
        <location>
            <begin position="672"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1105"/>
            <end position="1131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIO02240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1298" mass="145365" checksum="DE56E29285E0386A" modified="2014-11-26" version="1">MRTSVRWSETAEAVKDVRPPINSLCYSPSGDYVVASCGVRVLVYAASTGTLLHSLKGHQNTIYCVDYAADGKHFASGGADRTVIVWSSKGVGVVKYQHRESIQALAHNPISSHLASVSSIDWGLWSAEQPKVSKYPLPSKGLCAAWTPNGKTLAIGLLSGTIVLLDKGVDEKARIQRSAPVWTLAFTPLREKGVDVLAVGSWDQRLSFYGLSGTPVGRERELDFDPCSLSYFNDGEYILLSGSNHKVTLFTKDGNRLIDVADADDWIWSAHQRPRQKQLCCGTNDGTISCIDIAITTVHAIYNDQYVFRKDMTNVVVHQLSLDRNMVIPCNEYIQKVATFRNRLAVQLQERIIVFELFYDDERNMRYQDIAQIRRRLECSLLCLTTKAIIVSKERRITMYDFQGNKRREWSMESAVQFVKVAGGMEGREILLVGLMGGQVMKVFVDNPFPTLLHKCNAPIKSADFSSSRSRLAVIDSTNTLHVLGLGQKNELLFSEDNVTAVAFNIDVEDILAFTTGDNTLHIKTGSLPAYQQAVRGLVVGFKANHVFNLHYSNMMVIDVPHAHALYKYVEMRNLDRAYDVACLGVADCDWKMLGLHAMSHARLDIARKAFTHIQDVKLVELLKLLELRCRQSRVEDGLPPTVNGGSGSATTAAVAATTDKGLVSSKDESAAARAAAKDTILYGNILAFQGKYHDAARQFMKAGSELKAVEMYCDLKMWDDARKICTDEKLLKDLIRQQARWAEDSQNFVEAASLYESCGDYAKAIGMMGQAGQVDKLMKMCRSLPKSEVTLITECGNFFRLHNAIPFAIEAYEKVQDHRALIQVYVASGDWRNAFTILEKAPSLAREVYVPWASWLADNDKFDEALEAFRAAKWPKEAMRLMETLATNSVTCRKFRDAAFYYVHLAEEYGRFDDDETPSDVMKAARIRRSNECIRRADIYYAFSSVYAHTTQPLPYNELSLFHAAKYLFGMCAEAPIPMNVGKTAILYTLSRIANRLEMVRTARAVFEKLQGVILPVSMMEQVDVETLIVRSKPVKDREELLDRCFRCNQLITQLPMAGDRCPTCFHQCVRSFVNFECLPLVEFVLADDVTDEEAEQIIVSGVGRRRSADDEHNNSQSDAVDAKSLPKAKEWQSDKGANVISFEDENIDYEIDQQLVAMGRSKAAVNKGNDPFFTQLQYVLRPGRTTAVYQPFIASADILKGFRRDEVFIVRPRYGTLPVPNRYYRLLRSDIQVCLCNGCQHFFIAGDYEAECMKGNGCPLCRYSPGKQVGRSMRQILFDMEAAATVATTTSTAGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S4H8</accession>
    <name>A0A088S4H8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_354000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703335.1">
        <property type="nucleotide sequence ID" value="XM_010705033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S4H8"/>
    <dbReference type="GeneID" id="22579428"/>
    <dbReference type="KEGG" id="lpan:LPMP_354000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350048000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_354000"/>
    <dbReference type="eggNOG" id="ENOG502SKJI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273299at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO02535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="271" mass="29386" checksum="BD497A740463712E" modified="2014-11-26" version="1">MLGEDLDIGFYAEDAYAAYVTDLAAALHLLPHCRNARGATLEVVFTGPFMAFSAYQEAVKQGKLVPYTELPWPISEERDVQGVAGASLAVVLHGWIEKLNAARKVQLMEPLFPAAELGETIVARSAVDKVDNSAQCAFASTLPPCAAVSADKNGTPPTLKMSRYRIVGNLDFLLHLSSSNRPMGESQVTVDSLSVDDCDLEKADYPHDVDGTTRAAHACRDALEQRDDVSLARNAVNTVIKFAQMAEEHPGEVASVFVDAQERVEYIQFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S4M6</accession>
    <name>A0A088S4M6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PSP1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_354680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703400.1">
        <property type="nucleotide sequence ID" value="XM_010705098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S4M6"/>
    <dbReference type="GeneID" id="22579496"/>
    <dbReference type="KEGG" id="lpan:LPMP_354680"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350055100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_354680"/>
    <dbReference type="eggNOG" id="KOG4679">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="243127at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047767">
        <property type="entry name" value="PSP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041131">
        <property type="entry name" value="RicT_YaaT_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830:SF21">
        <property type="entry name" value="PSP1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="1">
        <location>
            <begin position="496"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="584" mass="62907" checksum="C7A3184C4FC76E16" modified="2014-11-26" version="1">MPTQASSQTMDREQLASVMRKLVTDADDFFAQQQKTLQLSYAELNSRIEQLRMHVQQQQLQLNPMHSANGGYSNVNPSLFPTVHSFPNADVLGMPVSKAGMIGGVTTTPHAANAMNATPLRSNTGAAVRSMISGLNGPNGALGVSEAMPENARSNGSLGGYLSSALNGSTVAAAGPGSLRSYMADTVTSPKKQLALSQPTNKSSSMLPPHMAGGLSAISTTDDSINGEFFSTAPTNNNLSHNNSLMASPQAVQKLSLVELIERFNMSSAPANTTNSSSFNFDSLYEQLTGGCGPEDLPQSPINYTDSAPNLFPTSQTGNAQMFPCDLHHDNGGDQLPDANGLGGGVMAKNSIPIDTLRALHDQHLTTSMRVAYERGRPKVLKIPGGAADTPGKLGIDPHSNCEVLVEFKRKRVLQYESHEYVAPGSYVIVGGDRGEDLGLVVYVWCEVAQEGSGHVHAVSGADTLDRSVADIRKRKVIGVGLTDSILPRSMGVGNGTVLRLASETDVQQLIGTQAELERRAIDVCAQLVLDHSLPMVIIDAEYQFDKKKLTFFYEAQQRMDFRELVRHLYKTFRARIWMELVDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S4P5</accession>
    <name>A0A088S4P5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_130420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697124.1">
        <property type="nucleotide sequence ID" value="XM_010698822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S4P5"/>
    <dbReference type="GeneID" id="22573152"/>
    <dbReference type="KEGG" id="lpan:LPMP_130420"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130008300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_130420"/>
    <dbReference type="eggNOG" id="ENOG502S1XH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266844at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="698"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="768"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="836"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="331"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="712"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="783"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="845"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="986" mass="108586" checksum="EFF03C9077F287A3" modified="2014-11-26" version="1">MELERLEERVEDHQVKEETELLALETSVLVKTTELEEKEQELASRRAELKAYTTERLETLTSRYAEEMAAQAAEVRSLDGARFEKQLQQVCDMGLAADQAVRELREQAALVLEMQPYSEAGVRLALFSHVTNAVVPATGDASSSSSTAGAAPDAVGSPSAELSTTQLESTLRQAVMVLRGYCDKRLRHARDSLVDYLHTSTLDAAHSVRRGREQAWMQDAELHKQFFNRYMVDMMQRYMTFYKERALLKQDNVAALQADVRRMAAELRSHTAERLQQLLRDVTAKMTLSTQHHTQAAEEACALLRKKAHTVVEGDMAMDDAQHRELESRLLAEADARRRRHHAEVESLTEQLQRLRRSGEAVNRNSFQALRDAAAATSSQHAQPLREEVLALKARLVERLRGGASGMASAFSVARMHAEELAHVLRSAVADEAARQQAASLLRQQCDELRRGLTTSLCTEVVERLQQTRCVQHAHQARIDALAKTWEAAHRQNLAAACSLILPVSSSTPGTADGQYVSDTYAAPQDVVSTALLDVLQNRLRARDDTRRSLLTSRRQCTSAYLRKLEEMRDEQAALQDRCAALWSAGQTQVAQQRITQEVEVEVEKGLITVAAEQRVVDRDRHAVERKCRRTAEMTSRLRHEAPQHLLCGSFPPPLQEVVTTHPARTQPLTTVDINAMPKPSNSTNTFTTVHASNNATTMTKKNSAEAPPSPSSFSPSPASEAFQAKRRVEVAAPGQKMCRTPSTAEASHDTDTQPWSSALLRAEQRLPQAGTREGSDVLSTAQGSQQGPPQSDSAPIAHHGVHNEGAAKVLASSKGAQEVDSTRVYCRLTDTTVEAEGATSTRGVDPRDFRSPRDTADEKQRIGSSSLDASLPPVSSMWAADSDTDPVPRTYAMTSPAALPAQRQWQQRLHAHHPPRDLTLSQTTWSTLEEYLSSSADAPNRAVTNRDVEDTSTANFIATGSLDDLSNFIALLSCANSPASSSVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S595</accession>
    <name>A0A088S595_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PSP1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_357230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703650.1">
        <property type="nucleotide sequence ID" value="XM_010705348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S595"/>
    <dbReference type="GeneID" id="22579751"/>
    <dbReference type="KEGG" id="lpan:LPMP_357230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350082100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_357230"/>
    <dbReference type="eggNOG" id="KOG4679">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="243127at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047767">
        <property type="entry name" value="PSP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041131">
        <property type="entry name" value="RicT_YaaT_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830:SF5">
        <property type="entry name" value="PSP1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="1">
        <location>
            <begin position="151"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="241" mass="27011" checksum="5984639E9F691BA6" modified="2014-11-26" version="1">MLATLTDITNVQATVLPPQKVKIVALNVAPAVQTVAKPTVAQHNPYKWKCLPAGTHSAADAMADQEAAYAMPVQELFQEKEDRAPPAPCGPLVCNTLVQFKCHQAEFLSSMVVDKGQYVVVQGDRGIDIGVVIRINTTSQKTYVECTGPVGSILRHATQREVDYWATDLKDAEAIAAAFCQAKVRSHGLPMEIAYAEYQFDKKKLTFYYEARTRIDFVQLLKELYREYGCRIWMEKLRSHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S8R3</accession>
    <name>A0A088S8R3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_205240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN98016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698723.1">
        <property type="nucleotide sequence ID" value="XM_010700421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S8R3"/>
    <dbReference type="GeneID" id="22574736"/>
    <dbReference type="KEGG" id="lpan:LPMP_205240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200059100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_205240"/>
    <dbReference type="eggNOG" id="ENOG502SPFP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267978at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="267" mass="30099" checksum="7F048AB2CAC1CEB0" modified="2014-11-26" version="1">MPVRSRFMNPLDFLSSSEPLMLTPEEKAEEMAEKARVAELKNDAKALAAALAQELAERKAKTTPAVVTKPRRPAVQAPSRPRRYGTQQQHLPSLPPRSPKLAPVTHRPPRRHKASAKSERARVKTLKRWRKPKPPHRPQTPAAQRAFSIPRERSRSPKMPASTQRSRRKTHQTPQRQSGRQPMRRTAAARIRAAAAAASSRSATSHKPRASRSGKKHPAVRPHRAMKVYASVVMRPRSKSTVKTWRLAKSKKRAVVKARCGKRQKAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SC69</accession>
    <name>A0A088SC69_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_261740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699993.1">
        <property type="nucleotide sequence ID" value="XM_010701691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SC69"/>
    <dbReference type="GeneID" id="22576077"/>
    <dbReference type="KEGG" id="lpan:LPMP_261740"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230028100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_261740"/>
    <dbReference type="eggNOG" id="ENOG502SI4W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="263483at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="211" mass="23628" checksum="159F4C60DBC37146" modified="2014-11-26" version="1">MKSTPTSASLPVAQSRSSDTRDVLQEALTNFVTDSMYDRPQIILEYMTSWARKQLLQQEGRGAAVAVTRKVSRLSITPTTGDAVTQAVAFCETSNEADPVEEAEAANRLRKLAEHRQKQYGDIAQGCLDQYLISLEDSDGDVFYISQLRRKMDESRLQARSARTDTAVVAAQLKAIEEGEGSMTDKVLEQAALLYEYEQRWAHEKPKRNHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SDD1</accession>
    <name>A0A088SDD1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_281080</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700448.1">
        <property type="nucleotide sequence ID" value="XM_010702146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SDD1"/>
    <dbReference type="GeneID" id="22576553"/>
    <dbReference type="KEGG" id="lpan:LPMP_281080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280016800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_281080"/>
    <dbReference type="eggNOG" id="KOG0900">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10248551at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000004">
        <property type="entry name" value="30S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005729">
        <property type="entry name" value="Ribosomal_uS10_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01046">
        <property type="entry name" value="uS10_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="5">
        <location>
            <begin position="18"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN99741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="116" mass="13028" checksum="C3540860906E7AC7" modified="2014-11-26" version="1">MDYPKKTQAAPAEGQTVRLTITSRNAKAVESVTSQLLMRARDEKVTIHGPVRLPTRTLKITTRKTPCGNGTNTWDTFELKIYKRIIDLHAPTEQVKKITSFTMESGVDVSITILDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SDT1</accession>
    <name>A0A088SDT1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome oxidase assembly protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_282840</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2</text>
            <dbReference type="Rhea" id="RHEA:63388"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:61715"/>
            <dbReference type="EC" id="1.17.99.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:63389"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Porphyrin-containing compound metabolism; heme A biosynthesis; heme A from heme O: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700623.1">
        <property type="nucleotide sequence ID" value="XM_010702321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SDT1"/>
    <dbReference type="GeneID" id="22576729"/>
    <dbReference type="KEGG" id="lpan:LPMP_282840"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280035000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_282840"/>
    <dbReference type="eggNOG" id="KOG2725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1726137at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120547">
        <property type="term" value="F:heme A synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016653">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003780">
        <property type="entry name" value="COX15/CtaA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023754">
        <property type="entry name" value="HemeA_Synthase_type2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02628">
        <property type="entry name" value="COX15-CtaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="294"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIN99916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="381" mass="42044" checksum="D3CE95821F394C62" modified="2014-11-26" version="1">MVTKTHLSTADEAAAATAAAKPWIASPHNRSVAHWLYLSAACVGGVVWLGGVTRLTESGLSLVEWKPISGVRPPLTDEEWDKEFRHYQEFPEFKQKPNMTLKEFQLIFFWEWAHRLLARSLGLVFGAPLLYYASCGYFKGNGKFLAGLIGILGLGGAQGFMGWYMVTSGLDSKLLEERRKATVSAYRLAAHLILAFTIYSFMLRMGYGLKLPAMAPFPRMAKVQLWSRLSFATMFATAISGAFVAGLDAGLLYNDEFPWMAGGIFPPADHLFTLEPTWRNFFENHSMVQTTHRIMAGTTFLTIMGLNLAASRRRGFIPPSVFRSLMFVNTALLLQISLGVGTVMSTVYVPIAVSHQMGALVLLTTLIRLCSVVGSRGLVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SHK5</accession>
    <name>A0A088SHK5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_330190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702112.1">
        <property type="nucleotide sequence ID" value="XM_010703810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SHK5"/>
    <dbReference type="GeneID" id="22578172"/>
    <dbReference type="KEGG" id="lpan:LPMP_330190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330006700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_330190"/>
    <dbReference type="eggNOG" id="ENOG502SHAQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="260528at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="441" mass="48110" checksum="AF3121E214261A70" modified="2014-11-26" version="1">MLTGDKTQTPGEEARRHDISADSQISPMSVEVHVVSPLRKQRKLVMVPSSRGDALFTTTANMPFADTGSLVFSTCTSAVRLSSFRGQWAYVVQAFQFSLTEPGMALVTTVILFTISLIGCITVFFIAPSLTTSLATRIHESLDRVVSQGEMDTLPVSWMPSVVSMMQNGLRAVLAPSVLLGAAGMWVLGDSERRRPGKLLMGYGLLVFIHGLMLLYLLLSVFFSGQLGVWQNKSLQLFQDVLGKLDGNVGQCIWEYAYSCSGFSSCCVTNTSALSMSDEELLRDAEVWRSLCFVTMRNGTALTRRHRHGEGDIFVDITKAVRDGCGEITAQMDPNEDYPLYSTACALASGSAMITPSHSTSCEDFFIGHFSSTIGFDMCLLFGMTVCSLVTGVVVLITHYQRPRMSEFMPVNTPSASSNESAIMVKVEASGDYRGANRKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SL81</accession>
    <name>A0A088SL81_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase, putative</fullName>
            <ecNumber evidence="3">1.6.5.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_354290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.6.5.5" evidence="3"/>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703362.1">
        <property type="nucleotide sequence ID" value="XM_010705060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SL81"/>
    <dbReference type="GeneID" id="22579457"/>
    <dbReference type="KEGG" id="lpan:LPMP_354290"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350051000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_354290"/>
    <dbReference type="eggNOG" id="KOG1196">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9992527at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003960">
        <property type="term" value="F:quinone reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051397">
        <property type="entry name" value="Zn-ADH-like_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF3">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="17"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO02562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="340" mass="36617" checksum="1913F107E4255929" modified="2014-11-26" version="1">MSSPSNFKKLQVISTSKDFRKSTSVVEAQLPEELPEGKVRVSVKYAGVNASDLNFVNGSYFNNTQAPFDCGFEAVGTVMKIGAGVTNVKEGDHVVLMQYGCFAEFLDAPAERCILVPELKPEYIVLPVSALTAAVALGEVGRVKKGDVALVTAAAGGTGQIAVQLLKRVYGCTVIGTCSSEEKTEFLKRIGCDHVINYKVESLDSRLHELCPKGVDVVYECVGGHVFNDAVRHLAVHGRLMIIGSISSYKSSEAIPSFPPSGTSLTTLLLVKSASLNGFFLPQFHEVIPQYMASLLQYVKSGQVQLFLDKKVFHGLSSVADAVDHLYSGTSYGKVLVEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SL90</accession>
    <name>A0A088SL90_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_354390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703372.1">
        <property type="nucleotide sequence ID" value="XM_010705070.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22579467"/>
    <dbReference type="KEGG" id="lpan:LPMP_354390"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350052100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_354390"/>
    <dbReference type="eggNOG" id="ENOG502QTSM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272567at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1690" mass="181783" checksum="616E250B6A3D03CB" modified="2014-11-26" version="1">MLGTLFFDESHVSTAFRARARQQAVAFDESSATKHLPPNSNTRVSAPDDGVVRLHDGGGLVPAHNCAFNCRGEVALPSLRAALLWWLDADVSVVQLLVVNDTHSSKATRSCQSRLLTVELPVASPSSLVICGVTRNYMGDNGVAVVWVHRGVSGEAEEEVLFPGFVQVTVQREVDTTGHSNLLLFPDEQIVQCAPLSRIPCSFFRSTLARSGSAACVVAALPDDATQRTISIVVLTDGCRVWRAELFTDGTTAVTGFRDEYRYNLLRSFCDSNEEVQLIDTRSVVADLQGLASPAASNASSLADPDTEEANTLPRGSTWIRRLLGSGGRTGANTTDGGGRPAAGGLDVALPTTVRKRLYAAVTPVQQSGLVVLTRWNGQVEVYDTTNNALQLTKAYPIGVLPEAMLQPIDDSVSGHGGKVTRGKSKLCTLPPGPIAQWATRSPTTELLHVVSCFGSGEGRACFWSTLPPLAPLSSRIIGLEQASDTGEVLAQHCTLSVAPPTQSSFPLACAVTADGRKMILVSDVGTEEDGHLLCTRSLGALTVRGEQAYEDGVTTVVQVMEAADSPGLGDLLRMGRMHGYLCQGARMQGVVAQDNAVLMVERGPQTCRLYTLEEAFPDAMRMANEGVVVGVDEEDVYATAHDTDGNDIISAYIDGAPLLLHRVHYVPLSETPPLLPGTAAPSATHNMDGFALYWEGVNVVQACPHGSRLMSDVLQDVLLATVPVTQLVSLPRFLSEAHLSGYTAALHCNGTTMKAFVRAAIRIALSPPSTAAASETAHALYYFSRLYTTHATLGELLSRIVFLTTTYLGWQSTHSLSYAFSSAAEDDAALNTAGWASHWLITALEVLVAAYHAVPVAGADLVQLALVDDSLRQPSYKAIVAALLPTLGNTTASDSGDCVATGWEISTLSMVQVANRLLHCGTPSTARACGVWVKQLVHRFALLQHYQVLSLLSTAAASTQSERTLVLCEQVCQALAREAPGDVTAALLLEGLLLTDVSGSGSAFLQLSLDEVAAFLAADPTLGPKLYAIGVLRRTTMVGSLHPSLSHSITHRYLYTTLATCIEVMERMQKCALATASAPTLVPFPQLRRALEELQVDVLLASALARVSEGDIACCFHDVQTALDFMTRHKCLPSYSELVQVILGHIVEVACASQANMNALLRATTLGAAQLEEALILRWYNYIARLPTKSATEATEALRYRAIMGLHRYLMNRHAYAECARLMSSLATLIRCSPRRRSASAGISVSELAGLALHAAEMIAPSAPMAETAAGEQARTSQVAFHGVPHDPALMMGSPLSLGYSWQPSTSASLIPFDLNAAALDAPARGPRWLTRTDIPWLRRRLYQAHCERQLWRRGCLLDCTDLWVEGAPADAYQAGVEKLVAALMQARLWPQAFRFACLSAVYDPCTVLVEWAVDLLHAPRRHGSEEAEEEEEEEAAHADRNAAWTELIGYCGELSNLENQFYAYVRTVTEALMCAYLQVPTALLAAHRAADAYTAMTTLFHVALMLRKQVEAAEREPQRGEEDGDNEEDADKLLLSSSQREAGTTAAGHLAGKRGTISLESMRCNVWRAWCAAARIGIDMASERQLRRTTVPLFQRSVGAGIGAGEVVAEEEEAAQMQPEASGERIVLDASSIARRTFSAFTAGALDPMAVCASELLRMPAYCVSLNLVAQGETTVRQFQDLMGRPCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SLM6</accession>
    <name>A0A088SLM6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_355770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703507.1">
        <property type="nucleotide sequence ID" value="XM_010705205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SLM6"/>
    <dbReference type="GeneID" id="22579605"/>
    <dbReference type="KEGG" id="lpan:LPMP_355770"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350066200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_355770"/>
    <dbReference type="eggNOG" id="ENOG502S6SQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="337581at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097196">
        <property type="term" value="C:Shu complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28498">
        <property type="entry name" value="ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28498:SF1">
        <property type="entry name" value="ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="25402" checksum="1D373B026E7269B6" modified="2014-11-26" version="1">MDTSEEGHWRVVENFPVPITRAVLDAYAQYVIASSNASDTVRPDGAEAHSVPKSVEEALAPLEILYGKTALSAIGIALHGAESIVRYVESAEVSSSDDEEAGKTSDDEEDSTHYDTHRARRGGGGAMSSTVSVHGISQPNDHASAPGVSSPLAEQRGRCLYHVGEHTLFSPYYCPCSAYAYQSIQRQEVWCCKHMLALQLVLRIEATGVTQGNLLVRIVSSAEYEQLLLHSLGIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4U8</accession>
    <name>A0AC62A4U8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Beta tubulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3320340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="XUY36742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="443" mass="49744" checksum="1E1DE6A6BC45CBBD" modified="2026-01-28" version="1">MREIVSCQAGQCGNQIGSKFWEVIADEHGVDPTGSYQGDSDLQLERMNVYFDESAGGRYVPRAVLMDLEPGTMDSVRAGPYGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELIDSVLDVCRKEAESCDCLQGFQLSHSLGGGTGSGMGTLLISKLREEYPDRIMMTFSVIPSPRVSDTVVEPYNTTLSVHQLVENSDESMCIDNEALYDICFRTLKLTTPTFGDLNHLVAAVMSGVTCCLRFPGQLNSDLRKLAVNLVPFPRLHFFMMGFAPLTSRGSQQYRGLSVAELTQQMFDAKNMMQAADPRHGRYLTASALFRGRMSTKEVDEQMLNVQNKNSSYFIEWIPNNIKSSICDIPPKGLKMSVTFIGNNTCIQEMFRRVGEQFTGMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATVEEEGEYDEEEEAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4V7</accession>
    <name>A0AC62A4V7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_322350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="XUY36703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1674" mass="186897" checksum="D60FBBC39C8C7A3D" modified="2026-01-28" version="1">MSTSSLASPTTEKAQKLKEAQLKIGMALKNAQYALTTHAHRGLTTALHENASALTALSTYLSLSGSPVKAAAIAGQMAKILKSVGTYVSAKERNSGTSQHTEVSRLSSSFNTPPSSSVVLDDLGLLPETPHESAGLVAELQRVVRELTRERDAMADEKRALEAALEESRQHSTVTPHTAFEAHSPDTADKDPDVVIRQLHAEVKGLKHEVREEHMKAAALQDQLHEAEEQIEDQQDQVQALKMQLRLSQEEKLSQDAAFAKKEEEIKALQEAFLQNSRNTAAPSSAAAAAATRSPHGYVDKDDFDALKLQNQLLQQALREQTTQMRPTDPHAVLSQQTLEEIEADHHQQLEAMKLTIQEQYNRENQLLDKQRSMQDTIDDLKRQLQLSSNRQWVQQEREKHLNEMDSAERHMEHLQETVERHKQHIPLQQTKLQHYAENERSTSDVIKNLEQHHDTQIAKLNQQIIELRDELNKACRREQELHDQVQASNTETQATIAATTEQYNHHQQHISSLTHSMAAELQQAHAAQVAELQQRLEVERDHAAANQSTAAECESALQQRLSELRTSMAAEREQHESRVAELQQAHAAQVAELQQRLEVERDHAAANQSTAAECESALQQRLSELRTSMAAEREQHESRVAELQQAHAAQVAELQQRLEVERDHAAANQSTAAECESALQQRLSELRTSMAAEREQHESRVAELQQAHAAQVAELQQRLEVERDHAAANQSTAAECESALQQRLSELRTSMAAEREQHESRVAELQQAHAAQVAELQQRLEVERDHAAANQSTAAECESALQQRLSELRTSMAAEREQHESRVAELQQAHAAQVAELQQRLEVERDHAAANQSTAAECESALQQRLSELRTSMAAEREQHESRVAELQQAHAAQVAELQQRLEVERDHAAANQSTAAECESALQQRLSELRTSMAAEREQHESRVAELQQAHAAQVAELQQRLEVERDHAAANQSTAAECESALQQRLSELRTSMAAEREQHESRVAELQQRLEVERDHAAANQSTAAECESALQQRLSELRTSMAAEREQHESRVAELQQAHAAQVAELQQAHAAQVAELQQAHAAQVAELQQAHAAQVAELQQGRELNVLRDDAAEKFWVTSQPVDWLKEENESLKVQVREWEEKHTEVTNEKVSAVVKVGEVEEMLSCCKCELQRLKAEYSSLQKTMSKSLEDRDIAVKRLKESVHLTEEAEANVVRLETLRKELQEVQERLEITDKDRALVVSRYRRATTEKEECADAARRLLTEYKEMAATREKLVAQLAAAEALAAERSREVEELTRAAPAGASLKSSGPRDDALEAVGQKVVQSTVSEKQERIEALVCELEAVTRENKRLRSELEVAQVRQAAPRRASLTAEPTSMQSAFAQDMLSSLAGMRVTLNTMHTQLVPILEQIRVEERSRAAAAVDPSASTSAVDALEKLYTSMESVHAVTQATLEDFDIGARQLRVSAELQAVVYGKLLATLQQHRGKGATSPLTSTLVDVSLVRACTALFSELSTGSTPKWEENERHGEQQLISHTDQRYCPGRASSATRDYVVAAEKNRRVAVSATAHQQSPSTWSHYHAFSSAPSVFASSVGVDNRGRYSRTVNHARRRADDRELFILDNAGYGRQPARAGSRYQSSFENFAMAQASISVAEERARLRTAPTPPWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5B3</accession>
    <name>A0AC62A5B3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribosomal protein L1a, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2920020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="XUY36937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="373" mass="41128" checksum="E4D73F8F31F6F8CD" modified="2026-01-28" version="1">MSARPSVSVYSASSDSVVGTCPLPAVFTAPIRSDIVQFVHTNMAKNSRQAYAVNRLSGMNHSAHSWGTGRAVARIPRISGGGTSTSGAGAFGNMCRGGRMFAPTKIFRRWHRKINLHQKRFAVVSALAASSVPSLVMSRGHKIENVPEVPLVVEDSIQGYEKTKEAVAFLKAIAAIDDVNRVNDSREIRAGRGKMRNRRYVARRGPMLVMPNNQGTRAFRNIFGLDLANVSALNLLHLAPGGHVGRFVIWTKTAFEQLDKIFGTFTEASAVKKGFTLPAPMLTNTDVTRIMQSEEVRRVLKPKKLQPKKASRYQTPTNGIKNRRLRLRLNPYVKRETAAAKGMRNVANRDARRKAKMARVAKARKSATKSVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5D4</accession>
    <name>A0AC62A5D4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histone H3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1620560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="XUY37067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="66" mass="7238" checksum="D87F239EB5F19D1A" modified="2026-01-28" version="1">MPCARCRACRRRGGPALPEQRDPGDPGGVRCVADGCHEPGQHPREACVTVRPKDVQLAVRLRGERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5L5</accession>
    <name>A0AC62A5L5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATG8/AUT7/APG8/PAZ2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ATG8B.2</name>
        <name evidence="1" type="ORF">LPMP_1920210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="XUY37142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="118" mass="12274" checksum="A4EBC961EE5BB0EB" modified="2026-01-28" version="1">MSAYQSSNTAEARRAECARLQAKYPGHVAMVVEAAKSSKAHLLALPRDATVAELEAAVRQALGISAAKVTLAVEGCTPAATAAVGDVADACKHADGFLYVSVRGEQAMGIFSLCFPFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5U2</accession>
    <name>A0AC62A5U2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amastin-like surface protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2020220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="211" mass="23611" checksum="2D15D5C9B7E850CB" modified="2026-01-28" version="1">MSNFSSEKTQEPEVASATGTETTEKHSTDSDLQVSLVKGRIGLIVYVIVQFFAFFFVLFGTPIDMFRLRSSPSSPDRSVVTTLWGLKLGVFSIRYGQNSDERWRNCTSRLNRFRLAQAFALISIFVYGTAFVLGLILLFCCSYLRWVCLALNIVGAATVCVVWAAMVVTFYRNESSCLELGSIYNYGSGFTLLVLAWVLDILNIISLLLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A636</accession>
    <name>A0AC62A636_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2021280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="315" mass="34008" checksum="411CA8385A93171B" modified="2026-01-28" version="1">MLSPVQLRHQLRVAAAVTQRLHQRSQRLEKEVDAWKHKYAGLEAKTAAEMREVGIDEGKLTERQTFSASLPDGTHPHQSIVAPSSLTAAVAATASALAATQSLEVTEARSRQLETEVKRLTAHKQELTKRLYVAEQTVGALKEKLRIMAAISPATSSAASSPLGVAKTTAGESASDKSRSKALESGATTTPTRAPPSPSGTATKSEMVDPCSDGTVCVDGAGGESFACLRSTVRELQRRLDLSEARVEQAEQIHLDALLLHRESTPSAVALVNAEVQKLFQLMQQQLLSNAVQQQAERARMSELLYQLQCQQRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A688</accession>
    <name>A0AC62A688_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Beta tubulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0820330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="XUY37313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="443" mass="49831" checksum="AF2AEE5526A767AD" modified="2026-01-28" version="1">MREIVSCQAGQCGNQIGSKFWEVISDEHGVDPVGSYQGDSDLQLERINVYFDESTGGRYVPRAVLMDLEPGTMDSVRAGPYGQLFRPDNFIFGQSGAGNNWAKGHYTEGAELIDSVLDVCRKEAESCDCLQGFQLSHSLGGGTGSGMGTLLMSKMREEYPDRIMITFSVIPSPRVSDTVVEPYNTTLSVHQLVENSDESMCIDNEALYDICFRTLKLTTPTFGDLNHLVAAVMSGVTCCLRFPGQLNSDLRKLAVNLVPFPRLHFFMMGFAPLTSRGSQQYRGLSVSELTQQMFDAKNMMQAADPRHGRYLTASALFRGRMSTKEVDEQMLNVQNKNSSYFIEWIPNNIKSSICDIPPKGLKMSVTFIGNNTCIQEMFRRVGEQFTGMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATVEEEGEYEEEQEAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6T8</accession>
    <name>A0AC62A6T8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycan beta 1,3 galactosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0220050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009371">
        <property type="protein sequence ID" value="XUY37390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="817" mass="89768" checksum="8965C80AA79CDCB2" modified="2026-01-28" version="1">MSGVTSPLVVKRRTNALRGSATWDMTMVPPLATEGSGESYASVGQGPLSNISPIADNISSPHLSDSHSHDFSACGISTSSPTSRLRHSCLSLKLPLGKLLGSGACRVVHRFVSALALLLLLYVLTATQFLENARLTRVENALDHLVNLQDPERGPWSVLVQHEDALQRLNFTHQQRCRVGSMLCDPLVVGAAFLPSWTLHVVEKGCADCTDQQTYASAVEGVVLQARHAVFATSAAPLGRVGPMLLAMASVTDDVDVRAELPQWEWLRHVHGSGFPAVGGAAGVSAPPRAPYLAVMGIPSTDQRPRAALREAQRKTWLAYQEVARRDNHFTGALLALYVFAAAEPDPILDPSEDSAESLHSGTSAASPGRAGLRVLLPTTAEYKTATQALLARAMQADGVDGVAGEGFAQRRMELRRGWSTAAVDGSPCAEVASSWTAGGAKTSALSYLSRALSLPVTPAFTSPAEYICHASSALWQEALTHRNVLWIDMMTDRRPTTKKKLGEPTKWGLPVEVGMSQKLILWLAYAYHAFKDVPFIIKGDDDSYMKVPQFLSDVRYVMGGMQARPPPPPADAANRSTYAPDMGRAECMYWGSMRVFQNAQFNAGMTFMLHRLLARVVLEPPGEEKRVDIAEMAVMKFDMNLSAVYRAARFHQEDILLGLLIRNALRRARDICPNNRVWFIKEGLARFHDMHRGAEHDVTWSTVVAHRCTPANNYYLHHFFQREHYATLASSGGKRRAERAAVAQAAEWVAEHRRAMGPEVVGWDAMPAVQWVRNVKRTPAYDMAEADGVPVYRIEYKYWAHQFTAVDDGLYSLPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RH53</accession>
    <name>A0A088RH53_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Calcium/potassium channel (CAKC), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LPMP_010790</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009370">
        <property type="protein sequence ID" value="AIN95178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696720.1">
        <property type="nucleotide sequence ID" value="XM_010698418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RH53"/>
    <dbReference type="GeneID" id="22571808"/>
    <dbReference type="KEGG" id="lpan:LPMP_010790"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_010012300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_010790"/>
    <dbReference type="eggNOG" id="KOG1420">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="257992at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003929">
        <property type="entry name" value="K_chnl_BK_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047871">
        <property type="entry name" value="K_chnl_Slo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027:SF37">
        <property type="entry name" value="CHANNEL (CAKC), PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03493">
        <property type="entry name" value="BK_channel_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22614">
        <property type="entry name" value="Slo-like_RCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="15">
        <location>
            <begin position="206"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="16">
        <location>
            <begin position="293"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium-activated potassium channel BK alpha subunit" evidence="14">
        <location>
            <begin position="428"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="590"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF22614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AIN95178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="984" mass="111322" checksum="53F1CD853E124643" modified="2014-11-26" version="1">MDKHRSSWREWFRLGRRSDRPQVFADKHYAHSEHPFLSLRKFVEFLDRRHTNVSIFGLLMHITMEIVSIAFYVWTSHVTAATSATEFTWSVPVFITEVALSIIFLLAWIGLFFLEHDKKAYLISWLSLVNAMTSIPMIVIGIGALKDSLWRSVWVPMFLRVWWLCDSLNVLIDYPQIARRTPEVWREMMRYFLRLLAVMGTCIGTHQIVESCSGQYIDLYDSLYLIIVAFATIGFGDVTSITTPARVFMVAFIVIGICFFLPLFQRLALIAERRQFHNTFSGGSASWFRRGWKHPHVIICGQFSDLSVELLLRNFYAGWRKYLDTCIVLMAPEEHSPEVRLVANLPWLKSRVTLMVGNPENSKDLDRAKARDADAIFLFGDSRSAAYYQDYTIVAQSVAVSLYDRNLPQHLLLHRNCTVKQISPYAASVLEVERTLHHLLGLSMTHPGVVPLIINLLRTYESLPSDITLSRDWVEQYEYSLRNDMYGLEIPDALRGREFRVLARAFFEKDVTLIGILNVRSVVQLNPRELVPNARKLILIAKTMKVAQDATDAIARDYEQTFGEEMLVAPDPDEHDRAKRRLVRSRYHTEFSSNDSTLDDNVGSVNGTAKQRGPPMRPHGAEAVLETPDPLGRLSHVPVSLQTTGSSIAAEGDFDDEFDARNSSVGAAPSLPSSVHPSEVRSEALVRIDDAFDLENHFVIIDLSTAKAKDESSRYAQEAVSTAVAHDIFHVTVPLRQAHPTSDIVLLTNDVSFGPYFDYYWSVHHQDSAHPVKYICGCGLNTADLRRCNLERCAGCCVFYAGDISLSGSTSAMSMLTVLSINDILHGIPAFPVVVELEGLVNLPLFPPHAEDPRLRSKAEIDFVYEPNFIIGNAVSRLMLFPALQRTYFMEEFIDVMDVLISGHAPDTPALARLPLSLCEADLHIYEDVVIYCLKFGFLPIALQRRIVDMCNPSINGQRFVLTNPPRALPVRQQTDLVFYITPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RH79</accession>
    <name>A0A088RH79_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Rhomboid-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_020330</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009371">
        <property type="protein sequence ID" value="AIN95213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698178.1">
        <property type="nucleotide sequence ID" value="XM_010699876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RH79"/>
    <dbReference type="GeneID" id="22571843"/>
    <dbReference type="KEGG" id="lpan:LPMP_020330"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_020008200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_020330"/>
    <dbReference type="eggNOG" id="ENOG502S5CX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273673at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001838940" evidence="7">
        <location>
            <begin position="27"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN95213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="375" mass="40300" checksum="88F83CF75D13FDFA" modified="2014-11-26" version="1">MRIDPICTAIRFAPVLVLLNVHCSGGRWPTDADCAERVMRYGFSVDLFSEQPARVFTHLFVHISSTHLLSNVFSFAATLVEFGNMTDPAAPSAAARLSDTSHDGEGRGATSGAATSFATQRMALEMCAIWGEQSRLQACARSAGAFLVWAVGGAVGGLGCQMLYNSFALALRRERAARAAAAAAAVANTKHSAAPGSAAERILDSIGRGVKTLWQRVEVYSSNFAVSAQEVVNNEMLMCGASAGICALSGFSAVCYGRPITAFCLAVPEALLLTADIIHLYVAQLAPERGAPNSVAEAARRALQSAWRVRMPGQTVGHAAHVGGFVVGVGMGYCWLWLQRKWRRWRLHRMDSRRCAAQLLLRPVLHTCVHRRSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RH86</accession>
    <name>A0A088RH86_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_040100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="AIN95337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703659.1">
        <property type="nucleotide sequence ID" value="XM_010705357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RH86"/>
    <dbReference type="GeneID" id="22571969"/>
    <dbReference type="KEGG" id="lpan:LPMP_040100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040006700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_040100"/>
    <dbReference type="eggNOG" id="ENOG502SE36">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267616at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="154" mass="17478" checksum="6452D2973A85CD26" modified="2014-11-26" version="1">MRRCLAPAGARVASRRSSTTVSRPVDYNLRHCSLWTENGANNTASATSTTAPVAPTSEDYRALLLDLLLYRRETLAPVVEALRRERDEVEKKMQQLDTHVRELSFIRDELRQLSEVMLNGERTRLHDVVMEHRISSAAESSNAAEREESEEIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHA9</accession>
    <name>A0A088RHA9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_010340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009370">
        <property type="protein sequence ID" value="AIN95135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696677.1">
        <property type="nucleotide sequence ID" value="XM_010698375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHA9"/>
    <dbReference type="GeneID" id="22571763"/>
    <dbReference type="KEGG" id="lpan:LPMP_010340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_010007700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_010340"/>
    <dbReference type="eggNOG" id="ENOG502SAM1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277140at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="211" mass="23680" checksum="C954B400740A3AF3" modified="2014-11-26" version="1">MMSSTVYDFGYELASKQVRVYQTNDVGSVYRALTANLQEYLAYEGIQEEDPTSLKNMFVKVLTVGVGVAVYVLCKSHASEVLLAGSFLFFGALVAFQLVCSILQHNGNIIFIGSGRVVEDQQRGQKPCFRKLKNQRICIRLTQENMFIPVVKFEVQLIGPSRMFSPPTVYSRVEKTVQYGQFFGSTGFFFPPALQELIDGMLEAVASKKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHI0</accession>
    <name>A0A088RHI0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_040160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="AIN95343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703665.1">
        <property type="nucleotide sequence ID" value="XM_010705363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHI0"/>
    <dbReference type="GeneID" id="22571975"/>
    <dbReference type="KEGG" id="lpan:LPMP_040160"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040007300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_040160"/>
    <dbReference type="eggNOG" id="ENOG502SD5C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273723at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="432"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="432"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="442"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="457"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="468" mass="50920" checksum="76888F85BDB89578" modified="2014-11-26" version="1">MLQSNEGTQPLPGSTMTPSPGASLGVRAGEAVDHHSAQKTEALPLADLLIRASDAIRSERGRADSMEKENNKLRAQLEGVRSAYQSVATQRAQRSSQTLASVTTYNKAVEDTLFAYVRDQLIGPDDNYTSGNNGGNCTTKINSRTRPRQSQWSSSAATSSVASVAARTPPRGSITPWAQRWTKGWDAQITPPEPAPQRIAVRNASAAAKECVQRVYSSAALRHRDLKTGNDHLTSSLTGDGSCKGQGSAALEGYNNADESPTHWMARRLLRALAPRPTDSAVGDIVHTMVTALQQDVQAELDRPRECNNPVQHRPRGFALVRLQPCVYRLLVGPPAEVKAMAHAARVHNSGACPTTARLPSAAPYRDHFLLYCTNQGTPNASRTCHSQVTNTVIRLTIDTGTLRVLRGGGHVDFIDYLEHHLHITLYNGQRTSTQQSISSPTHRRLQPQPHKPRPSTAHTNHTATHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHY2</accession>
    <name>A0A088RHY2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sre-2/carboxylate carrier-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_050660</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sideroflexin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="AIN95508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703830.1">
        <property type="nucleotide sequence ID" value="XM_010705528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHY2"/>
    <dbReference type="GeneID" id="22572144"/>
    <dbReference type="KEGG" id="lpan:LPMP_050660"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_050011200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_050660"/>
    <dbReference type="eggNOG" id="KOG3767">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6608471at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:monoatomic ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990542">
        <property type="term" value="P:mitochondrial transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004686">
        <property type="entry name" value="Mtc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153">
        <property type="entry name" value="SIDEROFLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153:SF6">
        <property type="entry name" value="SIDEROFLEXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03820">
        <property type="entry name" value="SFXNs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN95508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="346" mass="37643" checksum="B6D718F8D4914BF5" modified="2014-11-26" version="1">MKPLSPDATLGEVPDFPHDLQSNQSTYKGRFLHFLSMTDPRTLLTSPTRLALSEALLERVDSRKEGWATVRVADYLDARQRVQCIVHPESKKPILMPFRFSAFVPMNFLNLCGMLAPSQQTPARAVFWQLSNQTYNVGFNYCNASGKDGLPLHELAMGYVVATCTACGTSYQLGKVASAVSASTSAAAMFLKLIIPYTAVACANMANLGVIRFRDVLCGITVQDTETGEDLNGGKPSAVAGRLAVAQVALSRVMIPVPLMLLPPVLMNFLFHPANGVRFFAQHRARLYVPVNVLTLVSMLCVALPMSVAVFPQRTVVPVSWLEASFRGQTNAAGHAITHVTFNKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RI28</accession>
    <name>A0A088RI28_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_060530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703934.1">
        <property type="nucleotide sequence ID" value="XM_010705632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RI28"/>
    <dbReference type="GeneID" id="22572259"/>
    <dbReference type="KEGG" id="lpan:LPMP_060530"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060011000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_060530"/>
    <dbReference type="eggNOG" id="ENOG502QUM8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="31113at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171:SF12">
        <property type="entry name" value="BASIC IMMUNOGLOBULIN-LIKE VARIABLE MOTIF-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-G CELLS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="554"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="742"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="828"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="742"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="832"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN95612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="852" mass="90064" checksum="FCF7737254E4104B" modified="2014-11-26" version="1">MDHLCVDPHDAAATKIEMCEVDSAPDTPVAVVAVNEGADASSPALEEEQASADEDGGSIGDALCEVEAEASMFLQASAAELAPLQLSALTRRVEIAPLNAMTILSGVPVVSAVDEVYVPAPPNAYATSMAGYSQSAAAPEEDDAAPVGLWISPAETRIDLTAAAEEGASQELYDRQQQVQLQVDGTASSPREVPVTAAEVSDSQAWAIDFAPAKRMPTRKMTKKEKDAIKRLRVRRQTMGADSEGNTVVPVDASALTGSLSSSPLQVVQLDTLALDRDALIPVNLKTTRADLEARLVLRLPRLLCVNKQYPRACGIASLTSVYNYLYSWLGESAVGTNRPPHSQEEIMSILGFEPPFGEIAWGSFTGNATLIRWFHALNRHFGVRGRAYILYKVHGSGKTTHLYNNNTDALAAVKAALRDPHCALIYHCHNHYMVPIGYQDIPLAQADFLKPTVAESSCDTTIFIGEVSRGRHEAMYARKWSQIVKDIECKSPFFFNIRHPEQGVQRREPKKKLSKEGADEGADVTVRAVAATATTATTTAAVAVAATAQMRDADGLQQRQQKRQAQELQGGNSSEAHSPAETILVALPNAIPHSGATVLRGISDNDVDADFLDDAASNTSSDTIEVMVFAATTTPPLPPAAPSTFLQQPLPHTSSSPAVSTMAALKPGLAKSPEDVGDGLSIATVVQLQALAEKVVAVAQPGVSHERNVSVSSAAQSAPLSPSGAASAPLANNAMASMNEAVSSVPASSPLPASSSPPPQQQPKLRTAYAGMDSAAEASHFPRSSPSPAGPKKERGNLHCIICFRNDEVEPNLGRYEDTALWVAGTAAASPRSSVSSLPRGGSFSSNEADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIL7</accession>
    <name>A0A088RIL7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_080180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="AIN95827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704149.1">
        <property type="nucleotide sequence ID" value="XM_010705847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIL7"/>
    <dbReference type="GeneID" id="22572480"/>
    <dbReference type="KEGG" id="lpan:LPMP_080180"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_080006600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_080180"/>
    <dbReference type="eggNOG" id="ENOG502SKPM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10257471at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050715">
        <property type="entry name" value="LRR-SigEffector_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45752:SF187">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45752">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN95827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="644" mass="70381" checksum="F81A25F97AB921C5" modified="2014-11-26" version="1">MLELVASFLPQPSLAMIAAGPGVRCAAERRDGVGASSTLSFTVERVPARYARERDACLAPVAGVREVMVVTCRGAGRKDGAQTALKVGMWWVDRCLSRAAQQAAGETAALFCCIRIVDVVVERLTLYSSEDSPFSGAPSPAHMLMPQHFFVLQLFRLAELRHVQLSPSVRRLVVEVDVRSCLRWSQSDVNALLASLQSPLRAVRVTTCSVSPVKLLNKFHASLRVLYLFRRRAVHRDPTHTRMTVSMEDEEYEDEESNRSLSVAPAVDAHVTASSASGLPAAATGAKLMPLTSMTVTPQSTSAALTTATGTRRRRPEHLRLSAATTAAPALEELHVTSSSLRSLPRWVESCTQLKHITLRNCAYTRADSLRSARALTTVLLEGCPNFVGFDFIYGLPALLSVTVKNCGLLRDLSWLPRLKGSLRSLCIHHLSSASLTVFALASFLGTGLSGLEELNLSVPTLHVLRPFVSQAAATLRVLTLFTCINLSGFSDLPALPALEKVVITGNRHMQNFLWLAKSPRMVEVRATQCTQLVSLAGIDALHHLRLLDVNGCQNLCSIAPLAKCVFLTYLDVSQCRLLRRVSVLENLSCLQCVLMRNCTSLAKDFGWVEACPKLVEIMVPGSAWVEPARSALCRFGRRHVVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIN9</accession>
    <name>A0A088RIN9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chaperone protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_070820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009376">
        <property type="protein sequence ID" value="AIN95768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704090.1">
        <property type="nucleotide sequence ID" value="XM_010705788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIN9"/>
    <dbReference type="GeneID" id="22572417"/>
    <dbReference type="KEGG" id="lpan:LPMP_070820"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_070013600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_070820"/>
    <dbReference type="eggNOG" id="ENOG502SCZ1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273898at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="40"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN95768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="367" mass="40699" checksum="492FF191591D8F0A" modified="2014-11-26" version="1">MRTRSFHRAVTATGFLYRCISSGSSQHQQRQCVAAGELRAALRTLGLTEESTDADVKRAFQAFAIQHHPDTNTALVAAPSDAGEAIRGNERSAAQAAERMRLGTEAYHLLRQIPFEVRRHILRGEGRLRGPHDTPFVFTEEEYAKVQRVYQGDHRRRRHRGGRGRGRCDGDSGEDLFDTRTEEGRRRIARLNEFQARIAEMRRRGIRDDLPPWQVYESGKGAGTAGHSGSASTSGGSVGDEQQGRYGSPATYSGPRNPHRLGLHFFNATAASLRGVRDLYRSRPPFLGMDCSSYDRPLSAARVAPEISASTYLRQYILMKSCAQGKAIADRVMRWPLRQLLLLTCLSAAMTMMAAIVGSRPTGLQKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIV7</accession>
    <name>A0A088RIV7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_080290</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="AIN95838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704160.1">
        <property type="nucleotide sequence ID" value="XM_010705858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIV7"/>
    <dbReference type="GeneID" id="22572491"/>
    <dbReference type="KEGG" id="lpan:LPMP_080290"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_080007700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_080290"/>
    <dbReference type="eggNOG" id="KOG0438">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268576at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000068">
        <property type="entry name" value="Putative ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="5">
        <location>
            <begin position="253"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="340"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="347"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN95838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="427" mass="47858" checksum="88AEFA8263C1C80B" modified="2014-11-26" version="1">MLRRQLQFFTIGGVSAVSAAELTGMGPSSVAAAATGPSLSSPTTLSIVAGASALIVPRRGVKLVNPIGKQGSQHYGLEPKLEAGKDTQLKHTEMYDGYTDDFGVFKEGPPVTLRLEYVRSPDHGYSQHILQKDIWSPFQVGANMMSYTPLYYDWKGFSSRDYFGHRSGTNPGSKVLLGHYRRDEERSWGYRIMVNHKPQKRIPKWLACVVHNRRKKTFLGFFLYANGAYVAELLTYKQLPRIIYNKAFQGCLPTVGQTVSLTEVTYGKEMHSVEMYPGHGGVICRASGTAAVVLRGSEPNLVPLLLPSKEVRLFDSTCHAVFGRRAGVMYNKQRNFSKRSIEENMPHRPKVHSKTKRVSSHPAGGGNGGSPNLLTPLDWRIHPRNCVKTKYWLSGYILRGRQYNRNQTVADLKSKTYSWANRDPVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIX9</accession>
    <name>A0A088RIX9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_070540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009376">
        <property type="protein sequence ID" value="AIN95740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704062.1">
        <property type="nucleotide sequence ID" value="XM_010705760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIX9"/>
    <dbReference type="GeneID" id="22572389"/>
    <dbReference type="KEGG" id="lpan:LPMP_070540"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_070010600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_070540"/>
    <dbReference type="eggNOG" id="ENOG502S0SG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="278124at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="178"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="395" mass="42711" checksum="DE9FC8BF605E9967" modified="2014-11-26" version="1">MSSSASLSFTSGGAPIEGARGGEPAAAPSSSPTSSSSTSSYSQWWQRLYSAHTFTEGLRVVFEVVPLWVPVAGMVTTAGTYYITFRVRLFLAQWRIAERRRAERKYDLLDNLRGMTTVPVGAVHALDDDDDDDDDDDEEEDETAVSRRDVDEFRSSLGIRLPRDEDLMAIVERMLMSDTLPDGWVLYRTSAGIVRFMNLNTQELFFFPPNKRKERALIESELKKRNREAMESRYNFSYEDEGMNSSSLSPSRADPQNFVPSHRSSHEDSGHTGGNASPIDFDDGAGVEDPNDGLSSTFRRMFSYFLEREQKRIEQGVALARSSREGSALSGFSAGSSGNAVGGSGSGQGSGSGAGGASGTAGAGHDGAIAHRSTASMTYRVVSSSSIHGGRGGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJ02</accession>
    <name>A0A088RJ02_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_090460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN95962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704284.1">
        <property type="nucleotide sequence ID" value="XM_010705982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJ02"/>
    <dbReference type="GeneID" id="22572616"/>
    <dbReference type="KEGG" id="lpan:LPMP_090460"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090009800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_090460"/>
    <dbReference type="eggNOG" id="ENOG502S0Y5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273554at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="740"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="931"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="982"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="464"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="577"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="841"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="997"/>
            <end position="1021"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1021" mass="109272" checksum="498FDD6D16C6EC93" modified="2014-11-26" version="1">MSVTPLGARRPPLATIPAFNAAENAASSTPSSSTAQGAPPLTQSYLHHTPPSHSNAQLLAGMNPTTTSFLSGLSTGFTSPMSRIAGTEAILEPPPTENGTGDGARQNASAAASTATVATSDDILRGIYNEKLQASVRSIIMTLTTELPQDHIFLQLLADPTTLQYCKVRLGEVVEGFLYSTQAEQYHALATEFARGERDCAMLHQRIGDLEAALALTSAPAQSSTPQRPGPSPLVVPSGTSVDHAYQAAQAALPWTSSPTMMPAQAAAAPTTSSVSPSIAVNPMENEEARRELLRVLEQATHDQELHRCTQALHAVSKVVDIAHDEVHYDDKYLFEGELLGELFKCVHSLLHYVDSALESQERLRFEVQEQQQHWLYGAAADNIKSINDGAVGGSAVSASHSAFASAGAKVNSAPGALLVSGCSTPRRPQVSLGNAGTALMSSAAGSRFSSVSSPTGVDPTRPIQQQRERLQRLAEQLREGQQHASQVLQALAHMECTRRREVAQLEREVAITREEAAAALSAAEGARQVKESSERLRAEHAASVASERTELRDQLADAHAQLAVTTQDVYTARRELRSTTSRAEAAEEREKNLVAELDALKAAMARRDAELQEQKADRVTRQAELTALRAAHQLNIDALQDSGRELLCLRVEGTMAGLAALYQEAKAAKAELLEREGYRPLFHRCSIAVASQKEAARHAQAQSQLAESAQVEQAVAQRGCMDTLGALLRSMWADDAIESSLTSSSPSTVPPAPSAIHLTDGDDTTEAARGGSTASGNVAVPGAVNIRGSPCYRLPTTLPGLCTSLEYAYDNVRARHRARQQTIDLLRAELVSNDIELRAAQASEAQLRELLRAEQSKEEQWKAEMAQLSEHNPMRGLLARQDTLLKAVSDERNELRRLWNRLTGDYIALEQRNGVLHARCAEKEHENARLSGLLRRGGTSTTSTGSQHRRAASYGAARVAAAIPAAVSTATEAAPGPRTLATAEAQLDTSAGHPVSTRGPDSSSSSRSDSTEASSNKALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJB9</accession>
    <name>A0A088RJB9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_020490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009371">
        <property type="protein sequence ID" value="AIN95229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698194.1">
        <property type="nucleotide sequence ID" value="XM_010699892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJB9"/>
    <dbReference type="GeneID" id="22571859"/>
    <dbReference type="KEGG" id="lpan:LPMP_020490"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_020010000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_020490"/>
    <dbReference type="eggNOG" id="ENOG502S1XB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273109at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="237"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="6"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="143"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="321" mass="35605" checksum="71BD041F5A2125C4" modified="2014-11-26" version="1">MSEELILQWTKRVSDAEEELSRMEEDINAVKQQRKSLKADIHKYEDVVASEKCDLLTSLERVEAQAKDLGAQCEETLTEKDCAEREYMATLDAYENLHFLVREIKDAEEHLQSRDDLETRLQRESVIWAEEEHALRRTLHQLQQQQTQTRRAQEAELRELEAQLLNVEQRQRDERAGRCGATAQATRLVVRSSRQPTPASPKSVVPAEEDAFVRANTGGAMPTRSAPLRSCLKMPVSGHTSGNAAATAPRPPTAASAPVSRCASQSLVSDSAASGVGRQGIDGGDRPSLQVLPEMRAYSYGAPAKPGARKREFLGDTTNNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJK5</accession>
    <name>A0A088RJK5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar protein 56</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_100190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696741.1">
        <property type="nucleotide sequence ID" value="XM_010698439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJK5"/>
    <dbReference type="GeneID" id="22572755"/>
    <dbReference type="KEGG" id="lpan:LPMP_100190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100007100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_100190"/>
    <dbReference type="eggNOG" id="KOG2573">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6780543at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000005">
        <property type="entry name" value="Nucleolar protein 5, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000004">
        <property type="entry name" value="Nucleolar protein 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Nop" evidence="7">
        <location>
            <begin position="302"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="446"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN96088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="471" mass="52519" checksum="46B9920A4747B122" modified="2014-11-26" version="1">MSKTLYALYESPTGYAIFKIRTTEEIGAENVVLQKTLQDFSTFSPWVKLVSFAPFESPENALEDAVCISENLISAFLSNFLTAAFAKKVAKDEANWELGVQDPKLGSAIHDELNIPVLCNENVAEICRCIRLHAEKLLPEHNEGDVPRAQCGLGHAFSRNKVKFNVHRSDNMIIQASALMEHMDKGVNLLGMRVKEWYGWHFPELAKEVPEPLKYANVALLIGNRCSLEEAPEEDVKARLGDILEGDEALAARVYEKAVTSMGGDMAEVDWDCIRTFAKRVASLGQYRVALAQYLVDKMMLVAPNLTQLMGQTIGAKLISKAGSLTNLAKSPASTIQILGAEKALFRALKKKKGNTPKYGLIFHSSFIQRASKEHRGKISRYLANKAALACRIDCFMDAPPTVFGEKLREQVEARLNFFDTGNKPPSNKAAMAEALEQYQRILRKRDRKHAEKDVEETPKAKKSRKVEASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJM0</accession>
    <name>A0A088RJM0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Folate/biopterin transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_100340</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696756.1">
        <property type="nucleotide sequence ID" value="XM_010698454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJM0"/>
    <dbReference type="GeneID" id="22572770"/>
    <dbReference type="KEGG" id="lpan:LPMP_100340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000040900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_100340"/>
    <dbReference type="eggNOG" id="ENOG502SMBE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="754047at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd17484">
        <property type="entry name" value="MFS_FBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039309">
        <property type="entry name" value="BT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004324">
        <property type="entry name" value="FBT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00788">
        <property type="entry name" value="fbt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585">
        <property type="entry name" value="FOLATE-BIOPTERIN TRANSPORTER 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585:SF51">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03092">
        <property type="entry name" value="BT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="427"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="457"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="488"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="520"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="558"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="604"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="278"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN96103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="682" mass="74156" checksum="7DEA79843E25A476" modified="2014-11-26" version="1">MMAKAQAHDGDLNEKRRFDHHKNAGATAAKKAVHPEAASLFATCSWLRRVPIFGEAVEGYGPKVIVALGGCYLMCKGIADRVLTGQTYAMMIDRYGIDVARYQRLSPISTMGWSIKAFTAMLCDGFAFLGYTKRWYMFVSCVAGGAFALIYGLLPAKESSADVAAALIFLSSWGKANVDILSEGHYSRLMRQNPQPGPAMVSWIWFWIMTGALVATIMNGPLADAGKPQISIFVSAALQLATCVFYVFNWYGEKKNRVLRSEDALYLLEETRRERARLGLEAGTDGQAGAAAKGKRSPQHSHSDEDVDAAVPGGLHDSRALVQDDYYDDDSEAVADGEAYYGKPPVPCLLGLFEVNTEVISKNWRIFVYSAVMTCAVIAMLCANILADTLGLLMACVVVSTICCCSSFWALPLVIAKANVFGYLQQAVYINIASPLMAFYLNSYHCPGNLPNFSYSFYNTVAGVIGNVAGLAGVTAFNYIFSKRSYRLTFCVTTFAQVLGGTTDIIMVKRWNLYIGIPDHAMYIWGAAVVSEVCYMLGYMPMVVLVSRLCPRGSESVVYALMAGFASLGHSTSASLGAILMEYALPVFKMQDDGSRCNFDNLPLLLFVCNVCAPPLVLPLSLLLPKGRICDDIDIDSKVVRKKVGEEVMAGEAGELSSPLPTSAECAKATVAQDGHVKRMEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJP8</accession>
    <name>A0A088RJP8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flagellar glycoprotein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_100590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696781.1">
        <property type="nucleotide sequence ID" value="XM_010698479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJP8"/>
    <dbReference type="GeneID" id="22572795"/>
    <dbReference type="KEGG" id="lpan:LPMP_100590"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100012400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_100590"/>
    <dbReference type="eggNOG" id="ENOG502QRH7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="342730at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="463"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="493" mass="52772" checksum="AECFB78E653DA59A" modified="2014-11-26" version="1">MGRYGVVGYGGAMVKDGVVFSDMGGSGSAIRLISRNGYISTIAGNLSRKGNNDGPSTEALFGGIASGDSRSNSLASGNGGYYVADTVNSALRFINTSTQTTITILNASVLRTPNSLAISIIDDKTSVFLSNTGLHQVLYIPTLSSPVGQVNFTSDPFFVPGAITVLPELSRAFIVNATLQIYCWSYAQPGSTSWKVSDPRVADFGRILTTSSDGTKVLYVTSNGSTIASLSAIASPTASPALIPEKMIDFNTLVIGGRVQLFFERTPDSWYILTTTKFMIVSATPIQPEDSSSDSDEILSGRHRGLAAFPTEAFPINDSCLMAQAYHWMRMDATEAYNTTDYLSEFLIPPNNSTTTLVYGDMNVSGWCGNITADLSNDHTILILTFWGPRGYTLQLTQDRLVTSTWTRTRAFLESLKNSGWNLGPFCFFNCTTTCKTITAPKCLVNTESACDDVCRGAIASSVVMAAAGIVLIILMIISPSNILAAVVMVPII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJZ6</accession>
    <name>A0A088RJZ6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein mS29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_120040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS29 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009381">
        <property type="protein sequence ID" value="AIN96332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696985.1">
        <property type="nucleotide sequence ID" value="XM_010698683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJZ6"/>
    <dbReference type="GeneID" id="22573010"/>
    <dbReference type="KEGG" id="lpan:LPMP_120040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_120005300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_120040"/>
    <dbReference type="eggNOG" id="KOG3928">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="274828at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019368">
        <property type="entry name" value="Ribosomal_mS29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10236">
        <property type="entry name" value="DAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN96332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="467" mass="54238" checksum="5E0DCD576E5166EB" modified="2014-11-26" version="1">MWEGAIPLKHERVVNNGIATHVVKKTYAHPPEIHPTNLSFNDIDSMYCLGNDELIKYFPEGVGGKVMQLMPPSHPRGFLYRKQSHLLNCFIDKLPFWQSKERALRSLTNGRPGLIMDGPTGSGKSALLCQAVHYARSRNIITLYISNAKAWTHGEWCWPSTILPGFFDAPDAGREFLRTVAEANRPLLQTWELRVTPQDLPLEQGEKQPRSLYDLCEWGHRAVAPASIDRQSVCIKFFFDEVSAEKTKPIVIAVDGWNLFSHETHFRYPHPDFLRTLTTLNDGSTDVDLYPQELPRIPASRLSFVRGLNKLILSKQDPNKFFITCTTRDFKPFDGISGFTDVENDRFKNSLDEYAPYDPEKDSFFHPIEVDNFTEYEYRAFLRFTINSGELAGLGWGPMWHYSSDFERKLYKIDFMSDRNPQRVINHYHQELVWRYEYKRTRQKQYLLARRKMWQGAEVSYGLHNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKD4</accession>
    <name>A0A088RKD4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_120700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009381">
        <property type="protein sequence ID" value="AIN96398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697051.1">
        <property type="nucleotide sequence ID" value="XM_010698749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKD4"/>
    <dbReference type="GeneID" id="22573076"/>
    <dbReference type="KEGG" id="lpan:LPMP_120700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_120011700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_120700"/>
    <dbReference type="eggNOG" id="KOG4308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052410">
        <property type="entry name" value="DRC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24107:SF2">
        <property type="entry name" value="NLR FAMILY CARD DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24107">
        <property type="entry name" value="YNEIN REGULATORY COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="250"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="798"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="702"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN96398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="843" mass="90852" checksum="0E4CDA762BF88987" modified="2014-11-26" version="1">MYASLGISSEQVYGDMYTAWLRDTHEKNTPDVKRLYTTTIENGFGDQKILLRRQRLGANFINSLAPLLHQCSLVKLDLHANVLRDVGCELLVHVLRDMPQLTHLDLGANAIGSSSIVTGSISGDSTAFKSKGTGGSIPTGTLASRPGGAVASGIAGGSGARSSSSYLNAMQALGSAIAQHKRLAVLILGSDREEAYVNQIEPIGAMLVLEGCVLSRTLKRLDLSGNPFAMNCGTPSAGAASGSVSPTGGAAAVTRVGSTSTPETDRAERKGGGSYGMRCAPRTPVQLLALLLRTSVALTHLTLRSVDLTDGGAAQLFEAAGASRTLQHLDLSSNGLSSRVAEMAGMLLRQRTTAVSGGALGCTLQSLVLAHNDLWDNSAAATQAHRGSLGIGAPTATEQTMCGGSRLDDRAQGTASVAPMPSASGSKYVSRTRALRDDVQDDTGVVFQLEHHSPPTLPPRDHSSGLVLLLALGHDRFITRLILDDCAMGDTVLSTLCRSLLTNAMLKVLSLRNNHLSPDGVVQLGRSLCRHPCLEKLLLSGNAIEDEGACAITTALDQPDASLEELDIAKTWLGDRGLIAIGVALQTNVSLRVLHVSDNHFTHNGGASFAALLESNNVVVRCELGATSVPHHIRLRVERTTARNRTRAENADADALKAEVVRLHYQKYKLLEAHLELAALRESNVEVKRTTENFDLQTKQDQSDLVKRIRELEEQIENAKQQEVRYTEQKAKLEADLAKAERAHEADMTYMAERLAVEVDLREKAEAELQQRQEELKGWQENGPEREAQRREQLAVLKADQEAWSSQRKGYRDRTTELQREVAALEAAESSKTSKKRKKSVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKS2</accession>
    <name>A0A088RKS2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_121030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009381">
        <property type="protein sequence ID" value="AIN96430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697083.1">
        <property type="nucleotide sequence ID" value="XM_010698781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKS2"/>
    <dbReference type="GeneID" id="22573109"/>
    <dbReference type="KEGG" id="lpan:LPMP_121030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200066600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_121030"/>
    <dbReference type="eggNOG" id="ENOG502S57M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="249326at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="439" mass="48346" checksum="7EA7E8686AEA23A2" modified="2014-11-26" version="1">MTSLRRDDPNTIPSSSSSENSPLGWARPNERLIDLLTRPRAHGGYGGRLSYAGFATLAASLGWNQEDIDDCWYDIVMGEPCAEAVDMARVAECVCSYCLASPLPMLERCTTVESIPAEPATPPRQVSLSTDRNTTVLLSPPTPPSRMAEAVALATLEKDKKERARTETKPPNLQTSSQRRRSLLNAFPRYAVETVSSEHRKTCVSPCHQSHKVQSERAATHSPRRASAAPATPRTSGASGSTVFLRLYEKGMEQHQKRTSARPADETAAECTFQPHITPYTTKAPDTRDVQYNRPTKSYFAKLTAQEAQQDLLHATPETPRVTYHPAPGPSSSVPTGYVEGVARLRSYIASRYTRRSFEGSLRASTSTDVARLMEAPILRLPITVGGVMDSVDVRLAPSDTRTSLGQRHNEGREHLSSRQPTGVRHASLLSPSRMRFEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLJ0</accession>
    <name>A0A088RLJ0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA/rRNA methyltransferase SpoU type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_140590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697293.1">
        <property type="nucleotide sequence ID" value="XM_010698991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLJ0"/>
    <dbReference type="GeneID" id="22573326"/>
    <dbReference type="KEGG" id="lpan:LPMP_140590"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140011100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_140590"/>
    <dbReference type="eggNOG" id="ENOG502S3JX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="262525at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002128">
        <property type="term" value="P:tRNA nucleoside ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004384">
        <property type="entry name" value="RNA_MeTrfase_TrmJ/LasT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42786">
        <property type="entry name" value="TRNA/RRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42786:SF6">
        <property type="entry name" value="TRNA_RRNA METHYLTRANSFERASE SPOU TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="149"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN96640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="524" mass="56311" checksum="A65A489EA324288B" modified="2014-11-26" version="1">MTGKKGWGAKTAWSMSFFEMVPWVAEDSVAREGTLTAAAPASSCASPHALPLSACDAASKAVGTSPSSSTPPPHSKPYKERKRQALDLRTRWRCRRCGMVLQPPLDAVTGKPRYGVMMTEHLEGVSSGGTTHLATGVVACTAGTMRYEKASDEEGALSPNQPSKRPRDDAGDDLTSGRVTEAESVIAGTGASHRHKEGGDDKAAAREALRRLLHQCQQGARQCGTANSSPLPLLFIVVENPKTPANAGGILRAMRCYGLHGPATAATTVAVSLPVATTQTATEEVTRSYASGGVWARATTPDAVESTEGSVRQRVGSFIFSGTRLQNAMAHSEYAHTLRTDPTHAGRDIPQLRVPTLDVLFDVLRGDYGHRQKEPRLPSPSLVSVVAVELVEGAIPLPFYEHPFGHLTRQETMQRARNGAAPREKDAAFTAASLPMVFYVFGAEDGTLSAHHLQHDVDDVVFIPTTGSMNLAATVNVLLYDRLAKECRRLHPAVADSTAAGMKWKDVFGARNANNRIRWTRSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLT4</accession>
    <name>A0A088RLT4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_160230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN96898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697551.1">
        <property type="nucleotide sequence ID" value="XM_010699249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLT4"/>
    <dbReference type="GeneID" id="22573600"/>
    <dbReference type="KEGG" id="lpan:LPMP_160230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160007000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_160230"/>
    <dbReference type="eggNOG" id="ENOG502SN58">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="261392at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="132" mass="14541" checksum="5D0FD345535D3B74" modified="2014-11-26" version="1">MEHALLQVVHLHPPKTLLRYDSAAHKEKLKLQPHPYAASSCEDCETVATDGQVAAYTDLLDFITGAQQECYALFGEDDTRWSVDDRAEEECSAGTLDSGSVRVNSSEWSEGDGDDAHGVSDAPRKRKRPHAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLW2</accession>
    <name>A0A088RLW2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">adenylate cyclase</fullName>
            <ecNumber evidence="6">4.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">ATP pyrophosphate-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Adenylyl cyclase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">LPMP_170090</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Could act as a receptor for an unknown ligand.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="6"/>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697700.1">
        <property type="nucleotide sequence ID" value="XM_010699398.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22573752"/>
    <dbReference type="KEGG" id="lpan:LPMP_170090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170005100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_170090"/>
    <dbReference type="eggNOG" id="KOG0618">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="260718at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000022">
        <property type="entry name" value="Receptor-type adenylate cyclase GRESAG 4, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050697">
        <property type="entry name" value="Adenylyl/Guanylyl_Cyclase_3/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057399">
        <property type="entry name" value="GRESAG4.1/3_peripasmic_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057398">
        <property type="entry name" value="GRESAG4.1/3_peripasmic_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43081:SF1">
        <property type="entry name" value="ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43081">
        <property type="entry name" value="ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25493">
        <property type="entry name" value="Peripla_BP_A-cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25495">
        <property type="entry name" value="Peripla_BP_A-cyclase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17 23" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15 23" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="891"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="22">
        <location>
            <begin position="931"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1279"/>
            <end position="1298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00032637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="AIN97047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1387" mass="149855" checksum="4288BD201C67E21B" modified="2014-11-26" version="1">MYIRPLHSGCRRCGGACDHATRLASQWRTAALLVTAAFTSVLLFSPPWVRAGITNAADLEPVYLLNTMYATDAFVEDDAKALWKGMDMAFYNSGYKAAGGRPIKILHPDPVQDSLNDTAAVILRALHRQEKLLAVLGPYMDTCLTAALNSVDVVKSELMLLGPFTGSSTVRTWSDSVYFTRAEPMIELKVVMMHVINTIRARRVAFMHLTGAHFGEEELLYMQLTLASLLRDPAAVYAAPLSAINAEVDQHAFDAMADTHPQVIIVWTAPGKQVARFLEKALTDSRTSSAYIISCSMMQRLMFHVHKRLLNSGSIVSRDGQILVSATGSPVSDQISKYIKVFKAQMRNYIENSGSFDYSPDDETVETLAPTLRSAMPRTRNFTVETFLEAHPDLAQLMVLGWLSGTLVQQTLERPDWIVSRSAYKAGLFNQNRFMIGGDYVLGDYGGSCEPLAQYLGATCYCNQGGRSAILTVLKDASWDILPDSLFTYPQSACNSSKAEVIKAATVLILMHLDSPKLMEAGVQMTAIAPDAVQDDSCKRQSVNRLSLSMTMAAAQRLFDAEVGNYSVDIVAGPMLRTLDVGNTFVVSPLYNRPHLLTKKRNYVYLMPTLEQQMFLLYFKIDAVRAAVSAGTDTRVTLRGYSADEADAISDLLCKTAGTFNLPDPFIIRVPLTESLAGIVAPKGINVVVGMTGGDGSRMATFLAANPAAIIVVCFDDLAMHYTELIAALSIQPSSVQSRLISFNSLPLWSDTSPAAEADSPVLKLFHRRFPDPRNHTPSLLRDLVTASFIEELIAKVGVPHKQLLAGELYMRSTFTTHNMVFGPFEWGCTTTASGDDCIYENYGAQSIVMLSVQRMLDPRVPPLTAPMTPSLVYRPRVASSALTPAERNGIIAGVVLLVVASIAAVGLLLYCCMDNRDNDAAPKDDDEPVTLVFTDIESSTALWAVLPQLMADAIVAHHRVIRQLIVKHGCYEVKTVGDSFMIACKSAHSAVRLACEIQTKLLGHDWGTVSIDAAYREFELARADADDDYVPPTARLSEEEYAAVWCGLRVRVGVHTGLCDIRYDEVTKGYDYYGDTPNMAARTEAIANGGQVVATETAWWALSNEERAGAAHTAMGRQGLRGVPFAVEMFQVDAVPGRRHAALRTEIEAILPDETATETASSAAGALLSSVGTMSGPAAGIALVLTSCFAPYPVAQRVRELQPLLSKWGVGAPPRSRAVSEEDYCQGLMNRLALRIATVSQARQRMGGKGGAVVAGDMPDVDAGGALNPLVGGGGCGAGGAAPRPSGMTAPPRSEEPSAMREWLALNCLKSDTQVSLMDSLSLRRASCVRSSIGLMDTVVPFSAHTSGGSTAENSGGDDEVATICITLGAPYARHVCDGASEEVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RM30</accession>
    <name>A0A088RM30_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">tRNA carboxymethyluridine synthase</fullName>
            <ecNumber evidence="15">2.3.1.311</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">LPMP_160250</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>uridine(34) in tRNA + acetyl-CoA + S-adenosyl-L-methionine + H2O = 5-(carboxymethyl)uridine(34) in tRNA + 5'-deoxyadenosine + L-methionine + CoA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:61020"/>
            <dbReference type="Rhea" id="RHEA-COMP:10407"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74882"/>
            <dbReference type="EC" id="2.3.1.311"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:61021"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ELP3 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.311" evidence="15"/>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN96900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697553.1">
        <property type="nucleotide sequence ID" value="XM_010699251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RM30"/>
    <dbReference type="GeneID" id="22573602"/>
    <dbReference type="KEGG" id="lpan:LPMP_160250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160007200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_160250"/>
    <dbReference type="eggNOG" id="KOG2535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10265243at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106261">
        <property type="term" value="F:tRNA uridine(34) acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.30.20:FF:000011">
        <property type="entry name" value="Elongator complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="entry name" value="tm_1862 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034687">
        <property type="entry name" value="ELP3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01211">
        <property type="entry name" value="ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF2">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01086">
        <property type="entry name" value="elongater_protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00344">
        <property type="entry name" value="ELP3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="14 19" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Elp3/MiaA/NifB-like radical SAM core" evidence="18">
        <location>
            <begin position="186"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="739"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AIN96900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="760" mass="84973" checksum="A4C565CF13F0C321" modified="2014-11-26" version="1">MSSEGDAEGEASSGPLSHVDWDRIEHKLTNLPTLERLLQESNPNDFTTADVEAAARFVRDIVATQPQCDADIERAQRRLQKAYRRVFKKSLLLAGYTQLLREAVTGANGTSIPAQPHQESIVFPGAPDSAAVLSDLEDAVPSVSSTPGTSPSPPEKTSVVCPVLERYLVFKAPRSQSGVLVVTVFTSAYPDGQNFSCQWNCYYCPNEPGQPRSYLLNEPGVRRANRLMFDPYRQFEERVRSLMAIGHPADKVELLVLGGTWESYPRQYRERFIRDLFYAANTMFDPPRAPRRPPLELLQEQLLNESAHCRIIGVTLETRPDTINPAMLVELRRFGCTRVQLGVQHTDDRILTLVNRQSTREDTANAIKLLKDSCFKVDIHLMPDLPGASSAIDKAMFDDVLDSPYLQADQWKIYPCQTTPFSVIEQWYKDGKYTPYGLENLIDVLLYAKARVHPWIRINRVIRDIPVDYILAGVEVANLRQLLACKLRERGERCRCIRCREIKGDKTVAERLKSAILQERRYEASEGTEVFLSVEMPTDDATILGFLRLRLNIRNWETPFAELLPCALIRELHVYGNLLPTYVEEAGRAHAPAAQHNGIGQRLLKRAEAIARTEGYSHIAVISGVGVRGYYRRCGYRLLAASRGGFLVKNLVDVGDALAGAPITASQVAPLEYSLERDEALLRRVAANRGASTSLVSGAVLPLGVATAATLLTHATAWCGKLRTSVTQWWSTRKRCREEEVEQWPPSGAEGHVKPTAQTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMF0</accession>
    <name>A0A088RMF0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha/beta-hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_180110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMCO4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697845.1">
        <property type="nucleotide sequence ID" value="XM_010699543.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22573901"/>
    <dbReference type="KEGG" id="lpan:LPMP_180110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180006200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_180110"/>
    <dbReference type="eggNOG" id="KOG2385">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277931at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007941">
        <property type="entry name" value="DUF726"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920:SF3">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05277">
        <property type="entry name" value="DUF726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN97192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1489" mass="162282" checksum="3DEC6F206E448151" modified="2014-11-26" version="1">MAAQTVLRNTYSLFDSYQYLWSPQRPQRTAEEIQRLCQSTDVPASEMPIFISLEDRVAIRSLLYAVVDDTSLRNLLDGVLLPPPYACPDLHHKRLTPKDVQAVCSVLNPSLDWVVVNLPFNLALRLGSYDARLRAAAQRLSWILSIPFSLVEREETTLAQLRMTVGRDIATEQADVAKQDGVRRSKEQQRRSLMRVATIGGFSVIGGAALAVTGGLAAPLVGPAYAALVTATATSLGAIGAVGSAVLGTGVFATVVGAATHATALASLVTPVLTTANITAIFGVTGASLSGYKAFRRTTDSDIFMLRSVDDAEAFETAASSTAEVVATAAEEEADVNEEVVSLLACSHPLVESGSGGTGTSWDLSDVFEDDLNPGVVVPLHTRMFAMSHTRNLPSLQKRHRHVVFAVENKLDGLQLRLKAVKLISGVWAMAPPAVVVPGHAGIFACVNRFAHPTGAGFIVCYVATPSSSTGKATPLRIWVRAERDFFGAWALSAACEKDELDFDPTVAENWLRDHLTCSDFTRRQQGVALELHVAPYTYLKVYPASTGDKPQSRKVTFPKEELPQRQLEYWHAVNQRRKLGVSLVNRSSHDVLTRDMSIIHGQQWPETASPMGVYPAEASLTYFTSREWSLAGAEGYYIVEVVNSYTNPVTPRFYVRVQFEVSSLNNVNVAFASAYNLSELRHQSLTPCAPCSPQFPVDLPPGLFFSLTCVIDVALYTVQLVFQDLVEGCGTAGVLAMERTTLVIGVSGYSAIFDPRRPMRDQQVGLWQSVLHRCALFGSMEPYVLQWEDNYLMRFGETIQVNLDIADKVARKAVGMTAKTLLQGSMFSSLHAFWSLMGTFQLPLFAVWATGVIDNTFATLSNRSAYTGKDLAAALLDQHRGNRPVTLVGFSFGSRVIVECLQELDKVEAYGVVENVYLMGCPCSSDPRLWRGLRRVVGGRLINVYTREDWTLWMMYRLNETELKPMAGISPVNVPGVENVDVTPLVSAHGDYAVKLLPVLNAIPQQPTVASWSPRENCGSPGATVPVRKCSETMAAVSKSLHSYMTPTTYVALGVKNCVVSDIPHYEPQVELLTMQLYGCFFDFVPPLLTYSGMASVAGLLGDTEHAMGAVLAYRMRPPASAPGDLLVVLYLCRSGDGDVQVCMQPSLVERRSSAAETEGQAYQRLCAITAGACQTLDDVQRMCHTNGVEWGLRGGAAHMQSISVLVPNVFSDTHRTATLRLALERLDSAEVTVTWLALLNKASTQLQQETFDETEFKNAMAGLATLRPNLLGGGNRMQLPVVGETCSTDNLQQRLRFLAAQLQDPDKYPSNTRPYVLLNCGTSPLYFSETFYKAAITSQVANDDAMPDMPSCGRMMPQWLCFPPPEIPPNSFTVVLLTAHGGGASMYPVVPLVRYETDKGQCAFDVGFSVSSDSSQEGAHPEGAAHCHPVVGRPYIGGAAFFGTTIQTTPFAIITMLPRSSTEASAPVEDIHDTVGSRLRKHGWYIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMK0</accession>
    <name>A0A088RMK0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospholipid acyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_170900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697781.1">
        <property type="nucleotide sequence ID" value="XM_010699479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMK0"/>
    <dbReference type="GeneID" id="22573833"/>
    <dbReference type="KEGG" id="lpan:LPMP_170900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170014900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_170900"/>
    <dbReference type="eggNOG" id="KOG1505">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="186786at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF16">
        <property type="entry name" value="LYSOCARDIOLIPIN ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="2">
        <location>
            <begin position="127"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="477" mass="54612" checksum="101A50C3CBC06CB1" modified="2014-11-26" version="1">MKLTLVGSIALTCALVVAVFAFSLYESWLVLVLYLVKYVFGDSALMPLYRLIKVHYNFLQRAYLCWVDCLLENMLGTRVAYTVVDSDGQEHLEQHYITTMRNEEGAMERYLDLDKVLRPPSQPGKVKIIIMNHHCRIDWVYTFLYFARTRRIISHIRYVMKGDLKQLPILGWCMELFRYLFLARNWESDKVHIQRMVDFYNATNDTPVIVIFPEGTDLSPSNVQLSQAYAAKAGLPKFHHVLNPRTTGTVALMNMLGGADKVEEVVDLTIAYTLHASGERPNEASLVNGHHPKKVHLLINSYPVAGTAAAAAQKKPTHVCPTEEVALTAWIHERFAEKELLLSRFLLSSPIGFDTADVRAVLGEGVGVAGYDDDEERLRHPNRPWWRRYYQQVGLFGAVITPVYWLAPPLYCAFFIRWWLMMLWISAMLLAFTMGFKAAGGLQESLYLKVVAPEATLMQQLRRMLGRRQMRMDKKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMR5</accession>
    <name>A0A088RMR5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_170870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697778.1">
        <property type="nucleotide sequence ID" value="XM_010699476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMR5"/>
    <dbReference type="GeneID" id="22573830"/>
    <dbReference type="KEGG" id="lpan:LPMP_170870"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170014600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_170870"/>
    <dbReference type="eggNOG" id="ENOG502S9NW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272324at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="534"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="559" mass="61395" checksum="022B0A5E8017B7C1" modified="2014-11-26" version="1">MATPRCKKDGGAPSSGTNGAVEVFVAETSDIRDLLYKYRAEEELLRSDLRSFVHREIDEQATFSHLRASVNQSELSSLRDPRFIEYIARFQAEEKAVAPSAVSTGDPMTTACTVSVGATGARANCQWWAPRMKEKGSPWLRCWTPDAALPLAAFKSLSDVWKGWRRVSPAYDAAFNRMLEEVYSTAPSSCTDSVRYCCFGNGTLCVFPIEEDMAMMDGFEVRVTQMPQSSSEPVPNAPSLLSVDNAGYVVAAALDHYFTELTSAVAMTCDDLRTKVVALLHKKKPDSADVHATVADHFRLTGDAWDTLTFVRPGRLQHTVMVRGFFFKGRLALVEQLGAEVDVVPLFFADEKGSDMLEEGRRRVQRLFSQTLATLYSELGQACNGVEMLGEAALPPNAALTAAVMVPSSERDVVSGVLLDVRPVTPQLSFDRRVTWMDVCAVGRQRSGATRGAHEPLDAAGVSRGRSDEEDSVLFRLTHLPVASLQAYDSVSRRVFPLLNRQLTADQRHKHEMTEEGVEVPVRGVLDISSATAMTLPICVGAVACVVVALCVARWVRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMW7</accession>
    <name>A0A088RMW7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_180720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697906.1">
        <property type="nucleotide sequence ID" value="XM_010699604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMW7"/>
    <dbReference type="GeneID" id="22573962"/>
    <dbReference type="KEGG" id="lpan:LPMP_180720"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180010100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_180720"/>
    <dbReference type="eggNOG" id="ENOG502QUMB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273519at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="691"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="851" mass="92123" checksum="B0073391CBFAF497" modified="2014-11-26" version="1">MVTRASSGSGDQGSLSPVEQLVDKQEQAYRTLRATIAASCALGHRSCQVLWGPRGSGKHRILRLLAHDVRRTPNTFVMELHGRLLKDDEAALGVIAQQLLSFLQSPQSVQLRAEHYLLRTGTFGFGQLFHFERHMRDDGVATAVVAAPGHSVRAIVGADALFTHAFHHLAGDGGRNGPNRRQRPSTTTNPLAKTPHRGARRTRWHSSRRASGSLADSDADMSGEDAEEYGSGDEDDVQGSSVMVTSTTTYLTGGAASALPHLQRALLLLKSHGCSIVVCIRDIDVFGVRCDQLLYVLSGLMHDNDGGSGGGGAGSGGGMSLVLASAAPDIRQLEKRLSSRLTCEARYVPLLPWSLRNLLAATLHTMVQDASSQVRMREVERQRAELVAALSVEATKLRSRTDGVGKLQGREQELLKKLMADLEAQLHASDATLRELRGQRRHLSSLFDLEGTPMTARVGANEAGALTQGHYSAPGWRSSELPPTQQQRASGSASLTSPSFTTARTWSVSSLLAHSSLTLEVQCVMCEELLRQLCCATHARQARGLVGVDAVHGSCRSSLASLVTELSTELEQNSSTSSTVMAVLANHLCKAVSGAIDLLGESGRRVLLRWLRARLQHEPIPPASVSAAPAEQASTACPAGVSPMILLSWREAAQCMVLHTSDCRTGLFEEAAENECCARVRLRPPFAFGNSKPAEMDGANGSRAEYHRPGSELPPLSLLPPHLHDLLADGQLVGMGYGSREALLVLFYMHVHHTSGLQERTVADLLEDVSSSLGTTAAAALDREAFRHAIRLLCRWRLLRVVEAHSQLLEICGSDARLREFLMTVLSKQPEWCETELGLDAREIVRFRSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNA0</accession>
    <name>A0A088RNA0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_190750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698071.1">
        <property type="nucleotide sequence ID" value="XM_010699769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNA0"/>
    <dbReference type="GeneID" id="22574129"/>
    <dbReference type="KEGG" id="lpan:LPMP_190750"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000036500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_190750"/>
    <dbReference type="eggNOG" id="ENOG502RI9F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276603at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="252" mass="29199" checksum="B947B4C1666B0C99" modified="2014-11-26" version="1">MELGQTQRPRAPAEPFKDYEPRHKCTVCCGLRCAAFTGSATFCFSLVCNAFVLGGRVTDGHGWRGFLNRNSLIALPVAAITFTHQVLLSESLWSKNKKTVAQVNTQSTLSNMSLWGLGTALCTTVSRRYLPARSRAYRLALWEYHRTRRGCANPWMPTVFGRVTGDLDWYNVMWTLTLYHLLWGMVSVMLEKEVGAHYAMFYRNGQYSRRCSPRWREWREVEVRRHVDTEQAVAPNRWGTFITNDKWRTRNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNB9</accession>
    <name>A0A088RNB9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_190960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698091.1">
        <property type="nucleotide sequence ID" value="XM_010699789.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22574150"/>
    <dbReference type="KEGG" id="lpan:LPMP_190960"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190017400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_190960"/>
    <dbReference type="eggNOG" id="ENOG502SGTD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267458at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="106"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="220"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="411"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="459"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="584"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="719"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="941"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1064"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1134"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1247"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="672"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="421"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="521"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="740"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="951"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1075"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1279"/>
            <end position="1295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1314" mass="139130" checksum="0B8374BBC62A3A72" modified="2014-11-26" version="1">MNDYDELYEDDFENDEIASAAGKSFSSHVASMTTPHFSSSAIHGTASNGGVATATAVGFGGVAAKKSGVMNPPPRPTCSLDSSFSSYQSSSSDLLLPSAHELCSSSSWHSSTSSSRHHSPATRPAKDCGSTRRAAGSRKGRRAFATAGSPNAVVLASGYFRTVASPKDPNAVTLTSARPFIPQAPEQHEITSSAQDAYAELHADDRVQVVVSGAGKQTQWIPTPETSTTNAEAISCTSPHSTSSTSSLPGRARSSHRHEPSAKSNSVSAIGAKLPQHATAVAHASRSSSPLSSSTDDDDDTGDCGQRHNTFSFPFATAAAPAAAVAAGIVTAVTRNVSAERNHSCSDSAALHSGKKLLHQSNYTSLDVLVSNDGHGHRRTPAEIDAAAAAVDDEEEGKVDHNNLGASATVPSEAAARRQRMTSSPSGCSSDSFTSPTPSALVGPSLTNRQRTQWHNAAIASSSSMSPTPRTSLKRTSLLGRSDSIGTATGSVMPPQQQPPSLPRIHTGAVPPDFRTDHSSSRQSDSAASMKLRASGSHSTSSMSALSAASLKMLAAGNDAVRSVSQRRQVSGAASKTIDARLFNGVYDPQSPRTASGEGDDSNSHVEKMPRSNMTAKQPPPPSLPRLNSSQTSATTSRGLPFAKMVVAKTKGYTKTSTAAAEDDDPPEPDERMALRARVAQLQEDIAMWDRRIEQQRALMKVGAGKLGNAAVSSLQRHSADAAGAVRRRTGFNGGKQRSESVQNASPKQTDAKGGRRSVNTRLAKLRQENEHLEAQYARQGAGTAGMCVQTFVVRADVQLQKVRQQLKEVTAARRALENRDKRAAHTIKEVHRRMPTADELEERQLKEGIYSRTSLLRTVKELKANIKRTRAATKLMEVKCGELDAHVRHRRLSSITPKEYEALCASRDANAKTMERHKTAISVYAAAFAQGARSCSKSAASGFGAGGGATQSSRSSRTTSPRASSVSPARVGVTEREQKQVLAEYEVTKADLLLQQKRALHDRKQELQASIDELWLRIQKRNEQIKANHAVAGLNYVDTSSVAAAHESLYVVGNTGPKRLTPASTSPMPGQGCGSPASGSSAAAVRKGSLRDLLRPSLKQRTEATTAAEGAKGGVDATRERLCGVVAGERKRGQENANANALHRGSKPLPALTQTGNRIAAGDEIPVSAAAAGTTPSRPSRLALSCDTIEDEDAAHGSIEAILQKIDADNRQLCQGVFEQGRREGAAPPRLWQVFDNTDAVKAADSVHSDTGGYTGGMSQCDPATSRAARPHGVYDEEKIDEAPMEEEVIEEELDAGKSDGSGRSTPEWLREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RP46</accession>
    <name>A0A088RP46_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coiled-coil domain-containing protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_202040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698405.1">
        <property type="nucleotide sequence ID" value="XM_010700103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RP46"/>
    <dbReference type="GeneID" id="22574413"/>
    <dbReference type="KEGG" id="lpan:LPMP_202040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200025800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_202040"/>
    <dbReference type="eggNOG" id="ENOG502S3SN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="78858at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="258"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="48"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="47465" checksum="35CBEA2C9999749E" modified="2014-11-26" version="1">MPTVAASRSDALAPVHEMTMERLRREYVSLKSTSYSLTVEESHLMCKIETLREESVRAALNAEMMEEQVSNQLFRRLDGAEKEVQHYQSLLKEEESETESLSKRIKEMRSQQTEVENMLEERQEYLLMNLQRKLLDMARKKTEVEQELMAERQKYLDVLVTRLNMLRGRGPGSSTESSVTTHSHLSPSEANVASVEKHVDVTLPTTTASHTPTLPLRVGTSLGDGNSMPSAEKPLQEDACPGTTLPLPLVLTPSLTAQKRPNDGFSESTLLSNANVPSGRFSMSTTPRSADLTPRSSHSSEAHHAVVALERKLNQLLLDQAVAMQRTSATEKQCAELTAKLHAVQEATFLDRARAAKMKEELEKARARLSEMKATDSCGTPFSSIDDGFATSSSSVSFENSSFVALSNLSLRERTRELLSSVPPPNMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPE3</accession>
    <name>A0A088RPE3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phospholipase A2-like protein, putative</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_203330</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PLPL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698535.1">
        <property type="nucleotide sequence ID" value="XM_010700233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPE3"/>
    <dbReference type="GeneID" id="22574544"/>
    <dbReference type="KEGG" id="lpan:LPMP_203330"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200039700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_203330"/>
    <dbReference type="eggNOG" id="KOG2214">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10049244at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021771">
        <property type="entry name" value="Triacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF66">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE PTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11815">
        <property type="entry name" value="DUF3336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="463"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="7">
        <location>
            <begin position="190"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN97828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="570" mass="63329" checksum="B3BF8333A8F91755" modified="2014-11-26" version="1">MDSTLHAFRVHGAALYHWTSYVAYVIYSCLFFACEVIAGVLEIPTNAPQYDALTHQANCTTSYEEWLPIASTLDDMDGFQKWRTDEASTYFSFEGVMRTIEELLELRTAGSAEALLDDLQKHVHRSLYGISHRRLYSYRTGSKTVIHSYNSLVCFLLSRVGEAARTDRRLAVRTREVFSEMYHVYGTTALLLQGGVLASSAHFGVAKALYDAGLLPAVLYGSGSGALVATLVCCCTDLTSLFHHSGGGSSFVEAHALFGMSTADSRWKHFHRLLHTGEVCDPVALADFLQRTIGDVTFAEAYAQTGRVLNIPFVAVSPVLPRRKADVDVQLLNYLTSPDVLIRSAVICAIFSPSTLLPVSSSSCGLSAGAAPPTRTLLARTRLTGTIVAYEPPVVHESYSCSWGDHAGYGALDPVQRMRGLFCIRFCVVSDASVRGYLWQLLHQSAYGDGLRHHTRMWDWARYLFALYFLGLAHVLLHLLAWIGYNAIAAPSPTSMRTFFEDDESENVRVHPISRVWSYLRLCYSPTTANMQVLVLEAERQVWPRLEQLRMSISVEQALAATLKRLPVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQB0</accession>
    <name>A0A088RQB0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thiol ester dehydrase-isomerase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_210530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698840.1">
        <property type="nucleotide sequence ID" value="XM_010700538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQB0"/>
    <dbReference type="GeneID" id="22574875"/>
    <dbReference type="KEGG" id="lpan:LPMP_210530"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210009800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_210530"/>
    <dbReference type="eggNOG" id="ENOG502S4W6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="46529at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="209" mass="23334" checksum="13DF2D0893A34424" modified="2014-11-26" version="1">MASLLARQALWVPVVKHNPTFVEQVHKFLQISPITSLTAAAIGLKLEEVRVALEPDARHSDKMVASMMAFPVQISGAACDSVLEQQQRRELSFGFATSMCDSCNTIHLIERLLPASHSHVSVSIQSNCMRNLREGEKLLVVSTIDKMGKRLVYCKTDFFVEVTEPVPEEVVQRERNIKTLAELRAALMHYEKAVSGAHVKLIIAERKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQF3</accession>
    <name>A0A088RQF3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4833 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_210930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698880.1">
        <property type="nucleotide sequence ID" value="XM_010700578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQF3"/>
    <dbReference type="GeneID" id="22574915"/>
    <dbReference type="KEGG" id="lpan:LPMP_210930"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210013300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_210930"/>
    <dbReference type="eggNOG" id="ENOG502SIQ7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="88626at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032269">
        <property type="entry name" value="DUF4833"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16117">
        <property type="entry name" value="DUF4833"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4833" evidence="2">
        <location>
            <begin position="79"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4833" evidence="2">
        <location>
            <begin position="256"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="313" mass="34674" checksum="23A662813A296235" modified="2014-11-26" version="1">MSSCPALLFHSCVWEPYSLSIKGQLITSAIETQNNANADADTGVLLSPRAYVQQLNSTIRRHLAPRSRFKCDHHDTCMYIERSKNENIVAYQANLIDSKTGEPVKSGAHQSCCSFNTADPLHAYWIKINSEHVARRRARGELEDTCELNTIERKLAYGCTASVVSKEKFLSEVLLDKALRAAASREKIEAIEHLCEEVQPCLCKFVALSSWSVWMLRLPPLVEGADATANVAPNTDKEASPLPRGGDEGQALPMRDTVVVMVAVIAGQLSVLQKVYVESIEPKHFYQLPKVAYIEVHGTSLTTGEPTYEKLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQI5</accession>
    <name>A0A088RQI5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Major vault protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LPMP_210240</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The vault ribonucleoprotein particle is a huge (400 A x 670 A) cage structure of 12.9 MDa. It consists of a dimer of half-vaults, with each half-vault comprising 39 identical major vault protein (MVP) chains, PARP4 and one or more vault RNAs (vRNAs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698812.1">
        <property type="nucleotide sequence ID" value="XM_010700510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQI5"/>
    <dbReference type="GeneID" id="22574846"/>
    <dbReference type="KEGG" id="lpan:LPMP_210240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210007100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_210240"/>
    <dbReference type="eggNOG" id="ENOG502RPZD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6125719at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08825">
        <property type="entry name" value="MVP_shoulder"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.560:FF:000001">
        <property type="entry name" value="major vault protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.570:FF:000001">
        <property type="entry name" value="major vault protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000010">
        <property type="entry name" value="major vault protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.550:FF:000004">
        <property type="entry name" value="Major vault protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.560">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.570">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.550">
        <property type="entry name" value="Major Vault Protein repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039059">
        <property type="entry name" value="MVP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041139">
        <property type="entry name" value="MVP_rep_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043023">
        <property type="entry name" value="MVP_rep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021870">
        <property type="entry name" value="MVP_shoulder"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043179">
        <property type="entry name" value="Vault_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040989">
        <property type="entry name" value="Vault_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041136">
        <property type="entry name" value="Vault_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002499">
        <property type="entry name" value="Vault_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14165">
        <property type="entry name" value="MAJOR VAULT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14165:SF13">
        <property type="entry name" value="VAULT PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11978">
        <property type="entry name" value="MVP_shoulder"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01505">
        <property type="entry name" value="Vault"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17795">
        <property type="entry name" value="Vault_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17796">
        <property type="entry name" value="Vault_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51224">
        <property type="entry name" value="MVP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 10" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Major vault protein repeat" evidence="12">
        <location>
            <begin position="171"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="repeat" description="MVP" evidence="10">
        <location>
            <begin position="173"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="MVP" evidence="10">
        <location>
            <begin position="231"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="12">
        <location>
            <begin position="387"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="repeat" description="MVP" evidence="10">
        <location>
            <begin position="390"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="15">
        <location>
            <begin position="439"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="14">
        <location>
            <begin position="586"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein shoulder" evidence="13">
        <location>
            <begin position="648"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AIN98105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="990" mass="108845" checksum="14346EDC26CAE137" modified="2014-11-26" version="1">MVAESGGLSPAWRHRWKNRRTNMSAAPDDKKAKAMSGTSVVKLMPHEYLHVEDTNTCEVLTLVGPITYTLYDHHRKLHKTPQPCVVVPPRHFVKVKNPMHAVLASFTDNADAPPAHTLLRSSPGSITGLATLRYSRWKMPYGSSELRFSNESPFPLLPDETIDEPSVMPLLTASEALTLEALAPHDVTDPVTGTTVRRAAQECFLFKGPGLYTPRLDERIVSKVTGVRVSPLQVCYVSAKYDFVDDDGVPRVAGEQWVVQAHGIFFAHPAVTLEMRDAYVLASTEALTFISYKAFYDEKLQVAREAQKPYLISYADTKDGIYLPRPHETFQGRRKQVHLSATQYCVVINPVGADGTARLQQAEVRVGKQSFMLQPGEFCTQPLTALVLREDEALLHIALQTYTEADGTVREGGSRWLVYGPRQYIPPVYARVVERRHIIMINENCGVYVRNIHTGQVRSVFGKPFMLSADDQLWERPISAYMRRLLSEPRQSLRVTDMSMKERAEASLAEGWATTRMERNEPSSSTAAVEVAGGGCYSSSSSGESLDSYDDFMGRNEYVNELQLLSTAARNAHPPRLSRDLRRYHVITANMEHNTLVRLYDTSTGLSRVVVGPATVFLEPHEHFTPLSLSGGHPKEPHQIHSLCLYLGPDYMADIIEVETRDHARLRLHLAYNWEFGAVASNGKASGVDPELAFAIPDFIGEACKALASRVRSAIAGQTFEFFHCNSSTLIRQAIFTPAADGSIVSHGDSLCFTANGLYITTVDVQSVEPVDIKTRTALVKSVQLAVEIITKAQESDASHQAALLEQEAKGALDLQVVHDRAKAEQQRTELLRVIGGNTALEQAGASRAQALAESAARLVEARGEADATPIRCAAHSVGIDAELEVLRKRAELDLAHRQSMNDLAIDKIRKLCDIEATKYEKIMASLGKETLIAIASAGPELKAQLLGELGLRGFVVTDGKTPINMLNLADRMAAEPASIAPSPGTLGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRM4</accession>
    <name>A0A088RRM4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_231000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699257.1">
        <property type="nucleotide sequence ID" value="XM_010700955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRM4"/>
    <dbReference type="GeneID" id="22575305"/>
    <dbReference type="KEGG" id="lpan:LPMP_231000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230016700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_231000"/>
    <dbReference type="eggNOG" id="ENOG502SM4X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="263809at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839055" evidence="2">
        <location>
            <begin position="41"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="473"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="512" mass="54451" checksum="3D35A37F11E08890" modified="2014-11-26" version="1">MKMHPRAGWSCAVQPPQSSLLQLLALVLMCLCTHITFVKAAIVDTSVWLNAPAPVWQTIISTPEGEYAIKAMAQIDFTTAVKSIDISASVTVKALTPYVSPASGPAYGAGISFSVTTESLTDSQVLSAVRSSALPSINHFFATSASLVVLVKALGADGPSAMVSVGQMLLPVTGSTFFWQVLLDTLATGGSATPSVFMMPLQIDVQDAVDVTVQSYLVEMTPPTNQVNASSLYVSYAVWAFPGTEVGPSASSDLEELVRKSTLPEFNNYMSTLKDTYPGLQAYSDLFPTEVRFWTPPSGNPFDPDSTNPNADLPALANDTGDYFLLFRGDAGTWGQVWERNRLAVSASIESAIEKRLHRRSFVNHVSVISAKTVTSDLEHIAGLQVLCRVVQGITRISSHLWSPEEMASLLLQGDYSVTQALYYSGGSVPPEGLMQPHAAAVQLIPLAAVQDTPGTLATTRVSYDYSVTLSKAVVGIISMAAAIVGISLVVIIIAVGLSFCPQYIGGGTNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RS44</accession>
    <name>A0A088RS44_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_205680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN98059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698766.1">
        <property type="nucleotide sequence ID" value="XM_010700464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RS44"/>
    <dbReference type="GeneID" id="22574780"/>
    <dbReference type="KEGG" id="lpan:LPMP_205680"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200064000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_205680"/>
    <dbReference type="eggNOG" id="ENOG502RXE0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19232at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="881"/>
            <end position="921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="975" mass="104797" checksum="BD06B7FED527CB41" modified="2014-11-26" version="1">MGAVNSCICLGAKKYRFKDLIVSVYPDDIHGGPDADALAKLNSYTSSNPESIPRVCRKIGKLLRVHLAKKKESRVMVSVLMLRSLIEHSAHVNDFVPHSVDICALLLSTNVSRYHVGAADVLSTLCYQLSTQPDTDSARRLMADNKDRLVPQLLKMTHDHIALWKDARAVQTRYAAILALGNIANCIHIALAGNAAVIMQAMIVNLILVLRECVQEPLSDSWVRLLAKQHYGSSDATWAASPIVQLPVETEEQDVVYALACGRGIGATAACTTTAGVGELLNRVTALLEKQDGWGIPYVPSLVFSDIVSAMQRRPQQLGFSVYQCLCDVGQRTSDPSVRIGVLRSLQTCVDVLPMTGGRPTVVLDRIMSIMQLFMAGSTADGADAADEGSVESARLTKETHNAVVILIGRLLRSTYRQHNASQLQSILISLRHLLETAQSSGTPHPTLALRLLVVAAPYLRSVPLVDRRDMRVTNVLELYLNGGGDDVQRRLASRVLTGILAGIPVQRHGAVGNGDGDRANAAALTAAFSATSSSPVDTETLLTNEEDVAFAQEWVKRVSRETEGITPLTVVSVADVLCALMAGYGVSGLPFTLAFLWTLQRRCVRAEPASAAAAAGPTLAAAQQDDSTNASTVAATTMSASRTATSPLTRAWLHMIAALLVCCGRVYAIPKLHLYGQEILEKRAAAGQLASCFEPALRVAGHATDMYTISGLRYLVSEKSRPLATDFTEAPVSKLPSFSYVSNIIVDADWPEVAVVFGASEEEELHVVIEEVCFQPESEINVSLIRVIDARNASMSTTDATSPRSCHFSLNVQDEAKVSTLRSLRISVADNSIPHTQDSRGEVPFSAAATTTAKKVQEIAKHYNVSAETQVLQPETMATLPPLPMLPLPRDGEDTSGGMSESSEPASEVRGKAKPPPLYAAGFTTENRFRSGAGMDSAAWVNPLNVDVGIQAARKVQTVLSIRALPAGRYVSMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RS47</accession>
    <name>A0A088RS47_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_241560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699495.1">
        <property type="nucleotide sequence ID" value="XM_010701193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RS47"/>
    <dbReference type="GeneID" id="22575565"/>
    <dbReference type="KEGG" id="lpan:LPMP_241560"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240022700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_241560"/>
    <dbReference type="eggNOG" id="ENOG502S83J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="252797at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="559" mass="59874" checksum="82D88BE816A4AB21" modified="2014-11-26" version="1">MDAAIVRLRGCLGELLSYYPHVLRNVFEPEPSLLGAPEPSQQQLQDPSAVADIIEGFLTELTRVLSIGIRDDNLGLWSVLELLECVPDRMQAVAEATAAATQTAVLGEDRTRGPLQELQRFRFASQLVYVVRSTFPAASHALRTRILLRLTLNQGCLLAALELLREWCRQELLAFYAASDRGCSNSVVGSVPSEALLVQPDSGSDVWNSFVAAIAPVAGPPVAEIAAGAPKLAAQPFHLQLLVSGLDDSSAASRAYYTQVQSYVYGRRPTRPSALVCYRAALQKQSNIVRKDDDSARSPSKSEDAVFSPQISPHPAEQFALRVESLPVDCRTASSKAAAPVPKGNMSYGSSSTLSSLLITQGSSSSVRDGRVRGTKKRRRRRPSLHTTDSEAAVHAEDAAVPPMLLADKTGNSTSDNTCSVEETAVNSSTVVADVRKCQDAPEAVEEVAASYTQDDVLQKADPQVIPAADETGVTEAASKALDTASIDLPAAAFSNLSPALCASKLPSMNLDSSSAPAPSSELTDLRHSLWLCWFAVMTHAESVERSRIILHDVDANTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSG3</accession>
    <name>A0A088RSG3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerophosphodiester phosphodiesterase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_242130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699552.1">
        <property type="nucleotide sequence ID" value="XM_010701250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSG3"/>
    <dbReference type="GeneID" id="22575622"/>
    <dbReference type="KEGG" id="lpan:LPMP_242130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240028600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_242130"/>
    <dbReference type="eggNOG" id="KOG2258">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="197419at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008889">
        <property type="term" value="F:glycerophosphodiester phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006580">
        <property type="term" value="P:ethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070291">
        <property type="term" value="P:N-acylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000067">
        <property type="entry name" value="Glycerophosphoryl diester phosphodiesterase family, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46320">
        <property type="entry name" value="GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46320:SF1">
        <property type="entry name" value="GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012587868" evidence="1">
        <location>
            <begin position="16"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="2">
        <location>
            <begin position="35"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="334" mass="38659" checksum="FA0CE7B40A5C641E" modified="2014-11-26" version="1">MKFALLLSGVGAALGWSYLRHIQLPAGPSRLPWSGVVFGHRGCRGVTGIPENTLEAFRYAAAHGCGGIECDARLTKDNEVVLFHDAFASGHLRGVPPMRRIDELTLFELRQCRFMADPTEKIRVPTLEEAILFCRDNNMRMLIEVKELKRAYLCTDKVLDLYRRYSDYMHDQTTLISFHSGILYHARRVDKKVAVCQLYSTNVVHSWLSQNIDTLPWVLRLCPALWNRVLPFVQERLMPWVAGCSMVGPHYGLFTELSRRRWVTRNICMYLWGFERAEQCTPAMRQPGVCISGDDHYECFVTPKPPPDYDIFGDRQRELEREQEEAYKRLRIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RT46</accession>
    <name>A0A088RT46_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flagellar attachment zone protein 1 conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_261950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700014.1">
        <property type="nucleotide sequence ID" value="XM_010701712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RT46"/>
    <dbReference type="GeneID" id="22576098"/>
    <dbReference type="KEGG" id="lpan:LPMP_261950"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260024200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_261950"/>
    <dbReference type="eggNOG" id="ENOG502S9BC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268046at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056614">
        <property type="entry name" value="FAZ1_cons"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23398">
        <property type="entry name" value="FAZ1_cons"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flagellar attachment zone protein 1 conserved" evidence="2">
        <location>
            <begin position="49"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="226" mass="25399" checksum="832913F19DB962A8" modified="2014-11-26" version="1">MPSSVYNDHSESRENVDVFSNGESGDRIIDGLRYPRPGRHIDQLGFEMTTHGLHFHGSDWDIPLAKRRDELTKSFMQDAMEATGEPEENIRNLRFIVTPTHLDAKLTVRHKIEVSKSAVHRMLTSAKWAHVKGLYEPRQKMRRPKDPAMAHARHGGAHEGQPMLGTNRRTPSHNLSFFGRANVGANGPEFEDHADDGEEPAAYENQQNAKAERTTSGLYIAVGLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RT47</accession>
    <name>A0A088RT47_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Centrin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_221290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699131.1">
        <property type="nucleotide sequence ID" value="XM_010700829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RT47"/>
    <dbReference type="GeneID" id="22575175"/>
    <dbReference type="KEGG" id="lpan:LPMP_221290"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220016600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_221290"/>
    <dbReference type="eggNOG" id="KOG0028">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000331">
        <property type="entry name" value="Ca2+-binding EF-hand protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000340">
        <property type="entry name" value="Centrin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050145">
        <property type="entry name" value="Centrin_CML-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23050">
        <property type="entry name" value="CALCIUM BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="4"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="78"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="114"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN98424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="149" mass="16498" checksum="181988AC5A4CE603" modified="2014-11-26" version="1">MAALTDEQIREAFNLFDADGSGAIDAEEMALAMKGLGFGDLPRDEVERIIRTMHTDANGLVEYGAFEVMIKSRMAQKDSPEEILKAFQLFDLDKKGKISFANLKEVAKLLGENPGDDVLKEMIAEADEDGDGEVSFEEFKSVMLQMRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTA3</accession>
    <name>A0A088RTA3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA splicing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_260740</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699895.1">
        <property type="nucleotide sequence ID" value="XM_010701593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTA3"/>
    <dbReference type="GeneID" id="22575977"/>
    <dbReference type="KEGG" id="lpan:LPMP_260740"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260012200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_260740"/>
    <dbReference type="eggNOG" id="KOG0126">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2573941at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001088">
        <property type="entry name" value="RNA-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051847">
        <property type="entry name" value="RNA_proc/Spliceosome_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880:SF1">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="37"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN99188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="163" mass="18704" checksum="31353A1936A1B2E5" modified="2014-11-26" version="1">MRKYRSGNSGPYTTEYHALLGNAQWIVIRRLLRPPLKDVSDDGITPQLSEGDIVTVFSQFGEIVDVRFVRHRKTGRFLGTAFVKFKDYRSGILAADELNSNYEKGEHFFLSASQEITTSYSEQKGITVERCEEVVVPQLYNTEVETYAEWLCRHNVGLSVRYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTR7</accession>
    <name>A0A088RTR7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Deoxyhypusine hydroxylase</fullName>
            <shortName evidence="10">DOHH</shortName>
            <ecNumber evidence="10">1.14.99.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Deoxyhypusine dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Deoxyhypusine monooxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_261880</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-hypusine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:14101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="Rhea" id="RHEA-COMP:12592"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="ChEBI" id="CHEBI:91175"/>
            <dbReference type="EC" id="1.14.99.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="10">Binds 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the deoxyhypusine hydroxylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.29" evidence="10"/>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700007.1">
        <property type="nucleotide sequence ID" value="XM_010701705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTR7"/>
    <dbReference type="GeneID" id="22576091"/>
    <dbReference type="KEGG" id="lpan:LPMP_261880"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260023400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_261880"/>
    <dbReference type="eggNOG" id="KOG0567">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="421002at2759"/>
    <dbReference type="UniPathway" id="UPA00354"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019135">
        <property type="term" value="F:deoxyhypusine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000726">
        <property type="entry name" value="Deoxyhypusine hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03101">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027517">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697:SF5">
        <property type="entry name" value="DEOXYHYPUSINE HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697">
        <property type="entry name" value="PBS LYASE HEAT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 10 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="11">
        <location>
            <begin position="250"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN99300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="330" mass="36264" checksum="6CA643610D3C933F" modified="2014-11-26" version="1">MPDSTSRSVEELRKDYAKLLDPQEPLDSRMRELYRLKENCLKTVAGVTVILEAIDTTDSVLLQHELAYNAGQSGLEEAVPELERILRTVSYDVVMRHEAAEALGAIGSSLALQVLEAHSDPTTEPEAPIRETCELALARIERKEAKGSAAVAPPSGCEFVSVDPSPAFSALDSSTDEPVPQTVEELEAVLLDTSGRTRLFRRYMAMFTLRNLATEAAVAALCRGLREDTVSPLFRHEVAFVLGQLEHPSSQPALIAALKDEEEAAMVRHEAAEALGAIADPATLPVLESYATHHEPIVRDSCVVALEMHKYWTNFNTLAHQQQQQQEQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUC0</accession>
    <name>A0A088RUC0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Obg-like ATPase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_272340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700320.1">
        <property type="nucleotide sequence ID" value="XM_010702018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUC0"/>
    <dbReference type="GeneID" id="22576412"/>
    <dbReference type="KEGG" id="lpan:LPMP_272340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270031700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_272340"/>
    <dbReference type="eggNOG" id="KOG1491">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="424823at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.300:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="entry name" value="TGS-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00944">
        <property type="entry name" value="YchF_OLA1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00092">
        <property type="entry name" value="redox-regulated ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF11">
        <property type="entry name" value="OBG-LIKE ATPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="23"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="5">
        <location>
            <begin position="301"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="32"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN99613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="392" mass="44036" checksum="217DA2C3E9F1F5E4" modified="2014-11-26" version="1">MAPKKQEKAESKTVLLGRPGSNLKVGIVGLPNVGKSTFFNVLSKKGVPAENRPFCTIDPNTADINIPDDRFDKLVRIHKPASIVPAQVHICDIAGLVRGASNGEGLGNNFLSHISSCDGIIHMVRVFEEMEITHVEGDLDPIRDLEIIFSELVMKDLQCVNALIDKLTPIVNRGLDKSKKSDLETLHRVKGVLEEGKQVRCCQWNGKEIDFLNTVQLLTAKPAMFLVNMSENDYVRQRNKWLKKLKDWIDEHTGEPMIPFSAELETTFIAMSPEEVDRYCAEKTTRSQVHKIVNTAYSIINLIHYFTAGADEVKCWTIQRGTKAPQAAGRIHTDMEKGFICAEVIEWADFDRLENEAACRDEGKQHQQGRNYEVQDGDIIFFKFNAAKGGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUF8</accession>
    <name>A0A088RUF8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BILBO1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_281340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700474.1">
        <property type="nucleotide sequence ID" value="XM_010702172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUF8"/>
    <dbReference type="GeneID" id="22576579"/>
    <dbReference type="KEGG" id="lpan:LPMP_281340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280019400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_281340"/>
    <dbReference type="eggNOG" id="ENOG502RYVN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271919at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.650">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="439" mass="49798" checksum="2A092A2D69531BD3" modified="2014-11-26" version="1">MSFTLMACTDIRGQKVNVELPFQQPPDSMEALRGALEHIFREEEEAIKYAKGYTDTRACEPFTIIRLQRYNDDSQSWEDLTSIDVLQTYDQLYVFRKNSTKADISPQRELPLPRISDFFYDLKASASHRTPRRSSRVKENGTAAALGPTSVGHGGSVSPNHVRRSAGGSPYRTSGASSSAPPPRRPEHYHVDDPYPASAVPPMNIAAVPVPQPPSSSFYYKERTTPERVEYLFSLGRQSNNGALLTEKAFVHIFRMASVAFPVEVLQDLFAYFATRGDGGAGTATMSTKDFQEFATYFPVLVNIAYQRITNQHREEAIRAAQLESSKQVKHARRQLEELAAQLAAARKEMQQTEQRQARLQEDLYELNMQRDPGHCQEEQALLEKEVSVFKYRERLSREERDYERLAIERRKRAVASSTRARSNSPQGGYDANRYGPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUI4</accession>
    <name>A0A088RUI4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_271860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700272.1">
        <property type="nucleotide sequence ID" value="XM_010701970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUI4"/>
    <dbReference type="GeneID" id="22576364"/>
    <dbReference type="KEGG" id="lpan:LPMP_271860"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270026800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_271860"/>
    <dbReference type="eggNOG" id="ENOG502QVRB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="244508at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="517" mass="56682" checksum="732C67F781EFE502" modified="2014-11-26" version="1">MTFNRPRGRDTFSVAFASRLRIVPLTQMSDLYGPIDVSLLTAVNADDPTSSEGNPLEKKKYMAGDARARKVVEDKQRVEATLREKRDWHVLVVDPIELHMVRTPVPFPSPHPAYYNDWTTTEVKGWSSSQVLERLPTAEFGIPTPASPSDTTEAGAEAAVAADAAGGTVAKVDAPETPAFFYTAGDRRHLQQNGDTTLLSSAQVRQTTLGIPSSTSTATQPLQCSPHTIRQHFHTAVCVDPDISHDRFHREEAQVEMISAYRNILYEAVELGHALSSSSAGSNLRGRAATQRAVPFVADVVRVPALCHYSCGRRFLHELGKLNQQAVIKGFHRLSNEAKEALIMNRSFTVEIYVPPMLLEQFERAFLEEPWEVPLSTLNPGRTALYPGLAPPRTLLQYDGWIGKRPELVQGIATQGKSLLRGAKVGLDGRLIEEHEVLASLRVFGAREEQQQMLEGERRTAAEQLGVPLQPTYAPLHAGLQAEVEPHERDEGPEKPSGSCADAGPAVVATSARESAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUT0</accession>
    <name>A0A088RUT0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_281350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700475.1">
        <property type="nucleotide sequence ID" value="XM_010702173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUT0"/>
    <dbReference type="GeneID" id="22576580"/>
    <dbReference type="KEGG" id="lpan:LPMP_281350"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280019500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_281350"/>
    <dbReference type="eggNOG" id="ENOG502SB9W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273598at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1074"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1074"/>
            <end position="1084"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1120" mass="123760" checksum="282BD18DE5433676" modified="2014-11-26" version="1">MHMLTHTAPQHEAAALLVRSRSAFHPLENAGDCGEACEESNRALPPLATSASSSKSRGLHVSNDALLPNPWRQRTTLDDLEDRQRRDPHGVAQFRPVLQASRDSFRSPSNGLKPLLEPYLCAQNLAQEVRVDTWHLRRARYLQWLRKGAATAPERQVVHGGPSCQAAYLGMKMSTVTRLGSGDNSASTTRRTFKASGKSHLESLRTGTSSTTHPSMPLLSPSLHTTLPEVKEYNVSPTHTSVSVRERISAASNTSLLLSRTNPNEVAVRCLFQAARMGAAAVVGNSAVETTSLSKPDEVASSLSVQCTSESLQRWPHASLVHETTGGLDNGGGATLPCEHRGAGAMAVDINTFAKAVGASGAASGPPRDLFGDLFTDDVTFGLFDLGNEARGKEECANTSNSTMALPPEYDLVDILRNRMHRVVATFTPSSKHTLDEPPVMAKTHTILGKARLATNTPTQALLVKLVESERASRTAVNDEAFPAQQLSAASESVARALQRLLYEEEYERDLLRQLALQSSPTRWYSTLLPSGKEGVRFRLAIPPTMTDDIVICERLRSAMLHAAQAIAQPRCDAVAAEKACRHATLPVFKNTCGGQSWCPEEHARLMVERAASAKALLFQQWTSLHAKLSAQLCLFTEEAEQRHRLLGEFLSCMHPAPCVCLTCDLEVLAMSAVQLEPTVKPVCWYVSVVLGRHKDVLQQELLVQYQAEFNRLYDFFRVEFSALYSYKKLVADEGRRFRQTIQYHEFCLRVAASHQNGQQQPRSEATSPEDALMLRPSSPSSIACTPERTALAEVVLNSAASTPMRASSLYHGDSRMWRLRQRRLRNCAALDSPFFSYLLYTEVLITAVTEDEVRTVIVVSETAARAELKTHMLAEESCLRLLEREWQNRARIVAEQDEAYNTMHAGPLVELHAAHVAEVQAVQTATYAKCCKEALQSFVEAAVAEKLAAGMAELNWYCPFVCKTRHLALTLLVVDSSATQSKASSRKWLDRQQHMSLFNSEQRLRDRTVLVEEADARECITAAAEVSLRHARQLEAHRLSEEMAAVRKAALLAAEAIQRARDKEEATIRAQLQREERAVDPSKRPSTNMRPDTVNSFLVMTTALEEDFEVFLPSLSSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUU6</accession>
    <name>A0A088RUU6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_281600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700500.1">
        <property type="nucleotide sequence ID" value="XM_010702198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUU6"/>
    <dbReference type="GeneID" id="22576605"/>
    <dbReference type="KEGG" id="lpan:LPMP_281600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280022200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_281600"/>
    <dbReference type="eggNOG" id="ENOG502S9PX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269173at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006696">
        <property type="entry name" value="DUF423"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04241">
        <property type="entry name" value="DUF423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN99793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="132" mass="14389" checksum="25A863820A7E97DD" modified="2014-11-26" version="1">MMFLKGAHVPIILVGCVGLSSFAMDALGAHLKTKMSMRQRRSWLTANQYHMVHTVALAVIAWMMVLAKESPEASSRLNKGFYLILTGALGFAGSIYSLCLRICPKFMGPLTPTSGLVLVLGWTNVALAGLYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RV39</accession>
    <name>A0A088RV39_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">U-box domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_290770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700685.1">
        <property type="nucleotide sequence ID" value="XM_010702383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RV39"/>
    <dbReference type="GeneID" id="22576841"/>
    <dbReference type="KEGG" id="lpan:LPMP_290770"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290011900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_290770"/>
    <dbReference type="eggNOG" id="ENOG502RX7R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="424220at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16664">
        <property type="entry name" value="RING-Ubox_PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045210">
        <property type="entry name" value="RING-Ubox_PUB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052085">
        <property type="entry name" value="WD-SAM-U-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46573">
        <property type="entry name" value="WD REPEAT, SAM AND U-BOX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46573:SF1">
        <property type="entry name" value="WD REPEAT, SAM AND U-BOX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U-box" evidence="1">
        <location>
            <begin position="515"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="601" mass="66527" checksum="B17D30A7DED62ED0" modified="2014-11-26" version="1">MASVGQLDAYIQSGAVIDDARLDQWIQMSDISNAQGYYSGDAAAVSEAVRRVSRTVVAQYLNNADVQAVPLRRKTKFCLLLNNFSLYKPVRSVVFDCLEGMTSIFEKSVKDEGTMPFDSELGRMSEHVLVLLMRVMDYKLKAEAVHEFAEHNTQFAIQLLLAILLKEPPYEFELRCNCISGLLGFTQPQAFFGVGEKIEEHSCAKFTEKVDFMLNLMLRLQAIQVVSDVLGEAIASSETVPPLVQSAVNNTMWTIMNIFKFSSKEATQWRQHILLSTTFLDGTVMMHVQALAAKLHEAMTAPAPCVSSPVLHSLNLSFLFGAFATYHMEEASQEVRIFCTFFHDLFQLSIRPIVTDARVSGQVMVMYINLLHFMCNVDAMGEAPSYPMDGLMPELSSAALRATVEAFLKKEVGGCGLPFTEAWYRQFRRITPDTLIAQDSTTYQCIDNCFLSMITQLTAQQAPVVAQAAPAGGARLLGEMPALRPEKKNKISIDKAAVPIRHKMSPSAKQDSVEGMDADLLCSLTGAVMKNPVSSPYGQTYEKEVIMSWLGQNGSVCPITGRPLTAAQLTPNTAVATKIMQQIVRQTMTSQPVAEDDMYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVJ8</accession>
    <name>A0A088RVJ8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_283190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99950.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700657.1">
        <property type="nucleotide sequence ID" value="XM_010702355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVJ8"/>
    <dbReference type="GeneID" id="22576764"/>
    <dbReference type="KEGG" id="lpan:LPMP_283190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280039000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_283190"/>
    <dbReference type="eggNOG" id="ENOG502S6J9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273920at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36494">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36494:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99950.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1274" mass="128158" checksum="11C092C64F13967C" modified="2026-01-28" version="2">MSQPAKLCTSHNLGNPAENHLPVNNLFQPHNDNIHTEISSVKSKNVAFPKKDTFYEQIDQINSAALSAALPKGEGGEATQRVCVGPEGVWRCCVCHKVKDLKGPHLNGKASVRSDCWPCAKKTTFVHESSGDGPLEDAGRRAGRVAAAADVERLSVCGEHRTTVFKAPVVPSEAEEPSCMLPVTKAGRGQGSAAEGAGLAPLSGNVLWRCAVCHKVKDLKGPHLSGKTSVRSDCWPCAKKTTFLRDTCAIAGSGAAAEPVSSAPKMPPTAEGATPATSDAKASVLADHNIPPFLQTTACPSGFIGNPACVTPFKSTFGGVPAPDAAKPAATPFKSAFGGVPAPDAAKPAATPFKSAFGGVPAPDAAKPAATPFKSAFGGVPAPDAAKPAATPFKSAFGGVPAPDAAKPAATPFKSAFGGVPAPDAAKPAATPFKSAFGGVPAPDAAKPAATPFKSAFGGVPAPDAAKPAATPFKSAFGGVPAPDAAKPAATPFKSAFGGVPAPDAAKPAATPFKSAFGGVPAPDAAKPAATPFKSAFGGVPAPDAAKPAATPFKSAFGGVPAPDAAKPAATPFKSAFSGVPAPDAAKPAATPFKSAFGGVPAPDVAKPAATPFKSAFGGVPAPDAAKPAATPFKSAFGGVPAPDAAKPAATPFKSAFGGVPAPDAAKPAATPFKSAFGGVPAPDAAKPAATPFKSAFGGVPAPDAAKPAATPFKSAFGGVPAPDAAKPAATPFKSAFGGVPAPDAAKPAATPFKSAFGGVPAPDAAKPAATPFKSAFGGVPAPDAAKPAATPYKSGFDGISDAFFANHPTSVSLEGGFGGVGDSASTATSLAPCTENGMPMVSQRSSNKVSLSAALPKGEGGEATQRVCVGPEGVWRCCVCHKVKDLKGPHLNGKASVRSDCWPCAKKTTFVHESSGDGPLEDAGRRAGRVAAAADVERLSVCGEHRTTVFKAPVVPSEAEEPSCMLPVTKAGRGQGSAAEGAGLAPLSGNVLWRCAVCHKVKDLKGPHLSGKTSVRSDCWPCAKKTTFLRDTCAIAGSGAAAEPVSSAPKMPPTAEGATPATSDAKASVLADHNIPPFLQTTACPSGFIGNPACVTPFKSTFGGVPAPDAARTSALQLKTVFSEADNVDDVGFLTESKNPLEPSGGSKGTQCSAFEKEASFSVPSFAGDCAGESANASCGTLGSNMLVPSRATDSFSSVAVHSLITDALKEHREVIKAELECFRKDLLLEVRQLISRRHVYTVAEDRADFEEPAAQITESLIHRHLSKAFRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVQ3</accession>
    <name>A0A088RVQ3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_291440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700751.1">
        <property type="nucleotide sequence ID" value="XM_010702449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVQ3"/>
    <dbReference type="GeneID" id="22576908"/>
    <dbReference type="KEGG" id="lpan:LPMP_291440"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290018500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_291440"/>
    <dbReference type="eggNOG" id="KOG0144">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6159137at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="99"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO00094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="784" mass="84271" checksum="230D96C55087DD74" modified="2014-11-26" version="1">MPQVTENISSVDGTGNAVPQVRSPCHSVSSAIPVTNGLLSAGLTNSPCSEYPLSESSGGVVVRPQISGNVDDFQNFLDEPSNWEWAVNALSVEPGHSDRNIFVSKLPPTFKDVDLQEMFQNFGRVVSAKVMLNVKTGTSKETGFVQFTSYKDALRARAFFRLRLASLPTTPGMPAVVTQWAQNKHDGGLYGERCQQVHKLFIRNVPSSITQADMKAFVSRFGTVSVVSVHNDTYDSLPAFPTEQEQCLKFSSPSEGTEGEEAVRSSPEPSKHETIICFVTFVEDGAAMRACCQIHNTTPFDSCNGVPLMAKLAEDNSARHARRYHSAAAAYAAPASRGTCTDGWHGCSAYSSAAPTPLACAGGYHCRDGHSQVSASQHPLQKCNAASNYARQPSSTPVLSAGCLGTDLSRLYGSQSATPPSSPQSAECTSFNILAPRRAFRQRSVAMSTTATVPPETVITPPSPSLLFSTMSPSTQQEAHATRPRRVLLPPALSVEATTSDAMRMTISTTTPLASNPPHYAAAGFTHTSICSVVDSPMQARHHRQSTASASSMGNYRSISYTPVHTPHVEEQPQELYEQQQCQQQALLMGYDAGNDTYHPGDDFYQEYYYSGEIGPMESNLHPLSPSASSELLYQYGNAAGSVECNAYRTGNGHCSVAPLWQRRMERQRATAAYADPMATSAGLPHLLPCVAYGDQQPYAGADGSPSVGACMQAESWETNPSPRAKSAVAFPHALYPQAMVLNSGSQATTPSNGGSGSVRYRNNPYSMRVVQTIAQYSSPCVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVY3</accession>
    <name>A0A088RVY3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_291250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700733.1">
        <property type="nucleotide sequence ID" value="XM_010702431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVY3"/>
    <dbReference type="GeneID" id="22576889"/>
    <dbReference type="KEGG" id="lpan:LPMP_291250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290016700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_291250"/>
    <dbReference type="eggNOG" id="ENOG502SAA9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="263352at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="374" mass="40557" checksum="A1D34FA7105EDFE8" modified="2014-11-26" version="1">MAVPAGCHPERFERVTVYTDMVYAANTQLEGRGDDEEAAVLLALIRTSAAALARQLVVVDSKSLLPSAEQARPSLPPKRDTGTASVAASASTSTTVQLLRYWQAEEADVYTRDVNNIVSFMRDWECLITCKDIRDGAVTYALHRRQMPVLSLALTQTSTSTRTPKSAVEELLYTCVPSGATLKDKEDAITRFFTFPSELGAYVVAPSVTAAGEAKPQHSSEAASASATAAAAAVVLVNKNGYPVRLPWAASLLPPPPARFAGVLQKLCSANSAQMEVLRRRNPLLPGVLAAFHRYENRGLLRSALQRGCHVEVVETTEGDKAVVSAEDWVRRFVDLLTTGSDEADSQRRQTTAAATLKNFELKWLDLPLPQSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RW45</accession>
    <name>A0A088RW45_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Right handed beta helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_292720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700876.1">
        <property type="nucleotide sequence ID" value="XM_010702574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RW45"/>
    <dbReference type="GeneID" id="22577035"/>
    <dbReference type="KEGG" id="lpan:LPMP_292720"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_030015100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_292720"/>
    <dbReference type="eggNOG" id="KOG1777">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="427974at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051550">
        <property type="entry name" value="SCF-Subunits/Alg-Epimerases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22990">
        <property type="entry name" value="F-BOX ONLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22990:SF15">
        <property type="entry name" value="F-BOX ONLY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Right handed beta helix" evidence="2">
        <location>
            <begin position="111"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="278" mass="29211" checksum="C8913A4A69CCEB39" modified="2014-11-26" version="1">MPSQTIVVGPQADAHATTLAAALEQTTPGDTIVVSAGVFEETVHLLFNVTLAAAPVPENSEDTRSVRATIIGTVVVCANVTLDGLEVRGMVDVRKGHAVLERCDVHHGSDGVRVHPGATVTVHSSRVHHCIAGGDGVYFMAGSFGEVSQTDIFECRVNAIHVQGSEAVLRENRIHDCAFGVYYEKKAAGLCEQNTIEHVRKFGLYVTDGSNPVIRGNTVGWCGILCFFASKGGHSSCTGNTFEGSLHVLAECPVQLTGNQVSGTVDIDSGMSPVTVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWI0</accession>
    <name>A0A088RWI0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_300410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701076.1">
        <property type="nucleotide sequence ID" value="XM_010702774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWI0"/>
    <dbReference type="GeneID" id="22577095"/>
    <dbReference type="KEGG" id="lpan:LPMP_300410"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300009400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_300410"/>
    <dbReference type="eggNOG" id="KOG1552">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052920">
        <property type="entry name" value="DNA-binding_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43358">
        <property type="entry name" value="ALPHA/BETA-HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43358:SF4">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="2">
        <location>
            <begin position="93"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="383" mass="42417" checksum="286C4BAF52D7BBE0" modified="2014-11-26" version="1">MISARDALLQLTSGPGLMDNMCNFIIRPPRSTYEMEDLGPDVFRIDGDSKQRFMRHDFELENMRGLRFQCSWFKPYPGRRMPCVVYCHANCGGRYDGLEALFVLRQGFSLFCFDFCGSGMSEGEYISLGFYERQDLVAVMEFLTLKSDEVDGVALWGRSMGAVAAIMYASKDRWVRCIVCDSPFASLRLLIDDLVERHGGRTARVVPNMLVRGIVERIRKRIMKRAAFDIDDLDAVKYAKSCNVPALLFHGADDDFVSPTHSEMIRDAFPIPCLQQFTPGGHNCERCSDIQELISAFLQLYLIEKPQGARRTPVQRGLELANVATDATTKAATSGPSVPTGPTSNQPVSVTSYGTKDADPAPMSSPPASMAAYSPTTSTSTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWJ9</accession>
    <name>A0A088RWJ9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Splicing factor 3A, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_301790</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701204.1">
        <property type="nucleotide sequence ID" value="XM_010702902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWJ9"/>
    <dbReference type="GeneID" id="22577232"/>
    <dbReference type="KEGG" id="lpan:LPMP_301790"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300022100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_301790"/>
    <dbReference type="eggNOG" id="KOG2636">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2160351at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024598">
        <property type="entry name" value="SF3a60/Prp9_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF2">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11931">
        <property type="entry name" value="SF3a60_Prp9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="8">
        <location>
            <begin position="521"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="276"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="409"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIO00404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="619" mass="68948" checksum="E6A71368E8D5E4F2" modified="2014-11-26" version="1">MQTNALERIRALEADIERCIDSIVQQDLFADSIKNERHRILLDHFTLQQAGIVRYTAEKLLDVYLDEDDIVQAQNAPADSPDSIAAAVKEFEAKIADIREYHHTYRDLPPVRDELAVPNPRLLDDVFTVQERYGACFDVDAHYNRYSAFMVYTKSLAEGCASASAATKKGLAPLVPSSLLKWSSMWPGRLDFFSFTKALPQVLLHEVEAHRKVVGFALYKTFAAELLTYLEDFYHRIHPLKPVALERLMTEVESDAEKYWASLLESKAEVTSIAAAVSSEDDQTDVQDADGERANDREAGGTAGSSSKGRAVAPARIAVENKVACGLTIPPSLRHQVKKFSLWPLPLIEKVVQGVEQASDTSHSAAASASMYPASLADVKMVCIMEAKAAALLQSLLYTTLETTNKTLLRDYSRTIEELENDREVAEQEFLNSLGEVRQNSADTMEGTVAHAAEYNLKLALADSKGSGRGQLGKTSALAPGVPAPTAPELVLEEEEEQLIGENGEPIPRWLAQLHQLDKMFRCDVCGGAIYKGPKVFREHFGAERHAEGLRRLGVTHHLKSYEGITSIRQVVEMRERLTDGEGSFRKRLRDNTDNEEIQDARGHVVTAKEYLRLQQRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RX12</accession>
    <name>A0A088RX12_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_303320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701354.1">
        <property type="nucleotide sequence ID" value="XM_010703052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RX12"/>
    <dbReference type="GeneID" id="22577385"/>
    <dbReference type="KEGG" id="lpan:LPMP_303320"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300038100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_303320"/>
    <dbReference type="eggNOG" id="ENOG502R4AH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268667at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO00554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="321" mass="37995" checksum="FB9940CB9F2D2F6C" modified="2014-11-26" version="1">MWCSPVRCMSMWDSPVFEHNPLTRYWKKMMDRTGTTLSSQSIPRHIHGYLEGSNARTESHIRWFPYKQEMTVEGRYVPTFKDIIYTHYFPKEFNDDERVKYISIKTSRSELEVADEIFLMRKMKLFTAQLLRNKLRNRPLRMPQGVDYSGIERRYTLGISKVAQAMGMSMYSTNSYDPVLMYSPYLDMGDCVDLILTKQLRTSLQYLFCEIAVHRGIHRARLPHVKGEPKEPLHQIEPCLYQFIKLRLAVLSLIAKQEQYVVDHCFDGNHRYGGCLIHLFPSPLEPDIIDHHVEHIELDLELAQTWMKHYYDHYIAPRRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RX14</accession>
    <name>A0A088RX14_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_310740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701463.1">
        <property type="nucleotide sequence ID" value="XM_010703161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RX14"/>
    <dbReference type="GeneID" id="22577500"/>
    <dbReference type="KEGG" id="lpan:LPMP_310740"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310012700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_310740"/>
    <dbReference type="eggNOG" id="ENOG502RYR5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="245436at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030254">
        <property type="term" value="P:protein secretion by the type III secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16364">
        <property type="entry name" value="T3SC_I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010261">
        <property type="entry name" value="Tir_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05932">
        <property type="entry name" value="CesT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69635">
        <property type="entry name" value="Type III secretory system chaperone-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="29"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="310" mass="34789" checksum="4EEDD414536542E0" modified="2014-11-26" version="1">MEERQAFFVESTDGRKFKMVIRGDLGKLSVAKIRRYLRSYGVPENQQLLSGDRVLEDDMLGEDFGLEDEGVLHLWEPSVSRRPETAAIQSAPPPQQQQQRPYAPQETWRDEPAARSTQEMEREIERLQRQVDAAVARNADLENQLAQPAKSSADYAAHRGASGARGMSRSIDVDGLQVAKESLNMLSQKLQVSLYFDKNLTCVVGTDEDFSILLTYDPATERLYIYSSLLTELPENLPLRMKLYELLLEGSLLGREVCGGGIGLSTQNSVVVLTTSLPMRHCSAAALCETLPLFVETLLRWRSLVDELLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXE0</accession>
    <name>A0A088RXE0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_312360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701623.1">
        <property type="nucleotide sequence ID" value="XM_010703321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXE0"/>
    <dbReference type="GeneID" id="22577662"/>
    <dbReference type="KEGG" id="lpan:LPMP_312360"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310030900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_312360"/>
    <dbReference type="eggNOG" id="ENOG502RJQM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18487at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839108" description="EGF-like domain-containing protein" evidence="2">
        <location>
            <begin position="28"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="712"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="4">
        <location>
            <begin position="550"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="550"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO00823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="804" mass="85159" checksum="B0A4F2FCDE90176C" modified="2014-11-26" version="1">MLSAPRREAFWALLLTIALLSSTNGWASRASIVAYTATSVTRSQLADASLEHWAQYQTLCGAPGAARKIPLVDSLNRVFENVATANARFPFYAWGNSSWYVSSMGFLSPTPYGMCNGYCAARFFADLGGTYAFSSDTSVLYGGGGDWPMIGLYAMPFETTAASASESFILTLDSSADGAAYTAVEYCSVPALNQAATAEARLTAQVVVYANGTIIMRYASLPDTRALPAYMPSTGLIYSKTLRTVVPTPTAANGIAAYRFDPVLDACAGHGDAPACTADTGRGCVWCFSTSACCASTLVSEVCPRGQWTAPASSTAAFTPQQFYDVTVDFDTPFVAMADRSHTFALASGYFPLALANPQQNIPLFRTPSLERVYCIPGASCPMQTNTHPCGLLGNTCVNGNYTFSILALESEFIFAKAGRWDARALPQRSRGEELCEEAAGCAEGVVGRLTGAAFSNHYSSMPLFSVQLYADISGVVDVTIQCASCAPGDPMLAHPPMRVGLVRHGVDDASSVMIPQGLLRSGLHVRFVPKSSCVDCGVNGWCDESSGTCHCQPGYYGKSCAACPACWAGSECDDGSTGSGTCLCKGEACEAACAGTSGGSMASRSCAGCDAVGGRCNCGVCECQGGWGGADCNVAPADACRAYSFDGCEVCGQHEGCVFCHDSTCFNPALSGTPGGYTCSYSTPAADTQACATYRSRGWLPPISASALSAAGTWVTAGAVMAGFITIYVVCWCFSHQKRRDLTVQLAVGTTPTFLKPYREREVVQFDFTRERSLERELMGIPLRQVSLQRLFKRRKVNLMSEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXR5</accession>
    <name>A0A088RXR5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_311950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701584.1">
        <property type="nucleotide sequence ID" value="XM_010703282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXR5"/>
    <dbReference type="GeneID" id="22577621"/>
    <dbReference type="KEGG" id="lpan:LPMP_311950"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310026400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_311950"/>
    <dbReference type="eggNOG" id="ENOG502SHUT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267618at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="389" mass="40841" checksum="C266577EA89CC66E" modified="2014-11-26" version="1">MFHPAEDEMARREGYHMQRGAVHGMGMMLRMEEQQMLAMQMREMEMMQMQAMGCAPSYPDNQWASPQPQQQQGNTESIAKPSEAESVPATTPSLAAQSPAAPAGHVSISSRSATKPAHSGDANRTPPPTTTTSGGAGLPDTPSQVGAYCAYTPNSLYNTMPSTNNTKDLAAAQESTYNGSSMYGDSHSAYAPAFTGGGLSENGASGVGYSMYNATNSSSMYEQPAPSSGATDSSTVKNATAADIPASGNSSKAATPALQHRSLGTSVSPAPQHKLSVNTLDKKGSLAGMNGTDKSSTSTTHRSREIRQKNSELKRENSSGFIGGRSRGSFSRPPPQEKGASPSVDKDKRSPSSSAPKNNQPLSPSVDKDKSMHRSSSSSSDKGKGGRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RY30</accession>
    <name>A0A088RY30_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_292280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700832.1">
        <property type="nucleotide sequence ID" value="XM_010702530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RY30"/>
    <dbReference type="GeneID" id="22576991"/>
    <dbReference type="KEGG" id="lpan:LPMP_292280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290025000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_292280"/>
    <dbReference type="eggNOG" id="ENOG502RXK4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="250182at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF80">
        <property type="entry name" value="GRIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="28"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="708" mass="77257" checksum="D83292765C906DCE" modified="2014-11-26" version="1">MSSKEEVAALMASDGDFEKKISLLKKAVVTVTKQKQEVEARQKQLQEELSTTTQQLAEAQRANATLQRKVKSLEAQLEQERSSGSAFGQNMLKGLSSIMGNSDTTSRGGGRSGRGAANGQLALSQEDVERLIRENEELHRQTYTFKTKLEDAQRSGTKDTEKLRNEVARLQREAQELRHTLETATATRDTLRADYLTERALGDFCRHFFVASLRRRPQEPVSALAGTTVEVWWPANGPPLNPMAASLSDSMPAVVRERAVFTLQSAAGTVKTLLRGVSVLAMVLQEQLPSRERATVGDLECLCDRLSVFLAAHTAKKERLMHLLEQLDGQLSALQHPGEEDCPAPLSAGAFVEAQDEIVRLVSEWVGLLRAQLPLLVESCVSFLPHDHSYITHTADASAGSGGGAAAPPKVTTERGEFVEEVTRSGYATLASIEGSLMAMRMLVQRSPAAYHHCHNSGDQECAKLAPSTSREMLNFTSPLEATQPPIDLSSLLALQEFWWEGCASVRFLYTSIRVLNSGLVDIAEACNKSEVRDALHFIHKCLQTMAVASEEMNASSEAASADADEAIDMLSPAVTAPRMSAQAPSSNATSWASRPRAAIAMPSLLPEADGPRDTACADNYEELLVALSAADRAAASYYTQMNFLYEEMAEKEDAVQTALEAVEHLQRLITTERVEAKHTRQALQSQISLLSTQLIEKAETSVAHTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RY47</accession>
    <name>A0A088RY47_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_321990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701883.1">
        <property type="nucleotide sequence ID" value="XM_010703581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RY47"/>
    <dbReference type="GeneID" id="22577940"/>
    <dbReference type="KEGG" id="lpan:LPMP_321990"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320025500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_321990"/>
    <dbReference type="eggNOG" id="ENOG502S64C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="243665at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="601"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="601"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1232" mass="133925" checksum="43F23DD1EAC0831C" modified="2014-11-26" version="1">MTTLASALLTLTPSRFTDLVHSLVRVHFSIQPPSTGIQVKTPSSYEAAEVLTSLLTVSRLEHYMRDPSIAPLQLSEETLAASADDVVSLHSLSILASALEASVVAFSSTNVALVQEASTALPGQAGRNVHEPKEDGQHMSQAGVEASAWRGEKVVAYSSLLIHLVHAFTECLAVLTESSFSGSRASFVRMDLLLLAVFSLMKVADVCAYKAGRSSPGDGATAACVERFSAENVAEQLQCLCLQLSVVCHRLSSSMVMTWTTSERKLDHFRGIPFLWFVVRQATQLRMQMQVLNTAPPFAGCVAALQNLIFIYYVSILRCVIAADSASMNAHCSDVTPRVDERGTARAVETSAQPDRRAAASACLTGAEKVQLAKHVELLWADMKPKPVISPAELSDLQHRTVHTALNVSLATWWKSAAATAASAFPSTSYWSQRPQHMATLLGSYNSLLAECRAALPVLSAYSAAQTAALPSETATASSVSSSLSWFVPFHSRLIRVGLDLQVEATVLAALHLGIEPRAPPTPATPIAKWIASRHRQRLRRRGASGGAESKVMPNDAAGAGGSWGRVYRLCGGVRVAATELLYSAIEEVCCRVEERPLSKATSSSLSPPLHPSASRRPSLSSTTCANSGGVGSTSALAVALVNSVSRTFFAVPRMQYLFGYYTDATYTDRAAEEECRRVYAACLGVLVWLRELAPPFGVRAGEPPVARLVPPSSDVVRAAAGCHEPRAEDWLVCGTTSAIAMDGAFFVTYYLYHWPGQTGHPAGVSSAHGPQAERTAHDVALSFDGVFNGVPGPSISPLLTGATAVEYTKEMLFRLQHDTARQLRHLRATGRLHYFTGELQDKTKLLKDSTLRQRHVTSTLSVVQAHRKQPTLLWMPLGQAQEMVFLFDQYPRLFRCIDPAPSHGIRGVANEESDGGVMPPDGLREYPKVHVGDITCTFARVHGYLVKRLHVLSGILREYRSILLESSLHGAIDSHTISHGPSASVVAPMTSSFRGRLLDNATHSPQLEMHRRNNYEWAHVWAMQLHEEFPRLPARMEGAPRWSSGVMQMLERMERTMNDTHKQGLFINVVKSQQQYRELQRARSASPLPLPAEEAVLVDRTKGTSIEGPQVRDVVVQRDSERVPLGVVLDGDAKILRVQTMVTRPSGVADNSDEAEGDLLVSPFACALAQQQQEGQRLPGVSYRVGSFADVVGWRVLRVDGTAVYTGRDVAAQVRGKTEFTVTLQSFLGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYE7</accession>
    <name>A0A088RYE7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LicD/FKTN/FKRP nucleotidyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_321430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701829.1">
        <property type="nucleotide sequence ID" value="XM_010703527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYE7"/>
    <dbReference type="GeneID" id="22577884"/>
    <dbReference type="KEGG" id="lpan:LPMP_321430"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320019900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_321430"/>
    <dbReference type="eggNOG" id="ENOG502S00C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="444255at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009100">
        <property type="term" value="P:glycoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007074">
        <property type="entry name" value="LicD/FKTN/FKRP_NTP_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052942">
        <property type="entry name" value="LPS_cholinephosphotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43404">
        <property type="entry name" value="LIPOPOLYSACCHARIDE CHOLINEPHOSPHOTRANSFERASE LICD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43404:SF1">
        <property type="entry name" value="MNN4P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04991">
        <property type="entry name" value="LicD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="1">
        <location>
            <begin position="265"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="488" mass="53966" checksum="A421008252BCFD10" modified="2014-11-26" version="1">MQRYSRVWKSAAEAAFRPHLHREDCRICAAATSAQKDTKHVDSVTLSCAIDLGDGAASATSGSCTSSHQDASSFLSNMTSSVFELRRAALLEWQKRFFEPERKEGVSGVESLFRGERPDVLNNSADFDAVYEAYLRCEDVTVQEALFSRLVDWVDAQCSQPVEQSSVTPTPTPAAVTTSTAAVEEQQWGGVRIPQCLVAPRVDATLAPMTPKVTAPLIGVETGNVHAANDFETYVRRRFSEHLPCITKQLNFQEALLAVQTVLNSQNIRFFLACGTALGARRDGCFIPYDEDIDLGILYTDIVAPLANGDALPMPDFSSHSAAQPGLSCAQLRVYRLLHALSLTRAFVVFDICGAVEKGLELRILHMATSTRIDINLYYPPLCTTTCSGTDDASDDSLVRKLGAFVWASSFYEAADARKHHMYRYRHKPFATELEELSFCAKTTSLGSGFLVPPERYLVENYGEDWRTPKQYSYTEGLAGEFKNILKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYI2</accession>
    <name>A0A088RYI2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pyridoxal kinase</fullName>
            <ecNumber evidence="2">2.7.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_301300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyridoxine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.35" evidence="2"/>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701160.1">
        <property type="nucleotide sequence ID" value="XM_010702858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYI2"/>
    <dbReference type="GeneID" id="22577184"/>
    <dbReference type="KEGG" id="lpan:LPMP_301300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300018000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_301300"/>
    <dbReference type="eggNOG" id="KOG2599">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3689at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008478">
        <property type="term" value="F:pyridoxal kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009443">
        <property type="term" value="P:pyridoxal 5'-phosphate salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01173">
        <property type="entry name" value="pyridoxal_pyridoxamine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004625">
        <property type="entry name" value="PyrdxlKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00687">
        <property type="entry name" value="pyridox_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534:SF2">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="7">
        <location>
            <begin position="81"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO00360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="302" mass="33132" checksum="67B1531114FFD789" modified="2014-11-26" version="1">MSSDKSVLSIQSHVTHGYVGNKAATFPLQLHGFDVDAINTVSLSNHSGYPVIKGHRMDLTEFTTLLDGLRANDFLSDYAYVLTGYINNADIIRHVAATVAEVREKRQQQGKKDIVFFCDPVMGDDGRLYCKEEVVAAYRELVAHANIATPNYFEASILSTVEVKDLMSAIEAANWFHEQGTPTVVIKSFTMPDDPTHLRFLLSCHDKVTGSTKRYTGVVQYYEGRYTGTGDVFAASLVAFAHNHPIDLAVGKAMGVLQDLIKATVERGGSGKATLNSRELRVTSDPDRLLHPSTVISVTPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYV2</accession>
    <name>A0A088RYV2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_322320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701916.1">
        <property type="nucleotide sequence ID" value="XM_010703614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYV2"/>
    <dbReference type="GeneID" id="22577973"/>
    <dbReference type="KEGG" id="lpan:LPMP_322320"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320029100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_322320"/>
    <dbReference type="eggNOG" id="ENOG502SKXR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266643at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="610" mass="64997" checksum="0EE84CF9B0C43608" modified="2014-11-26" version="1">MGCVNCRVSKFLRCCRKNAEEASGEKEGEPRAVAEQTPVAPNAYTATSAANRFPSAERKDTAPPQTDVSADVAPEEAGRDRGWGSKEEGNSKGTAGTDSGSIKASLDGELGATESSKSNGETSEERKDKRQRRRNCGGNSSSGISLSLSINDAESAKDRSSSSQAHKSTKGRKEQTKKHGSSSSTITAEVCLQGTKDDVVVHSQHHSEPHSQVTGAGSSTNGVTVAGTISSINLHQAGGSTINHGSSNASLDVCSSAAPAVMDTKICQSDDAPDDDADRGGKTRRYVPAVVPALAPSIQNGRAATEVSYVSSRTSFEPYSDFGPRDGDDYLPPYEWAPRALPVSSPLRACGPVDMARWEYGENQLYGLAVAGETACFQDPMLSFADEDATVSDPATPEVNYGASYLSLHTFYPRLPPAQGPSSNAEGNDNMSREPAEAFNYPSVSVDGLIQKAYSHQQQPTYQAMYGGNMDAHYSPAEYTANETTPPALVDVNVSENGDYTPPLPVKTAHPFYPSILLPTQRSREVPHGVTGKPTTYPHALPTMAIAAPHVSENSDRSRSGNSNVASIQVGSYLYKPVTYLFDRSIDDWLTSRRVPSSKTESYAGVADMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZA2</accession>
    <name>A0A088RZA2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Small GTP-binding protein Rab18, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_331920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702283.1">
        <property type="nucleotide sequence ID" value="XM_010703981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZA2"/>
    <dbReference type="GeneID" id="22578345"/>
    <dbReference type="KEGG" id="lpan:LPMP_331920"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330026300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_331920"/>
    <dbReference type="eggNOG" id="KOG0078">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01863">
        <property type="entry name" value="Rab18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001918">
        <property type="entry name" value="Small GTP-binding protein Rab18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="218" mass="23696" checksum="3E7D72B773E7E966" modified="2014-11-26" version="1">MSSTTGADKTIKVLLIGDSGVGKSSLLLSFTTGAFDGNIPSTIGIDFKVKKVDVVDAHTGGKATVNLQLWDTAGQERFRTLTSSYYRGAQAVVLVYDVNEPKSFHGLKKWLDEANSYCRRDEAESNSMVFLLIGNKADLCPDENSMPLPLSTAQGFAQQNNMLFALTSAKTRIGVTQAFDEVARSVYDKLQDLEQYERRRMTNLNGGSNTGEGGQGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZC4</accession>
    <name>A0A088RZC4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="13">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LPMP_324050</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="13"/>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702086.1">
        <property type="nucleotide sequence ID" value="XM_010703784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZC4"/>
    <dbReference type="GeneID" id="22578146"/>
    <dbReference type="KEGG" id="lpan:LPMP_324050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320047800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_324050"/>
    <dbReference type="eggNOG" id="KOG1123">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262986at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18789">
        <property type="entry name" value="SF2_C_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002931">
        <property type="entry name" value="DNA repair helicase XPB-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050615">
        <property type="entry name" value="ATP-dep_DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001161">
        <property type="entry name" value="XPB/Ssl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00603">
        <property type="entry name" value="rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274">
        <property type="entry name" value="RAD25/XP-B DNA REPAIR HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="230"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="502"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AIO01286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="803" mass="89275" checksum="5C83381291665331" modified="2014-11-26" version="1">MAYSLNGDARIGEKCLFVESRAQSDGYIMILAESFRGSYETIRPLLTTLAEAVSRPSLIHEYRLTPFSLGAAVSNGIDATEATTFLETYAYGLAACSERRQRVRQFIESCMRRYNLVRVIIDSARTLVQCKNEETAQMLLCDTVITSVAATPPQIFYETSSWAENPAPYPSFLLQSRAMSKVVAARCMVLGFPIQQQYDFENDTSVRKAHISLRTQTKPRRYQIEAVDAAIHDGTLNSGCILLPCGAGKTLLGIMLMCKVKKPTLVVCAGSVSVEQWRSQILDYATLEAPSPTDNDDAADTQGGCSHQIKSGATRIACLTGKQKDPITEETDVVLTTYSMLVTAHKAKLRQHATTTAGEDDLFTGRGLRKRKENPKEKLFAPYGLLILDEVHVMPAESFRGSLGFIDAKGIVGLTATYVREDHKILDLFHLVGPKLYDISMEALASQGYLANVHCVEVRTPMTKEFGLEYMDHRRRAAGTSKTPVLVMLAAANPNKMMCVRELVWQHLDVGAKILVCCDHIMLLKEYGELLNAPVICGSTQHKERLMIFSDFQSTSKINVICVSRVGDVSVNLPNANVVIQVSSHGGSRRQEAQRLGRILRPKERAANGRAVDAWFYSIISMDTIEMNYAAHRTAFLVDQGYACRVMEYIPFESSANTSLGRMKQLAKKERVGDAVSIKQEFLYETVHQSSVLWSRAAERSGHSAGADDRRTESLSYQLGLLSKVVSSWEMEFQQECRKRRRTAAEDVAENATDDADGVTEARSMRTYAAIKNEWRISGDHETRATALHNLVGVEDGFVYHEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZK1</accession>
    <name>A0A088RZK1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Leucine-rich repeat protein (LRRP)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_311070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701495.1">
        <property type="nucleotide sequence ID" value="XM_010703193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZK1"/>
    <dbReference type="GeneID" id="22577533"/>
    <dbReference type="KEGG" id="lpan:LPMP_311070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310017500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_311070"/>
    <dbReference type="eggNOG" id="ENOG502SMGI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264571at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO00695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="638" mass="70052" checksum="AAED522AD5C81F98" modified="2014-11-26" version="1">MATTKQQQLYLNQNNQPQVMNGSADRNAATDSAVPLGSSKRSAEHLSRVAFNNILQYTPHIPSMCCAAAHPHLRYAREAVAGTRVAKGSAHRRSDLYVCWDWTTSCEYHSLSGSEDELVSDLRQLGWWLTRPFTKDGEPMVMEVNVKRQASSHPSLSSLSSATAASAETPPKGLESVLCILTQPPFQRTDAGISCLRSLILAPNCMEVSKTAVELIGQLTHLEKLESFTQFMPLPLPLVESLTVLRLRNVRTLTSLEPLLPLSGLKRLSLCRCASLRSVAALSQLPELTELRVADCHVLDLRGDYSVCRRLTSVSMRWCRDVLHVGDLATLPNLRELDCSYSGVRDVEGLTRCTQLRRLCLRGCQSVHELFRAMDVPAALIDSAARTAVTAVSTVFLDRMRAPAIMGEGVGFSTAKKPASTGDTAAPSARIVLYPILSTRLPSSAASLSLLEELDVGESNLVSLSGLSQYAPELRHLTVRECQQLHSLSPLGELLRLTSVDASFSGVDELEGLSESVSLQYVNLNNCVRLHTAAPLARVRSLREIHLSAWNQNCIICIHSLEVNMNSESAGGRHRQRSQSELIQQSSLRLSGPVEGVNDSRIDMAVNQESSHGRLQHHVLRQEAEELLRQPLEQLLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZW8</accession>
    <name>A0A088RZW8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Copper-transporting ATPase-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_332200</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702311.1">
        <property type="nucleotide sequence ID" value="XM_010704009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZW8"/>
    <dbReference type="GeneID" id="22578373"/>
    <dbReference type="KEGG" id="lpan:LPMP_332200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330029400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_332200"/>
    <dbReference type="eggNOG" id="KOG0207">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd02094">
        <property type="entry name" value="P-type_ATPase_Cu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000030">
        <property type="entry name" value="Copper-exporting P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000020">
        <property type="entry name" value="Copper-exporting P-type ATPase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF8">
        <property type="entry name" value="P-TYPE CU(+) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00942">
        <property type="entry name" value="CUATPASEI"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01229">
        <property type="entry name" value="COF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="487"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="671"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="713"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1069"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1104"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="12">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="12">
        <location>
            <begin position="216"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="12">
        <location>
            <begin position="323"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIO01511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1140" mass="122584" checksum="DC9702FDAA007A7D" modified="2014-11-26" version="1">MTCEECAQRMQESLRTLEGVHSVSVNLGAQLVEVDVDATDVTAAFRIEQRVTPMGYRVQSVVLPSLEAPGPEETQFSPLPPPLRPSVTSLSHVPAHASVSACCTSKLQRLSKTPESMARSSLGQHGASAPFSRRFRRVPCGCGGRGCMCAYGPEPEMMTEETHLLRKDDLEECLSEKASVPSSMDITVPVVQARASEWLRAPMAVRAMPKAAAVEATTNLLIEGMSCTSCAARIEAKLKQLDGILGASVNFSAMSGQVLHNPTLAPLEKVVGCVADMGYTVTAQDTTALLSTADGETPQQGECTCSTNLRAIPVHVGSVMSGYEHRLVVQGMSCASCATRIEHTLLQMPTVLSCTVSFAMGTAVITTRTPGDHTDAVKMVRSMGYVVMDTALLELDSSISRTREALERTREITEHERNLMGSALLSVPLAVVMVLMMFMDIMAWPLLARIISGMQFCTATLIVFHYGRGFFLSAWRSWQHDAYTMDTLVAIGTGCTYVYSLVVYLLTLFVYPQARMMTYFDTAGMLTTFMLLGRFLEARAKRSTSGALIELMGLMPTTAVCVQPDGSEVRVSLSKLQKGALVRVLAGDRVPVDGTVLEGSSELDEQMVTGESLWKTKRPGEEVIGGTLNLTASLLIRADKVGEETMIAQVLRIVQEAQHTKPSMQRAADRIARSFVPFVLVFSLVTLGVWLVLGATDAYPASWREAETSWQAFAFNFFISTVVAACPCALGLATPTAIMVGTGVGAKNGVLVKSGAMLEEVRRVNCVVLDKTGTITKGRLEVVRTHTTMSGLASPPMMAAQLHDSLDAALVRYLVGLVEAQSNHPVAKAVSAKLLAETEDSANAVPRRARYEVSSVVTHGGKGVEASVSVTPVSDNSHELSSVPPPPRVYCLLVGNVAFLRAHGVLLAPELAQLVEEENGRGLTTVVAAVNGAACVVVSLADEPKREAHGVIRYLQKTGIRVLMVTGDNAGVAGRIAAETGIHSKDVCAEALPITKANIVKELQERGYRVMFVGDGINDSSALVQANVGVALGAGTEVAIEAADAVLVRDSLVDLLNLRSLSCVTVRRIYGNFFWAFGYNLLMLPTASGLLYPFFRIQLPPVTAGAAMILSSLSVLMSSLSIRYFRAHRERDFYLEWANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZX6</accession>
    <name>A0A088RZX6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aminopeptidase, putative</fullName>
            <ecNumber evidence="6">3.4.11.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_332680</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M17 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="6"/>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702359.1">
        <property type="nucleotide sequence ID" value="XM_010704057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZX6"/>
    <dbReference type="MEROPS" id="M17.014"/>
    <dbReference type="GeneID" id="22578421"/>
    <dbReference type="KEGG" id="lpan:LPMP_332680"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330034700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_332680"/>
    <dbReference type="eggNOG" id="KOG2597">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="412814at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10590:FF:000002">
        <property type="entry name" value="Aminopeptidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000035">
        <property type="entry name" value="Probable aminopeptidase NPEPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10590">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041417">
        <property type="entry name" value="NPEPL1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963:SF48">
        <property type="entry name" value="DIPEPTIDASE B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="LEUCINE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18295">
        <property type="entry name" value="Pdase_M17_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytosol aminopeptidase" evidence="5">
        <location>
            <begin position="374"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO01559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="527" mass="56175" checksum="7CB62B8D4A29D13B" modified="2014-11-26" version="1">MSTYKRVRSESAREEANVSAFVDSCVNFESNVTFYTVEKGHELTAKAGRVQTMLVLGTDAQLKETSATAVCPYYDAAACAAAATAPESRAHVVKVTTTVRLLIGKVPSVASRHNCPSRPDQVSEIVKHAMAECPAADVEAGLDIYYLGRGQEVSVATAIARSCNQSFTAKRGRAEKSYLNAGRPVRVVMLSGKTASLAVIAQCVQLCQRLVNAPTNLLDTVTFTEIAMRWIDKLKAAGSDVVTDVMAGEELRERGYGGLYGTGKAAEYPPHLVTLSYKPRACISPKDRVAFVGKGIVYDTGGLAIKSRDGMCTMKHDMGGAAAVFCGLLCLAMLHAPIEATSILCLADNAVGPCSQRNDDILRMKSGVTVEINNTDAEGRLVLADGVYHASKELSYTPSIIVDMATLTGAQGIATGQHHAAIYANTDASEKRFVASGKVCGDLCFPVVYCPEFHNPEFYSAVADYKNSVKSRSNAQVSCAGQFIGNNLAKDYNGEWVHVDLAAPATRDEATGFGVALIAHIFAAELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0C4</accession>
    <name>A0A088S0C4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_342270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702653.1">
        <property type="nucleotide sequence ID" value="XM_010704351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0C4"/>
    <dbReference type="GeneID" id="22578732"/>
    <dbReference type="KEGG" id="lpan:LPMP_342270"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340028700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_342270"/>
    <dbReference type="eggNOG" id="KOG1868">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265306at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000232">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF23">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE USP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="499"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="882"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="364"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="403"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="435"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="886"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="910"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="966" mass="103488" checksum="820340F8D064F8D8" modified="2014-11-26" version="1">MSYDPKQRFSHDSRGRPSSGFTAADRQLRSQSQKLSHSPQTSLISNTPSNPALHSPRQQSVVVTEQTTLLRSRTSIVSSSAQDASVRKHGSGATGGTAAEPSALVLRTQRVKGVSARKMDGSLTPSAKPQYSFGCDSPRDSPRDVDGPTILSSQRTPTASIKGHGLSSVVSTDSPSVARGGNQQADVIGRTDSGSTKGALLGASTTGSRDAPSVMANEWPSVLNTSVHRSLRRSMLGAEKGSTRFGSAAAVALSSSQAGSAGIENIATKRGSDGGGGSSLRTYPSNTATKNTAMPPSAAHLSNAPNGKYSSSTSAELPVSSPGLSQQPSATSRTTVVGSSTDSPNMIASPRPSPHSQTTRTGFAADAPPAVSAAQGAQGVSGRDTAKSLLVTPSSSLSNTLTQPHQLLPLSDPSPSPGSQTAMTTRANKNKAENAETSSDAASSSCASRPKPRPLSLQQLKPSVMTDASSSSALKSCDAPASTEEVLPLSVNQRHSAPIPLRNFGATCYLNSIVQCLLCTPGLLRALISDRERIVHEWEVERLSTTKRASSEAHRRSCAERNVPATSSLVDLYTAHPAPPIPVSQLLLNLKEACASSNDEFSSNGQKDAHEFLLTLLGVIHKEVCHSKPDVCEVFREVEDETKWEAYARLVRRLQQENNSTIYRFFGGITGCTIQCAKCHLVSYRFEAQLVISLPMTYRLPTLGSKIVMKCTSGKRDGKTQAEGSIAVDEMLREMFFSERGELLNGSMQVTCDRCKKLRDKTIWYSIEQWPPILVLHLKRFNNAGVKNESAVVFPYTFCSIENLEYQLYSVCCHRGSASFGHYTSYAYVQGEDEAAETDNNTATAATVVSDLFQSPLASMNSERLFSPRERQPTGCVGGFFTSDSISKENGSDSKGASETHNRNGNRKVNGKDEPLPEETESKTGKWYLCNDKHITEVTAPDVLSMTKEAYILFYRRVDGRHATVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S187</accession>
    <name>A0A088S187_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_330220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702115.1">
        <property type="nucleotide sequence ID" value="XM_010703813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S187"/>
    <dbReference type="GeneID" id="22578175"/>
    <dbReference type="KEGG" id="lpan:LPMP_330220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330007000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_330220"/>
    <dbReference type="eggNOG" id="ENOG502SFWU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272647at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="554" mass="60187" checksum="0E2F226F91A09B09" modified="2014-11-26" version="1">MAESTLDALQVGEQAPDDPGVDGHSLGTKATVAVGIACLSGYIGYSLVYSQQASVSQALWSREDENVASASSTVRPRVALVNMTDNLRLCAMAGLRAWLDVADEVEPEFPTVMFVDEEEAATVAGLAAEVRRAALFAWMEVKERNEMKAPSGLRPLCCVVFRTLTEVDGHALDDWDVQKVGLRQWHGKRFVTRHCVGVSVNGKHAMVLTHDVEGVIDVEPASALSGGRASDCGTLVRQYGAPSAASFHQWRLSTEMQSSFATDQPLAKSLLGQGVRLRDGPRCQLWQSPLHIFAALGAVLRYNRTDAPVYPDYVAIPVPVLQSTGAVDTSLWCRMMELAHRCPWPLVRRYAARQHDRMERKRQLSSTFVVVVSLAEENAAVTPDVLRIGEEHVAEWIRNMSSTLSTKKPSPTANRVCVRDAAAGANHLKVVPTIQVDLTDIICSVIAAEWLLIRVVSLFAAVGLTPALAQLVAVPRPQARASLLYPTPNSPHKHHLWLSRLTPASLWGSTERGTMPPCVAPTARTTQVGHYVGCAAALPLVGGFVVSEHDFSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1K7</accession>
    <name>A0A088S1K7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_345100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02129.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702929.1">
        <property type="nucleotide sequence ID" value="XM_010704627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1K7"/>
    <dbReference type="GeneID" id="22579015"/>
    <dbReference type="KEGG" id="lpan:LPMP_345100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340059200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_345100"/>
    <dbReference type="eggNOG" id="KOG0290">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="24670at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045159">
        <property type="entry name" value="DCAF7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19919">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO02129.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="483" mass="54025" checksum="28E8B3B2632467DB" modified="2026-01-28" version="2">MRPSLCVHTQCRPHIHTHTSNHLSLSLLPSVWSFLSSPFSFLVRECTCRCFGSLVVYVAPVLPPPPLSSIGVIFTTTHQFLHCSPLCRFFRLAARVVQLLGAWAGFCVYVCLPSLCGVRYSALFCTHTIMENPAAVEEREKKSSSISYVTPWVANGLSWANHPDKPFRLAISSYTKDYRNYVDIVEKNEDNEIVCRASWEHCYPPTKVVFPPRPLQCDAVITTADYLRLWEITEGAPKGEKTAPTHGDAQHEAKAKTINSKVTMKRVFDSAKPNDFCSPVTSCDWNSEDINTVACCSIDSTVTLWDVETGAQKTKLVAHDKDVYDIAFASAHTFASCGADGSVRFFDLRNMDHCTILYETQGLSPLLRLAWNQFDPYFIATFGIDSTDAVVIDMRYPTVPASQLSQLHQLPINNLTWSPQNAQNLCTVGEDGLVCVWEARAEKGRSILWCDCEVPINNVAWRRAQNEDWMAITTSKGAQLLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S226</accession>
    <name>A0A088S226_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_353160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703253.1">
        <property type="nucleotide sequence ID" value="XM_010704951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S226"/>
    <dbReference type="GeneID" id="22579345"/>
    <dbReference type="KEGG" id="lpan:LPMP_353160"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350039200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_353160"/>
    <dbReference type="eggNOG" id="ENOG502RFZ8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="243355at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="775"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="775"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="811" mass="88127" checksum="AC85493738662C91" modified="2014-11-26" version="1">MQTQVHKDVVKNITKASQLEDELQLSQAQHGVVVLDVYNAEWGHCKALSDTFRRLFTDAGDLVHLRFFAVECNAVLASLNDPDEVKVHRPRQKGMEVSKDTLVGFWKGILEQRQNHSKPFFAFYKEGKMRAQLEGIDTPKICRIVHNLCKQQNAASEYIMNADALHFWESHFSLSESEVTVSEFVRAVQALLGASAAELSETDLADITAKVQGASGPTVTAAHLQSFVGDSGSVKDAILTIITEKRAIATATPAAPLLPPEKEPQVNESGEKAADDEPRASLQSLSAVESNEAVKEAGADGKETEVVGTEVDADVVQGTFPTEDDATEVSYNEELPKPATDGSGEEPAVEPPTVDAAEADEAGRDTHELDEPVEAYPVEEQAAQQPEGNEPDNPYEELPEQQTATAVESPTSSLSLPAKEHHESDVEEALGTPADEPQREVDTQASSGATENDDNQQGEMLDDTRAPFPTPQPGMDTTELDDGNDEDPDEAPSSAPPADTVNTTGNQDESVINQIFTDRWITVTEEEMHVWNTVAALPLHYPESTTLMADLTNDTTPAHEALSTTADLPTLAEYLMAQGVPYPDINMMCIAADQKVGSESLSYGKLSLILMSCDPEEGKDLVPQCETFLKELSDGTLLRQQQSLAFTALALSASEAYPDECFCYCIPETAVAAFQGLAVDDVFILNALTPLKTAVPQGGQFILRIIGLPKVIELATTDENEDTMVLSQWYARLQVAEQGTDTLVAHFVENVCDDEFQDFLSSYIARLIEDENRLDKKHGDEEKATDGEFVDDEVVDGTSAEAATPIPEDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S281</accession>
    <name>A0A088S281_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_060200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703903.1">
        <property type="nucleotide sequence ID" value="XM_010705601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S281"/>
    <dbReference type="GeneID" id="22572226"/>
    <dbReference type="KEGG" id="lpan:LPMP_060200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060007500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_060200"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="444540at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051581">
        <property type="entry name" value="Ca-bind"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34524">
        <property type="entry name" value="CALCYPHOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34524:SF10">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="217"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN95581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="31660" checksum="803CBB10D38380F2" modified="2014-11-26" version="1">MKSSMVAVSSSLELTKKSFLADILRKAAERLGHKQLWRIANQLERLSSPVSADAVRDALRDISIFLSDEDYAHMCEAYTTGAAHGQQSARMIDTPALIHSLSTAPLLPRRKYAVDLVIRKLDPSGTGTVSYSSLSEHYDVLRHPEVRNGARSESDVVDAFFDNFAIDGSPMEQLTVAEMRMYCIGVSMLIKEDTDFELWCTRAFCLDRPKLEQGKGVSEVTGSHTYSRQSRLLGEERQHPLYTTTNGEYGKESTSADYSLPKYGLPQQFTRNLKGCAGGATSMNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2W4</accession>
    <name>A0A088S2W4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_354570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703389.1">
        <property type="nucleotide sequence ID" value="XM_010705087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2W4"/>
    <dbReference type="GeneID" id="22579485"/>
    <dbReference type="KEGG" id="lpan:LPMP_354570"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350054000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_354570"/>
    <dbReference type="eggNOG" id="ENOG502S2N1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277541at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO02589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="160" mass="17743" checksum="D49A43A4BF50CD10" modified="2014-11-26" version="1">MMRASFVCKAASAVACGATTATPSDLKMTSLHKLLTGEVQFRNNAPLKVCNIEHNFGPNWKSEIEDYAASLPTDQKNFLKRQVQRVWLTRYTSRELAEYCGEGPEHLDAVARDANIAQARAYAQKHGADQLEAYVNAEAKNAGWSDAETKRFLDIVKAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2Z9</accession>
    <name>A0A088S2Z9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cilia- and flagella-associated protein 206</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_356190</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CFAP206 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703548.1">
        <property type="nucleotide sequence ID" value="XM_010705246.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22579647"/>
    <dbReference type="KEGG" id="lpan:LPMP_356190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350070300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_356190"/>
    <dbReference type="eggNOG" id="KOG3079">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003356">
        <property type="term" value="P:regulation of cilium beat frequency"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021897">
        <property type="entry name" value="FAP206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21442">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21442:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="712"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="898"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1019"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1329"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1459"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1502"/>
            <end position="1553"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="572"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1329"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1345"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1462"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1523"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1543"/>
            <end position="1553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIO02748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2310" mass="258551" checksum="C4429D1DA3E34873" modified="2014-11-26" version="1">MKRTSPAVVAPEPVSPISVEDVWGRLWRALPSVQLQQAENAMNSQCTDRHEDTAALPLLSVVLPREEMAHLVSCVYLALHANAIDSDTEAAVEEVLRSPSLNKVSDKDLDGAAARTALRETYTNEDFIAFLESVPTRWMPDMIAAQKDTEEGRLWAEFNVELVDCVVNDEAPYNLLEPTDVLTIQRTAAAVHLEAPVTDYIEVVPPRLYPVVYDSLFERLQLNNDRCDTSLSLAQFRLFFEWFHGLHFSNTNAERANAAAEDVYNRYCDQRGQFTTTQFQLACEEMCAVYVQHCDAAAYLQQLVHRTEQVMCRATKDRSVNTAPQEERMNAEFFLHAEEVTLPSWRRDLTSPVTLYLPDELRAVQQEVDRYHRHRSPRILLVGPAGIGKSEVGRQLSEELHCVHLNVLELAVAALGEREQGTLAAELTVCLAQRAPVPMTLQVRLLQEAMTSARAEYRGYVFSDTLSCTADTTDACNEHFVRPLQLSEMARPDHVVEMCTSMPDVYQEYASARSGAAAAASQRAWDAFIKDEAKRAQDLEKAEIRADCEKILAHLVELEGVTGKTAPPVAELELARQKAMEAQDILHTLEEEEEAAEDAKKLLLPRSVTERLEEVRLRLSALIRDGRIEAGVEPLSSAANDAERAILLPSLEGQDWTSSWRKHVDYAKSRNCHVLVDPIASASTEQVTSFIAHVFHLHPCDEPALLGAAKMTEDQDSGEEGAYGQPTSVATDEERSRDVEAAAQEAGLSLSPVWKRYCPVTALEDQVLIEGAACYACTYRGHYYCFASASKRSAFMDFPVKYLRQRCSPDSKPVLVLADDTLVHSTSSVVEIMQQVVNETAARLNLTPYTVSEYVKLLEPRETLLQRRHTSFVNRQKAEEKARKARAERKELAIKAQAKKNKGKMEPSKPKLKRKVSRAGRVSFLQQALQQQQGSAATTGEARRGVPRAMDMEGPLSMADEKAMQIRATKKAAARTAPLLLSAVTSADLQAGFLRGLWEGSLLPETVLVLRPAGAPAAAIATERDEDDEETEKSDADTSDALVLSQVLKLLEKDPAFEQRSVTGGRGSASLQQPLTFNIFFVALPEAPGVPEVIAEVMQLLDPLAIQTSEAVVDEALGAEAEDAAEEEADEEAEDAAFLNPGEGEVSQVPRPPRHPLTQPVRRFLHQFGSRLNYCPVTLHERGILVQGRQEFCLAFVDGLYVFATQEARDAFARCPLRYVGELPPETFPPRVWLAGSTHSGKKTLAAELQEDYGVPFFVYDRQFFAECVEAVLTPGGRTVRGVYIPQDGQDRNPYVNRARMLLEEIRNRAKEEKTKLKAKAEAERLLQEREQRNEERAARSNVDSDVEDSEDEDNWDEAKEAALQESLEFEPEDPEDKEVRLRETYLRIASCVTRFSPFDTLGYVMICPPFSDSELEVLFDEGCIPEVVVRLNIAAETYAQRSALHAAQRHEAMQNAEVPHASAAEVEASKKATQLARDAARLQRRREKALRKWRRRHIGVNDIDSPSEAEDEAETQREQGHSGDASGGDNDSDSDAMVAASDNRDGQSATEKDYFTQEEELNEFMDGIEERLVEVVRIDGRAARRTVYRAVIEALGRHMRHRASLFYVPEVMRFEDAKARLTAGVCDLSSFGYEDPVHLYRYRHNGSQIECAWKPAGVRVGPEQQLEENERGYYVAGGAGDNESGNDHEPEEPEELSEVLSDEVQELRDVVNRCRRRRQRETALRVARVHRRLYFFENDDSLLCFVRDPWPFIRQPPPTPRLLQHPVVSVYEYDDRYTTENGGDKKRVLADSIAFNLRMKCMSVSSLLAWGAVHPHWHALRLDCMLAAQQGSVDPALVHKLLILYLSTAEVKRRGAVLHNLPSTASSAEALPQVACTAPIVKVMTTLFTSLKDGMAADLSAPNTDGEVGWWVAAVSALERHAAVRLPLPRPSVPLDASNLVAAVHGVEEYVQQTQEALLRKQRAFPVRLHNSYQVYSYVHRHLSQFGTFCPYEWLDHDDLVRSVRAPMVSPVATATWAPLSVSTSNEVDLRWGASYLNQYFFFSSADYLERFLNNPTTVTDPSKTKPMPKHFPVIASPPVNMAYLALEGCCPVLLYDTRDFRGMRGVIQPVAKKGSLDCVVEYDGNLYALLDREHMTRFLRRPWQYVDGAHLPQVLRRPLPTGTSPSDIVNHEEYIQRQLYDPVALALLAVAQERPIYPGLSVEESALKYIALYLKAHRDPASLSDFEEKTYRHYFEVYQQRATLYRSLPSSSSEARTKQKVAGGATGAVSLSSAALDREYCAIFEDSIADARDMSFFNRLPPPSEAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S332</accession>
    <name>A0A088S332_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_080730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="AIN95881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704203.1">
        <property type="nucleotide sequence ID" value="XM_010705901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S332"/>
    <dbReference type="GeneID" id="22572535"/>
    <dbReference type="KEGG" id="lpan:LPMP_080730"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000034100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_080730"/>
    <dbReference type="eggNOG" id="ENOG502SI9T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="259421at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38148">
        <property type="entry name" value="BAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38148:SF3">
        <property type="entry name" value="BAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="389" mass="43915" checksum="F0696B9B29F69153" modified="2014-11-26" version="1">MQKLRADLTKRLDTDNVTLTAYRDYEFERRVNDVRRLQSALNHFDNAVTQGMVAMKEIASAYEAVGQAFTELTLTNNNPVPDPNGGEELSPYPTEADVQYMSQPNTSIVAADYAASVASTRMPDEANSQVRRLAKIFADEARRINEGPPFQSYNAGIHRDVITRLLPVSEHLKSIGEYRHKRTEALERYNKYKAEVEKVEKQCTKKGKPFCDNKSHKKYAEKRDEAWREYIKRRDKFNSIFSMLMEVNDHAAAQIIHRYLTLNHEYLQQLVASMDRVLPAMAEVYPLNSEYNSVQNTLILEAVANARTPFADHSKGHSYRAVPCHGGDAEDDMGHEEGEEAVDLDGEAQESTLTSMSYDGTDHIVACARSKQPADCETDVKPSVVLESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S347</accession>
    <name>A0A088S347_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_355000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703431.1">
        <property type="nucleotide sequence ID" value="XM_010705129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S347"/>
    <dbReference type="GeneID" id="22579528"/>
    <dbReference type="KEGG" id="lpan:LPMP_355000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350058500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_355000"/>
    <dbReference type="eggNOG" id="ENOG502QQFE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1904536at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050576">
        <property type="entry name" value="Cilia_flagella_integrity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973:SF29">
        <property type="entry name" value="LEUCINE-RICH REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="260"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO02631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="33368" checksum="132084FC5A9B2825" modified="2014-11-26" version="1">METWNGVDGHAGATTMTESLILQQCRKHQGYSTPELNEKLYLHHLGFAQLNGLAAFTGCVVLYLDHNALSDLAALAALTRLDSLYLSCNALSHLDSLPHLPALRTLDVACNQIVTLNGLDEAAPQLETLLVGHNRLQCLHGVQGLSSLVSLDLSHNCIEDEKTTMACLFSHRTTLRTLLLHGNGLCRHTPHHRKCWIAALPALRFLDEYPVFDDERARAEAFTRGGAAAEADIRSAQHARAATEARERFAYYGGVREMQRDARRRNGAETPPAPCLPARTTGVGTGVVQDAGGGPVCLPSAREGRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3A6</accession>
    <name>A0A088S3A6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_344610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702880.1">
        <property type="nucleotide sequence ID" value="XM_010704578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3A6"/>
    <dbReference type="GeneID" id="22578966"/>
    <dbReference type="KEGG" id="lpan:LPMP_344610"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340054000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_344610"/>
    <dbReference type="eggNOG" id="ENOG502SB2B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271154at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="148" mass="16935" checksum="EB4385661564F2E3" modified="2014-11-26" version="1">MEVIMNYMYEIDPIHLVTSAVAQQMLAMVWFDCIVRQIDRYYVAADKGVRRVEHAITRYPGIMVSAATFACSCLRSLIVLTLVHMCDCSTLYQYQSAAMVAVVIGTMRVHRTFSCHRPIQIFVTETGYELVAAMTTAVVCYYMKKYNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3E0</accession>
    <name>A0A088S3E0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycosyl hydrolase, putative</fullName>
            <ecNumber evidence="7">3.2.1.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_355360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 65 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="7"/>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703466.1">
        <property type="nucleotide sequence ID" value="XM_010705164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3E0"/>
    <dbReference type="GeneID" id="22579564"/>
    <dbReference type="KEGG" id="lpan:LPMP_355360"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350062300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_355360"/>
    <dbReference type="eggNOG" id="KOG4125">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="200349at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000079">
        <property type="entry name" value="Putative glycosyl hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.40">
        <property type="entry name" value="Glycoside hydrolase, family 65, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037018">
        <property type="entry name" value="GH65_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005194">
        <property type="entry name" value="Glyco_hydro_65_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005195">
        <property type="entry name" value="Glyco_hydro_65_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005196">
        <property type="entry name" value="Glyco_hydro_65_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11051">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11051:SF8">
        <property type="entry name" value="PROTEIN-GLUCOSYLGALACTOSYLHYDROXYLYSINE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03633">
        <property type="entry name" value="Glyco_hydro_65C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03632">
        <property type="entry name" value="Glyco_hydro_65m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03636">
        <property type="entry name" value="Glyco_hydro_65N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 65 N-terminal" evidence="6">
        <location>
            <begin position="43"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 65 central catalytic" evidence="4">
        <location>
            <begin position="450"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 65 C-terminal" evidence="5">
        <location>
            <begin position="818"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="64"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="310"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="332"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO02666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1154" mass="128846" checksum="567CAB57B0EB19E1" modified="2014-11-26" version="1">MSSKATEDGTGSTSVERRIDAAIKVDRWELREDTLPVGSQVLVSETLFSLGNGLVGVRGHSEETQVGQNVHERHHAPTRSQRAYNNSRRGGDILPDKERKRSPASVGGKDWHHSHEHGDRNGGSSANSPCGLRGVYFSGFYEQRPLMHPHSFSVGISTKEGYRLRTPDAFCVDAFLSGEYISAAQGTTQCHTRRLDLRTGELHRRFVWFSNQQHREITIESRRFVSAARKNISAMHYKMSVRNAHNTDVRLISRTLLSAVEYDVEAMFTQSNIQDSMSVVLVRTRNSCRHLAIASVETCTSRSYSAGAQRFPSMDTSSTTQGAVSSDPAFMTSPSGAGPSSSVSPSSPAVVSPTTLTPSSRTTEWGTEASYTSCISDGVIIELVKIIGHFGDEDATTEELLDVATHQTREVAALGYEELLAEHCYAMSAFWDTADVRVEPKADVQGAFRFNILQTYMSTSGDPYYCFPTRGLTGDMLLGVQQWDVDALIVPFLSHACPKKARALLEFRIRTLNEAKDIAADMSLPRGALYPYRTVTGERNPTPYCGAFLFVNAVVVYALREYVTATSDTSILVQGGADLIFTTALVWLQWGTWEKGLFHLRSVSGPDTYNDVADNNFFTNLMAQMHLQWAVQLAVMLRQENPEMWCGIMQRAQMTENDIIAMDQAATKMVLPFDGTYRIHPMDQSFMRKKRWGLTSLKDGAGGPLMSLYHPTVVYRHQVCCIPDVLLAIMLAPDRFSLDEAKADFTFYEAVTASDAALRLAIFSVVAAQLRLPNKAMRYFHDALFVDIDNLIGNSGGGLHCTAAAGSWSSMAVGICGLRVAQGVLHFNPMLSEEMDEFEFHARHRGCLVRVLVTQRLVTYTLVSAPDSVTDLMLVHAGANRITLRLNHPETVRLFREVRVFDFDCVVFELDSVVKDIEDVHYQAWTQTLEEHFHQHGFSDFSMTKELYLAYLRHVKPFYGLNEIFKKYNHPPPLTGEVDDTAESNTLYGLCHRKLQLFRSYATTHGMPMREGVLQLISLLRQYGIAVGCVSGSKNARWVVNETTKGSSIFDSFLEGKEGESLGLRWRPEMDYFEACAHRMDAATNRAVVVMDGIDGFSKKALERFRMVIDVSPVPEETTLAIPRVLAKNLGDITMETLNEYTVRGRVVNHLREM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S5Y3</accession>
    <name>A0A088S5Y3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Membrane transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_160770</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in cellular auxin homeostasis by regulating auxin metabolism. Regulates intracellular auxin accumulation at the endoplasmic reticulum and thus auxin availability for nuclear auxin signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the auxin efflux carrier (TC 2.A.69.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN96951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697604.1">
        <property type="nucleotide sequence ID" value="XM_010699302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S5Y3"/>
    <dbReference type="GeneID" id="22573655"/>
    <dbReference type="KEGG" id="lpan:LPMP_160770"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160011900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_160770"/>
    <dbReference type="eggNOG" id="ENOG502QUIC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_transp_PIN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045033">
        <property type="entry name" value="PILS1/3/4/5/7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31651">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31651:SF33">
        <property type="entry name" value="PROTEIN PIN-LIKES 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="652"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="695"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="729"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN96951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="753" mass="82548" checksum="E55A1AFD65E86048" modified="2014-11-26" version="1">MNLLGVTFIAVSKVIVAVLVGVFTTSLIPHSAKTLRDFAYLISTILLTSLTVSNTAKSIDLDVLFRCSILILFSLFSIACGLLWGVLFGLVFFRPNPKYSGIPPDLRKDVRLDLLYDRVTAEGADHHGGPLSSSATTHPGSKKKKKRVPYVAVVLSEHFREAGVNESEIVNALEVTDERQEDYGGYNYASWVACSTQNGVTLPLSLMLNIASSVPYIDKEHTAAYIFVFSISYLLYLWSACPIFVEAGQKSVTKQRLIREILQKHKRMMSRCDATTQTLSLPVKYVPENDEDSAEDVRVDGRATGTRQTSSLEPQCTRFIQPLAASAAASGSIECSDNTSALEAGDEATRDARDTRVSVRADSATYTLDPITPLQNSFTQTDRKLTRAGGNRAGAEVISNTPGTPTPADLMAAECAYTMASAVQLPYDWAAAGFIRVKYESEIKALKKKSISEKVQHLGRGTWGLIKKAMTSPPFLATVLGIVIGIIPPVRRLFAGGPLEMVMDAIALIGEGSIPASLLLLGANLVGSSSTSESELSKLTQVRLRHAEQNTEYPLHPEVWRLLGEDATYARWYDEQHIDIEFDMHRSSLHMLMQGGPLPASTMASHANAASVAPMTEYGDEEGGGEGVGAKKKRTFMGGVRRTLSLRGIRPTFVWGIIIFRMLISPTLSFFLLVFLIKTMPFLFGGRGTLDKTLIMVLMVELAAPTAINSTLLFNAYQFMMYPWAKMLFLQYILCIMSMVMWTTIGLSYVSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S7J2</accession>
    <name>A0A088S7J2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_200640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698263.1">
        <property type="nucleotide sequence ID" value="XM_010699961.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22574271"/>
    <dbReference type="KEGG" id="lpan:LPMP_200640"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200010600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_200640"/>
    <dbReference type="eggNOG" id="ENOG502S1Q5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266612at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34491">
        <property type="entry name" value="A-TYPE INCLUSION PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34491:SF148">
        <property type="entry name" value="GLUCOAMYLASE S1_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="538"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="583"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="739"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1385"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1454"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1623"/>
            <end position="1653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1671"/>
            <end position="1788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1818"/>
            <end position="1949"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1982"/>
            <end position="2001"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2007"/>
            <end position="2103"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2146"/>
            <end position="2175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2216"/>
            <end position="2376"/>
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    </feature>
    <feature type="coiled-coil region" evidence="1">
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            <begin position="852"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="989"/>
            <end position="1023"/>
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    </feature>
    <feature type="coiled-coil region" evidence="1">
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            <begin position="1104"/>
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            <begin position="54"/>
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            <begin position="212"/>
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            <begin position="235"/>
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            <begin position="278"/>
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            <begin position="288"/>
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        </location>
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            <begin position="585"/>
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        </location>
    </feature>
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        <location>
            <begin position="648"/>
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        </location>
    </feature>
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            <begin position="1411"/>
            <end position="1421"/>
        </location>
    </feature>
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        <location>
            <begin position="1454"/>
            <end position="1468"/>
        </location>
    </feature>
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            <begin position="1491"/>
            <end position="1500"/>
        </location>
    </feature>
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        <location>
            <begin position="1623"/>
            <end position="1632"/>
        </location>
    </feature>
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        <location>
            <begin position="1637"/>
            <end position="1653"/>
        </location>
    </feature>
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        <location>
            <begin position="1709"/>
            <end position="1720"/>
        </location>
    </feature>
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        <location>
            <begin position="1721"/>
            <end position="1737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1829"/>
            <end position="1838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1907"/>
            <end position="1918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1937"/>
            <end position="1949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2013"/>
            <end position="2022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2029"/>
            <end position="2044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2152"/>
            <end position="2167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2216"/>
            <end position="2225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2288"/>
            <end position="2297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2304"/>
            <end position="2315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2349"/>
            <end position="2365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2376" mass="253500" checksum="22B9B0D77DB2F52F" modified="2014-11-26" version="1">MESPPAQAVSGEQRARLLELEERQRQLKRLCEEALREEEQHQHILQQLEEHNTGAVSSVESFAGGSAGSVSGAAALQGRPFSPSHGGEPLEDLLTGEVQSFRDPNSAVRESSTGSAAAPLWLRSESLSNPRNPSADRPRTVLSSSYRPPTYPLPMVFATQSPPPPREMLYSTSSRPREEGSSAAAAAMNRRIQPPTSAPVMSSSLPITSAWRHGERGTAERKSGSYSAAAALFPPAAPTPLSPPPPPPPPERSHSRGASHSIPSADRYWRSDARPYHGIPPPPPPPASDATQATASPSAVRYSWTPRAHTSLSPPRPPLSSRSSAFPLVSPDEVTDNPPAPPPRTHRRAAPSRDMPPSMPDTYRWPPSLLHTDSPPPPPPPPPPSPPAARTDSVGDSTLPTTPSERDIARWRRRLSGSGAVRPLSDNRPGSGYDRSGAATLANRRVPPAAVTPLLSVPYRETATKKGVRVAGRAPRSLPPPPPPPAPSVTLFSPARYGEGRNEDESLLDRWETASLTPSLRSAEERCLRNYFAKPVREVGSSSPTHRNYASYSRQRASPSCSGVKGVRTSLFEVAGTAEPRLQRRSTVIPTPDLFTSSAPTVMNTPPPAPAKPKPNKTALHPYELQHPQSPSLSPPPETSLNSTSARNCRDAPGHRGDTSAPLLSALYAKHQQSTSATLKSSNLDSARGNGDISLPANLDMTNKAATGEPHTAAAASVNDYFDMGPEKEALLSLLQESTRGAPGSNAGAALPATSCPSSIQQGMSPAMGANLAGGRRGEKALPYPLSANCLSERNQTQIFSTQPPMTTLPPHYKDPTAQHSYLNPTVDSSILRGGNVNAATRGVQHSNEVAAVQLQQKYDKAQAKAEALARHLVKAISDRKMLQGSVEQLEMLVEECNIEVGRLQQIVEQQHQDSATSLGVQAALRAKEREVAVYEDEIRRLHVVLNGHLTRTATAERVAQESVHQGLVVKEAEVEAAIAEVGMAHLAQREAEERASQLANELDTAVEQIQFLDERLAEMERAAAAALLPASRVHAAKEPGVDSDNGEAALAHSSAAAHLTIPPDEETRRWPLEARRTMAQLVAQAEGLLLKNAEGERHTSMRLQHMENTCSELQRHLRQRSEEVERAREAYEQLRQEKSTLQTVGEVWYQQLREVKEDAQLVSEMVRTSREDAEDVYLSSRVAEERAVVHRAAAAAASPLRPFPSSAPTDSTTLKKSAQFARQVMRDFHAVARFLSSLRTMNIGDRNGYQILQTIASGRNPAEGLYVTADDAATPKQVSELLAPNAASEAKRRVQEKKARVLRAVEQALIIGSDSAPEFASLDASEKRPPSRAPIMLGLPLRARERPSPAGAEVCEVPDAFEDELTNGDEAEVEVVFSSLHPTRMGSQSLRDGSSGMVHSDVRRRPASDSVASVSQNRMPPTSEIRRAAPAFAASPPAAPLAPDGKSFCSTLFTNSSEAPSTASTSQPTAVKAAPATPTPLPSVSRPLRLSNTPSQPQSEGKEENEEEALGPSEKHSSSIRASSHTVLRTDSMPICSTGAGIDSETHFITFVPLPSIPQQVPQLQTTTVQQAPLPPSTLAVTGGLPVDYIVDVSSSTAPFVSGIVMTDQEKDATVARRNAPTPLQMQQQHTPIPATLTNTSPSSSRLRSPTPDRLTAVWAGTHVDEVLIASPIEQRRSSQSFTDEPPPRVVCDENKQLGHLCSRPKNRSTTARPSSTPHPDSRSGTRRGFEARAEEETVAPPRHTDQHRRGASNRSNDDEATLFFREPPRGEVQEVASEATSTSLQEQQQICVEVDLLNEDFVMPSRRVSAAAVALASVSSVSPETTLIDEEEEADVEERVPSAGTAATRPSLHAESPLKRDHTAAPSVPDVSLVPLKDAKATKPSSSRNRRVVDEDDEPSLSFLAPPPPLPPPVRPSPSQVQTKRAQEKDALVLTSPTEASLSGTSYSQTMEDTSVAAVSTENVPHSPLSLCGSFAGAPLRLPHQPRRPSASDGHPSLTAVEGAVAPPRLQRSTGSSPLTAAQPLLGTFAPGPAAAGDATAGVSQRIRSGSRPPTARLSVDCPLLEATPALVEPRRHSPSARPVPAATHTNPVTPVDTVDFDSASTAGLSLLEQQTSPAPKKAQISRAHSEVDLHVDDLLRSDGKIGAKTTSSTPTSRLPSITSTAAPGSPQHVLEEPSVALGLPGEICNDTPGQLGSAVSLPAEALQAAPLHPREPPTRAEHSASPCCSPHEEAAPAPLPLVNADAPESSTLNLPYTSPKPAPPMEEAATFNGNRPATSPAVAQMPSSTISTPRSHGGGRQNSASVWSSTPAEQPMPDGITARRCEEVAKILMRLKAKKEQDPKQPSEMSTPTSPTGSEPSSAGLEDLDSPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S7N4</accession>
    <name>A0A088S7N4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal lipase-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_201090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698308.1">
        <property type="nucleotide sequence ID" value="XM_010700006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S7N4"/>
    <dbReference type="GeneID" id="22574316"/>
    <dbReference type="KEGG" id="lpan:LPMP_201090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200015900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201090"/>
    <dbReference type="eggNOG" id="ENOG502R5H7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="58570at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="621"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="3">
        <location>
            <begin position="916"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN97601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1028" mass="114344" checksum="774A9CDCD5B1E36E" modified="2014-11-26" version="1">MKGNQSRSGSCTASSSNVAKSSDGGTALAQALREVVQHGRTFFRAQYLYVRRRVTVIGKFIHITVRSLYFPDEFSFYLDTVVRFLFSVYYIPFLAMVFALTHAAIERIVWVLVIPVTQEMERRPFSTSCVPTLVYGLGSIASHMTPFATLAVTVATAGHKVMNCVAEAMVDAYTTQRDMDYPLLRARLRFTVKKKSRVVICGVVSASIAVAWVLLCHTNAFVEWSGREPWATAAAWTVFVIQICFVLTTMLREVPLENKALKGRRIFGLRDRRCHEEPTQLRNDMEMLPAADSQPLLQPVESTSLSQSSSMSVSSPLLVRRSAGSGSRWTASGGSGDSPPHHSPSDANSLATAQASTPAMAENVPNLLGPSASQVFVTYVEDDWWRHHIHTMRYIGFFMVVFFTIGFAVARGPVFGLTSGVMILTSLNAPHLFGHMALSTSAAVTRTLRSYTWLLRHPDALLPILMIATPYQLLLINAFRCFRQHPLLCLMLVWVNMLLAARAIDLAREFDVTVNGSVLWKYADSGVSLPPALASVLEDVHEKQYHRPDVVSLDMLIDIRHMTILYAGGAKVHLKRQAVTPPGTLRRYVCEYHFYAYTLPRLLSLQSAGNFSGSKFRTTRVVLRFISMTLLLLYALLVSGLILQAAFPQLRPLPVRVTAAADNSHLTFDHIVVRMHLLSQNASRRAAKANTSNSVLEGYLSGLPEAASSAFMWHNITSADNEDFYPQLCTRQYGETSVWELALLAVAPYLFNVEEFNTMLRFLNAHMGSDWVIQPRHGASCVPGDSNHQPTGWSDFYEVYSEQRDTSVIAVRGTDMFSFTDFLFNTNIFFEVVLYQLMTTLLPGTVVVPKDLIVDLLRTASLPADSYGDVYETWAELTRSGNHSLRRCQQNNFRRDFFADLYNHIAYVGSRPTHPRHLVLTGHSLGGAVAAIVAAQMRVKAVAFSAPGIALARKKFSLPLRSINENIMSVVSSNDIVPSVGEHGGEVHHVECLAATRELCHAMEFMIGSLWRSCSSVRARFPSIKDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S8D5</accession>
    <name>A0A088S8D5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_203660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIM50 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698568.1">
        <property type="nucleotide sequence ID" value="XM_010700266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S8D5"/>
    <dbReference type="GeneID" id="22574577"/>
    <dbReference type="KEGG" id="lpan:LPMP_203660"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200042900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_203660"/>
    <dbReference type="eggNOG" id="KOG1605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FCP1 homology" evidence="3">
        <location>
            <begin position="240"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="396"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="416"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN97861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="531" mass="59198" checksum="EACA9DEA5BE4AD4E" modified="2014-11-26" version="1">MSFSRPQRLPHKALRRSFCTSSLRTDRHQTRHNRNSFPRRALRVTHSTQCLLPGNADVDCKIEEVTIPYSVTTCTTETFVNFVKASGSDSEYSEYDLVNEQMQDFLLDSEDTSDADADMEDMLGMGAVFMSGFMPTGWEDAHHARVWRHSTKPDRRRMAKKSESCASLTNAARPSPSPSTTMLSDLDTAVKDAVAMGGTSQRHSTRRQRRAMARGEQRWLVPALSAIAVDTADGGGDERRQLPWFTVVFDLDETLVGARDGPIHLRPYVGELLRSLHRLPVEVIVWTAGSAHYVNPILHAIGQACGRRQWFHHIISRHKRWYRGSNMCVKDLRQLGRSLDRLVMIENNPISALPQPSLCVLLEDYLRPNTADKSLLVLKEVFERLAVQYARESRTTSLTDTRKQASEEDCPAPRPTDSSVNSLQDATTTPSTILPLPAPPSVALHVSDDAALQWAEFRMEDILNEDGVSMSQRAKMKELVGGADRLRCLCLCYTPPLQESFTAVAPPGATASVSSVSALRHYGSVSPLLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SAS6</accession>
    <name>A0A088SAS6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_241080</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98741.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699448.1">
        <property type="nucleotide sequence ID" value="XM_010701146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SAS6"/>
    <dbReference type="GeneID" id="22575517"/>
    <dbReference type="KEGG" id="lpan:LPMP_241080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240016800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_241080"/>
    <dbReference type="eggNOG" id="KOG0924">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000145">
        <property type="entry name" value="probable ATP-dependent RNA helicase DHX40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001369">
        <property type="entry name" value="Putative pre-mRNA splicing factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF91">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE PRP16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN98741.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1088" mass="119934" checksum="6AAD4E45781F9672" modified="2026-01-28" version="2">MDAVPVDRGIKRSREENVPDSTSPFPAAKDVAASIQDQVQNFFTRLEMGEILEHDHDTTEAVMTGADESAQWAYGSEYYLRHDGDDDKEHSSCSRTSGSAAAAAAAQERSSDTQADKARKVIVNLAMAPPPFFTSGNDFEASTLWRKPESTAHDTDDIDGDLDGRSADVTSCFLHEALRMSDVDVLVPVVSHSCSLAVSASKGSRALTALERLMDRERANRAVMDTSKSGLARLLQRDTYGRVVKEGETAVAGVGGVSAPSHLHSSSLSSLPEDRGIDGDGEEEEAKYLKCQVRWELERLAETTRLCGASDGSSSTAPATAAGAAELQWGSGQETRRQRKEDQLTRIEERKAQVEMLASTADEVERRAAMRRQCESLPIHHCKEELLRYIGESAVTVVMGETGSGKTTQLVQYLYQRGYARHGKMIGCTQPRRLAAIGVARRVSDEMGCALGTTVGYSIHLDDTTTADTRVKFMTDGVLLRETVSDPSLDKYSVVMLDEAHERSVDTDVLMGVLKLVLRRRGDLKLIITSATMDIRKFSAFFGNAPCYEIPGQTFPVKIHYSPTPVADYVAEAVFRVCQLHLQMPLEDKQDILVFMTGRADVYGTCELIRRRLTELSPQHLSTLLIMPCLSEAASACSTKIGVLDATPAGMRKVVVATNVAETSLTIDGVRYVVDCGFMKTNVYRPSIGMNTLQRYPTSQAQANQRRGRAGRTTDGTCYRLYTEEQYAEEMLPNSVPEIQRSSVDSVVLLLKSIGIHRLREFDFMDAPPAANVRNSMFHLWMLAFLDDTGDITEQGRQALEFPMSPVLARLLLESVKMGCALEVSRVVSMISADPKNLFELPKGREKVAQQHHSRFYSNDSDHLTLLHVFTQYVDHGRSRQWAQDHFLHAPTLARANDVCTQLMERLRKVHLPIQSCGHAGMDKVRYCLAKAFVLQAAQRSDRRWTEYRPLLNLGVTCAVHPASAVHARREMPPYIIYNDLLLTHKEYLVMVTAVEPEWLVESSRGIYEMRHSSTSSSAVTVVSSFATGTAVTPTPSTASRTSQGSMPSPLTAPSRSANSRTSVTAAAKASVKKSALGMLTPKRRPNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SD92</accession>
    <name>A0A088SD92_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ribosome biogenesis protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_280470</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700388.1">
        <property type="nucleotide sequence ID" value="XM_010702086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SD92"/>
    <dbReference type="GeneID" id="22576492"/>
    <dbReference type="KEGG" id="lpan:LPMP_280470"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280010100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_280470"/>
    <dbReference type="eggNOG" id="KOG1963">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4096at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000234">
        <property type="term" value="P:positive regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053826">
        <property type="entry name" value="WDR75"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="270"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN99681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="795" mass="86204" checksum="994FBA4FB14EA42B" modified="2014-11-26" version="1">MQSCFAACSQVVCVGEDTAVAFYAPKSLRKFRVERLNGSRVCGVYVKVISSTKAVLYVIDAEATLFEFVIEGGAPSLVRTCSIRLPPALVVTPTSARKHENALEVQPLESMGGTANVEAAATDSVVMVAQFHVQQAQLFAVLLTKAGVYEAALASATAAGATSAPSAVVVHVFKEPLSFGYLSVGQFTGLVVVAVPHAREFFYSLFTDRLSTHQPHRPSCPSLRPRAVNVQIQSIACSPTGTSVAVGGRRGELLIYVEVQEAHCFADHWHHTPLTALAFALDGSAVYTGGREAVLLIWDLVSYSHKKVKVQLGTLQRITPFSSAGSQLLLSCGTSTLAVADLLQMRVTTSAEGIEWTAEGVCTGLLVEQWGGSPAVILTGMPDVLRVCDPYTQQSIYSLHVSSQMETIPSPPRHGIQFVGLLNDSRSLVTYESFSSTVLPPLLRFWEYDASRKQHVETQTLYSPHRSAVLALAVEKRGQRVFTLSCEAMKCWAQTAFTTQDTYGTLSGGWHNHSTMATPSQQVQAMTLSADGSLCFVADDCLHVYSVQDCKPGERWPLLRLLPQYTETQPLRQIVVSPDCRHVVAAGKQQIFFWTLDRCADEPTVFSVGDSCITALSAFTDTTMVAALQDTSLVELCCCTTGSGKGPQLGEVVRRVRNASRFPLRHIVPLHTNGQRLAAVDAATGFKILQLPTEVTTAAQSSVYEWVNSSDDASGVGNGAEGDKTAQLQLQSFFKEMNSFQDSQEAMMTVHQERALATAQQTTQADRWLAEVLGEPAYTVPLMSTILSTYLQRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SEF9</accession>
    <name>A0A088SEF9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Dihydrolipoamide dehydrogenase, putative</fullName>
            <ecNumber evidence="9">1.8.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">GCVL-1</name>
        <name evidence="9" type="ORF">LPMP_291840</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="6">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="9"/>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700789.1">
        <property type="nucleotide sequence ID" value="XM_010702487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SEF9"/>
    <dbReference type="GeneID" id="22576947"/>
    <dbReference type="KEGG" id="lpan:LPMP_291840"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000008000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_291840"/>
    <dbReference type="eggNOG" id="KOG1335">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="361797at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050151">
        <property type="entry name" value="Class-I_Pyr_Nuc-Dis_Oxidored"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912:SF103">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912">
        <property type="entry name" value="DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="8">
        <location>
            <begin position="12"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="7">
        <location>
            <begin position="363"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="189"/>
            <end position="196"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIO00132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="508" mass="56403" checksum="AB86CC6897D5AC59" modified="2014-11-26" version="1">MKRTFFPLAKKFDVCVLGGGPAGIAAALRAYELGKKACIVEEARIGGADFWNGALQSKTLWEMSKFARYSMGNTSHRFMKSVCELPKIKHENLIKAITTSAETRESQTLEVLAKAEIELVFGFGFFKTPNLIGVAKKDGTEENVEADYFVIATGAQPRPHPTAVADGKVVFTSDDIMWQPLPKSIVIIGAGVIGCEFASIFANFGVTQVNIIEKSGRILPMEDEDIALFVQTLLENKGVYFHHHSAMESSNIEEGKFNYTLRDVRDNSLHEHVTDSALVSIGRVPMVSKLNLKTIGVKMENNHINRDDFLRVAPHKNIYACGDTCTRAALVNVAELEGRACIDHMYIPYPEEQLKLKLDNLSTIMFLDQEVAAVGLNEQQCQKMSIGYKMARYSYEYVGRALAMGNTRGFIKLVVTNDKRMQVLGVRAVGPHASSIIELASLAIHNCDSAYDLRNLHAAYPAITQAFQECLHMLLGSSILKPGVFPQLVVREWNPPHFEHGRSYAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SFW0</accession>
    <name>A0A088SFW0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2 domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_310780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701467.1">
        <property type="nucleotide sequence ID" value="XM_010703165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SFW0"/>
    <dbReference type="GeneID" id="22577504"/>
    <dbReference type="KEGG" id="lpan:LPMP_310780"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310013100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_310780"/>
    <dbReference type="eggNOG" id="KOG1012">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270970at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052981">
        <property type="entry name" value="Ingression_C2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47052">
        <property type="entry name" value="CONSERVED SERINE PROLINE-RICH PROTEIN (AFU_ORTHOLOGUE AFUA_2G01790)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47052:SF3">
        <property type="entry name" value="INGRESSION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="272" mass="29887" checksum="0731B180EDBD153C" modified="2014-11-26" version="1">MGRLEIRVCGARNVANLQKVGKPDPYVKIKVGDKKKSQIRYKTRVAENTLYPVWNELFKFQVADYDSTQVLFELWNDNVIVDDLLGHYSLSLNGLTRGVVVDTWVILVGTKVSSSELHLRILAADFGYDPQPGDRVVRSLEEDNITTPMYQIYRPPKNFSPQPQGVGLQSYPVAPLRPPQPLVYGAPVAPMPHGQCTYFATPPQPQGYSYGAAPAPPNYGYGAPSPPQPMYGAPLPPPQLPYPGGPSPPQIYGPPPPPPRPAQMAYGIPPDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SG18</accession>
    <name>A0A088SG18_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_311510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701542.1">
        <property type="nucleotide sequence ID" value="XM_010703240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SG18"/>
    <dbReference type="GeneID" id="22577577"/>
    <dbReference type="KEGG" id="lpan:LPMP_311510"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310021200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_311510"/>
    <dbReference type="eggNOG" id="ENOG502S1P0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275877at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO00742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="123" mass="14393" checksum="68632009A70E7863" modified="2014-11-26" version="1">MSADPEAPANPSRFSGGHIVRNMIYAHDENHNLEILSGWSEQGTREYDQETVRPANTNMDKSHPCFSLNQDLLRCSYRCPTEMKLGGRTATCNTERQVLMRCLVKNKQWRPSEADKRQWYRFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SHA9</accession>
    <name>A0A088SHA9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_323020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701987.1">
        <property type="nucleotide sequence ID" value="XM_010703685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SHA9"/>
    <dbReference type="GeneID" id="22578043"/>
    <dbReference type="KEGG" id="lpan:LPMP_323020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320036600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_323020"/>
    <dbReference type="eggNOG" id="ENOG502SMPU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267284at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008496">
        <property type="entry name" value="TMEM222/RTE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20921">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20921:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05608">
        <property type="entry name" value="RTE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="750"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="664"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="414"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="477"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="776" mass="81732" checksum="9BC784CC330FB1D5" modified="2014-11-26" version="1">MPSVAAMLSSSDHRENKFLSDHGTRSSSRADAVAAVSRSPTSPRASSFPDEGAVVMQSCDRHSPFTTDPTSPWLNCRSATTTSLDADDEADEQSPVNTSESAATPSPLAALALDYGHRQRTAIDSCQDTSQYVANCTGEVADVNPTTDTDQYVLERQQSTMPTDSAASGTNGSAAVQTVVRRRSTKRSPSFSSALLKLGGSGTMPCSTAASFPGVPPLSAKACASSVQSTSAATCGPSGEVATATRAPAASVASTDSVFPSQTYSLRADSDAIMNRSDSPSPPALTSLATATAKLLDSFPALHTSSVPLSPLGTELRLSSRTAVELQHFGCCVFFFPAPFVSWLFPLAGHVAISNAEGSRLFTFEASYYVREEKLVSVLDCVLREEVLEPRTTSLLREASPLGSRVELSQLPVTTTSRSPTSSQQLGASVMSDASASDAALTSPSDTSAGALLQCSATSSVFSSRCSARPPRRAGRQRSAAGASASGHAHTQCVRIWDLKPLLMESRGRRTRRTPSCFTTQGGKQAAVVLWERLQGLLQPSEISTSPVQGAATAGASTSTTSSLIRRTSNMKHRYTSGYHSDDADGIRSAPGMSSSSGEEEGGEYELLDAETARFYNRNLNATIRLFRGSADGSINSPDVVLQHHSSFSFVGFVLEACGVGSQGKPSSTVSAPKPPVKDEASGGNAVTPPKPSGDTNGPATAPASDDAVPGESLSSEEEIHWGVMKLLFHVSVFGKWHRGKRRLWRVVHGGSITSATILWVAIIALAYHYFELLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SJA1</accession>
    <name>A0A088SJA1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dynein light chain, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_342760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702702.1">
        <property type="nucleotide sequence ID" value="XM_010704400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SJA1"/>
    <dbReference type="GeneID" id="22578781"/>
    <dbReference type="KEGG" id="lpan:LPMP_342760"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340033700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_342760"/>
    <dbReference type="eggNOG" id="KOG4108">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10260741at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21459">
        <property type="entry name" value="DLC-like_TCTEX1D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255:SF70">
        <property type="entry name" value="LIGHT CHAIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255">
        <property type="entry name" value="T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO01902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="123" mass="14474" checksum="97A281B4FBA9CEA5" modified="2014-11-26" version="1">MQGEVDATTFSLRPDHQHKFRPNELKPIAKSVLESRLEDQEYNADEMQNISKEIADTVRDKIRSKNLERYKIIVHCMIGEQRGEGMRTGCKMFWDSDTDNYFEEVYVSKHLFATVTVFGVYQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SJQ4</accession>
    <name>A0A088SJQ4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PIH1 domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_344200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIH1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702842.1">
        <property type="nucleotide sequence ID" value="XM_010704540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SJQ4"/>
    <dbReference type="GeneID" id="22578925"/>
    <dbReference type="KEGG" id="lpan:LPMP_344200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340049500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_344200"/>
    <dbReference type="eggNOG" id="KOG4356">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5135119at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050734">
        <property type="entry name" value="PIH1/Kintoun_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012981">
        <property type="entry name" value="PIH1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041442">
        <property type="entry name" value="PIH1D1/2/3_CS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22997">
        <property type="entry name" value="PIH1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22997:SF0">
        <property type="entry name" value="PIH1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08190">
        <property type="entry name" value="PIH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18201">
        <property type="entry name" value="PIH1_CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIH1 N-terminal" evidence="4">
        <location>
            <begin position="64"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="PIH1D1/2/3 CS-like" evidence="5">
        <location>
            <begin position="320"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="428"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="562"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="572"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="592"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO02042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="635" mass="69670" checksum="DE96F9418A0C9AD7" modified="2014-11-26" version="1">MNPNDTAQQLLQNEKLLELFQQALGGDGGSGSGGDVADMLKSMPKESDPKREEWLRALQSRLQQETAKEAKKDLEQVHSDEYGQWMFVLPDPGFCIKTNVAGGVKVFINVCQHPRIGEPVPMEPDKENAGQEDSAEMRYRIPISCGQARPGQDKCGNPCKVYDVIVNPSTIQRCGNDHEFRRFVAALCMQWIKQKSEPTLNADEFRNLNFKCKGTLEPQRIRLSAQPKEHNAVGDEIRLPTAAGSATAPSQVIGSQGNGKLIQEVLPPNTTNANPSATATGTATPDTAALKLEPAVKSVTAEGAYNWTLHKRPASNPYFKENVPAHFVIAFHLPGVQTIREVDVRIGHRRVDCYYIDEVADGQEDDARAAASAGGDEGGTVVSKKGSGASPFLSLTLDYPVSDDVMEAKYVRKTSLLKLKLAVQLPDETQAPATRPERDVTEVEEEEQGRERAAREKERAAAKARNERQRQEEAAVMAERRSYVENLSMVQSGDIPPIIRDEVNQLPREQLPGMLHRLEGRIRKGDSVDALLDKLPEPMLDALIDYIREKLSLEPRPRTVLAAKGKDKAASPSDSHQANSASPVSLSAAKAADAEPSSKKASPESQTAMQEFNVTKQSEALLGVAFHNRYLFALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SK32</accession>
    <name>A0A088SK32_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">mRNA (guanine-N(7))-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_350120</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:67008"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.1.1.56"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.56" evidence="1"/>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702952.1">
        <property type="nucleotide sequence ID" value="XM_010704650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SK32"/>
    <dbReference type="GeneID" id="22579041"/>
    <dbReference type="KEGG" id="lpan:LPMP_350120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350006100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_350120"/>
    <dbReference type="eggNOG" id="KOG1975">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10248867at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004482">
        <property type="term" value="F:mRNA 5'-cap (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000618">
        <property type="entry name" value="Putative mRNA capping methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004971">
        <property type="entry name" value="mRNA_G-N7_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039753">
        <property type="entry name" value="RG7MT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189:SF1">
        <property type="entry name" value="MRNA (GUANINE-N(7))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189">
        <property type="entry name" value="MRNA GUANINE-7- METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03291">
        <property type="entry name" value="mRNA_G-N7_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51562">
        <property type="entry name" value="RNA_CAP0_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MRNA cap 0 methyltransferase" evidence="8">
        <location>
            <begin position="23"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIO02152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="323" mass="35644" checksum="E0C5377BB102DB12" modified="2014-11-26" version="1">MPKGQAAAAYDDVTRKRKDDWSSQQVAFRHFNNFVKKTLIQFSLDRVLANVAASASEGAAVLDIASGRGGDIGKWLYMQSSAQGDARAPSCSLHTTVYDCYDISPECISEAERRCKEMIATMERPSRCCASFTVADCFSESFLRGTLPSSPHFGRYNIVSIQFAFHYACRSLDLVRDVFSAVSSALAPGGVVLITTVDLATLSKRAAEGMMSNELYSITFPNPPEYTTVSDGSTLLVTGTEYHFRLEGFVDCPEYVVPYDAVVQIASEAQLCLCESMSKPFSEFVPHYSANWKANRGNRLSQAELELVTLYRTLCFEKPNVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SKM0</accession>
    <name>A0A088SKM0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Guanylate kinase-like protein</fullName>
            <ecNumber evidence="5">2.7.4.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_352350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the guanylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="5"/>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703172.1">
        <property type="nucleotide sequence ID" value="XM_010704870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SKM0"/>
    <dbReference type="GeneID" id="22579264"/>
    <dbReference type="KEGG" id="lpan:LPMP_352350"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350029900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_352350"/>
    <dbReference type="eggNOG" id="KOG0707">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6334211at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:GMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117:SF13">
        <property type="entry name" value="GUANYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117">
        <property type="entry name" value="GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="4">
        <location>
            <begin position="42"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO02372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="328" mass="36170" checksum="249781BC5DC707BA" modified="2014-11-26" version="1">MSAAPKTSTPTISSVAVASAAHKTARQAMEPLKDTVTLSRLVDVLLFLGPSGCGKSTVIQRLQRDWPMLFEFSVSHTTRCPRRGEVDGQHYHFITMEEFQKLIDSGAMIEYSRLCLPKTSSTTPPQSQPVGNLYGTSKKALHTVLERNRVVLMDTDLLGAISIRRYCAREVVNVRPVTVSRSKRSMAQQGGGAAPTVQSPLTLSTSSLAPVFLARERAVAPAGTILSTDATLSSPSCAAPGVTRTLRCMIIFIAPPSMKVLEQRLRERKSETEASIQLRMKLSCRWMKWATENQSFFDYYIVNDDLEHCYAQVKEIVQAEVLMLGSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SLD3</accession>
    <name>A0A088SLD3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_354810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703412.1">
        <property type="nucleotide sequence ID" value="XM_010705110.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22579509"/>
    <dbReference type="KEGG" id="lpan:LPMP_354810"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350056300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_354810"/>
    <dbReference type="eggNOG" id="ENOG502S7TX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267767at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="482"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="531"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="618"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="710"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="977"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1129"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1211"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1336"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1390"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="710"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="728"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="755"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="788"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="836"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="848"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="977"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="997"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1038"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1079"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1129"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1151"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1404"/>
            <end position="1418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO02612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1791" mass="190009" checksum="21AA26939A2CDEAA" modified="2014-11-26" version="1">MRRAHRHSDGHGVGGVMSDASAVVFAAEEAACTEPQKFISADRNLSSDAGYCHGSANDAAGQATLLELLWRRVDHLISDISYTIEERFIIPQKISAMPGLIEEEVTHRRSFLVLVGHFISIVIVMVIAAYSHRLSHLMSGVSPVVGEILFCASHLSQVTQEQLGWSLFCNGFLSFSTRDWAVVEGGVSGGVVMSNGAAGHGSKRQMLGAIGGGGIGANGALAGGSQGWAGMGSGGAGGMMVCPNTGGSLVRYLLGRKANNMIRHEPLRSYLYSSFYSPSAFLVEQTAWFVLLATTMDVVTMQRLAVAVFFANVVGWLPVYSVKLLARLGTALAVVFIFLIPFYEVDDTVTFTLVHHSVYHVLSAYCASLCITLLFAETLLFDDVRRVLVQGVVTLPQRLLRVAGHLSVVTKLVRGCMWLRCEYLYFVDFYFFLGIMCWLSLVLMETGAGISVFATAALVITVPSLVGNGWMATPMRALKDTVIYVGFYVVTALLLFHVVPWSGLAFLSNAVQSAAVLLLMAARCEYKQPGGSAYLILWVTMMCVYMYLKSSATRGMSRSLVWATNNSNSRANFEKVTHAVWYGVPEVEGAVFDLLRIVFIAFWQFLFKGLSEEGVQLLHFNVVVFGSMLLLSTAVRAVVVEGVRFSSPGQWVLPSAEATSTPAAASTPTSATVAAMKGEHNVGAAQVFPGRDSSSSSRGVSNALSCSAPAPSSFAKSKSTQPCGGAKTSSLSTASSARRSWQAPSRTAAADGNTYVGGAGRGGAATPGVAGSEETVTDTRVALIKTTNEGKEAAREVESVPRGGGGEKSTSPASSAAMDEFVTEDERAPAALEGGTVTSRTPQTSECDAQKSKGGGDPKKQSFRPVTASVAQNRCSAETVDETAAQKRTHPQPICTLDKSSEMVARVFQRDASNIFKETSRSASLEESMNYNATVLTSSICRSDVSSTTPFSLHHEHSTCFTSRSSTTVEILWEARRERHEEDREKVPLREQERPKTPSSTTSGALSTPHSMTTTECEGEEQRRQTSKSSLKQKKTPETGTMTCSSQGTVLPLPRSRVEELKVPGVPMTGPSANSRQSDVTEGKEAVRGKKAVADARAPGASAGKAASLTALTVSADSASAAVVIETGPKDDRGKAARANSEGKKADGKVKAAVGKNAKSKAATESPAGDEKVVAPTVTQWPAPFPLPKPRHEQTAAAEASATVIVKAPAAAGKSTPGQTANGEKCGKKATVPTMSNKEGVMNTRKAAAAAPERTQTLAGAAAATASSSQSVMAAPAVLPVPLPRSAQVADAEGTVQSAQTPVESGELALEEPVQRPWRDARWANAVSRLSLAVETDGPAWEPASEPKQEVKGKHSAALTADDGEEPDDGYDLDGVLSFLRLKVDYSSVMDDEEDRSNSVSSNADDRHNPTSFRHFESPEDSTVAVQTPLTNGHVVKCGLSGSTDSGVPANVFSTVPQPHDCVNSAHGSLALAQPSRSESLMESSQDTFQAIQSAPEWTAKGRSSFGDLCTNSVASANNNITNASGNYVPNGASSPGFHVFSIHPTATGISTAASSSLSPQPQSVHMGIASHGSAPLFPVAMESCMESSVTAHHIDFNAAGTSFGYYQVPQVAVPPSPPMDSRQSSSSHMPFSVSTVNLSASPMSSLSSLGRTNTDTGIDQNGVLSRLHVIPNSRMAMSEQMAMQQSPQTMMVMMRTPDGQMGLYPMVYNQPMPLLDASGLMQQTQRAQVTAQQQQPVYASAPLLQGHSGMVGYQIAPDGSYVMTTTSEVLQQTMNQHQQHQEPHQRFCYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5M2</accession>
    <name>A0AC62A5M2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1620740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="XUY37085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="990" mass="107840" checksum="43B9B5205B43A328" modified="2026-01-28" version="1">MRQLIDRRSFPHEVVPVLDTGTDTHSRRRKRRAAARAIPFVFAGIVALLVFGYIFETTFPSGGVRSGGAIRASTQKAEDEIIGQQLQGATSRHEEQWTSSPPDPPSTKRTTSSTAPASTTGTEATKASALSGVPPSTLHPVSPTLEAPDPLHKPNSQPTFELLSSSQLPAPHSAATVHGTKANNATHTVTKDLYPTLSPPSGHVRSSPTPQTTKRPQLQETRGEYSPEEAQRLPGLQIQRRTFTPAELLTRFGDTDIVYSFVNGSEVNHEYRKAMVKYCIDTVLLAENASYVMGPTLLVPTPDPAELPSRATASTQGTRSHPLLGSDHCTRAFFKGGLDRIHTVRDFLRAAEAAARSGVDNRDRETDELRHSLRSLEQHVRWHRGRVVVVSPGHHPTWVDGAKNFLAGLCGDARVQALRSSGTHLRVTTVHQDAVMPYGMRLTVDSHVIEQHLWRVRNMTAVHVYMNDDYFVNRDVAITDLFNEYGGTIVRTENGVISAGAVADHSASWAKGVRHTQQFNIRELDVLHEDYLPEALATMWDRLRRVHRGGHAGAEALISVPPLDEAVDVAHQYEPDPLPVTPLLPRRLRRYATHAPFVYCTNMFRFFETRYEREFAAAALRHRSRKARDLFVPFLYNAFIMARPWQASPRFLPYLLELHRSRREARTDAMPPTQIVLDNFDGCGPASLRGGFVASECMFGKFGNNLKENEAVMERVRKTNPLYFNINAGLSTAEAAAQLRSFLHGKFPTPVYLEVGGAPAAGEDLAGGAEEGALSRLFGDLMALPVVCVVSYEEGVCPLVRSLALAFAGHHRGGVRVSVEQHGGATLRETRAALGHGVVSAMPAPACTYGERVRVGPATGGEGISVIARRALDAMGGGVELPATCGGGGAGLRVRGFVVDARTRGVPVRSAAALRDALAAPAQTLSLEDFRAVAVGPSERDVVLVVSREDADAKAVHWVNGASESDLLVTYPLPVEAYEDMGAELLWSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5U3</accession>
    <name>A0AC62A5U3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histone H3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1620490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="XUY37060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="66" mass="7238" checksum="D87F239EB5F19D1A" modified="2026-01-28" version="1">MPCARCRACRRRGGPALPEQRDPGDPGGVRCVADGCHEPGQHPREACVTVRPKDVQLAVRLRGERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5V6</accession>
    <name>A0AC62A5V6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histone H3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1620640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="XUY37075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="66" mass="7238" checksum="D87F239EB5F19D1A" modified="2026-01-28" version="1">MPCARCRACRRRGGPALPEQRDPGDPGGVRCVADGCHEPGQHPREACVTVRPKDVQLAVRLRGERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A652</accession>
    <name>A0AC62A652_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amastin-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0820090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="XUY37289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="187" mass="21250" checksum="68964CA9A4383FB9" modified="2026-01-28" version="1">MEFTLVFLLYAVVQFIAFLFVLVATPLDMLYDKNGSRFDNRPCVTLWGTKDECYGLTYEMTSDEVWNVCPVRRNRFRAAQAFAIISIFVYGLAAVLGFILLWCCSHLRFVCLALNVTGIVTVGFVWASILVTYYKTEFPCLRENLYTVLGSGFVLLVMAWCLDIINIVLLLLPWQAAHPSESGETKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6F0</accession>
    <name>A0AC62A6F0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amastin-like surface protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2021090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="195" mass="21821" checksum="4422187F17640540" modified="2026-01-28" version="1">MEFNPFIIVYAAIQFIAFLLVLVGTPLDIFRSRQRSIFNETSCVLLWGVKRNCSSIAYAATSDDRWVMCPTRRTHFRVARVFAVITIGVYCAAFVLGFIMLCCYACLRWVCLGLNIVGFVTLATLCALMVVSYETDAYPLCPKLKNDFTLSSGFFLFAAALCLDLVSIAFLFIPWSHENVEGSSSHSKEGNSQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6G8</accession>
    <name>A0AC62A6G8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amastin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2020390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="218" mass="24182" checksum="DF79C29B62621F4A" modified="2026-01-28" version="1">MEWNVPILIYAIVQFIAFVLVLFGTPIDMYRFRPRFITPDTTVTTLWGVKKGGFNSTNVISSDFLWRRCIVRRDRFRLAQAFAVISIFVYGAAAALGFIMLYCCSFFRMVCLALNIVGAVTLCIVWAAVAVTYHIEDNEFCRKESVFSTYGAGFVLLLLAWLLDLFNIVVLLLPISIAAGGAGGSSSKDSKKQDESSNGHSRESSMEGSRQNDLSEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RH67</accession>
    <name>A0A088RH67_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Par3/HAL N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_010140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009370">
        <property type="protein sequence ID" value="AIN95115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696657.1">
        <property type="nucleotide sequence ID" value="XM_010698355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RH67"/>
    <dbReference type="GeneID" id="22571743"/>
    <dbReference type="KEGG" id="lpan:LPMP_010140"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_010140"/>
    <dbReference type="eggNOG" id="ENOG502S6I2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10248873at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN95115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="9025" checksum="2B418BC1FD27199A" modified="2014-11-26" version="1">MKIVVHVREKIIPLQCGDGTQEVVWLGNAALIHYDASFGKRFGPPVLIHKEGGVPCDLGARVCDLLEDGQHVFITLECDRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHB8</accession>
    <name>A0A088RHB8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S acidic ribosomal protein P2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_030380</name>
        <name evidence="7" type="ORF">LPMP_030390</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">P1 and P2 exist as dimers at the large ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009372">
        <property type="protein sequence ID" value="AIN95273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP009372">
        <property type="protein sequence ID" value="AIN95274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700981.1">
        <property type="nucleotide sequence ID" value="XM_010702679.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700982.1">
        <property type="nucleotide sequence ID" value="XM_010702680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHB8"/>
    <dbReference type="GeneID" id="22571904"/>
    <dbReference type="GeneID" id="22571905"/>
    <dbReference type="KEGG" id="lpan:LPMP_030380"/>
    <dbReference type="KEGG" id="lpan:LPMP_030390"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_030008800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_030380"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_030390"/>
    <dbReference type="eggNOG" id="KOG1762">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267775at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05831">
        <property type="entry name" value="Ribosomal_P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696:SF6">
        <property type="entry name" value="ACIDIC RIBOSOMAL PROTEIN P2, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="67"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN95273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN95274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="107" mass="10882" checksum="C4416EA8524BCDC1" modified="2014-11-26" version="1">MSTETLACTYAALMLSDAGLPTSAENIAAAVKAAGVSVRPTMPIIFARFLEKKSVEALMAAAATQAPTATSAAAAPAAGEASGKAEEKKKEEPEEEGDDDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHG8</accession>
    <name>A0A088RHG8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Splicing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_020100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009371">
        <property type="protein sequence ID" value="AIN95190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698155.1">
        <property type="nucleotide sequence ID" value="XM_010699853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHG8"/>
    <dbReference type="GeneID" id="22571820"/>
    <dbReference type="KEGG" id="lpan:LPMP_020100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_020006000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_020100"/>
    <dbReference type="eggNOG" id="KOG0227">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250970at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2690:FF:000007">
        <property type="entry name" value="Zinc-finger of C2H2 type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052092">
        <property type="entry name" value="SF3A2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031781">
        <property type="entry name" value="SF3A2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205:SF0">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16835">
        <property type="entry name" value="SF3A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN95190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="237" mass="26944" checksum="3A4588DEF8A507E9" modified="2014-11-26" version="1">MASSPNGTANLYDPIEVARANPYFKRNHMGQVTCTLCGIYCPEENNFLKHIAGKTHTLQLERRQHKELRHLRLQEEERLNTEAEERARKEEALLALSGGPVAGSSTDALSSATAAAAANARFGTPLYSFRTEHDEVAYRTKVWVEVIFTQAEEGTRPLHRWLSAREQHVERPADDYFVYLLFACEGYATIALKFPAKVNRSQPRDVLEETDGSTSEAYWCSWDPLKKLYSLFFVLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHN3</accession>
    <name>A0A088RHN3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GPR1/FUN34/yaaH family</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_030350</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009372">
        <property type="protein sequence ID" value="AIN95270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700978.1">
        <property type="nucleotide sequence ID" value="XM_010702676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHN3"/>
    <dbReference type="GeneID" id="22571901"/>
    <dbReference type="KEGG" id="lpan:LPMP_030350"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_030008500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_030350"/>
    <dbReference type="eggNOG" id="ENOG502S20H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015360">
        <property type="term" value="F:acetate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071422">
        <property type="term" value="P:succinate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047623">
        <property type="entry name" value="SatP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038013">
        <property type="entry name" value="AceTr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30178">
        <property type="entry name" value="INNER MEMBRANE PROTEIN YAAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30178:SF3">
        <property type="entry name" value="SUCCINATE-ACETATE_PROTON SYMPORTER SATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN95270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="33383" checksum="F077F9CEF0982B4C" modified="2014-11-26" version="1">MSAVSIPCGPLGYEPVEVASNPDLRKFHEKYSNNNLSSQVPGQQHPPRGQKNGSAIRKPSLLLKQQRLRELQEWEYQAAIAPRRTANPGPVGLLGFGLSTILLNLHNTGRFPLSTVIVAMGIALGGGAQVIAGLLEWVRGNTFAHVAFTSYGTFWLSLVLVWLLPNTAARSSSIVEPASEYFVGVYLVLWGIFSFFMLMCTIRMNVAIFIVFLTVTLLFLMLGFANMTGNQTALRVTGYEGVICGSTALYLAFAEILNEVWDRTILPVIPMTQLLDWLGVRRQKPEEVTGLNSSVPILKNDGNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RI36</accession>
    <name>A0A088RI36_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUDIX hydrolase dihydroneopterin triphosphate pyrophosphohydrolase/hydrolase, putative</fullName>
            <ecNumber evidence="2">3.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_050090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="AIN95450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703772.1">
        <property type="nucleotide sequence ID" value="XM_010705470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RI36"/>
    <dbReference type="GeneID" id="22572087"/>
    <dbReference type="KEGG" id="lpan:LPMP_050090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_050005900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_050090"/>
    <dbReference type="eggNOG" id="ENOG502S15K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276276at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000112">
        <property type="entry name" value="NUDIX hydrolase dihydroneopterin triphosphate pyrophosphohydrolase/hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="178" mass="20032" checksum="59E33DB1E2B5C850" modified="2014-11-26" version="1">MYRPNVCVFIFNEKVEFLGCQRMKTNHFQCVQGGIEACDMDITLAALREVEEEIGLKPSDVTFVQEIPPPNGDPMSFAYTLAPNANLRRFGYVGQKQRILLFFTASENIAKMVLIPPPELHALQEFRKVEWMPIEQLIGKALPEKVHIFKAVGEVAPGIARAFLEKNLLGEPKEAAKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RI45</accession>
    <name>A0A088RI45_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_060680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703949.1">
        <property type="nucleotide sequence ID" value="XM_010705647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RI45"/>
    <dbReference type="GeneID" id="22572274"/>
    <dbReference type="KEGG" id="lpan:LPMP_060680"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060012600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_060680"/>
    <dbReference type="eggNOG" id="ENOG502S0B7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5314041at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39666:SF5">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39666">
        <property type="entry name" value="RANBP2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="647"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="420"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="486"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="424"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="487"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN95627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="748" mass="76543" checksum="4FA0669DD069216F" modified="2014-11-26" version="1">MPNAVVTLTIEKAAGLVALNPGGTSNPFFTATIGAQCVTTPVVNKSLNPIFNATFTFHDCPLPAMVTLRAFNKIQYIDVEDPLGTATVTLFDVQPETTTKVVQLSHGGIAALAQRAPNGCGAVTVAYSIAPMPAEAAVPTVAENSASQLSSLPSSTAAPQTSLAVVTPISVPAAHNIDGNGPASIPVASVPCKDHAGILGSVTHDSSSSLLASNPSATNPTATTARLQPIEGTTAAVMEGSDAFTPMLDAMQQQRAHLTPPNLTPARPPANSTFFIPQVAPPPSSLAAVNMSLKAAPINGYESYAVHGVKPPPPVSEEAAAAANPVLPSMSAEFYYANNTAHNAPAAPLSGAAHAQSSGSFVMLPVASAAPAAARFASLQESTSAALSFDTQMQTSSASSLYTSAAQAPTSASQTKLLVIPPNINGTPTPSFLQTSRASSREISRHPSVAQFPASSGNLITSFSADALPPPPLVGALPVAVPPLSPPLSSSTTGSLRSTPAALSPQRQSNSVAFVASPLPAETSVAAPSSTSTRAVAAHRGVAPAFTATGARGAGAGAAFPYSATRCDAYASTSVASGTTSPKRRNPRSEIQLGTEAFAITSAAQIYADKQYLFEVAATGTNIEVFQRLRQVDPSLTNGFLECLDYSGRSLLHIAAWNGQLHVLQVLLCPQPAEPMIDLRSVVAAKSGNTILHAAACGGQAEVAQWLRYSHPTAGPLLLSMHNARSMTAAECAMEAGFPHVARLLMPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RI96</accession>
    <name>A0A088RI96_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Carbonic anhydrase</fullName>
            <ecNumber evidence="2 8">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_060590</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="2 8"/>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95618.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703940.1">
        <property type="nucleotide sequence ID" value="XM_010705638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RI96"/>
    <dbReference type="GeneID" id="22572265"/>
    <dbReference type="KEGG" id="lpan:LPMP_060590"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060011600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_060590"/>
    <dbReference type="eggNOG" id="KOG1578">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10248475at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00883">
        <property type="entry name" value="beta_CA_cladeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015892">
        <property type="entry name" value="Carbonic_anhydrase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002:SF76">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00704">
        <property type="entry name" value="PROK_CO2_ANHYDRASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00705">
        <property type="entry name" value="PROK_CO2_ANHYDRASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN95618.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="388" mass="43094" checksum="A689F0EB06D1F60B" modified="2026-01-28" version="2">MHMFAKPFALCSAGAPRRTAGATAGAASMLASAAAVAGSRCTHTRATHPLDLLHRQNYRVRQVAEGLSPSSDLLATLPCSTPMSLCSCGCPHPTKPTLGVPCMSFYTTPELLRDRSLSKSPATETQVKEELASLVGGRLVRSVQREQPPRGSGIQPLLDYNKHWAGEIVRLNPDYFVELAKQQKPQYLWMGCSDSRVPANEIVGLYPGDIFVHRNIANIVCNSDLNALAVIQYAIECLKVEHVIVSGHYKCGGVTAALHEDRVGLADHWILHVSAVKKRHWRRMLADLPMRNHLDALCELNVLAQVEHVVETHLVQRVWTQQNAEDAAAQRENRPSRNRPVDEVEIHGWVYGLEDGLIRPLLTLNRRSNVEKELHKAADALFWRYGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJ21</accession>
    <name>A0A088RJ21_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleolar RNA-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_071050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009376">
        <property type="protein sequence ID" value="AIN95790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704112.1">
        <property type="nucleotide sequence ID" value="XM_010705810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJ21"/>
    <dbReference type="GeneID" id="22572440"/>
    <dbReference type="KEGG" id="lpan:LPMP_071050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_070015800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_071050"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.340:FF:000009">
        <property type="entry name" value="Nucleolar RNA-binding protein, truncated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.340">
        <property type="entry name" value="Nucleoplasmin core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041232">
        <property type="entry name" value="NPL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17800">
        <property type="entry name" value="NPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoplasmin-like" evidence="2">
        <location>
            <begin position="4"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="329" mass="34829" checksum="A95067A0DA517DC1" modified="2014-11-26" version="1">MEGFYGIEVAAGKQVKAKIPEECALRVTQLAVPVNAAGAVSFVVSFEGKLFTIATLDPKRGVYQMSTDLVFTKAQDVSFSAQGAGAIHVTGYVQPIGNDDMMMDAMAGESGEEDDNEDDDDDDLEEMSETESNDVARAPASAAAGAADSDDEEEDEENDEENEEDEDDDDEDGEDMPPADLDDSDLGEEDEEDDEEDDEEDGEEDDEGEDDDDEDDDEDDDVPQKFQRTDRGGRGGDRGGFRGGRGGDRGGFRGGRGGDRGGFRGGRGGDRGGFRGGRGGDRGGFRGGRGGDRGGFRSGRGGDRGGFRGGRGGRGGDRGGFRGGNRGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RK36</accession>
    <name>A0A088RK36_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial</fullName>
            <ecNumber evidence="12">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LPMP_050980</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 12">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Mitochondrion inner membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="12"/>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="AIN95539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703861.1">
        <property type="nucleotide sequence ID" value="XM_010705559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RK36"/>
    <dbReference type="GeneID" id="22572176"/>
    <dbReference type="KEGG" id="lpan:LPMP_050980"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000032600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_050980"/>
    <dbReference type="eggNOG" id="KOG2658">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="42889at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.230:FF:000001">
        <property type="entry name" value="Mitochondrial NADH dehydrogenase flavoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.600:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11540:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050837">
        <property type="entry name" value="ComplexI_51kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011537">
        <property type="entry name" value="NADH-UbQ_OxRdtase_suF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054765">
        <property type="entry name" value="SLBB_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01959">
        <property type="entry name" value="nuoF_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010120">
        <property type="entry name" value="PRK13596.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE FLAVOPROTEIN 1 NDUFV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22461">
        <property type="entry name" value="SLBB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="Nqo1 FMN-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142984">
        <property type="entry name" value="Nqo1 middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="Nqo1C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 12" id="KW-0288">FMN</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 12" id="KW-0520">NAD</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding" evidence="13">
        <location>
            <begin position="350"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIN95539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="481" mass="54459" checksum="BB17B774F372149A" modified="2014-11-26" version="1">MRQGFLRPSAALMERVHGQLRDQDRIFTNLYEDFGTGINAAERRGDWYRTKDILLKGHDWVVNEIKASGLRGRGGAGFPSGLKWSFMPKKKQDDRPSYIVVNCDESEPGTCKDREIMRHEPHKLVEGALVAGFAMRARYGYIYIRGEFYNEWRSVDNAIHEAYEKGYLGKNACGSGWDFDLYTYRGAGAYICGEETAMIASIEGGQGKPRLKPPFPANVGLYGCPTTVTNCETVAVSPTIIRRGPQWFAQFGRKGNAGTKLFCISGHVNRPCTVEEEMSIPLQELIERHAGGVRGGWDNLLCVIPGGSSCPLIPKHICDNILMDYDALKEAQTGLGTAAVIVMDKSTDVINAIERLSQFYMHESCGQCTPCREGSPWLDKMMKRFVHGNAKKEEIYTLWDVSKQMEGRSICALGTAAAWPVQGLIRHFRPLMEERIDRFWEANPHWGKSGSPWRRWKTHRYYTLQKGDRLNWDGKIVRNWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKA8</accession>
    <name>A0A088RKA8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_110440</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696893.1">
        <property type="nucleotide sequence ID" value="XM_010698591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKA8"/>
    <dbReference type="GeneID" id="22572909"/>
    <dbReference type="KEGG" id="lpan:LPMP_110440"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_110006800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_110440"/>
    <dbReference type="eggNOG" id="ENOG502S6M7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266138at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF56">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="197"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="492"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="561"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="420"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="206"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="249"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="313"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="498"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="568"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN96240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="604" mass="65113" checksum="0E17953144AAD012" modified="2014-11-26" version="1">MQVDLQRRGLQSFDPAEFANTDEHLNLLLQVRQLDLSHNSLCTIRGLEGLTHLTVLNISHNGLRSLGGGLPLTLRELDASHNSLVSLQNAALLPLQFLTSLNVSFNDLEDLRGVPSVTARLTYLDARSNRLSSLVGIEHCSQLRTLHAEANLLREVADVASIKCLPLLSAVFLSGNPLLLRKRRLTQLRLLLPSNVEQDDLPTTAPPSSLRSSTAAPPSVPDTSSVGSLDHTTVASVSENREEVHCGSGHTSQPASAHQGTPPSMHDAAVTRDSSAVLEREPRQYVHSSASRRHHHLPYQDMSDRVRPSHSFAAAPPTTTGPTIATGVVGGASDSPTCPRRPLPHEHRLAETPGTASMSSSPDHAHATLTPGPLHSRNSRGSLAASLFPVPTSPPHEHGTVVTAPQPTRYGDSRSSDLARENLEVQLVRVTAERDHYRHEVVALRKELGELRQKCAQQWAHERTTVPGGLEQRCVRSAVAAAPVHEEGNLIAGHSEPRQSPQQQQPGGSPPGRILAVEMSAHSSFCSHDGEGDTPEAPTNNHLHAPQDKNLVGRARASLSPLMPLHAPQQSDTTSTSMGTSKMNRRKMAALFMAKLQQSGPSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKE9</accession>
    <name>A0A088RKE9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_130730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697155.1">
        <property type="nucleotide sequence ID" value="XM_010698853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKE9"/>
    <dbReference type="GeneID" id="22573183"/>
    <dbReference type="KEGG" id="lpan:LPMP_130730"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130011600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_130730"/>
    <dbReference type="eggNOG" id="ENOG502SIEN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267720at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="590"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="648"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="714"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="595"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="667"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="714"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="867" mass="92409" checksum="14DC0C9917308614" modified="2014-11-26" version="1">MVDLAEAQVPMNISDAAAMRAAAHHLGEPTHSRRRHHHCRRSSSPSKPRHSRRSSSAAAAMASASYLTEELHFDVQARETQRANERRRGQRYASSASPPGLDANQSYNCASGARFCSTATSWHSLTPDIQWIPYLLKDDSEEHHGHANGRRDESSGKGAHIGSDVRVNAQPPRAVLQGAARSAAVMIVGMRHIREALLATAVATTTVSADDTGRSSRHRSRRGRHRSSSRSRSLYARSDSVSSDASAEASLDSTPRSYHRPRRQSQEERKTREWRRRESREAHRQQFSTVVPLDGARHSSTPNSLHGLGHIKGGELPSTSFASTALPSRSQRRSSGVGGSRLATTAAATETAASDGAWVYPAPPPSERVHIYPCAGERGHDSEYLVGNGGSATVELGAAVSPLRYHQYSAATTDASTTATSFHVHRKLEWRTTETTTPVQVNIRVIPADRPAESKDALNRLKNESTSPTSLAQLVAQRTASPRTHSRLPPSYSPCSAAVATARSASQVHETPLTHEEAEARLHIVMAHSCQLVRILCDHYERLRELEWESKQHLLATTIRAAAGEDGAMPVAAAAPVTAASIMTSATVPNNTAGPVNSPSPTQSSPSLSASTVSAHTEMSSEVAMSPSAQIPSTPTTAGAAEILDTYAPSSPSLRQQPEWEKRSTRSSRTSPAPSSAAASYASQFPARPLSAHHVSPAALDDGSAAGALTTSPAAAAAPKVPASTGAPAPRLPAHESQLLSPPPVRSWASSYQQRIAATVVEEYAECTPPMARQAYSRHSHGTTCPLLSPSEESAEEVAEESATSDFGYKIAAVSTCRKHSTHYSTDSSSSSSTATYLVAENVELRASSGTATITTVSTVTANDPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RL06</accession>
    <name>A0A088RL06_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_130860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697168.1">
        <property type="nucleotide sequence ID" value="XM_010698866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RL06"/>
    <dbReference type="GeneID" id="22573196"/>
    <dbReference type="KEGG" id="lpan:LPMP_130860"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130012900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_130860"/>
    <dbReference type="eggNOG" id="ENOG502S38P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267037at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="652" mass="69136" checksum="00C9473B3A449789" modified="2014-11-26" version="1">MLRRVRGTAAAVRHVVAVVPAAAPPTSPGMTQIRSSWMQGPRKFSSYPFASPLSQCSQPVQQQRCGYTSRSGEEKGSAGKGKQAPAAAAAAVSTTPGTASTTAVHYFTTNQNNADLAAHPQSNVEQHKQAAAAAANGSAAAPSGIRTIGIKLTEDDELVRAFNSFSKNINGCTEEEFLVGAKQAYYSLAVVISAFVDHAQPLVGKTEPSKTIAAAHEAVKLLDKAFKPETHADAAAATASLTSKDEEGGDKDAFSTSHKKKLQDSLVHSVVSTIVSLIPVSRHLAESIFKVWVQHKDKQVNLSSIASPADYVLDSKLVIFARLGKARMYFNSDNVGAEVDVTFNNDYLRKLDPSDVAGSGAAGSAQKADAGGKVDEDEFDTGMIQVHTDTDANAHRTVAEEHTFVVNSATRTLVPTASTTASTAAAATTASADEARHSGKKSACAGPGGASAVESAKSSGTASRVQVTYVKPKGFSEKTADTATVPDEATAKAAAAPKESLEEEEEGHSVYIKVNGNMLPPIPASAHACALLTVDVVVPPERYAYNFEWFYKRIVGYENEYERIAAARVFASNSPKALASLLDFLMRMVTGKPVEFMFSKAIGRMIGIPDDVSRTPPATRKLMCMYMDQSYKWVLADLVTLAPVMETKLPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RME2</accession>
    <name>A0A088RME2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_161450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN97020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697673.1">
        <property type="nucleotide sequence ID" value="XM_010699371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RME2"/>
    <dbReference type="GeneID" id="22573724"/>
    <dbReference type="KEGG" id="lpan:LPMP_161450"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160020000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_161450"/>
    <dbReference type="eggNOG" id="ENOG502RXDH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271898at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="601" mass="65967" checksum="8F0AFE162E7A02CF" modified="2014-11-26" version="1">MGVCCSKSKHSNVGKHTKTKEHAAANSSFKSMQSTARRFQPIAFDVVVPEDANTTAISPHRGTRDADGEVNNCSGTLSDASLHTMRDTSVAIERSGNIYDPMSETLNNMNFTNSFRAVDRTAVQKFMRSVARLAERSNNKGTLLEESMLNASMGLETSVANRSILGGPNTSTILQEDLDYIAAGATLPDRMARLEEVERLLRRSIEGSWSVDSMLMQLACCQIVPTLRQRRRPWSAGKSAPQNQSTGAQRKSKRQPVLVIYAQGLQMDASISMPPASVTPSRTSPTIPSELPTFNGIDGKETSANNPSLVLSRSRSRLSVSPAGTKVQQYEMLALMCRDIDPHKVDTALVENDTWDFLSVKSATAALNEGRCIFRFMCGSLAEADSETMGIVDAIINLSSFADEVTENNTPKVDVHDSEDMTKYIGIHVKAMYMLPGIMLKDITKSLVVSTEYQKACQPSENKVQDCDIEDTFRLTLTVIRFVFSLTIQFKVSEITDPAVLLSLSVCDGIVPGKAIMLERTKRNIEKVDATAKVRSLLLYYPVNDGVLVNNHTVVLNTSLPKVVSKIMNTFGSHGAAQSVQTAKLTREYLLKRFGDARAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMH8</accession>
    <name>A0A088RMH8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">ATP-dependent zinc metallopeptidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LPMP_180510</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697885.1">
        <property type="nucleotide sequence ID" value="XM_010699583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMH8"/>
    <dbReference type="GeneID" id="22573941"/>
    <dbReference type="KEGG" id="lpan:LPMP_180510"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000045700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_180510"/>
    <dbReference type="eggNOG" id="KOG0731">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8120271at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005745">
        <property type="term" value="C:m-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000277">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050928">
        <property type="entry name" value="ATP-dep_Zn_Metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655:SF26">
        <property type="entry name" value="METALLOPEPTIDASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="131"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AIN97232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="600" mass="65132" checksum="F58EF8C1F4917E4A" modified="2014-11-26" version="1">MEMSSAGAQSPEYQQGVSDAERHRRATEENWIRPALGPIVWLGVPFLLAWLHMRRVSLGSPFGSRSPSGSGNPFQDMMAQMMPIKKRQFRVDVKGTRFSDVVGIPEAKAEVRQYVDFLTEPNKFTRLGARLPKGCLLTGEPGTGKTLLAKAVAGEANVPFFSCNGADFIEIMGGSGPKRVRELFEEARAAAPAIVFIDEIDAIGSRAGKQGGSVSSEENRTINQLLAELDGLSTSADPIVVLAATNFQDNIDKALLREGRFDRKVAIEMPDLAARRELFEHYLSRICTGDPNGRTKDEEGRDLVLDTSVSNKALADELADLTPGLSPATVATVVNEAALQSGIAGKPLVQLPDLLEALDNTLMGRKHRNRQSDQSARRTALHEAGHALAAWMLPTVQKVLKISITPRGNAMGYTQRAGTEFHEYQTNATLFADMVVMLGGRAAEEVMLGDVSAGAMDDLQRATDVALKQMLAFGMSTHTGLLSYHPDYTQAGRDFTTFSNDAQYRAELEAQKLLAAAHSTAVDIIKRHKDKVEIMVKALLEKKELSTRDIEQLWGPRPSTPTVEDIVHKVIEVTGSYAEIAATVGPTAAAVVAPNMARVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMI7</accession>
    <name>A0A088RMI7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Serine peptidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_121020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009381">
        <property type="protein sequence ID" value="AIN96429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697082.1">
        <property type="nucleotide sequence ID" value="XM_010698780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMI7"/>
    <dbReference type="GeneID" id="22573108"/>
    <dbReference type="KEGG" id="lpan:LPMP_121020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200066700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_121020"/>
    <dbReference type="eggNOG" id="KOG1552">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="446723at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN96429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="619" mass="69030" checksum="8008F6E63A8B85CD" modified="2014-11-26" version="1">MVVMPSRLDAFVKSIIFPRPKVATYDTSTRPNKLVHIPLVDPLTHLETGVFTYGYLLVNPKATHVLLYAHPNAVDIGIAYKELRYVGKEASVSVLLFEYSGYGLTHTPITEASIHQDTLSAYFFLCRYFGVSANQVILCGRSLGSSPAAFLAAFLPPPLSPCLLILQCPFTALSDCINEFSQNAVSIANFLGYNWFRTIDIITDVSCPVVLHHGTHDTTVSINHSYALQRARDTAAKPCVTYLYQEDGKGHNDLSSATLVRIIRERVVTEALPLLTLHHSRLFLANSPVYERLFCNDSGSGFATLKEATASWSAKLSLHFCAPPLDRLYVLLTASVCAFTMKCARVWQTYCALIKKNLCGGAVQERCPKDVFIRRCLACWGSPLAVHIAVQRVNSTREVRCFGFATCRDAMLDAPALYQTKSTEPLLSVLEIAVTPGLLSCMRRCLITAPNMLEDDEIPCFVQHDTVGALQLECERAVAFLTNEDKQRLCAFLKDMDAGFRKNLTNKAYERLRRSSSKSPTKGSESFEELKEWLRPWMRASGTDMQALAQEVPWDDYLLRGRSAAHQRVLSETMSWTECCQAMEESEVVLQIYTLFQEMSAQYMRPTFDSHAAAAAPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMJ2</accession>
    <name>A0A088RMJ2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_130030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697087.1">
        <property type="nucleotide sequence ID" value="XM_010698785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMJ2"/>
    <dbReference type="GeneID" id="22573113"/>
    <dbReference type="KEGG" id="lpan:LPMP_130030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130005400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_130030"/>
    <dbReference type="eggNOG" id="ENOG502S3V8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277159at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="23"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="200" mass="22687" checksum="85B50D884CAC4AF2" modified="2014-11-26" version="1">MMDPRNKQLPRVVEVSGDQRNRVQRLYEAIEHLSRRCRHLENTNERRSVVIDDLRARVARLEELFGKSQGEMAYAQQQLEFVVMGLESQHGIVSDHTEQLRLFADESTHRGCATVQGSAQRSLLLLIGNWLYTPVVHFAKGMYTILSPIITTAQSLSLLNSDVLHRNSSNRLRWGAARKGDLLAMLQRGALDPDSAANRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMM9</accession>
    <name>A0A088RMM9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">U-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_130550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697137.1">
        <property type="nucleotide sequence ID" value="XM_010698835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMM9"/>
    <dbReference type="GeneID" id="22573165"/>
    <dbReference type="KEGG" id="lpan:LPMP_130550"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130009700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_130550"/>
    <dbReference type="eggNOG" id="ENOG502RI69">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7537227at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16453">
        <property type="entry name" value="RING-Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U-box" evidence="2">
        <location>
            <begin position="631"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="585"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="704" mass="76497" checksum="C4CCF226E77AE458" modified="2014-11-26" version="1">MPVHPAVQLLCEQSVDAIGLTTVSAVASALGDVSTATDLIQRPEQEKALQDVLKKCVLILNNDGKNFALRLACLECLYALSQPAIPAFRKGLLCNTVNSMNSSVEELLTRTGPNGAENLSSAREMFMVLIFRFTNYHTKVTRLLLQHMCDADVGAMVQMLLRIMVHHCETCEWPLLQAALQSLYELTVPTTYYTTGEDRAAEPSRNSGATTTGSSLQSFTVESFQDKIVVLLTEMRDHRLLEQLLGSLRSSWHESTYHRSPPSLAQGYAESVALGALGRPDVAHTVTSASAEQQMELLNWLSAFTLLCRALENMVEFCRDVKLSREVRARLLGDPSCHDWLASAAVPAVIAAIQVWTSEVGASAPSAAVNDGSAGPFATANTRLILLTSAVTLLRLLRCALYKPVVGVTPALLSSMAYLAAQVQRGEPQLRLQYGGMQVMVLTAECLVNMNAAAVTSPVNLAEMYHRLLSTIAADKTRCTLSNTYSDAGSGLRAAAAPQADALMSVAEWFILCVREEESPFCETDSENTSRAVLHECFASVETKLQDTAERIADLVALESQLEMMQNLLLLMTLTELLSGLRDGGLEQLTRPGPPSRNTATGAQPKPPIKSGGLPKRSKSGKMKASHHPAAYVCDLTGKLMREPVVLRGGHRFEYDALQNVILQVGHVDPISGESIDEDVEVDMPLQQEIVAYRVKRASKRGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMW3</accession>
    <name>A0A088RMW3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C-CAP/cofactor C-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_190550</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TBCC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698050.1">
        <property type="nucleotide sequence ID" value="XM_010699748.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22574109"/>
    <dbReference type="KEGG" id="lpan:LPMP_190550"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190014300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_190550"/>
    <dbReference type="eggNOG" id="ENOG502R4AU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266740at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027684">
        <property type="entry name" value="TBCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012945">
        <property type="entry name" value="Tubulin-bd_cofactor_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15139">
        <property type="entry name" value="TUBULIN FOLDING COFACTOR C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15139:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07986">
        <property type="entry name" value="TBCC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="4">
        <location>
            <begin position="1653"/>
            <end position="1817"/>
        </location>
    </feature>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="4">
        <location>
            <begin position="1884"/>
            <end position="2034"/>
        </location>
    </feature>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="4">
        <location>
            <begin position="2128"/>
            <end position="2288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="142"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="286"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="414"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="507"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="593"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="732"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="808"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="891"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1419"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2481"/>
            <end position="2541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2577"/>
            <end position="2656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2826"/>
            <end position="2854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2922"/>
            <end position="2950"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="2983"/>
            <end position="3010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="146"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="184"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="343"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="463"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="525"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="547"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="602"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="621"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="754"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="779"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="832"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="845"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1435"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="2509"/>
            <end position="2526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2598"/>
            <end position="2609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="2635"/>
            <end position="2656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2922"/>
            <end position="2933"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN97397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="3041" mass="321807" checksum="B5A77047A8D02D46" modified="2014-11-26" version="1">MQFSDSTSSSSSAASTPRRRSGDHFVAVNASTPLASAACAFHGMHSSERHSRDNEDAQRLYGDNSSLRIQLTAGLHRADSPVSGVVAAPPGAKSADDDGQQLRIPSTQQAPSFFAKAPTASSANQRLWSDNSEAELDTKAFRMTQSPSSSTSPASSASSLTSGPQKAKASASAMKRLQLRRLSASKTPSMASSASSSTPLAPAARRRSSSSSSSSGSSASNVVLHRLHLPHATSAPLLMTAAAPPAASVPPPAHHVDPLRTDVMTTPPTAETSATLSLHPSRVEAPAMPASDSTLTDTGHHGTAGARFSTSSASPLTPNPAGSYRPPSNAPAAVCSAAPLIQPTSQLPTNTSFGSKPPSDSLLPHIKRAAAAHSNGVYSNFEDLSKEEVGENELNSSAASRAAHAALDAAELLHEHEGHSDPSPAQNAATPPPPPPSEQAHTSEGEVQPTKGGFIPRDKGCNGTVSGTLVSNRAGSVHTPPSERWPPVSDVERVGLDAVAAAEVSFDSGVTAATRRQPPPPPTPSTTTKKSPSSSSAMRHGVESDDTTSISSGDRSSDTELTVEQQNPPIMTQGTFTTHTAPVKATQAVVSYNPSALPPNRSSSSSSSSSHSSGNTRDCGGIRGGSAGGDGDSPAPVSDQMARAPVYKMHHNYDSSGDDTGALSPQLQTVMEYSGKLEEAAIAPNVGSAKVPPPTVMAGGTVNGANGQGVATAVSLPGFLQHLHHPVLQHAATSEMNGETKRAATVPTRPTIGSEASASRASAALMPPSPSQARTAETLDSNSSLSSSSGDSNAAVRRVLVMPLMRDFKSSSSTSSRDVGGNSNEPGKTIDSESASVASSEQAYIEERGNGSDRHTPPSHAMDAIFAKDMPAAHARVLPSVGALDSGCSWMREEEEEEGRPIHRVSAEEQDGNPLALQEASRWDDVLGEMELVDCSVVSRVYQQPMPRQRTGCRSNGEDEEDNIDSEDGDEYCIFKVVSLFPIAAADHCERWTLCTGVQRRLLALAEEMRATQRALDEAGLTAAQAVQAPSAFQHVGASGEVNTNRREAAGCSADDPEDAFAQRRRRTTCAGVSEVYVDSRCRLIAQLEVAPYTVPLRHLVATATSGTGLRENEVLALIRTVVCKAATMHNAGFVHGALHAGNVLLSSYDGDAVLAQPCGLMSQSSWLPCDLSVISVARAYAMAPFLPKVWGARQSHVGVTTSTRLGFPQRPNTAELITYHNLAALGWLNGNDAQNARQFNDGGDSAESSMPGTPYTPIAADDLYAVGMIAFLIYCGVPPFHMTSLWAVVERLTSLGDDYRAAMQYSSSSVAAARQEARRVVAEFCFGTCQQSNSVASLSSVEPMQQRAVARFRPEFEQALQSFIVDCVEASCWVAMLKPQSGVPYKAGATQHVYTDAQELLSGHPLFAYFALPEQADEDGAKTQENTHGGPSAVKEEPQQTTDEGMRDTVHRVAYPAFCTWARAREDCGSAPHMSRLHSNAVFTARCTALCEGVSAVTPYDDQATSVSPKALQKYELRSRLSILSPHVVGVLQGWQAPFLSGEAEISCGHDHQTDARTCEVTSAAVAGATRHRQWPGDARSATDAIECRHLPSLMRPSTVMAPAWLFANHDDDGGAEADISATALVQQEDALATQPFSGDGLRTDGSFVRHPHLRALTLARKQNGAFSLSRPFVLSCVLPAVDTLVLQHLADCTVTVLAPFRYIVLDALQRCEVRLGPCESCVLRDVHDCPLIAVAARQISGNNVTETHLSWSEQGSRRPLLKCSRGVTTSLYGLLYKGLVEDYSMVGLALEHAVCFADADELKSDSAEVDDAVAFRSPAMARRRTVELLASTAASENQSQAQVELCLAPEAPYDLTLLSSNTRYVHSGRQSSGMKSSWMPLPDVFHFFGELAEKDVVVCDVHGGTRDGEARPVVFLIGALGDVVVERCSYCTIVVAGTPSNLQASKCHDCQLIFMARESVIEDCARVECVALVTEYLLLRECDAVRVRPLFLHCPFSDEVLRRVVDGSVGGAEEEAVISAYEAGRLDELNAVLRGVGQGVYVEASQNVVVEDIGYYYHRSGRIDDGEHEEGEDGAEGDGFSVLSVAYVSIQSSTAVASSLGDASAFMAEAAQSLAEHLSVPCYLEPLQRYSSEKKDTPSHADRPVVSFHDLLNCSVLRLRGSLCPLELQAQSTSRDFTAALVDMCVERVHGGLIYVEDVVHTLCLRHCVGPLDVVVCASATVLMEACVGVQLRTACVNFNATDCVHCHLALHVNNAPQYQRCRSVQTSALNITAGDFDAMLTAAGVDLTTNLYNAPLLVAEEREPTVVAGSSGPSLESRGVHAFYGGCVDSFTAPYSTADMCAVLLATAHREQLHPQQGGAVDSRLGVPPDQVQRVMSVLRHPVTVVPPLPGLCVSPNEAPFLEELEAHVGLWAKRPLSVSREEAVAIALYALADLAEVYSSVTEWAETTDPVRFTEAGELVAECDASLDLDAPPQLLVTRAAPSPPTTTSASSTPGNLPRQASDAVQQRTPSPVQQQQQQLETEQCRAAGDSSVAGGQTPAMTMLLEVGVEEGAPGTEDSVEEVVIRRALLPSLPSPRSTRYADSTHLPKHNVDHTSSTEVPQASPVTLRRPSRPGNSPRHPRHGGLASFESTTLSRAAASSTGSSAAGLGDGASMIEDGASVNSSVTAPPLPPGPTYALDPTNFGASSTMDVFYRTQRDTALLATGTTGPLMEDDGGAYSVTAHHLDGEGLEFTSASPSPDHIRSPAMTDGITGCRLALVSPVGSSGHEGAWSGPQSFPVAANFNVRDAEARAQWPSSLQKSPRFVKSEVRSSHNGDELLGDITAPLSTNSTAGAKRPPTALVNEEDEPHYTSNAVYSSLRTSSSSLAEYRRRGVTSYAHNTEHVAGGGDDSAGESQLPETNFLHVSQDSSLRRLELNSPTPKVTSPTYMSARGEGEGSEASSFSRVQSTMLVPPASGPAAPPKANLLGMMSSPEVITMQEADADVRALLQQVEEARKRFARNQRSWQSPKDGGLEARVRAAVAKLTALKATCAEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNC3</accession>
    <name>A0A088RNC3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kinesin, putative</fullName>
            <ecNumber evidence="5">5.6.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_181550</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.3" evidence="5"/>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697988.1">
        <property type="nucleotide sequence ID" value="XM_010699686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNC3"/>
    <dbReference type="GeneID" id="22574045"/>
    <dbReference type="KEGG" id="lpan:LPMP_181550"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180018700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_181550"/>
    <dbReference type="eggNOG" id="KOG0241">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="123929at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000169">
        <property type="entry name" value="Kinesin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115:SF929">
        <property type="entry name" value="KINESIN-LIKE PROTEIN AT 31E, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="KINESIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="4">
        <location>
            <begin position="5"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="587"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="662"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="337"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="591"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="677"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="711"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="91"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN97335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="791" mass="86005" checksum="0947BB231E97E774" modified="2014-11-26" version="1">MSQRRVEVAVRVRPNTELRRNSCVSLSHATHHISLQDNSGVNALAGRRSYKEDFLFDEHVSNRAVFEKLVLRRMLAATPEHPDTLCFLAYGHTSSGKTYTIGGSEKEPGILALCVEELLRGEGVVEVAMLEVYLESVNDLLAHGEPRHIRRRQGPLGPVIVVEGLTTCSLTSVQQWNAVAAYSMSSRRTAPTERNPRSSRSHAIFTIKSRGVRLCFVDLAGSERQTVFSPQLNKESISINKSLSRLSTVLEALSNQRVTQDGARPYVNFRDTTLTVLLQRYLTGSSMTTFLACVHPSADYYQETLSTLRYTQRLKRIRTRVTKVDEVEWSEMKTSEHQVLLDELTRLREQMKASENASKLVEAAHQRRIAELESTLAKQGRSPCGAVGASLPLLSPPRELNASRARDTRRVAGWLLSRVLGELPELNVGYDAYFDAYFPPSVQVIGYVSTMASLVPRIPGDDPLAFLDVGDLAMGLSMLDAGVPPFVRLHTSRCGDPSGWEGYEWDSSHDVVYVLAFFEYHPTAMSAAGMEEALQCCGGYVTSAPLLPIATVLCVAVSATRRVKEEVLQRLVDLQCEQHEAVMEQANAGARTPSLSSSLSSSRQSTLPSGTELLDASLVHSVGGAEGDNDASAISSAANGNALLGKEVHNQAADTPCIVAPLKEEDSSTNNSNSHSCDSRKEARAEIGSAEVRHSVGECTAPSRPSVSPPREGKAEETKAAEGSPTAAVSFPQSAPPTRRLFSPQRPSGTALALLPPADEVSPGCTSKRRHRTAREGKAVRMQTCQGCSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RND5</accession>
    <name>A0A088RND5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Elongation factor 1-beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_200850</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the EF-1-beta/EF-1-delta family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698284.1">
        <property type="nucleotide sequence ID" value="XM_010699982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RND5"/>
    <dbReference type="GeneID" id="22574292"/>
    <dbReference type="KEGG" id="lpan:LPMP_200850"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200012700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_200850"/>
    <dbReference type="OrthoDB" id="331763at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005853">
        <property type="term" value="C:eukaryotic translation elongation factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00292">
        <property type="entry name" value="EF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.60:FF:000001">
        <property type="entry name" value="Elongation factor 1-beta 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036219">
        <property type="entry name" value="eEF-1beta-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049720">
        <property type="entry name" value="EF1B_bsu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014038">
        <property type="entry name" value="EF1B_bsu/dsu_GNE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001326">
        <property type="entry name" value="Transl_elong_EF1B_B/D_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595">
        <property type="entry name" value="EF-HAND AND COILED-COIL DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595:SF82">
        <property type="entry name" value="ELONGATION FACTOR 1-BETA, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00736">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00888">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54984">
        <property type="entry name" value="eEF-1beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00824">
        <property type="entry name" value="EF1BD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00825">
        <property type="entry name" value="EF1BD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange" evidence="6">
        <location>
            <begin position="107"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN97577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="193" mass="21084" checksum="221A294A793854FC" modified="2014-11-26" version="1">MLNDLLGANHASLYRWVKNMATYTEGERKAWGAPVRTAAPELRMPAPAAAAPAAAKKPAPAPKAVAPAEDDDIDLFGETTEEEQAALEAKRAKDAEKKKAKKDVIAKSSILFDIKAWDDTVDLEALAQKLHAIQRDGLVWGDHKLAPVAFGVKKLQQLVVIEDDKVSGDDLEEMIMGFEDEVQSIDIVAWNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNH0</accession>
    <name>A0A088RNH0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_190480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698043.1">
        <property type="nucleotide sequence ID" value="XM_010699741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNH0"/>
    <dbReference type="GeneID" id="22574102"/>
    <dbReference type="KEGG" id="lpan:LPMP_190480"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190013100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_190480"/>
    <dbReference type="eggNOG" id="ENOG502S1FU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272083at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="213"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="299" mass="33032" checksum="DBC0C951813194D5" modified="2014-11-26" version="1">MEKTINIFGRGTPAGEAIYRCYVAPSKPSTLDPELAALLARRRQEREVAEAAQVHPKPIPKSKAPVHRPRVGLRRRPTEEEYARWRLSNISHRRSKVAIEAEEEARRGIPQSVNDRFTRPAITDAEKDRLADVMAYGAELPKPKEFTGAQRVRLHRLNPRAELEDRFARLRQIAQEVQSELAQLRQGSLGVGASSPSGGNAVDDVLDAQARLSERRSRGDGSDSVTASPHPLVTATSPGAAATSDVLNIGGTRVGRHGGNRMSKIERCQRERELQSHLDTVIAEMEAVDRELSRLPISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNM1</accession>
    <name>A0A088RNM1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Leucine-rich repeat protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_200560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698255.1">
        <property type="nucleotide sequence ID" value="XM_010699953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNM1"/>
    <dbReference type="GeneID" id="22574263"/>
    <dbReference type="KEGG" id="lpan:LPMP_200560"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200009900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_200560"/>
    <dbReference type="eggNOG" id="KOG1947">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271218at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF105">
        <property type="entry name" value="F-BOX_LRR-REPEAT PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="588"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="626" mass="66703" checksum="4EBCEFB04BCD41FB" modified="2014-11-26" version="1">MADPAHAREGFWEEQQHQQQLLQMTRGVFEAMHNNSMQMLQMRVDTLERQVAMLSAQVMASTLPTPFQAYPGVTYGMSPATSNLTPTPTMPAQMPASMYYYQSPDMPAAAPANSSAVDDSKASKQLEDELQRMGVLTYSGAAAGTNTSPEAAAAAATMTLMHSNLMVSPTSGISAFPGVMAGVSNPNPAGPSIPFMTGNHEVTFAPSIMPAPPASSPTKISNALLQKAFGFSDTSMNGAGGEGMSANMSSLQRSCAVTLDPLQSTTETLEQTCQQTKMRVLCLKGCKGITSLNAISRLQNLWLLNLQGCSPCVDDSAVRMIATHNTRLSRLNLCGCDRVTDAQPLAQLSLMFDLNLSGTMIGTASLEAISKGCGQLSRLAINSCQQLSGVSSLTNLSELKLLYCRYSENIDPATIGSVLAGIGQNLLTLNVDGIRFRQLDLSHLPHVTALKNLNCKDNTQLRDLDWLLSIPNAAKTFESLEMLDVEGCESLVSFGTHITSLKRLKTMRLTNTGIADGELARLTACSALATLHLDGCAAITNVECLAKAPSLTKVVLSMHMQHENTKANGLDALRKRAGLEIIFAAPNNHHGQGSAAHHMTTTPTSRFPPSIPTASPNTATEAHAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNP5</accession>
    <name>A0A088RNP5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="9">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_200810</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPP phosphatase family. PP-1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="9"/>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698280.1">
        <property type="nucleotide sequence ID" value="XM_010699978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNP5"/>
    <dbReference type="GeneID" id="22574288"/>
    <dbReference type="KEGG" id="lpan:LPMP_200810"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200012200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_200810"/>
    <dbReference type="eggNOG" id="KOG0374">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000047">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF396">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="119"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN97573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="298" mass="34378" checksum="55D737684F8639F6" modified="2014-11-26" version="1">MSSLSTVHQLIERLIMVQRNRGPPQVLVREEEIRAVLTEVREIFMSQPMLLEIRPPVRVCGDTHGQYYDLLRIFEKCGFPPYSNYLFLGDYVDRGKHSVETIILQFCYKIVYRENFFLLRGNHECASINKMYGFFDDVKRRYNIKLFKAFTDVFNTMPVCCVISEKIICMHGGLSPDLTSVASVMDIERPCDVPDRGILCDLLWADPEDDVQGFLESDRGVSYLFGEDIVNDFLDMVDMDLIVRAHQVMERGYGFFASRQLVTVFSAPNYCGEFDNDAAVMNIDDKLQCSFLIIPAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNP9</accession>
    <name>A0A088RNP9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Adenylate kinase, putative</fullName>
            <ecNumber evidence="4">2.7.4.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_160030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.4.3" evidence="4"/>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN96879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697532.1">
        <property type="nucleotide sequence ID" value="XM_010699230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNP9"/>
    <dbReference type="GeneID" id="22573580"/>
    <dbReference type="KEGG" id="lpan:LPMP_160030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160005200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_160030"/>
    <dbReference type="eggNOG" id="ENOG502SEKC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22981">
        <property type="entry name" value="DD_TbAK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47391">
        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN96879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="214" mass="22991" checksum="9AAC2BAAA6B91576" modified="2014-11-26" version="1">MSIGSLSDITLQYLESKGIQFILDEAMHNVVLQMPEDPLAFLEKEFRRPTPVQVILTGPCGSGKTTLAAKLAAHYGIAHVSATVADVGDVAIPADMLGELKGLQQEGRGWVLDGFPQTRADAIQLQTSGISPQLLFELQVPPGVALERATAHAGASSKHTEAAAPIVKSYHLYDVRRTEIVTSYQPFYRAIDATVTADEVAANVMKAIDTLHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RP20</accession>
    <name>A0A088RP20_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ADP-ribosylation factor-like protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">LPMP_161340</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Cilium membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN97009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697662.1">
        <property type="nucleotide sequence ID" value="XM_010699360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RP20"/>
    <dbReference type="GeneID" id="22573713"/>
    <dbReference type="KEGG" id="lpan:LPMP_161340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160018700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_161340"/>
    <dbReference type="eggNOG" id="KOG0070">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04157">
        <property type="entry name" value="Arl6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000457">
        <property type="entry name" value="ADP-ribosylation factor-like protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041839">
        <property type="entry name" value="Arl6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11 16 18" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="9 16 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="14"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="120"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AIN97009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="182" mass="20250" checksum="62EBFF347C78CE2D" modified="2014-11-26" version="1">MGQAKTKLNIIICGLDNSGKTTIINFMKPEDQRSENIAATVGYNVDSFKKGRVHVTAFDMGGAQKFRGLWESYYSNVDGVVFVIDSSDALRMCIVKDELEQMLHHADLKTAKVPFIFFANKMDLAGAKTPVELTQILQLNSLMGDHPMNIFASNALQGEGIEEGMDWLQSMMLRQAVLSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RP49</accession>
    <name>A0A088RP49_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_203780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698579.1">
        <property type="nucleotide sequence ID" value="XM_010700277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RP49"/>
    <dbReference type="GeneID" id="22574589"/>
    <dbReference type="KEGG" id="lpan:LPMP_203780"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200043900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_203780"/>
    <dbReference type="eggNOG" id="ENOG502S2M0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="274929at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="103" mass="12158" checksum="958EAFA0D6026638" modified="2014-11-26" version="1">MLRRLASKTTMTAAAPLLASTRNYNFFVFQNPVRRPQLSPEERAKVQINYAEWPEEFRNFDPEDPYKNSPEIIEGLSSWNLFLWGVECAFIYQFYEVVFPKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQ20</accession>
    <name>A0A088RQ20_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Histone deacetylase</fullName>
            <ecNumber evidence="1 4">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_210710</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="1 4"/>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698859.1">
        <property type="nucleotide sequence ID" value="XM_010700557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQ20"/>
    <dbReference type="GeneID" id="22574893"/>
    <dbReference type="KEGG" id="lpan:LPMP_210710"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210011800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_210710"/>
    <dbReference type="eggNOG" id="KOG1342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09991">
        <property type="entry name" value="HDAC_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000017">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF10">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="9">
        <location>
            <begin position="43"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN98152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="432" mass="47379" checksum="9690B1FC1921BB07" modified="2014-11-26" version="1">MHALHKDGAEASLLNSESRGRVALIDTSAYASDMNISAFVPQHAMKPYRVLAAMEIVRKLKIDAHCRTVVPPLVKVEELMAYHTDTYLANLGVHSCRSWLWNAETSKVFFSGDCPPVEGLMEHSIATASGTLMGAVLLNSGQVDVAVHWGGGMHHSKCGECSGFCYVNDIVLGILELLKCHDRVLYIDIDMHHGDGVDEAFCRSDRIFTLSLHKFGESFFPGTGHPRDVGYGRGRYYSMNLAVWDGITDFFYLGLFKHALHSIVRRYSPDVIVLQCGADSLAGDRLGLLNLSSFGHGQCVQAVRDLGIPMLALGGGGYTIRNVAKLWAYETSILTGHPLPLNTVLPVAEMPLSGWLFQDSPLLIVAQDRSNHVLPGLHCQRAYQMMMEQIDRHVPHIEPHPRLQKAAAATAVAGGEEKQEEDGTAAITGVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQ22</accession>
    <name>A0A088RQ22_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Fibrillarin, putative</fullName>
            <ecNumber evidence="11">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_190070</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Fibrillarin family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="11"/>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698002.1">
        <property type="nucleotide sequence ID" value="XM_010699700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQ22"/>
    <dbReference type="GeneID" id="22574061"/>
    <dbReference type="KEGG" id="lpan:LPMP_190070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190009000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_190070"/>
    <dbReference type="eggNOG" id="KOG1596">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990259">
        <property type="term" value="F:histone H2AQ104 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000001">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000677">
        <property type="entry name" value="Fibrillarin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00351">
        <property type="entry name" value="RNA_methyltransf_FlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000692">
        <property type="entry name" value="Fibrillarin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020813">
        <property type="entry name" value="Fibrillarin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003276">
        <property type="entry name" value="PRK04266.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335:SF13">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335">
        <property type="entry name" value="RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01269">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006540">
        <property type="entry name" value="Nop17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00052">
        <property type="entry name" value="FIBRILLARIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01206">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00566">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN97349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="295" mass="30928" checksum="6AE6A632B9BBA20F" modified="2014-11-26" version="1">MRGGRGGFGGRGGGGRGGGGRGGGRGGGGRGGGRGGGRGGGRGGGRGGRGGTGSPKGNIFHPHARFNGCYLLAGKDTLSTQSLVPGVSVYSEKRVNGTVAGESESHEFRVWNPYRSKLASAIYAGVASIYMEPGSAVLYLGAASGTTVSHVSDLVGPEGIVYAVEFSHRSGRDLEEMTKRRSNIVPILEDARYPQKYRMLIPRLVDCIFMDVAQPDQARILALNAQHFLKANGGFVISIKANCIDSTADPAAVFASEVQKLKDSGLRPKEQVSLEPFERDHCVVTGYYKNVPQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQ53</accession>
    <name>A0A088RQ53_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_210120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698800.1">
        <property type="nucleotide sequence ID" value="XM_010700498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQ53"/>
    <dbReference type="GeneID" id="22574834"/>
    <dbReference type="KEGG" id="lpan:LPMP_210120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210005900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_210120"/>
    <dbReference type="eggNOG" id="ENOG502S4W4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="242141at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="184" mass="21013" checksum="995241F368D30FFA" modified="2014-11-26" version="1">MDIEFGNWKAARPRVHLMIIFLFITTDLVNLIRYILYLLPSRNLYRAYGINAYIIFTCVGIVFFAGVSAPLIYWPYAHGKEMSPGSRRNALCLGIIISFLVHGLPMAWLELWLVTTFGWRDILQAVSLFLTLLCFIIGFLVTWMAYSWKLSKVLQIRYGNAAPSQSAVPAAQLARRSLSQAYRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQ92</accession>
    <name>A0A088RQ92_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exocyst complex component Sec8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_211740</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SEC8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698959.1">
        <property type="nucleotide sequence ID" value="XM_010700657.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22574996"/>
    <dbReference type="KEGG" id="lpan:LPMP_211740"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210021400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_211740"/>
    <dbReference type="eggNOG" id="ENOG502R8P6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272977at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039682">
        <property type="entry name" value="Sec8/EXOC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007191">
        <property type="entry name" value="Sec8_exocyst_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04048">
        <property type="entry name" value="Sec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec8 N-terminal" evidence="5">
        <location>
            <begin position="76"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="285"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="533"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="917"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1414"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1472"/>
            <end position="1572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1604"/>
            <end position="1741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="314"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1433"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1507"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1524"/>
            <end position="1533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1540"/>
            <end position="1550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1555"/>
            <end position="1566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1604"/>
            <end position="1628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1640"/>
            <end position="1654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1660"/>
            <end position="1700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1732"/>
            <end position="1741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN98252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1741" mass="189716" checksum="E80DE60C5CC5431B" modified="2014-11-26" version="1">MPNSTASPRYQDELDEEDVDQLSAVDRDFVMNTKDLFEDVDAELLSEDFVPHEHVVGIIVSETTGGEASLHEIDDNLMDYKDLEAEINADLADYIDAHHQEFNNAIYDFSEMVLAVSGSDDTLAQFKKELADAVGSLESHAGELKVLRLRAAKSLFMVDAFKHIQEVVLAETEVKGLIQNRHYLAAVQKLQTQARLLASDEMRGVRAVQTLRDTHNATVSTLHHLIIDDLLACVFRHERLVEADAQLLQALLDSSERDTKDTHVAAPSVQDAIYTYWKGANISTSGNDGTVEEEDSAGETHREGDGGGGGASTHGGTTTDSATAAGAGRPVRKEHTLAAIIETLTDDPTEDHVFSNYLKFVPLSIKSLMMLGKIDRCHETFFSRATRNIERFIAHFISLYDAWRRRTRNGVSLSNDEAEAAIRGTYVRALDLANDLISFDEAVATIQGRDLHSMLGALFTELEKVLRNAAYLQKVVLVAHFPFVSSFVVQPVPFSPEATSSQWNVVDVPLRSATWLRDTLTTALDYAQNSLPKVPATRDESSSNSLHASGGDQDADDVMTNFLRFFNVDAVLAPLKTEAVEKDAAPAAAAAAAPLKLKRSGSVESVAASDSSPFLSFDQCKPFLTLRGICDLVDSACAQTLATYPSTPKAVLRKLQLTLTAELRDAVRVKLVAEVQGMLQEWDLQVLWSQLNYHIELFFHAICDAKEAQDETDDAVTLLPFLRQKNLISRVQRTANILQDSDKQGDDASTLERLLSTFESGGVLRMMEETGTVSFSLVGAVKKAQADLRKVSEGQTRQLEAMQSDTAKFMALADSGQGGGGVSGARAPLVLLHANMLRRWFVFTAMNALTCYVCAARFYSRCCDRVPEFRLLSEESCIVGFFKRFLRATYIPTLHAFHSQQLQLLLMSIGDNAGNSAAGAAPPASTPLAGTDPTAQRSGKAPTAMNTLNGAWPAVVVDEVQYPILACVQYVGQVLAKVNNVRDILPKSLTEEVEQNTSEALIMELVVFLKRQVQWLGRGTLAHRLLNRPFADAFAGMPNRKWAALVDEENIMEAHKYIDQDLYRYYQFNSNERTSGHEYNSTVSLLEAMRMLETSFAVSPGGGGGADDAEAELDRQIGRMEPRDICVHDDSTLVAFALLCTSAEWLCDLLLRYLWPSRRTAHNYTDCCVPGYCFTQEMRISAGTSSEFIDSDYAAQQKVRLSSHLVRLCSIAQVALFHLSVEARFLAFLFLPQLRDVSYDVVAVSSAADMFVQAYARRVHNFYAILRQHLHAKKIKYTCLTAGKPASELILMELAHLRNKAISQAGLMRLRTDLLVMQTTLQLILPTDTDVREAVPRLFLRPALFLRYIFNRDVVSEIVSSLDYLNFSTKEVEVLIRLVFRQVSGANDDTLAVQHIQWFYQKLKIIQNLRYSSTDAGSRGSIGKASLQPAAHDTSNGGVSGDTPSSLVPLSRNAAAVVAAALDGGDDYHNSAFSYDEGGSDASDSQPPPLPLLSATRGRQSALGGLAASPSISVPSTPVPAPLPASNAAAPVSTQPATTSEEDEEDEETPEVSTMQRSVRQPQQSPIIPGAAAARSFTSATAAAAGGAVAAALGSRSMLHAAPTSLQATPSPSSLSSAAAVKPALARPAVPPLATEPLRGASATAPTPSAKTGAVKVEEPSEDEDDEEYEYEEEETSEYEEDEGDEEDEEDEEDEEDEEVPTSATSVKRPLHPPPHPAVAPNSRASMASGGPSASTAFARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQF9</accession>
    <name>A0A088RQF9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_191380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698132.1">
        <property type="nucleotide sequence ID" value="XM_010699830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQF9"/>
    <dbReference type="GeneID" id="22574192"/>
    <dbReference type="KEGG" id="lpan:LPMP_191380"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190020900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_191380"/>
    <dbReference type="eggNOG" id="ENOG502SGKR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271266at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38827:SF3">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38827">
        <property type="entry name" value="T. BRUCEI SPP.-SPECIFIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="114" mass="12305" checksum="7A7B47875F82761F" modified="2014-11-26" version="1">MFGRRVASSCRIPASMYARLHISSPQQANRMLPPLVPITTSIYRSVSGGTGALAFLGTGSEVVPANLTSPENLLSLLCVTPQALLGIINANTLLLRMVSDTMWTYSFTLLHVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQI0</accession>
    <name>A0A088RQI0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_220840</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699084.1">
        <property type="nucleotide sequence ID" value="XM_010700782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQI0"/>
    <dbReference type="GeneID" id="22575130"/>
    <dbReference type="KEGG" id="lpan:LPMP_220840"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000029600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_220840"/>
    <dbReference type="eggNOG" id="KOG0743">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="328"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="472"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="634"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="472"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="486"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN98377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="709" mass="77484" checksum="68DEDC5EF592BBBC" modified="2014-11-26" version="1">MTSMTRISSSVISDNKSHENDFSLFNGETPAQLRQLGPLIHTTVSAFASALEYWSPFAPEWLLLLAPFMVGLVQVVWPTVSAGVSVWRSGVGRRYAFRVLVHEAPLNLYDDVNNLNELMVNAVLMYVCGTLWRQNPVPESQLRGLQMRAVLMDPYRCYKSNDYDSPFRCAYVESDADEGQKLKEETVARLRVAKVPLDAYLPVQVDGIELCYEEESFHRKGSRDPWTRHKLTLRCANSRDAGAKLDAFVQRALEVFAEGAPGKEEDDGARWFFAYGGESDDKVYFNQYVLRSNKGFDTLFFPQRDATLTLVDQFAQRRGRFAVEGFPQRLGFLVYGPPGTGRHAFVKALAAYTGRHVVSVPLSKLRTNQQLYDIFFVREFQSEEGGSVQKLRMEDVIFLFDDVDAANPVVCARDGSRVVQRRAAARLTARAGLRDAPLTTCVIEMDTSSSRPVVRTEDSALPLALLMEIMGGGASKDGGGGSKSEGGSRRRTEKRAAVTAGDAGAGVVGGNLFEINGMLFGENKDRLDLAGLLNVLDGVLDAPGRMVVMITEHPEWLDPALVRPGRFSVRLRLDYMEMEALVQMLGLYYGDVEHSPRGIGAGAGAVGADAGSGVGAARAAQCPAVGAAGRAVHRELSEAQVARVRGAVAALEEEAEAAAAREVDTDGSGERKYCFQVTPCEVEMLCMGQDDLEGFLTQLAGVVRGTGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQK9</accession>
    <name>A0A088RQK9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_200270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698226.1">
        <property type="nucleotide sequence ID" value="XM_010699924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQK9"/>
    <dbReference type="GeneID" id="22574234"/>
    <dbReference type="KEGG" id="lpan:LPMP_200270"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_200270"/>
    <dbReference type="eggNOG" id="ENOG502SPM1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="258373at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="158" mass="17816" checksum="BD560973FC15D7BE" modified="2014-11-26" version="1">MLKKCLHFRVVNLGGCHEIAEVLVFAALKEVRELFVHEAAAGITALTICERLERLSLGCRVHVSDGNHLRILANLVKLHLWSTKVRNAEIVGFAFFCVLVELIVDDGVRVTDVFPLDFLQPISWLSLIETEVDARGVKVLLYYQRLEILALGGTRVFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQM6</accession>
    <name>A0A088RQM6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_200420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698241.1">
        <property type="nucleotide sequence ID" value="XM_010699939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQM6"/>
    <dbReference type="GeneID" id="22574249"/>
    <dbReference type="KEGG" id="lpan:LPMP_200420"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200008000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_200420"/>
    <dbReference type="eggNOG" id="ENOG502S2QI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="245072at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="424" mass="47996" checksum="7DDF30EF2F2DE18C" modified="2014-11-26" version="1">MLTQPSDELERLRKELALEENDLAALEDNVESQSAQLGYLHTEYTINKTRIYHHYEPTLAPLRVVTYAAAQRQSLIELQIEWLERKVVEQERRSQGGQYIEIRDMKPAAEEYLRKAHQSLLRCYEHISECPEEPLHIISQYACPPEEAIATMELVMKVRGEASESCTWKASQVLLSYTYFHEFFAMRSESLLKRCDLLPNELMSELERFCADPHHSVCSLYRISTPIGCMGEWLHAIRNYYRVKLVTAPVLLSRHADTRRITEQAQAWLSMITLSEEEGDQRQRQREQQTTVAKDASTDNAELGALVSAGEAGRESLLLPTKSASVTADTVQKLRHQLHKLRESVRAAEAERTAIEGLLQEKLAEVRGNYDETMVPLEDQLEEMTECFGQRLTRKGDVAAAPPLPAATAANTTDNAAVAVAATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRC0</accession>
    <name>A0A088RRC0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_221560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699157.1">
        <property type="nucleotide sequence ID" value="XM_010700855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRC0"/>
    <dbReference type="GeneID" id="22575202"/>
    <dbReference type="KEGG" id="lpan:LPMP_221560"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220019200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_221560"/>
    <dbReference type="eggNOG" id="ENOG502S403">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273130at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="617" mass="67570" checksum="05F9665595A6883C" modified="2014-11-26" version="1">MLRGFSWHGDSFLDALLDELTVNPYSDLPAAVARVERAQTAESNVELMKQRRVEQQEEHAIRLRDEWASATRDQRVAPRDGLEGSTSLETLVLSSSTYLANLARAADRESVVSLPGASSALELPPLRASTRLAAEALLPLTAALTGSHIGDDHVASALYSAYVHLLPYILAVAAPPSRCSTASFSPATSSTTVAVVACGGSESMLPWYAVHTSDSAVRDLLSPYMSSVVGQLEKELRFHFNVGCDTAAVHEPQHFFSFLMECFQRQQRIAAEQWAPSALQGSEVDAALRVLESLSQVVLSATAVVVFQESYGWRPSLGLSRHKDYVVVTVNAVLDFVASAEGRLCRDAVQLLVEYLLTEEVLQLYTQCGADMAVAALRDGTARLWRRSFLTEGGCHASFPLYTCGLHLVRSLEAFQRRLLNSLLLLEGPWAELVWRRSVEPALLAFLGIVEKEALPMVEDAAAASWESVLSLQWCVASVQVVAAAAEDWLGMLRESSAATVRRATSSSSLSKSETLDRLILFRDQLSRCSAEKAQLLTRQLCTHQPEDAVQAARVLHGAEELLKRMGTLPDGTSTRYIVQDVMRGILQKDFSPEHKADLLSYAKRCGLQRVAQLLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRN4</accession>
    <name>A0A088RRN4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protoheme IX farnesyltransferase, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_231800</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699335.1">
        <property type="nucleotide sequence ID" value="XM_010701033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRN4"/>
    <dbReference type="GeneID" id="22575385"/>
    <dbReference type="KEGG" id="lpan:LPMP_231800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230026100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_231800"/>
    <dbReference type="eggNOG" id="KOG1380">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5211at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000006">
        <property type="entry name" value="Protoheme IX farnesyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01473">
        <property type="entry name" value="cyoE_ctaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448:SF2">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN98628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="385" mass="41637" checksum="085F49CAB4601363" modified="2014-11-26" version="1">MLRITAARFAQLFRLTQRTLQSGAFTACPYRHSKEGSATVMAQGAVEQCPVVGTAPHMSCPVEVGLCDHRPPTMSRMVSQMGKSQLSAYVAATALVGYVIAGGASPFIAAAVTAGTMLQSCSANTANQIVEAPYDKLMKRTCRRPLPMKFLSPQVAMAISGVELAVGTGLLYCVSPLAAALGVFNWLLYVCIYTPLKRVSALNTWFGSIVGGVPPLMGGIAVAGSITPPVWLLATFLFVWQIPHFNGLAFHCRRDYEAAGYKMLAFYNPWRASFYAVALSVLMAFLTLVCPMLAGMEVEGVWYYSVMATANVLMIYKSLLFHNEPVRHCRGCFVFSYVYLSVVLAAIMLNHIQPMHLARRVIGYAAADTTEVSATSSALIPTAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRS5</accession>
    <name>A0A088RRS5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="8">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_204510</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ATP = O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23052"/>
            <dbReference type="Rhea" id="RHEA-COMP:13689"/>
            <dbReference type="Rhea" id="RHEA-COMP:13690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="8"/>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698651.1">
        <property type="nucleotide sequence ID" value="XM_010700349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRS5"/>
    <dbReference type="GeneID" id="22574662"/>
    <dbReference type="KEGG" id="lpan:LPMP_204510"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200051800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_204510"/>
    <dbReference type="eggNOG" id="KOG0787">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="241648at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16929">
        <property type="entry name" value="HATPase_PDK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF3">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase N-terminal" evidence="11">
        <location>
            <begin position="81"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="10">
        <location>
            <begin position="302"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN97944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="443" mass="50048" checksum="71CD1DD7E385FA38" modified="2014-11-26" version="1">MRRLVSTTKLLGSTAGIRLSSTKNSDRERLERLVEEVKGIKSKLKVLEESKAANGLVDLYASRKMKKLDIKRILGIFNDRAYHAPIFCHKTLPIVLAQFITGLDRLPSGLNAMPSILSVRATLLRSFQKLINCKIPITDGQVQHFRRVLEDIDEEHAERELLQTMAFGILELKEYVSCHRRALVELKKTSERWASIPMREEDVLTHAEIQDIQAPLDSVNRCMITYNFISRMFLNHDPEMMMDSNPSRVGMVDLEMNLEHVVRNAVDEAKQICTDYYGDCPDTEFELTSDSKAFRFPYMSTTIRYIILELMKNAFRATVESHMKRNDLGIVTCADMPPVRVLINLQEETEHACICISDEGMGMTDEALAMAMAYSYTSVSKPALQLCESGEKSASTAPSPLAGYGYGLPMSRVYAQSLGGDLFLQTMEGYGTRAYYYIKIADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRT5</accession>
    <name>A0A088RRT5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_242050</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699544.1">
        <property type="nucleotide sequence ID" value="XM_010701242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRT5"/>
    <dbReference type="GeneID" id="22575614"/>
    <dbReference type="KEGG" id="lpan:LPMP_242050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240027800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_242050"/>
    <dbReference type="eggNOG" id="KOG3283">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276437at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11380">
        <property type="entry name" value="Ribosomal_S8e_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.70:FF:000008">
        <property type="entry name" value="40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.168.20">
        <property type="entry name" value="Ribosomal protein S8e, subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001047">
        <property type="entry name" value="Ribosomal_eS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018283">
        <property type="entry name" value="Ribosomal_eS8_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042563">
        <property type="entry name" value="Ribosomal_protein_eS8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00307">
        <property type="entry name" value="eS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10394">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01193">
        <property type="entry name" value="RIBOSOMAL_S8E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN98837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="219" mass="24565" checksum="34F0E14A36261EAF" modified="2014-11-26" version="1">MGIVRSRLHKRKITGGKTKIHRKRMKAELGRLPANTRLGARRVSPVRARGGNFKIRALRLDTGNFAWGSEAIAQRVRILDVVYNATSNELVRTKTLVKNCIVAVDAAPFKRWYAKHYGIDLDAGKKSAKTAAAAEKKGKKSAHAAAEKYDVNKASPKLQREWTRRRSSHKVEKAIADQLREGRVLARMTSRPGQSGRADGILLEGAELQFYLKRLEKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSR5</accession>
    <name>A0A088RSR5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CYPA</name>
        <name evidence="6" type="ORF">LPMP_250930</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699662.1">
        <property type="nucleotide sequence ID" value="XM_010701360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSR5"/>
    <dbReference type="SMR" id="A0A088RSR5"/>
    <dbReference type="GeneID" id="22575741"/>
    <dbReference type="KEGG" id="lpan:LPMP_250930"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250015300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_250930"/>
    <dbReference type="eggNOG" id="KOG0865">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097014">
        <property type="term" value="C:ciliary plasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000013">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF580">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="17"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN98955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="177" mass="18765" checksum="9081486530FCFDF2" modified="2014-11-26" version="1">MSYKPHYPTVSSNPKVWMDIEIDGQSAGRVTMELFADAVPKTAENFRALCTGEKGFGYSGCPFHRVIPEFMCQGGDFTVGNGTGGKSIYGNKFNDESFAGKAGKHFGPGTLSMANAGPNTNGSQFFLCTAPTSWLDGKHVVFGQVLDGYEVVKAMEGVGSRSGSTSKPVRVSACGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RT29</accession>
    <name>A0A088RT29_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_221110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699111.1">
        <property type="nucleotide sequence ID" value="XM_010700809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RT29"/>
    <dbReference type="GeneID" id="22575157"/>
    <dbReference type="KEGG" id="lpan:LPMP_221110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220014500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_221110"/>
    <dbReference type="eggNOG" id="ENOG502R9XB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="278250at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="789" mass="87689" checksum="D868CF7DBA55E4DD" modified="2014-11-26" version="1">MAMKEFVKKMSPLTRDDMFRRHVDALEWITESKLLELVNERGEAILLESLRAYPTAVASVSQGEAARPALYNGLVHVRATVPAAWLLQAGGGMESVSETTRPCSQLTHSAPSTSRMAGAASTVTELPFTPDESDDGSDGAAALSSAEREAIIREAFLRALRNWDTAMQLRRERAEESVALAARDSAPDLPRYTHLTNMYNAILREAAATTNASTTGEDADIEVAPTPLTPAARYILKRLRMDTLESIVENSSVVVTVGHTASAGAQGPSGYPAMTSRPIWVVRGTARHPATFVALRHSTDVSPPRFRYVQPRVTVATRANGYGGWGSDSVVPTKADVYEILKYVPVNWGSIGNLNLPPEVKKKHIRTSSLVVWFRRQPFYFELRDMNGTLEVRRSIVLHPEAHGMTKEEAWEVLELQLATGEANSLVPLGVDGAPLRPTESTFDRSITKFVYRVCPTYFAPLSLTMQRYVKKNLTEPMLMTFVRRFPQDFEVFTSRYSDIPLVRRRAGADSARWLTNFVADLERYPEDVRGILVLCNSMCAAWDRPEYIYVRLSSTEQEVVGGYAGMQTILGRHPAIFRVGQHFVCRTDPSNPLAQREVEPAADGVAAVTPIHEENPYHSPKELALVFHYIMPENEPCTAAYLVDCSSPAMRALLPPRLVTIVQLFPKMFACTETSPGVYSIRKVKQPARKAAHGVARDDCSSEEEDAIQMLEDELADEDRMTREEVVHAVRMLIPESGVDAPQLLLWASMGVQRAAGEYFGGVLRLVESLPGQFRVVTKEHAKRIYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTC1</accession>
    <name>A0A088RTC1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AMP-activated protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_230530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699211.1">
        <property type="nucleotide sequence ID" value="XM_010700909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTC1"/>
    <dbReference type="GeneID" id="22575257"/>
    <dbReference type="KEGG" id="lpan:LPMP_230530"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230010900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_230530"/>
    <dbReference type="eggNOG" id="KOG1616">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="531008at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002894">
        <property type="entry name" value="SNF1-related protein kinase regulatory subunit beta, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006828">
        <property type="entry name" value="ASC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037256">
        <property type="entry name" value="ASC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343:SF84">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04739">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01010">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160219">
        <property type="entry name" value="AMPKBI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Association with the SNF1 complex (ASC)" evidence="3">
        <location>
            <begin position="137"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN98504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="278" mass="30651" checksum="EAABC866F0D489EC" modified="2014-11-26" version="1">MSRSSLPRPPTDPDSTAGGMTGNVPAITFPIVLRYQDQDVRALIEARKSVYVAVEAMSWQPLPMTPSTDSFYALLELPPGNHNYRFLVNGMEVVDSTQPLAPGTASPNMPVPPQAPSLPVGLAVAQPLPKPVAARDGKPANTIFLNDVLLTTKEDDDIMDNGEGWGQEPIMFEESRKYPPIVPLHLRYTPLNTPPTLVRCSRDGRMAVMDTGGEHNSRVPPEHLPLPLSVTINHVYFQRREDHAVMGVTTRYCNKYTTVVYYSHLPANPIDSLESLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTD9</accession>
    <name>A0A088RTD9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_230740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699231.1">
        <property type="nucleotide sequence ID" value="XM_010700929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTD9"/>
    <dbReference type="GeneID" id="22575278"/>
    <dbReference type="KEGG" id="lpan:LPMP_230740"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230014600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_230740"/>
    <dbReference type="eggNOG" id="ENOG502RZV9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273204at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="940"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="953"/>
            <end position="967"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1136" mass="120933" checksum="BDC429ABE12DBCA9" modified="2014-11-26" version="1">MSASPPLLEAASGEAASTLQGRFPGGGAPRGGLPSSLPSHRDSSRSPYTGTRHSVPAFSIERPLAISPLALALQAQWRQLQQDMLSPSALRPEHGDSHTVQVEEDVLRVLGSIAARADMAVNDAAHTVPYLLALGQVPLPSLRTQVVALAALRGVLSSLSGVYGDEAAAAFVHDVLLGEHQALQALSLATLAALEGLEDATEMHDGGLTRADGHSRTPPSLGSSSSTALLSRRGRRSLLSRGQGDTQAEGGTLRGARVYPEGPKVAPASLPHSTVASLCVNDTDASLDKSVTLRGRVVHTTLQLLRETAEMCAPVTDALLSSGALLKACIDGLHRLPHPPPPLAENAAGLAGGLPVGNSETLYAAHFHRCEDVVALLLTLLNAEVTRHNEASLVLCSFDAHRAVCALAQRLVHTALFASSAVCEGASAGGGADASMLLWSALKVLGRLTRGCPSAMRLFLSENTSLPGFLIQVLTVSVAEVREAGALWAAALLETQPQASTELVSGLLADAVSLSLTTAPTSPLKSETLSSSAPVPTFMASLMEMLHWRGPQMHVFGVSAILCWRWLLLSDPSRVAALLLRDSSLLATLIELILRGEDFSSSPSSAALSTRLTALEALHVLALSYALGSLDTRAHLEAQVVRGQLSQTTLRRLRTNAHAILERTHPAYWNAFPAMEVELLEGETELSEEMRLAGATVCMRGAVEMTRGTGASGPSASSVMRRRGSRERLAVCISTGAAWRQLVLESMWELMVGAMAADDSSAAVVMPSSAHASVTRSCTVAQQQQQQRPVKAHFSALHPPTRVSAGGTFGTSPIRVLTSASSLLATTGTADLTGCTIVEDTGGGSGAASLLNLSAHPTLNRTPRTIREATLLPTRQSTTVFRFRVVQQAEGLGGLFVQDSMRVVLHLAQHYIQAPTSSSTSSQASSNLIRAAKKRRGCDGLLHRSLPGKAPQSRSRSTSPPLPLGLSASVATSSPSAIFGTAPRFVDTSAWRAKERNPFIPVTKPAEVRQAELKRRQWGVKELQREDVVLFLVHYSHLMTELPDAIAAVEDHLYYLRRQLQLCPTREVRRRCELNDLYMNVYPTMHLFLRYIDQQARRSRSVLQLLSTYNGGTIHSGNIVDVYDAVGRCTGLSATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTK4</accession>
    <name>A0A088RTK4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cysteine desulfurase</fullName>
            <ecNumber evidence="3">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_271050</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="3"/>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700194.1">
        <property type="nucleotide sequence ID" value="XM_010701892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTK4"/>
    <dbReference type="GeneID" id="22576283"/>
    <dbReference type="KEGG" id="lpan:LPMP_271050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270017700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_271050"/>
    <dbReference type="eggNOG" id="KOG1549">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250117at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990221">
        <property type="term" value="C:L-cysteine desulfurase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000003">
        <property type="entry name" value="Cysteine desulfurase IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000002">
        <property type="entry name" value="Cysteine desulfurase IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00331">
        <property type="entry name" value="Cys_desulf_IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010611">
        <property type="entry name" value="PRK14012.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601">
        <property type="entry name" value="CYSTEINE DESULFURYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="10">
        <location>
            <begin position="2"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN99487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="395" mass="43341" checksum="150A06C379430FF7" modified="2014-11-26" version="1">MDNQATTPLDPRVLDAMLPYMTEEYGNPNSRTHQYGWSAEEAVEKARKQVASLIGASPKEVFFTSGATESNNIALKGVGNFNKAKKNHIITLQTEHKCVLDSCRYLEMEGFEVTYLPVLRNGILDLKVLEAAIKPTTCLVSCMTAHNEIGVLQPIREIGALCRSKKVLFHTDAAQALGKVKLDVNTDNIDVMSMSSHKIYGPKGCGALYVRRRPRVRLRSPVSGGGQERGIRSGTVATALVVGMGAACEVAMKEWKRDAAHTEKLQERLLNGLKSRLSHLVVNGDLKHRLPGSLNISFSCVEGESLLMGMKDVAVSSGSACTSASLEPSYVLRALGVDAENAHTSIRFGIGRFTTTKEVDVVIEDCVRNVERLRELSPLWDLMLEGKTLTDVQWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTR2</accession>
    <name>A0A088RTR2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_270230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700110.1">
        <property type="nucleotide sequence ID" value="XM_010701808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTR2"/>
    <dbReference type="GeneID" id="22576199"/>
    <dbReference type="KEGG" id="lpan:LPMP_270230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270007800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_270230"/>
    <dbReference type="eggNOG" id="ENOG502RZU9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="274902at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="187" mass="21669" checksum="4A90AF38A171C6B0" modified="2014-11-26" version="1">MSSGALGRGSFHSVVAGVTPRRIPTYYNSAYDLIQLHRTHREVTRGFLIRDKVFDNKFPGCSLANGLFKMVPNKRDNFHTRELTELIRHRTIWTQRIQQQRTINAAILEDAAKELSPAQMEDRFSYRTPDTAAYFTPQEYTAANNWPNYWQHPTEKHVVPRPRWRREAELGGITRVRDAVATPVADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUQ4</accession>
    <name>A0A088RUQ4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_272410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700327.1">
        <property type="nucleotide sequence ID" value="XM_010702025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUQ4"/>
    <dbReference type="GeneID" id="22576419"/>
    <dbReference type="KEGG" id="lpan:LPMP_272410"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270032000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_272410"/>
    <dbReference type="eggNOG" id="ENOG502RZYZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276683at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="385" mass="41189" checksum="DC6D3FFCB12477A0" modified="2014-11-26" version="1">MPSAATLSIDARKWAETIEEAGAECFCSAVSAKNVTHVLSTATVRAPQKQLCAAVSNFVPAMLESVHGVSILTALVRYGTTATVEQVTSKLLAADEGVWSFTAAPKKEMTKCLSQLLERLAYREDCTGESHKALFGSLKAVKKQALMTSPFTLPATARLALVDDAFAAALLSSSEAQRALGRSCQDAATAAAAEEFCCALFERAADDAASDFVWKALAANMKPDAKAHPREAILALLASHAPVPLVNKVTSAMAQWPTVRDLCTRDSYAHIVAHLLERCDDERAGNRLVAAVITQEADVTQRMGARKAAQHHLLAALTAKPSYAQALQKRLGTSQTKRLAAAKMRFANATQPKAITTQRVILEKLKKLRSTATSSFGAGVKRARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUX8</accession>
    <name>A0A088RUX8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-editing substrate-binding complex 6 protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_280340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700377.1">
        <property type="nucleotide sequence ID" value="XM_010702075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUX8"/>
    <dbReference type="GeneID" id="22576479"/>
    <dbReference type="KEGG" id="lpan:LPMP_280340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280008800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_280340"/>
    <dbReference type="eggNOG" id="ENOG502RNDP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="246783at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="CDD" id="cd23734">
        <property type="entry name" value="RESC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058917">
        <property type="entry name" value="RESC6_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26188">
        <property type="entry name" value="RESC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA-editing substrate-binding complex 6 protein" evidence="1">
        <location>
            <begin position="877"/>
            <end position="1101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1159" mass="125010" checksum="7C884A37803F572C" modified="2014-11-26" version="1">MSATITQLVRRIAAPAVAASLMKEELCLALAAVAQLRPTLSIATGERATASPLSTEALAQRSLRVLPRCAPQEVRMIAHGANALQWFLTPSLLLIDALARTLYTHIVKWSQPATEGKSVAKHKVRLSDILAVIQLATEAQRYFDATIFLLATQHAVEVGGQSTDMSAALAEEFVAIVCGYAGEEDGAAAVGRLVARLEGSPTVASNSPGLDVLRASVRDRPLKVADRWMVSYTQWAQQRRSVLETVRAPADAAAATHTEGGTVRTPIQLLKARHDVWQVVLALLAEKEYVTDDRLQRTLEAVRLLHIQDPVTLSTLDRTVALRAMSPTLPSAMLTNYENFVYAQAQYYPHALAALKQGDAVTAAAVTGAQEAIGARSSPSSRPTAGTLQHVSVIQRVYRDAVAGAVVSEKDLFQLSTTVDTSSADEVAMATYVFARGKELPSDLLMWLPKRLMSLTLEGVVALVRAGRHDRRGALARVLPVCLRNSVHLQECILSAPTMVLVELVEALGRPLPRWTAPSDQASSLEEQVFDMVVAHLLLQVEQMPLPALLSVMKIGGCRLARTDDLMQAVCGRVADHLVAAVTPPSISLCLEVLASLQLGNCRQERLLDLLADAIAAHFSPMSQLTTSADAPRLAALLRFATTQLKYGSPEMAAVGTNLLQRVRQGDWDSLPPEALVAAALFALDSSTLVSSAVSLELPHAVVAHLVAAQRLASTVTVDLAIALVELLELIPTVDADHAQALVTCVLPVASALSPPVVARLLFVRHRNSIAAVAATAPSADVAAELYTTVGKHVLGLPPETFTALCVVAARPGFEAALANLLVDMLPLMADALSAHQLSRCVFGLGEMADAGQRLSHQVMTEALSDYVVDNLELFTSACDIATLLHGFAKLQCTKRHLYSVFATQLLRRPIKSTLDFRSISLLFFAFGSVRFVNKDLMDLLCRVFVAHIDSLAAPDVLMSLRGLSRMNLLNDSFYRKLGMKATELVDEFPLQAQCDLLHAYGAVEEAHPKLAETLSKRIAAAVESLPSVSVATDVLTSLWLMGTNMVTNESIETIVNYVVRNASELTGSDIRKLCSITLNQNWKHPELLHGMAARAIALQEEQQLEATTARAVLDTLSSQLVFHQAARVQLSHLARTVSKETVLLSGEEQEQLNLITSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RV47</accession>
    <name>A0A088RV47_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_290870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700695.1">
        <property type="nucleotide sequence ID" value="XM_010702393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RV47"/>
    <dbReference type="GeneID" id="22576851"/>
    <dbReference type="KEGG" id="lpan:LPMP_290870"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290012900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_290870"/>
    <dbReference type="eggNOG" id="KOG4206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277802at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12246">
        <property type="entry name" value="RRM1_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000824">
        <property type="entry name" value="U2 small nuclear ribonucleoprotein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="6"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="114" mass="13381" checksum="E55ADE278C28E84B" modified="2014-11-26" version="1">MEEPKQTLYIRGLPDKPSANEVRRALYLYCTQFGPVKAVLYSKSKEFYGQAFVVFTDVGTATTARRSLHDRMFYGRQIQAFYAHKQAFCVAPGERRRRDLAREKKRLRTLQQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVL6</accession>
    <name>A0A088RVL6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Plastid-encoded RNA polymerase subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_290140</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">In plastids the minimal PEP RNA polymerase catalytic core is composed of four subunits: alpha, beta, beta', and beta''. When a (nuclear-encoded) sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIN99965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700908.1">
        <property type="nucleotide sequence ID" value="XM_010702606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVL6"/>
    <dbReference type="GeneID" id="22576778"/>
    <dbReference type="KEGG" id="lpan:LPMP_290140"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290006400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_290140"/>
    <dbReference type="eggNOG" id="KOG1522">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270173at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001514">
        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001988">
        <property type="entry name" value="PRK00783.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="7">
        <location>
            <begin position="18"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN99965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="337" mass="37443" checksum="45BF27D6A37A5CBA" modified="2014-11-26" version="1">MKLEIIECVRKEHAAGETLTFQLNEVDSSFANALRRVMLAEIPTLAIEYVTIRQNTSVLPDEMIAHRLGLVPLFSEKAKRLNFPQDCGCGGSGCPDCQITGSLKVQCPPNQHSKQVFIGDSLQIDSAEVYPVSAEEHGIWLVTLGRSQVLDLNVLIRKNIAKTHAKFMPVATVAMRYAAEILLNPNGFQALGKTNAREWVARCPRNVFRFVERTGQVEVQDEGACIFCRECTSQEPPFDKLPEPLVFVRQRKSKMGYFDFTFVVESTGVLPVLQIVYDAVAVLRKKLQRVSEGLMKNPNADGVMTRTIGQSTTAPVVPNADAVRKGAEEDNLDFTMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVM0</accession>
    <name>A0A088RVM0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tryparedoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TXN2</name>
        <name evidence="2" type="ORF">LPMP_291180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700726.1">
        <property type="nucleotide sequence ID" value="XM_010702424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVM0"/>
    <dbReference type="GeneID" id="22576882"/>
    <dbReference type="KEGG" id="lpan:LPMP_291180"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290016000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_291180"/>
    <dbReference type="eggNOG" id="KOG2501">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="409136at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030178">
        <property type="term" value="P:negative regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03009">
        <property type="entry name" value="TryX_like_TryX_NRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000288">
        <property type="entry name" value="Tryparedoxin 1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045870">
        <property type="entry name" value="TryX_NRX_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46472">
        <property type="entry name" value="NUCLEOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46472:SF1">
        <property type="entry name" value="NUCLEOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13905">
        <property type="entry name" value="Thioredoxin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="13"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="148" mass="16921" checksum="2D969841708ECC73" modified="2014-11-26" version="1">MSGLKRFFPYTESFLRGSATDITLPTLAGKTFFFYFSASWCPPCRGFTPQLVEFYKAHAEAKNFEVMLISWDEAADDFKEYYAKMPWLALPFSDRKGMEFLRTGFKVESIPTLIGVEADTGKILTTQARNMVVKDPEGKEFPWPNVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWB9</accession>
    <name>A0A088RWB9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_292440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700848.1">
        <property type="nucleotide sequence ID" value="XM_010702546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWB9"/>
    <dbReference type="GeneID" id="22577007"/>
    <dbReference type="KEGG" id="lpan:LPMP_292440"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290026500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_292440"/>
    <dbReference type="eggNOG" id="ENOG502RYU7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267457at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37028:SF9">
        <property type="entry name" value="NUCLEAR PROTEIN MDM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37028">
        <property type="entry name" value="UNNAMED PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="653"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="697" mass="76879" checksum="F894F93C23BF75FB" modified="2014-11-26" version="1">MASSLEIQANGDTVGGTATLSSRRLFQERINALLSAPVPLCLQSEPQGDSSFRTGYMSVAEPVGSGAATELSLHGAPSSKRNAATSATHPLPIYEALLQKGRLMQEHRERLRQEAIEREMREVRPAPRVPISPTPVPVQAPRSARRVPPQGQRIEDKLLQRAKEKHALEEKAVQMRAEREAEDLAVIAPFHPHISAYALATKSRYKEPPPDRAAWRARRLAELTQIRKNSEAEALEELQDVPSINPRSAKLAARRKAREGLDGISVPDAFLLGEHRRRLAQWKVAEAEREAQAHAGPSITRHAANMRRIGSVGDRLHAESYQAAIRRLQREMTWREVHTPFQPLVTSLAAATAPRYQRESNIGVHTKTLEGTRSFSRQSSTPRDSFQPSINPVSAAIAQRLPETAMERLCRPSALHSLASYVDSSSFMDASGVSPSPSLAARSQTRRTLLCTPSAHQQQGTVSNTPFSTPEVLPNSVVVSLDAYERRRQRRLEALRKEQAEHEQRECTFQPQINAHSSSLTGAFTSSSGQRGPNAVAQRSGEWLQHRERHLETMRQWQAEQVAAAEAIAARRRSSVSTATASSSTLSYSVYGGDGTPWGVEEYLARQQLARTRRQRAEETLDRQSVSVDGRSHTSLSSAPPPARTQEGLAHHVQNSSTRSQTPSPILSFRPAVFESQHPSVAPMFVSTEDAPSSGAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWC0</accession>
    <name>A0A088RWC0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_302400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701263.1">
        <property type="nucleotide sequence ID" value="XM_010702961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWC0"/>
    <dbReference type="GeneID" id="22577293"/>
    <dbReference type="KEGG" id="lpan:LPMP_302400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300028300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_302400"/>
    <dbReference type="eggNOG" id="ENOG502RXUJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="433738at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="701"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO00463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="780" mass="85265" checksum="3894FBDF8EB8927F" modified="2014-11-26" version="1">MWGTFTGGEAKLPLCNSNDDDSSSFCDGGKDGVLFVPDPIFDLTSLQQKAVMPCLTQDELPLGATVWVVDEEDVATQLACNFSTSYLSVCNGRLSGEIVRHTGQMTLVRFHSKASDLHFSLCLPTSCLSLQPIEPYDSLPHHSDSYGLSSGAYGMLGPRATCRERAGSSGHDGCVGQCLFEAMPAYDFEKVRGTTLEKAQEAFFGGTFEKALRSVNKYIETQPMSPTTSSCTATDPNSSLSIADDTAPKAAALVDALILRSRILVFLERYHEALDDARRCIQLEPSWVRGYLSLARAHCGLGQFSEAAAATTNACIILPYSLELERIRELNNHMHYLQSQLRAEKASCFLVLDCYYRKRLFVRTPVPAETLLCAEGTPIVATHSVFVAKEPPHRCPVCFRPFSTSERPSSSAADPLSAVLATAALSTPTTAAISTSLPSPRGTDVEDDVEYCSTECTQRASLYRPLESKHRAPLEEVRSLILSKGAITLNVLPLEMAAMTVRLFLMVVTIHRRLSAKRRLEDSSRRYLDSSAPCCSRDKTHTWPEVDAHGSGALSNAHCPSPSPPVRLETSLRRLGVYPLCTEPIASSKLDELKIVYDALTVDFKAEDRATFSYEVFSRLYAYVSAYFTPVELHSLQSLDSPGGASAPQTVFYLPHYVGCIETSRVISYTSGSRRRRSNERVAPAEGELLDSRVMERPSMSDIAASSSMQSSTTPSHLSSPTISTSVKNELFDVSNNEANCVVRMGPHPGLLELVTVVPVNRERKLRCVPLTVALDSNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWE9</accession>
    <name>A0A088RWE9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_301170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the importin alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701149.1">
        <property type="nucleotide sequence ID" value="XM_010702847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWE9"/>
    <dbReference type="GeneID" id="22577171"/>
    <dbReference type="KEGG" id="lpan:LPMP_301170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300016800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_301170"/>
    <dbReference type="eggNOG" id="KOG0166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="29145at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000009">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032413">
        <property type="entry name" value="Arm_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024931">
        <property type="entry name" value="Importin_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16186">
        <property type="entry name" value="Arm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005673">
        <property type="entry name" value="Importin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="127"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="212"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="297"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO00349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="539" mass="57959" checksum="71ED9B0422C7CB20" modified="2014-11-26" version="1">MFNNQEKKGAKQAVSTKAGAERRQRQLMSVRHKVHGEVMKHLRAEDQEDLAMLDGNGGVAQVSNPEDVWSYDARSTPASVPLQLLPTLVNMCMNGPTDREVFQGTLLIRKILSVEKDPPYDAVTSSGVVPHLVGLLQREDYPELQFESAWALTNIAAGTSENTMMLVACGAIPRFVALLGSPNADCRDQSAWAIGNLSGEGAACRDEALSHGAMAALLNVLSVKEQPIHVLRNATWAVSNLCRCKPLPPLERVAIALPTLVDLLNSSDDQLIVDAAWGISYISDGPAERVQAVLEAGAVPRIVQLLSVPSTNVKLPAIRIIGNIAAGTDEQTQVIINSGALPAMAELLRHPKRALRKETCWTVSNIAAGQAYQIDALVNSNVCIPILECLSAPELDVKKEAVWTIANITFCGSVAQVKYLVNIGVIPPLCEALRTYDPKIVTVALEAVQCFLQVGEDEKTSGGMEENIVAKQVMDCGGVDSIEQLQTHADKNVYNIALQILESFFTTEDEAGQMDSAMGAGMVDFAQGNPNVGGGQFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWN7</accession>
    <name>A0A088RWN7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_301310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701161.1">
        <property type="nucleotide sequence ID" value="XM_010702859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWN7"/>
    <dbReference type="GeneID" id="22577185"/>
    <dbReference type="KEGG" id="lpan:LPMP_301310"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300018100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_301310"/>
    <dbReference type="eggNOG" id="ENOG502SGN8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="262193at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="352" mass="38797" checksum="EBE17149210F4E31" modified="2014-11-26" version="1">MRDAYPPPTATASLATQFSIYCLEKPKQTMREGDTAVPACKSAPTSSPSKANLASPLSYLDVVQQLDGGVEWSFAPYPPCSRAQLLQVHTYWVAIPNSATTETQRTIELKVNGGASEMPKDKESASTNSLEEAITAPRCSCGRDDRFPASSWPSVRAPRLACVVGVVWVRLSAGTRFACSLVNRRTPHSGHASASSTTATSSNIGMCRPSVEGYIQVVLTHPHYRRRGLASWLLTHCLARTEVPAGVFASDGSDGVAYTIQRWHLHTLAVARRAEKRPHDDDKATRGWAQDRMQPQQHRQDANPGKSERECNEEAIVATLAMYRQLGFHERRYLARYYSGQNDAVELMKMCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWP4</accession>
    <name>A0A088RWP4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_303660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701388.1">
        <property type="nucleotide sequence ID" value="XM_010703086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWP4"/>
    <dbReference type="GeneID" id="22577419"/>
    <dbReference type="KEGG" id="lpan:LPMP_303660"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300041600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_303660"/>
    <dbReference type="eggNOG" id="ENOG502RXAU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276840at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="443"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="544"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="856" mass="96392" checksum="D8685447F2C17172" modified="2014-11-26" version="1">MNFNQPGGGAEENLKYPSRSKQDEVSYEVSMGDGYTTEMVTDPNAATPEQTQAENETAATQSNGYDHGMYYDPSSYLHYYYQADDGNYYYYTNPQEDESNTMPQGLNVPGMQTAENLVRSYEYASYDPPTYNWFVDIVVDTFLSKPFLVYLTILLYCAAAFMGALGLNYTFAILYRLFVPPIPNANKVLQPFAYFALFFYISFVIVTVLCVLMDMVRNLWMFKRDDVIFWGMSHRYFSKRKPPYVVLLLIILVVVFLPLLWGIIEAGVKRQSLVYVAQRYAFVAVLAATFLVVICYLWFYWRALVYKWLSIRKRAERDDFELRRRAYKHKPEKMKKVHWYHASTVLEEFGMDRDTLLYNSVVFTIGCVPLFAVYAAQALSTFPGTPSLAWPAIASISLTCVYVLSWLTVLRRKNQWAIYASLALIVVMLILGLGGGAIGGRPATAGIVAAFFIAAHGMISRKRKHSFTKKELHATLKLPYNALADEKPQGCRIDTYLFCCRSLFLDYMKCCDVKKHFGYRHPDVVEAERRFMISHVALRTDQKALLVWWVIVMLAVAFVVALSRSTQYRFTTQIAIAANTSVTGITPFIPLCEKVFNANGSAPLRMLDLALLAALSHTQGNTGDADFATWFSSKPSLLRMFPAVMPYAPSFAVDETNISFSDYVDVSSRFHVITLNSNNRGLSLFRDLDDWGESIALQAAGAISPLINIWDEQSRGTFVQRARFLKNWLPPSTALDTVKAYIAALNSSGVSSGILIVGDQFSGGYAKKLSAELNLPFVAFNPPGTKYINNFLANGTQLSATRSLWSYVDSLEDTTDTTYFLCNVSLSSNRCGRISTVVDYLLRTCGDPAGRSMNQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWR7</accession>
    <name>A0A088RWR7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_301660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701191.1">
        <property type="nucleotide sequence ID" value="XM_010702889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWR7"/>
    <dbReference type="GeneID" id="22577219"/>
    <dbReference type="KEGG" id="lpan:LPMP_301660"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300020800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_301660"/>
    <dbReference type="eggNOG" id="ENOG502SJEF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267101at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="352" mass="37397" checksum="278D3589EB2375BF" modified="2014-11-26" version="1">MLTLFSFLYFHLKVRIMVKKASLTKRSAGDVATPRPGETAATSVDSTLSPRTFRQHKWAKRVDDAVIAMGHVQQSLQQHTVEVDTVKRELEELTYTAAALWAANPDELPAQYRAKQQASSQRTSNSVGSAPRSTNTTPTKRCSGSDIASLSASPGGDAVSGISGTGLESVEQTLLQLSPAQRAKVSAALQLLFYAPPIASSVEVVMDGTDADVAGDLSATVADRAAQEKSAPLAKSGNAESAVPAPCAVVSPAMVTASNSRISTAATGRRNGIPLALFLAMQELRTRRIHLEAQLTTAANATAQQLERFQLLQEELMVSQYGLEAARRDPQQGLQQQLAGQQTPSESIPTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXY0</accession>
    <name>A0A088RXY0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_312700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701654.1">
        <property type="nucleotide sequence ID" value="XM_010703352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXY0"/>
    <dbReference type="GeneID" id="22577696"/>
    <dbReference type="KEGG" id="lpan:LPMP_312700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310035000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_312700"/>
    <dbReference type="eggNOG" id="ENOG502RZT1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277808at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="29810" checksum="CAD0CCD5A8D01793" modified="2014-11-26" version="1">MSDSLPGALCFVSLIVFFVADFFYAKKLNEQKNAHPELDDCAPSTSPDLDTIAVLDSLTSTAIDLYHHERERFTGVAAPANSREYVAVGENGVSGQPADSPDLGDPAGKKVMHTMVVVCSVVAPVLTVLLVLMPSLFGWTQFGVHSSLSYLAAVPGMAATAFYVVRSYELTQVFEATKAEWISMMWLRLDVFFVMSAVAFFGVGAWVVASCMLTVAFYLAHRLMKMEKQLNRVQRHTQLVRDEVDVTRVLVPGTEESKRASGINDGYSALASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RY16</accession>
    <name>A0A088RY16_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosomal passenger protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CPC2</name>
        <name evidence="2" type="ORF">LPMP_321730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701858.1">
        <property type="nucleotide sequence ID" value="XM_010703556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RY16"/>
    <dbReference type="GeneID" id="22577914"/>
    <dbReference type="KEGG" id="lpan:LPMP_321730"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320022900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_321730"/>
    <dbReference type="eggNOG" id="ENOG502SB6J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270789at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="215" mass="23369" checksum="C1406676D5FA09DF" modified="2014-11-26" version="1">MSGYRSDIDPFKEIRVLPREVAQLRHHLSRINHALQTKYFVAAELSELALQPDKSDEFLALYTGEIHRVVARLNKNAKRQYTVRVDPLRLTSGFDFQRAADHKGNLVEGVTPGNVEGLTSPEVDGKWTASLVETGKQLAQQQAIEARRQALAVALQSTPSTQQTQSVKDGGGVEAAGSGATGGASTGAIDSDVRKANKESFLFSTPPEFTGFTPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYI9</accession>
    <name>A0A088RYI9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ADP-ribosylation factor GTPase activating protein 1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_321300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701816.1">
        <property type="nucleotide sequence ID" value="XM_010703514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYI9"/>
    <dbReference type="GeneID" id="22577871"/>
    <dbReference type="KEGG" id="lpan:LPMP_321300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320018300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_321300"/>
    <dbReference type="eggNOG" id="KOG0704">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030100">
        <property type="term" value="P:regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08830">
        <property type="entry name" value="ArfGap_ArfGap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46395">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46395:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="12"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="152"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="280"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="367"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="152"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO01016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="408" mass="44062" checksum="925DFB7957662C20" modified="2014-11-26" version="1">MTNHTYVSPEDERAFMAILAKDLECSRCFECGAPSPQWCDVMHGTFICLNCSGQHRGLGVHLSFVRSSTMDGWMNWKPEKLRQMELGGNRRARLYFEAHNVPKAPFRNRYESLPALRYADMLESEALDKPFSEAAWQPPAWYARLKAAESPSEGSPTSAYPQTNPTRFAGHGSNGQPHAMSGNSGGGSEWYSALYSGWSTVSQKATELAQHATKAVQSADVEGVRTSLAQRWAGVSATVSTYATDLQQRMAEGGRDMNVPGGDEDDGLAHMLHNVRQVQAENGVDNTPGGQSRYGPVESSSSSSYGPGSRASVQARPIGPTSPESSKVYQGRILMQSACESAPTASVASSMSPGWRSPARLNHNVTLSSTELKANRPVNPLGGDGGSAPSAAPQLPAKDNWSWEDENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYU9</accession>
    <name>A0A088RYU9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA-binding protein RGGm, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RGG2</name>
        <name evidence="5" type="ORF">LPMP_330300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702123.1">
        <property type="nucleotide sequence ID" value="XM_010703821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYU9"/>
    <dbReference type="GeneID" id="22578183"/>
    <dbReference type="KEGG" id="lpan:LPMP_330300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000012900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_330300"/>
    <dbReference type="eggNOG" id="KOG0105">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1099063at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000683">
        <property type="entry name" value="RNA binding protein rggm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF50">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="65"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="157"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO01323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="183" mass="20077" checksum="D4CFC6E6207B275D" modified="2014-11-26" version="1">MRGSFRRGRGGSGSGGGVWGQPAAADEDAWNAAPPSFQPPVRRVDPLTLTAVEVEVDGVKKLVGQRVQVSGLSDETTWHTLKDHLRQAGDITFCRLFSGGRGMVEFAVPEDAARCITELQGSELEGATLYLREDREDTVLINTRRKIRDARDAQLRARKEEAEKVRRERAMAQGDVSSDSAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZK5</accession>
    <name>A0A088RZK5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_330980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702191.1">
        <property type="nucleotide sequence ID" value="XM_010703889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZK5"/>
    <dbReference type="GeneID" id="22578251"/>
    <dbReference type="KEGG" id="lpan:LPMP_330980"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330014400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_330980"/>
    <dbReference type="eggNOG" id="ENOG502SE45">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267658at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="523"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="550" mass="59057" checksum="DA8596C162527753" modified="2014-11-26" version="1">MPSPSPFSSSVFERLSYSQRGTGKNRGAQSLARRSQELGAQLCGRLSQMSLEVNSAAFGGTATIAADVGAAARDADSPLAPSFSSPATAPLCFMEDVHRDLSAHYGSHAVRRGLAKPLGPCVHPVIRKGRFAAQSTGMHSPLYMRVWLLRLVRRCWCPRCGVWLTRGSTPTHTEVKASRTILATLKECRVRRQLRSSRHATTRGRFMLCCLRCLDTAQRAAKRHTSLSEIATSEQQRKQGADRNTAENVSLSTRRAAREARATRVERALKALLAEARVPRRNRRCRRRSQRRRRDSKEEARKGAKVAVHADSGNPAAVLQHSSSASQVTHKLALSLVHKTTPLAGIAGSGNTTKTSAASLPTTARTAQKSLQGLVPSGPLKKSALRVSAMPPRQQSPKKLPATVSSACEVSMVTAEPAVVVSSTVRIPPPLPSSSINISGAHAPITDWPVEAVQEEEMKTASRTPGTSSKNTPATTSVSAPTFPFTDSRPSCAPPGPHEPPRPAKAIASTLRTSNTPKRAACPPAKDASTTKKPTTAKKKLMDTMNQLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S034</accession>
    <name>A0A088S034_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flagellar attachment zone protein 1 conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_333200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702409.1">
        <property type="nucleotide sequence ID" value="XM_010704107.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22578473"/>
    <dbReference type="KEGG" id="lpan:LPMP_333200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330040400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_333200"/>
    <dbReference type="eggNOG" id="ENOG502SI4F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267227at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056614">
        <property type="entry name" value="FAZ1_cons"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23398">
        <property type="entry name" value="FAZ1_cons"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flagellar attachment zone protein 1 conserved" evidence="2">
        <location>
            <begin position="1432"/>
            <end position="1520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="770"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="882"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="907"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="954"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1761"/>
            <end position="1889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1983"/>
            <end position="2044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2137"/>
            <end position="2157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="770"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="907"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="966"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1761"/>
            <end position="1770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1800"/>
            <end position="1815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1835"/>
            <end position="1847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1852"/>
            <end position="1868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1877"/>
            <end position="1889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2256" mass="243592" checksum="BA5EA6DC9879FFC4" modified="2014-11-26" version="1">MYMAHLYVCQSGPPRAYTAKNAGPGTYLDQVVDPERNGALRRLRSKVPTMKGIIRDHASAHSTQAAVVAWSGTSAQRWQSLTERCGFIETAEEAASQSAAVGAASLTSELEPVLQLSPHISLLPDSASGNAKSAASVIGNVKWPRPHFVPTMWARTHQAYGAALGGVAETAAVHHPYSDEQTFTASVGTRDAGAAHSSLISALVEAVKLLQQPLRSRPSPVVAPEPGAATPASFAFAQKLLIEYEKLSRDDLLIDFYVTYPTRPAVSSAPPLPPHSELPVAAACWRSPMRTVPPLATSTRLASEEQAIRGSENAKGVVSTGISSTGEWRRFRVVLPGALWSFVLRRHRHLLTRALRQDVESVLLPDEAVEIASLHASEVEIEVILTVRQPSGLQSQISTTLSCSFFAQTWEVYNVVSFFLSREVLPTLPRSVLWPTPLYEVTTSAGTATAHAALGEAASTLQPTTTPSLPLPAVLLKHQAPATSLTKASLPDITASGATSEVRRLLLLRVPLLFLAEDSGELQRLINAAPSQLRLALRRDAMCAASNVNNVQVQSWAVQPSGLYVELLLCCEDANGAHMALNAERAMDRCPFAETWDVIRAYATDLVPVTATVPNAMKRCASTPQHTPASERAEGSMMTTAHTEAKVMTAAAPQWEFPVRSASPFIEKVRQSWPQPEGAVLSGSTYAGSERYSVSTTDTVYRFVAGSGASLSGNYSEEGVNAGNAAVSSVAAISRHTPPVASLQSRITETMEAKRTPSVASAIAPRRVNTSAEVSHLGETNSAQPLLSTTFSTPKTQETGAPRANFATQTVQLPPRVCPAAEGVSLVTDVRERVAQALPASTEHSSEQLTPCTTVTKTTLVCPAAQVGKVLLPPCLPQPLLPTPRHSAQHPEAVGQESLASRIYSREEESATFLRNDKTRQTVQNNEEGGSFSRPHEPTVPLLRTAVVKQARAAPSAEISVTSSRHMTEDRQRSDQKRCSSLEINASAELITRGIGGQESNETLPPNGDTGLAMELEVEKADSDSTKGTCLSLVAGKKWQTLLAERPLLHQGTLQEDVHTWCGVPTTAMENVITCANKLHDEGMIALGMPLQSSSLAQKTETSTTDSATSSVFSSIMKQDPFVLRLRHMLDFDEQQAQRTRMGALRSSVASSTRSAAEATMHFRAIPSENVLDTSVKAVIISQLEAFSPLAASSASSPAQRAPAVHVELPGALQDRQRADDGDGVTQAALDDVEALRMTTIAHGSSLQVDFSVSSAALLGSRRPPPFRRELERWPPFHSSELCDAAALRAPARVHLRRFFVTPGLTEEKLVGQLEVARSLFLVETYAVLNTSDDVVEELHLSAHLTVDATVRVPNSHLIAEWSSALMEYDYPQLNELLHDLVARETSQAPPQVEANVQPEAMRRKRLLSSTTLLRPPTAGAALVAPKGGDISSHAVYVTGDLWREVIEQHADVLREALISDAIAVFSAVAVSVLRVITVPHGNDAVFTFLLQNHGTSSLRVVEDALQKCPFTEAWALYRRFRGTLRHPSYHQVLNDVYTVQLDGKVWDQVLMEHGDLLAETFVREVLECLRGSYGAAVPLGVGVTGIAAKPDGLTIAYDVASTELCFSVDRERVAHTVLAYPFLQLWKVYDTFILTHDLFKHTKRTHWLASHHLSTTCDVAEVPNQRRRSHIEPVLQMPLDLLESHPVTASLDDEVEKATSPTARSTQEMVKGPREYELKRLPALASVSAPPVSVVLPETAVVPRTRASLVDFTEAMENEHARVETRAENESLPLLPPQTFLSQRSQRREQPQRRHHHSAHAEHKWHDRQSRVKEPPTNTCQGGARRDAATESSTETEYEEGDEAVEDVPSWKSSEFVEQTAPVSPVSQLAGHHPPELSQSLQQSSPPLCSSAVAGLGVPDRAVAVATKAAPITCVPLTRSPLMTAPQSTAPVKRRPSSGAQPLPPCFRAPQNAASPAALSPSSVPIGVAVVSSQAPVNYTPLSPVKHTQRATSTLKKEYPSRPGPRTFGDEAACLPAQRTSPTRSRERLSSRPGSSTAGDEPLDALQPYTEAEGKAHGKLRAAHAHLPLTTLPPLLNVFSAAPIKVLDVRMTHSPMVAVPVTAPTASSIPTPSPPQQTVHHSGTRTVPRVLLQGSQAKNASRDSYSAPGLSSNGPTLSHDSCSPLMLTPTSCSFLHGNTATMRSRVTSALPVPPLQGGTMRSRHLTPFVVVSTEPSRSLQKLWDDVDSVEEAVRTRFPRMKRELMATTTAMLLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S078</accession>
    <name>A0A088S078_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter family-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_333160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702406.1">
        <property type="nucleotide sequence ID" value="XM_010704104.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22578469"/>
    <dbReference type="KEGG" id="lpan:LPMP_333160"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330039700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_333160"/>
    <dbReference type="eggNOG" id="KOG0055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="1201"/>
            <end position="1298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1436" mass="157701" checksum="88F093EF4B50E16B" modified="2014-11-26" version="1">MSCKLLVYLSPLPALQVLISAITCLSSTCAASLRELLWLPQLRKGVPLSASVVVLTLVVTGLRLSKSLYFGNGVYLRHRAIFLEKIRAIVLRWEASCVTEVATCCADVDGQATVVLARYVGWRAANKICAWWAEEVAADVSSSQAPVASSVSFSGIVPSVAFSEDMPLEEMLELAYMADAVLRLGEDRRWLERLVTILQYILLRRVSLMEETQLYRRLRARALFPCHPATRRRRGGVWGDRDMQCRTWAAAWRLHHHPTWLAPHSGGTQFLCLPLSYFPVEAVLPYVACETWLNDRLVRTMLPRWERLCVRLLRQTHNSTSSVQGLNNGARTERMSSKVHYWFLRYTAPLLRTSVEQQRDAARRFCMEELSTAAGYDNTTVSNTPRSSLAFVWRCLIDSCTCSVSTLLTGSTAEGSAVPSAESTKLVRRVVILRAVSQAAVFTLQICYPRLSVRYVTEVAVAGVCAQGERSALSTEITTTNEAVASPVDTLLSSMAADMGWALVAGAAEVLLSRFTDVTGNQLSMLLADAATRRLQQELLCVDEAFYCRWLRTAPGEAGGMGDTGLTAAPGMRMSPVGMRPARPLITAEDVLAVGRRGGERVIALHDAVVKRSLRYAALIGRVAVTREWRPLLGAAVAAWVDVPALLSLFSVAVGYSTPSDVARLLSRREESLPTRSPVGLRLLLELLVDEESATTIPSATRQRRLPRLRHPYLALIACSSVWTFEHLLGEAKRSVSSLYAHVCQLKAVYAAVGVYQYSVTSVGGDTRAADAIAAMQEDVRCVLYYSVYQMERMCKERYGSDAGAASSLLHPLLDPEETALLQHPSALSYLPAHVDYFDLFSLPYRFVLRQLGLEMVFAYRTAVGMQQESRQMAEEWWTQALFHNAFNPLTSALQEAAQLTASCATVLLLCSQFVDGMWLMSPLPLPVLLQQARAMQTYRDLLRSGVAVQRLEDGVAPLQQLCEYLPRTVVSEASTLRHSPLQDANCSTENLSALQQRRHHWRQVLMVSRPELCFDTDSRIVGGLRLRGGVSWHHVYFAYPQLFVAPRVPDPGQKKPSCSCSVRPTLADACFACPAVGMTAVVGPSGAGKSSLNLLLRRLYDPVAVVELTRGGGMGRSHPDEQLGVYVDMNRIGTAADAEDVLVEVLRLALVESALPPPFNYEVAGLPSRFSTADRHSGTSQSSPTTSAPLVHSRRYCLRVQPGYIALDGIPLNLFAATYVRQWLAWLPQTPHVQPRQSFLSNVCGTAMHVTLHDVQKALRVCDCDAFMGERHRTLRDLVGPLSGGEAQRLALARVVAALLARSRVELLQGMPLHDSDGGTGVAAAAVGGLVLDEPTNKLDAISEHHLLAALAALQGIDSKTDSEAGARLPLFIWMISHRMSSLRSAQHMVVVEDGRITASGPSAEVVKTNLFVKTQLRLQQLTEASTSTLIDTTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0G8</accession>
    <name>A0A088S0G8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Serine/threonine-protein kinase ATR</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LPMP_321540</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701840.1">
        <property type="nucleotide sequence ID" value="XM_010703538.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22577895"/>
    <dbReference type="KEGG" id="lpan:LPMP_321540"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320021000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_321540"/>
    <dbReference type="eggNOG" id="KOG0890">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00892">
        <property type="entry name" value="PIKKc_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000065">
        <property type="entry name" value="PIKK family atypical protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000054">
        <property type="entry name" value="Putative phosphatidylinositol 3-related kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF69">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="13">
        <location>
            <begin position="2866"/>
            <end position="3182"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="14">
        <location>
            <begin position="3175"/>
            <end position="3207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="891"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1411"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1416"/>
            <end position="1427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AIO01040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="3207" mass="352401" checksum="58B0E9E3BB15056A" modified="2014-11-26" version="1">MEAVMEDEHLEPAPVRLRTESGALSVSNNKRSDSAGIRDELAGIGEQIKLLQLQLSGNLSPETKASEAVTQSLWGLLWRLRTFLFLASPSAAHQWNVGGALFDVYYGRHYGKDAAHVAIALRLYLVLLRFAVVCPAAALHGCLTLFGVLAVLNDARLRSWKDTSERLLEGLLFVSRALHRTERDAFAQLSNLVFELLSEVTAHFNSPAEESESALFLRLSIQPSAALLSQAEGLLPSVASTALESDMEGNMQQLEDAFSTCTCVETLYEARCIQACLLRLIVRLSEERLLVSLSPDRVGLLCDVACHLVSSAVPGAGGGVVNRVQHDAAWHTLRYFAVVDPRLLPHVQGPLILSVLAAQWSRQGSHTCTSVFDITVAEEALFEWCRCLSTAELDSLVASAQHRGGAGTDGQGAMRACLVQMWEVAVQWCSELYARPDTVVDDIVANTESGIRRSVSAMITLQQWVWFCERVFHSTVVQTSALAETMQVEEQKLLAAHSHHLQLLVNELPLSSFTASLLCTQLPSFAVESELTFLPIRILSFFNVPALAACVANVVDRAKNCIDVSAYRLLEANALAVQAGLKASSPIIRCDVAAFQGALTETLEVMHHHESPSYSLLIQAITVLMHAFPTSSENGEIHKSDTVARVMEKLESSISARRKGASAALGVAAPMWQMLDRETTRTLFRAGSGLGWSRRLLTLPPHAVTSAKAGEVFLCRAAGLAEALQRALAETMQRDGAWSSPLTSHSPLSTALPGATADSRQVAGRLQRAYESTASHFPIVAQLLQTLCALLTKLQWDAEWWRCRNHGKDGAYADSSGAAVAVESLFRSSSCILMLLLNIKYRFAAIAVPDMAQGWNGASVDAMPSRERSSTLRQPLAQAAMVVDVDDDDSAEDVLEGNEEAKKGRRHGKRTVGRALLSSKIGKTAAKGAASGAPQDGRLSQQCASKTKQLEKIVQLNRSQLLPALLAFTRHFRCDGKGGGSVLDGDEVQHGAMPATDRASSSRYDDTSALECSAVCLAHASIALSPPFVAKDVKGLFSLALARACKVTDPICYYALRELVLWSQQLTDPERTVGNAAMPPLLLVQLSGTERLLSAVLSARRNNDAQSIVESGAPILQLLWLGRRFFQRSCSAPSAASGEPDSKRQLLSLTAESVAMQEAWMTVSERVIQEGRAWVCLCFDLYVVYQSVRSTHDDTALAVMGLCIETARCVMALFAWSATDLLRFRERPFVFSSLFRAIVDKEDRDLKVVLTSSLDLLGRYVTSAGVDQVAGGTLAARAAISTVVPGDEATRAKLRHLMDQEKIADWRAVAGALAYVLYECGSKAVAKQMMYLAEAVSYIKKNIKDIPAVVRSTIHFVAFHIVSLEADAQMLAHDRTCRSGRHQRRGLSGAAPLHSPLAVLGGAANELFGRGRWEGGDDAAENTEEEGTSPPRDRITGELHAVEEDGGDALISKEVLDGISFSVFERALGQLVTLSEAAETPAGVESSLQKPVGRAVAAEELRKHMFAVLDAVYKAIHIEPAVAHRNEGASAANEEESSVALTVSPRTRRRWLLGLASFIRFMGPQTTPIALMLPTLLGHCARFPSLLPSVCIVWRELVYACTDEYLSESAAVIVLSLVSLEQDAALDSESKGFLLSALRHLYTRTQAAAFWDSYKVVLGTFSELVRLILRARHPVTSEAVEGSQESRRDSADVLLVGFVSVMRSGSLQSSSVFVRALYQYLDAADEATRRQLSHAAAGHPEVLQTLLRCTEADSESALYAMRCISILGAVAAPHASGLIDARCTTKTADDERRALLNLSSASGLDAWNCMTWTQSFYLDAETVLNWRKFSFTLLREYFPRLFASTADPVLHNCIAFAVQELIRASTRQERLQHKGVELRREDVVHVDELDRYLWWARLTPHVKQLLGGFTTTRYSLTVNWQTRLRTPEYTPSLGYRRWLFAFFNHLVMSCAGWFAEMVQPLRNVAKKNASLILFLLPYLVVHILESGKAEDVQYVEHEVKAVLEAAAGGPNVPVLSLRSQSIYEAPPESVSPEEPREHAHTVLSFLEDIEQLRWTLLRNRGRVMCVFETQEQAENLCIRLAEMYGDFLHGIPWSLRCRAALRIGSNIRALRSVESQRRIPGLTSVIDAVPLQRIFAALNDRESSRSIHRASPGLSLEDTAFSFENNGDWLSALGSSELVLQHRPHSGQHQLTALHCMNELGELYMTSRYAASLLTSASVLNGEEGGGKSTECLVGAAVKESSTFSQLLSDAPRGAAALSDFAQLRHHVQAYANEAAWRLGQWDTLLGSCTAAAAVSSRMPLVGPDKGQPVSLAMPAAHLQRALSGAGSLAWMRRVTDRERAKVVPLVRTPCQEDLTAQSYTLTLLLHALGDVDAVSQLCARAFVQHVSGHDCSADDSVVSQSSTPMMKLAAPLLPSSVKEEIANLLSQRAFYVEDTIAAREPLLALHRLIYRELGMPQKVAETWLEQSELLRNGGLGEAALTAARQAAFECREHVAETSYYALVANLLHDTQSPTPAMEFARECVGDVRIPATTRAQLQILLTNWLIETGSERPERILAEYDKARELDRTSELAHHQMALFYDHLHTLASNASEGAVAQLTAAATSPTSSGTTNMSAAAMYSAALQHQKEMVDSIQKYATRAIVHFGEALLRGVEKASVSLPRMLTLWLDGTVFLGGLLSTTAGKLDGTVSAALVEMNNRIREFVLSTVRPVIPPAVVMTALPQLLSRLGHPVAAVRTVLTDIVLHLLNHFPQQCLWLVLPMVLSKEGPKEVVETQIIAPFAGNPHNERVLRHSKFICDTLLTICNCSASLFPKEKGLTQLSPVQQITPMLPAAKFIVPVLSNLTPDIRATSNGAVFPTAPCFDRFDDRVVVMRSLQKPKRIWVHTNDGREMSFLCKAKDEPRKDIRMMEVAALMNSFFLSDPEAKRKRFSLRRYSITALSDDCAVIEWLNDTTPLAKVAMECYALDRSGVHISSVKKWVTLVDEKKISKMELFTKYILPEAPPVMHQWLDRTFASNQSWYEARKLFTQSTALWSIAGHIVGLGDRHAENLMIDMERGELLHVDFACMFDKGEKLEVPEQVRFRLTQNLTDVMGVLGAYGPFQATCEVALRCEMKNKSAVMSIIETLLHEPLIEWRRQNSRSHSSSGPKQLMERVARRLDGFLDLYSVPAQRDTLSLNVESQVAKLIHHSSDLNNLSQMYIWWMAWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0S7</accession>
    <name>A0A088S0S7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HSP20-like chaperone, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_342380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702664.1">
        <property type="nucleotide sequence ID" value="XM_010704362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0S7"/>
    <dbReference type="GeneID" id="22578743"/>
    <dbReference type="KEGG" id="lpan:LPMP_342380"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340029800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_342380"/>
    <dbReference type="eggNOG" id="ENOG502S0W3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272565at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="341" mass="38061" checksum="9351E3132B61EC73" modified="2014-11-26" version="1">MSGIDYSKWDKLIDSSSSSSSDDDTQHEFDRCDEGHRGGCRVPQVTRLKYPSRVILDSNGVRLEEAPPKALASPFCGATAPPRETHSDSVLGAIPFNDESSHAGSDTAAGNASSNSNVKTEGARSADQERLDATDDDEDLLYESLARNGGREGSHHWWTQTKDTVTVSFLVPWETKGKSVTGFRLYEARAATASGSELPYIHLETAIQVLPTCLASTSGGPPASPAPLHIHEVFRYPVKLSEDLIDGCWQLHFMPKRHLRLLVVQLFKEPVGLGMTLWWDRCFVSDTISVIADTHAIPDRMQQMKATPESKEKAEQFRKVWAEAHEEFRRRMQGRRREIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0Y3</accession>
    <name>A0A088S0Y3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_344420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702863.1">
        <property type="nucleotide sequence ID" value="XM_010704561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0Y3"/>
    <dbReference type="GeneID" id="22578947"/>
    <dbReference type="KEGG" id="lpan:LPMP_344420"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340052100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_344420"/>
    <dbReference type="eggNOG" id="KOG1084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10029243at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="248" mass="26821" checksum="657DCD53AC160123" modified="2014-11-26" version="1">MGCGRHHGARAAKPAKRVSFGPVTYVSALLIEASEGAYPHDSRRLVDALAPHPCVSGPTTVAIVAAATTPHAHNEVDELLGMRELEEYAAQPTLLLGSSVGRPHAMLWSAQQATNVVTDDNWKGGDTQDRTAVPPERAAPASSSGSRSASFDGVMYDTLVKSRPATRRYVDSAAKGQQRKDMRIVIFGFGKVGNVVAVGASSGERPWRLPEHPTEPFGCILLRYRPLEVAAARLKAQRINHARRTYRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S153</accession>
    <name>A0A088S153_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Calmodulin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_343760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702799.1">
        <property type="nucleotide sequence ID" value="XM_010704497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S153"/>
    <dbReference type="GeneID" id="22578881"/>
    <dbReference type="KEGG" id="lpan:LPMP_343760"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340045100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_343760"/>
    <dbReference type="eggNOG" id="KOG0027">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="62"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="139" mass="15650" checksum="9ED6A66E098C1BD4" modified="2014-11-26" version="1">MKEAFELLQRDGKIPKASVPTALRAAGLNPSEEKIKEIMVTATDVDMTGYEALVEKNDDKTDTSEAVKEAFRVFDKDLDGTVSVAEFRHIMTTMGEKYNDEEFRDLVQGFENNGVIHYEQFVDKMLAPFTEHGSADDTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S178</accession>
    <name>A0A088S178_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc/iron permease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_330120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702105.1">
        <property type="nucleotide sequence ID" value="XM_010703803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S178"/>
    <dbReference type="GeneID" id="22578165"/>
    <dbReference type="KEGG" id="lpan:LPMP_330120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330005900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_330120"/>
    <dbReference type="eggNOG" id="ENOG502S6CN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF209">
        <property type="entry name" value="ZIP ZINC TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="330" mass="34860" checksum="6E621BBFFBBF3EF1" modified="2014-11-26" version="1">MSSVGVWFPIFFVRRPRGERATTLLTAGARGRLLRTTAASATTRLWLSLANMLSAGMLLAMALLHFFPESLEVKSGTSPDSVALCGWMLVGVLIPAVLERSLQGGGAHSHDMVTDSEEEHVHARGSGSSVSASKLLIILMCCHGMTEGLLLGFEKDAAALLSAAAPLSVHKFCDGLVIGVSIAKQIYSETEEEFINDRADSEACARVSYSRNRFWRQLFEGPVGVWLLVTPITMICLIIFAVLLGGAAPPGARSDLNALPPAAPAERSTASRILPVSILAAVQAIGSGSFVYIGLTILSREELKGMASNAALLAGVGLTGALFHITSGYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1Y1</accession>
    <name>A0A088S1Y1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GRIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_332790</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702370.1">
        <property type="nucleotide sequence ID" value="XM_010704068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1Y1"/>
    <dbReference type="GeneID" id="22578432"/>
    <dbReference type="KEGG" id="lpan:LPMP_332790"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330035800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_332790"/>
    <dbReference type="eggNOG" id="ENOG502TBEN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="425925at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921">
        <property type="entry name" value="MYOSIN HEAVY CHAIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921:SF2">
        <property type="entry name" value="THYROID RECEPTOR-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="170"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="498"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="744"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1073"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1135"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="547"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="615"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="860"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="243"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="501"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="744"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1154"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1169"/>
            <end position="1193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO01570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1193" mass="129932" checksum="C9B319645B3189D6" modified="2014-11-26" version="1">MWREWTSKIKNFAENITTPDYDEEQRYNDGENDRDDVVENRVEDSHSLSLDERCSAHYRGDFSGTHATAHGHTNCETTYGDGDRFSVLKTSAQRLGLQCDELSVDRHAGAGGNADAAVYTQASPVSTEAAPSLSLSPSPLSRVTTLAGPLGSVGQTMASADAAVVTLGNEAAQRPSGSSGDRAVAAPSAPSPGSAQAGSTTAAEHRGTLLQSIVTSSSRLSTAQAQPLQRLSSFSSCSAALPSLPAQQGQSQEQTQPQPAPGLDAERAHLSGMHKYEDEVRATCASTVPHSEGKLREGAATIAVAAGETATWKDANAPLQVDALRAAHQVMVDELKREVAHEIALGARVRKLQQQAAELPESLAAAEEDTDAMKVTAAAAASAVSAAATTPDAASLLAEDDWRPCSFEALESLKEEVHEKRTQLQSTEVTRRFLPTPLQEAQTEVMASIMTSCDTSANGVREEQQCHRQLQGETDRLICELEEKRHCIAATQELLLNTQPQKEEPAAQVSNEHEFSKSTPAAVEGTSLSASARAAHEEERQRLVDKLTHGEAERGALQQEVKQLTETAAQLQQRLEAREHEYAASLAAAQAAQAESQKALLAKLNAVETQMLQSRQTCQEELQHMQAQLEGEQRRAKVLEMDTQAAQHARAAAEEQAAAAEQRGRSIQAELEAFQQQVKQRMVESEGKQSDADVSVTVLTQVKKQLESKVQTLEAMVDQVRRLSVDTLVRLGVDVEHILPMSLEHKGDAGRAHPGGDDEEDADKEDEKGGAATRTELPLLQLFSLLITESLQQHSMVLRAERVQQEWEQTYEQARQVNDSLNQQLADAWSTIGKLREELSVKEEVARQVHSRLVNGDARLVEAEGQLASAVNEMEKLREERGEWAAQLRQAETHAEDQENAVSSLQEEVRTLQEMLQVKEEELQASLQGNENLQVVLERFQENQRHDVESLTLESHLEAEELKKQLAAARRITNHHEKELAEVRRGFERQLAEKDAEVTTMHRKLAEVRKALEKTTSQYMDGSETCIDKRVVSQLLAKYMHAFIEQRKEAEDMLKVISGLLDWDEATQEFVGLLPGPNNPQPPDGFSSQRGGARRSLFRWLRSSADTSVAHSGGTPGTSKAGLASMWVEFLLKESEGSGGGGRSSRREGGTSAFPLTSTTPSSITGSQPNPSFNFPSPPAAAATETPEAATNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1Z0</accession>
    <name>A0A088S1Z0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Short chain 3-hydroxyacyl-CoA dehydrogenase, putative</fullName>
            <ecNumber evidence="14">1.1.1.35</ecNumber>
            <ecNumber evidence="14">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LPMP_351170</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.35" evidence="14"/>
    <dbReference type="EC" id="4.2.1.17" evidence="14"/>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703054.1">
        <property type="nucleotide sequence ID" value="XM_010704752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1Z0"/>
    <dbReference type="GeneID" id="22579146"/>
    <dbReference type="KEGG" id="lpan:LPMP_351170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350017300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_351170"/>
    <dbReference type="eggNOG" id="KOG2304">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000009">
        <property type="entry name" value="Fatty oxidation complex, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052242">
        <property type="entry name" value="Mito_3-hydroxyacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43561">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43561:SF3">
        <property type="entry name" value="HYDROXYACYL-COENZYME A DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="13">
        <location>
            <begin position="13"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="12">
        <location>
            <begin position="199"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="10">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIO02254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="305" mass="33471" checksum="CC86F7D8416285FA" modified="2014-11-26" version="1">MFRCTPSALFKSLAVWGGGTMGGGIAQVTAQAGVPVTVVEISNARLDVSRKMIEASLLRIANKKCDRDESKMKTFVDTVLSHITFTTSESVAAGNAELIIEAIVENIDAKKKLFARLDKLAPRSTVFCSNTSSLSITEMASVTTRTERFAGLHFFSPVPMMKLLEVVRTEEVKPEVIEQLTAFCKKVGKIPVIAKDTPGFIVNRLLVPYQMEACRLVERGVATFQDVDTAMKFGCGYPMGPFELSDSVGIDVIKFIVDGWHNMYPDEPLFKPSPLINERVAAGKLGKKTGEGYYKYDSKGHKINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2I4</accession>
    <name>A0A088S2I4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PHF5-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_352990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHF5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703236.1">
        <property type="nucleotide sequence ID" value="XM_010704934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2I4"/>
    <dbReference type="GeneID" id="22579328"/>
    <dbReference type="KEGG" id="lpan:LPMP_352990"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350037400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_352990"/>
    <dbReference type="eggNOG" id="KOG1705">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10248186at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005345">
        <property type="entry name" value="PHF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13120">
        <property type="entry name" value="PHD FINGER-LIKE DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03660">
        <property type="entry name" value="PHF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016468">
        <property type="entry name" value="PHF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="12708" checksum="80AD3A7F7106E00F" modified="2014-11-26" version="1">MLRHSKDLQMCRKTAGTALGYVCHLHEGRCVICDLQFSEIVDTMHEAHLCEDCSVLATEGEEACIMCGSRRVTDVAYYCHYCVALEKDRDGCPRVLNQTRQQRLAALRAAVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2S1</accession>
    <name>A0A088S2S1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_355220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703453.1">
        <property type="nucleotide sequence ID" value="XM_010705151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2S1"/>
    <dbReference type="GeneID" id="22579550"/>
    <dbReference type="KEGG" id="lpan:LPMP_355220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350060700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_355220"/>
    <dbReference type="eggNOG" id="ENOG502RYXA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="623"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="960"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="968"/>
            <end position="982"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="982" mass="107396" checksum="B1315BBB29F79A10" modified="2014-11-26" version="1">MQGDTPNSSNPYAGYQRGYTPQDGMQGYPPQAGRGGGAGYYQPQVQQPQVQQPQPVASQQPQQVTAQQYGGYNQPYAQLYAARGGYPQQQSQHQAPLQQGYAPRGDYYQGGNAYGGVGMQQGYPDTRTLINRGGYAQGYGQSYYPPQQQQGYYPTQQQQSYYNQGYNQNPNYAPAARGGFQGGALGVQQHQQPQQQPQQQPQQQPQQQPQQQSQQQPQHQPQQQAHLLNQQYGRGGRGGPGGFQRGGRGGGRGRGGRMFESYAVVHLDSYAQLEEVGRKGATETIVAPEVLSAMRSRGRGSTIRVLVIIQKQYAAACLSIPRGPEDTLLSEKTAETFMGVPCVIVGHAERLIDLANGAAIQGAVFSTFRSLMMLLTTFDKPKTTPAEGEQPVNVHEKTHDELLETVTKDIATYEALMTEMAADSDESTKLFSRLMQFAESEAHGQQQGEAHQEDDAAEEGHSESEEGDEHRTTVTDKPAESAASAKKLVKRTLMSSPQGIRILRTALAVNRKRQMFFEKIAPPPPNPEGNPLSRIEWSASLRLIDPLLHYPLLSDLVFSFFGVAPVGAEGVKPAKAKAQEVKVLCDAIARYGVQLTSSASCGNTILALLQAMDPQHAMVSVAERAAEESNRKPGLKRGREAGEGGANGDDSAQKAKAEEVSEEAKEVTSEVPELKQAPRSLSEYKAVTAPVDWRLYYAVAESWCTGEQPVLRRKRTRFVTQAQLDADAAAAEKPATIETRLRYVGHHLIGSFVLRYMIPIFADVVLSALKNPASRKKKDHDTFVQQCETILSTMAGAWSTMEASFTEGNIYRSLLMCLGSCAVPDTPIDRDLRTLLDRIVATIFDSSKEKYLSHCVQEALTVARQTKDGIRFTLQVARALMEKSDESLLNLAISPSGNYVVRHLCGQLTDYAMGKAAAESEVVTEAKEMEAKYYTFMTANLAKLSKIQYGRGLSSWQSEQTARLGATNAPTASSLPSSPNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2Y5</accession>
    <name>A0A088S2Y5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_354730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703404.1">
        <property type="nucleotide sequence ID" value="XM_010705102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2Y5"/>
    <dbReference type="GeneID" id="22579501"/>
    <dbReference type="KEGG" id="lpan:LPMP_354730"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350055500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_354730"/>
    <dbReference type="eggNOG" id="ENOG502S312">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272900at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="3">
        <location>
            <begin position="379"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="360"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO02604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="471" mass="50165" checksum="CCB4BE926EA7FF4C" modified="2014-11-26" version="1">MDISYQLWSLVEQTRCSSTRPPAKTHPASRKRTAVEDQATESLLTTSKALDDAAALAISHATAHISTVLAALDAVTPNSIAQLQNSLLLSDAELLSVSGSLKAFAETLTKVAALTATQRGRGRFKGTSSAAADSKDALESLAAEGLDAQNGSTQSGVVAHLRQAISTLEQRIAAKRLHVALAKEELALYKTELFFYGHCGVLFCSDQVASEVNRCMETTRKEAALWGKRGDDRAVYAESDGVSDDVGGKYRQQHTSSKFPTSKSGFGTTFRVVDGMMQRAAVTVKAAGSHADSALQVALTGGHAAARQLLHAGTASVAELLTFGVAARHGSRGDFSGPAAEAGLATVGGLALRPLTLQPFQLTKEEEARLQEQNRALLEAQREASAQDAKAVEASVRELSQLTSLMNEQVMQQTAQFSLLVRNTEAAHANVKKAVGEVAKPLSTFWNPTRQLVALLWVCMVLVLAVDWISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S370</accession>
    <name>A0A088S370_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Kinesin, putative</fullName>
            <ecNumber evidence="10">5.6.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_090150</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.3" evidence="10"/>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN95931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704253.1">
        <property type="nucleotide sequence ID" value="XM_010705951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S370"/>
    <dbReference type="GeneID" id="22572585"/>
    <dbReference type="KEGG" id="lpan:LPMP_090150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090006400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_090150"/>
    <dbReference type="eggNOG" id="KOG0244">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00106">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="48"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="193"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="817"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="502"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="633"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="911"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="998"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="193"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="845"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="122"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN95931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1099" mass="121321" checksum="595166A51366A9E6" modified="2014-11-26" version="1">MCRHASQPHTRNQETTHIDNVGKGPFNTCSARYTDLPHHLRDYSMGERITVALRVRPFLPHEDEPSCVVVSANQVSVGAGCLFAFDHVFDETASSDDVYVALGQPLADFFLSGFHASTIAYGQTGAGKTFTMEALLSDTVQEIFCRLTEDAETVQSSGDVSTTVSVTLSVLEVYNESIGDLLAAATSQLPRPQTASVVGGTVSQSVAVPAPRRSSGQALGTRQERKPSHRRASAPTTPYPSSSLALREDPHGGVYVAGLSEVQVHSEAELFTLIDGAIGNRKTASTLMNATSSRSHCVVTLTLQRRGLCSRCCFVDLAGSERLKKSLGLAGPSDRPGGLASPVEASLLPSSTVATRMREGININSGLLALGNVIVALCEKKPYVPYRSSKLTRLLQPMLGGNARTAIVACVSQLASSLEETLNTLKYADRAKRIPINPHLAIASVNTPVDAKQTIEVLREQLEDAQRRVVIAAAASAGPRNAAGSPEVGTLPSPSTALVREVEHLRDLLQTERRVTQRLENDVFNAEYTAMIEVEKRKALEARVAQLEATIADVLQANSERPIGASADSGTEHRAALVRSPRSGLTMNMVHCPQLKEKRDTVRLEAALVMDGDYNVDDLAATSTASADDDPFVVQLRKENVAKEDQITQLQENNDVSAQLAQYERELQRTLINQTHLRAELRKAEAKLEKSEMAREQKEQEKEKLRAAYEERLRRAETRTADYCRRVKEAAQQMRERQEDLDNTRQLREKVTELREEVYRQRLRARTAQKASWQLNAAHQQEVAQLQKQLQSSTSQLTLLHQRMDRKDTAIAKVRKQLAEQQVEPQPPQQRMHSPLSLHQPPEKTSSLTLSSSRATPPSPALGDTPPRIIKARKNPHMTSPPLHFHIGGPHRNINVKLKSSRDGDATQSTINLELQELERMEKELAELLEYRRILLTAQTTDASKWNSAKEGFIRRLSQVHAALQSSEPGQSEHTALLKEKHDVEEMLRQLQAFHHMFADAEQQLAEFDNRIENLNEARKFHTQRVRRLQCAVAKPRGDSGDMVAEKHQPSVRDIRTACANYTADGTSVSPAPVVSSRGKMEDMQVYATDSVVVGNASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3L1</accession>
    <name>A0A088S3L1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribosomal protein L1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_357120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703639.1">
        <property type="nucleotide sequence ID" value="XM_010705337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3L1"/>
    <dbReference type="GeneID" id="22579740"/>
    <dbReference type="KEGG" id="lpan:LPMP_357120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350080900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_357120"/>
    <dbReference type="eggNOG" id="ENOG502RVZN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251727at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO02839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="268" mass="29538" checksum="BE4A84E8F8A521A3" modified="2014-11-26" version="1">MSFLVRTEEAVKALVSFIASDAAVQTSSHDVADLFAPARESNSVPIDVQIAFLAAPPAHRVPLYFVVPHETVSGTLCLITPPPQRKYKDLVYGLSEDGDAVAKRVRRVVDSKKLAAKVGDPVAVRAFAKSYDHFIVYGLTKYPRQLTGEFLEHRKVPAWVNRKGKFAEKLRKAVHTVVVTRRGDNQVTCRVGHTGLSAQAIVENIVTFLDRFVKHADAAPLKNILHIRVAATSTNGKRVGLPIFGHVFQFQPVAESEEAPQKRSRVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3M6</accession>
    <name>A0A088S3M6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_356630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703591.1">
        <property type="nucleotide sequence ID" value="XM_010705289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3M6"/>
    <dbReference type="GeneID" id="22579691"/>
    <dbReference type="KEGG" id="lpan:LPMP_356630"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350075900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_356630"/>
    <dbReference type="eggNOG" id="ENOG502SIZP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267742at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="440" mass="47904" checksum="8BC40E398769D400" modified="2014-11-26" version="1">MQRCKCGVSSTTSGAATHHSLLEMFLRERLENWDREAAEAIVAWGRVGGMCSSEYQSQLRKAQATLRETHKEEKRREASVFQAGDGFRTDRYRRLRDRLATEFWTHTQVKLDATPQQRDRQLRTQAQPQANGQTPVSRSPTPQLTPPSCSRQLLRALKDSSTSASSQLTTARAHHMSPTPALRTSPPCSSRGASGGDVAQRGAPRAHKSEAEASNGVESERHTKPTVPLNEHDNVALPGAGSDGSSRLLLSAAGEREVSAAASTPAETPPKIDSFLSETFVVRRLSTHSHLSPSLVEFKHTVQRSHIMLDSSRPVAPPPPQPAHQIGHRWPAAASDVAREDSAGDKGSTPPSVSPGDPSLPHHSRAKPPESHRRRSARERCVNSSARTERSRGEPDADAQEGTPSALSHIISFKRGSHTDDLRSVSSAESYLDHGDHDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S4B3</accession>
    <name>A0A088S4B3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">14-3-3 protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_353280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 14-3-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703265.1">
        <property type="nucleotide sequence ID" value="XM_010704963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S4B3"/>
    <dbReference type="GeneID" id="22579357"/>
    <dbReference type="KEGG" id="lpan:LPMP_353280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350040600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_353280"/>
    <dbReference type="eggNOG" id="KOG0841">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10260625at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="CDD" id="cd08774">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.190.20:FF:000001">
        <property type="entry name" value="14-3-3 gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023409">
        <property type="entry name" value="14-3-3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000868">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00796">
        <property type="entry name" value="1433_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="3">
        <location>
            <begin position="30"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000868-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO02465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="258" mass="29690" checksum="0F924921A8D5D778" modified="2014-11-26" version="1">MTETIKWKNVTIQDEVVPKHTDIKLPDDPSELIYMAKLAEEAERFDEMLLCIRKYVRLNSELDTEERNLLSVAYKNVITPRRNAWRVITSIEGRENAKETSTTLPLVVNMRKELEAELSPLCDDLLSLLDTYLIPAAQGGEAKVFYLKMKGDYHRYYAEIDPGDGQRQAALNAYQKATDVANSSLAPTHPIRLGLALNFSVFFYEIMKEHEKGFQLARQAYDEAVTELETLDDEAYHESNTIVRLLRENLNLWTDDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S4H5</accession>
    <name>A0A088S4H5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_120530</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase F subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009381">
        <property type="protein sequence ID" value="AIN96381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697034.1">
        <property type="nucleotide sequence ID" value="XM_010698732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S4H5"/>
    <dbReference type="GeneID" id="22573059"/>
    <dbReference type="KEGG" id="lpan:LPMP_120530"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_120009900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_120530"/>
    <dbReference type="eggNOG" id="KOG3432">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261947at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10580:FF:000004">
        <property type="entry name" value="V-type proton ATPase subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10580">
        <property type="entry name" value="ATPase, V1 complex, subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008218">
        <property type="entry name" value="ATPase_V1-cplx_f_g_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005772">
        <property type="entry name" value="ATPase_V1-cplx_fsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036906">
        <property type="entry name" value="ATPase_V1_fsu_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01101">
        <property type="entry name" value="V_ATP_synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861:SF2">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01990">
        <property type="entry name" value="ATP-synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015945">
        <property type="entry name" value="ATPase_V1_F_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159468">
        <property type="entry name" value="AtpF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR015945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN96381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="137" mass="15260" checksum="6DD98EBC0ABF5050" modified="2014-11-26" version="1">MANSVRYRNGEQRIVGIIGDEDTVTGFLLAGVGDNRVMLNQGENPGEGQRRGFPANYYVVNPSTPLSEIEEAFTTMCARKDIGIIIICQHIANDIRHLVEEHNSVIPCILEIPSKGEKYDAEKDFVLEKITRALGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S550</accession>
    <name>A0A088S550_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein NSA2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_356570</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the pre-66S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
            <location evidence="1 6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703585.1">
        <property type="nucleotide sequence ID" value="XM_010705283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S550"/>
    <dbReference type="GeneID" id="22579685"/>
    <dbReference type="KEGG" id="lpan:LPMP_356570"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350075100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_356570"/>
    <dbReference type="eggNOG" id="KOG3163">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1847590at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11381">
        <property type="entry name" value="NSA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.310:FF:000001">
        <property type="entry name" value="NSA2, ribosome biogenesis homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039411">
        <property type="entry name" value="NSA2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12642">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NSA2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO02785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="260" mass="29808" checksum="2EE863A412E879EF" modified="2014-11-26" version="1">MPQNEYIEQAQKRYGRRLDHVERTRKREARKAHTDANYLKRVRGMKAKLAQKARYAEKAEIRKKIREHEEKQTTERVKDKGPKNALPSFLMDRSEADRAKVLSNSLKQKRKEKAGKWAVPIEKVKTVSEDEMLKAVTSGKRGKKSWKRLVNKVTFVGETFTRRMPKMERFIRPMALRFKKAHVTHPELKATFCLPIIAVKKNPQGRMYTGLGVITKGSVIEVNVSELGLVTPSGKVVWGKYAQVTNNPENDGCINAVLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S5J2</accession>
    <name>A0A088S5J2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Katanin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_150490</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697424.1">
        <property type="nucleotide sequence ID" value="XM_010699122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S5J2"/>
    <dbReference type="GeneID" id="22573469"/>
    <dbReference type="KEGG" id="lpan:LPMP_150490"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150010100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_150490"/>
    <dbReference type="eggNOG" id="KOG0740">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251136at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000022">
        <property type="entry name" value="Fidgetin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000093">
        <property type="entry name" value="Fidgetin-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF17">
        <property type="entry name" value="FIDGETIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="706"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="207"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="271"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="345"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="387"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="430"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="550"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="861"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="974"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="284"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="451"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="555"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="578"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="977"/>
            <end position="992"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN96771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1000" mass="106502" checksum="B8160A305F36D585" modified="2014-11-26" version="1">MFDTLRSIRRQADAMQGEAQEYSLSSAAAPHTTDKLGWVFPHLCHINRRQRALDSKVEEDRDIQGKRAGPGGDAGPPMRYQVAEVCMRYSQPLAATALAGSQRSGAGVTTLFSTSGVLCEASRDDAELSIVRDALPACTLWGSVLRLWCSSRGDCPKLRTLAAAQLQCLSPSDKPVAADDDDDTQRMAAALWAGAPDKLRQLLDAAGMGKNSDVSSEGRAGRHTKPSRTGLPAARNAPCQRRPRSPAEHHTDEVPQRARLDAAINIARGESGSATSPLVPPLPLQATPARAQAAASRPRSRTPSSRSRSQSPPPPPLPVAPADHFAAAARTRQSAFSFTVRIGESSGSTATVRGAVAPKSQQQQRSQQWVEGDVSDVVEMTESRAGIVGGTPRSHEGPPQSQQDLPIVSPSGPLRQKTFAAFISCSGLSTPQQYQQQQPPPPTSAAKRSPWLNQPPQQQLYSAAPSKAPPYEYDLRHSSRVNGVIEGGDERNSRAPTVTPSGEGYLALNSSSPSATVGSFVTAGEQLLADVRQGRAMCSAYLSKRSPALGLRRNTGFQPPYHQQQPKAPAGATDVHTALNSITAPSAAKTTGGTNRATGSASGAGGVRGTGSAATASHNHQGDGDDDSGGYPASLLLPDGSVPPILLPLDPKLVTQVAMEILEHGAGARQVGWDDIAGLQHAKASVEEAIVWPLRRPDLFVGLRDPPRGLLLFGPPGTGKTMIARAIANRAACTFLNISSSSLMSKWVGDGEKLVRCLFAVATVKQPSVIFIDEIDSLLSMRGEGEADSARRVKTEFLVQLDGVATDRGDRVLLIGATNRPDELDEAARRRMEKRLYIPLPDKAARRELIQRLFKSLAPSEADETGDARNAGEAASSSTTTVAARVTHTLTDADLDSLVCSTEGYSGADLKQLCREAAMGPLREVSVMQLSAVAAADLRPVQRKDFRQALKRLKPSVGPAEVQRYVEWNKLFGSFNEDNDDDDYDDDDDVGGDEGHDTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S702</accession>
    <name>A0A088S702_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_181510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697984.1">
        <property type="nucleotide sequence ID" value="XM_010699682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S702"/>
    <dbReference type="GeneID" id="22574041"/>
    <dbReference type="KEGG" id="lpan:LPMP_181510"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180018400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_181510"/>
    <dbReference type="eggNOG" id="ENOG502S1Y0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="444540at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="557" mass="62680" checksum="1BCD7DB4EBE24F35" modified="2014-11-26" version="1">MFSVDSTHESALTDPLFMLRLYKRVAYGLVPRLHSDGTRAFLPSFLSVDSRYVESTNVAVDAAALLIAVEPIFPTSLLTHKEVSLLLRVLELEEEETAKEASPTDSFEEAQRGRRRSCARGIRPGRVTLALRDIIPFRTWQVSQTVAAVRRAVQESAVMSPFEEHLVDVLDWQNSRRRQATEESPPPLERWEALAFMEDTCGLSSSESHWLLHYCASEKDDDAEDGTATGSCLGCEVVLLHQLLFSKVIPSVAEYPLLMGRFAEATLDIGETEIYHTGTLALQSVLESMELHYPEHSRQLPLDLDIRALVRAELTSRQFFYVCTKLRTGFRPEESNQLYYYLKKDSETEDGVLVADLLAAYRQYFPSITGSMLQLVQAAVVEWMRRSAKNGPAFVQLYSALREWGTERVPIEAFIKALRAAGVPDGLSGVLDVELEWLRLKSPTRVDLVLMLCTPVPPSRVAVIRKLFNRLDRQHSGNVACAALLRSFHPELIEGNAVRQQGTIWKQALEAYIVELGGGELDYEVFAYFWYMVSASVEDDPTFTMVVWQAFGLSDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S835</accession>
    <name>A0A088S835_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DDB1- and CUL4-associated factor 12 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_202400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97736.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698443.1">
        <property type="nucleotide sequence ID" value="XM_010700141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S835"/>
    <dbReference type="GeneID" id="22574449"/>
    <dbReference type="KEGG" id="lpan:LPMP_202400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200029300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_202400"/>
    <dbReference type="eggNOG" id="KOG0282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6262491at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056151">
        <property type="entry name" value="Beta-prop_DCAF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23760">
        <property type="entry name" value="Beta-prop_DCAF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN97736.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="541" mass="58214" checksum="712690C43779B708" modified="2026-01-28" version="2">MADHSASSAALQGAASAAQHQRIHLQRQLTEVRMENTILRQQLYQVSTLLDIAVSKLGAMGVSLETPIDIRALRTEALQRAHAETTKADYDAVGASPENGKSPAQHHHKKFQMRQQLREHTRAVQCCAFSDSEDLLIATGGMDCRLIVQNYLSGANLWDATAHEEAVSDVAWMNHNCLLSASYDNTVRLWDVNGGTTNKDVLYQYTAHGFVLSAILLGPSLFACADSRHKTAIVDVRAGGKGVVQEHDYRINSLSYDDASQQLLMGQSNGVVSIWDMRRPDQAMCTANSNTGGGLPASPSPLLLQQQQRPGSLSDANDPVEGDTTPTTAIEDGAAGDSSALGSNGGLMASGSTTSIGSPPRFARATEIENEPSRSPISFIAHFHSDDDTCRLVCVSGDNMVRLYRGNFSAFTGGGRKEGASLYVLRNVLAGVPTRGNVMRSGFWKGDRGKPEMSVFFDDGETEGVARPPRRLTECDLLVTGGPGNTAQVCDVTDDGSAVVLERLEGHRDRVTGAAVRRSRKPIIATMSADSTVRIWMPVTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S8G8</accession>
    <name>A0A088S8G8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Coatomer subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LPMP_204070</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698608.1">
        <property type="nucleotide sequence ID" value="XM_010700306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S8G8"/>
    <dbReference type="GeneID" id="22574618"/>
    <dbReference type="KEGG" id="lpan:LPMP_204070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200046800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_204070"/>
    <dbReference type="eggNOG" id="KOG0292">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261470at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22948">
        <property type="entry name" value="Coatomer_WDAD_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000002">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047312">
        <property type="entry name" value="Coatomer_alpha_WD-assoc_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016391">
        <property type="entry name" value="Coatomer_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010714">
        <property type="entry name" value="Coatomer_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF1">
        <property type="entry name" value="COATOMER SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06957">
        <property type="entry name" value="COPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003354">
        <property type="entry name" value="Coatomer_alpha_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 12" id="KW-0813">Transport</keyword>
    <keyword evidence="4 13" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="5"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="47"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="89"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="131"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="192"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="236"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="15">
        <location>
            <begin position="331"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="17">
        <location>
            <begin position="610"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer alpha subunit C-terminal" evidence="16">
        <location>
            <begin position="816"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="824"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="824"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR003354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF06957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AIN97901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1196" mass="132423" checksum="384119CA556AF55A" modified="2014-11-26" version="1">MLTKFEARSSRVKAVALHNSATWVLCGLHNGAVQIWDYRMSICVDTYTEHVGAVRGADFHVNQPLFVTGGDDYTVKVWNYKLHRCLFTMTGHMDYVRTTFFHHEQPWILSCSDDFTIRVWNWQSRKSIACLPGHNHYVMCAQFHPFSDLVVSGSLDKTIRVWDISALRHRKEEMGITQDLLGTTDVVVRYELEGHEKGINWVAFHPCGDLLLSAADDRTVRLWTMSGTSCYVSRTFTGHTSNVCCAVFYRNDYLVSCAEDRTIRVVHMSSGATVQTFRREVERYWIMASDSVHNLIAIGHDTGLQVFKLTRERPAFAIHNATELYYACQNKLNMYNFETEEVTSCTVNYQFYPPTALSCCPTTGGVMLSYAKGGPQVEWIPKPLATRTCNVEGTMKGIDGVFFGGYKLAYVDVNGKMCIQNVSKPGGKPQQTDVLCSRIFAAPVGCVLCQSDDKILLYQVAQHGAVMEATVPAVRYAVWDKDFSKVALIAKNTVTIMTKRLKLIASVAESSARIKSAAFDETRDVMYFTTSNHLKYCYLRNGETSTISTLKNVVYLARAVGDTIYVLTRDGRVLRKELDNVELNFKLKLQQQSYRDLLRIIQQGKLKGQALVGYLRKHGHSEVALHFVSDPLTRFNLAIECGAIDIAKAMATELNQPVTWRHLADTATRFGDIQLAQFASAKAGNYYASGLLALLTGNTASVANLVNATHDDHFKLHYGMYVNDAKGRVDLLCKANQLPLAYVTAKSHGLENTAAQLLQQLQPDVAARVEAQRFYPVPQQQPVDPVTENWPMLQVEESVFTRLLKEPGHLDAIAQPELDEDVAAGAGWDDDEDDGALLAGAGADDGDAGAPTYNGDKRGGWDDDLDIDVSAALPDAGGACAASSGYVVPREYPPITQTWTDAYTLPAFHVAAGSFASALCLLQRQIGLADPTPLKPYMMQLWAAVNSCRPAPNGLSTVFALSTQPPNSETEAPHAPALPDFMPVLAEKLRIGYQLFVEGNFAEALDVFRSILHLSVMTVVKDDQQKATLREIMAVAPEYTRALTLQLQLRTLSASSVEALQLALYFTHFRLHRAHLTLALSQAMSKAYKQKNIKTAAEVARRLLEQDPPKNKAQQAAAIIAEADRNPTNAVPIDYDERNPFIMCSASYKPMYKGVVSPVRCSYCLSPADPSYRGTLCPVCKLSKIGVDCAGLVNRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S999</accession>
    <name>A0A088S999_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_211170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698903.1">
        <property type="nucleotide sequence ID" value="XM_010700601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S999"/>
    <dbReference type="GeneID" id="22574939"/>
    <dbReference type="KEGG" id="lpan:LPMP_211170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210015900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_211170"/>
    <dbReference type="eggNOG" id="ENOG502R4CE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5560686at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="536"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="714" mass="77674" checksum="090571ED946B33A9" modified="2014-11-26" version="1">MPLHPHPLLRATPLPLLHRRLERGPCSGSRSLWILWWLPLQRRCEAHVRVQRRAFATCSMPRSWSSLAPPSSSPSLLSATVQATGVVTRLGPSERLPGLRGVFLTEPMKKFHPIEVLPTAASAAASTTTAATVGGSAEQSNVPRNPASEFSTQAPPLVLNLAFAPRHSISLRRFLALRHMFSTSAYLHVATEDGWYLVAPSSAAPLCDDVPGLQAWCCRHHHRYLKHPAPFSRASTSSSGLSSRVAHPRRRTEIDKLEAALDNGEELSEKQLQRLAAQEKASFAQRPEHEGEDEEDDNPAVDEPRHQASREGVAPAEEILGERTDGAPALAFGLPPPPLRTSPPLITEAHLFDINDGVAWPLPPSDDLANHEYWKGHRQRMALYESTGDTDAAVQREALLAALRADLEITQRLLSEQELYAAAEELFQTLKHKANVTLNVDAETGLLTLVPLRDLRAGEELLLHYGREWWTGRLLFSLLLSVSDAAMPQIRWIEQLFESAVDANEPFPLLISAHEQRKRLRRGGAGSKTARRGLKSKSGSDGGKSQQQPTSSAALAQPHHSCVATSSTTTTTAGPLVSQPKSGRVVLYNTVTRKRATDAAVLAFAVRRSCTDLNFWNRLLLGDVASGLEPVFHLSEPDSEVPMRVLRHALLASLRGVTAVTQSSVSCEDRGAPIVARSAVTNTTAGAAEQNVPPHMTAGACGDGDDDDDVVFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SA94</accession>
    <name>A0A088SA94_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Orthologous HASP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">OHL</name>
        <name evidence="2" type="ORF">LPMP_231160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699273.1">
        <property type="nucleotide sequence ID" value="XM_010700971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SA94"/>
    <dbReference type="GeneID" id="22575321"/>
    <dbReference type="KEGG" id="lpan:LPMP_231160"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_231160"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="199" mass="20056" checksum="C3B5A48D24D8E8D5" modified="2014-11-26" version="1">MPRGTNRPTNQKGRGKGNKKKGGDHHGHGKRDGGDHGHRKKDGGDHKDEKVNGGDHGDGNMDAGDHGHGNMDGGDHGHGNMDAGDHGHGNMDGGDHGHGNMDAGDHGHGNMDGGDHGHGNMDGGDHGHGNMDGGDHGHGNMDAGDHGHGNMDGGDHGHGNMDAGDHGHGNMDGGDHGHGNMGDGDHGHENMDGGAPNGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SEX5</accession>
    <name>A0A088SEX5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoside triphosphate hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_301270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701157.1">
        <property type="nucleotide sequence ID" value="XM_010702855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SEX5"/>
    <dbReference type="GeneID" id="22577181"/>
    <dbReference type="KEGG" id="lpan:LPMP_301270"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300017700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_301270"/>
    <dbReference type="eggNOG" id="ENOG502QVQD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070300">
        <property type="term" value="F:phosphatidic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038727">
        <property type="entry name" value="NadR/Ttd14_AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053227">
        <property type="entry name" value="TRPL-trafficking_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34932">
        <property type="entry name" value="TRPL TRANSLOCATION DEFECT PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34932:SF1">
        <property type="entry name" value="TRPL TRANSLOCATION DEFECT PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13521">
        <property type="entry name" value="AAA_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NadR/Ttd14 AAA" evidence="2">
        <location>
            <begin position="315"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="768"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="864"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="573"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="793"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="915"/>
            <end position="924"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="945" mass="100704" checksum="C35AC0B1178F0FB7" modified="2014-11-26" version="1">MGVGVFTMRPTGSAGIGPKSNATRSAVLPLSSEERVEALSVTTPPPAAANTSVTAPAPPTTQNTSNPRKLLTDTQAARAVLVPAAVPAPLAAPQPHRRFPPYPRETSTLATPPPAEILSAPPAVAETAVKRLRKEGCVTEAPHSAQAVLFARAEEGHHYAAGGAIAGVNCLCRRSSHGTAVATNFKMKNGEDAKFNVKTSDEGRRGGAPLRSEGGFYSEEEMGQCAASAELSPSPEAPEAEEVTAAASASVEATDLADAPALLPPTGAPSQLRSTFIAYRPVARSVSPGPGLGQYKGLPLTAVQEVLELKHKVYRICLTGGPCAGKSTMLSAIQAKIPQRTGFRVMCVPEAATLLVSGGMQWDGSLTVPQQLGLLRTQLALEDQFYALAVASNVPTIIVSDRGTMDGRAFCTDAEFQEILHGVGSTMDALRDRYDAVIHMVTAADGAEEFYNLDNPARYEDLDGARTSDVRLREMYVGHPMFRLLDNSTTFEDKIERGLQVVAQVVHKEQCAPALPTYYVVRRCPTELPVACATYTTYTTVLGNSQMSDIRLLVKREMADGSTMHFFKSVRESPSSGSAALSSRVPPRQTSRTSTGASFRSSLSIPMGSTATPMQRRIESAQRISSREYASLCKHRDYTRTEVVMKATHFIFEGANYELTTLVAPSWAAGRQTLTVESCTVPTAQQQQQQQEHRHGSRHAAPLTPALRLPPFLEVDREVPVESLTTAFLISHKETGPLYTSLAFAPVFSRAVVTALGAHADTENILSSTLSTPRGTPALRAEMDTLPTSPVAAEKREEERISTKTAPSREGGRRVEDMESSVPAAEPPPLPAPARRGLALLDANTLSISASAIKSTTTKLVGASNVKGQPLTPRRDESTSIDMGHNSATPTSPCLAVEEEDVAETTTAAPAGERPQPEKLMARDPKCILPPIKSKKVPTAACVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SF35</accession>
    <name>A0A088SF35_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BILBO1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_301920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701217.1">
        <property type="nucleotide sequence ID" value="XM_010702915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SF35"/>
    <dbReference type="GeneID" id="22577245"/>
    <dbReference type="KEGG" id="lpan:LPMP_301920"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300023500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_301920"/>
    <dbReference type="eggNOG" id="ENOG502SE9W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="240624at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040747">
        <property type="entry name" value="BILBO1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18281">
        <property type="entry name" value="BILBO1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BILBO1 N-terminal" evidence="2">
        <location>
            <begin position="14"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="410" mass="45830" checksum="D604B92C0570F420" modified="2014-11-26" version="1">MEFPVFVASDVHGEKVNLALRYNPWTDTLDHLLTAASHCFAGVAHLMCQGPLPPFSAAYIYQDVQFQWDALQDRTQLSPCCQVYVFREAFDETVAGIPDPLDSSRLLLMLTGKHASMPSLTDTSVVSQPSPLNLSASNLSIRLASNRWALPQYGQQPGTSRLRFDVSSPLCKNRVPLVRMQSPTGSDKATRTDDNADDFHKLWCTDETVVFRPVQSHRFRLQIFSPTMETEMRHGDTRGSAEKPLICSGDFRASGPQTAHVKPKRRHSSDSYKGLSAESSYTGEVAIPRSWCDPSRHFFRSTASHVCESDSSFPQSFSVSSYSRGTAQPFPSGSVRSKGLPRIDECHPEVLVKREPRSGGGGSILRDERERIAAQMQMGIDELRLRLQEESRDLKRTLSGSRHRVVFPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SGN4</accession>
    <name>A0A088SGN4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_320850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO00972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701772.1">
        <property type="nucleotide sequence ID" value="XM_010703470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SGN4"/>
    <dbReference type="GeneID" id="22577826"/>
    <dbReference type="KEGG" id="lpan:LPMP_320850"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320013500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_320850"/>
    <dbReference type="eggNOG" id="ENOG502RYKQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268520at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="1">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="165" mass="17708" checksum="B34079EAC029E72D" modified="2014-11-26" version="1">MGLDILEIDPATPHPGVTIDGTTAQRETNGGWVTLRSKTPLSTTNHQWAIRILDQGEGADGSGLMIGLLPQLSAQMASATGGKYISELGGWCISRAGDTYGAWKCDRFPYSTDCVVEFDWDAATGTVYMVSGNKKGTGHIPGLKESDVLYPAVSMYYLNQKVAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SGN9</accession>
    <name>A0A088SGN9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_320900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO00977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701777.1">
        <property type="nucleotide sequence ID" value="XM_010703475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SGN9"/>
    <dbReference type="GeneID" id="22577831"/>
    <dbReference type="KEGG" id="lpan:LPMP_320900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320014000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_320900"/>
    <dbReference type="eggNOG" id="ENOG502R2R7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271983at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021790">
        <property type="entry name" value="PTBP1-like_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11835">
        <property type="entry name" value="RRM_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PTBP1-like RNA recognition motif 2" evidence="2">
        <location>
            <begin position="23"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="512" mass="56169" checksum="E5378198BE919BFA" modified="2014-11-26" version="1">MRGRGGRGGRGGSFGGFTQQPTNTISIRVSEIQQPVTEDVMRRVFQSVGVSCNSIQITPTNNPQETSVVAHFPDNFAAERVMSSLNNRNIFNNGNKMSMQYTTWLTSGSPAPMNSNNGGVLQSSAFENGNAFAAQQMPQLPQMPQMPQHPQMPQMPQVPQVPQVPQMPQVPHHSQMPQVPQVPQQPQISMPTQPIPQPQPMPMSVFTNPVSGMMQPQQMDAWYGANPAMDMMSVTVGFPGAARGTAMMRGNRARGRGGRGGYGFDPMALQPGYMPFAQRGGMIRGGPAMMPRMNYVQYQPFGQPPTVFVSVTLVPVTEPLQPIFTLMESFGGVTAIRRNQNKKEILTVKAASPDDALAIVTYMHRVPYVGGQVSGKLFPNYVERYPCTDEGDPLDPETVQYDFTASRHRSPGHRSKAVPSRIIKITGCNTYEDTEVMTYLNGKGINPERITKSEDGTFEVHLPDVATSVKVLLECQGSVCDEEKSNVIFVEGPRDDPVSTDHKVAEEHANEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SH87</accession>
    <name>A0A088SH87_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclic nucleotide- binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_322670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701952.1">
        <property type="nucleotide sequence ID" value="XM_010703650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SH87"/>
    <dbReference type="GeneID" id="22578008"/>
    <dbReference type="KEGG" id="lpan:LPMP_322670"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320032900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_322670"/>
    <dbReference type="eggNOG" id="ENOG502QUC2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273135at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050397">
        <property type="entry name" value="Env_Response_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24567">
        <property type="entry name" value="CRP FAMILY TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24567:SF26">
        <property type="entry name" value="REGULATORY PROTEIN YEIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="672"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="913"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="915"/>
            <end position="928"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="958" mass="102697" checksum="C927452DA8740DF9" modified="2014-11-26" version="1">MSVSDLVPKLPSGQQMVENGLPTAVQEQLRAIALQVLQRLFVPILRRHHLRKARLALTHELLSSHVSLQEVEAAAFSALQYTSYLGAVTRDFYTRADGSRFSTLGGTAEAEAAAVVVPSLDAATGAAIRDTVRDILNSSYVQLSVHLQDEILEWEWEPASEVLVLVGGSLERRGTAVALKATASAGGLPNISPGVSVLCSRRASAMAGYGFSRRDSATTGGASQLGTARRASATMHLSTSSHGGSVGGSFAVRPTSAFLRRSLTDFGQDHAACASAIGGTAGAPTTPNSAVLRAPPSAPAPADAGVEFLTAPQVLGELACIGNFPYCAALCVSSPTAVILRMPKVIYCYMVSECASSAGQQRLLVEAMQMRERLLPYFAPLTRARLQICPLLTRLRTEYLEHIRDLMIPRVYAAGMECGEKEQPTHIFFIRRGVVQMQREASVPGNDSGAPSRNNSEPASPIAATPAATPYTNFSLEFPRNRSVLVEGHTYGETSCILADTVGDRYTAVTHVDMYLLPFQVLIQLMKQEPEVHSAIYYSAQEFSYLRDKEWAGVLFGPRLVGAKLSGVHGVVPAEGMLALMATATHERASGGGPRDYRGKALAESPFSVDHLSHGSARRGGGGGGHRSSASARRVTIFEEALNSGSTGDRAGSGVGGANVLPLTGGRVSSALLNAMEEMPLVSLLPSATRDFYRACTQQWHCVPYKKGDVIVTSGAECNRLLLFFEGRAGIVMNAPLLHDEMRSGPFGRADIASASPAAVCPIPPGHVVGYTCVRRHRWTRSIIALDNVVEVWEMHRNAFVQLLRTHGLERGMQAATLQVLQPLAPQERLAVLDYQPLLHPMPSSLWREQAVPNVHPVVVTNESAVCFPVWREGDFPLDRHQSVMDTTARAGSAGARRATLLSASSMKVASVANERQRSASRLEDSTHLRSRHSGSTAGMAEVESTSRHHFIAQLAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SKG7</accession>
    <name>A0A088SKG7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Calcium-dependent phosphotriesterase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_351800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703117.1">
        <property type="nucleotide sequence ID" value="XM_010704815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SKG7"/>
    <dbReference type="GeneID" id="22579209"/>
    <dbReference type="KEGG" id="lpan:LPMP_351800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350024000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_351800"/>
    <dbReference type="eggNOG" id="ENOG502QSZ8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270901at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839462" evidence="2">
        <location>
            <begin position="27"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="467"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO02317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="542" mass="59691" checksum="3285BC9E85FE1F2B" modified="2014-11-26" version="1">MPRRSLVTLAAALLLVIFACSHSGRALCPSNGNTHAIYVTSNMGNNIWSFDTLGNYLGPVLNKASFPPGVQVDKLRSMRFGPEGHLYVSSARGSYSRIFAVSGNGLLNRTMEENCTRDYLFTATEQGQANPFLDHPYDIAFHPATEDLYVSNQNSVTITWYKRDPMADTMLTVGTDRSQQVRYPAWKPAKNAKAAVVSNEETMTGEETIVVPKDITDSSGLFASPWSSTYSMSSVRGLTISPLLPRTLVEGGASSGVFAVTNESMMYYLLVCDVLSSTVHVFDLESGERLFGLNVPSPIQVMFPSRYYVGDSSPSVSADGVLMKRFDVPYIYVTSKEDGVAYMVRFSSRQGNTISNGMQGNGFGEGFIQAQRLYMINRPISLHAASGIYENAARNVLLIADRNGRRIYTYASPLLTDYTNGYGPSTFLGFFVKHLPDQPEFILSALLEHQENIPFCYELNKDGKLRYVALCTAASIWSTVLALALILVSSFIVYRQVQHCMYEQKGYFQHQRSLDDESIVLNGSSNSSPLLGGAVPNYGSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SL02</accession>
    <name>A0A088SL02_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_353500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS26 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703287.1">
        <property type="nucleotide sequence ID" value="XM_010704985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SL02"/>
    <dbReference type="GeneID" id="22579379"/>
    <dbReference type="KEGG" id="lpan:LPMP_353500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350042900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_353500"/>
    <dbReference type="eggNOG" id="KOG3063">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3821113at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028934">
        <property type="entry name" value="Vps26-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12233">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 26 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03643">
        <property type="entry name" value="Vps26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="361" mass="41390" checksum="9349B5E617B4F9C2" modified="2014-11-26" version="1">MLRDEPPPEKGQQSLSLFSRLLSSIDGCKLEVVLDGKAEEDKIKVVDIYDNVSERFPLYSWKEPVKGRVMLMPTSSSYSHQGVVVELIGVASTFRDVESRVVFLRQERQFEPDTLTQPTPFEFVFSAPKEHESYHGIYAKVRYFVQATVRQRIKSPSVKEEVWVHRVDAALSESQPDASAHVNYFRETYFGPESISMNVGVENVLHIEFRYDKKIFHLAERVLGKVEYKIADMDIAYGEVGLVRKEFIAPGQSGETMESETLQKFEIMDGTPIVEEVVPIRLYLNSIPRLTPTYMNVENLFSVRYFLNLVLVSQEGKRYFKQQEIQLYRRTGQDRPVNSLGLGLSAKPAQRRMNTKGGWSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SLN4</accession>
    <name>A0A088SLN4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_355870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703517.1">
        <property type="nucleotide sequence ID" value="XM_010705215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SLN4"/>
    <dbReference type="GeneID" id="22579615"/>
    <dbReference type="KEGG" id="lpan:LPMP_355870"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350067200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_355870"/>
    <dbReference type="eggNOG" id="ENOG502QRH2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="242049at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="669" mass="74504" checksum="DA24CA54356CEDD3" modified="2014-11-26" version="1">MYAVSLAGLCAELSRIQVDLLQRRGAPLLLAHEGVQLLREQLPAIELPSSVNPQISMLVPKLLRSCAAVLRFVPYEDVLPALDALEFCATLTAKYNDGGHIGSSINLNDLCSLLRSISSLDECQARLLELTKLPSHLNVGASRASESPTATTAPVPVRRFETFFLSVYHHAMQLWSLGRERPTTLSVLSLLEATSRVYGKGFHFPSVGADKSSLLPAKAKIRMEAKIQRCVGARGLLTSLRELELNRTDAGMCLATMAQTGLYDAEVCNRSCDVLFSQHAILSSQQLCQVMFHLGTLQHRHVHQKFFSSLIEPERCNAEAVRQHVLGLAMLRQPPPSEVRLMNGVFLHALRTPHARQRQQRNCEGSSSCTPSAQSERRDGQTRHLLSSRARRAIADPLNDNEYILPPQWYIDVGHSLTCLGIQHPKYKLMTARQTRRSIGRLTTAERCKLLYALGGMTVEEVPLELRQTWHAKVKRSIDIAAEQLKDIEPHEGPYVMNALLYCGIQNHPRIPRAPQLESDKNPVEVLLRTWATVPKERALELTEQIKLQHLRTTAWKAPSALAEVATRVAATLDGASPEEPHQLEPLCAAVETHSAVMSAEDLLRTLKALLQIGYTGPSQHDAIRQLLAHLWGRRYDLEGEQLIQCCECVQQCSDLPEAMRLLHFAASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4W2</accession>
    <name>A0AC62A4W2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RNA-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3420490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="XUY36813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="221" mass="24353" checksum="42B45B5CE1571FC0" modified="2026-01-28" version="1">MSSDGAAAASSVADGETKAPAAKTAAASFVRETRNIKIPHHRFPPLKKVWMEVYTPIVEQCRLEIRMNLKTRSVDLRTSPSTSPAEGDQSVAASKVMLQKAEDFVKSVIAGFDVRDAVALLRMDDVYIEGFEIKDVRANLQGDNLSRCIGRISGSHGKTKYTIENVTRTRIVVADTKIWIMGTTQNIRVARDAICDLIRGSPAAKVYTRIRAVMNRVNNAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A508</accession>
    <name>A0AC62A508_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">6-phosphogluconate dehydrogenase-like, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_340270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="XUY36763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1375" mass="141334" checksum="0A98C35D609B00D7" modified="2026-01-28" version="1">MRRLQQQLGHCAWTAGLLSNTSRHVNLSAIGVDVVTLPSPPSEPPSVPLVSVATTFSDVLKAAPAAPAAPKVVPAAPKVVPAAPAAPVAPKAAPAAPKVVPAAPKVVPAAPAAPVAPKAAPAAPKVVPAAPAAPVAPKAAPAAPAAPKVVPAAPAAPVAPKAAPAAPAAPKVVPAAPAAPVAPKAAPAAPKVVPAAPAAPVAPKAAPAAPKVVPAAPAAPVAPKAAPAAPKVVPAAPAAPVAPKAAPAAPKVVPAAPKVVPAAPAAPVAPKAAPAAPAAPKVVPAAPAAPVAPKAAPAAPKVVPAAPAAPVAPKAVPAAPAAPKAVPAAPKVVPAAPAAPNVSRWTRWQRRPVAGASNTLENQRSSSRGAHPQPTERQQADAKHVVACVSSVQQFPHRTASERPAAPPPPSSPPPAPSLSTAPLAPPTPPSTSSAHTTIAPPSVSAVAEADSEATDEKLFEALQPSLSTRIEAAVRQGKAACLLTASHTAQQPQVEQLEQRILRTDTEAHADSSELIEGGATGDWACAKREEWLLPLPGFISSSIDRHEIPAELGGDDGSNVAECTTARSTANDFSRKATTTAPADAAPLLSALAPELSESATMERLPIDVWFGADAASCGKGATAPQRPRVTDNSDVCLVVSTSVTPQKYAITVQLREPPSSPMACVQAVAGALDTVEAHCNTAVTSHTAASVDSALRVAPAITVTWCALPHCSFFAATQSPTELPLSQRVDYVTAKETVMERFNCLVARFRARVHFAAVVSSGSVLDFGAEVFFACVERRLLSLQAAVCDGSDEAAAPVGSSLPSVSTISVGFPLSRVGIFPSTSTVVSMRRLCGLLHTVKWIPVLHTYDASSLADVGLLSLSDATADASDKSRTKQWSLLLEQLIIERVCQSPVQRRWAIEMLLWSRSFHDAAVRHKAAGAMSADIADAWHKYAIGALSRNPLSTELDTARGDAGSVTRVHLLLTTPPCKGAAHALQVHARSLRRSLPPLPHHRFLAFPRVQYSLWMDKVQTLTAEKSVGAVVLLDCSEKAVTDTLNLVKTHLVGTAAQRARLPYLNVVLIGEAAATQRMLQHLPCAAVITSASAFCEMGHASVQQVRLYVSPNWPADLQQDTLLAALTYLKRRGVPHVVAASAAPQRLLLALCNEAVLIARSLPDATAVESAAKEQLGLCLGPFQLMDAYGTVTVATMAADERTRTAAASDAGARAAVTPAHPLESCMRSMAREGLLGARGARGGFYGPAVAMNRGGAAAPLLREAVLSTYVRHHMTPIQVGNRLRAAVLNVACELLTRGEVQLVDDVDLLSMSALGWREETGGVLYQVDQLGADALPRLVEHMTCLASTGSAPHLAPHPLLLRMVAEKVRFANLHDSGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A522</accession>
    <name>A0AC62A522_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NADH-dependent fumarate reductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3420160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="XUY36778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="543" mass="57545" checksum="4BC5586EA8412D02" modified="2026-01-28" version="1">MVSGTHAARLVLKKGHAKPAAPGRGRPRFPGRWRGMMATARGAQRLASDEAGVPHAKPRVLRHAGRFLLRGAPGECAARSRKNGSAWGTAVQKAAGVHDSGELFEKDTFASGKGGSCQPELVRTLSDHSAEAIEWLSSFGIPLTALTQLGGASRKRCHRAPDNPDGTPLPIGFTIVRALENYIRTNLSDIVRIETNARLISLMHSKEDDAVVVQGITYATQTASGEGKIRKLQARAVILATGGFSNDHTANSLLQQYAPQLSSFPTTNGVWATGDGVKAARELGVKLVDMDKVQLHPTGLLDPKDPSNRTKYLGPEALRGSGGVLLNKNGERFVNELDLRSVVSQAIIEQNNVYPGSGGSKFAYCVLNEAAAKLFGKNFLGFYWHRLGLFEKVEDVAGLAKLIGCPEENVTATLKEYKELSSKKLHACPLTNKNVFPCTLGTEGPYYVAFVTPSIHYTMGGCLISPSAEMQTIDDTGVTPVRRPILGLFGAGEVTGGVHGGNRLGGNSLLECVVFGRIAGARAAAILQEGGAGLPLQGGGQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A574</accession>
    <name>A0AC62A574_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribonucleoprotein p18, mitochondrial, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1520030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="XUY37007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="187" mass="21333" checksum="9940DD9EF80F44EE" modified="2026-01-28" version="1">MRRLSSQLICTAAAARFASAGGAKKYDLFGYEVDTNTAPWIEKVKKCQYYDEAGEVLVSMNVKNCPPDLETYNATLQKIFEAPSKQDKPVDNESKFCAMMDLMEEMQHRNKVKPNEESWTWVMKECVKSGQFRLGYCIARLMESEFKRTPEDLVKQNEANAMKAKADGKEHPSALAQQQSLFEIKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A592</accession>
    <name>A0AC62A592_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ESAG-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3420370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="XUY36801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="648" mass="73469" checksum="B07D3C3D2FFE65A0" modified="2026-01-28" version="1">MAQTFHRGVAHSHRWRLSRSWRRCAGLFNRRAVPLVSAFAVVLLVTAAVLLTLRRYAWVPDGSDLVIPYRSEAAVYRQNAAFVAPFPRGGGIGVANTSTETVPAAVHSRSCRQEALEAEIETYLASHGIRRERRTRVRFQIVSNVVDWRLCTTLGSAALAGFSIPVTGFNAAYSHIRRFESYLKFVEREELHDEDIVVTMDSDVYWTGADFLPFLGKFARFSPEQESDLDVAAVRAWEDYGEKKAPLYMQRLQAEMYNDTAGLKRPLLQMPPVVYSAENVCWWGQHSEGFVQCPLAYATLDHMVEVARNHASTIDVHKAASYAGVSAKTLRSELKKSFTGKQQWMVDDMLGTPNAASPYTTQAKRSRDDPLFYNVTVVSKSNPTVLLNGGMYVSRVWALRRLSKALATYMATETPVAEGEDHHTSKWWCDQGVLGQMYVRGRLYEVEHNLLAGPPLSRRTPPVPYDDRYGPPGLIGLDRRSEMAVVALSMLYSKTLFHPSKYLEEQSLGSNRWWIWNKAELLLGKNEPQGHSLKHLQTTRGGALVTPPLLWRSATAEDRSRGFQNEAEEDPDVVRIPFIHYAGPSKHKLFTTHRHYYSWMVAARHDSRARESVTNALRKELVELWFNEERVFVNFTLMCKDPTLLSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A620</accession>
    <name>A0AC62A620_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATG8/AUT7/APG8/PAZ2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ATG8B.2</name>
        <name evidence="1" type="ORF">LPMP_1920170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="XUY37138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="118" mass="12274" checksum="A4EBC961EE5BB0EB" modified="2026-01-28" version="1">MSAYQSSNTAEARRAECARLQAKYPGHVAMVVEAAKSSKAHLLALPRDATVAELEAAVRQALGISAAKVTLAVEGCTPAATAAVGDVADACKHADGFLYVSVRGEQAMGIFSLCFPFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A657</accession>
    <name>A0AC62A657_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATG8/AUT7/APG8/PAZ2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0920050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="XUY37322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="124" mass="12846" checksum="4224028B6550883B" modified="2026-01-28" version="1">MSAYVSSTPLEARVARCASLRATNAVPVVVEEAQARGGKAHFSALPRETTAAQLVAAVRAFRGVAANKPVTLTVAGCSVSPSATLGELHDACKQADDGMLYVAYTAERSMGAATWKPCGSCSWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6L4</accession>
    <name>A0AC62A6L4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-dependent Clp protase subunit, heat shock protein 78 (HSP78), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0220300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009371">
        <property type="protein sequence ID" value="XUY37415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="817" mass="90869" checksum="2B1B00B360A15576" modified="2026-01-28" version="1">MMRRCLVEVAAAMQCGRTATLAAPFAPSICGGTRKAPVAAVACSLLGSSTAAHPVLTTSCRWQSTGVTPWSSSGNNDGGGNGGQQQGRTWVNPNAVPPGEFLKKYARDLTEEARMGRLDPIVGREEVIRRTVQVVSRRTKNNPVLIGEPGVGKTAIVEGLAQRIVKGEVPESIKDRQVYALDMGTLVAGAKFRGEFEERLKGVLKDTIQSQGKVILFIDELHTLVGAGSSGDGSMDAANLLKPSLARGELRCIGATTLDEYRQHIEKDAALARRFQSVLVTEPTVEETVSILRGVKEKYEVHHGCLIKDEALVYAAVNSHRYLSERRLPDKAIDLIDEAASRLRLQQESKPEALDLIERELIRLKIEAEAVKKDKDEVGKEKLVNLYEHISQKQREYDVLEERWKREKSLFQTIKQHTEELDVLRHHLEKAMNSGDFAKAGEIQHSQIPNLLKQIEKDKHLASSKNFMVHDSVTSKDIAEVIARATGIPVAQLMTSEREKLIHMDVELKKTIMGQDAAIESITNAVRISRAGLHSHKRPLGSFLFLGPTGVGKTEVCKSLAKFLFDDESFICRIDMSEYMERHSVHRLIGAPPGYVGYEEGGELTESVRRRPYQIVLFDEFEKAHPGVSNILLQVLDEGHLTDSHGRRVDFKNTIIILTSNIGADVIARLPEGVPSSKAMPAVMEQVRQRLTPEFINRLDDIVMFNRLSREDIRSIVVTLMAQVQKLLTEHNITLEESEAVYDWLSVNGYSAVYGARPLKRLVQSELLNQLALMLLDGRIREGEHVKLSVQDDHVVVVANHTLSPEKGLSDEQLLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHR1</accession>
    <name>A0A088RHR1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPI-anchored surface protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_050750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="AIN95517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703839.1">
        <property type="nucleotide sequence ID" value="XM_010705537.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22572153"/>
    <dbReference type="KEGG" id="lpan:LPMP_050750"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_050012200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_050750"/>
    <dbReference type="eggNOG" id="ENOG502SJPI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267946at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001838946" description="GPI-anchored surface protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="690"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="729"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="778"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="932"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="983"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1058"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1093"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1213"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1260"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="733"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="824"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="932"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="990"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1000"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1093"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1230"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1290"/>
            <end position="1299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1408" mass="144655" checksum="1A067740531D4BE0" modified="2014-11-26" version="1">MVKAVVMIILVMGCACVDECPSASPFSDPSRCSPPNATSEGIPHRKRRAALRVHPHLSHLLSPSAANMTSLPPPPPPPLLPPKCCLQPLITYLKRGRPVMRSAAAAPPSTIAVGAALLPMNDLRTGMAPAALPRDHDPQSTRPAATSPSPPMPTCRRLSYNSAKTGSSSRSHTRASPSSVASSHSCVRPPSQQQSQKLQHFWQKPVPVAEVATTTASLRSTTAAARATVIAADTCAIRHDSPLVARSRSPSICIGSAASPCSPEAPPFAATVAASATCAVVCSAKRGSGGTALLSHVPIDGRRGGATTAVGNGSTSPPSATIAQAVTATVIVKHRTPGRAKGPSLLSLPSLSSAAVSPRAAAPRPLPARHHSAGTTTLASSGLPVAQPQPQRAAPPPQRRRSRSASSGICGAGTNPNNVYFQPAPTLRNVGAGDPSPFSAGQLAMPRRSPQWPAVAPALTVAATTTRTVQQRAPPVQLVRPAELHRSATMVTRVAAAVQDRLQPPHRSKLARTLSVTSVQHRRRTPSTGSFDGGSDSARNTESVASASLFTRRASISPLGAVAEAPGGRSIAPTASRRPRLSTASGPLSTYTTRGARSGGSPAGHIEPWSSDNGAPDFVAASNNTTAEERTLLRKDVVRSSSAPAHKQRHARSSSRTSSAVPGNLASQAPRTADGCGALAAAPPLLVRSASVSSAHQRRPHTSTDNPVGIVATAASGPATVSTSFVRTSLVPRRSQSRNGTSGTTRSGATGKNALTSLGTAAVSITARAPNVNIDVTARRANPGATRPTIDSTAGAGDPCSRPLASTEAGLRRLASRKPRDGGSKNTVSASQSSMIEMEESKAFLQEFQRMNERELALFGTLLATVASEQQQRCDLGIAGGAALGADKADDTAMLSSAAGDRAAGIAPSTGVVVSAEDVTVWACKRAVSLPLHQQQGQSKLEQTSGMPPPTTTTPGRPEAVAPPHLHADDELIVLVRRSHSCTASLHAPPSSSMSGSEAQQLQTDQLTQRTDGTKGQDDAHLVTSPHAAVRPPPHQQQQQGIVVDTAAGSRSRCYATALHRASRSPSPAPPPLVSTADGKENDLQTLLLNSASSTSVPASSLPTPTCAQAHPGTTRVPQQQQQQQQVGMLASACPDMSGSGGLRPRAETDVNTSANRTAAGAAWKSSVEAMSRSTRTVRKELPSSTGAAAATAGTVRQGMVCDGPSSAAAAAAAGRIRGGGRRRCGANNGKDTSPSPPEQQRQCNAEGYADIIRRYIPNGLEESHDGNGIDGCDNNLKEGGVPFDEDPHSAGASASSLSRAASEASAPLAALKRAKEMAAELAAAARTKTIAADKYSAAMMPTPFLSPSIFSFADSPTSGSASMSRASGGYATGAATEISGVRVTAAQLQLLIDGSRSQANYARYQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RI23</accession>
    <name>A0A088RI23_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">L-type lectin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_051070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="AIN95548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703870.1">
        <property type="nucleotide sequence ID" value="XM_010705568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RI23"/>
    <dbReference type="GeneID" id="22572185"/>
    <dbReference type="KEGG" id="lpan:LPMP_051070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_050014800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_051070"/>
    <dbReference type="eggNOG" id="ENOG502RCSF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270293at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000275">
        <property type="entry name" value="Putative unspecified product"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051136">
        <property type="entry name" value="Intracellular_Lectin-GPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005052">
        <property type="entry name" value="Lectin_leg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223:SF34">
        <property type="entry name" value="L-TYPE LECTIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223">
        <property type="entry name" value="VESICULAR MANNOSE-BINDING LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03388">
        <property type="entry name" value="Lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001838964" description="L-type lectin-like domain-containing protein" evidence="6">
        <location>
            <begin position="27"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="L-type lectin-like" evidence="7">
        <location>
            <begin position="43"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN95548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="505" mass="57625" checksum="92677D7DB54F2E9D" modified="2014-11-26" version="1">MEAARLAVIPLALFLCGCACASNAAAARVNDDLPPGVIRGPLLHEHSFQEPLVNDWWEEGVPHYMIGGSAVANERFLRLTTNELDDHGFAFNTAPLDHDNWEARVRFSIRPPPPAADMSGSSAHYQGGDGMAFWYLDQPIGDDHQHVVKYSKSLSPELRDEMLDAENPWRVADFLLNGGDDDDDEGVDEDDLTVQEMQERQQAKERRTAKKKKREELFKRLFKRGTSVDESDREPRIMGVKFSDFKGFGLILDSVGDEKEHLDERQLEGDAVQHHHHTSSIYLLLNLPNHTVSSESTVVNNFDPTRENFRKSVDVLRCTYDFRQKGTKPYDPKAHLMDEATKVTTAAEEPLELIVRYYQKKLTVIIRREDVAKREVSSVVDEMGKATHEVEVVRTYTETMCGEVYPIHLPLRYHFGLSASTGHRPVKDRRHRSLRSVFHEADKETFTHVDVHDVLRFELRELGLNAKAMGYSKTIPLEHFDFEADKRERLHFSRQIPVSPDSDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJG8</accession>
    <name>A0A088RJG8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">DNA repair helicase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LPMP_030540</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP009372">
        <property type="protein sequence ID" value="AIN95289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700997.1">
        <property type="nucleotide sequence ID" value="XM_010702695.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22571920"/>
    <dbReference type="KEGG" id="lpan:LPMP_030540"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000023900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290029200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_030540"/>
    <dbReference type="eggNOG" id="KOG1133">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267079at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034085">
        <property type="term" value="P:establishment of sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF41">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE DDX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="5"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="33"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="240"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="309"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="420"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="578"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="626"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="879"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="164"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="316"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="352"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="362"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="585"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="633"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIN95289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1459" mass="156414" checksum="8DDEDE06C2CC3BA0" modified="2014-11-26" version="1">MPRVGPYQIPFPYAPYPLQEHAMTALRDYLEQHRGSEHTEGISSRSQSSNTAPVAVLSASSPPPSPMATSASGTRGGPSRVAVLESPTGTGKSQILLNSVLSHLFEPVENANELDGVASASCCCIAAESPAAMETVAAHEPERSTLVHPPTSQTLEEVLRQRQLEEEVAQARRERRARVRAQRRQIRQARKRMRFQQQQLTDSGGEQDFLLTQDPLVWYAEQRSMTTMGLRGDDLRGLCSTSSLSASSSSSSSSSSPASEDDDNDDAEGKLETALSTLIPLRKPKVYFASRTHTQLQQLMEDLQRTAFAQRPLRPQQRTSESLGNTAERSAGAQVGANGRDDCAAPSKSFGSPPPLSPPEAVPSSMPSRQQQQPHRLTAVHVAGRQHLCLNAGLRRKAGCNYDRLNYYCREAMRFERSKQGRQYRRQQQEHAQQQPRHFTGSPDVRDIEAAGAQQQLGQDRGCVYCVESHLRSLLVYLRDEQHRADAATNPDDDGAGSGHGGLPSSVYTMDRLRRLGAELQACPYLATRLLLRGADVAFIPYGYVLDENQRAVLLGGAATNPATAAEAAAAAFAMPSRSTPASEAGGGGGGVAGESGDVASHSHPSLGAVLYHRRQRLTTTAAFRRRRQQQQHGGSPSPTTISLHPRRSSVNEDDDDEADAMWRTMACGAPPSFHGDILVFDEAHNIADYCRSASTATVALWQLLLARRLLEMYMERYASRLLTRNKQRLRELIQFLSKLARFCERADSSVFLAEGGGGDGDVASSISGPSPLLARHPQSSPTSPETAVCTRVLPFHTFLFNAGIDNVDVYAFLTFLVDSQLVMKLQGLVSYALDAELHSEQEGKMTEPAMTAARTTITSGTDNRASLTAGVKRQRGSGFDVGASDARSEAQRQRRCLGFPGPPENHTKTAGEGPSPPRLSLAELLLQHLKATGAAATCAGVTASPDPVQLRALAAEALQRVERLLCALYVSDSTSTRVLWTPSSSTSPAPTQDAGDAARQGTLKVIQLEPGTYTFAPLVREARAVVLAGGTMQPLAFTCGPLLPAPTNLSGGTRGNGEIANMNERSAVGVAAGGVDKRNHISNVDVSLQGGVGCASGLPSFHLISEGHVVPSSSVQVWALGTGPSGLRMELSQQALGLRGEAASTAKDTASLRSDTNRVISPHAHRVLAEVGCTLLNLARVLPPAGAICFCTSYDVLDTLVAVLESTGYYAQINELKRIFTETRNGGGRRGMASGDEGGSGEAIAELLREYQEWISGELGGDGDAEPALGPLSTAASASLSSNAGAPQQPSRRGALLFAVMGGRLSEGINFADDLGRAVVVLGMPYANPTDVELQMNLKHIVTTRLMTNTDASRRGMCGSAGSVSATSLSSSSPFTSAEEWSLYTEGMMRTVNQCIGRCIRHAGDYATIILLDARYTERQGIRRRVSAWLQPSIRVAQTFGQCFSGVREFFVGRQPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RK57</accession>
    <name>A0A088RK57_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lanosterol 14-alpha-demethylase, putative</fullName>
            <ecNumber evidence="7">1.14.14.154</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_111090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.154" evidence="7"/>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696956.1">
        <property type="nucleotide sequence ID" value="XM_010698654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RK57"/>
    <dbReference type="SMR" id="A0A088RK57"/>
    <dbReference type="GeneID" id="22572974"/>
    <dbReference type="KEGG" id="lpan:LPMP_111090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_110014700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_111090"/>
    <dbReference type="eggNOG" id="KOG0684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11042">
        <property type="entry name" value="CYP51-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000095">
        <property type="entry name" value="Lanosterol 14-alpha-demethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN96303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="479" mass="54161" checksum="827A5E54701E8E48" modified="2014-11-26" version="1">MIGELLLLLAAGLALYGWYFCQSFNTTRATDPPVVRCTTPFVGHILQFGKDPLGFMLNAKRKYGGIFTMNVCGNRITIVGDVHQHSKFFTPRNEILSPREVYSFMVPVFGEGVAYAAPYPRMREQLNFLAEELTVAKFQNFAPSIQHEVRKFMKANWDKDEGEINILEDCSAMIINTACQCLFGEDLRKRLDARQFAQLLARMESCLIPAAVFLPWILKLPLPQSYRCRDARAELQDVLSEIIIAREKEEAQKDNSTSDLLAGLLGAVYRDGTRMSQHEVCGMIVAAMFAGQHTSTITTTWSLLHLMDPRNKKHLMKLHEEIDEFPAQLNYDNVMEEMPFAEKCARESIRRDPPLVMLMRKVLKPVQVGKYVVPEGDIIACSPLLSHQDEEAFPNPREWNPERNMKLVDGAFCGFGAGVHKCIGEKFGLLQVKTVLATVLREYDFELLGSLPEPNYHTMVVGPTASQCRVKYIKKKATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKK9</accession>
    <name>A0A088RKK9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Calcium uniporter protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_130490</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCU (TC 1.A.77) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697131.1">
        <property type="nucleotide sequence ID" value="XM_010698829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKK9"/>
    <dbReference type="GeneID" id="22573159"/>
    <dbReference type="KEGG" id="lpan:LPMP_130490"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130009000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_130490"/>
    <dbReference type="eggNOG" id="ENOG502S8GX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="278338at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990246">
        <property type="term" value="C:uniplex complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015292">
        <property type="term" value="F:uniporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036444">
        <property type="term" value="P:calcium import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006769">
        <property type="entry name" value="MCU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039055">
        <property type="entry name" value="MCU_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462:SF46">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04678">
        <property type="entry name" value="MCU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium uniporter protein C-terminal" evidence="12">
        <location>
            <begin position="187"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIN96478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="328" mass="35781" checksum="2584C4F7D75F9DD7" modified="2014-11-26" version="1">MFAPTPIMRLMRDRAATRCTRFHPLFRLPPKPSARRSHSTTAADAAAKTKLTSPGAPLSHVFEPLTTSGAASSFSSVSPSAIVLHTSYASFPAANEVGHDVSRSSGAGAGDGFTTADHFITTPSYTVTDVAAFEQLIAEALRLSQVTLEVAATADSPPAPSPFSPVSAASAPQGGARQASSTLIADHTVRELQVLLAEAEHTLSPSLARKATIDKFVYGVYLPLLRYGVFVILVTQLVVYFHWIFFVFDWNLVEPTTYFLSYTGVFCSLVYHYHRCGEDGFTWRNTLQHLANRKAEKTYAKQQLDVAGMAQLQRRIALIKRELARMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKQ3</accession>
    <name>A0A088RKQ3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_130890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697171.1">
        <property type="nucleotide sequence ID" value="XM_010698869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKQ3"/>
    <dbReference type="GeneID" id="22573199"/>
    <dbReference type="KEGG" id="lpan:LPMP_130890"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130013200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_130890"/>
    <dbReference type="eggNOG" id="ENOG502S6EK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273456at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="460" mass="50144" checksum="BDDC593C7C4490C6" modified="2014-11-26" version="1">MMSSASTRRGGAPATSRAGHPARSNTSGNANTSGERPQRPRAPGHVEKTTSRAGTAPQAEEPEKVKYTVIITNVENDFGKLHKACLPYYCGLRSDYEETLDVERLIHEGGPQSRRLIGAVRGCSYAVRCRTETRSAEISLYGPANADFSPMQLNKTSRRPPTPAGSAKSVGAPTSSSSAKPGPKKATVPAEDMSEGAAVANVGAVEQLALRLRQQHYFEEKVPVRVHLPGRIADEVLVRVKKGPAPSGTDGLGDTTVKSEERVEAQEDADVHGSGVTPLVLPASGEKRQRVYAEDNNNDASSPQRVKREAPEDDEGRRDEDDATAHKNGETAADDVNQSTNCSGRWSKQLKKSVPATIITQFPRRQKDFVTAVAALSCRVPLQRVRSCLRDLPGYLSCWCLYEQHLRVVFRDAESLFKAKQLLDQFELEPGLRVSLIFSDPLSRANAEFVRAQEMENASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKS8</accession>
    <name>A0A088RKS8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_140310</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697265.1">
        <property type="nucleotide sequence ID" value="XM_010698963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKS8"/>
    <dbReference type="SMR" id="A0A088RKS8"/>
    <dbReference type="GeneID" id="22573298"/>
    <dbReference type="KEGG" id="lpan:LPMP_140310"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140008100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_140310"/>
    <dbReference type="eggNOG" id="KOG0178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000058">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1 2 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="5">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="257"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="263"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN96612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="285" mass="32181" checksum="7D2C9EADD2D9DC67" modified="2014-11-26" version="1">MSHRYDSRTTTFSPEGRLYQVEYAVEAIQQAGTVIGVCTKGGVVLAGEKMVPHPLFDSENMQDKNTSGEKMYKIAEHIGCSVAGVTSDAYALLNYARLAAHRHQYTFQEPMAIEDLCRMLCDEKQLYTQYGGVRPYGVSFLLVGWDRYYGYQLYSTEPSGDYSAWSAYAIGQNDQVAQSLLKKDWHNDMTLQDGMLLALRVLSKTMDTAKIDLDRVEMAVLHKVSASSADELLDPFKHHPKMIPQFHILSRSELKPHAQCADQAREAEEQAEAERQRLQEQALES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKT9</accession>
    <name>A0A088RKT9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Phosphoacetylglucosamine mutase</fullName>
            <shortName evidence="11">PAGM</shortName>
            <ecNumber evidence="4 11">5.4.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Acetylglucosamine phosphomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">N-acetylglucosamine-phosphate mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">LPMP_070890</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23804"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="5.4.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11 14">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.3" evidence="4 11"/>
    <dbReference type="EMBL" id="CP009376">
        <property type="protein sequence ID" value="AIN95774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704096.1">
        <property type="nucleotide sequence ID" value="XM_010705794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKT9"/>
    <dbReference type="GeneID" id="22572424"/>
    <dbReference type="KEGG" id="lpan:LPMP_070890"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_070890"/>
    <dbReference type="eggNOG" id="KOG2537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1928at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004610">
        <property type="term" value="F:phosphoacetylglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03086">
        <property type="entry name" value="PGM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000003">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000051">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049023">
        <property type="entry name" value="AMG1_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049022">
        <property type="entry name" value="AMG1_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016657">
        <property type="entry name" value="PAGM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955:SF1">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21405">
        <property type="entry name" value="AMG1_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21404">
        <property type="entry name" value="AMG1_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016408">
        <property type="entry name" value="PAGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 19" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="16">
        <location>
            <begin position="68"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="18">
        <location>
            <begin position="204"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="17">
        <location>
            <begin position="347"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase C-terminal" evidence="15">
        <location>
            <begin position="539"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="12">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="binding site" description="via phosphate group" evidence="14">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="421"/>
            <end position="423"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="544"/>
            <end position="548"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="553"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF21404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF21405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AIN95774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="580" mass="63681" checksum="270C3CF742896A3F" modified="2014-11-26" version="1">MFFDELMRIINSEFPLRHDPAKNPLTYGTAGFRSNAALLPPVAARVSMIAALRCMYYQGKRTAAGHNAPCTVGVMITASHNPYMDNGFKIIDPDGGMLVASWEEWCTRAANAPSGSDLKQVMMDCLAHDPNAFQLKQYSRCQVHFSRDTRPSGEEIVNAGLRTLRLLQNITPRSYPPISTPYMHFAIAKANELGLGDESEFPSYYGELLAGFEEMYLFASAGSQLCEKEGHLQQLVVDCANGIGSLMMRELIAASKQQSDFTALATFFEVHLVDCNCQDKTMLNTKCGADYAKQHTSPSAAMSAWPSASPPGVNPTATHFYSLDGDADRVVAFLYDPKRDYKWVLLDGDRISILYAMLLHKWLGEEQMKALDVSVVQTAYANGASTEFLEKQLRMQVYTAATGVKNLQPIARARDVGIYFEANGHGTVLISEKVITEAASTGSEKAALLAAMRRLVSQCCGDAIADILMCEVALRALNMTFQDWADLYVDHPCKQTKVTVAHRDRITTTLDERRALSPTGMQDEIDAAVSLALSRCEAARAFVRPSGTEPVVRVYAEATDPSVCESLSAEVVKIVEAYCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKV4</accession>
    <name>A0A088RKV4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_131360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697216.1">
        <property type="nucleotide sequence ID" value="XM_010698914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKV4"/>
    <dbReference type="GeneID" id="22573246"/>
    <dbReference type="KEGG" id="lpan:LPMP_131360"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130018300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_131360"/>
    <dbReference type="eggNOG" id="ENOG502S8VQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267427at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN" evidence="2">
        <location>
            <begin position="850"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="822"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="890"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="830"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="902"/>
            <end position="916"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1037" mass="109253" checksum="46ABAB6839D3515B" modified="2014-11-26" version="1">MHKPPKLSERRGRCLSGPPRSKPKPAEQPTSTGERKSGQSEVTSSTPSVDTSSSGCGDDTSLSSPLLTYGTTRERRTHRSLSHSRIQSGGGFRYLRAATATPDLAPSSAGPSMRLGSKAATFSPSPAPTSLPKELREDTTAWPLEKQPLTHTSRSFSPHSSTPAESSLARLRALAGLAPLQRFSYDSQMLSPDLYGNEESPLRHSCDVRVELGGSGPSSSAPSSCVSSPYTPDLVQRLSFLNGTSAQATLAVLQNDRLKRSRSDALMPPSLPIAESFQSEGKSVGQQCKGPPTVPTANDTATSARGSPFAESLGLASLRASALTTYRNEKDVDSGHSSGTASDSAQSTASALSRLRAANQYIASAAENCSNPHPYITSKNGVAGVGPAVDVAPAPHKLPTGSQRRTAAALLTPAHLAASSLSPGPGLPRPSIVSARLAQLRQRAPTSPTSLSPDAKAVAPVTSRRGTVQAPLPPSFINLSRLRRLENLQQPRRQPSTPPSDATPREDQECNSLPSPAATLEAALENAPQYRLLAEATAARGEATPVPPAAVDSDKSDLDPAKVQKRDALLPTPANALVSYKTSANQNVHHAAAKMGVRRARARKGAAAMKAKKERAVEAVVLKGTPAKGTRGKTRLANSPVWAKQLSKLRSLAAPVPVGETASERYTEPISNSFIVSAVAPPPHSPPEHSSQHLSSAVPIKSDKALLKRSVSSLPPSWSTSSPFAALASPSLHAALTQASAGLVTGRESADSIKLKDGVPDDEKCPRESTSSSFASVSPYYCYPSMMTRSTTAAAAAALVAAVNRTLAPTTVTTTSMADATELSSQPHMRTASTGSRKSRGGSSALQCVIFDTSSLLDSEPGVMNLVLEKWFVGIPFTVLDELDRMHKDRGGGGGSGKSDHAATTTTAAAAAAAPAGVSGTHDREWRRQRAHELRNWIAACLSDAAQGRLLLQKRTEVVQAYDLHATTNDDRILGYAVYLRQQRAATVLFVTEDKFLRIKASSELGKAYAYSDIRKLVGMPPLPKVSSTASQEKRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RL92</accession>
    <name>A0A088RL92_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_150750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697450.1">
        <property type="nucleotide sequence ID" value="XM_010699148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RL92"/>
    <dbReference type="GeneID" id="22573495"/>
    <dbReference type="KEGG" id="lpan:LPMP_150750"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150012900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_150750"/>
    <dbReference type="eggNOG" id="ENOG502SH90">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267697at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="674" mass="71832" checksum="5EC106C330F66962" modified="2014-11-26" version="1">MKSFLHDDSGNNSMPTVPPRQQHQHPAQTPMASSQEYGQYSVSPGPYNPSTAAIILPAGQQQQHGLQQRPLQQNPSATSVYTLTPANPVNIGGFPGAQSPLTSMQHQQHHHVVPSPSRHSSLSELNNPSTIQLHERLLAAGAAPGVPGLVITAPIVVSPAHRWPSVLNSGHCTSSALLLARRLHPVFVDTTPPVSIVSSPSPHQQQRGTTPVRSFVTHPPLAHRAPAQVAAYAVSSNSPAGYGSDNIRSPFQQPQQKQPPYPPAPIHERVPPTAPDPTSAHTTFSLASSLSRSQQQQQQLHLLSVGASGAAPEALVSFATAPLLLPSPREAAAPTTVTTTSLSALVDLDDVRQGYERPFRFKTLPPPPTFECFLMLSETNAFDRGFSRATARGEEVTNSNSVTQQQEIACAGSHKSGGAAPATGRGNMEAVLRASTNPRGEPRRSPSDFVSLSAAEDNDGASDGAAQCKAAAAISEPDNKSMSSESRHSTPEWLAMVAQYHHVLERWWTYMVIFENKPEVRQRLGNLHQCPSFADAQQAVAAAAAASSSPVGGGCGTLDGGATDPLVAEEVVLQAWSTLALQWWEETKQRRRPRRSHRRAPCGGPPPTRMDDEGVGGSRSGNETGETASLASVNPYELLSAEEGHLTRSLPPDHDALLHFDFTIQSALSSPTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLA2</accession>
    <name>A0A088RLA2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation/H+ antiporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_140950</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697326.1">
        <property type="nucleotide sequence ID" value="XM_010699024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLA2"/>
    <dbReference type="GeneID" id="22573362"/>
    <dbReference type="KEGG" id="lpan:LPMP_140950"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140014700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_140950"/>
    <dbReference type="eggNOG" id="KOG3826">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="423807at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051843">
        <property type="entry name" value="CPA1_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31102">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31102:SF1">
        <property type="entry name" value="CATION_H+ EXCHANGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="473"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="521"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="548"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="580"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="616"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="699"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="7">
        <location>
            <begin position="299"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="730"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="766"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="741"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="775"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN96673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="785" mass="85998" checksum="00A08CB249F3314F" modified="2014-11-26" version="1">MSSRDTHEGSAARSLPQHEGGAASHDSNPVVPSLSHLSHPYADGDGGSVFADPRSTSLGGESHQSEMVADPLVPEKTGISATVLSAQPADRSCRPFSPLFRHTPCGFGNVKWKASEDSHHDLTVPPSNVRVADCSQPRTPESMGRYRHHNSSSGSLSTSLCYSDSFVNQTYIKDLPPHLLPLAHEIHNLGEKDLVYIADVTHTMANRDLYSLLPYTGSNWFLPLIRECDEGEKHWEMRYCWKEGLIVSIGGRRLSIRALNIFIRICFLVLIWFLLWNMLPRWLVEPGGYVWDPAVLVVVSAIVGGLICRVLQLPPLVGVLWVGIMWNNIPTLKYLTHGIVKEVYDICSKLGLTVILARAGYKLAVKDIIPHWKQTALLATMPFVFEGISHSLIANKIFNYNNNYNWAFLQGMLCSIVSPAVVVPGSLYLQDMGYGCGVGPLSLMLSAVGIEIVIGVWCANFIIGLIFNDQKLAVAIVLGPVQFIGGIAIGIGLGILFFYVVELIKLEAHRLPNGKYTRAHLNSCMDFAFTIFLLGCYAMVFFGYKMNLAGGGCVMCVFFSATVAHMWSRTRRMEHEDHKKYVATWLAMSWNQVMMPVLFATMGAKIDVKAIFNSSFFPRAIICMACSTVVRFIVTFAIQIGSGMPWKEKLLVCVGYLGKASAQASVGPIAANLVANMIAALPEGEKHSLDTMAEYANNVQQISAMYVMFMSVVASFGLVRGGQLVLKREQTPEKRKGCRVSGSSSSGDAATSAMAVAEMVPTVAETGQPAYPLPTAQQQTNTSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLI1</accession>
    <name>A0A088RLI1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyridoxal phosphate-dependent decarboxylase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_160430</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN96917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697570.1">
        <property type="nucleotide sequence ID" value="XM_010699268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLI1"/>
    <dbReference type="GeneID" id="22573620"/>
    <dbReference type="KEGG" id="lpan:LPMP_160430"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160008500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_160430"/>
    <dbReference type="eggNOG" id="KOG0628">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="639767at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000288">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF70">
        <property type="entry name" value="MIP05841P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="435"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="449"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN96917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="565" mass="58830" checksum="08392A26A42B931F" modified="2014-11-26" version="1">MRTTSGHIAPRPLTSSNPSSVAATAPLTALPTVATANEVFAKASTRTPTLPNAAADGGGALYSTTLEAYTILLHTARTQAVTRGSGQQNAFAGSESAKQQSSRLVLYCGDQCDALLVRAAQLLGIAHVRVIQTVAIKRDLPLPTAHSTGTAVTGGESCSLYNYAVDVHELQSRLVEDVAAGLYPLMVVGTFGSGLSGAVDQLLAMGEFCQRLGVWYHIDASHGGAALLAGPAGKGAPPALLQRDAVLAQFYAAASLADSVLVPTGLSTAMPYATLPVSPASCFTTTGSMALFFAHIRKVAWSLQALGEARQHTFNQWITPGVAESDVLRVSPLSHMGGWLLEQHLTGVLMTAKSSKANPRGVVPPVSASSSVLAERVGAHQQFVRAVLQAVRGDGRFDASIDAAVFGIVCLRWLTAADEATVQLAHAWSDVLTEASHPPVTPQDKRVASTPTHQSSSYSTLSASGPSETDVEGGRCAVPPVQVFVGLVQLQRRVWVHISFGPLLGLLEDEPASFATAAKALASGALESDPVSSTRTRALAYVKRTLNKAASLVRTAPAAVNIPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLP1</accession>
    <name>A0A088RLP1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_141270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697358.1">
        <property type="nucleotide sequence ID" value="XM_010699056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLP1"/>
    <dbReference type="GeneID" id="22573394"/>
    <dbReference type="KEGG" id="lpan:LPMP_141270"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140018300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_141270"/>
    <dbReference type="eggNOG" id="ENOG502S8T3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267725at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="651"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="762"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="448"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="806" mass="87288" checksum="95C2F0CD94B3F517" modified="2014-11-26" version="1">MSSLIQCTDDLLRQKAVQSSHYERLERQLLDGERCRRTAILALRQRAADVTRRGKDVADLRRENHQLADQLAQHALQLAALQCRSTEAKKRGLAAVERLEDGIRSFSGHPARVVLLVQALQAQTQLHCAGRRFSKALRLLWATLRVHRQAFVFVAQSTRVLSSHAALHARLASVLRDRVTRCLEMRDAACSRSQAATAAREGRVMAEQQTAERKLLAVKAHSDFLSVYTEALDDMCRAAKEDVAALSATIDNYDAPLSAMHETLQEKAAAVSEAKQSLTAQQTAHAEALKLHEMHLARTTEELSDLVTAEGLANTHAAELQRSVHSEEKHTQPLARRVYALAFLILLCERDQLRFSQQRTAQAEERTKVELELTQLRTWHEERLERLRATRAAAADAAARDALLLREAQGRKAAVDLEEDEWRLLYAQLFHDVCRARADASAAVAAAKSARRPSAAGGREEGEEGRSARRSQRKRARAVRQSHVTKTTASRRQRAALEAVDASTLTSSQHSNPGYRTTTHVDEEVAAAELTAQEQRSGAARVMTNNHATPQLQLTASSTLRPSYRLTSVKPATVAKKPTRAAPVAAASRASLSGKKRKANGGAVAGAGGVQHTPAAAAARVSAMSPYTSAVSDESSDSSFSLVNSRKKVAAETDSWSDMSDIRLSSPSPSPRCPHGRRAGAVPPIAAAKPLPRPVLRHGCGEAAVTTAQHISGSALASALAACTPRGPAIGRDDGQTSAHSSSFLPHFTGNFVALPSVGSGTRLPHTSLPPRPTMSKAVPPPRRRVPFLAASFTDAGEDLFADMFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLT9</accession>
    <name>A0A088RLT9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_150580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697433.1">
        <property type="nucleotide sequence ID" value="XM_010699131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLT9"/>
    <dbReference type="GeneID" id="22573478"/>
    <dbReference type="KEGG" id="lpan:LPMP_150580"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000042900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_150580"/>
    <dbReference type="eggNOG" id="ENOG502SAB5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410807at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="234" mass="25963" checksum="4D869B09029AD44A" modified="2014-11-26" version="1">MPLKKNALMYSIDPELYARSHAPATTVAMGMKSSQASSLCWANQVRREEAIREMWGTTYDPQRNREKKALQAVQQTRARDAARHEAYVNPENNPELYSILYKRPPPSSVCDSGVTTASSSSPQHSTSTATPEETAKDTGNSGNNSFARYARSTTHEYLQARCRSHTLQQRYPSGPATAAQAVGWAVGATGRTSVSSSEASFSPHLRVRRRQMGTYRKPEDDEHALLFGYDYAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLV4</accession>
    <name>A0A088RLV4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_150830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Rab GDI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697458.1">
        <property type="nucleotide sequence ID" value="XM_010699156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLV4"/>
    <dbReference type="GeneID" id="22573503"/>
    <dbReference type="KEGG" id="lpan:LPMP_150830"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150013400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_150830"/>
    <dbReference type="eggNOG" id="KOG2920">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4405">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="46564at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000654">
        <property type="entry name" value="Rab geranylgeranyl transferase component A, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF4">
        <property type="entry name" value="CHM, RAB ESCORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1050" mass="113958" checksum="8AE1712399257A02" modified="2014-11-26" version="1">MSDAEGFGDLFGGVDEVLELPLQTLLISRQVLAEEGTTCDYFTPLLDRFDNITSAATAANDHTRLRQRLARLAPPPLEVRFRDKRHSLWGHTLWNAAKYLVKRMDERLIDVRGKSVIELGAGLGVPALAAYKNGARLCVVTDYPDADLLDILALNLKANCGPGDMDADVKSEMEEQARKQLAKGGDSDTVSADQLGAAMSTRYYVEPLLWGSQEHIDKVMQHTTGGAGYDIVILSDILFNHVCNDDLADTLATLLAKNPRAAGYCVFSHHRAHKQLHDFEFFDKCLRRGLHYEQVDEQDYPMMFPEDRGPESVRRPVKCYKIAHRYDDAGCGLDTSLRFDVVLQGTGIAQSIVSAALARNGVKVLHCDGAEYYGAAMATFDHAGFLQYLSQPSSLAASSSTSSSTAPNVFINRIVDEVPVARRRRYLFDVLPMCYMAHGPLLRHLVSSGTGRSLECQHVHRFLFLQHATTTGATGAGAAVTAAMEVPLTRASVFHSTSISLFDKRRMMRFVKDVEASVVEQLHAKAANPADDPSVVNTSIAAEAAAAKAAAIFTCEAQSNPQITLTELLQSKYDLSGTVLDVVSLMGMMNVLPATNSTTLTSGQGAAAEPPLVQSVDMVRDLLLSTGAFGGKSPYLATSYGAAEVPQNMCRISAVWGGVFVLRRSLRGVAVDEAKETQYAVLSNGQWVPAKVIVTPAELTATNYLSYGVNDWYYDFLKEQEQGRTPLIPLSEGQGSAPAPAIAPDQTKMSHKDAADETASALASPAGAVRFSRVVLATKSAPLFSLAAMQAAGVIEVDDACDYTAAAPIITALAREPQTRAVVWVIQQSFASDQAPARFTSDDADGGATCDPCVLHFTADANQLSQEQLHAYVMRYYTSTEKAERPYCVPHDDIVLAAAFTVDSQEVAQHGVVPCPVELPSETRWTHPFGWVESMKLRRANENDRQHLLRHQMTEEDATPATTAPTLACSATAQTADLCRSSEHFRLIEIPTLLPNLVYDGHYVQEAEKAYKRVLDALGLPTAATATSAAASEADEDAAQAYAFLRPLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLZ6</accession>
    <name>A0A088RLZ6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_151380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697513.1">
        <property type="nucleotide sequence ID" value="XM_010699211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLZ6"/>
    <dbReference type="GeneID" id="22573558"/>
    <dbReference type="KEGG" id="lpan:LPMP_151380"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150019400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_151380"/>
    <dbReference type="eggNOG" id="ENOG502SF8Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="263502at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="95" mass="10748" checksum="0672CD2B5C88DE56" modified="2014-11-26" version="1">MPSTPLDNTPPTDSRGEATHTLPGTRQAPCVNNSLPTQEKSCGHVRPNTDVYVSEELLDMLSEDRRINRRHHLVVDKVFKAYMLEKKNFAGVMRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RM07</accession>
    <name>A0A088RM07_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Condensin subunit 1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_151530</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697528.1">
        <property type="nucleotide sequence ID" value="XM_010699226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RM07"/>
    <dbReference type="GeneID" id="22573573"/>
    <dbReference type="KEGG" id="lpan:LPMP_151530"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150021100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_151530"/>
    <dbReference type="eggNOG" id="KOG0414">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="436262at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000779">
        <property type="term" value="C:condensed chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010032">
        <property type="term" value="P:meiotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026971">
        <property type="entry name" value="CND1/NCAPD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032682">
        <property type="entry name" value="Cnd1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222">
        <property type="entry name" value="CONDENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222:SF2">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12717">
        <property type="entry name" value="Cnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensin complex subunit 1 C-terminal" evidence="8">
        <location>
            <begin position="1001"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="158"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1237"/>
            <end position="1257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN96875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1257" mass="140764" checksum="A09345CF59E5428A" modified="2014-11-26" version="1">MSELLEFFIPSHVADLEDVAKTGSNCYHIDTVCEFDIPERQQLDDLTRLFGALHHEKSPTALFTKQDLFFPLYSYVKAIRGKPEHSTAVTRVARHKICHEVGERLKKLLQVAVAFLKKQTAGCARNGALEVCLRSTLKMYVFLVCNVLLSVAPLDEYEGSSGLSQQHSHRKRSRRDMEGSFGDDGSGVDMDGRELVLTALVEFCSPEVMELWSDCHLEDSTLNLVLKMCFHMVTLKQNIGGDAQSVGGALALLFARTSNCILAKSSVVKPTDLVVPLVELSLKSESASMFLSKLVSDIEQSETSVGFGDQLLRAVFEMMSQAALCEAATDSAAAKNVACFFSEVAKRSITAVVKMADLAIPVLQSENYDVRKAVVTCIAEMVLQRYTGHARNAQDDAVRNSYLNELLFRVMDVNAFVRNHVLHTWGRLVESRAVPKRYHLAVMTALVGRLEDRNYLVRDAAMTVISSVLRKNWFGSVLNSALVKSKLEEALSDGVVCFGEAAAMEKEIENSKKQLQPTTEVLDDPLDVDDEEGLRAAERQGAGRSREEDSVMSDKQTAIVSRIVFYQNTLCFIELIKQALQYACVLLDSKTERDVIESIKLIVVCSEYRVQGGERAFLKVLVMVFEGEMKIQFAVRDAFVEVVFNAFNRVTTSAGTRVAASAQKLISLLRCASEGEVSAVDRILGLMKANPAFARHLSAPFVEAMWCIAEGSIDAKATDGDRRIAMRVYSLLSKYIWKDLRARKDSIAEFLCSDSHKDNVLLSYIFAALQNEALDPQFHPIPADEDVRQHPVLRHVVNHLCRRTEGMASWMILAEAGVNVIHNLCEVPVTVYRYILEYYGSCENLETQPNRKAQCLFLLGHTALKQLVAVEAAEKAQLKTLEEPTKVSTQVTPTVRNQADWMHKELGLGSHELRRHEIQQLAQKRKQAIISSGSVWARFADMIIATCRKKASVYADKPFERVCAVLALCQYMIVNEGFCSDHLNLLFTIVADKRESWVTKVNVVIALGDLVCVHPNLLGPYLSVPTTGFFKLLVDEDVRVRAVTIQVCSHLVLGEMLRIRDHLYTIVKLVADPDETIANNAITFVQNLAMKEKEKTGNLIPPLAAQLSNLLPFDKFQLAMRTLLERVEGDKPTDSLIDRLCQRFESFSERSRKKLAIARNIAFCLSELNYMTERTIKRLTSESCYQQYKHWLRCADVYEYFKLIATKAKRQGARGGAERRDRAAIDEWEARMQVDSCIDADGEERSSVAADQKASDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RM34</accession>
    <name>A0A088RM34_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription modulator/accessory protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_110580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696907.1">
        <property type="nucleotide sequence ID" value="XM_010698605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RM34"/>
    <dbReference type="GeneID" id="22572923"/>
    <dbReference type="KEGG" id="lpan:LPMP_110580"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_110009800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_110580"/>
    <dbReference type="eggNOG" id="KOG1857">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="995477at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.310:FF:000002">
        <property type="entry name" value="Putative transcription modulator/accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.650:FF:000001">
        <property type="entry name" value="S1 RNA-binding domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.140:FF:000019">
        <property type="entry name" value="Transcription modulator/accessory protein,putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.310">
        <property type="entry name" value="Tex RuvX-like domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="entry name" value="YqgF/RNase H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041692">
        <property type="entry name" value="HHH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050437">
        <property type="entry name" value="Ribos_protein_bS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018974">
        <property type="entry name" value="Tex-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032639">
        <property type="entry name" value="Tex_YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724:SF10">
        <property type="entry name" value="S1 RNA-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12836">
        <property type="entry name" value="HHH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17674">
        <property type="entry name" value="HHH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09371">
        <property type="entry name" value="Tex_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16921">
        <property type="entry name" value="Tex_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158832">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YqgF/RNase H-like" evidence="2">
        <location>
            <begin position="457"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="952"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="970"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="994"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1026"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1045"/>
            <end position="1054"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1081" mass="118357" checksum="C13EF2177E506E96" modified="2014-11-26" version="1">MVARADKGAMPKRTRKASAARKLLPATGKRKYTRRATAAAPTAVDGAIDDTTVGAAAYNSSKSAIEVTHDPSTQCGGDGALSTDGHDTWEEEEVYSGRYELSPEETYRQTSARLLLPLHAVRFVLTQAKEGATVPFLARYRQGETGRMDEMQLRLVMDTAKEVTEVHRRRQFMLRSLESRGLLTPALQSALESMAHVSQLEDAWEPYKERRTSLASRGRAAGLGPYAEALLHFNPEDPECKVRLDELSALVHRTDDGERLLTAIIAEDVQRSGELQRRIGEYCRHTARLSCTLMTKPRKKVARELQEESFEALRRHFAYYDKKSWSVQRIAAHVVLALQRGEAKGALKVDTESGPKSHGLFMHTVREQYPALNRLLPLSSSSVPTADGAGAYSHVFHAFSYGRKIVHAGLQTAYDHLVKQAQFAIRRDLKKSAEREAIVVFAHNLHHMLLQRPLSRSRILAMDPGLANGVKCVALDEHGAVETFFTCTLMDEQKMRRYVIQVIESKKLNKVVIGNGTASGRVTDLIADLIKQQKWEDVEFAVVSEAGASVYSVSDIAKEEFPNLDVMYRGAVSIGRRVLDPLSELVKIPVRSMGIGMYQHDVNEKELMRELNYVLESCVAKVGINAASANRCVMEKVPGINKRVVDQIVLVRHARKLHSREDLRRVPAMTESVYQQIAGFFRFPNSPEPLDNTSIHPESYPVVRRLVMLYTAGQLGDGEMMAKKPEDAAGGAATALGNACTRQQVAQQLERMSPTQLAKLASEKLSCNVETLELLRQELLHPGLDPRASLPHAGLLRREVYDVKSLRPGQLLSGVVQSVTMFGAFVDCGLHDSVLLRGEGVDALQVGMYLNQCICFDSLDHLKRPRMLLVGPPAHAASGASADGMKGGASSAAPRRLRLEAEDVLGSNGRGFVSQAAPAAGLYDLQASHVQGDITAAAPTLTVRVMQERKRRAGEALGSANNTSIPSSMKVEERSQTNLTSREHLSHPPVTKRARAEPEADATARHVQQRVETAIVSSADARPRSTLHSPLPSVSTLKGGFTKPPANTSQTSKPTARGVHAGGVSDQHGTGGGSSDAVFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RM79</accession>
    <name>A0A088RM79_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">40S ribosomal protein S15a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_111150</name>
        <name evidence="6" type="ORF">LPMP_291800</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696962.1">
        <property type="nucleotide sequence ID" value="XM_010698660.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700785.1">
        <property type="nucleotide sequence ID" value="XM_010702483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RM79"/>
    <dbReference type="SMR" id="A0A088RM79"/>
    <dbReference type="GeneID" id="22572980"/>
    <dbReference type="GeneID" id="22576943"/>
    <dbReference type="KEGG" id="lpan:LPMP_111150"/>
    <dbReference type="KEGG" id="lpan:LPMP_291800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000007800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_111150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_291800"/>
    <dbReference type="eggNOG" id="KOG1754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="256038at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.30:FF:000001">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047863">
        <property type="entry name" value="Ribosomal_uS8_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003115">
        <property type="entry name" value="PRK04034.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S15A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN96309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO00128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="130" mass="14696" checksum="6A572BB6517B98D4" modified="2014-11-26" version="1">MTMMSVLANALRTIASAERRGKRQVLIRPSSKVVVKFLQVMQKHGYIGEFEIIDDHRAGKIVVNLNGRLNKCGAICPRFDCATTDYEKWMKNILPSRQFGFVVLTTSLGIMDHEEARSRNTGGKVLGFFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMZ7</accession>
    <name>A0A088RMZ7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_181170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697951.1">
        <property type="nucleotide sequence ID" value="XM_010699649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMZ7"/>
    <dbReference type="GeneID" id="22574007"/>
    <dbReference type="KEGG" id="lpan:LPMP_181170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180015000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_181170"/>
    <dbReference type="eggNOG" id="ENOG502QR5F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268440at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="202" mass="23471" checksum="19AA07E66CE1752D" modified="2014-11-26" version="1">MEQFMQPLEGIFRDGIPAPVLRAFAPLFQALPSLQERVEASRDCYYWRANPMKCLEEDIDTVTGFMQACEASFRMCPQQSATLLKCHMTEPARAVYFCRDEEWEWRSCLMDQTGIRFWPYANAPIGAPWSNGGQTEDFHLEDRFFYENFSFWRRRGAMLAVRERELEVAVQRKHWLDEQGDDTCLAAPKPTLAPIGINTKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPN3</accession>
    <name>A0A088RPN3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Pyruvate/indole-pyruvate carboxylase, putative</fullName>
            <ecNumber evidence="13">4.1.1.74</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_202950</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.74" evidence="13"/>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698497.1">
        <property type="nucleotide sequence ID" value="XM_010700195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPN3"/>
    <dbReference type="GeneID" id="22574505"/>
    <dbReference type="KEGG" id="lpan:LPMP_202950"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200035400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_202950"/>
    <dbReference type="eggNOG" id="KOG1184">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3970464at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047434">
        <property type="term" value="F:indolepyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000019">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000024">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF30">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE ISOZYME 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="12">
        <location>
            <begin position="7"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="10">
        <location>
            <begin position="202"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="11">
        <location>
            <begin position="386"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIN97790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="550" mass="59989" checksum="4F306A498BD2E7EA" modified="2014-11-26" version="1">MPFNGYTVSCYLLDRLVEAGCEHLFGVPGDFNLRFLDDVMTNPRMKWVGTANELNAAYAADGYARQRGLGAVTTTCGVGELSALNGIGGSFAESVPVIHIAGAPSTKSQGNRELLHHTLGDGNHAHFLHISAEVCCIAVMLTPENCLMEIDRVITEVLYQKKPGYIALPTNLAEMIVPPPPTKLMRRLPEVSPDSVSAFKHTVASHLHSSCNPAVLTGHLIQRYQCGPLVNRFLENVRIPYAPAVLGKGAVNEHLENYVGTYIAGNAPCPAKSVIENADVCISIGVQFVDTVTAVFRHKIDPLKLIDIQPFFAKVGDQIFPQVPMEVAVKVVEETAMECHTNWSTEYPDPASFRSPDSADTLDLCHVWREIQNGLRPNDVLLVDLGTSSFTSALLRLPQGCDMLCQQMWASIGYTLPAAIGAQLADENRRVVCIIGDGAAQMTVQELGTAARYRLKPTYILVNNDGYTIERFIRGWDSSYNDVAVWDWTGLARNFCKGVEPRTCLVNSVGGVEAVLRKSQDNMVFAEVLVGKFEGPLCTSVQLPGKPTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPV9</accession>
    <name>A0A088RPV9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Golgi vesicle transport protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_210360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS51 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698824.1">
        <property type="nucleotide sequence ID" value="XM_010700522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPV9"/>
    <dbReference type="GeneID" id="22574858"/>
    <dbReference type="KEGG" id="lpan:LPMP_210360"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210008200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_210360"/>
    <dbReference type="eggNOG" id="KOG2346">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="203678at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990745">
        <property type="term" value="C:EARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007041">
        <property type="term" value="P:lysosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014812">
        <property type="entry name" value="Vps51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="882"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="932"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="932"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="989"/>
            <end position="1005"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1038" mass="112119" checksum="7951E738FB551BE0" modified="2014-11-26" version="1">MHRGSAGGGNAEERRQRLRDQMKAFYGDPNASTKRAASHSSTQRNPNVPPELDLDSEYFNVNRYITDLLKRETLKGLVETDTELLRRVRRLDGELQELVYRNYARFISATETIREMKDNVVEMDAKLQTLSQNVNTIDNISSQIAQQLQVHRGHIEDTITANRMLKKVQFLTSLPTTMRRLIDQGDYSVGVKYWVAGDGFLSKHKSISSITQIQQNCCQLAKELYHAIEQHMCSYPLDDPDAMDRLRGYVEDLRLLRATSLFESANIIEEAPFEETVLQTLMKSVLASFQANVATTQRSLNAALAIPDDLQASEMAKREASLAQVNLREPLVQLKNACAMLVVNTERVYALLDAEGRSSSDRGPAAPLVTKSIQPVLLKVLQAVSQSLADFAMVHLDAIAMDGASALRNPTASAGALQVATTHLVRLLSQFVTAMKTLGEIYLPSMGHDAAEASGSAAPAADTVHLYANKVHEVACDVVRQCWERIQERLLQGPEPELLKACCPLSLSHVSVLSTVPAVDDEGAHEIAFTLTRFLYASLTQCLSTSLRTTLLGEEGVPVDMLTSITTGLERTAQQLQHRGIVLLGQLEVRLVYDKAFSGSSGHVSTATTTTTGPKVQEVLLLLLPQWATVYDVLKALPPLKTASATAAAKSKGGVSSSLYRHRDNSGYGGGTAYRVSGGSSTGTHSDYRAGGSSAVVGGSSAHLRGGSSRGKPEVSYTRQVMSRLQMSVNHIFANAETWLRTEPVVGLPSALMACVVRYLLQGILDRVRDEAAYTETQFQQLQVSCTFLLHALVSPTKGSAPRQWRKEWSEEDMLDVQRLLNEVCACAYDKYEAKVPLPTAVLDRVVETAVRSGRAALEAANISSADTAAATAVPMPSVTEVTFPGEKTKTPSLEPPQPAPIAPALVTLSPQPQQLLQEVRHPLRDDLLQSSAAASSGETPNSTAAPAPTASAAAPSPAPVTSASAPAQATPATPAQASVTLPPESRAEPAASLVPAAAERLAAAPGTTMPPPQARFSSHYNSDSRTERVDEEEELPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPW6</accession>
    <name>A0A088RPW6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Golgi-targeting intracellular transport protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_203860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698587.1">
        <property type="nucleotide sequence ID" value="XM_010700285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPW6"/>
    <dbReference type="GeneID" id="22574597"/>
    <dbReference type="KEGG" id="lpan:LPMP_203860"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200044700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_203860"/>
    <dbReference type="eggNOG" id="ENOG502S9V6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1926336at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000237">
        <property type="entry name" value="GRIP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01465">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50913">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRIP" evidence="3">
        <location>
            <begin position="381"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="90"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="340"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN97880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="434" mass="48747" checksum="3AB418B36F4F6AF3" modified="2014-11-26" version="1">MRAQIVDLTRKLDESNEQRALLEASLGNREALPELYLAQCQEFMYAHAIAAASMMVDATSLSHNGGKPEQCKDVSTTDSAMTSPSRDTVIENLQKAIKDQSNRLKEVQYALKRSTNELQQRTEALRQQDESLAEMKHRLTELETSNTSLRQQLLNAPNTDEWKQAQEDLDQQLERTRLEYEIRESQLVLQYSAELQALRASHEREVHEMQREHRDAIAETLRAAQVSNAQAAVCNSVHPPGASDVPHHGTHPGKTDDDAYLNLLSDYKAMERQCATAMKERGAMMAQQKALLRELKDILHSAVGPLPASDTSNTSVTATTSADETQATAGWNSVTDIHNLKEAVRQIHEQSLRFAGLQEELMRTRREVMQLRRSTTGPSEDSLGAQQLQYVRSVVVRLFCSLSDVHVVRHLLPVLSTLLKFTDEDLKAITKAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQ66</accession>
    <name>A0A088RQ66_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_211330</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698919.1">
        <property type="nucleotide sequence ID" value="XM_010700617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQ66"/>
    <dbReference type="GeneID" id="22574955"/>
    <dbReference type="KEGG" id="lpan:LPMP_211330"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210017900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_211330"/>
    <dbReference type="eggNOG" id="ENOG502SJGM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265323at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031985">
        <property type="term" value="C:Golgi cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000301">
        <property type="term" value="P:retrograde transport, vesicle recycling within Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019177">
        <property type="entry name" value="Golgin_subfamily_A_member_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13815:SF7">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13815">
        <property type="entry name" value="GOLGIN-84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="584"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="261"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="407"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN98212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="627" mass="66494" checksum="A46C0AB11A03320E" modified="2014-11-26" version="1">MFTRVGALLEAIDKKTEELANAADERDLALAAEQQPQRLLSSSGVNSVASLQHHTQPALHFARGNDGSSFGESRLGGLARGSSNAVGNSGGACPTAGPNPLAMTSSTHLASHEACAVGHVPLSLPTKLPSFRPSQQDTATDGGGGGTAAGWKQHLTLPTAAGTFAGSSVVSSQGDVANVPSTTLGGGKPAIHHGSTADATVEQFEERCKALQADKMRLQQEAATHRAQCSAARDVLWKAEQDIRASRAAQRAAEQALTVYKETSQRLLDEAQQEVRRARDAAAGKSSATGLQQQTDVSHDAQELHQRLELLKTDHVSLNAELEHYRQEAAKATAELQHVQERHRQAQMSIDTLQLEVGAARELLEGEVAAHAETRSALRRLQAQKDEQIRSGSSPFVSGAVAQSTGKADSAAEVAQLRSELNELKQRHQILTIQASNRQAALDAAAREAADMKVRYNELAKQVNDVEVEMAAGFRTSSMYGDGNGYSAAFPAPPTASSMRGHRVFGLGAGGSGGHSADAGAPRAHSAGTVATTLESSDDARHRNPAMVRLARQYGIAGRVAVTVVCSIDSTAMQVGRFLTQAGWMWRVTLMCYIGLLQVWVILTIIGTLALENNVYVLEPPRAPHPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQB4</accession>
    <name>A0A088RQB4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_205640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN98055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698762.1">
        <property type="nucleotide sequence ID" value="XM_010700460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQB4"/>
    <dbReference type="GeneID" id="22574776"/>
    <dbReference type="KEGG" id="lpan:LPMP_205640"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200063600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_205640"/>
    <dbReference type="eggNOG" id="ENOG502SKD4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277477at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="26868" checksum="569239380453266E" modified="2014-11-26" version="1">MPVVDVSVLSATRITGTSLRSSFCVYVRLQGQAIRTKLSNADRSGEVCFGERFRFQYHYETTNPVRNRLFVELWTKSLFSQSCVSVAWIEMGEQRFVRGEQLRVNLHGTFEGKSSTLTLVITPLDFGEHLSVAQQPIPVMYGMPVEGTPLELPSPYSSAAYTPNTCPTVLDPMSRQKHEGLQPQPQTFVPASLPPPLYSDLLLARQHQVSGGANGQGLGALPAPSQNAKRDHNVDHSKKSQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQJ9</accession>
    <name>A0A088RQJ9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_221090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699109.1">
        <property type="nucleotide sequence ID" value="XM_010700807.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22575155"/>
    <dbReference type="KEGG" id="lpan:LPMP_221090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220014300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_221090"/>
    <dbReference type="eggNOG" id="ENOG502S21X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4869960at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45333:SF1">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_625, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45333">
        <property type="entry name" value="MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="741"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="212"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="431"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="486"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="593"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1067"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1283"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1438"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="261"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="332"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="374"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="432"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="486"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="593"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1080"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1292"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1449"/>
            <end position="1459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1459" mass="152865" checksum="607561AE0E76C922" modified="2014-11-26" version="1">MHGNTLSAAASPQPLPSPTEVTRVRAWRAEARLRTVLRHVSALRGAQQQGGGAHVSRLHDPVDGTAGAALTVPRTSSSTHPHPNTAPAVVAAAAASSPPPWPLLLEYPLAPLAQRVEQKKARDATRQQRRDARQAAAVAAAPTMTTASATAADMVRNALSQPLGLVAARFLSAAASGAPLLFPDMPLTSTIAADGHKSNCLASLPSLPAPLPTALPSSSSSSWPPPAAPGVRTPPPSTIVSPSPPNRTPKTPNQSFPPGVRHPRSLYRHSHHRHQRLPSNRSASRYSWDSADGSPSPLALLLQTPPSGSRSQGLLHRHHASARHPVQEDRHCHHHHHYHHPQRRYGAHEAVGGAPAPPQSTATNAMSKEKQMRSSVGHQGSTPTTKTPHPAGVFGKSSINFLARTLREAGTAALGASPLANSEKRHITAADHHHHACHYHRSRRREKLEQGNNGASGSSLYAADGCVSHDSCSSCNSSCACSGSSYDSWRSNESSWSTSSLRTSFTDGVRSPPSEPFTPLTIPRDGRYDPHAPLLPLMRCYGDTPTREVFCRVPSTSTQHTESRSSTPMSSEWFVESSSTGTTVAGAAVDTAAHAHDGRGEPAERQRQRQQHLERHHLQHSAPFSSATSTQLSYMSEMDAIERGVVAPYMSYLFSPEARVIDLRQLESRMGLSDPAPRLEATCIGFSRAADVYLVGTSSGLLWRVPVGGDSETLLATPLGSLWPPHAPTSASSATTAPAPLPGHTAAILSIAFNDDSALFATTGMDGCVIVWNASTSAKLRRISTVWASSTSPSSTVASQHAPNLVRFMPQNNNYLLVSYLGSSELHLYNSSTGLPVTNVAGAGVARTAASAIKVHRKSDVRSRGSGGADAGSAASSEAITALAVDPVASPLFFSGDASGTIGLWTYRAGDVVTRTTLRATATASSTALAGSGAGKHARTSSSVVDPLLHGTRSRVGSNGDDMAAFSTSLYQLPELRRVTALALPEQMGGIAALVVSTLHISQLHSLFRRCGPRQGAASAQSTSNGGAVSARPALRHPLESTAQVFRAVAQQNRACWAAAGSVARNQHDTHGRSGSQLQSAVHSAAAAPTAVAPTSGDNSSFVHVRAGWSSRLSETFSALWRGSGVAPSSGAHSSVAPAAHEGKFAMAAAKGPASTAGAAEPVTAPSEGDLLRQLRDDALDAVCPLLVLVTLPCDTIYALGVLLQLQPGGRHSSAGGGGGGMVGAGTPTVSYRLYPLLKTTSLSRLRHLGVGAAQSPDNPRLIVIATPCEEGFVRVEPLLRLATPSPSEQRTPPTGGSATPTPGVGSLQPDITAAAAHDDGGRRSHSHVLAMLPMPYGGRCTGVTWSPNGRFLVAITAEGVIYQWARVYLLDLSSPSTNAVATAARTAFSEEDAWQESLYRELERQQRVQATLKLVAQAGAGDKNDAVRSSGYWLEDDDATNSAVTGDSLGGEGTESYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RR73</accession>
    <name>A0A088RR73_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_230260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699185.1">
        <property type="nucleotide sequence ID" value="XM_010700883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RR73"/>
    <dbReference type="GeneID" id="22575230"/>
    <dbReference type="KEGG" id="lpan:LPMP_230260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230008000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_230260"/>
    <dbReference type="eggNOG" id="ENOG502SBXS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264675at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="21567" checksum="73AB45E091683372" modified="2014-11-26" version="1">MTSQVCHSWRRSIYLWLTTSSRSRYNRTDDVGTFLQAARRERNKVQSINDLFHTCGRRHHHCDTLEGIILQGRGEGLAWSFMMIPACFTLTFIASITLYRWGDRLAVQKHTQEEWQRCLLEASQNRAAADEELQSVHQRAVEMRAALRPLPAEQQWSAQLESSMLFINEKLQRHSRDAEPPRGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RR83</accession>
    <name>A0A088RR83_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Membrane magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_202000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698401.1">
        <property type="nucleotide sequence ID" value="XM_010700099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RR83"/>
    <dbReference type="GeneID" id="22574409"/>
    <dbReference type="KEGG" id="lpan:LPMP_202000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200025400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_202000"/>
    <dbReference type="eggNOG" id="ENOG502S7ZX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269728at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="14950" checksum="183D7C8C7D36D8CB" modified="2014-11-26" version="1">MAAMDYLFYAGLLLLTHAVYMAYSIREQLQVAQHSRSYIPATNLEGHSVFPTAMMVPITIEVLAGMLLGIAGFAHRHKMQDARLCDVTKYLRYDNQMNSGVGFIHFNHRGTVACRKDELQDDSKSLLQKKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRQ7</accession>
    <name>A0A088RRQ7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein kinase, putative</fullName>
            <ecNumber evidence="11">2.7.11.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_241700</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.17" evidence="11"/>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699509.1">
        <property type="nucleotide sequence ID" value="XM_010701207.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22575579"/>
    <dbReference type="KEGG" id="lpan:LPMP_241700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240024300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_241700"/>
    <dbReference type="eggNOG" id="KOG0585">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calcium/calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14008">
        <property type="entry name" value="STKc_LKB1_CaMKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF77">
        <property type="entry name" value="SERINE THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="580"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="116"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="201"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="907"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="917"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="609"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN98802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1431" mass="155227" checksum="4BDE6E04AA22BA3C" modified="2014-11-26" version="1">MGCSGSTQASRETGKDAPPKRYFDSTSRSSNQVVLDHTNSSKVNTNGVCTVDSKNPNRIRCSNDTEDRVHDRAIGVLHYPNPLSKVGASSDVDEGVVVSPLTEKSTRTRLTFPRHSLVSTDSHAEAGGLDEKEPTSTTASPSSLVVMQRRMSEGGRGRHLSPITIATIPPDSKQTQLLLTQAAVSPQGAATTIARVSISSPKRLRYAKPSSSGPSASTSGTAAPPSQERHQIQTPDISDGGFGIESDKEKNTPRDCGIQLSMTMVPGHSGVSHGTMVPLGSFCIGVRLGQRSASPKGISLSHKHSQSTVSLLSLADTPNNPHALSSGSDFGRDILGGSPVFTGLTTGEAGSSRPQNDYAMGRAIHAERLDQQRCNNGLAVFCNQPRECALCRNATVSFACEVCDDFFLCEDCRFDLKAVRAVHNPAHAMLSIQDNHCSSSRTFGGDSIFSLSGDGGVSCLFYHPCTKCKRSIDDAEPVYRCDQCDYILCQECFIQQQEPEDAVERASSLSAAMAATGEEHGSCKPLPFESAALVLVSGPALPHEHELKRFQRKSRSNSAHEGALVTKTRNSGGNKVINDYVVVRQLGHGSYAKVKLVQHIHTRELFALKILRRQKKAAQSGINLGRSRFKAAMAGMNEDDLLREIAVMKFIDHPNVTKLKEVIEDVDSQKVYIIMEYCEKGPIHAPGAPALPLEQVRQYGADILRGLLHLHSEFLYHRDIKPANCLVDRDGVVKIADFGTCNSQIRTKLAEGTPAFSCPEQVRGEEVSGEVVDSWAFALTVCEMACGTLPVSTTSFVQHRSLLMGKGPVAVPETGDERLHNLLTQMLEKDLSKRLLLPAAARHPFFAASGENAVVQQQQHQNQQQLSSLAELYDKALDSVHRGKHLKDCFYGVRALRRVRRKEVETVRHTGIDEQTSGGGGGGGSGAVQGEPYDVKSGDTYGASDGSGSDGEDEECAGRHLVGCRAGHEEAAAVVEEFVEHQLFSQDPKLELTYVTLTAPATLEKLNRLHQVTGELQLSHNALVCLAPLRLSTFSLLTEIIVTFNRLETFPNEVLVAPRLVRLDLSHNRIDAIPGSLVTRAPFLERMSLHHNAITSVGTTIVNVAESTPVKLRTPTRATTMPPGSTIVAVPGSAVVSSPVCSTSLCGRRGSSHREVVSVLAAPCLRHVRLSGNPLERLPEALETTHRLQLVLDAIPTLMEEWDAHMQTEKRAATSTAEIAKGTKSRLPAVIVWDDSFPVRIPNVEPAVWLAANNMAIYRVQTLRVCKTRRVVLCQCADPRFPNGLFRSEELEVYFTALAKALQERREQRQQLATEAPFSFSPPAELIPSEALPPIVGKAACRYVESYFFVTDDENEEEGGYHSLVSYLYDSLSANIPVLVVVVSSSTSSAVRTNIVAAISTCLTRLRGGDPDQLDAEQAELIVGTMRSLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRY6</accession>
    <name>A0A088RRY6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclophilin 15, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">CYP15</name>
        <name evidence="1" type="ORF">LPMP_205120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN98004.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698711.1">
        <property type="nucleotide sequence ID" value="XM_010700409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRY6"/>
    <dbReference type="GeneID" id="22574724"/>
    <dbReference type="KEGG" id="lpan:LPMP_205120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200057900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_205120"/>
    <dbReference type="eggNOG" id="ENOG502S0NR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="248132at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98004.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="499" mass="53694" checksum="C0552775BB2214A4" modified="2026-01-28" version="2">MTTCVSVHMWTAVSNRRDVLLPPPPPPAPHFLLSALTRIHGLPLATRTPPNIANTTDTTPCRIPPSAMQVELSLLFPHTLKELPVSFFIPLLAQRPRTVANLFFMCSGQLPLPAELLAAVHLTESEVAYTTTDNAKAAGLLPLSNSAVVRIDKTSVIEIGSSTTKSIFGGFIPDEPVTLPADTAARGQSIATTMSSLKAGTLLYGNLGMPNTQACRYYILLESVTTPEQRREFAGFAPLGMVTSGLAELKRAASQTAVQPCTLMPKKKVVVSECRLQLDYAKLTSSSEAGASALPLGGPREGTSQNVGKRQPTNPHERVAGRVRRRDDDDEDEQTDARTAVESDDGNTSGPDAAPLHSTGFFRMSARFPRAVLASATGSPLKRRRAEAFVVGDDGMPALRTTAIAPGEQVNSDGTAAPFEFFKAQQDAFMNDIDCIKDAQRQRLNCKAGKKKKSQQAFASSSSRGWHASSQKHRNSGTRATGSRAPSKSNAKKMVPWRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RS57</accession>
    <name>A0A088RS57_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">separase</fullName>
            <ecNumber evidence="2">3.4.22.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_205780</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>All bonds known to be hydrolyzed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by a hydroxy-amino-acid residue, the phosphorylation of which enhances cleavage.</text>
            <dbReference type="EC" id="3.4.22.49"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.22.49" evidence="2"/>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN98069.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698776.1">
        <property type="nucleotide sequence ID" value="XM_010700474.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22574790"/>
    <dbReference type="KEGG" id="lpan:LPMP_205780"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200065100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_205780"/>
    <dbReference type="eggNOG" id="KOG1849">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10255632at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051307">
        <property type="term" value="P:meiotic chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005314">
        <property type="entry name" value="Peptidase_C50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030397">
        <property type="entry name" value="SEPARIN_core_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792">
        <property type="entry name" value="EXTRA SPINDLE POLES 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792:SF0">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03568">
        <property type="entry name" value="Separin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51700">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN98069.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1281" mass="138941" checksum="D2B93D27AAE35633" modified="2026-01-28" version="2">MTSPYSSLLRTLHYATSRTLHNLDEVAALVEAAEKLSSSRYHRLASPWDLPKLLSSALRTQLNTRMCSSAAVASSVSTVSLCRVLATAWRLCPLVTLPLPSAADDDISPASVASLLSLTDEDVVRVGRELASLANAPGSSDAAESPACGTAIAVVTSLLLYWHVLSSEAQEATAKGEEMFRRVSTTVWRCLQQWTTANGCNEVRRRLLTTWVNTVLRRALQCTSGLCVVSAVTLLDTVAQSRTDLTMSMTFTSSGLSNSGLSEPWVRLHLRVCQYVMEDMRTHQAAFSTEWSRSVAPVLTRAFAQEPSLLSPSFSNVVQFAEPLDTSLGELMRVVHRVRRCALSSSAAAQAGEHASWVSANTLEPLLCLATLSQRLAATGVPVASFTTAETYRTCVAPLIAVSLRWGLVAEACALLDWFTDALDDRGTQWQRRLHQILDGITQDAASSAPAATLTGSREREGGLPYIKCLEELQCTSSTALDVLATSHDIRQLRPVCDALLRHHPSEWATEVLQDSFASFFVLGGLTRLIDALLQARDAPLARFYVTLLGRLLPRCACPTQLEALLRLVHRLATVLTTTHLSAADYAAPGSRYGTALAGWRHLKITLEHVCAELFDCDDVGGAGHLGWPQQSTAGLAWDARKRLQGFCGHSITLSGVESADAAASAQVMPNFPAVTLGTLVELCYAPAGSQSEKEGQLWLRRTRVSTTCSSGAQHTQDQQLPNLMVRCPVGEALQACAAEMADVMSQNRAQLVRGIASAVGETGRCLDNQSSCELATGTSCRWKQAGNCAAAPTETNAQRQQRLKEAWWCERFELDSRIGRVAVSMQDALGAAHMLLLGDPSPSLSGQLQALAVRFASECMRLRGDSRCPPVDAMQRVTLQVFVAAPYLWRDKTQSRGKITCWYGPRNARSCVCCTQTVKRAQRTLLEAVTSLGQLVVTATAAAAESSSSYALASEPGRLEECWLGLLVDKAVQCVVEEMVPAVLDAYYRELMPDAATTAPSDGGECHHHHANLLLVSREHVYVVLDGELHALPWEALDVCQERSMSRVPSCDYLKFYSTDSSAVSLRRSFVYRDDEALQHSSSRLTDLIAKHSHWEVAYGETLQAAAAAARSDGNTIASPLMHRLLSQSKASSDRIDTFVYAGHKGGEHLVPRSALYDWIPAAAGVPPVLVLLMGCSSARMQASALYDCFGLPFAYLSAGVSCVLGCLWDVTDADIDRLTCRFLQVASQTMEDGKCITIGECLAVARRACKLHYLTSMATVFYGVNCYVEATREDNRASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSY7</accession>
    <name>A0A088RSY7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">KIF-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_252200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KIF-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699790.1">
        <property type="nucleotide sequence ID" value="XM_010701488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSY7"/>
    <dbReference type="GeneID" id="22575868"/>
    <dbReference type="KEGG" id="lpan:LPMP_252200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250024200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_252200"/>
    <dbReference type="eggNOG" id="ENOG502QPZT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="409897at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022083">
        <property type="entry name" value="KBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46321:SF1">
        <property type="entry name" value="KIF-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46321">
        <property type="entry name" value="KIF1-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12309">
        <property type="entry name" value="KBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN99083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="601" mass="69108" checksum="8C24F35672DD6C03" modified="2014-11-26" version="1">MDPLNFHTTLEAIKILNASEGPASNIFEPKFEARRQAVQLRETIVNVYRAEASPRALEQLCQCLVFIGIAMMEVEEEKEGYEEVRRAYQVMQWRAAAVLPSSDEVCKVQAVEQDAILNSTSVTCSMTASSGYAGCVEYMAVHNALGLYLSKVDLSKAKTVLDRSEALYDEWAAWWEGQPVHCSITEVPLSEDGTLRTGEIAADRVAPTLLRFYMDSSYTATLFFMAQLHTTQQNTTTASQYCHRTMYYQLLNKQEFNRKSWATNALQLSGFYSSHFAYDKAFHCLVAGETLMPVSEDPEDAKGLVAWAFGRFYLHRLHHYGGLLTGREPGNENNDVVAQLEKSWRDFPGMPPLQTQPPIITFDEARTCFKEGIKRLQEAQACRPFESFCTEHIDIARDMVQLYAALQLFEPNRARRIAMTQHQVHLLEEFPDQLSFNAYPVVVRQLLYDLGSLYEDQMRMRVQQRKQPEPDEKPLKDKAFNAVVRKTLGYYERFCETWRHPTTHVLPDVLEEESRLPFFRALMRRAQVQLSYIHRTPKEEYDSIGVSCKAYNRAIEFYDKNPLSKELDAEVSKEVELAREMLKLLPAKQHNLWIAFQRNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RT68</accession>
    <name>A0A088RT68_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_252370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699807.1">
        <property type="nucleotide sequence ID" value="XM_010701505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RT68"/>
    <dbReference type="GeneID" id="22575885"/>
    <dbReference type="KEGG" id="lpan:LPMP_252370"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250025800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_252370"/>
    <dbReference type="eggNOG" id="ENOG502R74H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275850at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="450" mass="51411" checksum="4A0D0054B7ECE684" modified="2014-11-26" version="1">MLAIYRHSFPKRLRFDRASQLLYAQCYSINKRYRGRKYIPRKVIRDVLDSYVPMPGAPWLQLPIVRHVLLIRLINGIRGLQGGKSWLYNRSVEEEHRKIAEWLGKAAKTFPAHRGTFAAHASTSARQGSAAAQAMLEAMVEREEFEREVLRNFHVATMYQRAMRLGFLLVVVLCCLVYSSLHTDNLVYWYFRYWRRYRRREIMEYFRGITLLHTVAEVPPAYAGLLPPPCVRYNDAAGDACYAVNMVEMVLPQHSVTVIVIPCPQAGERVFFAQVGSIAEVCDGIIMEGVSFDKIDKLVPAAFFPLKSNTFPALGLHHRFLDILRNSSAEPPMLYPAGADVGWGATIMQAVIPYELRCIYNPTELSATKGEARIGWGHVRQVVEEMIADAAAQGGGEKRVLCLPWTLNQIVNIEASLVKYGFKVRNVYRLHWQREDHIGEHFCDYFSIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RT76</accession>
    <name>A0A088RT76_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_230070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699166.1">
        <property type="nucleotide sequence ID" value="XM_010700864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RT76"/>
    <dbReference type="GeneID" id="22575211"/>
    <dbReference type="KEGG" id="lpan:LPMP_230070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230005500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_230070"/>
    <dbReference type="eggNOG" id="ENOG502S7P9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="260795at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="173" mass="19889" checksum="F6F759D6C8F121CD" modified="2014-11-26" version="1">MLRCVSRSLWYQFKDLKSKTILEKLRNRKLQQGVHPSDLDMEELAKESGIAPPSSVSVQDFMHEKEAVLEMLQEQRLRRIARREAFLEWQAGQREKGAAHRLVRQSRKAEKYKRRHYHATSGRMLPLSVSPGEALPERHTTTSVPKACVSSTEFLRGGSAEKYHAIHLSLGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RT85</accession>
    <name>A0A088RT85_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aminopeptidase P1, putative</fullName>
            <ecNumber evidence="1">3.4.11.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_252530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.11.9" evidence="1"/>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99115.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699822.1">
        <property type="nucleotide sequence ID" value="XM_010701520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RT85"/>
    <dbReference type="GeneID" id="22575901"/>
    <dbReference type="KEGG" id="lpan:LPMP_252530"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250027700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_252530"/>
    <dbReference type="eggNOG" id="KOG2413">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9995434at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF6">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99115.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="601" mass="67198" checksum="20E2E1FD8148D3E5" modified="2026-01-28" version="2">MPAAVSGATMLHAVREKMKEATVAALIVPNTDAHNSEYVATHLQSRAYVSHFRGSAGTALITMDKALLWTDGRYWLAAEEEKYPEFDLMKQGMPDVESLEEWIAVNLGSTAAVGMSPYVATVAEWERLSKKINLCSVENIVQDMMPPETTVRKLYLRPAEFCGATCQERRAAILEEVEKQHCDLIILSALDEIAWLTNLRGGDVDHNPVFYAYAVIDKHRAKVCLYVNLDKVTDAVRHACEDHIEFCPYEQFDADLKKLPQGRKALVDERQTSEAVFRILKHVGIETVRVVCGPAQKLKGIKNAVELKGFRDCHVRDGAALTRYLAWLHDQVANKGVTDLNEYDVATKLEEFRAQEEHFVQLSFASISSIGPNGAMCHYHPAETGSAILRKDQLYLIDSGAQYWDGTTDVTRTVCFTPPSDEQREAYTLVLKGHIALNSIVFPKGTSGVRLDTLARMALWSVGLDYAHGTGHGVGSFLNVHEGPHGIGIHPVATEAKIELHSIVSNEPGYYKDGHYGIRIENLEEVVECRTKYSPTGFYTMSHLTMVPLCRDLIDMSLLTEMERAWVDRYHAKVVANIMPHLQKAGDQNAIEYLKYHAQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTC4</accession>
    <name>A0A088RTC4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_261150</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699935.1">
        <property type="nucleotide sequence ID" value="XM_010701633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTC4"/>
    <dbReference type="GeneID" id="22576018"/>
    <dbReference type="KEGG" id="lpan:LPMP_261150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260016400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_261150"/>
    <dbReference type="eggNOG" id="ENOG502SB2N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="144"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="27"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="351"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN99228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="469" mass="50577" checksum="5CD464C862260B71" modified="2014-11-26" version="1">MLLHEALLCTECPICLQPLDCRIRPPPSRPASPPILVTPARVTTDNSEATSTTSPSGSSPHSPLQLDGLTTLGEANEFRITFAPGVYGIDAADPWHPSLATPSPASPHELSSSLDQRSFALSGASLSGSGHAADSSSVEGTTGVVVLPCGHLLHYLCAMQLCEYATHPSCPVCRLKLASDADLILFRPQLRASSIVAAQAPVGISFSCTSAITTRKRRRSEEAERVEHCTQCADSHRTDDNANSGQVFSPESASQRVCAPSPAVVHTLASKSGGERSATTRILKDVLALTDTCATPKTLISPGTSRQEIGSDVDASQEEDDITIVGARQLPPSQAYAELLLRTTATWTERAETLKTRVEHLERSQQQLQSDCSELERTLTVARRRRELLLTSSSPKDEQDTFRSAQRLRELRRLSLETRTAMLTSTAQLAEAIRDHAEVRRQTEKYMRKLSRLDCEKGDGGTGASSSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTG6</accession>
    <name>A0A088RTG6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Membrane-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_230990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699256.1">
        <property type="nucleotide sequence ID" value="XM_010700954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTG6"/>
    <dbReference type="GeneID" id="22575304"/>
    <dbReference type="KEGG" id="lpan:LPMP_230990"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230016500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_230990"/>
    <dbReference type="eggNOG" id="ENOG502SJKA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267601at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839106" description="Membrane-associated protein" evidence="3">
        <location>
            <begin position="40"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="326"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN98549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="416" mass="44405" checksum="CDCE540F32F7CFB5" modified="2014-11-26" version="1">MPTAGVFKRFYSRTALLLLLLSPLTIIFFPSSPPGVTYAYTVQPPAMETPPSGSMLFWTEMLNLMATTPTKNNATVKVLSPNLPSKQHSDAEVNTGITSAEVSAMLLKYPHLVLPDGLTSTAVATKMDSAYSFNRKTTVRRFGSQPPLGNGRELRPRSMQLITALFHNTGAGEAGADIFIANATYMVQLLLSGEPAKWTISLSTSSSVILSLIVQAIAVLTSSRTKVCTPMVDSMVVLQADPQRKVIGDGNGGLLVDVSVNCGVTSVMTSRLLDIVEYNSMLLFLNTANITLAFQNSSRSLSTVEVTATAIRTTGNAAICDKACQGMIAMACVLVTLIAISVTITLTAVCCPCFCLHVYDGNSAKKSTTCESPTYNTSDTNAAEECNVRQGIEVRSREGSSHAPMSTSEEERGQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTH9</accession>
    <name>A0A088RTH9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mitotubule-associated protein Gb4, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_261910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99303.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700010.1">
        <property type="nucleotide sequence ID" value="XM_010701708.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22576094"/>
    <dbReference type="KEGG" id="lpan:LPMP_261910"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260023700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260023800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_261910"/>
    <dbReference type="eggNOG" id="KOG3595">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="260030at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009367">
        <property type="entry name" value="Elm1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056614">
        <property type="entry name" value="FAZ1_cons"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33986:SF15">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROTEIN ELM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33986">
        <property type="entry name" value="OS02G0535700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23398">
        <property type="entry name" value="FAZ1_cons"/>
        <property type="match status" value="20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99303.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2814" mass="318895" checksum="7393BB4C70B40899" modified="2026-01-28" version="2">MTSATVDDNALMHLSVGDFVAVVTHHMKDGKLHWTLGSVETPPYLRDVEIRLWEKQRLEYYDEDDTPANPESEELMKRIAQVKQDLQKSIDQSTDLTKQLRARRAAIMQRLREVDNYVAESKAAREAARDDVESIPDCYWQELKSYRMPPKMVLVIIRAVMLLLSEDDARTWLQMQRVLRDFDFKRRITSYDPNQQLSSKRRNYILQECVSKRSFRYDRAMQCSMAIGPIYYWVLAQLDSGEAQSQKDHVNRERIARQKELRGVLKQIAEQEKRIAEYQELMDDLDDQLRVCNQGNSNGSTVSRPHHRISANDRYAESLAACEGKEYLRPAFYAWKPTDRVIIVLRKNIVCNFGAVTSQGHEEEGYTMSHSQIEMLDAALMRHQQALEAMGEDDEEREDKALEEDMFKQSDSEAHSTLRSDEDILQERQRNATEATSKLQRKFEGKNWQRVLDRKRDAIEAAFTEESATCLMVPEYYISIDDLTVGSLLVDFSVQHDGQRTDAELQGCVKACGYPKVMSLYEEDDEDEEIGEGPEHQMKFGGDFWADITSEHRGEIEAAFLEDTSAATGAPQDEIVVHDIRADADEGLTVDYSMLSTGCNPEEVQKRVDAYAYPAVWGLYQRLAGLDGVGPIHHVRFCGERWADIMPGAEEAIKEAFIEDTADALGVAPQQVIPDEIRYENGLTASYAVTHCTLDGDEVDSKAEHYHYPSMWALYDRLVAAVVGAAYQKSFEGDGWETVLRAARPEVSEAFCIDTARAIKSAPCKVDLRSMDTDQNRLLVSYNVGDSQQRAGEVRESTRKYPYPEVWALYQMIMAEESKGTQNLTQTFDGEGWEAINERIPEQVREAFTEDVAVATRVDQACVTIHSINTRKMGMTVEYGLAREKGQSSYAMHKAAKDFDYPATWSLYEANKKSAPTRSIGKRASGILERCFEGEDWDIIVEGYPEELRDAFCSDAARVMGVSKHNVSIISAEIGSLIVKYQIVDPPCEDSEIAQRVEEDDFPEVMALYCRRMRGGDEGAAAKSPTVPELQNLEGMLPKMFDGDEWGFVMANHRARLEEAFVRDTADALGVSAEQVIVEEMTADVYMLRVEYRVLDCPSDKAAVQAAVEDYPYPFVWEMYPDEEDLGKYQRTFDGTAWEEVVASHENAVREAFAKDVADALNTDRHYVIVKSVRANAEGLVVRYNVMNEACYDGQVMDMRLKYGYPKTWALYGMEKEGGWVTTSHQVGFDGDDWVYVVQEKMPELQKAFVNCTAELFHIDAEHVTSTKYTVGSLIVDFELTHPAELSEEEIRKQLTACPYEPVWELYGYHPWDPTEVTETTHEVCFKGPGWATVLGSQRKELEECFRQGTATALEVELADVRIDSANCTKEFLFIHTTVTHHVFQDKELLQEQLSRYPYEEVWKLYVEDPGQGWTTTSHQVGFDGDDWEYILAVKRKSLEDAFRTCTCRSLELTDEHITNIVFETNEKALLTTFEVKHPKEQSEAGVNQKLAECDYMPVWELYIDHPYNPEELETTSHEIGFEGEEWNKVIETQPKQLEEAIMLDAADALDLTPNDITSIKTSFENGTVLIVRLNIQHPVLQDKELIQEQLGRYPHERVWALYEDAPLTPLSKENAAGFCRDAEGASGILERCFEGEDWDIIVEGCSEELRDAFCSDAARVMGVSKHNVSIISAEIGSLIVKYQIVDPPCEDSEIAQRVEEDDFPEVMALYCRRMRGGDESAAAKSPVVPEKEREMTTTLQDCGFEGTDWDYVWSIKQEAMCEAFAQGVADALGIRPADVQNINMEKSDDGIVLGASVTHPLVQDYQTIQKALKDHPFEELWVLYETRPYDPCEVVKTEHVIYFEGAKWGSVMESRGEEVVGAIRKDTASALKLLEDDVVSVCTKVESTGLVATVVVSHSPLQDDELIQEELIKCEYEHLWALYCPEDEAPHGTKHFDGLNWASVIANDKDSVMQAFRMDTATAIGVHPEDVDVNDIRTTDEGMDVDYTVNFANASEEDTEHILQAYPYPNVWDHYRVGEEEEREMTTTLQDCGFEGTDWDYVWSIKQEAMCEAFAQGVADALGIRPADVQNINMEKSDDGIVLGASVTHPLVQDYQTIQKALKDHPFEELWVLYETRPYDPCEVVKTEHVIYFEGAKWGSVMESRGEEVVGAIRKDTASALKLLEDDVVSVCTKVESTGLVATVVVSHSPLQDDELIQEELIKCEYEHLWALYCPEDEAPHGTKHFDGLNWASVIANDKDSVMQAFRMDTATAIGVHPEDVDVNDIRTTDEGMDVDYTVNFANASEEDTEHILQAYPYPNVWDHYRVGEEEEREMTTTLQDCGFEGTDWDYVWSIKQEAMCEAFAQGVADALGIRPADVQNINMEKSDDGIVLGASVTHPLVQDYQTIQKALKDHPFEELWVLYEMRPCVTNVLKSSLAGAGERESRELQRVFSGHDWDLVLKFCREEARDAFRKGVADSVNVVKSDVVVVDMRIGSLIVKYKVRGCNLDSEEINERVNAYDFPELMALYRARVRGGDEDEGEGSVSRSSAMQPEEVIPVDVADESEPPEGYKRVALSVNFEGELWVQIVKTHRRELAGAFRTDTAKSIGVTLEDIHIPECIVSAVSLLVHFSVLYAETATEEELRHKIDEYSYSDVWALYDDMAESLAAAVSEVMVKHFDGVNWGIVMEAYPTRVLEAFKEDTANVLQSDVSRVFVEDIALGSLVVRFRVRGLRMSLKRATLLVDNYAYPKVWALYIPREEANRSTSSCGTSENRSRHSRRRTEHLVSGEGVAPEDTVTYLRKALADARRERDMYMEQAEQAEMAQRASEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTM2</accession>
    <name>A0A088RTM2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 17">CDP-diacylglycerol--inositol 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="5 17">2.7.8.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">LPMP_262450</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a CDP-1,2-diacyl-sn-glycerol + myo-inositol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11580"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17 18">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.11" evidence="5 17"/>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700065.1">
        <property type="nucleotide sequence ID" value="XM_010701763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTM2"/>
    <dbReference type="GeneID" id="22576148"/>
    <dbReference type="KEGG" id="lpan:LPMP_262450"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260029300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_262450"/>
    <dbReference type="eggNOG" id="KOG3240">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251079at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003881">
        <property type="term" value="F:CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000003">
        <property type="entry name" value="CDP-diacylglycerol--inositol 3-phosphatidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014387">
        <property type="entry name" value="CDP_diag_ino_3_P_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF4">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--INOSITOL 3-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000848">
        <property type="entry name" value="CDP_diag_ino_3_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 17" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 17" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 17 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 17" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="16 17" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR000848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="AIN99358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="226" mass="25017" checksum="1D824F2DF329DDFE" modified="2014-11-26" version="1">MAPKPASPNPAKIFCFVPNIIGYFRIAASIAAYLVARDYPALCLLLYTVSFVLDAVDGKVARALDQCSHLGSILDMLTDRASTAGFLLVLDGVLQPMPYRYTCALAMLLFLDVGSHFCRMYASVFASKVSHKDVSDSIFWLLRVYYSKRHVMGVLCVGQEFAYIFLYAWASYASITELGSVCWCAFVVCAVPCFLKQVVNVQQLVDSLYHIACVDAQERCAQGKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RU45</accession>
    <name>A0A088RU45_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Dynein complex assembly factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_270580</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNAAF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700147.1">
        <property type="nucleotide sequence ID" value="XM_010701845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RU45"/>
    <dbReference type="GeneID" id="22576234"/>
    <dbReference type="KEGG" id="lpan:LPMP_270580"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270012600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_270580"/>
    <dbReference type="eggNOG" id="ENOG502QT97">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="538817at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070286">
        <property type="term" value="P:axonemal dynein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044458">
        <property type="term" value="P:motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039304">
        <property type="entry name" value="DNAAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028235">
        <property type="entry name" value="DNAAF3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027974">
        <property type="entry name" value="DUF4470"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22118">
        <property type="entry name" value="DYNEIN ASSEMBLY FACTOR 3, AXONEMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22118:SF14">
        <property type="entry name" value="DYNEIN AXONEMAL ASSEMBLY FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14737">
        <property type="entry name" value="DUF4470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14740">
        <property type="entry name" value="DUF4471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4470" evidence="6">
        <location>
            <begin position="135"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein assembly factor 3 C-terminal" evidence="7">
        <location>
            <begin position="254"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="46"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="101"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="46"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN99440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="593" mass="66403" checksum="7EEA50794AEDBD5C" modified="2014-11-26" version="1">MSDKYLRNEQQQLLNSIGTEVCWGWSPAIDFVSLLAKRPHRAAQQSISQSIKSQIGGQQSETPPSASSASVATAAPSSKSKEEAELDDLIAQIQGRRTATAKAAQSIPEELSESKPQCSPPFSSSTASPATAAAADDEVTVLLAGASDIRHLLRTLSSLRAAESANGKSGSQPTYHFYIYEPSLRLHCRHLFFLQWLLDSMFSLEELEERVLMFLDVYGNALMRDMTAAQVRNVVQRLRTALETDSSALLRIASFEEMKSKERDFVESQLAHWNRDASVADIREQWMQRVRQEMAERYDNRDNIIDWDFVFHLTEYTNLLKFPEYRTWRNTGVAFDVNHINPRRGFSYEYSVPNKTLCFFPRSGRGVYSGDIKNGPFFSFGALTPNAHIRHRTTDGTCKYGNGVVSMHNVRAWLYTLMTGLSWPWADHAFAWDDPRNYNYLPPGTPSGVAYTATLPKVRVHFVGLEWDRFMLHCKEGKVPRMDAAFFGASCTQYMTPTVLGDVMSRAVHAVVVAETAKFIVDAEDVAKTAYIAKLDDLARAGGWTREDALTSYLHDGKPDPLPVKGTMSDAQRVSQERYAQPSLLAYVAKASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUD7</accession>
    <name>A0A088RUD7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_280990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700439.1">
        <property type="nucleotide sequence ID" value="XM_010702137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUD7"/>
    <dbReference type="GeneID" id="22576544"/>
    <dbReference type="KEGG" id="lpan:LPMP_280990"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280015400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_280990"/>
    <dbReference type="eggNOG" id="ENOG502QW7Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="239319at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="189" mass="22307" checksum="44AB2CBC274745A1" modified="2014-11-26" version="1">MLSSCTALYARALVDRKSPKLWGAPGAPIIRMRGHHVTWKFQSYDIFVEHTHRRRNSDIRLLHYLGKHCPHPQKSLWSPDTPVTQDRHLFMLTTVDVDAFKYWFGVKRCRLSVGPWNILAKSGLLPPSYKQNSKLMPKPIFDKEHLMRYYLANRKDRWQMEREDYLSYKNSLVKSPEERAAERPVAPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUF3</accession>
    <name>A0A088RUF3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_281240</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Vacuole membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700464.1">
        <property type="nucleotide sequence ID" value="XM_010702162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUF3"/>
    <dbReference type="GeneID" id="22576569"/>
    <dbReference type="KEGG" id="lpan:LPMP_281240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280018400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_281240"/>
    <dbReference type="eggNOG" id="KOG0232">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1744869at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000001">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="10">
        <location>
            <begin position="49"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="10">
        <location>
            <begin position="128"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN99757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="201" mass="20362" checksum="91EACE84547CA2E6" modified="2014-11-26" version="1">MPLPGTQIFSAGCMLAVAVAAIAYGIEPANVDACIALMYPQSAGFFGAMGAACALVFANLGSAYGAAKSGVGVAYLGLTAPEKIMRGIVPVVMAGILGIYGLIIAVIINNNIHTEDTSYSSYAGYLHLGAGLAAGLAALGAGLSIGVVGDTAARAYGKQDQIFVAMVLMLIFSEALGLYGLIIALLMNNQANRYTDLCSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RV14</accession>
    <name>A0A088RV14_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_280920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700432.1">
        <property type="nucleotide sequence ID" value="XM_010702130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RV14"/>
    <dbReference type="GeneID" id="22576537"/>
    <dbReference type="KEGG" id="lpan:LPMP_280920"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280014700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_280920"/>
    <dbReference type="eggNOG" id="ENOG502SI0P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="263958at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="480" mass="49917" checksum="1131DD4E25E624BD" modified="2014-11-26" version="1">MDAIEVELSPGSAVKFTHAYAEHRVAGADEGTDCLSRDQYYSNYGNRPITLPKAFCASATSPSATVSTAADDLHEADTSSIPSPLLLEMQLDTILRGDCSSERGGSLAGCSCNSSSAVQQTALQDCMAESRVTKPSSSTMHSSTELTGEAASSPLHYCSTKPHHTGPGCTLSLRPPPLLSYVTCRSHTKTGSSAPRRVPLLSAAVPAPPVPFRVPGDASETRPPMSASPPCLPRGRRAAMQESIARFLNVEEAMASDTSSAVYSTSTSCSPICEPFVATVASAASPSLPRASAQENNKKLHAADLPLKTAAMGNRRPHMALFAPLPVNQTRTATSRAHASKATVSTTSPISCVGSVGNAQRDGCTTLVATSDVIAKAELTQLPSSSGESARKSAKFSLLPYTDSATLASFDAAAGMSAEGPLGVVEVRVYDKATVTVTCVACQLSINVFALLLAGTEMPDVCYCPLCGSRCKWTACTDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVE3</accession>
    <name>A0A088RVE3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_260950</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699916.1">
        <property type="nucleotide sequence ID" value="XM_010701614.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22575998"/>
    <dbReference type="KEGG" id="lpan:LPMP_260950"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260014200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_260950"/>
    <dbReference type="eggNOG" id="KOG1290">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2649at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001837">
        <property type="entry name" value="Protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000955">
        <property type="entry name" value="Protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="973"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="264"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="429"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="571"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="634"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="694"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="782"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="429"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="495"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="572"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="592"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="635"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="655"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="782"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="1010"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN99209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1407" mass="151532" checksum="679329FA103D9302" modified="2014-11-26" version="1">MQYASRVTPKQKQPDTSMGPDCAAGGNGGGTHRYPIHHNMHRGSSSSPRCLSPHCMELKKQQYFQPSPENQQQQHRRTLSSSNSGSPLMYVVSPATPDGSMNPCHRGYPPYRSHASTHSLLSDSASLISAMMEARTYASSPDLSVVGPTWSKRCAPSSLSLSPAVASRDLPLSQTHSPDLQYCRQRPLNSVTAADSYLSQIDLPSKEAPHMKTTSTLLGDTACGGWTSLNFNGGDTMARTPKQQSRGNCRNNLGCVMLPEEVSQPDKLTQSGMPTSSLPVHSRSAGTSRVRGDSPYQRASDEIPSRKQQSTPRRRGPANLTISVRTSSSAEVGGASPCSASTGGADGNTIAQQQHSENNSSALNSSVDKRLTTTAALVSHRHTPTSSVSWPRDAVVLSPFSRGATPSFHPHQRVVVEPPVESIPVMSPKTFSATIPTPRQAGDSTQDGVAADSASETRGSWASPPRPLAFAQHQHSEKGFIDSQSTGTPHQQPQPLHPPPPTPSSPKVLKSPAMFGVIDLSYSRADASGSKMTKSMSTGAAAIGANTVATTLTPARTSSRAPGVINARVPVSSLPSSSSNTSVISDHHADPTSAATSSSSTTATGTAAAQQHGRSPGSDFTARYGTAIVRMGHSTGRTDSSCSASHCTPSRSRDAATATAPTTAPTTPGYSPCRDTQTPVHTGTIMSQRGTLCAPLSLPPAKSDDDADKTEQQQQRHVVESQKRITSSAPKALVAARVRKSAAAFPIASVDTVRKSERPTQALMLTPDTVPSVAVPEDGARYSSSAATTATRSSSNSRVHPSFSRSLPRSTIAMIMTARKSDSAGAAASGTGRLERVRAVKSATSVPPRNVAAHERGPSEKLTATFPGRSAFAGNVAAQSSAFASTMNIGVLAGARGAHVRQHMNVSSAATSSVFSDVPGASPAFESFSFVSGRTQMQRYIDQWRDRYEEDKSAYKEGGYLTVIPGRIVHSRYVLIQKLGWGEFSTVWLGYDTKHATMGRGLSQAFVAVKIAKCRSSVQEATRYEVSLLRYLEARLPRHAAITNIIDCFDVRGEFGMHTCMVIPLCGPNLLSIIERMKADRSRRTADDLRMIKEIIVSVLISLHELSELNVVHTDIKPENVLCSAVDSKLVSSMEKFCSYNQERSHMISLVEFKESMAQQTTDRLVCLADFGLSALLEPPSSAPFWMSMCGNVDASLLAPLMRCKKNFPVTRSGVMDNQRGTLIQTREYRAPEVLLGLDFTCATDVWSVGCMTFELITGRFLMDPKRSSGPRDMDIEHLAMMMQLLGPLPPEITDIRVRNNDYYDAVVQGTPVPKSGLRPPPEYLHRFVDRNGNFIYASRYHSYPRRNLELELEPYLSFQEARLAASFILSCLHSYDPKQRPSAKKLLGHQWLHGVGVASKGKTSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RW25</accession>
    <name>A0A088RW25_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heat shock protein 20, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_292470</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700851.1">
        <property type="nucleotide sequence ID" value="XM_010702549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RW25"/>
    <dbReference type="GeneID" id="22577010"/>
    <dbReference type="KEGG" id="lpan:LPMP_292470"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290026800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_292470"/>
    <dbReference type="eggNOG" id="KOG0710">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="41"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO00194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="155" mass="17477" checksum="69634AAEC0522303" modified="2014-11-26" version="1">MWSPNNKRDSLSNSDDGLFPFLFPFPDLRPLQMFNTFFSSRSRGSWIPAVDLSQQDDGYTLVADLPEVKKEDLRVYTESASTICISGNRKSVLKQDESQLLVAERGFGRFERCFELPTSVDNSKIKATFNDHQLSVSIPKMRNTKSGASNSVTID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWB1</accession>
    <name>A0A088RWB1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc-finger protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_302300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00453.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701253.1">
        <property type="nucleotide sequence ID" value="XM_010702951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWB1"/>
    <dbReference type="GeneID" id="22577283"/>
    <dbReference type="KEGG" id="lpan:LPMP_302300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300027300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_302300"/>
    <dbReference type="eggNOG" id="ENOG502S4V4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267058at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051241">
        <property type="entry name" value="DZIP_RILPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21502:SF3">
        <property type="entry name" value="CILIUM ASSEMBLY PROTEIN DZIP1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21502">
        <property type="entry name" value="ZINC FINGER PROTEIN DZIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00453.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1175" mass="126610" checksum="8931E7BA8B848D81" modified="2026-01-28" version="2">MPFRFRLYNPPCDATSLSLVDTEALYNADGTSTRDIKEATIREMGWHPVQLPKDWFRSHQALDTTRQLLEAMQCTIQYLRHCRKSEERRAQQVTAQLRRCEEERAAAFEALIELRETVALYKQQSRDVGPVQQRARSPPSRATLSRERHMVRSRGTESTTRQQACSFCANVYPSWRALDSHIRKRHKRSEGCVAMSATSAPLSLEVQKQQEHPKATTRAPTLAHQTPSDSLFVGNAPPVLHEAGRKWDDCSLREEISELRMSMAKLIEQQAMLYRGLSPSYVAAVPQQSADEAATAAAVVASTGPLPDLQQHGSGSHEEEDILLRIQRDLLHTGTQLQQLQRAFESESAARGCGATDARDTLNLRDDLSHSEQRRQQLDSLKVPLGVRAVQELNPQNILHPPSLTESGHNAGAVRRRESVGDSLVIVSPITPLGAVTATSHHALGNQEGTTPALAQKHVRAATCTVSESLHSNLSGPCSPSETRRPTGAVGTTLPSPLSALGIHVSSGGGDSAAAAAAARRHENVTPQSTSHFPPSDSSVNAGNQSASREPETPTPLLPSSSFRGHLPWIEPDSATARIGTEDAVSANRYGSAPRVEATSWACGGLLLGAKLEVPEKRKAFSTSTRQDAMPSPNITAAGREVNSKSGLVTATSTGAPQRCDIMRSSEAISPGEACGRSSSTMQVLQVGVDTVHFAPSQLKVTQDKGQSGTHVPPREKPPPVTQTALTPAPNISGSVPSLGSTVADADRLQCLHAEAHGCIATGAGVAKRSSVGNVSESPPSRPRVPTVRVEESLVSTEQPACYSARKVIPVVHLVPEAPSELGNVLPQDPEKRRQEPMHGDALSPSAVSLPPMLGLDGHFQHRMLPEEPQRRGGNEDSRERKTDSKEAYSYSVEVQPLEALTQDDAVDGLFSTRFDATMEEGSNMRDDGLGGLVMEDVSNDELADAAPHAAEKVRSSQLSTFGDAGVDGKVEAHRVTSCSFPGPTEGGKQTPSQADSPPMESVSEGYSYYTYSYSYSDDKEEAIVASQETNAVEFCIDDVRQKNPQASSISEGAAVGRSGLPFRADVTPAAHDTEALKFGTVKAQRQDVRTASAERQKKSDQSVKGNARQPTSQQEAPSRRQRAPANVNRGGGQVSDEVATVPLRKFSSLFAPESQQVLKKPKGLFTRLFSKKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWN2</accession>
    <name>A0A088RWN2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small nuclear ribonucleoprotein E</fullName>
            <shortName evidence="9">snRNP-E</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Sm protein E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_301260</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701156.1">
        <property type="nucleotide sequence ID" value="XM_010702854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWN2"/>
    <dbReference type="GeneID" id="22577180"/>
    <dbReference type="KEGG" id="lpan:LPMP_301260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300017600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_301260"/>
    <dbReference type="eggNOG" id="KOG1774">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25620at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01718">
        <property type="entry name" value="Sm_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000083">
        <property type="entry name" value="Small nuclear ribonucleoprotein E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027078">
        <property type="entry name" value="snRNP-E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11193">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="17"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIO00356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="86" mass="9816" checksum="559EC2271C24D616" modified="2014-11-26" version="1">MSSHTRQMENPTGVVHRFMQSHQRVCVWLVHDSHTRLEGNLLGYDEFMNVVLGDTTETNLRNDKSYNLGKILLRSDNVGVIHPIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWT8</accession>
    <name>A0A088RWT8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_280600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700401.1">
        <property type="nucleotide sequence ID" value="XM_010702099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWT8"/>
    <dbReference type="GeneID" id="22576505"/>
    <dbReference type="KEGG" id="lpan:LPMP_280600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280011500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_280600"/>
    <dbReference type="eggNOG" id="ENOG502SHJH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273425at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="432"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="500"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="284"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="502"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="523" mass="55735" checksum="6CFDB97CB609357B" modified="2014-11-26" version="1">MPTTANFSASTPPAPSVPAAAPTLEENPSTPTHTSVNHIFEELCGSYVEKYMLHRNQIVHQIALQARNSINVQSMSVVKGQAAVTAAVSPSLAVPPELAREYARMKEEALAHSHRHNAPAEPSARGTEELEAENAYLRALVLRLEGQLQPPTSCEAQSDEIVSSLPSSCPAPGQDGVPATNHLRSPSAAPPDQLAKGSAALYNSLLSRSGSAASPPPVTSHQVSDLQEQIDLLREAVQELSQRASVRGGHSSSPVPADAAEASLRLRAISPFPRCATPTCTTDVRTLQRIILHQQQTIRTLEQEMEDVHTAKTQMERAMTQLREATASIAAREKGGTEDEDVGVLGATAHWRSTCQTEDRLSDCIPVAESTVYGYAGQDAVDSVCHDTASVAADGSTAAQEMHMMDVEAAAEQVAEKRRAATFGGMRPPLWFDSTTSVADPTRQPDVVAGEDECEDESSSGTLTPMPRRTVVLHQRFSSAIGDSFSVCGRISADESPFARHTQMSCGTASNRRTSAAGSFTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWW7</accession>
    <name>A0A088RWW7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine incorporator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_281060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TDE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700446.1">
        <property type="nucleotide sequence ID" value="XM_010702144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWW7"/>
    <dbReference type="GeneID" id="22576551"/>
    <dbReference type="KEGG" id="lpan:LPMP_281060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280016400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_281060"/>
    <dbReference type="eggNOG" id="KOG2592">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5963193at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005016">
        <property type="entry name" value="TDE1/TMS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383">
        <property type="entry name" value="SERINE INCORPORATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383:SF9">
        <property type="entry name" value="SERINE INCORPORATOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03348">
        <property type="entry name" value="Serinc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN99739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="416" mass="46410" checksum="9DD790929C115C12" modified="2014-11-26" version="1">MGDTEDGLLSRRRFHSADEERDLSPGLIVRLKYAMYLFVALLLSMMVRGLMSSLFDKIPWLEKGCAMSSKGGVIQAACGAEMLVYRVSFALTVFFGIHWLSVSDLTCCIRSSDRVELQRSFFTVKTVLLVLLFITTLFVPNGFFSVYAHLCLVCSGLYLLVNVIFLVDFAYQWSDDWSNRADDNPKWMWYLLAIAIGSFTLAIAVIVASFVIYVPHSNCNYNACAITSVVVGAFIYLILSIYVPHGSIVPSSIVFLYTSFILFFTLRTTDNEHCNRMATHSSSTTYSIVQTISTMVLTCFTLLYSVVAAGGSGTSLQIGQDDDGLAEDPEETGHLSHYMFFYTIMIFGSMYLAMLGSSWHVSGAGEDGLSKSINLAFWVRLTTVWAAMLLYIWSLVAPYTCCKGRDFGFAVEEDWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXV2</accession>
    <name>A0A088RXV2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-ketoacyl-CoA thiolase-like protein, putative</fullName>
            <ecNumber evidence="5">2.3.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_311560</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="5"/>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00746.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701546.1">
        <property type="nucleotide sequence ID" value="XM_010703244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXV2"/>
    <dbReference type="GeneID" id="22577582"/>
    <dbReference type="KEGG" id="lpan:LPMP_311560"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310021700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_311560"/>
    <dbReference type="eggNOG" id="KOG1392">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="241374at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050521">
        <property type="entry name" value="3-ketoacyl-CoA_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42689">
        <property type="entry name" value="ACETYL-COA ACYLTRANSFERASE FADA2 (3-KETOACYL-COA THIOLASE) (BETA-KETOTHIOLASE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42689:SF1">
        <property type="entry name" value="ACETYL-COA ACYLTRANSFERASE FADA2 (3-KETOACYL-COA THIOLASE) (BETA-KETOTHIOLASE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO00746.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="440" mass="47026" checksum="087D4D05EB8FFEE3" modified="2026-01-28" version="2">MHSTRHVLRQRAVLVTGVRTPFVKSFGALMKADTLQLASASVAGLLNKTSLDPNEIDHIVWGNVVLQGNAHNCAREIVIDLNLPKKITGNLTSMACASGLSSLAQACMLVEGGHADVVIAGGSDSVSNAEVPLPRSVTHGMMMAQKKGIMGFFKEAGYNPSKWFPSGVALTERSTGKTMGWHGDVIAELNNISRKDQEALAVTSHANAVLAERAGYFKDEVVPVTVDKGGRKTEVMRDDVLQRDTDKMKGKMPTLKPTFRKDKGTITAATSSTLTDGGSAMLVMSEEKAKKLGYQTDVSVKSCYFSGIDPYPQLLLAPVLGWGPALKRACLTPKDIDLYEIHEAFAAQVLATIKCLRSQEFFNRYASGSKPVLTEDIDRSKLNVNGGSLALGHPFAATGGRIVTSLANELRRSGKRHGLVSICAAGGLGGVAILEHTPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RY92</accession>
    <name>A0A088RY92_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_300200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701055.1">
        <property type="nucleotide sequence ID" value="XM_010702753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RY92"/>
    <dbReference type="GeneID" id="22577074"/>
    <dbReference type="KEGG" id="lpan:LPMP_300200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300007200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_300200"/>
    <dbReference type="eggNOG" id="ENOG502RY9Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271862at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="395"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="492" mass="54236" checksum="F83B74F3C589AC8D" modified="2014-11-26" version="1">MTKVLDVSRETSPSAPPHTESIYLLTSTSLSDVEFKDPATQSQALVGLPRVQSVDAVHRFCDTYAEALSRVHHVLLPGGVSPLQCWLIKKFLERVPQARLVCNRFGHALLTNAVFHDGVRRAVLENTPNTPSELLRFAELPEDRVSAVTDGDAVTISVTNAAAESSASVPVRALRVVAVKSKGQQQRRREHNQTHHPAHFTNELLFYYDDIFSALFVGHTLHRLPWLSTVLTEASRELLLPMPPPLAMQHPLSRPSPLLDTWRVSESCEDVVEALRRTPELERVLASSYGELCGSVEDCIAGLESSSDALERLRSRLARRLATDTSRDVHRWSTALLKRILQEVVCTQKASEPTSTEMQEAFLCWARTGGEWGRLATCLTHAAMMLPPSTDTEEAASASSSATDTGAAPFSVSGAGESGVPESLEGAHGVELLVAVFNRKGLHGLTRTVQRETIDVRVFLAMSEEDLKRVFKATFGITKRLELLQEELRRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYD9</accession>
    <name>A0A088RYD9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_320790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO00966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701766.1">
        <property type="nucleotide sequence ID" value="XM_010703464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYD9"/>
    <dbReference type="GeneID" id="22577820"/>
    <dbReference type="KEGG" id="lpan:LPMP_320790"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320012900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_320790"/>
    <dbReference type="eggNOG" id="ENOG502QQFE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1904536at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050576">
        <property type="entry name" value="Cilia_flagella_integrity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973:SF26">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN ODA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="557"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="557"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO00966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="594" mass="65312" checksum="48FB6128C78D33B5" modified="2014-11-26" version="1">MADMTNSVIVASCKANGGYAAPHLNDQLFLHCRGFTAIQNLEPYTDLKVLWLEQNALSELSGLTSQKDSLVSLFVQNNFIRSLSSLTTTLHGLRVLNVSHNYLTSLRGIAAGCPSLETLQASHNQLTSLEVCEELWQLAGSLTSVDLSFNRIEASREPAGSATANPVTTVATTTVRELEDTAAADDVRIVDAADTGAVLSAAMPPTVVALPKPDPLAIAQFFQHLPLVSVIYLQGNGLSHRLRHYRRNMILHLPALTYLDERPVFPEERRVVEAWGRCGDAGEASERAAIREEKRAHLTQCVTLLTEQREEQRVVRDRLTQELDLRCAQELEELKQRRRRDRDNRVAIDAEEGVARDAVEKAEQEARWDTEELFQEAHKLLSVTETAHRRAHEQRVAVAAAVQAAAQEAVAERKAEDGAGSGDADSDTAGVSTTAALKVLENAASHSSGGLSFTCCNSDATDTIATSPEAPLPPQFSALAELLRLDDDVLKEMEMEIENVLHDISSSALLAKPISAPQDAGSAELSDSPAIFSSRQVTDRTTLRMEKNVRAAVGRVSNQLRAQQQRRSSGMQQEEAWERFEEWKARRTSQQWKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYP6</accession>
    <name>A0A088RYP6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_323660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702048.1">
        <property type="nucleotide sequence ID" value="XM_010703746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYP6"/>
    <dbReference type="GeneID" id="22578107"/>
    <dbReference type="KEGG" id="lpan:LPMP_323660"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320043400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_323660"/>
    <dbReference type="eggNOG" id="ENOG502S1K3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272215at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="637" mass="67553" checksum="88F40099A918435E" modified="2014-11-26" version="1">MSAEKPKRLHAKRSFLEPLRVPQRRRSSKEEGESPASPAKSSAPKSAIEWLKFASHLLITSSGSGEAEERVLKVCEETAAMLLEEDAKNCTSTKSKAPMATAAKASGFSPEEGDGAVDGAEGNAVEDGIGAGTFAALEEEPPSAERLQAAYLLTAAAVAATEAHRLTAAESAVRLARAAVEAYRCPMTASTLAMACVRWGATSRDVNSRTTAFETALAVIDVASKELLERETLLEEEIGYMLRMAWMLVGIGASDNAHQQLTVVLKHNPKSYMGLLLLTLLHTVEGDYDSANNSVTHLLDAYPQDVVGIVVHAAVLQKCRLPESADGHGKGAAAAAELAIAMARIAVLSDEAASAEEAGLKKKSLKGLCTHCAPDEDVEGGPKHSSDELKRRVVGHWALLGHVATRLGCTTVAEVATEAGTAAITQSTMLCRRSFADLQCSQARLSLARLRERIAAQHIHHAGGLSVPLVRDINLLAILDFDTVASAGLARMVPGLPLTSSATENICGASLVSPDSGTQHLLPPKMFDAVASTLLAAVEAYPNHGEGHVLLGVTRLLEASQPDLPSDTRHNRLQEAGRHFVNSIQADAAMPEAYLGAGVVAEAQGAMDESFDFYTSAAEVSVRAPLISWQYFDYLYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYX8</accession>
    <name>A0A088RYX8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_322840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701969.1">
        <property type="nucleotide sequence ID" value="XM_010703667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYX8"/>
    <dbReference type="GeneID" id="22578025"/>
    <dbReference type="KEGG" id="lpan:LPMP_322840"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320034700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_322840"/>
    <dbReference type="eggNOG" id="ENOG502QWKU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272261at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="594"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1134" mass="123737" checksum="77BF9E046FDCC35F" modified="2014-11-26" version="1">MQAQVRLHRLLRRACTPGVLSSNQVGVTVHALRQLNLLDVSSHSPERSTLPIVRHLCSGADARSQANLLHALASAVSESHSCRTVVHQELHSTVQLVQAALLEVADTLTATETVLVMEALLKLMPYVGCDAGTPLVNSRLVEEVRERTMALASVVERPVDLLGVTRVVVEATSSTSAAARDGVYGGRPSVSNFAWASFSLEHILRVVQARLSTFSKQELISLVDVLTVRRSSVSSGDVSLPSPFSSSAPLTPFHHEKSRGAAASMEKHAETAADTTSATADGVMLLDASRPLIPDILACALTTVPSLSISQLCAWLTRLTTLRLTDNSLLLAVVQSLASADVQYFTIPQLTSGAGALANLLTLTSVPGQPWAHAELCIRLYARLLHCLSSALYDADRHDPEVVHHAQTRLLPLLGTIPEAALDDYLDSAMPKSMRRVDLGFGDKSKAAAPDTAVRPHFLSVCATLAGAIEKTAAVLLRSIAVLPPREQALVAAAVFYWRVYTPSVADMPGASTVAVAQQPSIPFEQECQFSLKCRDVLHRCSPLTLDDMARKHRALCGLIITCSAGFTARDSVYVLNELVVAHYTDRALQVLHQEEQQQQQPQHQRRLSSSAADLSSVPCTQPSLLVSVVRVTSEERQVLMKLLNDQLQGPLLSALGEVHTSQLVRYLSSLSRMGVGAKGPYRAVMRHLNGRSLSSFEQVSLMVVMARHHLRSRRVVHEVIRALPELGTALSTAAKVTLLKSLGQVNGQQFVKAPYDETLLPGKFFPTLEELPRLTFLQLVFCFNGLIELRQYENPAAQAVLVEISKRLCTPPLRPSDSLRTINSATALAEFLASLCRFGGPAEGVSTALLLETLQALEQRLATTRSLFVDLARLNWYWPCVQEYFHLSSALWNGCASSSHGARRDTTGPIVEQWSFTTDEWLRLTRAFGQLVGTAGARVAARLQDIAKSPSLRPNTFLWCQMVCGLRFGGIPPRGSAEEVRLVENLEQKKMLPLLSNPQQLLDMTVLALHFTSEGRDAEAMPALRFIQKNMAAMQVQDCLQVWWYISQLLSVSSLPTTATSLGCVTSPRRSEVDKVQGTGTNFSSAVVAPVSERARFVLQEVRDAAKEQVLRGEKAVTQKLSVMEKRLLKSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZ33</accession>
    <name>A0A088RZ33_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinteoplast poly(A) polymerase complex 1 subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_322810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701966.1">
        <property type="nucleotide sequence ID" value="XM_010703664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZ33"/>
    <dbReference type="GeneID" id="22578022"/>
    <dbReference type="KEGG" id="lpan:LPMP_322810"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320034400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_322810"/>
    <dbReference type="eggNOG" id="ENOG502RIGE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272773at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="785" mass="88724" checksum="2677D6E904E359CC" modified="2014-11-26" version="1">MLAELGGAGRTGAAMPHPSSPSRTAKSRKQRHQHHVRQVVGKDVAERAKSMTDVEWASVPMADKHAFTKYMGELLREHPTEATEQQRRRYFETTMVDPRNLDPARTVRDEYERLKMGLPVQLKHPQRSLGVSQAIFETGDASLFDPGKVDALEEAMTQVKQVFTDYVRQRREGVSTETTRRKLANMLADLNVETQRHLSHMFKYAEERVRHEAREERKRQLSELQRLRRLVSSSSRQRASPSFESSTPILTTDASVPEDAMCPLASSSEGVESSDAVHDVDSPTPARLAKMKRRAVLKRSLGKALGLEVEVVESLITELEAQEKFMQFCEVFARLTVSRGFRHGPEDECLDAYTESLRRLYSVDANKLSTLDVVQYLAAKEEAHPVDWAKRWYERLLRIPLEHTPEYRRLEAIRDGDSVALELQARAEREVEAPVSAGHEAARQAEREAAGGRTQQAVRLVEKMFMRPDDPRLKSLHERRLRYIAYLQMERQIAQSRENAKIFEGIEETTEAEECRRLYAQLMERKQRLAADSTAALLSEGDGSGSVDRSAAAASAAVGTDVAATADNVNVFAQDAEAAALFEQISRITHSVIRTHTQETRRRSKAAAKAEVLARVLRLAGLTNADGSRAGRAEELQRLLQEKKDKVAQRLLNVLEADVKSDLEWMDAMDEAERPPLLPIPEGMSYVSAADVQAWKEIRDADRALSADPFRKNKKQFQPRLFGQPWQLPDKPLLFWGTGTRAVQQALEHAASDAERRRRGEPLAPPYPCPENPWGWRLVKDILDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZM1</accession>
    <name>A0A088RZM1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CYP4</name>
        <name evidence="6" type="ORF">LPMP_331720</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702264.1">
        <property type="nucleotide sequence ID" value="XM_010703962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZM1"/>
    <dbReference type="GeneID" id="22578325"/>
    <dbReference type="KEGG" id="lpan:LPMP_331720"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330024100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_331720"/>
    <dbReference type="eggNOG" id="KOG0865">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097014">
        <property type="term" value="C:ciliary plasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000002">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF389">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="26"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO01464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="196" mass="21175" checksum="41C6D267F871C9C2" modified="2014-11-26" version="1">MLGRTLLCAQRKIPFYPVNPKNPLVFFDISIGSQPAGRVEMELFKDVVPKTAENFRALCTGEKGVGRSGKPLCFKGSRFHRVIPQFMCQGGDFTAGNGTGGESIYGHKFPDESFAGRAGKHFGPGTLSMANAGPNTNGSQFFICTAPTDWLDGKHVVFGQVTKGYDIITKVETYGSQSGATRQPITVTDCGEIKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZR9</accession>
    <name>A0A088RZR9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_311890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701580.1">
        <property type="nucleotide sequence ID" value="XM_010703278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZR9"/>
    <dbReference type="GeneID" id="22577615"/>
    <dbReference type="KEGG" id="lpan:LPMP_311890"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310025800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_311890"/>
    <dbReference type="eggNOG" id="KOG1471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1434354at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF1">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="134"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="500" mass="56358" checksum="87E28FEF408D3020" modified="2014-11-26" version="1">MVTSRYPVLTADQEKKVTELIKVMKEKYDPLPPLLLALQRYTPEVAGNASDDAAPGTFFSPIRNYCYRFLTSRRWDLQMAFEMMQLSVSYREENALDSRAELPSAVSCRGWDQEEVRAALDKPTRPTNQRLDRLSTGIAQYFTLGLHYWDKYGQPVVYLNLGSIDESGLLKKLEQLANVGQTPDLVMWELVQHLIGVQEQLLFYQQMQYTAGKLNAEADDGLIRSSTIVVDLHGLTFTMLRKAALDLFAKTLRTLFQYYPQCVHQILVVNSPAMVMFAYNIVRVAFSPAMHEKLRLISAADTPATMKDFIDAQFVPDYLGGLCHCEGGCIGGYDLHLKKMTKDDGSAKNNASSSAQSSDQNDEVDVTTEDITLRPGEELKRSFSLKKGESVVWEFASANGHDVAFTRYFVPEKEVPSIDTSTLPTTKLKSYVVFQGSLSEGLDKYTASDDGLFVIMWGNNNSWFTVKRLQLNVFKQAATLMRVEQAAEACENEKRAHIRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZS3</accession>
    <name>A0A088RZS3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mitogen-activated protein kinase, putative</fullName>
            <ecNumber evidence="6">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MPK15</name>
        <name evidence="6" type="ORF">LPMP_332180</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="6"/>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702309.1">
        <property type="nucleotide sequence ID" value="XM_010704007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZS3"/>
    <dbReference type="GeneID" id="22578371"/>
    <dbReference type="KEGG" id="lpan:LPMP_332180"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330029100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_332180"/>
    <dbReference type="eggNOG" id="KOG0660">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272152at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000966">
        <property type="entry name" value="Protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="8"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="443"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="503"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="617"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="914"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="456"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="510"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="934"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO01509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1016" mass="112673" checksum="6615F9E572D36701" modified="2014-11-26" version="1">MHLLAGRYILVQQIGKGGFGAVEEYTDAITNDNVAIKTIPSRYVNQESRRLVREIDIMSFLHEAHPHVIGYFSIFATKGAAIPNHNNSNGFDDPLMSVAQTAENTPFELNVLGDHYAGLNEDERLRLHHDELMAFVTRINKTDEFNVHIVMPLMKGDLFYFIRLLSSQSSVQRLGVTHQFLAQVAVVFAFQICFGLDYLHQCSIIHRDMKPDNVLVRLDITNPYMSTALIADMGLARDAQQSDTIYICTRYYRPPEVITSVSGGSPQIDIWSLGCIFYELCTSHTLFTMRTALNERGEWDGAKASLQLEVILNTIGTPSPEDIERYMPSGNAKLYLQRSAARPSQLRQLIEHNWILHTSDDEKEKWIDLITRCVAFFPEQRPTAQQLCQHQLFRKYNVFYGTNVKQYTPTPYTSSYSGSSESSRVENKAAILVLVQRALRKTMPPVNEESGDEELSSLSSGSSSISSGECGSASDNEAAHVTRQTTINDYLSVAGHCSSSMLCDSRQQHGESGQTEELGSTTESFSAFDSSRVSGAAAAPPPTRPPQQQQRYALPPFDNSTLKDYCKSLLNDDDEGDIGCNSEQVCDTDDEERLTGFQHQRPSAFMLHLSPGSIFRNSPASLPDGPTEAAAARAEPERRFTHSFSSEESGPVVEDTPPLELSPTFRDRITRRRSSTADEEEDPRLESQMPSVFDLDSYRVGKSLDAAMNEEPRISESVLPQTMESMPADEVARLLSAYNIPLEESNYRTGLSHVQSVPPSVMTSGPYNFISSCHVGGGVGAAMPPTQQPFNNETLPNEATRIPSMHVSRGGNEGHLHVDAKVGTWAAAPPGSTVPPGNGAAMEMDLHEQYDYFADTDYYIGPTPSNMAQVAAARQPAEKRDGSPYLLNLADNMPLEQAQQRELSEPLLPPIYMSTAPPSETSLFHQPPSPTPQAHRHQPPPHARYRQSVPGFPPIASEELRQRYMSYRHTPQSIQAATSSVLEELGGCTHDAERSGELRQLLNYYTSLQVTPLYTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S025</accession>
    <name>A0A088S025_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_320120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIM50 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO00900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701700.1">
        <property type="nucleotide sequence ID" value="XM_010703398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S025"/>
    <dbReference type="GeneID" id="22577753"/>
    <dbReference type="KEGG" id="lpan:LPMP_320120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320006000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_320120"/>
    <dbReference type="eggNOG" id="KOG1605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000317">
        <property type="entry name" value="NLI interacting factor-like phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="18"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="228" mass="26802" checksum="80AE4B26E5B00126" modified="2014-11-26" version="1">MTDGPPRFFTKPEEYVGVNKHRRTLFLDMDETLVHCYFEKPTFFIDTNENFFQFTLEDDPSVTYYAFRRPGLSEFLHQCAEHYDMRIFTAGEDLYARTLLRWLLPDNLIDESRWYTRDACVGDGYGRLIKNLSMIDGFQFEERTALILDDSAPDNVYPHQNALAIPRFAPQTGRTDEENYGRMQADRGLEMFGRMLCGDHFTRCDDVRVPIARFYALIRTYTQNSTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S091</accession>
    <name>A0A088S091_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ankyrin repeat protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_341870</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702613.1">
        <property type="nucleotide sequence ID" value="XM_010704311.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22578692"/>
    <dbReference type="KEGG" id="lpan:LPMP_341870"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340024700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_341870"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272079at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF74">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839154" evidence="6">
        <location>
            <begin position="27"/>
            <end position="3736"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="2104"/>
            <end position="2136"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="3469"/>
            <end position="3495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2433"/>
            <end position="2457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2660"/>
            <end position="2695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="3707"/>
            <end position="3736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2669"/>
            <end position="2689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="3725"/>
            <end position="3736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO01813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="3736" mass="402268" checksum="ED640841BA58AE81" modified="2014-11-26" version="1">MQAPSNFTPARAPILCLVCTATACGSQLIATINVTLDTTLAEVRAVLVSLATGGDGGPAAVKQAPINVSAQQAHTIVSSPLHPFNFTETFSFVHCGGCRAYARRKEASLHVEDVLPRYPRFGVPPASLPASEGLSSSTAVLGTVTPGSRGRVCSSSCTQWLPNAAPPLAVVAYPRQPKRHRHHHHHSPNQTEEEAMSKLDGAHMPQQKRYALAALFVTPGDSAEGGLCAERVVAERLQLQLPDPLRPLGAVASGAGLFSPATLAANYGRPFHVETWCSGVTRWNGNTEDFLGRTLLQEAAQVGNEAAVRYLVSQPYIVVDAVERQSGCTALQLAVLGNHVGVVKVLLEEGGANPLIPNHAGDTPLHVALENRRAVLVGLLCARLRALQVPPAALKEELMRNKIGYTPVELFHLYSPSLGDLCRDGASLLAVKSLVHHYFFFPDEVTARDAFSGQSVLHAAAAGSGVDVVRYIAEDLGLAASLSVPGGPYAELLCDYRRQTPLHVAAARGEPACMQYLLHNLPASCLMQPDVNGSTPLLLAMKARRWRVVELLLAQCPPGTLAAALQDRNGLSALHLACGLGMTRVAATLLQHHGAVATQSTIVGRPSSFTPSMGADVQWGPHWENIALVRHSALHGRLRKLEAREIKRQVQRQQRGTSAIGSLTESNGRRYCPLAEDADPVSAVKAAQQYPYGGARRGYTPLRCAILYAVHRGSGAATVPVDLLRLLCEYGALTAETAEDTRDLLFYLLTHRSDAAAAALLAWVTECCASAVAVLQRDNALLCRFCALGEAVGVRWCVEKQLCDVQSKYVNPLVACAAAGDAAAAAFLIQCAGADVNAIVGHESALAVALREGHDEVAQVLILNQAVLSSRDGSWTALQQATRSNLESVVRGLLGSRATDPLDVSRVLLRTLQGLLYAKPSRRREGSRVASYLARAYDPLISEVHPTELLHLSAAMGCFDVTLTLAERLQALPKTVWAELLATAPPPPSRPTTLIEPTLVPLTIKFPRLLPNRLTDRGGLYRPPNPFHRLVVPTVRRAVLVTLLHRVKARDVYSYAVEAGQIDLVYLLRCGLHLPPWPLRDVRGWTVTDYAMTRHSRSRASLVALFVAAGIAPATRHGRRMLHSSGDGSLVAAVHYAQQQRWKAAAALPHLAKAVSVAEEEEGHTGAHAAALALELVADTLSCLVEAPAERGVSDGGVAMVRYILDAFVEARHLSDFRHVPCAWLGRVVVACAAAGRLDVLRLLREHYSIDLAQNWSHSTSGSPPSVSGTHPTPLLMAVHQRHSDVVVYLLKAGCAVHERSCPSAAMATHISLKGIRTLLISPLCLAAWKRDYVLLRLLLAASPPLRPKDTEEEAGRSVGDVLRGLVLSARPGMQHEAEVALADCVRALATAGHPLRFAGTVRVAAAKGLVQVAQALVECYGSAALLADLAVSLDGGDAKADEDAEDTTTPRARGQLTALAYFAADTRLVPVLRSLLVERMVDEYRLESWRLTMLAATLQALCHKGGRRGARVTAAAVDYALWRGCAEGAVVLLALGLVGRGVAPAPRSSCAAGSTAAAVSAKAFSLCLRFARVLRLWHKRCRQYKSYTVLHSAAELGYGDVVGALTAEMMGLHLPVVDSDGSGSAFSSSNIRATVSAPSLYALAATHVDGWRWFPYFERVELVLDPRSLYIAARDMFALILSGFGVSQAVDRVCRRAAQHKLLGDVFSVFDSTGIPPAANTSLGHVNSSGALDAVTDIGDAPAATRGCAVSALFISRQLHLRPAVFFLAGGTYVLTSMTSLTCAIAAGSLEWVQYIVVHGPSLVYHRATATRLSTAADRRAAAKERHAQLQATGVVGRRRRPWHPCQGSTRRPRHRRHHCETGLAYGSNASAAPVLRTDAVCRMDALTLCMAMLAEVHLRRRGCVMAEAYEDILTHLLSWPAATPRKETINLLAIVAASLRRWSLLISIMQQADRLYEAGLMAGIDGPRQEAKCQSTPPRYLFPLLPEEIPAVLARVIGSARHIMHVVARWAPKDVLIEVARHCQRSDVEAAADARGCTSVYHALQHRQSLALETFAALRVPMSQPCRMRQCQTPLMVAAACGRASVVTALLRPERVNQRDREGRTALMLAAAHGHKATVETLLAANADVSLGDSCGRTAVMLAALGGYDDLAVQLVQNFCHAGDLMSAQTSVLHCAAVGGCWRTTVAALKRAVPPDAQLMGGHAEASARLALREDVDGHTPLYLAHAFGSARVLHELLQALFSFCGEGESAQGLLARLSTHEGGAIEKRILLCDSTLQRYGWLSGVLEINAALGEKVRQGYEQSPAALGLRAGQVTYQPVVPSLRSAASLLLWCVQAGNTVGLRVLADYNISDDCGVLHVAAANGCFNVVKLLVQLEMSDPSVQDVRTGRYAFEWAALYHHTECASFLLTHTVLDCAALLDRYFSSNDNGVMEGEGAPPARNGGRRREDPSDNALGAGGCSSAVSSVVPPLHVMAGHCGGQLLVQFVEETLDTAARTYVAPSTRHGGASSEQNGAEVMSLVLYRALQRPAGPSRLTPLEYAMAIGDPAAVLHTLQVLRRLQEIADALRPSSAHFASIGSTRFSTTGALQWSGGEGIVSCQSGDQVAATRTGAVFVSKSFLNWVPALSPAVHTVLFDVLGIWEVATVAGFAPQRLAAQASLTPPHSEGSAKADGEHGQQQRGKDEAAARKATTSSLASTPRVRFSDVRLLGIHALQQDDYCAEVLHDFFTPDHEREVLRLLLQDFPYKIRYEPDSYQQCSLSTQTHLLRWLGTSLVLGTYDVPPPSGVLTTSWATSVGVEQGKVADFDSIEIQVVLYRGEQFVELTGTALSHSLYLSTSQHTLVVPDVMATLPRTLCTQREVWLAELTTLSARATRLLQRQAHPVMQRSTVTVDWNLSTMSDDAGANVSADLDRYGAIFVRVCDALRALMGWVRGPLRSLLAEVDATDLAAVVIGVRQGGMAGLQVRFRYVTEERVVTRFPTASTAEASSMLMFSGDAYPSCCIEFNETTHTDVVHACQATIGRAIAADVALVRVHHTRDRFLHLVRRLLSAPKGVAVVSTTLSRQLEVAKECIQSAAADSLTLPLGSAKALNKSNHTSSASGVATSSPPSELLRFKLELEGTTLDAMPIQELERLLLAETTAAVDAVVSPWPHAASPSRKSTTGAETKVYDAFHSAAILSAALVRRLRSVLVLFTARRDAMVRLSSDKLMLCFTADEVPSRSDIAAEITRTLAQEECDLYRRRLTEVHEMMTQRLTAYLPHAKLVVDVEAMQRLAGDEAHLLSAMRLLVYQQSEWVLQRLVEGVSIGWDTELGAVVRRHVRQVTLTLDPGLYGTCYLSPEGVFAYYCPLLCLERQPPGALTPSSLPSWQLLSPQQIASLLLMQLAVREPQVLQFVDRKRSVACWTTARRIPRRILPGSPVHIEVQARNLFNRPLRRGGERLLLMGEVGEPRVEDTGRGRYVIHFEAPQRAGDHRLFILLHGQPIAQSPLRYTVRPGVVDLGRTRVRDKFNAVVIGVPFTVLLQLHDAAGNRLLAALSDLKVARASPASMVQLQVWGWQGPGTIGVTLRVLPTVPTKTTLIISLALTCQPTAAGAAANGALCTATVSLPAYLCVDSKTYQRICRVRRGLIVNNDLPTSCPNLYTYPGVASTPLRAPSQPSSLYFRQAVRGAARKELAREAVTLGDALNYRYPRNAAMKELEMSTKSAAAKKPGGARTCKAPVSDTGSATVSPTYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S095</accession>
    <name>A0A088S095_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kinesin, putative</fullName>
            <ecNumber evidence="5">5.6.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_341920</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.3" evidence="5"/>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702618.1">
        <property type="nucleotide sequence ID" value="XM_010704316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S095"/>
    <dbReference type="GeneID" id="22578697"/>
    <dbReference type="KEGG" id="lpan:LPMP_341920"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340025300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_341920"/>
    <dbReference type="eggNOG" id="KOG0244">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="KINESIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115:SF953">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="4">
        <location>
            <begin position="8"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="250"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="500"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="99"/>
            <end position="106"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO01818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="694" mass="76957" checksum="94B5F5825264D157" modified="2014-11-26" version="1">MTTVGNQRVMVSVRVRPMLREGAINHQQEKFELQGVHRTGDTTLKVEVTKQGEPTKSSTFSFDYIFDQESTQLEVYEDAVVDMVDGALVGVNATLLAYGQTGSGKTFTVLGDVKPNPLENDLLTTDSGMFLRVLSDLMDYKIRQAKKGWHVVVGLSCIEIYNENIRDLFGGKPGSAPPPLKAVMTGEDVHLPSLIIKEMMTLQTVFSEIQLAISRRMSRATDSNSQSSRSHCLFSIDILQQADSAAAPSLNILDQSRKGNDTKKTLGSDKKGASAASRKAGSPTSAAEPQMAAWEMPFQGTVFRIPGQKEPVYASKIILADLAGSERIFRSGVTGDGLAEATAINSSLTALGNVVHSLHKGGFVSYRVSNLTRLLKPTFSHPSSRVLLLAQCSPTQMSYDETVSTLHFANKVKDMKVTTSTGAEAEKLQFDFLESGKMCDAILADLHIFAVESQAKAGIIRRKVMQQNKLYYDVLASKNGKTAKVTMRDRRFSVETMGAVAAAQEERAELLARLEKERSEEDATRQQMVNECCDEFVKEHMDEVKETKEGIEEQVNLRVHHKSQQMLLESAACGRRIMEEEAEGWASLMLLYLQEHNSLCSKELETTSKLLEEVAQNVYKLGVSGVTPEEAEADRTYALSAWYHCAAKRFFSICMELYEDYVILLSTSRGNAMLERWKKKNHSLLQKFQEESSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0D4</accession>
    <name>A0A088S0D4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_340620</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702489.1">
        <property type="nucleotide sequence ID" value="XM_010704187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0D4"/>
    <dbReference type="GeneID" id="22578566"/>
    <dbReference type="KEGG" id="lpan:LPMP_340620"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340011700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_340620"/>
    <dbReference type="eggNOG" id="KOG1840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5986190at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000935">
        <property type="entry name" value="Predicted TPR repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001165">
        <property type="entry name" value="Predicted TPR repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000772">
        <property type="entry name" value="Tetratricopeptide repeat/TPR repeat, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000844">
        <property type="entry name" value="Tetratricopeptide repeat/TPR repeat, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF19">
        <property type="entry name" value="NEPHROCYSTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="408"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="492"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="602"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO01689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="622" mass="70310" checksum="0DD52B42124DF86D" modified="2014-11-26" version="1">MSFEFGEECNNLARAAHQTKNYGDAISLYDRALTMRREKYGPIHEKCAATLHNIGRVFIDMKEYGAAENAFTEAAAIYEQVEGDKSLKYAESLELLALCYTHLKFLDEAEKAFKDSIRIFRDECYNYGSNSWLPDDKTPPAEPNKHPLSSAAHALADCAALFLFRRQEHQAVAFLEEALEIRRFLYSRHVKFRPMIAQTLNKLCELKKSLDDAVGAEMCISECLQICIETLGRDHPATAQATSSKAGLLAAKKQFRDALRLYEESATTYAVALGKDAPLFGQELMKLGRCQELCNDFVSAEKTFQRGVEIIKKGFGTNSPQLAEANTFYGSLLARKLEIDQAVSMFRDAIRIRKSVDKNDPQLAYLYQKIGDAYAMRREPHAEAYFLLAVDAFKQNATIEPLQRTYMTDVLDDLGLFYLDFQHYEKAEKCFKEALDTRITMLGENHATVAYSYSNFALLYLQRQDYANCEKMAAAALDMYSKTARSNVLAQADVHTTLGQCYHQQSQFAKALEMHEKALNVRRTRGDTTETAVAESLNQIARVYVTMKRYGKAYRHVKEARRLVWQFNVEITQPLRNEIAKTEQMIPPIEEWTNEERAEAQVKIGDGNAPGGGNASTTATSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0I3</accession>
    <name>A0A088S0I3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Endonuclease/exonuclease/phosphatase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_340640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702491.1">
        <property type="nucleotide sequence ID" value="XM_010704189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0I3"/>
    <dbReference type="GeneID" id="22578568"/>
    <dbReference type="KEGG" id="lpan:LPMP_340640"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340012000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_340640"/>
    <dbReference type="eggNOG" id="ENOG502RYN4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="200415at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="494"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="46"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO01691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="522" mass="58744" checksum="51206644B4CBAA69" modified="2014-11-26" version="1">MPLFNNDNDEKALKVMKAGDILHYDYRPADQQSGSGAKLSDTFRVVQWNIERGTKLEAIIADLKALHADFIVLQELDINCRRSNYVNVPKEIAKALKAELYFACEFEELDSALRTPMNAVGPRSQPVLETEASPNSGRSDGSTLKSSKRHHFHGNAILSRHVTLRDPTVVPHTNPIMWDEAGHRYNEPRRGFRSALRVRVDAADRTSAQMAPLYIYCCHFEVFGGCLARVRQLADCMADMQRIRHVSTVVNGTNSRHPVFLLGGDLNTFAHGIVRLSWRYGTGRLRWLSFGECEACWLQRKVLGRNMQFLEAGCCPLSYRFLAYAVSWARQLLCNNSLVWHYVYGFTKAEQQRMANADLCLYDPSDKATSITLDNAAYHGFVRGKLDWMLLSNLQPRPFRTARDGAEPIDLAVLEKNGSILTTSYTARYLHFIQDSSQDDEAAAKSVPADGYLLFNENYTASDHRGLVMTVQQNNGRPQDVYPSNGAPYTTSRAALAFFTLTRALPVAAVALGLYHKYKTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0V1</accession>
    <name>A0A088S0V1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_344110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702833.1">
        <property type="nucleotide sequence ID" value="XM_010704531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0V1"/>
    <dbReference type="GeneID" id="22578916"/>
    <dbReference type="KEGG" id="lpan:LPMP_344110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340048400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_344110"/>
    <dbReference type="eggNOG" id="ENOG502S1TG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272317at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO02033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="305" mass="33285" checksum="3BA5A2657AA0150D" modified="2014-11-26" version="1">MPPAFARASSAFSAFPMKTYSTLECGSQRQMHDMLRHTVERLWYPFTQGHRGADLNTYRFREHIASLCCPGNAFTCQVNGHLGGTRVLEDFFATVLSGFDIIHASVDGSRGDSLSNPADMCNYTGYYVLAHTRPFLGWMPSLTSLRGATHTSVLPEVAICNSIECSFNGAAPETTSRSAFLLKDVDEAEDTNATVTIGGELNAGAVQANASSTVCTLVVPFTMYVEGLVDRNRLSHIVLRTPVMELLRTRLECPEAVQECLGSCEALKMFATLRRAGVKPELITAKTLLSVSRQNATWMSALGIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1I7</accession>
    <name>A0A088S1I7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Exosome complex exonuclease RRP40, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_040140</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="AIN95341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703663.1">
        <property type="nucleotide sequence ID" value="XM_010705361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1I7"/>
    <dbReference type="GeneID" id="22571973"/>
    <dbReference type="KEGG" id="lpan:LPMP_040140"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040007100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_040140"/>
    <dbReference type="eggNOG" id="KOG1004">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="340500at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000401">
        <property type="entry name" value="Exosome complex exonuclease RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000131">
        <property type="entry name" value="Exosome complex exonuclease RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21262">
        <property type="entry name" value="RRP40_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0271">Exosome</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN95341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="300" mass="32188" checksum="F94440BA8E94DAB0" modified="2014-11-26" version="1">MAQPSAVVAIGGGLRLLPQLPPTTNTDDASQALTDVFLSEFCAPLQCSSHQLHTHVPRYMVPTPASRRYTPRAGDPVLAIIARKVSQHYYYCYIGSSALAYMDALAFDGATKVNRPRLVEGDVVYCYVKPRAASSYVDGTPRSVASGVVDTAGEVETSCTAAEVGLPPKDWTSGEAVFGPLHGGRVLHLPLAYVRRLLMPMGLSPGKASAQQQKSNRTEGEISGGEEVPASYLLQLLGRRVPFEVAVGLNGLVWVRGLSSEADAMAAARRTVAVSSCISEAQYDITRAEMEARVEAYFPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1R3</accession>
    <name>A0A088S1R3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_041090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="AIN95431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703753.1">
        <property type="nucleotide sequence ID" value="XM_010705451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1R3"/>
    <dbReference type="GeneID" id="22572068"/>
    <dbReference type="KEGG" id="lpan:LPMP_041090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040018200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_041090"/>
    <dbReference type="eggNOG" id="ENOG502SJ7G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="261884at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="303" mass="32182" checksum="B8D6E7197B4E483C" modified="2014-11-26" version="1">MSSTHTAPPTMATKRCYAPQFLEPGQHIKVASRKPASKLWGAAGGDPLAGRPPRDPWEDLDDSAEEPCSTLAGEPGSQRPHRHHTCTSGGHPYSDRLSASRSNAASTSPHSKEGRSSDLAPSTEATPPMDDLNAAGDEDVDCGATINNDREKNYYSATSVLPELSAAERAKRVRDAQQRALEAKHLNALAHQRVAPRPKTLVRNRHGRLNAIAIHPASGTEKEAGPTMLISDTPASPSGQPKMMQGCSSTPPEAQPEPPRSHDDEGGSDSGVKSPQDSHNVLTESCSSALLEVPPGQLEIDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1R6</accession>
    <name>A0A088S1R6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mitochondrial inner membrane signal peptidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_350190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702959.1">
        <property type="nucleotide sequence ID" value="XM_010704657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1R6"/>
    <dbReference type="GeneID" id="22579048"/>
    <dbReference type="KEGG" id="lpan:LPMP_350190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350006900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_350190"/>
    <dbReference type="eggNOG" id="ENOG502S1QN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="308440at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052064">
        <property type="entry name" value="Mito_IMP1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383:SF16">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383">
        <property type="entry name" value="PROTEASE FAMILY S26 MITOCHONDRIAL INNER MEMBRANE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S26" evidence="7">
        <location>
            <begin position="31"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO02159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="220" mass="24873" checksum="516BFC4012A8E2BE" modified="2014-11-26" version="1">MMSRLWWSTLRSSKYGDVPFVLLGVFIGWNCDVSCAVKGVSMVPTLQPGEYILFVPYTFLQIRRWFNAPMVNLSDVVVVKVSDDLSVCKRVVRCTTSRAQADEWGRDHYVEVVPAPYSTPVAEDTNGDAGSTDEDALDNHEQAYFDYVSQNTVRSKDWDSCIDRIPNPSQWIWLEGDNQQESFDSRRCGPVPVECVRGLVLASIWPSPHTLHRPPPSNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1Z2</accession>
    <name>A0A088S1Z2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA splicing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_050590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="AIN95501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703823.1">
        <property type="nucleotide sequence ID" value="XM_010705521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1Z2"/>
    <dbReference type="GeneID" id="22572137"/>
    <dbReference type="KEGG" id="lpan:LPMP_050590"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230027800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_050590"/>
    <dbReference type="eggNOG" id="KOG0151">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="377209at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051485">
        <property type="entry name" value="SR-CTD_assoc_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140">
        <property type="entry name" value="RNA PROCESSING PROTEIN LD23810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140:SF0">
        <property type="entry name" value="U2 SNRNP-ASSOCIATED SURP MOTIF-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00648">
        <property type="entry name" value="SWAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
        <property type="entry name" value="SURP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SURP motif" evidence="2">
        <location>
            <begin position="229"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="618"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="694"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="769"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="847"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="465"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="695"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="726"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="802"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="816"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="847"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="873"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="991" mass="105158" checksum="4BC6431237D44E2D" modified="2014-11-26" version="1">MKRQFLPHTPPCQSRQQSGASATRMFTGNAQESEDFAEMDDSHSEVGFDSSTVLLYDTSHQLTNKPADGPSGESGTGSSNTGASPYAMYEPTYANKQHGLLGSVFKGEATVTAAGWSGGSVFPAPDAPYSQPLLHPPQPPHLLPPPYLSAASAQPPFTANSLGILGPGTTAEGGSGPPLTSGYLSPTTATEPGTGAAVKVVPPTDVLKVPLHAPRLRVPANLPLEQTTLLDLLATAVVQGGPTTEEEIVKREMGRGNLAFAFLGEKFNHPCMLYYRWRLYSLLQGDTLVSWRTQPFQIEEARRAYVWVPPPPLKVGPECLVGLHQPELLDPVFATGSGTDAAATAGGADDEEGADVIVRMAHRRGGRHRRRHHCGRDAEADMKSKRSRHDAGDERGHGSRSPSDSSGSSSGSSLQSSSNSNSESDDEQDKPKGRRATLAECGNGDEEATKAKDQPLVQPPVSTGAEAMSSEAAPADAARVRLPPPSAQWISRQCTAHRHVFAILQPHLVAKWTALLNPYAMADPATVGNSGLATLCERWLRRDEVASRMAFAIRHAVAMHHLLSILLDAVVKVAYVATAQSRQQPTDSVDHLDSNVYCVEALWYLFVLHDIAMNASNAPETSTTSATSVNKNAPNRQQPLQPQQGLATAAAGIVSGATSAGRTDTDEELFASEGNLEALETLYDVLSRQHLATHAGASTSPSPAAAAGVATATAVSSPSAPGSTLRPRRRQRHPQRRSSYERCGDALEMILPTLMEACTAIALAVSMDKERQRSQTMTASSTRARHFKVLPPHQQHQQQQSKTKDKLNATEHESMMPSSSATLPVSSGPALSLRLDAGCDAAAATTASSSSTWSPSSPSAEHRVNTAAGGGAETATPSTSSTSSAPAVMLLYWLKTFLVVWMNVEQPLQSPSAGAGMATGAVVPPGTVWPDCQANAADMLDVKLTYHVNPQHASLLGLDAASQQQRSVCHQPPLLSARACAILKDRYSFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S263</accession>
    <name>A0A088S263_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mismatch repair protein MSH8, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_352020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703139.1">
        <property type="nucleotide sequence ID" value="XM_010704837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S263"/>
    <dbReference type="GeneID" id="22579231"/>
    <dbReference type="KEGG" id="lpan:LPMP_352020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350026300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_352020"/>
    <dbReference type="eggNOG" id="KOG0217">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10252754at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000014">
        <property type="entry name" value="Mismatch repair protein MSH8, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003151">
        <property type="entry name" value="Mismatch repair protein MSH8, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000068">
        <property type="entry name" value="Putative mismatch repair protein MSH8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF148">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="6">
        <location>
            <begin position="851"/>
            <end position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO02339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1014" mass="111819" checksum="B93CE8702BE37559" modified="2014-11-26" version="1">MALVDSQVDVNSMSFTYPFLEGIDPTAPPSTITIPQKYLDAMANMERQYWDIKSKHYNVVVFFKKGKFYELYDYDAVIANREFGLKMVFDTSNRGKMRLAGVPEQSYHEWARLFVFRGYKVGRVEQMKEGENEAQAAKMKVVPRELVEILTPGTLKDPSMLSDHREVFIVSLAPVYRDGEFVIDAFAVDLSRRVAYRCACDYHNRAFRTDCDSISSEFGIKREKEFPGSLNNSTLRALSALLLQLNPKEVIIPSSDWASNDVEGYQAFKSTCDEITKWTEGEGFPVEQISNKTLTSLSMPDIATAEEVMASYFTFLCLTSDIAIFSAATEYTAHLPSAISVDCGVAAPDAMLDEAAGRKSSIMSFERRFDKGLVLDATTVSNLEVLTNLHDGSDKHSLNECLNRCSTNGGRRLFRSWLLRPSANARVIAARQDTVQFLARYNLVHSLKEMEVGDQVGVKRSRSNEGLSLFSFVVSIDFERFLSRLSDIKLNDSQNIAYIDPMVQYKKNLGIILSSVQALVAMVGWGRQFLERCREVASEQSADVPALLEELLEEVTTAETSTKRIEGLFDRQSAEESGLLIPSPGTSSVFDAATAKLKHIESKLHDVRRQLQQDVFQGAQTHFADLGKDLFLIEVAVADAPKMTPAGMIERARNAKSVKYVVPCIETLVETHKEATAMKAGALLTVLCSVASRICDEFPCLFSATRALSYLDCLLSLAQLQHAFPTVCYPQLCTAHERNVAVVRGCDMIHPLLIAKNPVANSVSLDDVEGRVLLLTGPNMAGKSTLMRTVAINVLLAQLGGPVLATKMEFSPIDRIFTRIGARDASHKGQSTLYVELSETAAILHSASARSLCLVDELGRGTSTHDGMAIAYATLHALTATNPAAPLTIFSTHYHALAMEQARRATQTPTDTRARAVQLGYMDFVLKSETAAAFSDEKANDASCSCAQGSCVSSVAFLYRLVRGICSRSYGVEVAVMAGIPHTLVQLAKAKSEALSRETAFHEDVRSIEKFICI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2H9</accession>
    <name>A0A088S2H9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">S24E-1</name>
        <name evidence="7" type="ORF">LPMP_352940</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703231.1">
        <property type="nucleotide sequence ID" value="XM_010704929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2H9"/>
    <dbReference type="GeneID" id="22579323"/>
    <dbReference type="KEGG" id="lpan:LPMP_352940"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350036800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_352940"/>
    <dbReference type="eggNOG" id="KOG3424">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="260791at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3370:FF:000001">
        <property type="entry name" value="40S ribosomal protein S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00545">
        <property type="entry name" value="Ribosomal_eS24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053709">
        <property type="entry name" value="eRP_eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001976">
        <property type="entry name" value="Ribosomal_eS24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018098">
        <property type="entry name" value="Ribosomal_eS24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10496">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01282">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00529">
        <property type="entry name" value="RIBOSOMAL_S24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="100"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO02431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="137" mass="15873" checksum="B09D3B23972425AB" modified="2014-11-26" version="1">MVFQKKKAEVSIRTSQFKVNKLLNRKQFVVEVNHPHWCGTVPTQLIRKKLATLYKVPDENQVSIFGFKTKFGGGKTTGFGLIYDDFASLKRYEPNYRKTRMGFGKPQLPARKSVKERRNRNKKLRGKAKGKQVAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2K9</accession>
    <name>A0A088S2K9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_354970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703428.1">
        <property type="nucleotide sequence ID" value="XM_010705126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2K9"/>
    <dbReference type="GeneID" id="22579525"/>
    <dbReference type="KEGG" id="lpan:LPMP_354970"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350058200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_354970"/>
    <dbReference type="eggNOG" id="ENOG502SAZH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273528at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="585"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="543"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="585"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO02628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="607" mass="66835" checksum="161F01F8750AD55A" modified="2014-11-26" version="1">MSGITVQLVFAFIGTRVPYFIPEATTAASSPARSPFGNASSVSFNAPAPSSLRADSTGTSPSLPCILTNQFTAHRLLSRLAKSLEPSLQATATAEDATTEFTRPSPTFSSPFHKPPTFELFDYASLNPLEDKAVLHDEQVLLVLCDTATTTQLVEVLQLEWLEVYSGVHHPHHHSRSSSTLALPHKTDMAVCTTEEKLRNVVHAQQALCKPVALHLSLLAKELASREATLATQKEQLSQLRSSITAVVATAGSFTRSGSDYASSQMSPDRAASFPLLAELEPSLALELARSTTDSAHLQKVEAPLAFCDARLRAVETLLQRAAKHRVKLLELAAGERATEEAFESGPVSRACAEYLERAEQDRSAAEAIITDYQVEMTRQLKVVRQLITYITQVRRLLSKAKHDMGVVELILSRLSLTGLRPRLMEEAEALLCRRVILRRAARRQMLLLQETEFVGLQQDLETFSQRTEVQKVLPEKVRWYLRAPLPTLLPEEDPVATLLDHALIDREEDEAQELVEKTRVCTADSSDPAKNALQISKVLLPVERLTRSLEEARASVAQYKSHVEELEEKLKMYEAADALSSPLLQDSVVKSSSMETQAGGASGKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2Q0</accession>
    <name>A0A088S2Q0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_342240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702650.1">
        <property type="nucleotide sequence ID" value="XM_010704348.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22578729"/>
    <dbReference type="KEGG" id="lpan:LPMP_342240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340028400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_342240"/>
    <dbReference type="eggNOG" id="ENOG502SJHY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272537at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="766"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1111"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1163"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1120"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1141"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1180"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1213"/>
            <end position="1227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1299" mass="137726" checksum="C9963D84DCEF4523" modified="2014-11-26" version="1">MIGSTAATAGSGPSKSPSSETVATGVTPVESAVSLRSPVDTLARAQKLPQAFTTSLLNLEVKVLTQALGAENQWAEQGDGRVAFCDFTIRVVAPEVSKEAQKEKVAELTPSGVADAAAVHGNGDVGAATRKSTAAPNASALSNTVSEFDEDDPADEMIILEDTISSDTPFVGENCCIVWNSFEKQLSLCLMYASEEGYSASWSALVALQDKSYPAFRFDLLERCRPVSEQTVLAPGASTSSTTSSTAATDRTEGVVLPYSYFIHAKYDPPLGFIEQHALSLSIIEHRHGTNRALYADKGTVLIMLSMGNADLLDCLISEATFPLLLSGLQCAAEPLSWSVPEPLQLLHIPEEVTNLIRKDRWIGFLQETVFPSCGAADLVAELPTKFAAMSRRIRNDIVCLLLSCDNLFSEACEALRVMPPVMSGTMSGGPSARSRVPSSETSSSATSFNSEGRSSMGAVWNGAPSPSSTPPAMDIMSLAQKAELQVLAHLRFFRELVTLSIAELGREMVGPIVGKIYHSGLLEPLSLVAERFAMPSGTAAAFVKHVMDSSGGGVNGARRCGGGGAASNSSSGAADGTSSTANYYSLAVEQELAAVLDVTLVRLNERQEEQLMNEHVRAPILADPVKYNGIVTFMLRQLIVSGTTGAALSTGLPGISTNATRPTYSIFTSSKRILRDSMSSSNPLVLFHVLGLHDDEGSATSERLLDAESTDIRNRFHNFIITKYIAHATRGLMTPVPLPPSLSGVVGPARNIPIVQFSNVSVTQNSGGRPVHHDGNGGGAGGAAVVASNTGPGSGGGGAVSPVLPLPQGITPALVRVLEYMVSLTNNANRELMLKTVFHYKSHIWQFIEGVCDTLCGANGAGARCQVGLDVLCGCVRFLKVIVMQMTVVTAEADVNPLSSYVPSREALSPQLITTICRQLTVERDTFGYLLKAYNRLGGLRRNSVFHSSLRAVFDLIGKCSTREPEESATNNLRDVRNYLFFKHLTQLPEVFACRYREALLSEVTVRLGQEATHSPNDSVSVLSSTAGSDLTRCSSKLRFVDELEAVSGGVDGTVVPSSVVSPAIMVSMANAEEKQRKRNIRSSVEQSNMIANHVVGPLPQVRTLTPLGLADAHGGRTSPSFSPSDRVSSPLTISITCPSSSGSSSEGGFHAPVSDLFKINAAQPNGSSAHGDGPLGQVGSSSAAGSNTRETETVLQPTVPREEKPPGRPRNFSSVLENSSRTSTAVFGEQVGRSRSMASTTTRDAPPPSSPEVLLSKSGNSSVPQWLERANEIASPSNDNVVLPKIKKRLSTNGKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2R5</accession>
    <name>A0A088S2R5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_342440</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702670.1">
        <property type="nucleotide sequence ID" value="XM_010704368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2R5"/>
    <dbReference type="GeneID" id="22578749"/>
    <dbReference type="KEGG" id="lpan:LPMP_342440"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340030400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_342440"/>
    <dbReference type="eggNOG" id="KOG1311">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4096362at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF478">
        <property type="entry name" value="PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="107"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIO01870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="279" mass="30711" checksum="34CCAAA80AF4B620" modified="2014-11-26" version="1">MHLPPGTTKRALGRLRIVWCCVVTAESWHAVFVGAPILFFATLFVTVVVPRGEWLTYLFTAFFTATSVTCLILSVTLDPGIIPPASQSQQPAEPAVVLVSGKPVVCKVCPTCHILRPPRSTHCQFCDVCVEEFDHHCSILGSCVGKRTFRFFGGFFIMTSFLALYVLIRSFITVVTTDFTLANDQSHLIWLAASCILCIFAAIIGAILVIPCAARYVMLSATNSTVKETMRTQQQSPSGKQAGGCLPAAEMRIDNYCLSLVRRLFSPIGRSRIPFDYYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2V4</accession>
    <name>A0A088S2V4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_354120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703346.1">
        <property type="nucleotide sequence ID" value="XM_010705044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2V4"/>
    <dbReference type="GeneID" id="22579440"/>
    <dbReference type="KEGG" id="lpan:LPMP_354120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350049400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_354120"/>
    <dbReference type="eggNOG" id="ENOG502S0E5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270755at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="519" mass="57846" checksum="9FB518F0B3234EB2" modified="2014-11-26" version="1">MENLPNQLMSRIAELSLSDAQIQSYGRWLVFALGAYYISSTWQKSIPADVQAAITGHMVQGYDRSAITTRLEQRHIRQLLQQITGLNELRQQLRSKIDKEAKLRGWQRVFRLTLISIAATTYTHSLTISLLSIKNMVRVLVFLLSRRESAALSKSRSGPISAVRAWWTGGRRAGLTGIMMESMMAKMAEQASQQASPFANAELEEVAVTEGLRQLPLPPPIDGRAAFVQAQQQQMREAVHRESVSQVEQAFSVRAVLEVAVPRIVACAAAAVDSAIAVRPVHLFSVSGIVRAADLRSLLCDIALRMERRACVAEWVRRPHHSLVTMSRQRSGASSSLLTSPQKPLDPSKGRLQTNEDEELLDERDQSATSSEDIIEFPHESTTLLRPDGRQMRRSEDQVIDEMLGRCFTAEEEAQQEEAIRRDHLLKGQMAGFFTELSHSASFGELCITYAAELLATQFKEAGDITHVKTYDAATDTAKMAMVIAALDSCRLAALEEECEVKPYLRLFCEETIRSTCAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S390</accession>
    <name>A0A088S390_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_344390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702860.1">
        <property type="nucleotide sequence ID" value="XM_010704558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S390"/>
    <dbReference type="GeneID" id="22578944"/>
    <dbReference type="KEGG" id="lpan:LPMP_344390"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340051800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_344390"/>
    <dbReference type="eggNOG" id="ENOG502RZW0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272831at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="566"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="718" mass="75528" checksum="6B61FCD8FF9766BB" modified="2014-11-26" version="1">MTTAQDSLRSAPAAGAVEMQTLLPSTCGEEVDLPGVPRVGCVAAISYKPHSLHGFSACVVGMADGISILGPDLTQRHYGRHCLLTRHLWRPAALFEGSGERPNATAHECGRPAQSRNGTAMLPHTKGSYASIVAVTACLVAGEEGNGANVALETAEDDTIAIVVAWSDAALHHHVTVLTAHLRCILTPSSKRCASSGSVHVEAGLVQVVAHDALPLHPMQSVLRLFYHSAMATSQNESAPHHVVMCSVYSPLDWTMSPERHFGLSDPGATTNNTSPSSVVKPSHPNAGSGSAVAESVAPSAATAARGHGGLLFLTVSAFHDSDTAGEATASASASLKNACANNGIRVCAGPSAGKDVAPWLLQFQPDRIVCAFAVQSATTSVIAVAGTTDGRVYLLGQTSQRLVRRVSGPVADAMFVQTKLANVRSRTRNAVVDGLLNEAIEEDTRRSGGVLSQPDDYAPHDESDSATLVILESAGHLLVLRAINSDAPITQSVADISQVITLANGRQQTLTFVDSSMENLEESTHISSKSFLDLSSLRGFFGRRRPPVPPPPPEQYQRKLGRSDSSPTNPPLASSSLTTSPANQSFLNGAMGIEEIHIAGHILSRGLLCATCIYNAQGGAELVVSTMGQVVVSVPFSPTDGCFRIAGFTKMPAPMFYVGFVDFFAAGNPMLVMAGLKSVLVANRPQLTIRDRAQLLLRLLNKKECEQQAAESDGVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S4B4</accession>
    <name>A0A088S4B4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">S-phase kinase-associated protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_111170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SKP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696964.1">
        <property type="nucleotide sequence ID" value="XM_010698662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S4B4"/>
    <dbReference type="GeneID" id="22572982"/>
    <dbReference type="KEGG" id="lpan:LPMP_111170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_110015600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_111170"/>
    <dbReference type="eggNOG" id="KOG1724">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2342932at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18322">
        <property type="entry name" value="BTB_POZ_SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000026">
        <property type="entry name" value="E3 ubiquitin ligase complex SCF subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016072">
        <property type="entry name" value="Skp1_comp_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01466">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028729">
        <property type="entry name" value="E3_ubiquit_lig_SCF_Skp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="5">
        <location>
            <begin position="18"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="SKP1 component dimerisation" evidence="4">
        <location>
            <begin position="134"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR028729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN96311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="183" mass="20990" checksum="153B69CC95D4BAA5" modified="2014-11-26" version="1">MPVEIANGDDVDFSQYCVLQSNDHPPVEFKVSRESAKMSGLLRDMLEDQEGSEAIIPIPNVSGQTLRLVLEYMEYHCGNPAQPIEKPLKTAIESLVCEWDSNFLFSKLLKNHDERQHEVLIDVIMAANFLNVRDLLDLTCACVASMIRGKTAEQIRELFNIENDFTPEEEEKIREENRWCEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S4B7</accession>
    <name>A0A088S4B7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCZ1/INTU/HSP4 first Longin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_353330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCZ1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703270.1">
        <property type="nucleotide sequence ID" value="XM_010704968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S4B7"/>
    <dbReference type="GeneID" id="22579362"/>
    <dbReference type="KEGG" id="lpan:LPMP_353330"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350041100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_353330"/>
    <dbReference type="eggNOG" id="ENOG502SE3F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="240546at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013176">
        <property type="entry name" value="Ccz1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043987">
        <property type="entry name" value="CCZ1/INTU/HSP4_longin_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13056">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN CCZ1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13056:SF0">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN CCZ1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19031">
        <property type="entry name" value="Intu_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCZ1/INTU/HSP4 first Longin" evidence="3">
        <location>
            <begin position="15"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO02470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="520" mass="56950" checksum="ADCE97AE1B835E45" modified="2014-11-26" version="1">MVLTTSPDVGEPLISLAVYCPLLCADKEERGADNILFYFPPDTHLNSQMNQVGFCIAISSLAPRFGVHSSRLQTIRKQRSSVCLLSPAEDLWVSAHVRGGNEAALTTHHLLQLSCALFELLYSADTMGLLTLPTIENSRTKGSPTLSGSSTSSNPAAEQAATSDTAARAALRSFFTRCATFISSVLSAQCKARTGETEPTSRSAAAMSAQDWAHYLSAEASFGLPLRFVSNRELSSLQLGRVEEVVRHILWQRAGCYAAAPDGDTPSLLSRNHVRYCIFNLPQLHVVVADSQLPRIVVQVLRYYLVLHAPIVCTSFQCYVQPDGLCNVAVWLDGNVVVVLVESHDDLSANVGGRAVSSALLEHASIIGAKVRQLLSKSAAGATTVEAKDAYWLSTHSVTAHQMYYKSTVKPSIAASNGLVAHWRFRGAVVEGTPLRHVVPGLIEYVQTLVYWTKLHLPSSTLTSVLECWTRWNSLWLYLRFANSTVTVLAWQQQQQQQQQSSVSVRQLAYEVQRLLLLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S5T7</accession>
    <name>A0A088S5T7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein tyrosine phosphatase PRL-1</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_160260</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN96901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697554.1">
        <property type="nucleotide sequence ID" value="XM_010699252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S5T7"/>
    <dbReference type="GeneID" id="22573603"/>
    <dbReference type="KEGG" id="lpan:LPMP_160260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160007100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_160260"/>
    <dbReference type="eggNOG" id="KOG2836">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5632at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14500">
        <property type="entry name" value="PTP-IVa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000086">
        <property type="entry name" value="Protein tyrosine phosphatase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057023">
        <property type="entry name" value="PTP-SAK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22784">
        <property type="entry name" value="PTP-SAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="11">
        <location>
            <begin position="13"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="12">
        <location>
            <begin position="85"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIN96901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="176" mass="19644" checksum="2A90A6FF0266F30D" modified="2014-11-26" version="1">MDIKGTIVDCKRSGTEEVIFRFLILDAPSPSSLPTYVKLLQRQNVHHLVRACGPTYNAELVEKNDIQVHGWTFDDGAPPTRAVMDRWLDLLSQEVGKTPPETIAVHCVAGLGRAPILVALALVEYGNMAPLDAVGYVRERRKGAINQVQLNWLMRYKPRHHQASDRSLVCTNCAVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S660</accession>
    <name>A0A088S660_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Elongation factor 1-alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_170080</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697699.1">
        <property type="nucleotide sequence ID" value="XM_010699397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S660"/>
    <dbReference type="GeneID" id="22573751"/>
    <dbReference type="KEGG" id="lpan:LPMP_170080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170005000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_170080"/>
    <dbReference type="eggNOG" id="KOG0052">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="256246at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03693">
        <property type="entry name" value="EF1_alpha_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03705">
        <property type="entry name" value="EF1_alpha_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000003">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000005">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000255">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_A">
        <property type="entry name" value="EF_Tu_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004539">
        <property type="entry name" value="Transl_elong_EF1A_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00483">
        <property type="entry name" value="EF-1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008969">
        <property type="entry name" value="PRK12317.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8 10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="5"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN97046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="449" mass="49058" checksum="C7CA18E3C4A6A3F4" modified="2014-11-26" version="1">MGKDKVHMNLVVVGHVDAGKSTATGHLIYKCGGIDKRTIEKFEKEAAEMGKASFKYAWVLDKLKAERERGITIDIALWKFESPKSVFTIIDAPGHRDFIKNMITGTSQADAAILMIDSTQGGFEAGISKDGQTREHALLAFTLGVKQMVVCCNKMDDKTVQYSQSRYEEISKEVGAYLKRVGYNPEKVRFIPISGWQGDNMIDKSESMAWYKGPTLLDALDMLEAPVRPVDKPLRLPLQDVYKIGGIGTVPVGRVETGIMKPGDVVTFAPANVTTEVKSIEMHHEQLAEAVPGDNVGFNVKNVSVKDIRRGNVCGNSKNDPPKEAADFTAQVIVLNHPGQISNGYAPVLDCHTSHIACRFADIESKIDRRSGKELEKNPKAIKSGDAAIVKMVPQKPMCVEVFNDYPPLGRFAVRDMRQTVAVGIIKAVSKKDGSAGKVTKAAAKAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S6S1</accession>
    <name>A0A088S6S1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_180450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697879.1">
        <property type="nucleotide sequence ID" value="XM_010699577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S6S1"/>
    <dbReference type="GeneID" id="22573935"/>
    <dbReference type="KEGG" id="lpan:LPMP_180450"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000038800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_180450"/>
    <dbReference type="eggNOG" id="ENOG502SEPG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273842at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="666"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="896" mass="95008" checksum="E6333B97F15F7F0F" modified="2014-11-26" version="1">MVGVSRGDAQRGLEPIRPRQHRLLPLPHHPAASNGVCAGTDCSQLLPSRCSARPPTVAGAPLTHRRESDVSVVRPVGWGNAVACVGAELRHTGMKPLLPCRPPALPTSSSSAETRSSESVPDSANAAATVATLNFGAALNEQSPVTTERIPSLSPQLSLPYPHSGTTPGVVASCQPHPPSSPTSSSPACKPRCCAPAASLAAISASSSPSPIEDGVLGRYRATATQFIKGIERLNRMTTTMCNADATLIFALTEERTASGKAGARKMARVPLLPLTLCTDGSTVLLVDPNGTERHGNYLQAVDGFHQYLSPFTSTASSRNAAAPSVSSHPPSNVLWWTLTDLQREPSAVPFTTARAALSVEHLIDSQDGVNRKQRFPQPSLMHAAGDETSSTKCPAKVAAMLAAIQPSRLTLRYGEPLVLVFASPGAQVGDEAQRHRIMDGRVGVEVAADVPPRFAASEATSPQEDLKRNGFPHLGYNLLRDIYHGYLPSFLELLYPNGGVQLRGCWCDVPASAVDASTAQSVKLFSQQQLSLHPTVSPMGVGGGAAQRSSPGPLKPRCMQQLLVTMAPMPLLGWSPQSTGAAPHGHRGTAAAAADDIETIMQSLRPTSLRPPWRSQAAFTATHRDANTRKLTTAAPDAVLQLPPAVLRFLAHHDDKVCAVSAKTSSGPRLCLSPSPPPPSEHTATGAAPSPRLTQRRVERHGKPDVCVTDFGPDGPILAINGFDLSRVHSDGDPRGIRDSNLRGPQLQRQWQARSGFDLVYVCALLHAPSQPPPMGMAVKTSVMCKSVVVLTPAGRVELVVPATSHAAAGLITIADVQQSLLCSPVGRLLLLRDEEVVFTYAPGTPHLLETAVVDTAHAVLRLRRRALCPHLEFAKQQMQGERREGDVDEKVGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S746</accession>
    <name>A0A088S746_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_190440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC53 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698039.1">
        <property type="nucleotide sequence ID" value="XM_010699737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S746"/>
    <dbReference type="GeneID" id="22574098"/>
    <dbReference type="KEGG" id="lpan:LPMP_190440"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190012700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_190440"/>
    <dbReference type="eggNOG" id="KOG4496">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268027at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071203">
        <property type="term" value="C:WASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019309">
        <property type="entry name" value="WASHC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13015">
        <property type="entry name" value="PROTEIN AD-016-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13015:SF0">
        <property type="entry name" value="WASH COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10152">
        <property type="entry name" value="CCDC53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="299" mass="31704" checksum="5306B905C1F99C90" modified="2014-11-26" version="1">MAAAALSRTSAAGMVNSTATAAAAAEVDAYAQTLVGLVNRFVISTVQFLNRFSDECESRLVQTEVSLQQLELQTQLLEHMLLSSGAADPDAVEEEEEGGERFDGNDDGASCLEDGDDQDMMRDNGSVASVAYDYRQRHSRGGGPRAFSKKSDVESVLGLPASPSHNRCSGGPPPPPGDYRKGPPRPPPGMSRAATAAQEAEAARAATLSIVGAPVLMPPLSAEAPAPPPPLELRPGRLLMRNHPRLRGYFQLLSLRVPKAFVKMKMQADGFQGEWLDTPDAPAPGGLSAVVRAFVDEPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S7W7</accession>
    <name>A0A088S7W7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alkaline phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_201570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698358.1">
        <property type="nucleotide sequence ID" value="XM_010700056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S7W7"/>
    <dbReference type="SMR" id="A0A088S7W7"/>
    <dbReference type="GeneID" id="22574366"/>
    <dbReference type="KEGG" id="lpan:LPMP_201570"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200020900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201570"/>
    <dbReference type="eggNOG" id="ENOG502RZU6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="278638at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="38451" checksum="04EA6AA1CC579005" modified="2014-11-26" version="1">MKHMPSLSKKVMPPPKLPGTHTNAEVKEALHARALRRTVLVTAVVFLLLVCLTVVSNTARKTVGDTGKPKLLLIVAKGLAPISVRRAMLSNKSPFMRLLSKAGGKFASISANYSTSNPLINLLTGSAVLTADTLAETTSILGWLKAQKKRTVVAAPSMYWSSGEAGAFPCPQVGLLDTECSGQKCPERKDSAYCNAFRKYITCDDHAQLYNSEILLAFEKMLNHSADALYFQLSSLAEAEVNNPKLVVQERSEVNLLDSAVGSIALALSRRTAHKAENWLMIITSDGANSEMTAPLLVVVYTKGELVQLNDIAEDAKTTDVANTIMHWFKGSNVNTTRLLGICTSGEKVENCKSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S8E7</accession>
    <name>A0A088S8E7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_203820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698583.1">
        <property type="nucleotide sequence ID" value="XM_010700281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S8E7"/>
    <dbReference type="GeneID" id="22574593"/>
    <dbReference type="KEGG" id="lpan:LPMP_203820"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200044300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_203820"/>
    <dbReference type="eggNOG" id="ENOG502QUJ5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272073at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="625"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="674" mass="73930" checksum="394C67ACFD6335C7" modified="2014-11-26" version="1">MDSTISLSAASDGSDTLLARLHDVYTRQKRKIAVQKRKQVDVELQAAAAHCSDQPVSLELLSDGTAALFNELEALLESRNGQSSASSREVTLLQHIRQQANRELRESLSFIEEGYTSGFEKILRECRFEERKASLPKAVASSLTTATVLNDVQHSKASAGASSTATLAAPSHLPVAETLSASISFMAESLAVLLQCEVVRVYLYDIHAHLQCVAQFPYRAQRADPMQSSYLAMMAVREVHHIVCQERLVINGWFSKSHDANEDSDTAAARSVVSSTTASGLEDIHTCLLLPIFSPQGAGKPYGMVHAVNKQCPTALGVTTNDSAEVTRVGFTAEDEMLASSVARVLGTLLSRYQVDSFAAGIGEKLRRSAFPGDAEVLSLTAHLPPTLRDEVQEAAEVAQLALSHLTPILVHRVPMNAIYETRTAAGEGRRRKLALLGPREGAISSVEFNLRCMNELWESSRDDNVTLHKQYRGLEEQVHRMRLLLRNLLDGVAAARAMPLSPNVALFLQNLEMYGRSERTERMAAYVSEQMLAIPAISVRGRGAVDTHAEVPQSESDTSTTHGHMKDSELQALRNRHACLNTVTPASLHFDGPSGVRAYTSDPAQKREQVRFIDELCRLAEEKNPLLPPAPRGDARRQAVPREPPAVTHATVARHPKPVVKPEPYPFVRPFKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S8W3</accession>
    <name>A0A088S8W3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_205800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN98071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698778.1">
        <property type="nucleotide sequence ID" value="XM_010700476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S8W3"/>
    <dbReference type="GeneID" id="22574792"/>
    <dbReference type="KEGG" id="lpan:LPMP_205800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200065300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_205800"/>
    <dbReference type="eggNOG" id="ENOG502SHIQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267792at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="278" mass="30226" checksum="EC94E45EB88F6AB6" modified="2014-11-26" version="1">MSAWSNRNLAAMLKEQKASPGAVAVLGDKTRNGDVPKRPVVSVEPAPKFTAPTAAAVVTTGSEPTPEPAAGPEVVYTLIGPVSMPQALAKLVMPSEFRFAGTVEARKPVALQPPVTRQPAEVVPTPAVITPPMPVEALPVPTVTSSSDLQRTPSPKQQEQHHHHQWNPPQPVYNPSVNDYVPQYEGARPYGGELGSVPLFYSTERQYNAQPYHPTYYNLYCSGGYSSSAIQYGGHGDIYHSYYPGQCGSYTGSRLQTRPPYYPPRDPPQQQNPATQYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S9D2</accession>
    <name>A0A088S9D2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_211580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698943.1">
        <property type="nucleotide sequence ID" value="XM_010700641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S9D2"/>
    <dbReference type="GeneID" id="22574980"/>
    <dbReference type="KEGG" id="lpan:LPMP_211580"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_211580"/>
    <dbReference type="eggNOG" id="ENOG502SBB4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="242263at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="394" mass="42231" checksum="98D72EA672EA9387" modified="2014-11-26" version="1">MVAPLSAALALGSPGLRGGSFNHTTISSRATTATCRALLVAVLIFMVAPSGAQGAVMPASFRCLRPFSATDTFSNVAKAQLSQNCDYFYFTVEDAKAELKCASSSAAATVVSDDISCSVTVRWSMRRASDVTARLQRQVGTDKDYFVHDASTASTATLPTRTRNTHQSARVFLTEDDDVWRYTVSLKAKGDSSIHYKGFSKGNGYSLCCNALEEADCAWMTLEKGDNDLDCDEAIGSAFASQSTRTLRSCPLPLPALRCAAGDVDVDDDCGAWAGAGVVLTDLDEDEDSGVFHGVLTKPLHRIVEGPWEVVVQLWRRRQWIPSNGAKASYTIPTDESVEAEVLGRIVVPFTLNVADLQGQGRITHVPSMALTVEDTAEVVMVADEKPAVEAGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SA59</accession>
    <name>A0A088SA59_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Spliceosomal U5 snRNP-specific protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_230810</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DIM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699238.1">
        <property type="nucleotide sequence ID" value="XM_010700936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SA59"/>
    <dbReference type="GeneID" id="22575285"/>
    <dbReference type="KEGG" id="lpan:LPMP_230810"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_110008800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_230810"/>
    <dbReference type="eggNOG" id="KOG3414">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="147752at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004123">
        <property type="entry name" value="Dim1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052:SF5">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEN 4A, 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02966">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01410">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN98531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="217" mass="24264" checksum="CAFC6D2B5964B289" modified="2014-11-26" version="1">MTNIITLHSAWDVDRHIVLDSADKLVLIRFSSYTSAETEAEEYSRPTQRGPTTSASTAVEGSLASSSSALSTRKHKRCDAGGVDGRVVTSVTAAALLSTNANEHYLRTRQMDALLSELAPKVCKYCTMYFVDTREVTAFNDLYELGHDRDPFAVMLFYRNRHIRVDVGTGNNNKINFFAFEDLYDFLPIVDAAYKAGRQGRSIISCDRKFSTVALRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SAR9</accession>
    <name>A0A088SAR9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_240980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699438.1">
        <property type="nucleotide sequence ID" value="XM_010701136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SAR9"/>
    <dbReference type="GeneID" id="22575507"/>
    <dbReference type="KEGG" id="lpan:LPMP_240980"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240015800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_240980"/>
    <dbReference type="eggNOG" id="ENOG502SIN6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267432at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="561" mass="59975" checksum="D4C0BAED0E5079E0" modified="2014-11-26" version="1">MKKQDDLVETYTVVARPYMRSGTERAWVHHFPLYSHPMFRAALRNEEAVRNAFLEQSDRIDPLALDSALDHMVTQLMAQHLDQHEAKGSTPLNTSRKDLIVTDSQLHALLAEPTHAAPLPSRPQQPSSVLQPITPETIGALAPGAAQASSSPGLQGQFIPNQYCHTTYPPLHSYSDVRHRVAPPLRTQAGPLSGATSVLSSNKQDALKVVSVDALQQSALRNGEHVPNQSALRLPPLSASTTLTDSGEAKAKNAEIGASGNTTTPQHRPMASLYSLLPSLTASPGLKTSSVLLGTATSLRPSQSSLSFCEMDRRPGIGTGPVAQQSVDAQQLHRVPDAVFAAMDVYMDGNSCCIRRRHRVLTPNGNKDMSLPVNLSSLPGGRASAVGGSCFVFGCGSRITSISPTYIAAAQNKLPAPPPPRTAAEAKARCILEGQRRKQRLHGQQQHLGPDSYFLTGGGDAAQRSSSFAGPHGDPVTLPTEPLRSRHRKQSDSRHFNSAHSAVLPVAPPVTCSSIAVPRTASSPPSDLQTSLLFTLHDIAGESVYTQAVSSANRFANLRLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SCD0</accession>
    <name>A0A088SCD0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein kinase, putative</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_262490</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99361.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700068.1">
        <property type="nucleotide sequence ID" value="XM_010701766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SCD0"/>
    <dbReference type="GeneID" id="22576152"/>
    <dbReference type="KEGG" id="lpan:LPMP_262490"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260029600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_262490"/>
    <dbReference type="eggNOG" id="KOG0575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN99361.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="485" mass="54778" checksum="137FFF514D7BB0BD" modified="2026-01-28" version="2">MESSRSTGDLLTPGALWQEETAVLVCGGRRCGRRFNRLFCPKHHCRWCGRVYCDTCAPKRAMYKQQLLRKCNQCRLPVVFRHSWNARTGAMDCAPFECIIGYLTPRSITALLQSCYTMMSEFPVCGYPFYNSIQQRFPSFYPGAQIGRGTFGTVFKCEDRTATDRRRAILKCISKRTNLTYTRWIGALTELRILESVNHPNVAHLLGAFQTREDLVIVMEAGEGGTARRAAACMREYGQAATEAFTANIIEGVAAGLDYLYREKHIIHRDIKLDNIVLSADYSTPMIIDFGLAEFVVNEEGQWYVVGGTRNYAAPESIAAVANGHIDMKEPGITMHKGDLFSLGVVAYYVLSGQRPFHSRSFDKMHEEMRRGVACAGPLWDGISTDARELVQALLSYSPAQRPDYAAIKENAFITGRTPGVKSIQMQRNARLLLDEKETHAEWVTLEPSDVKEGADEWESEVLLPLSTSQRWYHAYLPRFSRFHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SDB2</accession>
    <name>A0A088SDB2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Dual-specificity protein phosphatase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_280820</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700423.1">
        <property type="nucleotide sequence ID" value="XM_010702121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SDB2"/>
    <dbReference type="GeneID" id="22576527"/>
    <dbReference type="KEGG" id="lpan:LPMP_280820"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280013600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_280820"/>
    <dbReference type="eggNOG" id="KOG1716">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10252009at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45948">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE DDB_G0269404-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45948:SF5">
        <property type="entry name" value="SPECIFICITY PROTEIN PHOSPHATASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="34"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="146"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN99716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="629" mass="69756" checksum="D61273414B9CC575" modified="2014-11-26" version="1">MESLLASLQWESEAVPLPGSHSTLPKDGLPPWQHISEVIPGLYLTCASEIADKTKCVAMGMSLVINMCGEDNVTKYRVFEKDEGATYAFRRVDSQENFFCELSTYCRAAATTSNAQRRVFVVTIPAEDTPTYSIDQHFMECAVLMEIVLQSRKNYKEVREEDYTAVPAVAVHCMVGVSRSASIVAAYFIKKYGVSHVDAIRLIRCTRPIVQPNLGFQRQLSFWETLRSYRIVDEWSAKVLAMETKNKSNLLDIANTMLPIILRTHKCETDRRYFGSLIKNAAATEAELHSVYRELRSIVAADVDSEVYTDIPNYFSYVAEVVCSIDCAASAVLQYATDLCDSPSHNDAFYYRVVKDVAHSGFETDTFNTIRCFCSLFEAIYVKHLCVRDSGHPAVLSSRTGAAALPSACALSFPFLFLVAPYAEGFVQFSEWNDLVNEFETAGDALSAADLRQLKSKTVRLFLQFFFQSSCFEERSAAKESYTKLGFLQNDAEVLTFRAVESQLKTDGVSIASLESVVAVSQPADSHIAFLLLCKTLSGIVAFRLLLEAAEQFLSRTYSARLAESVPLADEFLPLSVIASAVVSLESAYTAAHCKPCKAREFFRGELSSLLKAGILNPTGVVALFQILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SDI8</accession>
    <name>A0A088SDI8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_281780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700518.1">
        <property type="nucleotide sequence ID" value="XM_010702216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SDI8"/>
    <dbReference type="GeneID" id="22576623"/>
    <dbReference type="KEGG" id="lpan:LPMP_281780"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280024200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_281780"/>
    <dbReference type="eggNOG" id="ENOG502QUUU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="246619at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="642" mass="69124" checksum="F799611514D1AEE7" modified="2014-11-26" version="1">MGVRQHDVQSALTQYMLRHFPEEVVLLPSGLLARRMLRTPVAPLKASTSGLGAAPTNADVPLASDDAALPSAGSTATPLDGSKVTGSFPATPGQQTSAPNVQSPLPPLSSCSSASVPHSSLNTPATHADRMAPPPPPTPQSNNWRYGSGGTGATMAGGGLLAPRATFGGASASNSLPSLASAGAAAVSEPESSTPAPLRSTLQVMEALVPYIPTFFVSIEAIEPTLPTEIQRLYDETSFRFYLKRFRHYIDTRAAHGSVEIRLRPDFDHPQRGHADARFAVGGFSGLGGSQCGAQPLRRPPRNSEANLIGLVAPQIPKEYTPLADVLQDVAPIVSRHPAFDPRLGVTGLLGKYPEYFQMAHGKLRARPYRVAPNSLDDRDASTSPLPSVFAKVLALVAEAAVGKDYRVSEERAAAAVSTVRLYSLLTQAEKVEVKAQCRSFPTFLRMHGKEIVVSADKMKVYKFLPEYEACVDTLLDERLRINSLRPDDPVLKIPAEMAPESNADWAVRELYDALPLMQCAELEEVLSLVPPAVRDALPCDLGAVQAVLDNYPEYFTTWPYPDDPSIIVVQRAKVEQPSLEKADIVRMVLPLIPQGGTTLASLQTRVPLALQRYFARHGTVATLSAMKDVFIISGDRIVRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SHR4</accession>
    <name>A0A088SHR4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_330890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702182.1">
        <property type="nucleotide sequence ID" value="XM_010703880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SHR4"/>
    <dbReference type="GeneID" id="22578242"/>
    <dbReference type="KEGG" id="lpan:LPMP_330890"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330013500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_330890"/>
    <dbReference type="eggNOG" id="ENOG502SHQT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273665at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="917" mass="100567" checksum="99E699157E9F77DB" modified="2014-11-26" version="1">MQLEGAHPGCFLSVSQVLCAQTETARNSAVGLSVTLPPLCAWGACADTGGADESCDPRHGSYHGRTGAGSSSRYGDVWAPIESYLTHLSGDITDTNDRGKSGMAPPDLSPPLCLVLRLFPDLTIAQLPILHRGNGKGSRAPLRARGSFITPHEYPLEAILGTEELWGSGADPRRVFRSAIDCLQELGRRLLPQLPLVLQLPTRLLVSQQFLHDLATLLICDGWRSVSFELPSTHQLYSCHAEGSSSGVPAASAAEATDVGATDTAWCRLPLLCTPWATLCRHPGLGRTLRQLRRHDVVPFHVLYSWAVAEMQLFNRLELSIVVDTTAPMPGEEALHAYLQSPSSVGRSAEELHRAPQQLPREFRSSTGVTLSSSQTDNDTDSTHRHVYMSENPMTTRRSEVDLFNGVNDAVRRRGWSGARREVDRADLDNAEKEWRLQKRLCTTSPSEMTTAVAHTPLASLENSGGLSLTLDAPPDHLRALIEKSIVDSDASSRPPLSQRQRLLQKVGQFMQRTIVEPPATASDSSAVPLSNPTCEDHENASLKQEAEELERLLREANDASDAAAASSEAEMMIAEMQWYMRASSQASSCNMENGAVERASCEPLPGYRGQSRKTNNAQDANPETTSNAWSAFPGYWSCMHALVEEVTHATLLWTAPTFNKAAVHAWTAAYHASQLPSAGHGEAPLSRDAPLPLIIPIYMPVQSAMHAEVERLLREGRWFKQPPLLQSREEAIALHTWLPASLNVALADALSRMPSDYQSHERRRLLHDHQRLRREGARAARRVGSVIEPAAISPTSSAPSGDEDELYPVRIRIHQEARPLYLLTPAQVERRESQVFKEAAAACAPSGEGEAQLSTCVSEANSAFAQAVEEYYRVTSPTCNAVLAHRMPSMPFLQVPTPGLSIDKLYRSWRCLSSWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SKZ2</accession>
    <name>A0A088SKZ2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_353400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703277.1">
        <property type="nucleotide sequence ID" value="XM_010704975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SKZ2"/>
    <dbReference type="GeneID" id="22579369"/>
    <dbReference type="KEGG" id="lpan:LPMP_353400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350041900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_353400"/>
    <dbReference type="eggNOG" id="ENOG502S2YB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275999at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="154" mass="17575" checksum="DB1651BE62AA3FBC" modified="2014-11-26" version="1">MLRRSPGRHIKPFLHAFSPGVRPSEKGMLYRNNYMNAHAQVASIPNTHRSYRERTTFLLLLIPEQIFLTIMILVTGCVAVTVVFRQQPFTTTVNKDRWLSGGMNPHEQYERNATMSQIFEMHKAAIDNTRAELTQPEVFSAPSGYHSPSGLYNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SL44</accession>
    <name>A0A088SL44_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_353920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703327.1">
        <property type="nucleotide sequence ID" value="XM_010705025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SL44"/>
    <dbReference type="GeneID" id="22579420"/>
    <dbReference type="KEGG" id="lpan:LPMP_353920"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350047200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_353920"/>
    <dbReference type="eggNOG" id="ENOG502SP5H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272843at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO02527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="130" mass="14211" checksum="7D9A8DD41892A555" modified="2014-11-26" version="1">MSTASLSQSRGPSSSPSPATLHQLRCENAMLLKEKQFLTQAVASGPSTSARVNSVRYNADAVELKLLMAYQMASELHDAEGCKAAEMQMQQRVAEMVTKVNKLRQLLEMVQKDVQEVLEASGGWERQAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4M3</accession>
    <name>A0AC62A4M3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase M20/M25/M40, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3320410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="XUY36749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="472" mass="51182" checksum="D9528480A5A26E51" modified="2026-01-28" version="1">MGDCDWTVIQKAVGAEWDASIIPALSAYIEVPNQSPDFDPHWATNGLMEKAFHILIDWVKGQNLLGLSYEFMEVEGRTPFLLVEIAGTERTNNTVLMYGHMDKQPPLRPWAEGLDPHKAVMRDGKLYGRGAADDGYAIFSAITSVSVLQRHGIPHGRVVVVIEACEESGSFDLDYYMAQCKERIGNVDLMVCLDSGSLNYDQLWLTTSLRGVTGGVLNVQTLTEAMHSGVAGGVVPDTFRIARELLDRVEDSKTGTVLLPEAHCEIPDHVAKSMVSMKSVPFKQQFAMADGVSAEPGDNVELALRNFWKPSLTVTGANLPEPQIAGNVIRTLTSLKLSLRLPPLVDSGKATQAMAKLLTTNPPYGAKVWFEPEVPGDGCATPELKPWLSNALNEGSKMAYGNPLAYQGMGGAIPFISTLTKMYPQAQFIVTGVLGPKSNAHGPNEFLHVGYAKGLTLAISHVVAAHFLLAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A532</accession>
    <name>A0AC62A532_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UDP-galactose transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2420050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="XUY36894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="451" mass="49225" checksum="7591B09AE9CF19EF" modified="2026-01-28" version="1">MRSFPWSMRARRYMPNFNAMALVLLAVQNAGYLILMKYAQQADKHHTLAAGGAEPEGGEAQVVIFKASHFLTTTEVVKLILSLLWCIVDEVRAMQQESAIAEADTTPATLLRVKEAGRGSALKNAASPNGVVDEPCRLSPALGDAAEDIDAECVVAVVSLRVLVTRKRFAAVFVSRMRHAIGLDHKYKEALLMVAPAIIYAIQGLLLIYAIELLDPTVFQVLYQVRIMFLAAMMGVVLDFRLSPIRWVALVLLMFGITLAQVSAQSTRTETTIGKADEAVQSEMGKTAAAEKVSSTWSIEGTLAVLAGAFLSALSGVFMEFVVKKRCNQFHLSARNIHLAFFSVVYFLVVFLCEIWRPEVAVGGLAEFISTFFDGFTSLVWTLVAVQAVGGILVALVVRYCDNIVKSFSTAFAIVLNGMASVFLFHTALNATFLVGAFLVLCSIIMYSLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5S1</accession>
    <name>A0AC62A5S1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">60S ribosomal protein L28, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1120030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="XUY36966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="147" mass="16214" checksum="1F8B5B3581ED17F3" modified="2026-01-28" version="1">MSHSADLQWILVRQSSRFLQKRGGIRMSNDPFNNNGSWTKRQSGFLNGKAAVVKPAKAGMICVTVKDGSSNNKPRLAYKKVVQAAGVKASDVSRAVAAVRPDLASVAFRRARRMARIASRTTKVAAARKARSEKIRFSRKCVRAKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5T6</accession>
    <name>A0AC62A5T6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1820060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="XUY37117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="362" mass="39418" checksum="28E325D73C75E96D" modified="2026-01-28" version="1">MLSWSGRASVVRCTSVAAHCPAAATSQLLFYSSQRNGHGARDPHRDSLLPHAASTAAPAPAAVHTQRARARKALKRTSLLEQLLDCNGGKSGTEDLSKVPSGDGLVASATAASPSVPVLHPAAAMSPAYITSSEFASAPIPKQPQHVWPPHRTHSAAAAAPLPSPAASAELQRQQQALRGAFTHARQHHNVRLAKDPGVYRAECRAFRQAHQGRSPTQQEVSRIVAVPLAPVAALKTLAHVNGKRSSLHATTEAAVMLHNAVVKNELVKSNTPQLVRCLRCFHVYAARPRTLWGGEVEQSFTEYEKAQKAQQHQRTAPGKRARSVDQRRRAYEDDPICCPKCRSPRAQWMMEYVHHHTHERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5Z3</accession>
    <name>A0AC62A5Z3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amastin-like surface protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2020730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="190" mass="21197" checksum="2AF05B4272D9C9D8" modified="2026-01-28" version="1">MFATPIDMFVLKPHFRSGSTPAVTLWGLKNGGFGNGNSQSLEELWSRCLNRLMRFRTAQALAIVTIVLYGSAFALGVTMLFCCSWLRFVCVALNIVGAITLGVVWGLMVVTYRTDDSRDCVRESFLSTYGAGFVLFVIAWVLDILNIFVLLLPLPVTVFRELDGANDKSEKTSKGESEERSTQQEDEEYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6E0</accession>
    <name>A0AC62A6E0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0920230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="XUY37340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="345" mass="38466" checksum="4CB0485DA9AE7F8B" modified="2026-01-28" version="1">MPTKPINAVCTMATRECVAELALFHRALRTFHPTLPLHLGCSSEVRDAAEAATDATAPLRALRDDAHVRWVPCLDQYGPVISRTEMERQRGVWYPARHTDFMMEKANLMELAMMTTKASTPTVAFLDCDITLLRELPCVPAAAAVALSPHWIREADEAVFGAFNGGYVVASTPEVLWEWRRATQTSRYFDQASLEHVAAIFERRALLHQLPPQHNYGFWRLLQPRCGSVLDEAKRFSIAPAPPSGSGQQPAATVVHYDGAPLCSVHAHFFAPNPPRDVRLFCAVLRRWLGRCRPACAAALAPPGGRWAAPAPRAPARDPPRSAQNNRKERREASTHRRRSDKPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6K7</accession>
    <name>A0AC62A6K7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amastin-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0820200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="XUY37300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="187" mass="20790" checksum="A795E9BBC66A4B78" modified="2026-01-28" version="1">MELTLALLLYAVLQLIAFLFVLVGTPIDMFRSRDEAPFGNTPCITLWGFKDKCYSGMLSQNSDDLWSPCPRRRDSFRAAQAFAIISILVYGLAALFGFIMLCRCPWLRVVCLVLNVTGAVTLCIVWASMVVAYSTLDRPCFGLRSRNNFGSGFVLLVLAWCLDIINMVFLLLPSQAKDPSGIADTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHD6</accession>
    <name>A0A088RHD6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_010550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009370">
        <property type="protein sequence ID" value="AIN95155.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696697.1">
        <property type="nucleotide sequence ID" value="XM_010698395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHD6"/>
    <dbReference type="GeneID" id="22571784"/>
    <dbReference type="KEGG" id="lpan:LPMP_010550"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_010005800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_010550"/>
    <dbReference type="eggNOG" id="ENOG502SCBV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267257at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13917">
        <property type="entry name" value="zf-CCHC_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95155.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="738" mass="77964" checksum="43387C3EED8ACF24" modified="2026-01-28" version="2">MRGESRTSAVRALGWYSSRSCSWRLSSLGALSEAAAFDVLGVTAKGGWQWWSVVGSASRRSAASLVACMHVCVWGGVVCALSLFDCLCSHHLARLLTTSRAQPPRPTPPPCTQPCLVSSGHTHTGKEADHRLFRVSSPVNEGSLDSFLRRRAWTNQSDRNARARARESEVCGVRGKGKVKGIFLPVCVCKPACGREAKAERSGGSTAPLPRIPTNVCTRQTGPLRILFGSAQPRHLPLAPSRSRSSHPLPLLFLIRSLFLSHRSPPCGTCAQIYSQVLQPDRVLSHEERTHERGTPIMAKTSASHAMHPPNAIAAAATNTSAATTPTPSFLVYPVPSIADESFLQLIFRNTVKRSLFLGFGRGRFAVTELTSATVAAEVEAIIHKAAVAAVGQQDSVVAPRDANGTAAEVEATHSALERMADDDALEHMALADLFAPPPRSPSHASASVHRQEHQPSSSSTNGSGSAAAGGESNDFSHIPYLVWRDKPVHVVVSGVRVEDFYSSGGVVPVHHVKRSADEEGKCNSKPKRPSTVKRPREDGADSTAELPPSSSRAANRRAVVANAAMIAAAAATAPKSLFPKNCCQKCGSADHFTRHCDGSGAATGPSASAAADADTGSPRTSSATAALPFPAVAKTTVVSSFPKNCCQKCGSADHFTRHCTSSSSSNSASVSAVPSSFVTAHANKKPDREAFSATVVASTPLPAKTKAKAVVQRTSKDQCRYCGSEAHLSRHCPSKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHT9</accession>
    <name>A0A088RHT9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA topoisomerase type IB small subunit</fullName>
            <ecNumber evidence="4">5.6.2.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_040080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type IB topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="4"/>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="AIN95335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703657.1">
        <property type="nucleotide sequence ID" value="XM_010705355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHT9"/>
    <dbReference type="GeneID" id="22571967"/>
    <dbReference type="KEGG" id="lpan:LPMP_040080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040006500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_040080"/>
    <dbReference type="eggNOG" id="KOG0981">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="47179at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025834">
        <property type="entry name" value="TopoI_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014727">
        <property type="entry name" value="TopoI_cat_a/b-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018521">
        <property type="entry name" value="TopoIB_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051062">
        <property type="entry name" value="Topoisomerase_IB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290">
        <property type="entry name" value="DNA TOPOISOMERASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290:SF18">
        <property type="entry name" value="DNA TOPOISOMERASE TYPE IB SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14370">
        <property type="entry name" value="Topo_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00176">
        <property type="entry name" value="TOPO_IB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52038">
        <property type="entry name" value="TOPO_IB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Topoisomerase I C-terminal" evidence="3">
        <location>
            <begin position="202"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="1">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN95335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="269" mass="29006" checksum="66966CA6D162183B" modified="2014-11-26" version="1">MQPTQSPPVAPPTVPAAAPKKTPIDMSSLKLKMSPSVRATLAAAGVLGQRPRLIEATDEDALLKLKPMKTMVSPVKIAVAPAATMAPPPKVRRVERSSSSSSSSSSSSGSSSSSSDDDSSSEDSSDSNSSSYSSYDRSSLSSESGVSKKEESLFDIAQSQGLVNKEILMQEEEEVPTLVPPRPPVVRSFPNDIGKALVRYRERLNREENVIRIKDDNKAVSLGTSKINYIDPRIVCSWAKAQDVPISKVFSATILKKFPWAMSAENFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RI16</accession>
    <name>A0A088RI16_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_060430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703924.1">
        <property type="nucleotide sequence ID" value="XM_010705622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RI16"/>
    <dbReference type="GeneID" id="22572249"/>
    <dbReference type="KEGG" id="lpan:LPMP_060430"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060010000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_060430"/>
    <dbReference type="eggNOG" id="ENOG502RUBE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266971at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="220"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="474"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="587"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="728"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="902"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="502"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="518"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="528"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="627"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="650"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="733"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="910"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="933"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="947"/>
            <end position="959"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="959" mass="101092" checksum="CBCEAFBD1CAC377B" modified="2014-11-26" version="1">MLHEAHPTYDAAPLAGFDTADAVAGVMLTSIGSAYSPCQSISPVRQQQQHQQRMLHRCLSSSGSYIAAVRCSSTLPVPQGSVGSNPLSPKPAAGAEGSATRPQLPFAQVAAAAAAGWGDHEYSLHQSHQQEKFPLTPAAEDFVHEILAMNTLAMEQCYAAVAAGGGAAAVVGAAIANSAPSTATAAASEEPMRILGEAYMRVDETFAQDIPALLLDELKTTTLNNMGVVECNRGQPRQALSHFEAARQLEENNGMASPSIALNMCAAYNALRMFDKATAAALEAIDMLRSLELQRRRNRRLTAAAAASLDGRGGGAMDSAKDGDTSTMDLLLEAAAAPKIADSQNDALWGAAWNNLAVAQINTARGSKDTSEYTNALSLFQNAMRATQELLGMQHPMSKAVVVTFRSVRRAFRKYGAFKQHRSLLRAPLPPVDPREQEWEEAQGEVMPGHTRHGTLLQQRQQLTITFRGEVTGGQKKVERLDSTPYPGAVAHPYQRQQRMEGTSSGRGTTAAAATGSRRCRSSKGRQPKTQTGTSQLLRNMPLSSTLSLASAVYGNPHPLLYSPPPSGQCRESAPLFFPDSTRMAFNQYDGPVATDSSHQSHDQGQHGHPISKRGPATYKDMRMRSKSGTTGNHLSQTAPSSSRSYVQGSAASAAAASSPPQPTRPPVAKVLPPIGVSASTGAAAVTTAAFAEWGKGHGTAPGVVPFKHATSLVSDTFNSATITPVFMHHPPQRSSQMASSAPYRSTRTSPLAGVHSGPAATAHLHQSKMLLLATPSSTVGPTTTTTTTYYPLEVPSGTVASSAGHRELMTTSVTPPPTIADTGDPSAGTHELFRGMWVTADPHYVHRGPRVFGRPAYYTIATTLDVTEDGVSGDGSATGAGTGATALTTWTDSTPCPVLPTLTYSSSGSEEDNSIVGEGGDEYDAPDVQHRTSVSTDAKSSSVSSLTNKLAETSRMTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIP0</accession>
    <name>A0A088RIP0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Small ubiquitin protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_080480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="AIN95857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704179.1">
        <property type="nucleotide sequence ID" value="XM_010705877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIP0"/>
    <dbReference type="GeneID" id="22572510"/>
    <dbReference type="KEGG" id="lpan:LPMP_080480"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_080480"/>
    <dbReference type="eggNOG" id="KOG1769">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="442921at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd16116">
        <property type="entry name" value="Ubl_Smt3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000202">
        <property type="entry name" value="Small ubiquitin-related modifier I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10562">
        <property type="entry name" value="SMALL UBIQUITIN-RELATED MODIFIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="34"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="117" mass="12492" checksum="B15F2B9A345D9034" modified="2014-11-26" version="1">MENQGHNNQDPEGPTNNEAPAPVKAEAAAAVSAQQISLKVVNADGAEMFFKIKRGTQLKKLIDAYCKKQGISRGSVRFLFDGAPIDESKTPEDLGMEDDDVIDAMVEQTGGSGVGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIR2</accession>
    <name>A0A088RIR2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxidation resistance protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_060910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703972.1">
        <property type="nucleotide sequence ID" value="XM_010705670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIR2"/>
    <dbReference type="GeneID" id="22572297"/>
    <dbReference type="KEGG" id="lpan:LPMP_060910"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060015300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_060910"/>
    <dbReference type="eggNOG" id="ENOG502S3Q0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26679at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF62">
        <property type="entry name" value="MUSTARD, ISOFORM V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="6">
        <location>
            <begin position="137"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="307"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="546"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="308"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN95650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="660" mass="71064" checksum="FA85AC19EE3D991F" modified="2014-11-26" version="1">MSLFSLNASSLPVPALTCSQEWGGASTGVSLPITPPCVARRILPLFPLPGCHVYDAHRNCFQYRPDVQRKLIEAAQRFERRRRHRTGQNAGDSAAATVEADAAALSKADVAVDRMSCRCALDATKLFATLEDMPNPPLPLSRCELHEVLLALPPSWQNYPWRLCFDTATDGFSLSSLYRRMEVVEAKQSQVKTVTFGLFFAHSREDATLLNASLTDSLSASSAKASCIMSPGISGTPHSLREAHCPRRMRQGAAHDTPPHCVLGCFTPEVPCLGRHTANIYFGSPDTFVFRLDQLSCTPSRGAWMATDMKRRQQQEEQQHPQRGSNVADTLDSESLKRSAADPHTSASGTAATALAAAPAYGYARLAVADDGDAGVPVPMPSRMTIEHPLCPTRTADKPTMNSALLLSASEAALLRNSSPPRTDLVSLGHAVDISRAFDAPGAVLSSPVSRRRWPLRPARPAQVVPLAPLLEKFTWCGHANNKRFVVCNSHFFAIGGGKNGAALYVDETLQYGTSSLWCETFNAPCLFDPRVGGAKASPASSSILSFSSGDSGPRDDHVTARGGSARLTSGLPHMEFTISRVVWFSLTEDKRNRRTMRAIDALLTCEEAQRCGCGRCGGDGDNDATSFDPLSTAATMAAVPPSASTFLHRCDLLPCAVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJH6</accession>
    <name>A0A088RJH6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_090440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN95960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704282.1">
        <property type="nucleotide sequence ID" value="XM_010705980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJH6"/>
    <dbReference type="GeneID" id="22572614"/>
    <dbReference type="KEGG" id="lpan:LPMP_090440"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090009600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_090440"/>
    <dbReference type="eggNOG" id="ENOG502RYD8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.200">
        <property type="entry name" value="Plus-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004343">
        <property type="entry name" value="Plus-3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036128">
        <property type="entry name" value="Plus3-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03126">
        <property type="entry name" value="Plus-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00719">
        <property type="entry name" value="Plus3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159042">
        <property type="entry name" value="Plus3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="413"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="165"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="238"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="254"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN95960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="460" mass="50889" checksum="52E6E0D6AC3AEC30" modified="2014-11-26" version="1">MISEEDSRLFEAAKRAQVSRNTAIYVIENVDSSRTLSGAFVRVLLEMPTRREGYVVARIHSTTAGEVYSGFSTNPTQTTNVYLMLELPPPLAAINGVQYQLNSVSNSSMGEGEFREWLQMIRNEPTLREPTVQELSEVTARLHPYEANRHRANSNVNANSNRSQAIHGQAGAANASRSVPHSQVMPRQQQQQRALSNHGATRQHRQSLSASSPTALVPPQTQDSHPIVGSNDAPLRRSSAAMSEASSSGAIISTDGSVSPASRNGSNRFVRQGTMMARDYNRNPRQDGQASYEMSDAEVQAMGTYTPATCNQQQQQQRIALPRPQGSSASGPAMAATASFMARGTADQVIETEDEEMERRLRKDIMNHLAQECVLFPKDAQGYKLSRLRLLERDMIEYLQHVRDEIQGKQENCIVCMDHAPTVILLPCKHKVMCRLCAPSCPNCPVCRSSISEMFEPEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJJ7</accession>
    <name>A0A088RJJ7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_040070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="AIN95334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703656.1">
        <property type="nucleotide sequence ID" value="XM_010705354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJJ7"/>
    <dbReference type="GeneID" id="22571966"/>
    <dbReference type="KEGG" id="lpan:LPMP_040070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040006400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_040070"/>
    <dbReference type="eggNOG" id="ENOG502SDC7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="310405at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="512"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="548" mass="61385" checksum="613A6E5F3AFB185D" modified="2014-11-26" version="1">MSSSEIIVERGASYPEAQSMDNEMLAQHEECEESPQDPQATKAAIPYCESTAEEEAHSQRHEEKESSEEKESSEEEERSEEELGGTYKPTDISADRYSKELELGKVVAAACSANEELEEVKRLKVTGAASHAEAAPPEVAKTARPCEVSKPNKVKKSGNHAKKAKTAGPPAAPRKKRLAGKVSIDNVEHRPPVPEGVNTPRSVALCREYGVKPCELAPYDKSHFTGSGVSDEVAELRYQSYEKRRCARMAQLVPAYRRKITPGSDSVPVPDTKRHPRSTEEISTQSTATEKAAAHQWKPMDEDAAMQRQFETQHQRLLDQERCKRVTSGYDSDGHRRSSHPRAGQSYGASVLSAGSARSPGRYSVGMSVSARPTVDLPYSATKIYSASIAESRPLTHSEVFMIDEINEREAHRNYTQERAFVIQENTQLMHVERELMRAQRSCVSVRKRAEERRKMQEEMRKRTLARQKEAAARRERLVMERQMRVKENIAEKESRIHATNPYIAFMSRQMSSFSTRRNSSNSPLQGASTSNSQEQSAETEEATMGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJK6</accession>
    <name>A0A088RJK6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA pseudouridylate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_040220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="AIN95349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703671.1">
        <property type="nucleotide sequence ID" value="XM_010705369.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22571981"/>
    <dbReference type="KEGG" id="lpan:LPMP_040220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040008000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_040220"/>
    <dbReference type="eggNOG" id="ENOG502S1RD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="418349at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF77">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="2">
        <location>
            <begin position="974"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="659"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="755"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1013"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1321"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="767"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1333"/>
            <end position="1342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1342" mass="142428" checksum="78DE412702A90FD5" modified="2014-11-26" version="1">MVSLHRVGGGDSVATLADIGYEEGADSHTTQNHLGFSPPTAPTANTPLKAGGAVSLTERRMLEHYAVLLHDIRVAATQVATSDYHRFYASAVEELLTASASRGGRGAVSVPRSVVWQDAAAPKDSGKGGEDATAQAERRLAAWASSWYTELKQWHARHSTHAPGTSNVFDAQQSLLNGELGQDVLVGREDVVGTREEDKSMAALLLQGQWQVAIDSLLAGDATQPPFASAAPIEPHSTFSTVPQQLSVAELFSTASVLHRHRVPWRPSPQRGSANSSSSTLPPLPRRLALAPVTPTELRLLQYPPSPGLRVLSHLTASEEQCGECQAKSAGNRVKVAPSQLLEAAAAAEVAAGRATGTPPTCVVRLRRRLWVLQHLPRHLPASLVRFQEPRRPSKRAGGGSCCKGPNRTMPRAYLLRSHALEKLPWYTLCVLGEVLEVGGKDNLTVATVLRNARTHTCAALFLNVPADYAALHDYVHTLFLTLGSSMVARAVATQQKQQGRSDSDKAVSVFEGAFAQTAIALLQPPPPEAYAAAGLSARPISASGNATSLLARSSSAQARTPSTDITDVHVVSPQVFCHLCAAVQDWRNYHLSLYCETLSQIADSDGVALRELARVLEVQPHSEEELQEKAAVVLAPESAAAVVTALLLQRLGQVSRPSASSLSTTDRAPLPSLPDTPRTIAPHPSVGCHPQATSPSPPPLPQVLYFIAPHDKAHAVANYFKGIFHRSFFKRVVTAAAAAAAKEEAVVGAAVTPGLKKDPRQPRDYAAPISATPTTTATSPRTAEEGNGSASAPPALVLPPAEWDRNAAARLVGRTLRRLDRYPTRTTEAFFARYVRGDDVDPKREGEEAASVAVAAATQSASTTVAPPLAMNLFVVSLQAAVDYWHDRHCRPVLDVPPTASCSPQQKGEQATFTAQSAATVPAVDSPASALVGTAAAATPASVEASLSKDDKDGLPDAIVLLASPPILPHGLHAVYKPAGVNCTLHAHYPSLVYPFLTCELPWRAGGVVTADGNDEHRDAGASSSSLPPSSPPSCVPVLRQQGLVNRIDVGTSGVVLVARNAAALHGATDTMIREHHIRKTYRALVQRWPPFSSSSSASTVPYSNDSAEVAPLFSVSPFLSPMASTVVCAPVYAAGATAASIRWRPALSLSHDCQLQLSARHSADTLSVSGAASTLSQSSSIPSSPCSLAHVHQQYATLHAALQDQRNAITCYRVLEYFASTGVAYVQVELRSGRRHQIRQHFAQLGFPLVGDARYHAGVAAGHSGTTFGMQRAALHAYAVNILATTSGDGQASDEEGPNRVVVQAALPADMHHALLALRKAEQGKSRRQRQQQQPQQHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJU0</accession>
    <name>A0A088RJU0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_100730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696796.1">
        <property type="nucleotide sequence ID" value="XM_010698494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJU0"/>
    <dbReference type="GeneID" id="22572810"/>
    <dbReference type="KEGG" id="lpan:LPMP_100730"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100013700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_100730"/>
    <dbReference type="eggNOG" id="ENOG502QV8K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267902at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="726"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="329"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="732"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="844"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="869"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="910"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="937"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="964"/>
            <end position="979"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1066" mass="114079" checksum="030205A649022BE4" modified="2014-11-26" version="1">MTPKRKLKAVGGNAECLDVLLSSEQYQSEKDARELRLCGVATVGQWKEQPDRVQLSAYARGLLETAYNRLARHRHHSRNDEVVAWLTRAIQRAVADELMAPKRLTDGTAMTMPSTSPFLIDLKVPAVTAAGKVPVDAAAGHHARSAAQSAATATATQGNSSEGSMAVAYPSGNSVQNEAADANAAARRRGPRQRSVVSGAMSKVPVAAAVEEDGAAESEELTDTIDGDAEEGGEEVENEEMAELMAEAEVSPAKRAVASPSPPPFPAAAVTPPGRHNNKKAPEAAPTAPRRQQHHQPPPREEVEAADADEDDEELVEEVEEVEEEEAADMTAPPSSTSAAQPPSPPAPAAPPAPPATAVVGAAAAAERRERLVRLAELMMKQFNTADGYLHPSNKAEREAQEARGDILVLDEDTAQVDPLAVFSAYHAATITDADPVAVRALKTIWTSYNKHQMALEEAKDDTSIEFYKRESVNALLYGSVLMRALAREEQVVVLEGTLLPPYGFPLVSSDTRPFAVFAAAGGSSSSSTMAVTDMTSGKVLTALQAYKVLFSSKEKRYSPFRPAIDQSAGCSVVCLSGTTLHLYYTSTKDRIVEEEVRLPFAEVMLGVLHLLRHKVLPRVNVVHYHLIATKMVDPSDSADFMLRSTATIDLTNPFTKEELARLCALATPLGMADEMAEFRCIDDLVIEIEDASGASVVHSLLHNREDLEATLTATLAQLLPEDGDSAAGTEEAAEDAEEENEVVVEDEEEAEAAPPPPPPPSRKLRGPAAAPAPSPSPGRSSRRRAVHEENEEETVRMEDEEVAEVVQARPTRAKHRQPAGTPLPTSEAVLEEVIHRQWQQQHGAGKAGAAASAAPNSTAAVQHRDDDGAATEEEEGDFDEELEEVDELEEEAAEPPSARALVRSSVPHAPAAPGAGAASRAQRSSRAAAAAAADDKEYEDDGAEEMEEEEEIEVVAPPMTQRAPAGRRAVPVAAASAGPSPPPPAPAQTVRRALQVNDVGQALQVRTRRGTRRLTARARAPPPVVHEGFEKAAAAVAEGAPEVEAAAEVDEDQWFRRRPKRRYFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJY9</accession>
    <name>A0A088RJY9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Monocarboxylate transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_050470</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="AIN95489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703811.1">
        <property type="nucleotide sequence ID" value="XM_010705509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJY9"/>
    <dbReference type="GeneID" id="22572125"/>
    <dbReference type="KEGG" id="lpan:LPMP_050470"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_050009400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_050470"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052983">
        <property type="entry name" value="MFS_Riboflavin_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43385">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER RIBJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43385:SF1">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER RIBJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="501"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN95489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="542" mass="58922" checksum="02B540E307BF65D2" modified="2014-11-26" version="1">MKIFEVWKRVNRSITHRPPDHWIGYLVAISGALMQMMSYGIDNSFSIFSNSMQNDPSLGYPSATTVSFGNSVSLGLSPVFGVFAGFLVDRVPPRVMMLTSTVMLFAALWLSSSFAKSSPEVTASFSLLASISSAFMLSPGAAATGSWFRRRLGLGQGINFSGGGVGSAVVPAVLGSLVDVYGWRHTFRLMSAFCSIGLVGTILSCRRHPIEDDIDIEEHAHSHSEPAHTSNRRGDNLSEEGDNIVLAVTAETDKKVTSSQTTQMIQPMSAEAEKAASHCNENMSELVDRHHQQQQTPQNGKEALGTRVCGVEDLIQDMHVRRLTWREIIRVFLSLRFLTHFFMFAIYGWAFYGLIYMTVPYVSSMGSAGTVYENVTAISTSKASTVFTFWGVFQIIGSILVGGMASFTDDALAYTICAAVGGVATSLLVFCRSYAAFAVCLSVIGFCTAGIFAMMPALIAKDFHGPNLGLFMGSVFVAACLGGFSAPPIQAQLNSRYHGNYSYGCVFISCCMTLPGVLCYLLLWPEKQSRVGRVVKRMLRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RK12</accession>
    <name>A0A088RK12_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Vta1/callose synthase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_050720</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VTA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="AIN95514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703836.1">
        <property type="nucleotide sequence ID" value="XM_010705534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RK12"/>
    <dbReference type="GeneID" id="22572150"/>
    <dbReference type="KEGG" id="lpan:LPMP_050720"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_050011800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_050720"/>
    <dbReference type="eggNOG" id="KOG0917">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="391137at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.270">
        <property type="entry name" value="Vacuolar protein sorting-associated protein vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044538">
        <property type="entry name" value="Vta1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039431">
        <property type="entry name" value="Vta1/CALS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023175">
        <property type="entry name" value="Vta1/CALS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041212">
        <property type="entry name" value="Vta1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04652">
        <property type="entry name" value="Vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18097">
        <property type="entry name" value="Vta1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vta1/callose synthase N-terminal" evidence="10">
        <location>
            <begin position="18"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Vta1 C-terminal" evidence="11">
        <location>
            <begin position="326"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="200"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="229"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN95514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="39556" checksum="05DE7038D4D921B2" modified="2014-11-26" version="1">MSSVSLLEKVPQPWAPLVRPFLQRSHEFENKEPLVAYYLRTHVAFLCMRLRKKEDKAGTAFLMTLLDALEASKTQLSAQLHGTDGRTVLTKFALVLFARADDAERTGNASMAIVRMFYTASVLLEATAQFTEDGAMDSIAAQKCKYAKYIAARMKKALDRKEPYVSPNKLEAVDSDAAGDGSTANGAGQAATFTTVPASCFTRPTSLPTSTSSWTPTPSTGQDNSRAPPYAPPPAMLKLDTPPPDYTYVANTQGSSNISAQPPPKKNMSATPKPQQPPQQQQQRQRLSTSHSTTPISSSSQQQQQLCVTPPNAGGVSATNFKPSVDQMIDAQKFASQAVSALQFYDYDTAKQQLVAALRVLNGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RK73</accession>
    <name>A0A088RK73_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_111240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696971.1">
        <property type="nucleotide sequence ID" value="XM_010698669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RK73"/>
    <dbReference type="GeneID" id="22572989"/>
    <dbReference type="KEGG" id="lpan:LPMP_111240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_110016800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_111240"/>
    <dbReference type="eggNOG" id="ENOG502S7AW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264736at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN96318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="192" mass="21689" checksum="58CC530C13103F49" modified="2014-11-26" version="1">MSSTSPALLTEVEVRELSTAEIRVNLERCSRLISQPTLLARLRDGGEGIRRRSELFTKELERRRTVQAVNANVNAHLVSPTLIETLKRENEAALLTESTPQFTDVAKEMGLKYKDQRVDVEATVRRMYEGALSEAEIQRILQGVPFGFFLTYAETCEMERQLAREARKAELRKLAAQAARHRDTPQVSGTGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKL8</accession>
    <name>A0A088RKL8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_120470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009381">
        <property type="protein sequence ID" value="AIN96375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697028.1">
        <property type="nucleotide sequence ID" value="XM_010698726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKL8"/>
    <dbReference type="GeneID" id="22573053"/>
    <dbReference type="KEGG" id="lpan:LPMP_120470"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_120009600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_120470"/>
    <dbReference type="eggNOG" id="ENOG502SHB9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268048at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="689"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="781" mass="82253" checksum="FAD745889BA647FC" modified="2014-11-26" version="1">MHPLNTTITNTILSNRGSGPHQLRSKAAGQHCRRHHSFCRHSPWKAKGRACRHSDHRTSGIFTYRHLTVAATAPTCMSDAHDSASAAQHHVFLSLPFTAIFHPLSVLPTLRRRRLPKLALSSAHMPSILPVSQGNGSGSSEALLLEHTSTPPTSFLPLGAEALRLFDMHSFNDNGSQPSSDPASEGVESHHRGVRTLQWLSEGALAAPAESPTANVLPSAPSHDDVSGLSDATDAAVRASHFFVPTAATTLASTESPARCVGVLSSPLPPAFALPIVLPATPLGKDNLSCPSHSYSCSMSIPSSQLAFSPFPHRLSTLRPTMVACDLAHGIEQEAVQRRHSQSALPNTVAHELLLSTGCTAEPAMSAVLSAARRNSSYISGTTMQGSFSITEDGVGGSDGGVTATAETPLMQFNTSRGTTFSGIVASTATTTASTTPYTSPSLTATRRCSSASALMEHTATFLNKNCISVNAGAAAAAEAALLSTPSQSPLCPPYAFSATASEMQSNGNEDNGEAAATAVSMAVGSAIPSVCRLLTTPATGARREHLFWCPSSSSDVNLQSRRTAEYDKAMRAVQRQEVWAEKTTAGREELRRQLEAHVFAKHHRWAERLCKDAPARQLLLTPSLPEQKLLSAEVVLISDDGKSSAHSTAAATAITIAGGIPPPPASFPPLIGTPLSFMGYGRDTATLPKVHVPRSTPSEAPGDEQDAASVGSPVEREDVESSAVDEEAGLTQPQWRPSRGEARDSALLPLDTPRSRVSVSSWGSSLSYEMALLAAARMSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKV3</accession>
    <name>A0A088RKV3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_130350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697118.1">
        <property type="nucleotide sequence ID" value="XM_010698816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKV3"/>
    <dbReference type="GeneID" id="22573145"/>
    <dbReference type="KEGG" id="lpan:LPMP_130350"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_130350"/>
    <dbReference type="eggNOG" id="ENOG502QU2Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="258593at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="497" mass="56175" checksum="E626DF68FF3733D4" modified="2014-11-26" version="1">MVSGLVEFEILRGKNYPQTEDDPNPCTTQVTVAVVGALSGAILSAVQLSSIQQNSNAPFYNDKLNFKLEEASENVCFSITVSEHSRRKMPFVLFYGKQLIELSKLKSKQRFVIPLFPEEENNRQIEIGAEPLVLEKSRTEPLLSVSIQFTKDKILDTVDPYSDVDISGKDLSLDGSNQLVPEGNQYVWLRLKSDKKWTNSYQCELLVVWRSRAPLEAEPQGNTKPRKGTTGGMGGVAGEVDSARTLGDIITKKWCCHRTHQVLTRICLTAEKYGKKITDLTFTPREEIEFRTNKKERCVLLERICEEKLKYAGSNRLQDWLNRIWILFVTGVDNDPAGPRTLSYEVRKAVHDAQFTEEDAIILQACLLFSFIPSLKYEVCQALSESDYQVSPSEKRRELTGFEASQCMVTPSQRLFTHVFIFFVGPLLDTLTEAEIVKAAAEFKPAIWDAQQRIAEGAKSTIGHHRRNNDGSIVKGNGIRIDHLDKLGHRKQTPRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLV1</accession>
    <name>A0A088RLV1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_160440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN96918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697571.1">
        <property type="nucleotide sequence ID" value="XM_010699269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLV1"/>
    <dbReference type="GeneID" id="22573621"/>
    <dbReference type="KEGG" id="lpan:LPMP_160440"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160008600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_160440"/>
    <dbReference type="eggNOG" id="ENOG502S3DY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272784at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="184" mass="20226" checksum="1EBA00E51BCA7E5C" modified="2014-11-26" version="1">MRPQNAQEQRKKATKKKKPSRVRVTNKALESRQFSTVRLPRTSEVPAPRVDVNSMYKELACGCSDGTAPASARRSVSAASAAASPSSSLVFDPIVSDPMFTIVAKSKYWPPPLLEELHAKTGHDHGDGFDSYDRREDDRQARKERVRAIKGEVNHPRGKPRQNTIVKLSDGSSSDDDGDEHGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLY5</accession>
    <name>A0A088RLY5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_101150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696837.1">
        <property type="nucleotide sequence ID" value="XM_010698535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLY5"/>
    <dbReference type="GeneID" id="22572852"/>
    <dbReference type="KEGG" id="lpan:LPMP_101150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100018600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_101150"/>
    <dbReference type="eggNOG" id="ENOG502S322">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270336at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="133" mass="14428" checksum="14065B5880B06665" modified="2014-11-26" version="1">MIFLEKLKTIVGRSAGSRARKALTTSAGVAPPKFSEAWSQAKAITNKLFEEREWQCPCGHKFRAAGEWVACAPIYCEVPSCPNPKYYIDGPGRALLEANPSGVKLEEVVNSRGSVAPQEASFQKPGGVGSRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RM53</accession>
    <name>A0A088RM53_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_160510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN96925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697578.1">
        <property type="nucleotide sequence ID" value="XM_010699276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RM53"/>
    <dbReference type="GeneID" id="22573628"/>
    <dbReference type="KEGG" id="lpan:LPMP_160510"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160009200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_160510"/>
    <dbReference type="eggNOG" id="ENOG502RXQX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273828at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="545"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="625"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="665"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="689"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="743"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1217" mass="130101" checksum="909F3838BE2A4FAF" modified="2014-11-26" version="1">MNFAFPHFTRASTDNAYTQPPQKSLLELVVEAKGRLGLVPQRDAMKRPPSSSPFSHFSESDEEGEGADGGVNGAEARQDAVLTTRTSWVPPTYLLDYFFSGEFLSVFLSLHSISASRPVSMLVPPLLTVRDAQLHPLVEAGLSSILRNAAHSSSRQQRNRGSGDGRGGIWGGRGGRGGGRGGAFAGNLLRGGGEQGYMESHPGAANIGDPSISYWGATEQYQLQGSVLGADEGNVNGAAEPNVSRSAYLFSTDSQRRVDDHAVTQPAQLLLRGLQQIALPALLLGDHVLLSGPRGIGKRTAALLSTGANVLAFTSNADPSAAEETEAPPAPAEGEGEASADRSPAVAEEPACAFPAKAGVKQKEATESTGDAADAHPAPADPAAASSPASPPTPRALIVLSSYSEVLSAAHWLESVFGPAAFALYTFQKDEVALSPLLEVPTAEQPPAALDPGKGAYPSDALGHVGMMPAFSEITNGRRFIGPPLSLPFITDTVSATGAVCAPALLPTDPTQSDSAVLQAEATAPALAELAALVMDAVLPAVASGAAQGSAGERASGGDAKPKRRRHSEDEEESGDDASKQRGEKWSSCTHRRHHRHRSERDELESDTEETRREGRCEKHSSYSSHRHCRHSRHGDHSDRGEEAESQLGRSASGGGRHHRHHRHSEVDGDVRVKDRRPADDKERDSRRRSCHRRSSSHHHHSSSRSHSHLRHGRSDERLPRRWSSRHRHHRSSSHRGRHDEVTSSASFSPCSSPSAVTSPTSSLRCRLSGPPPLMLTNAEAALPLALDDSLAPPTGDELRVLALDTGAPPAVSTEAPVTPFADGAVVEELAMAAERLQEVAEEDPTAERSDMLRQRVPLLITTYQALQTVLGMVQGEASALPPLEHVRVALFANLERALMPPLKESFLHSWWLSLVNALDVECQFVVTADRMGREVRGFLDSTVIPDAGERLVHFDQRDASVWAMMNVQVRAVPVEVPVAASPPNSGNAGRPRISGSDIDAAKVAHLFSIITEHMSSADSHATRDGDVSVFAAHRGRQGARVVVICSARREQALVVTQLQGLLGDHEHDTHAAVVRVTERAELFRTSGAEVLVLTDAQLADPRVARDVQHCTDVDLILHFSLPRPVMTQLEKKEIIDLLAQRGRTILGNSRQFCARRWWSTAAVASAAGVGAASGAPNNALDFVPVKVECQLLMTEHNVHGRAGSCVMGALQEVSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RM92</accession>
    <name>A0A088RM92_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_111300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696977.1">
        <property type="nucleotide sequence ID" value="XM_010698675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RM92"/>
    <dbReference type="GeneID" id="22572995"/>
    <dbReference type="KEGG" id="lpan:LPMP_111300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_110017500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_111300"/>
    <dbReference type="eggNOG" id="ENOG502SHIE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="261737at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="100"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="200" mass="22252" checksum="562583C9E29571E2" modified="2014-11-26" version="1">MLRSEDGRVDVAVRRCRAWSAPAASLSHICRSRDGSFARGATRAITGDHAHPTLPSTIYRLFPTKTIFAVLDIPFTPMLTATCNGVRQAPDLPRAEAESLETLKTELLAAKNQIKLLNSANARSFHSYAALEAENAELRDASRRLREANEELKARLAQRNVEVDEHLHVICDLEKKLEELSCFRTPEHLAACKHLNGDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMC9</accession>
    <name>A0A088RMC9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_171240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697815.1">
        <property type="nucleotide sequence ID" value="XM_010699513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMC9"/>
    <dbReference type="GeneID" id="22573867"/>
    <dbReference type="KEGG" id="lpan:LPMP_171240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170018700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_171240"/>
    <dbReference type="eggNOG" id="ENOG502SUE8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="255969at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="67" mass="7900" checksum="E9A69AE61425E945" modified="2014-11-26" version="1">MAPFWTNVLNYTYARGFIRIPMVLALPIFFNKYVLYGYEGAFKRWNAGHNQVDIWNRLQEKVAADAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RME5</accession>
    <name>A0A088RME5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_180060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697840.1">
        <property type="nucleotide sequence ID" value="XM_010699538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RME5"/>
    <dbReference type="GeneID" id="22573896"/>
    <dbReference type="KEGG" id="lpan:LPMP_180060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180005700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_180060"/>
    <dbReference type="eggNOG" id="ENOG502RY3U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275385at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="18660" checksum="0E066F3C2D12C8B3" modified="2014-11-26" version="1">MLRRCTVSRMNRGHLAPTPSKYSDHPGMWGPGAGPVKDTLARRTMFYRMLVMNKIGSWTKPLRTNRARWIWRKTQLQLWKTFVMSMVFICVILFGNVWLSFVYHAYTVGPTTPVLERKVREHRVSKQIMQMVRERERHVTQEEEVKEARAIIDSQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMS4</accession>
    <name>A0A088RMS4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinetoplast polyadenylation/uridylation factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_180010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697836.1">
        <property type="nucleotide sequence ID" value="XM_010699534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMS4"/>
    <dbReference type="GeneID" id="22573891"/>
    <dbReference type="KEGG" id="lpan:LPMP_180010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180005200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_180010"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:002028">
        <property type="entry name" value="Kinetoplast polyadenylation/uridylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001190">
        <property type="entry name" value="Kinetoplast_polyadenylation/uridylation_factor_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45613:SF9">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR CCM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45613">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839010" evidence="2">
        <location>
            <begin position="17"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="389"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="702"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="920"/>
            <end position="954"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1002" mass="113249" checksum="DF1E07CECEFF7309" modified="2014-11-26" version="1">MLRWSPQLLRLRLAGAFACTAPLHSRTGAFQPFSQRDEDDLLQVVKTKPRHVLRYVRQQVWRSRKRELQFRNTVTHLMILLQEFLRRQLVDPANASQIVEGVLEECVKYAQHDMAHLLFRALLRFRKYGCVITVNSIRCLFESYRNNDSGELMYQLAQEMKDVPELRPLCIAAYLFANREADAEALREGLSLTELGSEDVLALISGYEKLRRVEKLQEILQAVSGMSTDKIRTEVCSALFRAFFKLDDDTSFTQTLQVALEHKLPLSADVYATALRHKMRHVTSVEEIPAIEEELKELGYVPDATGDSIVITAYARLLHFGDRGSEELMLAKVDTLLSSVASRIQQGDPDMDISAAHIRAVIRGYGAAGRPEAIKSAWKRMQFHSLTNDVRIYNELLKWFALMGNVKDVLATKREMESNGVSPDAVTYTWVFRALGKYYPRHVEEYYAEMQERRVRPDIHLYTTLLGIFGDLGQTNTVEALLSELRKREEAGTVQLTPITFAVLIRIHGGDLDRAKALYAEAQQRNASDHPHVQTSMLHALAIHKGSTAGDVDEFLKTIPTWSTDVYNVLLHMYGKRMDRDRFDATLNKMKSEAVAMNDVTFGTLITAFARWGEGEKVNEVIQLLKSHDGEISATFYSVLASSLSRMGNPEGVENAWEDLLASRLFPDTEVYNQFLSLYSRQNNMSKMQGVLDNMMKQVPPNPVTATTVLDMLGKSGRVSEMETLFDDMKSTPDTAPTSVTFHQVMNAYAKTGDVVKMGKIHEEFLEKGYTDNSVTYNILMDGHGRAKAYEQLEELRQKRSAAGIAMDDITYCIMISAYGRSRLGKDVQRLFDEVTKEENRALLTKRVVWSAIDAFCRCNATPGIQRCEELLRALGGEGGTLSASDYCGLIPYYCRMGQMEKVEDVVRLLHEKGEAEALTYNALNAIARGYARTGRFDKTVETLHQIRDRNWVPDAATALQLSAAFLKTGLHEQAQQIIEWRRQYAKVAGSGVVTAIEHSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RN11</accession>
    <name>A0A088RN11_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_181370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697971.1">
        <property type="nucleotide sequence ID" value="XM_010699669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RN11"/>
    <dbReference type="GeneID" id="22574027"/>
    <dbReference type="KEGG" id="lpan:LPMP_181370"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180016700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_181370"/>
    <dbReference type="eggNOG" id="ENOG502SJCW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267558at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="957"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="998"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="580"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="965"/>
            <end position="975"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1036" mass="107158" checksum="813A6969D40BEF9F" modified="2014-11-26" version="1">MMTHRESTDCSSATLPASMQTLLDRYTDRQLTQQERLVLAHATPRVRCEALRIFFEMNDAAAGLEYVLANGGASLNSHGDTSAKASLSSGAAATASTAVPLVAASKALKSLPINTLTATSAGAKLNTAAASDAKRPFAASAPNDNTALQDDARKPRGTGRTAVPASGSTAPSLVTSTRSCLRRTSAARRGESVCTLVTVSSMSSESSDGDNELRPTETPVKEEEVGADMPATVTLRYRGSRSSAVVASAAPIVPALALGTVLKQHDSISRSSPSARVAHSEYRPSVSPALTTTTVAANAQPRDVSPSVAPPPHTEPFSPATPKSGITGTAGTRGSAPVTPPPLPPTRHEGAGDDEEPRKTVAAKLTAYHANPTATLAASAPHPQQKHCVGFTDSKARTVLSAYRRGCTSSTFRHHHEDVGLAYTEPLCNHRSPSSSCTPPPPWLAGGGTTSVCGTDWAALVAAAPVPPLPVASVVTATKPATGVLGSPRTSRRPAPKEVACTTPAPSLRFPSSPTKALGSQAKTAHGSELGDAAAAGNNSGGAGKTRPPPRTPRVSFEGKKPKSGGSGNRSPRRKRRSDSGVSKLSPPSPSSKLSGASPVKRGVAWDETTGTYITHPNQRQRQGAAHSVAVAAGAATLTALPSAAPRGVGTSALEIPDKLHYYFARTASSTVASGDMAAAQAAKPTPFGPLCSSAMHFGRGEDATSALSAAAALLSAKAVKQKKCESEATRSKTPTGVSTWKKSIETKMAAAALAAPLMVVPAVRSPRLAENQRFRSGCVPAKYDLCGPSGETIMVQHQGPQYPPQLLAAAAAAPANVSPKTPPRTASAGKMVQLAAEKAPAVRFERYYSMMSSGGVEVVEVETAQSSAHASCPSAIRTPRSARFPAQQQPRGRVGDPVAAMYARGWAANPTYQACGAAAQVCAGPVPPAQCSVFERLTSNYYNVYSSATALQAVSPPPVAFSPRGDRSDRERHQLPHRRNLSAPVARTHRGRARCPATLQSVPKGFLSPRGMRKGEQERTAAPVSSVFARSNASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNE3</accession>
    <name>A0A088RNE3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_150140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697392.1">
        <property type="nucleotide sequence ID" value="XM_010699090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNE3"/>
    <dbReference type="GeneID" id="22573430"/>
    <dbReference type="KEGG" id="lpan:LPMP_150140"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150006400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_150140"/>
    <dbReference type="eggNOG" id="ENOG502S52E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051252">
        <property type="term" value="P:regulation of RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000003">
        <property type="entry name" value="Zinc finger CCCH domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN96739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="214" mass="24033" checksum="FF3054D8716C45A7" modified="2014-11-26" version="1">MPKANKHAEVKPSKYKTSLCRFFFRGEECPYAGRCAFAHGEHELQTESKNVELLKATGLQRLDGLHTQEIAVVESHTPSINSVTDSSPSESLVLSEPETPTSPVVRLRRRTVMVSLPKNNRRSEMYQSPYNATQYDPCYGEYSRVEYGYLTQPAPQPVYHVQTIESSHAGLYASSNTHDNQYCACRFSATCSQGQPSKYRHNPYGMTGRIAQCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNX1</accession>
    <name>A0A088RNX1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Conserved oligomeric Golgi complex subunit 6</fullName>
            <shortName evidence="9">COG complex subunit 6</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Component of oligomeric Golgi complex 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LPMP_200380</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for normal Golgi function.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the conserved oligomeric Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus membrane</location>
            <topology evidence="1 9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the COG6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698237.1">
        <property type="nucleotide sequence ID" value="XM_010699935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNX1"/>
    <dbReference type="GeneID" id="22574245"/>
    <dbReference type="KEGG" id="lpan:LPMP_200380"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200007600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_200380"/>
    <dbReference type="eggNOG" id="KOG3758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272987at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010490">
        <property type="entry name" value="COG6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048369">
        <property type="entry name" value="COG6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048368">
        <property type="entry name" value="COG6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506">
        <property type="entry name" value="COMPONENT OF OLIGOMERIC GOLGI COMPLEX 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20653">
        <property type="entry name" value="COG6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06419">
        <property type="entry name" value="COG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01087">
        <property type="entry name" value="COG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric complex COG6 N-terminal" evidence="12">
        <location>
            <begin position="177"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved Oligomeric Golgi complex subunit 6 C-terminal" evidence="13">
        <location>
            <begin position="324"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="425"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="501"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="570"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="215"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="442"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="507"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIN97530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1142" mass="121780" checksum="6EE01A50283C6A88" modified="2014-11-26" version="1">MSAPVIDANTAAPPPQPPSWGDSKVASLQSATVASSLALPEKQPAAPGVTVGLAPVAAATNSHVSPSLPTPPVLAQSQPPAAALRPTGVLLPSSSAPALSFSAPAKSNATQRKVAKLLDISTSSEIKDLASYVDSILPGYFYSLGDNDKQEPSSAEVVITTSHSSPSALSSTASSNSNNSNKAITSTALRSALDHRTINVHKSFLHEFTAVYQSYQRVAALVNELQSKCSSLENTLNTTTGDPSREVEDFFYQIQAYQAELQLVQTHDKDVDEFRKQHHFGAAEQQVLEDGPVDMTFLNVLERARQVHRRSSELMHSQEYHQGAVAVMEATYGAIARATEKIARHLLSTTASGDRSTATLAAGGVGSIAADMPEVTGFQLRCVRLLYEESPTLHEKLLDEVARMRRASVLRRYFHLLTTGSANTSTGLYQSGGQPSACDDGGESRYGSDEAGRGARPLEAELNNPTYFFSSLCAWLHQTIVEEQDFLQSFFVGDEREVGVGGRRSHSTTAALSSSPPQAGGDAARAAHDAARQQALLDSVFGGVCKHIRAALDNALERLGRTAAALGAATGDLESEGRADGRSSTARADSTGAVAPHKGPRGLTGGLTRLFMAATGRAPSGAFRGAGHDESNALLQRYAGVTTRAQQEAVASSMLRPLLEGIQICVTLVQLFEYYTATTFVPLLGGGSSLTRLIRKTAPEQARGLFQRLLHVLETHLLDSTVGIIGRTATLRRLASSNALTQATDCDDAAGTPPLAAEHRTATKGGSAAFVLDFLVAFTYGSDANVIGGVANLSESALLNDSESAISTPVSTLSVATSAIRFREANDGQLQRHSAHDLRRVLSQLILPPSPEVAEYCAVVHSVLQDTARQIELLGAITEQQRAAAAPGRSSSDQQSALDPGAAALATDTEVKWFVQELLQSLLKTVHSVGAEGPLRTNLDDACLAIVEYNVLHQLRNVLEQHATVLGVLFNGSDAQCQEAKQTLNSIQEECVTTMIALRQRLLSAWANAIKLFYFPVSTRTIVAAMSSLAAVEADEKRFAIIKKDVRRVLKQFINVYNTVASLGHLPEPVPLLQALAGGEDMCEEVRRKVTLNIVEDVYPAEFMMLSSFPPIEEVVEVQTEMAPQNLLKLVDFSSPALATAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNZ7</accession>
    <name>A0A088RNZ7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_161100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN96984.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697637.1">
        <property type="nucleotide sequence ID" value="XM_010699335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNZ7"/>
    <dbReference type="GeneID" id="22573688"/>
    <dbReference type="KEGG" id="lpan:LPMP_161100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160016300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_161100"/>
    <dbReference type="eggNOG" id="KOG0940">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3045089at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000119">
        <property type="entry name" value="WW_domain_containing_protein_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051105">
        <property type="entry name" value="WWC/KIBRA_Hippo_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14791">
        <property type="entry name" value="BOMB/KIRA PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14791:SF29">
        <property type="entry name" value="PROTEIN KIBRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN96984.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="611" mass="64984" checksum="D2767A7D161FCCDD" modified="2026-01-28" version="2">MHLLVDGDYLLSGFRPTSEEEVKAAVDRLMTAIEQQLLLPAGADTAVTTLVSRIIFFSSALIKGLEEGPRTCVISTLRRLRFQTHVLESIHGRAGTPVDAALCTKMLQLSLLPAGGGVSGSNSAVLSHGHAAHAFCLVTPNAYLSTAMELMASRECGEIVFAVYEGDEVAEELLGYASARYGAAGGVATMAKHDGVTFLPSTEAAVAALALVQQQEQGNLSVSALTELKSLQVRLQQRKSTTGAGATVVMPKATAATAVAPPPLPAVSNLLAPPSGPQTRVATAPPSSPASRRSSSASSRDDGDGAKHTLPQGPPPVLAMAKPLDQVNVPAPPSFFETGSLHTVTTATSPRTVVQHASPPSAMPPLSSTSPLSATNGVAGAATSIGEPMVSTTLPVEWGLVYDAAQQRHYYAHTNATGRTRSTWQHPLGPQKQLELEEQVQTWRAARLHSPHSTQLQPSSALPDGWEERTDPQTRRTFYVDHKSKTTSWERPQPTVANVSSHASGSGAMALPPPWEARVDPSTGRTFYVNHETKTTSWEPPAVARSTCGTESLSQHAFYANDKTRQTSWNAPRSAVPTLPAPWEAHVDPSTGRTFYVNHETKTTSWERPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RP04</accession>
    <name>A0A088RP04_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_201540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698355.1">
        <property type="nucleotide sequence ID" value="XM_010700053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RP04"/>
    <dbReference type="GeneID" id="22574363"/>
    <dbReference type="KEGG" id="lpan:LPMP_201540"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200020600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201540"/>
    <dbReference type="eggNOG" id="ENOG502QUF8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272249at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="529"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="742" mass="81533" checksum="9B914210DDC95BC8" modified="2014-11-26" version="1">MMPFGELCQRKGASFVARRAPQAGALRVICANSSPIQASWMPPCAAAVPRCACRCTSTLSRNSVLNAENTSRSPKSCWGTAPAQSSTSRSDDDPANLTTPIAELLQHREHMINMYVGLLADRRVQYRDQLLLNALSPIQAGMQTLLRHLLASHPEAVAGAMEVRQEARAQMTSDDVRRLKETWMQISGVAAHSGEAAMRHAYFRELRDCYATLLCSGLPRTDNEVRLILSEMHSTDLIEPDASFYEAVFIALWSLDDVREATGEHRAAGSAHTSEIVSGEVRQLRRGVAGDLAGHYMGHALAQLSTSSTANASAGLGHTAVRPETWEVFFTTLANAQPAPKLMDLWWKRFLEWLDEEATPVSAKASLGLQDEGASAAKGRPVPYQAAHAVLAWCAQSREMERALNYFNVVNQRGVTLHTTTMPHVSLPSELAEGFTRAGCLSSPSTRTPLQQLQLALLVKLMASTKSIKMDGGLRALVVRDVQRQVTPDVLYTAPWGVINDLISGLSVASAMQLLRQCSSFSATAAVSSTTTKKRNRSEDRAGDDEVAVGSAVKGSGRREIPFFVWASLLRRCCREHLQDEAESLFLFLRKQFPITVPEKRELIEIMMRMYTTMHPADFPSAMDVFLQHVLRTPEGEPKVEPDAVLYGLLIKSADSRNAAMMVFLEACAAGVALTEEVFEALMSSTQYKRLAWLSRKLPHDYAASSLDAQLKIPANADAHLRREEALRARGKPLYDSTGDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RP93</accession>
    <name>A0A088RP93_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_202620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698465.1">
        <property type="nucleotide sequence ID" value="XM_010700163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RP93"/>
    <dbReference type="GeneID" id="22574472"/>
    <dbReference type="KEGG" id="lpan:LPMP_202620"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200032000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_202620"/>
    <dbReference type="eggNOG" id="ENOG502SB6Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271204at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="89" mass="10364" checksum="184EBBDECEC3D9B9" modified="2014-11-26" version="1">MLCFTRCALMRRSQRALEQKFKSHCGSTNPATDTSVAGKVKAELKKMIKIQLVLIPICVVLMVWMYPTPTEEDERRMRLEYERNAGWKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPL7</accession>
    <name>A0A088RPL7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_205510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN98042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698749.1">
        <property type="nucleotide sequence ID" value="XM_010700447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPL7"/>
    <dbReference type="GeneID" id="22574763"/>
    <dbReference type="KEGG" id="lpan:LPMP_205510"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200062000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_205510"/>
    <dbReference type="eggNOG" id="ENOG502QVA0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="409136at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13905">
        <property type="entry name" value="Thioredoxin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like fold" evidence="2">
        <location>
            <begin position="259"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="389" mass="42133" checksum="787A1E55A1170E7C" modified="2014-11-26" version="1">MRNVGNGPGMAGSRVPASGSSAFRRSGGGVEATSRGASPIGASSVFYDGADNATHHAPYGPGALGGDWGDAAANPSLYSWKADPSRNRPPPNIQPSLSGLRGNGGSSLSQNAKRVETASRPIEKLDERGGAGGDFKSGATNTNWLGGPADGAIPDTLERATLQHAFGSGDFSMVDRQQLTLTRLIHLMLDATLKPRDPDSRGFGGDGATKLAEQREELKTMDQRIVPFQHDDVMNDYLKNIDRLHSPSGALCQRDVLKGRLVGLLFFTESERSLTFMRYLQVFHRRHSPDFVVVAVSLAAKEMMDITRSFGFFHCTHRDGASWVSRDAGLVLRPFVALPRLIVVNGTSGIEVTRGGVTAVMANPETCFQAWRRGEGGFRYRDWFKSMYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPP3</accession>
    <name>A0A088RPP3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LPMP_171410</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697832.1">
        <property type="nucleotide sequence ID" value="XM_010699530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPP3"/>
    <dbReference type="GeneID" id="22573884"/>
    <dbReference type="KEGG" id="lpan:LPMP_171410"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170020600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_171410"/>
    <dbReference type="eggNOG" id="KOG2301">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272031at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF7">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="3" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839027" description="Ion transport domain-containing protein" evidence="14">
        <location>
            <begin position="21"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="438"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="15">
        <location>
            <begin position="241"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AIN97179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="665" mass="72660" checksum="F1D8CA0D337181F4" modified="2014-11-26" version="1">MSHPVQISWFLLVCLSTAIALTLQPCHDTSSDAYATLYALQVACLALFWRRMVAEVVAGGLFRCSDAAVNNWRLPSGDYNATVMGYTGSTSALRKETWWQAASRYDAFWAGTLVGVCHDDGEPLERLHERCDGDRQYNNVLEPPWLLRHPFHCRPTAYPLPRCPYNRGSTGVGASSHHDRVSDYGTLHTTADPVCSLAQVNRLHDAATVFPSTVTRCCKSTMPPHPLGPTGPLAHPLLQFFFVQTMLVITHGYLASTHAGDSLWQKGMILVVDCVAEALSGAEVMLGVVAYGVRYLTRAPYMADVILFAFMVVSVASPLLRFTGVVVFVTLMKGVSTGLALLPAIHHMRMLLSSGAIALLILFTYAVVDTLLLGDIATDGVYLSEKRDFSTVIGPLLMLVDCGTFDQWHLVLHACYDGAACHGNASAPCGHTYSAVTFFVSFIVIASLIVGHLHFATIVATFSVPLLIDVIQFFIEARRVWQMGVGADLCACHFDTVLTVLPRFSTRHTDGITSETASKPGVIAFLSSLRLPLDENLGVRYDDVLRGFAYRKYNMNLAESSANPCARDRLTCLTVGEHYGQLLLQRYRDDVSRLAYFKVGGLHLSFTGMSAASPPHDSDGEHNVFRRREDGLLVLKGALPIPSSNAFLYTFPGESNDGGILPPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQ07</accession>
    <name>A0A088RQ07_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">La RNA binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_210570</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698844.1">
        <property type="nucleotide sequence ID" value="XM_010700542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQ07"/>
    <dbReference type="GeneID" id="22574879"/>
    <dbReference type="KEGG" id="lpan:LPMP_210570"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210010400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_210570"/>
    <dbReference type="eggNOG" id="KOG4213">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="439993at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07323">
        <property type="entry name" value="LAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12291">
        <property type="entry name" value="RRM1_La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000158">
        <property type="entry name" value="La ribonucleoprotein domain family member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000902">
        <property type="entry name" value="La RNA binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002344">
        <property type="entry name" value="Lupus_La"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF157">
        <property type="entry name" value="LA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00302">
        <property type="entry name" value="LUPUSLA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="7">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="94"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="187"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="307"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN98137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="333" mass="36470" checksum="D96C30F03FB86D37" modified="2014-11-26" version="1">MSELAAKICRQVEFYFSDVNVAKDVFLKSKMAEDPEGFISLEVLLTFNRLNSLTKDPKVVAEALAGSDKLVMHTNGLSVRRKDSLPESIQTDEQTVYVKPLPALATLEQLQEFFSAHGTVLAVWRRYFQGGNKDAPAESRTKPSVFVVFASKADAEKFVAAPPQYDGVQLSAQMKVAYLEGKAAQVASQKNRKREREDGVDAGAPSSAAPRTPAMPTNSSYRISGCGAIEKFSEVKGLWPAEEQKGVRYVYMPTKEEALIIFQDAETAEKMIVSVKTRAATLQGKQPEVMKLTEEDEKALIANVEKEISERAAQHGSRGGRGGRGGRRGGGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQ70</accession>
    <name>A0A088RQ70_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribosomal biogenesis protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_211380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698924.1">
        <property type="nucleotide sequence ID" value="XM_010700622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQ70"/>
    <dbReference type="GeneID" id="22574960"/>
    <dbReference type="KEGG" id="lpan:LPMP_211380"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210018400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_211380"/>
    <dbReference type="eggNOG" id="ENOG502RAQX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275261at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="262" mass="29001" checksum="B2F999F25F459C83" modified="2014-11-26" version="1">MPQDKRLIVTKAVLYKLQRVCAEEGSRSSGGADQEGIYLEFILPFVITTQCPQLVRGHRFHLPHRVYAANGRTTCLIVPKVISHDCGKINKRHGYYDAVVTAEAICKRGDAEAMKRALRVAATFSHFVVDSRIEAKLPNAITESVKASVSSAAATFSSAPNSAVRCPHKMITPLDGLDERETLSFRLSQGSTAGLVEWHKQGQLLFRVGHGGMTAGAVCENAKAFVVSLKKEFPTVWKYIQEFSLVSNRTERIRFMEVHIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQE4</accession>
    <name>A0A088RQE4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Regulator of microtubule dynamics protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Protein FAM82B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_191280</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698122.1">
        <property type="nucleotide sequence ID" value="XM_010699820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQE4"/>
    <dbReference type="GeneID" id="22574182"/>
    <dbReference type="KEGG" id="lpan:LPMP_191280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190019900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_191280"/>
    <dbReference type="eggNOG" id="ENOG502QSJV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="69711at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097431">
        <property type="term" value="C:mitotic spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001413">
        <property type="entry name" value="Tetratricopeptide repeat, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049039">
        <property type="entry name" value="RMD1-3_a_helical_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056:SF16">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21033">
        <property type="entry name" value="RMD1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN97469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="228" mass="25935" checksum="A89EBBD23EA161E0" modified="2014-11-26" version="1">MSDWEAVSRESEEVLAKPDIKGCHEILVKTYEGGNHHPEILWRLGRSYYEMANESTDPAVQEPYLKEGMELCKKSVEADPNNFASHKWLGILISEQKVGSKEKIANAYVIRDHFLKAVELNPNDATSLHCMGNWCFKILQVGWLERKAAALILGEPPSSTYEECLGYLLRSAEAGNTIYNSTMIGDAYAQQRMYDEARKWYQTAIDMPTCTELQKRNHEAAIAKMKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQF1</accession>
    <name>A0A088RQF1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_220480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699049.1">
        <property type="nucleotide sequence ID" value="XM_010700747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQF1"/>
    <dbReference type="GeneID" id="22575094"/>
    <dbReference type="KEGG" id="lpan:LPMP_220480"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220009800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_220480"/>
    <dbReference type="eggNOG" id="ENOG502S0C4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266335at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051037">
        <property type="entry name" value="RNAPII_TF_IWS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010:SF1">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="506" mass="54868" checksum="CEEA2B7BAC3252C4" modified="2014-11-26" version="1">MEEEDSILGLAPAPLPFHTDGEESVSANGYMIDVSSSQVAAGAGAEGGSSWSFEHALRAASAAAEKGDGNDADAGRSGGTDDDEDGSSDAVVNGEKRAGDVMDFRDGGTSSGAEGHMDDASLLSITDKKAAKRLGKRLYKQWKKLQKASKLKKDRHKSSKKKGSKKESKHKEKVAKDNKARGSRSSKRKGTKARGDEDNDAGNMFLNMADGTGEVNDEFGLVPADDLSDAAAAIEARLHKASLRESKMRAEKAIKKAAQRKTSSAEIVSIAKELVGAMAKARQLDDDIVSGRSTRPGAFPLNRVALKNTVQARCRQKYMVGPLVEAGILQELSYWLYDVDRADPAPYELRTTALDILVSLPMEGSIPMTEDLTAFMGVSREHLIKTDLGRALNALRRYNDETIDNKGKCVELLTSFSRVISGTSDKDQTDERKSKAVWKCQRDPTVASPFEVLETCSEAFQRSFMKPDPRDPTSYNGVLPWRPPVATITNVSGKLSDYIEKTTIDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RR50</accession>
    <name>A0A088RR50_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CYP11</name>
        <name evidence="7" type="ORF">LPMP_230060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699165.1">
        <property type="nucleotide sequence ID" value="XM_010700863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RR50"/>
    <dbReference type="GeneID" id="22575210"/>
    <dbReference type="KEGG" id="lpan:LPMP_230060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230005400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_230060"/>
    <dbReference type="eggNOG" id="KOG0865">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097014">
        <property type="term" value="C:ciliary plasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000002">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="26"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="200"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN98458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="296" mass="32077" checksum="2EC2B799F04F13AA" modified="2014-11-26" version="1">MSRMSVPPKVGKRPDIAMENTNPKVFFDINIDNKPAGRIVMELYADTVPKTAENFRALCTGEKGKGRSGKPLHYKNSVFHRVIPNFMIQGGDFTRGNGTGGESIYGTTFRDESFSGKAGRHTGLGCLSMANAGSNTNGSQFFICTAATPWLDGKHVVFGRVINGLDVVKKVERLGSSSGKTRSRIVVSDCGELAGDKTKAQLQQHQQQKQQPAKASVGMRPVTDTKAVEKKLVVSSPVAEAKKTLCAKKDALPRASASSEAKKRIREVNEDEARLVRLREKKAKLAALRSSAEGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RR81</accession>
    <name>A0A088RR81_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SAM-dependent methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_231630</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ANT/ATPSC lysine N-methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699319.1">
        <property type="nucleotide sequence ID" value="XM_010701017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RR81"/>
    <dbReference type="GeneID" id="22575368"/>
    <dbReference type="KEGG" id="lpan:LPMP_231630"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230024300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_231630"/>
    <dbReference type="eggNOG" id="ENOG502S6X5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272302at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905706">
        <property type="term" value="P:regulation of mitochondrial ATP synthesis coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026170">
        <property type="entry name" value="FAM173A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13610">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13610:SF11">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN98612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="239" mass="26151" checksum="ECEA9D69EF9772B1" modified="2014-11-26" version="1">MADLPFQWDDGNFISPFEAASEADMEAFAEWLTACYLSSIVHNSSTSSRNRADQLCAVPWPYEMRLTDLGCGDATAVLSLAQHLRKNWCDLQSTTDDAPPPDHAVPLHIIVTGIDLDDALLDTAAANASVFSVTVASPSSLPVSIETHILSQDLRTIDVDVHFPRCVQGGADSFYPSTRPPYVLYMYLLPDALALLREKLVDILERGWVVASNRWPIPGLEASLQACAGHVHIYSRTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRB8</accession>
    <name>A0A088RRB8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BING4 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_230780</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699235.1">
        <property type="nucleotide sequence ID" value="XM_010700933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRB8"/>
    <dbReference type="GeneID" id="22575282"/>
    <dbReference type="KEGG" id="lpan:LPMP_230780"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_110008500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_230780"/>
    <dbReference type="eggNOG" id="KOG1272">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251154at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001925">
        <property type="entry name" value="WD domain, G-beta repeat/BING4CT (NUC141) domain containing protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012952">
        <property type="entry name" value="BING4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040315">
        <property type="entry name" value="WDR46/Utp7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085">
        <property type="entry name" value="WD-REPEAT PROTEIN BING4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08149">
        <property type="entry name" value="BING4CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01033">
        <property type="entry name" value="BING4CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="300"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="BING4 C-terminal" evidence="7">
        <location>
            <begin position="382"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="527"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="595"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="527"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="601"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="623"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="645"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="668"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN98528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="680" mass="76726" checksum="A2955EC4E8C8667A" modified="2014-11-26" version="1">MPPTSSSTPRSSPPVATTAPRRGGAQEKSSKEIQELIDKRMEELKEETVQHEKKFIQGRWVTDTAALRNRGARQREALNRQAPKRLAKVNMYYYMEEANTGLLLDDHEVADRISQRDIVSGVDLQTQQKRYSLVLDKLGPYKIDFSMNGTHLLLAGLRGHMASINWKSFQLESETQLKDRISDAVFLVDHSMTAVAQKKFVYMYTKDGTEMHLLSKMAHMDRLGYLPKHMLLAATSSIYSTMQYLDISTGQEVGTKVPAVMRDPTSTLAVNPSNGVTATCDLRGIVKFWSPAVVDPLLQLKGHKGVIEDICFHPNGRFFLTLGGDHKMKVWDCRTLRTLEEYAVTYSFHTLNISSSGLVALGGGTHVHIWKDMFTAAKPSSPYMKFGLGYGNIAEQVKFCPFEDVIGIGHSRGFTSLLIPGSGEANPDFYYANPHETERHRKERVVANLLDKLPPDTISMDIQVPGVDEKRLAEYNENLRLNRKARAIREKKMRRAGKSLGETAPTGLLVGRDEEVDEELGYKEAPKTREVKSKQELQRERKMAKWDKKDSADKVRSKQTLRASRIAQRNRMQMARDARNGVYDEDALDAEEAEALAAKSRAAKQHRKRARQEVLDMASDIRGQLREDFDYDVEARPAAHRRRQQSHDDSGTNGHSARERGSSEPEAGARANAALRRFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RS38</accession>
    <name>A0A088RS38_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">U2A'/phosphoprotein 32 family A C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_240460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699387.1">
        <property type="nucleotide sequence ID" value="XM_010701085.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22575455"/>
    <dbReference type="KEGG" id="lpan:LPMP_240460"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240010500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_240460"/>
    <dbReference type="eggNOG" id="KOG0531">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1517790at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050836">
        <property type="entry name" value="SDS22/Internalin_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003603">
        <property type="entry name" value="U2A'_phosphoprotein32A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652:SF3">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00446">
        <property type="entry name" value="LRRcap"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="U2A'/phosphoprotein 32 family A C-terminal" evidence="4">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="U2A'/phosphoprotein 32 family A C-terminal" evidence="4">
        <location>
            <begin position="1364"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="domain" description="U2A'/phosphoprotein 32 family A C-terminal" evidence="4">
        <location>
            <begin position="1641"/>
            <end position="1659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="871"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="880"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN98680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1774" mass="191830" checksum="84ED4444EC324C9D" modified="2014-11-26" version="1">MSARATTCTCVASDINVTSASLTTAAGVAAAPSAQPSTSPAQIEQLRQKLSSSLHCQPELRDLLGLCAESNAWTAEEATQRPDMITTIELFLLQVPRIPLVQFFPNLVTVKLMSIGLESMASLASLAHVEELWLSDNNICVIEGLDTMTRLRRLYLQGNRIGSLNGLPPLRHLRELWLSRNRLSALTHLTSLRKLRSLYVSANPLESLENAFSKDMSHLHEVNLSGCHLSSITEVRHLQQLSCLRSLWLLDPLFGDNPICHLNNYATLIISMLGSLDSLDGVVVTSAQRSAVESVLRKKQLYYAMRAQMLDTQITLLARHAETFALCHIQDSRNALRKLKSCVQPLEHERAERAIYHLEEKLGTGSSRGSLCRVTADEGKSGDDSAEAPLDVPMATLEALARQLSRAVDTREVQERMTMLRLSEATHAAKAQAQLLKERFAVELHTAGNVRLENLSPDHEVYVAAVEMMQERFDSALFNERFGIAGVEVTCVRRIVNRGLRVRFDERVKELRVDLSNPQLRSRFVGLFGIVPVTQQGQSACLQHVLLNGTTARLAAPRGDGKKSSAVSQADSTLCQHVPAEEGIPLTNSLFYADEERLLSCGAAARGMSRDCDAAPLVSHQSFGAATLPSESEASPPFGGQVVVYRVYLGKTVHALGGGAGSAISPPASFLQQNGRVWCKDYSADTCAAYRLLPSAAAATAPAGESGSASAQPLPSSYMWYCFDRALLLPDCVVDYTYSLQATHPSQPQRSPTPTVGGALGMSQAAALALLNGLPPSAAVGYVASSADADDRQRSGKQTDIIEDVLRCAEPLLKFIHWCGSPSKQARCRGTASHKNTLQYVAELETNDALASVHKALGKTRMARLLQNSARDDSAGGGEAQSSDANSTSAANPLQARHVEEYAAQMGVSGTPLMLCVLRSRGITAILQNFAAPLCSSITALDLAYNRIASVSWVALAKEAPQLQRLNLSGNILSRLHLDGSSLPSLRVLDVSDNKLVDVTDFSSIRTAAEALEELLVHGNPFLQHADGQEAEARLWLYLLPPSTSIMAMAAGGSPAIVKLNAQSLGTYPGTLAAQRFRRASLLPGGLPTSYMSCVTACLVKSVQRDEELSCASTGVFSVDYNTTYESSFEQAAAQLEQLTAAGELEAHLRVECALHAALDEARPRLTNTTIDDRNLPLSPSLLSCLNECHTFRWSRGLLDDPSGLVDLLPNLCCLTLRGQALTDVHPLLHLRGLESLNLAENHITQLPCLAELKALRELVLDFNELTALPLALGPLPTLRMLSASGNKIVHVDVNLFLKCTTCAGSHDTTSLPAATPQLVALHLMYNGIADMNVIYALRDVPSLLILNVTGNPCTVPHGATNDDNEVRPYLIHAFPQLKMLDGIPISPAEVAKSREVYAGKINSDLLIERARGPPETWASVRSLNLSHSSLKEVNLLERFVSLEVLHLQHNLLVSVLGVEMLRELTALDLSHNRLGSAPWRGSTGGALSTNGVAATSPAALGDTLAHLKLLQSLSLEANQLTDLSTLKLRFPHLKFLNVRSNELQHIQRGLEHLPELRELLLDQNKLRGLSTDAFAANKKLVILSAENNTLRSVEGLQRCGSLEQLRLGANRLGELNALLHDLEACPLKAAVFVGNPIARKTNYRAMVIMRFAQLTDLDRRVVTPEERDKAASARVTELVAPPNVVIDMNYFAGMGAASAGLPGLPSQSGLKVNGGAAFSSRGRGAVPLPNGAAVNRSPSQPQLVGMRAVFVPNKQGGATDRLVVNQRIRPYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RS50</accession>
    <name>A0A088RS50_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_240610</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-13 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699402.1">
        <property type="nucleotide sequence ID" value="XM_010701100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RS50"/>
    <dbReference type="GeneID" id="22575470"/>
    <dbReference type="KEGG" id="lpan:LPMP_240610"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240011900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240012000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_240610"/>
    <dbReference type="eggNOG" id="KOG0246">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007019">
        <property type="term" value="P:microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01367">
        <property type="entry name" value="KISc_KIF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000012">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971:SF4">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971">
        <property type="entry name" value="KINESIN-RELATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 6 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="4"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="326"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="443"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="361"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="445"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="459"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="88"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN98695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="578" mass="63337" checksum="B3B4A3EB45C434A8" modified="2014-11-26" version="1">MSSRICVAVRKRPIPDPEMDIVETPTPRCIVNEPKIKYDLSHYTDRHTFTFDEVFGESCNNAGVYQRCCLPLIDTVFNHGNATCFAYGQTGSGKTYTMLGSQKEPGLYAIAAREIFARANSINAVVYVSFYEIYGRKIFDLLHNRQRLFAREDADKVINICGLSEHQVTDIQEIFDVITAGSAYRAAGQTSANAESSRSHAVLQVEVRDTRGGNARRAPKTIGRISFIDLAGNERGADTFDCDRKTRMEGAEINKSLLALKECIRALGMGKSHVPFRGSILTEVLRDSFTGNSRTTMIATISPSSQHCVNTLNTLRYTQRVKDLGGGAGGGAKIEQVASSPPGRRPAAPRRKPFEALPVKNRPEWVTDFASDRSPDVSPSENAGGGGGENDGVAAAAAPRNVSKPRGRRPSVGRSGGTPPPVSAMVKVKDPKIATIVQNHIAALESEDDDDDGDDYCGDDPRAAEDGGVMQREEERQVRKVHAYVVEEIAKAEDKLIALHRRHIDSKMTGIKEEITAIQSFEESDSVDEYVARVRGLLLKQRDDMNEILVMLNGIGSMLRDEEDLSKTLTSSIGMRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSA6</accession>
    <name>A0A088RSA6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cobalamin adenosyltransferase, putative</fullName>
            <ecNumber evidence="7">2.5.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_242210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the Cob(I)alamin adenosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.17" evidence="7"/>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699560.1">
        <property type="nucleotide sequence ID" value="XM_010701258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSA6"/>
    <dbReference type="GeneID" id="22575630"/>
    <dbReference type="KEGG" id="lpan:LPMP_242210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240029400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_242210"/>
    <dbReference type="eggNOG" id="ENOG502QS64">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="549173at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:corrinoid adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1200.10:FF:000004">
        <property type="entry name" value="Cobalamin adenosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1200.10">
        <property type="entry name" value="Cobalamin adenosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016030">
        <property type="entry name" value="CblAdoTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036451">
        <property type="entry name" value="CblAdoTrfase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040807">
        <property type="entry name" value="DUF5522"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029499">
        <property type="entry name" value="PduO-typ"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00636">
        <property type="entry name" value="PduO_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12213">
        <property type="entry name" value="CORRINOID ADENOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12213:SF0">
        <property type="entry name" value="CORRINOID ADENOSYLTRANSFERASE MMAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01923">
        <property type="entry name" value="Cob_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17653">
        <property type="entry name" value="DUF5522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89028">
        <property type="entry name" value="Cobalamin adenosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Cobalamin adenosyltransferase-like" evidence="6">
        <location>
            <begin position="178"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN98853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="376" mass="40992" checksum="CBEB2F733CF52467" modified="2014-11-26" version="1">MWRAVTCDTPRATAIVFAVMALSALVYTTVRRGGPRVTHGRFFSGCTCASPMATIDPVVAEENPIERRLTLEIKALHAQAMANGEDTYIDPCTGFTVLTRLGLMRNMKCCGNRCRHCPFGHVNVQSKRLMTTKAEGPFAATSASSAATSAEASSAARTAAAKDGKAASGGNVPKRSMVYTKTGDNGTSALFTGERRKKADAVFEALGAIDELSSHVGLASAMLRSAAERREHDEAMMSMLEGIQQELLNAGTVVATPTAKNPEDEATKHMITILEGYRFLDKTEEIARNIDIIDSRLTPLRVFILPGGGNVASAQLHVCRTTCRRAERRMVKVRDLYGETYTDHLRQATVYVNRLSDFFFVAARSIAEEDIVRKYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSB1</accession>
    <name>A0A088RSB1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cullin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_242260</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699565.1">
        <property type="nucleotide sequence ID" value="XM_010701263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSB1"/>
    <dbReference type="GeneID" id="22575635"/>
    <dbReference type="KEGG" id="lpan:LPMP_242260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240029900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_242260"/>
    <dbReference type="eggNOG" id="KOG2166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000065">
        <property type="entry name" value="Cullin-like protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000066">
        <property type="entry name" value="Cullin-like protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cullin family profile" evidence="6">
        <location>
            <begin position="395"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN98858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="743" mass="85262" checksum="0FA8649AA3B2E9BD" modified="2014-11-26" version="1">MLEEDRQALRKMKADFEALADLANSDFKGYNTFERRMNHYNTVYTAATRNTSRAAEYPGYDAGELLYMEYNEMLTTYLWRYRDLSGDSEKGLFQKILDVWDHYKILMKWNMRTFGYLSRYYIVYHSKPSLQQVGLSIFLEQVFKKNADVVSSITQKLLLKERADRVVSTDAKQIATAIGLFSSMNIEDTQSIYITAFLEPYLDKTKRDYERFLQEWDAAADAAVFLRSVHEALTNERSICRRYFSMQDEERIMTCVEATLVDSPVTRNKLVDSPTGVLAMLRNRDEAQLQMCNSFFSRRESGVALLAGLIKKQIEAEGLELCERFKDEEASVDVVAYTTGMMHLQEVYPQLLSRCFQLDFTLSKAVREGLEACYNHGVSVTSSSGGESHVVPFCEWLSHYVNHLFQQEAGPASAEVDRIVATLAYVTERDRFIATSREHMADRILFPVKKFSEANERALIQRFRQRCGPACTACLESMLHDWEASSSFRVMEVLASKNIISPFEVNLLVAKKGIWPSRLSDEPDIVVPSFLQRVLEPLRDDYLAGKSGRVLTWSHECSSGELQGYFKKGTQLFYACGIQTLILLCFNSSPVCTPQQIGDRCHVTFASLQRYLSPLIRSRVLTRKSGKALLQLDDELTVNDEFVCRARRMRLPPSLARVSVVGSDRISKQVEEDRKPAIDGALVRIMKGRRSLEHAELILECQQHLSSRFSPDIKLIKQRIEELIRREYISRDSRNKGVYHYIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSB2</accession>
    <name>A0A088RSB2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_241420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699482.1">
        <property type="nucleotide sequence ID" value="XM_010701180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSB2"/>
    <dbReference type="GeneID" id="22575551"/>
    <dbReference type="KEGG" id="lpan:LPMP_241420"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240020100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_241420"/>
    <dbReference type="eggNOG" id="KOG0198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06606">
        <property type="entry name" value="STKc_MAPKKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000867">
        <property type="entry name" value="Protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF56">
        <property type="entry name" value="MAPKK KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="264"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="160"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN98775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="543" mass="58105" checksum="EC894DDD8ECB6CE3" modified="2014-11-26" version="1">MPPLTSVAKGSVSGPPSDGTKGTLRPFDVEQLSKRKRKSSGGSVLPPSLTEASSSLLEFRDPSEVTSITTPKQRTSHTSAVGGTLSSAVGASLSLSDQEQQQQQRRRASSIYAKDSALPKQPSASIADPGPFDQNLASSFEKDAVTGDATDNGADQSCVPIPPPEQRPPSTSPLPMALAREDGSRVAVADGSDFAGTSAEVIPVASPAAAQAPTSDRGDTEEVIASLRPSAEEEAQYTAWGTLSPDDLTPEMLQTRNASELRQWHRGTLIGRGTYGSVYLGLLPDGSFHAVKCVALGNKKAAADHLGVLELVSLSREINMMHRLRHRNLCTFKGVYYDPESASICMFMEYVGGGSLSALVKKFKPLPPSVVRSWTQQLLSGLHYLHSQHIIHRDIKGDNVLVDTTADPATLSQIKLVDFGAARRLTDAVSQSSTVIGTPYWMAPEVVDASGDGSGYSYQADVWSVGCTVAEMLTGRPPWPCRPSAPSAIMMIASATGMPTEIPEEEATPGCLDFMRQCFIRDPEKRPTVQQLLQHPWIQVKVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSH1</accession>
    <name>A0A088RSH1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_252140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699784.1">
        <property type="nucleotide sequence ID" value="XM_010701482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSH1"/>
    <dbReference type="SMR" id="A0A088RSH1"/>
    <dbReference type="GeneID" id="22575862"/>
    <dbReference type="KEGG" id="lpan:LPMP_252140"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250023600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_252140"/>
    <dbReference type="eggNOG" id="KOG1379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="60843at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000152">
        <property type="entry name" value="Protein phosphatase 2C, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF37">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="75"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN99077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="370" mass="40682" checksum="F3BFAD77AB407EAF" modified="2014-11-26" version="1">MGALHSTPLLPNGQPSAQALACTSADDVTSWGTPPDEAPEDEKDPTELVLQSWAFCKAKPTPQKMYRSDVDERKRRQSVSWRKRTSFIELDCGEDSFFVANNYKVIGVADGVGGWRSEGVDPSLFANALMENAKLFAETHRGECDPEKILDAAYTKVVKDGVVKVGSSTACVATLRKEDDGSHTLDVANLGDSGVMVVRNRDLHFRVHEKVHGFNAPFQLAVLPRSMVGRAFSDRVQDCVRESVQVQEGDVIVMGTDGLFDNRFNSELAADAGWIGKVEESPIAKIPLVGFLLSGILADEKIEYIDPYRVAQRIITDAYKTSVNPETNSPWASMLRQFGQTDAKGGKPDDITVLLSRVSTREELNNNTSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSU2</accession>
    <name>A0A088RSU2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Knr4/Smi1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_251170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699687.1">
        <property type="nucleotide sequence ID" value="XM_010701385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSU2"/>
    <dbReference type="GeneID" id="22575765"/>
    <dbReference type="KEGG" id="lpan:LPMP_251170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000019500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_251170"/>
    <dbReference type="eggNOG" id="ENOG502SJ0H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273589at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="344"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="572" mass="59217" checksum="26C6FC52095CAFDD" modified="2014-11-26" version="1">MPKCPRTAEVSRRLVDAYVTTLRQHLPTYCIRQLDKLPSAQEHQLTRLRQFYPGTPAELLYLLQRVNGTCWETLQALSGSAPSSAAVVQSLSTSASATAAVTAVKSKNMTSTGSTATTNVSPFSPAAALTRTTAPTTAGSAEAGASPTAPSRKMAAPVSTAAGAAAKTAKATTAAAMASEAAAFIKSKIAKKVSTMAGPRPRRPLPHFVALPILGSTYTSCPYYLKSVEQMLASEQQFPPPTATLPDEGEGWPPSQAAAAAQPSSPSFSMRKSSLRAATAPTGGESSDAPGMPVQCSGEVGAAGTVSDSPQSAASGATLNTHSIASVYAGCMIVYGAPPPPPTLSSSLSTGSASNTAASYGGTTGDTRAIFATTPTPSSEVPCVVYVDPRIDIHASFRQWLAFADSVQPHVRGSAPKIPDADPAKVAVAAATKNAADSSRLSPAPTPSQACTPPPPPPMKQFAASRLYIDFKPVELHGGVYGQVIQFVHGNPDSFSVVASDFGEYLKYIMTEEYGFTEELEDDDDNDDEDGGGEGGRSEPPLTGPTPLIITTTDGRPLTPPTPSRADSQQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSW2</accession>
    <name>A0A088RSW2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_260780</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699899.1">
        <property type="nucleotide sequence ID" value="XM_010701597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSW2"/>
    <dbReference type="GeneID" id="22575981"/>
    <dbReference type="KEGG" id="lpan:LPMP_260780"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260012600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_260780"/>
    <dbReference type="eggNOG" id="KOG1651">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="261803at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF129">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="296"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="341"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN99192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="356" mass="38116" checksum="0263640C9F6EB40A" modified="2014-11-26" version="1">MKVGDNTLTSVGEQSVPMLAQMLSPTTSVSRSHPVAQTQSAYETLACTHGVAVNAPDPNATKTIYDFQVLNCRHELYDLCQHKGSVVLICNVASKCKYYTESGYTTLVNLYRKHYCEGFVVLAFPSNEFGNGEPGDEDEISESISCMYPHIGKVDFPIMAKVVMNGDHELPLVGFLKSRIRGALGQSAVRWNFTCFLVDQKGAPYARFAPGASIAEIDVRIEELLHPVPPPAPMPLLQAADPSAAVEAAVAEGSHRASGAVDMSSLDENATYMTPPSPGLRNPEFVTVSTTFTVTSLTAQGGPPVSEDSDEANRDPSPNQVSVSMLDATVATVEDEDLTGTSAPPEETAAESEQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTH1</accession>
    <name>A0A088RTH1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_261810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700000.1">
        <property type="nucleotide sequence ID" value="XM_010701698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTH1"/>
    <dbReference type="GeneID" id="22576084"/>
    <dbReference type="KEGG" id="lpan:LPMP_261810"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260022600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_261810"/>
    <dbReference type="eggNOG" id="ENOG502SJ6Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273604at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="982" mass="103365" checksum="35C6D7445BE4E00F" modified="2014-11-26" version="1">MDGWFEYALGLSELIYSMKLQEYEDACASLLLTAATTTAATLVAEAGEANKARRSNEKFHHHRSGVEAAVAPTAARAAHVQSPVPMGSSAGSPLVSVDGTVLNAFTPSFAAAVSISSDVPAVTPDNRAVTDPGTESSATSVLNAACLAETCGIDQSTTSLSSLSPIHVPPPTVGWDRRAPNPTSGAVGSPAEIIEALVDAMLLRKSMRTATSRSQQIDDIQAEADFVFQELEDVFALQPGDAAAAAAACTGADVVRQPSPTLSSYTTTHFQFPGNEEECDVASEKPRALPSPLPASGAGERHLLYGELTSVGVRQLQAISMASTCVMREEHRRSPDYGTGDADFPAHPSTSMASSLGSFSTPAFNSAPPVPRSVSAPSLHTRHHCHSHSHASRGAVVVAADVGCGNGRLLFEWSRLAAAACRRRHTSSPRQHVDEVGTFVGAAPASFTRNSTTSTLGSTTEATTAAATKHRSNLLAAVYAPLGIENPAAVWRGWLGVGIELVPSRMRIARKALVPHYLNLKQALPIPSAGDGVAAPVTHLEPCPPEAIADADPSASYGASTSLQLGIVSHTTVVRSSIGSPASTGISVAKLPSCRAPQPSARVLLYEGDALAPGVLSNATMCQFPNFGCHSEPLLLRRSCVEHGGSGEHGCCAGGSTIPCTTTSTNTISATAAEMNKAHFLNNTRSGVHRRRGARKPASMELASITDASDDCIARGSTVKQGYYPLCHIEGEPPLTGREDPHLVVFCCGLGFDEAQVRRLCQRLEDMLLNPSSTAPVTTPSSVGEDSMMDPQPGMKVTGFPSYRTCQHHRHMAHGGDAEAAASLANCASSSLPSPEERSEEDMKTQYGMRPLTLTPADPGIDTATGIGAGFASHRRWESLTCVLLLRPMDVLLPTFPLFRYARRVFDTLHQPISAEDTALLLSTGSRAGGSPVPFSMRATPVSECLPGSSNVCDMVESDLWSTTLETTWMSAAPAWVVRFHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTJ9</accession>
    <name>A0A088RTJ9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_271000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700189.1">
        <property type="nucleotide sequence ID" value="XM_010701887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTJ9"/>
    <dbReference type="GeneID" id="22576278"/>
    <dbReference type="KEGG" id="lpan:LPMP_271000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270017200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_271000"/>
    <dbReference type="eggNOG" id="ENOG502S249">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276565at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="207" mass="23286" checksum="7F2D7CCD66A8C926" modified="2014-11-26" version="1">MFSQAKQDSLFSLSRGPSGIVANDKTRNKPLTQAEKYEQALVTAKVFLGDSHARMAKSMDKYNAVLNSNYWFYGYFGGNMVATMAACLALGNRWSFFRAYSGWISVFGGYFGGKACLGAHSSVLLGGVVTQLNHEIEEAKRMDEQTDHIVPDYLREADRLTQVKYELMPTLPEAVEARAHHTERTLDDRANALIEAYMKRKEALERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTU8</accession>
    <name>A0A088RTU8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_262270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700047.1">
        <property type="nucleotide sequence ID" value="XM_010701745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTU8"/>
    <dbReference type="GeneID" id="22576130"/>
    <dbReference type="KEGG" id="lpan:LPMP_262270"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260027500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_262270"/>
    <dbReference type="eggNOG" id="ENOG502S76R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271302at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38827:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38827">
        <property type="entry name" value="T. BRUCEI SPP.-SPECIFIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="115" mass="12272" checksum="F9F5612D11E7219D" modified="2014-11-26" version="1">MLGRRVFGSTAIPRFMYTRLHISSPAQAARMLPVLVPLTPSLSQSVGGMMSAVAQGSLESMPTLEVGEQDPASLKALLESISPLQLGFSRLFELWGIVRGTVMVSTILRGSVATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RU40</accession>
    <name>A0A088RU40_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amastin-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_270530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700142.1">
        <property type="nucleotide sequence ID" value="XM_010701840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RU40"/>
    <dbReference type="GeneID" id="22576229"/>
    <dbReference type="KEGG" id="lpan:LPMP_270530"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270012100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_270530"/>
    <dbReference type="eggNOG" id="ENOG502SF22">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273009at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009944">
        <property type="entry name" value="Amastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40741:SF2">
        <property type="entry name" value="AMASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40741">
        <property type="entry name" value="AMASTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07344">
        <property type="entry name" value="Amastin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="208" mass="22442" checksum="23A69539BE3CD87E" modified="2014-11-26" version="1">MCYTLSRIAVLLCAVIALAFAVLGVYLPLFEMPSRIAHAIQSLNASIQRTDFNISMEKATLERFGQLVSGAPAKSKMTLWRLSYGTSRANTSINLRGDYFTCYQGNIFIQAAEGFAVVTCVLGAANLIMSVFLFFFAPVVKFPLAVYFFLAAAAAVVTVGFALNLYLQGWCSAESLKASEWSLSLGFASFAISCGVSLTASVLVILSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RU65</accession>
    <name>A0A088RU65_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_241670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699506.1">
        <property type="nucleotide sequence ID" value="XM_010701204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RU65"/>
    <dbReference type="GeneID" id="22575576"/>
    <dbReference type="KEGG" id="lpan:LPMP_241670"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240024000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_241670"/>
    <dbReference type="eggNOG" id="ENOG502QWMK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277172at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="469" mass="51699" checksum="A82E24B93AA319F4" modified="2014-11-26" version="1">MPPGKGFVKEDPLAFEKPANTDCYKMGKHGIPYTSAGGGEVYSDGTVSGLLRSVYEYLVDEHHRPSYSSTMIRGPDLHTRPPAWLEDKNTAIDGSPLTTVERNAPGYWSVAYKKELEVAEAIQEVKRQRRYEQENDLVGFMNCARRYFGLSPLLDEAAARSHVEARHRLEDEARRLRLSTALGASGDEVAHAEEGCGASSSPHPIGTLPRSGTAQSLADIPQQRSSEYGENDVRRTGRVLSAPWLALMESVETGRPLTRVVNEYRPHLDYYGLDPFLDSAPSVVWSSTKCGIAIGLAHGTTKAVQAMNVEVQFLKASGVGVLSILNMSVFASVVKWGGNTAILACAFCVGDRLMRRIKLYTLPPHDAQRRSTSNYAMGLSFSGAMVGVLPWWVLNDTRLAMRMAASGFAIGGALGLIVGLSIQQLVALNTERLDATNRQLRRYEALLARQREWAEQVRSKYTSTAYVWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUD3</accession>
    <name>A0A088RUD3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_280940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700434.1">
        <property type="nucleotide sequence ID" value="XM_010702132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUD3"/>
    <dbReference type="GeneID" id="22576539"/>
    <dbReference type="KEGG" id="lpan:LPMP_280940"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280014900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_280940"/>
    <dbReference type="eggNOG" id="ENOG502S5CJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270315at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="176" mass="19939" checksum="9C3A90A8B829FA38" modified="2014-11-26" version="1">MKTKLSVAPRKARKKISFNANRNKVRFIRVPPRSQNRKFWFTETQRIVKKGLNFEVEPEIMIEVNIECRMQITALARKPLSQLGKGPAANGIEGAAASSSLASLAKRSYIELEETDPLFLPDARKRNRWQCVGSVSSGEMTKVRIVMPPGSYRMRCTGGDVVQVFAQSWDIERELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RV40</accession>
    <name>A0A088RV40_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Acyl-CoA dehydrogenase, putative</fullName>
            <ecNumber evidence="11">1.3.8.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_282660</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.-" evidence="11"/>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700605.1">
        <property type="nucleotide sequence ID" value="XM_010702303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RV40"/>
    <dbReference type="GeneID" id="22576711"/>
    <dbReference type="KEGG" id="lpan:LPMP_282660"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280033100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_282660"/>
    <dbReference type="eggNOG" id="KOG0139">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251155at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000031">
        <property type="entry name" value="Acyl-CoA dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000080">
        <property type="entry name" value="Probable acyl-coA dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000077">
        <property type="entry name" value="Putative acyl-CoA dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025878">
        <property type="entry name" value="Acyl-CoA_dh-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052166">
        <property type="entry name" value="Diverse_Acyl-CoA_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42803">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42803:SF1">
        <property type="entry name" value="BROAD-SPECIFICITY LINEAR ACYL-COA DEHYDROGENASE FADE5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12806">
        <property type="entry name" value="Acyl-CoA_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="9">
        <location>
            <begin position="108"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="8">
        <location>
            <begin position="191"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="7">
        <location>
            <begin position="312"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Acetyl-CoA dehydrogenase-like C-terminal" evidence="10">
        <location>
            <begin position="514"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN99898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="629" mass="69040" checksum="47DDF0B4E256E97D" modified="2014-11-26" version="1">MFRRVGSSPVARRAAALSVAARSLIYTPRIRDMKFLYEEVFNMYDHYKELGNSAAGGSDNIVTKELMDALLEESSKLATQTLFPLYESSDSEGCVLQDGHVTTPKGFKAAYQALAAGGWTSVNESEKYGGQGLPFSVGFTTREIMATANWGFSMYSGLSLGACRTLMSWASEELKGQYLPKLVSGEWSGTMCLTEPQCGTDLSQVKTKAEPSGDGKSYNITGTKIFISAGDHDLTENIIHIVLARLPNSLPSTKGLSLFLVPRHVVNRNGSLEAAKNVECSGLEKKMGIKGSSTCQLSFDKSVGYLIGEPSAGMKQMFTFMNAARMGCALEGVCHAELAFQNGLQYARERRSMRALGGAKEPEKPADRIICHANVRQNLLFAKAVAEGGRALLTDVGRLLDMHAAATDAVKASALDHEIGFYTPIAKACVTEWGVEAASRLLQVWGGHGYIKGNGMEQILRDSRIGTIYEGTTGVQALDFIGRKVLSTKGGNQAKRFGKRVSKLAWAHLFSTGALGRYARQLWLMQKHWRIATTRIGMMALKNRDAVAASSEDFLMYTGYMVLGYYWLRMAEVAQRKVAAGQDADGFYQTKLDTCEYVFTRILPRVEAHKRIMQAEPTLCAYKEENWDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVY7</accession>
    <name>A0A088RVY7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha</fullName>
            <ecNumber evidence="4">2.5.1.58</ecNumber>
            <ecNumber evidence="3">2.5.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">CAAX farnesyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">FTase-alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ras proteins prenyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Type I protein geranyl-geranyltransferase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LPMP_291960</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.58" evidence="4"/>
    <dbReference type="EC" id="2.5.1.59" evidence="3"/>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700801.1">
        <property type="nucleotide sequence ID" value="XM_010702499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVY7"/>
    <dbReference type="GeneID" id="22576959"/>
    <dbReference type="KEGG" id="lpan:LPMP_291960"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000009400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_291960"/>
    <dbReference type="eggNOG" id="ENOG502QUT9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272289at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005953">
        <property type="term" value="C:CAAX-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004662">
        <property type="term" value="F:CAAX-protein geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF1">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE_GERANYLGERANYLTRANSFERASE TYPE-1 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AIO00144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="756" mass="85362" checksum="453E92B8BF8487DC" modified="2014-11-26" version="1">MSRSNRSSSSSSSSLSSWVSASSAYSQSSKDGEWLYQLACVEAFVPLVADVTPADESSHALPEHPVAKIHYSPNFSFIYGVYRSLRDQLDYTPILPAHGEQCGSGELPPVIHAIHTSAARWFLLLAFALRQCTSNYTVWKDRRDVLMSPAVLEQATRDALPAFPVPEAILSCTASEAEKQEALRKLDEQQKKLRLTSQHWLPARADILWEGRPSPWRAVHWELAAVGCFTRLYHKNFQVWHHRRELLTYALQQTPSYVRCSADAAAADGKPEQQAEDSSPLVPALASEATLSDYLRRHAGLDFSAIDERPTLRAVLCNEDGKNYHAWLHLSWYLQAFSFLLTPPSREALEEHAIKLTGAVDDQESYFTPHPGWITASESAAPAALSPTLPPSPLTEELQFTAQLIYQDCRNNSVWCHRFVLLREALFRRLWRQLCSDRYTSTVGTLPTNTNWQRTARIVCAVEMNYSLQWLYVDPTNEAAYTHTRSVALLFHILTTRQHVWAAEHARTDGSEELQRYLADAPLLTPVALTNSELSANADAGTVCPFTELLHLLRDRQRCVPWDTYVESFGLLRYMQRVLHTVISARVTELEEQAARILRLAVASDAITSPGQEPKPQAIAALAPLYERSSQYMLDSFHQVDSAQYLVCQAILEEMWLTYMDAAQRRRVRQLRPSEAYREGLLSEWLRPCPWGGPEKSAADVGKLKDRQDAVVLNFLAYEAAALSKAKQLTMADPIRLKYWKREALNIMCRVYGTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWC7</accession>
    <name>A0A088RWC7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_292540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700858.1">
        <property type="nucleotide sequence ID" value="XM_010702556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWC7"/>
    <dbReference type="GeneID" id="22577017"/>
    <dbReference type="KEGG" id="lpan:LPMP_292540"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290027700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_292540"/>
    <dbReference type="eggNOG" id="ENOG502SEEJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="250383at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="67" mass="7337" checksum="BC80E004DE564333" modified="2014-11-26" version="1">MRKNISLKEFSTTPTVSYMLSKDGHNVAAAAGTQDCSMNPPPQPLLAERPKQQQPAPDGDDAMYEME</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWW4</accession>
    <name>A0A088RWW4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_281010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700441.1">
        <property type="nucleotide sequence ID" value="XM_010702139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWW4"/>
    <dbReference type="GeneID" id="22576546"/>
    <dbReference type="KEGG" id="lpan:LPMP_281010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280015600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_281010"/>
    <dbReference type="eggNOG" id="ENOG502QU6Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000943">
        <property type="entry name" value="Oxidoreductase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:001229">
        <property type="entry name" value="Oxidoreductase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF2">
        <property type="entry name" value="OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="967" mass="107662" checksum="F9CA4B2B35F0FB4E" modified="2014-11-26" version="1">MADHRKQPCQNMVEDETAAEALVEGEEEVPLCQHNEYDVTLSLEDREAKWGFSLSELQSAVKVVRVLFYNPELYVGDPYLSDSRLYTMITRDRKTKRENRNTFKAIMSEEKSRRKRYLRQQDIEAVRRTAMKRERDEALSALLLTGSEEAGNRVAPLLLVERPKVPELTGSEHGDDGLKDEAAGAASAANGNAEFYAGNVSLSASEKEVLRLVGAFENLLRLEQALRGEPVEGYEGVSAAPAATAANSSAAPSSSVAYPPVTGGEDDPFAPSMSSCTSVKKSRRETEASTTAPTAELDWLVITQLTAQVYRYLPHSYGSQMPPPFFDGAVPADAVNSPLEVRSYVRGVKCDVARRAAALVHLASETTPHNLLATAGGTEPVSLCSLFASTHRDIIVRTPLAELQSIDGLRSLMEGDQPSTASSQMMAVVDVPLDDLLRALELVLLEGASDKRFCPVPAAAEGDSEPEKERARTQQLCVAEQTLHCFIARRLYGSAKVRGCGPSPVLIQRNPPTSSSEEPDGYCIYDDVQRYAVELPEDDTQLKLSKFIGCHICKVRYNRLHPYYYSMCHLCGEYNYNKRLMARDLRGRTVLLTGCRIKIGYAIALSLLRCGATVLGTTRFIHEAVARFQQEVDYRLWKDRLHLFSLDLRDMWVVTQFCAFVRQKYRKLFAIINNAAQTIARTPQYTEHLRNIELNPPVALQTSIQHDACAAEWHNFFCHHTTVTVGQPLSIEYHPSLKPFLDTDQAARHDDAGAKRGNNSAGPQPGIAASEMPLLVDNNVVALHVGCDRTLIFDRYDTQAEESDHREKNSWVMNLAEVQGSEAAEVMAINALSPFILNGRLKVCLTDHQGDAVPNEPRFIINVSAMEGQFYRFKQTTHPHTNMAKAALNMMTRTSGDDYAAAGIYMNSVDTGWITDESPKLKKDRRTEQFMLCPLDEVDAAARCLDLIFTNSRVYGMFYKDFKEIVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWZ9</accession>
    <name>A0A088RWZ9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LPMP_303220</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701344.1">
        <property type="nucleotide sequence ID" value="XM_010703042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWZ9"/>
    <dbReference type="GeneID" id="22577375"/>
    <dbReference type="KEGG" id="lpan:LPMP_303220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300037100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_303220"/>
    <dbReference type="eggNOG" id="KOG0926">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17982">
        <property type="entry name" value="DEXHc_DHX37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003770">
        <property type="entry name" value="ATP-dependent RNA helicase DHR1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000637">
        <property type="entry name" value="ATP-dependent RNA helicase DHX37/DHR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002147">
        <property type="entry name" value="Putative ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF99">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="178"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="544"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="455"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="62"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="465"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="506"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="540"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AIO00544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1026" mass="116101" checksum="D8B111D956016C32" modified="2014-11-26" version="1">MPKKAAISFADLGLGAPLPRVLAKSRDERRKEQRIEKKERKDRTREAMAEVATARDIVAQHKRFVEAEAAQARKLKEMHKRELRVEHLKARSKREESERQRTTQLRVRQEEIITELKAKRREEEAEIQRVRALLERDTAERAKVAPINVHIDIHRTDEVKQQRAGLPVLREEQPIMEAINETRRTCVLVCGETGSGKTTQIPQFLWEAGYGHPESHTFGREGRILVTEPRRVAAVSMARRVAEELNAPFGEEVCYHVRYDNNLSDKCKLKFATEGIVLKEIQSDFLLRKYSVIVIDEAHERSISCDILIGLLSRIVPLRNDLFEEELRKHHGDVDKTSIKPLKLVIMSATMRVTDFKDNRMLFPIVPPLINVEARRYPVTNHFARRTELKEYVNQAFEKVRQMHKKLPPGGILVFLCTQQEIEDLCDRLRRHYATTKIEYCDNAYSKHRLLTGRSQEETAAASSDNDDDDAATAGEAEEKDEYGLHTADYALDDEDMTSGNSEEVETVREGRLRRPPQPRDGKGKRTRGEAGAQLAGRDPWGRSGEDRGAAAEGVTTFPGEEEEEVNGEYDTLHVLPLYALLDFQKQQEVFKPPLKGTRLCVVATNVAETSITIPNIKYVVDAGRAKSKVIDEETKASCFRIEWTSQASAEQRSGRAGRVGPGHCYRLYSTAVYANLMARHGDPEVLRTPLDSVVLLMKHIGVKNVGGFPFPSPPRESDLKAALQHLSVIGALDAAHNYNITELGRHLVAYPVPPRFARALFEVLKQQKAQSAEVQDMVAAIVAVATTTANVFTGEGNQLKAKKLDERADTPMDPRQAHIRSLVSPGSDLVTYLNAFYAYRSDPWRSCGMFCLVSKSMHDANLLYTQLRSHMRQHCRSQDELVDTLDESEATILEKDEQKLGSRHSGVCPLPRETELLLRQVFIPGLMDQVARRATVHECRSLGVVYNDKRATTTPYLVLGVNRTIAYIHPTSAVARTFPPPEYVIFGFLQKVHRSDTKETQAMMMGVTVVMPEWLRAYGFEEEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RX73</accession>
    <name>A0A088RX73_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_311470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701538.1">
        <property type="nucleotide sequence ID" value="XM_010703236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RX73"/>
    <dbReference type="GeneID" id="22577573"/>
    <dbReference type="KEGG" id="lpan:LPMP_311470"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310020800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_311470"/>
    <dbReference type="eggNOG" id="ENOG502SMJJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265794at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="409" mass="42965" checksum="6856A362B0A3903B" modified="2014-11-26" version="1">MSMWQVSSVDGICDNDHHNYNAFAWQRLLSNLEFESKSESTSVDELNTAPRSCPIPTIGSKQSNASAKDRVLPVKLDAHRTSSFAGSTIALQDDGYSSEEEHDSPDDQVASGSSPTPFYSSPTTTAITKGGNGGCVASIQSSSDATVPCFFVNGVRHSIEPLRKTPDWTAVPSLSSASQAKTVSMESPPWASAHVDPSTTPPKRVVAGSHSGVPSEGLCTAKSTTPLHSWMTPPLYATPGTLPTRHAIPASLPSSRMGNGAQSPFPILPESSTAYMANTASIMQPLPTSAMPVAQQARTPSFFSSNGSAANTTDSPALSFVFMDREGCFHLAPQGCAPPASALSALPMMHVSGGVTASPGMPQLQYTPSTIQAQSWRPTASLPCTASSGPWGSTKAWVFRDGSWMSLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYE5</accession>
    <name>A0A088RYE5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Rac serine-threonine kinase, putative</fullName>
            <ecNumber evidence="13">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_300850</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="13"/>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701120.1">
        <property type="nucleotide sequence ID" value="XM_010702818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYE5"/>
    <dbReference type="GeneID" id="22577139"/>
    <dbReference type="KEGG" id="lpan:LPMP_300850"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300013800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_300850"/>
    <dbReference type="eggNOG" id="KOG0598">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05123">
        <property type="entry name" value="STKc_AGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000008">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045270">
        <property type="entry name" value="STKc_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="106"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="12">
        <location>
            <begin position="360"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="415"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="415"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="462"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="500"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIO00320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="510" mass="57452" checksum="E8DA16CF2952BD69" modified="2014-11-26" version="1">MSGYLKVLSQDGSWETRYIEIDNTKLYIWRTKGDKESGAAVVKELDLKCATLREVSEPNTWAVQPEKAEATYFQADGEGRKTEWMDTLRHYNSSNIGSEKVTLRDFEKKFVLGKGSYGKVFMVVKKDTDKWYAMKEMSAEKMRQAEIKAPFAERIILEEIDHPFIVHLHYSFQEQGNLYMILDLLAGGELFTYIEQHAPLDEEVVKFYAAEVALALGYLHSRNIIYRDLKPENVVFDHEGHACLTDFGLAKANVHEPNAVTYCGTNEYLAPELLKGVPHGKAVDWWSLGLMMCEMLFNDLPFYDENPMQMQMKILTEDVAFPSHIQITEETKDLIRCLLNKNPERRLQTLEEFKAHKCFSNLDFGLLEGRKLKAPITPDPNPAHNFAKEFTSEVIVQNESPSQAIVTLAGYTYDRDSSEQEKSPSHSPTIAEELRQRRASKKTSSSGSEAVSPPVTGGKRTSNSSSAGASAKQAATGPIKKVEHHIPAKVAPQAARKKLTQNSSFDKAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYG4</accession>
    <name>A0A088RYG4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_321040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO00991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701791.1">
        <property type="nucleotide sequence ID" value="XM_010703489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYG4"/>
    <dbReference type="GeneID" id="22577845"/>
    <dbReference type="KEGG" id="lpan:LPMP_321040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320015500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_321040"/>
    <dbReference type="eggNOG" id="ENOG502S1I7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="250880at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="555" mass="59360" checksum="C0F5CE6C48353A63" modified="2014-11-26" version="1">MSAMNDLFDDELRTNVLTDPSLFLDIEDDDENVTVSDALPTPTVFLKLPQEHQQSEASLTTSGQGNGVPKLDVTALNSSPPQSSQHPIAGLMVPAASKSPISFSNDLNLDHTPADALMKGTAHSSSQASSPKNTSQSLSSVNVYANIANSLLCARSLPFRDFLNQKSVPPHIENEESTGIFVGQIPSSYAEEDIEALLKAIGHERGKMVQVRDVKCHNRDRTCAFIMINAGALTAILDFTKRVLCDLNCVWIVEHSQAAQLPLFIQQMPREQLRGVPKAALVLEKLTPQSKSRHSSSKSNVTTSPNTGYVTMQNGLMSPMQQSMVNMVPPTVFVQQQGTGASAAPAAGYLDVSALQATSPFVGTNFVQAAHGNGLPQFFDTSRFQPGAPTGTVFSPSGVAPCPSSVYAMPVSNNGIANIEVANQMLLAAPRSFAEFNSHQLNRFPPSPLQKESSAPPPKPTMVTLQPTLQSEHCSCGQMLLLSQYLEMGTCAKCQCVISPNDVAYWCVSGHIAVCANCALKSNKAPSGQDTTGRGMSTDSKSKRVDVGVTRRAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYI4</accession>
    <name>A0A088RYI4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein serine/threonine phosphatase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_321740</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701859.1">
        <property type="nucleotide sequence ID" value="XM_010703557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYI4"/>
    <dbReference type="GeneID" id="22577915"/>
    <dbReference type="KEGG" id="lpan:LPMP_321740"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320023000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_321740"/>
    <dbReference type="eggNOG" id="KOG1354">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6274823at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000009">
        <property type="entry name" value="PP2A_PR55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11871">
        <property type="entry name" value="PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00600">
        <property type="entry name" value="PP2APR55"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="255"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="459"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="271"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="474"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO01059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="923" mass="99671" checksum="56E66ADF421C74BE" modified="2014-11-26" version="1">MEPRKAVEKVHPKLSPSPEMPTGEQAQLKSLRSSRASSEARSEPGPVSQLSGPFQDAQMAACRSSRAGSEAPQRDRIGASPTSATRRDPYASYRGSRAGSEAPERGPAYEPSEERSARSSRAESEMPERGVYHDSVIQSRKRTPAKTKQSPMMMTASNASRTALRSMRADGVVSGARRQRHGAGGYAGGRVPQSVREHIRNVEQRLYGTVRGATTTFQFYQKLHYPLEDPHAGDEAQLEDDATVADCKAFSESMASLGDRKEPSPQPRLGSHNTRTTTEIFTVTSSPAARDDGSDSSAHTAASAVGTSSSGHHSSPSYSSVAAAAAAAAAMGTPSNGNGGSSNSPSPRFDEAAFATSFASIGSLDESGEMLTESFRIPLQAAGEDSALQSVSVVAMATLLDPLSGAPVLGLCLGDYSGHIEYFEVSTADTYNSSIRRSKSLMQQQQQQEGRASLTMQMYGGGKTRGSLRHSSDDGTATTATPNNCGSLDSAATENITHDMRGREVLRRHSHKAFVKSINALTSVAVEPYVKCLTFVRPRCSPSMISYLTANERVIKLFHVRREGFSPFNAFVGMEEVIGKTFVGSRYFARLPPQPAILPIKEFGPVMNSIQALSVSADGETFMSIEDLQVFWWSFEATDTTKATCIADLRPPSGALDEVEELVTAASFHPTHSSLFLLTRSSGILNIGDLRDPPSRVNRKYAISSQLTTQQNPFSCQAYDEILCSISGASFLGPDHVVTRDYLSLKLWDLRKPDRACAMMPVMNYVSKYLDTLYENDSIFDRFPVAVDDISGTVVTGLYDGAVAVWQPLHSSLSTANSLVHYRADPFVEPDDAASGGVVAVQELEVSLANAWSQTLSATHHSQLSSHINDENDSGVGLAEEAIPEPFTNKVLTVAIAPGGERFCYTYKNGRLVYIFERKSDMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYJ8</accession>
    <name>A0A088RYJ8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Kinesin, putative</fullName>
            <ecNumber evidence="10">5.6.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_301480</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.3" evidence="10"/>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701175.1">
        <property type="nucleotide sequence ID" value="XM_010702873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYJ8"/>
    <dbReference type="GeneID" id="22577201"/>
    <dbReference type="KEGG" id="lpan:LPMP_301480"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300020100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_301480"/>
    <dbReference type="eggNOG" id="KOG4280">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="540783at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00106">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000579">
        <property type="entry name" value="Kinesin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF36">
        <property type="entry name" value="KINESIN HEAVY CHAIN ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="5"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="728"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="911"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="432"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="728"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="754"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="788"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="806"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="861"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="91"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIO00375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1201" mass="132296" checksum="C273DFFD7A56CE46" modified="2014-11-26" version="1">MSEQRITVAVRIRPPIGRERYEPMCVRKADDNQTITITAEETSANVSGASTFQFDYVFDEADDQVSVYDESVQETVDHALSGFNATVLTYGQTGSGKTYTILGSKSSNGKVTAESGVFMRVFDDLFMYKESVKERIHIIITLSALELYVEDVMDLLSNKRKLKLRETPEETITIGINTVEVRTMADVERNFDIANSFRSVTATKMNDTSSRSHALFFIDLFQVQVEKSPQLPELSQLVDETGMSLSKGIPGVIKSRIALVDLAGSERVKRSGVTGQAMVEAQAINKSLSTLGTVINAMYLQNSHIPFRESKLTKLLKPCFVDTNSRLLLIGQVAPPSNSASESLGTLRFCDRVKGLKAGQVMGFSDPAAEEAFLRSRRANEELLAEMRILNAQYYYEVVSVRRLAAAKGVSVDQERQRVVAELKAGAADLVERKEREALEKAEREVNAQRDAEVERFVLHMNNLIEEYEQVAYAVKKEKKALKKLREEQGAEQEAQLHEAKKSKKHRLKMQEAIAEAQQSVEAMVCEAETLNRQIEAVKKETAAGAIDDVDDAAPPNKAMSSAVEEATHSLVESFYNHVAEQSRLYSMFVSRLSATRLERSRVRRMKLMSSTLVTEGTLLYDLIAFLVERAVDVSEGNALPGAKWGWFDVDGLSRRLLCGDEMYPPMLPSEFEQLDAEAQPCHEEPHKVTFLSSDESDGENSHHAAESRRIRQIRDAAASAKAENLHALRSNDMEGRGHGSSSGGSSDGDSDAGRSSGKGSAPASAPHGHQSEWMDGQLVRGTPPPDAALAVADTAEDAPPVAIKSDGRSKKKDAISADSGAAGVTSSSEKNGAVAASAAQPPKTRSGRHDKARNVAPTVAAASDGSASDAFGDESSGTEASSSPSESDGEDESAAARKAHKKKEREAACIARDIDEDELPVDAPNPSYQEKDSRALMKVYDSPTLVQDLIRFLRSGSRMTKHCRRGKPHQRIFWVSTQRGKRELFWKEPDSRSADYSCIQLSDVSFIQLGCFGKVFSRHRIPPTDPAFFRAFTIGLKHGGRTVDIVAETLPDYEAWVVGLSHLVAVDPVWGGKIDLTLEVGTDRLTYFESSVCEANYIHPLEYLELKRRVQYVAKRTMQVMAECGNDTVRAQAILGGIHPPAVNGNCAVYMTKGEMRFLLADTFDIIRVSRLWMLFQQMNLVYDDNFTPATAFGITQRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYL4</accession>
    <name>A0A088RYL4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_323290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702013.1">
        <property type="nucleotide sequence ID" value="XM_010703711.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22578070"/>
    <dbReference type="KEGG" id="lpan:LPMP_323290"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320039400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_323290"/>
    <dbReference type="eggNOG" id="ENOG502S8JX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267734at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="746"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1339"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1464"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="746"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1341"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1357"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1400"/>
            <end position="1409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1508" mass="160497" checksum="47587A858C1225FA" modified="2014-11-26" version="1">MHILGGASESSALDHEAHLGEQPIRELVQLPAKRPQVPSELSFHSSFFSYTIDSPSWGEPRLTSKSPAFTMSSSRAASPRSRTPSQRTGSLSPQSQPVAPASLSAVREAERRLDMKDEKTFLLSSSLSSSAVLGGTCCTTSQLTTPSLTVPLPLVAARTMATQVLPRCTDVEGQHHSRASQLPRTSSPPSSLTSRTADRPWGEEYELRRSGSSAKEPGVADTVLTLPLAALGEVPLPTPRLSSSSFSASLPAVSPLSALAASFSETPSCTPLSHLATTLLYTDDADPLADELRAESRINAAALSWVPLPLPTIPIKKSRLQRRAATRPPHLGDYSDAQCVSEVGAHPAVKQMWTRRKTKKGAVPTGEVVSVVQGGMLTPATLPQQPSSAGRRRTSSKAATRGTDQSAFATMASNAAEPVPIPGPAAALNQSEVREGLRSLTESSTRHSPAFRTDLEHLSLSATFPKQSKRHRQQELAVLADDVPLFDLFATGSYLSANATSMAPAACQSPVTPLVSPLSQGERLKRTRCRMAGVPQAAAAGVEDRAAPSAGRVAVETRRDGADTASATAASLPPPLSSPSAPQVLARSEELEGGGTGHTLPASGGFSTAPSRSETGGRKTPTSSPTLLVRKGRKSQWTPAASTDTPSCSGDGSSNDCNGVVTQAVSSVKCAADMQPSPLQAWWSAVCTSGSSSESGRSCLWIELAEGYQETHETLLRQVLVYWGCLHRESCVNSCGALELPINASPLSSSSPSNCSSRKRARNRKRTETNPASDIAPLEDAGRRDNNGLVVLLCPSSLPMEEALRWWTQRTHVEHSFMPPLLAVSMSVDSSSSAARRADRVPSVSREVPTLEEEHELFRGAIEQASRMYCTDPARSLAVSCSAAGHAALTQVLSLGQVFENLQVCADVLRSAAGFPPTSSVVKTLLEEDADVGSLTAALAVTAPTRDTRSSNAGERRCAASLQDRCFAELCRWNDLAAALQRQPRRPLLVLRRMCVDTLHRNDGTSKAPPKGAGVTGSLSTLMGDSKGVLSTSSVACSSLLSQQRRQWVMYGMVLPATRNEDTFASSVCREDRVLASQPPPVALAPLYLSALHLFGRILFASHNYATAVNVVESYARVSQRCLSDYLSGYSCVATGPLRYAVSATIRRYLQVRVQVALAPLLALVSEGTAAQQLTSTRPSASGACVSLPSIPISLSPVVLLARSTWRTVVPSLSCTCNPHLYEQVPRTDDGVKVCRHLAELFHYFITQQFSVVAHQAEPKEQSLQRQQLQSAPTGVDAMPFSRSPQASLCTTLLKKRQLSRCSRSHTSTNNFSSSASHTLSSLPFPVPYASSPDLYAGSERTVRKQERNEAPESESTDSTSSTGPSAQHHLLQHSVTTALSPAKRSNAPRTRPSKMAQRSSPVEAANASVASSAGTSAAGTDFHTQALQYALRLLHERMRDGSGGRSADGGAVSLAAAATGECDSLFHTSGPPAHVRKRTRSDGGTSREAERVRALQLVEQLLRDQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZ51</accession>
    <name>A0A088RZ51_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc finger-domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_303530</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701375.1">
        <property type="nucleotide sequence ID" value="XM_010703073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZ51"/>
    <dbReference type="GeneID" id="22577406"/>
    <dbReference type="KEGG" id="lpan:LPMP_303530"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300040200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_303530"/>
    <dbReference type="eggNOG" id="ENOG502QQDM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051252">
        <property type="term" value="P:regulation of RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000003">
        <property type="entry name" value="Zinc finger CCCH domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045877">
        <property type="entry name" value="ZFP36-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="CCCH ZINC FINGER/TIS11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547:SF18">
        <property type="entry name" value="PROTEIN TIS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="93"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO00575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="266" mass="29502" checksum="86E0F686F6639D20" modified="2014-11-26" version="1">MTFSVKGGNYSSSHPSPVMHPYVSPSLLPQSHGQQAPPSFSLGDEQYVGVPKRVGVDPTKYKTTICRNWEQTGTCNFRGCTFAHGVEELRAPLRPDGHTPVLRPQHLSPGNTPPLRSSQAPPPPSSGHYTLEQLLDMLYKEVLHQRELVAVHVEANTTLEGMLRREQAQHGVSKRKLEEKTQQCELLAKELFARNQQLRNAADSSPEVKGLLDQWEAQLVSFSEADTKKDDAFYTAPATSSTDDGGKTGKDYESARIEELLRALQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S049</accession>
    <name>A0A088S049_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RBP22</name>
        <name evidence="5" type="ORF">LPMP_341270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702553.1">
        <property type="nucleotide sequence ID" value="XM_010704251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S049"/>
    <dbReference type="GeneID" id="22578632"/>
    <dbReference type="KEGG" id="lpan:LPMP_341270"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340018700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_341270"/>
    <dbReference type="eggNOG" id="KOG3152">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="287393at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034462">
        <property type="term" value="P:small-subunit processome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039119">
        <property type="entry name" value="ABT1/Esf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311:SF7">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="16"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="196"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="118"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="166"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO01753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="232" mass="26697" checksum="C8C2088633C718BC" modified="2014-11-26" version="1">MSLLGVEHYAPPSQRGVLYFNTIPRDMRPQEVRLHFNQYGEVRRMKFIPFPKKARRPGGPLLPLQYKEGWMEFTSASDAQHAAQCMNGQPIDVKRQRRCYGQLWTVRFMEGFTWDSLLEEAEAKRRAWRAAEVEARKEERSMNEAYRRMAMQAEQQRRAKRRHREVRVTSHSDVDAHDDVGRPLVATDNGALCICGGTGRGATANSATTPKVHSAKKSERDATKKLKKRRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0A3</accession>
    <name>A0A088S0A3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phenylalanine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_320930</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="3"/>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO00980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701780.1">
        <property type="nucleotide sequence ID" value="XM_010703478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0A3"/>
    <dbReference type="GeneID" id="22577834"/>
    <dbReference type="KEGG" id="lpan:LPMP_320930"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320014300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_320930"/>
    <dbReference type="eggNOG" id="KOG2784">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="238316at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000133">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase alpha chain,putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040724">
        <property type="entry name" value="PheRS_DBD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040725">
        <property type="entry name" value="PheRS_DBD3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003210">
        <property type="entry name" value="PRK04172.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF40">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18552">
        <property type="entry name" value="PheRS_DBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18553">
        <property type="entry name" value="PheRS_DBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="352"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIO00980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="500" mass="56676" checksum="B92B5F99D7E9AD7B" modified="2014-11-26" version="1">MTEQVSIEATILKALSSTERVFSTDVAESIGADHQDVVGAGKSLEADNYIHSEMEQRMVLKLSSEALQIMESGSPEYRVWSLLKDDKMSQEDVASKLGKEATGVALANGIKSKMFKTTKEAGKVFLERVPGSENVVDTVRELLKETAAAANQIDAKAMETLKKRKLAAMEAKKVFVYTKGPSYAVERAAKAVGDLTREMLADGSWKERQFKEYNFSAQGAEVGGGALHPLLKVRQEFREILMELGFQEMSTQHWAEVSFWNFDSLFIPQQHPARDLQDTFFLSKPETSNVSDLEYVERVKAQHEESFRTPWKLEEASRNVLRTHTTGSSAFVLKNLAKCAKRGPDGKLHFTPGRYYSIDRVFRNEEMDRTHLCEFHQVEGCVIDRDISLAKMMHTFDSFFRRIGVSQLRFKPAFNPYTEPSMEIFGFHTGLNKWIEVGNSGLFRPELLRPMGFEDDVAVMAWGLSLERPTMIKYGINNIHELFGHRVDIRSIKRAAIARY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0X9</accession>
    <name>A0A088S0X9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dynein light chain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_342980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702724.1">
        <property type="nucleotide sequence ID" value="XM_010704422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0X9"/>
    <dbReference type="GeneID" id="22578803"/>
    <dbReference type="KEGG" id="lpan:LPMP_342980"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340036100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_342980"/>
    <dbReference type="eggNOG" id="ENOG502S1D4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10033309at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21450">
        <property type="entry name" value="DLC-like_DYNLL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000014">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="174" mass="19650" checksum="2212676BE454943F" modified="2014-11-26" version="1">MATSSTAEGAVLERTLRPGQRHSNAERDHSNSSVLSDMHAGNGFPDGGAEEEDVELDIRASHVHMEALYVDVPAKELQLIMDSALRAYNTHVFIPTRTTWRKEEGSRRELERDVERTALSRIAEDIKKDITAKLGGRWHVIYGHDFATYVTHKRLCFCHFQIEGADVVVWRHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S105</accession>
    <name>A0A088S105_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_342750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702701.1">
        <property type="nucleotide sequence ID" value="XM_010704399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S105"/>
    <dbReference type="GeneID" id="22578780"/>
    <dbReference type="KEGG" id="lpan:LPMP_342750"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340033600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_342750"/>
    <dbReference type="eggNOG" id="ENOG502RX7N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269683at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO01901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="734" mass="82033" checksum="9433B7659E6C9AC1" modified="2014-11-26" version="1">MRFAGTSSIDKATFRRLWTSLPYEQLERSFWVALEAFCEPFLDSNSPLNSPTFFSVPQTGRIVQKDLPLVNEDIVRACNELRPLYTTFTLWNPLALAALLKTPIEVVTTQLLLAVQQSWMSVYFVICCRSCGCDIAHFHSVNDIPFIGTFHSTNAFRCPMCTDRTEVKELRDVAVFFQLQRLPALFRRQHYRLYYTKEADERRLESIFCPGQAGFAFTAHLPKGRYLLSAPFCGAFVEISVDLSAEVMGAKDPYLSHIVDLKTYIRSQNSTADPFGRPIKRRSTIRHVLPRRGITSAGTVSSDGLGGGGAQRLSIACGSRFSMSDTIHSEDVVKSITGFGSEDVEEMPPISVISLKHGKVQFRIYNSTPHSGFVDLFVALDTRTEFSANPYPQLFHVPHFMHCLPRGLRSSFLTRCIPRPPSTTPTTGAYVRHQFVLSGEQADDPNIISVLREVHRYSLEDHYGLLIGVGDGGTSFESTFLSTTAALASSICFFQRVLTRLGETVALAMRCSVTEGPLKIAAYQGQYNDAHNTRSSYPDAQFVGAVVYASNHPPISGPYLYCTEVEPPTAVVAATTDDETGKEVVTRRVGVLDKYRSPAWLHDENSSYYDNINSRDNHAPNKMSVSKATQQEVQCLIRFEVRYVSSTIDCDTGTCLRRTSVCPQLPLKENGSGSTDNIFPYFLEFLREHFEGTSLKEEPHALVVQIPLPMIYASLQMSTILDKKAYTKEQLGPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S138</accession>
    <name>A0A088S138_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_323680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702050.1">
        <property type="nucleotide sequence ID" value="XM_010703748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S138"/>
    <dbReference type="GeneID" id="22578109"/>
    <dbReference type="KEGG" id="lpan:LPMP_323680"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320043700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_323680"/>
    <dbReference type="eggNOG" id="ENOG502S6E6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="259656at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO01250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="302" mass="33869" checksum="545596F40186C1FF" modified="2014-11-26" version="1">MGRTPNHEPPAAIKPNEELTDADRREMAELGIGEGAFNRILTSCIKFTFSSGWSVRKRDAEYDILWETKLSENCNKQAMRFTAHVPNCNTGSLEAILVDDKNFDDDPSVSCMYKYDRLLLQNHVQKRIAGNITVQRMNYRSPVPLVSPRQMVTYTTLGALLTPAQQKELGIRPTGLNNEAADADRTDSLMAFIQCGVDYTGDEVELKKGSELGHVYNYSVLGLEEPDGSMTVIMTMDMDPAGRLPAKVVDMASDEQHKKMQLIVELLKEKGKQPHLCRVYENTRDFPFRDDSTQSKEGGELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1A8</accession>
    <name>A0A088S1A8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Long chain fatty Acyl CoA synthetase, putative</fullName>
            <ecNumber evidence="2">6.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_030220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.2.1.3" evidence="2"/>
    <dbReference type="EMBL" id="CP009372">
        <property type="protein sequence ID" value="AIN95256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700964.1">
        <property type="nucleotide sequence ID" value="XM_010702662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1A8"/>
    <dbReference type="GeneID" id="22571888"/>
    <dbReference type="KEGG" id="lpan:LPMP_030220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_030007000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_030220"/>
    <dbReference type="eggNOG" id="KOG1180">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17639">
        <property type="entry name" value="LC_FACS_euk1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020459">
        <property type="entry name" value="AMP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF105">
        <property type="entry name" value="ACYL COA SYNTHETASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00154">
        <property type="entry name" value="AMPBINDING"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="116"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="704" mass="79329" checksum="C53242BBD6B1BC04" modified="2014-11-26" version="1">MGAVLSYYFKKRNKVSEVDFPCYREYDAYGQQSVPVEGSSASDRSMIYRMAKTSNADFERLRDEWYKGGTCLSVVEAICKMRGQATCLAYRKLREIEKSETTTADGRTKVLETYVFEPGLRTISYERLWKCVINFGRGLQEIGLKKGEIVSIYEETRWQWLVTLYSCWSQNLVVSTVYANLGEDALQYALAETQCRAIVCNGTKVKDVLQMFELIEAPKHTKIIYLDELPSPVTSEEYDVHAWIDLVLLGEKSEARHHIPNGAENKDDLALIMYTSGTTGNPKGVMHTHGSLYSGCMTINHRITDLLGEMTVQEWYCSYLPLAHIMEFAVTSVLMMRGVIIGYGSPRTLTDTFAKPYGDMTAYRPYIFVAVPRVFDTMKKAVEAKLPPPGSIKRKVFDKAYKDRLKALKSGRDTPFYNKKVFFAARQVMGGRVHAMLSGGGPLSASTQEFVNVVFGMVIQGWGMTETVCCGGIQRTGNLEYNSVGQVLNTEELRLLDTEEFKHTDQPEPRGEVLLRGPFLFKGYYKQPELTKEALDEEGWYHTGDVAAMAPNGTVRIVGRVKALVKNANGEYLALEALESIYGTNEVTLPNGVCVLVNSHRSYITIIALTNEALVNAFMKKHKITTGTFPSILKDKEFLNKVLFSLQKTGRDAHRSSFEIVQGVVLLDDEWTPENGVLTAAMKLKRRVIEERYADAIKELFEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1E3</accession>
    <name>A0A088S1E3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA-editing substrate-binding complex 6 protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_350440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702983.1">
        <property type="nucleotide sequence ID" value="XM_010704681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1E3"/>
    <dbReference type="GeneID" id="22579073"/>
    <dbReference type="KEGG" id="lpan:LPMP_350440"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350009700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_350440"/>
    <dbReference type="eggNOG" id="ENOG502QTJU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275750at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="CDD" id="cd23735">
        <property type="entry name" value="RESC6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058917">
        <property type="entry name" value="RESC6_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26188">
        <property type="entry name" value="RESC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839186" description="RNA-editing substrate-binding complex 6 protein domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-editing substrate-binding complex 6 protein" evidence="2">
        <location>
            <begin position="101"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO02183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="482" mass="52677" checksum="21D365630414C161" modified="2014-11-26" version="1">MRRLLTCCPAAAFAVARTLTTSSFVASIEQVQQQLQTAQDRRTELLRYGRQLYEVEVLDDLKVAYTPALASKVCYVASQLRIDATKGQPYTAVLEASMTAKGEQAMDVASLARIVHSCLVLRSGNLHEVLFTFIPFLCEKAGMMDAVTTAVVINAYGRSGVHHPRLYKALCDNGATVLKDPRVALAHIANVAYAVSRVKFLHPTLMLTLRDHALRKVAEASPIISLTILEAFTELRQIDEDLFSSYEQRLLGQLNELQAPLMASLVSCVVRAGRGRAEVMESLGVRTTALADTFDAASIAKVTNAYYEADIASEDVLGALAERACKVAADFRADEIATVLNALSSFDLFDAELFPLLASRLVALHRQGGYVDVADAAIILSSFAAVQERNDELIYVCTQLFATCPGVAMDPVVRVNALWACASLNVHNEAQTNMLEEARATPSLVMWESKPEMLPKTKATLKERSQFLTKVYGITFPSSSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1V1</accession>
    <name>A0A088S1V1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Dolichol-phosphate mannosyltransferase subunit 1</fullName>
            <ecNumber evidence="16">2.4.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">DPMS</name>
        <name evidence="19" type="ORF">LPMP_350210</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15 16">Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a di-trans,poly-cis-dolichyl phosphate + GDP-alpha-D-mannose = a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + GDP</text>
            <dbReference type="Rhea" id="RHEA:21184"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 16">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.83" evidence="16"/>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702961.1">
        <property type="nucleotide sequence ID" value="XM_010704659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1V1"/>
    <dbReference type="GeneID" id="22579050"/>
    <dbReference type="KEGG" id="lpan:LPMP_350210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350007100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_350210"/>
    <dbReference type="eggNOG" id="KOG2978">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2603at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000119">
        <property type="entry name" value="Dolichol-phosphate mannosyltransferase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398:SF1">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 16 19" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="18">
        <location>
            <begin position="4"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00053724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU365083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AIO02161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="262" mass="29730" checksum="3FF5CDB1EFF95E01" modified="2014-11-26" version="1">MQYSIIVPTYKEYGNLEPLTRRVFAAVKEQGLPVEAVEMLIVDDNSCDGSKEVIEKLHQEGFNVRIDVRTVERGLSSAVIHGLHNTTGVYKVVMDADLQHPPESVPALFKALRCDGVEFVCGTRYGAGVVIDKNWPAHRRLISWGARLLARPLTTLSDPMSGFFGIRDDVFKRHAGEVNSIGYKIALELFVKCRVQRFAEVNFHFSIRTYGESKLTGKVIFNYLQHLYALYLFQVGPLFYTLLAVTVMFVLYLVVFLYHSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2C4</accession>
    <name>A0A088S2C4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Generative cell specific 1 protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">GCS1</name>
        <name evidence="14" type="ORF">LPMP_340420</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAP2/GCS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702470.1">
        <property type="nucleotide sequence ID" value="XM_010704168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2C4"/>
    <dbReference type="GeneID" id="22578546"/>
    <dbReference type="KEGG" id="lpan:LPMP_340420"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340009500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_340420"/>
    <dbReference type="eggNOG" id="ENOG502QREH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272303at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007338">
        <property type="term" value="P:single fertilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040326">
        <property type="entry name" value="HAP2/GCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018928">
        <property type="entry name" value="HAP2/GCS1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31764:SF0">
        <property type="entry name" value="GENERATIVE CELL SPECIFIC-1_HAP2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31764">
        <property type="entry name" value="PROTEIN HAPLESS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10699">
        <property type="entry name" value="HAP2-GCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0278">Fertilization</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="661"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="Generative cell specific-1/HAP2" evidence="13">
        <location>
            <begin position="144"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="699"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="852"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="707"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="857"/>
            <end position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIO01670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="905" mass="97684" checksum="F9043CECEF294891" modified="2014-11-26" version="1">MYIVTPHSMVTKNAMLHHRVHSAQDGKSGVLPSSRLTSLATVCGCLALALALVALMPASKGGLVVMTLWACGMAHETVRTYLAAPPRCSLCRSPPLRRHAVVHGTVYVALLWVFLLVWLAQPARAAFASSSLISYCSDSGDEKINCKKKMVVTVTVEGGQLPDEESLLFLNSATDMTIKNGTAVQFSPIRITTSRSAVRYRYPLFYVQNYNTKPYEATVKGSLLNQCNADFDTNTATCGIAHDAAGKPILYSQGFCCDCSMCQTLGLCLPDARANAGCNIFDRYTTASCLRFTKRWYSGYTIGGYVTWYTVNLTLSRNVSVSGGAGSAEKVVTQKVVMHLSPSSNGETAGEEWDVMARVLGNYAPIVQPLDLTSRMLFAPAIPPNDERVQAGAAEWMLLPTNLVTLDGRECDKVGVSYEAFASQGNKCNLRPGSCLNSQLEDYRTTDLERIASGNKGQYMATSFGDFHLERDAVASPYISYRATSPAATMLSITISADDLEYTVGLASGKIVSAELNKPVLEASTKDGVMTVVVRNAASVTGRVVVGTSSCSDGVFPITAQTLSLAAQQQSTVAFNVYMQDSYASENASCMVVLRNAQEVITDLRTVSWKVSSTSFHNGTQGGSANPDGGTTEASSAASCSKCRTLDVACAVQRRCWQLTLLYLFVYLLLTAAVMCAIWLRHIFCCCFYFLNRQHRRHHPSGSSGVEPKDEASRLRSCSKGHDRSGAASSFRRTDRDNSDSVDAPPRTATPASPIPPPGPAMMYIPTSMYYAASPTGSFALPQHLPSPPSVLQPPTPMPPLGWCPYNNEGTAIPEEDLRAAQAFPPYSPSGSFVSVAPSVCSASRHGEEWGVRDNVESISPLTPSRSTQEGSPQNEGDNTPRAFRRSWASTLRQSPLPEVHAPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2J5</accession>
    <name>A0A088S2J5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Exosome complex exonuclease RRP41, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_353090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703246.1">
        <property type="nucleotide sequence ID" value="XM_010704944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2J5"/>
    <dbReference type="GeneID" id="22579338"/>
    <dbReference type="KEGG" id="lpan:LPMP_353090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350038400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_353090"/>
    <dbReference type="eggNOG" id="KOG1068">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27298at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000047">
        <property type="entry name" value="Exosome complex exonuclease RRP41A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF0">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="2">
        <location>
            <begin position="22"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="3">
        <location>
            <begin position="155"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO02446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="246" mass="27109" checksum="B6072B9606AA87BD" modified="2014-11-26" version="1">MSRQKEYVSPAGLRLDGRRPLEARRMDIVFGTLSACDGSCDITVGQSKVCASIFGPRESLHKQEAKHDKVLVTCEVAVAAFAGESRRNPQRRSKLSEDIDAAVVQVARSVILLSQYPNSQIHIYIEVLQQDGNEKVACINAACLALVDANVAMRDVVCCISVGLLDEHMLIDLANDELRSQCPVIVAAFTGHDTRNIIWLETTSRLPPDSVARLLKCAEQGAQELFETTIRKSLEEHAKKILTLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S337</accession>
    <name>A0A088S337_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Paraflagellar rod component, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_354900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703421.1">
        <property type="nucleotide sequence ID" value="XM_010705119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S337"/>
    <dbReference type="GeneID" id="22579518"/>
    <dbReference type="KEGG" id="lpan:LPMP_354900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350057400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_354900"/>
    <dbReference type="eggNOG" id="KOG4840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271876at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013744">
        <property type="entry name" value="SidJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591:SF1">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08538">
        <property type="entry name" value="DUF1749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO02621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="317" mass="34089" checksum="53DA3929554813AF" modified="2014-11-26" version="1">MEGRLITLPRDGNHKTSIFLSGTAQRCILVVGSQAEGLFATPYTKQLADGLREEWAVAQVVLGSSHVGRCAPGLEADADDVDAALAVLVKEYNMTEIVLYASGTGVQVALEVLASTLRAGVVTRVILHGGIVSPQQSALFSVKATKQRVEVAHALIAERRGDDAAAMAQVYDMTITPARLYRNATLTVQEAVWQPVLGECESTCKQTLRGVTVPTLFLLSTESSYTTTAQGALSKVLRAVRDATGLPTEDVQVTLLPTTIDEHRRFLKGNTELAVQTVSDFLQQADARHEQRKAAAAIMAIEAERNKRIAHVKALCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3I4</accession>
    <name>A0A088S3I4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Isopentenyl-diphosphate delta-isomerase, putative</fullName>
            <ecNumber evidence="12">5.3.3.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_345160</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homooctamer. Dimer of tetramers.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="12"/>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702935.1">
        <property type="nucleotide sequence ID" value="XM_010704633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3I4"/>
    <dbReference type="GeneID" id="22579021"/>
    <dbReference type="KEGG" id="lpan:LPMP_345160"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340059800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_345160"/>
    <dbReference type="eggNOG" id="ENOG502QTHT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25826at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02811">
        <property type="entry name" value="IDI-2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00354">
        <property type="entry name" value="Idi_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011179">
        <property type="entry name" value="IPdP_isomerase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02151">
        <property type="entry name" value="IPP_isom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43665">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43665:SF1">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003314">
        <property type="entry name" value="IPP_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="9 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN-dependent dehydrogenase" evidence="11">
        <location>
            <begin position="186"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIO02135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="357" mass="39396" checksum="68136860B0D737C3" modified="2014-11-26" version="1">MASPDCMADREAAVQKRKKDHIDICLRKNVEPRKGSTSIWSKYTLPYKALPEVDLRKIDTSCEFMGKCISFPFLISSMTGGEAHGRVINENLAKACEVEKIPFGLGSMRIINRYASAVHTFNVKELCPSVPMLANIGLVQLNYGFGPKEVNNLVDSVRADGLCIHLNHTQEVCQPEGDTNFEGLIEKLRQLLPHIKVPVLVKGVGHGIDYESMVAIKASGVKYVDVSGCGGTSWAWIEGRRQPYKVEEENIGYLFRDIGVPTDVCLRESAPLTVNGDLHLIAGGGIRNGMDVAKTLMMGASYATAAMPFLAAALESSEAVRAVIQRMRQELRISMFTCGARNIEELRRMRVIELSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S4D1</accession>
    <name>A0A088S4D1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_120030</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the proteasome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009381">
        <property type="protein sequence ID" value="AIN96331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696984.1">
        <property type="nucleotide sequence ID" value="XM_010698682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S4D1"/>
    <dbReference type="GeneID" id="22573009"/>
    <dbReference type="KEGG" id="lpan:LPMP_120030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_120005200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_120030"/>
    <dbReference type="eggNOG" id="KOG0174">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7854943at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03762">
        <property type="entry name" value="proteasome_beta_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000073">
        <property type="entry name" value="Proteasome subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF0">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE SUBUNIT HSLV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6 8 10" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0888">Threonine protease</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN96331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="283" mass="30343" checksum="50AEEE92F0E278FC" modified="2014-11-26" version="1">MLQRPDHTLLQDPSYPKDTRQKLTENGPAQAAKELFPADAAIIDPQLSEAVSLGTTILAVSYKGGVVLAADSRTSSGTYVVNRASNKLTKLTKKIYCCRSGSAADTQALAERVSNYLGSYQTDVGTEVNVATAANLFHKMCYMNRWNISAGIIVAGYDPINGSSVYSIPSGGSCVKLDYALGGSGSIFLYSFFDANYKPDMSKSECVAFCQRAVAHAFSRDGSSGGLIRTITLDAGEPEHQTIPWNTAPYCMEKDPKYQQQAVLHQSLSSSAKVTGNCMSSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S580</accession>
    <name>A0A088S580_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_357030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703630.1">
        <property type="nucleotide sequence ID" value="XM_010705328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S580"/>
    <dbReference type="GeneID" id="22579731"/>
    <dbReference type="KEGG" id="lpan:LPMP_357030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350080000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_357030"/>
    <dbReference type="eggNOG" id="KOG4619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="430821at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019537">
        <property type="entry name" value="TMEM65"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21706">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21706:SF13">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10507">
        <property type="entry name" value="TMEM65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="276"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO02830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="350" mass="38441" checksum="46D0B211F1593010" modified="2014-11-26" version="1">MSTSRMLRDAHSSFASGGTTAMVTTASTYASSSAPLTSDELQRIAQLIENDPRILMEVVARLDPQSRRRLVVAGGAMEWFGKESAAQEVEKADADQDRQISPKDFDHWFESALKRRQEEQKKRVTEGKQVTHAENGISATASTAPSDVPVSNTVPLAALFMIALEAALPFVGFGFLDNSTMILAGDMIDGSLGFYLNCSVLASAAMGNVCSGVLGMQVHGLIDNTVQKLNLNTPVLSEEQLKDRRVFLAGHLGGTLGIMLGLILGMLPLLFLDGDTNEKSDYAMFQRWDINHNGFVELPEFEKVLRELGLHQTDIRAKNLIDKYGENNRVNFEQFSQIKADLRDGKPIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S5N5</accession>
    <name>A0A088S5N5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Inositol/phosphatidylinositol phosphatase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_151140</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Phagosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697489.1">
        <property type="nucleotide sequence ID" value="XM_010699187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S5N5"/>
    <dbReference type="GeneID" id="22573534"/>
    <dbReference type="KEGG" id="lpan:LPMP_151140"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150016700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_151140"/>
    <dbReference type="eggNOG" id="KOG0565">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7862313at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04380">
        <property type="entry name" value="RhoGAP_OCRL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000128">
        <property type="entry name" value="Inositol/phosphatidylinositol phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047078">
        <property type="entry name" value="RhoGAP_OCRL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF300">
        <property type="entry name" value="TYPE II INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="5">
        <location>
            <begin position="587"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN96836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="792" mass="86889" checksum="9B2268D52B69817A" modified="2014-11-26" version="1">MYPGLPRAFPNPEWQNVEDIFRQRTAFGFLAPNARASATADPAMAADAWVQREIGYYEVNYTTVEDLSVCVTSFNVGCKKPVLPLTSLVCLTSSGGGTDDAPARPTDLIVVGMQEVDMSATALFKQETEAASPWVAGLNAAIGADSSSSTATSSSGGAGASPYYAFPPKQLVGLLLCVFIRRPLLSAVSEFSMATVATGALGSMGNKGAVGFHLVLHRTSICVITAHLAAGHDNVSKRNEDINTIFRSMDFNAARRAETQMSASPNAPIDESAFLEIYPRDHDIIIVAGDLNYRLRLPYETAVHLANSGQFSELLVHDQLAAEMKNPHTPWLNFINFTPTHMPTYRFDIGTDVYDTSEKRRIPSYTDRICVWSRRKSMESRIRLDRISALMEVRSSDHKPVQALARIPVSVEVPAQKAQIVSSLREKVATIGLAQASSAKISLSMSKVNFQAQCFHNCGTQEVVTVQNNGNCVAVVRVVRQREGDYSEGSWLRVTPQELAILPGESQDVQIETAFHPRCTLWMAAWRPYQGRGSIELSSVLLFCCRNGPVQAVECQCVLSPSVFGNALENIALLQDTPCVEAYAQKADFEEVVRQVRPHVPKELWYLVYVIAQHPREPGLFTRSTNKEVCRHIMELLDTKNAALPVDTDVHCAAECLLAFLKNLREPVVPYAQYTAALAAGRAKGKAPLQFLRQLPTMHANVWLYVLSLLNYLLRPVNNSDNELDAPLLAHIFSAVLIGRPTDAQGAIPARLQQGGGVDQQVRQQLQQESDDALALVEYFLSTPPSMLAGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S757</accession>
    <name>A0A088S757_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_190590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698054.1">
        <property type="nucleotide sequence ID" value="XM_010699752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S757"/>
    <dbReference type="GeneID" id="22574113"/>
    <dbReference type="KEGG" id="lpan:LPMP_190590"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190014700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_190590"/>
    <dbReference type="eggNOG" id="ENOG502SAV0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2160189at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.320.10">
        <property type="entry name" value="Hypothetical Protein Pfu-838710-001"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34948">
        <property type="entry name" value="OS08G0299200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34948:SF2">
        <property type="entry name" value="TRIPHOSPHATE TUNNEL METALLOENZYME 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="739" mass="80917" checksum="202794B4C58094EB" modified="2014-11-26" version="1">MQIEVKLSLEDAESYQRTLHTLANHHLGDEYYYDLFFDFPCSALQERSSVLRLRVPCDPAPVYAYSVTPAPSASAGSNSNYDPEAEYEALLRACRGKAPSPIDAAAASNVSACVHATTATANPGGDGVSAHGLPLPTFTPGALGKLILKQKNTVEQGHQMCFVVEDAHVPSAVVEALVRLVPEWLFTAGVVTSTKVADGGASDAFAVLSAYAQQHPCSDDGAGESAIVRILSQLNAVARDYALSNGTGAPASDPESSNTHFAQIRFAAMGTHATYMHQQLSTSQQTCDKKSGKMEDGDGAGGAAVVPRLEAVAGFMTLRKVFAYAPLVALQQASLKALDLTESEREFREGLRVRLDASYLLPGLTIYELEVPKCGVAVDDVATEVGNFLRQLGVAFHVGSESKFTRYTQYLAATREAEQDANDVKLRLTNVNGYEEVQRNLQQLILPAYAANAQSSQERRYISNTEVSLAEDEEAGDDRTWWHTNTSGYVKETNEDFFFDSPEQTLRRGKSFLRLRKQLHSNKYLLVLKAHQVFSGGQQNSLSSKVSVSEGVARALIENPTQFLHEYAEHFAVVKTVWKEFGVRELCRAATFTTERLTVPWWAAQVQQSTLQRSWASGASLALAQQSQSIHTTPCLLQQQQGCGVAGKPQPVPPLLIHLDRTLYRLPADAQAPRIPFSQCRSWGDRQCETYELEVTNIVAPTEPKDVVAELTAVLNRLGVEWTVGVRSKLEQYFSLMEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S7F6</accession>
    <name>A0A088S7F6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">malate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_200190</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3"/>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698218.1">
        <property type="nucleotide sequence ID" value="XM_010699916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S7F6"/>
    <dbReference type="GeneID" id="22574226"/>
    <dbReference type="KEGG" id="lpan:LPMP_200190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000028700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_200190"/>
    <dbReference type="eggNOG" id="KOG1494">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4069699at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070013">
        <property type="term" value="C:intracellular organelle lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01337">
        <property type="entry name" value="MDH_glyoxysomal_mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000268">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000009">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010097">
        <property type="entry name" value="Malate_DH_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01772">
        <property type="entry name" value="MDH_euk_gproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF16">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="5 10 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="11">
        <location>
            <begin position="10"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="12">
        <location>
            <begin position="155"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="15"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="123"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIN97511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="331" mass="35918" checksum="9246B42B5D8E79FB" modified="2014-11-26" version="1">MKQSTLSRFKVAVLGASGAIGQPLSMALVQNKRVSDLALYDIVQPRGIAVDLSHFPRKVKVAGYPTKWIHKALDGADVVLMPAGMPRRPGMTHDDLFNTNALTVHELSAAVARYSPKAILAIISNPLNSLVPIAAETLRMAGVYDPRKVFGLISLNMMRARKMLGDFAGLDPETLDVPVIGGHSGQTIVPLFSQSGVALKREQAEYLTHRVRVGGDEVVRAKEGRGSSSLSMALAAAEWTEGVLRAMDGEKTLLRCSFVESPLFADKCRFFGSTVEVGKEGVERVLPLPPLDEYEEEQLDRCLPDLEKNIRKGLLFVAENASTITPSSTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SA49</accession>
    <name>A0A088SA49_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ubiquitin-activating enzyme E1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_230710</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699228.1">
        <property type="nucleotide sequence ID" value="XM_010700926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SA49"/>
    <dbReference type="GeneID" id="22575275"/>
    <dbReference type="KEGG" id="lpan:LPMP_230710"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230014200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_230710"/>
    <dbReference type="eggNOG" id="KOG2012">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10252231at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004839">
        <property type="term" value="F:ubiquitin activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01490">
        <property type="entry name" value="Ube1_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.180:FF:000007">
        <property type="entry name" value="Putative ubiquitin-activating enzyme e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12550:FF:000005">
        <property type="entry name" value="Putative ubiquitin-activating enzyme e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000002">
        <property type="entry name" value="SUMO-activating enzyme subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000007">
        <property type="entry name" value="Ubiquitin-activating enzyme E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2660:FF:000005">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.180">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, FCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.80">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12550">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2660">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, SCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.60">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, UFD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042302">
        <property type="entry name" value="E1_FCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018965">
        <property type="entry name" value="Ub-activating_enz_E1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042449">
        <property type="entry name" value="Ub-E1_IAD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038252">
        <property type="entry name" value="UBA_E1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042063">
        <property type="entry name" value="Ubi_acti_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018075">
        <property type="entry name" value="UBQ-activ_enz_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000011">
        <property type="entry name" value="UBQ/SUMO-activ_enz_E1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01408">
        <property type="entry name" value="Ube1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF4">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09358">
        <property type="entry name" value="E1_UFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01849">
        <property type="entry name" value="UBIQUITINACT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00985">
        <property type="entry name" value="UBA_e1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-activating enzyme E1 C-terminal" evidence="9">
        <location>
            <begin position="910"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN98521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1045" mass="115522" checksum="F3F8E95CBB0B55B9" modified="2014-11-26" version="1">MLSEDEQKRQLYNRQEYVVGSETQARYGSTNVLVVGAKGLGAEIIKNIVLTGVKSVKVLDNAVVTIEDLGTNFFLRPDDVGKPRGAAVAQAAKELNRFVEVSSVSGDPLLHIPVVHVVIYTNAYTSTLTVANDVARENKVRFISCESRGVCGCIFVDGGESLDIVDSDGEDTVTCVVTALSSDGLVTLHEDKNHECETGSKVYFTGLSALPQANTTEPAVPSAWKLFEVAEVISPHTMRLKGIADLVSAGVVVDVGTSAYLHTTKKGRREHYRTLAESLHNPECLMIFDKEEKCVAAATLHAMFTAVARHGNVPTSPAEVETIVKVAQSINPGAEAPIMRMLLPVFGGDLNPMTCFIGGMAAQEALKVCSGKFTPLHQWMYYDAREVLQAWQYGAKTMSASALCSSAAVFPDAPAAPSRYAGQEAVLGHAFQQYLRQQKAFIVGAGALGCELIKNVALMGFGEVSITDMDTIEMSNLSRQFLFRNHHIGRPKSVVAAEAAGHINAEVKITPHEAKMAPETEVIFNEDFWAQQAVILNALDNVASRKYVDSRCLFYQKPLLESGTLGTKCNMQPVIPFVTESYSSSYDPPEKGIPLCTLKNFPNAIEHTIQWARDLFHLLFVSVPADVNQYLDNPVAFANNLRNDPAAADTVMHNVNDALGRWPKNEEECVRLARLLYQEHFNDGFRQLLHNIPLDKRTEDGQLFWSGAKKPPKPQEFNAGSEQDIEFVYHCACLFAKVYQLPPFSLSKEETVRQAAAVTVPHFVPRHAVFATSERQTSQQTSLSSGLTVEQLPVVTQFGTRRMRAEEFDKDDITNHHVQFITYGSNLRARAYNIPAADFNQTKRIAGNIIPAMVTTTSLVTGLVGFELLKYLLIQFHHARKSAAAGTGSSHGEKFYLDADEEPEKLVTLFRSAFVNIALPFIAFSDPIVAQSRSYALPSGKKLRWGIWDRLDISEGRDMFVKELVQLLRDRYELEVFMIALQNGKMIYTEFGGKAKDKEKRVSEVAQSKGETLLDGIDYFDLVVTGMIGDDDEVDVPIIRYRYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SAJ9</accession>
    <name>A0A088SAJ9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.57</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_240110</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Displays methyltransferase, positive regulation of the poly(A) polymerase and transcription elongation activities. Involved in the modification of both mRNA ends and in intermediate and late gene positive transcription elongation. At the mRNAs 5' end, methylates the ribose 2' OH group of the first transcribed nucleotide, thereby producing a 2'-O-methylpurine cap. At the 3' end, functions as a processivity factor which stimulates the activity of the viral poly(A) polymerase OPG063 that creates mRNA's poly(A) tail. In the presence of OPG102, OPG063 does not dissociate from the RNA allowing tail elongation to around 250 adenylates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with poly(A) polymerase catalytic subunit OPG063. Interacts with OPG109 and OPG123; these interactions might help linking transcription to capping and polyadenylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Virion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.57" evidence="2"/>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699353.1">
        <property type="nucleotide sequence ID" value="XM_010701051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SAJ9"/>
    <dbReference type="GeneID" id="22575420"/>
    <dbReference type="KEGG" id="lpan:LPMP_240110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240005900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_240110"/>
    <dbReference type="eggNOG" id="ENOG502QTMU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270189at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004483">
        <property type="term" value="F:methyltransferase cap1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20760">
        <property type="entry name" value="capping_2-OMTase_Mimiviridae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000744">
        <property type="entry name" value="Poly A polymerase regulatory subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000176">
        <property type="entry name" value="mRNA_MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025804">
        <property type="entry name" value="Pox/kineto_cap_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01358">
        <property type="entry name" value="PARP_regulatory"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51612">
        <property type="entry name" value="SAM_MT_2O_PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="413"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="422"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN98646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="437" mass="49624" checksum="CCAB00C1BEB51A52" modified="2014-11-26" version="1">MLFDRRLVLREDAPRRPYRSNVSTASFECPLLKGLHYGQRKLALSEVEFFLQIAMYAKNCSSAASLKVLVVYAGAACGLHLPFLFSLFPTLDFVLIDPAPFCSQVKEIASKEGSCVLELIEDFCTPELCLRIRRTYCETHDIFLVSDIRSGEPTGMSLNQEHTDMIQQDNYAQREWCFSLEVQAAMLKFHPPYPATKDSDLTSNNAQDTTAEEYTYLDGTQLLGVWAPKSSSEVRLVVVGPFKPGYEAPARRYHCTAHEEQCYAYNVDNRYEKDCAAERLILETYLSAFPDAYKSVEQLSKTLSEKLGYPLFCPLEPGFTEQHARWVTLLYSTGKPSALQYFELLKNNMSVAQVASLVSEHKDCSEIPADVKVGDVVLTPHFWSVFAAGDFAAVYCFPVVRWRWRQQAYRHRLSNKQDGSKRNHRRFAGKKRTANAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SB18</accession>
    <name>A0A088SB18_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Vacuolar protein sorting-associated protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_242140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699553.1">
        <property type="nucleotide sequence ID" value="XM_010701251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SB18"/>
    <dbReference type="GeneID" id="22575623"/>
    <dbReference type="KEGG" id="lpan:LPMP_242140"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240028700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_242140"/>
    <dbReference type="eggNOG" id="ENOG502QQZ9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270484at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990745">
        <property type="term" value="C:EARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019514">
        <property type="entry name" value="Syndetin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040047">
        <property type="entry name" value="VPS50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019515">
        <property type="entry name" value="VPS54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13258">
        <property type="entry name" value="SYNDETIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13258:SF0">
        <property type="entry name" value="SYNDETIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10474">
        <property type="entry name" value="Syndetin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10475">
        <property type="entry name" value="Vps54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 N-terminal" evidence="6">
        <location>
            <begin position="97"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Syndetin C-terminal" evidence="5">
        <location>
            <begin position="774"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN98846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1016" mass="112572" checksum="443CCCB8B493B5B5" modified="2014-11-26" version="1">MEDVTESLAAAWKEAMKGVKVGYKKTKSVLKQIPVDRLKAISGAGGVMSHADIRRFFQVKYGAEVRNTEGEPVAADEVSDVESSDEEPLTDAQVHERVDKKFFDKTYNPAKFELEHMDNFAYTDDETEGRVMREAAEGKIRELRQKCNTVSTTLKRRVLAHHHAFVSGTEKIRDINDSLLMTSSDCKKARAAIRRSKTSVASQVALLAQQRTKENVEATIQLLEAMKAMCDKRTQLMNLISSGKVHEAAGFLKREGSIDMENSLTKIYCMKSVMAEWRLYRDNSKKLTDCIEVVLADCLTNKFIVPRYCNALEASQHLGCAAETCASVATLLWRTAVQILCKSLTEVSFMKNENAPLADIAENIHPDYLILGVRQMAAKLMDFLYLYSTVVRLHEEERHTNSPYAGLHNQALQRLQDMGQRAGRDLVEKLTVVLSSVRLASIDPDRVLHLFVVVSMLTEAFGVLGLEKTEQAAARTKTKAVLLRHMQMHFQTPKAHEVLAFMAEDDWTVSAVSPQSLSMVKPLSPNNFKSFVKEVKHYLHQGVDDSLLAAGTMPFMENPFLTQKILEPADTSSLVQTQTFGAYWATVNTGRAADVTGDSEEFASPTDNVGPGVEAAPLSAPVGSQNTATLASSVGMPPSVLTSSAISVTNAFLEYQARITVRFPPLAADILGWCEELLCLYFYTVVDSFVSVSRSVPIEHQGDFSVTAQRVLAGVRAAGERAVGAVNGQYTPKDHDRHLYGGGGVGSTSVSTSRFPPVVWGRLSNELTSAAQQFAVGNRTVACQSVLSLILFYEATIQTISPLLPVTVTQPYMQRCRMLYGAAHEVLHVCIHRLCQAILPVESVCNNIAKLKGSKDEVTVSSYVGQLVGSMKTLNEQRVPMPTPALESVFLQRLIFAAQAVLVREYSKLSKKRMNDFFVMQLQVDVQSFQQQATSIFGKSSVVMPDYVLRMVKAGFFASEKAQCLKWVRSNHTLYYSVDLVSWFGAADRPFMLQLEDLLVRELKHQDILPMDGFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SEW5</accession>
    <name>A0A088SEW5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DREV methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_301150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701147.1">
        <property type="nucleotide sequence ID" value="XM_010702845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SEW5"/>
    <dbReference type="GeneID" id="22577169"/>
    <dbReference type="KEGG" id="lpan:LPMP_301150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300016600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_301150"/>
    <dbReference type="eggNOG" id="KOG3987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="199041at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106370">
        <property type="term" value="F:protein-L-histidine N-pros-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007884">
        <property type="entry name" value="METL9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12890">
        <property type="entry name" value="DREV PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12890:SF0">
        <property type="entry name" value="PROTEIN-L-HISTIDINE N-PROS-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05219">
        <property type="entry name" value="DREV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO00347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="307" mass="34935" checksum="41845543B6FA9F69" modified="2014-11-26" version="1">MQGLSKDLKLYTSGHRGRPALIYEPRMNLVSPSFVKLFEACNCDTETTAFLVRYRNISLWKLLLADLLSLFFSRTTAHGFVGRGTMFVYSTEQIRRLLRPPQTPPTSPLPQDFQFDSLLDIGAGDGGVTSKIAPLFKTVYTTEFSASMRWRLRRRGYEVLPHDDPFHINTAGKLQERRYFDVIACNNVLDRADTPRTLLQEIRDSLKPNGFLVLAVVLPWCPFVENGPRQQRPNEVLPMEGGECCRGASFEASMSKLVENVLVPMGFELIRWTRLPYLCEGNLRLEYAVLNDAVLILRKRGDITSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SH18</accession>
    <name>A0A088SH18_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_322180</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701902.1">
        <property type="nucleotide sequence ID" value="XM_010703600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SH18"/>
    <dbReference type="GeneID" id="22577959"/>
    <dbReference type="KEGG" id="lpan:LPMP_322180"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320027400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_322180"/>
    <dbReference type="eggNOG" id="KOG0058">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF503">
        <property type="entry name" value="MITOCHONDRIAL POTASSIUM CHANNEL ATP-BINDING SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="173"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="493"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIO01102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="730" mass="77785" checksum="61FC6A3FDDE5EAE7" modified="2014-11-26" version="1">MSTAKLADSNSPSVPMVSSPTTAPAEEAVGTWQLVQFAYRYMVCEQRIILVSGFFMACATLLSISIPALAEEIVSYGMETITKTLNGVSHTVEDSRATSPAAAPGVYGLGMSAEGADQFSFLGLGALSERICKPLLPIFFAVLRVVCGAVVVGTGAEAAAWPSPYVEGILCRCLLMAMAIACYHATSLLAHLAAYYAGSGAQNALMKDSVHRILLTLHPERVTVVSAVKLAQLITASGRALSDTTGELLTNVLSQVMYTVGFFAVMLFLSYQLTLTILVGVVLVQCLFFFQGMSLHRQGCCVTAEEASVQSYIANVLQRSQTVLVFGCSDFVLSRMADRLAQVRRLTNSLNRSIHGYTAVSSGLTRLILVVALGLSNYYQQKGQLDMRHTILYFACFQSFVNTLASLSSSVSQLRATLGRLRTLHSILRWYSEPLAVTTGEGGAAATPEAVVDVQESASAAVDLDHVSFSYPEVPAFFSEVNGATGAGNAVAALEKHLGSAMGSQHSNGVSQVSITAVVGGITVLYGPSGCGKSTCLRLLCGLLRPRTGTVHTQRRVVLLEQQHAIFMGTVAENILLTNLSDLGTSMADAGASKPMLPLGHVPQSPTAAAAFAELHRRVTDAAAKSGCASFLKNPFSTFIESVDHPQFSGGQLQRIALARVFAQTDGYSLVLLDEPTTGLDRNAVELLLESIRELRDTHHKTVLISTHDHRVAEVADKVIDMSTSAVETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SHE3</accession>
    <name>A0A088SHE3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chaperone protein DNAj, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_323480</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702032.1">
        <property type="nucleotide sequence ID" value="XM_010703730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SHE3"/>
    <dbReference type="GeneID" id="22578089"/>
    <dbReference type="KEGG" id="lpan:LPMP_323480"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320041400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_323480"/>
    <dbReference type="eggNOG" id="KOG0712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000013">
        <property type="entry name" value="DnaJ subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839508" evidence="6">
        <location>
            <begin position="28"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="56"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="8">
        <location>
            <begin position="178"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="5">
        <location>
            <begin position="178"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIO01232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="402" mass="45062" checksum="9D4F15AAA96F5AC1" modified="2014-11-26" version="1">MVATIVCSHRAVVRCACALALLLVCVALNSNAFFDFGGGHHTDASKAQVRRGPEVDYYKVLQLEGKREEVTEKDIRQQFRRLSRLYHPDVAKTEEDKAKYSQVNRAYEVLSDKRKRKIYDMRGEQGLAQLEELDRTKGSPGGGMNPLAQLFGMRTDNGLRGPDMELEAKVDLAKLFTGGQDILRINKRRVCQACKGSGADATAAVVQCRQCGGQGVLRQRIQLAPGMIQEVHQRCTSCGGAGRRPERVCPVCRGRKVMQGSSTIVLELEPGMTENSVLKFEMEAEESPDRLPGDVVVRVHTHPHPVFSRRRNQLDLDTSLTLTLKEALVGFDRNITHLDGEEQVRVYRRDTVSPYGTVLRLQGKGMPKLHVPSERGDLYVRLQYDLPARLTKEQKELVEKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SIC3</accession>
    <name>A0A088SIC3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNAJ family-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_332810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702372.1">
        <property type="nucleotide sequence ID" value="XM_010704070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SIC3"/>
    <dbReference type="GeneID" id="22578434"/>
    <dbReference type="KEGG" id="lpan:LPMP_332810"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330036000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_332810"/>
    <dbReference type="eggNOG" id="ENOG502SK9X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051100">
        <property type="entry name" value="DnaJ_subfamily_B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908:SF3">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="45"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="267" mass="29383" checksum="E8590655633387D2" modified="2014-11-26" version="1">MDSTTTTSSRAATDAERLQQQQQQQLNSDASQSPHITKDNIDTFNYFQLFGLVTPTTSSTATAAGSNGGGNDVTLSVIDVAAVRRTYRRLSLRFHPDKDDSDEARHAFEVVRTALETIIDSTKLAAYVKTLDAACGGAGSGGHPGEEARQRQRAQQAHVEAEWAADMLIQRAQERLAKEAATRQAAQEREGAAQQLLSELTSSLNTPFQLMEAELVRDWDVDEEMVSMKTKEVMKLLHQLASADSGWIPHFMQEGASRKRGRDYTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SJ50</accession>
    <name>A0A088SJ50_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_342260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702652.1">
        <property type="nucleotide sequence ID" value="XM_010704350.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22578731"/>
    <dbReference type="KEGG" id="lpan:LPMP_342260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340028600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_342260"/>
    <dbReference type="eggNOG" id="ENOG502QPZU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF1">
        <property type="entry name" value="CANNONBALL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO01852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1790" mass="193588" checksum="7D8B27BBDF788900" modified="2014-11-26" version="1">MQDFLTAASSHTAAVNAASVRGSPLISVADSSTAGEFESCCRALSHKANKAVVEQLPVLQNGSVVDLSRNYVGAAGLQAIAVVLPHNPKVTEVRAPRNGITNDAVVFLCRAMRGHPQLSMLDLSDNTDVSLAGGLALLSLAQQTPSLRVVKLNGTHVPAAVLHKLTRALEYNASRHDTISVRVVASQSTAAVVAPPSASPSRTAAATADEAQILQTLRARVEAALEEGYLFPPVSPQTGWRVLDVPILAPPLLFDTEVRLLCDEVFPRLNQKFSSYRVILRPVVVSGGAGVVKGDDEASDGVVRLRPHRTSESYNRALYFCPSCHVTSVVERGRFATIELVGDRPGDYVQLSASAMLRLQGVTQSAAQRMESNDDDEPKEAATPLQPVLYEAHEAALRCTQWLLVATRRDTRTLQMPAALAPLLTADPSIAHPDRHRSVVRAIVIGGEGPSPSTATAEKTAVVSSSAAIPTSLEWDYATEEYHWRRHVAWREHVVATAPVAELVVPQYTATFDGIDLQGGVRLKQLEGFQMAVYTRLRTVVEACVAAEARKRGITEAAEFAVGSKSLSLLLRSTGTQRAWDVTYLQSLAATSSGAAKKNLINRMVLYAANPPSRNMLLLHGTDAAALSSLMARGATRLQTLQHAYTLAAYTTRSSLLHEEPTELRSVMTHVVSQLTKNAAVLRYVNAEVDMERLSAFFLQLISGSVSSTNTSKLVHTSAATASAVTVMREAGLPDYVAQYTLGADGAVDAGSTASAHAFVVLLDGLEGFEMPVQPCGALVHPPGSGGNGTTGGGAEPTNWSTEMITTPAPCSAAPSAATLISKTQPKLHTTPMNALLPRALARHVRLIASCVSSSPAFRTLSHLGRDSVEMLSFGAVSANEVEQYLSPASLARVGLVFSEDDFECARSKRDAPNAEYMNYLLDATRSVHEAPGFLTQRQAIQAFPDTLQEAAQDVYGRLIHAFGLPVTRHVLGLLMASRWGLLLPELCDLLPSLSTCRLQELLRLLRPALEPEAPTEAAEVMGVRSGNVLLGAARLTAPSFLEVVKRESLRLVADELQVQNDQSVWHGQLAQYYLSIVYRWLRPGAAATTGATKVRRVDDAAAAEAFTCPDTQALQRRAMKEVIYHMTRSGGFWSKMDVTILSIPFLEQVYVSGLGYAYLRDLTAAFNERYERHLFGKDIEEPSWRQQQQQSAIESVRTGIGAMAAGDVQTRSTSDSAGSSRYALPAVLNRMRDYVCFAHQYGLLLSLHPTLLVQVALQIPANLLNAVQRDAVGYLYRQQQEKGGYGPDRGSLSRIILTPVTSAVATAAGKPSTHLGPIRCAAFLPNRRFVVTASSDRSLAWVNPESGTAAWYARQPTAAVESLTVCRTSAYVASVSEDRTVWVHDGLQGTLVSQFRGSKWFDAPIASLTFSARGRYLWVVTTDARVRCFACESGRLRWTMGLSELLQENVGELLPKGEKTPLVGADATATEERMHLNSAEWRHRRHYLHVLVDAEDDEVCTTVAATELRQWRLRPWDEPSPTSEEGHQPTTANTAAIACEMTMRCSLNRSQVCASNGPLGYKLMELWESATVRSPYMCVLAAPHSEPEVQLLTLQQSDGTALLVVRCLLVVPSSNHPGTTAAAHEVSLMRTSPDGQWIAVGMTGGAVNLFCISAAYCAWQQQQQIHAAVVCRPTCVYTSLMPTPGMSTAPLRSLAFHHAGHILFALGHSLVCWRLPDASAVTLQTGAAESVHHTPDGEYLWTHTPTCLAVLPPPTPSKSDAELPHNIAEVAVGDASGRVTLLTWWRQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SJI3</accession>
    <name>A0A088SJI3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_343530</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFB7 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702777.1">
        <property type="nucleotide sequence ID" value="XM_010704475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SJI3"/>
    <dbReference type="GeneID" id="22578858"/>
    <dbReference type="KEGG" id="lpan:LPMP_343530"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340042500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_343530"/>
    <dbReference type="eggNOG" id="ENOG502R9FS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268414at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008698">
        <property type="entry name" value="NDUB7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900">
        <property type="entry name" value="NADH:UBIQUINONE OXIDOREDUCTASE B18-LIKE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05676">
        <property type="entry name" value="NDUF_B7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIO01977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="225" mass="26473" checksum="E5B40DEB5EDB0EA0" modified="2014-11-26" version="1">MTEYLNDLASAKPGESMPPVNLGPYDNPLLWNKLDPFGADRGHQRRPMTVSRDFMELNQVPIVYRDHCVHRWIPFNRCMRNLKPVTWGTVNCHEFEESWMVCRAHETYRLQLLKSKFMELTKDYTAEDKKFFPSILYLGIPYYMPSFYWNLAASQRLSGWDEKDPANPVMWREPNRSLMRSEFSPTNWEKGTMTSAYGHKLIPDEIVYDMVPGFPLPEEKRPQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SJI8</accession>
    <name>A0A088SJI8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_343590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702782.1">
        <property type="nucleotide sequence ID" value="XM_010704480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SJI8"/>
    <dbReference type="GeneID" id="22578864"/>
    <dbReference type="KEGG" id="lpan:LPMP_343590"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340043400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_343590"/>
    <dbReference type="eggNOG" id="ENOG502QT2C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270350at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="440" mass="50425" checksum="EC6931CEA0FDAF76" modified="2014-11-26" version="1">MEIATMDPVAQRELQRMTQAIEQYAARLDSLGTELETVEQQNRNDDVSHQIQQYNKAAVAPQDIAAEDAMDNIVRMENQLKIVRRRNQLLARENAMQEKLLRDRANKLASSKKELDTVMTITGWYGGKRDVQFSQIERERADIHDMALVEASLRSEIKSSKATIAKLEKVVLALSAKILENEERRTEYMQLRNDCRVREKECSEMQAKAQRMATDNQKLQLVVRTESESTLVDRSVACMESDREFLSDAVQDMKMACRRQDNVIKAQIAREQQLQRRLNTVTKSLNEMRLAREFERNVAKSALVPSASREEPEDVAAVLPQAECIPVDTFRLLYKNNEMMRTSVARKNMLVLEKESVVQSMETKMAQYIGKHNEFVLLDDSMQMSGETAVRAAKRNFDAEENNLTRQIEDLRALNSEMRATLSKTAPPTHIRKPASNLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SKP5</accession>
    <name>A0A088SKP5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_352550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703192.1">
        <property type="nucleotide sequence ID" value="XM_010704890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SKP5"/>
    <dbReference type="GeneID" id="22579284"/>
    <dbReference type="KEGG" id="lpan:LPMP_352550"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350032100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_352550"/>
    <dbReference type="eggNOG" id="ENOG502RZR0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="245689at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="492" mass="52595" checksum="C845E2B3BC7C2258" modified="2014-11-26" version="1">MSVVTMLTKDAGCEESQQQKLKEDSKSPHTPSIHWISHEEQKGEKATNGDCANLLDWSPQTPETPPVSVAGLRVAPVADTAAAETTSESTTHDSEGRTKEGATSAYGHVEEPAGGVAAARGAAPEAAPQKTPERGPSVPGKHNHSYGASDVVSSSSSHVDALGNLIDSIETRKPNSTIRLNASGSSGDVEALRNTVAVEADDRLPPRLRDVFFPSAACDAVTAASLMTLISSYCNVVTLVQLMRVNRAVHRLATSDAVWYPLLVSMNLPPLLTAYERDRGCYNFFVEDIITTRALHGHYTFQATNTMSDTRGSVGATSRSRSVGMSHDHASRDEDSLEEDIFNIASLQLLISSASLGQSNHPIGRVQLLLTYKNESMEVLQGSCRFSVHRRCFSLCCSAFGTMKRGPVFTVAVATVTKPWANEDSQHFTEHKNGIRLVMTPVLWEGQSPGSQITENDILVVSRPKPVSSLTGSMTGSVGANISQGAPTGSHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4D5</accession>
    <name>A0AC62A4D5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Beta tubulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3320140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="XUY36722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="443" mass="49744" checksum="1E1DE6A6BC45CBBD" modified="2026-01-28" version="1">MREIVSCQAGQCGNQIGSKFWEVIADEHGVDPTGSYQGDSDLQLERMNVYFDESAGGRYVPRAVLMDLEPGTMDSVRAGPYGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELIDSVLDVCRKEAESCDCLQGFQLSHSLGGGTGSGMGTLLISKLREEYPDRIMMTFSVIPSPRVSDTVVEPYNTTLSVHQLVENSDESMCIDNEALYDICFRTLKLTTPTFGDLNHLVAAVMSGVTCCLRFPGQLNSDLRKLAVNLVPFPRLHFFMMGFAPLTSRGSQQYRGLSVAELTQQMFDAKNMMQAADPRHGRYLTASALFRGRMSTKEVDEQMLNVQNKNSSYFIEWIPNNIKSSICDIPPKGLKMSVTFIGNNTCIQEMFRRVGEQFTGMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATVEEEGEYDEEEEAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4L1</accession>
    <name>A0AC62A4L1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Beta tubulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3320260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="XUY36734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="443" mass="49744" checksum="1E1DE6A6BC45CBBD" modified="2026-01-28" version="1">MREIVSCQAGQCGNQIGSKFWEVIADEHGVDPTGSYQGDSDLQLERMNVYFDESAGGRYVPRAVLMDLEPGTMDSVRAGPYGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELIDSVLDVCRKEAESCDCLQGFQLSHSLGGGTGSGMGTLLISKLREEYPDRIMMTFSVIPSPRVSDTVVEPYNTTLSVHQLVENSDESMCIDNEALYDICFRTLKLTTPTFGDLNHLVAAVMSGVTCCLRFPGQLNSDLRKLAVNLVPFPRLHFFMMGFAPLTSRGSQQYRGLSVAELTQQMFDAKNMMQAADPRHGRYLTASALFRGRMSTKEVDEQMLNVQNKNSSYFIEWIPNNIKSSICDIPPKGLKMSVTFIGNNTCIQEMFRRVGEQFTGMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATVEEEGEYDEEEEAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4Q7</accession>
    <name>A0AC62A4Q7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NADH-dependent fumarate reductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3420110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="XUY36773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="543" mass="57545" checksum="4BC5586EA8412D02" modified="2026-01-28" version="1">MVSGTHAARLVLKKGHAKPAAPGRGRPRFPGRWRGMMATARGAQRLASDEAGVPHAKPRVLRHAGRFLLRGAPGECAARSRKNGSAWGTAVQKAAGVHDSGELFEKDTFASGKGGSCQPELVRTLSDHSAEAIEWLSSFGIPLTALTQLGGASRKRCHRAPDNPDGTPLPIGFTIVRALENYIRTNLSDIVRIETNARLISLMHSKEDDAVVVQGITYATQTASGEGKIRKLQARAVILATGGFSNDHTANSLLQQYAPQLSSFPTTNGVWATGDGVKAARELGVKLVDMDKVQLHPTGLLDPKDPSNRTKYLGPEALRGSGGVLLNKNGERFVNELDLRSVVSQAIIEQNNVYPGSGGSKFAYCVLNEAAAKLFGKNFLGFYWHRLGLFEKVEDVAGLAKLIGCPEENVTATLKEYKELSSKKLHACPLTNKNVFPCTLGTEGPYYVAFVTPSIHYTMGGCLISPSAEMQTIDDTGVTPVRRPILGLFGAGEVTGGVHGGNRLGGNSLLECVVFGRIAGARAAAILQEGGAGLPLQGGGQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4T1</accession>
    <name>A0AC62A4T1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3420450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="XUY36809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="298" mass="32271" checksum="66516F3123C82883" modified="2026-01-28" version="1">MGEKQSKGYWQEDEDAPTCNGCGCVFSTTLRRHHCRNCGYVLCGGCSRHRAAIPMRGITEPERVCDACYLALRNSSVIGSSLSRGNPEPIVNPSETPNRPAAWTAGGTTCGPSADLRASDAASLAAAAQSSSAAPELSEEQREAEAFYHNPYGGAAGGQGNSDTTGAADARQETINPEALEKKRLIQRWNTVRQATVYVDILVQQSERVEPDTAVEYSRETEALILEPELPINQLGTRMLPLPRPTTDSARYLVELVTTIGVTGTMLERAAADLTRRLVTRIPARADSRESPDRFVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4X3</accession>
    <name>A0AC62A4X3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Heat shock protein 83</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">HSP83</name>
        <name evidence="1" type="ORF">LPMP_3320100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="XUY36718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="705" mass="80923" checksum="AF830CB1B8703C87" modified="2026-01-28" version="1">MTETFAFQAEINQLMSLIINTFYSNKEIFLRELISNASDACDKIRYQSLTDPSVLGEETHLRVRVVPDKANKTLTVEDNGIGMTKADLVNNLGTIARSGTKAFMEALEAGGDMSMIGQFGVGFYSAYLVADRVTVVSKNNSDEAYVWESSAGGTFTITSVQESDMKRGTRITLHLKEDQQEYLEERRVKDLIKKHSEFIGYDIELMVEKTAEKEVTDEDEEEDESKKKSCGDEGEPKVEEVTEGGEDKKKKTKKVKEVTKTYEVQNKHKPLWTRDPKDVTKEEYAAFYKAISNDWEDPAATKHFSVEGQLEFRAIMFVPKRAPFDMFEPNKKRNNIKLYVRRVFIMDNCEDLCPDWLGFVKGVVDSEDLPLNISRENLQQNKILKVIRKNIVKKCLELFEEMAENKEDYKQFYEQFGKNIKLGIHEDTANRKKLMELLRFYSTESGEEMTTLKDYVTRMKPEQKSIYYITGDSKKKLESSPFIEKARRCGLEVLFMTEPIDEYVMQQVKDFEDKKFACLTKEGVHFEESEEEKKQREEKKAACEKLCKTMKEVLGDKVEKVTVSERLSTSPCILVTSEFGWSAHMEQIMRNQALRDSSMAQYMMSKKTMEVNPDHPIIKELRRRVEADENDKAVKDLVFLLFDTSLLTSGFQLDDPTGYAERINRMIKLGLSLDEEEEEEVAEAAPSEAAPAEVTAGTSSMEQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A539</accession>
    <name>A0AC62A539_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Succinyl-CoA synthetase alpha subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2520050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="XUY36908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="300" mass="30941" checksum="F8E0F3B0C1D939A9" modified="2026-01-28" version="1">MFARSAIRRWINRDTKLIVQGMTGKAGSFHTKAAMAYGTKVVGGVSPKKAGTTALGVPVFATTAEAVKATGATASVLYVPAPLCAASIEEALEAEVPLVVVITEGIPQWDMLRVKSMLLSQNKTRLIGPNCPGIIKPGECKIGIMPGHIHQKGKIGIVSRSGTLTYEAVAQTTAVGLGQSLCVGIGGDPFNGTNMVDCLRLFLNDPETEGIILIGEIGGTAEEEAADFIKNSPIKKPTVSFIGGATAPPGRRMGHAGAIVSGGMGTAKGKKEALRAAGVTVSDSPAHLGKHMAELFATKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5V8</accession>
    <name>A0AC62A5V8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amastin-like surface protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2020860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="194" mass="22191" checksum="6A5C0B5FCE518DDD" modified="2026-01-28" version="1">MEFNPFIIVYAAIQFIAFLLVVVGTALDMFRLQSRENFEDRPCITLWGLKPYCNSIVYSLSSDERFSLCPVRRKRFHMAQILAVVSVGVYGTAFALGVIMLYCCLHLRWVCLLLNIVGFVILPIPLALMVLSYKTDENSLCPKLRDDYDFGVGFYIFATAVGMDFIDIVFLLIPWQYDYLDVTCNSKEGNSQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A656</accession>
    <name>A0AC62A656_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amastin-like surface protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2021140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="195" mass="21821" checksum="4422187F17640540" modified="2026-01-28" version="1">MEFNPFIIVYAAIQFIAFLLVLVGTPLDIFRSRQRSIFNETSCVLLWGVKRNCSSIAYAATSDDRWVMCPTRRTHFRVARVFAVITIGVYCAAFVLGFIMLCCYACLRWVCLGLNIVGFVTLATLCALMVVSYETDAYPLCPKLKNDFTLSSGFFLFAAALCLDLVSIAFLFIPWSHENVEGSSSHSKEGNSQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6M7</accession>
    <name>A0AC62A6M7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amastin-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0820160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="XUY37296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="199" mass="22315" checksum="ADF0F2D925183E46" modified="2026-01-28" version="1">MELTLALLLYVIVQFIAFLFVLVGTPIDMFHQRGGGRFENTPCITLWGSKDECHSGNYSMDLEELWRGCPARQHRFRACQAFAIISIFVYGIAAVLGFLQLCCCSFPRWVCLALNVTGAVTLFIVWASMLVVYYQEDFLCVREKDLSVLGSGFALLVIAWLLDALNILFLLLLWPAADPSKSKDPSDSRDPSDSMDAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6N4</accession>
    <name>A0AC62A6N4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0520050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="XUY37440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="916" mass="99016" checksum="428CEB67025D8467" modified="2026-01-28" version="1">MHHDSMAQSPAHRPARLSPPLALFPLRKLTEWSKLIWTTVRGVKKAEYTSDEPATDEARPAPEVVPLRPVSGASDARCETRPVPRPLPIPPPLRMLPPPEERLPCEKRVTPTRAHKRVTWASDVPATDEACPAPEVVPLRPVSGPSDARCGSRRGSRPLCGCKKQRTDRESRLSGALLRLYSRAGLSAAEIRFRVRQRRELGIERFRRVGLCTEESDAGTLQPGDVLPRTDADTASGVASNAATLPPGDVLPRTDADTASGVASNAATLPPGDVLPRTDTATAVGLASAVGQPIPLRPVSGPSGTRCGRSRGSRPLCGCKKQRTDRESRLSGALLRLYSRAGLSAAEIRFRVRQRRELGIERFRRVGLCTEESDAGTLQPGDVLPRTDADTASGVASNAATLPPGDVLPRTDTATAVGLASAVGQPIPLRPVSGPSGTRCGRSRGSRPLCGCKKQRTDREIRLSGVLLGLYSRAGLSAAEIRFRVRQRRELGIERFRRVGLCTEESDAGTLQPGDVLPRTDADTASGVASNAATLPPGDVLPRTDTATAVGLASAVGQPIPLRPVSGPSGTRCGRSRGSRPLCGCKKQRTDRESRLSGALLRLYSRAGLSAAEIRFRVRQRRELGIERFRRVGLCTEESDAATLPPIHCPLSIPQQQALPAVSLWTQEGPQPPIRYPLSTPQQQALPAVSLWTQEGPQPPIRYPLSIPQQQALPAVSLWTQEGPQPPIRYPLSTPQQQALPAVSLWTQEGPQPPIRYPLSTPQQQALPAVSLWTQEGPQPPIRYPLSTPQQQALPAVSLWTQEGPQPPIRYPLSTPQQQALPAVSLWTQEGPQPPIRYPLSTPQQQALPAVSLWTQEGPQPPIRYPLSTPQQQALPAVSLWTQEGPQPAIQHSRWNPFSFTGGDAVRTSTGRAIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RH23</accession>
    <name>A0A088RH23_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_010370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009370">
        <property type="protein sequence ID" value="AIN95138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696680.1">
        <property type="nucleotide sequence ID" value="XM_010698378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RH23"/>
    <dbReference type="GeneID" id="22571766"/>
    <dbReference type="KEGG" id="lpan:LPMP_010370"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_010008100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_010370"/>
    <dbReference type="eggNOG" id="ENOG502RUVD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272269at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058392">
        <property type="entry name" value="DUF8079"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057419">
        <property type="entry name" value="PH-like_2_kinetoplastida"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26290">
        <property type="entry name" value="DUF8079"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25405">
        <property type="entry name" value="PH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH-like" evidence="2">
        <location>
            <begin position="274"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="698"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="699"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="739" mass="80710" checksum="3A17AC69B7591786" modified="2014-11-26" version="1">MCSLETLLCSPADLIAECPVIGPSDVRLVAANFEAILNKCLYCVRLKLPTPLRVLLTIIGDAGELQANKVCLALLQPTEEGTCVDVFCDLAAQLLGRRAAVLRLQFDVEVLFQVMQRFCCAASLKDRLGARLGEVLLGFMRDTDMHADDYRVPRNCCGALISLLRGSRENKNRFGPECATIAACLDASSDFFFQMQCVEVLYRLYKHRSSFLTQAATPAALTSVSSAPANERTASVALHSYLLRGIEGLPNDSTLLHCIHQLLDNYNSDVHPDKIRPFAVLHIDVAGVTVARATTLYFSPLLLVARLPDNSSSSSGGNYLTIPFEHVRSVKLTKDHKLELRLYVIPAKLSHVMSVTQDGMDKLHVSMTRATMRELRTSVVHQWVAERKRTAPRRVVAPVPTDARQREAARAVHTLPAPSSAPPTPPSSSQTSSRIGSTMRPPLTATITERPVNTLQGGDMENQQQPPACGKLHPPQCCEAVQQRQAQHELGGPARMSRSSDYAAADEEAGEQCKRSCLAEVHHAASVKAMRYREEQHEALQHAVDSAKEALEELHRWSARERDQYEARFREDMEVIRRSEAVLKESATDCVQALNTELEDVQALGALLKGEVEKLRERLAKSLGKSEGIEEALLARIKQTVDAQMRSMEETMLSVGLSASSPAGVGSGAIGAVSQYITEHMQAISSGAVVVGTAGARPSTAAAGSAVRSAGRGTRNGRAEKVQHPQQPQPLKERRLDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIJ6</accession>
    <name>A0A088RIJ6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">60S ribosomal protein L23a, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_060560</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703937.1">
        <property type="nucleotide sequence ID" value="XM_010705635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIJ6"/>
    <dbReference type="GeneID" id="22572262"/>
    <dbReference type="KEGG" id="lpan:LPMP_060560"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060011300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_060560"/>
    <dbReference type="eggNOG" id="KOG1751">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1267328at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000035">
        <property type="entry name" value="60S ribosomal protein L23a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_A">
        <property type="entry name" value="Ribosomal_uL23_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001014">
        <property type="entry name" value="Ribosomal_uL23_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011118">
        <property type="entry name" value="PRK14548.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L23A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00050">
        <property type="entry name" value="RIBOSOMAL_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN95615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="157" mass="17477" checksum="012F2374AEA0D3D4" modified="2014-11-26" version="1">MACPTEAVLFSTMAAAPKTAKKAAPKDVKATKVVKVTTRKSYTRPQFRRPHTYRRPAIAKPSNRVTVESKDITAFSVIRYPLTTDKAMKKIEENNTLTFIVDACANKTEIKKAMRKLYQVKAVKVNTLIRPDGLKKAYIRLSAAHDALDTANKIGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJ54</accession>
    <name>A0A088RJ54_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-directed RNA polymerase III subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_091070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN96022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704344.1">
        <property type="nucleotide sequence ID" value="XM_010706042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJ54"/>
    <dbReference type="GeneID" id="22572677"/>
    <dbReference type="KEGG" id="lpan:LPMP_091070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090016200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_091070"/>
    <dbReference type="eggNOG" id="KOG3297">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10256606at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN96022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="295" mass="30690" checksum="2987C52274E38A8A" modified="2014-11-26" version="1">MFSSYILYDTVAIEAVYFPRHFSNECTGSSGAAMTATTRGTSSAATATAAASRNGDDEVYSLTLRDILLHRLTERYVGRIIPSRGLCVAITEVMEYSASYVRGAAASAWLTATFGVCVFAPTPGTRLKARIAYQAAAGVYLTIDLFVAIPFLVPAESLVPGSCFSAAQGFWYLPLDTVDQEGGTHGAELNAEQAMAAVTVGSAKAGNGYGSGSLASSMFSSPAPAAAAPYNAYMVGAEVIVKVESCTVQSEDVLSAAEEADSVGGDGTIHIMELRGSFVGDALGPMSWFEKDDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJ58</accession>
    <name>A0A088RJ58_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_080260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="AIN95835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704157.1">
        <property type="nucleotide sequence ID" value="XM_010705855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJ58"/>
    <dbReference type="GeneID" id="22572488"/>
    <dbReference type="KEGG" id="lpan:LPMP_080260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_080007300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_080260"/>
    <dbReference type="eggNOG" id="ENOG502S47B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275603at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="113" mass="13027" checksum="536BCE39B8CC5774" modified="2014-11-26" version="1">MNSLLMETMVKPLKRYPTLGATVGTGVLCAFTYWWYATSIRSTLLTTQRSCQQMSDRAFHECREMLKAGERSWGGDIRSRDAQVRRLELQNVEQTRSVARLESAMKMCLIQNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJ79</accession>
    <name>A0A088RJ79_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_010750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009370">
        <property type="protein sequence ID" value="AIN95174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696716.1">
        <property type="nucleotide sequence ID" value="XM_010698414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJ79"/>
    <dbReference type="GeneID" id="22571804"/>
    <dbReference type="KEGG" id="lpan:LPMP_010750"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_010011800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_010750"/>
    <dbReference type="eggNOG" id="ENOG502SJUP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265806at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="484" mass="50138" checksum="E36393ED035215E4" modified="2014-11-26" version="1">MWEDAPLIGAVPVLPCRMSAETTTTSTGTARHGSRRRAPTYYYQSPSAVVDGDVRFGEGCVVLPHARICVSRGYRLHVGPFCLFEDFAELVCDGAATTTTDQPRAGDAPAPSAASDHGHAASPLAKAVVTLHIGSHNHLHSYARVHCTVAAATPSPPPLAWQLIGRGNVFHAFAAAVLMALPHPSSSRSTPSAPQLQRFLGDYNVVTTHSAVSLPQGGTSTRDASAPAPLAEPDERGGRLKRLDEHKDAERPLAPADPTEGTAAAAMLQRSVASSALSPSLAALPVESLPGGASVGNRLFRSEEDDAKLSGAHVRTQLPPAASLSTPLSPAVSSNAASSAFQHVIFFSSELRTDGAAGSSSTATSAFGVPRFGARSAAELPVVVQRIAEEANAGPSTTAEVARTAALSVKPQPISSDSPSPGSIGAAPPTAAMLGPYISDVHSDLRSHEEACIVSEVELKCRHYIHQLLDGHGLQPVAARLDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJA0</accession>
    <name>A0A088RJA0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cleavage and polyadenylation specificity factor 30 kDa subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_090720</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN95988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704310.1">
        <property type="nucleotide sequence ID" value="XM_010706008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJA0"/>
    <dbReference type="GeneID" id="22572642"/>
    <dbReference type="KEGG" id="lpan:LPMP_090720"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090012700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_090720"/>
    <dbReference type="eggNOG" id="KOG1040">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1914176at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000017">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor 30 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000051">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor 30 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045348">
        <property type="entry name" value="CPSF4/Yth1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102:SF24">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18345">
        <property type="entry name" value="zf_CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="12">
        <location>
            <begin position="249"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="262"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="304"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIN95988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="346" mass="37051" checksum="D89DD2433F262F52" modified="2014-11-26" version="1">MFVDDAAGTHFDFEDTLPKEQPRTEKKLEICQDFQRGRCRLGDACPQRHIISAYRTVQTKVCKHWLRGACVNGDNCLYLHEYDNRYVPQCAFFERVGECTNPECPFLHTKPNESQPECAAYRRGFCPLGPKCRLRHVKRESACPYYLAGFCPLGPRCPLGHPIQERYDRDAVSKRILAKMIVERADDPTFNRSATCYRAGCFDPGHLAPDCPGPQHSVLHKALGEIQEPGQPTGALESTGRGGGGGSHRRCFLCDQEGHTVKDCPMNTHRNQQRGGGSGGPGAPHNSASSAAMGNRRRLRREGGAGGGGGGGGGGGGSGGGGGGSGGGGGGFGAGGGRRRPGRDHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJF9</accession>
    <name>A0A088RJF9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_090290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN95945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704267.1">
        <property type="nucleotide sequence ID" value="XM_010705965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJF9"/>
    <dbReference type="GeneID" id="22572599"/>
    <dbReference type="KEGG" id="lpan:LPMP_090290"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090007900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_090290"/>
    <dbReference type="eggNOG" id="ENOG502S8DF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273663at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN95945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="238" mass="25244" checksum="9E5583E842B81122" modified="2014-11-26" version="1">MTFVFEARRMPFGSISETYAARLQPIVALHALDELPLWDRCMLVAVLPVVQQRHAASSAAAPQSTVVSSPTLTVDVGNNADAAAATVVVASLPSARTRTASNEEKLRVSPGLAGAPLLEDVALTLTIVRALDELEAVYDSIISIRAEQQQQQPGSGVPAAAAPRRAFAQPKKTSEEILMEQLLQERFSDTTSYLPDSNSDDGENGAEEVVDVAMCFTIKGESLGIGSANVFGGHGYHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJM2</accession>
    <name>A0A088RJM2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_100820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696805.1">
        <property type="nucleotide sequence ID" value="XM_010698503.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22572819"/>
    <dbReference type="KEGG" id="lpan:LPMP_100820"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100014700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_100820"/>
    <dbReference type="eggNOG" id="ENOG502RXM8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273919at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="735"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="780"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="829"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="914"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="962"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="790"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="859"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="986"/>
            <end position="999"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1582" mass="172194" checksum="19D3D3796D107BC2" modified="2014-11-26" version="1">MYPLQRHSGAPARLASCARAPLAPRSHVQPPRQQLPAHRGVDLIQSAYAVLYKVHAHATQLVEEAEAYLTSTYGGTVTAAFKAKAQLYNPTPLKKDNTAAMAAESLLQRCLTMQALLELEGSNAAVSPSAAKDLANALSVLVACLPVDWQTLVVKPENVPAGGVSAAALVAPEVSAATPTQQAPTSTADGSRIAVSSTKRGTSTHAVGSLVTSPTDLVQLALLLRRRWTLQRDLNLLVVALRDICAVVAAGGEAASSGNNLRMSAAEDVPPPLMTVAVTLAMLQLPRMPAMLEVHEERMQVGRLPAGGIADATSAYPHPCPATVLPVWLWRASCATTSQHSEGVKMTAVPATVVVAALASARQITKQVFKWEAHVARYVTAVLAVPSSVSPQGQQPGSARGGVGSPAEASVMSLLHRSDKDFLFDVQVDMSLEHGACNEVQLLWLTAAAAALVAAAGAACGGALAAAGVEKRCSKVERTLRTISPGSAVARALLPGVLLLLGCAAACRRHGPENPASDASSRGLQYWMEAHMLGRQVLGSAHPVAVAVAALLPNSAVAASGERQPSASAPASFTAAHMQAVMPALSNGRNSDMTCLSGKDVSLPLHSQLQQQQRMPAGTLTRLPPLPPVPTSALRPPQHAPLFATSAPLRLEPASSPLASSRPLPALAASHPYLARPPQSPPYPSLSLQSAQTSVITTATAWSSKGDPPPPLGHTFPLPYTPSSTAAAVDGAATQFCRPSPRSSLSALKPPGGRSLRHCHRLQRPEDAFALRSVVKDATLPAGDKDGAPAKKKNTARRLKNSKGSPQSSTAALLLSAISSKSAVTAGTLTSAVSSDSNPRRQLKRDRKFLPAPGPPASPLSAASTSTLPQPKEQPESKQQQQQEGVQEPQQDELYKGAPLDLDATAQGVQVIEPEAEQQDSSRSGGAADTEAIGASASPIPAPVITTDQQCGLVLMSSHSNINLQPKGDGDAPDPHLAQAAGTDTENAEEEEEEEEEETLPERNARFQREIISYYAELNERRAKAALMIQLAWRSSKARQSLHVRRQALYRYVYTIQKAAALAIDGFLSCVLEQRRREAALCARTLADKRRLDQEQKEVAAAQRLTRAMCQWLQRQRERHRLCKELGITHGARLRLYMITAVKVQQWWRRVVVQRAYWRRHNVEMEEKHRLEAEAIRQAHAAVTIQARLRGIQARSRVAQLRETRKAEALELRRCRDSATTVLAIVLQEYAKRQGRRHREALAQEESRAKAAQRITVGWRRTVGRRRLDLAVKRARQLRTSATCIQQVWRRYAAGSQRRYLRQLRHTVQEERLEREARTYEVIRLLQCFGRSAQAQLLVRRLKACQGRTFMENLYLIQAAGRGALTRAEMRRMQVAEQARQRAAAAALEIRRLRATSLVQALLRAHVSRALVQQWRRTILTEKLVVRATAAREMREDTAATVLQRTVRRHQMRQRTAAAEAEAAAALAFLGAMAHRLQQAWRAFAARRERCYRAAAANQCARKRLEWEEVWQLIWQDQFTELDLLCVIERHYIEEQQHVERVRLYSYLCNPDDATNDKCGAETCGAPNADADVLKWAALYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RK53</accession>
    <name>A0A088RK53_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ARP2/3 complex subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_100900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96160.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696813.1">
        <property type="nucleotide sequence ID" value="XM_010698511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RK53"/>
    <dbReference type="GeneID" id="22572827"/>
    <dbReference type="KEGG" id="lpan:LPMP_100900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100015800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_100900"/>
    <dbReference type="eggNOG" id="ENOG502SJMA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="260249at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN96160.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="416" mass="44521" checksum="ADC3CE9B5471FE14" modified="2026-01-28" version="2">MKDATRLPNTSPYPALMAALKLFEGEHNTMGKSCPALSHRLHTFGDCVYELASLPEGKTNESPDEAPSKPPLSHTTAVPLTEAEALRNNSGNEVKSAGTCVPSGEADIVSSAAKNARHIPASTSYPPISIRFVHPIPYAQLDQYHNLVHALSTALHQVAPHCTYGLPSPGHTEATPAAVASLSSVGLCIPTDVTPQERCAAAVFASELSLRALQPVVEGLLQRSCATTQQETLLLLPRTAKTMKAAAPQSVIDSDLMFSSAALFITATPTPVQPASPDTNLSVQTAPPLFYAGTVSLTVCISTDNKGDATLIRRYLKAFAEVEKAPVLLIVRESAEPPPGIGVAAGSALKADHSYVWWCTFVLAPHEMTSAAPLVRALRLARELRPTVLFHVNQERMAMHELLRQKLSAYAAHFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RK54</accession>
    <name>A0A088RK54_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_051130</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase V0D/AC39 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="AIN95554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703876.1">
        <property type="nucleotide sequence ID" value="XM_010705574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RK54"/>
    <dbReference type="GeneID" id="22572191"/>
    <dbReference type="KEGG" id="lpan:LPMP_051130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_050015600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_051130"/>
    <dbReference type="eggNOG" id="KOG2957">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250083at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1690.10:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.50">
        <property type="entry name" value="ATP synthase (C/AC39) subunit, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1690.10">
        <property type="entry name" value="V-type ATP synthase subunit C domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_csu/dsu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016727">
        <property type="entry name" value="ATPase_V0-cplx_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035067">
        <property type="entry name" value="V-type_ATPase_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044911">
        <property type="entry name" value="V-type_ATPase_csu/dsu_dom_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11028">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018497">
        <property type="entry name" value="V-ATP_synth_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="V-type ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR018497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN95554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="357" mass="41675" checksum="A63DC903C2314BC8" modified="2014-11-26" version="1">MGRTMMNYNVHEGHLEAMVHGYRDALLRADEYNHLCQCDNLSDMKSQLQITDYGSFLQQEGTLTSRVIVDRAQEVLLRQFRELRSWAEPPLCQFLDFISCEYMLSNVLKLIVAKRSGRTNFELLTKCHPLGVFPEMPTLIAASDVQEMFEVVLIDSPVGRFFSADGGFERDLDELSVEYIRGILMKNYYEQFYDFCYNLGGETREVMCPLLDAEADRMVLTFTLNTLGMREITPVDRRKVFPNIGSLVDIHDDIAESENEEQLRDRLRRFTKYFELLDESSRAMGSASKKSLERRFVEQLVVMYNDAMTRQFQYGVFYAYVKLKELEINNLQWIADCVVQQMRNRLHEYVSTVPYAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLG0</accession>
    <name>A0A088RLG0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_150240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697401.1">
        <property type="nucleotide sequence ID" value="XM_010699099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLG0"/>
    <dbReference type="GeneID" id="22573440"/>
    <dbReference type="KEGG" id="lpan:LPMP_150240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150007400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_150240"/>
    <dbReference type="eggNOG" id="KOG0374">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268868at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000104">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF396">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="2">
        <location>
            <begin position="169"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="374" mass="42470" checksum="F1950AEF39B68E02" modified="2014-11-26" version="1">MSHTKRGRCAVDLSICTLSSIPTDTLSVERENDVLYRLLELLPERYTSNVLKEQRIPEELIVQILVKARAIIASEPILVEVDSPVYVCGDLHGQYHDLVNIFKRCPPLGGTVFGADAKKARKETNPSMDDNTYSFLLLGDYVDRGARSVEVVVTLLALKIISPRHMTMLRGNHEDEQIMLLYGFYDECKRRYGIKLFKMFADFFRILPVAALINGSIFCVHGGLSAELRFLRDIPDMRPCNVPHSGIICDLLWADPEADLPAGVDWAPSSRRISYVFSERALERFLVENDIDLVCRAHQVVEEGFQFFPDHKKRHLLTIFSATNYCNEFGNRGGILCVDEKGVCSIITLEPPNFVQQRDIMLFRDPLPNPLNHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLQ8</accession>
    <name>A0A088RLQ8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_161220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN96997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697650.1">
        <property type="nucleotide sequence ID" value="XM_010699348.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22573701"/>
    <dbReference type="KEGG" id="lpan:LPMP_161220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160017500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_161220"/>
    <dbReference type="eggNOG" id="ENOG502S0K1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="247450at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="918"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1098"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1440"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1547"/>
            <end position="1576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="940"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1443"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1547"/>
            <end position="1556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1846" mass="198179" checksum="26314F742BFEBE36" modified="2014-11-26" version="1">MQPSITPPLPPIHVKLGEAASSARTPSLPSPWLSQVLSLSSDYEIHNEQLPWGAHDGTGAGVTLASNYSETVKGVRRPQNECTSALPLADATTEMRSTPTLGSLAQASSSTSRSDSPSWRRVETPTATPPSPTAMLGLNRSFFSQKTRAALASSAAAAAVAPLRTHALTARMPSQSHTQRTVAAPAAALSLKTLLSLRRDSAGARTSVLATARHRRLLPLTSAERSAHKEERDGIVTQTRCLTRESVLKSTSHSSESKENVRGSASTLGRTLCKGHYHPSSQAQVALSSPLFFNATAATATILGHGAVTGTPIRIAGQHSNGSRLSDTASPSDEGEITLASLTSLQQRLCGWTRGTHVAVAPTTGHGVNMPEPRRGHGRQARSTTAPFVSTTELAGYTATSPRSVKARTVGITTGHTALAVSVAQWKPLLDSERICGERGKHVARLLIERLLGITTTAGPFGGHSTGGGVLDHFSPDMLDEGEGGGGGARGGHLRPLCERAVVAAYLLSSLLDGLPRHQQSLSPYIHMLLDFTFVSDTPTNRAMLGGSVQDDELLYALEVVQEDGGGDDGGTAAAAAWLPPDVAGRGSTSWPSIELHHGSRSSCLTGNGHSDAKGLYELLYPCFTRMTYVAAHYDAARTTVALAYDVRSRELHQRSVPRLLECMHRHWMRWLMRAVLRAWECLCQERRVQEQRQRTRWAQRWTSERGRIALRRWRGYAALTLQIAEADSLAKSLLAVKRSGIERLENESAAMQASSALLQRTLHRQDEERDAMEGRIVQREQAYKQLLQQVREMDRVGSLMLRSLLLSDAPPVPNEADALNGLSAAVSSASGVGDQQSSTLSLSVSPDGLARSAATSSFCEASGDPIVRHPPHTLVALPTLLRWAKACVATVQAEYVSFFPDEEEEESGDDVIEAAIEGNAKDLTTSRTPEEKIGPRGKSTTSPSPCTPSLAGGSNTNKTEATRGPSTGLEVLLTPTTAEGSAPTTRSIAASDTVLVPLHMILLLMRACSGAQDRSAMVGRDGYNVHITTTTTSVTITSAEDTSLTDNGDATTPAGPSWDLVRTIELTDRVVLDECRALLRKEEEVLASIDDGRSTAAATAAASASHGERRPPTPSKSGGTSNALASVSVSGVSIMHRLTSATRENLLQVCRVVVDTYEQLTNTACVVTAEQLFRRSRGTLLVFIAALMRYYTNWTTNRRQQLTPLSIKGKWTDLPVLTAAAHEGTKHNLYEEWSHPPHSHRGWLAHVQRQAQWIALSFSALHDAIRVATCSVDALSIIEQERVAGLLQRISLTEFIDLLGHSPEHTMQSYVDVIGVVERYAPSLHLLFHQYALPLAQLRADVEGANNAPTQSRNAQNDDDGGGDAYITGNTVWGLLCLTGLAGNAPRLSGASSKRGASSVSMSLAIPSPPLSATLHRPAVFSLIEQVTQGAVAPTAVQRQLSSMPGGSGPTASPAPGGPPFGSPDRTFFSRRTRRADVTSVSCKGRPIPCYARVLRDDHHVDLRADTGAVCVNYVQFVKLVIRLAHAWQCQQQQQPLIAEEEALDRAKAGEDGSRRVTGSLKDAPSDSPLSGAAPSSCSSSAAFTTASCTSSQQQQRRTSASSDHVQYEAVDYASQLCLPYLNTFLGGLLLPRLLGANRWIVAAQRAFWCKPVLQLLAQHHDALLTVFNMYQRPCESRGVRAALPPPFSTALATYSGRGSTATGTGPALGKESDELPIESHFSQRRLPRSIRSHSGSISSAKGNTSAVPATLRDVGIVSVLRWNDVQAMAKELEWHREARLSEMGVRHCFDRVVADGAREGAVLFFAEFLHLLCAVATYAAPDPAVPLEIKLDLFLQTRVLVQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLR2</accession>
    <name>A0A088RLR2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_100550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696777.1">
        <property type="nucleotide sequence ID" value="XM_010698475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLR2"/>
    <dbReference type="GeneID" id="22572791"/>
    <dbReference type="KEGG" id="lpan:LPMP_100550"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100011700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_100550"/>
    <dbReference type="eggNOG" id="ENOG502SFZG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="262579at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="267" mass="29563" checksum="6316492C59290F92" modified="2014-11-26" version="1">MPSLVKPSQKGRGKKKGGKKPAKIVPDPDAAYRQQLDETVYIPKVARKKVLDTYRAAADRAIMANTVDVSSPQRDGHREDPISLIKVPGIFQSLGLCLTDDQIDQITAMIAQDPQCLSQENDTVYQMEPIQGLGNFADREKLHALLVELLHTRVLAYDPQVLACPHPRFTDRVSSVVCRATEGDIRSCFNTIWEASGRMVMVTANGTCTRCVAVEQLEGLLTNAQTESAATQSLTPKEFRDLCFFVKGVNDDVVKEDAFLNCFIHVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLY4</accession>
    <name>A0A088RLY4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">MGT1 magnesium transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">MGT1</name>
        <name evidence="13" type="ORF">LPMP_151230</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697498.1">
        <property type="nucleotide sequence ID" value="XM_010699196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLY4"/>
    <dbReference type="GeneID" id="22573543"/>
    <dbReference type="KEGG" id="lpan:LPMP_151230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150017700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_151230"/>
    <dbReference type="eggNOG" id="ENOG502R8TN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="165352at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12832">
        <property type="entry name" value="TmCorA-like_u3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000001">
        <property type="entry name" value="Magnesium transport protein CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494:SF1">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="764"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="800"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="118"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="232"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIN96845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="824" mass="91653" checksum="7D6287D181A22E3A" modified="2014-11-26" version="1">MSSNASDTVAPASLPAEGVTMTPSDQPVHPGTPNLHTPHSAQRPSTSSELGSNRVPPLPCAQDSATVAMPISSTEVRLSSSHSYTLRPLEIVESIKVLHELHQNGGLTKEEFAHAKQQILDSGSSSASTFKSKPKRSREWRPRGRHHRRRGRNSHSLSTSTGTHPSQDSRTCISSGAGTKSTSHRPSRSSSSSSSSSDRFIIVPRSTVWRTLNDAIEEGLLVHHSAEGHTVRSECNSASPRVYSPLLSSSGGTDVGRGGSEKEKQGESCAGAHRRNGYQEIPSEDPLPSNVGSGAAVPTPALAAAPGTKDGVFVSLGSGSVGSATAATGSSVARHIASDGRDKAKYGAFLSRDDGARVVGPAPAMRTALRREDVVRIHYFNSRGGSGNHFSNVELQTSQLRDPIFVHKGQSQVIPAKLRASVSRPGHDEPTMVAMPAQDSQIFQLAEMTLEERRAWEMTTTRSSSTSRRARSSYFEQSFNWYWVDVTGRDPSRQRYNATLRYLTDRFKLCESFLVEREHTLVLPQVCESPIYPGQYLLNLRVATDKISISDDSVMELTNRWIIVVDLKQHVVITLHRVDTHGMANLRAQWKRVIENNNVSFQEFLLKIIDDAIYTYQLSLDVHTALLEKCEAKLFVEKQSVSTPAVSDHYIDKRILRHFAGSSRSPFLHRLLDEKDHSPMTKGEMNSFLHHLHRRTSVQHRMLNVTQIVLAKAFTKLRLCSREMAEQMCSSCIEISDRAMEVRDDAKTLLNLHISLQSFRTTELMAVLTRVTMLFTPVTFLAGVYGMNFQKRFPELTWEYGYPFFWLMCIILVIIMHTFFVREH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RM16</accession>
    <name>A0A088RM16_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4110 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_160090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN96885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697538.1">
        <property type="nucleotide sequence ID" value="XM_010699236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RM16"/>
    <dbReference type="GeneID" id="22573586"/>
    <dbReference type="KEGG" id="lpan:LPMP_160090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000010700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_160090"/>
    <dbReference type="eggNOG" id="KOG1230">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4447at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025183">
        <property type="entry name" value="DUF4110"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052588">
        <property type="entry name" value="Kelch_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46063">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46063:SF1">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13422">
        <property type="entry name" value="DUF4110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4110" evidence="2">
        <location>
            <begin position="618"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="707"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="731" mass="82498" checksum="E2E572D2D91384E2" modified="2014-11-26" version="1">MGKGRDKRKKNEDSAKAAKRATRQALKLHKGEKKENGEEATEGFNNEEAIEVTLKRIQKQERKVRAVEEVANVDPPTPRVNVVLVSHPERDNELILFGGEFWNGEKTEAYNDTYFFNAKRNTWARLSSAVKPPPRSSSQGVIYKQYLILFGGEFVSQSQSQYLHFKDVWRFDSRCSEWEELKNLKGGPSSRSGHRMVLWKRNAVMFGGFYDNALECRYFDDLWILSSLDGAGCWSQVKTAPMTDLPHARSGHSMGVYHDELFVYGGYSTQKFNRFKKSEATVHHDLWMISLQQEKEHTLSEGLLPVWTKIKLGGIPPPIRCGVSCAFKDKRLYLFGGVVDIESPGGKMMSTFYNDLYVFHMDTKRFYPVVLRRVAKRVAASGKRDHLDDLAAQLSALDLCHDKPSLDSETDSSSDESDDELPSQPGAAAASQDLKESYETNRHGQILPHRRIDSAMVVIGYTLYLYGGQFESSKKEITMSDLFALNLNKLDTYQPLLSQDLSAALWLGKESESNTASWESGSTVASAVYDLDYDEDDEDNEGGADNMGRRGVHFGNMSREPVPNSEDDGDEAPEAIPAELAMRVTPSVEGVADAIAGITRTGKKGLRVHKAQLLAQLGASAAVPTPQTEETFAAFFARTSSFWLNTARESVEGKCTDRHLKKEAAEFAKQRFYEARELLAQLQLVEDCEKEEAKFFRERRLQKEKEWEEYEEAQRRVEQCPSHGNDEADKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMY4</accession>
    <name>A0A088RMY4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_180970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697931.1">
        <property type="nucleotide sequence ID" value="XM_010699629.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22573987"/>
    <dbReference type="KEGG" id="lpan:LPMP_180970"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180012600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_180970"/>
    <dbReference type="eggNOG" id="ENOG502S4GG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266146at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="694"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="753"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1086"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1337"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1418"/>
            <end position="1564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1792"/>
            <end position="1825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="773"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="805"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1086"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1098"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1128"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1482"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1516"/>
            <end position="1531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1548"/>
            <end position="1564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1802"/>
            <end position="1812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1825" mass="194621" checksum="EC6B8D4A162FCA9C" modified="2014-11-26" version="1">MSCSASKSTSTKRTGFRISKRARDSFTTTTGTSAPQETSGSRRHPHRCSVATSGEKLAPQPQNVWGARAASATTAVAPEDVQAVYATFAAGGRSPDSRRSPSAGQSSSAPMAAAKENSSAMSLPLPLSTGILASSSCLVTSRETGGPSPGSPRASSTYDAHGDMAQLYLSPITASLCATSHHAVFTGPHFSGRSASWRSGTAVDAAVSSAHRHARDSSGADSGTVDTDGSSSYRASQSQANALMDTWVHSPLRVAQQRGAETRPRPSFASEPTVGASKGFGAPGGVNYAGLARRSPASSGSSTHFPPVSTQHMPVLVVPSVKSVSAARELLTPLPLVHPQRRSLLAAKDGQRGGWTLSSSWAPAGSPVSFSARSPSITSTSRPSSRSDCNSSIARSDGSRRAVAFQLSETIQEKGTITTTPKRQPEKSGEDNASPQNRQRFGLRHCSPSMSICSLSIGSAAASIMDEVPPPPPPPPTQLPLGRGIKTRGGGSLLLPPRESVPLSRLPHHLDSLGSSIFNASTASGCRSSFASSTLWESTGRMKSFMLSPVKSPLRSPSGNLSIPSETIAGTSRNGIISSEANELPSYSDARQSGAASQAQLFHYPSSVISLQTSLVSVPNTVNPDDVEEDMVGLRQAVVPLPLLTNHPPATALVVASVASSSVENDKHEAGVDELADARPLAIAIISDAIGKPAQSSELSTPQLSPSSVGGKTTQSVDKLKSNEDLNSKPRSGGAFGNTKAQLTTTFVQGPSLVSTEVPSHGRLSKAQALSPRQEELARSFRDRIQVGVRAPRRQRTAQRVSSASRDRYRASNDTSHGSRAEGRGNTRRRESRLRHVKGQTAQQPAAALPFIAVAAAAVAYAKLLRPVHALRLRRRFDEVIAPVAAYRIQCKWRRYLQLRRVEQKMAVQLLVAWMRFRLQLLRRAKDASARLLQRVFRGELVRSLHRYLYEQMKRNRALDVIRYYVQRWEAQKLYRVLQMQRDERALVVNQCVQGNMQLCRAEQVEWNAIVQDGAEILQSRPCVSTQDWVEGVAALTGIVLDPRASNFIRSSVANSAASTRARPTTMAQLRECLAAFARLEHQLFRSSDTKEDKTASSRKGSAPSSAAPSPPLQPTLALAMRATKSTQGERKDGFAKAHDDAHNPSYTAMSIASDGAPDSPTPSNPTATDDDFFAAYVQLLCRVEATERVELERRLLGEHHELLRKQLLLDKAILYATSMRVAPLFSPLLLDMPSEAVLIQAVRLFKEEREARCAIIQLYESMPLACLRRPMLNPVAKVRYSDLVRLSNGVDDPWEDAGRSEQRFYRETVAYKCLASSMSKLESSCALSYTPRPSLAPLGADDPDSVPSSRLMSPSHEATHNGGGGHLSIPVVPPLLSVQRQASYGTLSGLRVRMRVTAPLPLHVTSLFPSPKLAESVAPGGGGVTRMNENGHHANSFRASSHHGRGDVQSKTAIPSPHRRPRGPPLPLLRKLLRHSGCARSGTSRPSFQSPPVITNPALNSREGASESRPPCLNTYPNPTHFQLTTIRNPSTEEEGCGTEVGVEGSAQRSTNASSTNAACGSNANQDNCSSNIISRDADAGVVLQLPSPASAARQRFTAAAHATAAAASHFSSPCKSSTRVSVTVSSYSKGNVTEGLTASDEESAALLDRADLVDRILTTQPVGETGSGSIFSAAKVVPRLTVWHATAAPLESLAPSSMLPEMPLCLCQQIRTSMPMRFDKDASDAAALLSIPPPVLFSPAGVSAFQMSTTTEAAAQASTSLGSCRVKAVDFPPSPTLSSSVLTVAKTGADGWSRTALAPQPRPPPTPPPRRCYAAPHIGEASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMZ0</accession>
    <name>A0A088RMZ0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vacuolar protein sorting complex subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_181070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97288.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697941.1">
        <property type="nucleotide sequence ID" value="XM_010699639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMZ0"/>
    <dbReference type="GeneID" id="22573997"/>
    <dbReference type="KEGG" id="lpan:LPMP_181070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180014000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_181070"/>
    <dbReference type="eggNOG" id="KOG2280">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1792at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.780:FF:000005">
        <property type="entry name" value="Vacuolar protein sorting complex subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.780">
        <property type="entry name" value="Vps16, C-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016534">
        <property type="entry name" value="VPS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006925">
        <property type="entry name" value="Vps16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038132">
        <property type="entry name" value="Vps16_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006926">
        <property type="entry name" value="Vps16_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04840">
        <property type="entry name" value="Vps16_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04841">
        <property type="entry name" value="Vps16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007949">
        <property type="entry name" value="VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97288.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="924" mass="102952" checksum="4F05B4D5DBD805B2" modified="2026-01-28" version="2">MPHRRHFDRTSRLGSWISLGTEALFRFAELEDYSNTLPFKFDNSLMAHSGYGGLVALFSPRACNFSTNENSIFLFHLAGTPLQKRPRIQLKAIERVIYMTWNKAADHLIVVLNTGFVHFYNYCGAAAAPSLPMEIPIACTSCDNGFVALVDTATEAKLVLVHLGRQKEYTIRELSLPQSIRQFMTTIALVALESVDKEETKEVFLSYTPWSSNSFICRCLFGASNSSFLELAVPVEGGRVLGMCRSPTSRAVAFMMLDGSLYSTSSGFSEVSLLRHTDVTLESFLQMTWCGGHCVAYLQRIQYGGALDEGEDCPCSLFLMNVDEPDNNDCISDLPFDACLLPEKDGAWVVSREKLFFLQVAPLAVQRVFSVASRAAGAMLVATYDEFMTGDASAVRMLRNLERASGALVEAVAECVAAAGFEFDAAQQKRLLRIAAFGRTFCSLCDSSAFVAMSKRLRVRNHLRLEPLGMIVTDQQLTDLGEARLLQRLTMCNEHQVAFCVAEAIGSDVKLVMLDWAMCRLARVSVHNKDEEREVAKQIVKKLKACSFTSFAELAQQAKVAGRGTAAVVLLDAEVNPSQQVTMLLSIGEPDMALKRAIHAADADLVFTVMVHMIRNRGSTALASLTAHKTTCDLLLQYVGVCEGSQQLMAECFNKHPRVQAYFHLCSYFREEARLGHALSQSMESGSWEMLQECKGVDIQAAIVSTKRAVEHSPRSQPTTTAFSPIVGSGIPYPLSMIEERFLQLQNNLLEEQTQLMNEYKDYRFLQGSAADTIRYAFEHGRTSVAQRLKTAFCVPEKMFQRCMLSAYLCTGQWELIDDMSGISSSKKTLLDGEAFVTALLSYKRPQQAKQYISRIPKIETRMEYYVLCSDWFGAAADCKRHNDPDLLTQLKDRAKGNPDVLRQIEEGWCTLTQTTGISFPKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RN31</accession>
    <name>A0A088RN31_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Qb-SNARE protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_190010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697996.1">
        <property type="nucleotide sequence ID" value="XM_010699694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RN31"/>
    <dbReference type="GeneID" id="22574055"/>
    <dbReference type="KEGG" id="lpan:LPMP_190010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190008100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_190010"/>
    <dbReference type="eggNOG" id="ENOG502QWNJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd15841">
        <property type="entry name" value="SNARE_Qc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="9">
        <location>
            <begin position="227"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="187"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="83"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN97343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="322" mass="36815" checksum="D06666F5754685A4" modified="2014-11-26" version="1">MEYIPNTDGLMRSTLRDTIRRLHRVRAKAGASDERENQESSGDPFQDLTNAFIQAATRTKNNINERNEGCRQHGQDHMAIQQSNEIRKDLRQMEGTLVELRKLVDEAEHRLAKENRKKKPKASKVQLLERNYEGRRSQYDNCVTALQNLQNMDAQRIEVDKGQINTAEEMQLGKRAQLRQQLLGMRRKDNGNGETLGPGDVELVDNTTGGGRLQDNETTKEQMQTIAAHDAKIEAGLSRLKEGVGRLHDLAIQIGAQIDIQNEMLDKSEQTMDKNTQQLRAVERRLKKFIKETRPMNCFLYLCCVTLIIALVGFFLVQFQVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RN55</accession>
    <name>A0A088RN55_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_190310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698026.1">
        <property type="nucleotide sequence ID" value="XM_010699724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RN55"/>
    <dbReference type="GeneID" id="22574085"/>
    <dbReference type="KEGG" id="lpan:LPMP_190310"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190011400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_190310"/>
    <dbReference type="eggNOG" id="KOG1524">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="408728at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000007">
        <property type="entry name" value="Intraflagellar transport 80 homolog (Chlamydomonas)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056456">
        <property type="entry name" value="Beta-prop_IFT80_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056157">
        <property type="entry name" value="TPR_IFT80_172_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24098">
        <property type="entry name" value="OUTER SEGMENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24098:SF0">
        <property type="entry name" value="OUTER SEGMENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23335">
        <property type="entry name" value="Beta-prop_IFT80_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23387">
        <property type="entry name" value="TPR_IFT80_172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="7"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="IFT80 second beta-propeller" evidence="2">
        <location>
            <begin position="123"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="IFT80/172/WDR35 TPR" evidence="3">
        <location>
            <begin position="440"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN97373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="594" mass="66583" checksum="1C2429D736E03D78" modified="2014-11-26" version="1">MKKQIKWKAHKGVVLCADWSRMSGMIVTGGEDGVYKVWDPHGCSIFVSAAGEHPITSVRFAADGESFAVGSFMNVRVCDKTGWSHSYERTTEGSAMALDWMPDGTQMILGNGTGALSIAQIVDRKVSWGPYSVTLLDSRRLTVQDVVKDTVQEIELADKVIKVELGCGYLVVCTTTQCCCYSMDRLNAPVQFDLRDPVISIILGLRQFLLADCSQGLQVFSYEGRQISVLRLQVALKPDIMTINLLSLSPDTVAMRDPADASHILFFDVSSGKLFDDASVAHHLDIVSVHLSQSGSLHDRKIAFIDRNNDLYFGPVHTKLGFHKLSTMTTSVSWHDAHETLVAIADGHFATWYYPSTIFTDRDLLSLTKTVRDDGHAEFTRNDRITHFHHTRVLVRRGGDGALLTLPVSPYPVMIFQLVTQKNNWEGATRLARFLKDQLLWAVLTALALRAGELNVAEIGYGALSDLAKVRYIHYIKGIPTPEARQAELALLQHRPAEAERILLQAGLVYRCIDMCTRLFRWERALEIAKERKTHLDTVLGRRERYLQEVSQKETLAPFKDLSGKVKIDWAVIEEKVKQEAAKELERPNARPYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNF7</accession>
    <name>A0A088RNF7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ecotin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ISP2-1</name>
        <name evidence="2" type="ORF">LPMP_150350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697412.1">
        <property type="nucleotide sequence ID" value="XM_010699110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNF7"/>
    <dbReference type="GeneID" id="22573451"/>
    <dbReference type="KEGG" id="lpan:LPMP_150350"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150008500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_150350"/>
    <dbReference type="eggNOG" id="ENOG502SMRH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273894at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="610" mass="63784" checksum="92883B2686016E1A" modified="2014-11-26" version="1">MLRAEARIGLGSHDVRRTLIKEELRPLAPPCVACGSGASYDPTASPLATGSAQSRSMAASAGADGDIADIPSAWLEGNFHLKPAIDDEGEAVAASTGAAPLPPASSSVLRTYQALCTAAEEVDYDLLYEEGLRQVEERDVETGLATTWRTRRCPSVSLLFSSMTMTASAGSSEARGERPLLACGAAALHDLYTKPPSWPFATGRGATGRLSAALLASRPASQASIMSAATSSAITTTTTTSKVKAPVSRSNGSRGSIGTLSSLSAEATAVVRSYAATFTEALRQVVQAQRHYSSGVGGDPPRLGSTSGARLGKNDKEGSNSPAVHEWRTHMTAALMLAICSSCHAWFERTLQQPRRPPPSEGVQQRAAGDADNAPRCCCPRCGHDVDAETGGDTPTTAAAWSGPRWVWPPSVSTADFDAVARDSTGTSTRAIDSAVVRCLQEPFAPAMATRQHSSSGTGGEPCGTNGVGFAEAGDGDEEKPFAALVRHSRASKLRARKEKRRDTMGTSAAEAHTHQAPWSLASMTPFRPSAEWASTTVSEGGSIARGCTETGMSGKTMTFPVAAPPSESPPLSELAVPPRENLLAQSLRGALSCLYFHELWANAMGEQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNI0</accession>
    <name>A0A088RNI0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_150670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697442.1">
        <property type="nucleotide sequence ID" value="XM_010699140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNI0"/>
    <dbReference type="GeneID" id="22573487"/>
    <dbReference type="KEGG" id="lpan:LPMP_150670"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150011100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_150670"/>
    <dbReference type="eggNOG" id="ENOG502RZCZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273700at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056:SF2">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="830"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="831"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1022" mass="109402" checksum="EB56444FD15EEE52" modified="2014-11-26" version="1">MVRTREKKPKGDSAFAIRRQKVGRKKLAPATATRAEVHARTLRLATSTAMSAAMAAPCVKDPAAHPASSEMTSAGMRNSESKHKRPIIAVQSFSELLSATRHYKPAQRASAFATLTRLLRIQREKDCAAAAAAAARSGGYAAAAADAKSNVFEEYMRCAAAAERVPSPTDASPTRLSGLSPLERLKSFAAALEAVTDTDDDVRREALQSLQVLVDYQWISCKRDGSFAPTPSSSLGPNPTHEAADLQRCNALLLNRQDGDGGRCSSAAVPGGVLESTSVDRVQAVLQAVHVALTHALKPVRVSGVELLSLLLQVAPPSLVRAAARAVCKHQTSYYYTSPVMVGSELTMGASASPAATATSAAGTATAAALEAAQARAATLLEEEELWMLTLVRRVSSLVLRTKHMAVLPVLLSVFLGEGVSRAVGASAEDSLTAELLHTHPLLCSGVESRVVRASDVSDAADGNGGALWRYPELVNSFFDDVAPQWGNHWKELMELRLELLRQEDKLAMASALARSFATVLVFFKRQQQLEQQYLGSSSRRSGYVNFFSRSRVHYIKALFIEKMPVTMHELLLMSSAGVSATPSATARATAAVATAPSSKAMKARLELALALVMVCVPLTGTEEGWRLIRDYFSIVFSLPCATSTPPEPFRFPSVALLEMSVRLFAQVMRLYPCVAPHLHVAGEDHGSAKRDRGDATSLSVSSQSTPVFHQQSNVAERLLTFFPALLTTIIKHLVPRTDPPSAGVGDTASDDIAVVRVLLCAATILERFAVLPEDLLRCGGASARRKGSGGTTNKSDSSAATIAQRLEEGFSLVPRLLFALREQWQRRQRRPEAVKRVRAENKNDNDSRLGDAPAQTGDSTTMPAVSRTGVLLAYNGIVDLVVHRLLRVLWFLGSSGHPLLHAQHTISTGKAASSPASAFVWTPAPLAALLTKSITFLFGSSGVAGVLQRCSTPTVLLAHSTLFYLGGGGRTSSPIARMGAVDAICVTAADTERTPMDEAAERWTDMLDVMGTLRARVHVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNQ3</accession>
    <name>A0A088RNQ3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_160080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN96884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697537.1">
        <property type="nucleotide sequence ID" value="XM_010699235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNQ3"/>
    <dbReference type="GeneID" id="22573585"/>
    <dbReference type="KEGG" id="lpan:LPMP_160080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160005700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_160080"/>
    <dbReference type="eggNOG" id="ENOG502SJ99">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="260743at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN96884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="392" mass="43796" checksum="507A12F16B1592BA" modified="2014-11-26" version="1">MTQKAAPSSSLKVPHRMPLQHTEWGAVLRQLVELEERAQKRLETVNVEIQYLETVRGLVMSERRSEPSARRRSVAVLFRRNDGKRDRDEVPFVGYLSECRTQRGEAATRSFTPFRQAGLFMSINNPAVRVAPLSLSADEKERQEVEYMFPSCPPIGVVKAKHFPLATAARLLESLTAAGLDERDFALSGTSARRCLSIHTSPEPSDVEALCATVPEELVRALCRDSMGDCGAIASSLYTKLAEQATLRALVLPEMRVHSVKLLRLPPSRQQLLLDTTMWTLRQCCDCCDRDLMENLHVQWCRVLQSTAPASRARTVLQRKAYATAYSQLFQRLSAASSVRQGYLVLVLAVCGDFLDLVEAGKLPLQRPHDYFVFRGTLATSRGGQPSPRRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNY4</accession>
    <name>A0A088RNY4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">OsmC-like peroxiredoxin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_201390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698340.1">
        <property type="nucleotide sequence ID" value="XM_010700038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNY4"/>
    <dbReference type="GeneID" id="22574348"/>
    <dbReference type="KEGG" id="lpan:LPMP_201390"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200019100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201390"/>
    <dbReference type="eggNOG" id="ENOG502S2IH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265231at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="OsmC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="346"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="360" mass="39520" checksum="3F42396E6B759EFA" modified="2014-11-26" version="1">MYRRTRMHYGVLAVFVKELKKVPAYLSYKAREGARTYVDSASKAVAFLKGEDLNEDPVMRSKRRQHRDMYQAILREQAVKAQEDAAQRRASLSWKEKLQLSFKEAKESVAQMTSAKAGAMALLQHCTASHAAEVALEQGIDVKNVQVVFEKVAANNSVGYEEVVVGYIDAPVASKEEVMAFAEKLHKACPVARSMHIEWRQGSADVREQGNESFLRGDGRRREMEQVTRGVERAENHTGSSPSDFSSTADSASIVHAENIPAGIPGSRRTYASMSSWASRGGGSGDLRDDEGELHFPSLKRRDAARNYTCHDRSDIKEPSKETCTASRPPPPPLESEPSAAIQPASMNSGTASSSSSPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPA2</accession>
    <name>A0A088RPA2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleoside triphosphate hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_204330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698634.1">
        <property type="nucleotide sequence ID" value="XM_010700332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPA2"/>
    <dbReference type="GeneID" id="22574644"/>
    <dbReference type="KEGG" id="lpan:LPMP_204330"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200049500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_204330"/>
    <dbReference type="eggNOG" id="ENOG502QVF2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002737">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase complex I subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="556" mass="61227" checksum="510F484C2C4EC7AE" modified="2014-11-26" version="1">MRRLTRLVTGTAARNVTTGETISDRFASGAERASEESHPLLYQVPVFASRTVGREAEVRTLWQNLLCGRHYQVLVGLDGIGKSTIAAEFCDTVKHSQRFSCIQWFNGKHALQSQLQHFFASMKGRKEKDVLLVVDDVASPEEVLALIPEHASVYVLMTTSAANVMSSTKIACLSTSALSPQASRQFLSELTFSQELETVFYNLGYVPLLMHIASLLMKGDVCSAPQLGRLLMEKSVRRDDALSISAALSMLVDIGIAELEKTYPNARAMLRIISCFHVSDVSDAVVGAIVGNAAGDFSVTASQLGILSPKWEEGAFALHPLVAKVLREPLEAHVVAKAADALLSLWPHRWRGMGNRFAYNLVWHTYTVAQHFAACGATLMPAIVTSMDRSATFLAHVEVRDLAVAAQLWMQVYEQDVSRKEAPSPDSVRMLRECGRLLHFLKDPRAEEVLQHAWKDCVVVHGKSSAESALILGCLAPYLPATNANLSLVEEAVAVLEGRLVSVDLVLAREEVRMVWQTIFVLLMCKGQYMTEMHLAIPEDLMRALERADGEAAKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPB0</accession>
    <name>A0A088RPB0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exportin-1/Importin-beta-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_204440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698644.1">
        <property type="nucleotide sequence ID" value="XM_010700342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPB0"/>
    <dbReference type="GeneID" id="22574655"/>
    <dbReference type="KEGG" id="lpan:LPMP_204440"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200051100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_204440"/>
    <dbReference type="eggNOG" id="ENOG502S0G5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271367at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="946" mass="101823" checksum="FDBD4573697273CD" modified="2014-11-26" version="1">MMSSHEVNVAAAVAAVVHFTTHRDTASNQELMHAIDHSLDAGGTPAAYTLAPQLLQWALGDAAARASPGIIIFVSVLNRHFCVQVILERLAQPLDRRPVKLEELLQLYVVALRSLSMEAARRQLTQCVACLLILLEDHLIERLHGWIRGGDATSADECRMALHIFVAVVDLLADRRVAIGSVRRATQRRQLQEHLAIALESPLTDEADLPLLVRVTDAAVRFLSEAMYGEPQEVAATFWEALPTSTVWQYCLRCLGAAVAESSPPARCPEEVLSVVCSVLRCQTIVNTAAEALLSSALTLVVQPISPSSATTMGWETISRVIAAALEASTMAIVTQQPSDVPLFRLFSSAADRLAQLLQAPAAPTPAVCHVCEGISALTQALMPAPLPEMDPDDYPDDFAEFVEETHAANAEKLAAVVQLRPFLHGCMRALATRLTHSGFAQEEWRSIAAYVARQVTDSNAEDYEAAHDDVQLAVFTTYERLTALLGTLGAEEIKTAAPELGQQLVLVMGNSSLVLNWLDSTRPADLLVQSALLPCCVARHVSSTSGAGWVMECAAVRVMDLLMHALATYQENGEHCSSDCATAVMDVARATAAVVLAIAGRLGPDGVARLRDRSTPLVSTLWQCVVSAAGGPPSASTQRAATDELAKLLEAKLAALPDSAVELLKHQDAYTQTVLFTTGGVSNPSLNTLEALAHTLHCVAQLSAEEAETVETWVCYGVVERLRSNCEAGEWAGEALVTLLDSWNAQHPHLLVHFLFLAVAVPAEMQSSLLLAGIARFFSLPHSQDTSTRDLAAALEVRFVHPIAASPATAPSLHALVLWLLQPHASFTASDGARRVRTLAECGRALCEGGHVPALSLTETLVTCVARWQEHKFASSLGCGEADEACEDNGTNCDAQLNQKVLKQLAMWSRCVSVVSELSASAPPWLTRLQSAHDDYERMEVLKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPI5</accession>
    <name>A0A088RPI5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_205200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN98012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698719.1">
        <property type="nucleotide sequence ID" value="XM_010700417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPI5"/>
    <dbReference type="GeneID" id="22574732"/>
    <dbReference type="KEGG" id="lpan:LPMP_205200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200058700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_205200"/>
    <dbReference type="eggNOG" id="ENOG502SMSN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265270at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="217" mass="23875" checksum="4B4660C88AC04870" modified="2014-11-26" version="1">MTTPHLPPPGAHGSSAGPRPVPPHVQSRGPAPPVSPNTAHGMSRPVNWSAMSGNPGPMNWHPASSQVQQGQHVMPVARGPQPNSVEPTRLRNGKKIKDVERRQQQIAGAPHEHQTFSGPTKSAVLRRKEQLQLQQRDANSGKHIKTTVGNDNSWVKGLAYSTWVDSPKGTLNHLDREGPYKRQPKGNRNLRKNKRTVSRNSMGKSSLLVEALRNLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPR9</accession>
    <name>A0A088RPR9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_203350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698537.1">
        <property type="nucleotide sequence ID" value="XM_010700235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPR9"/>
    <dbReference type="GeneID" id="22574546"/>
    <dbReference type="KEGG" id="lpan:LPMP_203350"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200039900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_203350"/>
    <dbReference type="eggNOG" id="ENOG502SPV0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267870at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839028" evidence="3">
        <location>
            <begin position="20"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN97830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="177" mass="19503" checksum="2C2D0929FB591894" modified="2014-11-26" version="1">MFSMTKFILATAITVAAVAFPGAAIEFAMAETTTMTAAPVPVNLSLNIVTTVLVLGVSIAVALIYALWKVLPKIRSGELSFSKIDFDWRAELLNQTPKKEKARFAAEKARRAAEMAHREEEMAANRYCDTDEREVPYGSTQPRVELGEVDTLVARSHHEGRKHGENDESVAVTVPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQ46</accession>
    <name>A0A088RQ46_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Qb-SNARE protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_210070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698795.1">
        <property type="nucleotide sequence ID" value="XM_010700493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQ46"/>
    <dbReference type="GeneID" id="22574829"/>
    <dbReference type="KEGG" id="lpan:LPMP_210070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210005400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_210070"/>
    <dbReference type="eggNOG" id="ENOG502S1R8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="546861at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="CDD" id="cd15841">
        <property type="entry name" value="SNARE_Qc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000173">
        <property type="entry name" value="Putative syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="3">
        <location>
            <begin position="142"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN98088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="233" mass="26119" checksum="49751B880CF14928" modified="2014-11-26" version="1">MITNDPFNDSVKELRELVVRAKLIEQQVTQKGVISPSSATELRDTKESAEELLQFLKEMLRVVDERGGRVQGKVFSANEIMERQTIVRSLESDVAEARIFYEKIVASAAQRQRVAEASVAGPGEIYGGAPDEFISAQTFAQREEEKVQDEVLDRLTLGLRELRETGFHIHEELDTQEIMLDNVDRDISSVQVRLRAANAKVDKLLASMSNKGKVGVIAMLLFILVLLAFFGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQE8</accession>
    <name>A0A088RQE8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_205890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN98080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698787.1">
        <property type="nucleotide sequence ID" value="XM_010700485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQE8"/>
    <dbReference type="GeneID" id="22574801"/>
    <dbReference type="KEGG" id="lpan:LPMP_205890"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200066200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_205890"/>
    <dbReference type="eggNOG" id="ENOG502RZDJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="338622at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049916">
        <property type="entry name" value="WDR72-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44099">
        <property type="entry name" value="RABCONNECTIN-3B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44099:SF4">
        <property type="entry name" value="RABCONNECTIN-3B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1006" mass="109888" checksum="6D2EDB98B07AA640" modified="2014-11-26" version="1">MIFVSADRCYVQGKSVRVQETRGVRWCICYASRQCVGISCDTMTIVHVILEAADPLSCTNEVEVCTVVSAAASQTVPNCFFLAHGESRYLTVLHGGSDHIFEKKTLSLLSEEVDRGSDIARVIPTIYAHGCGSLCLLAVVFPDAVSFTAWEGYSLVSIATLRNELSTSFRHAFWKATVHGARLFILRSDSRCLMYDVMMRKSCPAIEEIVVAQQVMLPSHVACLMGGVETGVFLCWRSDTSPERYTVLLQSRAGEDEFELIKVHTTVRHLFASTSVLLLEVIPIHRSYGVVCLFSTGECHVSLYNNPGTVLLALEEHPYDATSCLAFESNSGGYCCVLGFSDGDIRVFVDRQIRANVRAAHCGAVDRLLKLPKMNETDDTFFVSMSTEMGTVCCHAGEKAAVSRTMCSPARPLTACLLNRELQYMCLFSETTGNLWHLPTCRLERAFRSSQGPPDRQLDNLLEHHWASAMSIIRFRYAGGERYAMRIDVGSLLSGLGAAVQPLQRSSPEYSSALGLMLRCLGESCAPSLLIDDALCKALDDLDLVVTGGQTYECVWCAILLLCGLLSHTLDGVSAAAIYSTIQSLGDRLTSSVALDPRRQADAVQLFFSRFFTLRRSTPAPFRHALRLMATKLSACSLADVVNLLHSRASAAQSRQAAGDEAPDAPPLFENGDAFAALLIVLKLASQRTDYSLLADEIFFSRLHQSNLEAQRAVTTALDNDHPLPKWSATLLGLVESHATGCALEETGLFHNFVKALVREAFGGRGEETKQASLEALERLVAQDPQGFLSDYIVTGFQLTPEYRPYIIVFLAHFVKNFPYEAYAVFSTIADIVMSGLSDLSSASQNAASIYHAAVSQLLRVTVASLPSVSLQQTLRHLAVGQRDGKVVVYNVKAGSIVAAFQAHSAPVLGVAYSGNITTLDIATIAESLDEIKVWRSPNQSSSLASFFTGSGGLSFKLVISVDVPSIGLREESLSLLIKYFQLNWLSPQCVEFSSPWHGKLQVPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQI6</accession>
    <name>A0A088RQI6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_211340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698920.1">
        <property type="nucleotide sequence ID" value="XM_010700618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQI6"/>
    <dbReference type="GeneID" id="22574956"/>
    <dbReference type="KEGG" id="lpan:LPMP_211340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210018000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_211340"/>
    <dbReference type="eggNOG" id="ENOG502SGCM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267473at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="327" mass="34946" checksum="445818F71821A4CE" modified="2014-11-26" version="1">MKSIHSGGRIAATTCVHVEVKGSLDIPLNLGLLADLGDPMMEQEIIKEAVRIAVSERLGYFGGVEVQLSSSGGLEGCREVTSPKAMPKEAQIQHQEEAIVSSHSHDINKDCRRRYCEASVNLDELGRCVESIQKAYEGLLAHAQLLHELLNADTAGSTAGAAVVAASPTLSSSAVTELASAITPQSQQLNEVDAHADALKLLAAVRQLVVDMVAEHRPDVVAEAVALKNGASSQRLASHEADMLVEEHAETTAAIHTRRDGKWSSHGNDRNGAEGPDKDDDLDAGLRFGLLAGGNEDAEAQQHQQAEDTEDEEVLRARYIELGYSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RR38</accession>
    <name>A0A088RR38_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Guide RNA associated protein, GAP2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_220610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699062.1">
        <property type="nucleotide sequence ID" value="XM_010700760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RR38"/>
    <dbReference type="GeneID" id="22575107"/>
    <dbReference type="KEGG" id="lpan:LPMP_220610"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220011100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_220610"/>
    <dbReference type="eggNOG" id="ENOG502R80T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276578at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="CDD" id="cd23732">
        <property type="entry name" value="RESC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057320">
        <property type="entry name" value="RESC1_2_CYTH-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25477">
        <property type="entry name" value="RESC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RESC1/2 CYTH-like" evidence="1">
        <location>
            <begin position="182"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="513" mass="56017" checksum="8D6F10E5FB57D24C" modified="2014-11-26" version="1">MLLTHRLTLSMPLVRSGCGRLSWQSTRTRGTCCPSLTVAALCASHRYQSSPGPTNDDARASGPQVALTSRTAKVKYEEVWQLWNEGNLFSLHVAQMRDFLADVGIIVDPTAKKAAVVRRMEAYLHDKDSSEQHGGAAAAVGAAKGAGKEGEQGYGNWAGAGATQPETLLDLAQAGFYQGTANMVPKAFQLLTTGSCAEAVVSRVNTSTFPGFPANTECYTLSSSDATGALQTRYSKVLQWCLLNMNNLRMDGELTVELGKLLLTPAAMRYGEAVVSVYTLQQRLQLTKPYTWVSTAPESAIPLVDAFLTERGFQPVRKNARLTYEGGIKRAKDKLEVVLNDQMKVEGVYGEWVDVQTAFCTSVEKPDCRILLRSRPAVSAQDRETYTRIPVIEFADDDVNDVLPPENGQLVYLSENETRHFERLNDKGIAIAVRETKRQPLIVLRDEEEDPRLEYQISVTIPASAGSHTMDVRAVGLEVLTLADEMSTLLKEPFNEAYRCAPALGAGSVAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRL2</accession>
    <name>A0A088RRL2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinetoplastid-specific minicircle binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_230900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699247.1">
        <property type="nucleotide sequence ID" value="XM_010700945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRL2"/>
    <dbReference type="GeneID" id="22575295"/>
    <dbReference type="KEGG" id="lpan:LPMP_230900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230015200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_230900"/>
    <dbReference type="eggNOG" id="ENOG502SASE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="238810at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045399">
        <property type="entry name" value="Tc-38"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20054">
        <property type="entry name" value="Tc-38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trypanosoma Tc-38 (p38) protein" evidence="2">
        <location>
            <begin position="331"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="648"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="660"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="816" mass="88156" checksum="18693C84EA3C105E" modified="2014-11-26" version="1">MLKHTCHLLVVFTQGVPALKRFAQFNFLPSNPLSSSCLWLDEDDFRATQATASALNVPNPLRIDPYAHHPRLSRFAPAQARVTANQEERVRKTSDAKDRTHNGVVLARTVATHGAGLQAAHAAGAEVPDQLHTAADDYTAGHEVPTGPVPTDDHSGVGAQHSTEEATPLRHRRGRPPGNTVAAAEDVQHYQVPICTVTLTKSLYLFNMDQMYLFEEKGTAMSSLAAHRLGNAEVDGYDAEHVDAITALSPRDRGFPDSEGQLALSVGSPLPRDGSTIIPSEVAPLLWSREHHIMEGVRMLQLNFPNIASDQCSSQGFRRMYSIYSRRPYALMRQKALNILAHRHGYHSQWWGTYKQWLKIGAVPLPGQAEHIVPIAVPSKVVHISLIEDAATVLQRCLILAKHKKLIYFFSGYSDQLGSPESRGGDMGAQSPAHAWQPLRSLSCPGTPVDYGSRVHGFEKMLICMQEDMRVNRWSLPVYFTLRQIRRFELKLRPDAVGLLPASAGAAGAHYSHAAAEVVETENGKVSAADEGATTAADALATTDSASAASTECRGGRALPFGTATIPTTQSTMATARGSAETFQYWYHISQVYFPDSYLVPSVVLTAEFENPGVALNGVSGQRLPYPALLYESLVNQHPEVAAAVRQASVSAEASGTHHATSEVPHELTEHHGSADAQGALPVEGGSGRNQDIASPCASSAAGTFGSAYIKVDEEELAIARFVATNSSPKRTQGRSLWYQAQDVLAAGGVVDVNSAPVEVMERPAALWIGQTEAGSSDVLEHNNKGELRGAVLYNVGCLMEPDEALRLLSVPFDPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRL8</accession>
    <name>A0A088RRL8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Geranylgeranyl transferase type-2 subunit beta</fullName>
            <ecNumber evidence="8">2.5.1.60</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_203800</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="8"/>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698581.1">
        <property type="nucleotide sequence ID" value="XM_010700279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRL8"/>
    <dbReference type="GeneID" id="22574591"/>
    <dbReference type="KEGG" id="lpan:LPMP_203800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200044100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_203800"/>
    <dbReference type="eggNOG" id="KOG0366">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5428259at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02894">
        <property type="entry name" value="GGTase-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000029">
        <property type="entry name" value="Geranylgeranyl transferase type-2 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026873">
        <property type="entry name" value="Ptb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF11">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 8" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="9">
        <location>
            <begin position="16"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN97874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="330" mass="36412" checksum="BAADC36102DDEA33" modified="2014-11-26" version="1">MGELPASSGPIVADLHLKFVHELDDNTQWKAQHLKMNGVYWGLSALVLLRRLDYKPDTVVNFVLSCYNSDGGFGGNTDMDSHLLPTMSAVQLLCIFDAVALIDVERTARWIASMQLPDGSFQGDEWGEVDTRFSYIALSCLRLLGRCNCIDVEAAVQYVLRCQNWDGGFGVSPGAESHAGQIFCCVGTLCIANALDRIDRNRVAAWLAMRQLPSGGLNGRPEKKADVCYSWWVVSSLSALGRIDWIDKEALFQYILSCQDTQDGGFSDKPGNQADVYHTFFALCGLSLLGYEGYNLDAINPVYALSYDALDRLKIAPEYGSQVGRRPPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSC5</accession>
    <name>A0A088RSC5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LPMP_251690</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the diacylglycerol acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="5"/>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699739.1">
        <property type="nucleotide sequence ID" value="XM_010701437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSC5"/>
    <dbReference type="GeneID" id="22575817"/>
    <dbReference type="KEGG" id="lpan:LPMP_251690"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000047800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_251690"/>
    <dbReference type="eggNOG" id="KOG0831">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264532at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07987">
        <property type="entry name" value="LPLAT_MGAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007130">
        <property type="entry name" value="DAGAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317:SF0">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03982">
        <property type="entry name" value="DAGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 17" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="76"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AIN99032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="608" mass="67586" checksum="C20AE88BC9405CC1" modified="2014-11-26" version="1">MDGAPPQQQPRQQQDQWEERVRTPPQQKSSPLGEDATLAAVIAEDGVNTRRRSLVAQVASTISSSFHFLAKEALPRSSGAQRTLNHGTNSCTRKASPRADEPPLTHARPPASREEVEGQLDKVLYAIGQLQQLQQRGRYIASTEVKNLRRAFLFAVGEEQRYQDAVAAHGKACVCSSTSTMPPLPAQRTPPKAAIPTAGPTATGAAPWDGQRMPSLDGPGENVVADAAEIAQPTEGKREYSPKATAADRLLAALERYVDKTPSSTSFDVSGACFSWGSVIHTPGERRLQSLTVSIFTFFTGIPICIAITALLLLSRYTAPLMVLYFLWIFTFGRPSHPLYKSPTFLRLFFWRHYCDYFPVRLIIPKPVRRLFDREGNYFFVYHPHGIHSFGAIINFGLDQNDASKMLNGITIHLQTLGINLYIPLWRQLAIWAGCGDASASCIRKTLRSGPGQSIMLVVGGAEESLMAKPNRNDLLLFKRKGFIKIALQEGTPLVPVYGFGENNVYGVPVLADEPWMRYLMDLFKHFVGFAIPLVCGRGFFNFNYGPLPHRRPIVVVVGEPLVVPHIPNPTTEDLEAWQGKYIECLRKLYNDHRGIYDLESTGLRIMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSC6</accession>
    <name>A0A088RSC6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_250080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699580.1">
        <property type="nucleotide sequence ID" value="XM_010701278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSC6"/>
    <dbReference type="GeneID" id="22575656"/>
    <dbReference type="KEGG" id="lpan:LPMP_250080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250005700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_250080"/>
    <dbReference type="eggNOG" id="ENOG502SAVI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272344at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="297" mass="32925" checksum="F5F746E4EEFBB622" modified="2014-11-26" version="1">MRRGVPVARQSRRRCGGSRQATRTKDFFEGRGERQAAAMEQVPALLPAADTPSPIARPAQTAAFFLASFDPFVFSYCTFDFPTILHHVAELHEYELLDRPESLLISPKSLFLQSSVRFRFGYERQQRLALVLQSLLHEHDESDRSPVSCAHALGVACPLLVPFLRGVCLSVETQHPFAPQAAYVLEELLASGFVSPALYLDGDYGDRRNTLAQLLQLVAREFGSRSALVTGLLLGKEQATPQDAVAVGRLVNHTLATADRRRLDWSLKARGAMRQKLTPKHGWTLGPPLPSSGQRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSI3</accession>
    <name>A0A088RSI3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_252240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699794.1">
        <property type="nucleotide sequence ID" value="XM_010701492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSI3"/>
    <dbReference type="GeneID" id="22575872"/>
    <dbReference type="KEGG" id="lpan:LPMP_252240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_252240"/>
    <dbReference type="eggNOG" id="ENOG502SI3M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273282at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="112"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="250" mass="27725" checksum="06CCD9828F243CC2" modified="2014-11-26" version="1">MDVDQHTVATISEIDRTLRSLGIQDDYPSTLSQPSITYSPLVSVSTAVTRANGAAQTNRSTRVSTGVQKSPSLVQQGVQHSPQQRVTSSQTENETDTQECFEKVASSVVSVNAILEEKLQELECTSNKLDALFAKLTRLEGNANSATKCLHFSQHRWTIYILEREEVSTRSVLLNCESNTRIELISLLYGELVRLVAESKERVLSKPLNGLKRLLPNRVIANPSVVKDTPNSSLNDLTELLDECWRVLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSK5</accession>
    <name>A0A088RSK5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BAG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_210990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698886.1">
        <property type="nucleotide sequence ID" value="XM_010700584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSK5"/>
    <dbReference type="GeneID" id="22574921"/>
    <dbReference type="KEGG" id="lpan:LPMP_210990"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210013900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_210990"/>
    <dbReference type="eggNOG" id="ENOG502SFMV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264640at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63491">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="30946" checksum="BB3CF3D15F46E91C" modified="2014-11-26" version="1">MWASWRSSATLAPEASTSANAAASPSPLLFSSSSIAASPQWRLISTISHKACRQLTKYPAHYIYISAVSGLVLTVTGTVLAYHIVHRGESCERYGRRSSASQTLSHGAGTSSGCAAGQSGGVKGAKAAQVRRGAEKGDDDIEFADPAERAFFSYVHRIKTQKETPLLAALTNLETAAAELVEVRRRHAPQGGLVKHEGSEGGEERGHDSSNAHSDGNHDDVSDHGVVAEAQAKVYRLAAIADELLTQWICSLDGVPVRQSEALKQQRKALVQEAAALARRISPHLPHIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSW4</accession>
    <name>A0A088RSW4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tyrosine-protein kinase ephrin type A/B receptor-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_220400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699041.1">
        <property type="nucleotide sequence ID" value="XM_010700739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSW4"/>
    <dbReference type="GeneID" id="22575086"/>
    <dbReference type="KEGG" id="lpan:LPMP_220400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220009000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_220400"/>
    <dbReference type="eggNOG" id="KOG1217">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="262065at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039181">
        <property type="entry name" value="Elapor1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22727:SF15">
        <property type="entry name" value="MRH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22727">
        <property type="entry name" value="PROTEIN CBG13728"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839096" description="Tyrosine-protein kinase ephrin type A/B receptor-like domain-containing protein" evidence="3">
        <location>
            <begin position="41"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1022"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="992"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1109"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="994"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1121"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1161"/>
            <end position="1170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN98334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1170" mass="126513" checksum="66A3F079781CCD0A" modified="2014-11-26" version="1">MQQRERRGPVTGLLGRRSATRAVSAVAVLLLVSVSCGAAGRPCTAEDITYFYSPCDQRTSKLTVLSYLPSDVNCEPGDLVVPPPRTTSCYNCVDGYHLNPATLECAACPAGTFSSYTTRYVNFDPLPEMLMAYCSPEPCAAWSAVEDTYGTVLSSGLQPTEGRPLTPWGTIDESVESTLDFFTVVTESAGVLEFEYSISSEEAYDGLQLRLNFSLVRNPDHSIGRNRFFATGVHRDWYHASIKLPQGYTKIQFQYIKDSTGPPYGEELTGVNDRALLRNIVIRGTQKTVADMQCINCPPGYWTSTEGVGGSGASECVRCPRNTYRSAHDTQCLACPARTSSLAGATECTPMRVCAASDYIAQYGSCLSDNTRVRSWVKYEGANCVDEEGSRPMATKVECAACLPGMRHAGGQGRGVCVSCPPGEYLLGEECRLCPLGTAAIPTLLYRSGFDDLGGNVTALSGTSLSYFHCSGSARICHLAQGEGFELVAFPFDDEDNTLVGIRQLRSANCTYSLATLNYTFNAEEDGWVNITFAYVDSDGKFVDKMDWRTTMSVRLVVDEVTDYPIRNFARLPPLSDLGFYSLVVPYYVDTALPASDADPNLPGLRHRLSWIVEELAYTSNPISVVIVALEVFGDMAGGVAKCQPCRAGFSCPAGASKMTPCSPGTIQPSARAEVCEACVNNTYTPGYGFTACTRCPSSTIANADHTGCSSACVFERNHMLYNFSDLRDVVLNTTLGNIPGMNTSLSNMTIEEADEASITRFYFSPCDPLPVTDARTTSESDTAATPVTRDRLCVPSVRGRNSSSSAYVCQRTTPTNGRHFGDAVQHLGLGQHLYMLTEQGSLAALDRFSFLGGHWDYYVRPYTVAYIELQCSMENDEPRFGTLEYVGESDGEVLLRWRSAYACPLCTKDSYLKVETTCDDPNVTTRWVYYTLRTDSFSCIGGYVPPEPIIMNCTECTVESYVVRWLDCNATTKTQDGVYVLMPEYANCTPSATPLPPVTPRPCDPSSGRGDGKGGSPVREAVLLVMLVLLLAGLVVLTVYYRQLRERLARAARGEGAELDVYGGILDDMYSHDEEGEEGEEPPLSRGTAATAMHQLWGVLTGMGQHIQDAVLPNDGGGSAADASAEARSGRNGSDSAATSDGGSAHPGGGGQSLFSLAATDEDLLPGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RT70</accession>
    <name>A0A088RT70_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Translation initiation factor eIF-4e-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_260240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699845.1">
        <property type="nucleotide sequence ID" value="XM_010701543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RT70"/>
    <dbReference type="GeneID" id="22575927"/>
    <dbReference type="KEGG" id="lpan:LPMP_260240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260007200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_260240"/>
    <dbReference type="eggNOG" id="ENOG502S3CH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275627at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.760.10:FF:000037">
        <property type="entry name" value="Translation initiation factor eIF-4e-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF20">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TYPE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="182" mass="20424" checksum="533AF575E42186CF" modified="2014-11-26" version="1">MADSTFTKESIPSTPLHPLKDKWFIFYIPASKGNEYEHETKELGYVSTIEEVYSTINTLPPITLLPNDDNLVFSRNKIEPQFESFPGGMRFSIFCKTKTQCREAMTYVVAVVLGEAIGRDACKGESPCDIVRIGHKGSVMYKESVRIEVWAHQSPHNAAMEKYLVSTLSTIPGITVSARPFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTB8</accession>
    <name>A0A088RTB8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_270170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700104.1">
        <property type="nucleotide sequence ID" value="XM_010701802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTB8"/>
    <dbReference type="GeneID" id="22576193"/>
    <dbReference type="KEGG" id="lpan:LPMP_270170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270007200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_270170"/>
    <dbReference type="eggNOG" id="ENOG502S26R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271052at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="470" mass="50807" checksum="5D767A88400B17B5" modified="2014-11-26" version="1">MQDQWKIDVESEDQRSRRDMTEKSIARYVKGEMERQVTSSSTSNSVFVSDCTWIMGASVAQPSYLCCGLSNGSVCLLNTSNLSKIYLFEVDRDSRRSRRDSDHGAEGQGSGRVSFASQQLVAVATHIVSAGANLAAVQALLCVTLDNVVCVCPMDMSTVLERKKVSRSDMAKVKPFPAVAAGAVLHSSIHFNPKGNNILALLCIEQKSSAAPGASSIRYCVAFLSSPDATVKLQSKYTSEEDWHTLAPPSAGGDSCSSAPVELCYCGWWSVDTFVCVWSNSEVQFLNAAGMGVIGGCRLLNHCASDAVTNATVARSGAGEVSDSAASGLVSVVFDHNIAASFYVTTRHNANTNAQELKRHRSEALLTVALIPTMQTYCTEDIPIRELHLVRSFSWTVVLLLESGALVFLDAGTMRLSVHRALNRMRTPDAGRYHAGPLMVAPRDFFCVVSGRPFSAVVVEHNTAFLLRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTN2</accession>
    <name>A0A088RTN2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_261470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699967.1">
        <property type="nucleotide sequence ID" value="XM_010701665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTN2"/>
    <dbReference type="GeneID" id="22576050"/>
    <dbReference type="KEGG" id="lpan:LPMP_261470"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260019700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_261470"/>
    <dbReference type="eggNOG" id="ENOG502SI8C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10266805at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33987">
        <property type="entry name" value="CALCINEURIN-LIKE METALLO-PHOSPHOESTERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33987:SF1">
        <property type="entry name" value="CALCINEURIN-LIKE METALLO-PHOSPHOESTERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="614"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="653" mass="72391" checksum="3587721876EC0DE2" modified="2014-11-26" version="1">MRPLVLSRGIAPPCRAPPWKPQQRKQPSSLASVLFLLGVLCLLAASLIAAAATGASHKPTGKRQTTELLAHVTFASCNRQSHDQSFWMKTIASTIAAQCARGGGNSSKPHTDLLLWLGNALYADVDEAGVAVSVARPSHAIEQEYKLLTENPRYREFVKEVVGVDGRVIGIWDDRDLGLRGADGSYAQSEDIRRLYLGYIWKGYPLAVKDATGDGTPGALYSFTGIPAPAGSPLAALFVHSVCTITLDVRTQRTVPPNLADVLLRRNEEADLRLHGRKETSFDVNLAKIRDARAQVLKADLLGERQWAWLERTFATYLKPTVRSPGDAAGRAHCAVTLIASPWQILLNDNKPFEGWDLYPASRSRLLLLLKKYHVERFIFLSGHAELGELGVMRRSSKEDTRSEAPTATLTDSFLQERRTLPAAKLLPSRRSNLVEVTSSGLTHTVREAPLVGWLTRWLITSRVEEETQSSGLIKRPLFLSRTTTMERQFGTLQVIGDRMAEPRHASAATASREEVLARTRVLITLHSVQRAGAPLVTLERTLANLPSYAAESLEEEEERDAVKAMDLYDVAHLPIFNVYSSPGDYPWLKRRIAEWQCAEVPCVNGQGFMLLKLIANLVLAFAIVLVFIAAVYYYQLKHPDAHEENVTKLKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RU94</accession>
    <name>A0A088RU94_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BolA-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_242020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BolA/IbaG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699541.1">
        <property type="nucleotide sequence ID" value="XM_010701239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RU94"/>
    <dbReference type="GeneID" id="22575611"/>
    <dbReference type="KEGG" id="lpan:LPMP_242020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240027500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_242020"/>
    <dbReference type="eggNOG" id="KOG3348">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="203381at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.90">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052275">
        <property type="entry name" value="Mt_Fe-S_assembly_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46188">
        <property type="entry name" value="BOLA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46188:SF1">
        <property type="entry name" value="BOLA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="10198" checksum="AF51C9E183868B93" modified="2014-11-26" version="1">MFRVAPRLLVAYTAADIQAKLESSEALKPIQSISVVDASAGCGSFFNIDIVSPAFQGKSLIDQHRLVNGVLKEEISAIHGFTLNTKSELPKQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUK2</accession>
    <name>A0A088RUK2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_272010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700287.1">
        <property type="nucleotide sequence ID" value="XM_010701985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUK2"/>
    <dbReference type="GeneID" id="22576379"/>
    <dbReference type="KEGG" id="lpan:LPMP_272010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270028400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_272010"/>
    <dbReference type="eggNOG" id="ENOG502SHWJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273817at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="230"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="453"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="557" mass="60045" checksum="13A45CCAEE95DE36" modified="2014-11-26" version="1">MTHYASPSQSSDRGRCSPRPRTSLRVRNVAVGVIYHLVFEGDVRRLSGKQLRHHLARISHIPPEEQQLFVHGQLFAPNTIGAAVGLHAEDVLDLVQIAKDGRDHNERGSRDGGDSMATVPSPRPSTEAGTLSPTISWQGNSRSVDPRTMRRGGGAGSASASMASSASASTRRAPSPNLLVNAPPPPAKGAQGQTTAGDDLACEPLPQQLHPAPLNDSSLPLWTSATTLSSLPSGNWANGGSGNAESPRPQMPARCTSRSAQGNMQAAVPPYAYPQPSPLPPELRARPSGSRSDRFRRSSYEIASPPPSMQQRWHVPHDSPSPLSAPPPLTSRSGSASRRGVYAAPAAGLNYSHHDDHQSNFCEQASGGPSLSQRASQQQQVYRPRAASSALHNGLPYVAASIPPSAIIRADELETILDEENYIWEMEAYRFRTERQKRLTALQHQQHELELESTRYDQAVAEVERQLARERRKLAELQQAMEQNATVSCSVLDRGRGLQEPLATVRDALDAVARYPPVMYHGQALDHAPNGAYDALCFPGRGSDGGSAIGEEVTAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUZ6</accession>
    <name>A0A088RUZ6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">NB6M</name>
        <name evidence="12" type="ORF">LPMP_282150</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
            <orientation evidence="1 11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the complex I NDUFA13 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700555.1">
        <property type="nucleotide sequence ID" value="XM_010702253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUZ6"/>
    <dbReference type="GeneID" id="22576660"/>
    <dbReference type="KEGG" id="lpan:LPMP_282150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280027800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_282150"/>
    <dbReference type="eggNOG" id="ENOG502RPV9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268415at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009346">
        <property type="entry name" value="GRIM-19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12966:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12966">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE 1 ALPHA SUBCOMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06212">
        <property type="entry name" value="GRIM-19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN99848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="173" mass="20391" checksum="EA18A70889560CA7" modified="2014-11-26" version="1">MVRSTARLLVRDPVPTDTKAFYTWFSGQAYRQERVIPGGYPAVRIYPVYGKRWFTGRTVVALVAGISIFGAWVRPERERYNMEMMIEFAERQAAHLPYQTAEVNLRCFISGYKRYRYEKENLIDKGYVGLTSEFRKFFYHSDVWRPPLHDVLMHPYVKYGGPLGSYNWSVGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RV21</accession>
    <name>A0A088RV21_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_290570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700665.1">
        <property type="nucleotide sequence ID" value="XM_010702363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RV21"/>
    <dbReference type="GeneID" id="22576821"/>
    <dbReference type="KEGG" id="lpan:LPMP_290570"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290009800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_290570"/>
    <dbReference type="eggNOG" id="ENOG502SGK6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266987at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="480" mass="51880" checksum="02F030CB45F26E80" modified="2014-11-26" version="1">MPTTSASSPQLLALRSASGTTMAPHFSTAAAAEAAATSSDQEMSVKTVEYDEDWHRLPSDISYVQDLLASLETRQHGPAAASSPLAAMTGGPSYTTAAQRDKEQEAREIADQRVRERQVTVIEGRRCRLQRRCDAIDEAFHNALKRRWHAMQHLAADPPAERLVGQGMTQYVPAALLPDGVVSRRGVRQPGLIPLVPQSAVESQMCRAPNALAIKEAGPASAATVRALTDRSLGAPAEQDTIVFLTQLDPDGRVVRKEEAAGHSYSPNPSPSALSRAVALDSGKGRGKHEAPPLTSACAVSTILAEASMNADADEDGDDEGAWMRPAIVTEANKAHWHEMGYRVVVVGEAGPCSSADRREADAVRRAIRSATTSSSEGVAPCAIEQLTAVSSSPSKRRKPPSDKQAKHTVGPRWDWIQLAPLPPMCLVQRRLPEEDMTVAELRKQHHRRTPVASSITSELCGRQNRRDRSWRMSSKPAPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVZ6</accession>
    <name>A0A088RVZ6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_292070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700811.1">
        <property type="nucleotide sequence ID" value="XM_010702509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVZ6"/>
    <dbReference type="GeneID" id="22576970"/>
    <dbReference type="KEGG" id="lpan:LPMP_292070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290022900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_292070"/>
    <dbReference type="eggNOG" id="ENOG502SJ2S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267580at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="109"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="427"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="689"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="109"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="696"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="742" mass="78115" checksum="4C78AD848ED5C0F7" modified="2014-11-26" version="1">MGGALCTRQAHASNDRALFVTPQSAIRNSENLLSDAMQERTRVTAAKPLDTLSVSQPPTLQYVKTSWATHSVRSHEDTTVHRSSASNGPHSTLHHGAQPLLSSSLLSNQLSTQTPSHGASKVMAAAPAKAMPRSASPIPEMEASLSSSRSLFSLYSADSCSDELPLPPLQPAPPLQAAETRAMASATLTETPNTTAQYPSATSNAPFMKKSILSNAAALPKALPVTPMPAMRNLVPENDSRNNGCTVTSSHDKTPEIDSAQAAPRALLTWPSNEAAAAAAHAVSSALLEVSFDSRALAVSNETTFSEIQRIANRLRELQDERQVLGEALQVCGLPSPSASADNSVVRTQPSVSEVSKVTSEALPVAPTALLESSQRSFESLSSESVLASRQFYDETAKFLNSIREIHEAGKTGQGGCVWFRCGAAPPSTNSPSGGGCGEVETPSDAVTRTSPPPAVEAASFSGTQRDDAPVSGAVSDLRLLISLRRRSRTSTCVRWLPFEVSESDLRTGSVITPVCSCGDQAANAFAYDTGATHSSEHFPVKGVDLVTASLQHVPERGASSVTTPSVVGNSPLPSGVSFTGLSSPLGQDAEKESTAILNDSQGPLSSSAGITTSTSAHSISSDNLSLCPVHAAHRPVSILISKKRRRSASSISFSLAQKPPLKPLQVAVPTTATTELPTPKLASALLPPFDLQHPANDRPTSESGRRPIINSGVPHRKQLAKRALEDNKLFFEILSRQRSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RW86</accession>
    <name>A0A088RW86_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diacylglycerol kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_300440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701079.1">
        <property type="nucleotide sequence ID" value="XM_010702777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RW86"/>
    <dbReference type="GeneID" id="22577098"/>
    <dbReference type="KEGG" id="lpan:LPMP_300440"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300009700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_300440"/>
    <dbReference type="eggNOG" id="ENOG502RYS5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3853857at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001727">
        <property type="term" value="F:lipid kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF31">
        <property type="entry name" value="ACYLGLYCEROL KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="2"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="367" mass="39288" checksum="3FE426093403E133" modified="2014-11-26" version="1">MPSLKRCVLVVNSRSGRRHAVQTFASTLKGYLDRAGIVHHDVHIPNDDAAEQLQRALPWAEALVLCGGDGTVNRALNLIASMSFTGTGPSREVSPRSLLEAVPLLLVPTGLHNSIATSLGVTSAERAVSSLVVGRTARVPLWAVHLRRPHSSSSAFPMRYMCSYVATGTYAASVQRQSSWKEAQEDYVFLPAGLRGFAATALFTTIEHTQPNSTAVLTHMSNKGVASSKVGPLRLLVASQMPQLQPGYSLTPTATYHRRQLTVTTATAEVSRLRMWHLLHREAKEGCILAEDGVAMQEGVRSVRIDFASISELSDAATSSTQLPVNDEGEGSPESSLLMVDGEAVQVPAGSSVTVTPTELSVQLIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWD0</accession>
    <name>A0A088RWD0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_292590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00206.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700863.1">
        <property type="nucleotide sequence ID" value="XM_010702561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWD0"/>
    <dbReference type="GeneID" id="22577022"/>
    <dbReference type="KEGG" id="lpan:LPMP_292590"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290028300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_292590"/>
    <dbReference type="eggNOG" id="ENOG502SB5C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265243at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO00206.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="693" mass="71007" checksum="F5B89ACEB42FCB29" modified="2026-01-28" version="2">MHRNRIRVRPSGSNHLSSGTNSMQHMSFDGTDESLHNCRAAAPQPAESSFAAHNSQAWHAQSSSLPGDANDSGEAWRYARRIASLAYDTVSGVLGVLRAKPCKEVKMSKDNYTPLKALSSPTVPPNTPHISAATSAQSCCGAQQPSDEAHMADTIELRRPRHSTFQYQALPPQPPVSESAPQMREVPHMHPSMRGSPQYQITVNQYFAAPERDLYPIVFANPDQAAKHSGASAYPSRASLLTVPSSVQGYAKRPRLAFPPAAAEELRVRKAPKTATDTNTLDVSLSNAPSAIPLDSQDNSLTVPIASLAKQRLFGRTKATNKYDAPVTAKPSAPLADAPTAKAPLFGGTATANAAAAPPNFIFGSKLAEAAPARSAPGAPAFGVSKSNSFVKAGPPAVIPDDNGFAPNADSDDDKDVKSATDNAAPAKTSFSFTPLGTKPTFGAVPPSSAGAPPNPFSFSAKPAEAAPARSAPGAPAFGVSKSNSFVKAGPPAVIPDDNGFAPNADSDDDKDVKSATDNAAPAKTSFSFTPLGTKPTFGAVPPSSAGAPPNPFSFSAKPAEAAPARSAPGAPAFGVSKSNSFVKAGPPAVIPDDSGFAPNADSDDDTRSNNKRAKAESASPDGGSGAFSFSLSSSLAKPPFGSGLTSAGSPSFGASTGASGTAAKPFSFANPTSTGPFGATYSSGFPFSTSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RX48</accession>
    <name>A0A088RX48_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CNNM transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_302990</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701321.1">
        <property type="nucleotide sequence ID" value="XM_010703019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RX48"/>
    <dbReference type="GeneID" id="22577352"/>
    <dbReference type="KEGG" id="lpan:LPMP_302990"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300034600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_302990"/>
    <dbReference type="eggNOG" id="KOG2118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5353557at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010960">
        <property type="term" value="P:magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045095">
        <property type="entry name" value="ACDP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF97">
        <property type="entry name" value="METAL TRANSPORTER CNNM-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="7">
        <location>
            <begin position="15"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="314"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="416"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO00521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="451" mass="49357" checksum="910814542EBB89C2" modified="2014-11-26" version="1">MESSHSHGRGEEGLSNAQMLWYSVAAVLCVAGAGFFVGLQIALFSIDRLYLRVLTTTGTPKERQQAKSLLGVLKLQHWTLVALVLMNAVFVMTLPILLEAMFDELTALIVSITAVLFAGEVMPLAVFVRWAIPVCSYFIHAIWLAIIVTAPVSYPMSKVLDHVLGHKEELLDREDLAALIVGPQLGENDESAMMEVAAVRVGDGGDENAQMTEKTSSSYQLRDSEVKMLQAAMRLSTDTVEQHLRTKAADAFMLSSRDSLDRETILRILTAGYSRVPVYSGENRRHIIGALVVNSLASLCFSQPDPPPLVSDYPLREVMKLSQELSLYDVYLAFRNGPSNMAVIYDSSGAMVGLLTLNDVLAALYNADPVEPTELSRQYLHRQQKMVELVEGMKFLQATKRVVSMPLGTSRPGEPGSKKEQTGDAEDHIAAITLLPAPRHGVSPATPPPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXN2</accession>
    <name>A0A088RXN2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome b5-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_290890</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700697.1">
        <property type="nucleotide sequence ID" value="XM_010702395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXN2"/>
    <dbReference type="GeneID" id="22576853"/>
    <dbReference type="KEGG" id="lpan:LPMP_290890"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290013200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_290890"/>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10051395at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000007">
        <property type="entry name" value="Sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF146">
        <property type="entry name" value="B5, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="15"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="116"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO00040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="168" mass="18890" checksum="00D401147C6ECFF6" modified="2014-11-26" version="1">MLKDLLLLSGLKKRWPVISEEEIRMHNTRRSLWIVSGNSVYDVTGLLGSHPGGEAAILRRGGGSKNCEADYTFHSRYARREWDNRKVGEITSEVAMRLFPPRTGTHEANMRSATECAAGPPPVGISRTHINSGEESHTRTVDTYASTTVSPDQQYHRYDYASCRQRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RY74</accession>
    <name>A0A088RY74_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_292830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700887.1">
        <property type="nucleotide sequence ID" value="XM_010702585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RY74"/>
    <dbReference type="GeneID" id="22577046"/>
    <dbReference type="KEGG" id="lpan:LPMP_292830"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_030014800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_292830"/>
    <dbReference type="eggNOG" id="ENOG502S83C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277654at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="244" mass="27791" checksum="5E1F5F578CE04FEA" modified="2014-11-26" version="1">MPRLIHASHRPEGGRGNEKLTKSVPKTANDLAAQSLANLWRRLFQSYVHFTQPGCEPFVSDSITDLDCVDDVANADTALDTLWAAGFAASSAPDALIVHLFLANEHFDAVSWIIAFCLVDRLQLSHYVRQRLRELSFLQPRGNSSSCFLRLAKAHVTQLLFTAYSLAFKWHLDYTVSVKYLTSLLPHARSTRGRILHRTIQEELRVLETLEFNCAVSQNHLLQLMDHFLTASERRYVLHVVHRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZ01</accession>
    <name>A0A088RZ01_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_330900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702183.1">
        <property type="nucleotide sequence ID" value="XM_010703881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZ01"/>
    <dbReference type="GeneID" id="22578243"/>
    <dbReference type="KEGG" id="lpan:LPMP_330900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330013600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_330900"/>
    <dbReference type="eggNOG" id="ENOG502R2C1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272681at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978:SF4">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOTIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="417" mass="46186" checksum="F8C2D090760DDEAB" modified="2014-11-26" version="1">MLRFAGVLRRAASATPLPPPPPPRLLVLTMIPNGGALAPALRILGYHPYTFEDSVRKGRLLTHPQEWMAVLRGEKKFDVEVLRAPQHATSTKGAPSPSSGDTGAPSILGSPRISKTPSASPQGPLFFDSIVGPPATIAFESILKECPRSTRVILVEEPDKLAWERDIEQWLQPLVLECKRSTTWWNASKLHMMLLDMVDLRRALISPSSQRSGRVRLPPSSSAAMTAQNVPISKQHTTLRLASALDLFEQHVKEVVPRDRLLVYRVGDGWQPLCDFLQVPVPMAPAAASCAPMEPVAFPPNSTGREILVFVYQGLKKSAAVVSFLFLCVLALALLLLSSFTGEYTQFYRDYRDYVRRDLEPYMDAEKIREGDESALTIRQALVMTKKSSKRFGEEYEMENGAMSSMAGVMERIVGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZK4</accession>
    <name>A0A088RZK4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_331570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702249.1">
        <property type="nucleotide sequence ID" value="XM_010703947.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22578310"/>
    <dbReference type="KEGG" id="lpan:LPMP_331570"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330022300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_331570"/>
    <dbReference type="eggNOG" id="ENOG502QWB2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="286233at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="1185"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="17"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="178"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="343"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="507"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="628"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="750"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="906"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1231"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1495"/>
            <end position="1554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1581"/>
            <end position="1612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2202"/>
            <end position="2266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2284"/>
            <end position="2337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2458"/>
            <end position="2504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2792"/>
            <end position="2823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2873"/>
            <end position="2896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="354"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="367"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="507"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="639"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="753"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="930"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1495"/>
            <end position="1504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1506"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1581"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2243"/>
            <end position="2252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2285"/>
            <end position="2302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2461"/>
            <end position="2474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2794"/>
            <end position="2815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="3111" mass="331889" checksum="C28F9FC746CA0CBB" modified="2014-11-26" version="1">MRAEMIDALDVCLQEVPEDPHTWGGSSASVPDDERVRNGKTGADAPQLLLQERSSGTLDTAADSNGDGLLEGMETESELAVSRQESSTSAIPQGITEPSTVVAQEPPSLVDLGHYEWRQLLMEIINVLVRIDRALLYNVRLRALERLAPATTGVHANAAPEFRWEHLSQAFLTPAASGTPLTAADATVSGSRRGQRSHTPTRGPQRHPPHGDAAPLNSSLPNRNADPAVVAGMATPHERAVTPVTITAARADSTSSPSVKVKRGLADSGIVSPDPSADLAITEVDKKMLEEALTIACSLATWAIVKAILRHHLHVLEQRQCRRNLTLLTKATTTTTASARLSADMSMSPTSMETAGAGNTNTTGRPPLAPPAPPPPAAMNDAACSNGAAEAGAGAGATAATDGDQSKNANHMSALDDVDAIPYIDWAAVVQELAEWMGEQHFVAIAECTLCASFLRDDGREMVLCMLQTPKPRWLLTNIHRHAEKLRRADVGSLLSGSSPLRVVTTATAPAGSPTTTVTGVFGSAPASTSSTPASSGTPSASSGSGAAAATPPAGATMTPNRTRTTLEDSALVMDDLVARLEMTYRKAVANTWASYLEDAIEADVRHLSIDAAGDSDTSRASTPMTHLTTAAEEPPKHSTGNLTSPSALSPLQQEHITDTKTLCRLATAFFFGSDAWSESKRERCFSLLSRSMRGRMERYSESAATRRHLRRGTTCVTSAPHMVTPAVVAGSLEPHPLVELTTAGAAVVTTTPSSRGTSQSQSFTIPPQISTTATPVPSAVSGLTPSKFSVEDTSARVSPSAGCPSAASNAASVGTPVTTRHGVASSTQVVGSQLLSSNASTSAISHHSTPLANSLIVSRDGISDMEVMVPGGGGPISESGLFTAGHTDRPTTWTPFAFAMTPSEPITPLPEPHHPSSSTTIQRDEEEGHQEAGEDNAGRRTMETSALSMPTVNLQVPPTAVQPAAFKGWDSALGSLVLERIVNMSWSAALHKRGEQCLTAKPPRLEEAEQDALEERLVASAFGEFRARQRAIVSLINARLASGKSVEALTNAQKHFKFEKKDWTSHNQTIFSAMRYLQSMVFLVRAQAACRVYGAVIETVQFVLPQAALCEQMVQVLAPRPRGDYILRFGDCRSKLIRSYVYLLKEGWLAHAAFNDLAKAEKYFIKCAQVVQLLRRRVRETELFAAYMERGAQLMKLKEYKRSVELFRYAVSIAKKSLQAADAAAAANASGDSGTFSPNASTGSTAPSLGSAMTNMENAVSVAAPGLAAKAPPAASQQQFHRNLHLRAAGSGSLTTAEEHIPGVTDAIKDDLELVWRVAESERMLALSYVTQAEHEVNVRERREELSNAVSSAYSSQRSLQRWQRKGGTPKRLLTAVPCSLIVICKGLLLLNQPRKAALLLEPLIENKPNTALVRPPMWGEILHPTEDPYTTEDVVLRTYVSSVKIAVFMLYARCLAEFDGDRALRAVTQVDQLLKESDTWICTIRTELRRALEDVSSKDKTVADSLNSPGTAQSIEALRRTSAASPHGTAGNRQNSEDGHSNGRQDYGAGAETSAGTSVFTTVGKSKACTTDVPTLQIPISHSSTASPSPLDDSRHRPEWNSPDDAPLRPRRVTAAGGAVMEDDYRSCRNTSTQLSVIGGNRSETDLFSLVNNTNAVISSSTAVPTARSSSSPSATVPHLLQLPPIRVHTESSSECMTALFALREAKSHIRKALRGIFIISGDAHSLIKNWEEALKVYSHALVITMSEVEAASAAARSRRRVHQITSRSCFSSQQSSTSPMGADDGGSLSAPHDAYKAICNTVGGDPSASLQGWGPVVPLDEEFFLWDEEDVLIADNLVNRELTASTAAKDLRAVVADEERMDSRACESVVLSKLANVYRALEKPTTAIHYHTLVMEYANECHDKLLAYNSMLSLARLYTAANMSDKARDAWAKVSELAKEYEDKEVSRETMRNIVAGQEAAGMYMDVVKTAEELEKLATGEEGEDAARDSRFALEALANANLHLGHFDACIAALDSREKVQEKSAEWSGALLSMRAKARMGLNKSAEAIKVMQSWAAKARNLGNWVELGKANSALSAAYASENHNMQARCHHEATLNAFALAETLDEECRHIALESARWLVHYTYLDDTTMQVDPALTYTDRGGLSGGSEESSVDFHYVDSGLCNSSGDLGEMLAKEELRRTSLMNRKDYRLGFNNDDDDLGDGDLLSNQSMFGGPPPGLSRADTLVSKGRGMEEEEQRDDCAMTRAEEDSSEGAAAVNDNDAPLTTSSFISAMLMPKDSGVVTQPPSLTSSISVSMRRSPTHLDSVLGGGNDHSEGSSSAGQSDGGDNEAGEDVEDDALRPMDVEDVAEHRQDPKLPVSIESEEPFDLANLKKPGPKPTPVAQTPIVTTAAVKPTVNTAAVAGSDAPLGKSASSTYVPPPTSLANVSICSRPAAAAAGTDVLELPVDVCRSASEQATLSGPSTTSSPLMSNSPRGASFQAGPAATASGGDDDGAQERKPSTVRTTYLRGAIEMIETAAQLLLMPRTVRHIVIPYSPAEAVDFALIAHPQSLFVFYFAEYTTEYGAQCDVVFRPPHAASFMKLRAQISLQEYHSKDAMSALLAPVSAEFSMAGEHNSATETAGSASSSAHPFGTAMARAATGSAALSSALSNVTPDALRAALEEETSTCLRNLYANAWQPIADRMRREHVSYQDAETLIIMPDVSLMHLPFAGFLPSPNYGDEEAPLGEQFTLIVTPSLTHFVHYGMTQQPQRSHETSGALDPAAKKYIFLPYDSSAGSGAVTPSAPLTMPTFTPYSPSLSNTRPQQQQPKTGTDAGANSTTSALTVTAGVVAGKATAQNPAAPSVSCAHSLTDPLLTGLPLAASATAGDISMRSNPVPGDPTPATSSSAPQQIERDDTFDDLLRTWRVHCGCTRKELIQAFTDVHTRALMFLAPLDQGVIRVADGVVTIQDLTQNLQQVRAQQPATHVASLASNVSVSPTGPTVTTVPPTPLASPALPLPPLCSHIDLLVLTANRSQYPTVSDAGASAKMCMALGVHRVLQLNILNGLTPNDEHHAFIALYLTNLKKVMRWSLQNPYAVALRTTMAEARKLGMSSNTWGAFTLVGMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0Q2</accession>
    <name>A0A088S0Q2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_341440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702571.1">
        <property type="nucleotide sequence ID" value="XM_010704269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0Q2"/>
    <dbReference type="GeneID" id="22578649"/>
    <dbReference type="KEGG" id="lpan:LPMP_341440"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340020400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_341440"/>
    <dbReference type="eggNOG" id="ENOG502S36T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="239554at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="575" mass="66089" checksum="63427069F67150B5" modified="2014-11-26" version="1">MPTKSRHSSSLLFHRIGLASAILVVVCLALGYHTGYRSTEHWFQPRLVELRTLERKLKVALRMCKDETQTLISSEQLKNSRVREMIRMVAELEADQRKEEDVYKTIEMKRENCTATQAQLHRQVEEQSESDALLRLEVEELKDGIDTLQVSIKKIMHGERIPIVMLNQGLQRLRFLYADKCRLTPGCVELTDAELIERWGKATADEAIIKEFVERGEEAQRTMVNNTFPGASGNMTDIVLQPTLLEEENTSLTSKVPLFFNRSTYETPLCGVDKGAASLLPIRVVTALEQFTDYAFCAYRYHNPNFTFQSAFTYSSDTMSRQEQEPKKGIVTYLHELVVSPLLRFCIDCKFDTREMNYRLACLTDRVHSHYGTHDFWAARSLIQASPSVQDAAFRYYEAQNWHRKKILAVVLHQAIHHDGLQCDNLVGRQYGLHYQYLQSNYPNITAFQQHISDEHRLQCSPSLEMVIEYIQKVRSQAPYTFDHVYLSMAKEQRSTLESLLRVNDATQLLPLLLPVYTNAETEAAKPGFTELVDLEITGRATDILTNPFLSSSRYVTEIFLLRNNLAPGGHVWTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0Q3</accession>
    <name>A0A088S0Q3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_343600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702783.1">
        <property type="nucleotide sequence ID" value="XM_010704481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0Q3"/>
    <dbReference type="GeneID" id="22578865"/>
    <dbReference type="KEGG" id="lpan:LPMP_343600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340043500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_343600"/>
    <dbReference type="eggNOG" id="ENOG502S8E2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="249020at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="842" mass="97512" checksum="8E96042DF489AAD1" modified="2014-11-26" version="1">MRHLHVRIRNFYEDDDAEPAKALSEEQRQFRPSPWPFSAPFTSPRAGDDAQPHGLVADSVERTVLTQDVERSESSHNNSSYSSASIERVIHCEGTTFPPSFTSNSARNFFVGDKHVSLRLLEESVEEAVRDVHRLDVLTRKAVWHVLTQKPSTRDAKLRRRSATASAHKVSPGTQRGASVSTEVHHSSMGYSGLTALVHDRPFLPPDRYPTTPALQGTPDHFARNLSGALFAAHHAGLFEKQRVWMQHRLPPRTTEATVVARIPSSSPTSTRRKALQRVSSLASFAAVASRSGRATLTSIGSRVGVPMTDPVDSEAELVRSSVSLIILRVAKDRAIATVFLRQLHLEVCKRRVLRVGADVRYRYYVQRRLLRRWSSAAAMQRRWRISLLMSIILHWQRYVRSRKALHIVLSSWRWLLQQRSRAFDACQQAQRQRCFQHWLRAFTWHRERIALYEAASQFAASRQRRHHVQALLEGHGGDSEVLALLQGRPHVSGKSAVVVTAVGPRLLLRRLFLAWRQRTEWRLVAHLAVWHYNQQMRANVIRRVCRCARRVALQHHRSCPEHQRQRSASVAQSVDAASSVMEGQSRTPLRVYIVAVKQRGVFKYKTSAAGFIARAAQLRKCFNRWRIRGQARRADRFHLQCVYAYAVCRWLQALAALRARRQRKQQVLFHWVVATQYCQTAAVASKLHIYQLSCRALRRWRSRLTARLRHRVQLLQGCFERWRERAVLRRAARALQCTRKRSLLQQWHHHAQTRVQMRTHLYVADTISETALVLGCFRRWRFRAAERRRAHLAWDILMQLRRERLSRRCFDVWRRRTFGPALPWAKNLSKDRSFPAMPLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0Y1</accession>
    <name>A0A088S0Y1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_342500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702676.1">
        <property type="nucleotide sequence ID" value="XM_010704374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0Y1"/>
    <dbReference type="GeneID" id="22578755"/>
    <dbReference type="KEGG" id="lpan:LPMP_342500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340031000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_342500"/>
    <dbReference type="eggNOG" id="ENOG502S8RR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266402at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="304"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="387"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="668" mass="71307" checksum="E549DEEE7985E8AF" modified="2014-11-26" version="1">MRSTETPSQDMAEPLPSAPLLEVATSTRFPAPGGDDGKREEVTMLSGFSPSVSTVDASTLVGPTARDKLTKHPVEKIVVANEGASTPSLVGDTTQFRITKRLPFLADTEGTEVILGETSQGFLSSPLPSSATTCNYHCTPQHSTDASSPEDKELDRHVDGGDDDDAARGNAIQDKYNITSGWVDNLPTGDSTASLDKPMHGTASSEVPSVAPFIGSKKRRRGGAGGKHDPANGGGGERKRRAQRADDAEVQAAFKHSQRVLRKQAKSVNMRDVFSQTLSLPLPLQVPTDTLGNPSSFPSKTPLADTPTNDSDANADAATTATAGVSSSSSLRIRSPACSPASLLSPSSPSSSSVWSPGVVGELTSRFLAQVQQQKRQKFEQMVSRELTQSQTLSQTQSLTQHPRQHGDAENGQGSGDGEYNPRTCTYYGMANDFTIPVDELVIGDEDNEAANWMPADPSSPTSQHARRMIQRDPVTSDETVLLGASSGEEGRFASCSNTLAEGQKAEDEEVSQQQEQAMRSLARKHEIWKLKQQQLRAQEQVELDERAKAMQKQRSTKLVTAVTAAAASSGNIHFARGDAEGTPATPAPLFTCSFRTYQASATGIDRGNDSGGVNATVAPRSTQSAKLSAEAISMIRRINSFDNTSTQRVVVFGTAASKQGKDKRMQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S106</accession>
    <name>A0A088S106_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Replication factor A protein 3, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_343280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01954.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702754.1">
        <property type="nucleotide sequence ID" value="XM_010704452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S106"/>
    <dbReference type="GeneID" id="22578833"/>
    <dbReference type="KEGG" id="lpan:LPMP_343280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340039200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_343280"/>
    <dbReference type="eggNOG" id="ENOG502SA78">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276803at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013970">
        <property type="entry name" value="Rfa2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08661">
        <property type="entry name" value="Rep_fac-A_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO01954.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="241" mass="26974" checksum="0BAB3E955C8C728B" modified="2026-01-28" version="2">MSTLLIPCRSPHFCLVQLITISPLSPSARILPSVPLPLCSCCNNHTSAHVRAPLFFFLRCFVHDRHFLMSKLLHPHTRTHSSAHPYISQTSPFYSNSLISSRSSTLHLPRTPQQKKTEGTNTSSMYAQHIQAAPSNKLPVFQGVSPRVTAQTYQSHRGEYVSIIFELTGPGEFKCGATGMSVKVVGVPEAVEVSRVCEFICYVDPSTGELTYFQHAMLDDEFDFEVYRRLVSLTTKVPQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S140</accession>
    <name>A0A088S140_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Replication factor C, subunit 3, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_343100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702736.1">
        <property type="nucleotide sequence ID" value="XM_010704434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S140"/>
    <dbReference type="GeneID" id="22578815"/>
    <dbReference type="KEGG" id="lpan:LPMP_343100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340037400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_343100"/>
    <dbReference type="eggNOG" id="KOG0990">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10254700at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000012">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000004">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000129">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF9">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="49"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO01936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="364" mass="39949" checksum="71C3EDB7F614FD76" modified="2014-11-26" version="1">MYAGRQGEEGKVAASHLPWVEKYRPSTLESVVAHEDILSTLRHLMNSGNMPHLLLYGPPGTGKTTTIKACAYYLYGKDRVRANVLEMNASDDRGIDVVRQQTREFASTTSIFSVMGSSSSTGSGSGGSAVKFKLVILDEADQMSHDAQAALRRVIEKYTRNVRFCLLCNHINKIIPALQSRCTRFRFAPVKKSAMMPRLRYVAEHEGVKYTTDGLAAAYRLSQGDLRRCLNTMQASALSANEITEESVYRVTGNPTPADVTTIVSHMLSSDFATSWIKTEEAVTQKGISMADLTREIHPVVMAMDLPQDCKCFLLMKLSDLEYYAAGGARESAGLGGLLGAFQLVKETVVQRKPIKDVAGDCAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S184</accession>
    <name>A0A088S184_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_343580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702781.1">
        <property type="nucleotide sequence ID" value="XM_010704479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S184"/>
    <dbReference type="GeneID" id="22578863"/>
    <dbReference type="KEGG" id="lpan:LPMP_343580"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340043300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_343580"/>
    <dbReference type="eggNOG" id="ENOG502RXHB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277282at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="38949" checksum="A4E88D3BA5B1114A" modified="2014-11-26" version="1">MLSWWPFQRSRQPFTSASDASPSHSSDVGGSDAKVPLSRSLMDTESFENAATGKDRGYGDSGVPYSQFDRMRDEQKIRRHGDGRASTMDVESIDTLVNRFENEFRQADVHMKAREAQRSFLQRYDYANDRRYQQWRTEQKEMREKLKIHWLDLMIDQPSVCLVYYLRVCTTAGFCFGAGRTAYLYRTMDKTYAKLNGVTLGGIAFHEITTSVAKSGVVALMGTIGMPVGDALTSLFMMLWTGDVSSPHRTWWHILNASLCSGFLGGTAYVCFNYKQLTPWGVRALLSLSTGFGAAAGLYMGYVIYRPYAAQRTHDLYDPYWRPWHTRHQRDAGPSNMRGKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1S0</accession>
    <name>A0A088S1S0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_332240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702315.1">
        <property type="nucleotide sequence ID" value="XM_010704013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1S0"/>
    <dbReference type="GeneID" id="22578377"/>
    <dbReference type="KEGG" id="lpan:LPMP_332240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330029900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_332240"/>
    <dbReference type="eggNOG" id="ENOG502S0RV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267682at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="874"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="874"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="902"/>
            <end position="917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="934" mass="96216" checksum="655190DF49F09AA3" modified="2014-11-26" version="1">MLFRDQHDSGNGAGAVGAGVVNQHNEEDETCSTGGRSYTSVESATAQHFEQRMAQLNDSMYPISDISSGAGGFCKAAFGIGGGAHAYLTPSYQLFPKVDGTYADIDTDDIDDMQRSLSLVAQTSNGEDSGLRRASHTKMSTELKLESFTDGKDEEDAGYLASLLKNIERHAERLDTKFYRYPPSEVIKQQIAMTAPPIEEKEKVHTAATGSGAASAGTGGAPTSVGDDSTAEDQSGSVGALSPWSPSQVPTEGPPAAPSSTVAAAPASSHSSGTKLFLGGLRYEVIQSGRHMVSWIFQVACGVRLSPSSILIHRKTKNGRSNVAPTGCASVFVAKDADVQALLRMNQRIYCAEEGIYVSPSPEVMKELIASKDIVDVTGGRVRGPTHPVVIERAYSLSHHHGQREDGGSGTLAHSSVVGGAAAGGSGGHRHARTSSASTESNLSNQHWGAMPPPYGSVPPPQYGTSHASPSGMPGSLQPPSYTTSSVSSSMGVDAVLVAGSLPTRVSSTTLYPSSAVLSEQSSPSTQSMVGDARMPSPPSAAKALDLQRVTFHAYLHSDAMPHLRTTASSSSGMSSITGSSAAHHTVLFVAALPTETTPDYVSWLFSLMSITLPPSHIHIIGGGGGISTVSDPPGGASSSSAAKNMVDSCATVNLDESDILIALNYHHRVLCTSRGAWVGHSAQDIATLRASDASLRDWPVLHVGRRMPAQAVTGVGSGSAAAPETPGYPHGGAGGEFARGSVAPYPPMLTQYPSPVFGGMPMMSAAVMGCVGNAMPYPMPWGFNMPSPSSNCMHAGVPPPSSQAGMVGGTMAPAMGAGAPPPPPLNLALPQQGIPVMPPPFPFPQTVTIGDRVYQLPPGSTLQFMPVITPAGGAGAGGEAEAGMGGASGGHWRSGPPGHGSASNAEASARPNTSSPHPDMPLPFSTRPLQKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S222</accession>
    <name>A0A088S222_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_351520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703089.1">
        <property type="nucleotide sequence ID" value="XM_010704787.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22579181"/>
    <dbReference type="KEGG" id="lpan:LPMP_351520"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350021000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_351520"/>
    <dbReference type="eggNOG" id="ENOG502S3H0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="245575at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="719"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="804"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="866"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1215"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="614"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="719"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="743"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="890"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1035"/>
            <end position="1075"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1313" mass="145032" checksum="4F690DAC64EF700B" modified="2014-11-26" version="1">MKSGQGVKKGTSDAKEKLENHRGNALMRNSTSSKEKEAQVEESWSVVRASKSSTLSQFAASEHVVHAAKGSAQAAFTPAETPVAPRSRTPTPVMAPPTASDARTNDEEDQMSIPTPSIRTIRLSTSPKAERSPAAAESTARSRMAAGLSPTSMDSIPFSWSDSTKTGTSIEFAMDGASSEDTMSVQVSPRRCSPCAVENGASGDIDAQRLPGKHDDVGHHAAAVSDRRSESSLELCVGDDTLEKKVLTPSVMAAGDDEKGQKEGERLKASKQTAPGSSKQAPSSTQREASRKRAGSAGKATRHGAYAVSSADPKAKSSYADIGAKAAMLSQVNSLLATRDQPKTSGASKRKGETPRGEQRSTFSSRGHDLVDSALLSSHSSSEGSLRHRRSCGSVNSIGEESAECLPNRQGHSGRGSRVTPVRYNEEYDDDQQSVSTTERVREFNAPRSCRDVNVGSIVRGRSGGMFSGVANERSWRTPSAPWGAYHYRDQGLWGSRHCHSLSQSPVRRHGSRYMAVGGLDGAALVQECLKELQSYGRERSFDSKRPRRRRHSDEVTQRRSPIKDVCDGERERRLSQHGRASASSRVSPVGRNRRYSEDSDVLDDEHRMHSHRSLSDEASPRHRWRLRCDSEARRPPPLCADPARFHHISFSSSYTDNDAYATAAVTGAERSCSRSERRRSGRNRGDVKDQYGSAAGQRVRFAVTSSLIGGDAEKKEELLESSHFNEGRRGNSRYHEEAGRSPRSKARHTRSKSVQATGDGEHLRYDCEDRRGSRVRGGGWVDRCDGAGAYDNRRCGSALDYGDADSDASRRHNSPDGDGCGGLGRSQRYRTPPVAASPTRKSPLRSRCGMYPLDLAVGVQPGRTRYKSLTSPVSSPVRGRQALSAASVKRTTPLQRASQSRVSSTTSAQLSEKELLAEVESKLGALEQQIADDDAEREHAMRRSPFERLYHLNNRRERDERRNKVFQLNLLERIRERILSGSLEEEIARKEERLRKQKEMLTSPDGVFVRLYQNASPCRSSTNIAAAAAEDSGSKSAQDGNGGSRANVNTTGVSSRPASTTRSRMSKTESQALSNRLYASATATKQKKEDMAKRFLEERRHREVEELLIARLAGKIQLDRTRERASANRRLQTPAQLEEEARTQLKKLREEDPNGYEKKLLRGPVLSQEEWDMQAARLWKHGYVSKEKLEAQRKVLELKSCTFHPLIKTLPGSEAVAKRDHTHGNGSKGKNSDERSYGSADGAQDHCKADRCMELYHRGMQAKERGEALRDEHDREARLRILRSRMACDHHFRRRVELDPSLAERFIKSLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S235</accession>
    <name>A0A088S235_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_351240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703061.1">
        <property type="nucleotide sequence ID" value="XM_010704759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S235"/>
    <dbReference type="GeneID" id="22579153"/>
    <dbReference type="KEGG" id="lpan:LPMP_351240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350018000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_351240"/>
    <dbReference type="eggNOG" id="ENOG502SH0C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="239778at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="119" mass="12557" checksum="421CC1E4CC7B3D40" modified="2014-11-26" version="1">MLNERSETDAAAAAFLASVSLDATGGSAGAHGAFSTSAAPLSETQSTQSPVFRRSSSTSTVSGLPHTHSSRLGSKECAFVYRAPTYFDGVAVAFLGSVLDCYLPQKPVQKYYNMRVGIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S256</accession>
    <name>A0A088S256_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="12">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_051150</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="12"/>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="AIN95556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703878.1">
        <property type="nucleotide sequence ID" value="XM_010705576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S256"/>
    <dbReference type="GeneID" id="22572193"/>
    <dbReference type="KEGG" id="lpan:LPMP_051150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_050015900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_051150"/>
    <dbReference type="eggNOG" id="KOG3071">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF133">
        <property type="entry name" value="ELONGATION OF FATTY ACIDS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIN95556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="249" mass="29050" checksum="D291D91A1E919FDB" modified="2014-11-26" version="1">MKLADASQCIGKKSLCFHAELNTFVAYPGLIVSHIGYLVVVILLYKFMAGRTAYLLKYPMILYNMTQVVLSLTMAINLGQFLGYGVFNLNGHFTSTIEYWIFIHYLTKFLDMFDTYFMLLRKKEEQLTFLHIYHHLTIGFIWGLLLQHGVANGTAFFGAWINSAVHALMYFHYLYTSLGYKNPLKKYLTQIQMIQFVLCILHAVLVVVLDLHIPKKWAVLQLCYHMTLLYLFMQFYQKGMRKLKHKAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S298</accession>
    <name>A0A088S298_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cullin neddylation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_352470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703184.1">
        <property type="nucleotide sequence ID" value="XM_010704882.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22579276"/>
    <dbReference type="KEGG" id="lpan:LPMP_352470"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350031300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_352470"/>
    <dbReference type="eggNOG" id="ENOG502SJQQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cullin neddylation" evidence="2">
        <location>
            <begin position="1840"/>
            <end position="1907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="769"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1138"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1358"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1473"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1588"/>
            <end position="1630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="511"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="779"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="794"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="817"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1138"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1589"/>
            <end position="1603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO02384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1911" mass="206975" checksum="1CFB40136266C2CA" modified="2014-11-26" version="1">MTVSLHDLIKEWEVVNEELYRASQESHKRYPFPGSSYSCSDDSDRVGEDPSSTSPLPFSTTTYARVYSLLSRMRHIAEDPCYNSFYIIQHLLWVTIVAWANQMASMSDNFIRLPIGMRQYHESSSPCTTRSGGSKHGDKNDDTAKPAPSASTPLQRTSFPCALLQPLEFWDPSVLGEMTDTSCCKPDSLHDASLHRAPNLPEVWSNAVQRIFALWCSTPTAGSRSKSAQTCDMQSARGTAAPTTLQYAHIWVIVAQHYHRFKSLLSLFFLRYDVLLEDAEEQRPQEGGYRSGLPDGQAQRAETNAPLPASLLLRRRGGISRGSSFSISPGDAASATEVDSRNSSTSTPAAPSADDKVTQHVYKQARVSSRLPSSSLSTANLLGHLMRSIANENLSKIYEVTREAILSLLLPRVHRARLRHQSTIPASGSGCSSQLPHCALPQDNTAMGEADTAKEASSALTTAQPPAGVPNWHSDEHDEDHEDDDLVVWSSPPSPLLAYTAASFGHDNGDAPAPAQRAGASATTSREGKRVQHEEYVIRSIFKLLLMIEDCRVHALQRWLVESSKRVAFFYGSQLAMNLFDDATPQPAAFAHDPSPCDPSVTTITTTRTLADANRVLRETLQAYVRLRAKLLFLNAGTTHFLDALTPWGRTRMLESLNAFLCGFCGVILPSDGKAPNKTTALPSNQQPNQAAASPVSGCNESVPFTPMNTAVADFAQKWGVPLWVAMCSDAQQRMEALRHVKEERSNRPKNSMALAESEYGHVMQPAKYQQQQRATEGWSDKEMGENDHWSGGPDNTGTSSAPVTSSLIAAAVSAGDDSHADKPDTHDRHSVASTELEDAVSHTTSVAWPPRSPTVANGCRDGSSDNGMHRHGGVEETGRALTRRRGRGLDLKRVLHQQQQRRARLGDVKLPQRGITASRSGAPVASSEDGGEVVESLYTGETTSAEEDGSLFAAAMGTGNDGSTISQLRHDTSAAATGERQRGGGQDITTAAGFPMKRFSRSAELHQVATLPDEGFPCLLYLMPRRSRFVILDKAAAAVQQQLFTCFSANVQAYLTDYLAECETAAAAAAADQRAALASQKKKRERAAHVTTMGGIASCTNAAAATPVDIVRPFPHPVLARMTFLLEMTYAALHGRDGATSDSRDDHTEGNNGSGDGGSRPPLMETGLTATGQELGAAFLEQCNGEFDSVVSTTLSAPKSPALLTIAAVRKGFQCFLTSLEKRASLTLAQALCGLVQQGATQQPPAAQLDAVDTILNMASLLNSKDMFVMLLKGYLAPQMMMCRSKSELVVELQVVDRMAYRLGAAVAAPCLTLLRDLQLAISDPRITIKPPPPSGARAGLAKGWKLNVAYESLSGGNRKGDGDEYRSASSGGVTEEYAQRAARRDSETLDAVHPSLHCTLGLIHHVRVLCRAWWQPHTAVLLTSRRLRQLWERHQLLDERVVDSVLSVEWKYDGHSEPFRGYGQLVRLREGEDNSHLRPPSLSDGGSAKSMWGSLSSDLEGDHSRCGNGGQNSGSLTAGTQLRTVTAAAVVRGFSSALGNAVRRTGRQAGDFGYHDSDNESEDYREAYGGLLTLSTLQQYRNAYAPSSSSYRGSNLSSIGSPGAGGEHWGASDGRQSTTADDRASTTVPADGQLVRRRLYWPLGDGQLVFYLFSKGAASAGHSVSQAVQILGPPLTYLICQLLDRASEQPYTFSALHGAFPVQVPKPLLAHILHELVKANVVVRSVAAGTRQLTYLLCDDTRKVRQRKVIVDVRAATQQQWVTQMMTMTGADAAGEGEDDNSERGSARDSAFLASPKEVTTAFSKLSPKPAPQVHLNASAEAEAAPNAAVDNLSSLTYSVDCTHKIKVCIVRIMKVERVLSHCELVEHVALALKGQLVVTPSQLKRCVTQLIEREFLQRGEQGEYIFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2P9</accession>
    <name>A0A088S2P9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acyl-CoA dehydrogenase, mitochondrial, putative</fullName>
            <ecNumber evidence="7">1.3.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_070500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.3.99.-" evidence="7"/>
    <dbReference type="EMBL" id="CP009376">
        <property type="protein sequence ID" value="AIN95736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704058.1">
        <property type="nucleotide sequence ID" value="XM_010705756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2P9"/>
    <dbReference type="GeneID" id="22572385"/>
    <dbReference type="KEGG" id="lpan:LPMP_070500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_070010100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_070500"/>
    <dbReference type="eggNOG" id="KOG0137">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2588832at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008470">
        <property type="term" value="F:3-methylbutanoyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000059">
        <property type="entry name" value="Acyl-CoA dehydrogenase, mitochondrial,putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000071">
        <property type="entry name" value="Acyl-CoA dehydrogenase, mitochondrial,putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000073">
        <property type="entry name" value="Putative acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049448">
        <property type="entry name" value="ACAD9/ACADV-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF35">
        <property type="entry name" value="DEHYDROGENASE, MITOCHONDRIAL, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21343">
        <property type="entry name" value="ACAD9-ACADV_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="5">
        <location>
            <begin position="59"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="ACAD9/ACADV-like C-terminal" evidence="6">
        <location>
            <begin position="408"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN95736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="519" mass="56220" checksum="855ABD5BF24D44BD" modified="2014-11-26" version="1">MRRIFSSAPRQYVRYASYMAGLFNFRVVSEELFPYPSRKLDSDESETVQTLIEQIRSSDKELNLAGARIATEYGGLGLGHTAHALICEEVGTSGDSKLLQTIQHCGFASYLLSTVGSKEVKGKYLTGMSDGTIMMGWATQEGCGSDISMITAKATITSTGMYVLTGSKQCKFAESATHYLVLAKTLTQTAAEAGPMEVSRNTFFIVEKSAKGVSVNGEIVNFEETPVADVVGVVGEGFKNRMITLFTEQYVYASTLLGILKRVVQELRGSVPEQWAADTVASCACAMYAIESALYALTANLDLPTEDSLLDAALVSVFVQSSTNRWLSILSTATPMNAILEKCFANARLMLSMMESIDFLYSSAVCCGVEDYGLVFQRTSTLQMVQLRTMRSIGMKDRVPVRELDCSAIDSAVVAFGNAVEAAFVRNGSQVPLQQLIINRLGEAVSLLYAASASASRAAMCQSKCLLTAKAEKELASTFIAMATNRAIQLSEESCNVGMTADDSYKRIAVEMCDEVLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2Q3</accession>
    <name>A0A088S2Q3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L7a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_070550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009376">
        <property type="protein sequence ID" value="AIN95741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704063.1">
        <property type="nucleotide sequence ID" value="XM_010705761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2Q3"/>
    <dbReference type="GeneID" id="22572390"/>
    <dbReference type="KEGG" id="lpan:LPMP_070550"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_070010700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_070550"/>
    <dbReference type="eggNOG" id="KOG3166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270219at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000036">
        <property type="entry name" value="Putative 60s ribosomal protein L7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001921">
        <property type="entry name" value="Ribosomal_eL8_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00882">
        <property type="entry name" value="RIBOSOMALL7A"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="6">
        <location>
            <begin position="132"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN95741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="264" mass="29852" checksum="108E5ED11EC26CAA" modified="2014-11-26" version="1">MPGKEAKRATQPVKAASPYKKPAAASRFTARPKNFGIGQDVPYSRDLSRFMRWPTFVTMQRKKRVLQRRLKVPPALNQFTKVLDRTSRNEVLRLIKKYAPETRKARRDRLHKAAEEKKKDPRKTVSTRAPLAVVTGLQEVTRAIEKKQARMVVIANNVDPVELVLWMPNLCRANNIPYAIVKDMARLGDAIGRKTATCVAITDVNAEEEAALKNLIRSVNARFLSRSDVIRRQWGGLQLSLRSRAELRKKHARNAGVDAAAVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2R0</accession>
    <name>A0A088S2R0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_342390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702665.1">
        <property type="nucleotide sequence ID" value="XM_010704363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2R0"/>
    <dbReference type="GeneID" id="22578744"/>
    <dbReference type="KEGG" id="lpan:LPMP_342390"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340029900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_342390"/>
    <dbReference type="eggNOG" id="ENOG502SKU3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266721at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="208" mass="22214" checksum="49AA6880EAFE675F" modified="2014-11-26" version="1">MFERTDSVLLYFTYAALMTALIVCSVLSPIQVRSVGERKLCAYGVAIVYDLPPSTWPVASDSPSAMSRNSSQPFEIARVSLSLAQLPSSTLTRCMTAYLSFAALCLLTCVSLLISLIVQVLPMKHDRAVIVVTRVFTVLVPLAAVLCFAMAAVLGLQAGLYHHVAAGYYSDTGSDNLVSKLRSGFFSSVAAAILGVSVALLSPVLSKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2T1</accession>
    <name>A0A088S2T1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Aminomethyltransferase</fullName>
            <ecNumber evidence="2 8">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 8">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">GCVT1</name>
        <name evidence="11" type="ORF">LPMP_353910</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[protein] + (6S)-5,6,7,8-tetrahydrofolate = N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the GcvT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="2 8"/>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703326.1">
        <property type="nucleotide sequence ID" value="XM_010705024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2T1"/>
    <dbReference type="GeneID" id="22579419"/>
    <dbReference type="KEGG" id="lpan:LPMP_353910"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350047100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_353910"/>
    <dbReference type="eggNOG" id="KOG2770">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10263536at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006546">
        <property type="term" value="P:glycine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.110:FF:000003">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1400:FF:000001">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.110">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1250.10">
        <property type="entry name" value="Aminomethyltransferase fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GcvT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001567">
        <property type="entry name" value="PRK00389.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF2">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006487">
        <property type="entry name" value="GcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="GCVT N-terminal" evidence="9">
        <location>
            <begin position="10"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="10">
        <location>
            <begin position="294"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006487-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIO02526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="377" mass="41538" checksum="C5814AD4DF03238C" modified="2014-11-26" version="1">MSSPLKRTALHSFHLAQQAKMEAFAGYHMPISYGKLGVLKEHLYTRQVAGIFDVSHMRQYEVRSTDREKFMEYVTPVDLQRTQVGQGTLTILTNAQGGIKDDCIVTKMDDHLLLVLNAGCKDKDVAHMEEVLDEGAMKGADVRLVPLERSLIALQGPQAAAILSEFMDGVPDMDFMHCRQKVKIKGMEVQVTRCGYTGEDGFEIAASDRDVVTLVELLLSRKAELIGLGARDSLRLEAGLGLYGHEMTEDINPVAARLMWTISKRRMEEGGFIGYEAIKNFRDNASKGAVPRLRVGLVSTGPVAREKTVIEVDGKQVGEVTSGCPSPCLKKNIALGYVDRGLAAKGVKVDLVVRGRRVPAEVVTPPFVPAHYYRKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2V0</accession>
    <name>A0A088S2V0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UBX domain-containing protein 11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Socius</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">UBX domain-containing protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_355570</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May be involved in the reorganization of actin cytoskeleton mediated by RND1, RND2 and RND3. Promotes RHOA activation mediated by GNA12 and GNA13.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with GNA12, GNA13, RND1, RND2 and RND3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703488.1">
        <property type="nucleotide sequence ID" value="XM_010705186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2V0"/>
    <dbReference type="GeneID" id="22579585"/>
    <dbReference type="KEGG" id="lpan:LPMP_355570"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350064400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_355570"/>
    <dbReference type="eggNOG" id="KOG2086">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25887at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.210:FF:000003">
        <property type="entry name" value="UBX domain protein 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.210">
        <property type="entry name" value="SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036241">
        <property type="entry name" value="NSFL1C_SEP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012989">
        <property type="entry name" value="SEP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333">
        <property type="entry name" value="UBX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333:SF4">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08059">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102848">
        <property type="entry name" value="NSFL1 (p97 ATPase) cofactor p47, SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51399">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEP" evidence="12">
        <location>
            <begin position="321"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="11">
        <location>
            <begin position="533"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="169"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="223"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00059434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00062345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00075811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIO02688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="608" mass="66289" checksum="5F2857524A83B38E" modified="2014-11-26" version="1">MDNGRRRGSKPPGSPQLFRANPPKKGGDPSDALLLSPDVLDDATRRELLQDVLRQRRASLSPVGRLSGPGAVAGDVHTDKEPFAHQLRARVRAGSSANSDNLVTAMAARLKDLESKQKAYQAELQELHAKYRQLNDNYHRERELREEAETAVLTLYDEKELLEAQLREKEAAHARASNATNNHPPPPLNRVGKVTHSTQASPSHAPVTPLRAVKVDLFSGNFKDHHSDDGAKATGKAGPTHRVDTGRPDTVHLTPQRVGGLPDNRNAASAVAGSSPKPPHSRHSVGTVDVELLTKNARILSDYVGWKGVVREGNQAGIRERDAVRVVVYKNGICVNQGPFRPYGWALCDAFLDDLIEGFYPYEFKERYPDGFPIEVVDRTSETCETHRIGAAHGSGVASLENAGPLFPKEGGRRLGGARPNSGRNPHRVHTLDEQKKNIDYAPVSAEEFLKKVPAQTMTAGGQLVSVRNDVAALMGVAATSSSASQVSRTIKHVSAAEVAYCRKVTQQQRSSSLVNAATVAASSMFVGNLIAVLIRLPNGQKIKLHMAPEDTVAALRKEFVAAAPNFQTVRYELYQAFPLKQEWNDHQLTFASLGVKKSCTLMVKLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3C4</accession>
    <name>A0A088S3C4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flagellum targeting protein kharon1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_356000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703529.1">
        <property type="nucleotide sequence ID" value="XM_010705227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3C4"/>
    <dbReference type="GeneID" id="22579628"/>
    <dbReference type="KEGG" id="lpan:LPMP_356000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350068400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_356000"/>
    <dbReference type="eggNOG" id="ENOG502S730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272006at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="407"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="515" mass="57674" checksum="A400D0B303D656B4" modified="2014-11-26" version="1">MTQEVSPQQNTESEYMSARQRAKKCRSGENAARLLMGLDLEMDDAERRKHAGRCHNNAPRNSFSSPREFFAGPTKPPHRCSGIRHNPDGNRDSVGFMLKDEYFMMNPEIDKFQSRRVRARMMRNGSPCRYGSISGMGAYGIQARRGEGSLRQNKTLKMARMNGSPWGTGSYHCRDGLTNNCIVTAPEVPWRCGVRITHPQGAMEAPYFEDNDPRPPRDVPAVTGKRHVKPPYKDAKMFGQVPPPAEGEEDEFHSILPPCHKTSNKANESVDVLNLYCYTADELNEKPQPYKQLGPRKCDAPELPPKKPPVIKHIDTPARKEHDVLGTGRWGFPEKQVPRGLARGLCRPRHDTANLFYGGPAQEDDKLASGTPRESAGRNGGSNGAHLSPRQSHQGESHRSASRRSSSHGSRTSARPSRQVQPFRAHRNTPPKKREDPVFESNFRPHKVVFKNVGNPNLLRYYDPTVDPMPEAMGPKRSAPRSNIESMLDDSNMPCAFGKGRGEFNKHSRSTITLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S4K4</accession>
    <name>A0A088S4K4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_120890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009381">
        <property type="protein sequence ID" value="AIN96416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697069.1">
        <property type="nucleotide sequence ID" value="XM_010698767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S4K4"/>
    <dbReference type="GeneID" id="22573095"/>
    <dbReference type="KEGG" id="lpan:LPMP_120890"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_120013800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_120890"/>
    <dbReference type="eggNOG" id="ENOG502SHQ0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267782at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="580"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="695"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="852"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="415"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="700"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="883" mass="90605" checksum="CA5FCA25DA01BBE3" modified="2014-11-26" version="1">MPPSWLPSRSSSCCSATSSSFISGTDCSSCPPDNTNLVADGPGALKSGHHQERRHRHHRHNPPLHCSGDRHVAHGCAVNDPFTTAPRRVQTSEHTRFTSILASGGRCGESAESGAAPAGPRGRVDGGSSRIQDVAWWRSSTVAANITIGAVPPASCDVHPYYALPSPTSPLPHKQRGADFYRGCRDVAAAQRYSTPSPLLTTASGTLIVSPTPLPPTHPRRSSSAQSRTSNTVSTHTSGGTAHTSKLLFASKGGGGNRGLVRHAETDGGVPLQPSCSACCVARPTRCKTLRRSFSFTSGVPSATTPGYEALPLSLHRAASPLSSVNAATGALRTLLTGERQHERTASLASSVHSASSSVRPSVPLPPSHVGLASNMMAAMWVDLPLSQTGSRCATPLNNNGDAYPPPRRRRTTPRRCSGPPSPGTSTLAASVASSFDGGGYMSSVAGGASGSTRRTLVTVGTQTESDAGTAKGGGTPPSLSRRLYSRSLSGSYATDVSGGRHYSDAAHQYNFDCPLESEVVAAITATSVSSTSAEVSPRSLLASAAEMHLDNVVDHAALGAEAVGRVQQHIAVGDVVATAPHAPESLPTEATTKADDPSEGGSPSNAPAKLPGTTYVYQTLRVDAPPLRGGTKMAAVSVSAPGSSAAEMWSPERALMFPTTPSLPTLHVPLQTGSVLAASLQPQEGVLPAVGIPSPTPKASSSAEVAGESSLTTGGGEGYHGAVKGMTSVGCGATASLAKDGGPSAPQPVATSASDDVWRLRAELAEMRLQYEHVVQQLRHMQERSVASGSANPSIAVAALEAGHPTAKEAVLSTTSTSLPAGSASSCLSSVFIPNHSGMAESPAVDSASFVSSSSEGNATDAATTLDHVREALQRTRKRTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S4N7</accession>
    <name>A0A088S4N7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl- CoA synthetase, putative</fullName>
            <ecNumber evidence="4">6.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_130310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.2.1.3" evidence="4"/>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697114.1">
        <property type="nucleotide sequence ID" value="XM_010698812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S4N7"/>
    <dbReference type="GeneID" id="22573141"/>
    <dbReference type="KEGG" id="lpan:LPMP_130310"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130007300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_130310"/>
    <dbReference type="eggNOG" id="KOG1256">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF33">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="86"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN96461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="669" mass="74331" checksum="01D945D2F90F9F5D" modified="2014-11-26" version="1">MLQRFSRRSLRGYRGAQQVAALRCSLRFGMNVGGSYYQESDTAGIHQMNNDLRLGLVIKPQSTLVELWEQALKAWPTRRFLGSKMWVRGKLGYVWATYESINTEVEAMRTLLHKMGVEKGSRVVVISENRYEWVVVHFATMQLGAHFVALPTNITPSEAQLVVRSTQSKVLFVETKASYAAVKGWIGRVGQLEHAICFEDQVGEGSYAVAISIAADVPEKTPARTDVRAEDTAMIVFTAGTTGPPKGVMLSHKNIVANVSSVYASLGEALTHSDMFMSLCSWCVAGTLTADLYQALCKGACVCIPPETLEGFQDLPLVNPSVIVSVAQPFQRAYANIVDDILNRGSFTKDLTRLVVGRITENRLMFKKPGRTLRAFSHALLGKFKAQFGSELRVVIIIGHQLTKDQSELMADLDVFVVNTYGCMEAGGLIATDVDVPQRLKALPGLEVRVVNEKNEIVAPGDLGEILVEAPNAMQGYFDVHIDPEEAKNSLVEYGSRTFVRSGDYGTLTGGWITVRGNKDVLIKLANAKTVNPLEVEATLTKSPFIKQVFIYGNGRPYVVALVVANTKAIAAHLRKVERRDGMPLVNDREKADCIRAELRRVSQDLPPRTHVRRFAFVDEFTLANGFMTVKMGYARQKIEDHYVHYFEALYDETPKFYGFAVDDYDDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S4Q7</accession>
    <name>A0A088S4Q7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase M24-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_130570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697139.1">
        <property type="nucleotide sequence ID" value="XM_010698837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S4Q7"/>
    <dbReference type="GeneID" id="22573167"/>
    <dbReference type="KEGG" id="lpan:LPMP_130570"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130009900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_130570"/>
    <dbReference type="eggNOG" id="KOG2776">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5876363at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd01089">
        <property type="entry name" value="PA2G4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047113">
        <property type="entry name" value="PA2G4/ARX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804:SF11">
        <property type="entry name" value="PROLIFERATION-ASSOCIATED PROTEIN 2G4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804">
        <property type="entry name" value="PROTEASE FAMILY M24 METHIONYL AMINOPEPTIDASE, AMINOPEPTIDASE P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="4">
        <location>
            <begin position="156"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="272"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="549"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="560"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN96486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="569" mass="61267" checksum="22BC8A0DA0A27CA7" modified="2014-11-26" version="1">MGRGYSATRSKSGRPTLRMKRSRSMSLHALKKNMNAREAVKAGHNGSAEASSSSSDAAAEVSRKTLKVMRQRRAPSLSLAVTGTTTVAAKATTTGAATKKKSVDGRRCTAIRSAGTRSQSTAFRRNLEDLEKQFNDAMEASEDEEETVMNATTMTKYKECGRVVDAVLDQLAAACVPGANTKTLCDAGDEEIASRLKGLFVKTKDAAGKRLARGISYPTNVSVNEILCNDSPYRVEDGTILKDGDVVKLHVGCHLDGYPVSAARTVVVTTRAAPTAMESDEEEAPKKSSGMTGMSSSRTAAGNVIEAARVALLAMIHALRPGALNADITDLIAAVGHHYGVQAVEGVLSSRSKRWVPDSIDCIIARRVTSRDPHQDVGDCEVDAHQVWCLDVAFTNYDSYRITLAEKPVTMFRRTPADFAADARVKQANETLQEITNAHFCFPFHFKSLANPLKGRLGIHVLQKAGVVDKLPPLRTKHGYVTARFSATVAVTAKRVTMLCGAPPTAPVGMPPAMRPTISEDTLAAEVLALLRRPYEFADVRAAVMAKGTKDQSSPATKRMRVEAMESEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S4Y5</accession>
    <name>A0A088S4Y5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Adiponectin receptor protein 1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_355640</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703495.1">
        <property type="nucleotide sequence ID" value="XM_010705193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S4Y5"/>
    <dbReference type="GeneID" id="22579592"/>
    <dbReference type="KEGG" id="lpan:LPMP_355640"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000019200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_355640"/>
    <dbReference type="eggNOG" id="KOG0748">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="529367at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF52">
        <property type="entry name" value="ADIPONECTIN RECEPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="480"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="161"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIO02695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="511" mass="56975" checksum="2D816A8E7AF97A4B" modified="2014-11-26" version="1">MSLKATDITVGDRALHRPLCKLSKEDSRVLLKSQESNESLPLDSKTAIPSAHMPPMCATRTCPTHASEKPHNRTKSGERALVDFLAHSLTEVVAPPFIPTEREHNFFMSNADNQCSGDSSTQMIVRLGLDNAQTSTDPFDAVIVHRIIETEDVGISVAGTQDTTGVSSAAPSIAPDSRGTPLHQEQLAPDAKTPEHGYRRNKRRLSLAATAPPFDTTREQQWNLINRGRDQTLPLYKFEEVPPWQKHNSYIGSRYRAFYTAQMCFKSLFGWHNETINVYSHVLTFLAFLVFTALLYTTVLSKAITAPSLSASKLVYGIFCFGSLMCMLNSSIYHLFNSHCSCRVITAMGRLDYIGITVLIVSSFLPPLYVMFHCNPVARTVYITAILVLGTVGIIGPWTDVFYEHRWVRVSVFLGLGFSGLAPALHSLTIMPMNAVSTPTFLGILLMVLLYCSGVAFYVTKFPESRYPGHFDCWLSSHQLWHFFVSMGALVHYFNCVSMYQLWQVSDGMCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S5B8</accession>
    <name>A0A088S5B8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA uridylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">3'TUTASE</name>
        <name evidence="11" type="ORF">LPMP_140930</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>RNA(n) + UTP = RNA(n)-3'-uridine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14785"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17348"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173116"/>
            <dbReference type="EC" id="2.7.7.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="2.7.7.52" evidence="3"/>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697324.1">
        <property type="nucleotide sequence ID" value="XM_010699022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S5B8"/>
    <dbReference type="GeneID" id="22573360"/>
    <dbReference type="KEGG" id="lpan:LPMP_140930"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140014500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_140930"/>
    <dbReference type="eggNOG" id="KOG2277">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2274644at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050265">
        <property type="term" value="F:RNA uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF98">
        <property type="entry name" value="RNA EDITING 3' TERMINAL URIDYLYL TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="10">
        <location>
            <begin position="293"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="9">
        <location>
            <begin position="653"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="721"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1039"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="18"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN96671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1114" mass="119973" checksum="9D352796CB1BDA4C" modified="2014-11-26" version="1">MSKYSLLFHQSMADGAEASSSSSSSSGSSASTSNTNVSNSVTSDSTASSPSTVTPARRRLIHRRRDGIGAAEASSVAPPQPPRQEEQENLISDPVRRGSSSSISVSESNAPATAGSDYIASVASASALEVLSAPVASAPPSWQGTAAPESDGDVVVVDDIIQSQEGSSNDRASAVSGAATEHTLRIDGDSALNKGDPGALPPAASSLSVFQHTPPRLFTCDMCLHYVSTSYEALEQHALDQHSDALADYTRLRTVARKLVPVWGDVLKRKASVVQQWGVKIFAVAVQRDAGAEKMAEAHRARAQLELVVQHWHPRAKVFIFGSSVAFGVWDGISDIDFTVVDVEELEAGTWPPSEKNAVRSITELLRRAGFSFINLEPISHARVPIIKHHASLPIRLTDEQRHRLHEEARQSAAAVNSAAPELLASSSPSSAQQEAPAEKGHTQLEAELIIARSVRYSLNLPAGPPDSAILEASIRLAVGSAALQQVWWNRTRDMCCMTFDTTTSAVKASTCPLHFISAGMRARVQPLHEECRPELYGMDFDLSFRAFGIRNSHLLRRYLLSHPCARPGALVLKDWSKTSGVNNSVNGYLTSYAINIMWIYYLVHRGVIPYVCPARDIPASLRHNVDPDPQYAAMVDPAWTPEERAAMEAQAGELLLGFFYYYAFEFDWANHVVSLNRPGVTTKAALGWDVEDVAPVGGLVPHFGAAGSQHQHNLTGAEIHHSDIHGGGTPAASPTRSPAGRDGMIASNASMAARRSRATTRYSFCIEDPYEENLNLGRHMGVTKTLRVQTELYRGLLSLLKDDLQHCCVFAASANTSGNSGNADNSGVTVSGAPATAAATATNASGEPMELPVRVLYKLMALSTRELAMARRRHSAAVTTGVEFPGVPFSDLKDAFLAQAPTEWKLASQVWNRDQLLHRLGLKLHAREYVLPRREVGVRRLAAKAPPGVVLASTPEPTFTAATAEGRQASFSPEHAPSSSAEVKEMNRAFLGAVPTRRLPEDLLLAMTRGYSCLTPSWVAWTKPWAALSAWWTDRLRSPSTAPESEDSLVSGEPAHEGVDPSLPPGAPPHVSAVPGQAAGPIHQTRTQLRQHVVAEAASVATGRRALRMLFHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S6A9</accession>
    <name>A0A088S6A9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_170580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697749.1">
        <property type="nucleotide sequence ID" value="XM_010699447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S6A9"/>
    <dbReference type="GeneID" id="22573801"/>
    <dbReference type="KEGG" id="lpan:LPMP_170580"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170011400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_170580"/>
    <dbReference type="eggNOG" id="KOG0817">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000010">
        <property type="entry name" value="Acyl-CoA-binding domain-containing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF115">
        <property type="entry name" value="ACB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="2">
        <location>
            <begin position="2"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="103" mass="11399" checksum="0C78A64D76B9E893" modified="2014-11-26" version="1">MSDSDFDAAVLYVRSLPKDGPVQLDNDSKLKFYSLYKQGTEGDVKGAQPWAVQVEARAKWDAWNSCKGMSSQDAKAAYVKLLATVLRSRGVQWRSGAKVQSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SBE4</accession>
    <name>A0A088SBE4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosome biogenesis protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_251230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699693.1">
        <property type="nucleotide sequence ID" value="XM_010701391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SBE4"/>
    <dbReference type="GeneID" id="22575771"/>
    <dbReference type="KEGG" id="lpan:LPMP_251230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250018000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_251230"/>
    <dbReference type="eggNOG" id="ENOG502RR43">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266764at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046351">
        <property type="entry name" value="UTP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1066" mass="113147" checksum="D828D2B3F3E0DE88" modified="2014-11-26" version="1">MPPKKTKRSAATTAASPAVEQMPTKRTAASPVKPPTTLCPQPQSSATSIKRSSAVGNADLALSSSFTPQRQRKESLPQPQLRTPEVERSQSTPKQVRESSFGASPQAIPPAPATSPAPASSKTPRRSSSSSPTQRSPSEKVSKSKANSTTAAATAATPHVSPAHPSSPPSPASHERTTSLQPPQSANSMKRSARGAQGRSISVDTTPTSTVPAKEAPAAAAAGSANVGAIVGAAAAGAVKSSKSARNRSERRSRARAAFLAATLATSSPDARFVERFIRESKVIAPDVSGIRCLAVHPSEQELIAARENGSLVRYTVTFFQGIPQFVQRRHTGGQTHRTISGLAYVTVPTPLSSSSSASSPGAASAPRHVLLASMMSGQIVIYDAELLVPVALHQRSGGAIWALHVVSAACIYAAMADGSWQQLRLTCKRDGAAPQLELVRVVPSISGADRALSVTTSLSLRMAVGSDDAGNVHAWRLPVYVLPQGSSAGAGAVEEEDEAAAPNRARGLAEHESMWTTRLAKGIALSCAVVGGVQRPCVVVGTSMGDVVLLDAAHGHVFQTFSQHKGPVSTLAVKNDAVVYASGWHESLRCYRCNEKGDWYPAEVKRRTHYHEASQLALLPRHQLILSASRDGTIMYAPTGQLFTSPAMYVTVTTQQFAYAADRELLLQSRFDTIEAFHMDGAARHWVPFFGHRLDGRFHLSGLWCDRQLNYIVFSTEERVGLLKVVWRAHAAMSVSRLEAVLELSARSGVVDVCWSGTAVAVGSAEEMSADASQEAATDTSALSPAPQRLYILYDKSVTFVALTDGYPVVHTPVQVRGRLLPGDSLGLYRVLCRPAAAAPLARNRRSGSIVDATEGEELVIYGHRGSCRMRLMADGTPDADSLVADLDDVYELAQELPLLQDASNAKAKGGSHGGAERALKRAKAEALASSALAKATSCEALVGLSAAQQRYVVGPTLHSSSAATTPLSATLPHDVRWITRIAASSSNNSTTVTSSAAASSYKYLGYFSRGLLIATGDSWHMVRRMNVEAAFLVKDSTEVLVLERNLEKTLEALPLCWKVRRFGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SDP6</accession>
    <name>A0A088SDP6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_282480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700588.1">
        <property type="nucleotide sequence ID" value="XM_010702286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SDP6"/>
    <dbReference type="GeneID" id="22576693"/>
    <dbReference type="KEGG" id="lpan:LPMP_282480"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280031300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_282480"/>
    <dbReference type="eggNOG" id="ENOG502RXXT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275909at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="286" mass="32347" checksum="436A9A2E09EC72B1" modified="2014-11-26" version="1">MLRFTVPALVVFQNAYAPRVLNKMTPDRMELTMIILKERKKRVRYLGSQFHGFADRVHLFNARGGVRRGTRYIIETHHSRVEFRHPARNNKKVDVRAVKIAGAQYDSIGNFTRMTWDNSLCTTNLLSDPNFKRHFKSMPKDEAIAMLEEWGVRYVLLDEIRKPSLMDCKYHKHHLYADKFWWSPYPEINHMRGDAEYKWKGDELIAYSDYNAHVQHPGNFGGSSSSSGRSGSGATTPKSAAAASGSKKGVSASPWFRCTVVVKKPQAGGVKANSTTGKIVTVEAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SG38</accession>
    <name>A0A088SG38_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription like protein nupm1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_311810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701572.1">
        <property type="nucleotide sequence ID" value="XM_010703270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SG38"/>
    <dbReference type="GeneID" id="22577607"/>
    <dbReference type="KEGG" id="lpan:LPMP_311810"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310025000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_311810"/>
    <dbReference type="eggNOG" id="ENOG502SHHW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267519at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="459" mass="50591" checksum="9B4BF038A2FD609C" modified="2014-11-26" version="1">MDLSVTVSFIFIVSATVLGFAAMIALFVSMPFSCCKISNGDLADGNRDRQRAGAATGQLGSSSNGEGAASEREWRGIPLNSRPPRLTPEQEILRDKAMERYKRRKARQERRCQRQAAREARMANMREGYGEDTASEGEFADGSSVTSRTTLASAAPTARTASTVAYGRGSYFLPSPCACEGHIEEHDDSDDRRSSRSSGSRGSTGTARSRASQGTATTKSHMRHRQRQRLRRREQQQQVDLFNQWARMQMVPSSELSPSSKSLSASSQRDEEGSTTDEGGRRRTKAAFGSRYRVHTHRRRSSSVASSAPRPPEDVLGTGCSTYPFVMNAEHGHLESLRVGNQHPVSDKITVDADGSEYDTTPFCPFTHSNGATDSSSPHVSPADHLRYANRTGEQSGHLQPRRHKHTWKNVEHNVALSGFFNSPTNDNMAGADIQSRPHYNDGEPSHNPLGDHEHIFQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SH07</accession>
    <name>A0A088SH07_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">18S rRNA aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="6">2.5.1.157</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_322080</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an N(1)-methylpseudouridine in rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine in rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63296"/>
            <dbReference type="Rhea" id="RHEA-COMP:11634"/>
            <dbReference type="Rhea" id="RHEA-COMP:16310"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
            <dbReference type="EC" id="2.5.1.157"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TDD superfamily. TSR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.157" evidence="6"/>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701892.1">
        <property type="nucleotide sequence ID" value="XM_010703590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SH07"/>
    <dbReference type="GeneID" id="22577949"/>
    <dbReference type="KEGG" id="lpan:LPMP_322080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320026400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_322080"/>
    <dbReference type="eggNOG" id="KOG3154">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262062at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106388">
        <property type="term" value="F:rRNA small subunit aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01116">
        <property type="entry name" value="TSR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022968">
        <property type="entry name" value="Tsr3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007177">
        <property type="entry name" value="Tsr3_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002621">
        <property type="entry name" value="PRK02287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426:SF0">
        <property type="entry name" value="18S RRNA AMINOCARBOXYPROPYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN TSR3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04034">
        <property type="entry name" value="Ribo_biogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNase L inhibitor RLI-like possible metal-binding" evidence="9">
        <location>
            <begin position="43"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="16S/18S rRNA aminocarboxypropyltransferase Tsr3 C-terminal" evidence="8">
        <location>
            <begin position="81"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="236"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIO01092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="293" mass="31824" checksum="84AE9210904CCEF4" modified="2014-11-26" version="1">MGKSGARTRGGRPHGRGRGGSSGDACSTSGFHSNEPPAHPCSVPLAMWDFEQCDPNACSGKKLYRVNALRLLRLSEPFHGVVLTPSATDIVSPADRGIVLRSGVAVVDCSWKELDAVPWRKMRMSAPRLLPLLLAANPVNYGRPSKLNCAEALAATLVIVGLMDDARNIMAYFSWGGSFFDVNRELLAGYQQCANSAEISAFQNKYVETELLESEARRGLDLDAIDLSHAGPLNERRGRLKSRHEWQQPLRTEVDEDSEAGRKEGSNSHADTSDSEEEGSRSGSNSPAADRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SJC2</accession>
    <name>A0A088SJC2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_342960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702722.1">
        <property type="nucleotide sequence ID" value="XM_010704420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SJC2"/>
    <dbReference type="GeneID" id="22578801"/>
    <dbReference type="KEGG" id="lpan:LPMP_342960"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340035900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_342960"/>
    <dbReference type="eggNOG" id="ENOG502S2N5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273232at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="602" mass="65306" checksum="F8EACAE08F8E06FE" modified="2014-11-26" version="1">MEWRPNYRKAWVTGVVVVTALFALVVRRGQQKRRSAHQTTGDTTHDELAETLSHTVLPVLVRPEDLPAGWGVAPPVFYPPHCAAIPLVLPSEMHEVERHSCSARAGRTERSKQSKADNLAAKPTAFIFCSYAGCTKGLFTTQQDEEVLLAELLAHHPVLQKRLAENPGQWSPLPDAAPPAATDPESAAGTARERRQSSLPRTFSHVLVNDDYFILAGMNGPYIIIAVLGGFAGVFPSSLTARTPSRGEGSGRKRTGSATPATTAEGTGLSDVIEAIARATVSVPLVKLGNESSELASRTPGTSFAVHRGYYRVVYTREGQELELCVPSEWSVWSEYVTSSLTTPTDASSLDGKTVSTEEENAEPKEVTLTLSFTPSSFMSESRVEICVSAELFAALLENPQAAAATLWAASAATDVSNPVAKATLGVLTGRPLPASSHGRTNVVTTVYVQPKFGVLFSVHPRSAVVYEPWLTDLPTILYYPLGDAVEDEMAPRMTIEYVVEMPKTWEVLTSDDKEFLHNVLSHFTNGDVAAGSATLTEISGIGCAMFHETREGCRCRTYVLPRVATVLVIRWMTSVDSWDRDLPVFQQTLDTLHVDAAPISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SJZ8</accession>
    <name>A0A088SJZ8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.131</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ALG11</name>
        <name evidence="15" type="ORF">LPMP_345080</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + 2 GDP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:29523"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19516"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="ChEBI" id="CHEBI:132515"/>
            <dbReference type="EC" id="2.4.1.131"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:29524"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.131" evidence="3"/>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702927.1">
        <property type="nucleotide sequence ID" value="XM_010704625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SJZ8"/>
    <dbReference type="GeneID" id="22579013"/>
    <dbReference type="KEGG" id="lpan:LPMP_345080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340059000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_345080"/>
    <dbReference type="eggNOG" id="KOG1387">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2276068at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004377">
        <property type="term" value="F:GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000256">
        <property type="entry name" value="GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038013">
        <property type="entry name" value="ALG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031814">
        <property type="entry name" value="ALG11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919:SF1">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15924">
        <property type="entry name" value="ALG11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839537" description="GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase" evidence="12">
        <location>
            <begin position="25"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="ALG11 mannosyltransferase N-terminal" evidence="14">
        <location>
            <begin position="26"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="13">
        <location>
            <begin position="275"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF15924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AIO02127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="466" mass="52352" checksum="9645239BA9A98FC3" modified="2014-11-26" version="1">MLSIIALMLATLALLCRHRKRAYARNTVGFLHAAAGAGGGGERVLWVALDGLQHADAVKGVERQYVVYTNEYKPADRSSTESSDQHLLSLIESQFSIRLLRPVRFIYMRPALTRWLSGDAYPRLTLLLQTFCGGAALFYEVAVANAVTPIVVETVGVPFVYPLLRLLAGCTVISYTHYPIISSAMTQRVRSGEVSHTNSVTMAQYRLLRCAKVVYYEMFTLLYRCMGFFPNMVLTNSSWTQRHVQSLFWPRTCIRLYAPCDVARFAAGSRPPALRSNRIVSIGQFRPEKNHMLQLEAFHAAVPRLPRDAKLVMIGGVRNADDRKRVAQLNARAKELGVEKQVEIHVNAAVTEVWTELGSCVIGLHTMRDEHFGIVLLEYLAAGCIPLGHRSGGVELDIINSPDLGFLAVTAEEYTAAMIEICEMRLHDPERYVQFQRRGSEHVKSFDDSNFRTRFVELVSKYVYAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SK48</accession>
    <name>A0A088SK48_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ribonuclease</fullName>
            <ecNumber evidence="12">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">RNHII</name>
        <name evidence="14" type="ORF">LPMP_350330</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 12">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the RNase HII family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="12"/>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702972.1">
        <property type="nucleotide sequence ID" value="XM_010704670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SK48"/>
    <dbReference type="GeneID" id="22579062"/>
    <dbReference type="KEGG" id="lpan:LPMP_350330"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350008500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_350330"/>
    <dbReference type="eggNOG" id="ENOG502RS1D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7462577at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07182">
        <property type="entry name" value="RNase_HII_bacteria_HII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000193">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000194">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022898">
        <property type="entry name" value="RNase_HII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF23">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51975">
        <property type="entry name" value="RNASE_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11 12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11 12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-2" evidence="13">
        <location>
            <begin position="136"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIO02172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="477" mass="53586" checksum="C9AB76AB180E38E9" modified="2014-11-26" version="1">MLIMLNAWRFVPFVRRKSALGSGLLRPNRVLRQKRLTFPPFRPPPTWNALQKVVVGHRETDTGEPTLDGTLDLVGYQLSRDGLLPQTNISGRTLPAPDTNGISASTRRKLERERDAAVAQIKKYGVRLRRSIKETALTIGCDEAGRGPLAGPVVGAAVSRIPVSSFNNEFDQLYEAPEQFQIFDSKSVSERQRDLVFAMITGHVDFFDIASCKRFVVHHCAGDEAPASVLGSKKFDSHMKLSKLPFKKLLSMQTPYLVTYHGYNSAGNYVYFWSIGIANHTYIDEYNIYNASMNTMHRSAQSIWHMLNDARFSHETAPRPRSSSIVQYLFSRFCTAANHDNEKRYQVPHKLDLLKGATDYFDFEPIQPPLVLIDGHAVPGPSYDYFTSVSIGGDVQPIIEGDKRSLSIAAASCLAKVTRDELMNYIGALYPGYGFGENKGYPVEQHMKYVAKNGLCPIHRKTYRPCRAALEKSQQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SL60</accession>
    <name>A0A088SL60_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_354070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703342.1">
        <property type="nucleotide sequence ID" value="XM_010705040.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22579435"/>
    <dbReference type="KEGG" id="lpan:LPMP_354070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350048700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_354070"/>
    <dbReference type="eggNOG" id="ENOG502S3GZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="244005at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="962"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1111"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1180"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1271"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1393"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1461"/>
            <end position="1510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1111"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1126"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1278"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1405"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1474"/>
            <end position="1484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1510" mass="162177" checksum="D8DBF59447292F21" modified="2014-11-26" version="1">MASRERATQARHVMLLSNDAPVLNRCAKEEAHLKHRLAQSTAACALMTQRNHAAAAREERSRELRLQAQFAALLSGTRDIVVPSSSTVDLTDAAERDGGSAAATDRFKSHSTAATGAAVVSSPGLKSSSAVAATGSATPAASLLCALGFPDTYEASGFKSMIHWASVAYDETFLTAYGPRQIREVAQAQAIARAGGSSEAREAQPHRLMTAVACYLLNQVLCADAAVSELWQEKLRQPIFDAIFSSQPIAMGQEPGRAQRGGDVGDAAVVDAIVHRMIGPPSPLSCAATHSSVATSFPPRTNMYTTRDDFASLRLWTEEVTVEHREKVSLCHRIRSLQYAMARRQMAVHLFQRRAHHAELQVVFTVWCTHTKQRRANRTAIELYVVNRHHRYVTETIFLRWRRFTLRAKVEALQQRVLKIAADRECAAREHAAALQELQDQLATERRQHVQKTFERDTLHAQVLDSHALEVDALQLMLQMERVQAAQSSKWATRWERAAKTFRPAKPCPAVPRSMWMIARALLCSEEALAVMILNRSGAAQALLQIPYSVILQTRERLEQLLLMWVNAIMEVSPQASTWVTVEAFMYGHRSHLRGVLLSQKKSSRKVVAPRTGMTTGAAGKDGSTCEFSIYTLICLVRELRRCYIKAGLMESAEGWGTSGGSTVADCYQELTHLLVAQTCGGLYPPLLVHCSSSPLWFTPEGVFGEPASHLAGSKRQQRQQHTAFIWVLASLLVGHIQVMWMSPLGDREAQLGRSSKEGMETLRCKYEADMMKLAQVSFVLQHRAPPAGLGAAPRGTSVVAPNTLLPKKRAVASLVASFSAVAAAAARPEKDATVATEMTLEEMLRERCEVTRGSGCSNSCISVSGKDLLAVAEDSLSDIEAFLGMVPAQVQSLKLRAGANGSEDDYEVDEDVWVNGLLQQLFEVEGAESQLRRNMRLQSSEVIEDDATDGHARSAMTMPASAFGDDEESGGGWKGDDAATGEENARSTYRNLSKSTVALTREQLQLLRSLPGRSYGFDALRPIAIGPAQGASVTGEDLTDSSSTASYTSVAHLYSFLLNTLDDTVARQQWCGLARVVTSLAVRFHVLDDSEDAARQAVALAAVKDEYEELKSSRVVRESPERQTESPPSSSTSRLPPVSVGCSPGVPEAGKARTGAAGAASPARGGRVAVRLVPATLLQQPQPPSFPSTANVVPRRPPGAHSSPSVSIALNTGATPSQRAAEAGVSVVWTPPVHDLRGATATPAQALTATVSSIMLSEELHSRGAYQLNTTQDSLNGSSPVGSSAQGAPSSSPSHCAVPRIGAEAPVLMVPPPSAEVPTPVIPTAAPLPAQKDGRGVRDYAAESPEYIAGITSSGGSAFCPPMAGNAGTTAGTAYEARMHAPVEVLARERGAGLAPPQIPMPASSLSNARDPTPGTSSSLRPDNSCSTAIGSYSIPRQNATLQTPLPPTLRARAPPLLSAPTHALGHPPDPITVQSESSNSLSPLVIRHDPSQQLGSQRRRQYCFRMGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SLJ8</accession>
    <name>A0A088SLJ8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_355410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703472.1">
        <property type="nucleotide sequence ID" value="XM_010705170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SLJ8"/>
    <dbReference type="GeneID" id="22579569"/>
    <dbReference type="KEGG" id="lpan:LPMP_355410"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350062900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_355410"/>
    <dbReference type="eggNOG" id="ENOG502S63S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271880at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039963">
        <property type="entry name" value="Unchar_22kDa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38828">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38828:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO02672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="195" mass="22844" checksum="DAF3EEFA738AFEB4" modified="2014-11-26" version="1">MYTEGEQCAAVKRLTREELQRSVDRLSHSHRPEVELKPLVPRSTITKEALDKRIHHLYDESLERRQREREEVAQQVDAAIKRDATITVTKITPREEEALVCHLYDETLAMKKRNFDRLYEHETSHYERNTPKLTVKKQMSATDRLYREGMARERKKHIALYEKYVVGRHQPPLLRPAAELAASAEKMTRGEGVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SLX9</accession>
    <name>A0A088SLX9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-protein ligase, putative</fullName>
            <ecNumber evidence="3">6.3.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_356990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.2.-" evidence="3"/>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703627.1">
        <property type="nucleotide sequence ID" value="XM_010705325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SLX9"/>
    <dbReference type="GeneID" id="22579727"/>
    <dbReference type="KEGG" id="lpan:LPMP_356990"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350079700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_356990"/>
    <dbReference type="eggNOG" id="KOG2235">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10258297at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061666">
        <property type="term" value="F:UFM1 ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990592">
        <property type="term" value="P:protein K69-linked ufmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032434">
        <property type="term" value="P:regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018611">
        <property type="entry name" value="Ufl1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056579">
        <property type="entry name" value="Ufl1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31057">
        <property type="entry name" value="E3 UFM1-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31057:SF0">
        <property type="entry name" value="E3 UFM1-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09743">
        <property type="entry name" value="E3_UFM1_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="E3 UFM1-protein ligase 1-like N-terminal" evidence="2">
        <location>
            <begin position="5"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO02827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="737" mass="80662" checksum="0B8AD09A679EAED5" modified="2014-11-26" version="1">MEDVELSELVKRFQSLQRVQVSNQITERNAVEIVNALIQKKLIDLLFTTDAKEYLTWDELKCEIMDEVLANGGRLNVVDLPGLLNVHTFQVERVLPSVLAENPALTLEGGELMTDGYLDSVVLAAGDLLKEQGSLAISKFASVNQLSSLFAKSLLSKAMDRGRIDTLMQDGSLYTKQFVNRQRMIVRAGLLAAEEPVRLDAFYRRNKLFAPLLSHVVTEVRQELPGSFDGFSTYIPLVYEAKRTAEVENLYASNGYVEYAQLQRQGISNPRQYLTERYNPPDAAATEQAAGTTGPSSASAPAKQRKGRKKGQGSRVTAVAREAAVQVTVRACAEHPLCGYPLSNGFVSDRYLSNLPALQALVDRETLAVDVAEQLPLFVEVERDWPLLEERLCELYPGLESATLIANTILLSAAAEEAIKAALPPAVANARKSRVLVSTVVSDTIASVLKLSHDRYSEVLRELVDMWGEVVAALEQQLALSAANNVAAELKQLRSDLQEQLATRWIHLWVTAKGLEWALAQLDESTSSVIARHVMSTEAYEMARQVIRNESLDTQEWSEKVAAALEQVSQPAQLMKALVPFSESRRNTLIPLLDAVKGRSVGVFLDTLREMSGSGVVAVASFHSPNKKAERDAYAKIKESVAQEVAAASVSKKDPAANGKLLSLLCTLLVHQRFRCHVEVPGKAVAGVVGRLKSEAEVPSTLERAKDVVMTALQHGTVDEAGAATLEELRTAILTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4P8</accession>
    <name>A0AC62A4P8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NADH-dependent fumarate reductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3420080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="XUY36770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="514" mass="54161" checksum="7988375D676E3F95" modified="2026-01-28" version="1">MSDIASSLHRVVIIGSGLAGQCAAIEAARHGAKEVVIIEKETRLGGNSAKATSGINAWGTAVQKAAGVHDSGELFEKDTFASGKGGSCQPELVRTLSDHSAEAIEWLSSFGIPLTALTQLGGASRKRCHRAPDNPDGTPLPIGFTIVRALENYIRTNLSDIVRIETNARLISLMHSKEDDAVVVQGITYATQTASGEGKIRKLQARAVILATGGFSNDHTANSLLQQYAPQLSSFPTTNGVWATGDGVKAARELGVKLVDMDKVQLHPTGLLDPKDPSNRTKYLGPEALRGSGGVLLNKNGERFVNELDLRSVVSQAIIEQNNVYPGSGGSKFAYCVLNEAAAKLFGKNFLGFYWHRLGLFEKVEDVAGLAKLIGCPEENVTATLKEYKELSSKKLHACPLTNKNVFPCTLGTEGPYYVAFVTPSIHYTMGGCLISPSAEMQTIDDTGVTPVRRPILGLFGAGEVTGGVHGGNRLGGNSLLECVVFGRIAGARAAAILQEGGAGLPLQGGGQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5A0</accession>
    <name>A0AC62A5A0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucose transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3520320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="XUY36865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="560" mass="60527" checksum="CBECD9F89D6F9536" modified="2026-01-28" version="1">MSSKLQANDHPSDSISEKEPARDDLKKSIDDQSDAPPFLSASNAKVILVQAIGASLNGYSIGFVGVYATLFGYSTNCASFNSEQGCVTVPNADCKWFTNTNSTPFCGWTDITCRRTYTYTNLSDMPAAITQCEADPRCRWSYSSQECQNPVGFSSAESGIFAGSMIAGCLIGSMFAGPLASTIGARLSFLLVGLVGVVSSVLYHVSCAENEFWVLIVGRFVIGLFLGVIGVACPVYTDQNAHPKWKRTIGVMFQVFTTLGIFVAAAMGLALGQSISFDQNKDQMVMARMQGLCAFSTLFSLLTILLGIVMSESRAQFGGGEEGAIELDPNEYGYLEMIPRLLMGCVMAGTLQLTGINAVMNYAPTIMGSLGLAPLVGNFVVMLWNFVTTLASIPLSYVFTMRQLFLFGSIFTSCMCLFMCGIPVYPGVSKKLEVKNGVAITGILLFILGFEVCVGPCYYVLTQDMFPASFRPRGASVTQVVQFIFNLVINVCYPIATEGISGGPSGNQDKGQAVAFIFFGCLGIICFVIQVFFLHPWDDERDGKKKGSQLQEKEEIVDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5I8</accession>
    <name>A0AC62A5I8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histone H3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1620480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="XUY37059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="66" mass="7238" checksum="D87F239EB5F19D1A" modified="2026-01-28" version="1">MPCARCRACRRRGGPALPEQRDPGDPGGVRCVADGCHEPGQHPREACVTVRPKDVQLAVRLRGERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5S7</accession>
    <name>A0AC62A5S7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATG8/AUT7/APG8/PAZ2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ATG8B.2</name>
        <name evidence="1" type="ORF">LPMP_1920190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="XUY37140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="118" mass="12274" checksum="A4EBC961EE5BB0EB" modified="2026-01-28" version="1">MSAYQSSNTAEARRAECARLQAKYPGHVAMVVEAAKSSKAHLLALPRDATVAELEAAVRQALGISAAKVTLAVEGCTPAATAAVGDVADACKHADGFLYVSVRGEQAMGIFSLCFPFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5U5</accession>
    <name>A0AC62A5U5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phospholipid/glycerol acyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2920120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="XUY36946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="421" mass="47692" checksum="8E38B040C1AFA552" modified="2026-01-28" version="1">MQLHNRMAQYRPTKATGVITPYLVHGVAEQYLRIPCAVFMWCIFVCGALAPFLRSEDEEDVTSRRCILWHLLTWGHAYLCTNGLFIATAFLVENARCLVAPGPRRLSLADDYKEGNPAKVDKMAAFVYDTPPDTYERVKMFCFMVTGVAFVRVFTALASIFLGLFTASVAGYFDRYAHPWWFGFWSRVTAFITIVVFAVLGVYSVPQYGQFSSRSECKILIANHSCVMEVIWLYVMGGFPSFVSRKENLSFFFFGNVVRGSSSILVDRDVATSREQTMKSIMQRAGDPTAPQLMIFPEGTTGNQQALLMFKKGVFEASMPVQMVCIAFPYKHFNPAWLGRGAGGNSLCDILLRLSCQFVNYAEVRLLPVYYPTEEEKKDPKLYAGHCQRMIATVLREKISDASFGDYKEAFRRFAELKKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A630</accession>
    <name>A0AC62A630_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amastin-like surface protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2020840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="194" mass="22191" checksum="6A5C0B5FCE518DDD" modified="2026-01-28" version="1">MEFNPFIIVYAAIQFIAFLLVVVGTALDMFRLQSRENFEDRPCITLWGLKPYCNSIVYSLSSDERFSLCPVRRKRFHMAQILAVVSVGVYGTAFALGVIMLYCCLHLRWVCLLLNIVGFVILPIPLALMVLSYKTDENSLCPKLRDDYDFGVGFYIFATAVGMDFIDIVFLLIPWQYDYLDVTCNSKEGNSQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A679</accession>
    <name>A0AC62A679_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amastin-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0820190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="XUY37299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="211" mass="23556" checksum="6F07BAEAAA87A565" modified="2026-01-28" version="1">MEFTLALLLYAVLQLIAFLFVLVGTPIDMFHQRGGGRFENTPCITLWGSKDECHSGNYSTDLEELWRGCPARQHRFRACQAFAIISICVYGSAAVLGFLQLCCCSFPRWVCLALNVTGAVTLFIVWASMLVVYYQEDFLCVREKDLSVLGSGFALLVIAWLLDALNILFLLLLWPAADPSKSKDPSDNRDPSDSRDPSDNRDPSDSMDAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A682</accession>
    <name>A0AC62A682_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0820370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="XUY37317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="511" mass="54288" checksum="C609F36A22BFB3C7" modified="2026-01-28" version="1">MWRAEENIFARARPARLDTQYSSTSACTTAPPARPLVPLQWFHVPGRGARDAQVPPEGLVASTHLSTSSLLPPRSLSLGHCGAADASAHELGWDGREVDGDHWGIAGSPTVAQQPLPPASHGGAGTRDTCSLGSLLRHPHVRPTHDTSADDTSPAEVSRLLRYYRDENARLREQLKAKELHEAHIMERLEETSRMYAHVQLAWQRATRSDPPSSVLQSADDNVGSVLSVGSGGGRAEEAMQSRLAQKEAEVRELRGRVEAYREALQRSRAHAACSAEERQAAPAPAACSTGNGATVSVPPTSLHVLLLQSLNTADYLVKVFNALQHCHYTRHRGASDSASGCCRRSLHDCRLRCLQAAMKGAPITPELLELEDGPENDTAAANMEAAVAVREELSYCEAVAVRLAASLLGRERFADDDAAPPVSATGAAAPAQKAAPPASPSALEVAGPVGVAQAAAAAPRDDDDGEESAGEGERNAEESGHSAVSCAVAVREPRRRPSRCRPDVGDCEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6C1</accession>
    <name>A0AC62A6C1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histone H3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1020480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="XUY37382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="130" mass="14775" checksum="3B7AC1682C1CB152" modified="2026-01-28" version="1">MSRTKETARTKRSITAKKSKKAPSAVSGLKKVHRRWRPGTCAIREIRRYQKSTELLMQCAPFQRLVREVSSAQKEGLRFQSSAILAIQEATESYIVSLLADTNLACIHAKRVTIQPKDVQLAMRLRGDRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6C4</accession>
    <name>A0AC62A6C4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amastin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2020290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="218" mass="24213" checksum="9EFD9E76712432A0" modified="2026-01-28" version="1">MEWNIPILLYAIVQVIAFVLVLFGTPIDMYRFRPRYIRPNATVTTLWGVKKGAFNSTNLMTSDYLWRRCTGRRDRFRLAQAFAVISIFVYGAAAALGFIMLYCCSFFRMVCLALNIVGAVTLCIVWAAVAVTYHTYEGPDCWQESVFSTYGAGFVLLLLAWLLDLFNIVVLLLPISIAAGGAGGSSSKDSKKQDESSNDHSRESSMEGSRQNDLSEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6H6</accession>
    <name>A0AC62A6H6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Folate/biopterin transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1020040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="XUY37357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="699" mass="76160" checksum="CB8B3EFC2A9BA564" modified="2026-01-28" version="1">MSRKPPAESRKSHVTPDTEAAAAAVPVATVTENSGKYIHPEAASLFATCSWLRRVPIFGEAVEGYGPKVIVALGGCYLMCKGIADQILRGQTYAMMIDRYGIDVARYQRLSPISSMGWSIKAFTAMLCDGFAFLGYTKRWYMFVSCVAGGAFALIYGLLPAKESSANIACAFIFLSSWGKANVDILSQGHYSRLMRQNPQPGPAMVSWIWFWIMTGALVATIMNGPLADAGKPQISIFVSAALQLATCVFYVFNWYGEKKNRVLRSEDALYLLEETRRERARLGLEAGTDGQAGAAAKGKRSPQHSHSDEDVDAAVPGGLHDSRALVQDDYYDDDSEAVADGEAYYGKPPVPCLLGLFEVNTEVISKNWRIFVYSAVMTCAVIAMLCANILADTLGLLMACVVVSTICCATSFWALPLVIAKANVFGYLEKTVTIRVSSPINAFYLNSYHCPGNLPNFSYSFYNTVAGVITSVVGMITVALFNFLFAKHSYRLTFIVTTIMQVLGGVFDIIMVKRWNLYIGIPDHAMYLWGDAVVGELVYMLSFMPMIVLLSRLCPRGSESVVYALMAGFSNLGQTTAASLGAILMEYALPVFKRQDDGSRCNFDNLPVLLFVCNMCTPLLAIPLSMALLPKARICDDIDVDGRVVRQIVDRQAAAAGLCDSDSEKVAAAESSRDGKRGDGGAGHTEGEQSVHVRTPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6N9</accession>
    <name>A0AC62A6N9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0620010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="XUY37276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="663" mass="74164" checksum="4EE5CC86E2AEAB2E" modified="2026-01-28" version="1">MCNTAATREPVEDDYTHDSFSPIEVHEPHTPHLQHTPSHHHAFHDRGSFANLDSDTLNTGSVPDSYSLPLSWRKLSYSAGKKRILCGLTGTALPGRCLAILGSSGAGKTTFLNAISDRLASGGALRLSGRRQLGDCELERHFRKAMGFVTQDDIISPLSTPYDALWFSLRTRRGTGRAETEERVQEALDVLRLQHCRNTKVGIPGLEAGLSGGERKRCSIGIELICDPKVLLLDEPTSGLDSVTSAKVVHLLRQLSRMGRTVIYTIHQPTAEVLSYFDDVMLMTQGRIAYHGTMAASLDYFESIGFVCPSKYTPTDYYMTLLQDSATSKILIKRWSKYLKNGPRTPHSAAVRLAKSRRESSAARFLDAYIVKFGSSPVVQFYELTRRTLIEISRDSVYLFSYMAQAVFFAVVVGLIFLNLRANVEGIQDRQGLLFMIVMNRAMSSTFIMINTFNNVRAVYTREQQAGAYSPLMFFLGRSVAEFPVQILAVLVESCILYWMVGLHRAPGSFFYYCGVVALLSQVAAGLGFAISTACPSLMIGSAITPPILIPLALGGGLFASTDRLRPYWYWIEKPSFMRHTYILLMRNELYNVHNITCDNYRWGDEYCINQPRDGRTVLRLLQFDGDPQSESVYMWVSLLVLFFLLRIICVISLTIASRARTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6Q5</accession>
    <name>A0AC62A6Q5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Leishmanolysin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">GP63-29</name>
        <name evidence="1" type="ORF">LPMP_1020340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="XUY37376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="524" mass="55899" checksum="0A346B9472BF2C9C" modified="2026-01-28" version="1">MPPSAVSAVGLPYIALDAADTVARAADWGTLRIAVSTADLTDPDYHCTRVGQRVSNHADEIVTCTAEDVLTEEKRDILVSYLIPQALQLHAERLRVRQVQGTWKVTGMTGDVCGKFKVPEAHVTVGVSNADFVLYVASVPSEPGVLAWATTCQVFSDDHPAVGVVNIPAANIVSRYDQGATRTVTHEVAHALGFSSTFFKSTGVVMNVTGVRGKPFAAPVLNSSTVVAKAREQYGCPTLEYLEVEDQGGSGSAGSHLKGRNAKDELMAPASAAGYYTALTMAVFEDLGFYKADFAKVEVMPWGRNASCDFLTKKCMENNITQWPEMFCNTTERRYRCPTDRLGLGGCIVLTRTSVPQYFQYFTDPTLTGLSDFMDYCPTVVPYDDGSCAQRASETSPDMQAFNVFSDAARCLDGAFRPTATREDVTYAGMCANVKCDTAARTYSVQVRGSSGYVACTPGESVELATLSAAFVNGSYITCAPYVEVCQANVQGATSSGNAAAGRRGPRAAVTALLVAALLAIACA</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6Y1</accession>
    <name>A0AC62A6Y1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SLACS-associated protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0220160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009371">
        <property type="protein sequence ID" value="XUY37401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="825" mass="90094" checksum="612F29A886B4AA48" modified="2026-01-28" version="1">MYPDTAEQEEEDTGSAPRSAEPRTETHTPPTQPPGTEGEGEENDTAESANTEPDQTVEDVSQTSDEARHRFHHGENTAAQQTGTIHCPVCPRTWTSRARRQQQTSHLNTTHAREVVRVDALKATGVDRCLSCGEFVIASGNARRAHGQKCGEFVTRAVRNQKRARTEQSTPRQDAVAEPTPETPPPPTRHRTRPTEADAEWVQEFPATIRTLRKQEWGHWAEAVGHTLLGYTAAAAAGRYQRQLALTELVRTRLAKPRAPAREEDESHQEEPSETPREGGRDEPYTGHAGATRRANTEEHLPTRDAHTAEERRARRILHQLSLGAVGKAARTLFQAQLPRARASEALDQLRTLHPQEDPAGYPCPPQTPFPHGLKPEKVRNVVLKRLGRAAAPGLDGWTRELLVPVVENAALLAETTALMQDILAGNVSASFAFRLRACVVHPFLKEPGSPKVRPITPESVWLKIASHLALDAVEKPFRDIFQGWQFGVWGDAAEAVTQIRETYASESADTLVALDATNAYNRVSRAWVLRAAYRHHALHHTVGVVDLSLGEPGALGVYEGGRRVEQLWSTRGVRQGMVLSPLLFATAVAETLRPIMAAHPLAKVTAYLDDLTVVGPRAAVQAFLDEAGPALAATGFDINPAKSHHLSKSAAPEPVSVAGVVVPLARGVVRILGAGFRGSGAPVDEWVWEKTRPYEAYFTALGGDELPRHARMNLLRASALPRLTFLLRTHSTDELRDSAAWFDDRVLHTLSVLAGGAPIEDAAALLARLPLHGRMRAAVAAGYLALRGAKRRPERRAEGTHAPTGPTQPRGPQNTSSRSLPSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RH14</accession>
    <name>A0A088RH14_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rubicon Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_030270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009372">
        <property type="protein sequence ID" value="AIN95262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700970.1">
        <property type="nucleotide sequence ID" value="XM_010702668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RH14"/>
    <dbReference type="GeneID" id="22571893"/>
    <dbReference type="KEGG" id="lpan:LPMP_030270"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_030007600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_030270"/>
    <dbReference type="eggNOG" id="ENOG502SHR4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1918044at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052428">
        <property type="entry name" value="Autophagy_HostDef_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45971">
        <property type="entry name" value="PHOX (PX) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="990" mass="104413" checksum="B6491A777F6198D3" modified="2014-11-26" version="1">MHQAAGGQNGGKGYRDHDGQAADVVDAASSHPPPITNVCRTLEHIRAVLQQHQQWVSSTTVGEAGRAAADDGTSAHLATPMPHASNSYTDAECSTPQDAAKQQRERCRLLFLTEWAHRVAEAYTPITPAAAQAGTEHLTACPVPRCALAGDEVESAASPSKTLSTQAQRRPAEPSVAAAVSNAAPSGEAAASISGNKADLPPVREASVPVERRLNYSDGHRSAHAVMTASAPAIVESSRALLTATALSLSSPPPPIIPRDRAPLCRLVGVAFDVPTTRAAQCAVLAAQGSCCARCGVALPPPPFYFSEWCSALTRSLCAKLTCSCCHFHCCCGGCGGGQAITSLPCCRRLWHVCLCMARCRSSDEENERLTPVTAAHVTQEAISSIGSGRGGVRHNARAPLDAPENEDLSSNDGVAGDDDNNNNGSISSASERDSLLGDSTQSSRHNRTRAARRVTTRQPASEPAAYDYHRRDETGDGGGGSSADAAFLFCAYEGHYLCWRCFHSPLTGADPGTAMLAAAGSAIGGTLVSEGYQTRYITPEEWQARDADESPVRTALGRASGQLCEWWAARHVAQSTPVASALNATGSRDASGRADPPQQRIAAPLPLCVLPAHVLHRWDFTRFPVSAAAAAVLQRRFYLGNGNGQENCLAASVPTLERGGQRATAAGGSGYVSRINSEGLPILLSQEEQGARGYQSVPGIPPLRGLEGIPSRNRNTDGTTPPMTPLPQLYDVSAINPSLYVRVPALSAASRLRQQMSLLHAQAWWCPRYRHEVWGLRCGDELAGQVLEEVTAFPLSRQFPEPSPTVVNVAGRSSRSAEVVESAVDNVKAYLLTQDIAPPPFASAAASASRSHSVATPQAASLSAPCSQALSSLSDRATGIPPPHQHPPAAGVAAVPLSLPPRARCHARRRYLVERAEGWSLQDLHRLKTTSSLPPSTGATATPSPPQLLVELQSMFAIMQTHVRGCSACASQCRGLVVRTPPGPTVCRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIH3</accession>
    <name>A0A088RIH3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein phosphatase inhibitor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_070810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009376">
        <property type="protein sequence ID" value="AIN95767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704089.1">
        <property type="nucleotide sequence ID" value="XM_010705787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIH3"/>
    <dbReference type="GeneID" id="22572416"/>
    <dbReference type="KEGG" id="lpan:LPMP_070810"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_070013500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_070810"/>
    <dbReference type="eggNOG" id="ENOG502SANC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265291at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011107">
        <property type="entry name" value="PPI_Ypi1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07491">
        <property type="entry name" value="PPI_Ypi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0650">Protein phosphatase inhibitor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="145" mass="15966" checksum="5E2E431DCBC38F4A" modified="2014-11-26" version="1">MDAVSVRQQQSRVDRADSLVPTRTAVLHLRPAPTAEEVEVAQRQHNMRVTWDPEVHEPENQHVSKCCCVFHKKKLFGESSSESSTDDSSDDSKDVDATGAGGNGTGGVHHQGGCEGGCQDAHQHPPRKHRLRCTKAHCYCGTRFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIJ4</accession>
    <name>A0A088RIJ4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pitrilysin-like metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_070120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009376">
        <property type="protein sequence ID" value="AIN95698.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704020.1">
        <property type="nucleotide sequence ID" value="XM_010705718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIJ4"/>
    <dbReference type="MEROPS" id="M16.013"/>
    <dbReference type="GeneID" id="22572347"/>
    <dbReference type="KEGG" id="lpan:LPMP_070120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_070006000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_070120"/>
    <dbReference type="eggNOG" id="KOG2019">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250783at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000057">
        <property type="entry name" value="Pitrilysin-like metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000080">
        <property type="entry name" value="Pitrilysin-like metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000106">
        <property type="entry name" value="Pitrilysin-like metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013578">
        <property type="entry name" value="Peptidase_M16C_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055130">
        <property type="entry name" value="PreP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016">
        <property type="entry name" value="PRESEQUENCE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016:SF13">
        <property type="entry name" value="PRESEQUENCE PROTEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08367">
        <property type="entry name" value="M16C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22516">
        <property type="entry name" value="PreP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01264">
        <property type="entry name" value="M16C_associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95698.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1032" mass="115684" checksum="70A20D4A826D12E3" modified="2026-01-28" version="2">MLRSSVQCLSRCMSRREDLVFSSMHGFTLLKTRRIDGLHLVAYEMKHVRTGALYYHVDVEDSNNTFCIGFRTPAENSKGTSHVLEHTTLCGSRKYPVRDPFFMMLKRSLSSFMNAMTGPDYTLYPFSTTNRKDFQNLLDVYLDAVLHPLLREEDFKQEGHRVELEEKLADSEGATSQTQKRTRRLINNGVVFNEMRGVVSDPSNHFVHSVMRTILPRTHYTYTSGGYPPDILELRYDELLSFHRRHYHPSNSITFTYGSLHPESHMAALNSYFSSFERAVPVLVPTLADQHRFTEPQLVQLEGPLDAMGNPQRQKRVAVSYAVPKENNKLEDVVALSVLDSLLSSGPSSPMFKNLIESQIGSKYAPMQGYAFYLSSPIITYGVAGVDEGRAHVEAEVLQAVESALRTAQKEGFDERRVRSVIFQEELQHRHRSADYGLNTCTGLCAMGLCRAQNNPLDFIDWLPHLRRLRDDNAASLLPRIESHLLSNPHRAVVSVSAKKEYLSKLQDQLKEADEVVNASATEIDKDRVEKETREWLQRLRSAQPQDVLPTLRIDDIPTESFAEPVPCRSSLSNTNGQVYTITHPTNGLVYVHGLIPFHTSLTSAMEHGELAQVPQNVMLLESLIGRTGAGKLSYKEHSIAAKLACSGFGFAPLLNESYLHKSTTITGTSYSFYTTTEQLKEALDLLSVTLLEPRVNADDADVYSCALSRLKMACSSAIQSLQAEGNRYAVIRAVAELTRRGELREHWLGLSQSTHASEMLEKLQGCPEVSREAVRTLLADYAIFAREMATDMSRSLIWATCEDAHREEVERMLKEFLDMFPRTAYAARTHLLLPPSSAAKGIQQIIKKLPIDTSFVGLAMPNELKWESHDQARVRVGCTLLCNEYLHRRVREEGGAYGSNCSATLHGEVGGVSMSSYRDPTPELTAKVFLEAGDWLADRKNVTAERVSEAKLRLFSSIDSPYAADSYGEAYFYNDLRQSRKQAMRDALLSVTPEDVVNAAHYFKPQSPTIISILQPTGESSGVAAVQPEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIQ1</accession>
    <name>A0A088RIQ1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Vacuolar membrane-associated protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_070980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009376">
        <property type="protein sequence ID" value="AIN95783.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704105.1">
        <property type="nucleotide sequence ID" value="XM_010705803.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22572433"/>
    <dbReference type="KEGG" id="lpan:LPMP_070980"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_070015100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_070980"/>
    <dbReference type="eggNOG" id="KOG3572">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="438939at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027244">
        <property type="entry name" value="IML1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048255">
        <property type="entry name" value="IML1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179">
        <property type="entry name" value="DEP DOMAIN CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179:SF8">
        <property type="entry name" value="GATOR COMPLEX PROTEIN DEPDC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12257">
        <property type="entry name" value="IML1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN95783.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2474" mass="261121" checksum="0E2212A96D8641C5" modified="2026-01-28" version="2">MHDGRRFATTTSSSAAAESVQTLVEAIVELRPSSSFQPFHNSHSACGGGVSGSHNFAHQTPGSPPTSNVGDGTTSFLGLPARTQSTSSVGASSYVDLMTASSLISPSPGSSFAGAGSGEGGNMTSAPSVSTNRGGESPHSSAALTRGSPSIPATTVGVAHGGAFSAALRQSGTVSMNAGAISSSSFTSTPPMNSATSAAAGAGSGCGAAGGGGAAAAGAGGPCPLMHPSGGWICRAMAFNEKEVSHANGAISVNQSLTSKCPLINEVAKGKIMARILSSYQEVQERYGLSHVELTVDNQYLSRSDMFLISEVLRERILYEGEEMHVCSFRIRVREMLQAVVTSPSRAASSTGLPTGVASSGGTTSTAVPGVGAPENGINIGAGAVGAGGLAGTAVASAAGAVAYIRVGSGIVLPTTRINFQSLSPIHYILLELSHEMWETTMDGRIALTLAIRKFLSELLLKQLSKRKASPHICVVFTGRLKREFQYGRLRDVFHLLDLPRDLRSNVDIVEEIRMHCEALVDRVLREVQGSAYRQLETEVRAYREAATASHSRASGSKSPRCCPANDGDDLNVVTHSLQEREMSGITSTTSTTNLFPATGETLKRARTSAAFSAAAAATEATFDSYVRARQQCIDDITTKRLFVHAKQSNTLEALSILLERCTHNYIDRNLTLCGHAVTVVSAGKGFYQVTNNLVQVVCARLHDIGLEKVHVVCVGRPPLHVTPLLEYTSNDETLRSQYHLHSCALSGAGAGAGVRGMAGRVPTPLHSGEAERYYETPEWMSVFFFHASLHYKSGGETVFELLPKECWQREYSVMAALKTLRPAQPQPQQQARQQQSQSYAASAMLPGGVTGDGDVEDGNASVGAGATSGVQGRDRVAAAAAMMSSCGSHGTTTGEASLPGVHLPLLIPGLGLRTYPVPEVTLPVHPSSASSLLCADRWGVAASGPPYTAAPSRAAAGVAVAAGGLRSAFSQPLAPLHLQSCAADPLSVSWTGSIGAEHAPSPMSPLGTSSGKAAAAAAGSWLGAAAPVSASSKCSSPLLVRATTTNSSLFASLTAPSQGLMPRGVTGTVTLAAHATARQPTQLQQRALPMLTSNALPHTAACGPLLQQARYVPPRHTFSSMPFTAAGAHSGGILGSEAALAATTGAWSSAQQRRSRTGVTTALGADPHTMAVAPSAFGGGRLSYPGNLPSSYATGCKPTLHISRSFDHKTTANPEYHSLGAFEDSVRSVSSSALVPYNSAPRLQTRSLLWREGSTSKSSVNSIVTSVAAVATSAGTDLGVSGNSAGGGLRSVQLRLEDGPMYRDVMGMVVSFASCAWYCLHASKPHQDSGGGSTAVVVAAGTVAANVPVGHTIVARQGDSGGAAAVIVVAGGSSPSTSAAIGRGLLQQRDGQPSTRVESATSTAAESCYSDASMRPLVKRWHKASNSTRSDAVFCGCNVVDSDLRNGYLILEITINAAVLPQSFWSPRLLLDENYWAHLMSCFTGRDDRLTLDEELEFASEDDADDDTFTASGSSTDKQVLLLNTSGGRRWKEGDDAANVRSSATAAMAMSAGRETGGSTRGGPESGRAIDDYHFQSDFRPAEVFCHSHSGITPDGRTLIIPTHSNNVYFKSPEEIFLRFTPQLFVSTVDEVGGVALEPVGPKTLTSPHPNHTAAADDGVAERRPTEVCASYGVLHYEGREVRSSVAAAVSPTGLPGAFERLEEEEEEGSSAPYMIRSGAAAKATATTGPVDGEGQAWAPPHPPEAGAMRVTSKSGRSSSTDSGAGSRAKAAGGTTMAASPQLPKSACALSSLSASAEAMASTTDGPSQQTAVQPGPATVDAALSTESLPPPQDRTVCAAKPESPTSRPRPLRLRPTGTTTSSPVLATGTPPPPSLRVHTLPLAAVSRQESSSLAGLPSPSLTPTTATHSGGRHPTHGPFHQDEVPLMPGTTVTVGFVQLRNSLLFAIKPINPLRYGSEEEHREDATALSQSAESVSTATVLRRRWQWKHPDIASEPQHLASWTRLCTCRLLPLYGSKPAYPRESFYTVSPHQYTVTSPSSNHADPAEENRRLLEFVLQRLQQQYQIVADSPGLVSGSQWPRAEPSPNARLEMSLGHQTHTLKLGETAKTISVTRMLHRGMYSNGQVTHMLSYRYLLWNYLADEFTTREVHMEAQVGERNAFRWESLDGWLQERPKAFIPRGPDIWLRSREVAVVLLPEDAAHPPSYEEFCRFISYRFSVHLSTHGKVLWKSHEGGVSLDISEATPLTFPATPPLMEVALVHDNPLTLDTRNIVDRVTGRTIGFEVPVQKRLMSVDISLPQEYSSHCCYYLKVSWLACAASVITDWFGSFIANAARFRFHAVPLGCYYMSPKAESLTSHYDVEAASPEEELALRCALMRLLMTPTYHYYPDTPVLTRNCRLVHFSGLCCVIVPPSATTVAQWYQNSFVRQGSVEQLVLLGEFKEAVATARQRVADRAAGSASAAVAHPSTEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJ28</accession>
    <name>A0A088RJ28_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_090760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN95992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704314.1">
        <property type="nucleotide sequence ID" value="XM_010706012.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22572646"/>
    <dbReference type="KEGG" id="lpan:LPMP_090760"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090013100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_090760"/>
    <dbReference type="eggNOG" id="ENOG502RZPB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2104158at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33487">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33487:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="276"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="751"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="828"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1233"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1377"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1430"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1640"/>
            <end position="1672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1977"/>
            <end position="2005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2162"/>
            <end position="2215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2237"/>
            <end position="2264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2493"/>
            <end position="2534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2598"/>
            <end position="2619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2637"/>
            <end position="2668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2780"/>
            <end position="2810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3703"/>
            <end position="3757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3932"/>
            <end position="3964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="4233"/>
            <end position="4258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="4576"/>
            <end position="4604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="4693"/>
            <end position="4730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="4964"/>
            <end position="4993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="5071"/>
            <end position="5104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="5183"/>
            <end position="5262"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5295"/>
            <end position="5322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1233"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1246"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1430"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1648"/>
            <end position="1661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1977"/>
            <end position="1988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2237"/>
            <end position="2253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2788"/>
            <end position="2803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="3711"/>
            <end position="3720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="3932"/>
            <end position="3953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="4576"/>
            <end position="4588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="4693"/>
            <end position="4723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="5210"/>
            <end position="5239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="5437" mass="568513" checksum="10A11B2B25E04284" modified="2014-11-26" version="1">[encoded data, 5437 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJ31</accession>
    <name>A0A088RJ31_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Proteasome regulatory non-ATP-ase subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_071210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S5A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009376">
        <property type="protein sequence ID" value="AIN95805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704127.1">
        <property type="nucleotide sequence ID" value="XM_010705825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJ31"/>
    <dbReference type="GeneID" id="22572456"/>
    <dbReference type="KEGG" id="lpan:LPMP_071210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_070017500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_071210"/>
    <dbReference type="eggNOG" id="KOG2884">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1731724at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000005">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="7"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="231"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="267"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN95805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="339" mass="36154" checksum="2FE3EE260F5C5E24" modified="2014-11-26" version="1">MVEACFLCLDSTEYMRNGDQYPTRMMAEQDAACLLANAKLQANAENTLGFLTTGGNACTVYETLTNNVDAIMTSIGSIPVNGKSCNFSSGLQIASLALSHRTNSRAEKRIVAFVGSPIRETEAALDALAKKLRKDDVAVDVVAFGVEANVELLQAFVRKVCKKENSRFLAVAARENLTDKLMSNAILLGEDLPERAEGGDAVMSGFGVDPNMDPELAMALRLSMEDEMQRQAAAAAAASSAAHESAPASGNVDIPAAPAAPAPVPAADEDEQDYEGMSEEEMMRRAIALSLQEATQGSSDTASPQPPSTSEAHKDEEEKEDDFAKSVQDALEEDEEKHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJI5</accession>
    <name>A0A088RJI5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leucine-rich repeat protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_090540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN95970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704292.1">
        <property type="nucleotide sequence ID" value="XM_010705990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJI5"/>
    <dbReference type="GeneID" id="22572624"/>
    <dbReference type="KEGG" id="lpan:LPMP_090540"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090010600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_090540"/>
    <dbReference type="eggNOG" id="ENOG502SQ3T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="549243at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001052">
        <property type="entry name" value="Putative leucine-rich repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF190">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="829"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="877"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="936"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="64"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="878"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="945"/>
            <end position="958"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="989" mass="105714" checksum="2153FE903CE52E9E" modified="2014-11-26" version="1">MATANGGFYRGSSPLLSLADASLAKASAPSAQGFARTLAVAPRMLPPVDAAAAVAAALPSGIPLDRYQAKLEECAELHRQVEKLTHTNEAVEQRLASCQAEAVQLRQAVHRLESVLQLQNEELLLLRDDRRQRGSGGGSREGAPAQMRMILPAAGAAAPSLARAYGRVGQGTSHSMVTATAADQAVILEYISASCYLGCPTHPQLIQCFFAATSGEALVATEPPLTYAQVSVLHRLLERQPSGSGAVAASTALKLSAFRAWASVHLRTLSVRFENECAGMSTLSDALLHSLPSLAHLEVWCVGNDAVLTKLTNALMGATQVRALSLPELAVGDEGLQALWCLLRTRDLMHAPYIIAEPTDTSGTDSLALNLCTLDLSACDVKDTLTLTQLYCPSAEVLLLPPTDRLTDSLLVEVLQRCPRLHTLDLSGCVRLTDACVDFLNSTAPQVRVLALEHCPHVHRLRLDHVEVLFSSLAHVHVLTSRSLRVLPLPVQQRAILLSLVAPRLSQVSLHGMLLNKEALRRFNGRTEEVGGCEERLRLASVTFSECTFASDDVFTRFLVSQTAVQKLCLYHCKGLSSACWTVSARSGLPTFMSLHTLELVNLRTLTDAALCKLIQACPALQQLNLHGAGWSHLTDISIRQLDQLAELRVLNLLALNPDLVTAPVVTAVARRLPQLQRLYHETAITSVRHSELMESGDTDASHRVGGVDITDASVPASVMVERSDAEVRWRAALRDYPLRLLRLQHHSALAMWTDLARVISPCTSRVSVAEAASEAVLTTTAASIEPDGSAIEVAEAAAAEPSKLFPEMVTRTMAAAIAASAASKTTLPPLTASAPPQQVPHWSSRTVDSLHHEAAPPPSVRSFEEVVPAHVDAGEFSQASPTQQQQQLDSPSSCSSSGSSVCTQNSMQEDSHEEAGRSVKRSLLQCANAAASACVQSHQRRSVRTSPSTSGTSRPSVTAAVAAAAAAVAPHADSLEDVAEVSMGPWEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJQ7</accession>
    <name>A0A088RJQ7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_091250</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN96040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704362.1">
        <property type="nucleotide sequence ID" value="XM_010706060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJQ7"/>
    <dbReference type="GeneID" id="22572695"/>
    <dbReference type="KEGG" id="lpan:LPMP_091250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090018000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_091250"/>
    <dbReference type="eggNOG" id="KOG1716">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848:SF4">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN96040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="185" mass="19961" checksum="BA4BA297D638E1E7" modified="2014-11-26" version="1">MEPHSGGCAPQWTAAGNGADVSVLSDAGETGPDVRAHYYYACRHCRVHLFDAAEVLPHDPREGARKTFKFRRGGPSQGDGELSGEPSGAFSTAGLCTSLFLDPDQTPWVTEDMREASKRGAVVKPDTIYCRNPLCRAKLGTQSWTGSQCSCGAWITPAFRIHARVVDRMLYSAPTSVARTTSSPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJQ9</accession>
    <name>A0A088RJQ9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Adenylate kinase, putative</fullName>
            <ecNumber evidence="5">2.7.4.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_040910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the adenylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="5"/>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="AIN95414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703736.1">
        <property type="nucleotide sequence ID" value="XM_010705434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJQ9"/>
    <dbReference type="GeneID" id="22572050"/>
    <dbReference type="KEGG" id="lpan:LPMP_040910"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040016300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_040910"/>
    <dbReference type="eggNOG" id="KOG3079">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="442176at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN95414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="208" mass="22767" checksum="A8EA6B8A131472C1" modified="2014-11-26" version="1">MSGAAPQQSGTAPLKVFFILGGPGSGKGTNCARLVENFGYTHFSAGELLREAARSGTSDVAKKIGEIIHSGNIVPSEITVELLRQAIADHPSSVGYVIDGFPRKEDQARMFEESIVKATGIVYYDCSEATMEDRLLLRSANAGEKRDDDDVETIRHRFRVNVQECMPVVEAYKANGRCHVIDANRDRNTVYADTEKVFLAMGEKPLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKI6</accession>
    <name>A0A088RKI6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nucleobase transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NT3</name>
        <name evidence="9" type="ORF">LPMP_131090</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697190.1">
        <property type="nucleotide sequence ID" value="XM_010698888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKI6"/>
    <dbReference type="GeneID" id="22573219"/>
    <dbReference type="KEGG" id="lpan:LPMP_131090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130015500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_131090"/>
    <dbReference type="eggNOG" id="KOG1479">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10014563at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332:SF10">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01733">
        <property type="entry name" value="Nucleoside_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="479"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN96537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="500" mass="54663" checksum="F691909DAAE58310" modified="2014-11-26" version="1">MICNFSSMAELYVYATCVFLGISMLMPLNALASAPAYMLDYYKYATRNPNAKPNIPIFWNNILTFYNVASVVTQALVGPTVLTPWARKLSLTFRFVMALTLMMVEVFVILVIPAGGVSQVGAIVAFFVVTVLAGIGKSYLEATCYALVGTMPPKFMTAVMFGCGFSGVIASVLQCIIKASMKDTYESVLHQAYLYFSLALGFMALALGMALSLRFNSYAQEKVGEFRAIKKAKDAAADLNLEEGSEAIQPVLDDTPSSSSRHQPFKGDMAANAEVYGHIIEEGSERARRKAEGADDSDEPSECDDVQAVAHQVGDTPSESNADDRNLTTSEQLLRTRAWPVAKCIWPLMVACFFNFFVSLLILPSLIIPVDRTDKWFATIAILLYNCGDATGRWFSSVKFLWPTRKVLLICIACRFVFIPLTFLCIFRYIPGHAAPYVFFALLGLTNGFFGAMSMVLGPIDTRLHTEGQRVMAGQLMGVSLLAGASVSAMLALAIVPFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLV5</accession>
    <name>A0A088RLV5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_100690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696792.1">
        <property type="nucleotide sequence ID" value="XM_010698490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLV5"/>
    <dbReference type="GeneID" id="22572806"/>
    <dbReference type="KEGG" id="lpan:LPMP_100690"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100013300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_100690"/>
    <dbReference type="eggNOG" id="ENOG502SA1M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266597at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="651" mass="68153" checksum="8AE62E7C211177F3" modified="2014-11-26" version="1">MANAPPLCRRLQLLQPTLPLFATSHNRSPKIASDHPSVAPLHMSYSFAVVPPPAPSATPAFEAHVSTLLRHVPHPTFLTCTSYSPYFTSAESEGAATATGSADHAANAAETSSTQQALSYLHQCLAADVGLALTVTATRATFPAASVQHKSSSPASMLPTTTLTGASRVGMIAVLGDFSRRTSTPPATELGMANSREATRHRSLGLMVLRGDDGGYTRQRLTAAAQKAGASTSPSSPSFNPYFDFADGIDLLGFINSALRSHGVGAMPEASGSESASGAICMCVGGYPQGHVLDRKWGTAQESADAVTAAPAPSEQSLLPYQTPASLRFLDEVDAVLTSTEARLRRAQGTYSSPHPPSVESCVEIAGALLARLDAVRRLWTMPSSYPPDVRAACTRRTIADKVLLRPPGTRQCVAAGTWDASGNVGACVVVTQMITSAAELLDYVEDIRSALCSSVATARSVLCDHDGNSTAATEEKTTSLTCVESTAPAAMLPSSSPSLVVVPGLMAPLRGDQFLRSTLQLKVIPSPPFQAALHEYEGALHSAVETLRKAAASTKDTAHGHSSAPTGVPERKPNCSVSRGAIDMYQQAKETAETCFQERMVDITVAIVRDLRAHGYTHVNFSTFQYGCGDAVGRVVAALAAEGGEAVAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RM70</accession>
    <name>A0A088RM70_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_161480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN97023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697676.1">
        <property type="nucleotide sequence ID" value="XM_010699374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RM70"/>
    <dbReference type="GeneID" id="22573727"/>
    <dbReference type="KEGG" id="lpan:LPMP_161480"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160020300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_161480"/>
    <dbReference type="eggNOG" id="ENOG502S1GU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10249316at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="113" mass="13125" checksum="01447F9A16C8BEFA" modified="2014-11-26" version="1">MLQKAQEALTQEELNLRVRQGLQKRKKCALCTQTFYVNELPGAITHKSILELRQKWGMDVRRGDHMPSPSQLYKREEICIFCMQFFDTTGSMQTQQKLLASTRDGISQALTFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMW1</accession>
    <name>A0A088RMW1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_180620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697896.1">
        <property type="nucleotide sequence ID" value="XM_010699594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMW1"/>
    <dbReference type="GeneID" id="22573952"/>
    <dbReference type="KEGG" id="lpan:LPMP_180620"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180009100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_180620"/>
    <dbReference type="eggNOG" id="ENOG502S84C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266618at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="106"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="214"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="314"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="366" mass="41002" checksum="AE24B81F81FEA1D5" modified="2014-11-26" version="1">MVVHLDALPDLAGAQPNPSREVVAREEATSAADAALSSSLPSRSHSMHLDPYWTALVAQQELNTHEREVAALHARLENADQQVRIMGQQVMAAAEARAAELVEGYKADERKRRAQFQATLDALREENRELTAKLEAAARAPVMGILRATTSPQWAPSGDAAVEARERVAGATSDLLVASATAVSPAEVTRQLQSIEAYWRDRLRTAERHWEDEMSRQTRQRREALDQVEELVRTVEQLQEEVRYTRRQAACLREENTRLCCAAKAVSADGVSTLVLPVPPVTTPSPEEVLRLRQALKEHQHKEAALLVQVESYSEEATRVRLRYEAALERAEQELAAERRRSTEMVKLYGSQLESLHHQLRHRAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNR3</accession>
    <name>A0A088RNR3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15 21">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="15">IMP dehydrogenase</shortName>
            <shortName evidence="15">IMPD</shortName>
            <shortName evidence="15">IMPDH</shortName>
            <ecNumber evidence="15 21">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">LPMP_191440</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 15">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 15 21">
            <text>IMP + NAD(+) + H2O = XMP + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="15">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15 21">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15 20">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="15 21"/>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698138.1">
        <property type="nucleotide sequence ID" value="XM_010699836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNR3"/>
    <dbReference type="GeneID" id="22574198"/>
    <dbReference type="KEGG" id="lpan:LPMP_191440"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190021700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_191440"/>
    <dbReference type="eggNOG" id="KOG2550">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416622at2759"/>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04601">
        <property type="entry name" value="CBS_pair_IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000086">
        <property type="entry name" value="IMP dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911:SF111">
        <property type="entry name" value="INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01240">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 19" id="KW-0129">CBS domain</keyword>
    <keyword evidence="15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0327">Glycosome</keyword>
    <keyword evidence="5 15 21" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="3 15 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15 17" id="KW-0520">NAD</keyword>
    <keyword evidence="8 15 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7 15 18" id="KW-0630">Potassium</keyword>
    <keyword evidence="6 15 21" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="22">
        <location>
            <begin position="112"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="22">
        <location>
            <begin position="175"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="15 16">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15 16">
        <location>
            <position position="425"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15 17">
        <location>
            <begin position="270"/>
            <end position="272"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15 17">
        <location>
            <begin position="320"/>
            <end position="322"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15 18">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15 18">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15 18">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="360"/>
            <end position="362"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="383"/>
            <end position="384"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="407"/>
            <end position="411"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00084116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="AIN97485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="514" mass="55443" checksum="3780B7E5DA652482" modified="2014-11-26" version="1">MAANNANYRIKAIKDGCTAEELFQGDGLTYNDFIILPGFIDFGAADVNISGQFTKQIRLHIPIVSSPMDTITENEMAKTMALMGGVGVLHNNCTVERQVEMVKSVKAYRNGFISKPKSVTPNTPISEIIRIKEGKGISGILVTENGDPHGKLLGIVCTKDIDYVKKKETPVSAVMTRRDKMTVERAPIQLEEAMDVLNRSRHGYLPIVNESDEIIYLCSRRDAVRARDYPHSTLDKSGRLICAAATSTRPEDKRRVAALAEVGVDVLVLDSSQGNTIYQIAFIKWIKSTYPHLEVVAGNVVTQDQAKNLIDAGADGIRIGMGSGSICITQEVLACGRPQGTAVFKVAQYCASRGVPCTADGGLRQVGDICKALAIGANCAMLGGMLSGTTETPGEYFFKGGVRLKVYRGMGSLEAMSQGKESGKRYLSENEVVQVAQGVSGNVVDKGSAAKLIAYIAKGLQQSAQDIGEISFDAIREKLYAGQVLFSRRSVTAQGEGGVHSLHSYEKKLFAAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPA4</accession>
    <name>A0A088RPA4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_202770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698480.1">
        <property type="nucleotide sequence ID" value="XM_010700178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPA4"/>
    <dbReference type="GeneID" id="22574487"/>
    <dbReference type="KEGG" id="lpan:LPMP_202770"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200033500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_202770"/>
    <dbReference type="eggNOG" id="ENOG502QUVU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264567at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="439"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="475"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="508"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="603"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="639" mass="72084" checksum="528AE1508F909D95" modified="2014-11-26" version="1">MLPATDSARLGMIQAAVETATAGRNTNRSFYAQSEVAGRRVSRVTSLDDRGAGAVPCPDASASTSTQRTNDVAIAASSAPDEQQSQAQLQSPQEGWEPPIEEMVNNAVIHLDKPIEHIPVISPPELKLIGRCVTFIGDTTINGESSSFFYKGLVGTINKETVMLIHVYRYTEEDFQLHKLEHRQTLEIHENLKSSAPESAVTSMNNDLCDFSNGNLGGTAREETEANHHNNNLDCVRNTIDADNIQNSNGNDLEFGNEGLSVTEHQEMLNLLNELGETHAEVATRVRNRMREQMGTMGPIPYVTFSRSHIHHVEFGVDPKSSFYSIFQDPMKEHFDMQCLRMFVRRYIIHTSQGNNPRQVPLRAFITSRCNCPDLNDNLLVSVTREELAHLIKIDRDVRRIKKKKEQIRRNALRAYRAPNGLFRLTGILFLTHMPQQTFTIAAMELLMTLVMLLYTIITVVTAESNIIAPYFAKVYSYVLATIIISVLAAGCTSLHALRMTLPIRERIYLSVLRVFFALAVIACSTTTMIIAGERAGYERFLRFADSEDVAHRLCNFYSAHRCSGLDIPCTSIRADLRFCDCPTMTYDSYPCETFIITYIQRGLIPIVCIAFILFATFFFDNYLHVRLFHIAHLLQRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPR0</accession>
    <name>A0A088RPR0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aminoacylase, putative</fullName>
            <ecNumber evidence="5">3.5.1.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_205860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">The Mn(2+) ion enhances activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20 family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.14" evidence="5"/>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN98077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698784.1">
        <property type="nucleotide sequence ID" value="XM_010700482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPR0"/>
    <dbReference type="GeneID" id="22574798"/>
    <dbReference type="KEGG" id="lpan:LPMP_205860"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200065900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_205860"/>
    <dbReference type="eggNOG" id="ENOG502QQEM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6119954at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004046">
        <property type="term" value="F:aminoacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000001">
        <property type="entry name" value="N-acetyldiaminopimelate deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014:SF63">
        <property type="entry name" value="METALLOPEPTIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G09600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PEPTIDASE M20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="4">
        <location>
            <begin position="189"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR005962-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN98077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="394" mass="42661" checksum="1B5B4ECD35902C0F" modified="2014-11-26" version="1">MQPIISLIAAVQPEVVQWRRHIHEHPYVAYEEQPTADYVADLLSCMPAPLDIRRLTPNSVVADLRGGAGEGPMYALRADMDALPLQEESGEPFSSKRPGVMHACGHDAHTAMLLGAVKVLCQMRDRIRGTVRFIFQHAEEVSPSGAKQLVGLGVLDGVSMIFGLHVAAEYPVGIISTRQGTLYGACNDFDIVIRGAGGHASQPELCVDPIHIASEVVANLQSVVSRRVSALKAPVLSVTHIAGGTGAYNVIPDSVHMRGTLRCLDRDTQACVPGLMEEMIAGITKAHGAQYELSWLEPNIVTYNDPKAYEVVKSVAEEMVSKDAFVVKAEPMFGVEDFSEYVAVIPGCFSLVGIRDEVFGSVYTEHSAKFKIAEPALKNGVMMHVGTIMKLMVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQ36</accession>
    <name>A0A088RQ36_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4833 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_210920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698879.1">
        <property type="nucleotide sequence ID" value="XM_010700577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQ36"/>
    <dbReference type="GeneID" id="22574914"/>
    <dbReference type="KEGG" id="lpan:LPMP_210920"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210013200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_210920"/>
    <dbReference type="eggNOG" id="ENOG502S364">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="77762at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032269">
        <property type="entry name" value="DUF4833"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16117">
        <property type="entry name" value="DUF4833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4833" evidence="2">
        <location>
            <begin position="323"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="383" mass="41777" checksum="0F5707E204706E5C" modified="2014-11-26" version="1">MAISLVASGNTVKEDSELFFAVTRDFSVPGASSQYQTPRAFNQLLRSRLRQRNRFNHDHHDTCMYIARSKNANVVAYTANLVDAATKERVVSGIGRQCVLCRDDPLHAYFVNLEPSYVENRRRKGIEYDCDDLNILERTMAYGCLATPVNTEGALGYWSKHTPEAFAALQEEWKAGGTVDAPEEEQKTAGGVSQRAKEASADDASVAPQPASALTVESLDAALKAWWTPLHPYISHFVALPTWPGLVMCLPPVAKSSTSRRSSVAAGELAKSAAATERPPTPPDRACTVDTTEAKPPIADTTNVTYGNHTEPAEATATSGVLSDEDTVVAIITRISGELSLLEKVYVKSTEPKRFYNLPKVEYIEVFGVSLATGLQTYEKKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQ45</accession>
    <name>A0A088RQ45_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_204930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698692.1">
        <property type="nucleotide sequence ID" value="XM_010700390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQ45"/>
    <dbReference type="GeneID" id="22574705"/>
    <dbReference type="KEGG" id="lpan:LPMP_204930"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200056100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_204930"/>
    <dbReference type="eggNOG" id="ENOG502RYVZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="245726at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35614">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35614:SF5">
        <property type="entry name" value="SPRY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="622"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="674"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="867"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="625"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="674"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="697"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="867"/>
            <end position="893"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1038" mass="112800" checksum="A9D673FF656B9387" modified="2014-11-26" version="1">MGATPSREAKPTIRSLRYGNHEIGLIPITRTYFNNQNPQLRQQFIRVRNDPNVRYSHTRLRGYSMAELPPASYTEEDLEAYLDTVERGLFDTNEEMLDAGALQTPMISMMQLQYLLQCGGEVDLYDPTLEKEPESDKGSQPPTSVEPFLLGAIGTSLLPSCNGVSFSDVTTPKNPCPPRENGWLQSTSLSLRASSSGETVKNSPVHPASVVSATVSLSATPSHMLLPPTMPVAPPQDEKAEKMPSAEDCATDWFLKLKGFLQSHHRRTDEFCRPSCNATCKDNGQSSFLPQFYKSEEYLRFKRAVRPVPCAVLFIYVNNREEHDCFTFQGHRVNVIGSFDMRSHDDDHDDFAPTLQIRKAILKAAGDRTLERVLALSTKYYLDSFTEIVLQQLQRRPVAELLVGLGEEARSLLCKVPTGSPAGGSDGCPSMYDPLSIARALFYERITKLPLVVSSPFNNYPALKFIYDFTSLTHSIEDSQFVRPGDLRLCTYDCEKGERGIIFLFHGRALALSWLWATTQTQTSTVRESWAQYTLCEHTQSRERRVQHWLTTDPRAKTLLGDSAITACFEQHLEHLHSEIVRARNTPTEDARSWSDVQEYSHDMKLYRIFLSPLCGPLLTTVKTAKPEKPKDRSNAKRSPAANSAQSAADGGNASTCSHSRAASDLRLVMSPSASALPTNSRSSTQARGKKSPNTPLTGLSTSGRTLSTSNFSTSATTLGGGSSSSAPLYMSGTAPGAFLHPPPSLSGDGATRVTMPRSFMAPAAFASQSAPIAGMPVPMPIYFTDSLEQPQLQPQPVSPMLVTSPPTGISFPMATAPWPLHSFIQSPQPPQSMMTSPNQPPAAVSTPYVVQVSSNGVQTLMPITFASTPSSNTPSMSFQTDASNSRNTNFQHAPQQPPPPSFSAPMMVPNGKGDASSLSSSQQSFGSKGTPYAGASILNSMTPPNPHPAHSLDSAATAAALYPNMMTAFATGNGGATMHSVPHHLAPQQTTAPMFATMHPALAQLTENHTACLATPKAYVPVGYFSTSVPGSPHMPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQH8</accession>
    <name>A0A088RQH8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Kinesin, putative</fullName>
            <ecNumber evidence="12">5.6.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_211240</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.3" evidence="12"/>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698910.1">
        <property type="nucleotide sequence ID" value="XM_010700608.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22574946"/>
    <dbReference type="KEGG" id="lpan:LPMP_211240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210016600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_211240"/>
    <dbReference type="eggNOG" id="KOG0245">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272627at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000184">
        <property type="entry name" value="Kinesin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047149">
        <property type="entry name" value="KIF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970:SF25">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="11">
        <location>
            <begin position="132"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="98"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="868"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="979"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1785"/>
            <end position="1820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1893"/>
            <end position="1937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1969"/>
            <end position="2004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2058"/>
            <end position="2090"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="485"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1104"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1291"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="876"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="984"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1035"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1787"/>
            <end position="1820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1901"/>
            <end position="1911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1970"/>
            <end position="1985"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="215"/>
            <end position="222"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN98203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2139" mass="232438" checksum="1FE54D2EF6860CC8" modified="2014-11-26" version="1">MGRGAAHEEYPDDGHIFVCVRVRNAPQNAACLTHNSAAATNTRASAVLRKSVLREAQRICVSVVENVVVMHDPTSIDDDATVAKDGNNVVQMLTDRAHRTGATRHSRKAAGGGSAAAALSRTSSRRTAGGSRVTTAGAAAGATHIVSTSTANYYECDHCIASMEESHLLQMPLIRTSDFLQPPPYGSQEEVYRRTAMHAVKAAIDGINSCVFAYGQTGSGKTYTLFGDTTNIRRDPGVVPRTLDDLFSRLEAVKQSYQSDRVIDYSYRVQLSFYEIYQNEVYCLFSRRGPLHVQFVRDPTGRKETMIIHDLQQQTVTSAEKAYPMIEVGLRRRQTAETGMNSRSSRSHAVLQVRVAQYRTNCDTRETVEHQATINLVDLAGSERQKTANTSGTSRAEGIQINQSLATLARVINDIASGAKFVNYRDSLLTMVLKDNLGGNSKTFMIANISPIAFSYQESCATLTYARDVRKIRNRPMVNKTFQTRANLLEQNMTLKQENEKLKEQMEAWVRGLQSSNLHPSETDAIGLSVRGGSMAEASDHPLLSPPLSMSQTIAAQQRRASNVPLDVAGCNEAFLSASSAGLTAPLLISSHRKYTSIAGIGGSCVEGGVVRVTALVKGTMEFPLSRVLYSLPSTTTTGESLYTAGEDGHNTQKWHTAILMGADANSSECASGGNTCRPDTVVETTAAVAEKMLDLGSLVLERVAQRSCEQRYYVHFNPPASVEGLSRLIDVQINGKSVGEKGRRELHHGDVVCAYLEDGAKAEAATETAASACLHAQSLVSFHYVDLNALSRGTNTSSNGMSSATLGQIAVSVDLPADMESLTLEDIKQLQRDNAKLLDMVRQQAETINYQCAHTSTSMGQAENLEGISPIETPGSVSPNPRSLEPSVSTSLPPETSKIVVTLEAFRRLSVSPSIRRGSVMPADLETDELLQRAAAQSESKQRLDSAVHENEKLHRTVVSRNATLEALARRLAELEAGGPLDTPTTPSASSSPSSVSVSPSAKRDDTDEVQTGRCADVDEVGNNVSMGTERDCSSVTRVSSPSQMRAAFEQRQDEGVVEADEEDGLQLEPIGDGRKRIVYESTEGTRERYQAVVREREQFDRIIELETLMRELRERISELESRLRFSKDETLEQQMFREQAEDERDALLEELANTRSENAMLRRENASLEGFLARDEQALADAARLADEELERQTAVLTDRIKALKALARMWKQRTMKYIAMGYGAGSDDKGTGSARAAHLEAIPWDDLRAAETAAIAKRRLGGGDADACPADVAHTIDDFEKSTTEDNVRALEYALLDFEQENQRLLDRIRHIQAELNGYKSLIGRLRAEKAETEKALADATDSTEEERRRMQQLLRSTNAQLEEAEENLKRTQGRLDDAVGLCENNKRKAVRNNGLLLAQQKRTIEELEAEIHHMRRDYAAKDEELTNLTRYMQDRDALGGDGVAQNCKLHSRIEELVKDSMEDYEAPNGYSVFPAGFEFSDEMVSLIRICLRILLDRLKMELYVLNAQSVHKFQLLIHAVKARTEAHFHTFVHQLRDAVSQMAGRTLRPGGKWGLSESDVLSTLVDHRRRQVGDALSGLLIWYDHWDSAPKMEHVAYMELIRNADRIMQMARIVRRESLLNTNATSTSLMPIPGKNGASDTSFISESARRNDKTVKGSCKILSRLASFTRQGNLARAVNQFSATPSRATIAGREGVVGTTPCPVEEGTTPFSRSATVTALALSQSMIPFSRTGTGTRIKGHQAPPAANPESCSLFSRCPSGLPRPLAATVAVANLSPQSCLSTATPARPTKPAASGVSGTPAATLTTGTTPAAPTAAARTNYSRMASAGVLPVSEADVDYVANTDVAEAVSISTYNFSRRMSLAATVGAGEGTTADKGEPVRRPSRLFSQSQKAIFQQRDSSQHQQQPLRRLVSATPALSKSRVNAGATGTRVQASRVKATEAFARSKTHYSVLKPTEMVGRLSRRNSGACVSSKTSTHTAGSLGGGSPHARPSSSQHNASRLSAFYSTPAAVQTRGSGNGPVSMLSNNAAAKLSSGEASFYNPDVMKSLRERSTNDVNSAARASSEPRAVSKKASLTGGSSVHLKKSKAHAATSLSAFQKALTGARVSAGHDTTVVSSAPVIPKLNFEALEEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQK5</accession>
    <name>A0A088RQK5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_221140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98407.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699114.1">
        <property type="nucleotide sequence ID" value="XM_010700812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQK5"/>
    <dbReference type="GeneID" id="22575160"/>
    <dbReference type="KEGG" id="lpan:LPMP_221140"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220014800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_221140"/>
    <dbReference type="eggNOG" id="ENOG502S2WR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267858at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98407.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1065" mass="111399" checksum="3354BBE530E8F013" modified="2026-01-28" version="2">MSQLLSTYSLLQCVVSAAQFASGEISFYDTYAELTAADADGSRTSPLRVEYDVLEHFRIVRAQGVMRLTLPRGVVRQWAAQNSFETQLDEYEGVQTNVHDGNRSKADVFSIQMTDTKSVLLVQLSLEDMAAFLNSIAPLIAASRRTRSMSRISVTEPLPVYGVPLVDPAASMPTDAATSSRAMSTASANSQEEAAESNWASGKNNAAPVCDRRHYRHQRQRRGERDTAHCTPSRTDDNAGQKEGCRFAKHSDERRTTVAANNAAPRATDTAPELLGGDSGGSSIGATESETHGDAAQPLSGSPAASTGCEEDEGGSTRRTVRVADALAVTATAGATAQVDRRPSSPKHRQLQQATPSRFVNTLESVAEELAELMEEADQPEHYRGCRGEPLHRRQPTAAAVVTAVQRAGQQQSSRCTQRRPLPIAALTAASSVCPSLKSTISETHVLRHPHRQQSPSASEAQAQCGVNGVHSAAAADGGTAVTNRRSAQWPMGMTTPVQGRCLARTFVRSGGGAHLCASELSSASTAELPPLATHGGCDGRAAPQEGRAMPSPASEERPVCIDKASTVDGAALCNVNGVRRAADGWTGSETQWAALRTGTVAHAFADTKDGCRDDACAAPVATPIQSSSRPSSVASSVKLGDMLALPGASRELGGPAKGVIASSQRLAQFRSGGAGAAPVKPSPPCAGSSSGAADVAAYLRELFPVEDTVPKATRKRCKAQTVTTAGAVGRLSVSQRRRRAPARRAVDLTASATGAVTRALVSTDIPSKTADGATTSQLPLKAVPSPPLAKMSSNISAAIATHAIANRRRRSLTVGAVGTAKRVKVDAAASVLPLDSSIDAARDKEKDTEATTGSSTTGHCAAACLTQPPQPKVCSAVSVPQRVAISVRDAGALGLVQAPLPLCGAAWDKKPGVAVAAKEEAAAAAAAALNDDAAKAVEGLIRGPSAEADSRKAPRDGVRHRRTQLLRAKLLVQEAAPPAGCADDPSRYHTEAAAAGHHGKTGDRVSISSSQATCPLLYCRESRKERSRRVLRYMNLISQSIAAVHEAHDALRGLLLLMMEEDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQY2</accession>
    <name>A0A088RQY2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_220900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699090.1">
        <property type="nucleotide sequence ID" value="XM_010700788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQY2"/>
    <dbReference type="GeneID" id="22575136"/>
    <dbReference type="KEGG" id="lpan:LPMP_220900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220012400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_220900"/>
    <dbReference type="eggNOG" id="ENOG502S9TM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="243070at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="491" mass="50692" checksum="AD7BCC5E6E003F11" modified="2014-11-26" version="1">MRNPHAGSLAFSTTGHMQIEAAVRVDIPVRPSTLQEAGTSTDAEGDASGVTTLSAMSPATESINGAIGQRGADGLTEEAANVAATTTAALATHPLVEPASSHLRFTDFTRPLTVAASEATASNATARAPGPWGQLELDMFLPNWSANRQSIGVRAGPAALRVSRTLSASAAPASKSSMNSASLSEDDLHAATVGTGGDTNRWYQYTLDAAVCVPFGGSDVDASRAARRTLDGKSVGVLPAAPWALTCGMQLPLALGDTLIGISLQNDRASSVAMQLPGVEWAVTAPATASPTAFSSPGNPLLSATDDACYVACVPSLLYPSHSTSSSSDPGAAAAAPLYVAIPTTTVRLLLVQTLASHTLVRRDASNLSASQMSTSGSGYGASTRGFHLASSYDWRQLPTLVGVNVGFNRDRLRINAASILHNGEVDLEAAAVLDVTPWMPRMPTLLKLGYNNAGRVAAGITSLFYETVTATLGVHMARGEQAKFGIEVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RR96</accession>
    <name>A0A088RR96_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_202200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698421.1">
        <property type="nucleotide sequence ID" value="XM_010700119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RR96"/>
    <dbReference type="GeneID" id="22574429"/>
    <dbReference type="KEGG" id="lpan:LPMP_202200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200027400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_202200"/>
    <dbReference type="eggNOG" id="ENOG502S0NJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272549at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="38305" checksum="1BDEDD3BE9EC4441" modified="2014-11-26" version="1">MPGSLRVQASKRSARKAVKRSLPKEGNIAHGGTSAGGVDSATSASVVTGSAASTSTLTNAVTLSTSEQERAVEAVKETLPVSASRTELRKDPIYRIMHALPRSDVLEVVRCRFAKSHCERAAAYFDLSYMKNPLRHLRLQLGCDGPTGIHLFFQRIAAHRHTLRVVDFSRNRLSTDDAILLCNTLGLGSAGDAATALGTTRSSSGGVAADLTVSTTARASAPPPSSLELLDLSYNTKLGNDGAIHVVTALRHCPSIRAVILKSVGIDDDGVMAVMDVVRRWPAPTLCAYSATPHALLRPPTASATKFYLNLNENYIGARGTHVLGKGLPDHVSLTLAKQRPRPALDRKRSRDDNGTACR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RS27</accession>
    <name>A0A088RS27_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_250790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699649.1">
        <property type="nucleotide sequence ID" value="XM_010701347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RS27"/>
    <dbReference type="GeneID" id="22575727"/>
    <dbReference type="KEGG" id="lpan:LPMP_250790"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250013900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_250790"/>
    <dbReference type="eggNOG" id="ENOG502SIWS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266058at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="392" mass="40464" checksum="23E315177579B1D5" modified="2014-11-26" version="1">MGQSVSSSQANPSNDEGIVDAAKRHEPRCAGRANPLARKMQGELYTPNFPPLASGAGAAGVDSSTCAVGSHGNASDSAAAIPIFCLDASEQNMCQLFKWLELPPAQRAKVLQEVSKNVCGVLLHAPATTSVGDLRQFLLGQCPLRQRTPDKSALSPHLLAIRDPLLASAGGAAANGTPSGGSAKAFSNSLLTLPDSMVLSTLSMNKQLFFLPGVGASEADCNQLAAGHASVGAADSYPAALGREDAEAEKAAAASPSAYADDVSTAGRALVLLYSYEPSFGIGCNDILLLGCCASLCACIAASICCCINAQKDGSPSNVDTMPNNNNGDNGVPNYYYNPGNGTSYYAPPPPPPPPSPPPPPLNYYNEAPEYGMPPNTYPSANPYPVYQLQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSM5</accession>
    <name>A0A088RSM5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aldehyde dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="7">1.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ALDH2</name>
        <name evidence="7" type="ORF">LPMP_251150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="7"/>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699685.1">
        <property type="nucleotide sequence ID" value="XM_010701383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSM5"/>
    <dbReference type="SMR" id="A0A088RSM5"/>
    <dbReference type="GeneID" id="22575763"/>
    <dbReference type="KEGG" id="lpan:LPMP_251150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000019300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_251150"/>
    <dbReference type="eggNOG" id="KOG2450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07091">
        <property type="entry name" value="ALDH_F1-2_Ald2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000011">
        <property type="entry name" value="ALD5p Mitochondrial aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000001">
        <property type="entry name" value="Mitochondrial aldehyde dehydrogenase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="29"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN98978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="499" mass="53854" checksum="10191C4EA1BCE5E9" modified="2014-11-26" version="1">MLRATLTRLEVAPKVTHIQDKLLINGKFVSAMSGKTFEVVNPANEKVIATVAEAGKADVDLAVKAARHAFESFRTTDCHWRRNLMLRLADILEKNGKEMAALESLDNGKPYEVALNVDVALSVECFRYCAGFADKVDGSVPPRSGNFLGVVKRQPIGVCGQIIPWNFPLLMAAFKLSPALALGNAVVLKPAEQTPLSALRLGEMVMEAGFPDGVLNILPGFGATAGAEIARHMDVDKVAFTGSTAVGREVMRMAAETNLKKVSLELGGKSALIVCEDADVEEAAQVATTGVYFNTGQVCTASSRIYVHESVYDQFVSCLRRNAEACKVGPGNNTANNMGPLVSKKQQERVLGYIDDGVKAGATVVTGGKKIGDTGYFVQPTIFADVKEDMRICKEEIFGPVTCVMKFKDMDEVVKRANDTIYGLAAGICTRSMDTALRYSTYLNAGTVWVNTWNNFCATMPFGGFKQSGIGRELGKDAIELYTEPKAIHFALKGPIVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSX0</accession>
    <name>A0A088RSX0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Opioid growth factor receptor (OGFr) conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_260880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699909.1">
        <property type="nucleotide sequence ID" value="XM_010701607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSX0"/>
    <dbReference type="GeneID" id="22575991"/>
    <dbReference type="KEGG" id="lpan:LPMP_260880"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260013500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_260880"/>
    <dbReference type="eggNOG" id="ENOG502S1YE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9030204at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140625">
        <property type="term" value="F:opioid growth factor receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039574">
        <property type="entry name" value="OGFr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14015:SF2">
        <property type="entry name" value="OPIOID GROWTH FACTOR RECEPTOR (OGFR) CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14015">
        <property type="entry name" value="OPIOID GROWTH FACTOR RECEPTOR OGFR ZETA-TYPE OPIOID RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="388" mass="43368" checksum="153D5808DA0FF313" modified="2014-11-26" version="1">MEVQQQQQNYCETLAADEAADGDEQNGQPRVDVAELHPSVRFYRGMWNLTQLADTVFDDVFSSTDGSDDDKTVSVSALSVVGLHQKLLPPAVVSGLGDVADESYAVQLASSSGLEFLRLRWHVLLPLLFPCCRWGDEVGAISSDVSCSGRESISDGAGNGKCSSHKQQGFSITEEGTSFPAESACSAPELYELLLCRPLVKNDLAIIREPGLMDRVYYSYVVLLRFFGWRVHEEERGLLDRHRAWQERYALLELYRTSTTVTAAAQLAPDTTAAEPYGHVDGDDIKDKSTYHAQRALPPPSPTYRTFNFYESGLPRVLRCLLDIGFLRLAVRLVEFLLEEMVCGRLLFLLPLVEATLLPILVQQPHVDSSHKTRLRKRLYRLTHSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RT18</accession>
    <name>A0A088RT18_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Helicase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_261540</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699974.1">
        <property type="nucleotide sequence ID" value="XM_010701672.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22576057"/>
    <dbReference type="KEGG" id="lpan:LPMP_261540"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260020800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_261540"/>
    <dbReference type="eggNOG" id="KOG1001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="261644at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16449">
        <property type="entry name" value="RING-HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000135">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF17">
        <property type="entry name" value="HELICASE-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="1575"/>
            <end position="1621"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="1678"/>
            <end position="1843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="106"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1031"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1828"/>
            <end position="1849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1830"/>
            <end position="1845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN99267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1878" mass="203941" checksum="511F567E5F0F5553" modified="2014-11-26" version="1">MPPKRAKWKAVEAAAGKSASRKRGRSMTAAANAPTAEEHIVEEAQASSSPPSQSSSNSNSVVSIPPPPALIDVDAAPCEVPVEGKLRQATRQTTLTGAILNTAPVPSRVSTKKSRSRDGVDGRKRGAVGGELKPVPGSARISLKGATPSLPLEGPASAALLEEALLTHLRSALARNYMLMTGRTIELAAQPHTSNMMGVLGALAKTTEVEETAAPADDNADEPDNDASSAKSLALEASGVNDVAMRAVLPCVQYFIISECARVARVVRREGGKGYGDDPATRAAELLGFLLSMLDKHDTFSTLLALACPSCRVAGVSYSAFSCLTQYMVLSQRASAEEIPLMDQKILIERLGLLDGCRSATGCPLDVVECCPFGVAHVHLYLLIRTSPGERVNSRLAKLRWQHKPFELLSFPSLAKAAKAFDTAMDRYMADRTRDLIRHQRIAPNSAGGWAPLTGKQAKSPQFTAAQRALLKPKAGCLTWAEELLRAILPETATQPWHRNSEDLQSRIRRFYAYTCADVNHGGYFSATLEPASALWFSPSSMGSFMSTTSLVQARLLFSQMKVCQHVAEAVQHGGRCSCHSHHNAAAAAVLFVEAHGPYMAARRHCCDESYLLVGNDTVNLSRTTDAAVDVDAVEEKATTPGAAAAGGCQEAASFYAAGSFVRFQATLGVTGSMNAAQIVDCVARVATESAEALPVSQVPRQYIQAELKRHQLESVQLMWNKECGGYREHVSVPLYHIDTGAVLAARHVGVMYYCAATNETIVARSSGNSVAAGREAEADVDAWNVAGVRVRGGLLCDDVGLGKTLSILTLCAYDRAMREASSSDTKEAKALGSEMASVARRFWQVSVKPAAMRHCILGFSPEVLHWAFGNFRSGIVPHPTMPTRLPHTTLVVVPLSIATQWIGEIHKFYPTASYILFYGAKRAQYTADDMQRADFVITTYETLSTHLRQEASGLEFWMTRAADETDDAVCAKAASHGWSNLMPSELLAAVQQYASDVVWPAASGMREAGGTGIRLEMMQSSDCAAVPPLQLGQGETRSSRRVSGHDRAQRGGGAKLQLPSPAAAITTTAVSGTWTLEFDAVHGMPAFRCPAFSLSVSFDDSVVDTALRSVYRHTCLPDTGAVSDAFLDHTWELLKGYSAATAAAPATQVEITQCRLFDGQGTHCATSAFLALLFHAAEMYTLPDPTRRELVRHVLLPPLWRVLVGYWANMKAHYADVAVAEATGRPALRITDLLFRRVVLDESQKCGAASLFHLLSGERCWAVTGTPINNNKTESLGLALRFLGLHSAARLLSRPPLRHVYLTHAYLNTHNVSAYYTAGHFLSHSVNRGLRSLWVRRHSDALPGSVEDEVAFCVCAQCLQRDLYGTSEASLANIPSEYRLWSPPRDLQVGLPCLPSSLFEVLALTMVRHERNQDVRRELQLTPAHYQVHYAALTVDEMHLYDRVALVIMSVAARLHRQGVLSSRMGYAMQWVQELCRLCLHPSRVGNDDLLRGDIEAHVLRGVRLMSDDRVCGINISEVLADSFVAATPQEALEWVTSMAAARKPGLLRNSSIPEETATTLAEIAQVPPLLPQCGICMDNMAAPTLLKCLHMFCKECVLGVIDASRSVMGNVNAKCPYCRDRKSMMEEKRVVMVDTTVPMKVVAETRHNDKSSTTAAAHSGDEDVNVVLARIGDGSRVRAFLEVVEEIWRTQPDDGVLVFSKYPAFLQLAYDAVAARGYAPHMVCGASSLAQRQRAMRAMQSSSGDSALSQRRILFVTSRSANAGLNLTFANHVVFLEPNLNPAIEHQAVGRVHRFGQLKQVIVHHIFAPHTIEEVIYRRSVRLREQAAQGQQSPTSATPGTGTRDSDALQRRTQFGRIAPAEVLLLLEYPVSPQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTH3</accession>
    <name>A0A088RTH3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stress-response A/B barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_270750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700164.1">
        <property type="nucleotide sequence ID" value="XM_010701862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTH3"/>
    <dbReference type="GeneID" id="22576251"/>
    <dbReference type="KEGG" id="lpan:LPMP_270750"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270014400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_270750"/>
    <dbReference type="eggNOG" id="ENOG502SBI3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="42919at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37832">
        <property type="entry name" value="BLL2683 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37832:SF1">
        <property type="entry name" value="STRESS-RESPONSE A_B BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="1">
        <location>
            <begin position="24"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="127" mass="14220" checksum="5A37DA79E3AD1D57" modified="2014-11-26" version="1">MALDAANSKEEAHEKSLNPLVNSVCQCVHLKLKGPLQLEKLCELLKRVRTSVPGLIELHFGESMTLSTNKTDSAEGNTHALFSRHQNGHYLRMYQIHPARMDLMNYLMSTAERPATVVDFVNVTSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTJ8</accession>
    <name>A0A088RTJ8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_231290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699286.1">
        <property type="nucleotide sequence ID" value="XM_010700984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTJ8"/>
    <dbReference type="GeneID" id="22575334"/>
    <dbReference type="KEGG" id="lpan:LPMP_231290"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230020400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_231290"/>
    <dbReference type="eggNOG" id="ENOG502S5NR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="238856at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="123" mass="15021" checksum="F7E8E73087F06C22" modified="2014-11-26" version="1">MGNPYQCEPEVKWYHILWDMRSKEFRQWYLTKKYRDMRIMYKYESHILYQKAGMGFLMAAVFMSVFSSDLAVAVFRWPTEDPNELLKSRVWQKYHNLVNERKEYAEKLLQDSNYVQKKNNSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTZ4</accession>
    <name>A0A088RTZ4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="7">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_270050</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="7">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="7"/>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700092.1">
        <property type="nucleotide sequence ID" value="XM_010701790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTZ4"/>
    <dbReference type="GeneID" id="22576181"/>
    <dbReference type="KEGG" id="lpan:LPMP_270050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270005800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_270050"/>
    <dbReference type="eggNOG" id="KOG0348">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="422663at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="66"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="344"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="626"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="646"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="666"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN99385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="691" mass="77768" checksum="30640DD8A6F7370B" modified="2014-11-26" version="1">MSGTGSSLSVQLTASSTQTSSFRASNPTDVDSLPPLVELVHPKLRRPLTDSMKIKSLTLIQKLCWAAVLDSDSDVLVRSETGSGKTLAYALPTLHRLLMECDQTPISREVGTLIIIMCPTRELVLQVTETVCTLVRCAQFITVGGIHGGENRHKEKARLRKGLPILVTTPGRLLDHLKTTASFNVANAQTVIMDEADRLLDMGFEKALREIMELLEKKCRHASSLKRILVSATITDGVERLSHFALRKNIARIGETQDTFSVPTTLKQHYVVVPVKHRLSVLLTFLRSQLDAGAHKIIVFVLTADSAEFLYLLASRLQSPFHSKSYEGKVVTRSRRAPMSTKKMIETANGHLNNDAATDKVITFEEVSDNETEGDVSLDSTAASRRAFLDANIFTLHGNMSQVDRAAVFHAFKYDTGKSRSGKSVLFCTDVAARGLDMPKIDWIVHYDPPTDPKIYVHRIGRTARIGNSGDSILFLAPDELGYAAYLTHFIHSQMQQGDNKEAMAMSERKYEIFLFYLTKLDPKSNHMWMQSTAALGRAISRLVMQREVDRGGDAKDSLYRVALFAYQSYLRAYAGLPREIKSLFFFVSLHLGHVAQSFGIDKSPSEMQRELKVYIREDRVLARDNRKGTVTNSHDGEGHKKKRQRVELDHEDQYHSMLTQKQRKLTRDWAEKRRKESTKIRPLQFSEFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUE0</accession>
    <name>A0A088RUE0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LSM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_281040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700444.1">
        <property type="nucleotide sequence ID" value="XM_010702142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUE0"/>
    <dbReference type="GeneID" id="22576549"/>
    <dbReference type="KEGG" id="lpan:LPMP_281040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280015900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_281040"/>
    <dbReference type="eggNOG" id="ENOG502S8I7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273307at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="17266" checksum="A15CDD7A6AE79CC3" modified="2014-11-26" version="1">MSANVNFSTGSRKTNAAPSAPAVSASAAPALQNSASSSSKSKSRMILPYEVLFNLVGRRVTVVLTKGSQELEGTLESVDSDKGDMLLSDVVCYTWEPLRSSEEEETTAAATGKGQGTLSAVAEREGYYKCFGGGQRRELSRCSQAMVNSAFVALITPTLFIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUM2</accession>
    <name>A0A088RUM2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA repair protein RAD50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">LPMP_280540</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18 24">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SMC family. RAD50 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700395.1">
        <property type="nucleotide sequence ID" value="XM_010702093.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22576499"/>
    <dbReference type="KEGG" id="lpan:LPMP_280540"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280010800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_280540"/>
    <dbReference type="eggNOG" id="KOG0962">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18797at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000593">
        <property type="entry name" value="DNA repair protein RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003639">
        <property type="entry name" value="RAD50 DNA repair-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004584">
        <property type="entry name" value="Rad50_eukaryotes"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00606">
        <property type="entry name" value="rad50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867">
        <property type="entry name" value="RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13558">
        <property type="entry name" value="SbcC_Walker_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="14 19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Rad50/SbcC-type AAA" evidence="21">
        <location>
            <begin position="6"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="828"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="193"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="761"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="864"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="1010"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="832"/>
            <end position="845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="AIN99688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1361" mass="153942" checksum="A2D73E6D76F1D0D8" modified="2014-11-26" version="1">MTSIEKLQLCGVRSFDPNPANQQFIQFQKPLTVILGKNGAGKTTIIEALLNACTGAMPPGSGAERGSFVYDPKVVGETEVKAQIRLIFTGKGSKVMQVIRSFQATRSAHRVTFTTLDNTVAFQDSATGEVISSTYRSSDVDRVVPEMLGVSPAVLTHVIFCHQEECNWPLGPPKDVKRIFDDIFAATRYVLALDRLRDNSKEFRRQLKEHEASLMALREHREQAKQLEQQIAQKESLVKAIQSRSIGIEPELRGLCQAREELRAVEEQIETLQREVAVTSGRLEERREAIRRMGAPTTSQTLEDLLEIRRCFGAQMQQLEESLVRDTKRHDAAAARRRIQEEEMYKCRSNVQLLEREALVHKGNVVQLRELIQHLSSEYVLSEDSIDELSLQRVLQKAEVAVSAARQRICAATECVQQRIQDAEDGVQGNSRAVDGCNREIEMREHALEGVCRRIKENAAAISALGGDGCRTQLLQVQTEVEELQQRVAAAEVLRKKGGEAKRSQHILMELEGQNSAVAQLREEMMQQKLMERQGHDLVLLRQQVDESNAAVATALQRDVLPILQEIGMQVPQDVGADTFSLQTLTSLRTQTAQVQQLKAEDLRALQTRVLELENMCAIEEQQMSYNTNELDQCRRSVDAGTRQCSGLVSNMEDYEQMLLQAREAAETASQRRHVLETLATCYHDFMVVAREKGMCAVCERSFESEDALERFLTRNAAKQRTSPDQLAAVEAAVTKAQVTYEGFEKLQNVVATVRRNLPRIPDLEAELEALEERVKKNRAEQRKVSAARDASQHVVHQLDIVFQHLCRVCTMGEKTVALRDTLRRKEKDAEAAQAEQQRQPQIRRMQGSGDGAAERVQLPQRSFEELSEAYAASTERLHQLNRQFAEAQRMECGQDENAVHRQLQERKAALFQAEVAVAKLEDLETVARELQEEAVHHRTRLEELKVQATEAQRSVEVHQWRVLQLRTELQKVEAAERGALDTAEQQLRQLQLSLPAVLSYVQNGCNQRLEGLRGHLRETESAYEAATQEEEELASRINEARTTLSDQHRRSADMDRQIDVLQQAVSIAADEARLTETERTLASLKSDRLHDVEQLLGEGAGQASLAALREMITAKITSLEKIRAQQDGNTEAMLLDVSQLKQQLRGDKYQNIEKRYRSTFLKVQTTEISIQDIEKYYSALEKAVQSYHQEKITQINQIIAELWRLTYRGSDIDTVEIRSETEGTTTTAARRSYNYRVVMKRGNNEMDMRGRCSAGQKALASIIIRLALSEAFCCDCGILALDEPTTNLDDDNARSLADALRTLIEVRRAVKHFQLVVITHDEQFVRALGGQSLEKFYYVHKDREGAFSVIDERTFDQLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RV31</accession>
    <name>A0A088RV31_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Long-chain-fatty-acid-CoA ligase, putative</fullName>
            <ecNumber evidence="5">6.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_281220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="5"/>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700462.1">
        <property type="nucleotide sequence ID" value="XM_010702160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RV31"/>
    <dbReference type="GeneID" id="22576567"/>
    <dbReference type="KEGG" id="lpan:LPMP_281220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280018100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_281220"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05941">
        <property type="entry name" value="MCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000045">
        <property type="entry name" value="Acetyl-CoA synthetase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000082">
        <property type="entry name" value="Putative long-chain-fatty-acid-CoA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF8">
        <property type="entry name" value="ACYL-COA SYNTHETASE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="291"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="636"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="259"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN99755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="742" mass="82210" checksum="FD600BE077BDD863" modified="2014-11-26" version="1">MLRAFSLPLLNKVPYATLFKYNHVLQSVFKAQSSKVALTLELPGMPNAQFTYGQLQRDVVAMADVMVRRKEAVAQARGETPLSWLQPCRPGHVRSVFAQGEWTPSCDYMKDTGFYTMSILCGPGYTYVVSLLAGWSLNQLMTPMSVSQQCNTELMYVQEHSGCRSVVGETQLLKEKFPAEYKDLYVCAEEDIGKVPWSVSKKEAATHSATTMASNTFLVDTVYDATLLLREIAAKRDMKGTATLKAKWLPPAESACAPMRSAEDLVRRLDDERAAAKARELDRQAEIVQEEHFHRNRAPAEAWGAADLEDDDVDGDGLFCFDSVHLDKLNHVYQRWYGKPATRPTKYDDCLMIYTSGTTAKPKGVVHTHASVANMVKVLQDAWEWRETDSILHILPWHHIHGLVNILLCAIASNARCVITTFDDAARVAHRLEKGDITLFMAVPTVYTKLIDAVQRRFSPIEKTGFRKACMRSVRLMVCGSAPLPVPTLNQFCELSGHTLLERYGMTEIGMALSQPLYPISDRHPGTVGSPLPTVTTYLHQPETAEAMEQASAKKAEHDEVGGLGIASESLFDRYWNNATATKKEVRTNAEGLRFFDTGDTVGMRLQVGKPAVYTILGRSSVDIIKSRGCKLSALEIEAALLVRKDLFYEMAVVGTADAVQGESVVAVVAMQPEAARARGITFGEGIASHESTAVTEELKKAALELLAPYKCPSRYIIVPEILRNQTGKVNKKNLKKVLNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RV80</accession>
    <name>A0A088RV80_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_283060</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 8">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700645.1">
        <property type="nucleotide sequence ID" value="XM_010702343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RV80"/>
    <dbReference type="GeneID" id="22576751"/>
    <dbReference type="KEGG" id="lpan:LPMP_283060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280037500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_283060"/>
    <dbReference type="eggNOG" id="KOG2250">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6718861at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004354">
        <property type="term" value="F:glutamate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05313">
        <property type="entry name" value="NAD_bind_2_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.285.10:FF:000001">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000002">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000030">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.285.10">
        <property type="entry name" value="Glutamate Dehydrogenase, chain A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050724">
        <property type="entry name" value="Glu_Leu_Phe_Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006929">
        <property type="entry name" value="PRK09414.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43571">
        <property type="entry name" value="NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43571:SF1">
        <property type="entry name" value="NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="209"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="7">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN99938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="452" mass="49444" checksum="08F2D06460A4B2B2" modified="2014-11-26" version="1">MSSFNLQYTSVNDFIEKCVLSRDPHQPEFTQAVREVMTSLWPFLQKNPKYAKDGLLERLVEPERLIQFRVPWVDDKGVTHVNRAFRVQFNSSIGPYKGGMRFHPSVNLSILKFLAFEQTFKNSLTTLPMGGGKGGSDFDPKGKSDLEVMRFCQSLVTELYRHIGADTDVPAGDIGVGSREVGYMNGMYWKLRNTNECTFTGKGLSYQGSEIRPEATGYGLVYFAQAMLERVNDSLNGKTVLVSGSGNVAQYTIMKCIELNARVVTASDSKGYIHDPCGFDKEKLAKLMRVKNECRGTLEEYAKEVGVSYVPGKRPWCVKADIALPCATQNEIEAADAKTMVANGVKLVAEGANMPTTEEATEVLQKAGVMFAPGKASNAGGVAISGLEMSQNAARLAWCAEEVDSRLHDIMSSIHASCVKYGEQDGKVNYVNGANIAGFVKVADAMLALGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVU3</accession>
    <name>A0A088RVU3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_290800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700688.1">
        <property type="nucleotide sequence ID" value="XM_010702386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVU3"/>
    <dbReference type="GeneID" id="22576844"/>
    <dbReference type="KEGG" id="lpan:LPMP_290800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290012200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_290800"/>
    <dbReference type="eggNOG" id="ENOG502SIYS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266696at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="596" mass="62732" checksum="09DAC84D3B37E95E" modified="2014-11-26" version="1">MLTSTEEAYTHYLEHQVVADGVDAAIVRATLQQMGFDEKTVAAMMGDTSTYSLPFSTNSSASSTTSTLISSLKKPRRASGLSATTTPSAPSELADAAQFHRVITMPAESTAHAAAPVPAAAVPVTPAPSSIVHERCSTTDASHPYTFSHFATGAAAGAAPPSSSASSSTVPSSALSRTLVAGTVAGAVEGFVVERRSGAALSSWSNPELSVCGAEAKGRGAVTLLSRTSSSSLSEATVASAAQHGELTAAERASLARWMHEYQALMLSSALPRRASRSCADVPSFSTALLLSPEEAFDELPAAPSAVACSVRTENDECSAALQDETAAQPPLRWSEAADRVSRKVEDSDSSVAGSDGATSSNCSTFIRTEGGYSPYTGELLRQDGTDAAEKTQDGGAGWVSERYYRSAAARPLYRAAHAAAPSPTRRAVPKAKSPAFVPTCGICVPRCATGCIRCRFDVAQCRHPYREAQDVRIVRASHVAMTNNGEYEHRAIALSCCRARQFDAAQQTQHTARAQPTSGRRVPVMHAPIGASVQPRAGLASGRQASTLPVKTDRVRLAQYYRHQWEEQERRSSASGRSAAWNARYVLLSCAGWAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVZ5</accession>
    <name>A0A088RVZ5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_300950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701128.1">
        <property type="nucleotide sequence ID" value="XM_010702826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVZ5"/>
    <dbReference type="GeneID" id="22577149"/>
    <dbReference type="KEGG" id="lpan:LPMP_300950"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300014700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_300950"/>
    <dbReference type="eggNOG" id="ENOG502SMPJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="263674at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="359"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="476"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="359"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="401"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="492"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="514"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="674" mass="73107" checksum="D7B83809CA6B7C4A" modified="2014-11-26" version="1">MEGLPPPPPHEVHIDFFGIEGNTLHSPAPHDETPDGTAAAPPRAHSGEGRAALQRMRHSTPAVVPRSVAIHNDGNNTNSRPHAAIAKTRCSSARGAANGASPAGSRPSLTEMAASFPISVPMRDSIRHFHLLKSPHHSASNGSGAAAVNNERVADESDAGGATGRRPGMLLYEPLPHTRHRQASRSERKCSAITTAQFPVNTAVFASPEHPEEAVAPVAGTQEDVRCHVHVVLERHMTMLAAWEKRVFVAEVYRDKPVRTGGRPAPVRPQDRGFLEHIRRRLDNYLQQLEDAKSLLIQACEEVPPAKSGRQGDVKEWQSCCSRFYHTLSDFTIEESLMRFRVNKLLNVGQQEFTWRISARTTSSRGSSARASTRSRSRKASKSATTGQQPLSTGAGWHSCPAQSIHSAQSATATGAEASQLHIPTVTNGALSPYVRHLVLSGVVQRSNCAIKPGHGCITGPVQTGAVSEEQLCCPRPSGGCTPRRTNKSPTPSSAPALSQARQQQRLLSLHPDTVSQQPSRTSNRCGNQTPYGPLSPQRRTVSLRPVHSPTHPMVVLSALDDDAELCSATPSRSTLAVPSARLPTDAPLQLRTYSSPRGAATAKMTPCAAALQPFRHRQLLEVIERCEKNTATLQRGDLHRVRACFCELYGEQVGLQQYCQWIDDIFIEALHEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWA1</accession>
    <name>A0A088RWA1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab GDP dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_292190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Rab GDI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700823.1">
        <property type="nucleotide sequence ID" value="XM_010702521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWA1"/>
    <dbReference type="GeneID" id="22576982"/>
    <dbReference type="KEGG" id="lpan:LPMP_292190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290024000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_292190"/>
    <dbReference type="eggNOG" id="KOG1439">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9446342at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005093">
        <property type="term" value="F:Rab GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.405.10:FF:000001">
        <property type="entry name" value="Rab GDP dissociation inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000806">
        <property type="entry name" value="RabGDI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF8">
        <property type="entry name" value="RAB GDP DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00892">
        <property type="entry name" value="RABGDI"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="445" mass="49745" checksum="CD12FCFFEABA51BB" modified="2014-11-26" version="1">MEEKYDAIVCGTGLVECVLSGLLSVNGYKVLHVDRNPYYGGESASLNLEQLYQKFNKGPPPASMGRSHLYNVDLIPKVLMCAGELVKILRATVVDRYNMEFMLLDCSFVVKDGKIAKVPATEVEALSSPLMGFFEKRRLRSFLQYVSSYKVTDSRTYKGYNLRTMTMQQLFKEFDLGSDTITFVGHAMALQNNEGYLHKPALETVMRCKLYEDSFRMYCRSPYVYPLYGSGELPQAFSRLSAVYGGTYMLQTPVDKVNFDTNGVFESIESGGQKAFAKLVLGDPSYFPDRVKLCGKAVRCIAIMNHPIPNLKVTANACQIIIPQSELGRQNDVYILQLCEEDKVCPEGMYIVMIGTVVEHPENPKADLEAGLKLIGPTLETFISVSELYEPLEDGGTSRCFISKSYDAATHFEGAACDILDLFERIHGKPYSFEAIKRSGEEVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWA6</accession>
    <name>A0A088RWA6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="5">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_302250</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="5"/>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701248.1">
        <property type="nucleotide sequence ID" value="XM_010702946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWA6"/>
    <dbReference type="GeneID" id="22577278"/>
    <dbReference type="KEGG" id="lpan:LPMP_302250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300026800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_302250"/>
    <dbReference type="eggNOG" id="KOG0351">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF108">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="138"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="432"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="491"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="467"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="504"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIO00448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="998" mass="108153" checksum="C40C2EBE28F121D2" modified="2014-11-26" version="1">MSMNQVGFLHTQKRTRRDLLDCPMGGSRASDNVLISDASHGIAASLVSESNLALSKTLASSSAPPPAQSADSADDVSYLEQMLTEILDAAKTFASTIKEPSSASTQRDGDTLPACAYLLRTYFHFDTGAFKAHQQEVCLSILAGVNTLAVCPTGWGKSLCYQFPILVHRLLFECRYTRWCRQAAAATSALQQSSETAVKEGLIGSTSDAGPLPSTGLPAHLFSRFCVVVSPLLALMEDQAEKVNAIAHLNAFVLSSKVAADREAEVLAKLESPLCPLDVLFVSPEKFIASVALRRLLQSQAHRLALLCVDEVHCVSGWAYDFRPTFMYVSRVLRSPLLAYPAANAPEASPLMCARESLAAVPYLCLTATATKAVMQDIQASFGIAWTVTCGNQWRSNLELQVVDLVERHASFHHLPPASGDAAEAREPSARVLQDALLEAVQQLPKPMIVYVQSRADADALSGLLSSKCGQSHSPASGSRHGVFHVAPYPFPREQRSSVDQTESEDRGENSNEEHTDAPRGAETAVVIRSYHAALTRAMRSATQRQFLHGKIDVLVATIAFGMGVDKVNIRSVIHASAPSSIEGYVQEIGRAGRDGAPSICRLLYNPFDFYTLRCRLWGALLSPSEMHSIVCAILSGSTTHVGQRLMLVSVSTLSAELGFSEEVIETVIFLLLTATGVGASLADGLSTCAAPSRVPSPFKAVLGSYPLGYKVLRVQEEAERDRDPELASSAINATLHNRATPLKRRRTGARVAVGGSSTAAGVGLLLRQLGATDAVLELCRVSPNMLNQIEMANRLSMPLGEFQQRMQDLVETGIVTVAKYGTPSALLLELADTFTEAASPTSQQALASHLLALHRGRLDAQVAGLRRMFGVLQHPTHKAIAEELSREPESCRTALESDHLAWRPPGRVMGKVKAVSLVNAFVEENRLRIHSTYEALRTLMGIRPRSLIQHGKYAGQLPLAQSWYVNSPYFGALRTFELSWVLQVLAPHHLDTPFRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWB4</accession>
    <name>A0A088RWB4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_271760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700261.1">
        <property type="nucleotide sequence ID" value="XM_010701959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWB4"/>
    <dbReference type="GeneID" id="22576354"/>
    <dbReference type="KEGG" id="lpan:LPMP_271760"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270025400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_271760"/>
    <dbReference type="eggNOG" id="KOG1164">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5579860at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001132">
        <property type="entry name" value="Casein kinase I-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="96"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN99554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="559" mass="61366" checksum="2A88CF2D90092AFB" modified="2014-11-26" version="1">MTLTGRNAQAAHARDDVAAQVPLPPPPCPSMNVVVGAAIPLQQCHRHPYNNQPTQQHPQLGTTPSAVTNGGLLATEQQLQAPQPQQQQHSIFGGRFTLFDRLGSGGFGDVYRAEERDQPAPVAIKVERVTDSNALPEQSFLFHEAKVLQEIHKSIQAHAATPKPSQLMRLQPEQGQKGNGHRAENEASTAAGEARQERVGIAKLKYYGQDGMNRVLIMSLHGHSVANVHRQQERLSLFATVMIVDQVLSSLEHVHRAGYVHADLKPENILFGREDQEQLYLVDFGLSVCFRDRNGKHRPLIKNHSFIGTPRYASLRTHMGYTLSRRDDIEQLVYVMIYLFRGRLPWSGLRIHDPDAKEKRIAQMKADMPLDLICAGCPEAFRDVLNYARCMEFEEEPQYQFLHVLLCSLRDSCALELSSKPSCVSADGTGGVMPQMLMLNGDCSTHQLPKGRNSGDGIAGEGAVDVAAAGVELIKNTGIVSGVVDQIDGIAEIPMRMSSRGTGAPAFFSDAIGQGFLSGNGTDAGPLSARIDCLNDQSFPTPPLDLQLLCRSPQLRQMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWF7</accession>
    <name>A0A088RWF7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_272100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700296.1">
        <property type="nucleotide sequence ID" value="XM_010701994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWF7"/>
    <dbReference type="GeneID" id="22576388"/>
    <dbReference type="KEGG" id="lpan:LPMP_272100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270029300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_272100"/>
    <dbReference type="eggNOG" id="KOG0109">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="79941at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="4"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="142"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="246"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="321"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="110"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="205"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="334"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="334"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="377"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN99589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="407" mass="44536" checksum="2A6BB566C99DF0C7" modified="2014-11-26" version="1">MSACTVYVTGMPASATEDDIFDFFTRIGNVAEVHMPSTEQQQQQQPTSGIAPTVEVVFDKPEDAVSAVSISGSDFQEDIPIYISAVAPTAAAMGEPEVLAKTPAADAVGDTNGNATAAAAPAEPGTSLPVRRSAETERTSKNKILVTSIFPHTTRAQLRDAFGACGAICDLHLIPARHMAFVGYVTDEAYKKALKLDGTNVNGSPVVVRPCPPRDDASAPASRRDASRHGNDGAGASGPKRRALDVRVVVHGVPSDVTKEALRAFFSPDCGPITDVYVKPEIGVAFVAFTSAENAKRAISKSGETFMGTRVKVEQRLPLICRRCDKEGHVAAQCKEHSRDSQRYSNERHRRRRSSSSSSDRDRRRRRRSDSLDCDRRRHSRSRSPPRRRRHSRSPPRHRRQKESKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWF9</accession>
    <name>A0A088RWF9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Calcium-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_301290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_010702857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWF9"/>
    <dbReference type="GeneID" id="22577183"/>
    <dbReference type="KEGG" id="lpan:LPMP_301290"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300017900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_301290"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="444540at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051581">
        <property type="entry name" value="Ca-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34524">
        <property type="entry name" value="CALCYPHOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34524:SF16">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
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    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="307"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO00359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="413" mass="46571" checksum="9AE139C090159F44" modified="2014-11-26" version="1">MSVRMDASLYSDVARIERGDYLRFHCELLSANGRDTQRYFFGCYYPRWHGFYLEEVRSIIGNMGYPELKHFSAYPFDVYLKSADVAEAKHSAQSFEVDCANTTTYTTDDFLVDNIIVLGPPQNQRDDAVKRFKIVSVDVSHLKTKTFSLAPVANLNSSSINNPDTMLSTLRAPGGERVPVRLSREVLDVLTQLRGAYIDHAGGGIPEIGIKAMGRPFRKVSDDGRRWMTRGGVRQLVCHSRAFGADAGCLSGTRQAQQTIDEVTDTIFSAFPHEGATHPIAPGEEACEERIDYDVFMDYVRGHMNSTRKKAVLEVFQQLDYDSDGNITIKDIQATFNAQEHPVVVCDAIFTAEKLLRGFLAIWDENQHHFGLVPYTEFVDYYNGLSAVIEDDTVFLAILKTTWKVPNWTIKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWM8</accession>
    <name>A0A088RWM8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_301190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701151.1">
        <property type="nucleotide sequence ID" value="XM_010702849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWM8"/>
    <dbReference type="GeneID" id="22577173"/>
    <dbReference type="KEGG" id="lpan:LPMP_301190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300017000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_301190"/>
    <dbReference type="eggNOG" id="ENOG502SJM4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264748at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="183" mass="20630" checksum="3D4A3984933AB950" modified="2014-11-26" version="1">MQIMSLRELVVLFDTQLQQLTLSYLAGGFFALQTTVVSIATLVVCSSLALATSSGAGSSAVLFTQTPLLFTSFTSFVSLSVLTLMILTLFYRVVGGRFLYSPRETRYVVDWILDTISRPAMEETVRLLLSPNKRRERCIFFTGLCLVGEVGKLLSFWTLCTLVSMVWCGWSVRRTWYQYQWAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXB0</accession>
    <name>A0A088RXB0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_303540</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701376.1">
        <property type="nucleotide sequence ID" value="XM_010703074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXB0"/>
    <dbReference type="GeneID" id="22577407"/>
    <dbReference type="KEGG" id="lpan:LPMP_303540"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300040300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_303540"/>
    <dbReference type="eggNOG" id="KOG1290">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2649at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14136">
        <property type="entry name" value="STKc_SRPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000275">
        <property type="entry name" value="SRSF protein kinase 2 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000322">
        <property type="entry name" value="Uncharacterized protein, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="156"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="94"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="347"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="563"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="671"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="347"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="567"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="588"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="683"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="699"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="721"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="731"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIO00576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="742" mass="84614" checksum="4E49AF4A3D3272DA" modified="2014-11-26" version="1">MGKSKKHGKPAKGVLKRGNKNDKCKRKAKFIDPASSVSRDVRESVEALVEEIEREELVVEPQPLIKAKKKRQELAEKESVLFKSGMTKEQAHTITNKLQQQGTTHRSEGEGDEESNDGDGGGTEEDYSDTANEPSREYRKGGYHHVVIGEVYNDRYRVVKKLGWGYFSTVWLVWDYLKERYQAMKIQKSAASYSEAAYDEIKLLTEIMEADPHKTRCCARLNDYFKHTGPNGTHVCMLFDVYGENLLSLMERYEYRGIPLPIVKCIARQVLIGLDHINSIDIIHTDLKPENVLLSTPKHSIISLMKHFHPPPLHQRPKLTERDPKTMTKSQRRRYYKKLAKEERKTPLCEKDGEHTSRGDERGTNENGDTDSELSKTDPEWEVERFHHVILADFGNSCWTYRQFTDEVQTRQYRCPEVILGESYSTSIDIWSCACMIFELITGQFLFDPKKGDDYSRDEDHLALMSELLGDLPESMRLGDGKYRSHYYNSKGVLRNIKDLQYWILEDVLHQRHKFTKKKAKEIADFLLPMLKYSPDTRATPAAMLRDHDAFFDIQEDDYAPLCFVDEGGDDEEGSASDDEEETDSDSSLDSYSSSYSSERKANRSRQLNNGADRSEAFRYWEEHPILNRTYLEERGLTIADVQSVLAGNFLDDAATHKAAAEVIRLLSEEADRLSSDRGSAGDEADNEDEDDSSDDDKESTQDSEKPVEVAVDGVACSNHGVEEGKADSTDKEDEESDDGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXQ8</accession>
    <name>A0A088RXQ8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heme-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_311080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701496.1">
        <property type="nucleotide sequence ID" value="XM_010703194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXQ8"/>
    <dbReference type="GeneID" id="22577534"/>
    <dbReference type="KEGG" id="lpan:LPMP_311080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310017600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_311080"/>
    <dbReference type="eggNOG" id="ENOG502SQ65">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="2">
        <location>
            <begin position="27"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="121" mass="13174" checksum="8C869448345D977B" modified="2014-11-26" version="1">MLPMGEPCMRISYKGSHYLVPMEFILRVHPGGQRLILPYVNQDITQAFVDAKHSDMAVRLLERWMEGAPAGQSRITSSSSAAAGESLPGRGNEGRYAQIIWNALVFGIAGASVTAAVLCRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYM6</accession>
    <name>A0A088RYM6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glucosamine-6-phosphate isomerase</fullName>
            <ecNumber evidence="6">3.5.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Glucosamine-6-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_323440</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12172"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:75989"/>
            <dbReference type="EC" id="3.5.99.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.6" evidence="6"/>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702028.1">
        <property type="nucleotide sequence ID" value="XM_010703726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYM6"/>
    <dbReference type="GeneID" id="22578085"/>
    <dbReference type="KEGG" id="lpan:LPMP_323440"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320040900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_323440"/>
    <dbReference type="eggNOG" id="KOG3148">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7663298at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004342">
        <property type="term" value="F:glucosamine-6-phosphate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006043">
        <property type="term" value="P:glucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01399">
        <property type="entry name" value="GlcN6P_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000002">
        <property type="entry name" value="Glucosamine-6-phosphate deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01241">
        <property type="entry name" value="GlcN6P_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004547">
        <property type="entry name" value="Glucosamine6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018321">
        <property type="entry name" value="Glucosamine6P_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00502">
        <property type="entry name" value="nagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280:SF5">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01161">
        <property type="entry name" value="GLC_GALNAC_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="7">
        <location>
            <begin position="8"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO01228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="279" mass="31318" checksum="B8477300A42BCBF5" modified="2014-11-26" version="1">MRIVISETADQVADYASKYVIASINDFKPTEDRPFVLGLPTGETPMRTYQKLIVAYREGRVTFKNVVTFNMDEYVGLPADHPESYHYFMKHNFFNYVDIPEKNRHILNGNAPDLIEECRQYEEKIKAAGGIHLFLAGIGTDGHLAFNEPGSSLYSHTRVKSLNAETMKSNARFFGNDVSRVPTMALTVGLRTIMDAKVVLMMATGASKALAVARCVEGGITHMCTATMLQMHPAAVLCLDEDATLELKVRTTRYFKSLLRTEKALEERQKNIKRADSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYN8</accession>
    <name>A0A088RYN8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_322200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family. ADAT3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701904.1">
        <property type="nucleotide sequence ID" value="XM_010703602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYN8"/>
    <dbReference type="GeneID" id="22577961"/>
    <dbReference type="KEGG" id="lpan:LPMP_322200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320027600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_322200"/>
    <dbReference type="eggNOG" id="KOG2771">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3180714at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF156">
        <property type="entry name" value="INACTIVE TRNA-SPECIFIC ADENOSINE DEAMINASE-LIKE PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="4">
        <location>
            <begin position="407"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO01104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="539" mass="57383" checksum="47410CB8C989A45A" modified="2014-11-26" version="1">MREIIAAEPPFTCTPALVLIVSEPKHAQTLLRAANLHFPLDDTEGAHLKRLRPHHSAAPSPATEALPAQLATPSSSLELLLALQPLATCAALHPTPVSASNAPFSYAISGTSDNSSAVESSCASLTHQLLWPLSRADESLSADQVLELLSSDFASTSKVARFCAFVETASAVVSGNSAACVLRQQAICIPNCSDDADGCTPTPNSSHRGDETAPTSAAAAACCPLAFQIVPVSATAPRLDPAEWASANRVWPLAVPRPHSPTQPPPQWVAEVCKNMVRHVFPLCQGLRRVCEARNEKAHGSGLSLEGDVGESSKVTSSPQTRMTEEVVLGEEESHRLLDIVAVVIDPSTGLILATSSGCESMRADNPVAAAPYCGVVREAPHGEGPNSWKQRRAAAPQHPCLILDHPVMYALKQLAATQQQQEHQRQTRQASDDMVETISAPGSLALGPSSAVTAEASRYVGSVRAYLANGLDMYVTHEPCVMCAMALVHSRIQRVFFLFRNSVHGGLGGRYHVHSIASLNHHFRAYECTEAAALYAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYV9</accession>
    <name>A0A088RYV9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_302720</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701295.1">
        <property type="nucleotide sequence ID" value="XM_010702993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYV9"/>
    <dbReference type="GeneID" id="22577325"/>
    <dbReference type="KEGG" id="lpan:LPMP_302720"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300031800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_302720"/>
    <dbReference type="eggNOG" id="ENOG502SHQ5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16465">
        <property type="entry name" value="NUCLEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16465:SF0">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="294"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="294"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="130"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="247"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO00495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="468" mass="49763" checksum="3006694BED8B7ECB" modified="2014-11-26" version="1">MGGETMVNELPSTTCLSSELCDAFSEYLERAYPHPGPFSRNKTAQVLSAFTGVSVHFITTALASSAACETATVSKAELRLALEALMRIDGGTDAWWESPDVTMLEFTGPVNQEARDAADSRADIGVKSLTSAHARSHRPSPPNSTSREGPPDSEMGAGSRQPSLRPTLNSWGSRGSRLSDTCSLPGVSLPRPHNTAASMECVVAAAMGELDMFIEDEQCSIQFHPGRLSLRFSSEVPNEAERFGTLAQQGRRVGDRSCSPSPAHPAGEQAVRPSCPPIAPTLTLAELDRFVHRGKTSKVCKQFVQTGRCTFGARCLYHHPSTAAMTPNELHAVPRHLPEDAPKPVGSCIASATARGASLHRSLTAPMPGSFLKDALSRSAWLYVFPVPPITPAYLSEQVEAATMTEREREESCSTVSPPSLAGAAPAALLNLTVRPSGVQAPLAHSLLPQKGSSARAMPQSTPPLLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYY2</accession>
    <name>A0A088RYY2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF2817 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_302930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00515.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701315.1">
        <property type="nucleotide sequence ID" value="XM_010703013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYY2"/>
    <dbReference type="GeneID" id="22577346"/>
    <dbReference type="KEGG" id="lpan:LPMP_302930"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300034000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_302930"/>
    <dbReference type="eggNOG" id="ENOG502RV57">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270449at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="CDD" id="cd06233">
        <property type="entry name" value="M14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021259">
        <property type="entry name" value="DUF2817"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10994">
        <property type="entry name" value="DUF2817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO00515.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="408" mass="45515" checksum="1E3F5410DC767835" modified="2026-01-28" version="2">MAVPCDYVFSTLLVILTGLLFIDLVPLQETMRCSGDYANATQCPEVYYSSSYQLARERFLAAAKTAHAEIEHHLITKRGNVEYYMDTAFFPGKRKAKLLMHTSGTHGVEGYTGSAIQVKLLQAWNKTSLSGPSVLFVHAVNPHGMAHFRRFNEENVDLNRNYLSTEEWAAVKTRVANATGYEDFRTLFVPSAPPRFIDRYVFLYTAAKTLMRHRFIKVKRAFVTGQYHDPVGINYGGEKEQKSISVLRKVLKKHAAATGATEAIYIDVHTGLGPTGVDTMIVKDGRDYEKCSTVFPGVRIGNSQTATSGPSSGYDLAAGIIHPVAELGPNTLAVMEEFGTVNPLYVARAMVLENAAYQLCRGSYTHTVMQSWMRDAFYPQEISFKHATLKRGSSAFWSAWTYLAENQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZ81</accession>
    <name>A0A088RZ81_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HEAT repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_331710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702263.1">
        <property type="nucleotide sequence ID" value="XM_010703961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZ81"/>
    <dbReference type="GeneID" id="22578324"/>
    <dbReference type="KEGG" id="lpan:LPMP_331710"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330023900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_331710"/>
    <dbReference type="eggNOG" id="ENOG502QRXT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052623">
        <property type="entry name" value="DAAF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056497">
        <property type="entry name" value="HEAT_DAAF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057978">
        <property type="entry name" value="TPR_DAAF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16216">
        <property type="entry name" value="DYNEIN ASSEMBLY FACTOR 5, AXONEMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16216:SF2">
        <property type="entry name" value="DYNEIN AXONEMAL ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24573">
        <property type="entry name" value="HEAT_DAAF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25757">
        <property type="entry name" value="TPR_DNAAF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein axonemal assembly factor 5 TPR repeats" evidence="2">
        <location>
            <begin position="11"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein axonemal assembly factor 5 HEAT-repeat" evidence="1">
        <location>
            <begin position="331"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="905" mass="101186" checksum="CE30CA0C44319A2C" modified="2014-11-26" version="1">MDLLPKYLNELQDSNKMKRCAGYKKIHDLVKIQKGKLSKDDEFSIIRSCLKGFEDASERSREEAAQITIELLPGQDASILDWVLPSVVTRIGVVPVAEESEEIRLLLLRLGAACMTYFPHDIGARNYIDFFLVLLENCFRDPFPDLKKEACKATCQLCSIEPKQVKAISIPLTKVLKDSCLLHKHSAVRCEAAQTLTVLFRCGASEALKDGKNDPESRTMASELFVLCNDHSEPVRLAVLSVLSCALLDVKERLEMHAKYLPHLLILVTDPFDAVRNMAHKILEQVGQLYMIDNEDNRIDMANRRITMKDIEWYGDDEYPSMTFTTPSAEHYEIVQRRPSLGTRYAVADSVRGFLEKILGDITAVDWVIPFSTNNRKVVALKLLWTTIYYCEKSCVQFTERILNAVYKAFADENVEVKQEATFCIEMLGKFLVPEQYLPFLIAKPAANADPYADVSVIERSRNKTVVLTSLDDSCRVTPTLFSTAAVTVKCSILQALAYLIEGSKEKLTPGHSTLIIQALTTSDLIECENEHLLTALLATLQKVISVFVARGFIASPERPHPKEVLCDPKQRTLDSIILHSLLRIKSTEIPVVQLKAGEVITMLSTLVTGSLTGIHTLHVGRLLSRYGAALPVSAFSDLVLNADSVGTLGRVLTNIFESRLTDVNFAVKVTEELRYFTVLEKLLWCRTEAFGPSEVTELLRAVVLPLATFQPGNTAHLFRKVAVNCLCALLDPVYCDTLQEELVKNSSVLSTTIINTWCAASDADDGEMRLVCMSVLGEVCRLPMLKGAAHEIIQSVLLRFDDSNDFIRLRTSNELIRLLADDWGASPFIVEELSAQVVPLVKKMLVYLDDTEETIGIRPSLAGALKRLGDISPHIVVDLTRSALGRHMERCYCQDVLNYLETKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZD9</accession>
    <name>A0A088RZD9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_330810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702174.1">
        <property type="nucleotide sequence ID" value="XM_010703872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZD9"/>
    <dbReference type="GeneID" id="22578234"/>
    <dbReference type="KEGG" id="lpan:LPMP_330810"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330012600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_330810"/>
    <dbReference type="eggNOG" id="ENOG502SFP8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273829at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="396" mass="41665" checksum="882501836BB5F7C1" modified="2014-11-26" version="1">MSLFDVDSSCSFSDASSSSSDEGTLPTCPPPPPLATYDSLPSVAKSGTIASCAAPLSALEQRRHMAQLDAARQRNRGVLWRNELLGSPAVDLKGVIAGASSVQVERTYATSDPGKFGNSIAAALNLRREEREKALLKRLQQQRKAEEEGSDGQALAEKDVEVGVFVTAAYKALLRRSLHPAGRNIGDQGAQLLTKANYDNGEGSDDDNDGPLGVYLRQLEGTVHPATHTNSAPPSASQLTTGDYYECIMKAPLLEEKNASGTAVAVARSGGSTGDGTEALPAVALSMEGSDLTSLTAPTLRETQDLIKHRAAGSSPTPGSLNVPQTDVEETKGDVKPAVATEGEADDVHSAVLTHARLLFDARQSKNYRGVNHATLVAAARRCDERIGTSLFASLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0J7</accession>
    <name>A0A088S0J7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein kinase, putative</fullName>
            <ecNumber evidence="8">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_343020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="8"/>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702728.1">
        <property type="nucleotide sequence ID" value="XM_010704426.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22578807"/>
    <dbReference type="KEGG" id="lpan:LPMP_343020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340036600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_343020"/>
    <dbReference type="eggNOG" id="KOG0198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF56">
        <property type="entry name" value="MAPKK KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="590"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="642"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="1572"/>
            <end position="1862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="221"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="424"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1224"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1425"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="284"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO01928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1864" mass="200868" checksum="49383F83033B3749" modified="2014-11-26" version="1">MEHGDFDAMTPHSPCTRSMASSRHIDKDTEDTRGQDEMQRGRDMANGVSTPRRQLSHDGMDEIISTVSGRHMQQQSEKELDRGPPAVVVSRNAISAFPHQSSSSLVSFITPSSSSQMIPGSIPSESVVLSTQLVGQRGPHRHVRPLNKVSSLGNEQVYSHEDRSPSHYTMASYSSGGAGVSQEVDNLAELGNTPCPTPFGRRFTQLEPPLPQVTLNSRLASARSTPADGTGTSSGSQETRASSKWSTASRHCYVPGRASRLHSGTSVSDGGGGPFIALLSTTSRATTQASQPTTRGPNESLHGLDTSDTRASLLSLTSETVSTSEWTTLTPVRHRDEYVMHRTSLPPPPSMRTRTFIHARAMAPTLLAPGMYTSTRLMPSALMVSTSLAVEPQHLEPYFITRNPLTKQQRLSDKDLGGHATASFQFYDGDTPGTAVTPRAHYADRRSPLLRGCAGTGRGESRTPPIAVLVPLAPEPAAPASASPLPMQQLEGETYEVNASSLSSERSWCYEELPSPRPHRQEPAPAPESRASVCVSPLHPSLSHVFLPSPELPLSRSTPAHSSPPCNDDPTLLEYVAGLKPPRGSCSIRGGLLCVGGTLCVMPLCAVVLLFSLHYWAVTLQESSYATVVLRPHVGGMTAESALVLGILLAFLVMGGGGGVILYAVLYRLAIRCHLRAFALCVRLADAPSPLDIHHLAVEDSGGRCDSAMPIDAAAAAVQKSANDSTHVSSFSPFAVRWHEEVSRLVNNLTCAIEVNQAEWRSFLASERRSLVMPHEDANWISDCPVVATTPTDGPFCSSNNSRSLPCGVQPSAPTAEKESWSLCGTQRGSRYRMSEAVFSRRPQHPVDVSKRQESVTVVVCRLMVPTELLVQQSPLTRAQLEELQRLSNEFHQRLRAVPRTSYAAITEVSVSEVVFSFNTVSPLPSLVASPAAVALAVAASKALVEWRPTYLGTSVRWGIAVHRFDAYTCPTRGTQGRLYVSFGTVEYDFARLLAELAALFDYGALCHAGFLADASCESQSLPVDYVMDLRQQAFLVYQLHDGDVDRKQRAQMNRAIAAMRNGEYKAAADALEAWSRKSGSCGIFARAAAHLRYVAGFLERAARQRRPHVLEGKVASESSPSFLLSIEGVAEWAAESLLTSYFRPPPVWEEEEEAPIAPRMSNPDRLRAPFILSTSGGGGGCSSGTGESCRSNVAVLPPALPRDCSAGELATFLQALMHRSSPARIPYESPTPQREGPTGPRAIQESLHRPCEVAIALEADAGPLNSLPRNDEPLSSATQSVCRGGNVLESGSAPLSLRDNAAGCSSLSPATRCVFEMSTPTTALPDMSNGDQMWAALASPTEPDLGSVTMTAQRPHLFSNSWSLAESGVPEMLTLTPLTSGVLLPSQSDVCRQRQASVLLPAPKNEEAAAAAVACMSAMGSTAARSSRGRCDSGGNKSHQTHGRNGFQPVTEVPASDEWSPRPLGQHASSQSIDTTIARLTSDASHESVLARSGSARRRASVSTAAVSSVLPLFSGSTVPFSVQEKIEARSEVDISSEVDPNQELSMMSVAQHSRSRLSQRATAQPSSVVCSCTRRIDRSLSDKVMVFQGFHPDGYLVAVKRADRRAEKQVSLLRHEVDLLREVHHRNVVNIVSAWKDDNAEYFAMEYACETLATVLQKFKVLLPGVVRFYARELLNALVYLHRDCGIIHRDLSPNNVIITNTTDRSRVKLIDFGRSVMTPHLRSGSGGLSVAVPSSASLELAESHSSRSKSSGTDVTLSVAGTPLFMSPQACQGLLHPTSDIWSLGIIVHLCLTGTYPYPPETFTDPETFIANVGSGKLTPVLVDTCEMTGEARDFIEQCLTLSHTSRSSAVALLKHSFVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0N4</accession>
    <name>A0A088S0N4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L32</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_341880</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702614.1">
        <property type="nucleotide sequence ID" value="XM_010704312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0N4"/>
    <dbReference type="GeneID" id="22578693"/>
    <dbReference type="KEGG" id="lpan:LPMP_341880"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340024800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_341880"/>
    <dbReference type="eggNOG" id="KOG0878">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268693at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00513">
        <property type="entry name" value="Ribosomal_L32_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001515">
        <property type="entry name" value="Ribosomal_eL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036351">
        <property type="entry name" value="Ribosomal_eL32_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L32 AND DNA-DIRECTED RNA POLYMERASE II, SUBUNIT N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01655">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01393">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52042">
        <property type="entry name" value="Ribosomal protein L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO01814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="133" mass="15366" checksum="C6773CE89C464E02" modified="2014-11-26" version="1">MVKPVVKKSVVKKRTKRFTRHRYELFPQLSSSWRKPRGEDSPVRRRYKGQKAMPNKGYGSDRATKYIMPSGFKSFPIQNVQDLYMLIMQNRKYAGVISHTVGAKSRKAIVRKALELDVRLINGSAKLRKVANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1I2</accession>
    <name>A0A088S1I2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_344900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702909.1">
        <property type="nucleotide sequence ID" value="XM_010704607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1I2"/>
    <dbReference type="GeneID" id="22578995"/>
    <dbReference type="KEGG" id="lpan:LPMP_344900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340056900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_344900"/>
    <dbReference type="eggNOG" id="ENOG502S1E5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="72851at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO02109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="168" mass="19154" checksum="97ACC3E40025D5A8" modified="2014-11-26" version="1">MSEHSSDDEDVVVLQVCANRHCQGIDDLEFDEETNQSYCGRCRALHARTETEGFRILLSNDDLDLVKLIFGKFDQKSRGFWTYKEWNAFQEVTDRGSDDPIESPSALKEFFKEEYDIDISPHGKDGAVVLLVDLENMYGGYLYNNVDALVEDSETMEDQGLLHTGVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1L5</accession>
    <name>A0A088S1L5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N-acetyltransferase subunit Nat1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_351350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703073.1">
        <property type="nucleotide sequence ID" value="XM_010704771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1L5"/>
    <dbReference type="GeneID" id="22579164"/>
    <dbReference type="KEGG" id="lpan:LPMP_351350"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350019100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_351350"/>
    <dbReference type="eggNOG" id="KOG1156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10263032at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1010:FF:000004">
        <property type="entry name" value="N-acetyltransferase subunit Nat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1040:FF:000009">
        <property type="entry name" value="N-acetyltransferase subunit Nat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1010">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021183">
        <property type="entry name" value="NatA_aux_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF2">
        <property type="entry name" value="N(ALPHA)-ACETYLTRANSFERASE 15_16, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12569">
        <property type="entry name" value="NatA_aux_su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000422">
        <property type="entry name" value="N-terminal-AcTrfase-A_aux_su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="46"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="80"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO02273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="711" mass="81341" checksum="180980208CC9F6D6" modified="2014-11-26" version="1">MSLAPSTLPADQQRLFDRMNREYSNREYSKALRTSESILSIVPDHVDTFAGRGLVLYNMDRQEEGYESIKQAILLNPKSMVAWHALGMCQRLDKKFGEALKAFKRALTFDPTNTEVLRDLASVCIQLRDWPLFLEAREKMVMAKASVRANWVALSCGHRILGHSRIAAAVMDTMASIMDTGDTPVEVSEAQLYRVELELESGAPQRALELLKKHDIDIIDVETKLLLRAKAHAQLGQRSEAEKRYMEVIAMGVSEADSIAALAHLQKIPLDRYLRPAVGYTEKYMEIIDRVLKAYPKCDYAKRHALDCGPIGEFSERLAVFVTPYIQRMIPSLFSVLKSLYVDAERAAKMGDFFAALEQELEAKDFSRFGGEASPCYILWVRTFLASHYRRTGDYALAHAYIEKAIAHTPTLELLYLEKAKILAREGKTAEAAEQADMARRLDLQDKYLNSKAAKYYFRDNQVEKGEATMQLFYKPSVVAGDTYLTALESQCYWYEREVGEAFYRKGDYISALQNLLMFERHHEQNHCELSDFHNYVFRRNTMRPWFDVLDCDDNMGRNKFFLKFCPAIVRTYMRIHENGEEAVRAAHVPRPELKFDEVAAGEVKRVKQLHADYYMSDVDLSEPLVKASRYMGHLLDHRNAEASTHTLAIELYTAADKPLLVARALLALHRQQYNKARDLVMAFKTGMYTTTTMDPRVRAIVDEILTIVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1M4</accession>
    <name>A0A088S1M4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_331730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702265.1">
        <property type="nucleotide sequence ID" value="XM_010703963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1M4"/>
    <dbReference type="GeneID" id="22578326"/>
    <dbReference type="KEGG" id="lpan:LPMP_331730"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330024200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_331730"/>
    <dbReference type="eggNOG" id="ENOG502S8FF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20282at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22860">
        <property type="entry name" value="PDRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030482">
        <property type="entry name" value="PDRG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21162">
        <property type="entry name" value="P53 AND DNA DAMAGE-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21162:SF0">
        <property type="entry name" value="P53 AND DNA DAMAGE-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="72"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO01465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="123" mass="14255" checksum="F107032363A4B0FB" modified="2014-11-26" version="1">MKTDRNTERINIEVAAEEVTEAKQYLIDLDRRKNQYREAQRKIITKRPEEDLWILSGGSTFVSCELSHSDTLKYFEWRLQQCDNEIEEAREDLKLKVAALAELEGADSALARLYEGFDLKGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1U0</accession>
    <name>A0A088S1U0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_332430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702335.1">
        <property type="nucleotide sequence ID" value="XM_010704033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1U0"/>
    <dbReference type="GeneID" id="22578396"/>
    <dbReference type="KEGG" id="lpan:LPMP_332430"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330032000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_332430"/>
    <dbReference type="eggNOG" id="ENOG502S0T6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277340at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="525" mass="56636" checksum="E3A377F04D028C21" modified="2014-11-26" version="1">MLKTASQRVASGASTEAASACMRNTSHAAAALAIALGAHRLLFLQRRHRALGMSGCGEAAGPYFQALQCGRAFVKSRSLSPDDPFGERSSWEDPSDGIYSAWKDVDQEGFVKAADSREVREAHFGPEWARFSTVGRMSVKKMRADQKLHHAPQSEAAGGEPQGAGVAVAASGSSTERYPTTEELHEADLRQRRRLLERNYSSYEAFVEHEIGGGDGFAGTNEDLTSVSEARMHRSGAKAELYSAASMESAFSAVGGLDGRDRMTQRNVEREALETLEAAEVAERVPLPSFMFDPDIRDDATTSALSLTNPIPTITSASTAAEISRSTAATSFFAEEPCSTTNSSSELTVPSVSATAGGTPANVVRQVLGVLGSPHGDSRLPLTDPMEWGTEDIILFLTLMEKPSRSVEAGSLPALSACSTMDDAMCGTFRMARVTGETLLNVVVPPRLFRLMRQWHVRRQDVVNKAWKLHGQAMRTPATATDGHLPGDIVQTAVLQGCERLEEVVQQLDCTLIQETILLCFPYGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S203</accession>
    <name>A0A088S203_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ABCG6</name>
        <name evidence="10" type="ORF">LPMP_352960</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703233.1">
        <property type="nucleotide sequence ID" value="XM_010704931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S203"/>
    <dbReference type="GeneID" id="22579325"/>
    <dbReference type="KEGG" id="lpan:LPMP_352960"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350037000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_352960"/>
    <dbReference type="eggNOG" id="KOG0061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="184675at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000903">
        <property type="entry name" value="ABC transporter G family member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF139">
        <property type="entry name" value="PROTEIN SCARLET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="498"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="530"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="566"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="649"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="40"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIO02433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="680" mass="74467" checksum="2915D56CEAFE9873" modified="2014-11-26" version="1">MSSPAPPTVRADAGLLRHLSHTSPKSFMPPPASSQHKTVLTWEDVSYTIGSTEEGDSRTLIRHVSGYAQSGEMLAVLGPSGAGKTTLLDILAQRKMGGKGRITGSILLNGAPIESTAFRRCSGYVQQDDLMHSYVTVEEAVRFSATLRTPQTVSTEELEMRVSRVLRQLGIDHVRHNCIGSALVRGISGGERKRCAVAVEMVTSPPLLFLDEPTTGLDTFTALHLLTLLRSLSRSGVAIIFSIHQPRFRIYETFDRILLLNGVGEEAYFGPAADAMGFLAQIGLSPSYVGNPADYLIDAVSVLPVEEEEWLSHQQQQSVAVETMTDGSQLILPPPPASSKERLERLSSAASTQSRDIAAAFASLRLAAVLRQINKLQRSSRAASLTLTTTESPARAYYRSWPTQVSCIAMRYLRNRRRDPVATYVSITSAIVFAFLTGTIYYQVGNSQDSIRSRMGVLFFIMMISTFSSLGSLEMFLTDRAIYAREHRNGMYSTSAYYVGKVIQDIPIGVLVTFAFNVIVYFLVGLQHTVAKFLIFNGVSALVMLNGYALCLLMSNLAKDYSTANILTSLLLVLYLLPTGGMLVSLNNIPLVWSWIKYVSFDRFAFSALVANEFEGLSLVCEPVPSDLVPCITSGSAYAASQGMYAKDIGPHALIVMISMVVYLVLGYLVLRCWRSTEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2A8</accession>
    <name>A0A088S2A8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear pore protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_352570</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the nucleoporin interacting component (NIC) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703194.1">
        <property type="nucleotide sequence ID" value="XM_010704892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2A8"/>
    <dbReference type="GeneID" id="22579286"/>
    <dbReference type="KEGG" id="lpan:LPMP_352570"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350032300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_352570"/>
    <dbReference type="eggNOG" id="ENOG502RCAN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="244971at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007231">
        <property type="entry name" value="Nucleoporin_int_Nup93/Nic96"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11225:SF4">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11225">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP93 NUCLEOPORIN NUP93 DEAD EYE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04097">
        <property type="entry name" value="Nic96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="4" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO02394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="900" mass="97503" checksum="3F36A230FDA557E6" modified="2014-11-26" version="1">MFSSTSTIAPRRLGSAGPGGDDASALRVMPSTGDPTDEVRASLASLTARAQRLVAERNAEQLLRNGFGLFEASRKAAEKARHQASKCQSTSEGYAPATHASVELFMTQHLGFDAQAQQRLLLQLQHRHAQLGVDLGPIDALPDTEASGFMGIADVDAVVAELKNDILLDVQHAVHRRQTSIVRDQVDTLFKAAWHPFYVRIADDYEALAMGASELACGKAGPSGRLSATDTAASSAHTFAGAGSGASKSLVDILNSGSALATELNRRIAAFAAIVEEYAPAQWVTHFTAYVTETSLNGRDDLTVLWASIVQIIEPMQRRGSEVDILSYVASSRRVMERKSLSRLLERMLRMDPIRFEEVENLSASHLLDIIARSCGATNHWMHAFVAMRVGRYDVAQLATDAIGIQSVRDAVAKVAAAPPAERNTMPPASDLQPVYAEAKTKEDPYRQAVLIVLLAGCTGENPAVVLRTLLNLAQRVTDSLEDALWLRLSCIRGVDKSAQVSPVQSLRTLQRAVLDDMQELVSITQGNAYRLASFFIHALLPSTGLRLLLENSITHVDGFHMTLCFNAQNLLQGRLHSALEAPIDIARHMSRYCSVVLLDVDRRIRATVFAGTAMFAYFHKSGLTEAFVECCLKDLICARLLGPRNTVGGYDSLLLRAGTGALSEELLKALIQVAEAASARSEVAKATHVLLAVACLANQLHRPELQQRALRRAVQMMSPALAQVLHLPSRSSVVSDVLSQAAQLQQAVNAVPHHLHDEAIGAQDYQTFAQLCRMADVYAFNVNGNVSDAVDAFLQLPFVPPPNTAVTGGVDAYVEAYCNAPGSVQLGASAALRVAISAAGQLLQYYARNSTGDSADVDDKRLRLLHRMQTVLEWARQCCARTSVAYPAVAEEFERAYLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2B4</accession>
    <name>A0A088S2B4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-dehydrosphinganine reductase</fullName>
            <ecNumber evidence="9">1.1.1.102</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_340310</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.102" evidence="9"/>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702460.1">
        <property type="nucleotide sequence ID" value="XM_010704158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2B4"/>
    <dbReference type="GeneID" id="22578535"/>
    <dbReference type="KEGG" id="lpan:LPMP_340310"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340008200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_340310"/>
    <dbReference type="eggNOG" id="KOG1210">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047560">
        <property type="term" value="F:3-dehydrosphinganine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006666">
        <property type="term" value="P:3-keto-sphinganine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08939">
        <property type="entry name" value="KDSR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000807">
        <property type="entry name" value="3-keto-dihydrosphingosine reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045022">
        <property type="entry name" value="KDSR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550:SF3">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0746">Sphingolipid metabolism</keyword>
    <feature type="domain" description="Ketoreductase" evidence="11">
        <location>
            <begin position="35"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIO01660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="339" mass="36170" checksum="884F8A0DBB49A193" modified="2014-11-26" version="1">MSTFFVAVAAVLGASLVLTALWAVQRIPRWEWESSTVLITGGSVGIGLATAKSLARKQVPFLILAARRECVLREAVQQVEKVVEECHSCTRVSYVTMDVADEVSVATGLARAKAQCDGRPVNLLICNAGFAHPARFVDSTMAHARQMMEVNYFGSLAVLWKVLPEMLEMKRGRVVLTSSMAARAPIAGYTLYSATKAGLRAFAHSLDMETSCLGVRVQVVSPPDVETPGYAHENEVKSPECAAISSFGGAKPFTAEAMAQSIVNGIGDYSFDITLGMDGIMLNYGSAGIEPATSVAALLTQSVLGGVLRLGLAVFSKIHYGIVRKVRLAEASSAPPSRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2D8</accession>
    <name>A0A088S2D8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Paraflagellar rod component, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_354350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703368.1">
        <property type="nucleotide sequence ID" value="XM_010705066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2D8"/>
    <dbReference type="GeneID" id="22579463"/>
    <dbReference type="KEGG" id="lpan:LPMP_354350"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350051600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_354350"/>
    <dbReference type="eggNOG" id="KOG4308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052201">
        <property type="entry name" value="LRR-containing_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111:SF0">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1079" mass="117673" checksum="088731FAE18B8BA0" modified="2014-11-26" version="1">MSEDLFKETLASLSKKGDGHIKCAKLDLNDHQLELLITALEHSPTDVKTVDVSNNSITSSSVACLVRFLETALVQSLDLHNNQIDEDGALQFLSLFEKETSIKLLDLRNNACSVATAARLYYLSKREKYPLAVRSTLLSGKASQISFSGMTYGDLEKELLQYLLQLEGLEAVDFSGLDLGPGGMFVVGTFLKDTQVSSLSFRECSLTNDAVLKFVEAADLAHHRSLRSFDFSSNMGLTNDLVRKLISSMFDHNSCITSFVLTATSITPAYCGVVQKECAVNQEHPAIKRAVVALRNNSSAAQEINLQWDAPLPTCMYHLADFIAASTAIQHLNISNTLVDDAGLKLLSDALQKNSTLKVIELANCHVTATGIQTLFVVLAKGKCAVEEVNIANNSLDDDSVQFITAALRANPKLTTLNVDVNPAISTASMQEMAGLTMVNRAPPRIRSVLPSIENNCKDVVSVDFSGNDVTLNDDSVWVLAQALRLNSTVRRLNLSHNSFGDMGASYLADYIASNSTMLELNLSSCTIGNRGAHRLCEALATNQTLQLLDLSNSMMDEDGLSALLRVLRENNTLRELKLERTRVPAEFVERVKIACSLNRECAAVKRVCYRLHDEDVSLKKIELSNPDDERVIDDLSVSTICTALNNNTFVEVIDLSGNHIGENGCAALAAMLSQCTCKVRTINLSKNPIDDDAVAKLLDGFPNTKTLREVLLYNTNITDLGIEILAKGLEKNQSIVWIGVANDDAVSEQVTLLKRNLALNTGPTELKHIILSIDAGAVLEDVDMSRPIDCSLDDSMCQFLCASLVGSRMLRSLKLSHNTLSSACVPYIVEVVELCPSLVSLDLSDNQIDQSGAQQIIACLERVSHLRSVDVTNNLFSPQSLERVSHLVSLNLGSEVLKKLHLATARGEALPKDIVLNGVTNSYKLTDEDVVILAGILQDCSAVKSLDLSSNNFSDAGCIAIAEVLRVNHALEALNLTGNAIGANGGAALYFALKVNPQLQHIWLENTAIPREILEDIASLLHVNQTPYRAVIDMRDVKLDEVSDETQFRSTDYYVAQTISLKNESIEGCMQAEVQPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2P6</accession>
    <name>A0A088S2P6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glycine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Diadenosine tetraphosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_353940</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="4"/>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703329.1">
        <property type="nucleotide sequence ID" value="XM_010705027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2P6"/>
    <dbReference type="GeneID" id="22579422"/>
    <dbReference type="KEGG" id="lpan:LPMP_353940"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350047400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_353940"/>
    <dbReference type="eggNOG" id="KOG2298">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="57698at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070150">
        <property type="term" value="P:mitochondrial glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.230:FF:000001">
        <property type="entry name" value="Glycine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000004">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000158">
        <property type="entry name" value="Glycyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000010">
        <property type="entry name" value="Glycyl-tRNA synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003211">
        <property type="entry name" value="PRK04173.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745:SF0">
        <property type="entry name" value="GLYCINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="GLYCYL-TRNA SYNTHETASE/DNA POLYMERASE SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="164"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIO02529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="627" mass="70390" checksum="D3B1130E6D74F120" modified="2014-11-26" version="1">MSAASLPAKLEGFVRSEFEDTCRRRFFYGLAFDPYGGTAGLYDLGPTMCAMKSNMLHFWRQHFVLEESMCEVDTTCLTPEEVFKASGHVTRFNDVMVRDTVTGECIRADKFLEEWSEAQIAKDGITAEQKDEFLHLLHDAAGMNPAQIKAVVERHAIKSPKGNTFSDPFPFNLMFATHIGPEGDRLGYLRPELAQGIILNFKRLMDSGNAQRMPFAGACIGTAFRNEIAPRSALIRVREFTLAEIEHFVNPNNKTHEKFNSVRDVEIWAWPRNLQANNEDPIRMKIGEAVDAKVIDNQTLGYFIGRVALFLESVGVRFYRFRQHQSTEMAHYAQDCWDAELLTSYGWIECVGIADRSAYDLTQHSNASKKDLCAREEYDEPRIERQLLRQLTKGLIGKTFGKRAGEVMEYLNTAPAEACEAVRAAHAAGQPATIALPSGEEVLITAQMVSFEEKDVRVTGYSYTPSVIEPSFGIGRILYCLLEQSYWVRRDDGGKNDKRAVFSFSPLLAPQKVALLPLMVKPDLLAIISEIRQELVMRGISVRVDDSSVTIGKKYARVDELGIPFAITCDFEGDGSVTLRERDTASQVRVPRSEVTSVVMELCNPLQPITWECVKAKYPAQTAAVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2W2</accession>
    <name>A0A088S2W2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">G-actin binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_355720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703503.1">
        <property type="nucleotide sequence ID" value="XM_010705201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2W2"/>
    <dbReference type="GeneID" id="22579600"/>
    <dbReference type="KEGG" id="lpan:LPMP_355720"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350065800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_355720"/>
    <dbReference type="eggNOG" id="KOG2675">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1601at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008179">
        <property type="term" value="F:adenylate cyclase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019933">
        <property type="term" value="P:cAMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001837">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013912">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036223">
        <property type="entry name" value="CAP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006599">
        <property type="entry name" value="CARP_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652:SF0">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08603">
        <property type="entry name" value="CAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00673">
        <property type="entry name" value="CARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69340">
        <property type="entry name" value="C-terminal domain of adenylylcyclase associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="3">
        <location>
            <begin position="97"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO02703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="265" mass="28565" checksum="6104D3B7B0AF124A" modified="2014-11-26" version="1">MPPPPPPPPPPPPANDGASSASVGGAAAAVFAEICQGGDNITARLRHITDDQKTYKQNIQHGEIDMSELERKKAAAEERRLAQKQNERTSGEGAVQTPVLALEGDKRWIVRYQAGSPAEQLPLVLDKAEMRHAVRIENCQHAYITITNKVNSVSIVNCAKVQVALQTIVSSLEVLSCADVDVQVTQAAPTIDIERSTSVNVYLLDHEQARKTEIVTACSSTVNVLFPSEKDGDIVECAIPEQFVTRLVSDGKGGDKVCTKPCDSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2X7</accession>
    <name>A0A088S2X7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_354330</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703366.1">
        <property type="nucleotide sequence ID" value="XM_010705064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2X7"/>
    <dbReference type="GeneID" id="22579461"/>
    <dbReference type="KEGG" id="lpan:LPMP_354330"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350051400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_354330"/>
    <dbReference type="eggNOG" id="KOG1539">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250769at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001108">
        <property type="entry name" value="WD_domain_-_G-beta_repeat/Utp21_specific_WD40_ass ociated_putative_domain_containing_protein_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001274">
        <property type="entry name" value="WD_domain_-_G-beta_repeat/Utp21_specific_WD40_ass ociated_putative_domain_containing_protein_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH_b-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059157">
        <property type="entry name" value="WDR36-Utp21_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007319">
        <property type="entry name" value="WDR36/Utp21_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840:SF12">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25171">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25168">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04192">
        <property type="entry name" value="Utp21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="Soluble quinoprotein glucose dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDR36/Utp21 N-terminal" evidence="7">
        <location>
            <begin position="31"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="237"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="500"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="591"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="WDR36/Utp21 C-terminal" evidence="6">
        <location>
            <begin position="777"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="700"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="705"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO02566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="987" mass="107346" checksum="1B878BB989B562E6" modified="2014-11-26" version="1">MQSFDPFRVVGSICGSVPVSPTLLYGTPVLMVATGRTFQLYKGKELAMMRGGPTFQDAVQAVAQAGKYRAVGEGPRLHVYVHHKPLWSSHHESATKPNITLLLAQDDLLFSVGEDKRIVVWELKTGTVLQEMLVEKSETVTCLALLTAYTNKLLLATAEGTLQLWNFRSGVCLWYSVRSCSGSGSSTVQTSRATAGSVAAITALACSRYKDIIVYGTTEGKAVVCNVAADEVITTFDHGDSGAVTSLLFRTDKDGLLVTGTSRGEVVVWNLENRCMDGTLTRSKQVRSELEALERPHVDVVHSLVMFDLPEYTSLLVTGGADNALMQFRFDTVDGLGVLVRERRGHMGSCTDAIFYNTDLLVTAGNDRALRVTHVFSDRASWELSQGKLGKRGRELNMGREAVKLPPAIALAASTTRNYQWSSLVSLHTASALACGWRMDSRAMEFKLSGIQTSAHTARALALSDCGNYAVVGYSSGNVAVLSLQNRSVRHLFDAGLGADRAHDSSVECVEVACGNTVVVTAGLDGVIKMWDLWSGKLKATIPTGQPMTKSCLHESSSLFIVAQHFTIRVYHANPDAGLTEGELRVPVRELDGHNSPVTALALAPDTYRYVVSTSGDGALLIWDLAAAACVGQYRFVSPALSLSFHPDALFLVTTHAGERGAYLWVNNIRYGYVPEVVLAPKSNAVETLPWLHFPTAHGAAEGTSEGSANGGVQRTSATAALTEAEEEERAVAEAEEREAATTEACLFDASQDIALVRRRQIEAQQVALDAIATEGMQLADVPQRLWFNLTVLDQIKEKNQPLLPPKKKDVPFFLPTTQELRPTFLVLVSDNRKGDAENEKGRVMRADMEALTRVQEMLVNAKHDALMDYFLSLKTAQAIDLELKRAVDYVNGSSYTAAELARMQACVKGLLSFITTWLRRNQNVDLVQGILADVVRSHGALLTRFGDALVPALEELAEVQNMMRYSLDHLVSYPACLAGTFSGTIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S305</accession>
    <name>A0A088S305_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_080420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="AIN95851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704173.1">
        <property type="nucleotide sequence ID" value="XM_010705871.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22572504"/>
    <dbReference type="KEGG" id="lpan:LPMP_080420"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_080009200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_080420"/>
    <dbReference type="eggNOG" id="KOG0266">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2161379at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44464">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44464:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="439"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="611"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="660"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="703"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="977"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="977"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="990"/>
            <end position="999"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN95851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1401" mass="148335" checksum="C3D018981ABA6D35" modified="2014-11-26" version="1">MALSPIAYISPGCSAQCRQCVSAKANSFAFASVQGISLYRVSTTNVTIPTSTSSDPAQAQTQSLETIAVTDYPLGALFGHGVHASITAFSYNEDYMACLTPQNKQVLMWSLKDAETLTARKIGTTALADAFKREGNPSTMCLAGKYHVLCGTNTGRLISLNTNLDHAEPHSVVIPPSQHRVSVQQPRSPLSPKNPYSAVAAPGPFSALNPSCGSNTSAVAVESVECIAAATARPEVVACGTSDGTLCLLTLNASTGLLVTASLCPFPAKEKSETALDVNPLPVTSLAFDPTSAQYLVVGSQDGALALCDVSKNSMLQSFDVSKLAEKHVSSIAWIPGEAGAFYTASTDSPVLRKWSVSSKSAVGSVSILVALSQLPQRHSDAYGTADRSGSAVVEEGGSCRTGIRSVAVIDQARVVVGLTNGSVKVYDVAQQRLEFDIVTGHTDATLSCKLSKHDRDQAATGGVDGMIRVWNLRTLSQQCSIPVGPVMVHSVDWSPNGKHLIAALGSGEVVMYSTSTNRESWRTPVFSDLVYRVCWAASDSSLIAATSRSGVAVLSSKEGKVVRRYPAPRAAFYGVDIEPLKSKMMAAGSHDHRIYVYNLSSSSERPEHVLAGHTDAVCDVAYNPTAPSYLLSGSYDGTLRVWDLSSNDAHTISVSSRALKGHADRVRSVAWCSLAPYLVLSGSADATIRLWDIRNGVAITTVRGHNADVVAISSHVDRPLMFLSAARDSTLVAWNVALLRQVYLDAALGTLENCIAADPTSLMGVATSNVTVSQVAGAAVQRLAKELAECASKPAERLQKLVSFFECPNGAAEVAEMALYVVDPTAYKAAVTEGKTAATGLVVPAPSLPEAVRAHATYTSERAHSKSVNAAGPSYKKQRLLEAADELLRVGQLEAYCNVLLEAEEWDRAIAASPAISRAYWRRVCEKAAEAMEAAGDARAVTYYIIGEHAHKAAQLLTRLSQRHYDAATVVCQTCPQSTDDPQQQQQQASEPPHNTTVDANSVTAATQQLQRQRAAVLKRYANPQLFAAVLLAYGHHDEAVNILQRCGDVVLGHLLVHTVPLREQASIDTAFRLSMLQSARQQKWETALLCATRQSNAYDALATVLALFQTAQGKQLAGKTAAQSLTSGNLSTLHSVSERLKAFHEQVRGECAKLQLPLDAAAIQQRHAHDGLASQNQLAAMVLAADPSLGPMTDGVILQSLSGFMENLLTVALQDIDGANTPFYLRQAYNVSAYVSLPLDTPGKVGSNPSSSVTVPAVVSAMAPEHKRFLALVFIVAALITVKVYRFPKLLNSAFAKARELAAASGTASLSAVLANAQGALGTYSPHSKEVDSSSVGGTLPALSGEGRQIVSALTGDPVCGAVHVLEDGSSYISKSEALAWMLCSHFSPLASGARLTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S351</accession>
    <name>A0A088S351_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Replication factor C, subunit 5, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_356900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703618.1">
        <property type="nucleotide sequence ID" value="XM_010705316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S351"/>
    <dbReference type="GeneID" id="22579718"/>
    <dbReference type="KEGG" id="lpan:LPMP_356900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350078800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_356900"/>
    <dbReference type="eggNOG" id="KOG2035">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="761538at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000002">
        <property type="entry name" value="Replication factor C subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000136">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF1">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13177">
        <property type="entry name" value="DNA_pol3_delta2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22534">
        <property type="entry name" value="RFC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="33"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO02818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="351" mass="39596" checksum="48F8F4DEF64C4EA9" modified="2014-11-26" version="1">MLWVDRYRPKTLKDVELYPELREVLTRLSKAQDLPHLLFYGPSGSGKKTRAMAMLHEIYGPSVYSVRLEHKSVQVSDSKVVDIATLSSPHHIDINPSDAGYYDRSIVMQMIREIAQTVPLHTTVNSGKSVPYKVVVLNEVDKMSRSAQHALRRTMEKYMSTCRLFLLCNSTSRLIPPLRSRCLGIRVALHSKENLKLAVQRVCEGEGRPLPSEAFLHALAMRSDGNLRRGLLMLEASAMTRVDWSGNGATIPQADWKLFLDEISHDIVAEQTPKRLHEVRLKFYDLLAQCISGETILKTLVDSLLTAVPPTLQRPLIELAAKYDHNMKLGTKSILHLEAFVAGVMKLIKQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3F5</accession>
    <name>A0A088S3F5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_356350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703564.1">
        <property type="nucleotide sequence ID" value="XM_010705262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3F5"/>
    <dbReference type="GeneID" id="22579663"/>
    <dbReference type="KEGG" id="lpan:LPMP_356350"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350072000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_356350"/>
    <dbReference type="eggNOG" id="ENOG502RKXN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275834at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO02764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="185" mass="21205" checksum="F1951E79F4E73247" modified="2014-11-26" version="1">MVLNKWAVVTKSAPPAAGLRPLARTVSPNPKLRPADYKIPYVLRTFIKDRHLSEMQHIENRGMYREELSIERSRFPRMHKTLTIQTDGSLNESEFEFAVPPVVMLFQDRLSAHRQRQVALAKIGKLKRIKSWEAAVRGKESLNPVCNALVFPYCVPKKMLVRPRIVDPLSAKSITDSRRSREDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3F7</accession>
    <name>A0A088S3F7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_345060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702925.1">
        <property type="nucleotide sequence ID" value="XM_010704623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3F7"/>
    <dbReference type="GeneID" id="22579011"/>
    <dbReference type="KEGG" id="lpan:LPMP_345060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340058700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_345060"/>
    <dbReference type="eggNOG" id="ENOG502S7FE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272605at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="241"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="326" mass="36345" checksum="4BF366A23A2454EC" modified="2014-11-26" version="1">MENTSAATSDGLRRTQQYLAEVIDECVFVERQRELTERRLSSQLESQRTLIEDLFSVLRDVCRYMSTMEDAILPTLLSTIPATRSEHRQLVQLRSAIRDTLMRFRQDNGAHREDDMLLPTIQHISSGSREGNVPIVSLDRAAKAGAEVMQRLFEGEARFVDALTRATARVEATHAATATENSELTALRARMDELSCLVRSSNTGLLKTAPGPSAPLGLMTAAAAAQEDTSPAATRFAEARVIAYEKTVQALNNELALLHENYAALSRARACDIETLKRHMTDAQRKHEDQITECDAVLNRISLELEQLIQENAQLRCKLQTIAQPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S478</accession>
    <name>A0A088S478_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_110710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696919.1">
        <property type="nucleotide sequence ID" value="XM_010698617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S478"/>
    <dbReference type="GeneID" id="22572936"/>
    <dbReference type="KEGG" id="lpan:LPMP_110710"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_110010700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_110710"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269113at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="44"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="128"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="161"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN96266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="226" mass="25313" checksum="A61A8FDF10E1CF58" modified="2014-11-26" version="1">MFNANNDSEMTYFTAITNRDVEAMKTLIAQNCNVNEVAQDPALYHRTPLHMCVWDNFVEGAKLLLDAGADVNALDDLHDSPYLLSGAEGRQEIMEHIYKNAERTMRYGSQTSCRMKTSVPDYSIVNRFGGSALIPACERGHVEMVRLLVQKGVDVNHYNHYHWTGLLEAIELGGDDREHVEIVRILIENGADVNQVDGAGKTPLYLARKREQKRITALLEAAGGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S4L2</accession>
    <name>A0A088S4L2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribonuclease H2 non-catalytic subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_120990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009381">
        <property type="protein sequence ID" value="AIN96426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697079.1">
        <property type="nucleotide sequence ID" value="XM_010698777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S4L2"/>
    <dbReference type="GeneID" id="22573105"/>
    <dbReference type="KEGG" id="lpan:LPMP_120990"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200067000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_120990"/>
    <dbReference type="eggNOG" id="ENOG502SCGI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6222486at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013924">
        <property type="entry name" value="RNase_H2_suC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08615">
        <property type="entry name" value="RNase_H2_suC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN96426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="111" mass="11966" checksum="7A0F534373915CF4" modified="2014-11-26" version="1">MARSSNDGLWRATLRGRALLGEEVQLPEGYAIAMTTVTTNKTFSPPSPTSASLSTFITPTAEADEIETLDQVSIQACASRYVVWEHDKAPTAAATISQWVTLAQLIHTSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S665</accession>
    <name>A0A088S665_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_170130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697704.1">
        <property type="nucleotide sequence ID" value="XM_010699402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S665"/>
    <dbReference type="GeneID" id="22573756"/>
    <dbReference type="KEGG" id="lpan:LPMP_170130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170006700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_170130"/>
    <dbReference type="eggNOG" id="ENOG502TKC4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="332250at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010564">
        <property type="term" value="P:regulation of cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039893">
        <property type="entry name" value="CEP120-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21574">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 120 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21574:SF0">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 120 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="362"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="192"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="333"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="288"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="484" mass="53044" checksum="E644CC846C018BA1" modified="2014-11-26" version="1">MGSSSGSGGSNRKSDGDRGGAGAQRRSPLDHALLPDSGVHARITSAHSLPRARETSVTATGRSSSSSQDAPLTRGNPAATSGEKSPPHPTTARFVISDSTPFLSAESSVPAEAAVHDVRDTAEYRAAWDLELWKAVQADRFRKELEKQRSSAFADLKQLVKRREKEALMALQQRTAAVTLREEAVQAEETRLAERQGRVADMEKDMRRMRQQLLDAQQRVEDEVRAQVRLANDTIAHRARLLEERVKAAEAQTRRADERQRQAQQEYLSLYEAFSRYRTQQLTSPTPGSGGITATAGGGTASSSLQVEQLRLQWEAEHQLQLDRQTQRHALDMAVAQQRCRELEDQNRRLTAALVRRREQLRRHVGDASPPSLPTSVSQRQLPQAGREGREVASGSGTAALPSSTSSFAAGAAATALLTPTHNTAAHCDFVEHTGRELQRLETERLSLVVGSSGALRETDAVIVRIDARIRELREQLAVVTSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S6U8</accession>
    <name>A0A088S6U8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein S8-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_180800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697914.1">
        <property type="nucleotide sequence ID" value="XM_010699612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S6U8"/>
    <dbReference type="GeneID" id="22573970"/>
    <dbReference type="KEGG" id="lpan:LPMP_180800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180010900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_180800"/>
    <dbReference type="eggNOG" id="ENOG502QSV9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275953at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S15A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN97261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="239" mass="27673" checksum="42D9571AC2EE0D79" modified="2014-11-26" version="1">MSEQRIRQQLNALLADERDPLAEARRQNAAGSAALSGRPLPQRRLVNLPGVERVRDLPADPITRLFFQHQGDHALYYGTYDQPSQLDEDRVQLEKREPKDWTFNVITPMYDFCHRLREASEQRKRFVIVPSTIETRGCAKVLLDHGLVAGFRDFNNDRAFAVELKYFQNEPTINVVEPCSYDGKTEFEWSPKMMRRLLNTHGIHNRLIIYICRTADNRIIDHIQAVKECIGGRGLMMAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S810</accession>
    <name>A0A088S810_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_202120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698413.1">
        <property type="nucleotide sequence ID" value="XM_010700111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S810"/>
    <dbReference type="GeneID" id="22574421"/>
    <dbReference type="KEGG" id="lpan:LPMP_202120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200026700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_202120"/>
    <dbReference type="eggNOG" id="ENOG502S3CC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="238850at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="188" mass="20911" checksum="979C8350696169F9" modified="2014-11-26" version="1">MSFCIEKQPARNSSFPTPGESYLILASSASLRKHLTDSYWCEAMEQVCAGKLEGIAVRYTGENIVMVQFRPTNLSPAGYRYPLFMSIPIEFLVPVAESAFTIPATADLQGSFGTATTSSFHSRSSSEDRSPTHGSTLPRLCVVCGRFNVPGMTHRAHGWKCKECKGTKSDNRLRKEAQKLRKRMRTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S8S0</accession>
    <name>A0A088S8S0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Calpain-like cysteine peptidase, putative</fullName>
            <ecNumber evidence="5">3.4.22.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_205350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.-" evidence="5"/>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN98026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698733.1">
        <property type="nucleotide sequence ID" value="XM_010700431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S8S0"/>
    <dbReference type="GeneID" id="22574747"/>
    <dbReference type="KEGG" id="lpan:LPMP_205350"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200060500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_205350"/>
    <dbReference type="eggNOG" id="KOG0045">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="424753at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015232">
        <property type="entry name" value="DUF1935"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036310">
        <property type="entry name" value="Smp-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF423">
        <property type="entry name" value="LEUCINE-RICH REPEAT PROTEIN (LRRP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09149">
        <property type="entry name" value="DUF1935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101601">
        <property type="entry name" value="Smp-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="4">
        <location>
            <begin position="351"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="582"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN98026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="849" mass="94559" checksum="7FAE45AF95EC25CD" modified="2014-11-26" version="1">MTSQDQHTENAACVDSGEFAPQEQAEGAPGAAEQSLTFADEENPDPPCEVQRAEECPEQSVPLEDLETQVHEAPAPEEYGEELAEHAPQQSHPPQYCPEDSEAQVVPQQAYEEEAPQAYPEETDDYYAAPQHAYEEVAPRYVHAAAPPSAIVKPRTRNVKSVARWEPVEYDPRDGSDDEFELSTCMAPVYEGEGEGGSEDASVLKHGGPDCKGEIMSCFDEPNLLYRIIDPKKKTWAFYNDSLHYEMHVQFTFGKYSKLQPLENTTMRQNEEGQYVMEVVVYPTETEMFAQGSVNGFTSKLCAVPLTDNYHNARRRITEEQVSNEMAAIQQATGSDNAEEVLQACIENGIPFVDPEFPPCQASLDAGAGKPFKPLAWARPEVCVPEEMASQVRLFRGNVRSGCVDAGDLGDSWVMCSVASVSEDPARLMGMFRHPEGKAAAQREHAVGAYRVTFNKNGWWRSVLVDSYLPVSGGKLKYAKSATDPAEIWPAILEKAYAKLHGSYAKICSGDPLHALQDMTGFSVMRFDDSLADKTSNQLFSDLVRGIAVGYTVICSTPGRGPQDNDQDLSEAYAQAGLVTGHAYTILEAKYIESKDLRMVRMRNAWGRGVVWSGGWSDDDTKWDENPDIAEECNFQKADGTFWMSWKDVQKYFNGGGVCFTHQPGYDYRMNCVFTDGVPSAVLEIEVQSPAWFTFVISQDDRRCQVNASEYKPVMISIAEPVEGDMYKVVMNSSANGARPTSDKWTFLQARDISLIHKLDVGKYIVVPRIMPLDDPIEPVPYVLGMICNKEVGNGDVSVMFKRLDADNRVFENFPKFEPELMEVEQPVQYQKRAPGEGFPMTQMGEELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S8W7</accession>
    <name>A0A088S8W7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aminoacylase, putative</fullName>
            <ecNumber evidence="5">3.5.1.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_205850</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">The Mn(2+) ion enhances activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20 family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.14" evidence="5"/>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN98076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698783.1">
        <property type="nucleotide sequence ID" value="XM_010700481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S8W7"/>
    <dbReference type="GeneID" id="22574797"/>
    <dbReference type="KEGG" id="lpan:LPMP_205850"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200065900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_205850"/>
    <dbReference type="eggNOG" id="ENOG502QQEM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6119954at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004046">
        <property type="term" value="F:aminoacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000001">
        <property type="entry name" value="N-acetyldiaminopimelate deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014:SF63">
        <property type="entry name" value="METALLOPEPTIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G09600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PEPTIDASE M20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="4">
        <location>
            <begin position="244"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR005962-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN98076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="450" mass="48813" checksum="70EB7669B7B76A2C" modified="2014-11-26" version="1">MPPILTPVQPPITSPPPLPLPPSIFEPSQLSKRFYSSLLSSTLSAYSSVIYISIMASLISDLIKAVQPEVVQWRRHIHEHPYVAYEEQPTADYVADLLSCMPAPLDIRRLTPNSVVADLRGGAGEGPMYALRADMDALPLQEESGEPFSSKRPGVMHACGHDAHTAMLLGAVKVLCQMRDRIRGTVRFILQHAEEVSPSGAKQLVGLGVLDGVSMIFGLHVDAMRPSGSIWCRVGTIMGACNDFDIVIRGAGGHASQPELCVDPIHIASEVVANLQSVVSRRVSALKAPVLSVTHIAGGTGAYNVIPDSVHMRGTLRCLDRDTQACVPGLMEEMIAGITKAHGAQYELSWVEPVTVTYNDPKAYEVAVQASRDTLGEENYHVLENPKFGVEDFSEYTTVIPGCYILLGAKPFGDARFSPAHSSTFRIDEDAFLHGIGFHVNVIRILMIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S9N7</accession>
    <name>A0A088S9N7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">N-acetyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_220570</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family. GNAT subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699058.1">
        <property type="nucleotide sequence ID" value="XM_010700756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S9N7"/>
    <dbReference type="GeneID" id="22575103"/>
    <dbReference type="KEGG" id="lpan:LPMP_220570"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220010700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_220570"/>
    <dbReference type="eggNOG" id="KOG4135">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5043642at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039135">
        <property type="entry name" value="NAT9-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13256:SF16">
        <property type="entry name" value="ALPHA_BETA-TUBULIN-N-ACETYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13256">
        <property type="entry name" value="N-ACETYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="282"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="244"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="390"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="250"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN98351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="456" mass="49627" checksum="C6D4FBC693C20084" modified="2014-11-26" version="1">MINEHVCLISDGVLLVPYLAPFVPRYHEWMCDSGLLAATESEPLSFDEERENQVSWLQSTDKMTFILLAPVKVHRDDASATECRRLSNDAEEQQQMTDGTGARLVRLRGSVPPLAEVFGSTSLSPVSSLAPFCRSGGGVLYPGSIVTAADHACVVGEFHPQQNLPSSSGEAIPLLKRYAPSQMKELFNNEAISSASQQEGTCTRAEEALRRALVHPYVMIGDCNLFLLEEDDDGTDEVASGISALDRSSPCGQPQSCRSPQSLAKSSSDNTPPTPVSSMAPSRTFEVEVMVADTAFRRRGLAEAAVRMIMQYAVAVCGATRFVAKILDKNVGSIALFTKRLQFVPFKEVKVFHEVHFARSLITEMERRAWELECRRSSCRHGASNTTSLHARTAEHGSCSGAVPGGSRGAEKLEEEPPSASPPHLPQTESEIGHTYWCAPLDDALASSIRVFTQTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SAP3</accession>
    <name>A0A088SAP3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase, putative</fullName>
            <ecNumber evidence="4">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_240620</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="4"/>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98696.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699403.1">
        <property type="nucleotide sequence ID" value="XM_010701101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SAP3"/>
    <dbReference type="GeneID" id="22575471"/>
    <dbReference type="KEGG" id="lpan:LPMP_240620"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240012100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_240620"/>
    <dbReference type="eggNOG" id="KOG0324">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="412286at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101005">
        <property type="term" value="F:deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF56">
        <property type="entry name" value="PPPDE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN98696.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1020" mass="109134" checksum="F8DBA41E75C8CD1B" modified="2026-01-28" version="2">MGLSRGHSPRLRCTEVQIPVILNVYSLVESNKRLSKMGMGIFHTGVVVYGIEWGFGEVVDNPNASGLFCVPPGQAAGTLYRTIRIGHTTRSPMQVDTILHRLENEWRSSEYHILHHNCNHFAQAFCDLLSTTEKLQVPLWCNRAARVGDRVIPRRLATKVQHIMDSETPKAPPPPAPTSKVNEVPTSVVPHEWYLNPSIFQPPRYIDESKPPSVGIEDVHSGTPPEATVGEGGPHHSVEYSVVPQPSCELADAGGVRPPTTWHESCCNTDENGSITHMVTIEEQPSLPSSSRRESARKSTASRRMAKSTPKRSPPPSLSIAFSSGGEDRVVLPCVRASTSQPYSVVPTGSPQVSELGQDVENLLHSETSEEPSPLIVSHLPMIQSPICDTANPRKVTPSGSMTNRSRGVCLEEQQSQQQHIESYSKNEHTNASSKKPLSTMRDSSMQFTSAALSDHEDASAQPPSSSLLASHALAVGCITSLSPTLPSQPPEEVTWRSSDVMAAKHDVSIELTNVSSEVSNNPKGNLAPAKHSSPKEERNRGNKPENEFSDITTALVCDASLPFTTATRSPEAVKRKNSSVWKFLKSQCGLSSHAGSEKAARKYLSTLPPSDKVSFLSDGGPHVDVVPTSPASSVPSSSSSLLQREATQKEAASVVADSGAVADPAADAAMVQGWERDHTHVLPSAAAILPSSPQSMSLILEDKDNGHDAIPNEVQDANDTVPTPTTPAQQNVLVMPGLGGGSPASTTVLQQSSGHESTQLPLNRHPSGAESITEMLREPPERHLSRSETPSAQGGAPSPVRLQDLSLAATASQPMDSSGLQLSPSVVTPERPDIIANSEAMTTGCSPAVAHQQGRRGSSSAAMSDTPPPRREQSQMPIPVTQKQSCSDENVAPAIQLYLSSDELETPVGCNSSYLSGTAERAGTPLTAKTAHTPMEPFSCRPPSLYREKAVTDDGRISQSTSDDGSQAALTEQHSRNTELEDLVNFRLTQSESAPKLDAKRSPTPPPPSLPPPSPCDTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SCM8</accession>
    <name>A0A088SCM8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_270840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700173.1">
        <property type="nucleotide sequence ID" value="XM_010701871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SCM8"/>
    <dbReference type="GeneID" id="22576260"/>
    <dbReference type="KEGG" id="lpan:LPMP_270840"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270015400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_270840"/>
    <dbReference type="eggNOG" id="ENOG502S33B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="240847at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="504"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="538" mass="59190" checksum="5571239956352F67" modified="2014-11-26" version="1">MDLEVVNVGDGRRATLVEHLLARLEQHGLRRRLAAEDDATSYAVDVAARGDTGESAEDGNDEVNTSGENGTDGSRAAPSCSSSVGDFSPVAQSKASQTREAYYYLCVPCELRLTRISRRPPPWRALEDVHFHFSSATHRATASWMADDDIDETLHSTPLVTPTDYYSRIYVNGIPTLLSRRPGGGDMFYPLPHEQELVASLNASAACDYDGVDERHGSRTKSQSSTVSVTHTGGLFPPSAPRGAQGGAPVLWHRALLSLYTKMVQVVRRTRSSSLADVSSDRRKYRVDRTRSRIMVGVDHVSLGEYREQSWLPLYKVPLSLAVYRLRRERVPKPLLARPEYTGRQGQAVPLQCSEAAVLAAQAADVAHRSVYTQPYQPISEGSRDDHRQSDAFSTSIPVPTTVFEDECYRVALLSAVERAHHEDLLHTETSRRLSRSVCVANGEPQEMHHPVLTLELLMQHTQSTSQPWGPAVGSNTALRSTFVSTTAPPMLSHRSSIGHLTRRSSPSSTSSAPVSEDPTTSSSSIHTRKRAKREGCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SCY6</accession>
    <name>A0A088SCY6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sm protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_271970</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the snRNP SmB/SmN family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700283.1">
        <property type="nucleotide sequence ID" value="XM_010701981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SCY6"/>
    <dbReference type="GeneID" id="22576375"/>
    <dbReference type="KEGG" id="lpan:LPMP_271970"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270028000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_271970"/>
    <dbReference type="eggNOG" id="KOG3168">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2020720at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070990">
        <property type="term" value="F:snRNP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01717">
        <property type="entry name" value="Sm_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000049">
        <property type="entry name" value="Small nuclear ribonucleoprotein-associated protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIN99576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="110" mass="11881" checksum="AC947FFC8E3B5514" modified="2014-11-26" version="1">MGKYTMLHNINRVLCVVLDDGRSVTGKLLVFDKHMNVVLGDAVEERPQSKRMAEEGVSSKRQLGLILLRGEHVVSVTVMKDVENGGSGAAANFSGAPKSAKATAMKRKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SCZ5</accession>
    <name>A0A088SCZ5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_272070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700293.1">
        <property type="nucleotide sequence ID" value="XM_010701991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SCZ5"/>
    <dbReference type="GeneID" id="22576385"/>
    <dbReference type="KEGG" id="lpan:LPMP_272070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270029000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_272070"/>
    <dbReference type="eggNOG" id="ENOG502S37V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273814at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="397"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="437"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="632" mass="69402" checksum="A02B6AC4F5A61009" modified="2014-11-26" version="1">MPDIPAVVVLRHRMGSSMVVLKPHQRKSYSRHDLESFILYKEQKYNAVNVLWRFSILLLLVFSFSVFCLVLSTFTTEWLGVQSNNSFLSVGLFFSCRNPPLHTCTSWQSSRLEWTVVDPVTEATLCHASAGFVRRFSGALWTMGTLQLLCEVAALVLSLWITARPTRSGALVLLIFDFLLSVCSGIVTLILFTSYTSCLRRTCDGERVPGGACDVRYRYGYRLHIGSVAVHGLLLVLALCMHSYIHNIRVTSRDHLLTERRRLSHRAQAGESIVRMLDSPTTAGVAGDNGGDSCARSTPDAIRTTLPLDEHQPVGQPSTAAAGPSGAIVTVSDRAVAAPSNNRGRADQGGCEGGGASGNAAHHNSDHGRNNATATTLTKPARDSPSVQDSELHVFFADAPGGADNDGGSALLRDGRSRRHLQHQSVSTLPFGDGRARAPAAETTAASNASGHSTDSSFVTRERSVGTAAADDSGNDQRQCRDRQRTSPENSLLLHTGHQYSAGPQMATAQPSLTSKRQKQSLPHKLRATPVYRQGRKHQNMFLRFFSRKHDSNYLTAAELGVPIAGATDWVYDDRSDMFYSFDQNMFWDPLTQEYYNCALRSWQESPDQIVGVHDILDRMLERPPNSRRSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SDA9</accession>
    <name>A0A088SDA9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_280770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700418.1">
        <property type="nucleotide sequence ID" value="XM_010702116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SDA9"/>
    <dbReference type="GeneID" id="22576522"/>
    <dbReference type="KEGG" id="lpan:LPMP_280770"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280013200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_280770"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="71" mass="8342" checksum="1006CF2D04ECC38C" modified="2014-11-26" version="1">MKMISYSVHREEDAFLAKKESNRVLEKELLHEQELRRETQRRLEAQDEMLQMLQGIREAQSKLGASLGLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SDQ6</accession>
    <name>A0A088SDQ6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_282580</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700598.1">
        <property type="nucleotide sequence ID" value="XM_010702296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SDQ6"/>
    <dbReference type="GeneID" id="22576703"/>
    <dbReference type="KEGG" id="lpan:LPMP_282580"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280032300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_282580"/>
    <dbReference type="eggNOG" id="ENOG502SKV3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250549at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03356">
        <property type="entry name" value="LbH_G1P_AT_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051960">
        <property type="entry name" value="eIF2B_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="11">
        <location>
            <begin position="14"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="12">
        <location>
            <begin position="606"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="539"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="539"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIN99891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="676" mass="71795" checksum="B76F32B3055F7512" modified="2014-11-26" version="1">MSSDTAASCLLDIVVFAGGDSLDLMPLTAVEQKTMLRICNRPLIWYSITPWIEAGFRSFFLCVNEDYATLRAYLSRAFDGVDFHYILVPSNVGDHPSTTCDAVKAYLKYKEALRLGEEDTLAQTSGGALNCEDTVINVEGSGCHFPQVASLHETQLYRGASESRNHGGCANPINRDPLKLERMNSAGLPRDALLLSCDTILVDVDVASFVERHYASLASVTAMLYRPLCKRGGGGSGGDHKVRHRHGKDGGIASVNAAEASYTHGLSCVAYEEADALASMALGATSNTPTFSCSRRLPSGALSQLQRASASLSTHSPCEARTMAADLGHVHHHRMHYLNPLEGKPEVRITMAFAARRPDMTFAADVVDAHAYLMNRWVLEFIAESAGVADMTVRKDILPLLARSQHTTVNTSERAFATPAEKLKVNVPHHWLSEGAGISAQSLNAACGLALPEVADSLRVFCSIYEEDPDKACRVYRMNTRDNYRALNDDIISAKCSQLHLEEPLLNAGGAAGSGGAGGGGTGVVNRFTLPSLLPHGGAHPGHYGGTGGAAHGDSSKPAPSAGAMALATLLPDNPITLRERVDDQQVYIVGSFIDSVPPPNVFVTRSVIGAHVTLEPGARITDSILMGNVEVGAKAVVLNSVIGTGAVVNAGCRVVGTTVGPRCVVEENASDTIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SDR0</accession>
    <name>A0A088SDR0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_282640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700603.1">
        <property type="nucleotide sequence ID" value="XM_010702301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SDR0"/>
    <dbReference type="GeneID" id="22576709"/>
    <dbReference type="KEGG" id="lpan:LPMP_282640"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280032900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_282640"/>
    <dbReference type="eggNOG" id="ENOG502S9WE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="252656at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="299" mass="31704" checksum="8969528CC922392D" modified="2014-11-26" version="1">MAASGGDVAQPLPKSAVEATGAGESATVSAAGAAESSPHDSFPSELHVGHPQGGQHGSGSSIGDDSDSVEVEVEEEIDVCPVYEDDGMTVRALRTRGGYELTLDERDLLEDVAGGDEKDAAADGAASSPCSAPPSAAATVEEDEEADDDNHDEHDYGVPFVAKVDQTANSAAAAESEDVAADTDLPVEAEAEEWSHLDFDDEDEDEEEAALDEVVLVAVVEQLLQCCEADDLDPQMSAEAARFISAAKPLLEQLTKEVISPAEFVQRMDRDLRRFQRIYKSVYRPRDSPVVIEGVVTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SFF2</accession>
    <name>A0A088SFF2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-hydroxy-3-methylglutaryl coenzyme A reductase</fullName>
            <shortName evidence="4">HMG-CoA reductase</shortName>
            <ecNumber evidence="4">1.1.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">HMGR</name>
        <name evidence="5" type="ORF">LPMP_303150</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(R)-mevalonate + 2 NADP(+) + CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15989"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.34" evidence="4"/>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701337.1">
        <property type="nucleotide sequence ID" value="XM_010703035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SFF2"/>
    <dbReference type="GeneID" id="22577368"/>
    <dbReference type="KEGG" id="lpan:LPMP_303150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300036400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_303150"/>
    <dbReference type="eggNOG" id="KOG2480">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="310654at2759"/>
    <dbReference type="UniPathway" id="UPA00058">
        <property type="reaction ID" value="UER00103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00643">
        <property type="entry name" value="HMG-CoA_reductase_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3270.10:FF:000003">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.420:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl-coenzyme A Reductase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3270.10">
        <property type="entry name" value="HMGR, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.420">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004554">
        <property type="entry name" value="HMG_CoA_Rdtase_eu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023282">
        <property type="entry name" value="HMG_CoA_Rdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00533">
        <property type="entry name" value="HMG_CoA_R_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572:SF24">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="NAD-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="Substrate-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00066">
        <property type="entry name" value="HMG_COA_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00318">
        <property type="entry name" value="HMG_COA_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO00537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="434" mass="45843" checksum="524C3EA015B770A1" modified="2014-11-26" version="1">MRRSILLACSAAKGGNWASMSDAEIMKQVEDKKIAFYGLEQALAPDYDRAIAIRRDIVKKKMCPSSAATHPLERMPYKNYDWGNVVGQSCENILGYVPVPVGLAGPLLLDGKEVGLPMATTEGALVASTHRGARAINLSGGCRTAVLKEGMTRAPVVEVSSFDEAIALVKFCEERFDMLKEAFESTTRFGKLQSIKCAMAGRQVHMRFSAFTGDAMGMNMITKGCDKALRVLQQHIPSMRVLALSGNFCTDKKPSAVNWVEGRGKSVVAEAVIKRCVVEGVLKCTVDSVVSLNVTKNLRGSALAGSIGGFNAHAANIVAALYIATGQDPAQVVESATCMTTIDKVGEDLMISLTMPSIEVGAVGGGTGLSSQSAMLELMGCAGANKEDPGANSRQIARVVAGAVICGELSLMAGLAAGHLLSAHMKLNRKPSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SFY1</accession>
    <name>A0A088SFY1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Heme-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_311090</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701497.1">
        <property type="nucleotide sequence ID" value="XM_010703195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SFY1"/>
    <dbReference type="GeneID" id="22577535"/>
    <dbReference type="KEGG" id="lpan:LPMP_311090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310017700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_311090"/>
    <dbReference type="eggNOG" id="ENOG502SPGM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF25">
        <property type="entry name" value="CYTOCHROME B5 HEME-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="5">
        <location>
            <begin position="9"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO00697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="112" mass="12501" checksum="38A3FF8879436394" modified="2014-11-26" version="1">MSVASSLHFIFKGKNYSVPENFVTKEHPGGKAILMALVNKDITEGFEEAGHSKDAMEMLEEWCADVSTTERVELQKRAEARLAEEDEWRWRSTAIAFSVAAVVAAVVLRRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SG59</accession>
    <name>A0A088SG59_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aminopeptidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_312090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701597.1">
        <property type="nucleotide sequence ID" value="XM_010703295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SG59"/>
    <dbReference type="GeneID" id="22577635"/>
    <dbReference type="KEGG" id="lpan:LPMP_312090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310027800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_312090"/>
    <dbReference type="eggNOG" id="ENOG502RXA8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="263805at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF299">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="3">
        <location>
            <begin position="202"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="2">
        <location>
            <begin position="382"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO00797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="617" mass="66347" checksum="1128B13287CDD7FD" modified="2014-11-26" version="1">MAPGPYIWSPIRCTLQLVFSRPNSGEAILAGSAYHGTSIIRYRREPYCDAAKSNVSTTTSSKTSSGDNSEYDNFLRHRRVIAEKSALHFHALTTAGGIYKDAKVLNVQSYQVRCVSPSAGAATGVLKVVSVEHEDGGAVAAGSSTTTGSAAKMKGNAKGSKKRGLAGVENDVRTSADAPSPATVDWGSKLVLFEGASSLPPFCEVDLTIRFVGAVQSFDHGGIYAARGSDSNPSTEDVPLLTHFEVRFARCAFPSPDDPQYRLDWQLKSIQLPSCFHTILTNGEERGRKQLLAQQAMQVSFAPCGPLPAYVFSFACFPDAASLESTSATGDGLDVLEGRLVIPKFLGDITSSFSNAPIPVRVLARRQARIATATLERVLRLTIDAVTALQQLFQCPLPLLQCEHLDVLLGPTMPYISGMEHHCSIILNESIYQADKKAAIGSRGGGGANSNAEVGQTELIVHEVTHHWIGNALGLPFAVKEGICQVIEQCVADTLLGKPMRKYKADSGGSAKFNSPSPSSSTAKVPKSTIQASEKGHEFTGASYQHARSAIKQLIADHGFDRFLLCLQQLLHKHVVIPAREVEEKGEIEVLRRIGADVTVSPYLSTREFLHAVETSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SGR6</accession>
    <name>A0A088SGR6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinetoplast polyadenylation/uridylation factor 2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_321210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701807.1">
        <property type="nucleotide sequence ID" value="XM_010703505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SGR6"/>
    <dbReference type="GeneID" id="22577862"/>
    <dbReference type="KEGG" id="lpan:LPMP_321210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320017400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_321210"/>
    <dbReference type="eggNOG" id="ENOG502QWR3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277625at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="CDD" id="cd23675">
        <property type="entry name" value="KPAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="756" mass="82783" checksum="AE15D07587170183" modified="2014-11-26" version="1">MPLLKSFNRCLPGFSVRSSAYTNIYRWCSSPSQSPIPEQPQQTQAHPSPITNSGLGVSHPAASLDLGLNFAKMDFEAVARATQSAIARERSASHLSQQRLEKLEARLKKQVNTSAAPQHAKPAPAPPLALSSDGIPCEPAPASHSASSPQSRRDNHSPVPGQQLPPSPTQRSHHFFGRDGSATRYSLLDMLKDCVADGQGVRALQLFTNAVDQACRQVLVPDGSAKSAAAVTASDSGSVASSTTPELECFGAMRKMLASLPPRQPRDRAAHLTRAANVKNMRGIMRWTGQHYYLLWKCLLEAGHVEELLRVWSVMQHIGFVEYQLEERTANALMALLRRTAQPTEVMIATVVSPDISVAEATSHQKDIRRELMKGLAQAAAARKFKLTDVNRRVAEGIRIAEALRRTEQGCDGRHTSADPGAAHDDDDGANATLVTDTDEAAVVVGDFNGLLRRARTFEGTNRVLHMMAKLNIEKEAITYASLIAALHNPQYVLPGHTAEELAGHQTGGATSPQPTGIEESGGTVKDVSTSGYPSTSVDPSRTKTSYEAYKEERIKAGMAWFAACPETQRTADVFNELLYLLRAKSHWLQFDTALTQLRGNAVVTETEWPEILRSAETHTPRSVSAITEVSSVSGPILPPRWSTWPNGKTYELLIHRARYVHQWEVMWALYEEMIASDVRGTPRVYEVLLVEARSHPPQSVLAAEGSGDTDASSRFLLRLYEELRRNGGDVHSLKGTLNVVNAWSKARTKSNRWGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SHT8</accession>
    <name>A0A088SHT8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_331100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702202.1">
        <property type="nucleotide sequence ID" value="XM_010703900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SHT8"/>
    <dbReference type="GeneID" id="22578263"/>
    <dbReference type="KEGG" id="lpan:LPMP_331100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330016100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_331100"/>
    <dbReference type="eggNOG" id="ENOG502RYEZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="257265at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000740">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="428" mass="47903" checksum="67EF5B4A7E3A2070" modified="2014-11-26" version="1">MIPRNVPYEHNPPRRDNIVTVVMPGITSCRSQLSRYTGGDPLQVLCNWSDVDPTDPLHIADAGGNRFTGMSLAKRLRLALQQWRSVVMGWKSDRSESDEDDDVVDAPQRTSPDVVRGGASVSLSVASRTSPSSFGTAVQAADLGLIDPPVLYSATCRIAPRLLHGVLASPEVAEVRHCGWYRTINPMHWVLTVKELITCWSFSVRPFQWCFSEPGRTNTAGIRDQAAFTREVRRAVRHIKAAPTAEPHNNRTDVEARESTPTTINKKHLVLFGVSRGATTCFYSAMKLAPEEAKHVSLVLVEAPFDTLDHVIDTSCWAPCLMRWFVRSFSDWRGSQEERLAYDFDPQKVHLRCPVAFVMSVKDTRVPINCTQALIDRVQRELVPHVIPAVEVLVLQHSRHATMAVGSKEDQDAYVAFVERLYNTYCSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SIA2</accession>
    <name>A0A088SIA2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Radial spoke head protein 9 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_332610</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell projection</location>
            <location evidence="8">Kinocilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the flagellar radial spoke RSP9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702352.1">
        <property type="nucleotide sequence ID" value="XM_010704050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SIA2"/>
    <dbReference type="GeneID" id="22578414"/>
    <dbReference type="KEGG" id="lpan:LPMP_332610"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330034000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_332610"/>
    <dbReference type="eggNOG" id="ENOG502QR99">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10258956at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001534">
        <property type="term" value="C:radial spoke"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035082">
        <property type="term" value="P:axoneme assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060294">
        <property type="term" value="P:cilium movement involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044458">
        <property type="term" value="P:motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006802">
        <property type="entry name" value="Radial_spoke"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055316">
        <property type="entry name" value="RSP9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22069">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22069:SF0">
        <property type="entry name" value="RADIAL SPOKE HEAD PROTEIN 9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04712">
        <property type="entry name" value="Radial_spoke"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIO01552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="319" mass="35580" checksum="94B4D778EC7BED5C" modified="2014-11-26" version="1">MTSAHLFQYAFMAGASFSPNERAQLSSSLPLLSVQTKRKDLVLWGKIFGCKADYIIVEAFDDDAVVEPELYYTLDEGHTFSLLGTFSSVFAMCPSYSTSSGLQQEEWKQFMLLGMRGPFIGDPAYEYRVSNPSASHDAPEIQSVKESVRLALFIEEYDHECRVVPRGAYIKAERQLTAAIAPPAGVDIDAGERAEVRRNAAFSGLPRTAEGALSLCNYYHLRAVNPYRRLLARSRNSLFTKSALEQLSEHPLLDGPFESLAEDVPSGTWQLRYDAFHNVVMGRSIRFTGSLFYHVPETSVYGTVYMGDGNMNINAAFEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SIN0</accession>
    <name>A0A088SIN0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTP-ase activating protein, putative</fullName>
            <ecNumber evidence="3">3.6.5.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_340240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.5.1" evidence="3"/>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702452.1">
        <property type="nucleotide sequence ID" value="XM_010704150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SIN0"/>
    <dbReference type="GeneID" id="22578528"/>
    <dbReference type="KEGG" id="lpan:LPMP_340240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340007600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_340240"/>
    <dbReference type="eggNOG" id="KOG0705">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044518">
        <property type="entry name" value="ARF_GAP_AGD11/12/13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46220">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN AGD12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46220:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN AGD12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="2">
        <location>
            <begin position="312"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="625" mass="69801" checksum="7952B434938B4E78" modified="2014-11-26" version="1">MDEVSLDTLVLSGECDVQWGSRGTLTVRRTVELHANNILYCFEEPKNSMAKHIKEKVYVEGCRVVDGGAYNDTTERLLLFLANHDYAERVDLFGNHQVYIFAPEKTTHDAPLGEAIQSASMSPPQSANYVVQLFLSDKIVKWHLLQVIQRASKEYSQLIPDTNTKLALSMTRTVGSGSVHTGQSTVARPPGSGVPNRFESKVLGQASLNPHHSRTESDVSVLSDHEVLQLTDVLREYEALQERKNKVGGMASLLQQPKGGEEDVRKAPSDDEGLETAGCMAGNEAGQAVPLSELRLNAPACLQQSPLYDSCIASKPANQICAECGEPFPSWCILQPFGAFVCIQCIGVHRKLWSNKCRSAELDRWPNSDIEFMKARGNDVVNNELEYYVAFPTDSVEFALHPEPVVKPMRSFSSAEVRESFIRWKYEELLFTRRRHPTAKRPLPPCSDPVGQERSRLATTTSSVQAAGYVSDVSYGAATQQQHQPFFRDQGPPRYAGLLDIVVKELVGPEWISGAVCVLTNGFQTLRTQESRQLLHMRHSTAWDEHLQLGIEGTGQKPLYCTIYRRRGELLAATEVWMKEDVFQPGANCMFASKLVWSQLHKKPSQRTPGESWKITFLTSYQLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SJT3</accession>
    <name>A0A088SJT3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_344510</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702872.1">
        <property type="nucleotide sequence ID" value="XM_010704570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SJT3"/>
    <dbReference type="GeneID" id="22578956"/>
    <dbReference type="KEGG" id="lpan:LPMP_344510"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340053100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_344510"/>
    <dbReference type="eggNOG" id="KOG1716">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="426001at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033550">
        <property type="term" value="F:MAP kinase tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017017">
        <property type="term" value="F:MAP kinase tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008330">
        <property type="term" value="F:protein tyrosine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF519">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE MPK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="209"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="279"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="58"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO02072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="365" mass="40293" checksum="6160C315FD183A66" modified="2014-11-26" version="1">MNTQCCTPPSMGGGDDLFLASCQYQLFANEEEDQEVENTALQTSVTIRPSDSFPRLVQSYSSEEIPPSGLLDTNVELPSPPRLPRSPRRAFQPISINLPGDSCFGRTTFQGCSVEATASDNITNTLWPPPTTSTQPTSASTVAPAANVGATHLQTPEVQRTNHTVTTPNIIGQLLYTPQIPPVCQAWRTNLDAELDTVSRRWAPDQMPSITMLIDNALYVGGFPDSQTVSQLHALGIRHIVNCCAQDIRTVPEVASSFHLHNLESFDTEEYLILHRNYDVFAGLISTILEKGERVFVHCVAGVNRSVVLCAAYLMERLSLNPVEAIRVFRTNGRTRILDNKGFRHQLVDHYLQSVEPHSARLGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4K8</accession>
    <name>A0AC62A4K8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_312370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="XUY36699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="985" mass="104657" checksum="90C84545914A21B5" modified="2026-01-28" version="1">MPAARSWMSLLWSGLRPCTRLCHPRDGQRAHGARVHLTRPRLPTGRVPGPPPWDAPGGSLRGGVGGRWGGDTLPRPPGVCCFDACLRQGAGPLKIEGRWSRRHVQATLCVCVCVCVCVCAIALAAIFNVFSNSSRCAPSRTPLQTPRRSPTHQTPPEKNWPLYPPHTHTCAHQFPSQLKGNMTPFSARTLSVFASIFLVTFILSVAVTPGAASVVRYTVIPVTQSDLSELPSTHWAQYQTLCGAPGAARKIPLVDSLNRVFENVATANARFPFYAWGNSSWYVSSMGFLSPTPYGMCNGYCAARFFADLGGTYAFSSDTSVLYGGGGDWPMIGLYAMPFETTAASASESFILTLDSSADGAAYTAVEYCSVPALNQAATAEARLTAQVVVYANGTIIMRYASLPDTRALPAYMPSTGLIYSKTLRTVVPTPTAANGIAAYRFDPVLDACAGHGDAPACTADTGRGCVWCFSTSACCASTLVSEVCPRGQWTAPASSTAAFTPQQFYDVTVDFDTPFVAMADRSHTFALASGYFPLALANPQQNIPLFRTPSLERVYCIPGASCPMQTNTHPCGLLGNTCVNGNYTFSILALESEFIFAKAGRWDARALPQRSRGEELCEEAAGCAEGVVGRLTGAAFSNHYSSMPLFSVQLYADISGVVDVTIQCASCAPGDPMLAHPPMRVGLVRHGVDDASSVMIPQGLLRSGLHVRFVPKSSCVDCGVNGWCDESSGTCHCQPGYYGKSCAACPACWAGSECDDGSTGSGTCLCKGEACEAACAGTSGGSMASRSCAGCDAVGGRCNCGVCECQGGWGGADCNVAPADACRAYSFDGCEVCGQHEGCVFCHDSTCFNPALSGTPGGYTCSYSTPAADTQACATYRSRGLRAHVNINFDFIAVVGVAFAVVVPFLLLSLLVFIRRSGRAVNPMEAFAVTGSPELRSLRREREVVQVAFTRGRALERELMGIPLRQVSLQRLFKRRKVNLMSEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4L9</accession>
    <name>A0AC62A4L9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase M20/M25/M40, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3320390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="XUY36747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="472" mass="51182" checksum="D9528480A5A26E51" modified="2026-01-28" version="1">MGDCDWTVIQKAVGAEWDASIIPALSAYIEVPNQSPDFDPHWATNGLMEKAFHILIDWVKGQNLLGLSYEFMEVEGRTPFLLVEIAGTERTNNTVLMYGHMDKQPPLRPWAEGLDPHKAVMRDGKLYGRGAADDGYAIFSAITSVSVLQRHGIPHGRVVVVIEACEESGSFDLDYYMAQCKERIGNVDLMVCLDSGSLNYDQLWLTTSLRGVTGGVLNVQTLTEAMHSGVAGGVVPDTFRIARELLDRVEDSKTGTVLLPEAHCEIPDHVAKSMVSMKSVPFKQQFAMADGVSAEPGDNVELALRNFWKPSLTVTGANLPEPQIAGNVIRTLTSLKLSLRLPPLVDSGKATQAMAKLLTTNPPYGAKVWFEPEVPGDGCATPELKPWLSNALNEGSKMAYGNPLAYQGMGGAIPFISTLTKMYPQAQFIVTGVLGPKSNAHGPNEFLHVGYAKGLTLAISHVVAAHFLLAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4M4</accession>
    <name>A0AC62A4M4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Beta tubulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3320200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="XUY36728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="378" mass="42580" checksum="E436946AC20ECA6B" modified="2026-01-28" version="1">MDLEPGTMDSVRAGPYGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELIDSVLDVCRKEAESCDCLQGFQLSHSLGGGTGSGMGTLLISKLREEYPDRIMMTFSVIPSPRVSDTVVEPYNTTLSVHQLVENSDESMCIDNEALYDICFRTLKLTTPTFGDLNHLVAAVMSGVTCCLRFPGQLNSDLRKLAVNLVPFPRLHFFMMGFAPLTSRGSQQYRGLSVAELTQQMFDAKNMMQAADPRHGRYLTASALFRGRMSTKEVDEQMLNVQNKNSSYFIEWIPNNIKSSICDIPPKGLKMSVTFIGNNTCIQEMFRRVGEQFTGMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATVEEEGEYDEEEEAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4P9</accession>
    <name>A0AC62A4P9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NADH-dependent fumarate reductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3420170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="XUY36779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="543" mass="57545" checksum="4BC5586EA8412D02" modified="2026-01-28" version="1">MVSGTHAARLVLKKGHAKPAAPGRGRPRFPGRWRGMMATARGAQRLASDEAGVPHAKPRVLRHAGRFLLRGAPGECAARSRKNGSAWGTAVQKAAGVHDSGELFEKDTFASGKGGSCQPELVRTLSDHSAEAIEWLSSFGIPLTALTQLGGASRKRCHRAPDNPDGTPLPIGFTIVRALENYIRTNLSDIVRIETNARLISLMHSKEDDAVVVQGITYATQTASGEGKIRKLQARAVILATGGFSNDHTANSLLQQYAPQLSSFPTTNGVWATGDGVKAARELGVKLVDMDKVQLHPTGLLDPKDPSNRTKYLGPEALRGSGGVLLNKNGERFVNELDLRSVVSQAIIEQNNVYPGSGGSKFAYCVLNEAAAKLFGKNFLGFYWHRLGLFEKVEDVAGLAKLIGCPEENVTATLKEYKELSSKKLHACPLTNKNVFPCTLGTEGPYYVAFVTPSIHYTMGGCLISPSAEMQTIDDTGVTPVRRPILGLFGAGEVTGGVHGGNRLGGNSLLECVVFGRIAGARAAAILQEGGAGLPLQGGGQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4T8</accession>
    <name>A0AC62A4T8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">p-glycoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2320010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="XUY36887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1580" mass="174440" checksum="E1D93D3FF9DBA9B6" modified="2026-01-28" version="1">MLHEAVNEELPMEMAPAQLSTPSPPWRHNHQSDPLHDYRTAHLKLQERLAEMWGPEAPYTPVPEETSSWFQRYYYGWVYETVLLASKEQLVREVLPPPTQDARAHECGLRLSRAVQAAMYDRNAWNCMVGAEVASTLDPASRGILRWVGLPQQGGYTRMMAGVEWSVPPTARTAERSNDSGASPFFNGIVHGEHLFTPGHSDMSTLEEVACVALLSVDGTSLNPTLVPMPCRLSLSRVLLATLPKDYWWQIVLKLLADVCTLLLPFLLRTFVHFLNERNKSWAYGCGLVAAFLLTQLVQSTCLHRFFYLSIKCGLQQRSALNGLIFEKVFTISSKSLTLPEMNPGRIINMMSTDTEMVNQFMQYCIYLWSSPMVFLISVVLLSYLVGWCSLMAVAALLMTLPINGLILKWEMAGREKLAKATDARVKAANEFFSGIRIAKFMAWEPCFIANIEAKRSMEVAYLKQVQIARICASFVSMATPKLMIAAVFIVYYLLGHELTTTVVFPTIALLGILRMPFNMLPLVLTLIVQYLVALTRISRFLECDNAVCSTVQDMEEYIREQRGHSTACQLAAVLENADVTAFVPVKLPLAPKVKMSLFSRALRMLCCEQCRPTKKRPSPSAVVEDMSYSSPSSTLRHIIVGGTSAMGGAKSASTRSTKTPLMRTNDFFELEPKVLLRDVSVSIPRGKLTVVLGATGSGKSTLLQALLSQFEISKGRVWAERSIAYVPQQAWIMNATVRGNILFFDEEDTARLADAVRVSQLEADVALLGGGLETEIGEKGVNLSGGQKARVSLARAVYANRDVYLLDDPLSALDAHVGERVMEECFLGALAGKTRVLATHQVHVVARADCVVALAGGRVEFSGSSEDFMQTPMFAAMTAEHKLSQRSKGSQDGGDGSEAEEMEVELLKGVGSVTVGKPPMTSGFGDPVTSETNASRVEGAALASSAAKLMTLEEKATGTVPWSMYGEYVGFCGGRMWMVAILIIYTVTEFFAVSAVLWLSLWTARRFSISSTSYLLVYIGCVLLETLTVPLRLYFSYEAMRRGCVSMHCIFLRVVSRGTMEFFDTTPLGRILNRCSRDVDVADNSLPMSMLQMMNCLYGILSAILVTFLTQPLVLIALVPCGYLYYRIMGFYNSANREIRRTSSVVKSPLFSLLEDVLTGSATITAYHRASTVMLEALHRLDLMFSCSFLENLANRWLGVRVEFLGNIVVTMIVLIGVSRTVLAETQDEWVAFVSLSLTMATQTTTMLNWLVRQVATVEADMNSVERMLYYIHEVPQEDMPELDVEVDTLKKRTGMAADVTGTVVIEPASPTSTAPHPVQAGSLVFEDVRMRYREGLPLVLRGVSFQIAPREKVGVVGRTGSGKSTLLLTFMRMVEVCGGAIRVNGRDIGAYGLRELRRQFSMIPQDPVLFDGSVRLNVDPFLEASPAEVWAALELVGLRERVASESEGIDSRVLEGGSNYSVGQRQLMCMARALLKRGSGFILMDEATASIDPALDRQIQATVMSAFSAYTVITIAHRLHTVAQYDKIIVMDHGVVAEMGSPRELAERPDSIFSGMVEALGRIESARVLQMITSTKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A575</accession>
    <name>A0AC62A575_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3520060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="XUY36838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="190" mass="22138" checksum="2AC4B5B2263B3E24" modified="2026-01-28" version="1">MADTYESLATEKRLTPEELDRQVERLTAPRRAVELRDPFEVCPTKRISAEALSKMTDRLYTQSLQHKQELLAAAEQVAYGVHTRGTALSGSPLTPEDQEQSVKRMFHDTLERKRRNMEQLRRQYRYHSPADKTKVPLKTFVQHMYYDRLEAEKKTEKYLYDTYLAPTAIHTGTISRVQADETSNRLCTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5C1</accession>
    <name>A0AC62A5C1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribosome-binding GTPase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2220070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="XUY36883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1000" mass="107704" checksum="3C4B711ADB733FD9" modified="2026-01-28" version="1">MEPPEAEAATAAASSSLAPLSTDDDIVLDTPASLLPCMAAWGASASELRQATQRAHHERRRGGRTDTVHEPAAPEESEYAHPAARGVGQDVIDLVTDVFTAQRDAEIQKRREVLYELTHPNPVDYTYNGKLVPPPPLSFGQVTEEARSLGNRMMLGQTYSLVRQAGTRASDDDLDVLGNTANAAGRGAATATTVSPASSVETGLAAPCSTFSPRHAKGYGERTAAAPYRRRAHDTNIFRGHNYFFEIDELYQEVALVGRACAGKSSLLNALLGQQVAKTSSMPNTTRKISFYQSVTPEQLHAFHAREHHNQLVKLPGGGLQLTFVDLPGYGIEGMSDAWRDAAIELTDAYFGVRRSVNTVLYCMDCERGLTKTDIKYLEWIENVHGTCFVVLTKCDSVPHSRVCSVMRQAYALITRHRRKYRKVFPFILPVSAKDGTNMEVLRGLITETSGIMPGDKLRDLLQHKKATFTHMALLKEVGRIDAARQLERSQAKAYFQLTRGGLGVSAGAKPPLEVHRSERPSAMRKRDGSGGASADVQDTSAERSAAPPLNADFSEAAAPPSGVAPGSRHCRYVLPLGSGTADAEAAALLSSCASDLDAADDTADVFPTESSMAAAAAEGRRERRERFLAWRRVHPLGTVSPSYDAIHGEVSCDATPPLAAPGLETGLPGSGRYRLNTGLDNPRAAHAVVELHGEPGVPVGECNARGKGGEEARHGGCDSQAQNPRDPALVAAGGSLHSLPTVLPIAAASHGWCSSVIGLSDVGTGSNIAPGADASAVPPAMGPTSPLRCASTGAVSRFVDVMEQYGRQHRVALSAKQKRKEERWRRRGGGGGLLAEDASGRLSAYRAGKPCGPALVPTNTDVSRRQAEWRAEQLKTLLAKESPEAPWAALRQLRRTIQARAEETALAGMRKKEVAAYVLNAGRVTASFEKFEGEVTAAKYMNETRQSPTLRSQQQMHLNATAKIGYRSMPPGLWKRYGEKDTYWQTPRVLGRSEDESHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5S0</accession>
    <name>A0AC62A5S0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histone H3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1620200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="XUY37031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="66" mass="7238" checksum="D87F239EB5F19D1A" modified="2026-01-28" version="1">MPCARCRACRRRGGPALPEQRDPGDPGGVRCVADGCHEPGQHPREACVTVRPKDVQLAVRLRGERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6D5</accession>
    <name>A0AC62A6D5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Beta tubulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0820320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="XUY37312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="443" mass="49831" checksum="AF2AEE5526A767AD" modified="2026-01-28" version="1">MREIVSCQAGQCGNQIGSKFWEVISDEHGVDPVGSYQGDSDLQLERINVYFDESTGGRYVPRAVLMDLEPGTMDSVRAGPYGQLFRPDNFIFGQSGAGNNWAKGHYTEGAELIDSVLDVCRKEAESCDCLQGFQLSHSLGGGTGSGMGTLLMSKMREEYPDRIMITFSVIPSPRVSDTVVEPYNTTLSVHQLVENSDESMCIDNEALYDICFRTLKLTTPTFGDLNHLVAAVMSGVTCCLRFPGQLNSDLRKLAVNLVPFPRLHFFMMGFAPLTSRGSQQYRGLSVSELTQQMFDAKNMMQAADPRHGRYLTASALFRGRMSTKEVDEQMLNVQNKNSSYFIEWIPNNIKSSICDIPPKGLKMSVTFIGNNTCIQEMFRRVGEQFTGMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATVEEEGEYEEEQEAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6L2</accession>
    <name>A0AC62A6L2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATG8/AUT7/APG8/PAZ2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0920140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="XUY37331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="124" mass="12747" checksum="547644016555283B" modified="2026-01-28" version="1">MSAYVSSTPLEARVARCASLRATNAVPVVVEEAQARGGKAHFSALPRETTAAQLVAAVRAFRGVAANKPVTLTVAGCSVSPSATLGELHDACKQADDGMLYVAYTAERSMGAAVCTPCASCSWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A728</accession>
    <name>A0AC62A728_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0420090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="XUY37426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="522" mass="52693" checksum="0F3DC9132BDCD79B" modified="2026-01-28" version="1">MAPLAPRCCAPALLCAVLVLAAVLVRAESVTVTDDLTMSGASFNDYTMTLGLASSTADVVTVQLMNSQVSGKGLTVQSSGDGLASSARLSMSMLLTTVTQAAITFSGAMPANSDIRIVSTIGSLTSAQSLFDFSGLALDSNVTVTVENTAVTWPKDSINTGSIVLISAGSNAIGIRNLAALFVLDAVATNGASVVRVDAQSSFPVSKAAVLAIDYGRCEECTGALVSINAPLVVDGSSMFRVTNCKAVGASKGLLASAGSTTVSGKSVYLVSDSAVESVSLFSFLTGIEDSSEPYPFTVSGGSTVSFLNLEAPSTGITNQDTLSASADSKVIGGGCVIKGVALNTAEVYKSNGLAVTTVVDRQGASGGTCANAKCIPGNTGAGAAVSGTDPCTCQCSSMDYNPPSCSTIVDPTQNYNPTDVCVVPNCITCDRLSPSTRCTQCATGYILTSDQRCILPTTRPPVCNVPYCTQCVTGSGSRCSTCHYGYTSINGACIANANAAAGAHTVALAAVVCVAAALYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RGW2</accession>
    <name>A0A088RGW2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_020020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009371">
        <property type="protein sequence ID" value="AIN95182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698147.1">
        <property type="nucleotide sequence ID" value="XM_010699845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RGW2"/>
    <dbReference type="GeneID" id="22571812"/>
    <dbReference type="KEGG" id="lpan:LPMP_020020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_020005200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_020020"/>
    <dbReference type="eggNOG" id="ENOG502SCAN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272526at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN95182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="194" mass="21076" checksum="02120C7847C08A7C" modified="2014-11-26" version="1">MLTPLSMPAPNTVAVRVPFYYQANEGSKGAEMRADRASAPMELVFVTNVFIEVIAFGTRFFWVHISESPTSQYVPRLGTCSVAVGLQLSRDDGRGSISSSLLMEYEATRQQDTSAGANSSVQSAFSTSLSQRLVRGIAKQLGTQATVYVNCAIEGERCLSLLGTDGGSGFDMTFQFGALVYRETFQLVAQQWDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RH34</accession>
    <name>A0A088RH34_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain-fatty-acid-CoA ligase, putative</fullName>
            <ecNumber evidence="3">6.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_010530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="CP009370">
        <property type="protein sequence ID" value="AIN95153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696695.1">
        <property type="nucleotide sequence ID" value="XM_010698393.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22571782"/>
    <dbReference type="KEGG" id="lpan:LPMP_010530"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_010006000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_010530"/>
    <dbReference type="eggNOG" id="KOG1256">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24094:SF15">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24094">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="594"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="1066"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="753"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="885"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="939"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="466"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="786"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="799"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="825"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="835"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="885"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="939"/>
            <end position="954"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1582" mass="168690" checksum="EA55172FDCB40577" modified="2014-11-26" version="1">MGTLLVTLLQCRNSQSLYPNLRATQHNHYTSFQQQCSVPLLADARHYNQHSRQDSPLIATTTTTTPTGAVSDEATERTAVASRAGETEKGAPPPTSFAGAVSDMSASDKHVVNPPEVRNDGDNTGAGATDVDVDAAAEISRLLLTRLLATKSVPIPPSASQVHPQLHHHAIEQPAVDNALYTSSLPVVPPLASAGVASSPSTTPPMQPQDRPPSPSTMVFMPSATATAPLTPAASPRRQRSNNAVPPLSMLATATSTQTPTPHLAPAGGLTISPPAGAPVAKDCDSVKRLVLPGDALHCRAPPSTCGNAAAARTDEEEDAGGGDVDEDEDEVGPMDCADAFQYFFDEDEKAYRDVESVVYAAPQMARVPLPTLRDYYLNQHTALYTEKASSAALTTQSVPSVLAGSMAPTIPSVFLLDTAANAGGEDMTIKVATWSPTPPLPTQQQPQKGLHDPQETPSSRRDAPRTSTTRTLLTTGEGLDSTAHDTGRFISLVEEMAAACRRIGAAPLVCWRSIDRVTELPPEDPLWRRLTNGGGGGGGRVDNARGEIEDDTSCPPVSDVPRKRCSHPSAPLVGDGGSSAAAPLPSLQQQQQQQDQQHSEPPSLYYLGPQQYMTADVWWSRVEAFGFGLCSMGLRPGDLIGIVEDTRWEWLVTCYAAWSVGLVVVVFDSSARTMARAAMDTAPEMKALVCSPVVHRALRRHFDDAAAAAAAAARSARAPAPLTPTSVSSMKDYDGDEGDMYDGNHGACASGDAAGTVPPQWTSVQPRKKRHAHPSMFIVVRRSGPPRDCRSDGGDVHAAAMRSSASSDAAPGSWWSRANMREPQSSHRTHDPGVEGDNEAGDEEGEDEEEALWWSDVLMHGEKKLRVWRQRKLREQRLQQQQQQQQARLRYQQQQRCARAGGGGSGGAAAPSSPSGTSRHCLRGSSGLGMDDFYGSTSTAAASQDGSTASATASAKPGPTAAVSDSGMSTAQAASDSAKTTPIMLLGAAAAKGGKSGSSTRLSVNAPARRVLVPMEERKALTEFPRRRTCGGSLRTMPTSSLLAGNAALTGTPPMAIKDGLPRLPLAPLRPDDLAFIFYTEGDPKGVLLTHGALKASVAAHHEYLNSTDIGGSTAESTGRGGQGNSRIARYTTAYMPALRSRSAPAGRPSYMAYLPLHDIGEFVAETAALVRGLLVCYGTRRTLFDTWARPHGDLTEYRPTVFPALPATLARLRRTVESMVSTGYRQLLFEAAYEARRQAMRRGLHTPFLLTTIFAPSRELLGGRCRLVLVRGGPGAAALHPRDQEYLSVVCGVSLVQSYGVTEASGCGLQQAYCSTQLDSIGGPLGPVHVKMRDVFATAAAPSSGGGCGWSHQSERPTGELLLRGPTVMAGYYRQPERTAAVLEKSGWLHTEDVVERCPDGSFRRIASLRPHHATTSNGHCIALEPLEALYAQHPLCLKGGVCVLVHPYRRYVCALVLTDEHHLWDFLQTTAAAVARPASSYSPPSSSTSQQRSWILSAIGEWPQCLGDSALNQVAATSLVAWATQHGGIAPHECVRHVRVLHGVWDAAHYTRTATGRLFRPAIHQRYSGVIQELFADED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHJ3</accession>
    <name>A0A088RHJ3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_040310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="AIN95358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703680.1">
        <property type="nucleotide sequence ID" value="XM_010705378.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22571990"/>
    <dbReference type="KEGG" id="lpan:LPMP_040310"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040008900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_040310"/>
    <dbReference type="eggNOG" id="ENOG502SBTB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="438641at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="813"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1340"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1450"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1573"/>
            <end position="1612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1748"/>
            <end position="1794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1341"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1598"/>
            <end position="1612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1781"/>
            <end position="1794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2108" mass="224350" checksum="5C5C9B47B705CC1F" modified="2014-11-26" version="1">MSYPGPTSSQKGEVVGDACGGKNPTSLSLDVPSPEHAWTGVGPAHTLDDTPAGLSVGVATAPVAFLRPPNAAAGRPLPSFAALLPTRRSPLSVDTTSSDSAAHEPRQKKRDQATVTAQLAPLHLTSKPSFPSVPGSGATAQGCGEGHEDAVASCLAHRQAHRTHLAVSPLNSPLFVPSTASKSRSRNKHGLADSMSFPQRAESPVAYSFTDLFVGLERPRLYGRRQRERLQHHRHHGRTHADDVVDVDGQASSSSFLSSSSLSLDHISSIGRHDGAFSGENTTKDEDGANTPTVYCSPQLPHWWRSIVTPVPGTRVSLRPDTCRLEFWWIDRLGSEAYEIIRIVLKHSLEGVVLRRSGKAAVVVEFRISSKLLKSTDYVVTRRSREQRDGSPSPATDANTSESPSVLFMDSVCSPAAPGASLTGSQTVCAAEAATVVQHSPSPTPFTSSAPLDTSTVTLGPVGNQHTRSGNRGSKAECRRIESAEPAARVANATTATATTTVTTTITTIAGGTSSQLTSPLCFPVSPRRATAKRVPEGEDETTPSTQAPVCTPSPRSPSMHLQQPQQSEATGPSTTLLPSAHLPLSFTGDSTAGNMTRVMAAERIGGNGEEEVDATSVNGGGGGESTRSLASTNVTTNPNGSLSNVLATAMPPVRHLIQGSPPATKLDEAHDMNIIGGADDDVASREPGSPIGTQGNPCTLSHRCSSPPLQSPCDKLALTVKVSPMTTNSVESESLYNHIGNRSGGVATAGGGEGMFLVHIESHSKSKTVNMNQQRSGSPVVAPPATLASNPLLSVSGHRYPALHGSFISDWQHDSRRSQQPPHQDPLGSPISAANSYSDTIAKVAAAAAEAARLEDATVPTTAAVAAPSQQRRPTPLDTSQHVMAEDDDSVVAILTLPIAMCTPIVVVRLHAMHILHPLLRAMTLLDSPAFSASISGDYRYSDNMDTESTDEALVTAVRLSNVTPASSSARDASSPDYTGAVRIVSEAIELLKQEKSMEEAPPMTTTPNGHAPTRARDLSILYTVRSHLLFHASLTCLHDSLHDAEAAIRCCPARDHINATYEVLTANLISLGNISQVEDLAGFLRHRRRAVSPLLLRLGRVTQVMVSYASIFLRQQLPTSTLCLCVGGDAGTMQYSGTIMENASLSPHSPEEGGVLHCPLGDSPNAAGIVNPASTGQPRIPSLHPTPQPTEHISFSLSHRVDGLSSRADAAANTATPLQTHTLPCEVCPLLFGRNSRTLHAADEPPRRPPLSVSAAGADSISAGLAQHYRSPTTPRPRSPFCGLLQPGYPFRPGTDVCHRRLFLLETLLPSMNPTPVSRLPLFVSRGYCGATGRRSLHPISQPSSTRATISGGNNNATPSSVVIVQRTMSKRRVRAEDFMHDRDSMLALLAATADTTTRWGTVPIEYFCRHIRLSATRRIQKGEAVLMERPAVLMPFWPLPSPRSASASTTATTLRGNNGTSAGVSNRSVNVPSVPSCCAQCGRQRLAKPVNCPGGCHSVYCSEQCQQLALRLYHVVECGGVPPDPNNAHVLEPGDDVGARVRRAVTALQGVFSDWNSYLHQFVPYDTPNTRLTTPHTAGSPGMAPVSPSSVGEMPGHDASQHQSGDAKGKTVGQAKRSCVPLSILVVTAMRVVARLGAMLLSLALPLELLPQMQSHPAWTAERHAMIRAVARTLRQRGLMVPATTTSAVPGVNAYCTNVDPHRLLLLEVLLQQLSVPFFADFNYSASSTLWEGLRQIPCEVARSSGNPVAATGPEKPVASPVDGSRPDMFPNPPFPHAPSSAPANAQQQQQQRNWFVELTPTQLEMVLGDLHSMAHRVYQVVAKELVDVPSLPLSGAEAEENNSLEWGLPGRWSCVELLGFLNSTRALHQISDFALTSWAVVYPRDMEPPNVAAAMAADGRNVSQALSIFLGDDHSMKIHHHHHSNKNSVIANEFSHASPSDIPNTAAVPLAVISPWSCLTVDLHPILGNVHSGIIYSRFMVEHEQRRRMLAYCAAAAGRRGGDGIGGGSGNEDSFLSVHSGVSTSAATLLTGDDSARTGSLRDSFNLQLLEETARRSCSNLHLSLVYTPSKDPAVLAVAKKNITLGDVLWWESLNCREYLSALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHN5</accession>
    <name>A0A088RHN5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nuclear receptor binding factor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_050500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="AIN95492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703814.1">
        <property type="nucleotide sequence ID" value="XM_010705512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHN5"/>
    <dbReference type="GeneID" id="22572128"/>
    <dbReference type="KEGG" id="lpan:LPMP_050500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_050009700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_050500"/>
    <dbReference type="eggNOG" id="KOG0025">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7482721at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08290">
        <property type="entry name" value="ETR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000892">
        <property type="entry name" value="Nuclear receptor binding factor-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000040">
        <property type="entry name" value="Nuclear receptor binding factor-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051034">
        <property type="entry name" value="Mito_Enoyl-ACP_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981:SF2">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN95492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="340" mass="36081" checksum="F891849244D81B60" modified="2014-11-26" version="1">MSKVASAGWRYARCGPIAQVLTYEKFDITPGKDEAVVQMMTAPLHRVDAAVVNGTALGRKRVNMGLFCRIGGCEGVGTVVRSPAAAAATSSPVKEGDTVWVAPLHGTWATNIAVPVTHLHKINPRQAQMAATASNFLVAQQLLDGYARLQKGDIVIQNGGSSLTSLAVSALAKSYGVKVLTAATPGDRFAAAKQRHSKYGSDVFEYNGAGTRAMQAAVGRHGATLYLNGVGGRYFDSLLKCTGPMAHVVTYGAQNGFGLLISGSSLIYNEVTMSGLFAPTYLNSMSYGERQTKLEFVLKAVQEANISYPMVTAPSLEKLPEVWDDVYVKGGRKALVKMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHY7</accession>
    <name>A0A088RHY7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_050710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="AIN95513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703835.1">
        <property type="nucleotide sequence ID" value="XM_010705533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHY7"/>
    <dbReference type="GeneID" id="22572149"/>
    <dbReference type="KEGG" id="lpan:LPMP_050710"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_050011700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_050710"/>
    <dbReference type="eggNOG" id="ENOG502SKI2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265509at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="500"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="765" mass="83023" checksum="01E87FF769D7107F" modified="2014-11-26" version="1">MSTLASSVLQGQREKSAWLEEALDTCIVAYESHRNALENVYSQLTTWQQSSDQGCIHISPVAMSELLKDINDVLQQCALQLQPMDGATSSAESPVEQAQPEHRFRGAHLQSDNASSVSTYSTRRNKPLPAPPQQEQHLLPRSASDLSSASQSRGTENDLQASSAMTESQRRLQPSPMLQYRPFSTSRSSMSSVLPAVNESAVTDPSKSPAQLDNTAQKPMRPPEQRQQRQQRQQAAAAVQSTRPRTPPRNWHSAAPTPRPTIDDGHQTGSAATGPRVRSSGGSTPLSSSQRAEAEHVKLSSQEQRTATREDAKANGTYQHLFGTRSCNSDSTGRHGPPSTPSVTSASPADAGSAASQHPPPHREVQRSQGYVSEEVGTPHHQSFSSAAERRSSTVASCSHFDSCRFEFFETDQSAGSAAAAASGHQTAAVAFHYSHQTPSHQQSNDGCGSLSQTSIALRDGVPGATVAAAASLSYPSSSTLRHPHQMLSGDEKKSEVGKQRSSSAAAAAEAQRGEASQVGSVGLVHTPSATPQRDSSSRTTVAAPPPPQQQQQVSIERESLNLPLPPQQPGKRRPLRTSSQRITPRKLNDSSQVESTVYHRSASPSTGRQPLRADAPEALCFMEREDNFLVKRRLAERKAMHGDIHQMQGNAERDANPFITAGPGRQLVANGGMTGKVEAAPALTAVEEQLISEHTVLRTQLERMQMELYIAVMRHRERGNEPRYTQLNTRMKRVMKDLSRVEWELRVVRNIDCESHSKSPAKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJ48</accession>
    <name>A0A088RJ48_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GPI-GlcNAc transferase complex, PIG-H component, putative</fullName>
            <ecNumber evidence="6">2.4.1.198</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_080160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIGH family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.198" evidence="6"/>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="AIN95825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704147.1">
        <property type="nucleotide sequence ID" value="XM_010705845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJ48"/>
    <dbReference type="GeneID" id="22572478"/>
    <dbReference type="KEGG" id="lpan:LPMP_080160"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_080006400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_080160"/>
    <dbReference type="eggNOG" id="ENOG502S555">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6256716at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017176">
        <property type="term" value="F:phosphatidylinositol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044215">
        <property type="entry name" value="PIG-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019328">
        <property type="entry name" value="PIGH-H_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15231">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15231:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10181">
        <property type="entry name" value="PIG-H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="221"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidylinositol N-acetylglucosaminyltransferase subunit H conserved" evidence="5">
        <location>
            <begin position="376"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="151"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN95825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="515" mass="55060" checksum="574A4802B6BFA3D8" modified="2014-11-26" version="1">MGPRRSKVVPEPLFYVEGTTTMVATKTDSLPPDASASAAEPSASSVAQTVSTAPVGHLQNGAQRPVVFNKAASPILPPGATTMGSAVKAFSPNLNVYHTNTNGVTLTIAPRTTVLVANHVANTGSVVRLEQVDYSKAMRAYRVCRQEGDIVAEESPQGRHTSSAISMAQLPRPTSPQGTSSSYTTRPSSLSGMTSLKGPASFPAYDYEAPLGHKPAPWRVVFLRLFGAADMVLLTVVVACFLVVVSQLRVVNSYRTDVQGMASSSSSLSWLVVALAAFSSGPAGVNGIEALSDSPLASAERMRQAITGGSQTMSPLTAAVGIPASDTDGVVSGSYAQAKGTPALDTSVTFFLLLLSVFLLVKRLSGALSRVYVEEVLVMRGVGMQFSAYGIFNTLRYRHFVDLLMLRSLIIHDAFFRYQPIFFLSSSVENKAERIVYFPDTLPRLAVLRPVLNGIRAVLYGEPEEGPSLAELEDQWKSAVDFSDGDFFMEDSFAEDTATTPDDACFSEATDHDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJE2</accession>
    <name>A0A088RJE2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 2 subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_091080</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN96023.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704345.1">
        <property type="nucleotide sequence ID" value="XM_010706043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJE2"/>
    <dbReference type="GeneID" id="22572678"/>
    <dbReference type="KEGG" id="lpan:LPMP_091080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090016300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_091080"/>
    <dbReference type="eggNOG" id="KOG0466">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1045173at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03688">
        <property type="entry name" value="eIF2_gamma_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15490">
        <property type="entry name" value="eIF2_gamma_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000009">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000075">
        <property type="entry name" value="Translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050543">
        <property type="entry name" value="eIF2G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015256">
        <property type="entry name" value="eIF2g_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044127">
        <property type="entry name" value="eIF2g_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09173">
        <property type="entry name" value="eIF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN96023.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="479" mass="52658" checksum="89283CD5019993EF" modified="2026-01-28" version="2">MAEEDIADFTLDDENVIDTDQGLAKQDLSKINLDELNVDTFEVMSRQATINVGTIGHVAHGKSTVVKALSGVKTQKFHREAVMNITIHLGYANAKVYQCETCPRPTCYQAYPSSQPDSTPCPNCEKTMTLKRHFSFVDCPGHDVLMATMLNGAAIMDAALLLIAANESFPQPQTLEHLKAVEIMKLRHLVVLQNKIDLVGEVKAHDQYRQVRAYLDNIALNVPIVPISAQLKRNVNYLLEYLLHIPMPVRQLKAPVRMTVVRSFDINKPGEGDIERLKGGVAGGTVTQGVIKVGQVVEIRPGLVRSRSTNEQGGRFTYSPLKTRTVTLKAENNVLQYAIPGGLIAVGTTLDPTLTRQDKMVGNMLGEEGTLPEVYCEIEVQYYLFSEMVGAKSKDGKSTAKRVQKLNVLESLQINVGTLTAGATVLNITQDPEIAKLELVTPVCCSTGEQVAISRMVDKTFRLIGWGTIRRGVPMKQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RL37</accession>
    <name>A0A088RL37_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Inositol-3-phosphate synthase</fullName>
            <ecNumber evidence="7">5.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">INO1</name>
        <name evidence="18" type="ORF">LPMP_141350</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10716"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="5.5.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the myo-inositol 1-phosphate synthase family.</text>
    </comment>
    <dbReference type="EC" id="5.5.1.4" evidence="7"/>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697365.1">
        <property type="nucleotide sequence ID" value="XM_010699063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RL37"/>
    <dbReference type="GeneID" id="22573402"/>
    <dbReference type="KEGG" id="lpan:LPMP_141350"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140019200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_141350"/>
    <dbReference type="eggNOG" id="KOG0693">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2887at2759"/>
    <dbReference type="UniPathway" id="UPA00823">
        <property type="reaction ID" value="UER00787"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004512">
        <property type="term" value="F:inositol-3-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000040">
        <property type="entry name" value="Inositol 1-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000334">
        <property type="entry name" value="Inositol-3-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000069">
        <property type="entry name" value="Inositol-3-phosphate synthase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002587">
        <property type="entry name" value="Myo-inos-1-P_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013021">
        <property type="entry name" value="Myo-inos-1-P_Synthase_GAPDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11510">
        <property type="entry name" value="MYO-INOSITOL-1 PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01658">
        <property type="entry name" value="Inos-1-P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07994">
        <property type="entry name" value="NAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015578">
        <property type="entry name" value="Myoinos-ppht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0398">Inositol biosynthesis</keyword>
    <keyword evidence="14 18" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myo-inositol-1-phosphate synthase GAPDH-like" evidence="17">
        <location>
            <begin position="307"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00070063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AIN96712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="526" mass="58207" checksum="2E21C1EE76C6E83C" modified="2014-11-26" version="1">MPEVRVRSDKVRYTPDAIETQYDYTTTRVSCDAKGVVEVVPVIHRLMFRTERKVPRVGVMLVGWCGNNGTTVTAGILANKMGLSWRTRRGMQSSNYFGSITQSSTINLGMTRDMHETFVPLKDLVPMVSPNDFVIGGWDCNSMNLGDAMRRAGVLEVQLQDALYEHMKKLRPLPAIFDIEFVAANQKERANNVLAVRDRWAAVEHVRNDIRQFKAANHLDKVLVLWTANTERFSEYRDGIHDTADNLLAAVKCNETEVAPSALYAIAAILEKCSFINGAPQNTLCPGVVEMARTANVFVGGDDFKSGQTKMKSALIEFFVGAGIKPECIASYNHLGNNDGYNLSSPKQFSSKEITKSNVVDDMIRSNSILFPKGTPKPDHCIVIKYLPYVGDSKRAMDEYTFSIFMGGQQTVVLHNTCEDSLLAAPLIIDLLVLTELMERVTISASDGLQSPPPASFEHMETVLSILSYLLKAPAVPDGTPVVNALNRQKAAIESVLRAMIGLPAESNMLLECRVPFIREEHVNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLZ8</accession>
    <name>A0A088RLZ8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Snf7-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_160890</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN96963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697616.1">
        <property type="nucleotide sequence ID" value="XM_010699314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLZ8"/>
    <dbReference type="GeneID" id="22573667"/>
    <dbReference type="KEGG" id="lpan:LPMP_160890"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160013200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_160890"/>
    <dbReference type="eggNOG" id="KOG2910">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="441172at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF5">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN96963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="25035" checksum="F5AFC282D4D3E8A7" modified="2014-11-26" version="1">MGLGESKPKLSQLTEKPAKSQITPSDKARLQLKLQRDNVQAAIRKYERVASLEHEKAKEFMRAGNKRKALYCLKREKAQQSQISIVTDMLDNVQRLIDTVEFTQIQGEVVAAMKVGKCELENLNKMLNIDDIERLMDEASESIEEANQINAVLSQPLAGVQDDDELLLKLEQFGETQKVDQELPNLTVPAHLLPQKESGLVKREEEEEDQDADALHVRQYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMA6</accession>
    <name>A0A088RMA6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_120160</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the APH-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009381">
        <property type="protein sequence ID" value="AIN96344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696997.1">
        <property type="nucleotide sequence ID" value="XM_010698695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMA6"/>
    <dbReference type="GeneID" id="22573022"/>
    <dbReference type="KEGG" id="lpan:LPMP_120160"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_120006400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_120160"/>
    <dbReference type="eggNOG" id="ENOG502SF3Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273751at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009294">
        <property type="entry name" value="Aph-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12889">
        <property type="entry name" value="GAMMA-SECRETASE SUBUNIT APH-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="314"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="327"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN96344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="459" mass="48327" checksum="C7253A74F253AE67" modified="2014-11-26" version="1">MDYTLALCMSLLYAPHTVLCGLALLWQPILLVISLLASFVAFLPLVITGLVFQALRWTGTADVSTAAGVVVTHFVLQNVARVGALNLCLRAQRLGWHHGCLLVRSRFPLVPLSIAIGAGFATTSLLASGGVLLAEAWGVGRGLSEGGHTASSSTAAAQELDFLASSGSCARLPRLVQSCFQQTFFSCGQVAWTVMMGQAYAALWPRDVAVGFSEHTACANGADEPATLGVEMAAEAEEHGSAPTPWALRAEETLRQDFAGLLVADEEFAPVVTDHMPETAAYSWSSGHASSTARPKTREEAEVNQYLPCSAMGSESGDAGAVADTVPSATPSMRETTRSSTVRKHQNTPLSPSPPAGVVGWLVADSVLAQRLPTAVLTGAAALVLHLIFVLPPLTTMAADSASARNTLIPSSARRSNSCLVGVSLQCIVTIVSLVWGLWIVELERHTSTYMLLPSSTHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMH5</accession>
    <name>A0A088RMH5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein kinase, putative</fullName>
            <ecNumber evidence="10">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_170700</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="10"/>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697761.1">
        <property type="nucleotide sequence ID" value="XM_010699459.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22573813"/>
    <dbReference type="KEGG" id="lpan:LPMP_170700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170013000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_170700"/>
    <dbReference type="eggNOG" id="KOG0667">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="437530at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF22">
        <property type="entry name" value="DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="775"/>
            <end position="1577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="248"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="378"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="454"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="505"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="630"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1008"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1105"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1222"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1470"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1659"/>
            <end position="1679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1745"/>
            <end position="1810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="380"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="454"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="638"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1023"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1109"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1232"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1477"/>
            <end position="1493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1745"/>
            <end position="1762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1781"/>
            <end position="1793"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="809"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN97108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1810" mass="194815" checksum="069BCF2854C74DC5" modified="2014-11-26" version="1">MYEGASSPTTLSCSGGSSGMHLDEPDASHSQLPLSSKALSPQLTPSTPAMQRLPHQGAPPSPLQQQELNPPMTSLSRRLWNQFQARELPYPAQRDKGSSAADTKIRAPAQFSMSCESSSGNATNPQRSMLLGLSTRCSENSPAVAPVGSPPSSLFSTPMTRHLEGCTPKESPDFRTLFTPYTSPPSLAFTAESPENADSNKRMWNVYRRQNDWMKSSTVDCSILTHPQVHSAGLDSIPGASLATTPVQQQANVSSHKPIRDTSGRTASQTMDPKYNGGTSTVARSPSALAAATPFRDLDQLYPSKSAMFPTSSREPWPQRHIIFPTKPLSPMRRSESHSTGRSPFSHPLGGAHQLFRSIESASVSKELLALNHDVVRATSEASTSSAHRTQSSRQCSGRRYSPSTSPVHDKDYICDFSTASADQRMPLPILKRQPHLCSSGSISGRFGGPSLVSTAHRSVNRSSSSHTADRSGWSASSTPPPAVMGVNSREDFVRRFGGESMQNLSALSQSHHQQPQQPPSPLPTTLSLQPRTLIAGIMHDHSPCSSPTPTEPTTAALVRSPEWHESVERSVDSCSCAPSLFAAVQQQHRPLLSTPVMDHSAEYSTASTQEWAPLGRRVSLRNQHRRPVANASIFTAGGNSSSNTRRQFSYNSVSPAPAHSNEESSTPLKLPALPPPPPWSPGEALHWMRNRLTLQEQEEMLACDVVYYCGPPVHPRTACGVTDCATPLPLVHHTVEKITSASSLPKNKGEVVSSTAPLASYFPITLGMHISFRYEVLEVLGFGTFSVVVHALDHAALPLSPERHCALKLIRRELLYQNAAQAEWGICEQLKKCCAGMRRCSGGCFGEGASGATADYRAKPFVHHCKPSASSLPSASPRLSMADQRTLRFASVLTPRSCFEYRGYHIIVFPLLGFSVRDAVELRRELREAKADHAISPSPFPLPADVLLVQPGDQARVTLPTEVVNSVLAQLVRALHFMHHCAHILHGDIKPENIVFVDRSMSGRSSSSISGHFAESGGAASQQPLPRLPSQPQHLQAPLPCTGDAGPLPTPLSLYPFRRLSFDPPPSLLSSAAAPSPSSSYSGTIPRRPHVTEYVERHPSPEVGDCGSANSSMSTCSSSLPPLTAPYPPQRDTVVTDGPDRGITMMSRSHSLQHLGCEVTSSAQRHPSSGDLLNQCITGGVLVSLTGHSLCMAGSRTGALTSSPLSTLTCAGVVGGSMGGGTGDTALSEAPRSSNGSPRGASASPTSRPGHDSRGGVGGGGDESSSTVTSSARARLTYALPYAMAASTATMASSRIALIDLGHAHLIPPGTTGTSFPLQSPSYRCPEMALRLPYTTAIDMWSVGCVLYELHTGHPLFPDACDDVMLLQSAVRTLGMPDPAFLATVKSCWRRYKQHKLSTTAAVAHVHGDVASPSTSPQKLQRLLPQLHPQEPQLAVDGEDVKQDEEVIIVERCWLQFIQVLNDAAGHQREHDQRLKAQQQWSTPSVVESSQRSPREADSPLAKGSGGTTTWETAEQLALLQVMFPGGQAHEPDQCFSLPSKCDWGQYAWVDFFLGCLYWDAGKRLTATEAQVHPYLASHFAPEGTPATAVTANNNTASSAMDKRDVAGDPAMSALGLSAGSSDGAPEAPVTAIIRPKQCSGLYYLRHHPLTCRLFQSAPETASQPRSPHSNRSTTSNDAESLLTPLLMKPSAIVPFELPSSNCTAPSARLWEEHRELLPHCYDSALDIHSTPQIRTERLARSPYHCNDHRRNPFGSTERHPFRAFSESDQGIESPVEVSAESSIRGNLASTQKPRRDGSTSEVMVLPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RN00</accession>
    <name>A0A088RN00_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_171420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697833.1">
        <property type="nucleotide sequence ID" value="XM_010699531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RN00"/>
    <dbReference type="GeneID" id="22573885"/>
    <dbReference type="KEGG" id="lpan:LPMP_171420"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170020700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_171420"/>
    <dbReference type="eggNOG" id="KOG1091">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27140at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF337">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="32"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN97180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="486" mass="55580" checksum="FC30A8C53B95A941" modified="2014-11-26" version="1">MNDLSFFVLQHQKRTLTAQLLRDTLDFAKPHAEEGVLFSWRWHFFLGTLPLPADDDVQLLDSRAACKRWRQQWQDAARRLDQSIREMPRKTGKTIKFGESSTDSEDSSAPPSAVAPITALDTSRAEKTVNPLAPTSESSYALQYQADMVRQAVERDMSRLCWNVPPFHDQESKEVVADILLKYSLMENRDYMQGLHEIVAFLYYACHRDKAVGERFGREHPALRSAAFFDLFELVYADLPAAVYVLFRRIMSDEDGGIFLAKWYYLRDQRSQSGVLLACERVQQDLLTRVDPGLQHLLDAVYGIQSVVYLVRWLRLLFLREFPLEQSLRVWTAVFCERYVIVEEQKAPFVLDNSIALYFAAQMLRHVRDELVIDAGGALQVLMKYPPTDHVDDMLYAAAMSNCDSPLSRHAKAPRLMDPKDAPVLPAEVTLHQGEVLSRVIGSLEQYWVCGANATAQQQELTTEMYTESLARLKKVRDVLLYGMGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNY0</accession>
    <name>A0A088RNY0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_203010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698504.1">
        <property type="nucleotide sequence ID" value="XM_010700202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNY0"/>
    <dbReference type="GeneID" id="22574512"/>
    <dbReference type="KEGG" id="lpan:LPMP_203010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200036000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_203010"/>
    <dbReference type="eggNOG" id="ENOG502SMND">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="262751at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="476" mass="52219" checksum="974E38403C9FB28E" modified="2014-11-26" version="1">MTAHDGLFVGRLQEDVDASVRCLSQANTLTVDDAAPRLLSAITNYTKCAAATIHNSEKHDEVTEEAAALSVMVHMQRLSLVLNAVDTPARSSASASKSSMHTCVEEWATWLLGLESQPIAVVSKVALCLPPLQACWRGGYALGGARSTYVYRIEEAIGSFFSRAARKCVAEWTTYGTPLRTLLPPLRLLTTYARFRWARSCFRELGHMVSDGDLGAAEVRKAIAGATEATQGQQSKDIDFLSITNEVESCHVSKVSREVLLHAFKAIDWRVGNAVPTVKEVAPLVWCLFLRCRSYALHNHSLNHFSDFFAYEASARLVAQLLRFTVDGVRVCLERQAAEMHVARAEQLFTCDIPCLVLLTRLWFSWIGLASDGAAKLLPHLERSLRQLVSSTVKLRGIAEKKAPAPSMVAAREGSSGRTSKTEQEQLFIEVAWKVTPLSMSEIMSSTAAAPWTAAFARASDVRAVLDKRTIVALVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RP01</accession>
    <name>A0A088RP01_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LPMP_161140</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10 11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10 11">Cytoplasmic vesicle</location>
            <location evidence="10 11">COPI-coated vesicle membrane</location>
            <topology evidence="10 11">Peripheral membrane protein</topology>
            <orientation evidence="10 11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10 11">Golgi apparatus membrane</location>
            <topology evidence="10 11">Peripheral membrane protein</topology>
            <orientation evidence="10 11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN96989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697642.1">
        <property type="nucleotide sequence ID" value="XM_010699340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RP01"/>
    <dbReference type="GeneID" id="22573693"/>
    <dbReference type="KEGG" id="lpan:LPMP_161140"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160016700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_161140"/>
    <dbReference type="eggNOG" id="KOG2635">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10266042at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051645">
        <property type="term" value="P:Golgi localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09254">
        <property type="entry name" value="AP_delta-COPI_MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14830">
        <property type="entry name" value="Delta_COP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000003">
        <property type="entry name" value="Coatomer subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027059">
        <property type="entry name" value="Coatomer_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121:SF0">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="14">
        <location>
            <begin position="297"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="139"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AIN96989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="535" mass="57914" checksum="9556272D202AE76E" modified="2014-11-26" version="1">MTVISAGVVSKQGRIVLARQFTDISRVRIEGLLSAFPRLLESSMNKQVTYIDAGTVRYVYQPIEELFLVLVTTTKSNIVEDLATLQLMGRLIPEYIPEGITEASLEAHSFEVFFALDEVVVCGKRENSTVEQIRVYLGMDSYEERIALEEKQRQMAEAKKITAEHARKMRERRMSGGGPSGGAYGGISSDDPNYGGFGSSTIAGGSMSMYSSDGGMETTYPAPSAVMNSHTSAPLKMSTAPRSGMCLSKARKADISSKIQKEMGIPASQAPGAPGGASELGVMRHNAMELPVAVVPQEAVNITIEEKMSAALQRDGEATSIDIKGELTVLVADPQHDHIKLMLAPVSEAFTFRAHAKVNKTLFASDQVLTMADGKPFPVQQPVTILRWRLSDPSITAPISFTCWPESSSITIEYELADPNMAPLQPVRLAIPLYGASPHDVQPSTGTYQVVDGQHVIWTIDVVDGHQNANGNIEITVDNEHGVNGEELFFPIHVALSSQVVIAHVGVMEVVSTQTGQAVHFSQQSRLVSDSVLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPF6</accession>
    <name>A0A088RPF6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleoside triphosphate hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_201660</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698367.1">
        <property type="nucleotide sequence ID" value="XM_010700065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPF6"/>
    <dbReference type="GeneID" id="22574375"/>
    <dbReference type="KEGG" id="lpan:LPMP_201660"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200021900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201660"/>
    <dbReference type="eggNOG" id="ENOG502QPRV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10267859at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044802">
        <property type="entry name" value="NADKc-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010488">
        <property type="entry name" value="Zeta_toxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31153">
        <property type="entry name" value="CALMODULIN CALCIUM-DEPENDENT NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31153:SF1">
        <property type="entry name" value="CALMODULIN CALCIUM-DEPENDENT NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06414">
        <property type="entry name" value="Zeta_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zeta toxin" evidence="4">
        <location>
            <begin position="809"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="500"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="608"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="671"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="519"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="545"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="576"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="609"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN97660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1065" mass="116655" checksum="9E6192C004C12732" modified="2014-11-26" version="1">MMMQSPPPYVPFVEYVLKALEHPPYMYVAKLAACCTMLFLTRENPELLEELCHKWAIRFAQDRLRLVQHIRKRASYCINSPDTTCDFGCDAKDSSEDTSANRCATHPPEQPIRDRDVATVMCCCDPDRAVEHLLSILNTLVPMYFSWNWHRADYVIQINREYEVYVREYVLPVCVDLAPEDGVDDIEHTPWLLPPHTYLDPTESVSSFYTLHSGVVPSSCVGSSRSSSFVVSSPLGTVAGTDLNRDHIVSTSDSSTAKGSDVGKFSFPSLPQDVTAASTAKGKPSVSIVGPLLPTFSPTSGKTAADDGASTSSPNAFPVGVQACSSALGCAVVPIRSPNVMSARAFNAAAVYGLRFLTLSNYRDALLSNTTGLVIVFHAKYSAKSNEVIDVFQKIAAKRLLDPMPTIAVVYAVAEPELSSLYNVGWFPTIVYTPPLRYQNRRHHSPSAGLHTRTDDAVQEITCKVSADSKRDGIAGTPAVGAGTSSTSLVPKGLVKGSARFTRTPSSPYLRPDLCVEDTSSRREVEWPPRRGYSPRVDSASLPKCRHEEATARRSTGRSDGEAYTTVGAARTEVLTPSPTGSNTGSSRSLPIRNHSEVYESVGAFAATSGEQPSTSGGNPADVSSPFRQALNTGVGGAPPTSAEILFSTLVSKRAQDHSIAALSQLSTTNLDNSGVHSTSGKEKVQPLGEHSGKMSLDSLKDTLVSSDYIIYPLDGVQTVSALVEWISSRGASVPRLRKMNEFFTRIKYIRQEEKFKRYRELHSAVVTLRRLQGCKDEFGVAGSASKCSKHTPSPLTLAPQQQQHHLLDQPVFIFLGGGMAAGKTTAVAALAKSSWWESHKEQSVVVNADEFKLPFESEMSSSQAHTHSTRAAENLLVKAINQGRSIVLDATMMWKPFVQQVVAMVRDAHLTLFKQGPGYNKETQIEEYFVAAKARNPALPMPYKIIFLGITVEVETAVPRGFLRKFQTNRGVPISTQLRSFKLFAENFTNYVSLVDEATLYNNNVFVKLEKGELPPVLAECNEKTQYKLLVHDEPAFQQFLRQQQINDEADNVLELYPTTPATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPL3</accession>
    <name>A0A088RPL3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell differentiation protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_204140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698615.1">
        <property type="nucleotide sequence ID" value="XM_010700313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPL3"/>
    <dbReference type="GeneID" id="22574625"/>
    <dbReference type="KEGG" id="lpan:LPMP_204140"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200047500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_204140"/>
    <dbReference type="eggNOG" id="KOG3036">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1183224at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000334">
        <property type="entry name" value="Cell differentiation protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007216">
        <property type="entry name" value="CNOT9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12262">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04078">
        <property type="entry name" value="Rcd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="358" mass="40865" checksum="51F8E9C9C783901F" modified="2014-11-26" version="1">MDAPAAYAPWEEESEDVAKFGYRQQRFPQAGYSRFPVTQAPQRPPQQLQPPQQQAVLPQQVARLEPSQYPDAVREMLMHIQSLYPQDTRERAILTLSKKREKFTLLGPTLWYSVGVMAIFLQEIVSMYPLLNTPSSAPVKPIINRVSSVLTLLQVIAQHDASRRPFMESNICLFLYPFLRATPSERSEVLRLTSLGVIGALVKADDPAITSYLLNTEIFPICLKIMEQAIEISKIISTFIIQKLLISDQGLAYACQNPSRFTAVADVLHRMVAEKGTQNEHVCGPRLLKHIIRCYLRLSENERAREALPKILPEELRNNTFQEYLDEDINMRKWLLQLLVNIGDEGARRINETAKHTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPZ8</accession>
    <name>A0A088RPZ8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Calcium/potassium channel (CAKC)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LPMP_204310</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698632.1">
        <property type="nucleotide sequence ID" value="XM_010700330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPZ8"/>
    <dbReference type="GeneID" id="22574642"/>
    <dbReference type="KEGG" id="lpan:LPMP_204310"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200049200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_204310"/>
    <dbReference type="eggNOG" id="KOG3193">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="257992at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000223">
        <property type="entry name" value="Ion channel/Calcium-activated BK potassium channel alpha subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003929">
        <property type="entry name" value="K_chnl_BK_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047871">
        <property type="entry name" value="K_chnl_Slo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048735">
        <property type="entry name" value="Slowpoke-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027:SF10">
        <property type="entry name" value="SLOWPOKE 2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03493">
        <property type="entry name" value="BK_channel_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21014">
        <property type="entry name" value="Slowpoke_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="13">
        <location>
            <begin position="261"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium-activated potassium channel BK alpha subunit" evidence="12">
        <location>
            <begin position="479"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Ca2+-activated K+ channel Slowpoke-like C-terminal" evidence="14">
        <location>
            <begin position="1044"/>
            <end position="1101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF21014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AIN97925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1110" mass="126842" checksum="8E6DFF78C670423C" modified="2014-11-26" version="1">MPLTADQAGSPLHYFSQVSLRKGNTEDAISGLDSVHPVDLTVSHRSRNQNLPPLKRYWRTRSVRRNHTQLNELGELENQLLPARSLSRLNTITNSGESDFTYISGPKYFFQQLVRQYPLAAFFVWTFLFLVELSMVVLYLIQSTMSYDVTWMHYDTQERSGWFYARTLLSVISLVQLFFAYSLSVMTITVVLITSIYQIIIFFVSIPSNLAWVSCLYVPYFMRCWPMRQYFLFILDSVALMMPRNRKLDLLRLAAGPLTLFICMVFSASGVFRIDQCFQGYPINMAVSIYFVVVTVSTVGFGDVTPQTQDGKAITIVIIFIFIAKMPTFIRVIRSTAKILKAYRSYTGRRNHFIVYGHLNREEAVSILDEVFCLYPMKSVCFCSKWFAPDVLSIGRHPTYRLRSTFLIVDTLDSFALRRMKAQDASAIIILPIREGYSSRVDDDVMLAAIIFERFVPKVPQYVWLRYGLHAKLLKGQRSCVIDEHIKKNIMASALLLPGIVPFLVNLVRSAWAEGVEPADLWTENGIEQWKSQYEYSRRNVLSTCLVPLRFVGATLGRVVANFKYRDVLIVGVEENERRVMRFDLNYRLKEQDVLMAVYERTRNSLSRALEEFSSPGPVNEAAGETYGANFCQGLNSEELLHANMNSSFVFYPYKSSASLCDMVPPQTPAISDGADTADKGDGHIDSKPEDEALSLEEVRRALMNIAGIVRAPRGIPLASLQLRRRTAAHLWHLTQRHRGLLVDLSMSVEDREEALRDVTDQINSSVLKAADMYLAAMSEQDRQAMELKRQDEVFLFIDQTSSILRKTATSVYEDVISQTIAQYELYVMMQCICAVHAHSRLTLLTLRRYPPHFFQTWKDTFGTPLRYIRGQGSLDSHLNYALTVDTDVTKVRGILLYCSQMGPRDFGDIPIFSVENSVLDLLEWNEQTRDGLSGAREQNIVVELQSFLFSIKVSPFHTDAVWRTRGESNFQDALAFMMGRFFASNMLITILIHSHRDSRIIKFFEMVLNLTSTANMFDKAVWANRSAQSQTLFKLCGNHSLRFQTFGDAFEFLLTKRQCVAIGVFRLFPASEMLSGMPRYFVTNPPMCMPLLMEDIIYCLDGSLRVACE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQG6</accession>
    <name>A0A088RQG6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mis-match repair protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_211080</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698895.1">
        <property type="nucleotide sequence ID" value="XM_010700593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQG6"/>
    <dbReference type="GeneID" id="22574930"/>
    <dbReference type="KEGG" id="lpan:LPMP_211080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210014800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_211080"/>
    <dbReference type="eggNOG" id="KOG0219">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0220">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276261at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.110:FF:000031">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF139">
        <property type="entry name" value="REPAIR PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="5">
        <location>
            <begin position="1000"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="457"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="594"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="766"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="813"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="607"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="772"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN98188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1146" mass="124778" checksum="E45DC2BB984097F7" modified="2014-11-26" version="1">MVASAATAQAEPCCVAALIFNNAKEVGVALCELPSLTVSLFQYGDTATFFKTASLLHTRNPVEVLVPSTTVDSELVQTLLRQHGAHMTFTSVQRCFYNAEEGVQRLSQLKSSAEASLCIEDTDRYLCVAAANAVVLYMEHVNDMHLLPGSVRVRAEALEHYMEVSRTTARALQIIPDAACMSAAAAAPLTFMGNAAGGNGRADRQQREQVQRYGAAPKLSFLGHDLPEPPPLLQPVALVDAIPRACTVMGQRYLRRTLLQPLRDRVAVQGRHDAVEWLLCEPRRLHILRTLLRHITTLDLERLTATLTHQPRRERTGAQQQSYLESLQLLWSALPYLEQLHIQLKAYLGPLPRMPEPVHQEGVPSSMRSTLPGGEPDVAASPNDLCSTAAHPSVLHSIATALGQCRLPELATLMSTYLERSVLPSVVDHHEKSAAHYGALHGFDPGGVHIPPDVSVVAQQQHSQRKRRRLCNDDDATNSHHHRQQPSQRPTAVLLRLLRMCFLVQAPRGGELDALRTRLSLRISDITSYAVELRATYQIFSLRLEPDPVKLYCFSYMAAEEAKAQSGPFTWRYAGGSHFALYLSALREQQLQRQQVRQQEEGRHLRSSQWHLATSTEDSLRTASSFPPPELPRHTISADGAVPNSSAVDLFPSFTSDTDPTVSRQLRRRRVRCSTEDLEYRCARAQECVAEILQLQLHDVQPLVRAIQNEFLGSLQATVESVALLDTLLCFALYSLTHQCTRPVLVELRTGSTTAPRVPTVTAELSGDGEMATSSGRRATAAAGGAQVSRDKLDEYAGDASAASCVGDQGGGTVASAGMSETSSDPATPPSTAPLSSLTAYTMASSAMATVTESRYASRAFLRIENALHPSATQRQPPSRAVTRAGVSARLTGVEAVGVVSSTSGSSGGLTISWGSHGGGVCVVTGPNACGKTTLLRIIGQYFTLAQAGCFVPAQHAQLFLADRLLAHMLCDELPSIAHSSFWRELMELSELTHAATAESVALLDELGRSTTTAQGFSLAWATALLLSDRRVHSVLTTHYAGLPSLARVRPTRIVAFHFRVAFEQLVARDGGRDGAAASSSREPARTRITIARFGHTLFPGPCPQRWYGLALAERLHFFEPVLAMARHTRACRSPAREAYTEEGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RR06</accession>
    <name>A0A088RR06_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mitotic sister chromatid cohesion protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_220150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699017.1">
        <property type="nucleotide sequence ID" value="XM_010700715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RR06"/>
    <dbReference type="GeneID" id="22575061"/>
    <dbReference type="KEGG" id="lpan:LPMP_220150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220006700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_220150"/>
    <dbReference type="eggNOG" id="ENOG502S0ZG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276989at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034088">
        <property type="term" value="P:maintenance of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019128">
        <property type="entry name" value="Dcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13395:SF6">
        <property type="entry name" value="SISTER CHROMATID COHESION PROTEIN DCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13395">
        <property type="entry name" value="SISTER CHROMATID COHESION PROTEIN DCC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09724">
        <property type="entry name" value="Dcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="476" mass="52251" checksum="CA234434DE1ABCBC" modified="2014-11-26" version="1">MDHILVRSDFACRREYRLVSVDEAWVKQLQEQVYPIHSAKKGMARHKRARASSPPSATAHCDNVSVAFVMKGDGQLCLHDAQSTRSVRRVEYSNTMLLATRRLNRIGRSASGESPCRSGDVCSADGMATTTTALPFPEANVRQYTNDVVVAALSRMFDSHAVHPQDNVCAALGESYLTIEELEGTDGSSHCSRTAGTPGRGYTFAQLARVFRSSPSELADLLQSLGAVVHRGLVRLLHPSLVHESLTAVLTFFDAAEPCDVSWPAVREHLCPSVYPDVVLRSLEAVYGVPRVASETTKHEDSVARLGMPAVLNLQRVLVGLAGGVFDAHQDVVCRTLGTGEVARGLPLETFAEAWMDAIPSPLFSVAGITHRGATGMQKTLMEKLHGYVVVESRSSGVGGTAQDTAWWLPKETLSNDFAARLRALFELRPQLWDQVELKEYLCMLVPPEQSFEHVIARYTREYRIPGRPVQYAPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RR12</accession>
    <name>A0A088RR12_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_230970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699254.1">
        <property type="nucleotide sequence ID" value="XM_010700952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RR12"/>
    <dbReference type="GeneID" id="22575302"/>
    <dbReference type="KEGG" id="lpan:LPMP_230970"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230016300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_230970"/>
    <dbReference type="eggNOG" id="KOG2084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="20"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="466" mass="49809" checksum="20B3C23816E5988D" modified="2014-11-26" version="1">MDPSVKAASELNAIFDRLGVLCEVCVTSAEGKHVKATESLKEGFALVEELPIVSWPSPSLLTLSTPFCFQCLRLSSHQPSTAMSDSELLPSTSCSSLTSAVGAARVPQSWSRCAHCASYFCSSECQQASSRVHRLLCSSLPVVREGHGGSGGRSGAEDVMVTAPGSFSSATTSLTSSPTSSEITLEALARCVAWIAHRLSYAIEQQQITHEMLQADYVFQQQQQQQAGGSATGAVWSTVSLNYQLFTQVVTPFSRLVSPPNNVEFDSAPLSSWMAKLRVLLAERCVEELLIASGTSLSAVERHTLAFNEHQAVPAPALLWAEALVQVLLSFDTLRTLVGQMVLNAHAINDYVLLPVGAPSPSAFDWVLKGAGLYSLLACFNHSCVPNAAVSNVDGTHEIVLKTTRPIQAGEPLTITYIPLSAGAMSRAERQRQLRNYFFTCHCPRCTKEAGAAGDIAAVTGSSNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRH6</accession>
    <name>A0A088RRH6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_203290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698531.1">
        <property type="nucleotide sequence ID" value="XM_010700229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRH6"/>
    <dbReference type="GeneID" id="22574540"/>
    <dbReference type="KEGG" id="lpan:LPMP_203290"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200039300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_203290"/>
    <dbReference type="eggNOG" id="ENOG502S07D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272387at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="878" mass="94552" checksum="D194606E6CD692C9" modified="2014-11-26" version="1">MTSEDESSWRLLFGIALSHGELLRAGRLSYDGWIVFLSSAQLIGTAVGVFRVLLDQLWGQQCLREDAQQANADEREPGAASVSSRAFSLGIGSLCTSLTPQSSHRSGRASAAPSISSPQLSSAAHEGESVGFSSFVDMIKVICVRIFQTQRYTRLREGHGKCDEGGRESALLALRQSAEDHVLLTESVKYTADAFLRPFISQCVIHASSQVRLCPAKNGWAPHVNRLVTHIVGALLHTAILPLFRKYAVTGRLSEAGYRAFLRDTLPRLDAVKETCAVAIFRHGGFPDIRPLVASLEPLAASLSPELDTVVSEPTLGFTDFIEAMLMLAVVVYADEVHYPTQRPITAKVWSFFEEHVCGHMLYAAAMCPDPYITGRYVTVPPGLISVYPAVAPLQQCPCLFVEVINVQGNSVVEDTVPLSTGQAYSEDSQSAMFLTEMTAAAKAELPLCSPGECGANSDVAVLAASTFFMTEWSLLERNQRVPLFGCSQVPVSHAIMICGAAAEATPTSCPEILRVPLPDSLQQPMLYRCAVEAVAATASSGTDDDGTVSILFTPFRSLTVEMAVSDDSMATRGEGSESAAQSRPWGCADVVVTDIPLVQVVPSHLVAQLHNLFLSQTLAPSSDGPAASAPPCISLSAVCELCRQLQWCAASARQQHDLPSLCAQAWASYCDFQRLLRAAVTRHGSSSAAGRAPSMYAGAMSSFTGQAVLLSFTDFAGCLATMLFQMQGGRLSDVPDVPRRLELALSSGSSTFTLGIGSSSFVADAGLRAPHIRSIPYNAFRDVPFFMALERKKKRSEAAQERCTALIASLREYHALQILSSVTLPPLPEDRPSAMRLVSQYGTVSLTEVFHAVMREGAEVVKAHFVQQELAIPEMTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRJ7</accession>
    <name>A0A088RRJ7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_231490</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699305.1">
        <property type="nucleotide sequence ID" value="XM_010701003.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22575354"/>
    <dbReference type="KEGG" id="lpan:LPMP_231490"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230022900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_231490"/>
    <dbReference type="eggNOG" id="KOG0968">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2414538at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05534">
        <property type="entry name" value="POLBc_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030559">
        <property type="entry name" value="PolZ_Rev3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812:SF1">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="7">
        <location>
            <begin position="2119"/>
            <end position="2578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="233"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="373"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="568"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="625"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="694"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="820"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="945"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1033"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1127"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1203"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="373"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="390"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="633"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="654"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="694"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="946"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1248"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1280"/>
            <end position="1306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN98598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2979" mass="318835" checksum="3B83BB5264EA9AB8" modified="2014-11-26" version="1">MCTWDAAGHHNRDATTGAVAQHCDTPSSSSLPSCTLHAATSARGDEGHPLNYTAGSLRRSTPWCNRYSQRRACLHVHGVYPSLLLPQYDRNVSAEQLAAQLEAVALRIFARQGTFVPGQQLVHNIRIVRRFSVYGYRPHAHAFYEVELIDPDLLPRVVGVLQNSTEVGGRQWQLYDAHHEYRMQFMVRWRVNGVAPFLLPVERCHVRLPTVLELSENPSILSASLYTAGGLQAPRRRCSDDSDAAERELREKDEEERKDSGVMSAQRSQLPFRRRWRPDELDRFTTAEVELDVAGADLLDHSSALEEEVADGAAAAAVKGRRRTVTADDNLSYTRRIIRHYFREHGMPDALRVADTIVMEHHQRECAHLTAAVSRQRTSPLTTTAAAVPESKEGEERQQRHCSSVMQLQRGDPTVRWLRQRMLAYLAERAELNSEVTAALVASSSPKTENGGEASTSMHLAKTNATATWTLPLSSTAFRVGSAAKLQEQPAIRQSLLAEYRQPGGATTVPSRQGYRRGATDAVTTHAYTDAHIVVRSSCTHVPNPAAAVAGGDALYVGFSPESLQLSVSQEHARLQQPQPAAAPGNAVAQSVPSSSHFSFDKISPTTYADVVAAPTQDLLMALAQPSTPPVPSQTSATTTSVAAAATTTQRGGSLKEEEASEVGCRDMRSAQERNREVVSNADVTLTCAASAAPTAATSPPAGSSWSSASSLSSTVSSSSGRASLDDDSGWVGHCGGVGPSFLRSSAAQPHQRAQEKPRSAAFVPAAVVSDAPAQRLLRSSVCPSPRANNCQHDDLAFDALDSVDTEVIRRSVAASQEDGSLLPLESDASNTASDELASTKDSLTPEGQRRCAGVAATASLVVTQSPHLLPTHHGFVVGDCVAFVCVRDVASLCHLGEVLAVGRVAALATEMAELQWLLRLSETHLAAEEHALVRRGSWLRAQRPSATATASTASSMRDHHSHTAGVAHHVQLGEMVLGDVRDSVPISILGGDARAALTYAAAPSASTQRLPAGEAAASAACVLGVNTVGLTAHETGPEERSVSRQPRPRRPLDDAAAEVQVWRAHCFTTVAAYQSAAGPPHGGHWPHADYPSCSSRPLLRVLCRYAYHAEARVLTGVSTDVFTSGAQMSAVDKRPRPPSRRISLRGGKQLESGERTTDTTPVHRSSYVRASLSRVCFSQPQLLLSSGSPLAHSKAAVASLTSAQVPSSPSVEPPATFAMAPRRESSEDGGEDTLLFPSSSASAGSSRGDHRDAPKRREVVTPPCATRSALLDLTPMSGEAPLQSPSEASSALPSPSASAQPPQHAADAESAPVIERPWRVSLARTPPPDFAVGSIRVQRSVQAAHRLANHTFISEKQARWRRRGARWTSDRNNGGAVTDTAAAGATKETAAATQLTFSNVIADADGDGDGEQPLGATVSIDSAVADADGGDTVAGVGGRGTTEVVVASAASSCVRSSSAAPLGSLITSSLTFSQLSSSSVEAVREVTTSQRGFLDFLQARRHLDEGAVRTALLQHRGHLDCIVDGMTRCFAVTTCGRYGSFRSRWSGSDDSRVRVSAVTWPWTASTEVTPKDGALAPPRYETVASFPAPPASITGVARSAKAASATLRAASADHGPTHLNRSLVSRRTSVNHVPAMSLSATQQPQHYLQCTLRALYVEVLLHRRPGEALVSTSEALAVGLGQATTATNSAIAVRVLCVKAAMRNSGVSAAHPAAASSAWGSLPSTAGSTPALVGLTGAVQVVTVPDEVALLARVRDEILTYDPDILISWDGFKYGLGHLALRYRAVLQRNLASDLSRVLRHHSYHQLNADGVWRPAAAASASGGNGGADSGVAEPVYPSMSEEGLAEICRGAAEAGEVAAAKCRPLPPASDAASLFAIGDDSSGGSVYAQQPLQNAISMAAHSSTLPSAAASASSAALLNDLDEDGESMDDGGADDAGAKGGVCGRRDSVLVRQTAELSGRRVIHWAHTDLQRNGQSPLLARPRAEVDLGAAASTSTLLAPAAAAADKYAKRFGASMHVVGRICMSLGKDLRKYIKMPSYSLPMVHAELLGQPLPYFTDSYLSELFLTPQCTDAPVGGERHTALRYLASRVAALHRIACKLHWFTKLLEFSRMYGVLTKEVISRGSQFRVEATFLRLAQPLGYAMLSPSLSQVHCQPRIECIPLVMQPKSDLYRHDPVVVLDFRSLYPSVIIAYNLCYSTCLGMVQPQSHGRLGVLPRFKQSDATLAELLSDDGAQHDGVVFTLNGAMFVSPSTRVGLLPQMMKAVLDARFEVQAALKHIAAPLEDMAMQQRLQEQQLALKMLANVTYGYTAASYTGRMPCVDLAEAIVSLGRQTLERAIALIHSTPAWRAEVVYGDTDSLFVRLSGRTKTDAFRIGQEIADAVTQSNPTPIRLQLEKVLLPCLLLVKKRYAGYMWSSPTQAAPTFLAKGIETVRRDQCPATALLVERLLRLLFDGASATALRRSYYAAVERLQSGAANPIQCIFRRGVRLGRYRDSGDAHLPLAARLALEQMEKDVTQTPYWGERLPYVVVRSTTAKKLADKVLHPERLLQIDDTHSLDATYYIVRHINSALDRLFYLVGISFAEWYGAMPRRRTAHAALLSLPIFMAAQQRQQQLQGVMSPDGCAAAPFLFSSATPSTALIPQSQQVRLEKLESLMKELHHPHGSTGLLSSLVGGGVSAAATTAAAAEVISDGDDQSGEVVQLSEVEDLTRSSIQEVIDVDQLATQRSCRPSSSLTDAVSPPLELFLKPGQAASRSGRRHQWRTVTLDSFYPRTLCVVCEKEAVSLADISRQQAVLMHVGVGGFDAAASGRLCPAFPCASATAAPPAPLPPPLLFPPICTRCWSEPLSLYLRVQQQCRSISQQMNALQGLCARCISSGGDAGDTAADEYKLAIADMEDMDDFCMSALMRRRAFPRHAYEGVDGSTPRHVLAAVELSAEGVPRGCVSVDCAIGFEKKWVAAQQTQWQSLQLFLKMAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RS41</accession>
    <name>A0A088RS41_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_250950</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699664.1">
        <property type="nucleotide sequence ID" value="XM_010701362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RS41"/>
    <dbReference type="GeneID" id="22575743"/>
    <dbReference type="KEGG" id="lpan:LPMP_250950"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250015500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_250950"/>
    <dbReference type="eggNOG" id="ENOG502S5AQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10057496at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24124">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24124:SF14">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_25, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN98957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="260" mass="27826" checksum="887747E3A604452C" modified="2014-11-26" version="1">MLLAPSLQVMDLVHMVIQGNLSALMEDVTPSNVNYTDPQYRLSLLMWAVTLNRLPTAQMLLSRGASLALVDRHGFTVLHRAVWNADVPIIHMVLFITPMSAVASSSDAGATGTHPFTTSSQSASSSLLTWRPGAQRLVNAVHPATGRTPLMLAALSGCVDVVRFLLVTCAADPYPRDSYGLTAVDLAALCGHLHVVQQLLNLTVAPNGAGDSAADVFPTTQCRAEDYIEVAKTIPQRQRLCAVNKLLNESLTEASRVAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSH6</accession>
    <name>A0A088RSH6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_252190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699789.1">
        <property type="nucleotide sequence ID" value="XM_010701487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSH6"/>
    <dbReference type="GeneID" id="22575867"/>
    <dbReference type="KEGG" id="lpan:LPMP_252190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250024100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_252190"/>
    <dbReference type="eggNOG" id="KOG4648">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="41"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="213"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN99082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="334" mass="36527" checksum="7E3A37F57D244ECF" modified="2014-11-26" version="1">MSEEVAFKRAGALFIAGKYPEAISAYTAIETVNEATVEVRARALNNISACYAALKNYEMSSKVAREVIVLQPNNAKAHGRIAAAEEGLKRYDEAAFYYSAASRLEANNPVYVAGAQRCHALVQASRGVASAEAKDAYYYKKSLERAMKAMQEANYLEAIRHFGKALDLFPTTGASREKAALLCNRSAAYFRAERIEESADDALEAIKADDKYARGFYRLGAAKTKLKKVGDAYDALTTCLKLDPNNADAGKLLAEVLPAALESRKTAEERARDHTRQVTHIAEQLNAMQATASANTAPQATAHGSAYSYCNFCNETGHSRSECSLLRRKRSRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSP7</accession>
    <name>A0A088RSP7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arginine N-methyltransferase, type II, putative</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">PRMT5</name>
        <name evidence="5" type="ORF">LPMP_211660</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698951.1">
        <property type="nucleotide sequence ID" value="XM_010700649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSP7"/>
    <dbReference type="GeneID" id="22574988"/>
    <dbReference type="KEGG" id="lpan:LPMP_211660"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000006100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_211660"/>
    <dbReference type="eggNOG" id="KOG0822">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1368803at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000038">
        <property type="entry name" value="Arginine N-methyltransferase, type II, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000494">
        <property type="entry name" value="Arginine N-methyltransferase, type II, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035075">
        <property type="entry name" value="PRMT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035248">
        <property type="entry name" value="PRMT5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738:SF0">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05185">
        <property type="entry name" value="PRMT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17286">
        <property type="entry name" value="PRMT5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRMT5 arginine-N-methyltransferase" evidence="3">
        <location>
            <begin position="563"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 oligomerisation" evidence="4">
        <location>
            <begin position="785"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="413"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="460"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN98244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1013" mass="112108" checksum="DDC68679DF1D14F7" modified="2014-11-26" version="1">MSVDGGGISNDPDKQTTVSAMEENYCLHGREQFQNQWARTGVFSPASLRVYGVTGEPVLMRSIKQVRMLGATFGTCFLGRFPQSKLPLSLEDNGTTAVTQRGGLYDSLPFSSLLLGPCPPSNMMADPRMLDQAWSREVAGTWSALHMPSEWCQTMNGVVTEISWSTRAQRQRIAEQLELAAFMCLRAVQVPLPFYATDTPWSCDDDSSDEKDKDGGTTMGTRGSTQTISAEEANQRNVRAACLAADVVLSFIQQCPRVKVWVRCDACNPAHRYQLQRLRQAVLYGYSTHRKDTEQLMYRINTPCSVTNMATNSMSDALPSSSSPCCRVVHTEAAASLMALLYYSTWNPRMLLPSEWFGEDVVGFECPTASALLACLAPHGVAPQEHPHYRPSTTLAEKDAEEAQEYEYQNNAYHDKDGAPLQRTPPACLDGESEASQADYSLGDGYDSVTEHEASHPADSGAVAANGSPGSAPASFSEKAADCRRSEVLQHRYTYVMPEDLQPTVASRWAGTYPPFVSALTFIVELLRRRVMPVFDRTFFDQYALLNYLHFKAVEEPTRDVFASFEGQLQLPLQPLSQHLSSGVYEVFERDARKYRQYREAVFHYVRDWYAAGVEQQHAQQNSEFFAKHGVMKRVPVTSADERTLHLVLLGCGRGPLIDECLNAVSALGVRLRIFAIEKNLPAASFTRMRWANDPEWTQLAYTFGHTLEVIVADGRAIATAEENNSLTLPADFGLCDLIVSELLGSLGDNELSPECLEAFHAQLKDIQHRRGIAFNPYLTCIPQQYTAWVAPLMSASFDAAVMEAATRGLTVPPPGCSDHHAALHHTLLVTNLSRAVTLAPPQPCWTFEHRFSSSYDDKRDYGTMKQQVPVLLERSASLLFEVPPRGRCSGLAGYFSAVLYQSATAPATIIATTPAQRTEDMYSWFPCVFALEPAQQMELHEVGQSSAEQKPMVAVRVQLDRRASPAERKVWYEWSVIYGDVAAAQKSPSAGHGAAAAPVVHNKNGWAASMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSS4</accession>
    <name>A0A088RSS4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_260280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699849.1">
        <property type="nucleotide sequence ID" value="XM_010701547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSS4"/>
    <dbReference type="GeneID" id="22575931"/>
    <dbReference type="KEGG" id="lpan:LPMP_260280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260007600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_260280"/>
    <dbReference type="eggNOG" id="ENOG502S4EH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="238669at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="198" mass="22230" checksum="2DDD8314D5F54302" modified="2014-11-26" version="1">MGQRQSFESKLQMCVCNHNVEQMKELIQDPEFVAENMSDTIFVDLVERQWDPSTTMAFAKKANDHQLAILVSTAIIHSSVLPLSTLFHLMRDAPDTIRKEHLDELFMTACDHIDTEAVKALLAAKCFDSGDGRPIVTVVRRELSKRAPDEELVQLVLDSLPGHEDLATYLLETCVPTAKNEATKAMLTAKLKSYLKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSW7</accession>
    <name>A0A088RSW7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein transport protein Sec24C, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_251370</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699707.1">
        <property type="nucleotide sequence ID" value="XM_010701405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSW7"/>
    <dbReference type="GeneID" id="22575785"/>
    <dbReference type="KEGG" id="lpan:LPMP_251370"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250019400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_251370"/>
    <dbReference type="eggNOG" id="KOG1984">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000073">
        <property type="entry name" value="Protein transport protein Sec24C, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000133">
        <property type="entry name" value="Protein transport protein Sec24C, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF4">
        <property type="entry name" value="SECRETORY 24CD, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="5">
        <location>
            <begin position="323"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="6">
        <location>
            <begin position="407"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="8">
        <location>
            <begin position="648"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="7">
        <location>
            <begin position="743"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="100"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="147"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN99000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1020" mass="111452" checksum="DE28B67C0B8BC947" modified="2014-11-26" version="1">MYNLPVQPSNPYEGGYGSYGAYGSAAASGGAPAAGSYYNPNQGYTAQASYYGGAAQQGAVPPQQASSASPSSYNYGSYGYVSAAAPSATAAPTSGYPYGGSGGRATTSAQASPVSAPPIHASASPPSTSAPSATGCSPYGYQAVAATPAPSQPPAPSAPSSVYPSSGNVSSTAVTASDPYPVPSSARPEPLTRQPIQQCGDAMLGSGSRDVSRPLRPLARQPPARVVNVRAVPNPERSIQRNSGAPVEYLTCTNEPPYATVNFVGLDNGNANSKFFRPSMLCAPGEERLVKDSHVPFGAILAPLCQPLHNKEVVPLVKQPKPPVRCHRCRGYMSCHAQVLEMGRKWECPLCEVTNDVADDLPITDGMGGRVSVADHPELSFGSVEFDVDDFPEYALRTETGVVLPNRPLHHLFLIDISRDAGQRFLADYAEAIRAALQRMAELTPECRVSFITFASQLHFYNFRHPDIPQLCVPDIENPFAPLPFTSLCWLEVGTELERLENFLTRLPRLAVDADESDCVLGAAVKAATLVLAGQHGGRVIMCAGRHPQRGIGHIVLREQHKLYGTDREKELLRPIEGFWTTTAAVAARQQISFDLFMFATGYCELVTLSNVCHVTNGRVLLFNNYDPLVDNTKVSASMQQLLTEEAGYAGILRVRCSTGLHVQRYRGHYLSQTVQDMDLASITGSSTFFVEFAHEDNLPKDNYAHYQTALLYTTRSGHRRVRVQSCRLRVASSLTVLFRNMDLEAVLFGFIQDTMAEAVNKGPRQARQGMTDRLIKAFLCYRQYCASEKAGGDYEDVKTTIRDKKNTLLMPPRLKLLPVYLLCLMKSDALTEGTIVHIDHRVASIFDLVAMPAHKLLNYLYPSLFCLDDLESDPAIGTLDVATGDCILPHHRQLLFDSVARDGTYLLCDEQARLVYMWIGENVPPKVASTLFGTPDVGSVCVVGGPGEECFSERLRNVLYALMLRDDGMRRLIVIHHGERSEDSFFKELKEEMCTNKMGYDEYLTHLHRTIQTRVSSGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTA4</accession>
    <name>A0A088RTA4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_270010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700089.1">
        <property type="nucleotide sequence ID" value="XM_010701787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTA4"/>
    <dbReference type="GeneID" id="22576177"/>
    <dbReference type="KEGG" id="lpan:LPMP_270010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270005000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_270010"/>
    <dbReference type="eggNOG" id="ENOG502RX85">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276709at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="374" mass="42646" checksum="BD3863160F141104" modified="2014-11-26" version="1">MESKTPLFLYFMVPNHPEVKQYTNLLCHQVDQANRRLKGDNFGELYQEFGKDAGLAIKLGMVDCLQEPGLMAKFHIDPRMFPFIYFVRNKVFCDKLVGIVSESHIKEAVEAFIDYAKQESKNESEGRSLFQQVKRQDNDEENAMTLIAAAHSKMQAGEPAKGKQLFEKALRMSLEDIEIVKQRYGVPHKKMTPELWAKLKREPCYNSAPEALCGLAMCAMASKQRDEAFRLAAQVREEFPFAPQDMRSVAEAVVRIELIQLVDYDPDTDNYMRLLKFDELVNEPAQFYRHHLKRAVAFYVEGVAGQAIEECLRLIRAEPKLLAALKENGIVPKDLRLGPVAVTPARQVLQGIFEALGPTNEHVQKGRKLLQLYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTD5</accession>
    <name>A0A088RTD5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_270360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700124.1">
        <property type="nucleotide sequence ID" value="XM_010701822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTD5"/>
    <dbReference type="GeneID" id="22576212"/>
    <dbReference type="KEGG" id="lpan:LPMP_270360"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270010100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_270360"/>
    <dbReference type="eggNOG" id="ENOG502S76E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268604at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="194" mass="21853" checksum="5D3DBFF45B038BFC" modified="2014-11-26" version="1">MNVEVTDRCFFMGDDYYISLPIVNKAANRGEPLQLLCSEMIHWDDYRNDRSINDGKPRMQQLFASSYTEPLARTFVLGSDTYVTQVTGVSATQAGSSSQMFSAEMQHWDDYCATRGITTGSPSMASLFRPFESKIILAFDLNERKLTELEGKSVALISYGAKQQTYCSEMEHRDDYVREKTGKAPEPSMASLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTQ3</accession>
    <name>A0A088RTQ3_LEIPA</name>
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        <recommendedName>
            <fullName evidence="11">Zinc finger protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_270130</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700100.1">
        <property type="nucleotide sequence ID" value="XM_010701798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTQ3"/>
    <dbReference type="GeneID" id="22576189"/>
    <dbReference type="KEGG" id="lpan:LPMP_270130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270006800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_270130"/>
    <dbReference type="eggNOG" id="ENOG502S667">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2020426at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035329">
        <property type="term" value="P:hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051252">
        <property type="term" value="P:regulation of RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000035">
        <property type="entry name" value="Salvador homolog 1 (Drosophila)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000003">
        <property type="entry name" value="Zinc finger CCCH domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030030">
        <property type="entry name" value="Sav"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47522:SF2">
        <property type="entry name" value="PROTEIN SALVADOR HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47522">
        <property type="entry name" value="SALVADOR FAMILY WW DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="WW" evidence="7">
        <location>
            <begin position="10"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN99393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="12981" checksum="B40A47E6D1223D64" modified="2014-11-26" version="1">MQQAYFGQQPMLPPGWQLSYTADGKPYYIDHNTKTTHWTIPPTAYESYYNNGRGRGVGYRGGRQGIDRTKMKSKMCIYWEKNGNCAWGDRCAFAHGAEELRNPASQPRSNAPASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RU12</accession>
    <name>A0A088RU12_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_240860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699426.1">
        <property type="nucleotide sequence ID" value="XM_010701124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RU12"/>
    <dbReference type="GeneID" id="22575495"/>
    <dbReference type="KEGG" id="lpan:LPMP_240860"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240014600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_240860"/>
    <dbReference type="eggNOG" id="ENOG502S78N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="247796at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="117" mass="13188" checksum="56B9D71BEB65B896" modified="2014-11-26" version="1">MNGWLVVLALVGCLSTLYFAIGIGVRYHSGLHHCPEVLPNYRFWCNILNFFLRAATCGHCHVSFDHNNRSSGIFVLPSRPGVSVSSRRVQFELLSSDADDDYDINRVMQPAEVVVKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RU44</accession>
    <name>A0A088RU44_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_241360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RU44"/>
    <dbReference type="GeneID" id="22575545"/>
    <dbReference type="KEGG" id="lpan:LPMP_241360"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000035700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_241360"/>
    <dbReference type="eggNOG" id="ENOG502S33W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277887at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="200" mass="23119" checksum="2395B70EE4C686F4" modified="2014-11-26" version="1">MSEVTAFSTYQTRSTLLVERERALDARRAGVSDLRQMVAMLTTENRAREEQLAAERSRFRDRKAAQDAKVSTKETEARTQQNRISVLEEEERQLNKTIAERAEEIRTATAEVERRRDLERTLHDAREGLNKAKFALEENDAKVMRLETRLARQELITDKRHAQLTGRVPQYWFPRVPEVDKSASLEDTAGESVYLVDELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RU60</accession>
    <name>A0A088RU60_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_271840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700270.1">
        <property type="nucleotide sequence ID" value="XM_010701968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RU60"/>
    <dbReference type="GeneID" id="22576362"/>
    <dbReference type="KEGG" id="lpan:LPMP_271840"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270026600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_271840"/>
    <dbReference type="eggNOG" id="ENOG502SJVZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267912at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="682"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="754"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="803"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="849"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="562"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="803"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="878"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="920" mass="97676" checksum="A944166DFD9318CB" modified="2014-11-26" version="1">MGMSGRSNAAPSEAVFPRRVTLSPHCRQPAHRHARPSPACTPHPSYEQLTFDAAHHGTPLPFGDAFCCWVDNGGDKTEPHRSRPKPTLHASPGGFSSSHLRQHHHHHDPFIHYSTSAPFMKCGATSSMSASPTPDANAAHMRRVKHRPYSRTHYPRSAASASAQQLWPSEAQARWLRSQRGDASSAVVEEKAPNAHLARPRCDRQLSPLSSQLLDSPTRAAIPTFDIMRLDASPSRSRSSRRAASRVRRLLCALEAEAQRAGCTATDAASAQGGTAELYQSLFLQALADGAAWERHARALEASVQVSAKREVRLTRQLRHARRTVALLAAYVEGAERVVDVLSRGTASGTVASTQTDRTVPSRTPPTSPSALIQSAPVGATVDMASASPWRPTSRSAVSELIQGSLGCSLNLVYGTSGSSSRYGEDEDEVDDAESVTFAASDATVPRIDEGLRTAAVKRPGDWCELHGLHSESLTSAPKVVETRWDQPSWDGHVDDVGTGVHARYEMAMAWECEDRGNSVQRLHRGGTEELETPTAWSRELPAAVRASGVARRESASSFPHAGTTAPAAAAVEDSPGHPANSLSPSSPSVGRAVAINTAMRTESVTPKSAPLDAVAVVAAAPQVAPTSVVHSLLELLRSRDTATQATATLGHGRVATSPETDSNTTAQIAAAHHLAHYQATVAEATQSHSSGEAAHPRRVMPAMASSSSSSASRQPLLAPSCSPILRQSSEPKAEGNTLHAASLPSLASSLLPQSHSHALAPQPPQLPRGGDSGCSNCGPLAKEAAAVGTAPVKVTELIHTPSPASFSFSPRQTSTHLTDTHQHDGSVTTHSDNEPVYLSSDWESLETASLADDSGKRSSSSPKRQLEEARDGHHRAASSNNINGENITDERANLADNDGYAEWRAQLEAHLNCGWVSGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUJ2</accession>
    <name>A0A088RUJ2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_250810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699651.1">
        <property type="nucleotide sequence ID" value="XM_010701349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUJ2"/>
    <dbReference type="GeneID" id="22575729"/>
    <dbReference type="KEGG" id="lpan:LPMP_250810"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250014100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_250810"/>
    <dbReference type="eggNOG" id="ENOG502SI8Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="263306at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="547"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="579"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="638"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="873"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="974"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="669"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1011"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1041"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1049" mass="113501" checksum="A6EEF4F4D3A2AC18" modified="2014-11-26" version="1">MEWRSNVSAATDAVWPLGTPSPSFTRSIASPPATPVTENLSNPPAVASQLPSPRSTGSWSDKGDLFANGSTTGYICAACHRVLEPVQALLTQFNAGKLHVGASVVDLAVQHPLPYLRVELVRLLLTFRRWNWSMCAPVAVAASVGDVDVLASLLSVEELEPNLGFPLRVAVQCHRNDQVLPFLVSHHRINPNYGGAFYVAVVIGNTEAMHILGAAAQVNVNRFANGEGTSALLYALRQLLVCSAIVAAAQQPSSTTSSAPRHSRKPQRGITSSSSPLPSTAEKMVTASPLFAGKVGDGVNAHAKHQPLRLLSGNADSSGVTFSAGATASGGTPFPSVSSNMIGPLWQRDRPHFRNVSPVVTMDDEHDDITLPAHGEDKDETHSIALQQDTVAHPLLTAQHWWAVLLYLLDHPAIEVNIGFYITPLQMAVFAGNVEVVSLLLQHPHLRPNCLPKPASVLCASYSLLQRQTLSKDALRCVVATPVEMAVQLHQLEIFKLLVRDPRVRLPMQLTMNLERLAWDAEAIPYLTILAQHRVDWEGWGWRWRRLCVLIATAANCVIALCSWAVWCAWYDSLRPCGVGLLCMYGVQVIMGVFLVAWEAYVTQTASSAVQQPAPVLVAFVQYLVPPWPSAWQCGFSAVLLLCPGMVPLLDLLCAWILYKTHRDRRPLQTAAHPGGAEPEVPPQHRPADLADSSTNCARLPNVSRERIDGAWRQSVWLPTPHEWPGMSVVSSVSGHDSFKGVPCLASFSYKESFSRLRTAMARTRQQVVTDSGDQRRLHAVGGAPASATAESAVPTSAHPMTTSTVGHASVLDGEFASHRTSSIMTNSIIASSPVGHRNSWVVPGRPSRFAAPTEYHTPDLTLRALAYVTYDWLLVTPRLLLSAVAILMFLYMLFPSSLSTLPSPSTIMVRKTTTAKADEAIPPPFTTAARDGTTTHSISALHYYDRLLSATLTEAAAIAVETNPADLAHLTTMMILVGLCGLVASIVSGTVLLAMMTSLRTITTKSCFANSGDRNNAGGRSGRNGYILRHGKRNTPRRAVAKSTDSMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVH3</accession>
    <name>A0A088RVH3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Prefoldin subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_261360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699956.1">
        <property type="nucleotide sequence ID" value="XM_010701654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVH3"/>
    <dbReference type="GeneID" id="22576039"/>
    <dbReference type="KEGG" id="lpan:LPMP_261360"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260018600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_261360"/>
    <dbReference type="eggNOG" id="KOG3313">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23156">
        <property type="entry name" value="Prefoldin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000014">
        <property type="entry name" value="Prefoldin subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016655">
        <property type="entry name" value="PFD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016396">
        <property type="entry name" value="Prefoldin_subunit_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR016396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN99249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="194" mass="22258" checksum="FE9096B24A7491B3" modified="2014-11-26" version="1">MSAITEKYTFKDDYVSPRGIPKVAFVENVAELVKSSGDSAETLLKRFSEQYSKYKLAEHRLIRTMANLEAKIPDIKKTLQTLAFLKKSLVEENGGKGFTTNYGLTESIFCQAKVLPQKTVHLWLGANVMVEYTYEEAMQLLERNLQSATENLATTQEDLAWLQEQQTILEVNTSRLYNYDVVERRKKSEEEAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVK2</accession>
    <name>A0A088RVK2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chaperone protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_291900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700795.1">
        <property type="nucleotide sequence ID" value="XM_010702493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVK2"/>
    <dbReference type="GeneID" id="22576953"/>
    <dbReference type="KEGG" id="lpan:LPMP_291900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000008800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_291900"/>
    <dbReference type="eggNOG" id="ENOG502S6SX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="14"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="411" mass="46583" checksum="860EF1D60E6B903C" modified="2014-11-26" version="1">MLARGCVLRRHSLSARRVLGLQDGQSYTPADIKKAFRERALTAHPDAGGHADSFRQLQDAYEVLLHEYRVGKKDSETATASEDSRSSSGFYAHPHAQWSNDMRSHRAYWHGMHNEMNMNASSCGSYRDASSTHYRAHPHHHAYGEGLGEEFQTHFKSSFGGHGQRGSQTNFSTWYFYRPYESDYRSPYGTGFTPEEIHQATQEQRRAFAWAVMRHTCLWSGLAFVVYLHERNNRVWRATEARGKNYQDPEYWAQVRKEEEEAQQKKWASLRLEHHWLDAPLVRPLMMDHTEDDHNGGGENVQGSKDNLSGATKVGTAMATHQARMTEKQRRQAGGPTRGMLRGVGGNVGGPRVVSYQGRPFTPNGVRGKRNTAPKTPKTYADDVTYEMADEDDDVSTDTPPMGSGEGRRYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVR7</accession>
    <name>A0A088RVR7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_262520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700071.1">
        <property type="nucleotide sequence ID" value="XM_010701769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVR7"/>
    <dbReference type="GeneID" id="22576155"/>
    <dbReference type="KEGG" id="lpan:LPMP_262520"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260029900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_262520"/>
    <dbReference type="eggNOG" id="ENOG502RXEN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="278199at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="786" mass="86902" checksum="AE661B883C060F73" modified="2014-11-26" version="1">MPGTRPVETVLKALRRHAQLQRWQRQSKVPSAPGAATTTATTRPTHADHTLPQHRLLMSSSTSAESSTSALSSSSNFPALHVSQSLQRAYELRDTAQASSPMQRRLVKYLRCSTSKAESVEAFFLIARTHQEALSPATVADFTSTMLRHNVAAQMGVEAYEAALADAVGVAEDSPWGHIGPAEARAFVLYQARRLERYAVKGTSFHEQLSLTLEGADNAVVALTEHQLRKDVASSSALPVSCDTLVELIHLDISWSTALEVYKYAKELTRVDPPADMTARLMGLMTGYKTNGLGSRPWEMALELYDALLESGYDVPLDAHASALDAVWRCGESFVKLHNSLSPTDRDRMWDALVRIRERVSDAQVTGDAGCRFTEALIKAAGAAGRWEATVQLLSDMDVTLAATSHRLLVPTAESFLFTMASCNTAHNAAHASALYETFCALYTLRSAHPEALLTYLQSLRHVESLSAEIGPQVEALVMDGNGLDRPCCVVCLQLLSSQRVRTKQVEKWRVAQTLLRMYDSNPWPQQPQVRKAELQTVFRCCHLIAAAAASDEKLSPLAAAPCPLLTELRAYLVSVFGRDSRECQWLDDTEVYSLLTTQRWECALAIYQRQVVQRPLARVTDLPIPLRQARHMLAQTLLRCSRAAADVGRERENFFLDEEQGAQERAKTVDFLAFVVRTVREVYAGTGDTVCLSIVAELLLHQALHVPRARERQQLALDAMRELSCGLASAVTPRLIDLVSQALSITEEHVHSVLVDGSAQLRAKALERDRQRRIRASGCLEKIFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVW0</accession>
    <name>A0A088RVW0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_291000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700708.1">
        <property type="nucleotide sequence ID" value="XM_010702406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVW0"/>
    <dbReference type="GeneID" id="22576864"/>
    <dbReference type="KEGG" id="lpan:LPMP_291000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290014100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_291000"/>
    <dbReference type="eggNOG" id="ENOG502RMJ1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271210at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="46841" checksum="1A4EC3DF11CB87A4" modified="2014-11-26" version="1">MDADAARVGSTSVHAGQSLFQRSGIDTGVYYYNAPRALSTAEEDTLGVGTLEASHRSRLHILREQALHRGAAAGPLETDPAAEALSGDVSGVGSSGSITREQSMFAASHEFAAVDKTPQKLEDERHRATPKPIVKQLEADIKKLEYYQGTPHYDKLLADFRAKYNAEQTPKKGAKGPVYMADEVERGLEGQPIDYHHSSTKLQAQLLSGPRAYDLVTIMQQQGIMRFQGYAFPPTAELGKLKGDGDGLKALHDAHKSHPLVAQVRRGMNALIGRNDARDDYVAMEDKSKEDTHLLYRTLGLGAVQRRQLRYMLTDFDHADRNTTFHVMMSYPYTDWLHVFYMMLVGWCLYQLQVRCGAYDFYDEYLGLDLRQVPRLQKPVLAGITIIVMVFFFFQPLLVASIATTRAYRIAMKRPIGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RW88</accession>
    <name>A0A088RW88_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Patatin-like phospholipase, putative</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_302100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701233.1">
        <property type="nucleotide sequence ID" value="XM_010702931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RW88"/>
    <dbReference type="GeneID" id="22577263"/>
    <dbReference type="KEGG" id="lpan:LPMP_302100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300025500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_302100"/>
    <dbReference type="eggNOG" id="KOG2214">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10049244at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021771">
        <property type="entry name" value="Triacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF10">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11815">
        <property type="entry name" value="DUF3336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="651"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="7">
        <location>
            <begin position="408"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="4">
        <location>
            <begin position="439"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="220"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="441"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO00433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="764" mass="82409" checksum="6DDDA73DF9C8FC43" modified="2014-11-26" version="1">MNTTESYATFVEAAASLDHYCGVEKWAQDAPPLEHCNAVGLLIDATAAQHLIQTNNLPGMETFLCSLLKRNAHGLMDASIYRYYHTAPHCLEDYTDNIELLIKAYAAGTWRGESAVSDCGASGERCTPATSTASLLRELRPCWVRLEASADAQMRSPLLAGTRGPGWTSKQSRSSAALPTVDVTSKIQLMWQAQLRKTILTSPALWTAATAAPSRRHSISTSLHGLGSNSTSTALPLTDTSTGTARTSASTLAGEKGTSLVGADVSLVPATVLQSCVIPKPFYDAMRAGEFASASLPSSPLVRFEDTATFPAASSLSAGASKAALPSIVSGSVASVRPSPAVTLAQQLRSSCASLCRFLDCGASSSTQSQQHYPHQQRLSVHQSTAPSAGHRLQVLRKVLHSYGRTALVLSGGSSMGTYHAGVARALHEAGVLPDILCGSSAGSIIAAMICTKSPDELHAFMQSHVLSTEAMHMSPFGEDSGLPGKLRRFFKTGFLMDVRSLMECIRGQCGDMTFLEAYQLSGKVLNVSVTRSQQEGMPSDRHVLLNYLTAPDVLIWSAVSASCALPGLFTAVQLIEKPSVGAGTFVPYLPGDLWCDGSVAQDIPRRLLIQLFGVNYLIVSQVNPYVIPFLRPPQSYHITETCGSGLARLWFAWVDVCGWVLTVLFSLHLFPRFGRFEVLFMPFAQFYSGDLTIQPIDSVMKAVPDYLNLVNNPSADYISYVASRAQSRTWPLVARIRLATSIERCLQREIHALEAMEYRNQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWF6</accession>
    <name>A0A088RWF6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_300050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0220 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701041.1">
        <property type="nucleotide sequence ID" value="XM_010702739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWF6"/>
    <dbReference type="GeneID" id="22577059"/>
    <dbReference type="KEGG" id="lpan:LPMP_300050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300005500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_300050"/>
    <dbReference type="eggNOG" id="ENOG502SAPX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268928at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007919">
        <property type="entry name" value="UPF0220"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13180">
        <property type="entry name" value="SMALL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05255">
        <property type="entry name" value="UPF0220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO00241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="141" mass="15505" checksum="CFD12663D133E6A3" modified="2014-11-26" version="1">MDLHNPNLPPITAGILYGLSLILFIDGLVLAQKESSVENHFSFVQCIPAIFSTMGLLLLHLVSPSEVKEGDGRGRVLLFMSWLSMFGSSVGALAIVFFCYTGKQTRTRAAPGVSLVLYTCLAPVITSLLWWSRRVSDSNEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWH7</accession>
    <name>A0A088RWH7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ribosomal biogenesis methyltransferase, putative</fullName>
            <ecNumber evidence="10">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_272250</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="10"/>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700311.1">
        <property type="nucleotide sequence ID" value="XM_010702009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWH7"/>
    <dbReference type="GeneID" id="22576403"/>
    <dbReference type="KEGG" id="lpan:LPMP_272250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270030800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_272250"/>
    <dbReference type="eggNOG" id="KOG3073">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269804at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070037">
        <property type="term" value="F:rRNA (pseudouridine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.10:FF:000043">
        <property type="entry name" value="EMG1/NEP1 methyltransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005304">
        <property type="entry name" value="Rbsml_bgen_MeTrfase_EMG1/NEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636">
        <property type="entry name" value="NEP1/MRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636:SF5">
        <property type="entry name" value="RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE NEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03587">
        <property type="entry name" value="EMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="199"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN99604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="246" mass="26496" checksum="5534813A4863F329" modified="2014-11-26" version="1">MGLVDAYDRAATTEIANESLKDVRPDIVHQCLLALFDSDLAYQHRLRVYISLFVRQGKVIEVSPALRPPRTYARFRGLMSALLRDGRICSTDGQVLMRLMPGSVAPIIPHGADVVGLTNSLSSPIVTATQLAQQAAAAPVDDSLQGGIKHVTAFYCISCTDDCNLDGIDYITKSVCLSAYPMTAHVQCARVCEGHTRMEPADSLSSSTAAMEVGGGQAKTGRSSTSEPSRRSGEIFPVHQAEDNER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RX25</accession>
    <name>A0A088RX25_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_310900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701478.1">
        <property type="nucleotide sequence ID" value="XM_010703176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RX25"/>
    <dbReference type="GeneID" id="22577516"/>
    <dbReference type="KEGG" id="lpan:LPMP_310900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310015600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_310900"/>
    <dbReference type="eggNOG" id="ENOG502RVAA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272039at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056661">
        <property type="entry name" value="DUF7759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056663">
        <property type="entry name" value="DUF7761"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056664">
        <property type="entry name" value="DUF7762"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42262:SF2">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42262">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24945">
        <property type="entry name" value="DUF7759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24952">
        <property type="entry name" value="DUF7761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24953">
        <property type="entry name" value="DUF7762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7761" evidence="3">
        <location>
            <begin position="257"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7762" evidence="4">
        <location>
            <begin position="376"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7759" evidence="2">
        <location>
            <begin position="649"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="624"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="488"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="624"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO00678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="758" mass="81517" checksum="FA372DF417E3D4F0" modified="2014-11-26" version="1">MSGTTLTEALNRLSNCKEPADLIYSKDAARILGSAAPPQTVTPTVSPPHGHSPVDEYSVLLARRIGTMVARLNELSSPTSQVVLTPRMALCELMDIVRQALYTSLPADMQKATAPTDKAAVVKQFHSYASSRQVPIGFAVEGLYVVSYVSVKLRVELVTLQLQRRIQEELSKKDTQTSEASVAALVVTQTLLEDFLAVYKNIMLTMPIIKAAAREGSVSEAAQRLAPVYPQYYYQLCDWVLVLESTMNSPPISYTQVKRVCIDEQNGVVVVDLHRPTPVTPWGLLLNEQGLLVDIDVSLRVFEKARTLHDLLQSTPQGASIVQIQGQSVDGVAHGDYAAYTKRLLQTLQSMTVGNRSVQLVLKSSAFKADARSLPVEVAFFSPPQGGEGTSGQRVTLVLRRQSTAAEWGFTVDEQLYWHASLTSILSNSAGAFVREYGKHLRLLAVNGVEALHATQVQLLIEAAETVVLELLVMPKDAQDRLAAARSTTTPTPVAMATPTSKAPSVAAAEPPNKISGGRLGGGRVEAAMEKFLQQRSAAPSAVAPSIAMETPLVRASSVAPAPAAAAAIVSAEDAKKGKKHGVKPKALKKALAESTVAQAAATSHPAAVPSEGTIAQCGGVMEAGKAASSEGEAPSAGPQQMEGEPGVPCTFDNQVKLIHLGEDEMILERPSVDTPWGLPIGRLTDPSEAPQQLPLRLMSLPSSRKARVRQHPLFRSFKQQPSTWYIAQVNDRPASDAEATLKHISQLTRMTLRFLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXF2</accession>
    <name>A0A088RXF2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_312530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701638.1">
        <property type="nucleotide sequence ID" value="XM_010703336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22577679"/>
    <dbReference type="KEGG" id="lpan:LPMP_312530"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310033000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_312530"/>
    <dbReference type="eggNOG" id="ENOG502RYCM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273222at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="660"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1224"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="598"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="615"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="671"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1237"/>
            <end position="1246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1313" mass="144331" checksum="628E90234470FBF3" modified="2014-11-26" version="1">MPAPSSTRPSRASLVCVLADARQGRQSRDPASAQLQWYLIQWFPRNLWPSIYRAPSRGAQGTAARANVYRQFCRDPPRVSHEWSAALQLVELARLVDKTPDTSPSRVHQGARLPTRTPTPESDSVVQATEHLLRYGVFPPSGWALTLRLLHKWREKQPPARPQVFPTSLSPPAAAQLLYHISLSPPSQRAWQDALRLYQLCAREAHAPSTSDRPLPTKTVEPPSPPRRTSDTAAHSAFLKALRHMTLTTCLRAGEWERGLHFYYHTLYQRDLPGPITTSYLVQQLGRSGQWAAVLQVYELCVKLLHAQRHQCKQQRQQQRLPPHREKCFSQEWGTTLSMAMAAAQNSPGAPTSTLATMVQQLQPDLGATPTLSTDVTRVTPSFSPPLVRLSGHFLSAVQALPSEKDRLVVLDLARRRSLLDIFKLIRGLVSKHRWEEALALFNEAMCTTSLRTLHPDPRDRDLPALHASAESTIRKPLGLSRREIGEARLSFLHEATIDSVAVVVAALNRHRGATRRRRTDALQESEVAHRSPTAAEVSSTRLMLNDREVECVFSKTLALNEEGPRALSLAARGTRAYFWRYCLEILAFNYGALPCGDTSTEASRSPENANEGHSSSPQPRRTPTPAALSFLLRHPRFPWHVALRLLQHYGVLETHPGERATATMDATGPRTASPSSADQRTRTSSPPTPCSLALAAAVELLRTQGKLLVAEKLALKSLEKEMAEEALGAGTGVSLSAALLRVAQYPTLRSVLLERENERLRVEGSTLFHLLQESTRVRRVQAEGHGDDGVYGTSCGAVSTSSSPWWASSAAFFHHPSGRALTVVWLLMQRHMHPKMTTTDAARYEGPTNFPASLFLCVPPPPAPTVPIASLAAPLRSWLLAYPVAVHCEVLCVIKSLTSPSDLPVSSTSSSAEASLCYVQRWVWVRRYLASLAMHFSAPCTDALTCKEGESLVEESGNAATDAVAREAYYGATFEAVVSLLDAPVSWIGASHDEVGHGMQMGVVTDATAARHRDEAPQSSAQRVQQLHQLLERAIVRYRCLPPTHMLLPNQLNRLLPPLPQSSLRFTGVSAEEVGAQRDSFDRGGACTERCAVALHLVRLVLGTIQDAREQCTVEPVLLHNLLKLCCRVAEYDKASLTAAEEAAPTDIDNSATVSRAGATLVRLQCELCGLETVRPGTLSLLYHLCAAAQSRASSYGHTIPRQVALATTCYLLEAQTAAAARKNQENQRQEGVLSRVTSSSSRAPNGQRRLDSPGLSCAVQGRHCQLYFSLLGWEDALEVWYRAFPHEVLTQLSSNPVAVEACLSLGESHQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXF4</accession>
    <name>A0A088RXF4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_310310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701421.1">
        <property type="nucleotide sequence ID" value="XM_010703119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXF4"/>
    <dbReference type="GeneID" id="22577457"/>
    <dbReference type="KEGG" id="lpan:LPMP_310310"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310008100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_310310"/>
    <dbReference type="eggNOG" id="ENOG502RQTK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270385at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140284">
        <property type="term" value="C:endoplasmic reticulum-endosome membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055777">
        <property type="entry name" value="DUF7353"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053012">
        <property type="entry name" value="ER-organelle_contact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46384:SF2">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46384">
        <property type="entry name" value="MOTILE SPERM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24044">
        <property type="entry name" value="DUF7353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="445"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="537"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="569"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="629"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="659"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="691"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="719"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="748"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="774"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="805"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="73"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1116" mass="124255" checksum="01B18DEA2E61C1F4" modified="2014-11-26" version="1">MPGYTSLSDLGTLAISHRDEVDRVKEQLDIKHGYFDAWIYGFLANKKFSVDETVAKLHRRFAMEANELASYELTDYMRESLRQGIMFEIGKDKAGRVAFYINTRRDRPQAKYRDEKRRSFDMIISYGTRLRKENKRCQMVMLINQDGASLLQNVDMTFQADIALRISKFYPGVVDKMYICKMSRTLAIMAKPIFKHLPAIVADRIQIIDDTDIKQGALLDLFDAEVLPVELGGQNKCDEEGLWSAYADRVEKYYAELKRAVNERGLTVKDYELESIGIDSGTAHEEGATSGAAKTSQADALVQSVSSLSAEPMRSLWVSSQYMDDANQSAHPDLKPLMTCLTERSSLLLPEYDGTGKEETGAGATMPWAEVVAPLPRSLALFFLDELLRWRTTVESSECGERYKILDNFASGLKTTTELGIRGLDVSDRKWYVGVPYPLRALYRLLLVGITLINMIYFAAALVFCAVFCASIIITLFFGFFANPFYVFPLGAVLLMVAIQGASLCTRAADCLLAVYNSNIIPLFEHLGSYWGTVAEVILFFVLVITQFIIFFVYAVHSNPLRGLEVSFATGWLSALLVTAFTHIFFFTGVFASPTTRDRDNRLAALPFLLALNFGNASKDQLKELDARFMLRTSAYVICGIPLVISLLLGISFLLSHIVFLYVATFTATLVAAYVVHYYSDALSNSLSGSLLRLTLWMMTLVWCYVTFALGFQSHNHRYGTSAIVASVLNGAFVSLAISCLRRPGRSWLLRVSYIIVMTYIGGCWIMVFPLVGWHMGLFCLAIMIHNVLNIIFAPRTLANIHASFFLVAAVMLLGVSCVLLGWYGTSLMTTKPQSLARGPPCATALSQLELYHRYPVCTLQLGQDNSFRVVDIALLKELVGARTNVTRTVDFNNWFGTRGITYNGVVKEFEADGMPWEMHEFLLPATANTTLLVLNNRYAMSSIVAMVGWVDAIALSPLSIFMPYDWIDVMVHIMSFATRLIPFAARNLATDLRDFVHYKKDLLQTKIILTGGGVAGGFLSAAAVQAKTQAIVFASPGLLHCSRKLGVSFEGYHRYVLSIGAYYGVLNYIGGQDSTVSQRVLCDGSALYCIRPQFFSRALLAACGDVEGRRHVAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXK8</accession>
    <name>A0A088RXK8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glycosomal transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">GAT1</name>
        <name evidence="10" type="ORF">LPMP_310520</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701441.1">
        <property type="nucleotide sequence ID" value="XM_010703139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXK8"/>
    <dbReference type="GeneID" id="22577478"/>
    <dbReference type="KEGG" id="lpan:LPMP_310520"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310010200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_310520"/>
    <dbReference type="eggNOG" id="KOG0060">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF67">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="508"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="49"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="763"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="777"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="806"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIO00641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="836" mass="92911" checksum="530979618E580B28" modified="2014-11-26" version="1">MVSSEVLGEYVREYAASRLRDPVMTSSLGSSLAFLAIMYATSSGRQLAKAMPPPSIRGLHGTIERGNSGDGGRDGSSPASVLQSMPTSPHSPVPRAGALSSAIPSDSTAAAEPYGEQVSQEKSVPQRFMQLLRVAIPNYHGREARSIYIIFVMILARAYVSVRLVSVSGLVSRSAIEGNLRHVMRALVVFVATCVPATLLHVTLDYYSELLGLHFRDNLATYFSDRYLKHRVFFQLAGLHGVDRVDQRITEDVRNWSRVVATLFTGIPRPLVDAITFSFTLARQTGWKGTFMTWSYYVSFAVWVVCCAPNLDLMVQQRMTKEGEVRGAHQSLLTHAEEITVTKGFRFYEKLLQRLFKAVTDQSRYAAYVQSRFNFTEVLHNKYGSVLVGYVVCSMAAMHQRNVAKTAEAATATLTCASYTFKTLATAIGKFMWNIKWAFVAVGYTRRLAQLLNALDHADVLVKMQMDCTAQSPVVHSPPGTLSMRGNDGKPMVNYAGSFGHIVRGNHIEFVDVPLVLPTGECLCNSMSFYVKPGMNLLIIGRNGCGKSSTFRLLGELWQLRGGRIEKPEAEQLYYVPQRPYMYDGTLLEQVIYPLKKKDLTVGEAELYGYLQMAGLDYVFTKLNMSWETRLAWRDGTLSLGEQQRLAMARLFFHRPRFAILDECSSLVDLDVERQMYDRCVELGITVITIAHRRSVWQYHNWILYFDGNGGYMFSPLQYEPGVSALVLTSVRSASDSSLIGTEVCLPITDRLCSEDAAAAGVEGQPAQLITTTGKAEAPKTPREEASAEKAEADGNGERTHGSPRWSRRRRFHKHHASGVNKAVGFETPAETDGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXP0</accession>
    <name>A0A088RXP0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sodium stibogluconate resistance protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_310880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00676.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701476.1">
        <property type="nucleotide sequence ID" value="XM_010703174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXP0"/>
    <dbReference type="GeneID" id="22577514"/>
    <dbReference type="KEGG" id="lpan:LPMP_310880"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000051400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_310880"/>
    <dbReference type="eggNOG" id="ENOG502SH3F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="261177at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40744:SF1">
        <property type="entry name" value="SODIUM STIBOGLUCONATE RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40744">
        <property type="entry name" value="SODIUM STIBOGLUCONATE RESISTANCE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO00676.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="628" mass="69172" checksum="8EDBA611F796C812" modified="2026-01-28" version="2">MGSKPSSVPKEGEGHPEVFYRGVQAAREGRFTLSEVYFDQALTRHPGRHFWDTFTKAVLQKERSACPEGGGTSPSRGDAEKVDADPGVGGLLNPWGEAQPPSAFGGGMNRADDLAGGENIRAENGQGGLPGSGDDGDAAELADAMASDAQPTHGTKVADIYLPLDGDLFHVMDYYRLLADIGHTYLQLIPSTAYVEKVTGLAARYCLFTISHTQTLLHCLALWKEANLGDGGGFIDYEKRRNLKLGSEHYTDFISDPQSSDRRGQKWRTMDRTASLFFTLGLLEANCRYYCLSFLVNYCSLLLRSYSGLSEQRKINRVHANIVEHLDMANRMVLDLANDYPHEYLSHLIMENVPRPSSGDRDFHSSMGASSHAGSRNILSLSSDQHRHLYASGCPWTPTQSALIPLILLRSIRLSVQETVSRTAQAQLRSPAQRLSYHYTGWNFDTGLVIVPGCNLYMLRKSLPGFVPGKSTLAHHITMAEQEEFHMPIGGAEVRLRDGSVAVPVPGHGNDAACGSRHNSRVPEDSAAAAKREARIKKCEEKLIMRRRDINTDLNLSDERTCVALCLEEACVLALPSLFLSLALRKVSGEVENVEYILPLRALGTGLYGPESSEWNLMSSILRKHLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXX0</accession>
    <name>A0A088RXX0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="9">1.3.1.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LPMP_311800</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5,6-dihydrouridine(16) in tRNA + NAD(+) = uridine(16) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53380"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:53382"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5,6-dihydrouridine(16) in tRNA + NADP(+) = uridine(16) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53376"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:53378"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5,6-dihydrouridine(17) in tRNA + NAD(+) = uridine(17) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53372"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:53374"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>5,6-dihydrouridine(17) in tRNA + NADP(+) = uridine(17) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53368"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:53370"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Dus family. Dus1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.88" evidence="9"/>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701571.1">
        <property type="nucleotide sequence ID" value="XM_010703269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXX0"/>
    <dbReference type="GeneID" id="22577606"/>
    <dbReference type="KEGG" id="lpan:LPMP_311800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310024900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_311800"/>
    <dbReference type="eggNOG" id="KOG2335">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272303at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF5">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(16_17) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="15">
        <location>
            <begin position="117"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="DUS-like FMN-binding" evidence="15">
        <location>
            <begin position="279"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="DUS-like FMN-binding" evidence="15">
        <location>
            <begin position="386"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="68"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AIO00771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="663" mass="72623" checksum="199E51CBE76BD9AD" modified="2014-11-26" version="1">MAYNEKQLKAYRQLIAEGKPFRSTTCPYCNGHRDATVKHVHPSTKPSSAWDFWNDVLVRKYAAVQSPATRANMETSVTDSSEVRGTPRSASNEASKNEAVVEAQHLDVISSPRMFVVGPMVDQSELPFRMLCRQYGATVAYTPMLHAKSFAEGAAYRSHFLSVTPPEEVKAAMEAPFASPSVSAGEHSGGSNTRTGVGTDGEDAVADVALVDRPCIVQFCGNDPDIVLRAARLAVLGEQAAAGEQTVANYRVSTAPVYPVHVRVNGSSLEEEPEHRLYQCDAVDLNLGCPQGIARRGHYGSFLMEDWELIHTIVHTLHVELEVPVTVKIRVFDHPGHAEAADNDRECATHCSPAACVEEEDAAAAAAVVGTLPKPLEEGFDEALTILYARMIRDAGAQVLCIHGRTREMKGQHTGTANMELIRRVRLALSGTIPVISNGNVRTYDDVIAHLQETRCEGHMCAEPLLWDPKLFSNPSQPVMPGRTHSADKATRLSALHTALVYMQWVHHYPVDIGFVKAHLFKMCFHSYELHTRFREELCQLKTSITAMKKVEKWNTMGVMDTMQVCATPRTEELTALSFAVHEEVDEEESAAVVAAAAAVPLSPSAFEQLVGAIEAHLRALMEAEHRCSEAGAQPKSAQVEKAKAKQELVDIWEEGGDLGIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXY1</accession>
    <name>A0A088RXY1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_312030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701591.1">
        <property type="nucleotide sequence ID" value="XM_010703289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXY1"/>
    <dbReference type="GeneID" id="22577629"/>
    <dbReference type="KEGG" id="lpan:LPMP_312030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310027200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_312030"/>
    <dbReference type="eggNOG" id="ENOG502SKAX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266248at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="772" mass="82687" checksum="9C787DF0A779FB20" modified="2014-11-26" version="1">MPARGSPQPCKRFGTFGDPHREPTQAEREFYASLARIRTKSKAEREKLPVEKKNQEDIERENNRGWTSQEKSANKLLSAGRRSLTPGAPETGNALTVPCPPPRDHRLTVLSAVGLPSRTTPPVWEPNRHEARSCTASEDTSDCKRTSERRRGFGFNEEHTPEGLYKPEDSILLPSRYRSASPSQESPPCGQRARRVLRGSLADASEAPERAPDLPLGAQLLEELPRMKVTLASQTSAQTFPKNGAVDPSSAMGGNGSGGNIDMSRVAHLSEDEMGMESRIDQALDAFHRKHSSGGSMIRGLTDEQVETLEQLLAKRRKLCSVAVAAHSSPSKPPAPHPPEARAVIEERLAAPDASPKATKINPMTKQGTTQEAAAQKKAALGSLHSTPMSTPRAVAAAGVASLAQVATLPPLARAPLNEVVPKATLVRAPSPLSATETVCAVPSPTITQSHPILHANDTERHILTTSSETRKEEHRPKPACVFNRSRGASPSRSGSGAFLCVIPCTSGVASRGGLAEKEGTRAPQNTSRTEMRTQARVASSAETVEEACRQYAEQCRRDAQELHISIEQQRQRVGAAPRKVDSISPNSITHISAVILPTPTGEVIGSWSQPFTPHPRESENALPFTASLVYERSPTVASRISARTISHMDTTSIAGRCSTSSAVSVAEETGKLIMMAYHNADSPQVNQLHINTGALDLSQCVLSDAPAHTASSGASGSSAWGDDASRTSSDLYTLSSLLEYQSAISPHQQVTGKTPTPLSSTEVLLLPFSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXZ1</accession>
    <name>A0A088RXZ1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_312850</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701669.1">
        <property type="nucleotide sequence ID" value="XM_010703367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXZ1"/>
    <dbReference type="GeneID" id="22577711"/>
    <dbReference type="KEGG" id="lpan:LPMP_312850"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310036300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_312850"/>
    <dbReference type="eggNOG" id="KOG2175">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27483at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055236">
        <property type="entry name" value="EVH1_PP4R3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006887">
        <property type="entry name" value="P4R3-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051137">
        <property type="entry name" value="PP4R3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318">
        <property type="entry name" value="ATP SYNTHASE GAMMA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22972">
        <property type="entry name" value="EVH1_PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04802">
        <property type="entry name" value="PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PP4R3 EVH1-like" evidence="5">
        <location>
            <begin position="75"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central" evidence="4">
        <location>
            <begin position="184"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="843"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="895"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="938"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="848"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="900"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="961"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="977"/>
            <end position="988"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO00869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="988" mass="107160" checksum="F82FEAAE4E206C95" modified="2014-11-26" version="1">MESADPITKAKLFASHEAGEWIPIGLGVVSIVKEPLPTSSVDGSIDGGCDPGVSIRGGGKRGKATDEEASTKLAARLQMFSTDNPNDLLLSSCVSLDDIYTIQDETILVWYDESVSNDLACSFDNKEGCDLIYRQIKSYQQSERLRRVQDERVPALADRFLVHPHNLAGILDAAQSQNKRFGLYVREDPQYFTKLAQLFHISREKEETTSMELIAHIVLALFQSPYNTEGKIVAQLVENERIDDCIDIVQYGLGRRDKESGFVSFEERRATFHDPCHLPESMLPRIHVLYSCGYLRDLIPLSLEPADAASYSLLSTFTLRFTMTLMTDIVASPTILPNAFRAAVDAVRLDSPAVDPASIHPGKVAHLFELAAFIGDVAKTVKNAMIGIDTRTEIFSSLVRVGVLPFLTTVLECALRYYEGALTYPPAQQWAVKPPRAVQLVCDTLYSCAAHFPECIEDLVAEANAVPGRCLLQLLLRTITVVRSSAEAQSVVDVVQCCGVGVPLTLAMFGDNVQLEARRHEVMRFWIEGNVVDRPPLFYLAVHLAQLLEQAAGVTVATLPLRGGTNGVRLPFTAGALQLSLVQERQVVYGLRVIAVIISKADSSRCNSLLELLTLSKLMPALATTLVSPQRRMANLQSSVTSFLATVLNRRDARLVTLATGDLTPSLLHTALLLYLQCGHRDNLLSSSLAHLIAAVCEGVHREKLQGTFSMNSGGSFGPSPFVTILRSDDSISKTEQTFPASVPPARPFEAVASGILSQFGEHLAKKVPVLYERLQKALEETPEQAQLAEAESSSLTSSVERSGISGFADFDAAAIDFGLESPLGTPIVDGGSEARLRGLIHTTSTTSDEDNEAEDDPLASLSSIDDDSDNEEREASVPPPAQTLAYLPSAADFSPGATAASSAAEQRSGDTTCVPSSAVPTSLASFAVTTLDCADPPSGRNSLLEDEESRLPRRASLKRGRSDCDKLNDNEEEESEARRVHVEESAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RY44</accession>
    <name>A0A088RY44_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_312880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701671.1">
        <property type="nucleotide sequence ID" value="XM_010703369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RY44"/>
    <dbReference type="GeneID" id="22577714"/>
    <dbReference type="KEGG" id="lpan:LPMP_312880"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310036900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_312880"/>
    <dbReference type="eggNOG" id="ENOG502SJ9H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266168at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="91"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="456" mass="49895" checksum="3836733E9B5DF95A" modified="2014-11-26" version="1">MASNGSSSPSPVPHRRQSAKKSALNVASRVLEATSTFAEYAERRHELLAAINDGLEDHVRIMEEQAKQAVAHASAVAEVSRAQETECLEYIEGLEVRIRSLQRTKRECAAELNAFRAALTTDRQGLEEELHDLHRAVAEARRQKLLAQEEQEHYEMLRDAAKRRYELAESHLENFTAKVEHRFQEAVASLQASVQERKRWADEQCALNEKRVHEASWRAEQSHFGDFPCDAPEEAVRASSVTFATPCAAVVEPTCMHQLERDVAALGASAASRLQLIVEQQNAAEDRLDRPSLHITGEGCDSISALCHTSAQAVSEDENEIWKGKQRDTFDSVSASDVICPLSASEVAVKHTLMEVCATAASASPTTRAKAPARPHESSSRAAAPLRIATATPSVSWSAPSPIPQKVLLSAPVRKSSLLESSPPQSARAASPERRLIDDLPCSADAFATVFTARKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYG5</accession>
    <name>A0A088RYG5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_321580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_010703542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYG5"/>
    <dbReference type="GeneID" id="22577899"/>
    <dbReference type="KEGG" id="lpan:LPMP_321580"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320021400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_321580"/>
    <dbReference type="eggNOG" id="ENOG502S825">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="260969at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="375" mass="41628" checksum="D68DCAE69224AD4B" modified="2014-11-26" version="1">MITSAPDLSDGLVTLPAAELRESLENILSAISASAHSCSEESRALEVQRQRVLTLLFKLDRRQTSFDSLDTTVPRHGTLLSPVSAETTVEHGGSLHVFVRNSESADARTDVPGDQFRTAFREDDKVHARSMPHPYHRCLLGNLFSQSIQRDMTTPLACMFPCVSSPPSLSRGEADGLEGDGEKDSGVCAASTRLQQMGQLCCSPAALPSFSNDEGGSGRGWHDLASRFQRHSRVDEDSPKPQEMRSCAPSAQVNTQNSRQWNSDTTVSRSFWINVWPCYGGTSASHTQHPTRILVRGRYRYIEEVMEKAAKLTNCRPASHGFYTPDGCPIRNLESLVPEQHYLLFPFGGFYRKQTVPTALLWQLYSDARHIVQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYI0</accession>
    <name>A0A088RYI0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_321200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701806.1">
        <property type="nucleotide sequence ID" value="XM_010703504.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22577861"/>
    <dbReference type="KEGG" id="lpan:LPMP_321200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320017300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_321200"/>
    <dbReference type="eggNOG" id="ENOG502SFG2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273683at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="643"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="701"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="803"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="859"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1248"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1312"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1442"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1539"/>
            <end position="1624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
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        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
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        <location>
            <begin position="469"/>
            <end position="478"/>
        </location>
    </feature>
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        <location>
            <begin position="522"/>
            <end position="533"/>
        </location>
    </feature>
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        <location>
            <begin position="673"/>
            <end position="683"/>
        </location>
    </feature>
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        <location>
            <begin position="771"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1315"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1460"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1471"/>
            <end position="1493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1552"/>
            <end position="1587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1624" mass="173521" checksum="CCDB353DF51A84F6" modified="2014-11-26" version="1">MSEDKRPRFLQQTTSQLLHQQEALRKRREMLERESTKPPAMRFGTNTPPRNAARHGRSPLLSSSASERQTSHSTPPPSSGARRELNWSRPEDEKTAERAPMRFSMLFRPSPTPAVLARPRSATGLHTPSSPSLREVNTSDQVDARVTKFYKESSSPRTVSPHSPVQQRSRVECDRSPSENTTPRADVPVHLLRCSFPRPVQVIADEAAQVEVACTARGGATPARATVKLHASTPPPDSRVACAEEQDKVTGTAAFSNTFPVPRFTPISPVVAATAKRAQQTHEEEQRTPIRLAAGEFRTPRPLARLSTAVTPTVDYPAPVQGEDDGEQGTSSLDTRAGTASAVFPPLALLPQVLGAAEASVDMQEFAQPSRSTDEAPTHTEHGTVPTEMVYPIGSAEIGAPQEATSLSFTVASALPHRQTPSPPRRNDASPVPTTQDLIHSMQVSAEKQPHSRDRPTPSPVKWNSCRATATPSRTTSPLPTPVPPSNRLMTEFGSLTKKCCDRPTPVSLSSQPAGGDARNATAGTSSASPWPTTENIISSIMAGTSEGQRRGREVSAAATPHTVPREDDGVASGEFSNEEVDVPCTDSPNMEAPEKFDVNTHNEGEEFGRDDTLYTTLQTNATAHTPSPVPSDRQYGQSILASTTKRRCGRPTPSERHVSVAASEDSNGRAAHTTSASPQPSANHLLLSLDVSIEKSCQRCKPAERAPEAEGSGSGDEATRNTPGHLTAIRTPSPTPTPEHVIASLQASAEKRTRSGAIDTSREPKDFSAATMTSASCGSYQSPTLTPQNVKDSMQKLMREQQQMARSDAPPPIRPWTEGASKDTANGASCAGTWNASASPVVTAEDVDTALATLEREQRYHSRSSRAPRVSGISSEEENTALPRESVVFAVKVAEAVHMKAIHDTHVSSPQGTVSPSVVSPVPSELAVASAMFFDCVSAPPTPALESLVAAKRATGSPELPIPELESAHVPPQFYNLQREVAAIAEGRSRTCTPPPPLQVSELRSPLPVPAMSLEEGDTTSADVSLEQRDVAVSASLHEQQDLISSYTAAVKRDTEDEEMARRSSLILVHPTKTPQPLLQHPHEPMPTVSAPSTAPVQVPCTLTPPRRHPLQQERFLTSEGGPVGNACSAHRESPLPRPVSLRSQVPLEKVMRVSHTHPHSRSPAPGWRAPCASAFKGDVMPAQLSWTGVQPPKRCTTAMQHDEDTRLQADLFDPKNDWMDLIEPLRPQTITVSPQGGTVVYTEHPLTSPAGDPARPVGPMSPSISRKRSRSAQTPLAAARQIAVATPASIALTMDGSASSGAKSVRVAATPISDVSQTPRSSTRGRKSQAEELLDMLPAEVIAEVARIEEAEEVAAAASADLGDCRPSLGSSAGRFSGASDGDSTLGLVSTISQRVSKRPRRTYHNYDYYIQYLEGLASSSAKKARKCSGRRMHRAVMKDVASNTAKTVVQRGGGDQSPATATVSTAESPAPRGSGSQSASSRGSGRAAARTKVSTMHASEEVVVSPQALSFTPVGGRRQLEVSTCLSAELQKALFQQPSPAKAKRQHNPCRTSPKLSAKSTQTAKKSPTTSPKNEGSAISTTKQKAAKKAPPSMRGKRSVKKFCTAKSMRLPRRGAKDSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYL5</accession>
    <name>A0A088RYL5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_321500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701836.1">
        <property type="nucleotide sequence ID" value="XM_010703534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYL5"/>
    <dbReference type="GeneID" id="22577891"/>
    <dbReference type="KEGG" id="lpan:LPMP_321500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320020600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_321500"/>
    <dbReference type="eggNOG" id="ENOG502R8F2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="278233at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839149" evidence="1">
        <location>
            <begin position="23"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="687" mass="75184" checksum="E74EF0EF567E0397" modified="2014-11-26" version="1">MPFFGVDDILFLLASTTALLWAKRSDVVESGVYVAVKYLTDDRQEAARRAAAAGAAQGGTPTLLLKGFDLQTEATHPLSLQNYATRVETDPNPLVSTTLSATRAADRSDVTASVPLCVKESIYAQFCETPAVHQLPQVPHRHYNFHKRRPHVSLLATAPEEDVKECISSYSVAEVQSLFSKMEREALWEAVIHVSCGIHQAGQQLRYLNQHNVECALRTLLNTSHPDVALIYYFRFGEDMLVSDEILVALFYACRNDEQLSLELCHVLQPFKPHWTPAVYACCLTTTARFDYKQAIALYHAYMAAQRRQQVASQRTLRRVLASSSLLCEAGVVAAPAPLQLHYLYHVIIPLVVARDPASADAYVADMLVNDPKAAPEVLLKCLGLRKGQELAWRYLDDITSSISGSTVPEEVTKWVLAQRSIQCTEGAPADVAGLAIHLYRLRPSAMNMNTLLKLCAGPLDGREGPAGKAASADASKHESVAPASPANAASVCSELMRLASGRVVELTCLLHHMPLQSQLDAAVLARTITEQHASWGLATQFLSVMLRRKCFNVVSSLATHVARQGQWATAATSMAIYLSNQRAAMTAKEAKLCVESCVHAGQWASALFWVERAHAKGVALGPSTYDLVLGVSRHCSFEAAERVVMTMHAVGASCSEQGIFDFMETAAHHRKTANALCVLRHHNHVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYZ0</accession>
    <name>A0A088RYZ0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA (guanine(9)-N(1))-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.221</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_303030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>guanosine(9) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43156"/>
            <dbReference type="Rhea" id="RHEA-COMP:10367"/>
            <dbReference type="Rhea" id="RHEA-COMP:10368"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.221"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.221" evidence="1"/>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701325.1">
        <property type="nucleotide sequence ID" value="XM_010703023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYZ0"/>
    <dbReference type="GeneID" id="22577356"/>
    <dbReference type="KEGG" id="lpan:LPMP_303030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300035000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_303030"/>
    <dbReference type="eggNOG" id="KOG2967">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="278300at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052905">
        <property type="term" value="F:tRNA (guanosine(9)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18089">
        <property type="entry name" value="SPOUT_Trm10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.30:FF:000011">
        <property type="entry name" value="tRNA (Guanine-1)-methyltransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028564">
        <property type="entry name" value="MT_TRM10-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038459">
        <property type="entry name" value="MT_TRM10-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007356">
        <property type="entry name" value="tRNA_m1G_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563">
        <property type="entry name" value="TRNA (GUANINE-9-) METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563:SF13">
        <property type="entry name" value="TRNA METHYLTRANSFERASE 10 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51675">
        <property type="entry name" value="SAM_MT_TRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase TRM10-type" evidence="7">
        <location>
            <begin position="113"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="329"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="329"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="348"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO00525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="382" mass="42377" checksum="90535849E94698CA" modified="2014-11-26" version="1">MSRAAAAAATSPAMPCVSSSSLTSDIDAHIPNAHDARDGVTEASHSTLAEPRRQRKLWTEDEKRRFWRQKKLKKRERRKAVAADRQKAQQELWEHLSEEEKEARRTEATLLHERRRQAEAALVSRCEAQLANPHVPAIVFDLSFAWCMTVANTKSTVSQVKFSYSALRTAGFPFRPIITSLMGKEASDTEHDVTAQAAVLQTLENFEGFRRFPPVVTQAQHWSVLFEPNQVVFLTADAPDALTSIDPGTAYIVGAFVDHNAHKGLSYASAQRHGVRTARLPIRESVVLGNRCKVLTINHVVEVLIQYEHLRAAGTPDWAQAIDNALPTRRTRQVMKGRRKRRRVGEAGSDEERDDGDEGSDGDNSNCTPVNASDSPAADGCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZ71</accession>
    <name>A0A088RZ71_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PRA1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_331610</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PRA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702253.1">
        <property type="nucleotide sequence ID" value="XM_010703951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZ71"/>
    <dbReference type="GeneID" id="22578314"/>
    <dbReference type="KEGG" id="lpan:LPMP_331610"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330022700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_331610"/>
    <dbReference type="eggNOG" id="KOG3142">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="63113at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004895">
        <property type="entry name" value="Prenylated_rab_accept_PRA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317:SF47">
        <property type="entry name" value="PRA1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03208">
        <property type="entry name" value="PRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO01453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="228" mass="25061" checksum="ABFD328974ED8F43" modified="2014-11-26" version="1">MIGKISFVEGLAVGPGADGSTEAPAAHSAALAYPGSDEPLPSYASIIFSGSSTAVKVQQLYHVSRQHVMRNFTTLRPWSEFFDTTFFHSPSGVTDTVNRLNRNLPYFYANYLVLSFICSSYILLINLPFAVYTVMMVAWYMFIRNRSAIVAALAAQGASEEEQMVYIANRPFTVSQLYLMLVVFGVVGFYLTGGSSVIFWLSLTSLGVSVGHASMRRPPIQDSAFDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZH0</accession>
    <name>A0A088RZH0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3'-phosphate/5'-hydroxy nucleic acid ligase</fullName>
            <ecNumber evidence="1">6.5.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_330580</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP = a ribonucleotidyl-ribonucleotide-RNA + GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:68076"/>
            <dbReference type="Rhea" id="RHEA-COMP:10463"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83062"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10">Binds 2 manganese ions per subunit.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.8" evidence="1"/>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702151.1">
        <property type="nucleotide sequence ID" value="XM_010703849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZH0"/>
    <dbReference type="GeneID" id="22578211"/>
    <dbReference type="KEGG" id="lpan:LPMP_330580"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330010400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_330580"/>
    <dbReference type="eggNOG" id="KOG3833">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10249697at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003909">
        <property type="term" value="F:DNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170057">
        <property type="term" value="F:RNA ligase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042245">
        <property type="term" value="P:RNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1860.10">
        <property type="entry name" value="tRNA-splicing ligase RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001233">
        <property type="entry name" value="RtcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052915">
        <property type="entry name" value="RtcB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036025">
        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43749">
        <property type="entry name" value="RNA-SPLICING LIGASE RTCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43749:SF2">
        <property type="entry name" value="RNA-SPLICING LIGASE RTCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01139">
        <property type="entry name" value="RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103365">
        <property type="entry name" value="Hypothetical protein PH1602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 10" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="8">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="91"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="204"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="256"/>
            <end position="259"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="280"/>
            <end position="283"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIO01351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="351" mass="38898" checksum="B3257E0002D49ECE" modified="2014-11-26" version="1">MIAVETSLTAEDLPNTLEDLRLSIELAVPHGRTHGGCSAADAGSWRNGVPANVQQVWKKHLADDFQELCRRYAQVENTNNLNHLGTLGTGNHFIELCLDDQQPHKHVWVMLHSGSRGVGNRIGSVFIGLAKKDMEARMIHLPDADLAYLDEGTAHFSDYTFAVEWAQTYAWWNRQLMLDAVLAAMRECIVTPFTTVQAAVNCHHNYVERIRIPIREQRQEDHAASTPGQETFREQDVWLTRKGATSARMGELAVIPGSMGACSYIVRGKGNAASYCSCSHGAGRRYSRGEARRRFTLADHETATLGIECRKDIGVLDETPAAYKSIDAVLAAQDDLVEVVTELRQVLCVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZK3</accession>
    <name>A0A088RZK3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_332920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702383.1">
        <property type="nucleotide sequence ID" value="XM_010704081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZK3"/>
    <dbReference type="GeneID" id="22578445"/>
    <dbReference type="KEGG" id="lpan:LPMP_332920"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330037200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_332920"/>
    <dbReference type="eggNOG" id="ENOG502S4UG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269730at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40736:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO01583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="152" mass="17496" checksum="0AEDFBADF2F8EDA1" modified="2014-11-26" version="1">MSSSAQAAIAKRTTSTLQRLVVEPFMNTAHKIEDHSVRKMQSMEPAMAEWVKKQEASGADAATISRQRFLREQHQLMSYRVVRFFEECRYIASGQYYKNYNIGCFLQDARFATQAFFIFLMAVMVGRRSVYPPISPNSPLAIVFDHKVNPNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0C9</accession>
    <name>A0A088S0C9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mitochondrial carrier protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_321190</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701805.1">
        <property type="nucleotide sequence ID" value="XM_010703503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0C9"/>
    <dbReference type="GeneID" id="22577860"/>
    <dbReference type="KEGG" id="lpan:LPMP_321190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320017200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_321190"/>
    <dbReference type="eggNOG" id="KOG0764">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="428293at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006862">
        <property type="term" value="P:nucleotide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044712">
        <property type="entry name" value="SLC25A32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45683">
        <property type="entry name" value="MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="11"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="141"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="243"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIO01005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="337" mass="37817" checksum="6EE12767E4F0CAF8" modified="2014-11-26" version="1">MREKKSAPPDATSLQHTVASQLGGATSTILLYPVDVIRTRFISQDGTRTREHNGETYRSIRRAFQLVYREEGGLPAFFRGCHVSVCGTVCAWGVYMYLYRLQCSWYAAWQARRHETHRSRSDLVALSGEDPFAAQSAATWQNLLQRFGFSIIASCTSALACNPIWLLKTRMQLEEASARTAGVPRHFLTFRGGLLHTVQTTGVRSLWRGVSAQIMLGVPNAFNLPLYDTVKAAIMRIRVKNELSVLDVGVSSTVTKVLLALLCQPLVVVKTRLQDHRARAGDVHYQSFLQSTKTIWQRGGLVAFYRGTVSSMCQTVPRSVLLFVFYEQFLKVAKYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0P3</accession>
    <name>A0A088S0P3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_341980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702624.1">
        <property type="nucleotide sequence ID" value="XM_010704322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0P3"/>
    <dbReference type="GeneID" id="22578703"/>
    <dbReference type="KEGG" id="lpan:LPMP_341980"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340026000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_341980"/>
    <dbReference type="eggNOG" id="ENOG502SK8V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271863at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO01824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="509" mass="54536" checksum="C6F33B5531540855" modified="2014-11-26" version="1">MPAFTPSVPPLCPTPSSASSPAVLDDVKLQFVTEEVRRRFSAISMTDMLAVLSKLLTDSRICKCAEEQTGGAVKSDIHSFPLALQLKPTSASTHGGGKAISHLQQQASLSSSTANELNLRDKSTRSFEMNGVPMPNAPAASWLSQEWTTTVTSILENARQDRGPADVHCTVVDKVQLSINEWFANASAETAKSEGLHAAADPAACESPAWLATLTQVRRLAEDTCRSKYEAVYQRLCAEAEDEGDEGMTTPAYALRDDGSAVATSSLMTRQSVHRTATGPVGIPPFSLVIQCGRDGSGTEVTTPPLSIDLDARNSDTCSSTSERNSASFVVGCEWFQWVFLLQSPLACGSGPYPEPEDGGDVEAVAAEQQRWLQRHCAVQLLYPSKAGFSDGSDGSSGLRSAEAEYDLSEPRVVLSSLLGVAMRVWCRRHPHIVAQVRRLEEDTHPWRVHDGSLFWSAWPLRCPGAQGGCGPAAAGGSMPVPLLPGECFAHEPDAEDDDSVVDLLPAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0R8</accession>
    <name>A0A088S0R8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA polymerase II subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_341640</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase epsilon subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702591.1">
        <property type="nucleotide sequence ID" value="XM_010704289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0R8"/>
    <dbReference type="GeneID" id="22578669"/>
    <dbReference type="KEGG" id="lpan:LPMP_341640"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340022300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_341640"/>
    <dbReference type="eggNOG" id="KOG3818">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10254730at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016266">
        <property type="entry name" value="POLE2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="7">
        <location>
            <begin position="277"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO01791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="552" mass="61902" checksum="F17257F63EC67F64" modified="2014-11-26" version="1">MKEPKDEIRSFAQVYKYNLKPLAVDRFAAFLKKYDTGEKYRRDLLRDLFNLIREQCCENRLVDELKADAVISLQEAKIKGCLGAEGSSSVQVVSLDAVPRVFVDEVSNDLRVGSSSTALNRLQCLNQRYALARRRCLRCGLYQKSVDQRALQDGSLVLLPTSALEGLDSNLQIAVLGLLVVRDDEVFLEDLRGKVKLKFSEQSRVTQHCFLGNGFMAVVSGFWVNSFLQVARVDLPPAERREVTLRDVGPSMDLFGLAPQYPMEALREERTRVQSVIIVMAHVHLDKAGTMNKLARFFERMQGLSESDLREVTFVFTGDFSSVPLHFGDASHLPDIFDNSDRMQVLLDGLGRCIAVNAPTAAQYSHFVLIPGPSDMTALQGFQPQTPIAAHFAKGVQSRTKKLTLASNPCRLRFHTHEVIIARRNFLRDFQHGESLYPWDRYRAREHTDAAPNQGAPSGAEAVTTTSFERVTKTVLDEAHLSPSIDEVVLWKVDDALRIPVLPHTMLLCDSTEQWECHYKGVHVVNPGSFAVGGTFLWYTPADGQCSLNKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0X4</accession>
    <name>A0A088S0X4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glycerol kinase</fullName>
            <ecNumber evidence="3">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_342930</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="3"/>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702719.1">
        <property type="nucleotide sequence ID" value="XM_010704417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0X4"/>
    <dbReference type="GeneID" id="22578798"/>
    <dbReference type="KEGG" id="lpan:LPMP_342930"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340035600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_342930"/>
    <dbReference type="eggNOG" id="KOG2517">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5422795at2759"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07792">
        <property type="entry name" value="ASKHA_NBD_FGGY_GK1-3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000086">
        <property type="entry name" value="Glycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000108">
        <property type="entry name" value="Glycerol kinase, glycosomal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042018">
        <property type="entry name" value="GK1-3_metazoan-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000756">
        <property type="entry name" value="PRK00047.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF69">
        <property type="entry name" value="GLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 10 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="11">
        <location>
            <begin position="3"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="12">
        <location>
            <begin position="271"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIO01919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="512" mass="56286" checksum="73B6937515055554" modified="2014-11-26" version="1">MPYVASIDQGTTSSRCIIFDEKFSILSEHQLPHKQITPQPGWLEHDPEEIYRNCCLCLAEAVKKLRAKDPKFDKVSAIGITNQRETGVAWDRQTGKPLCNAIVWSDARTYEVSNRIAKDFGSGDHNFAAHITGLPVSTYFTAFKFRWMLENVPAVAAARKSNMLLLGTIESWLLWKLSEGKVFVTDVSNASRTFLMNLSTQQWCDKLCEKLDIPRTALPAIRSNSERYCDVTANDYGIRDALGVPTPVAGCIGDQQSALFGHMGLHKGDAKNTYGTGCFMLMNVGTEPQFSKNGLLGTIAYKLGTESAKFALEGSIAGAGATMEWMRSNLNFYSHPREIDNIARKVSGTDGVVFVPAFGGLLAPYWDPTARGTLVGMTYKTNKSHIIRAALEAISMQVNAVLLAMKEDSGVEIKCLRVDGGLTRSRLLMEMQADILGVDLYVPHLTETTALGAALCAGLAVGVWKSVKEIQKTAKEQLSGETVSPTMTDKQVRKARLEAWNTAVKRSKWAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S123</accession>
    <name>A0A088S123_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable eukaryotic initiation factor 4A</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">ATP-dependent RNA helicase eIF4A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LPMP_342950</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family. eIF4A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702721.1">
        <property type="nucleotide sequence ID" value="XM_010704419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S123"/>
    <dbReference type="GeneID" id="22578800"/>
    <dbReference type="KEGG" id="lpan:LPMP_342950"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340035800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_342950"/>
    <dbReference type="eggNOG" id="KOG0335">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="417"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="448"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="655"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="811"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="417"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="822"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="855"/>
            <end position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AIO01921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="869" mass="95442" checksum="8A26CD5470417F46" modified="2014-11-26" version="1">MDYISDKKTSDTEYQRYGAVEGDEVSTFRDDRREYSRGGRGRRGGAHRSDNWRFDPSGGGPNGDDSGEYRGGRGGYRGGRGGRGGGRGSRGSYNTWTSRETRDEDNAIPATSDVAGANTPSTTLTPTSAPASALTRVPASPPAETGGVVAPAQESCEAPCEYGNREDDRGYSRGGRGGYRGGGRSYDSGYGGRGGRGGRRYCDPEEEGEEGGYSQNYDSGYGGGGYRRGGYGGRGGRRYYDDEGDYAEGGDRACGRGYEDDDHDDGGSDPYRRSSAPWRRGNYGRDFDYDRPRGRGGRGGRRDFRSFRNENDAMEESGAAQDNAWTSLPAPTEAPTVPRESPPAPAKVEEGVPSPAPQQTQSGIRRVTRASHLRRNCHDEAKVMELFEHRHRQTGISLDNYDSIPVEMVPRDVKPVEDFADLLVEPALAANIERCGYKKPTPVQRYGIPVALAGSDLMACAQTGSGKTAAFLIPVVQYMLVHGVSPARQRKSYPIALVLAPTRELAVQIFDEVRKLTFNTDIFYDVVYGGTRYPQRFEQDILVACPGRLRDMFNEEYLSFSAIKFLILDEADRMLEMGFEEQIEELVASRYTDMPTVDDRQTFMFSATFPQRILNLAKRYLRRKYYLLTVGRVGSTTKNITQTIEHVPDNEKMDRLLQIIYGHEMSDMVLIFVETKKMAEDVNRRLHREGISSTTIHGDRRQQDREAALEDFKQKVTPILVATDVASRGLDIPDVAHVVQFDLPQEMDDYTHRIGRTGRAGNKGIATAFYNRNNRRLALDLHKYFSEHGQEIPKWFQQEAELVEGEALLSRDIGGGGRRRGGGGGGGGHRSGGSGGRGGGGGGGSWGDSRPSAPSGGGRRGCGMDDGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S168</accession>
    <name>A0A088S168_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_324090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702090.1">
        <property type="nucleotide sequence ID" value="XM_010703788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S168"/>
    <dbReference type="GeneID" id="22578150"/>
    <dbReference type="KEGG" id="lpan:LPMP_324090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320048200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_324090"/>
    <dbReference type="eggNOG" id="ENOG502RYJ1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269275at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO01290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="185" mass="21766" checksum="E8ACB8967295CC5C" modified="2014-11-26" version="1">MLRQVCLRKAPKVELISPTPSAPIQNFDLQPIAASLLYRRLLKLYLRKFDTDTNTIVRAWKQTKYEFWVHRNASKEEADLLNIKGQQVLEAIRAGLVPVYHNSKTNQIYYKYDADTLKAVHNHIDPVSAEEFLRRFHDRMDSRDVEEIQATLKKLGRWTGPDELRKEDLFRVKTKRKVKCTDPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1I4</accession>
    <name>A0A088S1I4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">40S ribosomal protein S18, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_350960</name>
        <name evidence="8" type="ORF">LPMP_350970</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703033.1">
        <property type="nucleotide sequence ID" value="XM_010704731.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703034.1">
        <property type="nucleotide sequence ID" value="XM_010704732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1I4"/>
    <dbReference type="GeneID" id="22579125"/>
    <dbReference type="GeneID" id="22579126"/>
    <dbReference type="KEGG" id="lpan:LPMP_350960"/>
    <dbReference type="KEGG" id="lpan:LPMP_350970"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350015400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_350960"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_350970"/>
    <dbReference type="eggNOG" id="KOG3311">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="256189at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.50:FF:000002">
        <property type="entry name" value="40S ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.910.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="entry name" value="30s ribosomal protein s13, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_uS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="Rbsml_uS13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_uS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_uS13_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003140">
        <property type="entry name" value="PRK04053.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO02233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO02234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="153" mass="17452" checksum="5B2AADD60E966B5F" modified="2014-11-26" version="1">MSLTLIPDHFQHIVRLLNTNVEGKRKVPFALRMVKGVGIRFAYLVCKKTGIDVERRAGTLTAEELEKVAEVIVDPARFKIPDWFLNRQRDPKTGKTEHLSSSMVDTRLRDDLERLKKMRAHRGVRHAYGLRVRGQHTCTSGRHGKTVGVSRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1L2</accession>
    <name>A0A088S1L2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_351300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703068.1">
        <property type="nucleotide sequence ID" value="XM_010704766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1L2"/>
    <dbReference type="GeneID" id="22579159"/>
    <dbReference type="KEGG" id="lpan:LPMP_351300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350018600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_351300"/>
    <dbReference type="eggNOG" id="ENOG502S96W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272133at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039963">
        <property type="entry name" value="Unchar_22kDa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38828">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38828:SF4">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO02268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="190" mass="22138" checksum="2AC4B5B2263B3E24" modified="2014-11-26" version="1">MADTYESLATEKRLTPEELDRQVERLTAPRRAVELRDPFEVCPTKRISAEALSKMTDRLYTQSLQHKQELLAAAEQVAYGVHTRGTALSGSPLTPEDQEQSVKRMFHDTLERKRRNMEQLRRQYRYHSPADKTKVPLKTFVQHMYYDRLEAEKKTEKYLYDTYLAPTAIHTGTISRVQADETSNRLCTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1Q1</accession>
    <name>A0A088S1Q1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MORN repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_351860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703123.1">
        <property type="nucleotide sequence ID" value="XM_010704821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1Q1"/>
    <dbReference type="GeneID" id="22579215"/>
    <dbReference type="KEGG" id="lpan:LPMP_351860"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350024600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_351860"/>
    <dbReference type="eggNOG" id="KOG0229">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270720at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.110.10:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 4-phosphate 5-kinase 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23084:SF263">
        <property type="entry name" value="MORN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23084">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="344"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="649"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO02323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="941" mass="101044" checksum="1C9197C29204D0FD" modified="2014-11-26" version="1">MLTTTVFPVASSPRSHSMSTSIPLGSQSTKIDPSNPFPADGKVGAQHPVSYFTVALTQPVLVVIRMTESSTASRCALFLSCSCPKPDANNAAWRLISPEPVKQIVLHPADPSYRADMLHIAVHYLEPSGQSHFQLRVRVQSEFFAMWLRTGEGTRAATGAAAGDYVTSVKKVRSAGVSASGKVTAADAAAVLAVPMLRTMLAAPVAQTSGTIATSTGVPFTSLYVGDWRGDQRSGLGFQYYAAPEVMVSQMTLTGGYVKDFEHSSASNNNSSDRDATCTFTSQPAAVAAGVPVAQPLMLLRAFSERHNLPWSAWSIPDTLTPEELARMGFGFCFPSASRMRDDNVGTGLTSDRAAVPSKGPTASSPTGSSSGAGAAALPTTSPTPPVAPYPTAAEGIAALGTAIDAFVVAEIMSGEVDAWQVLPVQPGVEVYAGQWVANRKEGKGAYQWSDRSYVGEWVGGRREGYGLLRRQDGRWYRGQWERHVPHGRGEACLTPGGLLYKGEWRDGRRHGLGALTYPNGMTVHGMWVGDEMHPRVHVMYHDGGTYDGLWDPEKACRQGQGTWTDTQGCKHTYEWQSDIRVGAGQEAYPNGVLMHGVWQAGELVESTYVFPNGDRHVGSLDAILHIREGVGTTVSADGASAYTGAWHQDKRSGHGMQTVQKPPRACKSSEPTASPCVERYEGEWFNDVRSGQGRLTDGDDIYEGQFALNCRDGVGVQHNTRTGSFYQGNWKANRRCGAGTYYSATQGMTYEGIFMHDRLTGLGTATNTAFAEQYTGSWLDGLQHGHGSLRLANGDVLRGVWHRGVPEATATVEYVEAALLADGPHRAEAAVPRYVGGWQDGVREGTGTQVFRDGSVYEGMWHANKQHGHGRRTTASGESVECEWRGGCILDGCVGVARFADGSVYHGHVNVAGVPHGAGVLTYADSTVFDGQFLDGIYQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S213</accession>
    <name>A0A088S213_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Vesicle transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_050790</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the SFT2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="AIN95521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703843.1">
        <property type="nucleotide sequence ID" value="XM_010705541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S213"/>
    <dbReference type="GeneID" id="22572157"/>
    <dbReference type="KEGG" id="lpan:LPMP_050790"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_050012600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_050790"/>
    <dbReference type="eggNOG" id="KOG2887">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="73614at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011691">
        <property type="entry name" value="Vesicle_transpt_SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137:SF6">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN95521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="163" mass="17627" checksum="70118756A4AF3B95" modified="2014-11-26" version="1">MDKVTSIISVATSGGLDGAAGTDNQESLCPSLTFKQRVQGCLGCAGIGLLFFILSWVTVFLGDYVSFGFLFTLGNLMCLGSTFFLAGPVRQFKSMFDEGRWIASTVYLITMVLTILCVVLVHSGLLTLLSSILQLMALVWYILSYIPFARDVVKGALSSLTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2D9</accession>
    <name>A0A088S2D9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Proteasome activator protein pa26, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_340680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702495.1">
        <property type="nucleotide sequence ID" value="XM_010704193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2D9"/>
    <dbReference type="GeneID" id="22578572"/>
    <dbReference type="KEGG" id="lpan:LPMP_340680"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340012200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_340680"/>
    <dbReference type="eggNOG" id="ENOG502S0TE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="244716at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008537">
        <property type="term" value="C:proteasome activator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.180">
        <property type="entry name" value="Proteasome activator pa28, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003186">
        <property type="entry name" value="PA28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036997">
        <property type="entry name" value="PA28_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036252">
        <property type="entry name" value="Proteasome_activ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02252">
        <property type="entry name" value="PA28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47216">
        <property type="entry name" value="Proteasome activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome activator PA28 C-terminal" evidence="1">
        <location>
            <begin position="60"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="222" mass="24084" checksum="4B58C4155B218F70" modified="2014-11-26" version="1">MAQAIRDTYSEEASFAIVEEWSSKVLADLEARATNAHHARQGVLAKPYTADAAETVPVSVVASLREFQGELHDIYRGAETIRTVIACRIPELKSEDNLGVEVQMAVLKMVDSLEGKLLGSGGDKDGGVPCVAGMYATRDYLTARGSVEDKVLGKAGDDDKKTKSAAPSVLMELQQIDADALLKLELSAMQISTQIRSFINVYALNWKKLIQPRSNGSEKNIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2I6</accession>
    <name>A0A088S2I6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_354820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703413.1">
        <property type="nucleotide sequence ID" value="XM_010705111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2I6"/>
    <dbReference type="GeneID" id="22579510"/>
    <dbReference type="KEGG" id="lpan:LPMP_354820"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350056400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_354820"/>
    <dbReference type="eggNOG" id="ENOG502SGY6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="555"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="612"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1021" mass="110243" checksum="D18171EAFEF88470" modified="2014-11-26" version="1">MNIQISGNLSKPTVVFIAGWPDTCDIFRDNVMATLAADYRIVGVTLPGFDDEHPFLAQLRKRDSAATRNESKRMWRHREEVSTRFVATASTGASTNLPFRFLTSVGAAPRSHSGSKISGGACVSTPLQSFGLPSCCATLEPFRTSWKGHSFEDLVTLLEIAVDTAMETCNYCPPVVLPTSAEAQDSPSCSSSSSSSETETSDSSTAAFAPHQLPPKYTRPVIIAHDWGCLLAYELLLARPGLFSRIVALDVGAYLFESEAAHVERMCALVSAQDKGRPTEIAGNSFAAAQAKVSLETEKAVKFSTPGQEDNAIPQITVNRDSHVVQDGLRVPSGGPTPTITLLRRQSSSPPETLSSLVTIPHNVAPGGQLKAQRALSPLSQMRTDPPSLGTKRSLALQYAFRRRKGTALPQRAETRKMLLIVLYQFFLITCELFVPHRLARWLLGLLSSLFGRPSYTYDPQMVVTPTMELLNHTLNAQFFARHPFAIENRGALQVPMLLQTREPGSPSSNAAAAAAASLEASYGKNKGPVQPTTAGWKVMLIPYVEKTCVKAFPGRARSGNQDQLAGKGRRTASSRRSLYEDGVGMAFDGSFRMIHKSTHCGRIRRYSVEESSATDSSASADGTSDASGGNSSANQSFSAWEENTPADGAHVVFSSYAKGAHMVSDEWNSLTTGTRGIFGGSHGGRGNSGEFDPYTSVNGITAPVWDTDDPLTLTGAQSFMETNRVAGVNSKDAVHLLATDGTLASGGGRADIVGVSSNPGSRQMHVAKRRLFYQAFVFPPLNHDVAGPSSSSFHSDLDDGASGRSSGDARAAALCRLCKPNRAASQHPAVLVRASPWQSWIYLRFWLGRLLLHFVALVSWLLGEQYSTQPSAVPGDGTAVGTASSVSGKVSSNVMTTAMTTIYRRLPATPSLAADVSTLPGNGDVVLQPKSYAPLVTQRYFVPLPIPILFMYGGEKRIMFHADHWCSYIRHYQRPRDGISDVVEVQGGGHWFFAEKKYQKKVADRIAEFLAAEPKTSYVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2J4</accession>
    <name>A0A088S2J4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phosphatidylinositol N-acetylglucosaminyltransferase, subunit P, putative</fullName>
            <ecNumber evidence="7">2.4.1.198</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_354870</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.198" evidence="7"/>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703418.1">
        <property type="nucleotide sequence ID" value="XM_010705116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2J4"/>
    <dbReference type="GeneID" id="22579515"/>
    <dbReference type="KEGG" id="lpan:LPMP_354870"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350057100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_354870"/>
    <dbReference type="eggNOG" id="KOG2257">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="690928at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017176">
        <property type="term" value="F:phosphatidylinositol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052263">
        <property type="entry name" value="GPI_Anchor_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013717">
        <property type="entry name" value="PIG-P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46346">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46346:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08510">
        <property type="entry name" value="PIG-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="PIG-P" evidence="6">
        <location>
            <begin position="86"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO02618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="210" mass="23741" checksum="E351F29C4DA85A4F" modified="2014-11-26" version="1">MYSSIPRHPVAYTAAVVFFSHCLFFRLTSFLRFLLLPFAPHSPLPQYRGKTSDQQKNLYCSFLLFASHSSTPFSSLMREDSQRAQVAINGFIGSILIVVGSIVYVLWSVLPDEVLHRMHMTYYPDRYWAVAVPAILVMFLVHYFTTSWLLVLVTTHPLTDGRCITDEDSKPDTEIEVGALADSGSSLPPWVDIPVSVASHLLFEPWNKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2P7</accession>
    <name>A0A088S2P7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Importin 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_342190</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702645.1">
        <property type="nucleotide sequence ID" value="XM_010704343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2P7"/>
    <dbReference type="GeneID" id="22578724"/>
    <dbReference type="KEGG" id="lpan:LPMP_342190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340027900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_342190"/>
    <dbReference type="eggNOG" id="KOG2023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="951172at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="350"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="365"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO01845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="919" mass="99948" checksum="A2C02FCB78EE0968" modified="2014-11-26" version="1">MTSLAPQILAALASASSPVTERRQEGDAQLQQLKLNATVYFSSCAEIFVSQQADLRGRQLVGFQLKNSLADPACAQNAQLQLAVCEHAVADPQRIIRNVAGSIISVAVREGLWPAEPVVRQLGTILTQRSNELGAVHGAIRALSYIVDDAVSLLDVAGLTKPVLLAALPYLTSTAFGTTGADALEIRVKAFEVVALILEHAGMDFESSSYQSLQGGIIGVVQACFDNLKAPLSQAIATQCIRCLALSLTFYRDIDDDLFEQIGQLMYQATTAGNGAAPANAEEESLRIEATEFWRAILHFPHFAQVAQSTVVQIIPVIIKSMIYSEMEIGMLQASAEDWQVPDKIDSIRPRHYKEHSKTTGGGGDDQEEDDGDDDDEVEEWNLRRVSALTLDELSQYYGDLVLLPVLSCVEGMIRSGPANWRQQEAGVLAIGAFCEGCYDSLEQFLPDICPMLLQLLEAADTHFLVVSISLWSCTRLGSYFLSSDSLMGRLMACILRKMENPSKMVQGAAVEALRSMLEMAEEGKVDVATPAIVRTIATCFGAYQLKNRVLLLEAVQSVCQTLGTAVRSSEELISTLLAPLGQLWSQTLNDSPLLWSLFDCMATVCSTLGPAMQPMTAEIFNRSFSLLREHLQHRHAALQSGDIPPDEEFIVTSSILLSGLFDAMGSGLEPLVAQNEPVFMQLTLSMLSDASPHIRQNGFCLASDVARTCPMHLQQVLPQFCDLAVQNVTLADESCYAVVSNVAWAVCNLLEHQVDGTGAPTMQASPAMPHLFGLFAKLLGQTNITSDMRNMAENVLLCLGVMLYVDADVESKAGCSVELFAGAFCRFVRNVRESSSLLEAGTNGFLTAIQQKPSIVLTNLVLFCDLGCSVAVEGIEASRMIRDLLSNALRANPNAWRQALGSCTEPTRKKLYERYGFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2U8</accession>
    <name>A0A088S2U8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_354060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703341.1">
        <property type="nucleotide sequence ID" value="XM_010705039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2U8"/>
    <dbReference type="GeneID" id="22579434"/>
    <dbReference type="KEGG" id="lpan:LPMP_354060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350048600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_354060"/>
    <dbReference type="eggNOG" id="ENOG502SIBS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266361at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="934"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="942"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="963"/>
            <end position="984"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1017" mass="107098" checksum="4265324F833020C6" modified="2014-11-26" version="1">MPRNLYRIPVKQQSNMSAASKATPAPVDDAREENHELASLPSTSVLPIRAKHRGRGRPRTYPSNTSSAHSLHPHLALAEPGSGDHEETPTATALVPAVSNLTSTAAAIVDSATAMNHLEVIEGAETFGAAAAASAELLLQMPLAPLPGSFSSSGTIKAQSLVTTTPVDTVQGEQEAGTISSLPPSHSTTRGVATVPASMAAEKVDCATLGAQPLLPSMAACMAACFGWRLKRCCVGEGAQIMFALQHRTVPVVHVTIESTRGSFMQECGVSGETDDSAIRVNGTLMSLTQCAAYLQELTHALFTLSDISHCGPPTDHVPAEEQRNNEVIGDGGLVPSSTAPTPHLFTPNAEAKFAERRGKKRTRSRSSLPGAHSTASVLRTAELVSGATVLSLAEASATVERGDAEASKEESKPYLLPLKSSNVTLPPAPLTTPLPASLAATDVKVKTEPSLLETSPRISESENDGDTQSLSALAALVAAMECGEPSTSLPRAPPALRTNAGKFSAPPKRDLSSTNKGTASREPRASSTVFAFPTMRQRRTLVFPHIACAAAGLASAITGAHHVPPASPTPPHVALGTATFTMPFAFHHASAAPLSASATPEELDMVSCTNDSKGGYRSVWCDSAGWSTDSSRLWLAHTHAVSRAFACMPVPCYSVPATMKVSEPLGGEGANEQRTSTAASASSLVPLMGSAAAAAFVRMTLRWRWRKRSSMGTAMEDSLRMAIGSGHLRGDALEAGVQALQASEAEQHRYNGVDVDVGEDGSDLGPLCRRTAPDVGQVGHGAVQQQTLSFPACPPRALLPVSGRAIVEAQHRIAEAEEEKGGEEAAQGPRYVACAGGIPFADRIVIDHTYSTRGSYVMAPPVMAEGATATPCRRLMLQRNPQEDLHYHVYKRVMPTDMRLAVEAEETLTIGSGNIAPPPVVDDELSPTYNLRRRFGRGAGDDNEDDEERDDRGDDADEGKAYDSSSASRAAPRAPGATAVADARGGVLSTDIDYVLRYRPSIRRIPMPDVESRYGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S319</accession>
    <name>A0A088S319_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Homocysteine S-methyltransferase, putative</fullName>
            <ecNumber evidence="7">2.1.1.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_356450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="2.1.1.10" evidence="7"/>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703573.1">
        <property type="nucleotide sequence ID" value="XM_010705271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S319"/>
    <dbReference type="GeneID" id="22579673"/>
    <dbReference type="KEGG" id="lpan:LPMP_356450"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350073200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_356450"/>
    <dbReference type="eggNOG" id="KOG1579">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="261426at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008898">
        <property type="term" value="F:S-adenosylmethionine-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033528">
        <property type="term" value="P:S-methylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.330:FF:000002">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="entry name" value="Homocysteine-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017226">
        <property type="entry name" value="BHMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051486">
        <property type="entry name" value="Hcy_S-methyltransferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007020">
        <property type="entry name" value="PRK09485.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015:SF1">
        <property type="entry name" value="HOMOCYSTEINE S-METHYLTRANSFERASE-LIKE ISOFORM 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015">
        <property type="entry name" value="ZGC:172121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037505">
        <property type="entry name" value="Betaine_HMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="6">
        <location>
            <begin position="1"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO02773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="320" mass="34329" checksum="2B53FECDF2BF7ED3" modified="2014-11-26" version="1">MEAYLADPKHVVVLDGGLGTELEARGCNLLDPLWSGEVLLKSPQKIQDVELAYLQAGARCLITASYQITPKSLMEHRLLTEEAAAAVIEESVRIAQVVRERHVKENPQAEPVFVAGSVGPYGAYLADGSEYRGDYVRSAEKFKEFHRARIAALLRAGVDVLAIETQASAAEVHAIVALLQEEHPNCRAWVSFTTSRTSPVKAISDGTTWADIIPFLEMSPQVVAVGVNCIPMAEASAVLAHLHTLTTMPLVVYTNSGESYNPATKTWHPIAKADGTTLSLAALAPEWASQGARIIGGCCRTRPSDIAGAAAALRSACFIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S377</accession>
    <name>A0A088S377_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G10 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_090250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BUD31 (G10) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN95941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704263.1">
        <property type="nucleotide sequence ID" value="XM_010705961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S377"/>
    <dbReference type="GeneID" id="22572595"/>
    <dbReference type="KEGG" id="lpan:LPMP_090250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090007500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_090250"/>
    <dbReference type="eggNOG" id="KOG3404">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277109at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001748">
        <property type="entry name" value="BUD31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411:SF0">
        <property type="entry name" value="PROTEIN BUD31 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411">
        <property type="entry name" value="PROTEIN BUD31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01125">
        <property type="entry name" value="BUD31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="31"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="247"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN95941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="29549" checksum="ADB8F679B42F95AE" modified="2014-11-26" version="1">MPLIRPGMPKPPHGFDAVLAKLEKYDEQMKLATQEESKGVIGVTTRPRHDGRSSGSGARKRTRDGNDNANNGAMALPAEASSAIAAVESEVDSYIVGEEKVEAKGGAPVPPLWHMAAINRARTRYVFLAYYKQHSISKEVYDYCVEMRLIDGGLARRWRLPGYERLCCTACGVPGAASLAASITSKYALRDRQERRLSTSASQQRIDDTATCICRVPAAQRKNKYFVACAVCGCRGCCSADAVKVTTERGDGDGKTDRTREEPLTDAPSGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S413</accession>
    <name>A0A088S413_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_100960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696819.1">
        <property type="nucleotide sequence ID" value="XM_010698517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S413"/>
    <dbReference type="GeneID" id="22572833"/>
    <dbReference type="KEGG" id="lpan:LPMP_100960"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100016400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_100960"/>
    <dbReference type="eggNOG" id="ENOG502SBG7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273872at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="322" mass="33523" checksum="581370BBA15FDF80" modified="2014-11-26" version="1">MKFHLHVVDGNALASSGAAPNSSLPTATQATAVMLFAHMTLRCGHLSDVLVVSASTTPALARAAELQPQQNELRSGAAQLSNADASVSEDTHVLQMAGKVLSGALDRGAAVDLPYMDNDGGDARIAPYAYFNSSFSEAELSLRRAVCVLAESGTAALPPYFDLIATTDLVTFDYIVEYYQQQRVRHGGAVTKGRGTKPVGVVHIVADDPSRAALVLQRVVELMLKRSGWTFSVDAHTAEEEEKALAAQTDEDEDEDGDDENGGSGGGSTAGGRGGVVSAGTGGGSVQPGARSGSADSWVNHIDEAVHLFAQLFGVDVLVTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S489</accession>
    <name>A0A088S489_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sister chromatid cohesion protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_110870</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696934.1">
        <property type="nucleotide sequence ID" value="XM_010698632.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22572952"/>
    <dbReference type="KEGG" id="lpan:LPMP_110870"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_110012100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_110870"/>
    <dbReference type="eggNOG" id="ENOG502QTB5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="200660at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039776">
        <property type="entry name" value="Pds5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663">
        <property type="entry name" value="ANDROGEN INDUCED INHIBITOR OF PROLIFERATION AS3 / PDS5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663:SF0">
        <property type="entry name" value="PRECOCIOUS DISSOCIATION OF SISTERS 5, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20168">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="331"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="548"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1545"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1588"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1642"/>
            <end position="1661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="338"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="561"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1549"/>
            <end position="1564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1643"/>
            <end position="1661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN96281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1768" mass="187938" checksum="6F3530EABD771BFF" modified="2014-11-26" version="1">MSACDSVRGLSLVEPSTTPRLNSTPFSATYIEELLTPRLLSSPIPDVSQLVGCLLCDAVRLHHEEQRQQRQQRHRGESTLTYASSGSSGSVINTQVDATLDVLETAGGESLPFPEVRCVDVLHCICACFSRLQLAPLNASPSSAVPQRQSLQRVAYLVERAATSHIFCHLLPHCSLASEEVQQALLYVFQAVCCASSATASEMGDCTRSDTSTSAATCAEMAQVLCDLLWFTRIVTPAQLMPLLDELVTASPTLQLTSPSASSLSSLSACVSGARQNRHHLARCGSGGALITARLLVDQMDVLRPAIATWAMGEFEEGLAEVLGSDMLQSDGEDLEGEERGNRSDTDEDGPHPQRLQQPRGKIAKLPQEAQLTRKRRGLRVLARVLEVLVALMELHVDLADPLLLSLAPHLEHTCPEVRLLLLRGFSAVFAANEAAVRTYRAAFVGPFLSRFLDVKPNIRMDAVRLSTVLLQRYGDSTRPGAGHAGRHTNDSSADPSRAQSLQQDLWQAFQPFWERLLTDPHVLVRKQAVASVAEAALVAPLLLQPSPQRDNVDDGGLRGGQQTAPSSTHSPSNFLAHTLGLRALDKNRRVRGAAVEWLTRLYSEYRLVWIPNAVLDAVRVDTGSSSPTAPVLLTAETVVDGLLSAPLSCLLPSSATCTASATQATLTRWLSPTSPAVLPPTKTPALLDFEGSSIEETQVSQQRPSGGGGFEEGDALLGFGESASSTKDAGGRGVLAAKSTPSAAAAAAVSAYVDALVQLCQHVDAAHFAQLLRLSEKKPQLRLAIRRLFEFQSAVKESNGDVKSAEGQQRIHSIHRLLTFLQETTGASKGEWDVLFRAKDETVRRALLRACDVAHMDWVEVREGLLRSLHGRIGADEFAFVKQTLIPQMFFVVQPSHLAELMRRLHISIYTSARDKAEVDGASAAGALRALLLLTAASPSFAVLCTKGLAEALQAAAKQSIGPPPNWCALLLQALQKWATAAATMADTSATAIAGAASLHDSLIATLRAMALASLPMQQTIPPSLASTAVTPGTNSCHSGMALSALKQLAKQATRTLVALLRVPGCDTSAATALYSLASELAKCLASGRALTNNVEAVAWLASVRALSRCSGGNGSDDRISPVDAALVLLQVSTTPTTTVAAAEPIPALLLSLSSLLIDAVEDVSGKAGRARLRALATPSATGVDSAEAATGRAHSVLCHSPLSTNMSVAAAIVDGSAKAMVTLALSCPKSSDAGNSGSSNNVASRANAVKYALGVLLEGYKASATVAPGRRGPDSIGSCQCRVALEKQLVKLVLTPTPVISRELAVSVVLSVEENAHVRHAVQAKLAGHLLHRTCDMRVAALLLLTAISEDSKSSYQRLRGLVETVGDHLRAKQSSQGASLSSPSALYCYWEYTIPFLILFLAHHPYYSSEEAGNQFIGFQRVWHLLIGELLRHGTQCAGFVVELLSKIKQADDALDPASDACRVMCDLASRVLLECLGQRQSRAEDLRRYPGAVLLPSFFVPTSRASPHKLLETVFLDDSVRVTANAPFRVPAVGGTAMGAGIGSRGSSRQATPRASSTALSGGADETTEVKYVTSAAAPYGAGTADTAVPPSTLRKRTRSPKTGVSTAVVSLSPSVGSPCEDDVVAKKEGIIPQRECAEPAVAESSSSSGPLSGSAIASQEWKTKRAALQHLTIEEALDNLFRGLTKADIAQLRWKVVRSHIEEALRALDCGQLPHQQLSSIADAGTGADLVMIKGAWTSESDMEDLLQYTKDQLRVRYDRAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S560</accession>
    <name>A0A088S560_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_356720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703600.1">
        <property type="nucleotide sequence ID" value="XM_010705298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S560"/>
    <dbReference type="GeneID" id="22579700"/>
    <dbReference type="KEGG" id="lpan:LPMP_356720"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350076800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_356720"/>
    <dbReference type="eggNOG" id="KOG2009">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272624at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001156">
        <property type="term" value="F:TFIIIC-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070898">
        <property type="term" value="P:RNA polymerase III preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039467">
        <property type="entry name" value="TFIIIB_B''_Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929:SF0">
        <property type="entry name" value="TRANSCRIPTION FACTOR TFIIIB COMPONENT B'' HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15963">
        <property type="entry name" value="Myb_DNA-bind_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="176"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO02800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="394" mass="43634" checksum="D065D0F134B28BC0" modified="2014-11-26" version="1">MDDNEFEFPPDQLDDVIAKRLSPYQTAMPNPLQTSFAYSVDNVPLNMLAQIPLEHLPPTLPKNPQNFSIGQVLRGALSTSHMRAPPGGSGISRPGASVAPLPHSQRLHQHSPTHSPYLLAGPPPHHSATSDEEERDGGAEDAFQLGKEGIAEAHGGNALDSTELQMRVRRPSNRQARIDWSEAEVRSFYQALSQYGTDFSAIAVLFPGRTRRDIKRLYQREMRQKPKEVQTALSQKHPIDMAAFEVRYEAKKKEAQQLVKTKKLNAEELAFLDEIAGGQPSESAVPVKSEELEAPVPAATLGDVEETTAAPPSRPHKRRRETHDMEAKDGLEAKPATNDTAPAADDDFDMVQESLFDMVMHREFEDKVSLDILFAAQLHQGQQQAALEDSEFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S5D3</accession>
    <name>A0A088S5D3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_141130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697344.1">
        <property type="nucleotide sequence ID" value="XM_010699042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S5D3"/>
    <dbReference type="GeneID" id="22573380"/>
    <dbReference type="KEGG" id="lpan:LPMP_141130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140016900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_141130"/>
    <dbReference type="eggNOG" id="ENOG502S6GB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273635at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="312" mass="34270" checksum="7326E219ACC587A6" modified="2014-11-26" version="1">MRQLGGSALLARYCTRRVGPCCSGSICSSRGIASTATVSPSTSNGAEAAAASAARLARAAQIRRRELLFQWMRRLVVPAFSIYGLFLLRPTEGHFLRYVAERRHLDTTFNAWFPPVAVGSPANSGSKKALAAREQTPASVSSLTGRTDAKGGASSLLPEAAATAFRSERDREWASKRFHYKKGSEDEERVASRCLLFARDRVHLPDDTVVETIRSRSEQLEEIRALREHPPMHLLSEQLNTIAEESHRYAAALAAAVVQPAAAVSMPPQVEIQFEDRTLFATAAIVFRDRDGRVVRAMRFIGACGMIWKEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S5E1</accession>
    <name>A0A088S5E1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_141230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697354.1">
        <property type="nucleotide sequence ID" value="XM_010699052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S5E1"/>
    <dbReference type="GeneID" id="22573390"/>
    <dbReference type="KEGG" id="lpan:LPMP_141230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140017900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_141230"/>
    <dbReference type="eggNOG" id="ENOG502SJVV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="260148at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839293" evidence="1">
        <location>
            <begin position="39"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="206" mass="22126" checksum="B027FBEF25A46C1F" modified="2014-11-26" version="1">MTSSSTNSPRRPAPLALGVAVLVAALVLLSVCGVPAQAATVTDLKNAVNVMLQDIDVGMTDFYRTLSAPPAVQQQYCTAAISSVVEGLSLTMESLSSPYGVLATEHGFLVYKDSFVFGPSVSLIGASAWPNGTLTTKVQHGKNILLPFLSNTIVFVTGVVTNDKGRKNILPMARFMIVDAYRCTYLHMDVSELYRNTFRTVFAELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S5Y7</accession>
    <name>A0A088S5Y7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallopeptidase, putative</fullName>
            <ecNumber evidence="3">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_160820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN96956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697609.1">
        <property type="nucleotide sequence ID" value="XM_010699307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S5Y7"/>
    <dbReference type="GeneID" id="22573660"/>
    <dbReference type="KEGG" id="lpan:LPMP_160820"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160012400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_160820"/>
    <dbReference type="eggNOG" id="KOG1554">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="605656at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000112">
        <property type="entry name" value="Mov34/MPN/PAD-1 metallopeptidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="2">
        <location>
            <begin position="70"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="473" mass="51343" checksum="C0B385D96C3D17CB" modified="2014-11-26" version="1">MSARVANSVQQSPGHSHGGLSTPVSGGPQHKLYRSVPIVSDAYWAPDFAHMEAARRQKPWHIDSLFFESVSVSLVATVKMFLHGTRGRPDMSQGRFNWFEVMGLLIGHFNHRELILTDSFSLPVAASEVECSMTEASQIYMANYLEYHRRLGKAEPGCIGWYHTHPGYSCFLSGIDVTTQQGSQRMQDPWVALVIDPVKTLRSGEFSMKAFRTYPEGNLQDQCSQNGSHNAAEGAHPAASSANASASLVYEGYGLPSVSRLKEFGMHAHKYYELPVRIVQSARDAPLWELLQRHFWPLSLSLTFPFAPSTQICLCSSAELAKVVSALAARTQGPYAHERSPLARGRFSRRGDVESMPLLYQSSKGVRSAQACSGGDGSADAGDAAKLGQRLLAITSDVLSARAESFSLIGASRPVHAELRAAMRAVAAATGSLARGKRHSCTSPGSARNAQKEVSLSSSPTSSHDDSMEEEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S7D8</accession>
    <name>A0A088S7D8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Potassium voltage-gated channel, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_191500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698144.1">
        <property type="nucleotide sequence ID" value="XM_010699842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S7D8"/>
    <dbReference type="GeneID" id="22574204"/>
    <dbReference type="KEGG" id="lpan:LPMP_191500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190022600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_191500"/>
    <dbReference type="eggNOG" id="ENOG502RE7G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2414723at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18316">
        <property type="entry name" value="BTB_POZ_KCTD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499:SF131">
        <property type="entry name" value="VOLTAGE-GATED CHANNEL, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="38"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="343" mass="39105" checksum="7CE7FD15AA87F726" modified="2014-11-26" version="1">MSFDRRWAWQHARPMSSMCEHQECARVHRPQERTHMNRIIKVNVGGRYFQTRLSTLLRFPDTSFAKMFEGLASTSIAPSTPSPSPEVTENEDVFVDANPDVFEKVLGFLRTNHIQLPLNDEGLRAELVHHLKYWDLMPHAFPASAVDGAVEGEEAHLIELPDVCVVQVCDHMQHDQGVKRHAMTITYGADGFQLRKLAQMIRRDLNQQLSSTYWQCYQTNERAAFFATTKVANGAADILTTSITQQVVQHTERLGYHLATSYVTLSPDVVHTSVRMLIHNFIFRRVRLPALEAADEAALLGDEGDEVETYQNFEPRPVGPQKVQWEDSPSRPPRQEVSSDLWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S7P6</accession>
    <name>A0A088S7P6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_201170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698318.1">
        <property type="nucleotide sequence ID" value="XM_010700016.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22574326"/>
    <dbReference type="KEGG" id="lpan:LPMP_201170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200016900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201170"/>
    <dbReference type="eggNOG" id="ENOG502SM1A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267425at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
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        <location>
            <begin position="1"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="711"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="852"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1017"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1571"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1618"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1696"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1768"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1901"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="2058"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        <location>
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        <location>
            <begin position="11"/>
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            <begin position="64"/>
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            <begin position="1855"/>
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            <begin position="1980"/>
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            <begin position="1996"/>
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        </location>
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            <begin position="2096"/>
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            <begin position="2170"/>
            <end position="2180"/>
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            <begin position="2323"/>
            <end position="2332"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="EMBL" id="AIN97611.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2391" mass="258885" checksum="2DEE072986D08883" modified="2014-11-26" version="1">MRAVPPQQPKPSSRPVSARSPSSASADAWKASMGDELLHGKPLQQDSPDVAAAVPREDLNSTLEEAEGDIDVDYADEGSAQSREVSGSNDGATHPQHRFPVMMPESSLATIAVPPIPTMSPITGPTSPMSLSSSIATDTPRSILRQSGSASGRTPQSSSRRISFVGVSPPRLDEPHDRRHGKEENEDDSDDYESAEPSLRYDIVTLTTPVNGTPPRHARSARSLDSSSPNSDYHSQECNEDPSRRASSPVPAPQQQWASSSLSPERPRLSSRSRTHSPPRGSGGGYTSRTGLPLSTPVAVPSAPPSPEEEGDEITLDVAPQHRVPALQHLTQGPDRRIDQRRARSPSMETIGHDDDVLTQPHNRSETEGVADVAAVVRRPPPRQRWPSDAYQDDPPTEVSIQQRGRKSRRERLDPEDDMDSSSSSQRSNDNDSLSTDSDDSLSARYASPLKAHQEEQRGLSHLPTSSSPPVPAFSAHKTRAGSPTPRRHSANSTENSDRTSSSSRGSTLNQRRTSRVPSSATPRPPLQTQQDNTYEPNLGNSSHEHNHGRSSKAVTSAFLSTSHNRSCGMLVGEENRGQDNHANSGAPPPYRETSLFSSTGYSPSTITGHSSDRSVAGDLSGFATAAAAPEPRRMPLRTRRKHHGYTDTSATVLKNYQQQHEIIPSVLSAVTTTEKSKQTKDRQAAGVVEGDVSQVYVDPLLRERRHRHELARQESLPHEEQHSPSANARSTSSHVEQPHRRHSRLHARRRSPCSERAANHQPATYESVSLRDIMMRHDSPTTKSRRGTSFGQSTTGVILHPHSEVRQLHLQRSSHDNDGAAAMEASVKSSSLLSSGGVPADELLWDTSTLASHARSSPPPSVSSRFSSERVLNTPGGRKVLRKKLVVVVRRKKTGAVPSENDPVMQMSLLPFKEGAAALLESNSLLQGSPQQQRRARSASLPAAAATPVLEKLIDHMGQSRCTSVSSRFPSRVSQRQCWSSSEAAHKCDGGDYHAGEDEISEADRRMFRQALSELSFRSASRRSSVAPSTTTTALRSHSSHTRSPHSQHSVPHDRERPRHRSHRSHSAAMNDTVTRVRTTSPSHERSSRGDSCHSNEKSAHRCNGGYPHNSRRRHKHESRRHSSVEHRRRPLSSATIPGARYCATQNEEFYSAAHMAKDGAALVSSPLVERIGITPMSMQVLPRLVLRSEIGVSPQRQYNHDLHSNIDAFGHTNGAWSASDDEGEHTVGRVFDAKSDGLRSRPLLLQFSSGTQTDEAAGATLAFGSARSGMPLLVAAPVQRLPAVGPKGNTRNSAHSIARKIASIEDIASTVKECEATSSPISDASASESPASFVKRAVSPTAAAKPFTSSTSHIHSSYSGEAGGGATKVFRDNVGVSKTSTDVPLSVAPVHMTATHSQSVTQHPDTAASAAMGTTASVPLFMPPLMVDDLSQLSHEWQSTLRERTSKAKQDAIEKFLIASAEAGAASTEATVAAAASLPPLCLAGPFVLGENSNMYASGCAGPRVPAVGAEASFERQGCNMPAQAHQGLALQEFYGGSAASAAIPSVSLSAYAIPPQSGPRSFLEIERDVQQRSGSPQSAVQQATGQQQQEERSPSLFTPSKAKYMQETLVARELASGGKAAPVKCRGSGEESSTAATKHSGGKDRGALSECLRANSDGPRPTKPFDLEAPSTVEANDTVDVVDIVQPPLPTDLLSAPSTLAETEEQTRRGNRMCSSSISSRQRSRSVVEKAAPAEGAIAAATNGVGVHSALPLPSFFSVVEPATEAHTSHSVKKAAKHRSGNRHRRNERRKHSSHHGTSASSRRSPSPSSSEASKLHSTKRSKKSKEKKSRYDGDDKHKKRKHGHERHGRCSRSCTRSRSSRTGDATLFEMSDDSEVDSNLTTSMEFQLSRLLLLREAASVKVPTPTAASGASRRSKHDKEKENRKAAAAKKGEHHHHRNRSAKAKKRKMSSKRGEKRRRTSSAGSTVCRISSGAEKRKKTGKEKVRHRSASPPNPWPLPPPPPRQHSNALYGVEATADDAAAGGAVDAKIRSAALRSDWALRYRSLCDDHATLGSPRSILEDHTQSRSCYQSTRPSFRGGSLYTGDQEEGVETDRARHHTETRAGEDTEMLYGHYRRYSHDISPLRGQRPYAASAASRWANGARRAYRPALRADTTVEESSSQHRSHSDPSRPSMRWDDYVLGAERGAAGGPLSPFYTHTGRPQSLAQRRHSRSIDTITGGACSKGGGEGYSRASAQPTSSTCSATYTSRRRQTGEFDHIDDLPIRQYFNKEAVRKNDVKEDNPLVSTPTQDGAEEWRPDNARDFSYLRPRERAGKRTPPLPPPPSPPLASTSPPAVQTDSIFAAIPRSGALPILTEYTVTDAQTAEDFVQGVKEIISALQLYRKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S8P6</accession>
    <name>A0A088S8P6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_205040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_010700401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S8P6"/>
    <dbReference type="GeneID" id="22574716"/>
    <dbReference type="KEGG" id="lpan:LPMP_205040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200057100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_205040"/>
    <dbReference type="eggNOG" id="ENOG502RZ3U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270953at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="346" mass="38777" checksum="B7BE9614D05E39F5" modified="2014-11-26" version="1">MQRDAYAAIVRYRNRRKTPVRVLQMNGAVFHENLMEDFFIGYRNRRLALMTHTPGQDPRLPRLPKDIIVPNYKTFLRIHQPHFMYRLLPLLSSDVEAFAAMQAICASPGSPFTIEDRLESQLLNYRLSKMCAGRDRICEFFKDYTSPEELRMPTATRALPIVGTFFQGLMVHDGLVAATPQTTLFRPPTTEEAAEVPSSTSTGDSRGESSAAAASVGDGGFVVESSNGSLDSTKRTSHKKRANASIAALLTTHDILSEAAITQRSLMAKFLESDLYNQFGSPSVIAAKVRSVDERMHFMAVKRVCAGRTSTAENMRVRVRLLELARKQNLHVYEKVDEGEYAYAMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S9N3</accession>
    <name>A0A088S9N3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_220520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_010700751.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="22575098"/>
    <dbReference type="KEGG" id="lpan:LPMP_220520"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220010200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_220520"/>
    <dbReference type="eggNOG" id="ENOG502RM5W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="767"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="346"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="776"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="901" mass="97987" checksum="56FF048AE3539010" modified="2014-11-26" version="1">MPSIQVAGRHGSYATQFWKPAAWTATTLRFHDRAGMRAAYSRKAIDRRLVLPLDSHNWIRALEVLNAGYARLGRTPEHFQRVLRDMVEHHSSYAECVTRSASAFAPPSLTESPRSLRGAGAGVFDCDSRRLSCSSTEMLVGSEEAPDILPAVDALRDRAYAGEIPSNRSLWVTLVWSYCALDQPSGALDTFHLATRRFRFSSATMQHMATLLLPVLCRHAQLEEAINLYETYLKVNDAKEDLDDSSASSHHRSRLEDADARRWLAEAAAQRGDLKRAQSFAGGARRSPGGVTAADDEPRATANNLSPRPTIDSLFHDTPRLKKLAKLGCGPHLSATSEDSGRTRGPEAAPRSSAAPSSLPVLQTLSCKAVRQLFRSLCRGSSETHSDARLCAALCCWSHLYGPALSAAADLDGDAMSGHCDGTHNCCTSPPPLEDVHELLNLFASHQRWKDVLSIFCRLFLSRPATVYLSSTLTDLQSLSASMGGREGALTAFEAGEAPIAAPALRLDAITLNLLFSSLPAAAAPLLVRAKKLLPTSPRTATKGHDLPQLQHQPRTVGEAYELQLSASAVPVTVVRLLDDLLLLRDDMILTDLVMAAIGPALLQVGQIDRVFDLLARTPMMVSASQRKAPAYVSTEHQALKAELVALGYATFALCPSSARRHEMVRQLPHLFPPEVVRRFASGGEGDTSSSYAVLEDGAVLENHSRVVRRSATTAAALKLDHSLPPHYSANDQCCCSGVDSSQSSSRANITNTAALSLLDLKSHAATPASAGSGGQLNTSTRPGRRSSAATLTSLADDAMRRDYVRLQERRFNAFTGSHADAERDPRPIPKGLHDHASGWDFFGRGGEMVFANHNRTSHPFTMRPKVMRDLRNPYRGWNPRRNSSLAHKENVVKWNGKSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SAE6</accession>
    <name>A0A088SAE6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_231780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699333.1">
        <property type="nucleotide sequence ID" value="XM_010701031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SAE6"/>
    <dbReference type="GeneID" id="22575383"/>
    <dbReference type="KEGG" id="lpan:LPMP_231780"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230025900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_231780"/>
    <dbReference type="eggNOG" id="ENOG502SDRA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272361at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="473" mass="51924" checksum="85D7007F766B370A" modified="2014-11-26" version="1">MGSMPVSSPMPDKRVCLFFDCRVAGDGRGYEELRRTVHTQCSQLLILSHLHSSGSGTTLSVTVHLVTHTRVEYFATLLCAATTDKPIDSGAIGVMNGLRALADAQPDHRIHACGAATFGNRMESVLPHIQRALGDSQQRRQLILFCSSYVSHTEATQSLSGLRLDASPHQWMRCILVDWEAVCVTVGELTSSVRVYRCSLSARQLQAAVQDSLSLFLLPDARSLRRLGLQLGLQTLPVVATVWHYAGLPGKCDTLNSVLRADRAPPAAAPVARGMVHQRLAETTRRHAPFTAVSMVERGGRDTLSILHLRAVLEADKVDESLLLGDTWVLTLDPSAASTFTSTLTSSSESPWSWDASTVALWHAFCDTFLGDALVLSGEDTGIEACRHAMQSHHHFVAYFMPDRTMRVREIVPPELRFVPLPAPLMRKGLQEQRVYQAEMHRLRQQLVSHCASASFSLDTLLSSGWRGAMSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SC26</accession>
    <name>A0A088SC26_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribosome biogenesis protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_261230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699943.1">
        <property type="nucleotide sequence ID" value="XM_010701641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SC26"/>
    <dbReference type="GeneID" id="22576026"/>
    <dbReference type="KEGG" id="lpan:LPMP_261230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260017200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_261230"/>
    <dbReference type="eggNOG" id="KOG2321">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273340at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056551">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040382">
        <property type="entry name" value="NOL10/Enp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056550">
        <property type="entry name" value="NOL10_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23098">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23097">
        <property type="entry name" value="NOL10_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar protein 10-like N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleolar protein 10-like second" evidence="1">
        <location>
            <begin position="391"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="699" mass="76919" checksum="ACC1A70784F5535D" modified="2014-11-26" version="1">MQVSLHNTVKTYNLTAGKSLPEWLSERRKNKRASAGQENRVELLHDLEFPHCARCIFRCANGTHLFAAGDYPYRLKCFDVNDLSMKFSFNADMNILSGVCLSPDYRKFALRGEGRQITIHHTSAIVDRVRVPHLQRSLVYNQFQAELLSSGVSPEVYRISLETGGFVEGYQTKSASGVNHVEVFGRHGPVSGVVLTAGCDGAIEAWDSRVGTAVARVQVAGSGSSSGVDEQCEVRHIATEESGGLLFTCGLESGEVLLYDVRLQKPLLVKDHMNSLPIVKTYFFNGKSTATGEASFVLSADTRSLKVWNKHDGSNFTTIDAPADITDFTLFKGQHNMVAPYECDDSGVVAICCDVPRVQVHFTPQLGRAPRWASFLEVMTEELEEKEATTVYDDFTFISKDEMNALGIAAEDLAGGKVRPVMHGAFIENGLYRELRAVVDPTAFNNYVASKAKERQLKRWSDRISRFHRTKEVDEDAEDVKVGGDTAARAKANSALATAKADPRFAHAFGHATGGAASSFALDRRNPEYAKLLQTIDERRAKASARRERYEAEMFSVVPDFDGENCAAEYEDGSDRAVRGAGQRQASRNSVSAAAVAEVDEDEDARCHLRGVQSSGRAKRRTPQKQQAAINAKMSERGSAKPTKAVTASAGRRVTMFEVPSKNADIFLRNDKQMHATRKKSRAEKLTLGERLKLAASAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SDW6</accession>
    <name>A0A088SDW6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Enoyl-CoA delta isomerase 1, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">3,2-trans-enoyl-CoA isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">LPMP_290010</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Key enzyme of fatty acid beta-oxidation. Able to isomerize both 3-cis (3Z) and 3-trans (3E) double bonds into the 2-trans (2E) form in a range of enoyl-CoA species, with a preference for (3Z)-enoyl-CoAs over (3E)-enoyl-CoAs. The catalytic efficiency of this enzyme is not affected by the fatty acyl chain length.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(2E)-tetradecenoyl-CoA = (3Z)-tetradecenoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:29847"/>
            <dbReference type="ChEBI" id="CHEBI:61405"/>
            <dbReference type="ChEBI" id="CHEBI:61968"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:29849"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(3Z)-decenoyl-CoA = (2E)-decenoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:77195"/>
            <dbReference type="ChEBI" id="CHEBI:61406"/>
            <dbReference type="ChEBI" id="CHEBI:195601"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:77196"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(3Z)-dodecenoyl-CoA = (2E)-dodecenoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:23716"/>
            <dbReference type="ChEBI" id="CHEBI:57330"/>
            <dbReference type="ChEBI" id="CHEBI:58543"/>
            <dbReference type="EC" id="5.3.3.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:23717"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(3Z)-octenoyl-CoA = (2E)-octenoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:46044"/>
            <dbReference type="ChEBI" id="CHEBI:62242"/>
            <dbReference type="ChEBI" id="CHEBI:85640"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:46045"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIN99951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700894.1">
        <property type="nucleotide sequence ID" value="XM_010702592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SDW6"/>
    <dbReference type="GeneID" id="22576765"/>
    <dbReference type="KEGG" id="lpan:LPMP_290010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290005000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_290010"/>
    <dbReference type="eggNOG" id="KOG1683">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1696280at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000034">
        <property type="entry name" value="Enoyl-CoA delta isomerase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF172">
        <property type="entry name" value="ISOMERASE, MITOCHONDRIAL, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00056147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AIN99951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="296" mass="33044" checksum="A489D3826494F811" modified="2014-11-26" version="1">MRCRRPSFYVRPQLWRACSTTASMSDTADLVVVRESPLEKVVLLEMNNGRANVLTSEFISALLQTIQDVCNPEKSQCRGIVLTSKTPGIFCAGLDLNELNTNLSRDRFAHYWGQFQQLFRTFHSLPVPLVSAINGHAAAAGCIIALASDYRVMARRHPTKPVDLMIGIAAAQHGFVVPPYVAGSMEHVVGFRKAEELLSLGLLLSADKALQVGLVDEIVEHHDEAVVPCLQFMEKLLELPSAAPYWMIKDMSRRHLLAPLCTEDLRTQDTVSFYNLFSNSQVKQTLAQHIQKLSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SF51</accession>
    <name>A0A088SF51_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_302140</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701237.1">
        <property type="nucleotide sequence ID" value="XM_010702935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SF51"/>
    <dbReference type="GeneID" id="22577267"/>
    <dbReference type="KEGG" id="lpan:LPMP_302140"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000020700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_302140"/>
    <dbReference type="eggNOG" id="KOG0146">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271725at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001043">
        <property type="entry name" value="RNA-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001110">
        <property type="entry name" value="RNA-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="5"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="96"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="175"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="396"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="397"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="417"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO00437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="496" mass="53506" checksum="1136700006369B33" modified="2014-11-26" version="1">MTTLQNLFVAKLPRNLTDADLEQIFLEYHPTNAKVMLDATTSRSKGFGFVFFESEDVGREAYEKLNKTHVTLHGHNFTLCIFPSKHDGKVAVEESKALYVRNIPLKLSQLEVEQFLRGFGPLTYCAMREDSVGGSVWVVYAEYDTVESAKSALASLHGNRFYFNTSVAILAKYADSEEAKRERRRRREQQQQLTVKQHLSTAHNSRSHRVGHGSTRGFADHANNALLPPPPPICTDNSVPHTNSTPETRMEGAGTSQQSRVFASISHHFSPGRVGGAPPPPGMGQPVASPALLTAGLSTMQQPPPTQTVLVQPQQSPTFTSGSFLNVTFNPTNASTFGNNFTHYGVLDQTPSRSYPGTPLNFSFGPEMENSGALPNGCSVGSNAMLDASAHALTTPVHRSSNLSPSGSYRHNPYAPVTPVSSTHSSTGPSSPLVSSIPYPTAPLVNMHFGASHQVQGSPVVPYPPGQGIGLTNNHFSSRGNNTYLAAPASLNDLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SFU3</accession>
    <name>A0A088SFU3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_310530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701442.1">
        <property type="nucleotide sequence ID" value="XM_010703140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SFU3"/>
    <dbReference type="GeneID" id="22577479"/>
    <dbReference type="KEGG" id="lpan:LPMP_310530"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310010300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_310530"/>
    <dbReference type="eggNOG" id="ENOG502SI98">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272989at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="601"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="352"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="418"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="514"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1264" mass="136266" checksum="17AD9BBF25854555" modified="2014-11-26" version="1">MQTAPPTQRRRTFSRANGADGTTVPHLVAAEERHRKNLQQIQQLKQALCSTVSGAGAPNMSAPSSRGWSSPSSTFSVPAPSGPSWMASSFESPNGVMASPLPTTGGTTPEPHRPMWTSASAAALRESQQEVEHLVRERNKLQRQCLEWASLVSAAPHRALPSAGTDAPLAFHSVLEAGAWSPVHEAALAVVKQVARFYPSAVHEVESKSDVVTEDASAPLCARSSALFAAHEGELSALRLHNNSSPPPTAEELADALHRVAKFLPRLASMTSAREPVAALGPDLLHHIRALEEEKQSDCLAVLSIVDHLTEVATRLQQEAVEKDEALRVMQETVGGLMEEKSQWAWRARASEEALAERYEQHSQREKAWERELAELLQLKQNAEAASAAPMELPTPTTVHLAEDTRAASAKEAGDGHIAHLQQVLDTKEIVLSTLQEEHRALQVMHAELQTQSQKAETAHHNRIAALESQLSQLEAELQTQLGIIKSTRRKAEDVPQAHPAETAALAEYSRAILAGKEAALPSLQEAKEEVEVEVVEHTADVAQIHAELETASDKLAAAQSTSDRVGSFLLVCDGVSGSNSPVAVSTGPLRLTGLREDVAEGNGAGANVPLQMDELSTPSRRERAGSDDVEEAADSPTKHMDVRKLQQSLKRMSRENTALKRKLEHRGVALAEMEGELEAAQRLVAQRDAQVQGLTAELEKARVTTAWAPAGAKVADEDDTGEETDAETPLQLLDFSELERYEDEGTLYPDPVDLSEWLLGSTEGSSVRFSTYVQQHLSENEQLRITAVGPLYHMGFTLLQMEGLVRQEAGPFCLPMTWCRFLLQLQQVLDTQLQASVLSPADSAKCFYALASSAGLFGSRANPPPDPLTAYSLIIAALCVCLRSSAASSSINSSSKWHCCQAILRHVSHYGVGKAMSQMGRNITDADSQVPDDLFAALCAEFPPATALPEEDAGDESRAASDGTASVAPLCSVRLAALLSSDFLSDCLPISTFALYVAALSDIVNVKVAPDEHLLAANLPTETTQFFEVARPRLSSTQEHDVTPLLLYAARHEYLLFGWAQEMDDAVAEAEGSAPSGDCHSADTAFLTLSSLGVSSTWPASTSVPKAPPCSATVSASAPSPTEVESITQLLIFLCTGVLPALVLAAYHCPSLERESHVINALFRTRRLLMAKRTALLAKNPTEASATSEVVPGASLLLPEARLRNLVNAALAPIKHTAPFPERAVQVPVADYERLHHELLSLYETNETYHGYIRELLSAVETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SK25</accession>
    <name>A0A088SK25_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_350010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the histone H4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702942.1">
        <property type="nucleotide sequence ID" value="XM_010704640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SK25"/>
    <dbReference type="GeneID" id="22579030"/>
    <dbReference type="KEGG" id="lpan:LPMP_350010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350005500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_350010"/>
    <dbReference type="eggNOG" id="KOG3467">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="257350at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000058">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIO02142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="100" mass="11374" checksum="0ADD5AE2C102E61D" modified="2014-11-26" version="1">MAKGKRSADAKGSQKRQKKVLRDNIRGITRGCIRRMARRGGVKRISGDLYEEVRRVLKAYVEDIVRCSTAYTEYARKKTVTAADVVNALRKRGHILYGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SK35</accession>
    <name>A0A088SK35_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_350170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702957.1">
        <property type="nucleotide sequence ID" value="XM_010704655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SK35"/>
    <dbReference type="GeneID" id="22579046"/>
    <dbReference type="KEGG" id="lpan:LPMP_350170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350006700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_350170"/>
    <dbReference type="eggNOG" id="ENOG502S0X2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="274787at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36706">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO02157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="155" mass="18671" checksum="39B2B20F58F2CF86" modified="2014-11-26" version="1">MSDTAHFTRVKAIPETLNPITGRSVYYGMRPWRCDDRFQDWLKSFTCFDSVSVQYNLLKLFFQCARSEEGQEPIDNYHRLGRGEVMYYVERYRTGMMRTGVWETYPYDQNELRRVAEEDGLKMRVWRHQRELEMESKEGKIDDVLQMNVMRRGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SLQ4</accession>
    <name>A0A088SLQ4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_356130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703542.1">
        <property type="nucleotide sequence ID" value="XM_010705240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SLQ4"/>
    <dbReference type="GeneID" id="22579641"/>
    <dbReference type="KEGG" id="lpan:LPMP_356130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350069700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_356130"/>
    <dbReference type="eggNOG" id="ENOG502RJ3X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264469at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019396">
        <property type="entry name" value="TM_Fragile-X-F-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13568">
        <property type="entry name" value="FAM11A, B PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13568:SF9">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="601"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="611"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO02742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="636" mass="72533" checksum="D7DB01A7B8A0821E" modified="2014-11-26" version="1">MDVDRPVHKPNWRLYYLLDLIPPTTSRQVKWNFRKVTLRHHYYQAYLVLYNRSRKYLYDSIGEDAYGFISSGTWGPLVPVLGAVGTVVVYSLVLLVEVALLIFFFVFLAVKDDNYISWNWEFILLPLMIFVTIMIAVSVVALAVNVITPRTYEEGMSKIDRLSPVGNLFAAVCYFCIPFVFFTQIRNGAQLSRGFYLQYMSMPILGDIFYYATSLIWRWPRRVRLQAEVDNIRPSSVIYYGIFSMAFLNMACGVAQWVLIGLKLDGRLNHSWYIIFIPFCVRAGLRVAEAYLRSLMKYTIGVRMDTGVAFDTVGSFFSNGILLISLYFVAVRLERGREKVRLLHALIPVYSTLAWIFLCLIVTMIMQLILYRHHSREERRINSQWTPPQDKDDEATKTLGGTDTSDSAPVRFFKTMQRNWDDVDVATASLTTYPPGLDNHSDSEEYEDFVTDEEEPVFTEAVEQRLQAPSDRHRSDDGEVAYRGKTPISNQDDSSGYGASRRTTSTAQRARDAPQRAAHSASDRDVRGASSRRPTPRRQTPDVYSGMPASAISGEEDYTEVTTYMDERTAGSDTYEDATYSNSYTYTDQTTYFDQGADYTSENQVESHTRSSSYSSVSSSFSSVTSYTSKNAVTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4W4</accession>
    <name>A0AC62A4W4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3420550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="XUY36819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="738" mass="77409" checksum="396F4C8DF9DABC81" modified="2026-01-28" version="1">MNSYRLEVAVKRVSGLNPLIASASSMIAVEVRFLNFPPIMIHPQGYAVGDTVTYNVCHKADFRMCSEQAAANFPAMCQCQLVSVNEGAVAGGARWSCPCLLVPQPDAAAQLSLRTYANYVISNAAGGAVGYADMSCRVLLQDPPSTAPVPISMPAPQASVTPLPVAAPPASALEPSRGTSADQGKPYIVRVVVGESDRHRRPSQATRWDGVQDTSRGHEVTVTRASASDRGQPSRCVSANTAEKGSLLHLLQYDVAYQLQSLSETVAAALHREHDVLTRTPLKGPDKSDALSTSRLTKSIDHHVASIVKVANIVLQVVNQLVDNSPATPRIGASRVVKDMARQMRNPVNKLPLPAEDSIGHYLQYDVLYQLQCLGTNLSYMTVAYRAVLDTPLSSIPVQHVAYCDELGHEIQHLTKQISILVQSCVDGTLSTAALSAAPRPVVQKKDQKQRKANSRSAPQAAAAHLGAHKLSGAAKSFSSTSYSSFSNSRGTSTSSLSSSCLSSSLNRPATPASQPRAPTIVAAPTNPLPAGQSSLAATPTPSAPAQPLPPPPSYATPAATTPRKQTSPSPPTPPPPYTVAAPPAEQTAMSLLTPVGSQMWLSPFNPMDSLGEPTALSQANPLVPRVSHINQANNFQLSTAAPPRDSLHPGSQSTTVYGMTTSAFTPQPVLATGGPPALSPQHLSLVPPPLAAPTPLTPPSAAPSPPPMATSKLATPPPIQPQPPVPLTIPIPVPIPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4X8</accession>
    <name>A0AC62A4X8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Elongation factor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3520030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="XUY36834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="845" mass="94218" checksum="D34927335D0EFFF3" modified="2026-01-28" version="1">MVNFTVDQVRELMDFPDQIRNMSVIAHVDHGKSTLSDSLVGAAGIIKMEEAGDKRIMDTRADEIARGITIKSTAISMHYHVPKEMISSLDDDKRDFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCVEGVCVQTETVLRQALTERIRPVVFINKVDRAILELQLDPEEAYQGFVKTLQNVNVVVATYNDPSMGDVQVSPEKGTVAIGSGLQAWAFSLTRFANMYASKFGVDELKMRERLWGDNFFDAKNKKWIKQETNADGERVRRAFCQFCLDPIYQIFDAVMNEKKDKVDKMLKSLHVSLTAEEREQVPKKLLKTVMMRFLPAAETLLQMIVAHLPSPKRAQAYRAEMLYSGEASPEDKYFMGIKNCDPAAPLMLYISKMVPTADRGRFFAFGRIFSGKVRSGQKVRIMGNNYIYGKKQDLYDDKPVQRSVLMMGRYQEAVEDMPCGNVVGLVGVDKYIVKSATITDDGENPYPLRDMKYSVSPVVRVAVEAKNPSDLPKLVEGLKRLAKSDPLVVCSIEESGEHIVAGAGELHLEICLKDLQEDFMNGAPLKISEPVVSFRETVTDVSSQQCLSKSANKHNRLFCRGAPLTEELALAMEEGTAGPEADPKVRARFLADNYEWDVQEARKIWCYGPDNRGPNVVVDVTKGVQNMGEMKDSFVAAWQWATREGVLCDENMRGVRVNVEDVTMHADAIHRGGGQIIPTARRVFYACCLTASPRLMEPMFVVDIQTVEHAMGGIYGVLTRRRGVIIGEENRPGTPIYNVRAYLPVAESFGFTADLRAGTGGQAFPQCVFDHWQEYPGDPLETKSLANATTLAIRTRKGLKPEIPGLDQFMDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A500</accession>
    <name>A0AC62A500_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pyruvate kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3420020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="XUY36761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="424" mass="45837" checksum="7311FED40FD30799" modified="2026-01-28" version="1">MSVARMNFSHGSHEYHQTTINNVRQAAAELGVNIAIALDTKGPEIRTGLFVGGVAVMEKDATCYVTTDPAFSDKGTKDKFYIDYANLPKVVSPGGYIYIDDGILILQVQSHEDEQTLKCTVTNAHTISDRRGVNLPGCDVDLPAVSPKDCADLQFGVEQGVDIIFASFIRSAEQVVEVRKALGAKGGDIMVICKIENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEKVVVAQKILISKCNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNGVVQYMARICLEAQSAINEYVFFNSIKKLQPIPMSAEEAVCSSAVNSVYETKAKALVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNITQGVESVFFDADRLGHDEGKEDRVATGVEFAKSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A591</accession>
    <name>A0AC62A591_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histone H3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1620110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="XUY37022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="66" mass="7238" checksum="D87F239EB5F19D1A" modified="2026-01-28" version="1">MPCARCRACRRRGGPALPEQRDPGDPGGVRCVADGCHEPGQHPREACVTVRPKDVQLAVRLRGERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5N4</accession>
    <name>A0AC62A5N4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Zinc transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2820040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="XUY36921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="424" mass="44134" checksum="2BEF6A92A570FE54" modified="2026-01-28" version="1">MTRPTLTMYRQLYRDLVRAAFTAEAGEPLEWQPVVASGAAALADPDGGADSHGHNHSGEHGHSHGCNSVEGDYMLALHIAAIFIILAASAVGTLIPIVGKRVPALRLHAYVYAVGKAAATGVVLAVAMIHMINHAATVLALDCIPASFSELYEGWAFLFAMIAAIVMHAIDGTIVWIAERWTARAGGESSSSDPCRDSCAECPAMRDGEPVPTQTECVFKDAGGGMAGGKSGDSVDQSDGAKCVGHQHGVAVPEDLPAAQRVVAAVCMEFGVTLHSVFVGLALAVSNGADLRALIIALVFHQLFEGLAMGARLADASFKISLEIVLMLVFSLSAPIGIAAGTGAVVASRDALSGTTYALVSAILDAICGGIMLYIAFNLLFVDFPADLRVHCGPKSRNSVAKRIGMYAGLWIGAGVMALIGKWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5U9</accession>
    <name>A0AC62A5U9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histone H3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1620520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="XUY37063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="66" mass="7238" checksum="D87F239EB5F19D1A" modified="2026-01-28" version="1">MPCARCRACRRRGGPALPEQRDPGDPGGVRCVADGCHEPGQHPREACVTVRPKDVQLAVRLRGERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A611</accession>
    <name>A0AC62A611_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amastin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2020420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="218" mass="24198" checksum="CCC1F442A803F04A" modified="2026-01-28" version="1">MEWNVPILIYAIVQFIAFVLVLFGTPIDMYRFRPRFITPDTTVTTLWGVKKGGFNSTNVISSDYLWRRCIVRRDRFRLAQAFAVISIFVYGAAAALGFIMLYCCSFFRMVCLALNIVGAVTLCIVWAAVAVTYHIEDNEFCRKESVFSTYGAGFVLLLLAWLLDLFNIVVLLLPISIAAGGAGGSSSKDSKKQDESSNGHSRESSMEGSRQNDLSEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A672</accession>
    <name>A0AC62A672_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amastin-like surface protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2021030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="194" mass="22191" checksum="6A5C0B5FCE518DDD" modified="2026-01-28" version="1">MEFNPFIIVYAAIQFIAFLLVVVGTALDMFRLQSRENFEDRPCITLWGLKPYCNSIVYSLSSDERFSLCPVRRKRFHMAQILAVVSVGVYGTAFALGVIMLYCCLHLRWVCLLLNIVGFVILPIPLALMVLSYKTDENSLCPKLRDDYDFGVGFYIFATAVGMDFIDIVFLLIPWQYDYLDVTCNSKEGNSQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RH95</accession>
    <name>A0A088RH95_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_040200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="AIN95347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703669.1">
        <property type="nucleotide sequence ID" value="XM_010705367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RH95"/>
    <dbReference type="GeneID" id="22571979"/>
    <dbReference type="KEGG" id="lpan:LPMP_040200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040007800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_040200"/>
    <dbReference type="eggNOG" id="ENOG502SHDN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266540at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="260" mass="27950" checksum="498CA1BD9BFBDAF1" modified="2014-11-26" version="1">MEALTNVAFAGYAYYSAAGDGFVYALRSKDSSATGSPVILVDPTAKAAHFFPCLFLVAGGTLMVSLLAFVVVAFCCQRKVAKLEETYWTLQHTFADVNDTLVREVSRRTSAAAATSSASLKQRCTSKSNSQRVAGSQSPSPMPQHRGSTASMTSIRQPQHIREQPPAAPVFPATPSPYGMNPNPPYLQPMNVSPMTMHNFSYNDNCVQAALFPPQALPVPLSPSQHHTRTLGGFVAPQSTCLTPDQPLRRRASKVSFVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHH5</accession>
    <name>A0A088RHH5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_040110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="AIN95338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703660.1">
        <property type="nucleotide sequence ID" value="XM_010705358.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22571970"/>
    <dbReference type="KEGG" id="lpan:LPMP_040110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040006800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_040110"/>
    <dbReference type="eggNOG" id="ENOG502S61W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273216at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1783"/>
            <end position="1803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1803" mass="195801" checksum="A4EB90B317D2F341" modified="2014-11-26" version="1">MSSPVTSAPPAPPSPVEVHQVIARAGQRGQWERATHLFLGALHSHCVPLAETYQLVLLAALRGGGWQASVQLTKQVATSTLSTTALYHTAADLLLAKPTVDVRTSSKSLDRVVLEELVPLMLADATRHVVWRPRHRVAVLQALGKAERPQKMSVLFRRWTASTYLYGGVSRLRCSEEEGTLLMAAFGATGDWRSAETLRASLSQASAPLLVNYVRAFAVALQQTGVSSLAEPQQLVPWEMALDIAAASKQDAPLLAAVTELLNAARHAAGPADGARWWWAASTSTHAKLAELRRRVAISTRAAAQLLVEYHVTAVQVKNLLDAVRISGVLSSEAAEVSPYYVEWVNVVLVLSQYCPHALVSSDGCADGLLLLLPHPHQQVRQQRDGSTLHSLALWQYVVQSVTGRDLTNPTSVARHVIYTSSVLHYVRHAALQPAQLTKAEGSLSAALARQLYLIDHRLTHDALLTSSTGKPDALSVLLRTVSAHIHVPAAERCVRLLLCDEASSVGELVDGLLLSFLGPLNALGTPGEMCEAVCVASEAALLSSPLCYSSAQLVCLTVWYTCHQLQRGVPLVALRPALHRTASLVQQLPRSADALMLLSTQLQWCWGASLEALRSQAVPILLRREEWGILARLLECCPQPLSMQEQRILARCKGGAKVTALQNLVTAQFAKPAWEYWQGELCGTAPELPLPTSLHDSLVSLLLAQGLVTEAHTVLAGSGASMARVSRTTWSHIGLRAYNYARRWRRRQKGLQLAELWDVAALGEGGADFDDSEVRRRELTMVLALYASLALEHTQRAADATQVIAAAVDYVLQYDEAHHHRSPQRPLDFTTLHKTDTQLAAHLPDYVQCTAPRLICAALDFGDGSSSQPAMDNACSEVDGGAVSEAVRTVEFLLPLTSTSEAAVVAWSETVARLYTAAAAGATHAMSAVAALGQRLLCQAAGQNVAVAPSFLRLVLATGPLSTTLLAAARQCLLLIRDKTPTDPCRADVATTAMQVALLLADSGKHSEALEWVEKFELWARSEAAAKGETVPDPQTVMDSATQLSWLQVAHRTAQQRADQRAALCQRRREAQTAVSRVSVMLELYSRDALNRLIDCDAWEEALDAFLYVVATPPDVESLLSEGSMELMVLRDAYLSADVLNCVLLCVARSAPWRTTVQAWMLLISQVPLLPWRNCAAAITPSIHELLSAMTRENALPHEVGAVVEWMVAQLNLPTSATSVLCSFFADCVGASSSTGAGCAWTAAEAQLCAEIIAQLRRLCSEQRVQEAGRAISEAQEVLFPPPFHTLAPHSEEATALSVAPLAGSWLPPGRPPLSAEEVDTLAVVAPLLLLSSTPQLESLARQHLGGVFQAHELKALLHLYREELLQRIAAAREPDASIVQYLAQNATLRVLLSQGAEVRQAQHPEVRTRNRAAAAWMVQHVFDGFLPLSTAEELWRACEEPAARLAECRWSAVAEAELCELLLQHHGRPPTKLSTAPHLTRQAIAHYWSCFHRVLLPDMHFDPLELCCLASYAPALTEARALCPDITKPAYAAAVAELASHAYKSHFCPSRVPAEDTLAYTRRPHCPAAIAAVMTRAFKKLKVLHAQLSKVSSAAACGYCFPFQWDTRPAAAVQPPPELDRQNLATAARRIAHGATPATEVAPVRASHACITSPLLRQWTQWATRMAYAASPKSLPQAASLLLVEWTKEALQPGSGHRRADQARSEALKAAGGDNGVRVLWQEVARAGKRELQQRRCRDLSVVWRLLTSAEVWRTMDAGHVVVLRKLVCPSNAKVTALPPKHDAARYHTKKPQRKEKGGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHX1</accession>
    <name>A0A088RHX1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_050560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="AIN95498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703820.1">
        <property type="nucleotide sequence ID" value="XM_010705518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHX1"/>
    <dbReference type="GeneID" id="22572134"/>
    <dbReference type="KEGG" id="lpan:LPMP_050560"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_050011100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_050560"/>
    <dbReference type="eggNOG" id="ENOG502R4MY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264985at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="402"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="466"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="611"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="673"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="727"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="779" mass="86359" checksum="0AC68E1A04D3572C" modified="2014-11-26" version="1">MEHSVSSRSPSGQWYPQQQQWSPASGTATPMVMMGGGQPATVPVSAGSAMVGNSGIFINSQANVGGQPRPSMTPQQQMMMMQSMYTPQSQCCAPCCGTQESSLCPQPGEPVNPFCCTPRRPDQEPKWWESVYRYFDWTFLLACVICVLTIVGFAMVIATRRQDNLFAVFDVHNTTALEKAIQPFIRWINVSVAPPIVSRGGSINNFAKGSFSGSLKAAERTRFIAAEHDIVAAAPLGPVKNPDLTKSSLAPKCTQRKLLGSFGVICMEDNLHANTLVVQLSYWSNSRDTLWILAMVYSILTVLYAVLTNVHRHSSSTGTGDPHGSPSTLPTITPQQQEEFVKMTPQQQQAFIQEFQQHVAVMQQQQQPNAAFLPHNSPKGGCCGTDSGIEFYETPFYEFVRMAWFASGITAFAWTCNLFISFWSFDQFYIRETTGPLRTFWVIYSRRMNATLIVVTVFLAWPLCNFVLELVMLVALVLPWLVIRSTCKRGIQMYRPALPLSKMPGYIRADMFFMDFQDVKRLGFSRMAWMMLTDTDKPFFEGCEDPTVDKDPAMTQLMQQRIQWSQMMVSMVPPWVQQQQQMGMMGVGGAGMMQLGQSTPWQRQLDVNAQTTLPGNTPLQSPAQYPVEDAEGRSHKRRRHRSTRDHRHGDPLAVTPMETSVGLAASGKENSTRHRHRRHSHSHSRSRSRSRSHSRSKGAFDGGIPQPPGTDAAVSNGAMVPADGVSRHHHHHHRHSRSRSRAAGEDASAMAVAVPRGTGDAGHNGGASAAAELDALMQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHZ5</accession>
    <name>A0A088RHZ5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-methyl-5'-thioadenosine phosphorylase</fullName>
            <ecNumber evidence="4">2.4.2.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">5'-methylthioadenosine phosphorylase</fullName>
            <shortName evidence="4">MTA phosphorylase</shortName>
            <shortName evidence="4">MTAP</shortName>
            <shortName evidence="4">MTAPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_050810</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>S-methyl-5'-thioadenosine + phosphate = 5-(methylsulfanyl)-alpha-D-ribose 1-phosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.28" evidence="4"/>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="AIN95523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703845.1">
        <property type="nucleotide sequence ID" value="XM_010705543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHZ5"/>
    <dbReference type="GeneID" id="22572159"/>
    <dbReference type="KEGG" id="lpan:LPMP_050810"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_050012800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_050810"/>
    <dbReference type="eggNOG" id="KOG3985">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="431409at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09010">
        <property type="entry name" value="MTAP_SsMTAPII_like_MTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1580:FF:000012">
        <property type="entry name" value="Probable 6-oxopurine nucleoside phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01963">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010044">
        <property type="entry name" value="MTAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01694">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679">
        <property type="entry name" value="S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679:SF2">
        <property type="entry name" value="S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 4" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="5">
        <location>
            <begin position="12"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="60"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="224"/>
            <end position="226"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="4">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="4">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN95523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="306" mass="33212" checksum="7840FC27FB5AFEA5" modified="2014-11-26" version="1">MYSNPHVCPVAIAIIGGSGVYKLKCLQDAQHYDVLTPYGSPSGQLCVAKVDGVPCVFLPRHGPHHQHTPSEINYRANICALKQMGVRYIVAINTVGSLDDSYRPGDLVLCDQIIDKTYARNTTFFENGVVAHVNFAHPTSHALNTIAHQALLRCFPDVAAGKGAFKIHSSGTLVTMEGPQFSTKAESLLNKQMGGHLIGMTTATEARLAREAEIAYAVVAMVTDMDAWSDAPHVDVSQVMKVVAANSEKAQLYPPEIIKALAESPFEDPAHHALKDAIMTKPEHIPTEVKQRIQPLVAAKYPQFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RI55</accession>
    <name>A0A088RI55_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trypanothione reductase</fullName>
            <ecNumber evidence="5">1.8.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">N(1),N(8)-bis(glutathionyl)spermidine reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">TRYR</name>
        <name evidence="22" type="ORF">LPMP_050340</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Trypanothione is the parasite analog of glutathione; this enzyme is the equivalent of glutathione reductase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>trypanothione + NADP(+) = trypanothione disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16757"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58290"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58661"/>
            <dbReference type="EC" id="1.8.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="17">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.12" evidence="5"/>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="AIN95475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703797.1">
        <property type="nucleotide sequence ID" value="XM_010705495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RI55"/>
    <dbReference type="SMR" id="A0A088RI55"/>
    <dbReference type="GeneID" id="22572112"/>
    <dbReference type="KEGG" id="lpan:LPMP_050340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_050008100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_050340"/>
    <dbReference type="eggNOG" id="KOG0405">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5956163at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015042">
        <property type="term" value="F:trypanothione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000051">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000019">
        <property type="entry name" value="Trypanothione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000233">
        <property type="entry name" value="Trypanothione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046952">
        <property type="entry name" value="GSHR/TRXR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001864">
        <property type="entry name" value="Trypnth_redctse"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004776">
        <property type="entry name" value="PRK06116.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01423">
        <property type="entry name" value="trypano_reduc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737:SF2">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00470">
        <property type="entry name" value="TRYPANRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 17 19" id="KW-0274">FAD</keyword>
    <keyword evidence="8 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="17" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 19 22" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13 19" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="21">
        <location>
            <begin position="5"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="20">
        <location>
            <begin position="363"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="461"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="160"/>
            <end position="162"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="195"/>
            <end position="202"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="18">
        <location>
            <begin position="52"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="AIN95475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="491" mass="53309" checksum="DBC95A213FB9BFB9" modified="2014-11-26" version="1">MPRAYDLVVLGAGSGGLEAGWNAASIYNKKVAVVEAQKEHGPPCFAALGGTCVNVGCVPKKLMVTGAQYMDLIRESCGFGWEMDRDSIRSNWKKLITAKNKVVSDINKSYTGMFENTEGLSFHMGFGALQDAHTVVVRKSEDPKSDVLETLEADYILIATGSWPTRLGIPGDELCITSNEAFYLDEAPKRALCVGGGYISVEFAGIFNAYKPPDGQVDLCYRGEVILRGFDLEVRKSLMKQLEANGIKIRTKVNPSRITKNADGSKHVCFEDGTEADYDQVMLAVGRAPRSKALQLDKAGVKMGKNGAVVVDAYSKTSIDNIYAIGDVTDRLMLTPVAIDEGSAFVETLFGCKPRATDHTKVACAVFSIPPIGTCGLTEEEAAKKYDVVAVYESSFTPLMHNISGSKHKTFMIRIVTKEKDGEVLGVHMLGDSAPEIIQSVGICMKMGAKISDFHSTIGVHPTSAEELCSMRTPAYFYEKGKRVEKLSCNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIM2</accession>
    <name>A0A088RIM2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_070570</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP009376">
        <property type="protein sequence ID" value="AIN95743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704065.1">
        <property type="nucleotide sequence ID" value="XM_010705763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIM2"/>
    <dbReference type="GeneID" id="22572392"/>
    <dbReference type="KEGG" id="lpan:LPMP_070570"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_070010900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_070570"/>
    <dbReference type="eggNOG" id="KOG0749">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF42">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="79"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="175"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="278"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN95743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="362" mass="39874" checksum="A81A1F7E2FFEE9FB" modified="2014-11-26" version="1">MPTTSVAAQGSSGGGGSAYRSGERSFTSSSLSHGGTREAEHAGPSCSPQPCGSASQHDRQQRLYEEDGLTLISVEYIQRLWLMRAVSRTVLAPLERVKYVMQCQKELQRAGALQCEFKTVWSCVSYLRHMEGTRSFWRGNLIQVVSLLPILLAQVFIAYPTQSFIFNFCVTHSVVDYTVASYAALLGGALAATMVSYPLEYARFRLAVDVKSHVGASYKFRNSFAFYSHPVMSECPHLLYRGLTLFIFGSVVYQSVQNALLNLIAPYVPPDEEGSGWTPAIIQTVCGLTVSGTTTLCLHPIDLVRHRMMVAVMEDRLQYSSAMKCMVRIAQKEGIRGFFRGGTVTLTKMITATGLVLVGLPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIS2</accession>
    <name>A0A088RIS2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nuclease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_061060</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="PLoS Negl. Trop. Dis." volume="10" first="E0004326" last="E0004326">
            <title>The Dynamics of Lateral Gene Transfer in Genus Leishmania - A Route for Adaptation and Species Diversification.</title>
            <authorList>
                <person name="Vikeved E."/>
                <person name="Backlund A."/>
                <person name="Alsmark C."/>
            </authorList>
            <dbReference type="PubMed" id="26730948"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">L967/96</strain>
            <strain evidence="7">MHOM/PA/71/LS94</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KM411722">
        <property type="protein sequence ID" value="AKK31171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KM411723">
        <property type="protein sequence ID" value="AKK31172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703987.1">
        <property type="nucleotide sequence ID" value="XM_010705685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIS2"/>
    <dbReference type="GeneID" id="22572312"/>
    <dbReference type="KEGG" id="lpan:LPMP_061060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060017000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_061060"/>
    <dbReference type="eggNOG" id="ENOG502S61M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="430293at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302">
        <property type="entry name" value="EBNA2 BINDING PROTEIN P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TNase-like" evidence="4">
        <location>
            <begin position="33"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN95665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKK31171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKK31172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="224" mass="25083" checksum="B36027AEDCFA855A" modified="2014-11-26" version="1">MGNSCCRDDHQTAGKSTAEVKSSLAFFDALPSDVEEVTVDHVYDGDTLTIREHNRVRVRLLGIDTPELKEREPYAKEAADYVKKLCPANATVWMKVHRGDKRDRYNRLLAFIFVSNPSGGPDFLCVNIAVLERGLGTFYSPTGSHVDFRDEMLRAQQRAIQGKANMWRKRNLQKGVFSTQHGIAFHTSDCLSLQHTNPQNLQTSAVVQALSKGYSPCRNCKPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIY1</accession>
    <name>A0A088RIY1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Integral membrane transport protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_090260</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN95942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704264.1">
        <property type="nucleotide sequence ID" value="XM_010705962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIY1"/>
    <dbReference type="GeneID" id="22572596"/>
    <dbReference type="KEGG" id="lpan:LPMP_090260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090007600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_090260"/>
    <dbReference type="eggNOG" id="ENOG502QPI5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050171">
        <property type="entry name" value="MFS_Transporters"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23517:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23517">
        <property type="entry name" value="RESISTANCE PROTEIN MDTM, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="432"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="518"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="38"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="235"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN95942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="606" mass="65588" checksum="672860C182CA1787" modified="2014-11-26" version="1">MYTHVHHDGASPPLLPEHPHQFLGNYFSITYTELFKAHVLDVHLPNMLIGISASIEVPLVTFLGRRIGASYSSIADYISVVALYRTLLDIPFGIIVEYVGVRNVMFLCLLLNIAASLVGLNVSNSASLLAFCVLSGISLGGFFLARHIFVAGITSKKYRGLLMAILSGLLRWAHVIGPVSSGLFAAYWGDVRYSFVVSAAASGIAFIALAIATWSTRYQQVCGRTCTTSLAPSVTETPLHSEQDEDTLNVVRHHPGDSGRNNTYVATPLLPPPLMASTITSSGGASNLSDLTDHRVIVGAEMCVTMSPPLLHHLHHTHANSSVRTQPCSNSVASTAAASVHPSAGPWQEHYFHPATLWSTFVDYWSVIWRLGLYIVLVTALRANRKLLISFAGIRAAMTDAQVSYLVGFSFVFDALLFPLGGLMMDLLGRQFAMIPTVVGLSIVFMFLPLCRTEGQLYIAASAFGIVDALGCGIIMTLTADRAPSRYGAPFFGIMRTVQDVGHLIGARGVSSLMRYSGFNVCCWVLTAVGFFSAMWGAYGVPSDTETLPEAPRLEQAAAVAHEWRLHKVYFYSQSSEEITSLTAVSGTATSPTMTYGTASIPHLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJ66</accession>
    <name>A0A088RJ66_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_010540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009370">
        <property type="protein sequence ID" value="AIN95154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696696.1">
        <property type="nucleotide sequence ID" value="XM_010698394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJ66"/>
    <dbReference type="GeneID" id="22571783"/>
    <dbReference type="KEGG" id="lpan:LPMP_010540"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_010005900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_010540"/>
    <dbReference type="eggNOG" id="ENOG502SITZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266829at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="710" mass="76304" checksum="8356C452BFE29714" modified="2014-11-26" version="1">MTSRANLDFFAPPLERRQCVRERMAQLRAPMYEWRRDFAESAFDAATGERRPLRRVFNPAAKEHPVAAHSVRAATRNADANAAYKEVEQSNNVPPPPPKQRWSRRQWSPQRTLGSGNAAATRAYSARPAAATVWEGAASGTTDRRHMWKQSGFTFAEDYFRKSAQVPMSQTHLGAAASEARRGVGRCGVYVPYLHDTILFCEPRQHPMKTRRSRPDGGDGTATAANELPPVHRASSAAGVVMAVTFNAAESRGWELHASMDAKRTELLSFSVSTPFQKLQQQPVAYLYAAGAERFTDDDDDDDDTPRAAGAIASGANDVNRAATAKAETCYDVVGPSIAVKQRAVAMAEGLYTDLIATRARARSAAAKTEVPTCELGYTLRPSYVQSRLRRSAARHGSSSQNVGIATIVSDCYSASLDEGMSGTTPHTTAATSPMTAHASAPRMHGHRGNGVSGPPSERTITRSPRNESITGAAPPAAIEAALTDAIAFSQCSDGTVRQGSITSAPPPALSPAELGNDMDDTEEARSPDGGGDGALPREFPTAATAGGQVEYRQSGPPPASPSQSGTNAQLRPDSHPSLSLLYRTGNSTDSPTLLRTCGDGGGSTVAGGSNYSGGEWHRGHPRHVRDAKHTPHQSPRSQRKCGYMSYDAQQQHQQSPTACRLPAESKETRVYAVRVRRLFTNADASLLKCAEPKRHAIPVMLPPDWQPNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJ67</accession>
    <name>A0A088RJ67_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">RNA-editing ligase 1, mitochondrial</fullName>
            <ecNumber evidence="2">6.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LPMP_010590</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Essential for RNA editing. RNA editing in kinetoplastid mitochondria inserts and deletes uridylates at multiple sites in pre-mRNAs as directed by guide RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + (ribonucleotide)n-3'-hydroxyl + 5'-phospho-(ribonucleotide)m = (ribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the RNA editing complex (editosome), a 1600 kDa complex composed of at least 20 proteins. Interacts with terminal uridylyltransferase MEAT1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the RNA ligase 2 family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.3" evidence="2"/>
    <dbReference type="EMBL" id="CP009370">
        <property type="protein sequence ID" value="AIN95159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696701.1">
        <property type="nucleotide sequence ID" value="XM_010698399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJ67"/>
    <dbReference type="GeneID" id="22571788"/>
    <dbReference type="KEGG" id="lpan:LPMP_010590"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_010005400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_010590"/>
    <dbReference type="eggNOG" id="ENOG502QV9S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6142248at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020023">
        <property type="term" value="C:kinetoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031019">
        <property type="term" value="C:mitochondrial mRNA editing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003972">
        <property type="term" value="F:RNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000019">
        <property type="entry name" value="Mitochondrial RNA ligase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1810:FF:000001">
        <property type="entry name" value="RNA-editing ligase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1810">
        <property type="entry name" value="RNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012647">
        <property type="entry name" value="RNA_lig_RNL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021122">
        <property type="entry name" value="RNA_ligase_dom_REL/Rnl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041948">
        <property type="entry name" value="Rnl1/2_C_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02307">
        <property type="entry name" value="RNA_lig_RNL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09414">
        <property type="entry name" value="RNA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="RNA ligase" evidence="15">
        <location>
            <begin position="35"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00061370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00065943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00071849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF09414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AIN95159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="424" mass="47441" checksum="4B93A0C2E161F9B7" modified="2014-11-26" version="1">MPLPQNQDDFSAYTEIDLPTETRIDAIRRTAIANQEWVACEKVHGTNFAIYLLNESEVRFAKRSGIMDPNENFFGYHLLIDDFTAQVRALCELLKRKYGVTGRMGRVVLHGELFGAKYTHPLVPKSAKWCVLPNKKRVPISGVEIQSEAFPQYSPELHYFAFDIKYSVSGAEEAMVLLPFDDFTEVCSQVPHLLYAKPLVRGTLDECLAFDVENFITPLPALLGLGNYPLEGNLAEGVVIRHVRRGDPAVECSGVSTIIKLRCSSFMELKHPGKQQELKATFLDTVRAGALQRMRGGKKVTVLTDAMLPKLEAAANALLLNNVSKGRLNNVLSKIGREPLLSSEVQEEDVVLMLAQDALKDFLKETDPVVLNTSLSFRKALIRSVYFAAEDLLRGEWKRIMERERASQTEIDAAIAALEKEEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJG1</accession>
    <name>A0A088RJG1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_091230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN96038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704360.1">
        <property type="nucleotide sequence ID" value="XM_010706058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJG1"/>
    <dbReference type="GeneID" id="22572693"/>
    <dbReference type="KEGG" id="lpan:LPMP_091230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090017800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_091230"/>
    <dbReference type="eggNOG" id="ENOG502SBK1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="245449at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN96038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="440" mass="47506" checksum="C3A5FC375D67D6AE" modified="2014-11-26" version="1">MPTTSHHCSSSPVASSLRPEPACVEDILSELLPFLVEAPPRCDGCPLNSSAELPAASPVLPIPQAVASEHRVQVSIRGRRYETTMEVALTYCLLFFVFFHWPFSSEDEDSAAAACAGNVASAKGPQRTVGDAVVAATATQSVTETHLLTHYTRIVEPVLRVFLDRWAAPLNTNARAQAEREKTADAETEKAGDAVQLACLPPLPRPAHITYDGATRVWKFEFAARLTAAEAAAVHARHQRSSNCAALPSAAADGSAALTNDKLNSSPFLLLQNEHMGMLLVFLRRCSKVRTERRTAAAGALPPYPPLPMRWAEMNYDEQLSFVQLLRCFGVVPLIPTYTRPTAPQTTSLYIGADAVAAAARPKGESDASSLHTHTAEFIHKQQSEMREISTAAASIAVEAPEVDKKERHIDEDGSDGLVLSAKGCARCGMAEHSTTECHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJJ5</accession>
    <name>A0A088RJJ5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_100630</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696785.1">
        <property type="nucleotide sequence ID" value="XM_010698483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJJ5"/>
    <dbReference type="GeneID" id="22572799"/>
    <dbReference type="KEGG" id="lpan:LPMP_100630"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100012800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_100630"/>
    <dbReference type="eggNOG" id="ENOG502R4Y3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="238351at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="57"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="73"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="122"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN96132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="346" mass="38925" checksum="E7BFA6E1200AE0CA" modified="2014-11-26" version="1">MKAEAAFLHAAPPMALVATLISQRQFRFPSVNLRTSPVSCSETPAPTFLRRARLATPFLPSQHPMQHRWIRVKSQEKGQQKRQEEEDRNAEETRKKGEEPNSKTNSGGEGSDRQSDSSSRGSKNKKGGKGQAKKKKSFMDHVHGLRDDYANFPHIYNSVNAINFVVFTVFCLCSTGSNTEERWWLETWGVDNSVRPWTWLLHSFLTNNFLAMTYAMMLLHTMCHQVLPTLGSRGLMMYCGGVATLSGMIMWLGNYLYYGGTAAPEQQFGPWDVIAALFVMEYAYHGVTPMAILNSFSGWIKYACWVGEICILYFDWQPTLIGTLVGLALCKGVPRFKAVKPTTKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJS8</accession>
    <name>A0A088RJS8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_041120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="AIN95434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703756.1">
        <property type="nucleotide sequence ID" value="XM_010705454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJS8"/>
    <dbReference type="GeneID" id="22572071"/>
    <dbReference type="KEGG" id="lpan:LPMP_041120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040018500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_041120"/>
    <dbReference type="eggNOG" id="ENOG502SGC8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052514">
        <property type="entry name" value="SAM-dependent_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34203:SF13">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34203">
        <property type="entry name" value="METHYLTRANSFERASE, FKBM FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001838978" evidence="2">
        <location>
            <begin position="21"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase FkbM" evidence="3">
        <location>
            <begin position="251"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN95434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="353" mass="39501" checksum="E3E7BB5D90E1F45E" modified="2014-11-26" version="1">MAFMLLTGFLGAYIALCVWAHQCVLRTGQLAKRTQQFTDASGCARSVEYKTICGDWGTAMVVREIFKDMVYTRHGIDIPVTGSPLVIDVGCNIGLFSMFVLEVNPHAVVVAAEPIPWLCALAKENTARYGQQVWVEQVGISAASLSDAEFLVDPRVMAGASMYETEITRAWKDAALCRQLSVVGRDNVTAGNLPAQPTLLLCSLLEMPVLQWLVTLLLMPALVLFVIFLLLSPSKRRHVRCDCVPFAELLERSTLHMPDVAMRRRITDGPIALVKVDVEGAEWDVLLGIADSEWRRIEQIVIEVHDVQNRVRRVEQLLRAKGFQEVHIAQEEWVSHNVLRIHSVFARRTKTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RK49</accession>
    <name>A0A088RK49_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_110990</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696946.1">
        <property type="nucleotide sequence ID" value="XM_010698644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RK49"/>
    <dbReference type="GeneID" id="22572964"/>
    <dbReference type="KEGG" id="lpan:LPMP_110990"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_110013700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_110990"/>
    <dbReference type="eggNOG" id="ENOG502S95N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="74807at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21437">
        <property type="entry name" value="zf-HIT_ZNHIT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039723">
        <property type="entry name" value="Vps71/ZNHIT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13093">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="5">
        <location>
            <begin position="442"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="135"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN96293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="483" mass="51196" checksum="4AAFC99864707131" modified="2014-11-26" version="1">MNRACSGGRSAAQLQRLARLSDDNAFMDVEALLKRIGGEGAWEGTAGDGGGTFDGTASPIIGLPCSSGGGSAFGATAAAAGSRRGQARKGTRASEDALLKGARIPLTASLQDQHKAYLESVRAAAKEWEMSWVGSGDDESAASSVDEDGKGVGSSKGVQAAERHGFGLKARRGGPPAKLTSEEALSPTSTPSSGPSSKLVTVTSVRRSLADGTGVPRKRPRGAQRASCDTAETEAERNVDNAVHLARPDPCSSLIAKLKAELRLVRQWERTMLECPPQIINGVLSPESRAPWVQATSTSRKADAATSSGEAKYIDDDDDTEVLPYPLLQVYCLCPSYEALTAGPVHRRDVVRCATTEESQGHEGKPRRSLALTSPMPAEAFTRIVHVAGFTFAVPGHAFAQRKRRGRRNQKSSSYAGGLASGGQVDFMDPGSEDAVQGERQHHLCSVCMLPASYRCLRCRTALFCSIDCHVLHDATRCLKFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RK94</accession>
    <name>A0A088RK94_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine zipper transcription factor-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_060230</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Self-associates. Interacts with BBS9; the interaction mediates the association of LZTL1 with the BBsome complex and regulates BBSome ciliary trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LZTFL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703906.1">
        <property type="nucleotide sequence ID" value="XM_010705604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RK94"/>
    <dbReference type="GeneID" id="22572229"/>
    <dbReference type="KEGG" id="lpan:LPMP_060230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060007800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_060230"/>
    <dbReference type="eggNOG" id="ENOG502R9NP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="313412at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903565">
        <property type="term" value="P:negative regulation of protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026157">
        <property type="entry name" value="LZTFL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21635">
        <property type="entry name" value="LEUCINE ZIPPER TRANSCRIPTION FACTOR LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21635:SF0">
        <property type="entry name" value="LEUCINE ZIPPER TRANSCRIPTION FACTOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="147"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN95584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="278" mass="30811" checksum="BEB9F35F81BBCD11" modified="2014-11-26" version="1">MDLFSGLTSESRNAIDDFFRWSRLSLDKFKRDLAVEASAFQSGNLWREQYTKEEVSQMLNGQLALVLGVVDTQMEGTTAASAELMRAVLREGDRQRLTLSIDVRAVLNNAGGVNAMGEHGRQLMSGPTGRLAPLTLAEAGGEAARQLAEANAEVRRLQMKLQQVTDAYTQVMSGRSSDTANLLSMQDAMNDKERLAAELARRCQGQDTSLATVVQELRSEVAEAKRELATRLHQSTQYQQVKRLLAQRNEQLKAMRERLTAYDPSFAHCGDDIAAEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLF9</accession>
    <name>A0A088RLF9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_160110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN96887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697540.1">
        <property type="nucleotide sequence ID" value="XM_010699238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLF9"/>
    <dbReference type="GeneID" id="22573588"/>
    <dbReference type="KEGG" id="lpan:LPMP_160110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160006000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_160110"/>
    <dbReference type="eggNOG" id="KOG0231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270720at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215:SF14">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="419"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="558"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="593"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="668"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="698" mass="78000" checksum="DAFA0F15D5250B24" modified="2014-11-26" version="1">MSTEPAFDASHTDFMGYNLAPDFATVVEASERTGVGYMQYSNGVIYEGDWLNGERHGLGVCYYPSGNIFVGQFRSGMMEGIGTMFFATGECFSGEFRQSSIYKGVYSCRGDEICGTWKDGKRVSEMPTKAPEVLQRARAALFSTIVEQVNMYLWQAASNPTKMVLPASPEDKILLPPLDIVSSNADAYAAPATSLQHLVATPNFRVGGQSFVSTRICNNSIGEGDTTDGLRGVTTEYGSPNTVFTCAAPSPGEIFFIWRFTQRCFVFLFPFLSLPWMPVAPLRITSLHEEREFVVSGAALRSDFDAPSFSICVIAVAMMCHITSIVIVATRVPLGHVQDGRLTLPEMVVPCVLWLVVALVGASYISFFRFPHGLERVDRRLTPKLSALAASLVDAKASVCIFTYDDNGRGKVMNRHYKYRWLLFAVVLGSMMSLSAPATRGGYGHQLFGSEAFEKAAAVLAFFATFLFSTTLTFLVLKITDMQREVRAKLHVMTNLAFLERRCLISPSKHMNMAFHLDERFDATNLFSGFPGWYSLRSLILYASACANHRARRTAMGIFWFVLVCAFIVGLLDIFYIAPRRPTPGNRYYSTAHSYALFTFLFWGALLHRYLYVCVSTRRELRQHLYIIDITGLYQRVKLDDSEASEIIQQCSRITERNDAEPEIFPQVIYNFVVVLTVLLNMGALAAICYQLRQAIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLI3</accession>
    <name>A0A088RLI3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_091400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN96054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704376.1">
        <property type="nucleotide sequence ID" value="XM_010706074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLI3"/>
    <dbReference type="GeneID" id="22572710"/>
    <dbReference type="KEGG" id="lpan:LPMP_091400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090019500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_091400"/>
    <dbReference type="eggNOG" id="ENOG502SIYZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272853at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="337"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN96054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="531" mass="58320" checksum="3A35844574FAA927" modified="2014-11-26" version="1">MQRRRIRHHLRFVDRYIVFAVLGVVAYILVINLVAECLAIGIRDRTKTAVSSREASRVSDVVPDEVFWPHRWPVAPIAEVHIIKEAMEYVTQSLTKAIPFTKHLPEAQLAVWDLMLLTGVRTDLTPAVKDLKAVAKAALSTATGAASSETFVAVREALESAAVVWSMKGKTAEADEVRKVLMDIAAVPTPGATADTTSWSAFAREVWSRVAAGGASSTPDGILETYNTLRNASQSYWHPGEQAAAVPPLYNSKLLPLRAGTYDAVVPLARLFLQLWVLGGQRKADQRLVETYDAAVASILRDLLYTRTVTAEAQAVNFTFVGSRAELLVPVATPRMCALGGVLAQGVRYGAHRYPARPSTAQYSENDVLQAAEALTTSCFQLYAEPAGHKLRSAVYVTDSGRVPGYTHAGNGGGTASLRSSYCDIPAVLLESFYELYQTTHDPMYGLWAILVMRQDTSDHCGLRKTDVTSATLWRRHIRELRSLWLLFHHMECLVYRRSRGSRAMCELATTTMVSPVTGHIVPVPYMSATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLL7</accession>
    <name>A0A088RLL7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leucine-rich repeat protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_100150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696737.1">
        <property type="nucleotide sequence ID" value="XM_010698435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLL7"/>
    <dbReference type="GeneID" id="22572751"/>
    <dbReference type="KEGG" id="lpan:LPMP_100150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100006700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_100150"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="236" mass="27079" checksum="289837E24081B49D" modified="2014-11-26" version="1">MVYPTYPSYSPLVEMDTAEVEMQRVLEEGSNTLYFSHHFNCTDVPPSIAALREQLEVLHVDNNYRFTTISPRVTALSKLRWLNASYCSLRSVDSSISRLSKLERLTLNNNMLTWLPLEMWQLKALEELHIGNNHLHVLPGCLLFLPRLRVLTLENNPLYTPEEVKGAAAATYVPAQRSVDCSACCIHSRYYEVFVAFHAIASHRDVPFVHFACSDECAAHVRTRLEAYDRDHLNRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLX1</accession>
    <name>A0A088RLX1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Solanesyl-diphosphate synthase, putative</fullName>
            <ecNumber evidence="8">2.5.1.85</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_151030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.85" evidence="8"/>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697478.1">
        <property type="nucleotide sequence ID" value="XM_010699176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLX1"/>
    <dbReference type="GeneID" id="22573523"/>
    <dbReference type="KEGG" id="lpan:LPMP_151030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150015500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_151030"/>
    <dbReference type="eggNOG" id="KOG0776">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9927103at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052924">
        <property type="term" value="F:all-trans-nonaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000002">
        <property type="entry name" value="Octaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF69">
        <property type="entry name" value="ALL TRANS-POLYPRENYL-DIPHOSPHATE SYNTHASE PDSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN96825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="359" mass="39376" checksum="7AC3EAF916C3B719" modified="2014-11-26" version="1">MLHRSLGWLCTAAQTQGSKALTSEGRPFALVHREITAVREHIHSLVANTNNEVLDHAGKYALAAGGKLMRPALVALMAHAMLPLDVSARLLEEPIGSLDEVTPGTILPFLRLAEVTELIHTASLVHDDVIDSSDMRRGRPALHKVYDTKRAVLAGDYILARASFYIATLQVPRIVILMTTALEELMSGELLQMDGCFDIPRYEQKSFCKTASLISNSLASTAVLVDPGNEALEQTAFDFGRHLGIAFQILDDCLDITGDEKTMGKPKLADMKEGIATIPVLLVAQRNAKVDKMVRRRFSELGDVEYCLEAMEKEGAVAEAIQRADEHCRLGIESLHKLHHSPARDALANALLMVINRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMF3</accession>
    <name>A0A088RMF3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sn-1-specific diacylglycerol lipase</fullName>
            <ecNumber evidence="14">3.1.1.116</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LPMP_180160</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:33276"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="14"/>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697850.1">
        <property type="nucleotide sequence ID" value="XM_010699548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMF3"/>
    <dbReference type="GeneID" id="22573906"/>
    <dbReference type="KEGG" id="lpan:LPMP_180160"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180006700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_180160"/>
    <dbReference type="eggNOG" id="KOG2088">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="438440at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052214">
        <property type="entry name" value="DAG_Lipase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792:SF8">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="16">
        <location>
            <begin position="371"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AIN97197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="708" mass="79753" checksum="7932F827C0F5015E" modified="2014-11-26" version="1">MPSLVWFGRAWWVGSDDFVFSSAVQVILFFGSGALIASRVNTTRFNYLDDCDLASVSWGRTMIGLLCMNVVSAVLFVCTAAVSLQGGVFEVSKRKAVPLLLYIDTACITLIFVLACLGARYAIFGTETQYCTQASTRHVLRGAILIDLILFALYVAFFIVAFDPNGGHAHRSSSDYAQVWWRRFHICCCRFNKRRHMENAHADLAQVFAFAFRGYDIVPSDIAAGTLLLHGYQTCSRALLSRMVSYGPNPHGYHERISSQARPEPRLTPEQRAWAHELQQYSPFFIATYGCLLFEFQHLGTGLARLCCFNPCMCCRHQPGQHVGQGCWCDVTALLHEARIPEEDLLLTNWDNRVFKPVHYVAYDRTSDVIIIAIRGSMSIEDCVTDFAALPVTVTLCDTPHDVPISEYYAHGGMVRCAYYVLENLREHGILRQLLSGRFVGNKVVLLGHSLGAGVALILSAVLWSDYMGLRNRLRCLAYAPPGGIVSKALMEYQKDFVAAACMGYDMIPRLAQHTFESFCEAIFDVLAASDINKNLIFMNVLRTTEIAKSFHPSFLDNLQERRSAESLLFRESLQNTLYSPPCETPKLYNCSRMIHYVKVVEVCTNTWCVPGCRRYNEEVYIPVVRDFEEVQMMLASPTMLTDHFPDRFFRVMQKSMELFDKGELDRFYVDDLSDMSPPLQDASMHSVESVAATTTETGFLANYGSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMX4</accession>
    <name>A0A088RMX4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">5'-3' exonuclease, putative</fullName>
            <ecNumber evidence="11">3.1.11.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_171120</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.11.-" evidence="11"/>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697803.1">
        <property type="nucleotide sequence ID" value="XM_010699501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMX4"/>
    <dbReference type="GeneID" id="22573855"/>
    <dbReference type="KEGG" id="lpan:LPMP_171120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170017500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_171120"/>
    <dbReference type="eggNOG" id="KOG2044">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="372487at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF75">
        <property type="entry name" value="EXONUCLEASE XRNA, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="912"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="967"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1004"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="10">
        <location>
            <begin position="1048"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="473"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="829"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="476"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="491"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN97150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1108" mass="118928" checksum="DD53FA078E38E28F" modified="2014-11-26" version="1">MGVPKFAAWLRKKYPSMVMARCPGDVHGLYIDLNGLIHPCCHDEHDPSVALRTEEEKLRSICLAIETLVVTVRPQHLLYIAIDGVAPRAKMNQQRLRRYMSAAVPLADTNKTFHGDSHGISETMVAAFEEFTQAEFDEVERELEDVSQALMKDVLYGGGATMDLGDEATGEGEGADGLPVAPPTALPTVKSEGEGAACGSAAQAGRQPTAWAPPARFDSNCISPGTVFMDAVAAAVRDYIHRKLAPKANDGGDSAEVEAGSSPSSSTTINAPCAHWAGLTVVFSDSNTAGEGEHKLVDFLRTQSAFPGFNGSGCHVIAGLDADLIFLSLSLHIPRVVILRDNNQSSYEQALLSDTAGGTLMTKKVSLKAKTPQVREALVASSLTSSGTMTLATASPRHIADMVVKPCISYEYFDIDVVGSSLVSEVYQLCLENCIRIRGDLLTCAANCLAANGFCFYRYNRAGGGEDGGGADIDGTNSGAARVTSPTANKGDGKSGEKPTARPRAPPPPFHPCTSTGNSKIVDDFIVLGMLLGNDFLPHLPSVYCGESAMDTLMDVYTRAVLPYGYLTGGKCEIQLAQLERLLRAYAAVEAVRFRQFAIQSGTMTPQEAATPELCSAADRRCWRDVYVCTTSLRDEAGTQAACRSYVEGLQFVWCYYSSVSLQVNWAWYYPFHHAPLALDIADFLRAQGPQVQTTLAALELEGQPPSPFCQLLCILPPPSRQLVPEALRAAMTSPPAELVDTFPHRWVVDRTGAYGKDHLAAVLLPFANLPPLQGLVAAASGIYTAEEKQRNTLRFTHYVFKGQSAQLARRPAATSTGAVPATATAENLTNPAVSQEARAAPFSKPRRASPVRTAPPVRGSATTMMRGFRIQGSGLRALSAEEVPANMRDCTTIACFSLAEIAPPLSRPRTYSYAVPIPCLTALPYGGRVAAQRRPRHRRGVAQSCKNENACVTANNATGAQASTPAVLFGEFAVCLAAMGVLTAGATVWHSFSLRPLLRSGPILLQLCCICATVIWLAFALGLAVTPKGRSAGSGQRRHRIFTAFVDWQCSVCLSLNFSRNRRCFMCCAPYDPHRCVALFSSCHPPEPPLMDPDHSAYAECYGIPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMY7</accession>
    <name>A0A088RMY7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_171270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697818.1">
        <property type="nucleotide sequence ID" value="XM_010699516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMY7"/>
    <dbReference type="GeneID" id="22573870"/>
    <dbReference type="KEGG" id="lpan:LPMP_171270"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000012300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_171270"/>
    <dbReference type="eggNOG" id="KOG2651">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10258156at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052220">
        <property type="entry name" value="METTL25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496">
        <property type="entry name" value="CGI-41 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496:SF0">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1054" mass="114199" checksum="573A706C670BDBB6" modified="2014-11-26" version="1">MRMPASHSLALPLSADYAHNPREGFSFFRSRGSGASPAQPDAANTTALDRYLDDLCAFLHSARLIQSHPDNYFQFIRGETWAASGVHFDRSPVQAEELAYTQSLLSAFRPLLHGDGAMAKLRALVRDGPPTSAAQCVGPLTGDFHTSPASLLPASAASLAPLQEFYAATRRLMLGRARRLENDAAGFTLFTEAERLAIDRDSASAQAQRQHEHDILDFVVSLGMNAKKQHEVRIMRETIHDLVLCCNASVEQTSVARLQAEEADNGREGGGEHCSGSAAQVRSMINIGEGKGYVSRAVALCDSLQVVGLDCNPAHKERAMGCFESLLEMSLSSRDGQPRVNLLYEPRGHVASIACRVEEKVDWESLLHGHVRTCADPCCELSKRCGDGTYATTGHHAEEQGAIAEGGVVAVTRTHGDETVKLTCRVCAKVVRQESTTVIMKHVYSHLHAGTSSARASSEVGELSDAAETSALTSPRPLRIPTLAEVQQWSASLSQHAYVAKLTEHFFTLRDTEGRNPSIREGSTLLKRACVDGEGGAALHVSLSEATPGYLTLAPRAHGDVCNSTSGGQPQLPPVRLSVTLKPAYTARGYRVVLLMAVAETAASREPHLPSSAGTIGAVNGETQSAAMRPLRHGCDAEPGLISPATVHSPQLWSYTQVIATIVGYDGGAESHHVCVDQECKKRTLRLYRLPADATAASQACALQSTRRHGCRIACIGDWELPDAETWGRERVALILAVLPPVLPSTPAVYVPSVRNTVLVGLHLCGDLGSNVCRIFRNSSARGLLLVSCCWHALTPRGFPLSHALQRRGLSTNSISLLLATQPLDAWSTSSPEGHRSSAKLLFFRSLFKLLWTQLVRRWEAGRRDVSAPPTVGCAHVDPLNGGDACPFPEVPPHLEPAFLRRISRDKETLTFAQFVHAVAAEYVYAEPYKDTPYTPWSVGQYCTECRATQEAYVRHALTQERLPETMGASFEQEHFASFLGLTVLRMWMCHLVESLLLLDRTLYLHEELSKFDTHGAEAPAAGAESSAVALVPLFDGALSPRMYGVLARRGGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RN60</accession>
    <name>A0A088RN60_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Calpain-like cysteine peptidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_200050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698204.1">
        <property type="nucleotide sequence ID" value="XM_010699902.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22574212"/>
    <dbReference type="KEGG" id="lpan:LPMP_200050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200006500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_200050"/>
    <dbReference type="eggNOG" id="KOG0045">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="167576at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051297">
        <property type="entry name" value="PalB/RIM13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143:SF1">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="6">
        <location>
            <begin position="448"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN97497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1514" mass="169557" checksum="69BAFEEB04D32245" modified="2014-11-26" version="1">MSGGDNKHEPELNVPDTSDGDVRGDRPEYTGIPAVVQRPGPPKEAFLPPVRQGTHDAYENGLNSSNETARRTSGHVGTSTHLKGSVREYVRKTLQLQSEQGIRTCGRVRRPLSSILVKADAAELQRGEDSNGNQHCDSELRRGLGWDKSTDNGAFWKRTMSKQETDADLRCFTAYEYILAFYYDESRECDDSLDVTTPDSSQRRKRERVARVVAEATPREEAERSKLKSKGTISARTRRAQMTCATVNELYEQLTMCYRAAGVEKAYLDTLFMKEVLNGSRQPRVHEMEKDDDLGENLSAPSDGEAMEAPREVVFVGKAKRSKSTACSRRSAKLSSLYEILLNQMRVRTTPAFLHHNAIPVPMMRFLKKRGTIKLGNYSYVLHLWDDEEKGYLVTGVFDRKPGFPKQFKDSCTYAIYGVEMGHDWGTRFGNLVLMRQHLAPGARKHFPEEGKLIRGHTVIRAASVLDIFDGRVCDIPLSLREVDYRRTGIHASVQALAHYNHLFPHWGPLRSIIHPQDCLGRPVVNPAGGMYCLSMIVNGAVRMVKVDDRVPVEPESGLFRCLTSATFELYPALLEKGLLKANGCGVNLALMESAAVLFQLCGWIPEVIRFRRAGGVEEPTVDGLMRPSEMWSVLMEGYNVGRLMMTLTAHWCAGRLPLTPGERVRQSTQQFVTPVVYPVIDMITQRLSSTGEPTIRAIMLRDTTKDPSTRMFEPPFTTSLTAEQLLDLGYMNTHREAGIFCVTWEEAIAHFDHCSINWSPFTYWDLPSGSEPPEDCTRLCCHGVYDMRNAGQHMVRQPQFHICSHLVDRCTHLFLVFCPHTGDQPPLPHDINVLDRRAVDEFSGGEAVVRLRVYEITTLPSLMRCTMRDRRGRRVSCCFGDCQGRRIVSETEGPRGLQPLAVAQGNRSEFITLGFDCLPGTREYVVVMDVHDRHWSPSCKGAFPYTLTLFTCLDPLLERNPNKFPISAIHAQHATLEQAKQAAMGGGFSTLEVSSAELNVSDILEEEAQRKPPERTITMHDIPEHPNIHSHTVQGMWSLPESRARIALLQHDAIHELLYTGTQYYFHLGSPEHFSLRMCQSKRIGPARSTVEMKVLLVRRASRDDVDTKAKDPLVERNARTCGGAVAKGNKAYVPRSVQGNIMKGSNIVLCSGPWSLDGAVIDSVSPHTVLLDRDGILVRHPRRLRQFYHTSFNVALSDRENKDKSKMNFFFISRPNPNDQMRGVILQAFADGFLISPHACNIGIKGNLIPHDTEVRAVLTSSNFCYEVHSDEGHAVPFTEESALRSLAMPVPQLDLFIDVDLQNTAPAKSTSFSPESNAGHATNRLRAVVRTALTSSPAQRLRLLRTIFCTMMFIRRNVTNENHRAFLMGLGGSIEAWVRWHQSLESPGAQPPVLSLPPLPEGDYIIIPCFNPVSDGAAAKLGKKLGVVTEDQSMTDFDITLSVPGRVVELIPTRDSADGRSSTQVGRVQMHCEQSIASTERVSHDAAMRRFGCTFFSGWMFGEKNRCKRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNZ1</accession>
    <name>A0A088RNZ1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_203170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698519.1">
        <property type="nucleotide sequence ID" value="XM_010700217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNZ1"/>
    <dbReference type="GeneID" id="22574528"/>
    <dbReference type="KEGG" id="lpan:LPMP_203170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200037700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_203170"/>
    <dbReference type="eggNOG" id="ENOG502QWQ8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276741at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000049">
        <property type="entry name" value="ZFP family member, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21099">
        <property type="entry name" value="RAD201"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21099:SF2">
        <property type="entry name" value="SI:CH211-113E8.11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="7">
        <location>
            <begin position="220"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN97812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="475" mass="53754" checksum="A9885C99D123095B" modified="2014-11-26" version="1">MFGGGEEYFQDPPEIDRDTLVRYATFCARLRAIEKPGKKTITEAAALAREVGDTLLDYELVVGALFRHIKTWTGQKQLACWYVLDKLCKEDRDKYGYIAGKYILEVGRDHIPYEDPELTGKYETLVEHWENVFPRHVVDALWIAKKERLWAVDHPNEVKQQQQAEEEEWAREEVAMQDEDGLNDFGQPCVDYLQGHCSWGDNCRLYHPPGEEGSLPAECRMGDWKCSACGVINRHFRRRCSNCVREKPQYKKGRVPSAEDQLLCTPDPGVATAFHQQFGYNPYVPAEAIAHFKLRLEGVSAEEYRKERAAAYRVRILGRAPINPVEERCKASKHFPDIDMEPYEEYEVGTDGLVVKRQRTESLVPANASANSAVTLIAQLVMERGMLDPTVPLLFGELSRCIRQAAGDPTMVLNETQAEVLLSACKLGFTAWNANKGAVPFVATFFKAVRHNEGKLGLSGEQVEQLESMANMFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RP16</accession>
    <name>A0A088RP16_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_161290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN97004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697657.1">
        <property type="nucleotide sequence ID" value="XM_010699355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RP16"/>
    <dbReference type="GeneID" id="22573708"/>
    <dbReference type="KEGG" id="lpan:LPMP_161290"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160018200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_161290"/>
    <dbReference type="eggNOG" id="ENOG502QVPJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051341">
        <property type="entry name" value="Zyg-11_UBL_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12904">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12904:SF23">
        <property type="entry name" value="PROTEIN ZER-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="477"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1247" mass="133546" checksum="3172CF2E017D606C" modified="2014-11-26" version="1">MQDALKKFNARVLEENEKEEARKNRHNSRSNSWDSLMVALPVAHSPLSVVSASPPKHNPLHTPPSRDNSRSASSSSGGMVPTTLTSAASLPPRVTTVSQISPKPSSPRSNRVTTTTTSSNHSSSSVPASVPRGSANSSENGTTLHTTPSSPFFAQGLRCGLPRTVKLEQQQLGSARILQAAASQSHMRLSPTSSSRDEVNTPPIVDTPRPAKTVVGKPQIEAPRLPPSPRTASPAISNLPGRYVQVSSADEQKNSQSTVENPLIGPMPLMPSPSLVVGPVYSAVEIQESTSLSTGSSNGRWGPSSDAKRPSVSSSNGGQAGADKTIITTTPGVSRATTLQPMRQPTQPVLRKNHRIDELNYIREEAPAEQSSATLSHNTPGASPLTSSPSSSASQNCGASNGRPPVSPSRSDEPHDAGSHRLSHANSNGSDDSSPVTELPLFSSTDERPGKCSPNSAAAKETVATITAPKSPKFINSSPAAGQSPSSAASTKVPPLANGSSGGSLTQCPGSALNHSGRYSPARGNPNASTSAGRHANDQHQSSAGTSIPDDDAETAALSSYLMEEDLNLSLSTFNRIGSTLAQSLTLRVLNLKGSTISSEGLRGLADISTLKSIGVSHMRYLTTLAPLVTPTARANGRHCGIEEIDAQFSPLTNEGIGGLEKLRWLRRLDLSMTPISDVTGLAASHSLKDLYLNGTRVDSPGLAGLEQLPMLSLLNIARTKVTSLKQVAKSRSIQTLIAYSCQITDDGFIGVGEMPRLSTLDVSTTKVTNLSVLQKSPSLKSLRAQWLSLKNCHDIIQQRRAQMDGLTPDNSVAWRDTEAGFAGLANIPTLESLDMSFNTIRSLHSLCRSKSLKRLLLRRTRVDNDGIGGIAQLAGTLETLVITNLTDILDENDETEASAALNGASGLLSSIGDIHSMHRLTSIDLSFTDVYDLRLLQDLRTLRELVIVETLVTVDGLRGIEKIPTLETLDISQTSILSLQFLASGAPALKSILVKSNRNVRGFKLGHIDELRALQHLDVSDTVVEDIEAALKSAWRLKKLVWRWKDRRDSKGPAPALECWVTSPRLARMNTMPCLTTLDLTNSSVHDLAFLERSTSLTTLYLKCCRLLCNSAVQSLGTLPGLEVLELTDNRHISDVTCLRTCRRLRELHLNHTHVTKAGLKGVTDLPELKVLDIANTRAEDDVKDEDVNGAMERSRLLEDSNLREGSTLLDSSAAPAQFRVPRRRRVSFVASDGSEAVPRKPDRCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPH4</accession>
    <name>A0A088RPH4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_201960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698397.1">
        <property type="nucleotide sequence ID" value="XM_010700095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPH4"/>
    <dbReference type="GeneID" id="22574405"/>
    <dbReference type="KEGG" id="lpan:LPMP_201960"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200025000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201960"/>
    <dbReference type="eggNOG" id="ENOG502RZF7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="247089at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="644"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="752" mass="81033" checksum="0DD774E98A11386A" modified="2014-11-26" version="1">MATPAEVDPMVALVESWDTYLVPSSRLHSSMEWPAQDCPRIAQSTRAFASEPSVFRYHLNDACPIFTPGEQDNTDQVSLATSGPPSAGAPANGATEFSASSLLWLLTLVSRNAELLRATAHLFLQFNAQFAALVDSNAMTVNALRTRHQQQLASLLEMTDKYTAEDMIVDSVVTERVILQQQEELDTLERHCAAEEKQLEADLQVTLWRFLTTSAPDAVAAANRKEQSLSLANGDHGAGVGGSPYRPEADVSRFAEVRKTTTLHARRSSTAVAPFWPVHLVPVRTIKLRNEVSDAFAASAVSSTRSPSRRLKDSALQPIILDISPVSGLPRCLECCTGTQPGAIASTVWSAAEEHLLRLAHTRHSVLLFVGSELAALDLMQKCRAPELLLGTGHSCCDVFQRLANHPVLQVLFTTRLWGANVVLLWNPAQDVAPAAETQTVVEDALELAYAWGADMFSVAVLEGARLPSYAATGCFTAMVTRASSTSAAFLASQAVSMEVLRQLRNGVTRELLDTAGARRARRWQGTATWMPNGIGSAAAAMTGTRMCPRAVGVLYTSQSAQQEQENQLKVRQVSCAGSSDKPNAAPPLRKDNSIVSVNSSSFLFMPTSSPSSFRGPCITFNTPLAIRAFLPLGEEYFISERSSRGRGCSRSGFDASSLNIPNHERGDAHGLLRRPVSSTATEDDDASFSNKKDAGFLYESSSATSVRASSAALDAVEAGSRGGEVGLRQSSEVMTLESLIQHTFGDFAEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQB5</accession>
    <name>A0A088RQB5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_220020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699004.1">
        <property type="nucleotide sequence ID" value="XM_010700702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQB5"/>
    <dbReference type="GeneID" id="22575048"/>
    <dbReference type="KEGG" id="lpan:LPMP_220020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220005200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_220020"/>
    <dbReference type="eggNOG" id="ENOG502SMVG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275105at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="145" mass="15902" checksum="83EED8E2D9B7DD6D" modified="2014-11-26" version="1">MAEIEPSAVPAVVVLDCKEVGVTINLQSPPTASNFLGYNRMCAMLDSDYLMQPINEAQYDSETQACVDRVTNGPTSFYDHYVRKPTRKRGLAVGCESPMEHVAMNEDLLMPPTQRDLPAAGVEAGAFSDPLTRRLATGRMPLHEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQY9</accession>
    <name>A0A088RQY9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_230770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699234.1">
        <property type="nucleotide sequence ID" value="XM_010700932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQY9"/>
    <dbReference type="GeneID" id="22575281"/>
    <dbReference type="KEGG" id="lpan:LPMP_230770"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_110008400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_230770"/>
    <dbReference type="eggNOG" id="ENOG502SCW6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267957at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="514" mass="53207" checksum="AEA1A65B7E10F7F0" modified="2014-11-26" version="1">MSRRHHLLSRREVIALFLDFDDATVNLTDMALPAPPQALASSGGVAASAYLPPFTRLDVVREALVAFVCVKLRSVPSTALLTFGLYVVRADSAKAEGQDNGEVAVEELLAPGPAGEAGSCAVQAAIKDLDPSVWGPSNGDQSSFASSSPMVYTGVMRCLKRLLEEAEQAQQQSPDQAAMRMSKSASVAAFAKSPSAGTKGTRASLTSSWSPAPLSTSLARRGPPATATAGNPEACAVVHGIVLRSRLTPPVPPSSYAQGKASTTLCNTDGTTTTTTPRCWLDIVSLAPLGNGPPTELSCFSNTSSSVAAAVPYEHTPLLFTELNANDSCTCALLDPVELTGISHRGLALGPALTRLISLQERRTGSFVHRSLAVVDIFACATASADPGSVFLLDHAASNDSVGATSQQQSSISPKLCIPTAAAKSFTAQLAIPPQSLGSSVAGPCSALPSLLAIQASNGNTSSAQPLRILTPVGTTHHSLPAVIEQRSIASAARLPRQPNPRRPKAKTVVPLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RR84</accession>
    <name>A0A088RR84_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonucleoside-diphosphate reductase small chain, putative</fullName>
            <ecNumber evidence="3">1.17.4.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_221170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="3"/>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699117.1">
        <property type="nucleotide sequence ID" value="XM_010700815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RR84"/>
    <dbReference type="GeneID" id="22575163"/>
    <dbReference type="KEGG" id="lpan:LPMP_221170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220015100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_221170"/>
    <dbReference type="eggNOG" id="KOG1567">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10248373at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030475">
        <property type="entry name" value="RNR_small_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF18">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00368">
        <property type="entry name" value="RIBORED_SMALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="392" mass="44316" checksum="704B8B50D7B16647" modified="2014-11-26" version="1">MAGELKAIAEGAAPAKRVRTEEAETGVERPSGEAARVSSPSTAEDLVIKPIATGAEVLLADKVAEGTNAEEEPLQQENPFRYVLFPIQYHDIWRKYKEQESCIWTVEEIDLGNDMKDWVALNDGERHFIKHVLAFFAGSDGIVVENLAQRFMSDVKVPEARAFYGFQLMMENIHSETYSVLLDTYITDSEEKLRLLHAIQTIPCIQKKAEWAVRWIGSSASFQERLIGFAAVEGIFFSGSFCALFWLKKRGLMPGLTFSNELISRDEGLHTDFACLLYNSHIKHKLPRERVLEIIVDAVNIEREFICDALPVRLIGMNAELMAQYIEFVADRLLVSLGEEKHYNATQPFDFMEMISLQGKTNFFEKKVGEYQKAGVMSAEGTSKKFSLSEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRX6</accession>
    <name>A0A088RRX6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_250270</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
            <location evidence="2 10">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the dynein light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699599.1">
        <property type="nucleotide sequence ID" value="XM_010701297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRX6"/>
    <dbReference type="GeneID" id="22575675"/>
    <dbReference type="KEGG" id="lpan:LPMP_250270"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250007800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_250270"/>
    <dbReference type="eggNOG" id="KOG3430">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10033309at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21452">
        <property type="entry name" value="DLC-like_DYNLL1_DYNLL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000005">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF40">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0243">Dynein</keyword>
    <keyword evidence="5 10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN98892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="89" mass="10387" checksum="8285676299C76354" modified="2014-11-26" version="1">MSERKTDIKLADISPEMQADAVEISTKAIKEHHLEKDMAAHIKREFDKRYFPTWHCIVGRHFGADVEHEAKNFIYLHVGQLSVLLWKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RS52</accession>
    <name>A0A088RS52_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GTPase activation protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_205730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN98064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698771.1">
        <property type="nucleotide sequence ID" value="XM_010700469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RS52"/>
    <dbReference type="GeneID" id="22574785"/>
    <dbReference type="KEGG" id="lpan:LPMP_205730"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200064600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_205730"/>
    <dbReference type="eggNOG" id="KOG2595">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="206700at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045913">
        <property type="entry name" value="TBC20/Gyp8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913:SF7">
        <property type="entry name" value="RE60063P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 20/GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="209"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="106"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN98064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="555" mass="63083" checksum="683BCDB12C925580" modified="2014-11-26" version="1">MLCRSGRLKRHGKLRAMVWRDVVMGCKAVAAVPQLSDGIIRQLQEETRLQANQGGDSHSRENTHMSDSMDSFISPMAEMEDDNVDGKGSPSGASEVKRHKDDDVNNDSSLPRSSASVGTDQALSPVLASTRRHRHPSLSPPRPMPSAEQMEEAADGFGRTGGESPLVLAQVRRRAVSQLSRRVKSDAVHFLELTKDGVSSHNVTPAQNLSGSVLWPISWYHLPDNCQPRVVEADIERSLWTLYPHSAERNEQRRRLKNTILRVLLHNPERFYYQGLHELMGYMMYVLSPYMEREEVVSVCERLLVTRWKRFSAHQLRNSEAMLYATHAIIAQVDPPLATALEWCRVGPESHYAVSWVITWYVHNIENLEVLARLFDYLMVDVEGSAVIYFTAALVISQREIIFEWIHDAKEAMGISMFPTEVSDDGIMLMARVYAQLSRLPSNVLNSIDEDTLNTLVEQAEQYCTQHRHTAQQEEQNFLNGDVKNLGLLSNQRTRNAALRLLWHFLPREWRSPAKSERVRRVLWTSLMVAAAAMVVATATVDLKPGRWIHDLLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RS86</accession>
    <name>A0A088RS86_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_241070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699447.1">
        <property type="nucleotide sequence ID" value="XM_010701145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RS86"/>
    <dbReference type="GeneID" id="22575516"/>
    <dbReference type="KEGG" id="lpan:LPMP_241070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240016700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_241070"/>
    <dbReference type="eggNOG" id="ENOG502QQ32">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="278432at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42253:SF2">
        <property type="entry name" value="HYPOTHETICAL PREDICTED MULTIPASS TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42253">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="452"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="580" mass="63708" checksum="6964266F4550EFFC" modified="2014-11-26" version="1">MCDATVSFFQRGWQATKEELHRTIDNIRSTKLNLTLLFAVFCVLFVIVGNVILLIAMNFWIAQFPSDALEHNSSQIAIQVVTMLLLVFLFSAMASVFAVFYGALPLWHVLADRNRVGGPWYRLFLLFASGASNGISSVLAVYAMTYTPEFIQAVLLCCIPFSAQAWTVIFIPTERKRDYLSLCFVASFLLFVAGVLLSSLSAFLHPNEQGEKASWAWALIYLASSILFGLWCVVQRLYLDAVARKVPLEAEGKAAAQDGAPGAPRCAKSRENSSRSAIVEVDDSPHRWRATMEETGRHGPQCGKLRDESHTEEPDVGMISATTTGASHLAHGSPATDTVPQCTKTDAGVAVGAACAEAGPRFSDMESDNEMPLSPSAELLVKRHWGSQNVDDNAAKVMLLVVGLLFQLLVSFIMFPVDAIPWFGTSSSVLHAWEGFRNSIDFIFASWIHARHGLLLTLGFAMSFVGCTYLNEHSPTLASVVLQLAGPITSLVIIIIPQWNVYQDSSSVGHKVGGVILLLIAALLYHLWEQQSLRVLLAKAEEAKRRRERAATDGAEATEERLIDRDDRATHEAPSEFACR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSA7</accession>
    <name>A0A088RSA7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_241370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699477.1">
        <property type="nucleotide sequence ID" value="XM_010701175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSA7"/>
    <dbReference type="GeneID" id="22575546"/>
    <dbReference type="KEGG" id="lpan:LPMP_241370"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240021000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_241370"/>
    <dbReference type="eggNOG" id="ENOG502S57H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272558at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839063" evidence="2">
        <location>
            <begin position="36"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="916"/>
            <end position="942"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="953" mass="99665" checksum="7996A54F757071F8" modified="2014-11-26" version="1">MPQDRRPAATVGVAAALLWHLTVVCWLGWVPVTSAAAVAQAAWLDQLQPVHQGQVVTPPPYNTEVQDFLAPTLAMGLGPMGDGVYVSTTSSSTNASALLVCARAAVEAMIAPVTVTTVDALFYSLTDVSGKLDVNHGCYMANTHENLPQCVATLTSIAADCGGVAVDAVGPHLSDAASSADHDSTSSSALSGVWPSSAAMLAAYVRDWGQQRLRLERSLRRTREAAAAFARVHACVHNAATVPSSEEETRLLRARATAQVAEIASAAYSRVMDKYYIFDEWIGPSLGIAPGGGSGDGNSSDSGRGPHSAVGPDIAKCPVDTYVRLLLWGNESLSTVLLELMGTTLATADLVHTKVLQPAVRGLECMQVLTALALMVLEDESVRTVSAVLSLGKLTSTSVWSLDEFAMLTPGYNDALRQRQLWSLAYAFAAVADPAVAHELVGGTDIAECMRRAGLVVPDNITGTVPPSLYWCFYGTSMSEMMQSSVRQRSLAIRESSGAADPNGQCLWGLSVWDGLCGGATFDPARCESCPPGSVGDGEGHCVCGDASAMYVTLTDGCVAKGSAHNTPGVRVIQAGGSSPVPLSGNNASIPLFSVQLPQTAALFDPSAYLRVDVVCNGSSRGGGGTRLVATPFGDRRASCASVVAYERQHERTGVMHTLDSGTQRFITYAENLTISVTSTSAFYGETCSMTVSVGSTLHRSSISVNAGTWTFLPGAPPLNLTAHSYPRDPVASGITSAELLPGCADILRAFSESGVLNAVHVGVCRAPGEQLGVFVAPGGYSLFGPSTQQVVGARVRRSAGAAQDAAFTSSVQSLAARTGMEVSLEGSGAAADVLWSASLYPRVTPLAVNAWHFGWYANVSVYTLRRARSLRVRLADTVEASAFASVEEMVPFRYDDGQGGAVTALIADEGYGSGYVAAIVISSVVLAALLALLGVLFYLLLMTDAWPKQLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSP0</accession>
    <name>A0A088RSP0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquitin binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_251300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699700.1">
        <property type="nucleotide sequence ID" value="XM_010701398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSP0"/>
    <dbReference type="GeneID" id="22575778"/>
    <dbReference type="KEGG" id="lpan:LPMP_251300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250018700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_251300"/>
    <dbReference type="eggNOG" id="ENOG502S04I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251089at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000121">
        <property type="entry name" value="NPL4 family, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016563">
        <property type="entry name" value="Npl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007717">
        <property type="entry name" value="NPL4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710:SF0">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05021">
        <property type="entry name" value="NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear pore localisation protein NPL4 C-terminal" evidence="1">
        <location>
            <begin position="118"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="427" mass="47641" checksum="3AA9AED8A3AD774A" modified="2014-11-26" version="1">MSSRDSLLLLREEQRRRFETAKKAGTTPEVRKCNACQQPPYSASVCPASGLFHDLDKKRLIGGTVVTSNVISSSQLMAAIDQTRVRWVPSRTQLVKVDAQSINIFQSFVAQMDWKLQRYAVLYGLYDDTTHTIEVHAVYEPEQHGSTYAFDPLPDAHMDKVEKIAKALGLRRVGVACTHPMRDPEHILLNYRELLLCTKEQSRYGDECALLTVAPAAMPSTESSGNTSAPGELLTDSAAAVSGATRESTIVVSCQAWQTSPQCVHLYRLGVLQKPPGGEEALQDAEKARQVHCTMPLEVAQTETDPSGHRRFVTKSPSTEIDTRWFTSYIAVQQFMSPIVRGAFMRLSRPGMPPPALQNLRNYMNDPKRKGMSFAERIADFHVLVYLLTHIFTTDDELRALCSVARTKMMTEEAANYQAILQGMMPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSR9</accession>
    <name>A0A088RSR9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tubulin gamma chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_250980</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699667.1">
        <property type="nucleotide sequence ID" value="XM_010701365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSR9"/>
    <dbReference type="GeneID" id="22575746"/>
    <dbReference type="KEGG" id="lpan:LPMP_250980"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250015800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_250980"/>
    <dbReference type="eggNOG" id="KOG1374">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10249382at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02188">
        <property type="entry name" value="gamma_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000004">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000018">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000012">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002454">
        <property type="entry name" value="Gamma_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01164">
        <property type="entry name" value="GAMMATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="11">
        <location>
            <begin position="48"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="12">
        <location>
            <begin position="251"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIN98960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="447" mass="50045" checksum="46CBE2556E33D47D" modified="2014-11-26" version="1">MPREIITIQAGQCGNQVGSEFWRQLCLEHGIRLDGVVEPYAVGGEDRKDVFFYQADDDHYVPRALLVDLEPRVINAVQRGSMQKLFNTENIFIHKEGGGAGNNWSHGYELGDQVQETLFDMIEREAENSDSLEGFVLTHSIAGGTGSGMGSYLLENLNDKFPKKLIQTYSVFPNQSRGGESDVIVQPYNSLLAVKRLTLHADCVVVLDNTALNRIVTDNLHIASPTVEQMNGLVSTVMAASTATLRYPGYMNNDLMSMLASLIPTPRCHFVCTGYTPTTLDTSNIQSSVRKTSVHDVMRRLLMPKNMMVSTSMKSGCYISLLNLIQGDVDPAQVHRSLERIRERSPTFIPWGPASIQVILSKKSPYVDTRHRVSGLVMANHTSIHTLFHRTLKQFDMLFGRGVFLDQYRKYGPTKDSLDEFSDARDVVESLVAEYKACESSDYIRNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RT42</accession>
    <name>A0A088RT42_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Farnesyl pyrophosphate synthase</fullName>
            <ecNumber evidence="6">2.5.1.1</ecNumber>
            <ecNumber evidence="6">2.5.1.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FPPS</name>
        <name evidence="6" type="ORF">LPMP_221240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.1" evidence="6"/>
    <dbReference type="EC" id="2.5.1.10" evidence="6"/>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699126.1">
        <property type="nucleotide sequence ID" value="XM_010700824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RT42"/>
    <dbReference type="GeneID" id="22575170"/>
    <dbReference type="KEGG" id="lpan:LPMP_221240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220016100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_221240"/>
    <dbReference type="eggNOG" id="KOG0711">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10257492at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:(2E,6E)-farnesyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045337">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000033">
        <property type="entry name" value="Farnesyl pyrophosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039702">
        <property type="entry name" value="FPS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525:SF0">
        <property type="entry name" value="FARNESYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525">
        <property type="entry name" value="FARNESYL-PYROPHOSPHATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01017">
        <property type="entry name" value="Polyprenyl_Transferase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN98419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="362" mass="41117" checksum="559AFBB27D7C5B06" modified="2014-11-26" version="1">MTHMERFQRVYEEVQGFLLSDAEKRFEMDVHRKRYLKDMMDTTCLGGKYNRGLCVVDVAEAMAKDARMDAAAMERTLHDACVCGWMIEMLQAHFLVEDDIMDNSKTRRGRPCWYLHPGVTTQVAINDGLIVLAWATQVALHYFADRPFLAEVLRVFHDVDFTTTIGQLYDVTSMVDSAKLDANVAHANTTDYVEYTPFNHRRIVVYKTAYYTYWLPLVMGLLVSGTAEKVDKEVTHKVSMVMGEYFQVQDDVMDCFTSPEKLGKIGTDIEDAKCSWLAVTFLAIAPAEKAAEFKANYGSADPAKVAVIKQLYAEQNLLARFEEYEQGIVAEVEQLIAVLEAQNAAFAASVKVLWGKTYRRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTA9</accession>
    <name>A0A088RTA9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_270070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700094.1">
        <property type="nucleotide sequence ID" value="XM_010701792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTA9"/>
    <dbReference type="GeneID" id="22576183"/>
    <dbReference type="KEGG" id="lpan:LPMP_270070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270006100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_270070"/>
    <dbReference type="eggNOG" id="ENOG502SGBN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272466at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839103" evidence="2">
        <location>
            <begin position="21"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="280" mass="31137" checksum="685643E47B2A4495" modified="2014-11-26" version="1">MARSFVFLMSILVLATAATARELHLPADIYDNAAGEWSVEVVSLCRLPLLGTVTFKNTTAVVAWQEEGAPEMRISRQSTKSSMSVSALAEFLTKDNQKLFYAVCESQENYLATSRRPVQVAGMTTTYMKTYSGVLGRSSDESTCDSVSEHTIAIQALGAPFKRSKGKEWRMQESLYVIEIIIDTRNIKGGCAGTGVSDTALANKKRSWKRRAHRTLSSSAVVSKADEITAENGIVTLRFIRRSEAHQPWFLRYYTSILFATIFITYRVVHSFFSARAAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTN1</accession>
    <name>A0A088RTN1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_231550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699311.1">
        <property type="nucleotide sequence ID" value="XM_010701009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTN1"/>
    <dbReference type="GeneID" id="22575360"/>
    <dbReference type="KEGG" id="lpan:LPMP_231550"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230023500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_231550"/>
    <dbReference type="eggNOG" id="ENOG502SGP0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273237at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="147" mass="16459" checksum="DD616F07F7ACF839" modified="2014-11-26" version="1">MVVCAFSIAFLFVTLWEVCRHVSVIQHSAVALTLIPIAFFLSNVLCTSYNVLGGTLQTFAKENAQALPQPLFYVIAAIRPLAAQAGLTDTLWMACLLFVAYGVTKVWHHLIDITRLLKASRRRLQLPELRELRRQEAAAKAKVEGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTP5</accession>
    <name>A0A088RTP5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">tRNA transglycosylase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_270030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700090.1">
        <property type="nucleotide sequence ID" value="XM_010701788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTP5"/>
    <dbReference type="GeneID" id="22576179"/>
    <dbReference type="KEGG" id="lpan:LPMP_270030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270005600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_270030"/>
    <dbReference type="eggNOG" id="KOG3909">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27601at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="entry name" value="Queuine tRNA-ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050852">
        <property type="entry name" value="Queuine_tRNA-ribosyltrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46064">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE ACCESSORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46064:SF1">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE ACCESSORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="tRNA-guanine transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-guanine(15) transglycosylase-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="336" mass="36472" checksum="077FF2E83CF19ED1" modified="2014-11-26" version="1">MDAQAPFLVIPTKRGAVPTLTPAQVNAILDPSERILSTSVFEAIDFVKPCLEAGLPMSAYCGMSGYRTVLTLRSSFHGPHASASSTDSTVAGDSEKGRAVVSFEKWREVVKATQPTLVVVVHESVPLCEPLSKRRRVATTRSERWLAKTEETSDLGYTILPSISVAGTHDSGYIDAVPRGENSYEFFQTLQALHLSPKKCTMCVAPHIPALLAAMVSNVSLIECPVPWALAEKGVALLLPVKEATGTTPQPVVPLLDLNDNVFALDINPIDEGCGCFTCKRHCRAYLHHLLTVQEMNSDILLVMHNLTQVVRLVRTYRCADAPAREALVSRVASAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTV3</accession>
    <name>A0A088RTV3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_262320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700052.1">
        <property type="nucleotide sequence ID" value="XM_010701750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTV3"/>
    <dbReference type="GeneID" id="22576135"/>
    <dbReference type="KEGG" id="lpan:LPMP_262320"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260028000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_262320"/>
    <dbReference type="eggNOG" id="ENOG502SHUH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267305at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="654"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="747"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="815"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="662"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="846" mass="87908" checksum="720D0967BE3520F0" modified="2014-11-26" version="1">MPRPNEDTGNVSTSAEVQRSISLLSHGTSSFTAQCPMLVSETLSPVPSAPSNGAAGLQHDAVADRTHVSNASAAALLSTVSALPDVRATETRLRTAQEAELSVLVRLRRLTEALVSVISASNAAGGAGVVTTAAHGGCDTEDVKALSNEGAFRASLPVLIACPSATGINGATHIQAETCLVMRCVAMPPAGLSAAAREQYTALHDTLAQYLCKSGDDSIDSACDIAASSACSPSTGILQDLQSVEQCDAIPCVLGPRVTRAVICRAGTPTALPGVAEGEAGTSTQPVARDSNAVEVHRHSRFFSEPRHCLLSPPRRSVSARRWRATGVLCDPEVSAAATGMGSGSASWGTGVPHSPLTPSHVYGSSGRLVGKGESSTAMAMVLPKFSPVWVEGSSAELAADEERAEIRVEEDDHSGEEVNGTALASPMPITSAGSAATSTRGPSPYVVRVKPCSPLYPCISPLAAHRVATVNAWEDSSQVALGGHLAQDTPTSPPPLPTLRSSPHQLSQPLSATPTSTLGDADEEGMYFPTPPTAKTHRRIESDIDVPSRLPAMGNSGRAYTGAHEASAFPITCGSTVPAASLRRLALGGCYDEVGSESPRVPQWETPMVDTSQEGVLQTVSAAHTSLLSPTPTGVVTATDILATITALPPPSSWSLLSKRTPARRTHRGGKGTGATRKANVARAEGRPMHCGARKRARGEVDEWGRIDVADEPLAAVPMAGLPSLSADVSLSTAAALNRLMCEEADSGQHSSSAPARRAESDGHQHTVLEGEHASCGYVRTREQRMEGVAQAEQVFSAVRASCRPLLSVSLQTPPRGSGANAECDDISPPLSPNTPRQFWDINFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RU92</accession>
    <name>A0A088RU92_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_271030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700192.1">
        <property type="nucleotide sequence ID" value="XM_010701890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RU92"/>
    <dbReference type="GeneID" id="22576281"/>
    <dbReference type="KEGG" id="lpan:LPMP_271030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270017500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_271030"/>
    <dbReference type="eggNOG" id="ENOG502S5ZA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277221at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="17095" checksum="B6E9AFE5086EFF71" modified="2014-11-26" version="1">MLRRCLARLEVPRPAVERRKRRSRAGAGGSKKVASRRPGIPDLPKSAGGYFFQQLRPHLPIRWQYDWRWTSLKAVWVVGWSSFICYVAYVMFFKYTDSDIAEQATQYTYVRNERGDVVDIGFKPIVDAGKRARRRADRLLDPDEWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUE7</accession>
    <name>A0A088RUE7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_271500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700237.1">
        <property type="nucleotide sequence ID" value="XM_010701935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUE7"/>
    <dbReference type="GeneID" id="22576328"/>
    <dbReference type="KEGG" id="lpan:LPMP_271500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270022000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_271500"/>
    <dbReference type="eggNOG" id="ENOG502QYQM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="313433at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40682:SF1">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_48, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40682">
        <property type="entry name" value="F5/8 TYPE C DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="585"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="382"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="690" mass="74190" checksum="2C0EBE92E20F277F" modified="2014-11-26" version="1">MSGINWALEENGAQIAEVSHEAAHVASTASHRLQLREDQLWVTGDAPQHVTVYLSASHPPLQYAGWHVWQDYLTNPRMVEIASGASPDTMSVLLVCQALPGAGTQVWKLPRAIPQEHRYVRYRIMDTFGPGPTYMNKIVLLENDPGSHYSAPSQLVERAAASMDDFLRGESVSPRPSAATVLPHMSSPASALRPAGAAGSLDRSPLPRRAPPTSVLPGAATASTPTPRGARSADVEVFIGSGLSASAHRGDCTNGSAVGRSPGETRSCSRMSQLLRDLDDDIKMLKPIKIVSPGKSLLLHMPQEPPAKSLGSGSEADASAAQQRGDNREGNADGKGDDNDEDKPTARHHNRRHHCRSSSRRRNRDDRGRRSRNKGSTQPEGSQTPQSTPMSTSPMALGGWAPPAVPSSAVELCSLHSARLGALEQAVAALNEAVQYQRDDLTMVRRVVLQQAMERRREAEQRYEETRKMSAAAAAPPPVVDADAKLLALQVAVPDQRLTHRSIMVDFPEDVLRAYVESVLDHKLQKHMKKVEAKLLQRLDKQLHDLINFLSESIETRLARLTLSTATTQGQVAMPYQPCYAGRWTPTQAGGPPTGSPSGVHSMPHGSADTVGRKVDLSDIASSPSSPKGHHYHTPLTRTDASARGPASGTAAAAAPAALPASYVAMRNLPHACRAVTGAPSVFITKRNFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUQ1</accession>
    <name>A0A088RUQ1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">tRNA (adenine(58)-N(1))-methyltransferase</fullName>
            <ecNumber evidence="2 8">2.1.1.220</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_282540</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>adenosine(58) in tRNA + S-adenosyl-L-methionine = N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10365"/>
            <dbReference type="Rhea" id="RHEA-COMP:10366"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74491"/>
            <dbReference type="EC" id="2.1.1.220"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.220" evidence="2 8"/>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700594.1">
        <property type="nucleotide sequence ID" value="XM_010702292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUQ1"/>
    <dbReference type="GeneID" id="22576699"/>
    <dbReference type="KEGG" id="lpan:LPMP_282540"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280031900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_282540"/>
    <dbReference type="eggNOG" id="KOG2915">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1925287at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160107">
        <property type="term" value="F:tRNA (adenine(58)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.20:FF:000012">
        <property type="entry name" value="tRNA (adenine(58)-N(1))-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000422">
        <property type="entry name" value="tRNA (adenine(58)-N(1))-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049470">
        <property type="entry name" value="TRM61_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133:SF2">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE CATALYTIC SUBUNIT TRMT61A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14801">
        <property type="entry name" value="TrmI-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017269">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 C-terminal" evidence="11">
        <location>
            <begin position="71"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="313"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="119"/>
            <end position="122"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR017269-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN99887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="335" mass="36597" checksum="0B14AA337BB452B6" modified="2014-11-26" version="1">MLASRGTIARDGDVVLVVHGHQNITPLVLQRGAVLHCKAGKFDHDDIIGRSLGRYVKGQNNQKSDPREPSVLILQNSADMWTQAVPHRTQIIYDTDIAVILLNLRLEPGKKVVEAGTGSGSLTHSLAKTVAPNGCVYTCDFHKQRCLEARAEFRRNGLDSHLVCSQWRDVCTTNTGAADIVDGVDADVEAMESPNTGFGVAAASVDAIFLDVPAPWAAIENVCHVLKEGGMLCTFSPCMEQTQRTAEALRAAPHHFVDIRTVEALTKFFHPVFKRARDARDRDCVKFRASLVSKGHSAYLTFARRRLGKAEQLEEGKPLEADGAEKNGMEEATTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUR5</accession>
    <name>A0A088RUR5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_282700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700609.1">
        <property type="nucleotide sequence ID" value="XM_010702307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUR5"/>
    <dbReference type="GeneID" id="22576715"/>
    <dbReference type="KEGG" id="lpan:LPMP_282700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280033500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_282700"/>
    <dbReference type="eggNOG" id="ENOG502SFXM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5945798at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="447"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="271"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="889"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="889"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="915"/>
            <end position="925"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN99902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1014" mass="109219" checksum="C248D2DB86390B89" modified="2014-11-26" version="1">MAGKTVRALHLEGGQLFEAGCFAEAARVFRGAVDRFQADRLSTKLAVEEFVKVAGNLCVCYHSAGDWHECVKAARELLAIYPIIPKAYATIGMCIVSRLLEQEAEQQAADAQSSSRMPPRSGEEVRRDARRYFVKLSDVVCTADDAHKYLCRAILLSEGALQVSVGPYVETAVRWVSEQLLSAGLSLEREYGDQVIGELSVLEESVCDAPPLLDLAPVQIERHSIGVVDATDMSSAGADGTVPEGHRVEGLPETEAGLILHAIQEGQRAAWGEAADLSSPDSSSLVAENDAAGKSTTSNPSSSIIGNTSSSGSHAPVTPPLEYFLSRRRTRVRVCHSERGGIPRGLTLARASEPFAVGQHILPVPPADLPAAAIRGAPSAARAAPLLFSTQEELVSLHVDPASLSNAESALSLTALSSSLAQTGGGGGAGLSMGGLATAELPPFLTCNACGRELNPVHLSDASPTGCPTCHGVVYCSAACAVVYRDRHDRHECALRLALQRRAAALAAMQPSTDAETLLPFGDVLAGGGWNVLDLHRRVLPLCITVYSGLRSNAPSAVEVRAQVQRGVQRRLRHALPVEVADTLAVWVNVLESTVAAPASTTGTTWSVPLLQDGENERCGDQRHNDLADAATTTSCAAAAEEPCLADHLLAIFFMVRLLAVNHAESRCSTFYMERLLLRHSCEPNCIWSDTLRGILTARFICKGEELTMALDDCFPQHWPWQIRQKWFVHHHGVPCQCARCLREGANLNHGRGMLSNEVIEQLLTADVMGHPCPTPAHKNPTQLFHLQLQKLVEESKSPQQRNVPALLCRLDEMRAEVGKYVLSSHYLLEDIRLAMLNAAETEGHLAGCVLEAQRSLLFWESHWTGAIPAKSQRLRLLPSVFDCGRRRRLHVHQQRRRPRHVGPPVATAATSAEQPHDGSSEQREGPSPPLPVPTPTEVQHGSSGADFPAALSFRVGGAGYGDHEASKARGASDAATTAAAALRMPAPLIATKDFSSGRNIIDLFYGSYQTWYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVD2</accession>
    <name>A0A088RVD2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA splicing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_282470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700587.1">
        <property type="nucleotide sequence ID" value="XM_010702285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVD2"/>
    <dbReference type="GeneID" id="22576692"/>
    <dbReference type="KEGG" id="lpan:LPMP_282470"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280031200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_282470"/>
    <dbReference type="eggNOG" id="KOG2370">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265955at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019134">
        <property type="entry name" value="Cactin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737">
        <property type="entry name" value="POLYGLUTAMINE BINDING PROTEIN 1/MARVEL MEMBRANE-ASSOCIATING DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737:SF4">
        <property type="entry name" value="SPLICING FACTOR CACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09732">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Splicing factor Cactin C-terminal" evidence="2">
        <location>
            <begin position="571"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="543"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="695" mass="77175" checksum="519B8C90E57643F8" modified="2014-11-26" version="1">MDWDRPSGKRRRTDEEEACEALGGLLRQTASRAMERVRLQRQQRGWESQLTALSSSAAAAVARSVKPMDVLVIRFCMHYLDCSTVAAPNQFVRLAQEVVTSSIERLLVPQLFSRDGSSLPALCESLVTEHTAEDIQVTVKEVSEFVEARCALGAWIADATATRGDVSEDDNDDADNYTGDYYDHSRLCDHGDGYSPLANEEGEGYEDGDGGRPPNPQQDGEGFALAATLYQACEFWVRVQAFLNSLSLHSARLHVFAMPPRYERELLLLLYAATRGGGGDDEASTETVAPGGGSASRKGKSRGDAPSSPASTTVEKVESKDSIKPEPMWDGDEDVVAQVVGVGGTDNESTEQTEALTGLRQPQQLYKASALLADVLALSRCPEVPTTTSSLPIGATSAPALVSSPSSAAAPRISAEAMQHLRGLNSNFYKMVYARLGVMVARDRLYRFDQVSAITPPELTVQQRNLQEQLIQQEQQQRYKADLMSAALGIPGQPEAGLPAAYVPDDAYYEKLLHQQHDTIDEDEEVYKGEVMDYYLSHPNRPSAATGSSSNYSRSRSHHGGSSARGGEAEALMKPHRFCKVKTGFTWTQYNRTHYDSRTNPPPRTEMWYEFTLFYPALANTKRDMRHIFRIEDTPDGPNDQYCLLVFSVGPPYADVAYRIRKKQWDPRRGGVRISFDQYGRYKLFFRFTNSNYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVS5</accession>
    <name>A0A088RVS5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_292860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700890.1">
        <property type="nucleotide sequence ID" value="XM_010702588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVS5"/>
    <dbReference type="GeneID" id="22577049"/>
    <dbReference type="KEGG" id="lpan:LPMP_292860"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_030014500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_292860"/>
    <dbReference type="eggNOG" id="ENOG502SEHQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271633at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO00233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="122" mass="13569" checksum="B4AB309628674E1D" modified="2014-11-26" version="1">MEHPASSEAERRLSDKNQDALRRLLLIELSVLRRRYAGLFDDHQAKGDTGAFPATAADCDVAPSSAIETSSEDEQTGALCQSDRDAIEALFHSIDDFTREFNEGKGIVEHDDVVTKIMRDFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVS9</accession>
    <name>A0A088RVS9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase family, putative</fullName>
            <ecNumber evidence="2">3.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_300020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701038.1">
        <property type="nucleotide sequence ID" value="XM_010702736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVS9"/>
    <dbReference type="GeneID" id="22577056"/>
    <dbReference type="KEGG" id="lpan:LPMP_300020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300005200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_300020"/>
    <dbReference type="eggNOG" id="KOG1838">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="247542at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034338">
        <property type="term" value="F:short-chain carboxylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF63">
        <property type="entry name" value="ALPHA_BETA HYDROLASE 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="426" mass="46569" checksum="4FEE350FF794953C" modified="2014-11-26" version="1">MSGGPSASGAVAPLLSRVPFSSKVKFLCLHLFCSLVVDLVLRVTRFFSRVWLGRDTTTAVYGSPQAKAFFSLERVDKVSYSDPPYSGHVSTILCALRPHRNIAYERMTHPGADGNPIYLDWLHTDARSAKGVFLIIPGLASSSNTNYIEHFVWFASVNHFHCGVFNSRGMGNSPIETPRLMSAAWTDDLRTALLDGPFSRAAIEKRCGAGISIIAVGFSLGGVILSKYVGEECLAGREVVVDAAMVVNAPLNCLHSHRVMSRSISKTLYQPRMAGGLVAYARRHSKVLKDLPGLSPDVRAAFTLGRLEEVMAHVKTVHDFDRLITAPTLGFATPEDYYHHVSPVEWLPHFSVPVLCIGAADDPVTGELPMTNLASIMSCNPNVALLVMPYGGHLGYIRSVWDEWAGKETSMEKIIYEVAAAIVPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVW5</accession>
    <name>A0A088RVW5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Axonemal dynein complex assembly protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_291860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIH1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700791.1">
        <property type="nucleotide sequence ID" value="XM_010702489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVW5"/>
    <dbReference type="GeneID" id="22576949"/>
    <dbReference type="KEGG" id="lpan:LPMP_291860"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000008400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_291860"/>
    <dbReference type="eggNOG" id="ENOG502S4EY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25887at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070286">
        <property type="term" value="P:axonemal dynein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026697">
        <property type="entry name" value="DNAAF6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041442">
        <property type="entry name" value="PIH1D1/2/3_CS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21083:SF0">
        <property type="entry name" value="DYNEIN AXONEMAL ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21083">
        <property type="entry name" value="TWISTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18201">
        <property type="entry name" value="PIH1_CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIH1D1/2/3 CS-like" evidence="3">
        <location>
            <begin position="165"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO00134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="275" mass="29151" checksum="543582DE0391CED6" modified="2014-11-26" version="1">MTINASDLENLASMLDSNRTFKRPEGQATGFSLEGQASSAAFSSAVVVSAGDPGATSLQPQGNPACIALPPTVVDHQLRLPQPSHGKEAERKRQLAQPARPSGDEIWTQAELMALFMRQRKDGPASVAAAARVAAQQASLQAADGQSRAATLWRPGPSDAATFEEPAHTVLYQQNVSAEDIYLGVDFTRDASSAASDGVTVRVELPRVMSVSEIAMEVDAYELRVSVAGVYYLAAPLPRQVHKTAADAVWDAQKKLLTVRLKADNSGGSDVKIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RW39</accession>
    <name>A0A088RW39_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_271020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700191.1">
        <property type="nucleotide sequence ID" value="XM_010701889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RW39"/>
    <dbReference type="GeneID" id="22576280"/>
    <dbReference type="KEGG" id="lpan:LPMP_271020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270017400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_271020"/>
    <dbReference type="eggNOG" id="ENOG502SFJS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265427at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="420" mass="45498" checksum="607D26D9979B36B8" modified="2014-11-26" version="1">MQTGGAGDLPALPAASGALTDDVQSPRQANAIGTSSEGMTMTSFRAPLPFDRCTISSQQRRGGNLVLFVKSNENESEVASRGTTLGSQQQQYSNGGCADGNIESSSEEGDQGVSKDQERLLSAVVSASAGAIGSVGSITTSAARKPLVIAALVLLYFILLDIVLLSGNERLSRVLRRMRAADDDALILLSTSLVRQMSEAKREVRDAVTERGRNMKVEELAMVRQKVKALERACNRSVSRLHAKLMFPGSIDDLFFLIEEHSTYDERLRDLAAHELLWTTTVMTEQVVQVRGGGAEESRSRAPGTTRPATHLWAEDGDELPSVEKENVDAELNSLRNVRLHRVRGNKAPGMSARRSYAQRRYTGARGTAALRWQSGHTNSFTFAVHGAKKALGGLLTVLRNKCVAFVLICVLLSSVLRMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWL7</accession>
    <name>A0A088RWL7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Autophagy protein 5 (ATG5)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ATG5</name>
        <name evidence="1" type="ORF">LPMP_301030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701136.1">
        <property type="nucleotide sequence ID" value="XM_010702834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWL7"/>
    <dbReference type="GeneID" id="22577157"/>
    <dbReference type="KEGG" id="lpan:LPMP_301030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300015500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_301030"/>
    <dbReference type="eggNOG" id="ENOG502SH1F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272162at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044233">
        <property type="term" value="C:mitochondria-associated endoplasmic reticulum membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007239">
        <property type="entry name" value="Atg5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13040">
        <property type="entry name" value="AUTOPHAGY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13040:SF2">
        <property type="entry name" value="AUTOPHAGY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO00336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="459" mass="50409" checksum="F9124A9D4222026E" modified="2014-11-26" version="1">MLLAIVRDLLQLFRPYAVALHPETTQVWFSVRDTPVSWLYPAGAVKDYVNECIREERAAQLSGLLMSSPSSPSAASLLQSHLCSILSEPLQLIFHIHSLTKGSSLARTVPFYINYDRLEEHIRMEVKQAHKAAYTVLYGNYAIYQREAESALQAAVGLALYRPFDAVAQEQLQQQRYRDLGFRGNSAAGIGSSSYASSGNPSGGHLPPIAFTSPYLLTEYQQLLRGLLTPQPHVAYLIRIGFPFAYRGAAGRAEGEYLQYDSHRVSAAPALALSATVTGAAAAPAIEPDQLPLGLLLWRLFRIPVLRWKAQQPQEHSTDSTVAAAAAPTSAVALSEVEHTYQHLLRTLAPYYADPPRCATDRLEKQEPLLTSTPLEPPAWAAWEHTMVQAFMRDYEEHPGKGDVGLAFVEAAAKSDSPNAGRRVRFMVQGLQPPLSTPGSFLEANLSSSDRAIFVTVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXI5</accession>
    <name>A0A088RXI5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cilia- and flagella-associated protein 300</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_311010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CFAP300 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701489.1">
        <property type="nucleotide sequence ID" value="XM_010703187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXI5"/>
    <dbReference type="GeneID" id="22577527"/>
    <dbReference type="KEGG" id="lpan:LPMP_311010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310016900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_311010"/>
    <dbReference type="eggNOG" id="ENOG502R254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10259249at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029416">
        <property type="entry name" value="CFAP300"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31078">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31078:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14926">
        <property type="entry name" value="CFAP300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO00689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="381" mass="41907" checksum="60D72E9A9AC84201" modified="2014-11-26" version="1">MFLFEAAAPSLPPTHGSAFAFCIDREPYKSLFTKWGLLHPVEWNLHTYRYSCISEATSSTEGTLTAHPVTPPSSSRTANATAGPVAAAALRFHHGVAAGFLRCLFASPCVKADLVSDDAHHAQLHVGENKLQFRPLTCRWTTLEPLRQGLVDAKVVRQVLHDTSGAAVRDANQSVYLLPTVKRAEELLPHGEVISDELRALFLRAHSRPAAQVRGECGDLSSEGDWDDADADDDDTWGLMSGAKLPLGQLRGAFSKESREEFLYHTVWRLIAGSGPLNQFEDDAAVYLDAARELYRCLVKSLRVVEVAEQEKMDDEVALEAPANTLARYKAVVDASIYEVTAAPGMTLFPRSDGVHPSNLNYCYVVVNPSEQTATVWYHRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXM3</accession>
    <name>A0A088RXM3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_310670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701456.1">
        <property type="nucleotide sequence ID" value="XM_010703154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXM3"/>
    <dbReference type="GeneID" id="22577493"/>
    <dbReference type="KEGG" id="lpan:LPMP_310670"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310011900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_310670"/>
    <dbReference type="eggNOG" id="KOG1012">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270970at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052981">
        <property type="entry name" value="Ingression_C2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47052">
        <property type="entry name" value="CONSERVED SERINE PROLINE-RICH PROTEIN (AFU_ORTHOLOGUE AFUA_2G01790)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47052:SF3">
        <property type="entry name" value="INGRESSION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="267" mass="30644" checksum="384BB02BC1AC6B12" modified="2014-11-26" version="1">MGRVELTVCAARRLHDCQLIGLPDPFVRLTMGEKRYKTQVVKNDLNPEWNETFRFQIADEMSDQIRLEVWNKGTYNDDLMGYYTLSLGGLTKGVVKDQWHMLEKSKTQAELHVRLLAVDFGSIPKPEEMWMVTTDINRDPIKRAMEDGTWHPGQKTAPPPTGPPQFQQQQPQTQGVQYVSTSPQQVQYVAQPQPVQYVPLPLQYAQPQPLPGYYQPYPPPQQLGYYPPGPLPPQQPAYYQQVPPPSQQGYYAQPPPQGYAPQPYYHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXT8</accession>
    <name>A0A088RXT8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_312220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701609.1">
        <property type="nucleotide sequence ID" value="XM_010703307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXT8"/>
    <dbReference type="GeneID" id="22577648"/>
    <dbReference type="KEGG" id="lpan:LPMP_312220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310029400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_312220"/>
    <dbReference type="eggNOG" id="ENOG502SHT9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266577at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="497"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="831" mass="88617" checksum="8E9BAF69F1C19273" modified="2014-11-26" version="1">MQFSSHSSSTTSLQDPLCGSALPMHSMMGPYTMSDEGATHPPAMMGAAVGSVTAPSAFASSFYGDGSCAHSYQSATSLSEGSGRGTSWPQGTSLAAKLYQCAGSTSAGGFSHIALYDYPTATQRAVYDDSIAAVTFTESHVGPARRTNSTATSGTALSDCHLSRKDNGGFTLASARTFVKSYDSFDDRSKNSLPSLHDSLTVATSAMSCSVRESVHPHYYLDTTFQRSECDHSRVTRSEDAAIVLSAAQRRLSDSTHLTSYGAASCLSVESSFSMTRRPVGSGRSNTSLQPLHTPPHHQLPEFSTSQNGNHLAPCWRGGIEGDSYDIPVNASSASESFENGLGPTGCPPFYGIDTVAGEDNKSGRSCSAVVSRDDMTPTTTAPWRNGIRHLCSVRLRPASERRDTSDTRRPASASSPNSIATSTASRRFSLLPKAMSNAFTESKETTFSRGSVDTSRPFICHPPQSAPRKPRRKDPRKPNHSRSTSIAAPPSEEDVAPSSASSSLPVTPMTSTMVSKEKTTATLFTEAPHATLTMEGVGGGRASVRSQSPEPLRQQWDAANASNAPMSTFTVTPPSRLERHPPRPLLLRRYVERQLKPLSAREVQMATVPFSPHQAVAPSCNTTNDPATQASLKIAVPPLSPQHGQTTVLDTAQVWSPSATASSSTSFSVTPEKFITVTSGATARRMQQRLAGFAAFHLSSGVEGPGVATENPNEKSLRSLGGRSGMELRLLGESSNGIMSRSCPSVDNSADEGTNAFLIQRSSSWSVHSARSTTDTGEVTSAARKKRQAERMLPIAHELEEEYVTMHPQSSKQCLLKMPSLHKETCANEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXV5</accession>
    <name>A0A088RXV5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_291570</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700762.1">
        <property type="nucleotide sequence ID" value="XM_010702460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXV5"/>
    <dbReference type="GeneID" id="22576920"/>
    <dbReference type="KEGG" id="lpan:LPMP_291570"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290019800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_291570"/>
    <dbReference type="eggNOG" id="ENOG502S8E6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF157">
        <property type="entry name" value="NODULIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="501"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="536"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="593"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="324"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO00105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="655" mass="72163" checksum="ECB761299C991423" modified="2014-11-26" version="1">MITEENYCISEITRFLILLGGLCASVCISTMYGFNILSNKMVELFNLSSSDLTTITTVGIVVGFATFPCGVWLDYAGPVPILIFATTLTTLGVLLYALAFNGNIKGSVTTLAVFCAIMNLGCSSFDTGSLMAVLGSFPLTKGPVVAIMKTFTGLGASILALINYSFFRNSDAHYMFFMTGLIVFMGIVAIVFIRFPPYHILDGEKTRVPQQVQARRRLTERAYLTQYPPMTRFYLGFGIIVSLVVYLTAQSFSVAYANPSDSARMGNTVAIIVLVLSLGLMAAPFPFLGGMDKEASKEYPNYSQDAGIGFENECDKRVLKPAADNTTQAENTPANVYESQKPCDERADASRPEACWRAASQVIVVAEKVVVEKKLPRNNYYDQDPKYDTTFWQSLKQPDIWLCCWNALATWGCGMVVAFNSAQIYRALANDVYESKVNTMYSAIISVASALGRLTMGVLEFILSRQPSETRPVITIAYPVSSICMVIGLIFLLALPLESKAIVIGFFFSSFGNGFSWACTALTVHSVFAKDIGKHYNFMYVGAFIAVIALNRFGYGENYDRQAKLNRDADLAAGRTPIYPRCAGKKCVANSMVILLCVNATAIVGSTWLHLRYRRFVLKRRVECTVELENCRLDVQQAENVQPGLNSVNMCSETH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXV9</accession>
    <name>A0A088RXV9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_311660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701556.1">
        <property type="nucleotide sequence ID" value="XM_010703254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXV9"/>
    <dbReference type="GeneID" id="22577592"/>
    <dbReference type="KEGG" id="lpan:LPMP_311660"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310022900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_311660"/>
    <dbReference type="eggNOG" id="ENOG502S9EV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="242701at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="410" mass="43910" checksum="5E9329DD22B6CEB1" modified="2014-11-26" version="1">MRTTPRLSKGTLNPQSNPRFFLPALSLFLHRPSAVCPAVRTAHASTITQRACVSLLLLHRHLSRDNGDHLPPGTPAVAAADGSPTGEEDDEDLKVETYRPQLTPEDAERKAKTDLFVCLLLTLPRDQDWKDMLAAAFRAGTWKPHHLNAVLHGVQLNKYNEPAECAVSCAASLPFSCSFALRHSIVDASKTAPASSTPSTRLQRARDILIFCAEEGGVHAAPSAEGLFVGVSKAPLSSAEEASRPSKAFAPSAAAAHHLLVLLLQAAQRGASATSPLSDPNTTTQPVASFHDVWSFLAWMELHEYHILSNAVLDALEAVVDEGGSQAGAEAAAGLKSAAGLSSAPFASPLKYAVVSRRVHRLDYLRSERALLRESMKSAEQGANGARMSTGAVRGRRWRDAPRTAPVHTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RY09</accession>
    <name>A0A088RY09_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_320050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO00894.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701694.1">
        <property type="nucleotide sequence ID" value="XM_010703392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RY09"/>
    <dbReference type="GeneID" id="22577746"/>
    <dbReference type="KEGG" id="lpan:LPMP_320050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320005400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_320050"/>
    <dbReference type="eggNOG" id="ENOG502SJAC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="260088at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO00894.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="381" mass="41785" checksum="CAE9CAFE68C881CF" modified="2026-01-28" version="2">MAFSTLPYITRDVATEPPTAIVIVPCGDQPPEMSSKDEAMFAVTEDCVEPTKGWINREGKPLLTVCFMHSFGKCVGRTNSNPATCFQIHIKANILNSLRKHYINPTRRFFARTVKALLSPELRQLLCMRANKELKVQYLEYRVTDVFPSTGLLQYEEAYRRWLFSADTNAEHAGAIAVLQCLQFSTTGSCSFSTDCPCIHADLKKAQARDPILARALRDISEVTQGLPTVSTRVPRSLQPSCLQSFSPVDGSYAMLADGAQPRNRMVSDSLRDFNTVPAFTLVCGEGESGGCHIQLQMHPHESNASSVRGHASGGHHLSRVSLFTRDEPASETISSKVMPNRAKHHNISSDGKNSSDLVRSSSEEVSGTNHHTGSSGSGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RY18</accession>
    <name>A0A088RY18_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Endoplasmic reticulum transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_312560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701641.1">
        <property type="nucleotide sequence ID" value="XM_010703339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RY18"/>
    <dbReference type="GeneID" id="22577682"/>
    <dbReference type="KEGG" id="lpan:LPMP_312560"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310033300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_312560"/>
    <dbReference type="eggNOG" id="ENOG502SAJV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="247630at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="16652" checksum="3BF0D9312521D98C" modified="2014-11-26" version="1">MASFLSLEVNLVMVPVLVLFLLYCVPIRVISTTAERITRLVEGHSFNGFTIMSAMAIISSFSFLFHFLEWHSKYNAKQRFTDISLQLQHDNKRLRVERNMYIQLITCVLCLAVKKCAVLQARQESRQAERTADSRSTAATAHPKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RY41</accession>
    <name>A0A088RY41_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">26S proteasome regulatory subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_320420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO00929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701729.1">
        <property type="nucleotide sequence ID" value="XM_010703427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RY41"/>
    <dbReference type="GeneID" id="22577783"/>
    <dbReference type="KEGG" id="lpan:LPMP_320420"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320009000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_320420"/>
    <dbReference type="eggNOG" id="KOG1556">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10256771at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000077">
        <property type="entry name" value="Proteasome regulatory non-ATPase subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF7">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="2">
        <location>
            <begin position="44"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="359" mass="40348" checksum="0F3E78B053B95B36" modified="2014-11-26" version="1">MSNDQKPSKPDALVVNNDVASDDGSEGKEDVAAPPAFVPTASRVEVHPLVLLSLVDHYARMNTSALQKKRVAGLLLGRYTRDHTGLQILDINNSFAVPFDEDPQDADVWFFDTNYAQEMFVMHKRVLPKVRVVGWYSSGPTIQPNDMLLHLLVADRFCLNPVYCVVNTDPNNKGVPVRAYTTVQGREGTRSLEFRNIPTHLGAEEAEEIGIEHLLRDLTDSTITTLSTQVQERELSLIHLCKVLQQIEEYLKDVGNAVMPISEDVLGVLQELISLQPEIYARRASTEMIRHTNDEAIATFLAAIARCIGALHGVIMNRRKLARELQEIKDRRARATETRLENEKMKIEEATKEKDNNQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYQ9</accession>
    <name>A0A088RYQ9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endosomal trafficking protein RME-8, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_302170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701240.1">
        <property type="nucleotide sequence ID" value="XM_010702938.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22577270"/>
    <dbReference type="KEGG" id="lpan:LPMP_302170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300026000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_302170"/>
    <dbReference type="eggNOG" id="KOG1789">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="69656at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000641">
        <property type="term" value="P:regulation of early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044978">
        <property type="entry name" value="GRV2/DNAJC13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045802">
        <property type="entry name" value="GRV2/DNAJC13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025640">
        <property type="entry name" value="GYF_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36983">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36983:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14237">
        <property type="entry name" value="GYF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19432">
        <property type="entry name" value="RME-8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="1377"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2421"/>
            <end position="2444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2444" mass="272310" checksum="0C2CE1EA7391075C" modified="2014-11-26" version="1">MSSSLAAGSVSLDHHSFTSCYTVTKHSWRGKYTRIFCVGPQGIATCDVRSLTKLTNYWPYTSSVRNIVADGVNSSLFLLIIQSNGNRAEELRFSCGSDAERVQLLTDVNRHRLLFDCNYRASLAVQVYGAMKYTINETLRPCTLRVTAIGVEQLCRIGDSTSSNAPAEGVAPASSPVPASATATSRGTGALPEYEKVGEYLFCSIRGITTIVDRPGSIVIAYGTEMKMHLYDVANVKPLIEAIYRNTTEYVGLPRYREMNVLQQTVFDSERLGIRRDALEAVEEFSVLKHSPKLHDATVRRLLSTTPIAIVERDPVTYNPISVHFLHSVFALVRCEDDDQRFLILFKDSLVKKSYQSPVRDTILAHVLTACYSAGDGNVCVTSRPLLRRNRLSSLNTPVTEEVESLLLKGLVDGRLAGAPGAGDTSDLTGGGVGAGLMASLELFNTNVPRTGLTWSENRDGLFSENREKLIFNAVEAVLGHFSWVKPSSSKTKQDNNGGGGGVTLDAVHQHFIVEQFQALGRLSVSRVGYSSIALVPSLFKSVGVYSVQALRLNNLAISFAVIEFLNTLMTPFHNHYEIEHESINKNRLLSAEGFIRSLMEVLRDHIPNESASLLVLELLFFFEFALCPPYSTTTDPAHFKRLLGDLVDILGRHLFDLLSHTCDIIRYTAGQLIRVVMEEGDKTQFTRMQQLALSEGGILTQFNTAAFSSNRKPRSLARRLIAYWAHSNVPTQDILRRMVPLTLLSFLQSEEQAPPSEWELEEQKKVTQMTALFRESKTGWFKKSFNPCDVTLEANRSAANGPTGAASSSAADLPVADGGRVRYRVRDVKVAPTINWNMFFYQLKQDHLRPDLIWNHTTRAELKAAVQAELDAFRQHSDMRREKLIAWNYTEFEVVYHSLDSELKIGQHYPRLLFEDAHPVIARPREFFNDMYHRFLLVQDPKSKLECLHGLALLYTHYAEDIGEFHDVPFLLQMLQNTTDPMMRDRLLLLLAHLLKARHNIKLFLDHDGLAPLMELVTVAHLHIDRPQLKSVSNAIEYAGNLKEMQGQEKEWHYTRNGVKAGPVSFSELKELYKKGEVTATSKVWAQGMSGWREFSTVAQLRWGVLSADLPAILTLTEVTCTVLDVFLLLCRHYPSVNDEGAIMQPQPKVKRLLSSPSILPHLVQLLLTFDSGVCSRVHTLLLSLMEANPLVGHFFLTGVFFFSCLYTASDVLPMCRLLAATHHRQSFQYAAAKNDLVRDSILAPLLPPAMVCYLTHHGPDAFADVLLGEYDNPEAIWSPAMRQYLAAKAAAHVADFTPRLLGNNTAIYQYCPIVGVQYESLQRELFCSQYYLRHFCDELRFPNWPVRDAVRFLTDVLQQWKAELNKQPSLLTREACYKLLELQPHPSKQEMRKAYYQLAARYHPDKNPNGREVFEQIQRAYEFLATDSAESSEPSPYNISLLLKAQSILFKRCGATLRQYKYAGYSLLLHLIEKEFRAPDALNKDVVLLDPATELCYFTIRNAPLNADELQEENGIHLLADIATYCFDLITPNSHDTDVQVRIAKHCMLTFSICARFPDCRLKMLREKQIPYLTAKGIAYYQTPELSRACTRACASESRSQKMQSELISYGSIWHLLQPLFFYDASLDKAGVGLDEEHHKQLFANRTAIFALHAIYALSGISRRRSMVSDDPAGSDAQDRVESVARDEDAAEVIADGNVQATRHVGVYELLQRLLTPFILYKMELQQDNEAEVLMLLNSNSDTPYFLWNNSCRAELEELLQRNSKTFREAAFGATDLPSLSTSLAGFTYSLHASEVVVGGVFLRLFIAQPNYPIQSPVDFFTALLVFLLDRVANVTNKEGGAGSAAGAPTSLSNERSLKEAPLLAARSLRLLSGAYTEALSATVSKQMRSLVTLLTPSLAVAKADIPVARNEESMRSSLFLDIVQALAKFLSSDACLQALSAVETAMTAVVLLLEQILGHYDEAHSTSAFSSDEPDAVLALIWLMLAHRTLVQQSLDRGLYIFLLSLYATSPREKVREECCRCLAKGYDDRLVGPQLFLRSSRYLPAAFLEMMKDNVKQACRMLDSRQENPELLWTKTQREELVQQLQVSRRQIVAALSTDALACWKPCDIAGDSVGAIKSSVESNSGDADTTGSHLRRLQVGGVYVELYVQQPGWAVRHPKEFLQALLDRFVEEASKAAAPTSTLSSGTAAVPDINVLELLTKAGKILLNNSPGLRDYMASLGYGSKVDRQLSPVTADHVTNEAVVCLSLQWLREMSRSTACVESMSSSSDLLPSLMNVIQQYPALTMEALQTLEGFLSNATRRSRVLEYALRDHIPETLLKYLEEGLPDSASAAAGVSAATIRAALVKVIKALLAVPDEARTPDIHALLDKSLVWAKYKNQSHDMFLTQTHFGGYLTASSTTHPGAAAVTLSLTAPTTAEANTRSEPPPLEDHSGAPLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYR6</accession>
    <name>A0A088RYR6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_322430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701929.1">
        <property type="nucleotide sequence ID" value="XM_010703627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYR6"/>
    <dbReference type="GeneID" id="22577984"/>
    <dbReference type="KEGG" id="lpan:LPMP_322430"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320030400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_322430"/>
    <dbReference type="eggNOG" id="ENOG502SHUC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267529at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="235"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="362"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="427"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="29"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="440"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="453" mass="48353" checksum="9ECF6CFFF20DED92" modified="2014-11-26" version="1">MSHQPSSAEELYELVCALQKEQQLTHVDLRTVQRRTEALRQELQRQQELIAEEQARQEELAAKLTQGCVERRLAEAHARGVARASADAAQELCFERRAFVQKCHDYVLSVGKGPTDRGRFDLLLLPSKGTILSTATDGSCSGTFTTAAVEAGREASFLPAAAVHQLLLSLSKKLTRCVEVGATAVLAPLNVPSTVTLTTEERSREKPADRRPSAVQWSTATVVATLMAARITTTNPHRPSSAHVMEGSVGSAADGQRSPHEKKRIGFAPASCFERVTTVPAANVNRGTSQAHPAEGSPSTANNAAVMLPPANIATDCSNRPAHACLRSGSRPRTQRPSGHFTVRLASRSATLVAEAAALGAKRQRSSEAAKITQSSPPKAARADGDKGASTCTVPQCANVTAALAPTYTNDRDHLVSSVDLPLLRSAETQGNGNGRSSRRSVWTWTRGTTYGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYX6</accession>
    <name>A0A088RYX6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_330600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702153.1">
        <property type="nucleotide sequence ID" value="XM_010703851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYX6"/>
    <dbReference type="GeneID" id="22578213"/>
    <dbReference type="KEGG" id="lpan:LPMP_330600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330010700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_330600"/>
    <dbReference type="eggNOG" id="ENOG502RYW8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="339900at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036265">
        <property type="term" value="P:RNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028884">
        <property type="entry name" value="Trm82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16288:SF0">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT WDR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16288">
        <property type="entry name" value="WD40 REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="90"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="529"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="529"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="541"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="566"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO01353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="575" mass="62598" checksum="2271480219A2683F" modified="2014-11-26" version="1">MPRNLNDASSLSVATLPRKAVAIGFGTKLIIGRYPLGDDTTPSPHNSVMVDDGQIVRAVAFLQIPDGPLCVLSAGDKKFINVYNVSSRKQNNPNALQNSSDEDDDEGRTDTADLMGSEARRKSTTNAGPASFKKSQLAKAEYWKPSYQYGPHTKRITSLATCSEGTIVYADKFGEVYRIRLSWSPSHTIEVDGDATKPAVFLLQHFSTISTLYLTAPVPRIEPVAASEERSGVACRRLFTCDKDCHVRVSRYPETYVVDQFLWTHSAVQSPVTCVAEIACAEDAALYGSSYHYGASCVKRPNKSLSAPYSYYATGTHAGDVCFWAAKNNVPVESNSETFHLISTFHPRAPGGQPENFGPVVGMTVLTSSIDSFGNPRHPRDCPRGVLIAYERSSEIFFVPIFDNVGTYAMHPAMVSATRTPLDARPVAMVSSNETTGFVLKRNGRVSFLHLCVVASPTTELPKTCSFNANIPVEVQELPIRVPYLEERIKAIMCGPAAEEGTAPAAAGDDKLSELEALDLCASWRYEAVDPRTRRQRNDEVDGDDDSSEGGGDEGGEAFSSPRKGNDKKKARVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZA5</accession>
    <name>A0A088RZA5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine peptidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_330410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702134.1">
        <property type="nucleotide sequence ID" value="XM_010703832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZA5"/>
    <dbReference type="GeneID" id="22578194"/>
    <dbReference type="KEGG" id="lpan:LPMP_330410"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330008600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_330410"/>
    <dbReference type="eggNOG" id="KOG1552">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="446723at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="68"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="403" mass="44792" checksum="7B539F43D69895EE" modified="2014-11-26" version="1">MQSFVNSIVFVPPQNPNSLQRVQLLQHRRHMSFTSKNSGERISYYHFDTNGNLVTKDSLERVVRTSMVVLFHHGNSEDLGSTFSYAQSIACAFGAAVVIYDYCGYGFSGFPDASTPAEVTEKSVYSDADHMYDHLLSLGYPAYRIVIVGRSVGGGPACYLAEKYHKEVGGLVLISTFTSCLRVVSSCCLPYLCCCLDLFPNYRRIDHIMECPVLVMHGTHDEVVPYRCSRELLEDIVKHRTRALQRLLKKREGARANQAKGSTTLRVASAAPINTALGFTTVGVSDELVTASLPPVDEVSVFDLYRRAYDSLPEAVRRMAKESLDVTAADVSIGVFHRWFPGCGHNNIKAREERAFSEVFKYFLCFTAAFSLEREALLSSKSAASVARVSGDFALRAHSEDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0G3</accession>
    <name>A0A088S0G3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_340370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702466.1">
        <property type="nucleotide sequence ID" value="XM_010704164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0G3"/>
    <dbReference type="GeneID" id="22578541"/>
    <dbReference type="KEGG" id="lpan:LPMP_340370"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340008900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_340370"/>
    <dbReference type="eggNOG" id="ENOG502S14N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="249710at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="547" mass="57299" checksum="800054C88D9ED58B" modified="2014-11-26" version="1">MSYGFSTINGVLPRGTKRAYVPRAARPHLAWSSAQPSRAIGSQCRLKGDGTAARERTDCVEGTEAEGDNAALTPFSPTELGVARLLTTDAVSGTRLTLYTNPSVPQLALHSATIPSQRRVVALWTPPTSTGSDNGGGEACVVTPLFVSDDTGSVFAYQWSGSESFSEPAEKRRRIDGKTECLASEAKDGIWTPVAPARSTVSSDVAQMQSSTSTMSSLFSVTRGAPGWAGLTALHASLSCSEALQLVSVREFYHDVRLIDPTRQTVVRTYGTTHAPTGVLCPSMQAAPHCTLIVEGCLATLYDVRCPSAVVSLGEVYEAQAEWRAAKDAAAVENGKQDGCGVEGGVQANGKGLPGVNAAVAPAPAPPLIPGRLTSTVGHVRDVCGTANPFEVACAVDRALCVYDLRKFNRLFTSSSVLKYVVGSVASVAGGRGIVCAGIDAEVRLIPLHEKSDAMTTDTLSLAARVVMQAQQKKKQRCDTCKSPGQLRKTDDEANTKPVGPGGTFRTRLSTSVSCTTVWQGGWVTTCNGGGAAAVGVSVDSELFLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0L1</accession>
    <name>A0A088S0L1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_321900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701875.1">
        <property type="nucleotide sequence ID" value="XM_010703573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0L1"/>
    <dbReference type="GeneID" id="22577931"/>
    <dbReference type="KEGG" id="lpan:LPMP_321900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320024600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_321900"/>
    <dbReference type="eggNOG" id="ENOG502SDXR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="242742at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="155" mass="17068" checksum="FAA3067987AF3A7D" modified="2014-11-26" version="1">MSTARRSRGCNGKPALGETYSRADEALWDDAYLLKLFNEQLDNADAVKDTREDGQDHDHSVLSTGTESSEEEEEEGRVSTSATSSGTAATERDVRAQRGSTSAKSKMISHHFSTLNGLPEDIQALVHSFYNAGFEAGRFIGRSDALKKCSRKRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1K5</accession>
    <name>A0A088S1K5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_351210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703058.1">
        <property type="nucleotide sequence ID" value="XM_010704756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1K5"/>
    <dbReference type="GeneID" id="22579150"/>
    <dbReference type="KEGG" id="lpan:LPMP_351210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350017700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_351210"/>
    <dbReference type="eggNOG" id="ENOG502S6Q3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="263737at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO02258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="335" mass="35920" checksum="192482F402616376" modified="2014-11-26" version="1">MLCGSRVMLARSAVAFFNMKHFQAKKKYNLTPQNTYETLSTVLSPRDRLLRQSVSGSGGSRVLVLDTQQRVKGVYLPVFCMPHPSTITKGTNSLGVEVAEYTRFIEATSAACKAGGGVTESTLPTVLVVMSHPQGLAYGTFRADGTPGVPMKNLALGSILADPKTQQEAVTIASATLKSSGLGTVMPLLQVPYGHAEAVRDIYKELNECKHAAELAACSTFVWVQRDSESSTSFKVARSSEEYWARARNEGESGAAPVPGPISFLDRRWVLLTDVVLRPDHGLGLYGRDLATGHRIVDPIGLQSALCRGSLLLDHIPRTVIDTTRDTAAGTGASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1P4</accession>
    <name>A0A088S1P4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PhosphatidylinositolN-acetylglucosaminyltransfe ra sesubunit c, putative</fullName>
            <ecNumber evidence="10">2.4.1.198</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_351760</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGC family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.198" evidence="10"/>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703113.1">
        <property type="nucleotide sequence ID" value="XM_010704811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1P4"/>
    <dbReference type="GeneID" id="22579205"/>
    <dbReference type="KEGG" id="lpan:LPMP_351760"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350023600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_351760"/>
    <dbReference type="eggNOG" id="KOG3059">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="196709at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017176">
        <property type="term" value="F:phosphatidylinositol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009450">
        <property type="entry name" value="Plno_GlcNAc_GPI2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06432">
        <property type="entry name" value="GPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016104">
        <property type="entry name" value="GPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIO02313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="386" mass="43346" checksum="7C9B9BEA16585260" modified="2014-11-26" version="1">MSQQFTSSENLDSSQQQLEADRHVTSTEESSRTESRDYDHRSSEAERYDSHLAQHQRESSKQITSCNPQWRKVLYERQPFEDNYVDPQQFLEELSHNKDIKSYKYAAVVINTLAITQEISIVVLFCHAFMGVFTQSIGKYSLVVIDVLSVLAALVCYVFYQCHQGNCRATAERRASRSTRCSSPSRPPSQWVFHAWNFGRQVVSLVTMLILLSPILSTLTVTYSDDTIVTLSILTMSLHLLLTDYSYLNACTQRFDPNLSVNMAIYCVTLMASRISCPLASGALICFGIMCFSLSPIVRHLIRHYSFTAHVATTFGLVGLAIGCLTQIPILAILYTVTVLMISFGIPWLFVRMHSSVKTQINGPWDEAKPTNSAAAAEWANSGFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S299</accession>
    <name>A0A088S299_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Phosphomannomutase</fullName>
            <ecNumber evidence="5 13">5.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">PMM</name>
        <name evidence="14" type="ORF">LPMP_352040</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>alpha-D-mannose 1-phosphate = D-mannose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11140"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="EC" id="5.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the eukaryotic PMM family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.8" evidence="5 13"/>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703141.1">
        <property type="nucleotide sequence ID" value="XM_010704839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S299"/>
    <dbReference type="GeneID" id="22579233"/>
    <dbReference type="KEGG" id="lpan:LPMP_352040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350026500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_352040"/>
    <dbReference type="eggNOG" id="KOG3189">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264771at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004615">
        <property type="term" value="F:phosphomannomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02585">
        <property type="entry name" value="HAD_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1240.20:FF:000001">
        <property type="entry name" value="Phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005002">
        <property type="entry name" value="PMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043169">
        <property type="entry name" value="PMM_cap"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466:SF0">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03332">
        <property type="entry name" value="PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00445">
        <property type="entry name" value="alpha-phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01143">
        <property type="entry name" value="C2.B.3:_Phosphomannomutase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01140">
        <property type="entry name" value="C2.B:_Phosphomannomutase_and_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIO02341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="247" mass="27990" checksum="8CFCA7753A38873A" modified="2014-11-26" version="1">MAAKTILLFDVDGTLTPPRNPETNDMKEALSKARAAGFKLGVVGGSDFVKQKEQLGESILEDFDYVFSENGLLAFKNGKEFHRNSLLKALGNDKVMAFVKKCLHLIADLSIPVQRGTFVEFRNGMLNVSPIGRNCSQQERDEFEQYDKVHHVRELMIADLKKAFPEYQLTYSIGGQISFDVFPKGWDKTYCLQFVEEEFKNIHFFGDKTSEGGNDYEIFCDSRTVGHSVKTYHDTIAILEALIKESH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2K1</accession>
    <name>A0A088S2K1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spermidine synthase, putative</fullName>
            <ecNumber evidence="2">2.5.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_354920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.16" evidence="2"/>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703423.1">
        <property type="nucleotide sequence ID" value="XM_010705121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2K1"/>
    <dbReference type="GeneID" id="22579520"/>
    <dbReference type="KEGG" id="lpan:LPMP_354920"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350057700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_354920"/>
    <dbReference type="eggNOG" id="ENOG502S2NW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271127at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004766">
        <property type="term" value="F:spermidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="511" mass="56390" checksum="A5554E53C5C2810B" modified="2014-11-26" version="1">MPPRTQKRQRTASELKFHHTKRRRVSEALVERGIEREFDRTLPFWRCFIDLRLATGRVPEIVKRNTQVLCRIPCKVFKRVDVVWARTTVQLRPVHVLTWQERKNRTRPPRLSAKVPAEAAAAWAVASAKAGNEMPPPGTDTDSALHMYTIDTVHFVHEDAYKKGTGSDHSFHVQSVVFRDAPHILQCVGGSMVSFSFIIYTSLRLAHACAVRKCTAQQLGRELEEVMAACNESSTSMSTTSTSKGASGDSAAGGTSDTRQDAEGSWHTHSTTQTGQDSLAHKDHGKRSTTATALSGLRAWCPPPTTRSLILGMGGNSMAPALRLVLGVEAPIEVVEVEPAVVASCMQMGTLHDADAKTKVYLQDAGKCLATLPQNAYDFIYMDIFEPVQATMRNLHPWVLAARELLKPGGLLVMNDHHLPSAEGVAPYAKVFGEGNVQAVNVRGWSESIVVCVTPGDAATDKYSLEICKTHADISFNIYETLVPGWLPHFSWLVKAKTYRHDGVRCRLWTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2Z0</accession>
    <name>A0A088S2Z0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vacuolar sorting protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_354780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703409.1">
        <property type="nucleotide sequence ID" value="XM_010705107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2Z0"/>
    <dbReference type="GeneID" id="22579506"/>
    <dbReference type="KEGG" id="lpan:LPMP_354780"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350056000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_354780"/>
    <dbReference type="eggNOG" id="KOG2319">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="300289at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.80:FF:000017">
        <property type="entry name" value="Vacuolar sorting protein 9 (VPS9) domain containing protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF25">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="2">
        <location>
            <begin position="528"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="755"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO02609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="931" mass="101433" checksum="655DE1FAB77E2DA7" modified="2014-11-26" version="1">MTSVEARDAVKQYELRHNVLLQSILPGGLLSSLELKERCDALLVPRQISLEVMHIAPYFLATARRPSFVSSTKAAPTLAALFGEKEDLPERCSSSNQETEATGDAATTAVVTFPPEKTDAFRAALARFLEYHLLHFDSLGNSEFTNLSGQRGTFTEDLNHVQRFGHLGQVAVLAYADALQPKSSAIDTDGHTPAGGDCSRDPSSLQIFIIDKPLMDTGEVHLVTDALHKLTKPATPQIEVNKNASPHKTSLVDIPFIMGDRNASDPTARLKPLTQLFNLSAPSPNRVAAANATGPGGTDSGDESAAETVVIEDRGDEPPKSPVLEDYIERYTHISKRQRPQRESNCAFSAKAHHSGDVSFPDEVIDVPTPPTLLTSVCAHQGVAAPTAGSSQRASSATDPKDTATATIIHANVLRHEYSRECIKDYRRVVAADNEIFYGEFERLMLLRCAGPLAKVINEYVSKNENSHQPILNTNMYNKFVERCHTVLYQTHRLSMDKERLVIMQEGIERYVTSRLYHQIFNVCEEEKSQSKLLQEKLIRLEDMTSAHLHAFPEVEQHHVWGQAMFELDGMDFFKSPREKLRCGMRSCELLSLAVGDIIRQRRSPKQPGKAAEAPALGNGGSVPLAFGADEFLPCFLLLVLRARPLRFVQNVLYIEKFRYPALMSAEESYCFATLQSSLLFWQNCRDDGQMDSACATDVSLGRVEAPPHNGSLGNAGAPCAVSSSLSGVMQPPQPPPLMTEHDLLPSVRQASSTARQQAAVDCNSRLTNGPDAPLSEGKTHAEETPTVLGVLFGWANRSLAPLASEIGLGARTSDKVGNVSTLGRETVGAESSVIPASGAIGYQSPLRGTVVSSTSAAPQAEVVRDGSFSEGVSHAALAPSLPPPLPYSNVSSRARVRELLVAQNKLFDQLTLPELQMIVEEARQLLLEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3B2</accession>
    <name>A0A088S3B2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF3456 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_355790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703509.1">
        <property type="nucleotide sequence ID" value="XM_010705207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3B2"/>
    <dbReference type="GeneID" id="22579607"/>
    <dbReference type="KEGG" id="lpan:LPMP_355790"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350066400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_355790"/>
    <dbReference type="eggNOG" id="ENOG502S2ZI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271487at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36058">
        <property type="entry name" value="NUCLEOPHOSMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36058:SF1">
        <property type="entry name" value="NUCLEOPHOSMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839189" description="DUF3456 domain-containing protein" evidence="2">
        <location>
            <begin position="37"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO02709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="37199" checksum="6B70E873E4DE181F" modified="2014-11-26" version="1">MPCNPRSYVSSTQPLVTAALLLLVCVLAVATGCASARKELPLNIPYPPIVQNALRCNVCSFIVDNALIYVQGMRDEMSQHRLQLREDDVLDELEKLCVPFKDPGQWIRQVSLRVDETKACRNAETSVIEAPRQVMKVALVEYYSKCGRTCDTVALLCEEWMDSGYMDDFPSYLVREANSGYNISSEEHRFAVFSQFCAPTPHCENIGSALRELSEELTKNSELREAIDADRPQEIKSEEREMEMMLHRLTREHGQSADVFSRDEVHRMKEAFLKGNREELKAVDPAAFDLTDSEFSMLQNYIRGEAPEEKEWEQQRGSSNPSDAEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3J5</accession>
    <name>A0A088S3J5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sulfurtransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_091470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN96061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704383.1">
        <property type="nucleotide sequence ID" value="XM_010706081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3J5"/>
    <dbReference type="GeneID" id="22572717"/>
    <dbReference type="KEGG" id="lpan:LPMP_091470"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090020200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_091470"/>
    <dbReference type="eggNOG" id="KOG1530">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="566238at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE RDL2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086:SF10">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE_RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00683">
        <property type="entry name" value="RHODANESE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="19"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="119" mass="12965" checksum="C96A60FECC4EA38A" modified="2014-11-26" version="1">MQRLTYAAVKALVAKKQSGDRHMCILDVRSADEVAGGAIAASVNIPLDQLESALQLTADEFKEKYKAPKPETSDHVVTYCLRGMRAESAAALLRSSGYTNVDVYPGSWTEWSEKEKSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3Q1</accession>
    <name>A0A088S3Q1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prolyl endopeptidase</fullName>
            <ecNumber evidence="6">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_356930</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of Pro-|-Xaa &gt;&gt; Ala-|-Xaa in oligopeptides.</text>
            <dbReference type="EC" id="3.4.21.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peptidase S9A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="6"/>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703621.1">
        <property type="nucleotide sequence ID" value="XM_010705319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3Q1"/>
    <dbReference type="MEROPS" id="S09.033"/>
    <dbReference type="GeneID" id="22579721"/>
    <dbReference type="KEGG" id="lpan:LPMP_356930"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350079100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_356930"/>
    <dbReference type="eggNOG" id="KOG2237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="248387at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070012">
        <property type="term" value="F:oligopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.120:FF:000001">
        <property type="entry name" value="Prolyl endopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000005">
        <property type="entry name" value="Prolyl endopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.120">
        <property type="entry name" value="Prolyl oligopeptidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002471">
        <property type="entry name" value="Pept_S9_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051167">
        <property type="entry name" value="Prolyl_oligopep/macrocyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42881">
        <property type="entry name" value="PROLYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42881:SF2">
        <property type="entry name" value="PROLYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50993">
        <property type="entry name" value="Peptidase/esterase 'gauge' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00708">
        <property type="entry name" value="PRO_ENDOPEP_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S9A N-terminal" evidence="8">
        <location>
            <begin position="6"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="7">
        <location>
            <begin position="477"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIO02821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="697" mass="78313" checksum="5A95393FB80B7004" modified="2014-11-26" version="1">MKSFYPTARRAAVTYQLHGCTIHEPYNYLEEPSNAETKEFVRQQNDAFETYMRSSHETRTKIAERVTAMLNYARTSNPSLHASKYYYHYNTGLQNQSVIMQATSLRDDKPSVFLDPNTLSADGTTALKAHAWSENEEMFAYSLSDKGSDWQYIHVLNAKTRERLPDKLNWSKFSGISWWRNEGFFYQRYPELSEEVDKGAETDLAQNQYVCFHKVGTAQSEDVVILQVPEHPQWILASKVTDDQEYLVISAMDGCEPYNLIWIAKLPASYGDLQRPLAFNKVVNTFVGEYRYLGNEGKTFYMTSTKEAPRKKIISLEFDTAEEVDLVPQQQSVLSMAALVKDTLLMVYLEDVKDVLYYRKLHEVAELTKIDLPVGTVTSLFASYKKDFVSFKISSFMLPGRSYVMDINDPQGSLTVYRDDTVDDLNVDDYATEQRFYESVDGTKIPMFIVYRKGSLSASSPVMLYGYGGFGISLTPSFKASYIVFLQNLGGVLAIPNIRGGGEYGQSWHDSGRLTKKQNCFTDFISAAKHLHDNGIGSPATTAIMGASNGGLLVAACANQAPEAFSCVVCQVGVLDMLKFHKFTIGHAWIPEYGNPDKVEDFKVLEKFSPIHNVRTGVKYPAILVVTSDHDDRVVPLHSLKYVATLQHTNPELGGPFLARVEVAAGHGFGKPISKTIEETSDMYAFMAKSIGATWHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S420</accession>
    <name>A0A088S420_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_352080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703145.1">
        <property type="nucleotide sequence ID" value="XM_010704843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S420"/>
    <dbReference type="GeneID" id="22579237"/>
    <dbReference type="KEGG" id="lpan:LPMP_352080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350026900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_352080"/>
    <dbReference type="eggNOG" id="ENOG502RZAT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273244at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF9">
        <property type="entry name" value="IMPORTIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1149"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1181"/>
            <end position="1200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1274" mass="136823" checksum="B9E135E172C4B04E" modified="2014-11-26" version="1">MSLDFLVSQILTPDNVQRAVAEAELERRSREVPGFCFSLARYCRTLMSSQSSHAVGLVALSVLKRSVMASNSAEELEQVVSSLLSDLSDIAALPGGATAVMRQWSSAVCKTVRRLVVLWASPTATPAAGEATTGAIIAQLLGVFGQYRNADASGLLSVFSHVWLLRTMFEEPMPEVMHAWCAELLLSCAPPLFEILCTSAAAALSMSLPDSSALAADSPEVYARCSLLTLIAQTLTALYEWQFAFNGRKRFPAELKHHFLSAYPLLQPFMCTPCAHWLSVCIGATSSSTDTLPSAEALAANLATASLAVLEYVSSVLQLSGWYKRCISAQLLQVLLQSLEADAACYRAALCGDGGEEAYSVAASAEWTGWPHAGSGGGEPNEDTLSYTWAAVVRRHATQSWSLFRDAALLPFLKVGLVDVVGHQCGLQYYKLLLTYAVLSPADVEAWLHDPNSFLREEEEREDGVRWTTRDTVAQLYTDSIAALGPLFLHASLEDLHECLLAAITDNDDRECSSEQPSLAYDGTVILTPSQQQREAALFFMEVVLKRRAKELRECGAVDFTPLATHLWSNDVASATVHPGLIARSLMLLTAIVRLAHATLAATAPTASADAAAATNTATAAESFMATVVADSTHALSLFTGTSKEAVAASSSSCTPLVAVLLCRFLHGTLPYWSDVLLAQHFVAWQVSLLALLSPKAGLTDDALYNTVEQLADLLKVACAAQKKGRQSHHGSASTAAAAPLMSSSLPQTVMNCWRRNVSDPNLADVVLRLLRHVVRDDQSGASLLLRELPWVNNVLSGYAESTAELCAVPYFLHLLKYFFEYSSDEVANGAATMILDSLCQLLLSAEESAILGALSGCLAALLRRCLAVQSVQVRVVVATMEAAMTSGAAVAEGALPGVVSTAALVVDAPRAAYPFSTVIVAFVLRTLDDRRNEASLMDMGDALVAIMQRSPSFSEAELIHVIHATVHRLSMVRTDTVAQQLLAPLATLMALHPAALLRTLAQGGSLVETMSRWLPQVEHFSNLRTTFVSCEGLLKMLSCLSQSSPPMLASEEAQQLAQQPVTCRWRLPEELAASEKGLRTAQRKGVKKDSVAATRRAILSSLTSGASVETSLPLYAGVFVGVGRGLLTLLAAPASLLCRACQAAGDTTTPRIGIDTSTSPSDEDDDNSNELFREDIADGDHEEEDMWEEEVDSSDDEAQGDARQSEAPVINGYSPHERSDRQRLLRPIGALMLPWLQTHGSEVASFFTVQEVQTLMSFLTSCAEIGACDSSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S4E5</accession>
    <name>A0A088S4E5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_120180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009381">
        <property type="protein sequence ID" value="AIN96346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696999.1">
        <property type="nucleotide sequence ID" value="XM_010698697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S4E5"/>
    <dbReference type="GeneID" id="22573024"/>
    <dbReference type="KEGG" id="lpan:LPMP_120180"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_120006600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_120180"/>
    <dbReference type="eggNOG" id="ENOG502SJBQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="260710at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN96346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="427" mass="46632" checksum="90361E01E9158207" modified="2014-11-26" version="1">MPSRAAAARTIQAWLRRRRELQYAHRLLLCLHVMKVLRAPDQLHCSDSVNPLVFLALGEVTSSSSCSVEHRVPVEESLFTRLYEVVVEYESALRLENYTRQLLFEEYCATSDAARLASQAMRHMLQQRHPALRPLSLSVEVMQQAVAGFTSAPQLTADSTMTAAEKLQAYLSPAHFAWWRTPQVPSIVSASVSTAAPLHTNGMVNNVRPQPPLPLRIEHSNTHAAESPQGERWGPVYMEVDDQEEETSNYEVAVNAAYTREREAAESAALLAAQQATMARCPTGFTAHDGRQPAGVSLYNASSTFLPEEDDISLVVQPVLGCVAQRCCHSVHEYLDPAPSLMPSPVMLNESQAGRETTTQVCAVCELDGVVASPYSNCGKAAERWEEDMLHPCDTCGALVHLCCAYSGATADTHFCCGHCCSGGGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S4S5</accession>
    <name>A0A088S4S5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_355040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703435.1">
        <property type="nucleotide sequence ID" value="XM_010705133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S4S5"/>
    <dbReference type="GeneID" id="22579532"/>
    <dbReference type="KEGG" id="lpan:LPMP_355040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350058900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_355040"/>
    <dbReference type="eggNOG" id="KOG0516">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21595at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008093">
        <property type="term" value="F:cytoskeletal anchor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051764">
        <property type="term" value="P:actin crosslink formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000118">
        <property type="entry name" value="Calponin homology (CH) domain containing protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46756:SF18">
        <property type="entry name" value="GAS2-LIKE PROTEIN PICKLED EGGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46756">
        <property type="entry name" value="TRANSGELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="2">
        <location>
            <begin position="194"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="460"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO02635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="720" mass="79048" checksum="D0B949B15EAF4F34" modified="2014-11-26" version="1">MSTQFSEQDKEDLTEIFRIYDPSKVDKVDDTLALSEKAGQTPAELFDDLYKLFGIQKLPQRDTVAKRLLAAVSNATADDIESAIRQSEMKGFTERDALRLLERKYDVQHVNTRVLSASRNSQSSAQHSTLEDESEVARASRSLRHINVNEFSMASRTRLEASGDVAEVAPEPSLVSDQPLSKLSAAPRREDLDEILAEEMREWLAKVVGEKYNADVLTMPNFIDALRSGILLHVLLQKMENPPIADEDLKLPKRTTGFFIRDNVATFLTEAKKRYELVDAQLFTASDLVDGKNDRQVVTCLMSMARIAYGAGTIKIAPNIIVYEHEIEQQQSRLTRIDLDRIVQEAEADEETPAIATRPNDTAECPSSNVAPASAITSLTMPSHDVSEHVAPSPIQASSGESESALMQDGLASTEVAVDGFMRCSTPQRTAVTANDEPRESSGEGTAAAASPSTPPLRKSPLSESLPPASERTLSTPIIEHAAESRAMSATTDVGEQSLSRNGPVGQPSRAIAQLTPTRSGEALAAAAQCTAAAPPAETTAEETEAQGTDVSGVAPLEKIGAGEEVIDGSDRVMYLRDGGGRVFYLRDGVLRPAKSSAMEEKVVAERRTKAGPRVVWKEPISPLATTRPPRYHSRHWDGIDVALGRHLNEHYEKHHRSPWRFRSIASTSGEYVLYNRLNGSRRVVFLRIIQRKLFLRNTGKHQPWIEIGDALGELEKLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S510</accession>
    <name>A0A088S510_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">A44l protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_356010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703530.1">
        <property type="nucleotide sequence ID" value="XM_010705228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S510"/>
    <dbReference type="GeneID" id="22579629"/>
    <dbReference type="KEGG" id="lpan:LPMP_356010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350068500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_356010"/>
    <dbReference type="eggNOG" id="KOG0743">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="311"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="556"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO02730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="722" mass="81349" checksum="DD9B7F6CEA31B52E" modified="2014-11-26" version="1">MLPQRVADIPSSTLTSSLESSRLFTLLRAFEARVVTLEAVFYRLLTNYTPFPFEVTVIVVVFGYIAIRQIALWYISNVPTEHAYVYWKLHDLIDSAYYSPFLPEHHMCTALLVYMTQKLWRDRPLTAAELRNKSFMVNLLSLFSNPSEGEKYCDSEESTFPFREKEALMLPVKLPIYPFWIPTHQDGVEVCTWMSTLREKNCEPVARRSVFLRVRKRDSPGSGAAADAALRHFVEDALSFYFANGYSDQENYTLRMYRTTAANEKVLVQSVPLPLGPTLDTVFFPQRSHVKALLAHFLEKKGRYAIPGFPHKLGFLLYGPRGTGKRSFVRALAYHTRRHIVRIPLSRFTRSDQLFSIFYFHSVLTDSAEEWALLNSKKVIFLIEDVDTSDDLVRTRGSEHVVRVRRSRGLTTRSSQRAAENGGDAKTVDAAVLALQNGSPQVKALDTVEVATRKVARVLPPTSALKAVGWERLLRCQENKIDKLNLSSLLNVLDGAVEDPERIVVMIADHPEQLDPALLRPGRLTTHLRFDYIELDDLLRLCGLFFGAEYSEASSTLTTTGEANHHRQRDGYSNGRMVTSPATPPQQVHDGLLETTERHRAKPQSPIARVLKEKTNDAGLLQRQGLGFSASMTDAKIKERVLRQLSLKQATQVCSCISTLEEEASSQAPQARENTAYNFLITPAHVHHLCMHAANLNGFLDALSAYIRNGSGCDTCNRGDAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S6F1</accession>
    <name>A0A088S6F1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">META domain-containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">META1</name>
        <name evidence="2" type="ORF">LPMP_170880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697779.1">
        <property type="nucleotide sequence ID" value="XM_010699477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S6F1"/>
    <dbReference type="SMR" id="A0A088S6F1"/>
    <dbReference type="GeneID" id="22573831"/>
    <dbReference type="KEGG" id="lpan:LPMP_170880"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170014700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_170880"/>
    <dbReference type="eggNOG" id="ENOG502SGZ5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="258733at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005184">
        <property type="entry name" value="DUF306_Meta_HslJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038670">
        <property type="entry name" value="HslJ-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03724">
        <property type="entry name" value="META"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF306" evidence="1">
        <location>
            <begin position="7"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="112" mass="11926" checksum="1B94BABA47441610" modified="2014-11-26" version="1">MGIEDLHGRYTAKLMDGVPAPAGVTVEFSAGANSGAVRIHARVVNIMNGMLKVKENKLSGSLISTMMAGSDDLMAIEGIFLQGFMSGVTYTLREDGKLVLQLKSHTIEFVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S7E3</accession>
    <name>A0A088S7E3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vacuolar fusion protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_200040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698203.1">
        <property type="nucleotide sequence ID" value="XM_010699901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S7E3"/>
    <dbReference type="GeneID" id="22574211"/>
    <dbReference type="KEGG" id="lpan:LPMP_200040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200006600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_200040"/>
    <dbReference type="eggNOG" id="ENOG502SHRT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272411at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043971">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004353">
        <property type="entry name" value="Mon1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027">
        <property type="entry name" value="SAND PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027:SF7">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN MON1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19037">
        <property type="entry name" value="Fuz_longin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="639"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 second Longin" evidence="3">
        <location>
            <begin position="314"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN97496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="680" mass="74586" checksum="378083FCC518EE88" modified="2014-11-26" version="1">MAVNCTTALVTTESGSDTRNDPMTILWQHERHVLVFTRAGKPVFSQHGGEEQLSPLCALLQVLLHIQEGEEGGSEQSGRLSQPAPRSDGAAFSVSVKDEVRQVVYYQSRPTPGQISHQGDVSGQVQALTFFFYVQGELMYVMAVRSVDSSPSAGTVEMSRAQGDCKPPPVASYCQAQLRHVHHCILLVLPTISDLLTRSPGLDVMATYTSADRAALRELIESYQTELTYAVGAVATLALSVEKRRVVEEALLRCYRSCADAAVGPPAHQLFSFLYFKNYLVAAVGPPETYNVDSNVDVSAPLALGPDTALCGGLHVDDALLLYRYARSLVSRQPGEAWVPVCLPRFNSTGYLWCYAVNLTHYARELRQQQGLTVWPKVWEAHAELDVLLLHVSASQDDFTALSRSTRRFTQLLYAPAVGDNFFYRLEEELYHRTPAPLTELLSLSRISFSTCSSYDVSGRTGGVPLWYGVVIQDSDAAFLNAAQGKYAKAATWAATATKRTLDCPSASIRLLFESQPSPWLDLTTVEDGKEFRQLLSRYQEQLRAAPASTAAPCMLFVRHNNAIAFALIQPTPATLATLASHFFSPKNPFGVPSDGGIAGCDAEEVCHEDRGRAAAASHCGVSYSFWVDAVRALGVTELMVVFAAATPEAMAWYWVAHLLFMAVQRRGRFVVRQLIGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S8V4</accession>
    <name>A0A088S8V4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_205700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN98061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698768.1">
        <property type="nucleotide sequence ID" value="XM_010700466.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22574782"/>
    <dbReference type="KEGG" id="lpan:LPMP_205700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200064300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_205700"/>
    <dbReference type="eggNOG" id="ENOG502S2AT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272741at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2042"/>
            <end position="2066"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1663"/>
            <end position="1684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2109" mass="223823" checksum="BCC359F5DB2B3E51" modified="2014-11-26" version="1">MAKETQHDLPTLVSLLQATEVEWNVSAQHLTNSSTTGSCISSSNSSGGMASVRVGGQYLRYAQVLQCIDELFADLRMRSSAALAAWCASLRKDDISSHFGALIVGHVLQGTLPYVTLQRCLRLMDTFLGWVTRPNAGSADLGIGAAGPRCQALVPSCDVVKWIEQTWATVTTLSRDNAGTSSPTSTASLCGALQLLPILLRWNLAESPLPPFRRVQLPHPANMLSLEARLLALQVLPLVLQHQPSALGIQACTYEMIEYIKRACTKAGELSVRVAVGSSLRGLLEAGLRVASPTVAYGLMDMLLVLCDEASLHGVADEELHDVGVVMGYLLAFYQFDFTLNVLADVLHASAASTSKSAGEERVGHRGAGGGGSGRVRWQFFGGSDAIEGSRVVQRIFNERMSRTAQRTLATALATLCSCCATTATTADAIQCCFVLLVPAAADARAYMPRLLADAIVEWAALLPSNGYRVVLANALRKYIQRSGEDKAVARTAMVALQGVMRTLTSSLEIGFNVAEDVLAAVQTTPSLLSAGVEVLAAVARTNVLYARYLQHQCARVDSAEVANVLTFQLHVRALLEASSTLRAGPASQGHALGEEDRVSLVHNCIRLLLRLSRGDPPRIVQNIYYRQAELIFRLTHLLYDLLQGSAPAVLGAIRDVVLPCTVGFMNLLVVNPAPAIAYYKAVATACAMLRRAPVISDMERMLAIGFLEARFALPYSGTKHDASAAASSAETAYFAISRGSVFELISSNPWPTCKDDGSLRWLAAQALKDIATACTQGVPVLSFVDVCGTMIASAAQSMRLLRAEFLPHPASEELSGASSAAAETPAHPVEECGGHAVRLLRWTLRHFVQRADAAGACIALLTSLRTELYEVYSTPVSVAAAESAEDEAQRALRRDVALWNCLCTVEQLLQEASSRTAATLWQNVEWDAEVKQWQSVAAQLVPSIVCVSVEVRLLAAKVLGRCLASTDHVDVYTSQVMSSATQGLAKKSDQYDALGALLALSEVHSCYKECRAAAVISASTDSDSSPTLPLATSLLSNAWKQLTSPTPAASDSAIRSAPLLLLFSLRLARAYPTEVEAALFDNIVAVLLAPMAAANRIWWSPESVLGTLTAVLQLWAAFPGNGHGVSAVQHGTALALLQQTHVAALQWQRASVSTVVAAALDAVHTYTLKQQREGGQEALAGTREGHNSWHALLYQCLDHMTLIPPEEASAAFRPNVRERGQSTALRRRVVSDDNVSRRLAVLWKMAIEGATDIDSSVARGNVRLLSPVDIAVQVDITIAAATRREWVSVAQSMYTLLLSQRSTSTPLEASEADLPLKIYLDGIRAVLQARSPDVQVDISKWGTDMFATVEEADAADTVRGGGSNSEDSKEYGEEDMSGILREVGGAGGGDSAEAVRGSMTSDLGAGGGRSAAASLTFDIAAKEAAMWLLYGVLHSISAWSSSAAGRENDDGAREALLPVVVAATPLVEVHPEVQMSTIAVLHEVLVAWGNATQRQGYSLQTSVLLQWKTQLVVGLTAVLQHGLLSLEECAALAVQYSRCNMADPSSCRRVLRSLLMLLHACHRLHERGRGFLLIGGSGTGSIIVALTKVAQASAMNPAGSGSAGDGAADAAAAEQTQRNILHSLTSAPCQASLTLLCELLVRTASLANGYVQSADTVGLGWRGGGGGSGDSNDEEDGTSATSGVCASRTSISAGDVLQAVAFLTQEPLKMVLGPALRYASGCLAVLVLSTLVLPATPPPPPDGNPSASMTALRSMVVLSSQLTSNHQRLLAQLAQERLGTSIEKRLSSAQSLQSAWGTVDMELLRIVTVAPASRDTAATLLERITPVLSHYAAGGWRAEVAASLLHMGMAASLELNGLLSILSALSVESLLSDVPPESLDRLRQAFRSYVRSGGPTRARALALASPAGLLLSEQCATSDDATDVCHSLLAHRAAWPVVLQLLWEARDPLHVVTVMWSSTLSLAHTTPSSSTSLRDQVPQHRLQAEVLLSILASLGTSAASNTGVDEAVVLVLLRCGRLMCELLLGIMTSPEGHAAAPDTDALYTVLTYLVVVLCTPLSVAFAVALKPVGLHLIRTVAPSAGPVLREAIRRLGPTKAMQLRSFMEGSCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S9A6</accession>
    <name>A0A088S9A6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">40S ribosomal protein S23, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_211260</name>
        <name evidence="6" type="ORF">LPMP_211270</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698912.1">
        <property type="nucleotide sequence ID" value="XM_010700610.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698913.1">
        <property type="nucleotide sequence ID" value="XM_010700611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S9A6"/>
    <dbReference type="GeneID" id="22574948"/>
    <dbReference type="GeneID" id="22574949"/>
    <dbReference type="KEGG" id="lpan:LPMP_211260"/>
    <dbReference type="KEGG" id="lpan:LPMP_211270"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210016900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_211260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_211270"/>
    <dbReference type="eggNOG" id="KOG1749">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="238830at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03367">
        <property type="entry name" value="Ribosomal_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000007">
        <property type="entry name" value="40S ribosomal protein S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005680">
        <property type="entry name" value="Ribosomal_uS12_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00982">
        <property type="entry name" value="uS12_E_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN98205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN98206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="143" mass="15918" checksum="376079F1182C21BE" modified="2014-11-26" version="1">MTKTNGQNAARKLVRLRRRNRWADKGWKRAHTFAAKKANPFGGSSHAKGIVLEKIGVGAKQPNSAIRKCVRVQLIKNDKKIIAFVPNDGCLHFIEENDEVLVSGFGRSGHAVGDIPGVRFKIVKVSSVGLYALYRQKKEKPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SA24</accession>
    <name>A0A088SA24_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_230450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699203.1">
        <property type="nucleotide sequence ID" value="XM_010700901.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22575249"/>
    <dbReference type="KEGG" id="lpan:LPMP_230450"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230009900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_230450"/>
    <dbReference type="eggNOG" id="ENOG502SI0F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265333at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="866"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1024"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1443" mass="156109" checksum="9D78FF94B2F2B9C5" modified="2014-11-26" version="1">MHPHLLSQSTANAPTMGVRPAGRAPAALASVPQHSSLTKFSRRLQARPATTSISPRSVATKVRGSRENTPLKQRVLAECRTLATPHRRTNGSPAAIPRGSDAPRVHVRINTAVSVARRCMSSLPRTTRRMAIAHPRRSSSVATPLSKKSRSPSRATPRSVSRLTTRPPQVPPNTRCCASTLTNAKQQHRPSAPRHIANAPSATVSHTCIPRPRHASTDAGFGGHVNEPFATYAWLPSSLASRENVEPLSAMPMPSSAFNRSSAAPSTRSATPPTISAATLRNVCGAVQPTSTPLQVHAAHRCKLHPGLTCSLRAASSIEPAFLVHEIPPASALVLPDSSDAQLRQLFATLFVRTSDSTWSLHRHILPFLAARQNCIMPVSPSQVAAFVGFADHSDGGVQVKERTGVAGDTHNERSLCDGPRITKAMSRFASQLCYWFVYVGVLGSSEAIHWDTLLMPLESTSAPSHRSFLWGNDTAGSTAAARAPMTRSNSPSVHPATPEKQPCCRSPHQSLSNFPAVSSPTQCVGTVTEVPIQCQHRRMPDDGDDDDEENSPTSTMLWHTDQLDNSTLGFAATSPVASVEFRSVVKVPPVVQEVVFVRGYKVLQALLANREAQLAHMKEGPMAALLRAIGTAAGADKRTSTNLEQSAHCLAEPHPSVIRTVYRRVRFYLRLHAFVRELCVYLRAHQARPWQRESYILESVVSSRLRVTASFASVDARMAGKAKMSAIAETSTGGGGRWKPVRDALVKGVLCAAFHAAPTRVSANSLQTLLVLQHADATRVVLRAAEVIRRDVTGEGLPHASNAVVASSSFPSSHSCEVSTSEGTTSSRLPVQLLRIFPLPRWSSLAQPGTASPKHATSFDLVASWALGFALALAVLSNFLFIFGAQLVWTLWWTTSREASANGDTAQHLHVLHRTWMLSFVKECSIILLLLACTARVAHRAGEVVASIEVTHAVVTAQSAALTRASEGWLQVAWALHSGNTVAAHAVQRCMDRLRLVGNAVDDFEAAPLGLRHALSRGMWSRYWFVFFMAALVTCTIKMSLHLGQYVELTAVVMLAWGTSVARVCETRQQRRRALAWWLYCQATTAESFAEDLLRTAGDRCSEALSSGTAADEKGGSAARGLLSSDCASLPTLCTISLPVLEELAKVACLVEWSEGRLLPRYQGSHGTSPANLAELTTQWFWEQLCGRAAPTYSKGVSSVAVVETTMWACRRSLEAEQRQRGAASLPVAEAVAYVLPWALDYEKALPPLTGALEGCHDYQVSEALAPFAAAASRDASAAAHAPPHRSFSPLSSHVFQENSAMDASLPLDVELRRLPYLSQLQGRLVVCTAFVLASLRAAPRAMSEAVGGCSASFSTYMGERTFTLLVYLVHSQLYVTPSLWCTKGSERASAARWRQAATRTRDTLQLLQRVTLLAQQRDVRDPPAGRAYATVLPSVLHALFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SBB5</accession>
    <name>A0A088SBB5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_250940</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SLBP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699663.1">
        <property type="nucleotide sequence ID" value="XM_010701361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SBB5"/>
    <dbReference type="GeneID" id="22575742"/>
    <dbReference type="KEGG" id="lpan:LPMP_250940"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250015400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_250940"/>
    <dbReference type="eggNOG" id="ENOG502S0S6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265795at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071204">
        <property type="term" value="C:histone pre-mRNA 3'end processing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071207">
        <property type="term" value="F:histone pre-mRNA stem-loop binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1120:FF:000004">
        <property type="entry name" value="Histone_RNA_hairpin-binding_protein_RNA-binding_domain_containing_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1120">
        <property type="entry name" value="Histone RNA hairpin-binding protein RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026502">
        <property type="entry name" value="SLBP1/SLBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029344">
        <property type="entry name" value="SLBP_RNA_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038294">
        <property type="entry name" value="SLBP_RNA_bind_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17408">
        <property type="entry name" value="HISTONE RNA HAIRPIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17408:SF12">
        <property type="entry name" value="HISTONE RNA HAIRPIN-BINDING PROTEIN RNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15247">
        <property type="entry name" value="SLBP_RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Histone RNA hairpin-binding protein RNA-binding" evidence="4">
        <location>
            <begin position="166"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="58"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="394"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="806"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="430"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="470"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN98956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="846" mass="89909" checksum="A9F60F892B876882" modified="2014-11-26" version="1">MQRQEQQQSLTTPLRAPRGGGDGSYVQMFLEQTPETFGVLLKDSQSLSPAPCFPSDAVSLFASQQRPGDHQHTGAPPSDCRPPSLQPRELFQAPQRRHQQKQQQHASPSCGAYDQQGDGGRCGSGSGSGASNEWRERTVSSNPRASRAGGNTRPHKPLPPGNSPDEDRRRRQREKQIQFGYVTDGYTNMKRLIAHDPLLRSGGILPLSPPEIVNGSKRQWDIQLRKWRRALHMFDYVFIDGEDDPTTRAKVLEEQRQQWVSEALNEMPREARLKIDLDTLRLVQHSATVPCRIPIEEDLRCILRNDGCYESLRSVVPQSASSLTKGTDISPIEAGIKIHIAPSAAVVQRQQAHLEMQQRLSSLHQQALATEVAVGGEETTSHVASAPPVLAATAQCADAQRPTELSPSPRRPPLPLQPTPHQQHCDNPRNKQNCSTLSGSPLSHATAAPTFTSLGNAETAPGLSASQPRALSLSGSSATGWGASPGAPGGSSTVAVLEPPLSFPGSPPSFAPHTRMHGVAAPPQASAAGVTMPTMAPPILPWCTHCGHRVDLPAPGIASAPYGGMGTGTAVAADRVPAPTQMRPQHASRAVIGGTCEAMMSPLMQLPSAMTCMNYPTASTAATAATSPLHWSMLARPMVEGVGSNETPATHHGCSYTQYCQFEAWQDAFTAMPRSAAAAVVGRSCLQNGHCRSSGAVATGGRSATQAVPRFVARLSALPNEQRLGEQQPAERPYSPDGVNDGVLAATNPLATDTSASVATPATLQQSPSACDAAVATAQLEKSQSVLAVTPERTLFGAGIMKEAPPVVGGAQRPHETQQDTPLGKPMPMPEVEEALGISFVFGTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SC17</accession>
    <name>A0A088SC17_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_261130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699933.1">
        <property type="nucleotide sequence ID" value="XM_010701631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SC17"/>
    <dbReference type="GeneID" id="22576016"/>
    <dbReference type="KEGG" id="lpan:LPMP_261130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260016200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_261130"/>
    <dbReference type="eggNOG" id="ENOG502SCFN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273889at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="785" mass="84277" checksum="CFFBFC4AF3BBACE2" modified="2014-11-26" version="1">MLSQPLSVWWSTVPRCHGRRCLISLSASASHSQHRRRSSQVATCYGHARTCHYSSHSLVGRRVSAMSSGVPDAPTSAAPWVRLVHLVLARSLSGQRSLPLKATDAPALADVAHVGAALPAIHKLWMSAYHPAFAVVASDSDAQWQQHRLLPEEAEELPLFVEALGQLAAALQALIVEKAEAAAESAAAAAAEGDDDDTATRLEVHEWFVELQALLLFIGQHHLRFLIPTTFSSALSSLVAASLVPETHKVDQRVEASDSKKLDRPRTEKPQEVVACDGSSLKQAAKEPMVGHTSALPVVVKGNVSGAAPLRRLSRRESEDVQHMAPPLPVEELLRVVVLVGAARTILDVANPPPLASGVRAEVYGVLLSVVSVSEQLSSTTLASLAACLAQCVDSYVTCQQLSAVACAPPEPAAVLGEYDVSGGAQAPREHFMDGRRAALSAFLRRVSLDVPAWVTGGSLTISPSPIEQQEAAQLERLRGGLGTRLRPTEVLHHLRILANVLQRRLAETLYHSETGRNTPQSHQEAERCCGSDAVVSVSSTGAARVAREARVEAGMLGILPLEQYKARLATRWSGAESTVTTQTRRKRRTVAAIRAAADRERVSEDNFAAHSTTNVSSLPVPHGRASPPSFTPCDSFQHPCIGYADCRATDDNTRVSLTDLAEMCSAMAAIGFRGDSTAAEEPMWRHAVEFACAEIVAMADARDAGDAMGHADDEDAADVAVDREAVIRQALLDTRDLCFALDWVGYTRGYDHVMAMLVRCGFLCEPIPAPSAVRRSMKDITCSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SCB6</accession>
    <name>A0A088SCB6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sec1 family transport protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_262330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700053.1">
        <property type="nucleotide sequence ID" value="XM_010701751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SCB6"/>
    <dbReference type="GeneID" id="22576136"/>
    <dbReference type="KEGG" id="lpan:LPMP_262330"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260028100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_262330"/>
    <dbReference type="eggNOG" id="KOG1301">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251230at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="566"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="688" mass="74439" checksum="A441297383D464C1" modified="2014-11-26" version="1">MFTTSSSLMGGASGPSSRPPGGVFAGAVAARQPPSQYWLRQRQEAVLAEMIKMAVPLDEEGNLVTEPFSTAAAASAEPVITTWRLLIFDDWGRDIIAPLLKVGQLRELGVTLYLHIATERDPVPGAPAIYFCAPTEENITRITNDCAQGLYEWVYLNFTTQIPRPQLELLAQQLSASPLESIRHIHVYDRTLSYVALENDLFSLMLNNSFPLLNKTNAKEDEIESHLNQIVLGISHVCLSLQVLPILVHSRSGAAAEVARRLSVRLSDALNDRQLTPAPSSVLGRPLLLIVDRSSDLATALHHPFTYRGLLVEIGGMKLNRCVITTPDGKDEVLEVDPDKDEVYRENASVEFGTVGGNIEAALRRYKEDYAVLAQETPGGAGGMMGDGGDGNDMSKLLANAPALAERKRYLDAHTKLAFSILSKIRSRHLDHYHGVELAILQQEGLDEQEFHNLMANNLGTTEDRQRLYLIAYLMCAQEEEIRYVRSHEDAVSEGATAFPALDYVKHLRSWSLTPQSPSAAQPNPSQGFGWGFAQQIAKNIASSLGSKAETMLPLTKLVDALMQDRPGGAPGAAGSSGASGVGGPYGSPTSAVLPGGNASVSSGLRAKLLETIEAYDPRTKKSVDLREAVFSQAIVFALGGGSVAEYDNLKTWEASKPRKSVIYGCTSVVSGEDMLRQLSMLGASQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SCF6</accession>
    <name>A0A088SCF6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_270060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700093.1">
        <property type="nucleotide sequence ID" value="XM_010701791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SCF6"/>
    <dbReference type="GeneID" id="22576182"/>
    <dbReference type="KEGG" id="lpan:LPMP_270060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270006000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_270060"/>
    <dbReference type="eggNOG" id="ENOG502SGYM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="263315at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="70" mass="8497" checksum="D3AD2B53D7E8D356" modified="2014-11-26" version="1">MPRVYQKSEIDSSIFSRIVEQGWVAFFILGILMIGLRVYNVKQRRDQRKLLREELMAEMRYRSMASRKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SD27</accession>
    <name>A0A088SD27_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-oxoacyl-ACP reductase, putative</fullName>
            <ecNumber evidence="3">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">KAR1</name>
        <name evidence="3" type="ORF">LPMP_272470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="3"/>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700333.1">
        <property type="nucleotide sequence ID" value="XM_010702031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SD27"/>
    <dbReference type="GeneID" id="22576425"/>
    <dbReference type="KEGG" id="lpan:LPMP_272470"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270032800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_272470"/>
    <dbReference type="eggNOG" id="KOG1200">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000872">
        <property type="entry name" value="3-oxoacyl-ACP reductase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF133">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="241" mass="25200" checksum="32BC56ECA581265B" modified="2014-11-26" version="1">MVWSVCGKVGVLTGASCALGHEIMERLASQHRMKLACVSRRPFAAPLPAGCAAFVADVSRGDDCDALMKAVQCELGAMSLLINCAGVTLSKLHLTCTDKDYAAVMDTNLRGALQVTRAALRHGGLLKLQDGAVLHIGSLAGLVGNEGQVLYSASKAALSGAVKSWALEYGPRNIRFNVVAPGLIDGEGMATSLNEAQKQRWRDNCPLKRLATASEVADMAVAVALCPYMNGQTIAVDGGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SEH0</accession>
    <name>A0A088SEH0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-GlcNAc:PI a1-6 GlcNAc-transferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_292050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700809.1">
        <property type="nucleotide sequence ID" value="XM_010702507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SEH0"/>
    <dbReference type="GeneID" id="22576968"/>
    <dbReference type="KEGG" id="lpan:LPMP_292050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290022700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_292050"/>
    <dbReference type="eggNOG" id="KOG1183">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="70250at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007720">
        <property type="entry name" value="PigQ/GPI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329:SF3">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05024">
        <property type="entry name" value="Gpi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="629"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="700"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="741"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="880" mass="98210" checksum="A927C4C7A3AC98E2" modified="2014-11-26" version="1">MPRSSTTEICMLVWPVSPATQILGANDSIAWVVGWNDRRLYIIVTWFLRNCTLEEAKAELQKIRCVLQNYNGNMPEMPYSSLTILGCVRPSSTSHGSNLYSVAEEEDIRDARRSSYLWLELLEGPVLAELWCCGARVQPCQLHVVRCDPAKALSISPTIFSATALYGVSGVRQLQSGIVPVCAPGASSNLEGVLLPGVMRKEAGPRVLKRDQQRWRNTSFVSDSITMPAEDSFSDRDTVEQSGVLTGRRREMFVNSNISFATHSNSFGEDALASPEWHRNSSLRDRLAAGPEESFTPLEGDDSGVTAPVSTATLSDSEIEQVDSGDRKRGWRSSSHFEKHRARSTLAPPQSIAPPPPAGVPPRLDFTSTTDRAEMSILLATMRAGRNVRRVMQKEELDNYVKEETVEPLTGVLKYAVDFIFSYVISLLKLLRFSKTAELLLYRTSEFVHFLCAVSFANDSCGLHPVLPHQVSPYANRRYVCIFGYISRCAVDLVLGVLVYLCVSAWGPSLFVASQYVARHCLYEMHAAYMDWFDGYPAGLKVNEDLNMALCFFAKCVLEVWDALLRWSPATLPSLVSFQSDSFAVEAYVNSTVAAVGTAAPLSTLSYPASEDQLQAVYEWIRMSLHLRIFCLLGCSTAAALVSDITGLVSLHLRFLYHAVALPYRFARVLLTNLFRQFYGVKYNPLRKRYDSYHFQVDQMLAATFLFVIISFLFPTLAVYYLYFSFVLAMIWYTETCMESVAYLSLHVPVFPIVYWLWMRHQLSGGVALSSPVITSVRQLLSCGSRSGSHEEALASHTVEVTVEALPLPLSLMLTDFFVVVDIIMTRLRPTKVALLVLHGRMAYSPKMTDVIGPHLLTNCVSPQCTLCTPPPEKVVLKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SF31</accession>
    <name>A0A088SF31_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_301870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701212.1">
        <property type="nucleotide sequence ID" value="XM_010702910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SF31"/>
    <dbReference type="GeneID" id="22577240"/>
    <dbReference type="KEGG" id="lpan:LPMP_301870"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300023000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_301870"/>
    <dbReference type="eggNOG" id="ENOG502SMFU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264963at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="646" mass="70437" checksum="C9B9A918E030206F" modified="2014-11-26" version="1">MPPLGPGCNAVESSSLNARAYWQPQATNSPSLRTGPSAGTAAASTVTTTATVYRSGSATVFERLAGESSIGISMIGKRVRQWAEGAGLMLHPSNSVWHALLTYSMAPLKYERLWRRTCAKGRYRLSLLTRPKVCNGTSSAAALREHDVAEERSHADPHQKATNPGQRGRARRHSIPSTTPGGLSAYRVQQEYMRWCQWQLWHFFEQGRSYLTSVWRVSPLLWRQRRHAARCCGGKESTTTSPASSVSLIFDGRYTVPSVASIDAAQEEHRTLEKRVKVLLRLLRRENGSSAPASTTRSCSRDNGSNGAATAAHGADDIAASDPDGEGEEDWEEENVYRSANQRRHRSEAVAVTQPFLDVHIDEATALMHLSLYINGDANGNGAEFVGSSVAGCIDNHRWVILKGLWARQVLVFCFYRGEGLPSTTKKQVDGHLKRQGGYDEQTEQDVSRCSHIVEGLVVKGVAFTKMHPGHTLATAQDTFACTRCGHKRRCHNVAYTSKQTGRIVCGVYYCVVCLTRTHHVCIPPMKDLQTVLLGGSEAGAVEGSRVHQLRGLSSVRSSASFSRSTNTTGSGLLPSAYAHWCSGSGSHAADAPQFAVEDAATAMREWTRAAAAAPRPAWLLGSKLNSDELFGRTRGLDCPPPRPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SFP7</accession>
    <name>A0A088SFP7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-dependent RNA helicase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_310250</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701417.1">
        <property type="nucleotide sequence ID" value="XM_010703115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SFP7"/>
    <dbReference type="GeneID" id="22577451"/>
    <dbReference type="KEGG" id="lpan:LPMP_310250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310007500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_310250"/>
    <dbReference type="eggNOG" id="KOG0920">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="66977at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001737">
        <property type="entry name" value="ATP-dependent RNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001780">
        <property type="entry name" value="Putative ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF111">
        <property type="entry name" value="RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="353"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="565"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="91"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="232"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="272"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO00617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1190" mass="132423" checksum="4D2CC78F0091CF95" modified="2014-11-26" version="1">MPRRPGPQIKRASDKENKDGAGTRSDTVKVAVTPPAPTNEQWSTNKQGGNVLQWLAQKTDATAPAPTSRGAVEYLNQAKKPKSYAAAAALSGAKAKPSATAEKPAEKAVDQLAAKVPRSAPAKEPVKTGKRDAAKAASKELTKVVLKDTVKAVPSKVTPKEAPKSEAQPPAAAAAEFSAVPKPRSKAAPEAPPEPKESDGTAGNLAQLAPAKAMGALTGATKATDELVKTAELPTSATTHLLSKPAPRSSASSLANNVRPEVPPPRRVRGRRRDDDRAVRAQQRIEKEQESAQRRHAEAMRTDAEYKQRFETMQEMQTAMQISQAEFFDKYRRQETLLLNHVVTERLDMPVILELIEQHDVVFVCTDTGSGKSTGVPKALLELSSDTKVVSTQPRRTATVAISNRVASLRRERVGEDVGYWIRGDKKGDEQTRLWYMTSYTLLLRILENPAELPFTHIVLDEFHERQPDLEVTVALLRLALLNKTSHFKLVLMSATLNTEDWEEYFAGLRVATYKQSEPEHPIHDYFLEETCTLLGTDYHAPPQLVSRGVVDKGTVEKHFYLAQNLIFFLNSCSNPVHSILVFLPGRAQVETMSMWLRTQLSHRVDAVPWHSAVNLSEIEAAMRRHIPGRQKVYLATDIAEVSITLPDVVYVIDLVLVKRPKISKESPSSIQYPPLVTQWISRGSVAQRRGRIGRVQQGFYFCLFPAVQITDLPTYSQPPIENSRIDELSLHCLQVVSNPVAIFSLCHGQPLVGVIASSMNMLTQLGCILDAKDPLSAGERIDEIYNRQNESWSRMIMAAAQAEVMTDIPEYHCTFIGRILQLIPVSPQPGMLVFFGFLTGLESLMILAAAVTSSLSPFSINANEGRQRHFNVARAMEETENAMREFCCGLRSDIVAVMKAALLFRIEQQRHGDSMETVRHWCLQKYLSYDKLMAIVDLENHIKYELAEFMPFRSIVEAEKLLEQLDKLASMVAVMTNVAFVAQSLEVTSENNSYTNSKEMALGIFSDLTAVPDIHSPSCLRWQEGDVIIPVQLSLIFDKLLASFSTAIASPKQFWMSLLLFSQRVHYATFSDDEGTFHVFALSYGGKERYVEVDEITGYVVLEFRRKLSAICGVLRLTHANRLLYEDHINTLLSSYSLAPLQDLQREVITALVSIFNNLEDMTADEVEHDEDDLDLVSLLSFVLPTRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SFU1</accession>
    <name>A0A088SFU1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_310480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701437.1">
        <property type="nucleotide sequence ID" value="XM_010703135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SFU1"/>
    <dbReference type="GeneID" id="22577474"/>
    <dbReference type="KEGG" id="lpan:LPMP_310480"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310009800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_310480"/>
    <dbReference type="eggNOG" id="ENOG502SGYK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273656at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="582"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="648" mass="67822" checksum="50E3D29E436F967D" modified="2014-11-26" version="1">MRVGCANWQNRGATEMPNSGDPDATSMPETSMSPNMNATKAAVSASGAQTAHPAVDATTKGSRRAQGWHSAVTGGAPPRTTSANRPASDTKSLGGSAAHSGIVRRSSVQFSKDSLVSPNSSRIPRDEASEFRQNMTDFLMVMYGDKTASGVVGADEKNGAPRAKGKVDPGESRIPGALLEAGREPPWHAGSSRGVSSRSQGPLVKGLTANSGRSPQVDRIDTLVESLVRAYSRRTTSARGEFQGIPGVDDDNPITYNGPHPSSCRRALTSPRLSHGNSIGTGSGHTDEVSAFVGQALDNILNPGGILGQGAVSSLSMLSSLRLDRNLFDLMPFQTQSNLQNVIAEEEDSGTMLKPMYVGEQAMFRSVGTRPSITDISVSKSMRGMIPAAPPESGKGHHLNTTQAPLCGDSGGPPRSSRGPSLCPPKQTLGDKKRSLDSEVMENAFVNQRGSGAVGGDAKNKSIVHCMSLDSKVLGRAVGADDEDDSWGDAPAGILATKATDSGSPGMDSSDRSLLDYSRARANVTLQKALGTLQMEEQLKRDVVIAVEHQLCGYITSLEHEERLKKRGGSAASSGQQKRGGETSASSTPAAGSSMITDGVVGAGRNTRSRGTVNSDTAPLMQNIIDFFQENTTEVHHSNTLASAAAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SHB7</accession>
    <name>A0A088SHB7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_323120</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="1"/>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701997.1">
        <property type="nucleotide sequence ID" value="XM_010703695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SHB7"/>
    <dbReference type="GeneID" id="22578053"/>
    <dbReference type="KEGG" id="lpan:LPMP_323120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320037500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_323120"/>
    <dbReference type="eggNOG" id="KOG0482">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3207464at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17758">
        <property type="entry name" value="MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000501">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008050">
        <property type="entry name" value="MCM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF26">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="7">
        <location>
            <begin position="330"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO01197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="725" mass="80362" checksum="66A4E10F27FFF1EF" modified="2014-11-26" version="1">MSTPDKRAYATAASSKYPNYINDRDLCKRFLEGFRDSAGQPKYVIQAHHVAQRQCIVFPIFLDDIAAFGQLHLAQRIQMNVVGYMEELYRVVDYIIPQTDHVVDMVDQLVMEARMSGQELPAPLTRRYELKIHPLSESSIPIPLRELKGGTIGTLTVLRGICIAATAVRPKLSILVSVCEVCAETTFQQVIGDRLTPLQVCQSQRCKLNNAVGRLLAQNKASKFLKYQELRVQELPEDVPRGAIPRSIRVICEGEQTRIAAPGQVVRITGTYCPDPSTGQGHEAFRASTMVKTLYKAIHIDLEKRSYQEAADNMRAQVEDVRDYPDREAVIEKLTRSIAPEIWGMEDVKKALLCQLVGGSSITNGIRIRSDINILFMGDPGVAKSQLLKWIASVAPRSVFTTGKGSSGVGLTAAVTRDTHTGEVMLEGGALVLSDKGICCIDEFDKMDDSDRTALHEVMEQQMVSIAKAGIITSLNARTSILAAANPKFGRWKRNATPTENVNLPPALLSRFDLLWLVLDESSRERDTELSMHVTHVHLHGVAPGKVADDGVRGTTTEYFGRDFLRAYVGEVKRIHPYVDPGAAKAISDIYCEMRAQSVRHSNVVTARTLLSLIRLSQACARLRFSERVLEEDVREAGRLLDCSKASLQDRPVTDMHRVVTTSDASIFSTIRDIARGRSSVDLSEIRPALVMKGIGESHLQRCLRTYCEVGVWSVSGTVLEFADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SKC9</accession>
    <name>A0A088SKC9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heat shock protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_351340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703072.1">
        <property type="nucleotide sequence ID" value="XM_010704770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SKC9"/>
    <dbReference type="GeneID" id="22579163"/>
    <dbReference type="KEGG" id="lpan:LPMP_351340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350019000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_351340"/>
    <dbReference type="eggNOG" id="ENOG502RZUX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273032at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0346">Stress response</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="87"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO02272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="364" mass="39198" checksum="A72C17345AC074F5" modified="2014-11-26" version="1">MWRTRRPRTSAASATFQVSSRQVMCCRAVLRTRASFVSGAASTHGCVPLVAVRRWCVTTRQRGSAPSGAPSTDGEAVVRAAKWNSSNFEERLGFSAGETITEERLKRHYYLLAKHYHPDTAAGSAGSSGAAHSSEASAGSAGAFQNIKEAYDVINGTLRRGGRWGGNTSGGSSAAEFARGFEYSDGARRRAQMRLLGDAVLLFMFTTVAFIIIVSGHNKSRMQSRYLWHLVGIFFIIQLFPRLLAAAILFAVHSLYLLERATLQEQAAISLIVERTERACSVKLDGLSAEAQPHVVVQVTTTAESNAAAVEAVSSTLTFDKGITAFTLPVPVDSSSVYYIKAVDEARKIVLVDRALSAGMQAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4J4</accession>
    <name>A0AC62A4J4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3420330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="XUY36797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="748" mass="80610" checksum="79B6C7EB7D87A0D6" modified="2026-01-28" version="1">MSHYIEACRDDERFTARLEEATKEMGGLLLKTSRTRHELDRMAAEVRMRGPLHFYPCNIADCVDLAPSTFAGERLAPPQVRDDLARNMLSAELAQWARWHLPSLVAPLIEAQVQQRLLSLRDSVDELRVRQAKVEKAAKDATERVHVHRADIHADFAASQEEMQRDLEEHQRGVKRQIAAWSEELRHVREDVLALGQQRVSASDRQEQRISGALQRQQTHVQETLEALEHGLQRWRRAMSRTVQKETQELHAQHRVLENRVAQAQGMLTSTADMAARCTAETRRLMEDAMCRSSEVRVCRRDVNRLEMLVQCSSLQTALLTGGAGSSDSNDSSTAPAAASVVLNGLTQEMARFSDSLHAMVHRVDGLDRHVRQLEMAVARSTAVSCGQGTYHSSMRGVDEESSYGRSFASTSRPSCSYLSKATGLRGRCASAGEARAPSPLAQNDSSDVAPIHNGGAAAKPRTTSITLVSATQPVGMGSALGGGHYRTAGPEVQLTLTPLMSASPSSTTYHLPASHLSGSSLRFEDEAGDSHSTPVIVSDARPAPDVEGDRVLLRSAAAGTGVQQPLERRATAHATPAKTVEGDTQLGGVAKPTAAKTVAHGMPLPLAAVDASQIARQDVAPSLTHQYDASSWPAASALSAGNADVTYLVKRPSSCLATCEAVAVAEDVALKRQSGSDHAERPVVATPCSPVDSYLSDTPAADLYNSKANVASAPKSSTPEIAQYTPAQASDSESERDNHVIARSALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4P0</accession>
    <name>A0AC62A4P0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Heat shock protein 83</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">HSP83</name>
        <name evidence="1" type="ORF">LPMP_3320010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="XUY36709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="704" mass="80794" checksum="63C432B9856AE93D" modified="2026-01-28" version="1">MTETFAFQAEINQLMSLIINTFYSNKEIFLRELISNASDACDKIRYQSLTDPSVLGEETHLRVRVVPDKANKTLTVEDNGIGMTKADLVNNLGTIARSGTKAFMEALEAGGDMSMIGQFGVGFYSAYLVADRVTVVSKNNSDEAYVWESSAGGTFTITSVQESDMKRGTRITLHLKEDQQEYLEERRVKDLIKKHSEFIGYDIELMVEKTAEKEVTDEDEEEDESKKKSCGDEGEPKVEEVTEGGEDKKKKTKKVKEVTKTYEVQNKHKPLWTRDPKDVTKEEYAAFYKAISNDWEDPAATKHFSVEGQLEFRAIMFVPKRAPFDMFEPNKKRNNIKLYVRRVFIMDNCEDLCPDWLGFVKGVVDSEDLPLNISRENLQQNKILKVIRKNIVKKCLELFEEMAENKEDYKQFYEQFGKNIKLGIHEDTANRKKLMELLRFYSTESGEEMTTLKDYVTRMKPEQKSIYYITGDSKKKLESSPFIEKARRCGLEVLFMTEPIDEYVMQQVKDFEDKKFACLTKEGVHFEESEEEKKQREEKKAACEKLCKTMKEVLGDKVEKVTVSERLSTSPCILVTSEFGWSAHMEQIMRNQALRDSSMAQYMMSKKTMEVNPDHPIIKELRRRVEADENDKAVKDLVFLLFDTSLLTSGFQLDDPTGYAERINRMIKLGLSLDEEEEEVAEAAPSEAAPAEVTAGTSSMEQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4X4</accession>
    <name>A0AC62A4X4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Beta tubulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3320230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="XUY36731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="443" mass="49744" checksum="1E1DE6A6BC45CBBD" modified="2026-01-28" version="1">MREIVSCQAGQCGNQIGSKFWEVIADEHGVDPTGSYQGDSDLQLERMNVYFDESAGGRYVPRAVLMDLEPGTMDSVRAGPYGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELIDSVLDVCRKEAESCDCLQGFQLSHSLGGGTGSGMGTLLISKLREEYPDRIMMTFSVIPSPRVSDTVVEPYNTTLSVHQLVENSDESMCIDNEALYDICFRTLKLTTPTFGDLNHLVAAVMSGVTCCLRFPGQLNSDLRKLAVNLVPFPRLHFFMMGFAPLTSRGSQQYRGLSVAELTQQMFDAKNMMQAADPRHGRYLTASALFRGRMSTKEVDEQMLNVQNKNSSYFIEWIPNNIKSSICDIPPKGLKMSVTFIGNNTCIQEMFRRVGEQFTGMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATVEEEGEYDEEEEAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A507</accession>
    <name>A0AC62A507_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GPI alpha-mannosyltransferase III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">GPI10</name>
        <name evidence="1" type="ORF">LPMP_3520120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="XUY36844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="622" mass="69988" checksum="45C56E2C6EA5A26F" modified="2026-01-28" version="1">MDVLTVFSLWPRPLRSWRVLAVLLLYRIALCLTLRTAESPDEWWQSEEVAYHMVFGHGHLTWEWHELIRSYVFPAIFACPLFVLKCTGTDTAMTVWAANRCVQAVIFFAQDCTMLALAQRLDDLRCGLDLSTSGRGAGSFSPSSAPSSSTKTAGGIPTIASTTLAMLVVEWFLNNTGVRGYSNVAESLFFLLSLYQARYSTFLLCAGAACAVRATAAIAVLPVFMVHIFRLCRRKGIARGLAVLAPLTVSALASVSAAVCLVDYVFYDRLVFTPYKFLKVNVLMGVSKYFGVHPPYWYLVVLPAMAAPFAFFLAWAPVCWKRMQVAEGHHVSGSTRYADHTLLTCTSSRTLRQEIKRWVFVGVLSLMFYSLVDHKEMRFVYFLLPILLVLSSVVVVDLCTSSLSAQKNSSSVQSVRWSLVVPSAATVRRLFTLCWVANAALAIVLLHGYRCGSLTLWRKIRDADWHFSHLEVLTPCYATPGFAQLHGKVDRLELVDCPVKLDPVLGVREVTHDLLFREQQKAYALWRYLRLPSKLDVEEVGMESEKKLSKGAWWRGAHHLMPAAEPPVLPDGIVLFQNTAISLEADLLRPMGYRRIAVVFHTPYNFEKDEDRYLELWSREVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A542</accession>
    <name>A0AC62A542_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha tubulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1320060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="XUY36977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="451" mass="49683" checksum="3D47FCCC1FBC5BF5" modified="2026-01-28" version="1">MREAICIHIGQAGCQVGNACWELFCLEHGIQPDGSMPSDKCIGVEDDAFNTFFSETGAGKHVPRSLFLDLEPTVVDEVRTGTYRQLFNPEQLVSGKEDAANNYARGHYTIGKEIVDLALDRIRKLADNCTGLQGFMVFHAVGGGTGSGLGALLLERLSVDYGKKSKLGYTVYPSPQVSTAVVEPYNCVLSTHSLLEHTDVATMLDNEAIYDLTRRSLDIERPSYTNVNRLIGQVVSSLTASLRFDGALNVDLTEFQTNLVPYPRIHFVLTSYAPVVSAEKAYHEQLSVADITNSVFEPAGMLTKCDPRHGKYMSCCLMYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKCGINYQPPTVVPGGDLAKVQRAVCMIANSTAIAEVFARIDHKFDLMYSKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGAESADDAGEEDVEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A562</accession>
    <name>A0AC62A562_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3420590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="XUY36823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="506" mass="55773" checksum="412B050E9AD10102" modified="2026-01-28" version="1">MPTCSSATVTGDSRSCACAVLPTIPVRPPLPRATMLGRAGNTCTSAHPRSLREAAMPPRGDAPRCARQRHCLTHDTTLSHPRKDADRAQAISGINHSSSLNSTAHWPLLGKRGCSLWALSPATQRRSSPAPAAAPEAVPLRPPHPPRSPPYALGCDRGRSSDNDCSIFPPPRALPLYTTEEELPVCIDPEGVRCCPLLNPQCEEGVVTAAQINLSPFLNWKFVPYLPPQAEDQARSTVVLDMDETLLHTSVAPMPDADAEIDVPYPSDDARDVKASVTLPHYKLFVKYRPHLEQFLLFCLDHFEVVIFTASKALYAQAVLRQLQEDFPGIAIRLDDNNLSGGAPASPHARGEARIIELLHRDHCTPTNVGYTKDLHLIGRDLRRTILVDNRKVCGVFQPYNAVHVKDFARRRCAERVPEEQKMQAMHLRQLERTIPASAVEVAEDVATSRLLSTSGCSTSTYDWEDREDTVLLHLCAPGGLLHCLSRCEDVPSFLQRTMRFNRAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5K6</accession>
    <name>A0AC62A5K6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histone H3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1620280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="XUY37039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="66" mass="7238" checksum="D87F239EB5F19D1A" modified="2026-01-28" version="1">MPCARCRACRRRGGPALPEQRDPGDPGGVRCVADGCHEPGQHPREACVTVRPKDVQLAVRLRGERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5P5</accession>
    <name>A0AC62A5P5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Receptor-type adenylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1720200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="XUY37110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0675">Receptor</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1406" mass="152048" checksum="090C193B078D2FF1" modified="2026-01-28" version="1">MHAGTPHPRRICGRGAGGVAGGLKRLHTYRRSPLLAAALLIVGALTLAVFTAPTAWAAGAGILSEEPVYLLNAMYSMTDYMASYAEALWLGIDAALYNAGYTAAGGRPIRIIDPDPDVNRADIVAVVTKALKDYPTLLGVIGPYSDTRLAALLSSPVIQSSGLMLLGPFTGSSAVRAWNENVYFMRAEPRAELLAIVKHVANTIRGRRTAFMYLTGVDFGEREYEDIVALMTPLGLEPPALYSAPHSMTDFAVDMTAFDAMANTYPHVIILWGMPGRQVAEFLRVALTDPRTSSAYIMTCFPLQKIAFQVYYDLAMAEKLTPVDGQLMSSATSFPLTQPNTTHIPAFRAEMGKYMEQTGRVDESLWADEAKAVREYGSGGHEPPSSDSAADVRRFFNEHPNAANLMLTGWLTGKVITLTLVQARWMQSSKMYRSGLFEQMRYIIGGDYVLGDYGAPCNPVAAFLGAVCYCNQGGRAAIVSKLDSATWNTIEESGFNYAQNDCYSTHTSLPRPLHFLTLVFTDDAALTSTALSFRNALAAFLKIVRFETRPLTFSYLNVQRTTAQALLDHQLLNYTADVVAGAITKGMRVDGYLVPAPVYPRPHLVEPMRNYVYLMPTLEQQMFLLYENLATLRRVTSIGSGVRVVLHGYADDEASSITAVLYKSAATFNYNNPSVVMVPSTKTVGSALVRRQINFVLAVTAADVADVVDFLIADKSAIVVMVFDDLALHYTALVTALSSTPASVQARVITFTNLPLWSDTSEKIYLDFPLMQVFHLAMKVPSNYTPSSLMNIVTVLFAMELASMTPEPNSAAMVDALYRNGVMFTEGMAFGRFNWGCKVTSSGRVCLQHNYGAQSIVMLSVQRMLDPRVPPLTAPMTPSLVYRPRVASSALTPAERNGIIAGVVLLVVASIAAVGLLLYCCMDNRDNDAAPKDDDEPVTLVFTDIESSTALWAVLPQLMADAIVAHHRVIRQLIVKHGCYEVKTVGDSFMIACKSAHSAVRLACEIQTKLLGHDWGTVSIDAAYREFELARADADDDYVPPTARLSEEEYAAVWCGLRVRVGVHTGLCDIRYDEVTKGYDYYGDTPNMAARTEAIANGGQVVATETAWWALSNEERAGAAHTAMGRQGLRGVPFAVEMFQVDAVPGRRHAALRTEIEAILPDETATETASSAAGALLSSVGTMSGPAAGIALVLTSCFAPYPVAQRVRELQPLLSKWGVGAPPRSRAVSEEDYCQGLMNRLALRIATVSQARQRMGKGGAVVAGDMPDVDAGGALNPLVGGGGCGAGGAAPRPSGMTAPPRSEEPSAMRESRLFRRTPLGVLPASRAPASKKESCSASTIGWRDDVMPFTGPASRRASEERNARRASGSMSDEVIVVRMPRGLGWPRHPNMVEPCSGHAGGEARLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RGU1</accession>
    <name>A0A088RGU1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">nicotinamidase</fullName>
            <ecNumber evidence="6">3.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Nicotinamide deamidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_010460</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; nicotinate biosynthesis; nicotinate from nicotinamide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.19" evidence="6"/>
    <dbReference type="EMBL" id="CP009370">
        <property type="protein sequence ID" value="AIN95147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696689.1">
        <property type="nucleotide sequence ID" value="XM_010698387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RGU1"/>
    <dbReference type="GeneID" id="22571775"/>
    <dbReference type="KEGG" id="lpan:LPMP_010460"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_010009200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_010460"/>
    <dbReference type="eggNOG" id="KOG4003">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1739143at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008936">
        <property type="term" value="F:nicotinamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019363">
        <property type="term" value="P:pyridine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01011">
        <property type="entry name" value="nicotinamidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052347">
        <property type="entry name" value="Isochorismatase_Nicotinamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080:SF2">
        <property type="entry name" value="LD05707P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080">
        <property type="entry name" value="PYRAZINAMIDASE/NICOTINAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="8">
        <location>
            <begin position="31"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN95147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="222" mass="23203" checksum="B3758D5D063B4442" modified="2014-11-26" version="1">MACTATVAATATPPPPSVSMPCVSVSNSTDVLIIADMQADFLVPGAPLLVKRGESLLAGINAVSASLPFRYQVATQDWHPANHCSFIAQGGPWPQHCVQGSAGAQLHAGLRTERVNTIIRKGVSQEVDSYSAFLDDNGSPTGLAGLLHSIGARRVFVCGVAYDFCVFFTAMDACKSGFKVVLLENLTAAVDDAAWPARTEELKKAGVVLLQSSALVADGSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHU6</accession>
    <name>A0A088RHU6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA replication licensing factor MCM8, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_050320</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="AIN95473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703795.1">
        <property type="nucleotide sequence ID" value="XM_010705493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHU6"/>
    <dbReference type="GeneID" id="22572110"/>
    <dbReference type="KEGG" id="lpan:LPMP_050320"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_050007900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_050320"/>
    <dbReference type="eggNOG" id="KOG0480">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="422555at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000026">
        <property type="entry name" value="DNA replication licensing factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003030">
        <property type="entry name" value="Putative DNA replication licensing factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF47">
        <property type="entry name" value="DNA HELICASE MCM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="6">
        <location>
            <begin position="534"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="318"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN95473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="996" mass="105156" checksum="3A2FB55DFD52AFA8" modified="2014-11-26" version="1">MQGKRGGDGSGRTTGATPTEPPAAAAKAHAWMDALWEMHCGTPLAGAVRYTDSIVETMWGVFQPLLSKLDVYPLAIPEVQPEMVTASTAATVALTDFVVLRLLDPAAPGRRCHRHRGGDGRDVAEDPTNEFGNVLTPVMRTALLEQPCIVLALVEFFAAVWLYQHEARQLSSSMNAQGDRQCQSDGGTHPTTSSAVVPAASRAPALRRVYASVSGDMRHATSFDHIGAALLGRVLTIKGTVVRMSPTRISCVRMAYRCGHCGVVKEQTTEDGVLTYPGPCASARCRGYKWTPLTDQAVCEEVQLLRLQEHTTFFDVSSSLTSPSGGSAATQQHGEGNGSQCMGNGDMHVMIEVELRPPWLDAVTVGDCVCVCGVLETRRGEGRQSGGMQQVCLRARSVRSLRSQGTFSSSSSLSCIAALQHRQRGGVHLAATGGHRDGPWRPAHGVGAATFADGAGTGDCLHGDGEREAEDELILGTAAQLGRVRPTVIAAEATTSAIPTLLSGARASAFSSGLDSWSAEEAGRFYEVARHPQWFARLTASVAPSIFGMELVKQALLLSIVGGNRDKNGGETRSSIHVLLVGDPGLGKSQLLRAACAVAPRSAFVCAHTSSSCGLTMTLTRDPVSGETTFEAGAVVHGDGGITCLDEIDKGVQEHKALLEVMEQETVSLAKAGMIFSMPVRTSILAAGNPIGGCFDVSKSLAANVNLSPALLSRFDIIACLRNSHGTNGKAQQALTEHVLQWHRCGPAGGDDGDGQGRGHNALARSGGAGPLPLPLVQRFLLFCRSQCQPTLCREACDVLQAHYLAQRQHLPEPQYGFTHGVTDSRAGGGGEAGRFSDCGSVSGSFSTPAMGLEATVTPRYLQALIRVAEARAKLELRHVVTREDAEYAVQLLQSCLRSFDGLAAPGSAAVGAAAGSAEAGAGKKLAKLNLREAVLQRLKLAIVEEKNGVNLFTEQAILDVCESVGCRSATAMLRQLNEYGFLLQKGSSKYCLCGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHY6</accession>
    <name>A0A088RHY6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_060160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703899.1">
        <property type="nucleotide sequence ID" value="XM_010705597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHY6"/>
    <dbReference type="GeneID" id="22572222"/>
    <dbReference type="KEGG" id="lpan:LPMP_060160"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060006900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_060160"/>
    <dbReference type="eggNOG" id="KOG4280">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF29">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="7">
        <location>
            <begin position="5"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="606"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="495"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="606"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="159"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN95577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="662" mass="70217" checksum="47BF8F008E510111" modified="2014-11-26" version="1">MPTTHVKAAVRVRPLVEMEMAPTPSASSPPPPPGDSHSHDTGGTKLSYSEVIRVVTAAGRLTRPMTSPYMLEVLRPPTVRIGCGRSVQRHSMPTRQSRLHNPGNGGGGGEGRCEVATVYTFDYCAGPSTTQEEFFDMLEMPALCEAALAGEVVTVLCFGQTGSGKTYSLSGRTLPAPASAGPVSDAPTPLVAEDGLQYQAVYYIARRLKELRRSSRKLKSRRQGSDGASVGASASSATVVTSKCSYVELYQESLYDLLQPDGGDGLQCRWSAAASSFFVEGSLMVECRGREDFLLVLREGQRNRQRGSHALNLDSSRSHVVFTVFFEARDEAAAATSSGDIGSDGAPSSPLGASAPLCTTRYGRLVFVDLAGSERLKKTLSTSTAETKSINKSLFTLGRVLELLSAPPPAPSTKVLTSASSDAVTPSKALAPPPPFIPYRSSVLTQLLMHSLDGHGRTVMVACVSPSALHLEESLRTLHYAERVRHIRAVPVVHVDTATQERMALEEKAQALRKENALLRRALGLTGVGSLEAGQVEARLEELHRAWAAGQLAALPYEAPSQGAAAPSWPSSAPQQGQVVRACPSRPAVPFATSGTIVAAGPTDLRASTPQTVVMSSTESEANDESPSGTDDVAPPSHNPHAAAVNILDLLESLPDTRLMYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIA3</accession>
    <name>A0A088RIA3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2HC/C3H-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_050830</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="AIN95525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703847.1">
        <property type="nucleotide sequence ID" value="XM_010705545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIA3"/>
    <dbReference type="GeneID" id="22572161"/>
    <dbReference type="KEGG" id="lpan:LPMP_050830"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_050013000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_050830"/>
    <dbReference type="eggNOG" id="KOG3940">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10255185at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026319">
        <property type="entry name" value="ZC2HC1A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049899">
        <property type="entry name" value="Znf_C2HC_C3H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13555">
        <property type="entry name" value="C2H2 ZINC FINGER CGI-62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13555:SF36">
        <property type="entry name" value="ZINC FINGER C2HC DOMAIN-CONTAINING PROTEIN 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13913">
        <property type="entry name" value="zf-C2HC_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52027">
        <property type="entry name" value="ZF_C2HC_C3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2HC/C3H-type" evidence="7">
        <location>
            <begin position="630"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="22"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="219"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="323"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="553"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="603"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="240"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="333"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="359"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="555"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN95525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="668" mass="69020" checksum="E3CF94DC8979AE66" modified="2014-11-26" version="1">MPAGAKSRTPATDFVYDYAAKRQAQMERARQLREDRLQQQQQCQSPFTQNSGDDGVGNPYAASPKYTTASSAKGNGAAAVVGADMKPPPPNVPRLRHPTSGHSSVDSGAPPGKGEDGPVLYVKERDFKQATQAGIITPDQARQLWAMLSNQIIRVCSPSAHANAVSVSSLLALSRNSYNSSGRAAGGLQSAEGSEFGASISLESLRTSIAYFKREQQRLLQQQGGGGSTTGAPSQGRHPLSSSPPALNSTAGQPASQSRGLPSRQSQYEANIKNNHYQDDDGASKDEQRALATPLALRSAGGGGAGRGGRPAWNADVEVHHEDDYDDDRNRHAPSSPSAISSGGAALKKPRTGKTNAVRSAPKGAAAPSPSAARAGVGGVRGTSSQAGAGQADGGYGNDSERNCSNVYMPPQSSPPVSRSAKAGGTGAAPRRPPATRATAPPPSSGAPINLDDVPVGGGGGGGMNDWANAYPPGMAPPVLAGGNDTIAAEAAAAAQEPMQKCRICSRSFRISVVIRHEALCRKQASKPRNVFDMREQRLDGVEGIKEVQRAATRAGGGGGGGRGGGRGGGGDVAAAAAAAKGKLPKWKIQHEQFQAAMRAVRRQQEGGGGGFGSGQMAPPPPPIPDEYDDRVLCPHCGRKFAQEVAARHIPKCATTIAKPKGIRPIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIW5</accession>
    <name>A0A088RIW5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_070390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009376">
        <property type="protein sequence ID" value="AIN95725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704047.1">
        <property type="nucleotide sequence ID" value="XM_010705745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIW5"/>
    <dbReference type="GeneID" id="22572374"/>
    <dbReference type="KEGG" id="lpan:LPMP_070390"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_070009000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_070390"/>
    <dbReference type="eggNOG" id="ENOG502QSAT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267149at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN95725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="648" mass="67102" checksum="104F0FD545740827" modified="2014-11-26" version="1">MSMQLFSFGHPCEHQLHRACIGGSNCPLNGYPDTWCCSFIKGKINFKRDRPCEGPRCYWDYVHPSQSQFDEVTQVLEQSRPIAARLDEASDTDLLSFSISNPHIIDTVQCALHMMRHPPSACARRVGQLLAYATLLAGDQDVFVQLLKTMKKPVDGYILGAYAFLTQGKGSSVGGAGKGGGAFGSGAKKQTKKKDAKEDITATLVNIMVELMNAALSLGGQLVDRVDQHVLQAMLIQALATYPKSDKRHQDMLEKAIAKFGHRRLEEEEAAAVKREAAKREAVTTAGISANVAAPLSAVKQEPSEPPAATFSAAAAGAGGAASANAGVNYSPELSTGEETTTLTASRVPAAATPIAEAAAAAAPAAPASHTAAAAAGSARIASRSSAAAAAVLPAVGGDAVAMTIGIGTTATVQLAGTATPKATVSSVPGTPSRAASSTPLLTTATTSTAGAAPLPATFSTAIHVQQHVALSVPASMSAGQGTTAGVPGTQTMPAAAAPAVSLPAPARTAVVGISKLYPYLAGRAADMSEQLPGVSPIHDPQSHSSRLFICGGQLTVEPLVWNYAPLGDAAANRRFDTPTREYMRIKEKERQRRREARAAHLAANAAGGFPSTSEGFKAAFSFNLDREDSWMGDGLDGDSSSSDVSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJ46</accession>
    <name>A0A088RJ46_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATP-dependent hsl protease ATP-binding subunit hslU, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">HSLU</name>
        <name evidence="8" type="ORF">LPMP_090220</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpX chaperone family. HslU subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN95938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704260.1">
        <property type="nucleotide sequence ID" value="XM_010705958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJ46"/>
    <dbReference type="GeneID" id="22572592"/>
    <dbReference type="KEGG" id="lpan:LPMP_090220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090007200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_090220"/>
    <dbReference type="eggNOG" id="KOG0745">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1721884at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009376">
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        <property type="entry name" value="ATP-DEPENDENT PROTEASE ATPASE SUBUNIT HSLU2"/>
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    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
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            <begin position="83"/>
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            <begin position="395"/>
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            <begin position="186"/>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
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            <dbReference type="SMART" id="SM00382"/>
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            <dbReference type="SMART" id="SM01086"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="503" mass="55553" checksum="384A782F8F43FF7A" modified="2014-11-26" version="1">MFRLLSRPLRCVAAAASTPSPDVVQITKEKANKLDDLSPRAITKILDAYIVGQDAGKRAVAIALRNRWRRRQLSDAELRKEVVPKNMLLIGPTGVGKTEISRRMARITDAPFIKVEATKYTEVGFKGKDVESIIEDLYTNAKLKARRALEAERHAEALNMALDTVYSAWSVSQRMRGMDRSLLGAGKAEEGTSAAADDSASESEESPQQSQPHTFEYFREHYQEEPIKNDMVTIDITAPQAVTKPPKEGGIDLQSVGMLLGLGGEPKRLKMSVTKRVADAVPLATQEALDKLIDEASVNTLARALAEEEGVIFVDEIDKVVAEPSSANADVSSTGVQQDLLPLIEGSNVTMKDGSVIATDNILFICSGAFHVVKTSDMIAELQGRLPVRVELQALTENDFRRILTEPKFNLLRQQEEMMKTEKIEVVFTEDGVNELAKVTCAVNAQGQNIGARRLNTILERVMDPYSFNCEDYEGKKVEINAKVVHEATERLQKNVNLAKYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJP7</accession>
    <name>A0A088RJP7_LEIPA</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">LPMP_101180</name>
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        <name type="scientific">Leishmania panamensis</name>
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            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_010698538.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A088RJP7"/>
    <dbReference type="GeneID" id="22572855"/>
    <dbReference type="KEGG" id="lpan:LPMP_101180"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100019000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_101180"/>
    <dbReference type="eggNOG" id="ENOG502SK5V">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome 10"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
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    </dbReference>
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        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
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        <property type="entry name" value="MPT-1-like_LmxM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37036">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37036:SF2">
        <property type="entry name" value="DUF1861 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08950">
        <property type="entry name" value="DUF1861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN96187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="328" mass="37036" checksum="FAF1421EBBB8241E" modified="2014-11-26" version="1">MGSPAPYSAPKEPRECMMVAKRKEFERTKVVQEATFITFKGLGTHDVYNCCVPFRINGVCHVFGRTERRNEWVRSFVRLFRQTGHDEYTLVEHAMQWQLEDPFIVKVRGEMLFGGVRVTKDHGKVSGYMCDFYRGTIDDLHYFTSGPQNMKDIRLVELADGRIGIFSHHKTHTTCTTGFITIDSLDNLCSQIIDAAKPIDHTLFGDAWGGVNQPYLLSTGKIGCISHHGYLDKDVNGEVINVYCITSFVYDPLTNKCFEYKILGTKSCFPECPAKAPKLMDCAFASGIVMRDDGKCDLYSGVGDTRQGRMVIEYPFEGYGSIVDNVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RK50</accession>
    <name>A0A088RK50_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_100850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
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            <taxon>Discoba</taxon>
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            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696808.1">
        <property type="nucleotide sequence ID" value="XM_010698506.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22572822"/>
    <dbReference type="KEGG" id="lpan:LPMP_100850"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100015000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_100850"/>
    <dbReference type="eggNOG" id="ENOG502SG73">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273843at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34993">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34993:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="515"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="549"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="576"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1807"/>
            <end position="1831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="659"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="759"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="935"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1162"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1347"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1442"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1524"/>
            <end position="1643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1665"/>
            <end position="1711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="943"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="967"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1162"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1173"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1357"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1444"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1524"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1537"/>
            <end position="1550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1950" mass="213789" checksum="F28E007D2A5FBDD1" modified="2014-11-26" version="1">MFFDVVDMTTAYIQYITLLLNLSPESLPSFYREPFVVIRYAVFDPYRKVEEVQRYNNPLRVDLPDWLPLDIRLQYVCVAVIGPLALSTVGLLLVYGKPAYLWFVCLLSTLFMFLFGFIVLANMADLTFPGSSLPPKSTLSSLGGVGLPLFVLLLAVGLVSMGRARLRHLRRDAVELEKLIDEERQRRESLPITQQLVDRQGIDLVAVAAERVHAKRREYRITHLDAEDVLWQGAFALLLLMGSLVLLGAIPIPAMHYMQQSIVFKVLGSITAVLFAFATVWWTMSLFTKGRQYLYVCSTAFDLRALSLIMVVASLLYISVVTHFISIVYCMPLTCEAGSRMPHSASLFPPLSYATDGNNISDDLSVARCLSCDFHSYPQKCSTALQENLCATSHQQSRLVYDTRVPCDSMDGFYIASGILVFTFYILFLPYLQFYVAQYGVRMLQDAYPLEQRYHDVFTPEELYLQKVLFSDNSAAFAYRAYKPQFRFYRLSFLLQKIILGIVGCVMQRGQQRRIAWVGMLFFLVVPLIALSCAVYLQPFSRPTEAIYFPSLQAMVSVCSLVFLAAWHFGSAAVPLAVWIILPLALVGVPAITLGVGTVLSLREERRWSDMLEKRLAQGVTVAYARPGASVQQAQSSNPPQPKPRVGLVAGIMEAATRNSDAGVGDSDTKQRPSRETRDAKKPAEDSDGEELWQCGPGDGSRSLITFSDMPLASAAAAGIAAATDARVAALPQHDNPDSDLLSRRSAAMTLSPAFLTALHQKPGAEKSPSRRLPASSSPMEYARCPSLSRDKTTLAPTFLLSTPTTLSTHTSIRTQSARTRQGLSALLQARTWWGSLKAFSLIAVETVAAPFLLFRHRNQLHCHDVGRDDKRGDEMVSIRGSDWGASMPAAVGPCAEPKGQQQRRSVIVGKPSLIMSLASLFQCAGRSSAANPAVVNAGHRGSSASSDQPTGCASEKPRRRRRASLQPHQQSATHSTRAAREDAGSGAAGALRDSLPALAPPAVANTAPAWPASGRQRRRHSASFLVSSFCAQLVQLWPGQPPRAVDNRVGVTAGEYAREATVVFVPSLFFAPHTPATWRFAKVLSRIHHPGGHRRWSSKGDANAARAPHSAAMARPFSSSLTGALVDVPLPRKRTSLGEEGSEAYSLPPWVPIWTHLSPSDPVPTVSPSLPRHLDDRPSGGTANHDDDSARSSGCRVVPSRLQQVIRKMMRCLSCSLVRGPRATDRSSGGNGGVGEVLSFAEVYARRQACARDVTQSGLERLCTAQELQRHRHKRFRKAFWGNPTDAMFGVVDVPGSMPPWSLFCNVSLPPVTPTALPTTAQRQPQQRTMASLQNQYYAQLVEEQQDADMPKKSGGTISNRSASLGTDRGAGAAAVRYRKRGVTAESNSPLRSMTCASLSAVMNLNFSLPVHPVRAAARERQAAAVLLQQERSQGTVPVSLDTEMREPDPGKKRSGYKGSSGELNVEDVHYDGCRNGVSVDLDDSLLSSEAGCGQNARLAGTLHWLEKWGPVLTELLYETAKDDEKHVATEKRRTSGTTDSSASSDTRGNGSSPSTDAAARVRPDAWDTESQQQRRSKWARKGWLMRLLPSNWGSTSSKSARPRGGDKAGHQKRSFNSDDQVSRRSGAHHKPPPPPSLSSMRRQPSMLLSLMTGNVYCQTSKSGTLSEASVPGSATRAPQAAVPEIVPGNSRRSSSPFSVFGANSSSSGEGAAWPYRQYPTTLHTPNGDWLNKAEPAVVTKRLNPASQPHSNSAIPTDPLIQQLRSLYLLRERLKESYWEHREQLKAVQSYIDYEINEAVRRVLSFLFMVLGVVATIALVLALCGMLHTLDWAFINGVRRSNGALRYELAGYSSWDNFTHNCCCMAATDAAARYPYYALDVENWVCANGITKERVRRDGYDDLITDGYAVRALCGMEFKNNCMVVVDQGVATLKGCDAAVVSEKAMQRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RK83</accession>
    <name>A0A088RK83_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_111340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696981.1">
        <property type="nucleotide sequence ID" value="XM_010698679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RK83"/>
    <dbReference type="GeneID" id="22572999"/>
    <dbReference type="KEGG" id="lpan:LPMP_111340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_110018000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_111340"/>
    <dbReference type="eggNOG" id="ENOG502SB80">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10255964at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="3">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN96328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="386" mass="43711" checksum="54EC455149CFAB4A" modified="2014-11-26" version="1">MVQPEQHIVYAIHEYAIPGSRFLPLKAGDVMHVEEADESGWWLGTNLRGQKGIFPSTYTLPYVFPPPMEDMMRDMRLIMLGRCFGVDVASGVPLPLLQCMDAEVCDAQMPTPPPYFSYKQVHKRLLDREAARTRVMKLLSQLMETCTCVEEERAKIAQGLATQEQQVADRQAALSEKFAALEVSLCALTVRKSACLQDGIVPTSAWYEQFNIVSVSGTSSSDSLSYERAWRSTLRDVKEVVRGQEEELTCLSTSCAQQEDAFVRATSSLQERVQWRDGSVARMLAYWAYKAQAVKTAYRDAKVMHDATETTLHLEASQLIHLLEEGRERYIQAKELFRQFRRQAEEISAVLQRKDALDSLSREIAEVDAAIATHEQWQRHDPVALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKI1</accession>
    <name>A0A088RKI1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Calmodulin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_131040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697185.1">
        <property type="nucleotide sequence ID" value="XM_010698883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKI1"/>
    <dbReference type="GeneID" id="22573214"/>
    <dbReference type="KEGG" id="lpan:LPMP_131040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130015000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_131040"/>
    <dbReference type="eggNOG" id="KOG0027">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000003">
        <property type="entry name" value="Calmodulin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050403">
        <property type="entry name" value="Myosin_RLC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23049">
        <property type="entry name" value="MYOSIN REGULATORY LIGHT CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="7"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN96532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="217" mass="23385" checksum="A2B7ED39E54EB9BE" modified="2014-11-26" version="1">MESLSESELKELKEIFDLVDSDHSGVISLQELRKLMITLHLKPSEQELEEVFEETCSLPSTTNASASSPSSASSLPLQPSPIAAAVTHDGSVASTSSNEIRATARVAGRHGKPGSFPSDEAAVAAAARTVTFPQFAAMMARRMQSDYTAKQLRNAFQLFESPDMPEGFVSAGVLAHALATYGSQKLEKEEIDRLMAAIDPNNTGRVNYYEFVDTVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKJ2</accession>
    <name>A0A088RKJ2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leucine-rich repeat protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_120170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009381">
        <property type="protein sequence ID" value="AIN96345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696998.1">
        <property type="nucleotide sequence ID" value="XM_010698696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKJ2"/>
    <dbReference type="GeneID" id="22573023"/>
    <dbReference type="KEGG" id="lpan:LPMP_120170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_120006500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_120170"/>
    <dbReference type="eggNOG" id="ENOG502SED8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1517790at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="508"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="805"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="894"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1133"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1200"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="524"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="538"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="571"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="896"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1138"/>
            <end position="1147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN96345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1243" mass="130887" checksum="FBCC203B39C4715C" modified="2014-11-26" version="1">METQSAAKGASRRNEVEKGAVPQAEGGMIVSAAVPSALRSAISKRGGFTHNSSVDRSLAGEPNSTTALSSSSSASARLYKDPYAADLGPRESLKASPHTRASKASYGSPASSVKREWKTVAAAMTQSPPSPSVTAPLLGNSAAAASSAACSTGESPTGSSVCSGAEFNRAHKNQTSIRCPALRSNTDAFDESPAAVAASRTSNSPTAVLAEAVEVLCVELPEVSLSQTSRIASAAGGGRLEVRMRGLVALPCLHVPASSTPPSLDEKEASATSSSAHGSGDVVAGRLHAVSFRQNAITSLVVQSARSTSSPKVSPITPRSSPLRCYAHVSSLDLTHNALASIAGIDALRCLRSLRLGFNRLTSLAPLWASPYVAELDVLDVSSNALAELLSADDVHALKKHHIRIVTHPTQAHSTACAHRNNSSSGQKYMQLRVLYASNNQICEVPSAIYSFTQLADLRLNNNVINRVPDGFPARVCLPLLTRVELSMNGLPSAVVEAVAARVEGAHRFRGGSGPSAEAKTAAFSPSASRTGNSVSSEEMRKGTERCTERSRDHHLLRPAGGEEKARAPADEGTGAAASARASAPFKRKAAGSLPPTAPVITTASAQEAKHQDAVQCIAENVYSVDLNVWAAAVRRRLEELLRRSCDSDASGALSATPTCSMYELLVSLSDILSGNSCGGGATTLPRYRRRLTTTARTIASLLPCLPSCFLVYYEETQVRCPPLLLLTGVTASMAADQSELLLYEVLALHIVQNCLCMVRGATGGVSQPYARFTPSSLALHSPELSSQQACRAENSSASALCTEAPAANRASGSEPPPRRPSNPRTSRQLNFAVPLQVIHVIACPEAAVTTHNSTSALWAYLTWRQRWEAAVSRRRLPSKSFYVCELGKQPAGAHASQSLSSANQPFTAGENCNGTHETPNPAEPRSLYPFTVNTPIPRVLEWRRLNEYRPASYCAVPPAWDLLYDLLLRSSLPESTAPSQPRALAMPPPLIGVGSRVHHPRGIPVSLACVLLRAIEYPNCTGAPITFASPISPLLRWPTPGTGGSAARGAHSGTSTTTAPYAPCEDVIRSALQWRYYSQQLCNRVESEVNSVAAEQVTVCNMPLYSAEEVLQSQKKAVAALSSLGPQYTRLRGLQRRQNDVSEKPLESAAISKEAASNLPLGRSASTKPRSQALRSTSSAVTSYFAGPCASEAITTPDTTAWSHESEAIDTPAVPVGADRGSTPTAGADAAGGKADELGGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RL00</accession>
    <name>A0A088RL00_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_080500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="AIN95859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704181.1">
        <property type="nucleotide sequence ID" value="XM_010705879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RL00"/>
    <dbReference type="GeneID" id="22572512"/>
    <dbReference type="KEGG" id="lpan:LPMP_080500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000015300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_080500"/>
    <dbReference type="eggNOG" id="ENOG502SH7X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266650at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="398" mass="41623" checksum="5EC9D1A595CEAF9F" modified="2014-11-26" version="1">MLQRFSNVSVRQHARETSPSHLDSTPPPSPSRTFDGHRDADPSAYISLAQRGGQTAGSLQHAPVFALPANVCNDTAGAPPPAPPSVSSQRARNFSPALLSQLLLAEAARADATAAVQQSGHNNFEGVSYGSAAPFCVPTSMQQSQRPPTTTTTVATEWRHRRRDSDATSLYESLRESPSSLPQSPPLLSMDYLTVCIGVVPLPSSGAPCGTAASCKRNLWWPWRCTTLTVNSTPATDDVGEAASDRASHSARAYSSVVEVSWPTPLHDPTVSMHQLRPRRLYTSGQQHTATSAVGDSSTLTTSAHLTDVTRPAPAGSVVSTDPSFSTGPTMEVLGWSGVFAAVPLVLPGAQLACGPDAPGLAMKVGRDAHPRRGGCDGSCQSKDLVCAGAASISVILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RL08</accession>
    <name>A0A088RL08_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mitochondrial DNA polymerase I protein C, putative</fullName>
            <ecNumber evidence="3">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_140890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.7" evidence="3"/>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697320.1">
        <property type="nucleotide sequence ID" value="XM_010699018.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22573356"/>
    <dbReference type="KEGG" id="lpan:LPMP_140890"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140014100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_140890"/>
    <dbReference type="eggNOG" id="KOG0950">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2320933at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002298">
        <property type="entry name" value="DNA_polymerase_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133">
        <property type="entry name" value="DNA POLYMERASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133:SF23">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00868">
        <property type="entry name" value="DNAPOLI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family A palm" evidence="2">
        <location>
            <begin position="1331"/>
            <end position="1574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1048"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1196"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1200"/>
            <end position="1210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1621" mass="178337" checksum="058FA2F4EBCD4A34" modified="2014-11-26" version="1">MDPVSRPQKKRARASRSSSTVASAEPSPPVAQAPLDTPCQYSGSTVDEVDENDVRSNEDAGAQHHGDLYGDSTELAVGEASGYGGSDHHDSTVVDDGDIADDAVTGTNLGEAEQVERAAEVREETDYSAVDGEIASALPCIGNLLDFESPLNLRLATLTRQHGKAFRAIAVYLPDTRTTMNFDITFEDIASGARLVCKLDEIKSRYVEWISLFCASFIAVFVPTLQSPSVVLLQNAIGSSRPARPPPPAGSYHPQLNEDPDHLFFSYTKLREVISHKKKDKALNPKLLTMAVLNAYAEEWKNFISAPLSCAPQAFLLAAFNFQSHSGDINAGAMLNKELLQAQLAAAADAIVLYSSTNGSQATRRRTGAVATSLSATSTGLLRNESDRWGLIFVSAPARTAVGTAAIPPMQDLLTGQFVQPLSLSERHLIYIIGTGSAAESFARFPLARKGNCAFSILLQDVESQLGLERPHRLNLTSMLTQALDSFSRITWMGLMKEENGEPHMPHPSSAFYRLQRRSVQREIMPSFLEPVFAPGPRFMGGGAGGRTVDSMGRPIRGGTPDVAVGRGGTLARDLRATAQASRLLEEHIQVIYNSQERLSREKALQEAMRSRVAYFMHVTSASVTAARRADNPFSARNGMIDVLGQLWTSLSLMNPPTVRHWQASIEDKTGEVKKFVDPEVVLPDTLPIGPPEAPNPKDRAENAILIGWDIKRILLFLRRSVRLRTFLYNGGKVWCAQYAQYLLKGFNNLHLATMERTLLQYHDGPLKGSMQPLAKLKLIYEMQLEVAVSTRQMSSVQHRMDGLLASMEMELQGLQLAPQSQVTYFANTLRLDHERLEKVLHQKIMDFTQSMDDDVRQRINFRSPQDISTIIYGGGLCRHLGSRFIPVKPTRYPVTSLFPHAVCYVTGTNVPDAYMQVDTLLGGNSGVGSGGQNSGSVITMNDAQRSLQTIQQLCKRCSIDALIQQTAVVVVLCKVKIGGWLEQISLYCPAATGPETREINLRVAVDDVIPVAERPDVVTVTQLKECIAAYEPLKQLLAASSAASTGASRAPTARKPSGKKTRQGGKVGGDGEAAADLRNILILTNCTHDKLETLVDTGVLEAIKKAVFDGHTDGGGPASLERVCFADVNKAFPPPPQGADSFESDFSELTSSNVITFSARCTWEVHAKELVSLGGVEGAVKSIVSQCASVLGTPRDAFRSSQPTPSSAPQGLHGQEQASTAGMLWMVTPEKLHPLLRRFLRGKSASSGADAMERVTTLLSPYKTVDLSFFSALQQLRFTEKKLQLFEEGCLFRAVLPECHDRVHGELCHCVTATGRLSSQSPNLQNIPKEEDLRRLIVSRFGAQGMMIEADYSQLEVVVLAALCRDPRMMQELRDNVDFHCLRVSLMTKEPYEDVVRKAKVKKDPQYIQLRQQAKVFSFQRQYGAGISTISTTTGLTEQEVDRLIVAEEHHYKELSKYYSLVTRCVESGADRLLRLRTLDTSCWNTNIRRVVMLTEPMYYFVVPTGSKFDFTRDRKSVPRLKNYPVQGLAGEIVQIMCGAIVREFYQKRNYGEKAFLVNTVHDCVWVDAHKSVADEVRADLARIMGHTQETIATLWPDMKLDVPFKVEIHSGSSLGELSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLC6</accession>
    <name>A0A088RLC6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin-ribosomal protein eL40 fusion protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_141250</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697356.1">
        <property type="nucleotide sequence ID" value="XM_010699054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLC6"/>
    <dbReference type="GeneID" id="22573392"/>
    <dbReference type="KEGG" id="lpan:LPMP_141250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140018100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_141250"/>
    <dbReference type="eggNOG" id="KOG0004">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="246002at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000285">
        <property type="entry name" value="Putative ubiquitin/ribosomal protein S27a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002906">
        <property type="entry name" value="Ribosomal_eS31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038582">
        <property type="entry name" value="Ribosomal_eS31_euk-type_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01599">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01402">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN96703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="152" mass="16937" checksum="92F51E5D14859879" modified="2014-11-26" version="1">MQIFIKNAAGRTVVVRVSAEDTVASLKVQANVTAGNLFFAGMCLAEEETLAAYGLSQGSTVDVVVPVEGGKGKKKKKRIFTKPKKPTHRHKLEKMRALKYFKVTENDDGSYKVERMRQDCPHPQCGAGVYMAQHKDRQYCGKCHLTYRAEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLP8</accession>
    <name>A0A088RLP8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ERAD-associated E3 ubiquitin-protein ligase HRD1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LPMP_151360</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697511.1">
        <property type="nucleotide sequence ID" value="XM_010699209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLP8"/>
    <dbReference type="GeneID" id="22573556"/>
    <dbReference type="KEGG" id="lpan:LPMP_151360"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150019100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_151360"/>
    <dbReference type="eggNOG" id="KOG0802">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="263722at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000703">
        <property type="entry name" value="ERAD-associated E3 ubiquitin-protein ligase HRD1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057992">
        <property type="entry name" value="TPR_SYVN1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF184">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SYNOVIOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25563">
        <property type="entry name" value="TPR_SYVN1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01197">
        <property type="entry name" value="FANCL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="289"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="341"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="423"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="426"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIN96858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="491" mass="54463" checksum="8FB786A543BC8745" modified="2014-11-26" version="1">MVARRSVVAYVVASFLTCFLFLADYANTYREFYSAMVALANSSSFRLVIVNTAIAVTVVLWMTLQFCFFGQLNASEETALLTSFTLYMVECIVVPLYMDQPIMSATSLFFLFTLAWRGLHKLASERVTTLSTAQMTWSSATRIPAYLCFAIICDVGLLTWMIKTRPELVDEKASMHYSMILIYMLLLSSSLRSTVHFVSLLVLRGQHTLLSFVADALTSIAESLLFVGVYAYIFYNSALPLLLLRGFVGHVLRIFEKASGLAEFLVLARRVRNNMPDATAEDLARDARCTICYEDMMPEGGTKRLPCGHCYHIDCLERWLEGHSTCPYCRANIMQMRGGNDAAAPQVHEEDAGAAATTDAAANDYSPTGEEAPAQQQPTGTPENMEVEIREAYERYRQQLCSPLSAASGHADAGNHLAVIRAGTGSPRRVSSPVSDSSSTHTKSITAAPVPSKTVDQLKIEAYEKYRKRLRESERELRVALRLAEEVGYAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLQ5</accession>
    <name>A0A088RLQ5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Synaptojanin-like inositol 5'-phosphatase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_141490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697378.1">
        <property type="nucleotide sequence ID" value="XM_010699076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLQ5"/>
    <dbReference type="GeneID" id="22573416"/>
    <dbReference type="KEGG" id="lpan:LPMP_141490"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140020900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_141490"/>
    <dbReference type="eggNOG" id="KOG1888">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46817">
        <property type="entry name" value="PHOSPHOINOSITIDE PHOSPHATASE SAC9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46817:SF1">
        <property type="entry name" value="SAC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="2">
        <location>
            <begin position="189"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="734"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="847" mass="93108" checksum="E9C7E3D1545ED30C" modified="2014-11-26" version="1">MESPRGVQSNGAAASPAGPQVRHRCAIAVKNNVQYLFVVVPKAKPPKIELEPLMFFETPSPAPDPQQTKELYAPMQDKWSVSVVVPLEVNGSGQLQRSIVFPATEFASLADVRQQCGPFTSFQEYPALFGCLRVDRVYVLVATAVTVAVSLPFAGAIYNVEGTAWVPFDLPGVAPVRVSPTDRTRLREFQEHTYGQGYYYSDDVNLMLPFPFTKPESYTPPDMACDWSCHLREPFSVCSLVEACSLLVRGFAGERVCTLKDGVGLHLVLLGRQSDINPGPRYLSRGLNSANGAGNDHYYEYILWKYHGADTVTFTRHSILRGTVPVHWTTQMSMTLSEPAMIFSSDKAEVLRGSAAYFNRTFQNLKHVMLLDTNGRSVANPQVRCINLLRLNPQSGEDVLARHFLDAVQMSDAILKQKFPGSSLDLVHVDWLNLIKEYGINAATATFWEASMGFLGTASAPEDSMMTVGMIRRTGDVERLITQSRFVRLNCADSLDRTNLGCFFTCLQLSIAMLITQRIPYTSFQDSPPVPGLDASEEVDQEGGYTAAVAPISGTKQAVRKPFMSTWNDARDPRCIPPPIVRALAQLFVNNGDCVAMLYTNSAAMHSNILRGVCGMRMQGHNAVIATQRKFQNVFEDRKKHRCIELLLGRNQGTHFPSLSKVFLLRPVPYMQWSCAVVVVGVPDTVTTGEIEATVRSVWESGVTAQLAARQLPLIESSALCFVITLSETSVKQEQDGPALSIQQDSSGGMPPEGDLEEDAAQEDNAPFQRNERLAIIEFDPNLCIAVDVATLLRQQGFLPLGGSNCILAPYAYPLQRANDSSRMSGAVKNVGSSLKRGLTSLVRGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RM84</accession>
    <name>A0A088RM84_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ABCA4</name>
        <name evidence="1" type="ORF">LPMP_111200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96314.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696967.1">
        <property type="nucleotide sequence ID" value="XM_010698665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RM84"/>
    <dbReference type="GeneID" id="22572985"/>
    <dbReference type="KEGG" id="lpan:LPMP_111200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_110016100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_111200"/>
    <dbReference type="eggNOG" id="KOG0059">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN96314.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1817" mass="200330" checksum="B06E27E648CC6D4D" modified="2026-01-28" version="2">MGRLPSAAAPPESSFSPATGTSDSDVNECSRRNIGVATADVRKDERPCLASAERSSNLSGLSPREGPTSREGGKSNPLQGISAEYVSSCDSKLGLESSYCGYNYTGSCSSTFESGVSLKPCSTAAYHRSSTSVFRPLSDRTTSGVDQLLEMVARSATQLYRRPLGLVLEIVVPLLFIATTIALWGIWGDIPHPEASFVSPPKTTVGMLPAPETIGACWNEKAYADHIGSLPPCSTVSYPYTCDGDMTATPFPPESICRNDTVPFVDMTLAYLTSLVGHLSRVPSLDTIITFQMLAQMQLKPLTELGAMAVSNLHPVMSFNAIIASGKVYIVGQLNFTRKLIEHMNAESSLFSFFNDGNVYASVDEVWSAVPAGSMVWAIVELRSSSAQGLDMVLHMNNSALPSLGTTDDLTYPGGVLNDTAEVYIASGFLTLQQTVTEFYLSYYGLYTTSQAQFLASFPHPEYFRTPLLTRSRELLSFVFGVAFLYSVSQQVKRIVLEKELRIREAMLIMGLRQWAIYVSEFVVQLAIFVPTCVLCVVMLKLTYVTKSDPLILFLIFFLFALTTIPLSGMIAVFFSKSRLASLVTPVIYFILVIPMFAMTNTHGSIVTWLSLLSPTGFTAALNVFLLHESGSGCGAAQMTSSRDSPTLAVVLGMLSADFFIYYALMLYLDAVVPKEWGTPRHPLFFIMNPVRWCFNSKPQRLGGGADGRAEDGVFETSDYSKDCVSFEGIRKEYSRGGRTFVAVNNLYWGMREGEISVLLGHNGAGKTTVLNMMTGMVSADAGDCYIYGSSVRTAKTDVRQQIGYCPQHNILWPELTCRDHLEFFGRIKGLRGWELENAVCRMLYETGLLDKIDQPAKSLSGGMKRRLSLAVAFVGGSRLVFLDEPTAGLDVGARRQTWELLRRMSRARTLLLTTHFMDEADLLGQRIGIMSHGRLKCTGSSLFLKSRLGVGYNIVISVDPELDPAAVDDAVLGTVDGAKPLGRNGCELSYQLPVRSASQFPALLAEIDSVEADGIRGYSLAATTLEEVFLKVSEEDIAGRSEAVSQESVERIWNCEVAPSALWLQFRVSMAKRLWNALRDRKMQCFQIVCPVVCILIAMLLNLVQYRDPQSLTYDYAMFAGKANPVVLTAGCDALWGSEPLPVGYEVNETHFMGAQMLSDYLLDTWYVHNVSRFGGVACNDPEMRGNLSLYVQNIFFLNTSSRHQAAISLATYYDLLAKKSGVEGVYVKHSATLMHKPEPLSGLTFFFMGSLILIPMSFLPSNPVAWVVKERQCGSRHLQNLCGLNFFVYWAANFVFDMAAYFVTMLLCILIFAIFNRQEFIGHDRIGGTLVLFVVYGLTSTVGAYALSFLFKEHSSAQTMVMAVCLVLGFLLNVTVFVLTLREDTTSIADNLRFVFRLIPSYVVGEGIVDLLMFNSIRIIGRAQSVWDMDQLGWPLVYMSVEFPVFWLITLFVDHPAVGQFFDRLRYNPSAEPIIPSGEDSDVEDERDAVYEAAHMGAMTDDIVRVVDLQKRYRNGNVAVKGVTFSIFPGEVFGLLGTNGAGKTTTISMLCQQLLPTGGRAYVCGYDIVEQREEALRCIGYCPQFDATLDLLTVEEQLQLYAGIRGIVRAEWPALVDALCTLCELTMYRQTVTGALSGGNRRKLSVAVALVGGPQVVFLDEPSAGMDPVARRGMWTAIQRAAGHCSVVLTTHHLDEVEALADIVAIMVRGYVRCIGDKVHLKNKFGSAFEVSARLASAKWAKCFESFMKAEFPEAVVVEGADRRFVYQLPRDRGFGDVFQTFQANKERLHVTGYSVSQTSIEQVFLRVSETSKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMK1</accession>
    <name>A0A088RMK1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ethanolamine phosphotransferase, putative</fullName>
            <ecNumber evidence="7">2.7.8.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_180810</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.1" evidence="7"/>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697915.1">
        <property type="nucleotide sequence ID" value="XM_010699613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMK1"/>
    <dbReference type="GeneID" id="22573971"/>
    <dbReference type="KEGG" id="lpan:LPMP_180810"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180011000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_180810"/>
    <dbReference type="eggNOG" id="ENOG502SJTQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="196717at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004307">
        <property type="term" value="F:ethanolaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF68">
        <property type="entry name" value="ETHANOLAMINE PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN97262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="410" mass="45371" checksum="5853C92A640FB33B" modified="2014-11-26" version="1">MPSWISPAAPPEMPTVSAEPSVLAEYLLFPFYDYVVQFYPQSWMPNKVTLVGIFSTVFSSVLLLGSMPAGLQFQPGRMELLPSSLVKDPAIPKVPPLALTEMTPILPFMSPSLMLVLCGSLNLIYCVADNTDGRLARRDKKTSAIGEYLDHGLDCVTSLLSTCCVFLLLASLCNMAISVCLVAFVTVLSHTLHFEANIFIWGNRIATVDEAMLFFGLSMWWPLVCPGVSTTRVPEWIIEGIFGWNSSWATYLRPLRMVELVYIFYSIAQAQTIFRMVSWRWRILCRIHVIFSVLNSLVFLMLMGVHSEYVAAAAPLTSVPGYTLGPFTYPAVWSITVACTSSTIIHIPIIARCARLPVTDPLPLAGIMLVWLIFISCPVAGAILSVVLHVGQMLLNVDFIKKHAQNNNAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMN4</accession>
    <name>A0A088RMN4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mitochondrial carrier protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_181260</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97307.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697960.1">
        <property type="nucleotide sequence ID" value="XM_010699658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMN4"/>
    <dbReference type="GeneID" id="22574016"/>
    <dbReference type="KEGG" id="lpan:LPMP_181260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180015900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_181260"/>
    <dbReference type="eggNOG" id="KOG0759">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="756301at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000139">
        <property type="entry name" value="Mitochondrial carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN97307.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="316" mass="34361" checksum="2E07F6120985C526" modified="2026-01-28" version="2">MSREAASAPKAAAPPLPLWQSLAVSGFAGMFGWCFTHPFEMWKNTVMMAPPGTSQLDSLKVTAKRGFYTGLSSGLMRQMVYTTARLGCYPAFRDGILQCEVALGLKKSADPAGTTVLERALAGASAGVFASFLSSPVEVCLVLQTTNKGKERLSMLQASRMVLKSRGIPGLWSGFGALASRAAMVGVSQVAVHDQVLTMLRSHNVKRPSPLNDNLVINVASVITALFCSLVTMPMEVARVRMSAEAKLGAGVEKKYRNAVQCIGRIFKEEGVLAMYDSYLPYFGRCASQTLICFFMIEYLTRHLRERQLAKANLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMT6</accession>
    <name>A0A088RMT6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">60S ribosomal protein L7, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_180220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697856.1">
        <property type="nucleotide sequence ID" value="XM_010699554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMT6"/>
    <dbReference type="GeneID" id="22573912"/>
    <dbReference type="KEGG" id="lpan:LPMP_180220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180007200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_180220"/>
    <dbReference type="eggNOG" id="KOG3184">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28644at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.15.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF40">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="297" mass="34383" checksum="869A2BD94E541B40" modified="2014-11-26" version="1">MGKNPPKWLPGERVKETILLQRKSVEQLRADRVLRKDKLQERRDRHKKKLDAKRKQRLSTKKFISAQTILKHAQRKEHQGRKFQKIGEKVEGRRRHANMEELKKKLRESPVRLVVRAKGSQIPPEVASAFKKVGLLKIYAARLITLTPRTEKLVEQLTPFSIVGEPDRTQLESLLRTRGALYNEETQTKRLISGNLLLEQALGQYNVLCIEDLVETIATHGEHVEEVLRHIAPFDFHPPRQLFVERHRSVHQKLEIVNKDSFAAYLADQLQLTLNKERKAATVAKKSKRVGVQPKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMZ5</accession>
    <name>A0A088RMZ5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_171370</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697828.1">
        <property type="nucleotide sequence ID" value="XM_010699526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMZ5"/>
    <dbReference type="GeneID" id="22573880"/>
    <dbReference type="KEGG" id="lpan:LPMP_171370"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170020000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_171370"/>
    <dbReference type="eggNOG" id="KOG3991">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18915at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22749">
        <property type="entry name" value="Otubain_C65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.60">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.20">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019400">
        <property type="entry name" value="Peptidase_C65_otubain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042468">
        <property type="entry name" value="Peptidase_C65_otubain_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042467">
        <property type="entry name" value="Peptidase_C65_otubain_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931:SF15">
        <property type="entry name" value="UBIQUITIN THIOESTERASE OTUBAIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931">
        <property type="entry name" value="UBIQUITIN THIOLESTERASE PROTEIN OTUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10275">
        <property type="entry name" value="Peptidase_C65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="OTU" evidence="7">
        <location>
            <begin position="70"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN97175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="267" mass="29951" checksum="2C8F925A78511842" modified="2014-11-26" version="1">MSETVMISASEAQLEAIRKEVAQSPLLSLSLPLDKGSKIVKEMEHDEAYLAQTLSLFGASAVSTKQYDFNSIRYSRRDGNCFYRCAGFRLCELIVERPERAAEYVSLLKSRGKSLSRLFGSFVFDFTDALAEIFNGVADKTIKDVAQIYELFTSSDGAYVVAALRYLSSAYLQEHEAEYEPFVEGLGYGTVRDYCNAEVELVDHESDNVQLAVFAKAFNVCIKVYALDRNAGNNVTEHTFNDEAKSDGDQLVVELLYMPGHYNLLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNC6</accession>
    <name>A0A088RNC6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Superoxide dismutase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_200750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698274.1">
        <property type="nucleotide sequence ID" value="XM_010699972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNC6"/>
    <dbReference type="GeneID" id="22574282"/>
    <dbReference type="KEGG" id="lpan:LPMP_200750"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200011600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_200750"/>
    <dbReference type="eggNOG" id="ENOG502RY08">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272609at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.450.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047002">
        <property type="entry name" value="Tcp10_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42769:SF1">
        <property type="entry name" value="MANGANESE_IRON SUPEROXIDE DISMUTASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42769">
        <property type="entry name" value="SUPEROXIDE DISMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="495" mass="52999" checksum="B62FA90E6A364DA8" modified="2014-11-26" version="1">MLRDCTPLFFMRSEAAAAELRQLLPLLPLTGKRTGVATHSIASLIVSTAYLATTAQSAINHSRDCPVLLKKLPLSLIGKEPSFAARPCVNCVRERVHYVSSVSFCNYFEQKCAEAQHYRERTFSNGAVGDAALPKLLLEAIERSYGSVSAFKDSVALHSTGAMSPGRLWIVYSPSISGSEHGAVSLLNLPASKVPLVYGLWPLALINMTEGRLCEQIACHSGEGGDAVDADTAPSWSHVARAPKVLGALATTAERNHRSGNMVQVRLSAIQSAIAEEALCAMNWQFVETQLSSALAYYSSKERTQAQREHRREKEHVAAVRAMSQLKDSGAVIHATDSVRITSSNSFGASPASGPSLSTTAVAMSSSAKTECNVLGEASLQATAVTAPSAEATAASTTSSPLQVADDTTTGATAAEPRTVQQADGTWEYHYRNGNVTKVFPDGTKEFQTEGLTTTVFVNGDTLFEYPNNTSILDRADGMRVTTYADGTKKEERLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNR9</accession>
    <name>A0A088RNR9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein tyrosine phosphatase PRL-1</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_160240</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN96899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697552.1">
        <property type="nucleotide sequence ID" value="XM_010699250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNR9"/>
    <dbReference type="GeneID" id="22573601"/>
    <dbReference type="KEGG" id="lpan:LPMP_160240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160007100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_160240"/>
    <dbReference type="eggNOG" id="KOG2836">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5632at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14500">
        <property type="entry name" value="PTP-IVa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000086">
        <property type="entry name" value="Protein tyrosine phosphatase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="11">
        <location>
            <begin position="15"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="12">
        <location>
            <begin position="86"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIN96899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="175" mass="19443" checksum="40A6EBB9751830D7" modified="2014-11-26" version="1">MEVNSTLIDCYDPQQPSKVLFHFLILDAPSPSNLPTYIKELQRRGVHHLVRVCGPTYDAALVRGGGIEVHSWPFDDGAPPTRVVLESWLKLLDTELARQQEDPSKPPPTIGVHCVAGLGRAPILVALALVEYGNVSALDAIALIREKRRGAINQTQMHWVTKYKRRHQGGHCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPE8</accession>
    <name>A0A088RPE8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">GMP reductase</fullName>
            <shortName evidence="13">GMPR</shortName>
            <ecNumber evidence="13">1.7.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Guanosine 5'-monophosphate oxidoreductase</fullName>
            <shortName evidence="13">Guanosine monophosphate reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">GMPR</name>
        <name evidence="21" type="ORF">LPMP_170760</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 13">Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23 24 19">
            <text>IMP + NAD(+) + H2O = XMP + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 13">
            <text>IMP + NH4(+) + NADP(+) = GMP + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:17185"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.7.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="19">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 13">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.7.1.7" evidence="13"/>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697767.1">
        <property type="nucleotide sequence ID" value="XM_010699465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPE8"/>
    <dbReference type="GeneID" id="22573819"/>
    <dbReference type="KEGG" id="lpan:LPMP_170760"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170013600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_170760"/>
    <dbReference type="eggNOG" id="KOG2550">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902560">
        <property type="term" value="C:GMP reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003920">
        <property type="term" value="F:GMP reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04601">
        <property type="entry name" value="CBS_pair_IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000003">
        <property type="entry name" value="GMP reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00596">
        <property type="entry name" value="GMP_reduct_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005993">
        <property type="entry name" value="GMPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911:SF122">
        <property type="entry name" value="GMP REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01240">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0129">CBS domain</keyword>
    <keyword evidence="12" id="KW-0327">Glycosome</keyword>
    <keyword evidence="19" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="3 13 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15 19" id="KW-0520">NAD</keyword>
    <keyword evidence="5 13" id="KW-0521">NADP</keyword>
    <keyword evidence="7 13 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="6 13 16" id="KW-0630">Potassium</keyword>
    <keyword evidence="19" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="2 13" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="20">
        <location>
            <begin position="99"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="20">
        <location>
            <begin position="164"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="13 14">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="13">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="417"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="30"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="260"/>
            <end position="262"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13">
        <location>
            <begin position="260"/>
            <end position="262"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="312"/>
            <end position="314"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13">
        <location>
            <begin position="313"/>
            <end position="314"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="352"/>
            <end position="354"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="375"/>
            <end position="376"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="401"/>
            <end position="403"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="454"/>
            <end position="457"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00084116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="AIN97114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="492" mass="51959" checksum="2DE75FA7A46A35FD" modified="2014-11-26" version="1">MAALGGLPTLPQGLTYDDVLLIPQRSPVRSRKAVNTSTHLSRNIRLKIPIVASNMDTVCEDKTAVTMAREGGIGILHRFCSIEEQCAMVRKVKRAQSFLIEDPRMILSSATKTEALEELNWSGRKGGVSCLMVVDDFTSRRLCGVLSKSDLVFAGDSDLIGALMTPVKRMVVSTNTSITLEEARELMHMKRTNNIPLLGPKGELLYLITQSDILKLTGNRNATLDSRGRLIVGAAIGVKNEDHKRAAALVDAGVDVLVVDIAHGHSDLCIDMVKALKANPRTNKVDIIAGNIATAEAAQDLIDAGADGLKVGVGPGSICITRLVAGAGVPQLSAVMDCARVAKKHGVPCIADGGVKTAGDICKAIAAGADTVMLGNMLAGTDEAPGRALVKDGKKVKIIRGMAGFGANISKAEREKRLDEDVFNDLVPEGVEGSVPCKGPLAPILQQLVGGLRSGISYCGAHSIAEMQQHAKFVRMSGAGLRESGSHDISKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPF1</accession>
    <name>A0A088RPF1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amastin-like surface protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_201610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698362.1">
        <property type="nucleotide sequence ID" value="XM_010700060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPF1"/>
    <dbReference type="GeneID" id="22574370"/>
    <dbReference type="KEGG" id="lpan:LPMP_201610"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200050400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201610"/>
    <dbReference type="eggNOG" id="ENOG502SU24">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009944">
        <property type="entry name" value="Amastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297:SF4">
        <property type="entry name" value="AMASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297">
        <property type="entry name" value="AMASTIN-LIKE SURFACE PROTEIN-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07344">
        <property type="entry name" value="Amastin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="208" mass="23055" checksum="FEEB2E89DDB79ED9" modified="2014-11-26" version="1">MEWNLMLLLYAALQFIAFLLVLVATPLDMFRITDNQSIVNGYFSLWGSRQSVGDLSFFSPITILWAACPGRLMRFRVAQALAVLSILVYGAAAVLGVVILFCCPLLRWICVMLNIMGAVTVCVVWAAMVLTYFTDEGRTCPALHSFTVYGVGFALLVAAWVLDLINITFLVVPFHIMLFGKADSAADNLEEKSKGESEEHSSQKEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPU1</accession>
    <name>A0A088RPU1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DML1/Misato tubulin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_204960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698695.1">
        <property type="nucleotide sequence ID" value="XM_010700393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPU1"/>
    <dbReference type="GeneID" id="22574708"/>
    <dbReference type="KEGG" id="lpan:LPMP_204960"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200056300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_204960"/>
    <dbReference type="eggNOG" id="ENOG502QSGH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271881at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049942">
        <property type="entry name" value="DML1/Misato"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13391">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION REGULATOR MISATO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13391:SF0">
        <property type="entry name" value="PROTEIN MISATO HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="677"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="685"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="698" mass="75684" checksum="0051468D14127267" modified="2014-11-26" version="1">MHAEREVITLAFGNYSSLVAAQWANGTSHYDVHHTTLYSECRSANVLGGSSSGNGYVQVPRLLLLDAPYASTFDDVDAWAHKYREEAESDDGGDAAYSPSAASPSPGFRRKASSPPSYRGLRDSAEEEDHRLARVAKAVQCRVFEQHGLGHGDDVGDVVDVQNDDDEDEDAHLLCAEEQGDVNNNADWHSSAIATHRRAQRQACLKRKLFDEQNTATPWWQYITTGLGPDSVTSVKPLQHMDPAGDLPALHSFGYGLAYLRDGGRSSEVADFNDALRRKLEAADQLQGVQCFIDGDGLFGGAAANVLEQLWEEAGPKTPIVQACAFARLPMFVANPDYRAEVAFRERRMDEVALNQLLATLRLSRHTSAVYIPVPLSDWDALFKGAATAASPTEAPQWLHDERATAQLLAAVVDTALYGLRDGSCTSGASSQGPQWYMDEWCRVVRPAPSLRVAAAMGALPQPVSASSELWEFLQANPLLPDAPQLDEHVDRAKDSTEDDASSGQTRLQAKYFPLTHSMSTYSPAQTAGQVLGHAVSLRGAGCLPATLYPAREAMLRYALPLRTSTYLPFLTKVGYPISDTFPAELLFADPAATAKALGGAAGNGGSASAASLRSVLQSVDVGAHVLSTYTTAPMLRDINTKAQAALRYKMDRYCDAYVMERDDWREALDEGLALFDDYNHVPPSDDEDGGSSDGDNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPU6</accession>
    <name>A0A088RPU6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">holo-[acyl-carrier-protein] synthase</fullName>
            <ecNumber evidence="1">2.7.8.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_205010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.8.7" evidence="1"/>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698700.1">
        <property type="nucleotide sequence ID" value="XM_010700398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPU6"/>
    <dbReference type="GeneID" id="22574713"/>
    <dbReference type="KEGG" id="lpan:LPMP_205010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200056800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_205010"/>
    <dbReference type="eggNOG" id="ENOG502SH78">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26719at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050559">
        <property type="entry name" value="P-Pant_transferase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215:SF10">
        <property type="entry name" value="L-AMINOADIPATE-SEMIALDEHYDE DEHYDROGENASE-PHOSPHOPANTETHEINYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215">
        <property type="entry name" value="PHOSPHOPANTETHEINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="4'-phosphopantetheinyl transferase" evidence="3">
        <location>
            <begin position="124"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN97993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="273" mass="30176" checksum="A31097D01662C452" modified="2014-11-26" version="1">MAKILAANAGAWQPSEDDFRSALAQLHRKDSVRHAIESAQATVADQSPPHSCADTKARLLARHLLLHVLTKSDNTQAERLLWKREVHLPISKYGKPLTASYRDGHYSVTHVAEWVCCARSPAAPLGVDIATVLPHDSVLFSLFLSEEELVRTEAVPRKQWPLLFALFWTLKECVLKALGLGLSTKLQMCDISLDNIGLENISVVSNAQPGTIHIASKHHMMLSLRGNANQRWSYSCFMLPGDPSHMVSAVLQEEAVDDAMEVLFVSPQTALQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPV4</accession>
    <name>A0A088RPV4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-directed RNA polymerase II/III subunit, putative</fullName>
            <ecNumber evidence="7">2.7.7.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_180780</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="7"/>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697912.1">
        <property type="nucleotide sequence ID" value="XM_010699610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPV4"/>
    <dbReference type="GeneID" id="22573968"/>
    <dbReference type="KEGG" id="lpan:LPMP_180780"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180010700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_180780"/>
    <dbReference type="eggNOG" id="KOG3218">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="248779at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.940.20:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1340.10:FF:000005">
        <property type="entry name" value="Putative DNA-directed RNA polymerases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1340.10">
        <property type="entry name" value="RNA polymerase, Rpb5, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.20">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00025">
        <property type="entry name" value="RNApol_Rpo5_RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014381">
        <property type="entry name" value="Arch_Rpo5/euc_Rpb5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005571">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036710">
        <property type="entry name" value="RNA_pol_Rpb5_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000783">
        <property type="entry name" value="RNA_pol_subH/Rpb5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020608">
        <property type="entry name" value="RNA_pol_subH/Rpb5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035913">
        <property type="entry name" value="RPB5-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535:SF24">
        <property type="entry name" value="RNA POLYMERASES II SUBUNIT, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01191">
        <property type="entry name" value="RNA_pol_Rpb5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03871">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000747">
        <property type="entry name" value="RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53036">
        <property type="entry name" value="Eukaryotic RPB5 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55287">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01110">
        <property type="entry name" value="RNA_POL_H_23KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA polymerase Rpb5 N-terminal" evidence="6">
        <location>
            <begin position="10"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase subunit H/Rpb5 C-terminal" evidence="5">
        <location>
            <begin position="166"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN97259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="239" mass="27326" checksum="9B15EEFFC0BCFF2A" modified="2014-11-26" version="1">MPAIGQEKLEFYKCFRILQTSAEMMSDRKYKVAQHVVPNSLGEFVERYVEEVEVTESGGAAAGGGFTDAPPRRKQVIRRDKMTLACEREVGEGRTLKAVVYFCPPNHLSSEVVKKIAEDALHEGYQRVVFVTPSKPNPIVRKTMDTYNRSEQDLRFELFEEDELSVNITHHELVPKHTPLSEEELKDVLHAHALELHQLPRILSTDPVARYYGLKRGQVVRIERKSMSAGLYVTYRQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQI4</accession>
    <name>A0A088RQI4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_220890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699089.1">
        <property type="nucleotide sequence ID" value="XM_010700787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQI4"/>
    <dbReference type="GeneID" id="22575135"/>
    <dbReference type="KEGG" id="lpan:LPMP_220890"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220012300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_220890"/>
    <dbReference type="eggNOG" id="ENOG502RK85">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276748at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1168"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1170"/>
            <end position="1188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1217" mass="133858" checksum="092D58702188D4A6" modified="2014-11-26" version="1">MYRARSCGVVATSAAVPRVHTSLVTLTRCYTPIYAPEPATDNLGALRSTDECRTLWAQHIPVPSMTRAIELWLRFGNDPVVHTATPSASVEGAPGDAAPSSTSPFAYVEDYMGSNMVTGAPEHVKESAELWSAYFEAKYVRRMRQSRRTSKQYVGVLGAVGGGRGAGNGSGGSASSSLASLFLDEADHPNTKWDADTFFCEVAYLVERHLKVKATNYLQLEKLLWCGTTKPDAFVQFFEAFQQQTVTRIPLPVPSIWVYESTEAKKKWAERYLPACSSAHHFFQEKLRPHAVDATAQAKLLADVVAAYKQVHAILLERRARQIQAGLYPSTWAGGNAAAAAAEEAWAANEVEKEQRRTDEGIYDPEDLLDTTAEWAAEHARIQAVLERPLTSSGSAGEKSYGFSLQDFWIHTERREALETVHVLESESLTRVAAAARRRLYSETLFHDVLAGLEESVAKARLDIRAAVLKPHFNSVWCRMHYVKFGAASLVQHTHTASRQLLFHYAASVQEVAATAEMYYATKPLSSQLDYASPYTFRRSLAQHCSRYGVEMAHAAQQPLLLSAAYLAKAEGVIGRVVRQAAAPFGVRRRARYNAAKVNNQRLLNPVKSVQVTAPAPELLAAGADPFTVLREEKMPKAKEAGDTLKVWPLGSRQTVSYDWMSPALDKLRLLRLTDGSLTAAQATQRDQLQQAGRLEISMWRRRTAEERQRTRVQAQKEAADVQALMGETPALQEVSAYATHLYTKLTREQGQQQQQSYSDAASTPQALDETNEEWVFAVMLDDNVSLSETQLREVFLPFVDAAGRRLPNGEYRVVVRAVDRELNPTEHPTLMSDAASAPFSVVDALPQLYMQYTQHQPAARKTAGAPAEAPLEGDMAGKDLMPFCAFLREAGLHVSLSAEFAMGQSLDKQGNVSMAEVAAILRGTEYHRSQCEHGITDAQRAIEPQCRLHWSLYHPGATEQEWAAARRCVLQRAIAKERDWWLPDPMLEVVDVRTDSASAASFSFDAYPAVARYSTELCTVLLAHGSNHMEYALLPPAPGGKATTCSTGTQVQAECTVDGTGALVSLHYGAPISTADVTVEDALGAAMEAIQVAQARHNTLSMVKLSAFEKQAQAMLFCGIHGLEFGGKYGRTYAYAFDKAKREMAETAEVGHVASLQAADAEKLRLSDQETTSPAVDRFASQTNPEQRLTRFAPRSTMSGYSMEDVGPSQTSTWGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RR07</accession>
    <name>A0A088RR07_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_230920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699249.1">
        <property type="nucleotide sequence ID" value="XM_010700947.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22575297"/>
    <dbReference type="KEGG" id="lpan:LPMP_230920"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230015400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_230920"/>
    <dbReference type="eggNOG" id="ENOG502SF6A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21001at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="850"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="901"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="986"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1099"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="492"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="902"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1118"/>
            <end position="1133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1346" mass="140505" checksum="AD966F2D9EFD06A2" modified="2014-11-26" version="1">MWATLPPVVSVVTAADELTGVSVAAHTSGMLCESNTGSCPPFTTAATRRSRPYTVDASPVMSPCNASLVSDEHSASLNGSQSGYFHHTAFPPAAVGDGAACETAAPVAPSTVGRPWSRLAPLGFQDATPPLRQLHLERSSFSPLASPRPVEAPTPAPSSPAADFISESLTSRRAAAFPAKGVPDCGLSRSAGAYLSMSVVPVDTRPSPTLVSPCASSFHLVQPSFCTFEQTVVAAAAKNPARGAAYVSAVMRPSESLCAAPKSTPPPTSSDAMMGLGHPAPTGAAGSPNATYMAVNSFQGWSRVPLTAPVPTIAAGDVGAPPGAVIESEAQNNQALVPLVYPPCPTPAPHASAIVNGGALKHSSTPVSPLLNARGSTDCPASVSAALRTSFSMTPVCLSCSPPRHQGEGLLSHSRHAPPPSVWGVGGASLNSTGTAFTVATAGGMTALSPQTPPQIQHFASAKLSSSGSTNTSIGDVGHVHFQALGQPHSPPSLHSPSPRLSSHPSVGARTSPTQPDDSFISITLPNHNQSFYTGTAGRDSLHRSFLFPLNSPGVTAVAAGGVAYSVSDAGPSLEAGSILVDPFCSPALFELPELQPASQQLQGPQPSHQPHPQLQQPLLITPTAAAALSPPGPHLTVFSRSPQLASLDEALQPYASARDRCSSLSQSPALLQLSTCDLQSSVAAAAEASRNESVRNTSFFSPTVANLQWRCRFGESLSGSEKTLAFPDRRLQMTGSSAASAAAGCRRDGVSAKPSSMSISNSKLTPRPAYIVEWEQSLIAFQNRAESYYTFKNTCTETYLTLIEHNVDRFLVCYFSGGVIRPEKSLQEALTSRSGPAVSTAAHVLGWTNAGRSTAKEPSASVAGGGGIQKMLPGSKTLLRLGETGSKWLTKIGANLRRTAETPTPVSRESQTPLMSAGPASRATVTSADAVVSPQRCLGEDYSDCGTASMTVGAAGAGVAAMGGGVLGPTCTGPCDTDPFGAHMTPNTVPGRPTLPETRDSIPLTSTSRPPLPPQQHTELTADTCSTAPTNDMAFLEPVTAEEAEMQCLRQLGPYVANVVPETFMDARPCDGVLDQVRRNYAILLHTLQHVFLNPDGRSRRAADTSLPRVDQTPSSPAALTQTPLPTAATGLVDSSHSTAMDGLISQRIRQGLLLPTIQATWRDYLTPLECKAQELVQIAKTIIDPILGELQAPCDMSATCSAAAVSLSAPVSPVRDLPCDLPAAATTLAEGTSVFANATTNTDRSARETLRASWVDPVSRLIRLLGGDEEYLATIHRMDDEFVENGKAWQECSAQMRLPNMALSDYVPVYGLVLSRLHRLEMEHRTVLELWGGSAAGTQRRTYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RR43</accession>
    <name>A0A088RR43_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_220660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699067.1">
        <property type="nucleotide sequence ID" value="XM_010700765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RR43"/>
    <dbReference type="GeneID" id="22575112"/>
    <dbReference type="KEGG" id="lpan:LPMP_220660"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280038000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_220660"/>
    <dbReference type="eggNOG" id="ENOG502S1XP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265169at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053125">
        <property type="entry name" value="RNA-bd_mRNA_stabilization_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37035:SF2">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37035">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="707"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="805"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="707"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="805"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="391"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="456"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="935"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="983"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1019"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1062"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="394"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="456"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="484"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="944"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1075"/>
            <end position="1094"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN98360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1144" mass="119407" checksum="9D62A4FFC69EC957" modified="2014-11-26" version="1">MSWWNDFSTHRNNGVVDGSPRQRRHQSSDIFSLRKMVTHDTVDHHVHRASSASTQNRSVYIGKTNLSGAGVGGGFASHEPTWETSDHCSDAGSLWQTTTSVGSATRSDQLDVSDALSAWALPSLEEEQEEQSPAREPLPPLLLFPPAHAVNGVQSSFTMGDRRVSGSNSSSSNSSGVYSNGGSIAVPSFTTDYYEPSFMSGTGGVNASAATYTHGGHVLSSTNTIDDITSVVSGSIDDADEDILYDEMAVSTISSLIAALQVRGATNLAGGDALDVEDDEVKNAGGPSQHQHESSACDSYTQADTGRNVDITVNSAASMQQLKVGLTTMSSSSGAVFQDPSASFPLIASLNTTQSSSWRHSSNVYNDSTSGSAVGHNASCSSGLYEASLGEAPSGTVTSASGRAGSGASPRHHGSEMVPLRLTPSVLHNVLASFQSALVERSSDVKLPSSIGDLFSTSGWGTSSQNGSSSSGAAGGSRPYRYDSPTTQEEWGSQASTSPATAGVSVAATACGNKGDVLAVLDAPAMTRNGSPMMRGRVNSVVAHKLNLDVAARRAQLQDLRGSGCIPPAAANIDCTCTSDIHTPTLSAHGRLCVPQHVHTQELAASSDSSVDHVFAHTVSSVPGMLLGRHERGSGLATAEGFATLHHHTRTTSEVSLPAAAATYHGGSALQQRIDDRGCIAVVDPQRRKLHVPLSAIQTTKALNGRLKTPSLCLLYQSGRCRQGDNCYQVHIDTATVERLRVNVKSMPCCCFHHGDCNSYRMDCAAYEGRSLEIAGQFSVPLARVAYTAGLQRVLQDQQMCAPVNPSVLCRLHGQPSGCRFGADCRFVHICCLILQNELASIMANAVATWAASSTLAAAQQQQQQSRLGNGPSLFVDLMHSGLIPSSSGTMHGGANAAMLSFNDAASSAISGMDCSPSQVPQVIPVTTTAASSAFASRVPPPSQQQKSSTPSSVTVQPLPCAGTFLGPSAGTHYTLTTLQPQVSQVQTPAGRPSPLQASVPGSPASVCHAHMHTLSTQSNGSYQSYGGPTLKQTPSHSEVASPMSMGLLMSRSLTTFPATTTAMSSGSGGAFPSLAQSQLHHQATPPQRYQSSALAQQEPQLLHLPQLSQLSTSQQIYVQQMSADGSVSVVPITVMQDFGGGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RR72</accession>
    <name>A0A088RR72_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="2">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_201850</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-1 OGG1 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="2"/>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698386.1">
        <property type="nucleotide sequence ID" value="XM_010700084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RR72"/>
    <dbReference type="GeneID" id="22574394"/>
    <dbReference type="KEGG" id="lpan:LPMP_201850"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200023900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201850"/>
    <dbReference type="eggNOG" id="KOG2875">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="238681at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034039">
        <property type="term" value="F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012904">
        <property type="entry name" value="OGG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052054">
        <property type="entry name" value="Oxidative_DNA_repair_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242">
        <property type="entry name" value="8-OXOGUANINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242:SF2">
        <property type="entry name" value="N-GLYCOSYLASE_DNA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07934">
        <property type="entry name" value="OGG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="11">
        <location>
            <begin position="317"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="504"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN97679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="570" mass="64820" checksum="F6ECD58C43335152" modified="2014-11-26" version="1">MMPPKLISGRGEPPPWRVLTSSLKAKVNLQLTLCGGQCFHWYPTPRCTFVGVLNHSVFELREVRCAAKLKKQDELRHVASQRRAPTLGKRRQESRSAPRASESDINVSKHFSCCWIEYRRLWPLADPQCFSEKVPMSTPSSSLWSTGAPPSLAIEESDEEMLSRYLSLDVDLDQLWQNWTASPQTRKHPLVQYLVGNRLQLHSLLSDRNQRVCEHDKAQKSLYISIRHVRQDLHSCLFSFLCSQNNNVTRITGMIYALCRAYGDQLCDVQLATAEVRTPCKSASDREHKLTKTELRRQTAAHKEDVIASPSLKPHRSSINAPGWLSMYSFPSLEQLSAATEEKLRMLGFGYRGKYIVDTIRFIQTQSPQQELQDNVMLKGQMHPPPHLMRQHGACYRNGFYSTVLGHHDHHHQHQRDMLLLLPGVGRKVADCVALFALNRTHIVPVDTHMAQVAAEYLVSPRAAVPAGRKRSRPGCLLLEGERYPCDDVLLEWRKQVEALKEKNGVSSTSVQTIKGGGRSASASPRSSRKTPVPPLYERHHNVIQDAFLKLFGNYAGWAHSILFYYRMHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRU5</accession>
    <name>A0A088RRU5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zeta tubulin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_204710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698671.1">
        <property type="nucleotide sequence ID" value="XM_010700369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRU5"/>
    <dbReference type="GeneID" id="22574683"/>
    <dbReference type="KEGG" id="lpan:LPMP_204710"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200053800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_204710"/>
    <dbReference type="eggNOG" id="KOG1374">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2588702at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02189">
        <property type="entry name" value="delta_zeta_tubulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004058">
        <property type="entry name" value="Zeta_tubulin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01520">
        <property type="entry name" value="ZETATUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="6">
        <location>
            <begin position="45"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="388"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="403"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="446"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN97964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="589" mass="63571" checksum="5F121BFB1BB83E8D" modified="2014-11-26" version="1">MAVVVVLIGQCGNQLGDELFTQLALCTSSGASSTAVKTSRSVANTSPFFAQDGKARCILVDTEPKVVLGVQQRHPDFIRAENVVYGQSGRGNNWGLGYYGVKTEQSRRAERNAAVQRAFQNIGRDQREEDDNVLGKALQAIHRETRRTSNAEDGSGDFEAIIVLHSLVGGTGSGLASKLTTRLRLYFTEPPSGQHVDEVYESNMMRNDGFDGGVYGVQRRARHLVNITVAPQALGEVATQGLNATLTLQVLQRHADAVLLLRNDDAMAPGEPSGSSVCSAASLLTRCVTFKEANESLVALLLPVLGYGRHPGCITDLLMQCVPPTYLQTTGGNKILTLLAVPQRSYATMRQCVHRAMLFTVKGGRAFMPGYVPTVPIDDMLSRTALQLSGGGSGTVRCGSDGSNERNTRRSGDDRGAQYCPSNHNERPGGAAAAASSHASRRRQRPMPFSVSSPTSPPSSRIRSSDGHFGNADNAESGSAAGSQNEVEEINRCVYYECVRKIPPELYQHYLQLRRAPVAKMFEALDGVLVLNQAVELNRRVLLPLLRSAALKVASGAFMSSYEDVGVKSEQVKQAYREVAKVLATAEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRX1</accession>
    <name>A0A088RRX1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial carrier protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_250220</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699594.1">
        <property type="nucleotide sequence ID" value="XM_010701292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRX1"/>
    <dbReference type="GeneID" id="22575670"/>
    <dbReference type="KEGG" id="lpan:LPMP_250220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250007300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_250220"/>
    <dbReference type="eggNOG" id="KOG0758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="409586at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF48">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="95"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="196"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN98887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="295" mass="32593" checksum="F86E4E0F6419E016" modified="2014-11-26" version="1">MLAGSLGGASATVIEYPMDTIKVRLQDDGKRYDGILQCIRTIAKEEGAVNGLFRGLPAPVIGAACENAILFVSYRLAIDEFQKVTYGHCDPPNQEPYLAVSVAGAAGGVVVSQVLTPAELIKCKMQIQNTLPVDERIYKNSLDCAAVTYRRRGIRGLFRGHTAMMVREAVGCAFYFLAFQYVIRLFLSEGQRFHEAPPWVHFLGGGCAGVAFWTSTYPVDAVKTKQQTMKADYLKLNFRQACARLYKTEGMRGLFRGYSITAVRAFPGNAVLIAVYEQVNALWEYSFKAPGKKLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSK4</accession>
    <name>A0A088RSK4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-mRNA-splicing factor of RES complex</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_250250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699597.1">
        <property type="nucleotide sequence ID" value="XM_010701295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSK4"/>
    <dbReference type="GeneID" id="22575673"/>
    <dbReference type="KEGG" id="lpan:LPMP_250250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250007600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_250250"/>
    <dbReference type="eggNOG" id="ENOG502SFPD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272513at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018609">
        <property type="entry name" value="Bud13"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09736">
        <property type="entry name" value="Bud13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="19991" checksum="A521175924A8A6FD" modified="2014-11-26" version="1">MSGAPVKRRRFDSDDDEDEYVAGASNSPLLQHAVSTPFPTDEMPSLDDGEGEGDTVDTLLSIRVTAPSTHLEADSPTSLVKTTADGPALGQPIAAPSRKPHLPLEEDEDIPAEYKGLISAELLRALFVPLDYICKQRRCTDVLLSQYAPAAVASSSTPGRKLHHNAYGIDPGFRWDGVVRGRGPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RT02</accession>
    <name>A0A088RT02_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_261340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699954.1">
        <property type="nucleotide sequence ID" value="XM_010701652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RT02"/>
    <dbReference type="GeneID" id="22576037"/>
    <dbReference type="KEGG" id="lpan:LPMP_261340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260018300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_261340"/>
    <dbReference type="eggNOG" id="ENOG502R9RN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272479at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="479"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="263"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="495"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="551" mass="59935" checksum="910614D350BC67AF" modified="2014-11-26" version="1">MSVSSSLLRAYVSKCSGARPSAPHSGNAVRHLSYVTNASNFESEVLQSQQAICLIYYISSRSCSAYLKTAEKLVDSINAQTAGLEAPGSTSSSGSSTAKVALSELAVEVNDRQVPEDAEGSATSSIPSSASAAAPTQRTKKMEWLKLCMINADENRNLASAFSVERAKLPITYFVMQGTIVDKVVGHIAEARLNGILIKFLEHYQKEMNVDLLARQSKASGTSGTSASPLPSAATADLLNGTSTTFLQDKIMNALVGADMIQLPEEAEKLDGLRRTLQETKKKAHTELQELHKQLGMDVRRLTDAEMQTYYFNAPQFHAFGVLCALEALYLARSYATLGDVARVNVDWARRAVQKEFEPIQGDPALRRVLALVDVNLVRGELRTAAMLAVQDANRLGSVLAARGADDVHDAQHRDALKEMETLIAGQSQYCVDMLHIIDAHIDSRTLDGSAFPSAVVDQLFELLRCNLKLSRTRLSQPLRDVGTDAPDASSAAESMKDLMDGKTPDTTAKRVRMAQARVPQVQTLIMSLLQLYPADLKSQDARSRLASLIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RT10</accession>
    <name>A0A088RT10_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">UDP-galactose transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_220910</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699091.1">
        <property type="nucleotide sequence ID" value="XM_010700789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RT10"/>
    <dbReference type="GeneID" id="22575137"/>
    <dbReference type="KEGG" id="lpan:LPMP_220910"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220012500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_220910"/>
    <dbReference type="eggNOG" id="KOG1581">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1601at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005459">
        <property type="term" value="F:UDP-galactose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005460">
        <property type="term" value="F:UDP-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN98384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="539" mass="57594" checksum="9D47209345F396D9" modified="2014-11-26" version="1">MLVCVVGINLCFGWWSVKQERAITQPYFIAESTFATSMATIAAASHDARRAAALATAKLNAPPGKPHAIYLSTVYGISLTQTLAGAIVSAMLLGVNSLLQRFMRRRQPQPDLQGSLTANAPTAQDQHQHTELDRRDVLEMLAMGFSNIFGTSLGYAAMRRLSYPVALTAKMGKMLPVMLVGFLWYRIRYPATKVASCLLITGGVIAFFLLEERITSTANPPSVAAGGGSSSSTGPNTKGGKSSSSSSFLGMVLLLLNLFMDGFTNSTQDILVKRHRWSGMSLMMRTNLVSVLCALWLLFLLEFGEQPWHWLTSFSHCAVALAIRIPLMSDSALGRALGAWLGHTEAVLAAPATVPFHDLSHFLSFLAHCPEARHDVLLMSLLSALGQLFIFHTITVFGTLALTAMTLLRKGGSVILSIVVHGHAVQSVQWASLGAVFIGVLLEGYINIQEASRRQVQTAMKGIGAGNHEQHAQERGALYDVAATASSSSSRKAAPVSVTPTPECASDPAEAAATALAGVQALRSIAVPASPPLRAKKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RT54</accession>
    <name>A0A088RT54_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial</fullName>
            <ecNumber evidence="6">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="6">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_252220</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 8">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="6"/>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699792.1">
        <property type="nucleotide sequence ID" value="XM_010701490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RT54"/>
    <dbReference type="GeneID" id="22575870"/>
    <dbReference type="KEGG" id="lpan:LPMP_252220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250024400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_252220"/>
    <dbReference type="eggNOG" id="KOG1255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="260885at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009361">
        <property type="term" value="C:succinate-CoA ligase complex (ADP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000005">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004230">
        <property type="entry name" value="PRK05678.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117:SF2">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP_GDP-FORMING] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117">
        <property type="entry name" value="SUCCINYL-COA LIGASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA-binding" evidence="9">
        <location>
            <begin position="10"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="6 7">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="23"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="102"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN99085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="300" mass="30913" checksum="87320B484C81E4AF" modified="2014-11-26" version="1">MFARSAIRRWINKDTKLIVQGMTGKAGSFHTKAAMAYGTKVVGGVSPKKAGTTALGVPVFATTAEAVKATGATASVLYVPAPLCAASIEEALEAEVPLVVVITEGIPQWDMLRVKSMLLSQNKTRLIGPNCPGIIKPGECKIGIMPGHIHQKGKIGIVSRSGTLTYEAVAQTTAVGLGQSLCVGIGGDPFNGTNMVDCLRLFLNDPETEGIILIGEIGGTAEEEAADFIKNSPIKKPTVSFIGGATAPPGRRMGHAGAIVSGGMGTAKGKKEALRAAGVTVSDSPAHLGKHMAELFATKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTD2</accession>
    <name>A0A088RTD2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chaperone protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_261250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699945.1">
        <property type="nucleotide sequence ID" value="XM_010701643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTD2"/>
    <dbReference type="GeneID" id="22576028"/>
    <dbReference type="KEGG" id="lpan:LPMP_261250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260017400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_261250"/>
    <dbReference type="eggNOG" id="KOG0714">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052423">
        <property type="entry name" value="EMIR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44094">
        <property type="entry name" value="DNAJ HEAT SHOCK N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44094:SF9">
        <property type="entry name" value="PROTEIN DNAJ, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="398"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="562"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="639"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="866" mass="95796" checksum="020A878C4FAD597F" modified="2014-11-26" version="1">MRLYSTRAKTSVGGAYGRSDARDDYYNQVKEDKEDQLLEDEEFAALRDADSDEPMSVTHRLAHKADALDAELRRIRYCLCDRAQFLVDTAPATFSGRPTQVDKVLKRLKGAGNQQQSDGAAAKSPRHGTPAAILAAALRASPYAAWHGTSDPVLRFLSLRLLWPRAGQAGRSAFHGGAPSHGAELATLEADLDYLRRGRSLNQLNYYSRLNLTPKRHIWMSLYQIMWNCVVSAQDAVGCVVFGTLRGMKGHGVVQGACKGTAIGLIKALEFLCYGWVVSPLLHLSRGLCNTLYGPVNSITGKYMFDALSGRWMRCTVADSRVFRHELQREKRVLRTVGRAEFRRKRMKVQHRWADCMASMGFRVDMMKDMFMQKEAGGPHGASAGKEGIGGSSNEMRNPYEVLQVCRTANTQEIKKQYKKLAMVFHPDVAQSHRSGGGPLSPEEKAEAQRKFEEISSAYQVLSNPEKRKAYDFGGAQGVRMHETKFGKFMSRTPAEIVQSVFGGEGFRRVLVGELLRSHWALRNEAQVSVSIHELEELQCIRVRQVAVELAAIADVHAQRPTTPYYRGAPGSAGAGGAQGSRRRTTTSSASSSSLPDYLKSGKARCSPIATSSCRGNTSGTGAPADIDMDREMHNSIMEELGGGSGASGSGGKVTLTGQARLSPKGTMSAASSVSSAWSSSPFVLQPGSNEYNCFSRDFEERCDRFVRHMAEACFGKALLYEVGEAYVVGAQRFLGIRPFYAPKMLVTRKVFTGMDRIYEALLDKRQLTPEGMSRKLMVEYFNIEYDTVVADIHCVLRYAVQMVLQDVVESDEVRRKRCYAVWYLGERMMAVGERWTTRIMNDEDLAAYIQQAATAVATTSKPPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTL1</accession>
    <name>A0A088RTL1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heat shock 70 kDa protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">HSP70.4</name>
        <name evidence="6" type="ORF">LPMP_261220</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699942.1">
        <property type="nucleotide sequence ID" value="XM_010701640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTL1"/>
    <dbReference type="GeneID" id="22576025"/>
    <dbReference type="KEGG" id="lpan:LPMP_261220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260017100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_261220"/>
    <dbReference type="eggNOG" id="KOG0101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="242658at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10233">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="619"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN99235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="646" mass="70997" checksum="032CC7961EA453F4" modified="2014-11-26" version="1">MSSTNAIGIDLGTTYSCVGVFKNEQVEIIANDQGNRTTPSYVAFTETERLIGDAAKNQVAMNPSNTVFDAKRMIGRKYDDPDLQSDMKHWPFKVTVKDGKPVIEVEYQGQSKTFFPEEISAMVLQKMKETAEAYLGTTVKNAVITVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAAIAYGMDRKEEKGEKNVLIFDLGGGTFDVTLLTIESGVFEVKATAGDTHLGGEDFDNRLVDYFATELKMRCGKDCRANARATRRLRTACERVKRTLSSSTIANIEIDALYEGTDFFSKITRARFEEMCRDQFEKCLVPVKKVLEDADMKPQEVNDVVLVGGSTRIPKIQQIVSQFFDGKELNRSINPDEAVAYGAAVQAHILAGGQSSKTDGLLLLDVTPLSLGVETSGGVMSVLIPRNSTMPVQKSQTYSNNADNQRNVEIKVYEGERPLVSQCQCLGTFTLTDIPPMPRGKARINVTFDVNTDGILVVSAVEESGGRKEAITIKNDTGRLSKDQIERMVQEAEKFAEEDKANSERVEARNMLENYIFSMRATLDDSEVQSSVSQEDRQKIQGAVSVAANWLDCNPEAAKKEYMEQTKIIEGVAHPILSEYYKKRAMEAPPSTGATAQEHQDGAATGAAPHAEDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUB9</accession>
    <name>A0A088RUB9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_280730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700414.1">
        <property type="nucleotide sequence ID" value="XM_010702112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUB9"/>
    <dbReference type="GeneID" id="22576518"/>
    <dbReference type="KEGG" id="lpan:LPMP_280730"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280012800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_280730"/>
    <dbReference type="eggNOG" id="KOG1109">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2016540at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="515"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="71"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="582" mass="64638" checksum="78BCF9B21050BA76" modified="2014-11-26" version="1">MTSELERAQVILARERRSIGLVHRPIRTILLFLSYSIRGVVHYTEAALSKRFFNTAFLPLMVILFLISYYMVPSPAAAVFSAFDLNRDGQVTATEVNSYYTTVLKRRGGGGTAAIAAQIVGNRESISIDQFSEWWQSPTTDAQRYCAGVANGWWREVEYWLADALYWVVLGVLSSIGLGTGMHSGLLFLFPHIYRTCAAVQRCGNANFWTYPTNFFYGPRERLFVCITPESEPELAASRMSLAQYLVKVVPACMLWGAGTAMGEVPPYVLSYAAALQGRHEDDLQESAAPYGIMSLATNWTLQKVRRYGFWAILLLAAWPNMAYDLCGMACGQFLMPFSTFFSATLIGKAVIKVNLQAIFFIILFSGDVIERIMQSVGGNAAALLPAFFHVEAAVKKALYAVVRARESIAKRAKDGDAFSTAPEAAGSESFLVQAMHWFVVGSVVWFAKSIVESFARSEQERRDEDTILELELALRHRYQNPAPVTTLEFKQLLAAAQFDAQSSEGGIMYAAMHYTRLLLAIAAGLFAWGLYNHRGRASSLGFTLLLHRYLDHQLSANAAARTGMRQVLRVALLAAVLYVHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUC9</accession>
    <name>A0A088RUC9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_271350</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700222.1">
        <property type="nucleotide sequence ID" value="XM_010701920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUC9"/>
    <dbReference type="GeneID" id="22576313"/>
    <dbReference type="KEGG" id="lpan:LPMP_271350"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270020500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_271350"/>
    <dbReference type="eggNOG" id="KOG2130">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="424465at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000045">
        <property type="entry name" value="F-box protein At1g78280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050910">
        <property type="entry name" value="JMJD6_ArgDemeth/LysHydrox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480">
        <property type="entry name" value="ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480:SF21">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="7">
        <location>
            <begin position="355"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="200"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="234"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN99515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="594" mass="67589" checksum="9ED216F623285AEB" modified="2014-11-26" version="1">MQTWYRPHPYGIYPRGNAVKRSDIFDRLGTLSLFTTATTHDDKEHTEQPYLDLVQRVLAFLAVPDLCRLSRSCTGWYVLVHCTDAFKTAYTALSPSYLRFRGSWKETAVRGYVAAHDHTSDAAPVTSTTHRTPYKKSRVESKGKRAAATLVGETPVAFVSHTPVCVRHHFFCDQLFQAWMCTILPPYYHLHTVTEEREEASSSFSSSSARTEKCAGQTYGSKDRRTQRDAAWPASTTRLADSVDATQSHSPPYISKFRPVERRSCISVAEFHECFEKPNLPVVITDVATEWPLFKILQGRFTNLADKKDSLMRSGCPVTSPLRCEHTNMNLEDYVHYATEQNDERPIYMFDAEFGSVLDVERLYTVPPCFARDDFFSILGDRRPKFRWIIAGPQRSGSSFHVDPNYTNAWNANMTGRKRWLLFPPGATPLGVVPSADMAEVATPVSLTEWLLNYYDTTLQELQHCGYECICEPGDIMFVPCGWWHYIINLEDSIAITQNYVSRNNLPKVTKFLRAMKGSISGIDEDADTSTEESTAKRQRGFAKEFEAAMEVAHPALMQDVARQLDEERQEREKRRLGRLMLLDPSSEGFAFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUZ4</accession>
    <name>A0A088RUZ4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Translation initiation factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_252210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699791.1">
        <property type="nucleotide sequence ID" value="XM_010701489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUZ4"/>
    <dbReference type="GeneID" id="22575869"/>
    <dbReference type="KEGG" id="lpan:LPMP_252210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250024300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_252210"/>
    <dbReference type="eggNOG" id="ENOG502S81J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266975at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="170"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="211" mass="23693" checksum="2D948366DEB84BC5" modified="2014-11-26" version="1">MDNYDNAEHDNFGYEDDEYDDAADDWEIEAAEEEQKAIAEEAARKARLEKKLVTRAPVKKEEEEEAVPEDVERAIADMRQVANDIASGSTLLRGGSSEELIGNHKLVADVDVDRVGAMIADRLTSFSESSHYDKLILEVFERLTSHLTNTQLLNEEADRVHRLREELKRAAKTKTKPVEKAPVTQSSLDLSNFEDKGGAAVTEENEDETGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RV10</accession>
    <name>A0A088RV10_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_290470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIN99997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700940.1">
        <property type="nucleotide sequence ID" value="XM_010702638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RV10"/>
    <dbReference type="GeneID" id="22576811"/>
    <dbReference type="KEGG" id="lpan:LPMP_290470"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000043600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_290470"/>
    <dbReference type="eggNOG" id="ENOG502SB10">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271786at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="298" mass="32997" checksum="17726AB390442ADF" modified="2014-11-26" version="1">MGKRVGDEARQRNGIAVQRMFQRNAGLRARTAAQLHHDRDERAAVRAAGDRCDGCGSAGPSLRVSSTSAAALVGAVAGEGGGRRPEWCAPDCRGSLSRASLDVSTYLSRQMDLAEHMRTLSLDHQRPLLDCAAPLEGGDGASRSCFLLEVQKARHARDIDRLPADARLTPHEAQKAQWKAYHHQQAVLRHEQTIPRRRAVDPYVHLTGAQFGASLAVPNAYTAGRLAERNGGRWALDNPHRQQLYKGEPVMTRIMHGEFYSEGAARYAAGVPRYDILAKNRRDVRVASEINRMERQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RV49</accession>
    <name>A0A088RV49_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ADP-ribosylglycohydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_282760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700615.1">
        <property type="nucleotide sequence ID" value="XM_010702313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RV49"/>
    <dbReference type="GeneID" id="22576721"/>
    <dbReference type="KEGG" id="lpan:LPMP_282760"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280034100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_282760"/>
    <dbReference type="eggNOG" id="ENOG502QUQ7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410104at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="entry name" value="ADP-ribosylation/Crystallin J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050792">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222">
        <property type="entry name" value="ADP-RIBOSYLGLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222:SF17">
        <property type="entry name" value="SELENOPROTEIN J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="413" mass="44212" checksum="B09B29973C3D5C25" modified="2014-11-26" version="1">MMVATLVHTPPPVVGNFYQSSFKQLSMAQQKQVGLLVGVAVADAAARPLNGYTQEQVETYLKNKREETRGAASGPTTVAETESSFLAFARVPPQEIKVRNDAEHSSEDRSPVASSSLLASSSAPHFVHSFTYQLYFEVLRAMSSARGEFAVDYVQERLVRVAAEVDAQQTFAAEHASLLHTLCTLLPTPAIYPYASDAALRSYLEPFTAFLTESPMPLQVVDADCGSLAEAAATERAAVRDYTFSVLGVVLRQLQSNPDATRNAAFMAVPGTGAVFPADVRPFVPSTVAAPAETHASPCRVQRHVTTRTTSMSSSAMAGTGWLPRRCTAADTATVCEGLSIARGPVTFAQGVAQAIRLGGPTCQRAMLVGALLGAKLGVRHIPMEWLSATADHKPVSTMALEVAQWSWNPPHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVP2</accession>
    <name>A0A088RVP2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_290350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIN99985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700928.1">
        <property type="nucleotide sequence ID" value="XM_010702626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVP2"/>
    <dbReference type="GeneID" id="22576799"/>
    <dbReference type="KEGG" id="lpan:LPMP_290350"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290008700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_290350"/>
    <dbReference type="eggNOG" id="ENOG502RYS3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275564at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="174" mass="20896" checksum="A7D10DA6A7B70D38" modified="2014-11-26" version="1">MLRISRALLAEVTTINSTTASVSGRLIRIRKKSKWIDRRSTRVPHNGKDIWYFGDQPSCALCHVRFRFKQDYEAHKESELHVNRLRWVETMDWWRETGEPAYLKASNEEWEWFEQHVLPTKAQEMGCTLDEARRVYRQATMTETPTWHRLLQCPTVRQEVKEPRDQRWPASPKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RW54</accession>
    <name>A0A088RW54_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_271170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700206.1">
        <property type="nucleotide sequence ID" value="XM_010701904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RW54"/>
    <dbReference type="GeneID" id="22576295"/>
    <dbReference type="KEGG" id="lpan:LPMP_271170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270018900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_271170"/>
    <dbReference type="eggNOG" id="ENOG502S2MC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="278408at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="244" mass="26742" checksum="F05D6A458193278F" modified="2014-11-26" version="1">MSGAGRKHRAKHLTQQYLDTSGWVGPKEGEALAICLEAPHGQHVRVLLLAHSSSAAAHFPSEASVPHGSSSHDAPHGAKESEGNVSASPSTAPFHEVEKVVHLPRKFHKVIWLSIKDVVVIADGAVSFKPSPEQVENFLKDPRNEGWRERVVVAQHRAENQRVALQRMPQYSATARTTTSVLTHPQVRSGVRMAADGASEQDGEGSEGEADGVYNPNWRNIKHQQQFFGLDDDSDEEVEEEEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWC2</accession>
    <name>A0A088RWC2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_300840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701119.1">
        <property type="nucleotide sequence ID" value="XM_010702817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWC2"/>
    <dbReference type="GeneID" id="22577138"/>
    <dbReference type="KEGG" id="lpan:LPMP_300840"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_300840"/>
    <dbReference type="eggNOG" id="ENOG502SJ38">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273616at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO00319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="363" mass="39905" checksum="7F88B0194EDB8312" modified="2014-11-26" version="1">MTTLSTAQEDAHAHVVMKEAPHIEKVEWTGGMDCSPTQKLTRQVDFSLSQSTSVKANDVVNVEKDWANTHLVERDEVVDAIQCKWWETLDADVRPGLLLPSASTTPMKVGTPDAETLGLVRELLSHASDSAPKKTAVRSSDNALLRCEVPLSKRKEQRTCLDRSPASEVPIELRKHAKHTASRSFHPTVPRGPSLHTERLAHLRGQCVSTATMQRSEGEIDRGKACRCSQDHDGVTKDITVAFQLSSRPEGQCRCERESSSGTGTATPLEAQSEVFSPSAVLQGVLCAHTKGISLSSATAVRMETLQQREELLLLRRSFAMWLTAASQRYIQQCAASYHCFLMQCINDTIGDTTSRVKRGVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWK1</accession>
    <name>A0A088RWK1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">40S ribosomal protein S30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_300710</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eS30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00306.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701104.1">
        <property type="nucleotide sequence ID" value="XM_010702802.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701106.1">
        <property type="nucleotide sequence ID" value="XM_010702804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWK1"/>
    <dbReference type="GeneID" id="22577123"/>
    <dbReference type="GeneID" id="22577125"/>
    <dbReference type="KEGG" id="lpan:LPMP_300690"/>
    <dbReference type="KEGG" id="lpan:LPMP_300710"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300012500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_300690"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_300710"/>
    <dbReference type="eggNOG" id="KOG0009">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="256855at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006846">
        <property type="entry name" value="Ribosomal_eS30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S30/UBIQUITIN-LIKE PROTEIN FUBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650:SF15">
        <property type="entry name" value="RIBOSOMAL PROTEIN S30, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04758">
        <property type="entry name" value="Ribosomal_S30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO00306.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="100" mass="11407" checksum="5A9AF6469FFAF18E" modified="2026-01-28" version="2">MKHRLLLPFFTSTVPLLCHLRFPQYPLQLLIFIIMGKIHGSLARAGKVKNQTPKVAKQEKPKQPRGRALKRLKYTKRFLAKAVKLGEKVHMNKQPPGKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RX03</accession>
    <name>A0A088RX03_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_302580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701281.1">
        <property type="nucleotide sequence ID" value="XM_010702979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RX03"/>
    <dbReference type="GeneID" id="22577311"/>
    <dbReference type="KEGG" id="lpan:LPMP_302580"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300030500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_302580"/>
    <dbReference type="eggNOG" id="ENOG502SRMQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270934at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO00481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="115" mass="12547" checksum="51C56EBA88F19265" modified="2014-11-26" version="1">MQCPWDEVMTEAFRRAQMAGRVFPQLCDFPSSVPGDVVQLTYLKPLRALNGDDRGGAPMHAAPLLCGPLEVTGFFDPMEDEEESLLMTYGGDAWASALFVASHTRSGGGYYNGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RX77</accession>
    <name>A0A088RX77_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_310120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701404.1">
        <property type="nucleotide sequence ID" value="XM_010703102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RX77"/>
    <dbReference type="GeneID" id="22577438"/>
    <dbReference type="KEGG" id="lpan:LPMP_310120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310006200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_310120"/>
    <dbReference type="eggNOG" id="ENOG502S58N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277508at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="15650" checksum="5D34820C233CEAEA" modified="2014-11-26" version="1">MLRRLGMLLAKPRVVPRRPTVHATSSCKKGKRRFDLLHALQKDRQRIERNRTLPWRERLDQLRVYPWKLFFAFMVFWSWMGTYAVPFLKGMKPGELRSIGERRPIPAEVRSKAAPTPQFAHLKERELKVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXJ4</accession>
    <name>A0A088RXJ4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calcium-transporting P-type ATPase N-terminal autoinhibitory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_290490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIN99999.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700942.1">
        <property type="nucleotide sequence ID" value="XM_010702640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXJ4"/>
    <dbReference type="GeneID" id="22576813"/>
    <dbReference type="KEGG" id="lpan:LPMP_290490"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000043800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_290490"/>
    <dbReference type="eggNOG" id="ENOG502TAYN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9997739at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99999.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1188" mass="128141" checksum="43C368BC3CFF0977" modified="2026-01-28" version="2">MASTERNPTSMIPDGVDNEQRFSKCFYAYQESTENHAVGASLFSDTDASSSSVCRSAEDWGILWIHVFPLHISGYLCVRDIIEVARVCRMGHSAVQQPWVWRSLAVHHHSVQPVALERTFSIAARQWGEERPTETMQRLRVYNTPPLLTEVNRRTSEHRVRFLVGSTAYTTAGGGEDASSEEVETGEPDAPSNDEGTDEFDTAQLPHDVDAAILSSAAVPTVVAATAVAAFAPASSSALAEEVGSSAPRSSRAALPSSTSPRFLWQTAAAAMPSPSSPVSSPPPEDDKAAGTPAVPSSALLPREAEARGSTPLLSMTTLAAAPRGAAKPNLYASPQSGMLTSLTEGQCSSPILNNNGTGSSSGEKWRAMRWATTQECLPPPSPAQLKSTVTSTEAPAAGDVSPRASFSAGSLRRHPSYVLEMATEVAVDGPASPLPAASFSSAASRDNSFRQVALSTPVVYSFTLCRATAERTVLHSVPEFPWKMFTQYLHINRVQRSLSQLAALSNTARAELCHGGTWDAAYGALSRAIHELFQSGGCRSVEHLTHLAETLVRRASLCRHRGHLYVLAAFADLSVAWMLCPDSTSSSDLVQLCAREELSHESPATWLQRCNDAAHIASPVALPSIIAQVPTLFPQNRTLCFCAMLTFYMYAKRTLRHSLTHLLCRAAECVTPGTEEELLMTALREVAVAQQSKEVTSAQRACATADYAFSLLPLHVRSAAETLTAAWVRDCFPPDGPASTATITGWADVAPESLSYIRSTPLEVRWLAWLVCEVRWFAYEELMGSLPGQTALLSIVFGPTTHSRADGLVRLSMQYANADVHSEDLRPALPYGTSRGHLAQSLLESALQLRPLHPSAAVLLARMHARDVESLVRANAVLTDSIHAWAQRFSMLEMRGSAEVRRSAAAKDQQSLPGREGTDVLAYLHRRDRRPEVCFIPSELLVERSRCLHTIADMAEATEQHPNLSYPYQMRAAMAMDRGYHLAAVMELSRIIALTMDPNDVALRVRFLQDAIAMAASAIEVGASPEAAEGTADLTPTATATAYDGNHISDGGLVLASNVNASPLSSLQLVPLYRAWMAKMLGFLTLLRPPESTCPGSQQLRTRFLGREWLAAPSGAWPPTSSEVHVSRVASIAFSDGDEEDALASAAAVEFDAVYVRAFLEDLLSPTALPFGVMVIDSGARTPALTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXM6</accession>
    <name>A0A088RXM6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_320300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO00918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701718.1">
        <property type="nucleotide sequence ID" value="XM_010703416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXM6"/>
    <dbReference type="GeneID" id="22577771"/>
    <dbReference type="KEGG" id="lpan:LPMP_320300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320007800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_320300"/>
    <dbReference type="eggNOG" id="ENOG502REBA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="242351at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1056"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="763"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1095"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1160"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1190"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1103"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1166"/>
            <end position="1179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1209" mass="131342" checksum="3D6F5A9749C412DD" modified="2014-11-26" version="1">MCAYALVSMMNRRFRGRHCAAVIATLALFGVLLSHADQITYLGVFPAMEGETVVNVLSVGALKAECPGGVLSYYVDAAYGNNASFPRLHDPTLEFTAPFTGMTMGLRSTYVDLLVLCNVITPVGGTSRVYYRISPGTTTTTTTTTTTAPIMQCSGNYNYSLTLSSDGTFAEQIASLSARATAAGTFCTSGTILATLEPPTHGTVRWNNSGIFYYTPFTPKVGDAVDSFKFQLTCSSEGSRCYGTALISIVDEDKDEIYYAMEGAIVCRGTCDAGAWRTKPTDLALFDVNKTGVAVTPRKDSRSEDGVDFDFTVKGNLIIHAYTTIGNLAARFVTFSPISKANAQGFFDSTSVLDGSHVSFEPSCLDKQASTGKGADIWSWTDMNELKGHLNTLADAYKLGDNYYQKFGGNHRHCDVYRLDPCKYAPLMTPTLGDKSKKLDSNATPSVRWRLYINDCDATWVGRASVESLRALRQPDGSPTFKLEGKGTYLVGIVYSQSVKPANWNIPSAGIVHTETAYQLRLKIHNIIIVDAAARLSSGFSVPQLQMNSDIQYSTGKRTDTRERLYRYSVLLYPYFAANNTAANITSLSLTVVSTTLLNSTWTSPSKIECPMCTGTMTSCRGTGNGFETDCGDEALITFEALDYNASDFEGSITNEGISGKSASTSVSPNNALRVTFAARANGMGSVEATGAYPVGTFAISVKLSSGQVFDVVVNQTDYISELNTRFLDTELCRPSAYWPVPDPLGSSVPVKPYSAEALAFLPGTSTSEEEEEEEKSESYYDTPERLTSPSMCATAPNKESTHIHLDNMTAIIENEKGNVTVSMCAVADERTFGPTDWVMVSLPRIHEETKKINSEVIQSIVDDETLSNDSYTVAQLQYLTLSVRVSEVMSSLLAGSLAKGYVNILLDGDNAPRSRRREEEIWMYPESNSSSDQSDAYLPWEMYASSLSYRRIAHNTNANASETEPFNFAFIPGSLLHSGSRIRVPMIIRAAIKFVTYAFTEANSTHSSQRVKKHEREEALLYIVSVSRSISAALRFDTDTYNPVITQSGIAAKPATAILIVLIVAVVCVLGAFMYVEVTYKRIIHNAKYHPKGPDSPVGIRYGRDGKPKENQKAAKEGSRTEAAVSFSAFTARTAKGTVAGDTTTSSIKTKFGVVRGEQKRVPESVAGSSSASSEADSAAKLMDGYIVENPPIGEEQPRVEDGEVAEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXT7</accession>
    <name>A0A088RXT7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_311400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701531.1">
        <property type="nucleotide sequence ID" value="XM_010703229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXT7"/>
    <dbReference type="GeneID" id="22577566"/>
    <dbReference type="KEGG" id="lpan:LPMP_311400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310020000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_311400"/>
    <dbReference type="eggNOG" id="ENOG502SIIK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265308at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="593"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="828"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="412"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="841"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1042" mass="109302" checksum="30C45D3C1C70E958" modified="2014-11-26" version="1">MLGGPTRSLHVLWGQTLARYVPPHSPSGLVRGHLLHRYPVSGAVAASSPVQKGDAEVEAYVSAAEWLPARTPAEVVLNANEFSTVYAVPTASPEDVRLCTRYLLATSSTTAPVAVGNPSLRDGNVTTATVMSNLQDTATSTYEASPGRKRITSAPLASIITTLCALRHVLGEHQRLLAGAEALQTGVPISCILAELEEAQLYLTWSLGSHQSGPLTQGVLPRPCDLVCGDGRSDHISVSAGLREAMSSLAGGRVLEEGGSGGAASAATSHQTLDSRERRIKERVGLLLQRFQREVACLHSCGPRSTLAEAPLELMPINAEGAQGKPFLPPAEPRVPLLTVVTSTGSSLAAAMKAVAVAWACCACGVRGDSASPLRCCVYAADILWRPAPATAFVATWWTALLHQYQRSSRAANSAGNSHSSPSNAAAQSGLKRHAPPRTGAASEGSGGCHSVSGNHSEESSAAASSPSLRGLCFHVLITGGDTVDHFLLPLMAGVNDCSVGTPTTNAQRSGRIDVTAQNDDCGGGDLTRPCRGDAARVSAAVQSVTRHKPGRLAMLLCYGCPAAQVAHLREFHHSCLLRQDMAKSSVAIESRGALNRRSDEPAITDRESTAATPAQCDNLPSMERVGCAITGVVELCTEAPAVSMVAALPRASSATAGSSVGTSSALSLSYYLRGAGLSLSLPSEPQQLLSTLTASARAMTLDEVAARVFESSLLERPLRHADFHDCHRGTCVNNSPESPYEPQTVAASAALHGGASFQRGWCSLCFAPQTHAPALLSTLAQSHFRQPLRAGHSFDALCRRGPAPSPSHMQMAQEVLRCATRGECTHRRIPQGGRQGSKHAGASSSPSLAPASVASTSAPTSASERACANERSLHCGVLPEVQWKHVCGGFPLPLTAIGGRSTPYFVPCLLFTDLVEVASSIFTKKQEGRLSHARSDARQLGWPAAPTSLDDRGSLPQEAHCSGVGVSPQAALRHSAGEEFRAEQRQVACAVAAVEGSVSELRCAHDTEMVGYRGVVAGNYLFVCFYPDAWQDAVTDALMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXZ2</accession>
    <name>A0A088RXZ2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Symplekin C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_312190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701606.1">
        <property type="nucleotide sequence ID" value="XM_010703304.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22577645"/>
    <dbReference type="KEGG" id="lpan:LPMP_312190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310029100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_312190"/>
    <dbReference type="eggNOG" id="ENOG502QXUH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272013at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021850">
        <property type="entry name" value="Symplekin/Pta1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022075">
        <property type="entry name" value="Symplekin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15245:SF20">
        <property type="entry name" value="SYMPLEKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15245">
        <property type="entry name" value="SYMPLEKIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12295">
        <property type="entry name" value="Symplekin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Symplekin C-terminal" evidence="2">
        <location>
            <begin position="1357"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="813"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="813"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1503" mass="164386" checksum="F4B4425F13C4248E" modified="2014-11-26" version="1">MDTLMSAIESVDSADTLDLTSFLQGLSDLDEVRQAVEMLLDAYNSHSGTSREALQKQCVMRSLAELLEAVHSRYTRTADASAAPATCTFWRNQTDRGTAANSSTDPRWAFTADDYLLLSMLLNETATTTNATTFAYWSRATVVVFSSATAIVFPSADMSGVCPEKAGATINKEAETTRASLESELHSLREIVAKRFTTAVESLRRVTSYEYARRSLQSSVWALLGSLAGCSSSSVGERVVEELEAAVESMLQPLNIALQEPLAGSHGGIVSCQTGGVTGSGSRSGKKTSPILLTALLQDVEDVLWAISHIAASSSSSATRQASSLLEQLCSRAVAFTVEVLLKFAQQYITLQQQRQMEFMEKEGAGGEGDGHGGARGAKRDIFRVYHVQRSVQRVLSVGLQLRRVVFPASTGSKAAEVSLVSEAAFNGLQAAVSAFGGAVFAINPVTRAMTKEDIDDDVFAVAAATTTEEERTSPLAWGNDSSDAGRLRECRRVLAPPHHLTTSGGVVGGVEGNYDFFKDEEGDTLLGRREAYLKTSLGPVTASALVDMVMLTVSHMDFLSEDAIQELHRRGLEQMQLAAAYQAQKEEVEKLRQMERQGVEAIAAGKLIEHVKDSAALHMRGIQLLRKVSARSRLERAAFTSVLGAYQHVRGEAEAHIRLTQALISRCLVQLPPSLADSAMDELLLHLRRELTRAQAQKEAAASGKTSTTTAHLNTDVASLFLASSYYQLTLQVLFMYYATQAPMHERSATWSSALLLGGGGAVAHGEDDGAGLDDAGPHAGGELIQTEAGFSIEVDNPIAFLYDDDVHRASQDVGQKRSREEPEGGGGAGDEDALVAARATTGEHDFGFLNDTVAAPSTYSHVLCRVLELIRTARLNLILLDLLLQAPVLTRYVWYYLYKHFCLSADKASCVIGMWLLRNLAVRRPVYRTCAVNILLQLCLSTHDYARRFAIKEIDQLLSATTTQGAPVLDQAAEGHLLRYAKKQLFAIPAYQRSSSSKLKRAHDGGEAAHVDEGAAVTGDTDEATAKDRVRMSTVLNRRLGLFLMLCARQPRELFPALLEVFQQCVERGNILMMQLLPENTDVRRMTQHLLKTDASNFVAAVMPLLRKRCREARPLVQSMLWAVREQLGAMAKEANSMANILEGSSDGINTASQASSTAALEALRNISNAILGHAKAMYELSGIPLGNSTQSVSLLDIRYLAPFLSFLSATELKQTYLNAFLLFLQVQLQFQRHYSNAFHQLSAKERTYVLEATELHAFQIKVLREVLVKCPVPFQDGVLRGLTRVDFFVYLHRAPQESQSRLASSMLSHPLHGETLSSTTGGILDGMHNGGETSLSAANGKKTEVLPPISVGTTKEVVSLCFELTRSFDNTTVEKLYGPPEVQKALQQLMHPPPVPSQLMATVLQAATLFLRSRYMEFIGFVVQTILTPLERASVWETDPQLWKGVILFTERYYRECSNFLVNLPDQVLTQALHEHPQLCGYFKEEHGNNASFMHVLGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RY90</accession>
    <name>A0A088RY90_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Serine/threonine protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_320870</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO00974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701774.1">
        <property type="nucleotide sequence ID" value="XM_010703472.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22577828"/>
    <dbReference type="KEGG" id="lpan:LPMP_320870"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320013700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_320870"/>
    <dbReference type="eggNOG" id="KOG0198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275301at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001274">
        <property type="entry name" value="Putative serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584:SF369">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="512"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1088"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="953"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="1116"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIO00974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1353" mass="148593" checksum="2D7FB8134F128F64" modified="2014-11-26" version="1">MYIQSCLNQSNRNNMSLSMSLQKQKDANADEGDYADGRRIMIHNPLKGHLFSCSSDSSLDNSIYRPELIVAAPSSAQKASSDLGNRLDATLGFCGEETAQGLVAEQVEGPCDEKRVNLIEVRAIDSDDEPSSLEEQEPQVCCTLSSLPTFASIMCLGAIVVGLLGFLPFYVVGVQSNSRTTEYLLREVMTSVVAITQDSLSMLPAFVRIVTFNYMKRHNTTLEETDLAEDPDQLLASLLMVLSRFDTSISYLRLIYAGGLYTSAGYTGLSPADGDQMQKLYGGYSRTQNTVPLLEVYKDSITVVEPPKVLGYFDFHHEITHMGSAMNQIVKTWAANPQNNTRWLPASDNASSTYFNFVMPFTVNGTLGYCEAGALSNVIIREATALATFLREHGSIFLVDATRNILVGNSWGQSIQNRVEDSTSGSAIYVPTRIYEITEPIIRAAMKVVNESGSLTEVLKSRNTTLITFPFKGNNALLNLTRVTDTYGLDLVLGVVALRGDFKKSFSTARTAAITVTVLVVVIAAVAAMMIVWFVVREMKRLIPQLIRASNLEVSHSDKEHRVQGWLAYITEIRCIHEAFVRVERSLREMRTFVPAAVMTLAPSDDSHSDVDLADGKTRRVRTRFNANIVKDNTNEFSRVDVAMVLVDVHRAVDTTEACFIMDIISQRAEEYTGYIESVSSSSFFVNFGTQSQNPLVVSKIRRFAFEVHRSMPESIRSCVVCFAVRMPFLVGTCGARHSKARVVFDTQRMLDISKVLWDIGCHVASTTDTLSHFATSSAQIPWYRIDCVRFPDEVSQVTLCELRDPWSSLQDHANMPKKMGDGLSKMCKGEYKEALMIFDSAHSENVQLKRLRQICVNRVASGDTTKYIHLIQDVYVLDTTSSSQEDMVMGGGAAMFDYDAGVSIDVATSTSGMGDPFKETPVFARSFRGSIAGMPPPVLAQPVAHASFPVAHQAAPTRKSKTSLSPSLTTGGETPELSHLTERAVTTAMGPRELSAGAPLVAGVNGSDPGFPPFHPQISDATTVAASVPGSSPPWGVQDDTESETPSFLTNAFVFESSVVSTDALGAAVQGGDEPQVLRDVNQHEWQVSLYPIGSGAFSFIYLGMSDDGVQVAIKRIPRLHRGIKEEEMVSEVCTCAKLRHPNIVPYISCCVTQSYLAIIMEYMPGGSLHDIIDNFGKLPRTVVRRFMLDIVNGLAYLHESTTHGDVKPHNILLGVDGVCKLSDFGSASDKLTEVCCVDEDRLMRGTAVYISPEGARNLPLTSASDIYSLGISFLEMVLGRLPWKWANDERTDALPLRHNHEFVQCLTANAIVVDIPDDLDNDMRELALASCAENPENRPTAQELLSFAFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYG0</accession>
    <name>A0A088RYG0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">P22 protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_301020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701135.1">
        <property type="nucleotide sequence ID" value="XM_010702833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYG0"/>
    <dbReference type="GeneID" id="22577156"/>
    <dbReference type="KEGG" id="lpan:LPMP_301020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300015400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_301020"/>
    <dbReference type="eggNOG" id="KOG2536">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="278212at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.280.10">
        <property type="entry name" value="Mitochondrial glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003428">
        <property type="entry name" value="MAM33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036561">
        <property type="entry name" value="MAM33_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826">
        <property type="entry name" value="COMPLEMENT COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826:SF1">
        <property type="entry name" value="COMPLEMENT COMPONENT 1 Q SUBCOMPONENT-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02330">
        <property type="entry name" value="MAM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54529">
        <property type="entry name" value="Mitochondrial glycoprotein MAM33-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="191" mass="21627" checksum="2BD28CC60FD36EBB" modified="2014-11-26" version="1">MALMVPCRSASDAALADATRRELEEEMGRSDKPEQPTPPVGWQVERKPGTCTFDLTKSFEGEELVVRYSTNQDSDKANSHDIFAYVTQKNGQTMQADLSIEEGELVLNNIRFYSDAALARDTSAEAEAKRNELYTGPLVHELDYDLLNCVMTYLEKRGVDEKLGEFVVLYSFWAEQQDYEAWLSTMNKFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYN5</accession>
    <name>A0A088RYN5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA pseudouridylate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_301900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00415.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701215.1">
        <property type="nucleotide sequence ID" value="XM_010702913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYN5"/>
    <dbReference type="GeneID" id="22577243"/>
    <dbReference type="KEGG" id="lpan:LPMP_301900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300023300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_301900"/>
    <dbReference type="eggNOG" id="KOG1919">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="418349at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF87">
        <property type="entry name" value="RNA PSEUDOURIDYLATE SYNTHASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00415.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="533" mass="58837" checksum="08D79809E02301C4" modified="2026-01-28" version="2">MPRELRYCRPRHDPEESLLAYLSKKFTYLADAEWREHIAAGHISVNGATLTNESYVLRQGDVLRFAPPRSLEPPVDKNHIEVLYEDSRLMVVTKNGNLPVAEGGRYCENTLVGVLQRCGTASFYTAATRIGTATAHEHREKVSDTLTHTGEVAETTAYVECSTAMGASGEGAQISTPPPSRRRLVDDTHWTAAVDVAPCISALLPDAPPPQQRSPLNLFTIQRLDKETSGVVVLAKHSVTARKLAAQLEAQTKGCTDAVESWLRERGHTVPFCSDVFGELLQLKAHVVHKSYTAVLRGAAPEGHTFVVVNCMDCMAKHPTHSLEEQHTQLKRLKMCCEPLRGIVDASTASSLPTQPTEQRSHWGKLAATRIRVLASNKVLGLTCVHVELLTGRSHQIRLHCAAIGYPVLGDKLYMTTTPGREGGATAVSDAVYLERVRREDDPFLPIDDDLSDTGGTDRTSRMRCRRHLLHATRIAFEHPDISPAHWMTFTTSPVSFFAADVRFESEADSLRFIQWLTGAVSRPLASRDISQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYR5</accession>
    <name>A0A088RYR5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin-dependent kinases regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CKS1</name>
        <name evidence="5" type="ORF">LPMP_323920</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the CKS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702073.1">
        <property type="nucleotide sequence ID" value="XM_010703771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYR5"/>
    <dbReference type="SMR" id="A0A088RYR5"/>
    <dbReference type="GeneID" id="22578133"/>
    <dbReference type="KEGG" id="lpan:LPMP_323920"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320046500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_323920"/>
    <dbReference type="eggNOG" id="KOG3484">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="440676at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.170.10:FF:000006">
        <property type="entry name" value="Cyclin-dependent kinases regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.170.10">
        <property type="entry name" value="Cyclin-dependent kinase, regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000789">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036858">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01111">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00296">
        <property type="entry name" value="CYCLINKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01084">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55637">
        <property type="entry name" value="Cell cycle regulatory proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00944">
        <property type="entry name" value="CKS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00945">
        <property type="entry name" value="CKS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU311113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO01273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="99" mass="11800" checksum="5F2C6D7169B64922" modified="2014-11-26" version="1">MPAKPAQDFFSLDANGQREALIIIKKLQCKILYSDKYYDDVFEYRHVILPKDLARLVPTSRLMSEMEWRQLGVQQSQGWVHYMIHKPEPHVLLFKRPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYS9</accession>
    <name>A0A088RYS9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GIPL galf transferase, putative</fullName>
            <ecNumber evidence="6">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LPG1G</name>
        <name evidence="6" type="ORF">LPMP_324120</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="6"/>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702093.1">
        <property type="nucleotide sequence ID" value="XM_010703791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYS9"/>
    <dbReference type="GeneID" id="22578153"/>
    <dbReference type="KEGG" id="lpan:LPMP_324120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320048500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_324120"/>
    <dbReference type="eggNOG" id="ENOG502SKW8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="259152at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43179:SF12">
        <property type="entry name" value="GALACTOFURANOSYLTRANSFERASE GLFT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43179">
        <property type="entry name" value="RHAMNOSYLTRANSFERASE WBBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="5">
        <location>
            <begin position="203"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="95"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO01293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="578" mass="66755" checksum="9521BED2DA5ED75A" modified="2014-11-26" version="1">MAKNAAAQAMWSRRPFVTYRTRSLFLTSLFLFMALGAVLLFVFSEPMTTLLATPNAELPSDKMSTNVTQMTNSGSNSSLLHTTPISYNTAELSTLWPEPTSTHGAGEDGLPREGETIKPAMHNDSPEMNPWKKMRLPTDWTVCIRRNLQLDDHGRPLYAVEAMEDAIPLLITPLTGDVEFFPFFVCSIDVPVRYHYVIQNERNSETTAVIDRLQRLFGESGRLLIVRNRYNRGYSGSMNQGFEWALKERTEEEVPWVFACGVDVIFERGLLAAMVQVVQDNTRGDAAMLATLRAEVELEERLVREGNYSYYERWVPRGRPLKVLRSGYPGVPLNVRTAPLMPDRIRYMVGDENRRSGIVTEAELKGRFFGNYVATVTPVPFALGTIAVTRLALSAVGYFDENYFPAYMDDIDWRWRHFAYGFKTLYAQLNDPVIRWHHYNAANLRGSPFQDQYLKKYDTEANNSRVAFLQYIARSKRQYDKLKFGPRDLTGVWHESVQEGEYKYTYFNISRYPADTWVLDERARQCMFRHTYSYETQSWQRPKNCAYMPRTLEESGILGVHQLEAYKMMVNKSKIEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZA6</accession>
    <name>A0A088RZA6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_331970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01488.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702288.1">
        <property type="nucleotide sequence ID" value="XM_010703986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZA6"/>
    <dbReference type="GeneID" id="22578350"/>
    <dbReference type="KEGG" id="lpan:LPMP_331970"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330026800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_331970"/>
    <dbReference type="eggNOG" id="ENOG502SI7Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273569at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO01488.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="625" mass="64887" checksum="427655CD0B3731C4" modified="2026-01-28" version="2">MTTLKDGRFMFIHADRHNLLLEQSVKAAAVSPSSTTATTAAAKEGVAAALSLASSTFQLLYGGVVHAFALNATQSHIALVCPAGSAAATSAAAGHLRGDGPSTVLRLFSFSCGEVGELIDELVTAEACDVVWVGSRHLALEVRRFSRGGDGEVAVPSLSTSPLSAPVASTILIEVTKAPEKLRWVRQDEAAASPVSAPGSVLCDIHVGKQSLRFWDLQKGKVMQECGLPNRRCRHGKTRMATATCSDGSFVFVVNDDWTVHGFHVGKRTVRELKPMLSQFESQSVNLANNRGGCAKLSEENNDGHGVTGAGKEAESSMPCPPSKISTPPHKLACPRLFARAISDTQVLLALQGSSTILQCACESKTSRSDEWTVVAKMRLPRRLQATCEVVGLSTRGCLVRQFELTEGSVQTSTAAAPSGAQTGASVNGQNTVAYFVVPLEMKATGKASVAVAVTCGNAGTTESSAATPKTDTVGEESERTSVAPSVPSETSWAEGKRKRKKKSIAVAANSDAPASATSPEAPSASASDTGNAESGSSGRCNAEHPLQRAILRLLVHAGISGKDQFTGAFAKDTASDGVDTAGAAAAAPAACGHEWHSTDTFVTAGGVVIGVVLGLLVMRHFALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZQ8</accession>
    <name>A0A088RZQ8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_333350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702423.1">
        <property type="nucleotide sequence ID" value="XM_010704121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZQ8"/>
    <dbReference type="GeneID" id="22578488"/>
    <dbReference type="KEGG" id="lpan:LPMP_333350"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330041900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_333350"/>
    <dbReference type="eggNOG" id="KOG2562">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10265007at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030865">
        <property type="term" value="P:cortical cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035303">
        <property type="term" value="P:regulation of dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000472">
        <property type="entry name" value="Hypothetical_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039865">
        <property type="entry name" value="PPP2R3C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12085:SF4">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12085">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B'' SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="349"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="536" mass="60550" checksum="93D935B1B559388D" modified="2014-11-26" version="1">MFPYGYSIVRTQRSALEEAYNKKKEYLNARVAPLYASTNPASLWNAIVKYRLVEESGGGESVDTYDELALTYEGYRHMVYDVLFHVTPDEDAAADAQVREWRRSVYFHHPFLSPATFLAFARSSRGAVPAVPLYAFAAKRLLLFRIRVELELNASAPPPIFVDRARRAIGGRLPCPPSASSPLSNGLTQEDIEMFISDLVPNLRLVRDMPPWMLPYYLCHASRKFMFMCDTRGVGAIPIDAFMKSEVFSELLRMFESDTQDAIITFPNGCIVEVPATFASPAAEADDTVAALVLSYEGEGNALSNVYELQLLDGEVKVQVPREQLYWSPASMDYVQAELLSMDNWFSLALMSRIYEHFTTLDADGDGVLTREELSHYSNDSFTQLSIQRVFECHVNHSGTRHIMDYKTYLNFVIATEHAATRPAMRYIWALLDLDGTKTHIKISTLHCFCKEIASELLANGLMVDISAQSILSEIVDMINPAWHEWVTFEDIERSGQQATVLPILLSYRNFYAYDCREQTAAAANDGYADIPELLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZT2</accession>
    <name>A0A088RZT2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_332280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702319.1">
        <property type="nucleotide sequence ID" value="XM_010704017.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22578381"/>
    <dbReference type="KEGG" id="lpan:LPMP_332280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330030300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_332280"/>
    <dbReference type="eggNOG" id="ENOG502S44K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="246381at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="653"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1376"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="84"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="515"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1471" mass="158990" checksum="378B0F8C7148986A" modified="2014-11-26" version="1">MGAFALCVESATRDIRSLLTLHRVHPQVRTDIQRILSSLLRKSYEHTAVPFLKDLTESPEQVCRELVNNIVEDAFKTALSASDMHAMEHRCIKLEQDNADLKAAADQADKRVAEVKEVLSDLKKAHDYMLHSYFREVLVLRHRIDDLQRHLRTRRVHTMNFTPHLGSCTASVIPTMESQLQQFPFNPSTATRQDEPVSSPSPSTLTAPPCGSLGEDSDAGEDFVRQQVSTPISPCREECAADLHVQMSLAGSAPAALVDAKRWAETPRLKRKARDTRITFPVNAASRAPVLAPPRAVTMPKNTPLEVFNTPGPESVDAIFDYEEYVRLLNGKAGVWVQRFADAMNAPERGGAWQRHSPIPARTRLISQMHLLDSSGVSSLTAHLGDSSGAMALLHEREKASGFYWLLHLALEPIQHKFHIELDKLRQAVEAMQREHAEQVQLIQRALLILQSRTDALLDFLNTFAQQTRHTLSVVTRDVQAQSIIELLSSGALPVAAAETVASFFTPASSAATPNGQPSPSSTPVLQLGTPSLPLVPYPESSQGPTVPHLLRRKWRLKPGVALQAQTQASAMASMNHRLRKAASVKATCSMSDAPTNAAEEVNYYRADLGLSYWSAHPVTSDAQRIFGELQEIAAAIRATRVQQLYAFEENATSGGRPVGRKGRRTAASSRHGDGNHHRCRSPHLLSGDSGNASFFYFRDGSVDGNSVSGPLTTHHRLREGWRTAPASGADGQTAADLLRELAGLRMRRACDQRRLKVVQASLLQGLEKDPVAFMRERAAGGAADPEAEAPHLYFSSSEGVLRTRALQQLRTRTQQRLRGTSQHIAELQKLLDLHCSRYQLESSEDLLAWEVARRIATEGSRGQLRVKGTLNPADQLWSSPYLNDTILDANDQQQQQQQQQRGAYDSHSREELMYLPIGMAGARGAVGNCVAESGRCIMLGSSAISAASLASASMATSKGVEGGNGDAESPAMVARITPFVAVMDYCRGVQLGRPLGRRAGSVYLFQDHASGDYYVGDQAGRNVLKAADDSAGNAAVGMRGEADTQRSLLPMTRILFPAPIRPTAVTTTADVSSAAPSVLASVSATAALHPTYLVPMAIPLSDEEAVIREGWQACHRHGHARCDPIYYMTVAPLPLSKSYHHVVPQPGNSDAVAHGKVVASAAAVAQSVYSGAPMNRYLRSLPCVFQPADEAAAIVRVRAMHLQQRQAANESFPNTAEVDSGPACASSGLPSTGITANLAATATPTLPSLVRPLSGYAPSSPEVHLLDEELLLTADLQESRSTAAAAPLPGSSSSRTAALLALSPSSGLDTRLATTAHDSAPTLAKAVLPASAAAVPATSAFSSTDSSPPLTAALVLAKERRNARLAKEAAHATQAKMMRQKSLRNQSLMRTAPNKEGDVPRAPPHRLFPLSSTHSDSEAPFVLPFPTDSARLQRQIRPEKYSLKPPPPSSRWREVNGGGINAWNLNSDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0T8</accession>
    <name>A0A088S0T8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_343960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702818.1">
        <property type="nucleotide sequence ID" value="XM_010704516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0T8"/>
    <dbReference type="GeneID" id="22578901"/>
    <dbReference type="KEGG" id="lpan:LPMP_343960"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340046900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_343960"/>
    <dbReference type="eggNOG" id="ENOG502S8R7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273840at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="522"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="766"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="931"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="204"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="372"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="777"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="792"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="936"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="950"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="968"/>
            <end position="988"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO02018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1106" mass="120734" checksum="19DB217A5FDA4A7B" modified="2014-11-26" version="1">MSLFAQRERIEVSSGDSEPDSIASTIVDSADELIEGLARMALDGPYSDEPRTYKTSQRLQSRGITRRPHEVALTRPSIELSRQMTPTPRAGSFTPPFYQAPAWLSTQGSAFVPERTGVDVAEAESEARALAKLYRHLDREYFREKSIGDHSDSKPITSGRAERDDYGARARNARSSPTMEATPTHKPRRKPDETARLRLLVPSKTQLARRVEKYEIRKKREEEARQHPKRVRVPAEAVKRGTRLFLEAQERANNVKEVQKEQAKQKAEQEKKECTFHPSVSRYAAQFAAEGAYYPLESRFEDQAAYNEKRMRLRLERAMELEKECTFKPTLSPGTEELMFDLRCRRERFHYCRSFRRPEAGEHTRSRRRRPSPSEREPFEPGERLYRDGGERLLRQQVRLQRAAAKEQRHVVGGALRLSPTGAQQLAGRFTSWAATREANREQLRVALERQERETPKVTVEREAAIRRAGGLRFSRTLSSLGRSTATPRLVQSAANGNGSIAPAVTDASVLPLKNKNYFTSSTGSQRACGDTGNCEASRVPSDRARSSQSPSGADCGVTATNDLRSVASLSAPETCSAVDMPVHKELLRIRLGALFYKYAVSTTATAVTLAQVKQQVRCYYPEDSGIAAALASSFPNGQQHITKIEFMAALARYVAQHGIQPWCLPHHNDPNTIVGAPYSSPASTTTGAAAAVMTNVLVNSAHLPDVMDNDAPGSIPSWTGTGTCGSEPGCRNKVDCSVFTPTTARASEGTSGEKPLRTHIYSSSLPPDCSPPTPAPTAVAPSCAPKGNRATAATTGVRGSTATSRGSLCDGLRDPTASRDTLPANSPIAASEFVRGYADYVQRQRRAIDRARAVSKSPQRNVVEECTFRPTLTPRSVMLSDMNLKKRMAYVRELQLRRRNLQLLHTAVLAEGSGEDGLPRATPSEREFKARDALDSTQTSPLTPSTKHSSASLSGISPPSGLSPSIEVSSLSCSTPQHEGKSASSKPAATLSPPHQQHLAGDSNALRVIARLEQLLNDVAGKEGSIQATESVVRTPPPCSSVNADVSSVGHAGMVIAKDGADTTRTVSTVPLSRFFATKPAQAILCVEEGLLESRHGVKTSRGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S167</accession>
    <name>A0A088S167_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_343350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702761.1">
        <property type="nucleotide sequence ID" value="XM_010704459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S167"/>
    <dbReference type="GeneID" id="22578840"/>
    <dbReference type="KEGG" id="lpan:LPMP_343350"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340040000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_343350"/>
    <dbReference type="eggNOG" id="ENOG502RT2Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="243901at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="426" mass="49418" checksum="9559EAD7F19D9C72" modified="2014-11-26" version="1">MMHFSGVVRRQMRPYYNLPSKSEHGRRMTGFLTPYRHWMWKQNELWRNVHEAQFEHLRKVYKRQWLESFRVNADEYIYKYNITKSAQLAQWEHEMQAQERKRRESQQLAQGRQALKKKHLDLLREFHERQFFYWYERASERLQYMARINYISQASIQEHIERELDKYTVGSKAPYPLNFAGQMPMLEDRDGNIAQVPANLMTNHATENPDGGATIYEPPEGTAVAEEKLLQMMASAQEEELRIRPEDGDAWSESMTDMDRSESARFDSRKVARSMEETDEEREVSRRAYIDRGKTGSKAIFRRPRFDGDGATSPSAGGTTPMKRRKSKTDRMHALQEQQDAAVAKATAKALKDEGSTAGATKRGEVAENRGRLRDRMITPSLETLQQSPEMMAQNKPGGRVRTHHLMEKVYGIGKFKKGGGGDEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1H6</accession>
    <name>A0A088S1H6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphatidylserine decarboxylase</fullName>
            <ecNumber evidence="3">4.1.1.65</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_344450</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Phospholipid metabolism; phosphatidylethanolamine biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="3"/>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702866.1">
        <property type="nucleotide sequence ID" value="XM_010704564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1H6"/>
    <dbReference type="GeneID" id="22578950"/>
    <dbReference type="KEGG" id="lpan:LPMP_344450"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340052500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_344450"/>
    <dbReference type="eggNOG" id="KOG2420">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4330at2759"/>
    <dbReference type="UniPathway" id="UPA00558"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF6">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIO02066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="352" mass="39455" checksum="385BC48760B3ECCA" modified="2014-11-26" version="1">MAPLQLTPPLCFHKNHRNVRLSNPTRRWLYNRIFLGGIGAFGCYLALRYQLAAWEARRHPGDGNYLCSSDMVDFLLYMPLNLISNAAGRLVENQSVPARVHNWFVQAAVYWHALDMSESEQKTNFDTFQQFYVRDWTPTARPVDAAASVVAPCDGQVLAVNTDVESTSLVQVKGLTYGMRSLLQDTLPPLNKDTRRRVAVVLHMRNKDFHHVIAPLSFECEKSVYVPGSLLPATAAGYHWIPSVLTINERLVLKGTSSDKERLPVYMALVGSTLTGRITLYMDKRVRTNYLNPPGYAVHLPYASKPVVARGERLATFNWGSSVVLVMDVPTRCTALKRAGDVVKAGEALFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1P5</accession>
    <name>A0A088S1P5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mitochondrial chaperone, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_040880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="AIN95411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703733.1">
        <property type="nucleotide sequence ID" value="XM_010705431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1P5"/>
    <dbReference type="GeneID" id="22572047"/>
    <dbReference type="KEGG" id="lpan:LPMP_040880"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040016000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_040880"/>
    <dbReference type="eggNOG" id="ENOG502S0HD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268516at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN95411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="148" mass="17264" checksum="E2598AF4891128A6" modified="2014-11-26" version="1">MSLYGARENGGDEMMTPGITGMSGNYRNESNCHRFWNRLMTCMRESQELDVLYDCRSRLLDMRECVVRHKQATWVMRETMTSIRHEAEFRKWLRDYDEKMGHPPLLEAVAAVRKKVDAEGGVDIMNPTVFKDPDMYIPRRNKLASAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1V4</accession>
    <name>A0A088S1V4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_050300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="AIN95471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703793.1">
        <property type="nucleotide sequence ID" value="XM_010705491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1V4"/>
    <dbReference type="GeneID" id="22572108"/>
    <dbReference type="KEGG" id="lpan:LPMP_050300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_050007700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_050300"/>
    <dbReference type="eggNOG" id="ENOG502SJAW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267761at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="676" mass="71818" checksum="354FE53A41B2FBB4" modified="2014-11-26" version="1">MDSATRIPSRVLHLPPPLLQPRGSRWASVQPSPDRASLLLRGRHECQLLAVSSFAQQVPWATALARSSSSGEEDDARHLVAEQWRQRGAARGNSAGEGGGRRCLVLPQPHRDLTSSCWLSASFDTLGDEDDEATVSDEVAFGPVVGLGDAASVITIMRPSPLSTAKSPPGTTAKWLQSTIFLEDAEDAVLASRTPLAWHKQHGRHHDGLDVVTALKRPCHSYRALPIAPAWKAVEAILPCSYAPSHPSGGLTDMYVLCQRVDDVYVGSGIAAAGRSARRPCSCVWLSSVQRESAWRVPLAIPPGDEDTLGIGGDGAAASSLAELRHAVRRTPRLFDVRRRLPRLKHASAHQSSHPRPAPPPALAHERASSAETGPMGLVFAAAFRRHVGLYTSATVTPTVFFVLPPRLTDGVGGRTAAATASPPQWCSNWCVTSVVEDSSFAAATPAAALQTSPVGGGSGYSYLVTLMHNQRSRRRSNTHVAPAKVEHRGQSWQSDANSNSSDCDGNCWWLLYDCRNPSLPVWAAEEALVVPPALDEEVWHDAPVVTEWLASASPPPVSHAGLRRSPLCATYVPLAATSTDDASALTGPSACGVCAVLDGGTTRPGGVALDAENEDVVEGEEATAVFSPIVYELSPPRSLRSPAPGAPPTVTTKLPRVRALAYADGVLHYACEVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S288</accession>
    <name>A0A088S288_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein 45-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_352320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703169.1">
        <property type="nucleotide sequence ID" value="XM_010704867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S288"/>
    <dbReference type="GeneID" id="22579261"/>
    <dbReference type="KEGG" id="lpan:LPMP_352320"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350029300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_352320"/>
    <dbReference type="eggNOG" id="KOG1299">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10266265at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="558" mass="62546" checksum="9C06D13ECB23A942" modified="2014-11-26" version="1">MNCILARDTDMKVLLVDDYALPMIATACSQTELLKHKVYLIESLNSAARQRNLMKMLRCYILLRPRLASVDAACVELRMAKYRSYHIFFCGTATAEMLDRLAHADNDSLVEQVQEVFCDFNAVNNDAFVLETPPPQSLVSSFMSASQVRRLAEGLASLMVAQRRRPYIRYQKNSPFVQRLTAELVEVLKSDTSLYDYPTRDTVLLLLDRSDDPLTPLLTPWTYQAMLHEHIGLRSNTLKLPADVQGAEEEGYVFSEHDDSFFANNMFSNWGDLCNSVKKYVDQCKAALNLDRPTATLEELKDFMQKIPQTKSLTGSVTKHTTVTTYLSSVIKKRNLLEVSLLEQDMIASSDQRNHWARLQSIASSASTSQDDLTRLCLIYHLRYEQPSGASQVTPYLDRVNSNYALLLSKLRQYYGHHRATDRLFAATGVMAKIVKTFVDVGNIYTQHEPVLKRTLQQLYSGQLDTASYPYLEQSTSSSGGGMLNAEYKATEAIVYMCGGYTFEEAALVRSINARTAYKPTDTASFAAGGSSIKASIGGEATLNTHSFLNLLEQLSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2D4</accession>
    <name>A0A088S2D4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase</fullName>
            <ecNumber evidence="5">2.7.8.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">GlcNAc-1-P transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">N-acetylglucosamine-1-phosphate transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">LPMP_354300</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis, transfering GlcNAc-1-P from cytosolic UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol embedded in the cytoplasmic leaflet of the endoplasmic reticulum membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UMP</text>
            <dbReference type="Rhea" id="RHEA:13289"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
            <dbReference type="EC" id="2.7.8.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:13290"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 4 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.15" evidence="5"/>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703363.1">
        <property type="nucleotide sequence ID" value="XM_010705061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2D4"/>
    <dbReference type="GeneID" id="22579458"/>
    <dbReference type="KEGG" id="lpan:LPMP_354300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350051100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_354300"/>
    <dbReference type="eggNOG" id="KOG2788">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262326at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003975">
        <property type="term" value="F:UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06855">
        <property type="entry name" value="GT_GPT_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033895">
        <property type="entry name" value="GPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571:SF0">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="AIO02563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="466" mass="51254" checksum="EFEDEE9D860CAB89" modified="2014-11-26" version="1">MTVGLIESARNACVAVAAHAPVLGLILLGSVVAYVGTTRYTPKVARKLFERDIFGIDINKTTAEQRQQFAARRRAGQTEEKEFQKQAIPESLGILVGAVYLSVVMALMFCLRFLGAVGDGIENVYASLPGPLMTITVMLLLGFVDDVLDVKWRHKIILTTLGSLPLIMTYDGSLSVLMPRVFGRFGLPTMNATKEWLLSLAAAQGEPPTAFRVTAPSTWFSYAVNHCAYVDVSDSGAALVYLGPLYLVYLSMLCIFCTNSINILAGVNGVEVGQSIVIAIASVVYNLCQMRLEGQVTPDWSNTDTAVAAVRDMSSDHQLRALLLLGPFIGASLALWHYNRYPARVFVGDSYTYFAGTVLAVSSITGVYSKTLLLFFAPQVFNFIISLPQLFGIVPCPRHRVPTWNPQTNLLSSSHNYTILNVILYVFGDMHEEKLTWAILKCQTIACVFGFVVRYVLSFLLYDEVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2T6</accession>
    <name>A0A088S2T6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein serine/threonine kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_355420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703473.1">
        <property type="nucleotide sequence ID" value="XM_010705171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2T6"/>
    <dbReference type="GeneID" id="22579570"/>
    <dbReference type="KEGG" id="lpan:LPMP_355420"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350063100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_355420"/>
    <dbReference type="eggNOG" id="ENOG502QTNK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="243443at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1115" mass="120811" checksum="76E041017C5B1B12" modified="2014-11-26" version="1">MASCHASKTAQNIDREPTSQLSLRSYGRQYTRPRRSRSRTETLAVHLGDAEARTYRIEVLQGEASPLQSLLKTYPNCVWDGSAFFLLPLLNEQQEPIDALPSLLTRELPLRGRSPDEESDTAVATGITPPLDFGRETTDEMVLPDMATTFLRSANASFGGAGGTGTLLDTPLPPSLGSASVGGDGSAVKSTSLAAHRAVGMPAASVATTAAPVVPRWKRFSTTAALYLALGEASACDVAHFPYAAVQLCDWDDLVGQQRMRIEAKVSASAAVISALKKGTHRRHDRLVPVAVMFPMSRKGVMRRPFSLTTQPFRDAEVFQLFYLQLLFRAYFDVRFRGMTFTLPGQSAWHLRSDLVAVRSSGRHHVAFEHPTKRDEWLLFPPRTHLLTLLNLEEAVVPLYSTPAELQETSALPLFGAGETLPCVGIAGRKLAQWAATLEVGSPETAFLALVALFDQMKGQFECTRGELWRRATGGPQAGASSFVPLLFRCAECTAGASLRHTGEGLSRFFVPPSERAAASVPVATTTGTHPAGDVLPVSLSSGSPLPCIPVNGSAITTTARDASTASPKSSVTVIRDRLATSATMDSHTKVLSVAVGTDANSDCNQGRAKAFASLLNTVDQAGTRSVRETLCASKSIPPALLHMHSVDAAAGAMSTQSPNAAAVLVSTADAAQAKEAEKTEESPLPVVADAEDVGLGEATMAHGELFNASVGPLSPPTKGGSLVTRWSNYIQTGNCAIFNGPTTDVEVLGFLGRGGSSLVYRGTYGSWRLPVAVKVFVIPDGMDHEQYVRESLTDVAFYVLMNQLEDFGVYCGGRAHDFIVSRQTPKGLPAEAASEVRRGENDARTQLCYLVTDLMDGTLGRFLTEDDADFDPVYDKLLNSALHDGELFQLLFTQLAIKTLFNWKVLDMMLNNQLRGDNIGYRYVAQPLEHASYLKEHPEEAVALSGSRQYYAGILYGFQFGPDEPLHYLRFPAETGTSDHAKLNLLRFIGIIDVGQGMQPNVAELVRKGYIGETVLDSCIEDDGFGRYWPLDELYCRYVDVEGTLAKDVVAWASARCVTTQGDALHALRELFDHFYPTFGVEAPTEAERDTYMCLSWTSTNLANLNAAYVYRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3M7</accession>
    <name>A0A088S3M7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_345210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702940.1">
        <property type="nucleotide sequence ID" value="XM_010704638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3M7"/>
    <dbReference type="GeneID" id="22579026"/>
    <dbReference type="KEGG" id="lpan:LPMP_345210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340060300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_345210"/>
    <dbReference type="eggNOG" id="ENOG502SBYN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272461at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO02140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="260" mass="27584" checksum="E82A0A25356EE85B" modified="2014-11-26" version="1">MRRGSSRLAPAVAARALLSPFGIGISKRIALVGSGNSITALLVKESIPAGTPLLLAPDAALLTCQGALDADVDGLVPPPAEMLEMLKRDTAHLDHVYVAHFLSLQFFTDKGSWFAGQIHHFKDSGSTSKKDAAGSRVWERFAREYVTAPAPVFLAALQYVWESCFRKTATEAACLPPAPLPAALAVAPVVDVAVRSRNTTNSTLTATTAKVVRETYLNGDITGARQALLAKNDAYAYWVLTANTDIPVGSEVSVSPQPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3Q9</accession>
    <name>A0A088S3Q9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_357040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703631.1">
        <property type="nucleotide sequence ID" value="XM_010705329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3Q9"/>
    <dbReference type="GeneID" id="22579732"/>
    <dbReference type="KEGG" id="lpan:LPMP_357040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350080100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_357040"/>
    <dbReference type="eggNOG" id="ENOG502STS8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270288at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO02831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="77" mass="8480" checksum="ED3B3D681A5BEF65" modified="2014-11-26" version="1">MAELQESAWIPTSGDVPAVQKVRDDYMKYLSDVFTNELVELYELDGSNEAVKQLTACLECGVAVYGHPITVDNPSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3X8</accession>
    <name>A0A088S3X8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_351530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703090.1">
        <property type="nucleotide sequence ID" value="XM_010704788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3X8"/>
    <dbReference type="GeneID" id="22579182"/>
    <dbReference type="KEGG" id="lpan:LPMP_351530"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350021100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_351530"/>
    <dbReference type="eggNOG" id="ENOG502QU3H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272582at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="840"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="847"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="862"/>
            <end position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="912" mass="96074" checksum="835812C87CFB38E0" modified="2014-11-26" version="1">MGIPDFVKFIARTSPGALCRVPKGGSRHEPLIFDFILIDATNAAQTLGLDTLRAFLNPNHLSARSAVIFALDSQRDRSGTARAHRHALVGIGDLDVQVQKLCGQLADAYRAREGSNKRLGATAGSSPYVLTSGRGVVGEADYKLLDLQRSLVTCAIASGAAVLPTFLFISEDSDVLCGALCGPAPQQVSIATKLQDVLFEPCILRLDRVLAFVATCTDAFYAENEKEAAAAAKTKMKAMAEDNAAKAMLADSAAAAAAPKSTAERGTDEAMVRRRKQDGPMVATGVRIELADSSDDEQPEDTEKTQAKLMVVSVGATRGALRPALKESSVDDDTCDERASAAPTEGELLVSSIMHTSCVDMVFLFMIVMGNAINVPPLVRGATKVDAGSCWQAYCKLKYRNLPAAEAETGRALLTTSVKTHTTNKGSLVLNCHFLHSVLDAVHYAGAEPRPPVEEEKNNAITYLSNAVYATLRYIVGCNLDRTPALQQTFLDSRPLSESATVLPSLSAVMWVLGQEEMRTFSFPLHGLAKKELLAAASGGILAGKDAAKASARFAPIHATSAREASSSTGDLEVGDHLVAPAASNAWSVSGARPSNISLATLMQNFTSRTEWTSSAPRNGSLTAAAIRPVQLPSVTELVKKSLQKVSPGSLAKGSLLFYLMTVWTYALGLGVRRMATFTKAVTSVAKDDGSVLASTLVQPPALARTAKPLKGASGALPAGGHYVYSFELRRMAPVLQTATVPHPSPITAAPEVSGSAGTESSTALSASGKSAVQQAMFAALGMSFDYSKTPHATGNVMKLPRSALDEDDVGSLQRLKKVAKKKCNVDASVDVAVPIKKHSDDADEVNSATSSTPTSGTMKHGTSKAKKRLGRRERLKQQKTIKKVAAAAASGGAPRHAVCEGVSLPAKTATF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3Z3</accession>
    <name>A0A088S3Z3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_351780</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703115.1">
        <property type="nucleotide sequence ID" value="XM_010704813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3Z3"/>
    <dbReference type="GeneID" id="22579207"/>
    <dbReference type="KEGG" id="lpan:LPMP_351780"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350023800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_351780"/>
    <dbReference type="eggNOG" id="ENOG502SIPY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="296793at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048685">
        <property type="entry name" value="COG3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048320">
        <property type="entry name" value="COG3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007265">
        <property type="entry name" value="COG_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302:SF8">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20671">
        <property type="entry name" value="COG3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04136">
        <property type="entry name" value="COG3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 N-terminal" evidence="10">
        <location>
            <begin position="131"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 C-terminal" evidence="11">
        <location>
            <begin position="457"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="283"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="830"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="924"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="832"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="874"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="897"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="925"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="958"/>
            <end position="972"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIO02315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="980" mass="105126" checksum="1B72AAC59E8861A2" modified="2014-11-26" version="1">MTARSTASDAGEEASLIRQLELLLLPLHHRFRYPLTVPAHLMAGEGGVAAIGANLTRAPLSPALASAAPAGSSGADPAGTMTSHFSGDLAELSEQQQQECLHRSALRVVEEHVPDLLTWQSRVQRGATQAGNCYQVLERVRSSVSAMQRVTEAVQEQSDHLSHNASAMMVRKAKLELVRDALEQNLAHFTRIDDLCREAGNPFLKAGSARFSALLQDIAKEMEFLSTNAQYKSAKPYALKLAAAQQTVSAMLKDAVQTSFRTMELETLASPAFQAATQVLQEGGANPSGSPITEAFTSSSSSPLLMPAPAAPPSSGGTAPTLQLRTHDVAGSFEGFLAAVNDAFVKSGDGFMSLRRMTELRQGGFSYTGAKAFGEERASAGDQLGADPGMREVMDSYCDARVGVVVPLLRYWLTLWYYLDAQQGSLADAKIAGSVAATAAAAAVGAKSLADTGAARQQLSGVAEAHTLPQLAEHICALLQRSLVAELDVLTRLWLKDEVVSQLFPRLAPGIAEEVYYMFRSRLLCVDDVGELSQTVESIQRVSLLQNTGVQDSQVVSDLWVRMIQDTQERLVFRTSVYLRQTVSCCTPTREIASIYLRCGTDAYTTDPAVSTGDDAPKRMFYIPGVVYALRLLDWLYPTLEFSVFSVFAEEAVHHSLDLVRQLMKLMRQIDSSDTLRDSKAFLCQLAHLQHLQVKLSYVDANITVVEKHISLAALRKRRLELEQSSRESKEEVEMDLLKCNECLTTAMFALVTQPVSGAAKKGEAERIRLVSEMKGRAAGMERMIAFYVEYGETQQDLVHLLRNRVAELAAEMNVDVHTVPAAPVKVASSATHAGSSPSKTMTPEALASTTGSATQNSLQLSGAEMTVAPLPPASASRPASTATGGSANPSHAFPHPSTVEAAAESTASAPVELTDATNQAFALPSRAPSAPSGFPSPPTERVTYASALPVATDQQPSAQGYAATAARARSGTHSDTDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S402</accession>
    <name>A0A088S402_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_351880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703125.1">
        <property type="nucleotide sequence ID" value="XM_010704823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S402"/>
    <dbReference type="GeneID" id="22579217"/>
    <dbReference type="KEGG" id="lpan:LPMP_351880"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350024800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_351880"/>
    <dbReference type="eggNOG" id="ENOG502SI24">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266582at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="877" mass="95177" checksum="0B7AD43B5BC4102B" modified="2014-11-26" version="1">MQAEDAAQSPPRKKRGVAAAVPTGRDKMTVAALVSVPPSLSSSFPVPPKSCELHTTAKLRPGSKRGRADKRQSSMDGNCQRSSRHHTETTLEDTAAPASSTPSTRTRTNLTLMYNFESPPLPSPPCRNWQDATASPASLVGSIATPARRNGLVLTSTPPFIREERARAAKGDAATHTPSASVSTPMRLVRVARGLLSPASTTLRRRLTHLRRSAVGASRFGQGLQRQQQTAASSVSPPLSSPWGRLSTIMPASHSFPSCMGEGSYGDNASVKAVSRRSGLASSSEPLSDAVELSSIPANQRFSVSVSDTWRRGGHDAELPELLRPTIQLGSVVLDDSSDDAITTSLSRRSSPTVTAVDEVRGVSRLQRRRRVDDDLRAMSGRGDTAALCGPYDVRFAQVSSLSESLADIVSSSRSTAHSSLTSATATFALGAAGQARISSAGRDGAGDTENECLPRRSATMMDINLSSILPDEEELAIRRRLQRSRNCQAPHAQRDRDIHGANVAALEPVRRHPVATRACASNVMELFVTNAPPLAPLGQQLPLRPEVRRLASSRCASGNSVSGAGGMAAVASEHQSAASHAHTARVWPPEPQHPFTSPMSSVSSWRTVARVSRRTVALLSALVCVWCVVAVVSPLVALQPRYAFSAVARVDSAAAETHFVQIHTNSVAELQALYQIAPASLSADAVMRLHHRTLSEGVERLERATQHLVPDDSAPPLRRLFYLRAMIRAYLVMSRNCELYARSRDGSRWRRYVVYPLADMKRYGVHRFGTFVGSSTLNPGAAAAWRDRVWTTAMCSAQSEVLACPSVLYVEEAMARDAAQFMYTDVNEAYESPQRKRKLKEWRMCLHRDWGSEVYLETLLSYIRSGVQGLTRDYNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S6P9</accession>
    <name>A0A088S6P9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Activator of Hsp90 ATPase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_180200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697854.1">
        <property type="nucleotide sequence ID" value="XM_010699552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S6P9"/>
    <dbReference type="GeneID" id="22573910"/>
    <dbReference type="KEGG" id="lpan:LPMP_180200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180007000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_180200"/>
    <dbReference type="eggNOG" id="KOG2936">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="567237at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08892">
        <property type="entry name" value="SRPBCC_Aha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.15.10.20:FF:000006">
        <property type="entry name" value="Activator of Hsp90 ATPase, N-terminal/Activator of Hsp90 ATPase like protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.20">
        <property type="entry name" value="Activator of Hsp90 ATPase Aha1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036338">
        <property type="entry name" value="Aha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015310">
        <property type="entry name" value="AHSA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="ASHA1/2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13009">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 HSP90 CO-CHAPERONE AHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13009:SF22">
        <property type="entry name" value="LD43819P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09229">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01000">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103111">
        <property type="entry name" value="Activator of Hsp90 ATPase, Aha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Activator of Hsp90 ATPase AHSA1-like N-terminal" evidence="3">
        <location>
            <begin position="29"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN97201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="351" mass="38263" checksum="3A0105BDFE9C4728" modified="2014-11-26" version="1">MAKVGEGDPRWIVSERTDGANVNSWHWEERDLSQHTHDKLKSVFAEHAIPVPADMATSVEYLKIEEVSEISGDVTVAQRKGKMMCYFELKMSLRWVGKMAGADQVIRGKMEVAEVDHDGFKDEYDIAVTCQENDSAAQQLESVVQVAGRPTVRQGIATFFDALFAEYHIGKQLKSGAALPPPPPPLSASASTTLATNAAAGKKSVTPSKSSSGSGDENTSFSWKMRWGAPVVELYAAMTDPSRVSVYTRSPASMDVKAGGLFSFLGGVISGYYVDVQPSTLIKQQWRLSSWPVGVHSSVVLQLVKEEPGVTTLEFTQSGIPAGQLQSVQEGWKANFFEAIKVVFGYSLEYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S9K3</accession>
    <name>A0A088S9K3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF1736 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_220210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699023.1">
        <property type="nucleotide sequence ID" value="XM_010700721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S9K3"/>
    <dbReference type="GeneID" id="22575067"/>
    <dbReference type="KEGG" id="lpan:LPMP_220210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220007300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_220210"/>
    <dbReference type="eggNOG" id="KOG1124">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19588at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052346">
        <property type="entry name" value="O-mannosyl-transferase_TMTC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013618">
        <property type="entry name" value="TMTC_DUF1736"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44227">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44227:SF3">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE TMTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08409">
        <property type="entry name" value="TMTC_DUF1736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="484"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1736" evidence="6">
        <location>
            <begin position="333"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="707"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN98316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="903" mass="101283" checksum="68AA6C3266014ECD" modified="2014-11-26" version="1">MEEGGESYERIMKTPANTLLAAEPAQWPLQCSVDTRIHSFLLLIAGLVFSNGVHAGMAFDDNSAIIANPDTRADKTSLGSIFYNDFWGTPLDHFESNGSYRPITVLTFRIQHWLMGYRHSPAFLHGLNYTVAYLNVCLVFYLARLYVYVVVPRAVLSVENAKAQSCMAVLTTPVHVVPLMAALLYLVHPVHVDAVTSIVGRCELLYCFFGLIGFFGIHRYLNQVDALTSKAAGTPTTHAKKPKGERLHRRAPHKRVFSKLYVLLSVLALAIGILCKDSAVTFTAIYGVHACVMYACGRCQKRHSLTVIVLAVVELLGYLAFRREFIGNIDLRTSPLLSQTEHPQYFVPKGLFHWLSIRWLIQVTNLRLLLFPTSLCNEYSFDCISHVHTMHDPRVPGFLAITGAAVLTLLSLLLGTFAYRSRAALVGLVGFLWMAIPYAPVSHLFVAVGTFIAERCLYVPSIGAVLLITFIVAAPGLREGVVTRYFYTLLLLCVGWGVFSHRRNEDWQSNEHLARAATRSCPNSGKAHFQLAAAVAAREDLVTPEVVALARRSLELDPSSHRGYYHLALYELRVNHDTRKAYEYLRKCMDDLFAYKPCEDLYERVRNTLHPKMTDIEQYADLATIVPRDSYKAVYLRQAGIIALQRDAKPCLAKTLLHSAMTRWNNSKLYWMSDEVSRKAGDVTYCNALYWYEHSVLECEKQSMPGVVDSASADEESEGGDNGADSSSPQPSRRGFPPTPQEAVRRAATAAELFRHCGTDWRSFLAQPRYNYPTIPYRMTSYISVGSYTAAFIAHFINYTASDTPERNAVLLSYLDTTVRLYSHLSTFVHDDYVAEKLGQLFKDQTQAVMRQSSVARRTLLGNLHMPLRELQSASSLSITQTETLQRLLALSPWASELLSFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SCC6</accession>
    <name>A0A088SCC6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_262430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700063.1">
        <property type="nucleotide sequence ID" value="XM_010701761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SCC6"/>
    <dbReference type="GeneID" id="22576146"/>
    <dbReference type="KEGG" id="lpan:LPMP_262430"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260029100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_262430"/>
    <dbReference type="eggNOG" id="ENOG502SACY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272799at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="59497" checksum="DB9ECA33015C756D" modified="2014-11-26" version="1">MGLAWLCDFPPLSLLSPPLSSPSLPAPPRTTIDSIAFCCGCGCGTATVTLPPVSLPPKLPGGDGKHTGARVLCCSTQQPLYILPVFLWVCLLRNVLSPPLLRIMPLHRRAVLLLYATVRRTAAPVGSSSLSATSRAVDESSSPSPPLWRRTVCSTSVTVDGHAAAASAADAPASAALQSNSHHAPLQEPPRRTVHNKEGYNVIGCLRASGHDVVLGRVRVSFTAYILGASVGLLYLLYYLTTYTYVLTTNLSPHRNSLFFHFPCDMAVIENRLTHRRYTIEVVPEAEPPQRLGHGDHGEGGTAGLACPKPAIVERRLHINWLLYRVFLYLQKTESLVMVDTQAEMAPHRFIGGASSVGKASRASVGFLLEDQLFPDINDDRANTTPSQRRWWQWWSRRASASAALLPRPVSGSSDCATTPAAVAATPMAPTKILLKSSVRLRDATNGYQKGHRYTYEQFIHHAAQMKIQQRYYTYVLARGMAKYRGLRKVYAEELIRNGLLSGDGVTLTELVPNAQQFADEIFAEASAKFGDDVVVYEYTATLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SCS8</accession>
    <name>A0A088SCS8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_271360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700223.1">
        <property type="nucleotide sequence ID" value="XM_010701921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SCS8"/>
    <dbReference type="GeneID" id="22576314"/>
    <dbReference type="KEGG" id="lpan:LPMP_271360"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270020600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_271360"/>
    <dbReference type="eggNOG" id="ENOG502RNGX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268991at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="431" mass="50504" checksum="AB7A9917668ABF38" modified="2014-11-26" version="1">MGILTNWYERLAQKKRLELLMTLGMYDERVYEVVERYHLAPDILQTLPSPLTAHFLARGMCYDAVNEEVIRNFIRICMMLSRYRTVEEASTLAELISSCGLPEQYRIQMFNFSETYRHMILSHSYFPQRAVLRLLSYIFCDDFLSDAVAQLQYKSDILNHVNKVYVTTPDFVSWRFSVRCMSLAGGFNEDRSDVEYTELLTRAVSEVLPEFFSYFLITFFYARFRLYPQRVRGITPRWLARQRACFSALYCALLGTYCNSILEYRVHEHRVLYELRKSRELRRRRGAERCGVPYEKNPYFDNLEGVTRHVYTMQLSAYTFTGLGLAVSVLPLTSVKFPKFMGDVAWRHPFVPRLFPALLGMHAASRCLIPFVVAPFTAVSLAKYGNWGTTLYDRYVELRMRLWHRRVDVAFDTSTEVDEVDITGADARKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SDH3</accession>
    <name>A0A088SDH3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_281630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700503.1">
        <property type="nucleotide sequence ID" value="XM_010702201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SDH3"/>
    <dbReference type="GeneID" id="22576608"/>
    <dbReference type="KEGG" id="lpan:LPMP_281630"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280022600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_281630"/>
    <dbReference type="eggNOG" id="ENOG502S75R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272971at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="201"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="300"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="387"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="642" mass="73053" checksum="F965B3870F3D906C" modified="2014-11-26" version="1">MAENEVDAILQNYFATIAEKDSDALKLYEDNKRMRHLVEQTLKAREELEAQLCATQLLVTSLQTDLREKQHLIEAQEKASVVWCDSVAELRSILGRPSEVKQGLCDVVDDVRRMFAELRGLQQSMQYARWCCDEWEAYVLGSLIASETRERRVFEHAAAHSLQALCEAAAEVFNVRMWAAAQKAATGSTIAHWEAWHATTQQEHEKTAEKYAQALRRAEHEARHQARRAEAAHRNAEEMAQLLEAQQHAERVAHELRVVEAEAQVSLVDLLVRRCTAAEGNWCDAVLEVRTVTCRLKNTMEELSGLSQTHEQALVELEQNRLRVSKLSKKVEQFKEQHSELEELQQRCSSQQEELQSLRGKYVAIADKERTLRYQLSTSTECAAAKLLGVEESLQAAERRTAVLEERLRAKQEEARAAQNDVAALRRQVEQHRTTDAVLQATQQQLRATEKHAFNFQEALETLKAEHQEQLQAARDRHATEMAALAEANEDALHSQAAQARARAVEAEERAQRAEETAVREKEALQRELQAWTAEVDTLKSELARGRQCAEAEKTAREVLEQQSRSESSVLRSMVERSFDDARRGPQVAELQTRMKSLQQRNRLLEEACRRSAGVIAQLREALHREQMTSRTLRLTGNSLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SDK5</accession>
    <name>A0A088SDK5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_281980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700538.1">
        <property type="nucleotide sequence ID" value="XM_010702236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SDK5"/>
    <dbReference type="GeneID" id="22576643"/>
    <dbReference type="KEGG" id="lpan:LPMP_281980"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280026300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_281980"/>
    <dbReference type="eggNOG" id="ENOG502S309">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="194386at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF130">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EEF2KMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="637"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="743" mass="79670" checksum="57A66D993FE22D93" modified="2014-11-26" version="1">MEHLPRIAPSLHNVEYTFPWSLILFLQSTPSKNVLSAFQADCESRGVAWCSAEAQKLAVEWFVRHPVVKKYPPRRRMVRALLKAYITSVEEQCAANYALLPTPSEDPVQVELLEEFIRLSVLGDGSEPELCFKTFYNPFVSAPDTPFIPSAPAAPAPPLAGPSMPLSVVPTVANSSPSQAHPVSPDASPHSSLPPEMHTNSAPQSTHPHSEPAHVLSPSSLPPCIVHSDWSEELLPLASVRSPPTSPSKRLPGHHQQPLSLHSPPQTPASDAATTATARVLDQFSAIRVSSEQFSNVGLSLWPAAFVMVQLLTQELEGQTRMLADVLGLPRASSGMSRSESSAPLLTAPNGLHPLTMPASVSPSPLPNRSLCSSSSVTKHYSSQLRIVELGAGACLTPVYLHHMEGYKQHVASFLATDYQEDIVDNMHFNMAENGIHLVSDSLAAERGLEEGDQTPPLHRVALLDWMNHDDNEGLFMENEADVILAADCIYDADVIPALVDTIHLALTARGSALQMADTPQPSSSAKGDGSAATVGTLQRQRCCIVVQTHRQNATMQKFFSAVRTFGEVRSYTLVRQVVGSLRLSEDHSGSDGGCVPLGGWDRETLLLNPDQIVCALMPDVILEDGSMRSVSHRLHNSCTSGEATTAADRSTSYSPPTTPHGTSLDTSGITSAIKGLPTALQSSKSNHSVDSHVSITRSTSSAAALEAVDALLADEMIGPFYTSMAGLIGVHVVTLKPIKVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SDV8</accession>
    <name>A0A088SDV8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_283090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700648.1">
        <property type="nucleotide sequence ID" value="XM_010702346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SDV8"/>
    <dbReference type="GeneID" id="22576754"/>
    <dbReference type="KEGG" id="lpan:LPMP_283090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280037800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_283090"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="140" mass="15235" checksum="E5F43AD846B3E6C6" modified="2014-11-26" version="1">MRHKGWFSKHELQRIALGTLAVYADSDASGISFYSAFSQTAAPMASGAASSERTSIVNQLNPLDVAQQSLGSRKRTDACGTVTAECEAGSFSSMRQWLLWLKATMKWSVIVLFVRRREAQTPVCGEKGSRSGLLGSSVDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SF06</accession>
    <name>A0A088SF06_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_301610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701187.1">
        <property type="nucleotide sequence ID" value="XM_010702885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SF06"/>
    <dbReference type="GeneID" id="22577214"/>
    <dbReference type="KEGG" id="lpan:LPMP_301610"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300020400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_301610"/>
    <dbReference type="eggNOG" id="ENOG502S2M9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272991at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="623"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="677"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="696" mass="77234" checksum="1BE2DD1E896CB3BA" modified="2014-11-26" version="1">MRTTHPLWCIRQCHVALARRSHGGTAQTQRELERLALLEQCMTQPAETRAHQVPAVTAASTAAYLRELPQRVERMRSVAATEDSGECFADRSVAGTSASTALPTEHEESRRPSGEVSAPQVTTLSQFLSACKEHRIQYSSSTDPAPRKQGREVLRSFWSRHASSAVACCYERVRDLGFVADIGLADAGLHLGIRDMRNMLHGLQTERAVASSLDTTRILGYLVRELEYWERRQDNESDRDAAPTPVSLIAFREALTSVALERLASLFVELSPRAENFTPPAVQTATNTPALPGTAFLPGPTSGVDAVWGLEVLAVLHARDATEDVLEDVWNTKQLRLLRQQREPAHLRSGLALPEVSGVTVPISELANEVQYLLVSELFRVVAVRRRDLRMTDIVHAYAMLRVHLRLLWPPYGRQEQLQPSGAARHYSCRSGPVESNGQCAASALAPAPARRRPLWYEKDTLFRITWGLAVALARKDRVFISSYHFVKIVAVLAKLPAFVLSQEPHVKGALRSFELPHRSTAPRRDADEEGEEARFVSATIAAEVMRQEMASEAGSKPTTAVALHPSDFWRFMVAKACVFVPSLPAEQRRIVCRSLHLAITEKRAHLLSLDNGGTVRASRVPRSVRQARSGSTGGRFGSRSVSQDSSGTTFAAEILRPLVEEMEDYPEPYEVCVRDPRLHSPLPRVAPRQQPKGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SF64</accession>
    <name>A0A088SF64_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_302290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701252.1">
        <property type="nucleotide sequence ID" value="XM_010702950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SF64"/>
    <dbReference type="GeneID" id="22577282"/>
    <dbReference type="KEGG" id="lpan:LPMP_302290"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300027200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_302290"/>
    <dbReference type="eggNOG" id="ENOG502SHFK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="262399at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO00452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="353" mass="38634" checksum="8800F5CE0841393A" modified="2014-11-26" version="1">MPSPVAHSAFGADDFKIDSRFLSHMAFLCSPDKPVETSTVVGKYAVSEICVSQAEMADMKMYLDTLRSPGQEQYVSKVAAEMRKAAAKSCNRALAEAADALQEEFSHLKSVFFMRLRSFLVLSVETHKVLGRVVTFPGQISDDYGNNLEEHSENGISPGRVACAHFAESLPTMYIGHSQGSAMAQLCACASGRQAIIFDGATLSELLVHNAVQQKCVRWEPMEDGEKEWHIIHYRTGAFATKQDATVKVTVAAARKIEAEERALQAAAAAEKEAEARAKGEAVNKSAETEGKEVEMWFKKCEWNLIGGIIPQVAQTRFSRTGRYNAKALSDMIVDSTVVMQPAHNPYVCGQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SF69</accession>
    <name>A0A088SF69_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_302340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701257.1">
        <property type="nucleotide sequence ID" value="XM_010702955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SF69"/>
    <dbReference type="GeneID" id="22577287"/>
    <dbReference type="KEGG" id="lpan:LPMP_302340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300027700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_302340"/>
    <dbReference type="eggNOG" id="ENOG502S93W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="251102at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="29"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="223"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="300" mass="33069" checksum="ACC32C924E2649BC" modified="2014-11-26" version="1">MSAHDSSAVVLIARMNDIERQRRLLNMSQREQEAKITFATAEKEQLMQAVTTAGDEEVQLKEDLEVLATEQQQLELQKMEAIDRLRKTQEEEALHTAAVEADLQRLTKEKALWQERAQELESLRRSWEEDEATSACIAALRQESETLALLKVEKTTVEDEVAKTTAAIEKVRAVQPGRLACVDPIGAPAGAVQVAGLARTLASMRDSALSEGNSATVATHDTAAALEEEIKRADYEATQAAARHGRTIAALQREVDALSTRASELQQLFSSIGASWQDVLSRMQELQQCKGSGICRRCLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SI05</accession>
    <name>A0A088SI05_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase M20/M25/M40, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_331700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702262.1">
        <property type="nucleotide sequence ID" value="XM_010703960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SI05"/>
    <dbReference type="GeneID" id="22578323"/>
    <dbReference type="KEGG" id="lpan:LPMP_331700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330023800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_331700"/>
    <dbReference type="eggNOG" id="KOG2276">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7832001at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05682">
        <property type="entry name" value="M20_dipept_dapE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF4">
        <property type="entry name" value="CARNOSINE DIPEPTIDASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO01462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="472" mass="51182" checksum="D9528480A5A26E51" modified="2014-11-26" version="1">MGDCDWTVIQKAVGAEWDASIIPALSAYIEVPNQSPDFDPHWATNGLMEKAFHILIDWVKGQNLLGLSYEFMEVEGRTPFLLVEIAGTERTNNTVLMYGHMDKQPPLRPWAEGLDPHKAVMRDGKLYGRGAADDGYAIFSAITSVSVLQRHGIPHGRVVVVIEACEESGSFDLDYYMAQCKERIGNVDLMVCLDSGSLNYDQLWLTTSLRGVTGGVLNVQTLTEAMHSGVAGGVVPDTFRIARELLDRVEDSKTGTVLLPEAHCEIPDHVAKSMVSMKSVPFKQQFAMADGVSAEPGDNVELALRNFWKPSLTVTGANLPEPQIAGNVIRTLTSLKLSLRLPPLVDSGKATQAMAKLLTTNPPYGAKVWFEPEVPGDGCATPELKPWLSNALNEGSKMAYGNPLAYQGMGGAIPFISTLTKMYPQAQFIVTGVLGPKSNAHGPNEFLHVGYAKGLTLAISHVVAAHFLLAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SIX6</accession>
    <name>A0A088SIX6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nuclear pore complex protein Nup85</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_341450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702572.1">
        <property type="nucleotide sequence ID" value="XM_010704270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SIX6"/>
    <dbReference type="GeneID" id="22578650"/>
    <dbReference type="KEGG" id="lpan:LPMP_341450"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340020500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_341450"/>
    <dbReference type="eggNOG" id="ENOG502RYJN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272090at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO01772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="780" mass="85012" checksum="5BD44F6046220DB1" modified="2014-11-26" version="1">MQHSLQGASLPDALVRAIRAASKAFFQIQASRYAKEANSKSDLGFVSLVMKTKMLGPQVKFDCNHLLPSAWSELYRAAVNELADANATELWGLVSAVLSVIEQGAADCVNASVAIVKWHNLFDNELADAEEVIWRLQREDPHDSLDAVVEEFGSSVLVRIEGAFLTGHFHAAASLIDALLQYLRRGGSALLTAEVETALANVKRLLTVSFHDPVSHRQWVEAANDEVQDSRIIFLHASRGNQSGYDDDSGSGSGGATVIDRLVGDLCATSLDIILIITKDAKWMCERCCDSHHTATAFLTAVCAIVEPYASLERVYSLFGKYVDNWSSNEGSQWYYQCILAVLRVSSVADMVMAMHEVATIAAEALPHAPALPSTLGNEEAYDCDNNDADEDSDTVSLSAITAAAKPPSAATTRRFVLACMAAHIADLCAPSVVATSAAEIHLTFCRNELITAYLRLFALHPRTWRTAGLYACCSPLNDPSFLSEIVLFITPTAAVDERVYRSLRAFFHTTWSTSSDHQQVIRAKLESALPEHATVAKWWSAMEYYYAESYREAHRYIIKTQFTGGNCARAVWLAVQTRLTEVIESEICRQLTNKDALENAQLYMVGSAVQNGLIAIDACTNVELGRYLCAVAALSAYRQAATAANASLAALTPGRPSSFHPSLPSSRKLGFALEAVATCLQTIETALKSLDECHAMVHPSTTFTLVEHGASLLLSLRQLMMDPKTGESNSSAHVSSCLLPLLVESYELASIHNVPRNPRLADRSRALAEQLAHVHQTCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SJ26</accession>
    <name>A0A088SJ26_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Adenine aminohydrolase</fullName>
            <ecNumber evidence="7">3.5.4.2</ecNumber>
            <ecNumber evidence="7">3.5.4.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">AAH</name>
        <name evidence="7" type="ORF">LPMP_342010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.5.4.2" evidence="7"/>
    <dbReference type="EC" id="3.5.4.4" evidence="7"/>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702627.1">
        <property type="nucleotide sequence ID" value="XM_010704325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SJ26"/>
    <dbReference type="GeneID" id="22578706"/>
    <dbReference type="KEGG" id="lpan:LPMP_342010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340026300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_342010"/>
    <dbReference type="eggNOG" id="KOG1097">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000034">
        <property type="term" value="F:adenine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006146">
        <property type="term" value="P:adenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043103">
        <property type="term" value="P:hypoxanthine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000039">
        <property type="entry name" value="Adenine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01962">
        <property type="entry name" value="Adenine_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028892">
        <property type="entry name" value="ADE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01430">
        <property type="entry name" value="aden_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114">
        <property type="entry name" value="ADENINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114:SF6">
        <property type="entry name" value="ADENINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="6">
        <location>
            <begin position="16"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO01827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="361" mass="40684" checksum="5D2A805163F3C05E" modified="2014-11-26" version="1">MMADVALLHHLIEVLPKAELHVHIEGTLSPELLFELAKRNGVQLPYKTVEEVRAAYNFADLQSFLNLYYEGMSVLITEDDFADLAYAYTRTMHESCICHAEPFFDPQGHLSRGITFRVLYDGITKGFRRGEAEFGVSVALIFSFLRHLPEEECLALVRDDMHPDNGQYIRELFAAKAFVAVGLDSSEMSHPPEKFARLYRYCRNELKVPFLVAHAGEEGPPMYVQDAMRMLAVDRIDHGVAAHLDLTLCKDLREKKIPLTVCPTSNVALKVFKDRAACGTVVMDLILKEGLCITINSDDPAYFGGDVRESFRILAETGRLTPATLKQLVLNSFHSSFITEERKRTYEERVEKVFKGVCGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4Q5</accession>
    <name>A0AC62A4Q5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Beta tubulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3320160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="XUY36724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="443" mass="49744" checksum="1E1DE6A6BC45CBBD" modified="2026-01-28" version="1">MREIVSCQAGQCGNQIGSKFWEVIADEHGVDPTGSYQGDSDLQLERMNVYFDESAGGRYVPRAVLMDLEPGTMDSVRAGPYGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELIDSVLDVCRKEAESCDCLQGFQLSHSLGGGTGSGMGTLLISKLREEYPDRIMMTFSVIPSPRVSDTVVEPYNTTLSVHQLVENSDESMCIDNEALYDICFRTLKLTTPTFGDLNHLVAAVMSGVTCCLRFPGQLNSDLRKLAVNLVPFPRLHFFMMGFAPLTSRGSQQYRGLSVAELTQQMFDAKNMMQAADPRHGRYLTASALFRGRMSTKEVDEQMLNVQNKNSSYFIEWIPNNIKSSICDIPPKGLKMSVTFIGNNTCIQEMFRRVGEQFTGMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATVEEEGEYDEEEEAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4S8</accession>
    <name>A0AC62A4S8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3420430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="XUY36807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="738" mass="77305" checksum="CE8483584B8BBD08" modified="2026-01-28" version="1">MNSYRLEVAVKRVSGLNPLIASASSMIAVEVRFLNFPPIMIHPQGYAVGDTVTYNVCHKADFRMCSEQAAANFPAMCQCQLVSVNEGAVAGGARWSCPCLLVPQPGAAAQLSLRTYANYVISNAAGGAVGYADMSCRVLLQDPPSTAPVPISMPAPQASVTPLPVAAPPASALEPSRGTSADQGKPYIVRVVVGESDRHRRPSQATRWDGVQDTSRGHEVTVTRASASDRGQPSRCVSANTAEKGSLLHLLQYDVAYQLQSLSETVAAALHREHDVLTRTPLKGPDKSDALSTSRLTKSIDHHVASIVKVANIVLQVVNQLVDNSPATPRIGASRVVKDMARQMRNPVNKLPLPAEDSIGHYLQYDVLYQLQCLGTNLSYMTVAYRAVLDTPLSSIPVQHVAYCDELGHEIQHLTKQISILVQSCVDGTLSTAALSAAPRPVVQKKDQKQRKANSRSAPQAAAAHLGAHKLSGAAKSFSSTSYSSFSNSRGTSTSSLSSSCLSSSLNRPATPASQPRAPTIVAAPTNPLPAGQSSLAATPTPSAPAQPLPPPPSYATPAATTPRKQTSPSPPTPPPPYTVAAPPAEQTAMSLPTPVGSQMWLSPFNPMDSLGEPTALSQANPLVPRVSHINQANNFQLSTAAPPRDSLHPGSQSTTVYGMTASAFTPQPVLATGGPPALSPQHLSLVPPPLAAPTPLTPPSAAPSPPPMATSKLATPPPIQPQPPVPLTIPIPVPIPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A529</accession>
    <name>A0AC62A529_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">40S ribosomal protein S6, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3420260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="XUY36790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="249" mass="28340" checksum="CB5CC5EC5F2FA43B" modified="2026-01-28" version="1">MKLNIAYPRNGTVKQFEISDEVLRRVQLQDYRLGNEVDGAIFGGEFKGYIFRLRGGSDKDGFPMVPGVLASSRVSLLVKRGAIGFNTFRGYQGERRRKNVRGCVLASDIALVNVTISKVGDQPIEGVTDTTAPRRLGPKRASKIRKLFNLSRTEDVRRYVVRRRVLKSGKKDRLKAPKVQRLMTPKIKARRAKKAKDAIAKVRASAAERREYLRLIASHRRALRQRDHSKKHTHKVHTQRAEVAAFQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A540</accession>
    <name>A0AC62A540_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Beta tubulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3320330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="XUY36741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="443" mass="49744" checksum="1E1DE6A6BC45CBBD" modified="2026-01-28" version="1">MREIVSCQAGQCGNQIGSKFWEVIADEHGVDPTGSYQGDSDLQLERMNVYFDESAGGRYVPRAVLMDLEPGTMDSVRAGPYGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELIDSVLDVCRKEAESCDCLQGFQLSHSLGGGTGSGMGTLLISKLREEYPDRIMMTFSVIPSPRVSDTVVEPYNTTLSVHQLVENSDESMCIDNEALYDICFRTLKLTTPTFGDLNHLVAAVMSGVTCCLRFPGQLNSDLRKLAVNLVPFPRLHFFMMGFAPLTSRGSQQYRGLSVAELTQQMFDAKNMMQAADPRHGRYLTASALFRGRMSTKEVDEQMLNVQNKNSSYFIEWIPNNIKSSICDIPPKGLKMSVTFIGNNTCIQEMFRRVGEQFTGMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATVEEEGEYDEEEEAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5J6</accession>
    <name>A0AC62A5J6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histone H3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1620620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="XUY37073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="66" mass="7238" checksum="D87F239EB5F19D1A" modified="2026-01-28" version="1">MPCARCRACRRRGGPALPEQRDPGDPGGVRCVADGCHEPGQHPREACVTVRPKDVQLAVRLRGERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5R3</accession>
    <name>A0AC62A5R3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histone H2B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1920040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="XUY37125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="111" mass="12387" checksum="CDAAE454AFCD6C72" modified="2026-01-28" version="1">MAVSRHAPRKASRVHKAHRKPKRSWNVYVSRSLKAINSHMSMSHRAMMIMNSYVTDLLERVASEAASIVRVNKKRTLGAREVQTAVRLVLPAELAKHAMAEGTKAVSNASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5V7</accession>
    <name>A0AC62A5V7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Succinyl-coa:3-ketoacid-coenzyme a transferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3020110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="XUY36961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="451" mass="48409" checksum="942FF56E76B543BD" modified="2026-01-28" version="1">MGTKQLTLIAGTTSGPENGTGPLARDRQIAKVITSYVGENSVLAERLLNGEFEIEFCPMGTLVDRLRAAGAGLPAFYTPTGYGTAVSEGRLPVRFVPGNPMRVAEYSHPRETRQFGGRWCTLETALPADFALVRAWKADKRGNLVFRGTTQNFNLACAKASKVCIAEVEEIVECGELDPKTVHLPGVYVHRLVCPPSIRRAAEFVVERKAGLSSGTGKDALAARNIIARRAALEIKDGMTLNLGIGIPNLVVNYIPHEMDVVLQGENGLLGIGPYPLPEEVDPDVTNAGKQTVTMSKSGASLFDSAESFSMIRGGHLDLTMLGALQVSSSGDIASWWVPGKVLKGMGGAMDLVMSGCRNVVLMEHTNKEGKPRVVQSCNIPLTGAGVVDLLITELCAFRFEKQKGGVRVMWLSELAEGVTVEQVKAKTMASFKVDPNIKTMPLAPVPVPHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5W3</accession>
    <name>A0AC62A5W3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tuzin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2020010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="509" mass="57329" checksum="E4E522A4E7E59EED" modified="2026-01-28" version="1">MEGAPVSAVAEVSTRVHVQVGRTATNEGRVVGGIVGRVNSNGTLGVLMDKSCFAAQVSQDDLVLVEGRARITLERGYLDMVKWIRDAGVHRRADRERLSSVLYQRGWRVDRLYLLGPSDVHCVSYVKRSVRLLVLERAEWQRDHHAELRALQRERVRERAWRYAIQRYSGFVSANWAALGVLSVLLWNFKGCRRHQRTFQVKRAVSTLTDTDQQYTSSPAEPPPFVERAAEESWARQVLRQPDITHPRIAVVTGLRGCGKSSLLRSAARKEHRPALFVEVRGGEDTLSCIVKAMKVPNLECCGDHLEFIADTFTKAAKVHGERPILALTRREGCELSRVYNESALLASDRRLCHLAYEVALESLTTQNVLLPRLDFYSVPNFTARQALQCTEHAVDATSMLHFLEVMGTHRSDIDELLAAVRHRGVSVVDYIDQRLLRAMRRAEAAWASSGTLRAAVKRLAEAEYCVGQQNGPGVLRGAELKGIVLYDPVRDRWMFTHKVYHTAARCCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A612</accession>
    <name>A0AC62A612_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amastin-like surface protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2020870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="194" mass="22191" checksum="6A5C0B5FCE518DDD" modified="2026-01-28" version="1">MEFNPFIIVYAAIQFIAFLLVVVGTALDMFRLQSRENFEDRPCITLWGLKPYCNSIVYSLSSDERFSLCPVRRKRFHMAQILAVVSVGVYGTAFALGVIMLYCCLHLRWVCLLLNIVGFVILPIPLALMVLSYKTDENSLCPKLRDDYDFGVGFYIFATAVGMDFIDIVFLLIPWQYDYLDVTCNSKEGNSQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6A0</accession>
    <name>A0AC62A6A0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amastin-like surface protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2020630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="192" mass="21476" checksum="80FE57CF4580DA15" modified="2026-01-28" version="1">MEWSIALLVYVVLQFIAFLLVLVATPLDMFRFKPQVPNFRGCLTLWGFTNSCGSVLYNGTVYDVWDECPRHLMRFHAAEAFAIISIFVYGTAFVLGVIMLFCCSILRWVCLGLNILGAITACIVWATMVVIYFNGEGNDCPPLRRLTHYGAGFGLFVAAWVLNLINIFVLLLSICTPVTTESNQVEQTEGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6D6</accession>
    <name>A0AC62A6D6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amastin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2020440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="218" mass="24256" checksum="CCC1F440C593F04A" modified="2026-01-28" version="1">MEWNVPILIYAIVQFIAFVLVLFGTPIDMYRFRPRFITPDTTVTTLWGVKKGGFNSTNVISSDYLWRRCIVRRDRFRLAQAFAVISIFVYGAAAALGFIMLYCCSFFRMVCLALNIVGAVTLCIVWAAVAVTYHIEDNEFCRKESVFSTYGAGFVLLLLAWLLDLFNIVVLLLPISIAAGGAGGSSSKDSKKQDESSNDHSRESSMEGSRQNDLSEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RGV8</accession>
    <name>A0A088RGV8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sister chromatid cohesion protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_010720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009370">
        <property type="protein sequence ID" value="AIN95172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696714.1">
        <property type="nucleotide sequence ID" value="XM_010698412.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22571801"/>
    <dbReference type="KEGG" id="lpan:LPMP_010720"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_010011100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_010720"/>
    <dbReference type="eggNOG" id="ENOG502QT9E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273712at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001838939" description="Sister chromatid cohesion protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="651"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="843"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1444"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1537"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1460"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1537"/>
            <end position="1557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1589" mass="167319" checksum="C32E33AFDED95A7F" modified="2014-11-26" version="1">MPVAPLLLVASSLIGLSSSRSAHATGSAEAGPSATALRASAGRHALSSTTIFDLRGAGVSTASLQPGVRRCYATTATTSTQASTPTATPSAAGSVSASWRSKQPRHHQVIDLGNSLSVVVPVVGRSPTPSSPRHHRDNRRHHSHTRSKATRRHRHSAPHVSTSDGRTEASAADGAVRVHSQHESKQTPQARTHPRQATSSLLLPSPHQQQHDTQGALETNQKGLLRIPHTAAEAVALLECSTVLEALEASSLSHVPPHSATPAAGADNVRANFEELQNRALPLLFHLAQTAATPSAPGAAGEVVAATNAELATALECLATHLQHIAAAARTDGRRHVSALPPAVVVALWVQVMPYVHRCVHKGEASPPPLQPKLEEMDGGAHECAGEAETSVLGDVEDATTELRNGTDALTSSTAASKTLAVSANSVKKSAYVSLRRAISLHTRRIASLLPPPALALVLTRMYHCGALADDILGPIVADHIEALRRSASDHATSHGNSIAALRQRVLRLPDGDGRDAAPPVAGFTGAAAVTMARLLGRAATPGHHQLHRFFHLALLPEVTRVLACAAERAVQSAADEATGEAAEVPPGADALLDLTAALRHYAVSGHAVTHLTTLWVMHFADRQCQGDAAAALFVECAALLRAVSSAPSASNRTQRRRARHISPDGSHGGLSATQQRRRLLEVTEGDYYPLVDVACAQVCRLCSHAQSCADTSNTAALASTQLLALLCLLTRVNSPHWAETYEALASAALAALTCAAASLAAAAAPSRSEEEVLEQLLPLTDARRTLHALLHRDSLIPDHPLHRVLLRRLLYSPAAMTDTAVASQVLLGLELMVPVEVRSAHADEGSATTAAPAVTDDSSRSNDALTAATAALNPSADPTEALVTATLGTAAKRLLSTVVITPDDRHRALQVFRRLGRSIKPTAFMAGLCVVPLDTLPHTAQVAVVNHLTSVASAVSPSYLVKGMEAVVRQLPSSVVDDVSVQHWFSRFTARDVARRIDPVGCAVLLNILSSNPRYQRNCALAKECITRRIGVALRQTGEDGASGAVAGAVSLETLPYVVTSLQRANVFLPQYYSRACRLLLGQVEQASLGEILESFAVVAEAYMNRQRSEAQASVFKDVWELLRGRVMEEARRLTARETLTAINAFAALDVTDKALFGVLVYQLWACLRTAEAAVADAAATTSDGAEAAEAHVRRRVQAAQHVLRALTPSAVAVVTTVLFARSDARASGAAQAHVATAVGGVGKGEDEDGNLVCSLLPWMLLALRDCHTELYPVDVLHLMPSLLEHYAAAAAAAVEDPSAPSGHGDRHAELLHAAYDACRNTFLLMYALLPDTVTATQQPLLPVAEQQRIAEQRAQWTPATKLSVEVVPRPWFASLLVSLSSAALLDDAVALACVRRACTRRVCGSLLPISQLVDVCLSLCWLTTSTGLSATTNAASASATAHSNKGAQAPATPPVTCADDLSSSSPSSALPTPGTVLRSAMATVLSALWKRSDELTSAQISALLRCLRDTYGAEKVDADFVERLEAQKALLLVQGQQMRSSAAPTSSLSEARASNGSGGVASDVSSPHQQKPKPVAQVDAEDLFSTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RGZ0</accession>
    <name>A0A088RGZ0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_020470</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009371">
        <property type="protein sequence ID" value="AIN95227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698192.1">
        <property type="nucleotide sequence ID" value="XM_010699890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RGZ0"/>
    <dbReference type="GeneID" id="22571857"/>
    <dbReference type="KEGG" id="lpan:LPMP_020470"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_020009800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_020470"/>
    <dbReference type="eggNOG" id="KOG0548">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001247">
        <property type="entry name" value="TPR repeat/Tetratricopeptide repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF534">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="228"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="20"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="89"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="296"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="399"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="402"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN95227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="522" mass="55492" checksum="130BA41A3C32B672" modified="2014-11-26" version="1">MSTAADRQAFLRLMGLTDADIADPDQQPGAMPHSQTSSSNYVTGKAQRGATYNSPTVSSVTGLSHSASLGGYSTRPSLMTTANTLRNTSLISASGPPSSSRTLFSTPRSVHWEEEHTATTSPASQPPQQVGTSGCTAAAISEELKENGNCAFEAGAFCEAVQHYTSAINALAASPTHSDAEVMLLAALYSNRSAAYLQAAHELPSAEDAYAHALCDADRTVALRLSWFKGYARQGDTYFKLKQYGAAAEAYEMALQLDPPNHALMNALAESRQRAKQVAREELELRRIMLSTTSTTPSLVSTMTGQSGESTRCEGDPRRGAAASQRVQTPHDVYDGGRRRSGQAQQLWAELKREVEATAHEVTGDAYRLQQLERFRVRNSKEATPTACQTAERNTYAKHAAVSSTGAPSSAPMQGKSVAGPRVGAGSRLDANTGTAAAAAERCHVASASPFSAMVLSSESQLPPRRRFSDSPTAGGIAAAMTTFNGPVQSARDVPYEFSSAAASAYQQHLLEVFRQRKAASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHD5</accession>
    <name>A0A088RHD5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_040680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="AIN95392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703714.1">
        <property type="nucleotide sequence ID" value="XM_010705412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHD5"/>
    <dbReference type="GeneID" id="22572027"/>
    <dbReference type="KEGG" id="lpan:LPMP_040680"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040015500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_040680"/>
    <dbReference type="eggNOG" id="ENOG502SHEF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267413at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="670" mass="69652" checksum="632465A151FF0F5F" modified="2014-11-26" version="1">MGSHASATAPMADFHMTVDEQQQLLNNAPIHNSLARPDSGDHINDHAHHGTQYMTPLSSPRGEDPADKTTASLAIHGTSEPAPASAVAAVEAPSPGRAALSSLSCPDHYRRRLFASSRHDLDNTVEEFVQRAANDADVPPGLLGFLQRQRQHQPQEQLRQDPQPGLSPLVSTSSVNSVRSVAQTTPPRQSFALPSQDLDSTAACKAATAPMEVNRDDSDVLLHSHNSSGSGGTQVYGLTKLAPSDPSSGLAEEDEEEGTTFSVGGGGGGNGHVRPRLTAGMKTARLLAAPLPKQRHCSSHRMTAPSVNPQSTRELRQLCTSALQRRDSTITGVYQGISSGGGAAASTARCDSTASLMRLQRSHQPVPCTATVSGVTLPVVFRFLAIRSCSQPDSVPRVLPASDSSPLPTTSGNTGRALADHLYEVPGVLRQRVHPPALSTSVIAFPASLAQSSPRGIDTSAGKRFALADVQKPTQVADEKASKGHSCVPLPPLLQLSSVATRASTQSSASAQLFGGATATNATILSSISITDIPSTNLSSSVAAACGRQAPTSDYATRESYSSLGVSYHQQPRFRRAQLGSVSSHSRSAVKPPTAEAAAAAAAGLSDIVTAGSISGRRSSYGETDPSLTAGVVWFGMFSSYAPSVTSPTADTPTSTTNYCYSCASSSIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHQ8</accession>
    <name>A0A088RHQ8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_030700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009372">
        <property type="protein sequence ID" value="AIN95305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701013.1">
        <property type="nucleotide sequence ID" value="XM_010702711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHQ8"/>
    <dbReference type="GeneID" id="22571936"/>
    <dbReference type="KEGG" id="lpan:LPMP_030700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_030011600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_030700"/>
    <dbReference type="eggNOG" id="ENOG502RY0D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6079689at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050891">
        <property type="entry name" value="TatD-type_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060">
        <property type="entry name" value="TATD FAMILY DEOXYRIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060:SF47">
        <property type="entry name" value="TATD RELATED DNASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="487"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="551"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="490"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="551"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="591"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="633"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="719"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="747"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="772" mass="82726" checksum="5E5220681522ACDE" modified="2014-11-26" version="1">MGFVDRGGGREAKGSSLRRSKKNPGAPTTKNKSASKSYTTPTTRSTPMPPPVCLPVLKALIAPTASEGTAAKATAASTVAGYEKALAAVHAAAQAGGSLHIDAAVALLSRKLKEDQEGIFRRAVEEGKLAAMVCWCGEVERQSLLLDTCAQHNKLYRGALEQQQEQYSTTGSDVRHVHFKNDYTAPPGAVVASITTEAMASPSSAKAGVTLYAVLGIHVNNIDRLNIQLHGQWVKELERNVKHSDVVGVLTGLNLSRDHGTHYAQERLFKECWRVAAEVHLPLVLHLYAVDAASLTETVSHAAKLLDELLAAGAAPSAVVLYDALRVLHSSTAMRKLLRAHHPAAETTAGVAAVPFYALVTADGLALMKEEDGEAEGTTAAESGPSAEALAALLPPRAQIASSAAVHLSQLLIGTGAPWGTPQNLPDPHLRTLPNEPGNYTYVLQTLYDTMQAPTAVAALTLAELSAIVVVNHLRVFLHECIVAPPPPQQQQQSSSGDTTTTDAAQQQQRQWDESQQPGAVAGLEDSDAKRDLEALLVEAAKERERLVQERLREEEAREQARSEELQEKRSKREKKKNVKANNRSNFTHFRNKDFAPRQSKQERLTHLREVGSREESDADVDGKEDAREKALSSTSASSESDSNSGDGAAGPNSLAAEVERLLQANAAHCDQKSVAQRQPAEGAKGKGKKALPGSGKAHSTANTKEGQQHGAGAGGNVENESLDNSSDTGEAQDPTGPTMVRAKMQISRRQRKRQQKRQQQHRGDDSSDDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIF6</accession>
    <name>A0A088RIF6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">5'-3' exoribonuclease 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LPMP_060240</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703907.1">
        <property type="nucleotide sequence ID" value="XM_010705605.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22572230"/>
    <dbReference type="KEGG" id="lpan:LPMP_060240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060007900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_060240"/>
    <dbReference type="eggNOG" id="KOG2045">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="372487at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000005">
        <property type="entry name" value="5'-3' exoribonuclease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041385">
        <property type="entry name" value="SH3_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040992">
        <property type="entry name" value="XRN1_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047007">
        <property type="entry name" value="XRN1_D1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047008">
        <property type="entry name" value="XRN1_SH3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF75">
        <property type="entry name" value="EXONUCLEASE XRNA, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18129">
        <property type="entry name" value="SH3_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18332">
        <property type="entry name" value="XRN1_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 17" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="Xrn1 N-terminal" evidence="13">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="14">
        <location>
            <begin position="291"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="14">
        <location>
            <begin position="406"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 D1" evidence="16">
        <location>
            <begin position="620"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 SH3-like" evidence="15">
        <location>
            <begin position="1128"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1201"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1274"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1370"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1207"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1374"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1427"/>
            <end position="1442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF18332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AIN95585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1513" mass="168722" checksum="E07AB15574A99EBE" modified="2014-11-26" version="1">MGVPKFFRWAAERFPSIITPFKDSPPPVDNLYLDINGIIHNCTHPNDVDATRRSPTEKEMIQAMFIYLEKLFNAIQPRKYFLLAVDGVAPRAKMNQQRQRRYRAGYEMMVAREEALAMGEEVPEEKDMFDSNCITPGTPFMVRVSTEFQYFITMKLSTDPAWQRCEIIFSGHDCPGEGEHKIVDFIRRRKMQPNYDPNETHCMYGLDADLVMLALATHEPHFVLLREVVTFGPGSRKERERQEEDEAKGLVKDKAYHKADEFVLLHISVFRDYLQLEVKDYLAKAKSNTNIDFERIVDDFVFMCFFIGNDFLPTLPTIGINDGSIPVLLRLYVDNLLSKNRYLTHKGEIDWRNAEVWLNEVGRLEFETLRRRQQEEAEYQKNRARRDPTHEVDTTSAMPITSILEFKQRYYGEKHGFVGGWDANSEDMRRLREHYVEGLMWVMHYYYQGVPSWKWFFPHYYAPMASDLVNLPGISARVTFEVGKPFQPHQQLLAVLPPMSYLSMPKAYWPLLRSPSSPLAKYLPEHIVIDREGARAPWEGIVLIPFIDERTLLAAYESVQQNVSPEDAANNVNGPPLRFRYDGKMTPYELEDQMFGSLRNVFVRRETYAFPPIDKFIPQLCPGVHVGTQQLEGFSTLQSKRDLIQTIFEAGVVTIFGRPTKNDSLILQMRDFFKAKSIDQVATLVGKEVLVGFPHYKRARVACVKDVHKCITALYSKEGTFSGTEEHKNNRDESAAFLREAETHARFMKSQLGLAVEQVHALVYVHRFNGMQVTRKGHIERHFSTTWTCYPIHLICTLESIDMKEDSRYVERYRSEGDSAFGARCVYIGPQPKSKKSQVDVYGCCGTVLTTGQHDTATQQGDQLTVRLKVFQEPLRLPEELLQFSALRNWTALPQVAASLDILPHTLTSICSSLVTSPQFGSRELGLCLKFSGRCIAKVGYAKLVQHNFNPWYVGNKDIFSRMEKDTEDIGYHLEMGEKGDFAGNSSNNRGGSGTWYFSRDAQELIHDYVKRFRPLIQYIEAGGVNSRSLEPQQFLTGKWRDKDAAEVLTDIETFLIESGLRETPMITATEEAFPQQLLEQLEMSLQEQQSRSFKELSLRQVSRNQLYFPVTYSSSGHLVPLPLPKEQTFSLGSRVTNCRATGTVPFGMQGTIVRLLASGREAEVVYDTPFTGGTRLDGRLKDTRAAITKLSALLVLKSTDAPQPQPEAQAQPQSQPDMRAASTASTDGSARLRELEFLLQANGIHIDPSGKSTGSPPSLPAAFQNPAATAARAGLADSGASHSLTAGASASVVPRPRSAAAPEQTPASATPGKRSTPASATAHLFSSASSLASATGESHTSPASLKITAAPGSSGISLQDLAKHLPTSTSQLSPVRVASPASHAPASTAVAATTTTAPTGITIPAPKSAQQHQHSPQPVLPPLPAPATAAAASVGAASLHPSNESKEASPGLTTRPKPRNLHVIPGDFLSGQFKIKYTNTGSLFRSWLNTFTAEAVSKTLAELEAGENANPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJ04</accession>
    <name>A0A088RJ04_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA polymerase</fullName>
            <ecNumber evidence="8">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_080750</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DNA polymerase type-X family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="8"/>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="AIN95883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704205.1">
        <property type="nucleotide sequence ID" value="XM_010705903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJ04"/>
    <dbReference type="GeneID" id="22572537"/>
    <dbReference type="KEGG" id="lpan:LPMP_080750"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000033900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_080750"/>
    <dbReference type="eggNOG" id="KOG2534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="205514at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00141">
        <property type="entry name" value="NT_POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.110:FF:000008">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000059">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.210.10:FF:000007">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000042">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.210.10">
        <property type="entry name" value="DNA polymerase, thumb domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002054">
        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028207">
        <property type="entry name" value="DNA_pol_B_palm_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018944">
        <property type="entry name" value="DNA_pol_lambd_fingers_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022312">
        <property type="entry name" value="DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002008">
        <property type="entry name" value="DNA_pol_X_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
        <property type="entry name" value="PolB_thumb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276:SF14">
        <property type="entry name" value="DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14792">
        <property type="entry name" value="DNA_pol_B_palm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14791">
        <property type="entry name" value="DNA_pol_B_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10391">
        <property type="entry name" value="DNA_pol_lambd_f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00869">
        <property type="entry name" value="DNAPOLX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00870">
        <property type="entry name" value="DNAPOLXBETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00483">
        <property type="entry name" value="POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81585">
        <property type="entry name" value="PsbU/PolX domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 8" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="2 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase X" evidence="9">
        <location>
            <begin position="10"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; Schiff-base intermediate with DNA; for 5'-dRP lyase activity" evidence="7">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR622312-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN95883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="376" mass="42728" checksum="A2D4435C109797B9" modified="2014-11-26" version="1">MLRWTFLRRDHRENIIRIFQEMADLNNALGEKYKVSSYHRSIESLKTNLDKPLNTPQDLKAFSGIGAKLLKKAEEIMATGKLEELESKTKPKLKAIQELTQVHGFGPRAAAALFDREGIFTVDELLQKADSISSLTDQQRVGIKYFYDINEKIPMQESVLHENYLREKCMEVLGKDFSILICGSYRRRHPFSGDVDAILSRTLDAPPLNEPVAATGVLAHFVEFLESIKYLEATMAQGPLKYMGMGRLPPRIVRDKVGRENTKVYKARRVDIRLIETKSVPTAMLTFTGSKNFNVIMRQAAISKGYLLNEYGLFKLGTPEEARALYERIGIRGKNAGEELGVPKDELEDKRVEVRSEQDVFDVLGMPYAKPENRDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJ19</accession>
    <name>A0A088RJ19_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Exocyst complex component 1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_080950</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="AIN95903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704225.1">
        <property type="nucleotide sequence ID" value="XM_010705923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJ19"/>
    <dbReference type="GeneID" id="22572557"/>
    <dbReference type="KEGG" id="lpan:LPMP_080950"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_080012500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_080950"/>
    <dbReference type="eggNOG" id="ENOG502RUJ0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276486at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019160">
        <property type="entry name" value="Sec3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092:SF14">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092">
        <property type="entry name" value="SEC3/SYNTAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09763">
        <property type="entry name" value="Sec3_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exocyst complex component Sec3 coiled-coil" evidence="3">
        <location>
            <begin position="197"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="633"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="720"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="225"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="641"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN95903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1144" mass="127215" checksum="D1139B214EDCBBA3" modified="2014-11-26" version="1">MNRYRELQPTIDGIFHQRGEEVVAHETVSEIGNKKKASTPRLLILSHFLGSSGSATLSIVTVNPSRQRVKLKSAFAVDRLISISNEGSFDAAFNFGSSGVLSVSFESHIQREMFLAAARRILAMPSSSSGAHGGYAENRMSPIHGVLTEAVGAQVEADAAARVRKLRQDKRRVFTTEEEKHLLRHIGNNGAGFDDIKQFQEILLRQQKNSELRSLNLLTTSEAAWQEAQRQVQDLVQDVEEVEQRIESYSKHLLSKKAVLQQVEHTNNTLQRRQQNLEALYMMMSDLRDQLRLAPATMTLLSRLRTIPEDCLVAFFSEGSNAVTLSMAMKHMQSVLHNPKLDSDFPIAAVAERKVFFLEQRKMIAQRSKLYIMAIIESFEAKYLADKARYSRDALLVWQLHVELAHKLIDISGVICALECIDVEGFNNVLRKYRTSMQKVYALEITHFFKCLKKQVKKVNTWRGPFLLGTSESRREAMSMRMETAQSGETPRMYSRYGQSTPALTPRMMRFGDDSDQGASAGGWTASGTGGNEDHTHLSVQFPSAADLSMEGGVPASAIQLYQSANTLRRLDSRAEVSSVVSGIKSLSPTSTSGGGYVRPDLAFAIALESSVLAVINEEAILHRCFNLFSTPEEKSGNDHSAAGSSSTGASPQADDSKRTGAATLRGAAGTDRAQMKQESLLELFGGVDANYFVRALQGMSRSDSAQYSCSNSQDIGLPPRPPPAGYGGGSWGQGNSSFPHRRTWSGTSSAVYDRERNSIAGDEVDGGGPDDEASRASRIALHRNFLIRTMRDLALFVVEKCDRIYCVPILCMIRAYRATAADSAMLPSKSAFCQAMLGEVEAVMVGGMTRFVAEQTDSIHRCRKRYVVHPTPLLHCFSKMPALFLRLEAVHNALAPNVCDRTEYASIALSLVDQSFDALDQITNVRGTGEDRNAGHLKLNELIAQKLHSVLDGVEADISSLKWVFVQQYRHQSFFCAFYSTMPSDSFAVELLQDHYASAKAKRDRYEELYLTRVLLVRSFPVFGIFALSAEDLSMIYSKEELRHHKALSVDAVEKVLSGLEKEMRSGVRASAERMKRHFLRDVDLGGNEASFHTTLLQRTWQHFSTLLLRKFDFLAELLSWPAYRDIFIPITRSDVVGMLAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJ88</accession>
    <name>A0A088RJ88_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">N-glycan processing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_090620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN95978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704300.1">
        <property type="nucleotide sequence ID" value="XM_010705998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJ88"/>
    <dbReference type="GeneID" id="22572632"/>
    <dbReference type="KEGG" id="lpan:LPMP_090620"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090011400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_090620"/>
    <dbReference type="eggNOG" id="ENOG502RYPE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28322at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017177">
        <property type="term" value="C:glucosidase II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039794">
        <property type="entry name" value="Gtb1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630:SF1">
        <property type="entry name" value="GLUCOSIDASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630">
        <property type="entry name" value="N-LINKED OLIGOSACCHARIDE PROCESSING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN95978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="713" mass="79003" checksum="394C88651E3B880E" modified="2014-11-26" version="1">MSTPPPLFSCGTRVVDLRSEGRPEVLAACQAGLGVAWRHAGSADSNRESDSLFPTLRVVLTPREVRWHSDVQPVNVVSQRIPLSRVNDDYCDCLDGTDELLTNACSMSGPLTPAAGTRWKSYLISNQQLRLWEADDVIAQEDAEARGYPLQRRKHGDVGDRLYVSTGPVLPFVCTCGTVTQLLAPSLVGDGIVDCCAAEDEVVLQGTPYDGASPHRLSGDPAIVEANDRALEAARAAMLVLWKERRVSASQYKIATPSTYEDRLYPHHTSARAMLVDKGYYSLYTSLEVQQEKQAAAAVLEGIYAHGHQIQRDRVERGWDQLGRHLVDNRTQLQLQLSNVTRELESLEEYVRYRMGEARTNDPLAAGVPMHHLQHHARLMHMHDVLTSEVQHISLTTLHRAYGDHYEYYPLARRIMHLEASHLVDPSTSTTLDPATALQREARIITPTEVERRNTAAYAAQQPPPPLHVDNISVSDYGLEVMHQVFVAQRFDSREAPLVAQRLGLLPSHDISAYTPDIFNRTTSPFQRAPVIPIGSWQPYQSHRNSRVMVIADPAGDVHLARRACVTPASTLFRGGGRLQWPTRYPEAPHAVSVADAEEVKKTPKDKLKAASAGETAKVSQRYIPHHTNTPSVFAVDMYTGGIHCEPDRLQGPGRTLQIHVAYLCDPEDGILHWAKNGKCLQEVVIGTPSACTAWAWKVATSRLKEVGKAAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJA5</accession>
    <name>A0A088RJA5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.205</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">2'-O-ribose RNA methyltransferase TRM7 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_020290</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine = 2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42396"/>
            <dbReference type="Rhea" id="RHEA-COMP:10246"/>
            <dbReference type="Rhea" id="RHEA-COMP:10247"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74445"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.205"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.205" evidence="7"/>
    <dbReference type="EMBL" id="CP009371">
        <property type="protein sequence ID" value="AIN95209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698174.1">
        <property type="nucleotide sequence ID" value="XM_010699872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJA5"/>
    <dbReference type="GeneID" id="22571839"/>
    <dbReference type="KEGG" id="lpan:LPMP_020290"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000014900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_020290"/>
    <dbReference type="eggNOG" id="KOG1099">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="289250at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106340">
        <property type="term" value="F:tRNA (guanosine(34)-2'-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002128">
        <property type="term" value="P:tRNA nucleoside ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03162">
        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028590">
        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF12">
        <property type="entry name" value="TRNA (CYTIDINE(32)_GUANOSINE(34)-2'-O)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="9">
        <location>
            <begin position="21"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="127"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="284"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="420"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="447"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN95209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="459" mass="48313" checksum="B280F4F9761072E7" modified="2014-11-26" version="1">MGRASKDKRDIYYRKAKEEGYRARSAYKLLQIEEEFHILDPAEIRTGAVDLCAAPGSWSQVLAQCFKTIGANATAAAVAGAALPAQTPRVVAVDLQEMAPIDGVAILQGDITSEVTANEIIRLLNAPNSTGGPYTDDEQQQQQPTSSNPPSSSSSSHPPVLCASQRKADIVLCDGAPDVTGMHELDEYLQHHLLLAALHITTFVLRAGGCFLTKMFRGPNTAFLIAKSEIFFEQVRVVKPKSSRNASMESFLLCQGFRMPPGYVPRLISAAPASAVSTVSGGSASASAGYGSRAEAENEEDMKGGRRERATVSGGRLRASGFTPEAPSYCYGTTASSSHVPAGNAAAAAGQGVALDSQRTSCTLAERVLAPFLSCGDLSGFDADMCYDRDEEVGVLEPVQPPLQAPYLAAAAASLSLSAEVAGGQDTRGAGVPQSKKLRVESQVGAVEDDPNASEEQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJA9</accession>
    <name>A0A088RJA9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_091540</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ropporin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN96067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704389.1">
        <property type="nucleotide sequence ID" value="XM_010706087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJA9"/>
    <dbReference type="GeneID" id="22572724"/>
    <dbReference type="KEGG" id="lpan:LPMP_091540"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090020800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_091540"/>
    <dbReference type="eggNOG" id="ENOG502RR9H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10067602at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22985">
        <property type="entry name" value="DD_CrRSP11-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.890.10:FF:000017">
        <property type="entry name" value="Hypothetical_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14952:SF9">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14952">
        <property type="entry name" value="ROPPORIN-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47391">
        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="86"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN96067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="161" mass="17696" checksum="235786515E860266" modified="2014-11-26" version="1">MNAMYSADQINVPPELGTIMKQYTKAVMRDKPTDLYKYSANFFAILSGYATPFDAEGQLTENGVSEVPSCSADPVPVEIQEEESADSQDPVDAILRRYDRTGTGYMDPAELPQLLADLRTSLSLDEKDLDSVEDILAVLPSAHNQIDLLGLRSFLFEGVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJI0</accession>
    <name>A0A088RJI0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNaJ chaperone family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_091440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN96058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704380.1">
        <property type="nucleotide sequence ID" value="XM_010706078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJI0"/>
    <dbReference type="GeneID" id="22572714"/>
    <dbReference type="KEGG" id="lpan:LPMP_091440"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090019900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_091440"/>
    <dbReference type="eggNOG" id="ENOG502S0ZR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050817">
        <property type="entry name" value="DjlA_DnaK_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="42"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="412" mass="46428" checksum="C386BA5BFFF87D8A" modified="2014-11-26" version="1">MQGVARWRVRLFNRARQPLFGASLSSACRHCATVPTEDDVRKAYKILGVHTSATLTDVKKRYGDLAKEHHPDVSNTSADSSTSRMTDINNAYNTVKQFHQAGRQLFEATRASSARGTPNSSSSSYYTTRDTAYQPWYEDMDPLLYEFMWEEMRRQNEEDCFARNMYTERAYRPNGQWQPPHCSPSARPRQSSGNGDGRQSHGGKRCSSSTTWPEEQVKAMVNMYQDGKSFEFIANALGKESAAAVVEEFNRWSSDNQPQRRKGGKPYNAKRHRSHGRQGSFYYTESPDEVPFELYEMMEEELYYDDSAEEAGNPFGYYQGDGEEYDVPYGNATPFYGVHQMNGGPAPYRHFEGGESPIYNSSRKASYRPMRDPRGGVPNKNKRYNAASSSKGSGGGFQSGHGKGHSSSGGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJX1</accession>
    <name>A0A088RJX1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dihydroxyacetone kinase 1-like protein</fullName>
            <ecNumber evidence="7">2.7.1.29</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_100360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.29" evidence="7"/>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696758.1">
        <property type="nucleotide sequence ID" value="XM_010698456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJX1"/>
    <dbReference type="GeneID" id="22572772"/>
    <dbReference type="KEGG" id="lpan:LPMP_100360"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100009000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_100360"/>
    <dbReference type="eggNOG" id="KOG2426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1724672at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10440:FF:000003">
        <property type="entry name" value="Homodimeric dihydroxyacetone kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10440">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.20">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050861">
        <property type="entry name" value="Dihydroxyacetone_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629">
        <property type="entry name" value="TRIOKINASE/FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629:SF4">
        <property type="entry name" value="TRIOKINASE_FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82549">
        <property type="entry name" value="DAK1/DegV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="DhaL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="6">
        <location>
            <begin position="16"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="DhaL" evidence="5">
        <location>
            <begin position="390"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN96105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="594" mass="62154" checksum="94DAD3DBC84BADA5" modified="2014-11-26" version="1">MPGPEMSTVVLKFVDDPHRVVDVAVEGLCEMNNGVKRIEDTNVVVASSIDLTKVLLLSGGGAGHEPAHAGFVAKGWLSAAVCGSVFASPPTSHVSSGIEYLANLQGPNGPGILVIIKNYAGDILNFKYAVRQARAQGIQVETVLAADDAAFGTEDVKKRRGVAGCCLLYKILGAAAARGLSLTQLKALADRVSRNMRSIGASLSSCSLPGNPASSVVPYGTVEVGLGIHGEKGLLQIPFQGAAPLTHFLIGILMGKEEVAVPGKVTAIRAGAKALLLVNNLGGTTDLEMSTLAHHALRELAGEHLTVVGVHSGRHMTSLDMHGFSLTLLIVEDEDDLQYMLNTNALQKPLMNFHAPQWSCATAPGPLTALQLARREVEAARRAAATPTSSPLYVATLRVFEKLFGTEAYFNGLDAEVGDGDLGSGVHRSAVAVLELLPYLPWEADVRRTFTLMSKAVADTFAGTSGPLYGALLLGGGEGAAQALRDGSAVDAVRAGIAQGSHSVQELGGARQGDRTMVDVLEGMRTCPTVATAATMPELLKACYEAARAAADATMMLPAKFGRSRYMEGKEIGKKDPGAELVVAWVEALAFESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RK21</accession>
    <name>A0A088RK21_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nucleobase transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NT4</name>
        <name evidence="9" type="ORF">LPMP_110570</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696906.1">
        <property type="nucleotide sequence ID" value="XM_010698604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RK21"/>
    <dbReference type="GeneID" id="22572922"/>
    <dbReference type="KEGG" id="lpan:LPMP_110570"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_110009700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_110570"/>
    <dbReference type="eggNOG" id="KOG1479">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332:SF10">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01733">
        <property type="entry name" value="Nucleoside_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="398"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="460"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="489"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="525"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="339"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN96253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="553" mass="59904" checksum="5C53B8C2AEF29B3F" modified="2014-11-26" version="1">MEATSKLPQVVMMITSLVVGVTMVIGINAINSAPSFMLEYYKYLAGSSAAEPRSPVFWKNILSFYTMVTIVVQAIHEPTNLTSFMCRFSLLFRLEVSCVIMIIELLVILIMPHTHVSEKNAIAAMMVVAYLGGAARAYFENTGYALFGPCPPTILTGMLIGSAVCGVLVSLLQIILKASMTDSYSAVLWQSLIYFCLAIGIILVAGLLLAALLCNPYARLYVAEFRSSRGPWANIYRRRRSVERVTDGGACGENSATDSKDIAAGCFVADFESEENAEVLRMSNDDVAVSGDRAHHHPNALSDDRAFTTREDFEAGPTRALTPVPQSHDGAAVTATQTEADNCAHPEESPDEVKGEVEAPTKDDLDKSSTDFLAAEDGVLTTAELLQEVRLWPVVKKIYPMMIACFLTFCVTYLVFPGIILAVDSADGWFTTLIIAAHNFADLIGRLLTLWRRLWPPRKAILIGSIARIIFIPLLLLCATHKIPSKAPAYVFTIIMGASNGFLGALSMIYSPATPSLTTDGERAMAGQLTGTCLLIGCAVGSLIQLAEVLPFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKS4</accession>
    <name>A0A088RKS4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="14">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LPMP_070680</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="14"/>
    <dbReference type="EMBL" id="CP009376">
        <property type="protein sequence ID" value="AIN95754.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704076.1">
        <property type="nucleotide sequence ID" value="XM_010705774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKS4"/>
    <dbReference type="GeneID" id="22572403"/>
    <dbReference type="KEGG" id="lpan:LPMP_070680"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_070012000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_070012300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_070680"/>
    <dbReference type="eggNOG" id="KOG0204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000104">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000128">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF486">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 14" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 14" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AIN95754.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1104" mass="121888" checksum="C9D67097504F96CC" modified="2026-01-28" version="2">MALKSPTDVVVITDVPQHHTPVTAALPSPLRPTIPATNPAIGGEIQMQLEDIFARANEAMPLYEKLGRVEGISNTLHTSLTGGVDAATVAARRAFFGRNALPEDPPLTFWAIYKASWEDSMIRLLTVAAIVSLILGLTVPDPGQTEVNYKTGWIEGFAIVCSVVIVTTVSSVNDYRKEQKFHKLTEENSAQPVRVRRGGEETTIDVTEIVVGDVVGLSPGLVVPVDGLYVTGMSVVIDESSVTGENDPKKKSVDAPFILTGTVVNTAESAYMLACAVGERSFGGKLLMESCGAGAPRPTPLQERLNELADLIGRIGLGSAMLLFALLSMMEVLRMLQHEPGTSYLHFLDYFLLCVTIIVVAVPEGLPLAVTIALAYSQSKMHDDNNQVRRLRACETMGNATQICSDKTGTLTQNLMSVVQGYVGMQHFIVKRPGDLLEPVPLSDMRAASLRRLSEGIAVNSSSEKVVSTTDKEGHRVAPYWQWVADRGNKTDNALLDFVDRVAMTEADACDMKSRPHQRTRKACQQRGFTIFPFTSDRKRMSAVVRQEDGTLLHHVKGGSDRILPLCDRYVNETGDEVPMTDEACERIAQQVKKLADMGNRTIGVAYAVLSGTELPEDEPTEALVWLSLLGIQDPLRPEVADAVMKCQAAGVTVRMCTGDNIDTAVAISRQCGIFNRSRGDLAMTGQDFRNLVYDAYGDEERMAKFWPVLDHMTVMARSQPLDKQLLVLMLMTRGEVVAVTGDGTNDAPALRLANVGFVMRSGTDIAVKSADIVLLDDNFRSVQRAVVWGRCVNDNIRKFLQLQLTVNYVSVALTFIGSLMAGGRSSPLTTVQLLWVNLIMDTLAALALATEEPSEECLKRQPIHRKAPLVSHRMHITIALIAVYQLLLTLVLQAFGHRWFGAKRHSREHSTIVFNVFVFGALFHMFNCRKLYDEIDVFEGFGRSRPFLLVVGFCALFQVVAVQTFGDFMDVSRLRFSEWIGTVTLTFATIPLGMTSRLIPAKEARFKREFDAENIDEDAQHFLVRLAKDVERTADERAGRSGEALSKAKRARVLSLWYRAYAKHVGTLRVVNAFHRAHFDRDMTSELSRSVYRQMLKLTSSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKX7</accession>
    <name>A0A088RKX7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_080200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="AIN95829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704151.1">
        <property type="nucleotide sequence ID" value="XM_010705849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKX7"/>
    <dbReference type="GeneID" id="22572482"/>
    <dbReference type="KEGG" id="lpan:LPMP_080200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_080200"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="174" mass="18589" checksum="F164D3326F201EE3" modified="2014-11-26" version="1">MPLSSPPDVKPTPSLPLEGTGRGRLHLYSAASPAHLFVASSTPLPPVGRMAALRLSAPIIPATCTSARCCVETEEGRSRPRRQWCVGLVRFTNKRGDLYTIHRRQRPARAHLPMRRLLCPAHVLRCSCTAAPRAVGSGAGGGVPDAHRGGASLLGKKQRCSGRCRRTTEEAAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKY4</accession>
    <name>A0A088RKY4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Superoxide dismutase</fullName>
            <ecNumber evidence="2 6">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FESODA</name>
        <name evidence="9" type="ORF">LPMP_080300</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="2 6"/>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="AIN95839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704161.1">
        <property type="nucleotide sequence ID" value="XM_010705859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKY4"/>
    <dbReference type="GeneID" id="22572492"/>
    <dbReference type="KEGG" id="lpan:LPMP_080300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_080007800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_080300"/>
    <dbReference type="eggNOG" id="KOG0876">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="239262at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.55.40.20:FF:000004">
        <property type="entry name" value="Superoxide dismutase [Fe]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42769">
        <property type="entry name" value="SUPEROXIDE DISMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42769:SF12">
        <property type="entry name" value="SUPEROXIDE DISMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase N-terminal" evidence="7">
        <location>
            <begin position="34"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="8">
        <location>
            <begin position="125"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN95839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="230" mass="26069" checksum="FA56D46DF06F6F43" modified="2014-11-26" version="1">MLRRVSIKTVMATAAVHASFLSYHSLPELQYPAELPKLEYSYADGIKPVFSARQVELHYTKHHKAYVDKLNTLGTGYEGKPIEEIIKTTNGIAANTVLFNQASQHFNHTFFWKCLVPGGKAMPKPLEAAIAKQFGSVDDFKSSFQQAGMNNFGSGWTWLCVNPKTTELLIDNTSNAGCPVTAGMRPVFTADVWEHAYYKDFENRRADYLKEIWQVVNWEYVAQMYSRAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RL97</accession>
    <name>A0A088RL97_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_140070</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697243.1">
        <property type="nucleotide sequence ID" value="XM_010698941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RL97"/>
    <dbReference type="GeneID" id="22573274"/>
    <dbReference type="KEGG" id="lpan:LPMP_140070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140005500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_140070"/>
    <dbReference type="eggNOG" id="KOG1311">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF478">
        <property type="entry name" value="PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="134"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN96590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="279" mass="31230" checksum="D325FD6AFF08EF39" modified="2014-11-26" version="1">MSDFEVVSSEDEEAGMITVGRSAEMPPYGHLHPFCKGKLLWSPEASHWILVLLTLAGGTLLFALLWGSLRFTDPNLLPNRWMTQLPDIIVVLLAVVCATLLLCTSLTNPGILPKNNLPPLLSSPATKEYCTTLPYCMTCHIHRPSQAGHCRRCNNCIAQFDHHCRLLGCCIGELNKRYLLLFLFSIALYSAFIAVCLAYFLIVVPPKKNFVRCIFSTVGLATTVLLSFISTGYLLHNLRLIRMGLLHREYVSGAPSRNRSRASFATNLMLVFFPRKEWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLE5</accession>
    <name>A0A088RLE5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_151450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697520.1">
        <property type="nucleotide sequence ID" value="XM_010699218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLE5"/>
    <dbReference type="GeneID" id="22573565"/>
    <dbReference type="KEGG" id="lpan:LPMP_151450"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150020400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_151450"/>
    <dbReference type="eggNOG" id="ENOG502RZ4P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="242733at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="633" mass="70737" checksum="D2F719DFE095D65E" modified="2014-11-26" version="1">MMRHFRVSAATQPQCTARTKMTGFNLFTQSMQKEKKVLKAKSLKGGYGNMRIMATLWGKLPAFRREMYNSQALQRAALMTGDPEKKHNKFNLLMRLFGSNKVLLKAGDESFTALMAKSTMQAMSNKDTRQLQEKLKVKKFSTSAERAHVNVASTFKRFVSPSMLLFNSFTEMQRSVTPTRKSAFTAVAQLRSFSNITISGEKLVMHRYSSLPPELRNLFAPISDIEAPFFELFCASRCAGFNRKRFEIIRLFASFRGIKVDLGSNAVQDQLFRSLVNTDRSRDGIYFRVHRSLERLEMLRSSDCGFFIAKRLLQSIKINRAAYSLDSSLDDVSVATLLAETRSGQSVYDDVLTRAAILRTSEKNKQLSVYNVAQMMQTETLCNKQTRVERVKKVKVTPELSPSKLMLKLKAARAPLKKKLASKTKPQLAQTMPIVTKEVATKAKPEASKRNAAPPMKRQLVTKRTASVSRAKTKRVPATRRVHVKVGAARKAVAAASKKALKKVATTPQATAATDEDDDLFAEDVMTENEGSDVDPDFVDKFADATVAPVTQPTAPAKQRHKETKRRAVRSHLLAPESMLPAAARSQKVITAHTSTCKKAPRPVSTSHSLPFTPTRRKISFADNIRAQLASFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLU2</accession>
    <name>A0A088RLU2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_150630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697438.1">
        <property type="nucleotide sequence ID" value="XM_010699136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLU2"/>
    <dbReference type="GeneID" id="22573483"/>
    <dbReference type="KEGG" id="lpan:LPMP_150630"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000042400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_150630"/>
    <dbReference type="eggNOG" id="ENOG502SKTJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267813at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="136"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="261"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="313"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="388"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="680"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="804"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="652"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="330"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="345"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="357"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="388"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="415"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="453"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="811"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="847"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="880"/>
            <end position="891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="928" mass="97016" checksum="D3FA538FFD10F80B" modified="2014-11-26" version="1">MEPGVHPQPHPNASFYSPYSQSTSSSQQYPQIRTDTTMVSSINSSCAADLGSKSASAAVAPSRSGSLYGGLRIATPHSPVTGTVHQPTPTQAQQSHTPHQRTSPKGMPSQHRFAMWNTSMTCSSSEDAGNLGLHRSFSTPNEAHGSQHQNFHGQHPQQHRQTKALPPSFERPSSELMDTVSRSLNTHNDPELEGLPPMRPDDEDEDEMEGHPGGVVKAAGHATTLYSKGFLIATTSSIKDSPVSCGDGGDNTCILRHLHDGEEQQPPRDDGEASVSQTSQSRGPTASSSTGISHRLLTVEEINERRRASWVASHSVSQVQSAVACPAPGDDARSEKRPGDPLKSAHSTNNLSTESGISKDSRPAHRQLTKEEADQLFAQCQQQRAAAAAKNITAPQQQQHGLSSSLANAANNSNQSGVIHSSASDSTKPWLLSGDDSRAHCFHPTPTFRPPVTSANTVGSGGNTATKPMTFEWLRGTSGGVGASGTGFFAESTVHPWPGVNAWRDSNVAGSSSTVNVSAAMASCFGTTGVPAGDVGSSGDFKVSMGTLAGASQAPGGPSTSGFAWLPNTLSWTPQNQQQAQHQRAVFSFVPSAPPQVGPVSGATNAVTWGYSPIAVGLSGSGLPSSSHAYLPSLPAAAGLQGLSQERIEECIHHCDMQLGQLRQEREQLLQELQRRLHAAADGEQQQRLQQQQHQHTHSASWPGALGPNAATISNSIVDIATARPAIPPRGAVTAGARAIGGGGSTFGQGPLWNCFGDLVVDGNVMTNAFPRGPDDTREPPGLCVDPIMEVDSEECLGRTPTAAADHRQLSSSGSATTGGPAHQAAAGSRFTGERPGGLCRRRAEAGSQRNSSGGNSKNGVSSLAGLEATKSSAGGGGHSTNRCSHDNTPQEQKYLQTDPFSMYMHNKKLATTGGMAAPISSKASAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLW6</accession>
    <name>A0A088RLW6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like modifier-activating enzyme 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">UBA5</name>
        <name evidence="9" type="ORF">LPMP_150980</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697473.1">
        <property type="nucleotide sequence ID" value="XM_010699171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLW6"/>
    <dbReference type="GeneID" id="22573518"/>
    <dbReference type="KEGG" id="lpan:LPMP_150980"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150015000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_150980"/>
    <dbReference type="eggNOG" id="KOG2336">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="206053at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071566">
        <property type="term" value="F:UFM1 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071569">
        <property type="term" value="P:protein ufmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00757">
        <property type="entry name" value="ThiF_MoeB_HesA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000531">
        <property type="entry name" value="NAD/FAD dependent dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF9">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="8">
        <location>
            <begin position="22"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN96820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="411" mass="44123" checksum="D8FAC7317C7D1A7F" modified="2014-11-26" version="1">MSSSSSPAPRKFSAEVRDDNPYSRLMALQRMGVVDDYESIRDKAVAIIGAGGVGSVVAEMLTRCGIGKLLLFDYDTVEMANMNRLFYRPEQQGLKKVEAAKETLKDINPDTVVEPHAYNITSTEQWQRFSDALTKGGVSPNSPIDLLLCCVDNFQARLTVNLACLTYKLPWMESGVAENAVSGHIQLLLPGVTPCYECCPPLVVATGLSEAKREGVCAASLPTTMGIVAGFLAQNTLKYLLHFGEVSEYIGYDAMRDHFPRVELKANPECRNALCGERQAAYAAKVRAMGEAAHPLYAARKARADRAEKEQQAARARAKACAAEWGITVEAEGKDSLVVHGKMVGSSSAAGEASSTTTSALPGREGEGVSGLEYAYAGTAGDSANVADEDKYVKTTGASIEELMARMKAIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLX9</accession>
    <name>A0A088RLX9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_101050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696827.1">
        <property type="nucleotide sequence ID" value="XM_010698525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLX9"/>
    <dbReference type="GeneID" id="22572842"/>
    <dbReference type="KEGG" id="lpan:LPMP_101050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100017600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_101050"/>
    <dbReference type="eggNOG" id="KOG4265">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000696">
        <property type="entry name" value="RING zinc finger protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045194">
        <property type="entry name" value="MGRN1/RNF157-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22996">
        <property type="entry name" value="MAHOGUNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22996:SF0">
        <property type="entry name" value="RE60872P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="307"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN96174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="355" mass="39050" checksum="1B5D27006C8294EF" modified="2014-11-26" version="1">MGNQTSHQQPAETVVTDLELRLAPQNFYLVFGKPSIHFTRERVRGPLIYDVEVEYDDDENLVEHAATLDLTCAVPRRQKIELISVPPPSPGVVGASKGLALTFQIAATQPPQRVCVYTGVSVEYRVRDGVRLKTSGGVAEGSVCIFDTTETDGLTTVVTNPLVLLQLLQPVKYEEIADTPAVSTVQRVAYAPLVIEVVIGETEEHSKKSQRFAPADKTAHEATQSKPRKKCIVQYTFLEAPEEGAKLAGSSRGCGEAQPAHRFACKVAKQLLQVGNEVYDLEDVFDDGRRDDVRDAAGDEEDMEGLCVICLTNQKDTTILPCRHMCLCNTCAAHLRLNNNRCPLCRANIDRVMTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMF7</accession>
    <name>A0A088RMF7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_180210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697855.1">
        <property type="nucleotide sequence ID" value="XM_010699553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMF7"/>
    <dbReference type="GeneID" id="22573911"/>
    <dbReference type="KEGG" id="lpan:LPMP_180210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180007100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_180210"/>
    <dbReference type="eggNOG" id="ENOG502RZJW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000851">
        <property type="entry name" value="RNA-binding protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343:SF22">
        <property type="entry name" value="LD29830P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343">
        <property type="entry name" value="SERINE/ARGININE-RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="10"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="365"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN97202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="405" mass="43630" checksum="9EC572EF48E5E380" modified="2014-11-26" version="1">MSSTPMQTRFGCYIGNIDRSVTIDMLRQVFCQCGTIIDCSLNGREGDPYRFGFIDFATEDDRARAMKYNGFTLVGRKLKVGVSKGNVNKPEGFATGNGVGGGHLRMGGNHRHYNNDGSMMMSVNGLSPQQQMEARLLLQFLQEGKMDPRQLSPAQQQLLITYLGHGNSNNVTNGSSTNSGSSTPALAQQSQMGVIGSSAMQSPLPPPTMHNSNNMMSDAAAFMPSSSVGNSGAGTGMPMMGGGAPQGIHISVGPSMMDPMSGGYGMMPPPQQQQQWVDMPMNGPGIFPPKMCGPPLSQQQQMPMQSSLQQPYNLGGGAALISGSGATEHNRSAFVNPPPAVEILKLRERQREQFFEVVRKDAEKYERKLQEKKAHSAAGGDAERSIDSSASDDDEDKRPTKRSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMN5</accession>
    <name>A0A088RMN5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_130650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697147.1">
        <property type="nucleotide sequence ID" value="XM_010698845.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22573175"/>
    <dbReference type="KEGG" id="lpan:LPMP_130650"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130010700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_130650"/>
    <dbReference type="eggNOG" id="KOG1031">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="419768at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010828">
        <property type="term" value="P:positive regulation of D-glucose transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090314">
        <property type="term" value="P:positive regulation of protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031340">
        <property type="term" value="P:positive regulation of vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038983">
        <property type="entry name" value="C2CD5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057815">
        <property type="entry name" value="C2CD5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056431">
        <property type="entry name" value="C2CD5_YbjQ-rel_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37412">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37412:SF2">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23025">
        <property type="entry name" value="YbjQ_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23128">
        <property type="entry name" value="YbjQ_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="643"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="750"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1105"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1191"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1292"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1614"/>
            <end position="1653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1825"/>
            <end position="1844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2014"/>
            <end position="2048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1108"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1159"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1191"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1203"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1226"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1245"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1265"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1615"/>
            <end position="1631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2048" mass="218054" checksum="52373D301B3F2800" modified="2014-11-26" version="1">MATLKVTVHEARDLPIMDRATGLADPYVVVKFDDMEHTTDIAHLTRNPVWEHDVRFDTADLLVLQEDPLEIRVYDHDIISRDDIVGMVLLDCNSIIYRANPVMSGWFPLLDSGAGLHGDIRLTIRIKFHAAENPLAPALPERYVRRLDPRVAERSPSLAATAQGGNGSHAQHASSNPRTNETSVSFTMATSASCLNAATTAQSSAEQNPTASFNDPCKAFANSVNVNNNNESVGLSTSSAGHHHHQHRSSLRMSTRARNSSKAQLHVSSHCGSAPDTVADLPSLTGASLNLANNNISATTMNSSAKPVIGPSANLSRYDLSALLVRPSGAITTQMAAVVESPATAAMPLPLPSPALLPFLVEQDLDPLRAARVDHPTLAAEEEGIFVFSVWRLDPAVFRVESTHSMMEELIVKADPEHVRFTNLRSSRSINDARVIQLFKLSGKVRRQLARKVVELQCNAVLGYVEEFDMEPNGIIVRAYGTPCVVSHVKYVDQREMEAFLRGKTRYIQSNIMAAYQAEFPNASITTAPPQSQSPILPPYGVSPIPSNGGGGGNAGGASTPVTPSGTTHSANSVALGNKMPPLLPLPPTTTPSSVLTTAHDHVLPPPISACASQFGTTSQKLQSDQLVVAVSGTSTPLSSIEAAASTTVQSPGAAQETYESATETGDSVGDSAVPPLSLENGCGVAEPSAATPVSTLVGAQSANSTTHHYSPTASTLANSPLCFSLPYSRSFLAHSMDAATLMSAEALVPPPSQQQQQSSSHANLMMRSGPTDTTATTAAASLVPAPALTAPPTAKAVVTAGNTAAGGGSPTRVTISILTVKDLPAGSIHHIGGYICARSVKIVSRVKSRQIISQERDAWWMELREELRANARAFHCNTVLGYEEETQYHEDVVLLSLYGTAVMLDMSAASLRAGPEHLFCWQKQRVASKRNCTLLHLYEGSRRKGGLGFLAGEVSDLLMHHVCTICHNKPVPDVLLAACTLPVELNCEAPPRLVQVAVSKPKPNVKGVELAMAVSQALPFIEFALHKQLLFNLRLQQLNACFSLRVSIVVGHDAIVGMLTGSGCRLAGLPVPRLPRMTVVDPQIAHKESVVRLRDVIALRRRRRNNARISSSSRSTSSTSSSSSSSNRSSRSAAAVQSSAMPGVNGNGPSPAVSATRRRGDGSRDDARDVDSAGTKAPNAALTACFFTTSSSSRTGSSSSAFKRRKRHRRRRRRHRSHGNRGSSPTSHGFSKSSSVTDALLSPASGNESLRSGQSSNTAVAPAQKRRRHRRTRQASTRAAAVAVAAAAAATGARGVMGATSGSQSRGPTSSKSHSPSPSAVMLSSRSYSSSRSSSSSRFSTSSSNTSLHSWVLTESSETDEDVYAPADEWRTTSGGVRTKARDYVVKIDDVEEADMMLGMVDATNFEDGVLLTLPYVPDSANAFDLQERIVLYRRYSRASTFPFAVGGGAGAAVLTGSGNRAVSPGSRATTGESSVLGANVMGGRSAYQSYSGPVPRTAGGGDGMNAGGGTAAAGRMALTTRLLNEYCADAKRAFVHRACRMAMRSGQPLWLRVVNLRVEMMFVPNSAELQLRLEGCLMVVSSAGARHQLLELEDRAFRVCMHYAMESLSGLRQYQQQQQQQHPSQASQSNHGGGSAAGQRATSGNPSPYLRWTPHTPLLSPLVTDVASNNLVTTSSGGHAAAAAARQTPSAQNPSMPQPLAAYATACAAHNHKAHAASLMSDMLAMSSVLATVGSGPAYLDARRLFIASNAPFSMPYVQDITLSPPRVWSGVATAVSEDTAAPVRHISTYAEYRDSRGSRANSLSRRWNTFVRAARQSIKSLVGRATASGTGDRRKRQQKRQWLTSPFVLNPSARAAEENGRSLMLMGGTAGDSSSMAGAARDANYGNPAARLPKDVSQLQILIPVVHFTPLDYIAGRSIVRYLGRLSQHFIREDYETDTGDGLNMFFQRAETEIVCTVQALVRLMGGNALLKHRIVYHEICDSDGSGRAFLFATVTGDVVQVSDTAYWGRHAQQKGGSSRKNGKDITTVDFSDDGDSGGAGSRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RN36</accession>
    <name>A0A088RN36_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cation transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_191260</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698120.1">
        <property type="nucleotide sequence ID" value="XM_010699818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RN36"/>
    <dbReference type="GeneID" id="22574180"/>
    <dbReference type="KEGG" id="lpan:LPMP_191260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190019700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_191260"/>
    <dbReference type="eggNOG" id="KOG1485">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="435980at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF15">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="8">
        <location>
            <begin position="58"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="8">
        <location>
            <begin position="228"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="182"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="478"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="479"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN97467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="615" mass="65594" checksum="52E11E401509F4F9" modified="2014-11-26" version="1">MRRFFVMKSPAVAKTTAGAASTQLNTHSHSHSHSHGSIEKNISGKLLRQCQIATLAGGATNVFFCVTKLWIGSAGGSVALLADGFHSLTDILADIISYAAISLSRKKLPRCRFPLGIGRLETSGAVIVAAILFFGGVALLIQSLEQCFSELATLLVTAAPTRGIAAVFGISSHRAMPEASGKSTLASATAGHDHAHGSHMYSHAQSNGGGDHQGHSHFQVMQYDEGIGEQVILWTMVGIAAGSVVCKELLFRWTRRVGLRAGSRVVLANAYHHRADAWSGGVALIGVAGQVMGLPGVDGFAGLAVSLSICKMGYGIFKDAVLEFFDYQNAKEVCVIREQLQKFNLHIVRGVDVVPNYNSQDAVKAATSEAEASSANYTPTALSSDEDDTVHRKKIHFINVFLVRHGHQYAVHVTLLVHESVSAQKIQEATDLITALARRSLSVQDTFTTLLLCSNYTESRDVSLCGCNNDAKGTDEEAAAATSSGASAGDHHHHHSHAGPSDSYSHTRGGDDNATSALPIAATGAIINPSLERCITSLQEFHTFTAPIRYSWEERTITAPSSESCECERDISSVAEMFKCRLVGGGLISSRKAAEDLAERSCHSHFHGAHPGHSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNB7</accession>
    <name>A0A088RNB7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pyrroline-5-carboxylate reductase catalytic N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_141260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697357.1">
        <property type="nucleotide sequence ID" value="XM_010699055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNB7"/>
    <dbReference type="GeneID" id="22573393"/>
    <dbReference type="KEGG" id="lpan:LPMP_141260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140018200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_141260"/>
    <dbReference type="eggNOG" id="ENOG502SC9D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="248224at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF58">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="3">
        <location>
            <begin position="114"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN96704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="573" mass="60448" checksum="408E0068510B021E" modified="2014-11-26" version="1">MNADYALLLNTVLSESGCADASLQHTAETVPLVYRTLAEHNYYLLYVVSVVKALLHEDDAAFAHLARAQAQRQQAGAETMSTPAQPQLSPDVTIRSSSTLPPLVPSDRLDMQLTIIGGGTHCELMLRLICGCGGGTGIFSSPATRDPLVHPSHITVITRQPERLAPYAELGVHCLARHHGRHAVAQSDVVVLACPPAQLQEVVRDLFASAATETTTSAGLTKNRAVVTASLPSLPNTAAAIHLLRPNTVLLSCMSGVPARRVTQAFQHSHVDLTFIPSLHTFGAHAPSTAPLCDSDNEPSTTASSSACSLPKGPPLPIDAAATPEKCNEGLNARSLEEAGRCFTVAMAAYRSARIVEMRSSSSFLRPAVLQQAATSAAAEAATLWREPQLPGGRLNLPGAAPPRLTDFTAGRHPSTWPTLVEYVDLWRVLKAYVQATFAEEAMKLACGRGGGGGCPRRRSNTGIGGSYGGLVSVVLPHAASKHHRMSEPGEVEGELLPALVLLPAAQTRVLWDAWWGNSGHSALTAGGDAALSLPPSVTDVTGAWLSRVYTSAAALKASLDDQFGHVLGSHTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNR4</accession>
    <name>A0A088RNR4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_160190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN96894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697547.1">
        <property type="nucleotide sequence ID" value="XM_010699245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNR4"/>
    <dbReference type="GeneID" id="22573596"/>
    <dbReference type="KEGG" id="lpan:LPMP_160190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160006800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_160190"/>
    <dbReference type="eggNOG" id="ENOG502SEZF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="263775at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="184" mass="19740" checksum="0E3A0DF165902FB1" modified="2014-11-26" version="1">MHNEPDGRALQHIGGDVRRHSNATGSNHMLASLMEDAPRTKLSSYVTPHDAVQAQPAQHGATVVRSGSSATEGGSILFFSSVQKKGGAFTASERETYAQLHRSRVIPNVNRGRNAGNVMGSGVSAKSVTRQYAELKKDREALEIAQAKATVSGSKRSRFALDDSPSEEDEYAEEDDIGAEISTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNS6</accession>
    <name>A0A088RNS6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Kinesin, putative</fullName>
            <ecNumber evidence="1">5.6.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_201100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.6.1.3" evidence="1"/>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97603.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698310.1">
        <property type="nucleotide sequence ID" value="XM_010700008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNS6"/>
    <dbReference type="GeneID" id="22574318"/>
    <dbReference type="KEGG" id="lpan:LPMP_201100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200021200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201100"/>
    <dbReference type="eggNOG" id="KOG0243">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97603.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1078" mass="117242" checksum="56F2E3792FAB2F69" modified="2026-01-28" version="2">MRNADSREDTPSPPRRTRQVVWNHRNVDAIPSDLTRTSAHVDPISSSGAVNATRTLRESKRYFGCIRVVVRCRPLQPDTEADHSAERVHINGDEVIVRDRMAPNEGRSYRFDRVLPAEADQVATFAEIAPLVEHVLDGLHATVLAYGQTGSGKTYTMDGLRSSRLNLQQRQTMVPHVDGTAVQQHGIMLRIIQLLFDRARERQRAVGVEDAESPDNAGTTDDGVVYTFRCSFYQIYNEKISDLLRGIGVSANANEAAAPLPFSSSTLAKLQMDARGKRGVDQGDLRVRWHKGDVFKVENLFICTCNSPDEMRGMLFSGIQQKIVSGHLINRQSSRSHCVFTIYVESRARQNGELLSQSELSLVDLAGSEKIGLLSHRPGAKLIKESIDINTSLLALGKVITALSGGAAEATSTLKRKNAGVVSHARGGAEQHTGGRHIPYRDSKLTMLLKHALGGNSLTTMIACISPSDRYVEETISTLMYASRAKSIRNAPHVNEDATTLLMRKLRGEIAQLKTEVGCYREMAMKSLVEREGRANVCERCSGVVYTNSLRPADPSSSIGRSTAADVTTGQEVDELADSLVVACGMLAKLMQANAELREFYDTARGVQDAVERREAELNAENLSLRERLAMLEDIVLQEDLEEVKEDSLLGDADAKGMLNSSKPPKQARPSRERPELSCAVGGPLSAVTQTTALPALEQCTGDRASSAGAVNDSATGGSSSQRSTVSSTDVGRPAAVGNARCEPSKRASTSPSTRSAARVSAPHSGAVASPVRTRALGPSPTVEQLSSVLHGLPSGIPALGDASEALLMRRADRASLRKRATEDKDGRQEHGRKKTRKKRSGGLARRLTEYEARYRMPHTTETYADYYQQPVRSKSVAVVVPGVPAIRASETASMQVTAALQDMRITVSKLPKAVVREYVPASLLRPGMFGSLAFGGEDAAKMRFEQNRCAREARLRESKQRQQELYRKVHLAVHGLRSEDQASVGVAHSSSSASSLETETPQQANRTSDYTSNPGERETESCRSGLVYPICAPTSSCAPLAVKRAGTAPYCEPSVRQSPSASFASMTRLMEYVKHNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNU2</accession>
    <name>A0A088RNU2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_160450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN96919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697572.1">
        <property type="nucleotide sequence ID" value="XM_010699270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNU2"/>
    <dbReference type="GeneID" id="22573622"/>
    <dbReference type="KEGG" id="lpan:LPMP_160450"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000051000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_160450"/>
    <dbReference type="eggNOG" id="ENOG502S2XA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271832at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="260" mass="28566" checksum="3ECE815FF5661027" modified="2014-11-26" version="1">MWQRSAPQLTLALRCTRVALAPRQPSSSATGRGNSSSSGFGSGWALPKQIASWYPRKVGEFLANTIAGHNTFIQDIPTRFDEVHARHFSLVEGLTITPLYTLAIVHYFSIFCQYPTRVELLKPMLDELGRKSTLQCHWLLLMQTKRTPAEIIAWRCGLLTLQFVLFPIWLFLSSTAPQLVHATIAFSSHILHTKYGCLSSSGSSSAGGRAAAAAVVPEFVLKGADMYAAMQTFHETQSVTVPTDFGVAVVMLLLILVLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RP51</accession>
    <name>A0A088RP51_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aminotransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_202090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698410.1">
        <property type="nucleotide sequence ID" value="XM_010700108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RP51"/>
    <dbReference type="GeneID" id="22574418"/>
    <dbReference type="KEGG" id="lpan:LPMP_202090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200026400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_202090"/>
    <dbReference type="eggNOG" id="ENOG502S2D2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277045at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000019">
        <property type="entry name" value="Aminotransferase class IV, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="354" mass="38810" checksum="135BF2C236C0D106" modified="2014-11-26" version="1">MEHIPLVVRRMVAVEQSCGFVHFFPSFCDVSAAPLVIKTEAFSSTVASDAADDAAPAYQFVYDVMRSRNGHILFKQSYAERFMHSLTLAVPTHAFSAELQSLIQSRLQAYIEAPGVYLDGATEKNVKLLSWVPTAAASTNQAETLPIPVIVMLAKSSYPAESLYHEGAKLGLLFNAHRINPNAKVAQMGLRDRANAYLAENHVYEVLLVHDAADAYLVPEGSRSNYLLQKSNGTWWCSAEEDILVGITLKTAYRVLQACGLGSVQHAKLTLKDILESKSLYILGTSPTIMPVQSVLLYKDAETRGYYEEAVRALGATAGRVKQVSDDKAEILIPMNEELATTLRAQYFAEAASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RP66</accession>
    <name>A0A088RP66_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="5">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RH</name>
        <name evidence="6" type="ORF">LPMP_201110</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="5">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="5"/>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97605.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698312.1">
        <property type="nucleotide sequence ID" value="XM_010700010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RP66"/>
    <dbReference type="GeneID" id="22574320"/>
    <dbReference type="KEGG" id="lpan:LPMP_201110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200021300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201110"/>
    <dbReference type="eggNOG" id="ENOG502QSVA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10256233at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN97605.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="775" mass="86952" checksum="3C7103CC2BB454AB" modified="2026-01-28" version="2">MPRLAATRNWLLRRYTASCTHRLSAFSYLVITTRSVVQSNMTGGPRSLLDQFETRELVTRLRRNRNGNYYRFRQKLWPSQEALEKAVTTMTYSPVERQPLALLPQREAPRQVFACEGRGGSMLLEAVETEERGASALQSSPASAAVPLLRSQSESGVDSDSLDFMEEVLRADQSVSSKIMTEADVRGTVLGSASTRARQILAGDLTCNPVTASHSTSIFLRRPAESTDAAGISWSGLGLDAPISSAAEQLYGPVPTRLQTRLLSALLHEDHNDVLFNGVTGSGKTSALVLALLQGIRSEAAGMNVLVATNTMNAMRLHDTVKALCRRAGGGVVVDRPADDYSWLFLGTYREDHESYYRQLRRGLRRSTGPARLFITTADVMCQLLFEKKMEFEDFGYLRRVYVDDVGAQVPMLPESVPVEVVRERLRNPLAAELLLGTLHQLPGPHIRSVLQLALVSADVDGKLKDHLQGLCMKPVAQTTVLSAVRVPSAVHCLFSFFLGHKEDRFTYLVRVLWNARETIPGRAVLFVPDAEDVLSARRRLRGLGVDARLFSEVYGGNEFKADWKFLLLRESEAFGVDLPLVSHVFINFAPTSWQSLLHMCGRTGRMGNVGWVYVVSDKQEAKRVRQVAEALSVDFCNHVIDEDLQQVLPAHVERFTKQPELYGLDPQFAVRQHYTMQAESPDMAYRKREFFSKPAIKQFQMEDHTSIPLKQRRFDHARQLSQDVARNPSLVLDMQKQGLLDAQLKPTKKLKRCMDVTTNRHAPDPFQKGQRRCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPL9</accession>
    <name>A0A088RPL9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">1,2-Dihydroxy-3-keto-5-methylthiopentene dioxygenase, putative</fullName>
            <ecNumber evidence="11">1.13.11.54</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_204190</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.13.11.54" evidence="11"/>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698620.1">
        <property type="nucleotide sequence ID" value="XM_010700318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPL9"/>
    <dbReference type="GeneID" id="22574630"/>
    <dbReference type="KEGG" id="lpan:LPMP_204190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200048000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_204190"/>
    <dbReference type="eggNOG" id="KOG2107">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1867259at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010309">
        <property type="term" value="F:acireductone dioxygenase [iron(II)-requiring] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02232">
        <property type="entry name" value="cupin_ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000099">
        <property type="entry name" value="1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004313">
        <property type="entry name" value="ARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418:SF5">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE (FE(2+)-REQUIRING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03079">
        <property type="entry name" value="ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0533">Nickel</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN97913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="280" mass="33024" checksum="8DE700C4A445A055" modified="2014-11-26" version="1">MEGISEEQRLREEAEIRERDRKRQQEKEEYERRLTEERAEEDRKRREAQQLRLEEEKRKKRQEEEWKRLGPDVIQDLPPVPPPVSEEGALEMWYLDDETSQPPLSTASLKPGRKVSAPAVTMKALRELGVVLFRISMSDFSVVKQIIKEREYKHTDEVKISQTAKDDSFLERWYQEHYTEDEQFRVVMDGSFYLDIRSKQDEWIRVHLKAGDLVVLPAGMYHRATLDEDDYVALYRGFQDAPCFVPVKRSDSRADSNRVRLAYLMSLKKGDVATQNGFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQ43</accession>
    <name>A0A088RQ43_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_190270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698022.1">
        <property type="nucleotide sequence ID" value="XM_010699720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQ43"/>
    <dbReference type="GeneID" id="22574081"/>
    <dbReference type="KEGG" id="lpan:LPMP_190270"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190011000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_190270"/>
    <dbReference type="eggNOG" id="ENOG502S0B6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10064100at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000791">
        <property type="entry name" value="Putative RNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19851:SF7">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19851">
        <property type="entry name" value="OS02G0203500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="313" mass="35518" checksum="43A0ADBBDFC54364" modified="2014-11-26" version="1">MKSNIDVDVAPMGAYHGDGMREPGMSTSEPMQVVYNRIQKRMPMFRNSLVIQEQQMMHMTEELRTLVMDANALRVHYEEALQEKLYIENLAAQAEKRVQNVKEIVDRYVGVKDAVVASDGFTYERETISSYIEGCKEAGGTPTSYQTEKPLTSLLIPNRSLKTLVDRLVTVQKTEPKMPAPVDRNPVQHYSKPMATGRVGNMSGSQNDAQRRSIQGGGKDNLSPVELNAKGERVHPCIRVYGYCNYNENCAYAKYPYDACLSNLKNKCRFKNQCHERHVEFRGPLDDYGNSISENHGPHQEKVASDSMEEMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQA3</accession>
    <name>A0A088RQA3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Exosome associated protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_205540</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN98045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698752.1">
        <property type="nucleotide sequence ID" value="XM_010700450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQA3"/>
    <dbReference type="GeneID" id="22574766"/>
    <dbReference type="KEGG" id="lpan:LPMP_205540"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200062400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_205540"/>
    <dbReference type="eggNOG" id="ENOG502RNG9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272245at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF33">
        <property type="entry name" value="RNASEPH-LIKE PROTEIN EXOSOME-ASSOCIATED PROTEIN 1 RRP42 HOMOLOGUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN98045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="403" mass="41958" checksum="F0303A3DB22C79B7" modified="2014-11-26" version="1">MPLGTASISLAEVRAVQGGVANDVREDGRTLLQRRPIHITARTSPSSLVGAASGDVQGSYNGSYVEVNASGTVVLAAATPSVVDGCATADSNSSAGAEQECAPDTGKGQLYITIDAVPHVLDTYASAVGGRNVVRYRRDYLAFLASTVRQVFGAAQVEVQEQQGMAEAEVVPEDAGEVSDTAVTVSSASSSAGKSGAAAGSRGDHLLSGFPAADLYVGEGFGFRIHVDVHVLQCSGGNLFTAIAYAVHTALRSLRLPAVTLHKAPGDGAGVSVEVDRSQPYRKAISWAQIPLLCVLLVSPTGHCVVDPTLREEWAMPQQVHVAAGASGQVVYFRYQQLPSRRGNTYQLRSAEPSSARDECAGYVAPPPALSVNDCWSILSDGVHICQAMLHDCEDALTHGGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQE7</accession>
    <name>A0A088RQE7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">N-acetyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_220430</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. MAK3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699044.1">
        <property type="nucleotide sequence ID" value="XM_010700742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQE7"/>
    <dbReference type="GeneID" id="22575089"/>
    <dbReference type="KEGG" id="lpan:LPMP_220430"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220009300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_220430"/>
    <dbReference type="eggNOG" id="KOG3139">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="249099at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000255">
        <property type="entry name" value="N-acetyltransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044542">
        <property type="entry name" value="NAA30-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="107"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN98337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="288" mass="32523" checksum="9559FAA75F216A81" modified="2014-11-26" version="1">MPPKNVKRNQRSSKQRDNFDEATIDALVKAIEGKTKKGTTKSQLKQKEDKSLKCVNGENYVLSEQMRDALLAQMHQSAAQEDQYVNVPVPLTEEEKEWQEVAPNKYIRYEQFGGSDEEMSFIVNLFTAELTEPYSSFTYQYFVFGWPDLCITAFGVESETKPDKTVVGDKVGAIVSRVTRKGPGMPLRGYVAMFAVVPSFRGYRLGSRLVSRTVELMRAKDCDEVYLETPTSNARALSLYLNLGFAKTKFLPRYYLDHSDAVRLKLWLKDAVPKPSPETAAVEGKADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQG7</accession>
    <name>A0A088RQG7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cytochrome-b5 reductase</fullName>
            <ecNumber evidence="4">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_220680</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="4"/>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699069.1">
        <property type="nucleotide sequence ID" value="XM_010700767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQG7"/>
    <dbReference type="GeneID" id="22575114"/>
    <dbReference type="KEGG" id="lpan:LPMP_220680"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000049400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_220680"/>
    <dbReference type="eggNOG" id="KOG0534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000032">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000009">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF131">
        <property type="entry name" value="B5 REDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0274">FAD</keyword>
    <keyword evidence="5 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="11">
        <location>
            <begin position="35"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN98362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="289" mass="31980" checksum="5B09A34B7296A951" modified="2014-11-26" version="1">MKAFIASVVGFAGASMYQSGSEVQAWGSKPAFSQDKFQSYKLIHVEDESHNTKRFRFALASSKTRLKIPVASCITLRYTDAQGREVMRPYTPINLVEDEGHFDLVVKCYPNSKMGSHLFSLKVGDSIDVKGPWHTFDMKPGQYSKIGMIAGGTGLTPMFQIVNNTLYAPNNKTKISLLYSNRTEGDILLGKELGALAKEYPGKFVTYHCLTTPPRRWTGYSGHISKAMIQETMPGPDHRGDSCVLVCGPPPFMKSICGEKDYSCSPPKQGPLEGYLKELGYSESGVFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQR1</accession>
    <name>A0A088RQR1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RecQ-mediated genome instability protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_230100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699169.1">
        <property type="nucleotide sequence ID" value="XM_010700867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQR1"/>
    <dbReference type="GeneID" id="22575214"/>
    <dbReference type="KEGG" id="lpan:LPMP_230100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230005800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_230100"/>
    <dbReference type="eggNOG" id="KOG3683">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="341511at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.770">
        <property type="entry name" value="RecQ-mediated genome instability protein Rmi1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042470">
        <property type="entry name" value="RMI1_N_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013894">
        <property type="entry name" value="RMI1_OB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790:SF15">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1 RMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08585">
        <property type="entry name" value="RMI1_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01161">
        <property type="entry name" value="DUF1767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecQ mediated genome instability protein 1 OB-fold" evidence="4">
        <location>
            <begin position="54"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="240"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="288"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN98462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="343" mass="36582" checksum="148B24BEA50B2786" modified="2014-11-26" version="1">MTALVEEIREKYSLSLSADYVERCLQSKASLTSLELYQKSLSENLRDICGSSLLPYGIATQVSATLPNAVVMQINASRDATQPLRPCADTSEEEAILNAAVQRHSSKRLLRLQLTDGNVELPALELSTLRVFKGIPTPGEKVLIHKDAEVHNGCIIFSESNVSLLGGEVHQLKQDFLAHRRRLEAGYQTSNGLDGAPRFAPLMVGQQYHRNVTHIGSSADMGQHGGTTLCNANGRGRGRGSYAHSGGGAGYAQQANDSYGRRGRGGGHSRGGRGGRGGDNAYGNDGWRSGGRSGGGHGGRGVGGGVNYCGRVGDVSHHVDTANFQPCTEKFPEINEANFPRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRC6</accession>
    <name>A0A088RRC6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_231840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699339.1">
        <property type="nucleotide sequence ID" value="XM_010701037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRC6"/>
    <dbReference type="GeneID" id="22575389"/>
    <dbReference type="KEGG" id="lpan:LPMP_231840"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230026600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_231840"/>
    <dbReference type="eggNOG" id="ENOG502S6MU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271049at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="339" mass="38217" checksum="3B18D47F35B55053" modified="2014-11-26" version="1">MWALTSRPIYSTEALQLMERYKVHNALQSNRWLLPRHLPLFAVRPLYPAQLVLPTSSVIQLPLCAVPFCSLPTWRKREILSLYPPPSTPPGSCLFLDSSGSDTRWRPASMSECFDAAFVRSDSPASHQHLLCAADCAAGGTFAEEVTVLNAQETNNPFLVDADLTHRNLLDKVAFQHSIGSSLTTIASQFRYTSFDWVEVTAVAAAGLRVCANAEPHLVSCADELRVVHISQLPSQRQEELVAAIPRQILIKSMAFSYVFYHKRWRYHKLMGLTSPLLHRHIPCCGTPQAQALQPLLWIAVDQNMEFHGTVTKRERHLPRRFYNSQQLELDACAFPSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRD2</accession>
    <name>A0A088RRD2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_230130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699172.1">
        <property type="nucleotide sequence ID" value="XM_010700870.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22575217"/>
    <dbReference type="KEGG" id="lpan:LPMP_230130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230006100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_230130"/>
    <dbReference type="eggNOG" id="KOG1786">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF123">
        <property type="entry name" value="PROTEIN FAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="3">
        <location>
            <begin position="2027"/>
            <end position="2195"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="2">
        <location>
            <begin position="2209"/>
            <end position="2506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1526"/>
            <end position="1562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1526"/>
            <end position="1537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN98465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2859" mass="313837" checksum="FBC796C2DDDC790A" modified="2014-11-26" version="1">MLEAILPENVFSVAMTAVTYFSAPEEAGVEAADASCSILHQQLPNVQDADTVVKTLRAMEGALVSSQRRTSDSAAAVWSLNCFVYMLDSIIYAKQLVGFSSVESINFDVITATVLSFEKEVGESGMPALRRVVGSLRVLALADRPDMSSGQSANTSLLSSSFFRILPASVGRMQQRIVDSWGAAERRETPPDVRCDGAVEALARLFVLSTQRQMAELCGQQLFPLLFMRGVSASLLGFVLLICAEGAPCFEASKLCSLMTFVGTLPCRGAVGDFLHAILEHLRCGRLPLPEQRLLVVDFFTDWCAKASTNAAVSLALGVVQACVHCLMELAVDSRAGDLETFVEHFSVLAKVLLGSKEAADSLMSDDCSAALLQVMLSALESEQQHTAVLLRDVFVGLALKTNLSCDALLEQIASATDADAWTSLATPLLSTLVLLLHSCCRHSRASLPHKCIDLCLSLMQYVECGSQHPPVDRHLLGCCLSLLLTLVSYSDVWELVERALGTLPVNCDYVQCMIDLCTGVLRSSESLTVAERYFTAPVESKERWTVPCFVHFGPFAVMKEPCIEMLYPVKLLVRMVDTMLTDQHADAASAMEAMEHLMLHSGVTIPNSYVADFIARWERFKWIRCVSNVCDPQLLPLFFARTTTVATVQANQRVWLEALAENLASGEESRRYNDYIHFGEKGGAKGLLTCSGVTWPPLDAYTAAMWVYMEPISSSRYKERVALWELEWDAMGRHVCLSLVAHIERQCCLYRCDLGGDVTVVELPALPEHRWVHVATLHARGKMFASQIKMYFDGVEVARKGCPYPVGGLQTAAAVATSLPSLTNREVGLTIGSPLDTRRTDAILRLISFQLYGCGASVQQISSLYAMGPYPSSQVWDSAGQHVYDLHAPCLCDEVVRSVEASLQSASLESVLREQSVVLACPPTVCLVHVHALAMKQVNTVIGYLNNKQWALRNLAASTKSMLCLHGHYHPPLDTRTTTVDALLCNGAFCEWMRWMQCIAAGVFDAERARDSTTAMGNSSVSPEGAGESLAVVQQTAYTMLRVLNLIKAKTDLLPLSWHRFMVQFAEHVTRYPQIYLHHATTATQLLQLCLQTVNYRAKDLCAVDEQLLSNLLPLEHIFFNWRLLSNLPDDSWVKVTAVLRQLVSPSNALAKLNTARLLTADFVNGFVFGLLREYVAFPRLLTAIELVKCMLLTGQATEELMERVLMAIVLTVPGPNQGGANNTVESHLGSKLATTSFVYLVLARNMFLRCLNEVLEMTLNDGNGAFLATFVSVVPDWWFTAMLSGNSHPVSATLTLRLFVLCFLNSRPFRDACSATKSECISRALEPHCHQRELMDVLVHGYMGHLWALSSSHVGYSTEGWSGKREMEGLLVLILHLLKAQCQLLLRGTPVTSEEVTVRGYFSASAAQATSSMEGNVSPSAGRWRRVRLVLAALRRMRKAASDKKKVKVEGSVSCSLPVTQRTAPVSILKDLVCEVLDWLTQSYQLSRALSKSLYQSNNTVNLCDFLIWPVFVALCSKEPISVQPSAGVGSTSRTPAEEDDGAATPSSGASTGVDEEEEPWEVLSDITTYEARSFGLDSMGPAEGMENVYDACKMFFLTHARSRASNTSFLAISGGRTTMSKYVLALHRALSTEIKGASNHAEDARKAFLCFVWLKASEHAVDRTSNGNAAAVKRNAIELGKYMLDRLVSGGAVPPAAIASFYRFLLTQLERDAVVVESARTALFEWFMYVTSSSFYKLDASKVGVVVDMVYSCADMLFSYPIPAMELLKVVVGRLLQVTVCLWNSVADDDHPSIRKMAVLWKAVLCSNEKNAFVITLFMCGSPVVDTFHGGFDLLLPPIASPEAFTIWMRQHRAHVAQLLRSYMGLSYSFVMANGGEHLRLITRYTTASQAEWDRRRRHVAAMEAAQWQLWKDTFLTTTFVDSALLACTTRRYPYGYVLNGSEAAVDAEDGVCCEWSMDDSGAVGRTRRYVTENVDEASSDPLSFYIRYAPPVCLPLRRQEVQSQAMLLRPNARAVVAKVAGHEASGSVVFVSNAYLVLGTESYISTCILTQQALLIVTCSVVTAAGDFFVEQVRVHTASQNPHAKSSLLKQAFRLFMPGQGKTSGGTSSQAAFRYSQYYRQLQTESAKGSNALVWRFPLGSITSVHQRLFQHLSAGLEVVLECGKCVFLVLLDDELSFSKASRDKLFAHFDSGSNPLMSRIAVHPMSEKLARLGIWTRRWVRRECSNYMYLRVLNDAASRTTASLGQYPVMPWVLSRYTESTLDLGDAGAYRDLTKPVGALNEVKAKQLQARYAEWIACDPVADPPYHYGTHYSTAAIVLYYLIRLQPFTSRAIRFQGGRLDIADRLFHSVAEAWANGSGPSRGDVKELIPEFFRVSQFLENRNEVCLGTRSDGAVLDDVVLPPWAGGSAVRFVYMNALSLESDAVSQQLHRWIDLIFGYKQVGQGAVEAINVFSPLSYKEGVDRSINHAATEEERKSIVASADNFGQTPLQLFSRDAHPARKGVQQARTTQAYMIETVTDITTRPCLSAQIVGKAQGGISTVSIADGTLFICDRLSAVGLAKPLHLFFYDCDLDSIACTTARGDRVLATIQPVRSSGSGDVRCLCTSVRGSVVCVGTDSGKVIVYSRESCRHRFFIVAVLDSAVAAVLREAGPVSSLHLFDEGNLLVAYERASAVSGWHLSILSTAFTFAATFSTQADCTPVKAISLDNHTGLYYAAKANSLVIFSASGVMLTQLSMDALLMPIAPEHATRIADSSITALLFASCSSFAFTNLILMGHLNGTVSLWCVVASQTMTDETSSIQAPLWSFKLLHDVVFDAPVTCLAASTEELSFVVGLANHTAHYMYFPTSQLDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRL3</accession>
    <name>A0A088RRL3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">A-kinase anchor protein 7-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_241040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699444.1">
        <property type="nucleotide sequence ID" value="XM_010701142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRL3"/>
    <dbReference type="GeneID" id="22575513"/>
    <dbReference type="KEGG" id="lpan:LPMP_241040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240016400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_241040"/>
    <dbReference type="eggNOG" id="ENOG502S94M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277832at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019510">
        <property type="entry name" value="AKAP7-like_phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009210">
        <property type="entry name" value="ASCC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13360">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13360:SF1">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10469">
        <property type="entry name" value="AKAP7_NLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A-kinase anchor protein 7-like phosphoesterase" evidence="2">
        <location>
            <begin position="233"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="507" mass="55220" checksum="5A47E90D61DCA7E9" modified="2014-11-26" version="1">MAQLIMPPSSAQPMTKEDVAVVQAEKRVDAATREQLVKVYGDSRGLHGRRIALTRPPKREWKCTACGKQSNDIRHVCAYCLSPEPGYSNNSATSRPRHAGGPAKTEKVAGPRSFVQRPGTCKDAGVRLMQTSLTKRTYRVFTESHIPAAKPRAAASHRSATSANPAIAELAVEKGDEDMSWDDEPNCSDRATGGPCSPGEEGDSSDDDEEDVRSPAQDAQFRPPGAERVDRGFTHFVSLPIGKLPAVVANATSVLEDLRSFVASKYELTQQESAAAVGGATDPEETTASSFSKPTAASELVARTVKLHMTLLLLRLPRREDVEFAKELLHGPFVSAWATMKEKWAASKDTTYALSGAPSLAPTHRHPLVRLGGGLQVMRAGRQNALYHSEKASVVYMGIDDTAGLATVQQLQRVLHESLAELIHNPEEAEKSRRVLHVTIMNKKWCKGRAARRTFDAQSIIEAFPDAAIGAGEDGRQLFEIPELELCSLHRQDPENGTYLTETTVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RS70</accession>
    <name>A0A088RS70_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA polymerase theta (Polymerase domain only), putative</fullName>
            <ecNumber evidence="3">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_240870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.7" evidence="3"/>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699427.1">
        <property type="nucleotide sequence ID" value="XM_010701125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RS70"/>
    <dbReference type="GeneID" id="22575496"/>
    <dbReference type="KEGG" id="lpan:LPMP_240870"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240014700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_240870"/>
    <dbReference type="eggNOG" id="KOG0950">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2320933at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08638">
        <property type="entry name" value="DNA_pol_A_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000113">
        <property type="entry name" value="DNA polymerase theta, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002298">
        <property type="entry name" value="DNA_polymerase_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133">
        <property type="entry name" value="DNA POLYMERASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133:SF62">
        <property type="entry name" value="DNA POLYMERASE THETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family A palm" evidence="2">
        <location>
            <begin position="699"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="800"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="976" mass="107037" checksum="DE117A3F08A72B13" modified="2014-11-26" version="1">MPLFGTLLAGRLGPVAVDVQLQGHTRLLQHPQLFEAVLQAYERQSAGELREALRSVQPFFLLCNTGGAADMCMDHSEALGGGVDGDGHPQPALGAEVLYTMHPANGYPVLPLLAQLLRAPQVTKLLLHSRLLYRLLFLFLGTDRVELSSVVDLPTWTALGQQSRPSLALLFHLPMESVNRLSDIAAVLPSEAQQLLNEETESIAQQQPQEQQLPNQTRSMRLEDNSELDSLGEASTDDTNGAGDRNDGGEDEHDEGGSTRAVAADGAAEDEVVDAIELLHRIQPLAEQPLNSNCSRVSGAAGTDSASAARTAGRKRRSLRSHKQYRRHRYDSDMPLSSLADASTLADIYHGLKVMTLFFTHVLSRLLDIVNPGMTGVAAPRVGIGALPLTTSRCGSNVIGSPASAVRYRISPSELCALRTYADFLCELMTYHGVFVNDTVTHKMLTLLDVQMATIEDLGLRVAAALLATTDPVAPSTTPEEAECSKWNVGTVHRCLARLTAASTMFEIPRALNAHYLRLLAAQAKHSNYVRAAQFRLGCQLVCAWMAYLDRVTAKKRLHDMFSKVSDRLHLRVLEKPRDAAVEDDVAAPDAPMPQVSEVCYSIHPDWALHNTSTGRIFSALPNVQNLPKQPPRTAFPIHALSATQDRSSNGGGDESLRPYGYVDSPTEEDVDRWLSLAEAGVIDQASSAQFLLFPEHPQWTLRHLYCAPPGCVLVSFDFNQLELRLLAHLSGDSALQEHLSSNVDVLALVTASVLRLPSIDHVRPEQRQAVKVIVYGLLYGMGPELMDVRIRKINEEFATAEQQQQHDQEGAASSSDPESASARDLLRRFYHAYPRVESYLRETRQEAQNSLVVETLSGRKTLLAETDANRRKQRAIAQAVQGGAADVLHSAMRAVHQQRHSFLPYLPAAPLALVMSIHDELVYATPRVAIDEVVRGVQRILEDQARVLRLAVPLPVSVRVGHSFGELTEFHSARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSN2</accession>
    <name>A0A088RSN2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_211400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698926.1">
        <property type="nucleotide sequence ID" value="XM_010700624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSN2"/>
    <dbReference type="GeneID" id="22574962"/>
    <dbReference type="KEGG" id="lpan:LPMP_211400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210018600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_211400"/>
    <dbReference type="eggNOG" id="ENOG502S96T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="263255at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="247" mass="26128" checksum="92926F9D03501DA6" modified="2014-11-26" version="1">MSTTACLLKTKTKTKRLSKATQQTPATSTPSPPSLNTPHSPRLIPATTSRIKGAAPPPAAAAASSTTDSTPSSLSNANLAATAPPPAPPPPVAAHDAERPRRSYAPTSAAISEQLASLRRELLETRMQLAKAEETNAGLYEGVLARLAETDRAALLTASSLRYTGMALRAAHDNLEVELRRLLTIGLTAEEVDAAAIEAGARQYVRQNIGYHTEHVAVEPPAVPDMARGMERNERRDALSGFAKSPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSY6</accession>
    <name>A0A088RSY6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_220650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699066.1">
        <property type="nucleotide sequence ID" value="XM_010700764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSY6"/>
    <dbReference type="GeneID" id="22575111"/>
    <dbReference type="KEGG" id="lpan:LPMP_220650"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280038000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_220650"/>
    <dbReference type="eggNOG" id="ENOG502RZ2R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="260236at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053125">
        <property type="entry name" value="RNA-bd_mRNA_stabilization_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37035">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37035:SF6">
        <property type="entry name" value="RNA-BINDING PROTEIN ZCH321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="507"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="508"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN98359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="591" mass="62161" checksum="826D2A3B268A2745" modified="2014-11-26" version="1">MPRTAPTKGRHISYNADGELCMTVVDPVTRKLLIPTQYIFETRAQQRGTLPSLCQLFLAGRCRKGQGCYQLHADWEAVQRLRSQVDSLPCCCPTHGDKDHIGVLENAPLRESVSLGHPHSHHHANGDQSSADAAAVAESSIGANDVVLYVPGCSFFEGSYAPLDRVSYTLGLRRLLEEQRVVLAPPTARISLLNQSTGFPEEKVVADASAATVCRLHAMGRCRYAEECKFLHLCKDLTAADPQLTASPTTGGVNGTADCAAPGSFEASTTTTGLTSGTESSATACDRRLKGSLYHGYSGASTTVGGAPVRQSVFNSISLQQQLPLGNGSAMAADPAGVAAMVKAGSASSLQLSHSMSYPQDPSMIMLADEGAGSVHGSSRPYLMGCGGAAESSRLLVPQREDVSNGIDGAGSASAVSYLSKSFNGCRVSAVGTASLTQRSLAVESGTTPHMMNVCTVSFPNSGQQNNSMASAASYGFSSTKGSRVRVSLSLPGASSTSVLTFGAALGTPNSSEKTNSPSEEGALGMSMRSHHSFSRLVPQMHASSNPTRWHHNPYLATWPKTDAPHECISRSSTFRCHPDGFYARPIARAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RT41</accession>
    <name>A0A088RT41_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein kinase, putative</fullName>
            <ecNumber evidence="6">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_252070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="6"/>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699777.1">
        <property type="nucleotide sequence ID" value="XM_010701475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RT41"/>
    <dbReference type="GeneID" id="22575855"/>
    <dbReference type="KEGG" id="lpan:LPMP_252070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250022800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_252070"/>
    <dbReference type="eggNOG" id="KOG4645">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272800at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06606">
        <property type="entry name" value="STKc_MAPKKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="5"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="235"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN99070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="568" mass="60874" checksum="2AEC78C94EB86282" modified="2014-11-26" version="1">MEAVVKLNRKLGVGGRGVVYEGFDHARGHFVAIKELAYMEPSVADEEDTELAAILTELAYMREAQHPNLVEYYGARRSPIGIQIIMEYVSGGSLDYVLKRCGPVRETVARAYTRDVLEALHYLHKTMHVCHRDVKPANILITPDGRCKLADFGVAKYVEVMTPTHSAQAARDSQGVGKAEGSTSPRHRNDERQCYLQTAVGTPWYMAPEVINGGVEDDDDEDVALDDPYALTVGGNASNGSSSEDWTSSGLAHTASHPLASTPPLYSSSNYYNPLKRIVKKGRLGARSVGYTTSADIWSVGVTVYEMVTGTKPFGADLSNPSAVLFRIANCAASPPQLPAGMHVSVELHNFLDLCFVYDKDLRATAAELLGHPWLQPARKSSNRGGVSASGAKQPHRVLSNAENLSHSDMRVDECEPVQRHQQPATRRTVFDGVPLLDAIDLPAYPAMTAASSLVSSAATECGAGGEGVYPLPTSSSGCAQHSLHRLSCSSVPRGSPSILMSPPPSSVSIAEQAEASSRYAAVRQRIGHTRATNSARTAVSAAAPDAQSSAGILLSTYGEFVDLLTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTF4</accession>
    <name>A0A088RTF4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein kinase, putative</fullName>
            <ecNumber evidence="7">2.7.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_270550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700144.1">
        <property type="nucleotide sequence ID" value="XM_010701842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTF4"/>
    <dbReference type="GeneID" id="22576231"/>
    <dbReference type="KEGG" id="lpan:LPMP_270550"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270012300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_270550"/>
    <dbReference type="eggNOG" id="KOG0594">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="255890at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07829">
        <property type="entry name" value="STKc_CDK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000821">
        <property type="entry name" value="Cdc2-related kinase 6, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000611">
        <property type="entry name" value="CMGC family protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF417">
        <property type="entry name" value="CONTROL PROTEIN 2 HOMOLOG 6, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="24"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN99437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="328" mass="37570" checksum="C42FC3209CC64F79" modified="2014-11-26" version="1">MSTSVDDLNGKLDLVDIAALSAAYQPEEVLGEGTYGIVFRAHHKETGAKYAIKKLRLDGFSEGVPATTIREATLLHDLNDNPNVVRLLDVVCSEHRVYLVFELLDEDLRTFIKRYRPVSGQKPANGTAVPLPIVREFTRQMLYALWTCHNSRILHRDLKPGNVLVASYRDKKSEETKFYVKLADFGLARMFEMSVQTYTHEVMTLWYRSPEIILGDRHYTPAADVWSVGCIVAEMILGYSLFRGENWRDQLDKVFYVVGTPTEQTWPGVTKLPGYERNFKVYHVAPLPTRLRDYDEKAVEFIAYLLVTNPKLRPTIPDILEHPFMKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTT4</accession>
    <name>A0A088RTT4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphoenolpyruvate carboxykinase (ATP)</fullName>
            <ecNumber evidence="3">4.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_271790</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>oxaloacetate + ATP = phosphoenolpyruvate + ADP + CO2</text>
            <dbReference type="Rhea" id="RHEA:18617"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.49" evidence="3"/>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700264.1">
        <property type="nucleotide sequence ID" value="XM_010701962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTT4"/>
    <dbReference type="GeneID" id="22576357"/>
    <dbReference type="KEGG" id="lpan:LPMP_271790"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270025800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_271790"/>
    <dbReference type="eggNOG" id="ENOG502QQI5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="274702at2759"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004612">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00484">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.8.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00453">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001272">
        <property type="entry name" value="PEP_carboxykinase_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015994">
        <property type="entry name" value="PEPCK_ATP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00224">
        <property type="entry name" value="pckA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006820">
        <property type="entry name" value="PRK09344.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006821">
        <property type="entry name" value="PRK09344.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE (ATP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01293">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006294">
        <property type="entry name" value="PEP_crbxkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="PEP carboxykinase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53795">
        <property type="entry name" value="PEP carboxykinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00532">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN99557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="524" mass="58494" checksum="CC3FEF08801273AB" modified="2014-11-26" version="1">MAPIIHRNLTAPELVQWALKLEKDTVLSARGTLCVLSYAKTGRSPRDKRVVDTDDVRSNVDWGSVNMKLSEESFAKVKKHAMDFLNSREHMFVVDCFAGHDERYRLKVRVITARPYHALFMYNMLIRPTQKELESFGEPEYTIYNAGECSADPSVPGITSKTSVSLNFKTQEEVILGTEYAGEMKKGILTVMFELMPRQGHLCMHASANVGKKGDVTVFFGLSGTGKTTLSADPNRMLIGDDEHVWTDRGVFNIEGGCYAKAIGLNPKTEEEIYNAVRFGAVAENCRLDKTHEIDFNDESICKNTRVAYPLEHIPGALTHAVAGHPRNVIFLTNDAFGVMPPVARLTPEQAMFWFIMGYTANVPGVEAGSLPVAKPVFSACFAGPFLVRHATFYGEQLAKKMTEHNARVWLLNTGYAGGRADRGAKRMPLKVTRAVIDAIHDGSLDREEYIVYPGWGLHIPKKCARVPSHLLDPRKAWKDVKAFNHTTKELVMMFQESFEKRFASKASDALKSAVPKYVECAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTY4</accession>
    <name>A0A088RTY4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_272180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIM50 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700304.1">
        <property type="nucleotide sequence ID" value="XM_010702002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTY4"/>
    <dbReference type="GeneID" id="22576396"/>
    <dbReference type="KEGG" id="lpan:LPMP_272180"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270030000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_272180"/>
    <dbReference type="eggNOG" id="KOG1605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000282">
        <property type="entry name" value="TFIIF-stimulated CTD phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="74"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="287" mass="33446" checksum="283D225FCBDC5284" modified="2014-11-26" version="1">MYANKENAWDGYTDDRFYGAKRFREYWQRMLADRGVRYYIFTIIVLMMAATAKLWQMQSLQREESGLLGPRKKQYRSRLTIVLDVDETIVSYGDKAFRLKAGLVPRPYLAELLDYLTSIDAEVVLWSASSERYMRQVLGVIDPTGVRVSQYLARGREWFTHDNYYEKNILWLKRPLENTLIIENRPLSVRNCNGNAILVDDFIRGEYMDTGQDYPANDHALRTIKNIVQDLETSGMSVPEYLANHKVRSRAIKEIPCHLAIRQLPEEIARGVFYFIGDKYKAKSDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RU67</accession>
    <name>A0A088RU67_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_280040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700349.1">
        <property type="nucleotide sequence ID" value="XM_010702047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RU67"/>
    <dbReference type="GeneID" id="22576449"/>
    <dbReference type="KEGG" id="lpan:LPMP_280040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280005300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_280040"/>
    <dbReference type="eggNOG" id="ENOG502RQ5Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938:SF35">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938">
        <property type="entry name" value="RESPIRATORY COMPLEX I CHAPERONE (CIA84), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G06020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="245"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="910" mass="99627" checksum="078EAFA24A0C0191" modified="2014-11-26" version="1">MPPPYKKPISGFAAAAKVLFDSAQRVGAVQPLEHSAKQYAQQLKKIQSHSKKRGGSLGGVSYKVEEFLAAQRAPIPQQARPGQPKERTIAKRVPLIEIPVITAKATAARTPATERERGLPLGPPPSLTSLFATKTELHDVAAPASPSLLPPTAAESTAPATPPVEEVFITEDKPLFEVRQQVVPLPSPEAVIQPAVVCAKLQDASTHARKVKPVISIPIASVSTATVEAAAEEAVGSSATTNFSVDAWEQQRERELQQLQKKQEEEELQRLAVVREQEHETLGKEWVKRRTYKVSFEAERTAVTELLGELFVADSANTALSIFQKMLDFGTRASALLPAALASVAYRIRAAPPSERRDLKRVLLDAMEKAKLPDHVVRKAHLLVSGGTDFLAAFGALTAEEKQHLDSRIILRAIQILAWNGRWEDALELAKRSRSNFRSGSDVMDLALLRASQLLEEGPRKELVTYATQNLTESGRLGVQAKLLIATSERGTYRRTLLKQLTASSDVDESIYAELILRSDKSQTEALLAEIAARGLNKDDPVVLGAVAMKALNNELPEEAFKEIHRQVAKIGLQAIHVRVATMTAAQHPTEEVLRQASAIVQMAAPVARGPGLRKLLPILYEQNMLDEIVHLADSTNESVPLAKLMPRAVAFVNEALLKVGRKPLSDVRVSDIGFSRLTGGTAASLPCKLDDGRAASVIADIAGLTERMLLYAKEQQWSEALEVVKGLPTAIKADASAVTLLYNCALSAAVEHPERVKDAYALMGSRRVKVNATTVNTVLSSLSKSSIWREALEFFNATPLEQRDNNTYLVYFALLGKHNLWREAAEAYDKTRMAIPKLPAAMFSLIIGTTRGHDWQATLRIFQDMLKSYGAGVKDSVVTQVIRCLEENSRTAEIAKLEKELAKRKKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUA9</accession>
    <name>A0A088RUA9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">VPS37 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_280580</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS37 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700399.1">
        <property type="nucleotide sequence ID" value="XM_010702097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUA9"/>
    <dbReference type="GeneID" id="22576503"/>
    <dbReference type="KEGG" id="lpan:LPMP_280580"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280011200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_280580"/>
    <dbReference type="eggNOG" id="ENOG502RZZB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="243464at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009851">
        <property type="entry name" value="Mod_r"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07200">
        <property type="entry name" value="Mod_r"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS37 C-terminal" evidence="7">
        <location>
            <begin position="135"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="169"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN99692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="286" mass="32142" checksum="E0AE9C2680AC2D73" modified="2014-11-26" version="1">MPQDRSEQLEELRRQFPSTSVVTESAQETVLKVDHALRISPTIEYALSLYVTLPSSFPKAAPKATMPYCCHNVPITPPNINPSEAMAYQWSVATSTLVEAVRNAFQNAADCWGPVEPPSLHSVTLQLSGETDRLLRDLVINPNCLDAYCYQLPIVKLMRKVSRQTMSEIERVANENTTLRNEVETLEAKVKGLQQRIGEQVSQLQQLGQNPLLTSVGTPEALIKTLEDDVRKMSRDCMVLGKRAMDAYKVDKGDFQDLLDQYKAQSKEMHILDLKRISYRAQCTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUR8</accession>
    <name>A0A088RUR8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Pre-mRNA-processing factor 19</fullName>
            <ecNumber evidence="14">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LPMP_272510</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the WD repeat PRP19 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="14"/>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700337.1">
        <property type="nucleotide sequence ID" value="XM_010702035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUR8"/>
    <dbReference type="GeneID" id="22576429"/>
    <dbReference type="KEGG" id="lpan:LPMP_272510"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270033200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_272510"/>
    <dbReference type="eggNOG" id="KOG0289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="687049at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070534">
        <property type="term" value="P:protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16656">
        <property type="entry name" value="RING-Ubox_PRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000027">
        <property type="entry name" value="Pre-mRNA-processing factor 19, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038959">
        <property type="entry name" value="Prp19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013915">
        <property type="entry name" value="Prp19_cc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055340">
        <property type="entry name" value="RING-Ubox_PRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08606">
        <property type="entry name" value="Prp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 14" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11 14" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="13 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 14" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 14" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="U-box" evidence="15">
        <location>
            <begin position="2"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AIN99630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="516" mass="53155" checksum="12A3CB4871CED131" modified="2014-11-26" version="1">MMLRCNISHQVPTHPVVSVRSGLVFEHSLVEKYVDEHGRCPITGDPLCKEDLIAAHGAAPDVSIAASGNLGAASVPTLLERLQVEWEGVALEQFSLRQQVTQLQLELAHALQQYDAACRVIARLSKELDSHRGGKAMAAEEADQGAAAVMVPAAVLRCVDATEAAERQGRKQRKASAAASSAAALPLQLTEEAQWVAASSPSASASSARSALRVAAAADDSSSAVFVSALTGDHAIVRYSPNGISEEARGVGHTAAVHTLASQLGGVLLSAAEDQTVRVWSTKGAGLTVMHTLRYASGVAAMSQRTVGGAYVLCGAADGVLTLSDLESGAHVVVTAPLTRDAASPTLTCVELHPYSSLAAVAFQRTELQLWDTREMRADTSISHVRGAAAHTHICSATFGADCVSLAAGLTDGSVCVWDLRQVLAPVAVLPPSPDTVPATVRYAPDGRSLVVGGHGVALYDCSLLSASSTSVEAIATAGLKAGAVSDVCWTTSGADVLCGTVDGVVRLYSTAASTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUS0</accession>
    <name>A0A088RUS0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">EF-hand domain-containing family member C2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CARP4</name>
        <name evidence="10" type="ORF">LPMP_251510</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699721.1">
        <property type="nucleotide sequence ID" value="XM_010701419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUS0"/>
    <dbReference type="GeneID" id="22575799"/>
    <dbReference type="KEGG" id="lpan:LPMP_251510"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000019900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_251510"/>
    <dbReference type="eggNOG" id="KOG0043">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10255210at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.170">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006602">
        <property type="entry name" value="DM10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040193">
        <property type="entry name" value="EFHC1/EFHC2/EFHB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12086">
        <property type="entry name" value="EF-HAND DOMAIN C-TERMINAL CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12086:SF11">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING FAMILY MEMBER C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06565">
        <property type="entry name" value="DM10_dom"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00676">
        <property type="entry name" value="DM10"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51336">
        <property type="entry name" value="DM10"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DM10" evidence="9">
        <location>
            <begin position="100"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="DM10" evidence="9">
        <location>
            <begin position="276"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="DM10" evidence="9">
        <location>
            <begin position="455"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN99014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="773" mass="88598" checksum="908D5541A8AB83C8" modified="2014-11-26" version="1">MKNSVARTQPEKHYAHAPQSENLPLAIGANFHDDPINRSTLRKSHNLLLERKTDYAPHTKYCYSGQPFERLHTAAEAAAEDEEAVWNGWFSEDFTKEDLDNFVVRMLGYFTEDVSESSAEKERVRKVCISFFVKDDSLSITEIAQKNSGLGESKILSRRQVPKDMRNPNDIFLLSDFRVGDSVSIYGQTYYITDMDKRSRRYFREVLEKDIPDALSIPQDSFTRTAAASAERSTKRVMTSDDMDRKRAIEQQLTGIYTKHSTEDIAITKEFLKNKINEHLTYMALWDDRGNISGDLHYCVIRVYLENNIIEIAECRPENSGRWGGPILIHRQRIPHPSADLTQSRYQQHTYGKLMKNDYLCPEDIQVGETYVIYGKPFYVYDSDAFTRNYVREKYQVIIKDAVDIAPFGTLEKRTSVFYPPPPNGFGSERETRSNWLSLVGKPARIDHELAQRESGRVMSFSAKLAKPIVAGDESREFVISFYRETKELAIFEKPKRNSGMLGGRFLAKGAHRKDMPNGTTVPFSADDFQVGQVIEIYRRPFLLTGLDAGTQRILDGTDKDVTEDRIKCLVVLLKQQLNLKFTRSSEAFLGLAPQGTLGYVQVKEFLRACSCNITDEEALLLVQNLSPGTDGIISYEDFRQVVDVSSESMDEASLTTRSIRNVNMTRNDQLKSTATVSEEKLRRKQLRDVLQFKLIQRKGSVQEQFRLLSDYSANSRLNRDMFRISLNTVLHFNMSKEDEDTLVSLLFDNVEDENGDITYKQFQEFVDSVDNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUZ7</accession>
    <name>A0A088RUZ7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein transport protein Sec13, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_280660</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700407.1">
        <property type="nucleotide sequence ID" value="XM_010702105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUZ7"/>
    <dbReference type="GeneID" id="22576511"/>
    <dbReference type="KEGG" id="lpan:LPMP_280660"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280012100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_280660"/>
    <dbReference type="eggNOG" id="KOG1332">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="364224at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090114">
        <property type="term" value="P:COPII-coated vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF2">
        <property type="entry name" value="PROTEIN SEC13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN99700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="358" mass="37956" checksum="9E1EC868A633A756" modified="2014-11-26" version="1">MSDTLLDTGHLAAVTDIAADANGRHLATASSDGTVHVYESVTTAPKEASQYKGGPQPTTWNPVAVLQCSGEEQAATVTCVAWAPPVFYTAALVTCTEASNEVALWCDVCNDAQYRKIYTYTLATPGWCVAWAPHEYGKLFAVGCADGAVVVFTGGPDGTWDIRSFESHPHGCCSLSFAPFFPPGALLMAPLERDLSNVPGNAPPMPFAPPRLVTCGGGRLVKLWTHSFAPRSGEEGSGAPESVWVSMELEAAEALSTPAWREVSWAPNLGLPFTYIAAGSEDGMVAVWVQDGPASNPWQCRLLPPPHGTPGVNVTKLSWSLVGTFLLVSYADGAVAMWKETGNNGAWRVVSELENPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RV53</accession>
    <name>A0A088RV53_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_290920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700700.1">
        <property type="nucleotide sequence ID" value="XM_010702398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RV53"/>
    <dbReference type="GeneID" id="22576856"/>
    <dbReference type="KEGG" id="lpan:LPMP_290920"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000044400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_290920"/>
    <dbReference type="eggNOG" id="ENOG502R9DK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="420046at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051961">
        <property type="entry name" value="Fungal_Metabolite_Diox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37563">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G03330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37563:SF2">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G03330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="350" mass="39672" checksum="998E08348C9F431B" modified="2014-11-26" version="1">MRIPLAIEHTTCSRCGKVLREATLKKSVHCVKCNRWYHRMCFMADTGVVEEKAPTTHSCVCCLSGTIEEKLEKHPHHMNKYAKAFLEDGFCVVPLAEKRIELDNIIQDLTAWNADLLRYFNALLKTYQCQAEMGDAVPTLEIGYSNFRQRCPGRFEIIADFITSKVVPLVAKSQIVQQTLDTLLCNAHLRIEKKVMSSGCFLSLMGSETQNLHTDGPGLSNAVNLFPYAVNVFVPLISVDSRNGTEFFPGSHIVGNARRRKPVSPAVALGNALLFDYRVVHRGLRNAKIDPRPCYYVTFSQSWYQDIYNFSRKRYKRQLDVDPSLLESREERMAKKRRSGDGGSSVLQLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RV72</accession>
    <name>A0A088RV72_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_281820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700522.1">
        <property type="nucleotide sequence ID" value="XM_010702220.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22576627"/>
    <dbReference type="KEGG" id="lpan:LPMP_281820"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280024600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_281820"/>
    <dbReference type="eggNOG" id="ENOG502S849">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267027at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="165"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="505"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="704"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="808"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="996"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1288"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1373"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1441"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1548"/>
            <end position="1579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1634"/>
            <end position="1654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1697"/>
            <end position="1750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2132"/>
            <end position="2158"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="662"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="522"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="592"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="817"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1015"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1293"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1445"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1459"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1548"/>
            <end position="1563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1697"/>
            <end position="1711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2144"/>
            <end position="2158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2179" mass="231482" checksum="BD48409A0B3847DD" modified="2014-11-26" version="1">MSANAPGGVVGRLHNRDREMPNQNAPHSVPRFSPPTSRQGSSTCNCSVDLDLSECGIQVAAATSGRHCSEKAKAGEVAAAEVDCMVAKAAELIASAAPPRRKLRGHNERAAQVLAQEHSKLLLLVGRRANVEADIEDLLELADAAREKVRQERLNLLSMPTTRATSDVAAAPLGDGTNSRHQDRGGGHGVDRGTSASSLDLAAVRYQLRRLSNDLLRNGVTELDATQLRQLVQELEDHLYLVEEALEEEAGNVEAIDPEAQSLLMTAGTAAAAAVPPPDRSLRQRLQHAKREQEDLLEVSSNLAHMKWLMESIDTELLTDMPQSQPAGTHETRAIGAGTEVGKEARGGSSWTADEETAAAFVHHTVCQSISEGALSCLSPTSMTTATAREWDKAELDPHECHSVSLEATISEPSMVPFSLTDLTANSKMSCISMATPMPAFSVKRRSRIGPKDTSAASPTPTAHSHQLNLLTFMSEVLAQYELEQVDAARLLKMRPLSAPSMRLHHQQASLVAERDRQQELDGAEDVEEDLGETVLQSIGMSEEDGRNRRSAGVSASGARRPPSSMSGAIPTAGGRLQPSSADNLSEELHHSSSATRHGKRQASSSTSRAKKVLLRAQLRDLRSGLLHDLHELCSLHNYVHLIETRRRELTEGIGKGDAEYAAEVEQKLAGHRLQLEAAKRAREEAARCKGEAAALTQVWGQDDIKSRTGSGQRPGASAGSQRTVASEDGQYKRPISAATLQPTAPSGGACQAGETAPTATVLHDAATQSKLAAEEAVTASVETELLRECLVDKGIAFTVVGVGRKRRNSAAAGSVTTEAGADTGAAATHRKTRRGDHDVTLGGASGPDSFLYYELRVEKPLSITPLVIPRADGATSDPTPAPASAKPVAAVVQVSARRLMNLRMTVEAGVTVEEVVTGNLVTRSVTPGAPPQLLLTLTPVKPYKAVSYAHAFSFSAADAFGGVEQHQRPSHNMWEGDSVASALFALPDGDYRRRDEARSSSLDSHNVRPAKLTPITTGSAAHDSSSTSVLSKKGVAGKKGFNARTKTAPLKGSGGSSKSPGRQSLERTRTLNLSTRAAMADVKRVKRRARQGTSGSLASLAGAGSTDVAATALAATTPINATGASNATLPDTAAVAVRSSCSAFKASQPSLATPMQLPCSPPLSFVPQPIDEWGVPHAHAEMEAVERNAVVLTVLQADGVAAAQKSERGGAGTSAVEQLLAAIPDSAILSLGEGWPSSGAAVLSSEGAEAREMAASPGTTDAGASSALDAMAAEILCQTMMDGADDEGGAARGSAYAKGGSASSGGFRDGVGEEGSTDPARLATEAEMAGVYLCDSSAFVDGEHRSSTSRTGSHEIDRHVLPLFLATDLDASQLSSSSKQHQEKHGEVEQATTGRVSDERYMLGASASRSFLVSKSTQPPVAKPETMLKPLLTPLQPGLLPVQGVTNDGSAADRSTTPPLPASKPHPPHTTPRKEKPYHRFATKSSAACAPLLRPPQSEPCCDEAELVTLMPPPVVVVKRTPGSTKPYMLLPPEAAVNLLGPSLRDPVHERSVGSELERHTGGQDSSVPGDTDAPHGLIDTAPISLPSPLVAAHSVLPPTGAAAAAAADVKTVSHVHKFLQAIKGEFPLHGTAGGARVSPASNERSPQAARGAAGLTVRTELGQLQEDARELFMMDPVRYDTVISELMKQVTHTLQQEFAPKTSSSQPTARGTGRVAADAAQTVSPSSPLPALDAGESPAGDATDALTGSAATATPASLAQARDFRTSLLVPSMLVPFEAPAEDGNARGCGLRASQLHLSSVIEKKQGSRTDGAVGGVSVVSPLLSHAVSRSTPNRLSQAAAAATTPGDVGAGADQLVFSTASVPPQPGAQRRETHALVMKDGATDQATGDRRASYADAAAEVERILYEQMKAQLLLRAIISKMKELWQTKQQDAEARHRERLANRKQRLMKRALAAIWPLERQRMIHLHKLIYLLDRQVGRVHGWLPHYSDSNVLIDVLPRGPLSRNPGCATLPAVLTGTHACLASWYRQRDQIKLDAAQDVDGVSAGHVCPRYLHYLPQRRMYHYMRLAKERRMLPLRLVRADIHLSHSRHLLLGYEKVALEGGGENKANRGEGRRLDGWPQRRLPRCRRGQPNGYAPPFRENRYEDMQTHGERERYRRRLQRTATFQSVSKMYSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVM6</accession>
    <name>A0A088RVM6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Treble clef zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_292210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700825.1">
        <property type="nucleotide sequence ID" value="XM_010702523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVM6"/>
    <dbReference type="GeneID" id="22576984"/>
    <dbReference type="KEGG" id="lpan:LPMP_292210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290024200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_292210"/>
    <dbReference type="eggNOG" id="ENOG502S0VF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="248294at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025487">
        <property type="entry name" value="DUF4379"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37317">
        <property type="entry name" value="BLR8090 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37317:SF6">
        <property type="entry name" value="ZINC-RIBBON DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14311">
        <property type="entry name" value="DUF4379"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Treble clef zinc finger" evidence="2">
        <location>
            <begin position="213"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Treble clef zinc finger" evidence="2">
        <location>
            <begin position="283"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Treble clef zinc finger" evidence="2">
        <location>
            <begin position="356"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="424" mass="46385" checksum="EA6C6280E3A890CD" modified="2014-11-26" version="1">MSARHSSTPLRSSLVTSKQVDETAAFFDRGNSSRDEAAESVDKESEGESEGLCPSPSARWKRASLRAMRGRDSVPRLAATEARDDADEMDDIGNGGSDEFSEPPTEDPVVATLHDEFGGSDELERDHGERRSRKGTETCLDGVSQAEEYDGAALTRRLRRRSLTASAADTDAGDADATSTASLPAELLQRTADSAVVDEEMANRYLALAFPELAAEYAAAGDGANTTPVSEVMTDSAVVAAWRCSTCNNVWRSGVFVRCILKNGCPQCAANRTSTLAKMRPDLLQLWDYNRNNPFLKPEEIAADSKQSVFWRCPMCRESYAARVKDRALDKVRCSSCALLRSQSAGELASEESVVLQEWHPLKNGDLRIEQLSPTDTRTKVWWLCAGCGHEWEASLAARLTRGRLRKRSLCPACHGKGVTELLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVU0</accession>
    <name>A0A088RVU0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome p450-like protein</fullName>
            <ecNumber evidence="11">1.14.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_270090</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.-.-" evidence="11"/>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700096.1">
        <property type="nucleotide sequence ID" value="XM_010701794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVU0"/>
    <dbReference type="GeneID" id="22576185"/>
    <dbReference type="KEGG" id="lpan:LPMP_270090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270006300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_270090"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000248">
        <property type="entry name" value="Cytochrome p450-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF43">
        <property type="entry name" value="AROMATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="523"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN99389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="592" mass="67186" checksum="DC94E815B1771ACA" modified="2014-11-26" version="1">MAANVLQSYIVAGLHNAAAKLPSSAQPYAMALMREDMISTTLATATVTAVILYIVITVVLPGMRMDFYLSKLPTVKNGVPFLGHALLLAGPSPWSKMSNWSLYPEKNLPQKKEDIDAPQTSRLVTYNVAGMRVIYINEPRLLRRVLLTHQRNYRKALAAAYKHFMCLLGTGLVTSEDEQWKKRRLLLSHAMRIDILDSIPEMTIRAVDRILQKLDAVGANNPFVDLNEEYRHMTLQVISETALSLSAEEADRIFPTLYLPIVHECNRRVWAPWRAYMPFLHGSRERNHCLSELNKALRDIICSRWEQRKDSKYAKRPDILALCISQIDHVDEKVIVELIDDVKTILLAGHETSAALLTWATYEVLRHPEICQKVLEEATRLFDPARCTERVQTRYGPRGVPAVADVRDLVWTPAVLRETLRRHNVVPLVMRYAAKDDVWLAADTGLDADVRIPAGCTIAVGIEGVHSNPDVWNKPEVFDPTRFIDAEIANDSNYLNQSSKDVKFTKKIDPYAFIPFINGPRNCLGQHLSMIETQVALAYMVLNYNLKIYRDPSYKGEIVAYEDSVGRHHDFIIPQVPHDGLKVWGTPNKLFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RW11</accession>
    <name>A0A088RW11_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_270770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700166.1">
        <property type="nucleotide sequence ID" value="XM_010701864.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22576253"/>
    <dbReference type="KEGG" id="lpan:LPMP_270770"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270014600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_270770"/>
    <dbReference type="eggNOG" id="ENOG502RSIC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9974723at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="822"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1229"/>
            <end position="1253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1340" mass="145985" checksum="6045BA030A8D8374" modified="2014-11-26" version="1">MMAGSPKLVLGSLHNISERSIFFIPLENDRLDLKTVSTAPPSHRSVLQRNGLVAKVCVGVTLYEAWAPTTSPPSYTSPGGETCASDAADSVGQHTLSAARREELCRSALVYAGLLHDRWDGLVIPEEFAATPWPVHTEKQYTELMEELMIRKACATVNTSGFCVPVLSIDEFVYKHKGVRVCLGVTWMPRYPQNLWQWAAQFAQSGHRVPEASLLALLHHVTAGALSLNTAISTASRVNATPSLFVALEKVLVYPAAEVVKRTANKADSDEVGRSFTFVLSTGAFKWRQAEPYPDKNSERNATAHFCKECRINHVIVPEAKLLLYRPPEDCSPEPYPTNGNAAAKRVAWELGVVIYLLASGVAGTGNATAVTSPCHRSSRCVRLRELAPLNSADHTPDSLWKRLRQELERRGYSSTIVTVVAQLLSLDPLTRPSLNTVDHMLQELQRPTPVRRFPFALGSYNLLRMPNPTDVSLNPGARRYTMEGRCVLCKRQRGSTASCAKGSDHIPGLSSPSWSDEELLPQLPGMHSHYITFLYPLCGSSDARRRRKLVALALQIPHGSTKASSSIVRDTAPLLDSTLLFQVFGGFAVYERVLDLNTKGQAFYRVTVREVLVPYPSEGLRRSELTLVKLTIDFCGGLPWPSSCTEILQKSGRVSRSAPLGFTGAQHDVEWFGWVLPGERFSLPNGGHWTAPRDGAFVFWFSSDLRPTDRDRYFALTSLRAATLAATLSRTVMPDSLFRLHAGDKGRVGNLLGGRVVSVTRPSACLRRFSVLRGSILHRRSCDSVADIVLPSTTREIVEEGEKMDTLPAHGLLSLYALPVQNTPEEPPSNGRRRPSSIKNRVPSRCTAAFPAGVIDAVEATAEAQRRSDATPTLSLFRLARGTSYRDTPATHPLHHPGRCFETPRPDACARADRTKSLSPDLAETCNQTRLTERNATQLPVYHDASANRARAVAAPEQSTPPAVSHSLISGRKKTCELHAMTVSFEELRDAAVVQSQAGAPLSVVAERPVLSAIALAQSMPFTQSISRRGSPRPLKLRTVAYCGTGEVGIQETSSATTPKLPPISGAQSAGLRDMHVNGVWLPSETVDATFRALTFCVLATGEHGYMHPPVKISTGVAHAIRALPGAAFLSFLSNQVPLLHHNHPQLDAVALSLMLPHHGFTCYAADGTLLGVLALRCSTKTDPDATAGEFELVTHASATCRAKSDALRTIYASYVAGNVGAEAHRRRVSVSASKARNDDGTADGEPSPLRHMSYVPHRASGNRNRWANTPENQTLSFTSARPLVGDFTPSENGDISLSPTQGTDMALPACWMDFDEASTALLFADAEQSMWVPYRIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWP1</accession>
    <name>A0A088RWP1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DEAD-like helicase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_301360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701166.1">
        <property type="nucleotide sequence ID" value="XM_010702864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWP1"/>
    <dbReference type="GeneID" id="22577190"/>
    <dbReference type="KEGG" id="lpan:LPMP_301360"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300018600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_301360"/>
    <dbReference type="eggNOG" id="KOG0385">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0386">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272877at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="280"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="753"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="544"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="596"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1041"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1094"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1158"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="554"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1056"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1163"/>
            <end position="1172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO00366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1236" mass="134170" checksum="36FBAE1559B602C5" modified="2014-11-26" version="1">MTTAARQAVLRSDMEVFMGAVAHQESMLDSVATACRAHLITDGAAATAPPACLFFSSLPQIPIRQWAGSHLYNNWFVRCQTPYALGPSAAAKPKAMRLHGAPMLKPSTASRALPKALVLPLDVEVELRKYWRLHDEAAARARLDALRCNDAEAFAKHVSLLKVSGLLKIMEKTEGFMRRIGLRLQAHSTQASANGGGDTTSAVTTTRVASAALDEQGDADRPGGAVGLRGSEYERFRAYVASTKNEFKLIHRVDVFVAAQPAGLDATLLPHQMDGLRFLASLDANHINGILADEMGVGKTVQTLAFLVYLKNRRIETAEASGGRVAPPLAGPHLPHLVLAPLSVVREWQEACEQFVSGALRVAVYQELADPVREAAAYDLVFLPVHAARYVGAEAARVQWHYIVVDEAHKAVANLNTITAQCILSLPCSRRLVLTGTPLSSDLQELWSLLHFLNPEVFTDNDAFEEVFRRPFRVYEAQEMELTAEERGLLILRLHQVLRPFLLRRTKADVDSTLRMTHHHIWCPLSAMQQRLLGMLREQRRTPTVLSMTRGHKSNSSSSSSSSSEAGRDDEEEVAGAADEAPHTITLPAAEIGADASAGCPGHTTAAASTAEAPHGKALPALDTLKAHNEASAASDRLTELVWQYLPALAYTEARDTVRCAVQEDRALGLTSAGVSELTSQLLCNHAFLLPFFSQVLHRHDLDEVTQEGYNNADSVAAVASQSCTLGAKVAGRCGAAGLTLACSGKFLILHLLLARLYVAQHKVVLFTHWLDCVDLLVDYLHSRGWADHTEVLTGGSSEAERLASVRHFREDPACLFFLISIKAGGCGINLQVAHMVVLVDRDYTATNEDQALARVYRIGQRHAVRAVYLATTDPSEERVAQRAATKNKPREAIINDGVYQVTTASEAKRAGETDESVTAAAFVEPPSHAENDLDACELWRSVPGATTPPSPPPEAQETLTPACDGELQGAAGSAAIPLPQPESFWLALSRLICSMDELVITEADRAAATVRSAEGASPDLGCAASNRVVARLFATRPPQSTAELQARLQREAERVPSTSPPSVGTSPSLSSAAAGGALLGARRDQAEALATGVYPRSDASDESQAVTLAEQPHSTPPSAPAADPLRNSSLFWLEYSYLLRIAERGPYLLSDALRAAASNDAQKNDPEEQVRRRQRRDRRTAKRLRLASVDVPDGFREACWAKESIDDDTEVAKRYLRFLDARAGKRRQRRRKDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXD4</accession>
    <name>A0A088RXD4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_310090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701401.1">
        <property type="nucleotide sequence ID" value="XM_010703099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXD4"/>
    <dbReference type="GeneID" id="22577435"/>
    <dbReference type="KEGG" id="lpan:LPMP_310090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310005800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_310090"/>
    <dbReference type="eggNOG" id="ENOG502QWT8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="298589at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="492" mass="56241" checksum="8AE6D1842F5042DB" modified="2014-11-26" version="1">MSRAHKGHTWMKNHPLEGDDVVTGLYNIIAKRNPKTMKACHGIRIPDTVVFEHNFPRGWYTTDMKAKEVVRKQGKELDAKTIEQGFTQDLHEGSPIAAIYLCTTETVTNEGETEVNTLVEVFNCDKLAAFLTRKVKPDGILQRFILPKGYHNSVIKVVWSPRVCMVQRRTNKYRIFDRKRAECDPFSITVTYDGPTFLSDEGSVSGNIALEVKQLCGNIVQHFYYTEHKFITRMVLYFKTDQRDRLWLLWCGSLRVSDRNTPSEMPVNLITNFAEPSLIGTAFDEDTLLRSADEAFIRLTNDEMFYETYMKRRQDSGAAHGETDMQGDKPPSSSTDTQQESHVNAAAAAETFDWSGVPALVLETRSRLLLEKKAMCSLFEDLFYHARNHFLAHRSEPYKMDVPRYAAHTLTENGIVDLMRTLRLPAVVQQPTASVSMHYIIGSVPRQPLTQLADKAQEWIQAYFDAKLQRLQQTVLHFTGDEDALRSEVMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RY95</accession>
    <name>A0A088RY95_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Electron transport chain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_322340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701918.1">
        <property type="nucleotide sequence ID" value="XM_010703616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RY95"/>
    <dbReference type="GeneID" id="22577975"/>
    <dbReference type="KEGG" id="lpan:LPMP_322340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320029300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_322340"/>
    <dbReference type="eggNOG" id="ENOG502RXBH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275715at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Complex 1 LYR protein" evidence="3">
        <location>
            <begin position="10"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO01118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="206" mass="24318" checksum="203A2341474E0A7B" modified="2014-11-26" version="1">MSALVPRDAVALLYRRYLKATNRIPNVTIRMLLLQQIRTGFRRNRSITSVSAQRELINQAHKDLTVLEDDRLSRTLYINRLGLVSCLDWEVRRTEYNFRPETQSYLAAFLICGFMFLFIVFLHTEKLETQRPDIAQMVDYMAMRLEAESPEELKEIRERQIRNSLEQRQHQVSLEQRVLATFYNSPNAPPPSLRNPEGSLRYERQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYD1</accession>
    <name>A0A088RYD1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_321280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701814.1">
        <property type="nucleotide sequence ID" value="XM_010703512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYD1"/>
    <dbReference type="GeneID" id="22577869"/>
    <dbReference type="KEGG" id="lpan:LPMP_321280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320018100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_321280"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF27">
        <property type="entry name" value="PENTACOTRIPEPTIDE-REPEAT REGION OF PRORP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="203"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="238"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="801" mass="90470" checksum="EB132B1D10850943" modified="2014-11-26" version="1">MYLTKRPPAELIIRRPNGTEDRFLQPTAAVVEQAACTATNDDHDATYQVVMECAPYTASFNALLAKQSVHEDSRQLVALVHHRMHSEGIPLNTQTYNLLMKRVVRFTDGAIFTLYDEIKNEGLKENSSVRPDMDTYMLLFRACERSALYNRTFVFYQQLREQFRLVPETAVYNTLLGYCAAVRDVAQATFLVEEMKQLNVPRDVNTYNCLMSVMVESAPYAETLKVFQELLSLNLRPSNRSYNTILKAASRHSDYDRAFQLVEEMKKKGLIPDMETYNYLISVCEQRIDYVRGTSVYSAKRSTREQILQGSHAIAELVMTLLREMRSMQVCPDTYTYNKALSILLRCEDERVFVVYNDMVRHANEIVDHSSSVGRATSGPSRGLGIARGSVNEPNRTDAGTLLEDALQAEDEEEVGNIRSTAVRPNRETWRQMIKACSFYHHFTLAKEVSADMRRSGVTLSASLGLLLLEVCCAARDVRWAEDLLAELKVRGVLIDTPLMNAFLSVLCAADAGEVVFTEYEQMRMGIHPTSAWADTDTCNIVLRYAYTKPCKATFAENLCTMMAQPYSTTAANEETFCIRLEALTDKMNVPMESVIAYVEDVVHNCDALTTAFYHSVLQFFLVRDDARIQAWFDRLSTEHGNASSASASAADVQCYTTLMQYYLSHAQYDMVKQLFHKIQCSSALEANAECYHVLCEVARRQGDVAAVKRAFDQARVSCVVLDVHCYNSILKTLVEHTDAFVYDVLSDMQKNRVSPAESTMAVFIADAHGRQVLAEVMSRALFYTPPPPIVLEKMRALGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYD8</accession>
    <name>A0A088RYD8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_300750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701110.1">
        <property type="nucleotide sequence ID" value="XM_010702808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYD8"/>
    <dbReference type="GeneID" id="22577129"/>
    <dbReference type="KEGG" id="lpan:LPMP_300750"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300012900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_300750"/>
    <dbReference type="eggNOG" id="ENOG502S0Z7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275836at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO00310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="204" mass="23270" checksum="926D509F746D93F5" modified="2014-11-26" version="1">METWQEFLRELQRVELGWSLAPNAGGTLQLKIHDHLEPGDGVLCELKGGTNRSAPLAEFFEACGSMSQGTISRVEIQFFDEESCSVLLIESKKRLGDTPFKDEPPILPFFCQFNCRGTSVSLSVLDKKTLIRTPLFSDISIQTLNYAFMTSLPLFLKREDLGIRNVDFVTKDQMRHFRYAWCFLRKESWMTPVELGELDALLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZ32</accession>
    <name>A0A088RZ32_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="5">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_323670</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="5">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="5"/>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702049.1">
        <property type="nucleotide sequence ID" value="XM_010703747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZ32"/>
    <dbReference type="GeneID" id="22578108"/>
    <dbReference type="KEGG" id="lpan:LPMP_323670"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320043600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_323670"/>
    <dbReference type="eggNOG" id="ENOG502RR07">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10256233at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="134"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="508"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO01249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="684" mass="76370" checksum="463F082872105B6C" modified="2014-11-26" version="1">MLRKRPMLRWRPEKRLPLRFRSVPEEFTDLRTADSRPILFTPKRPAPLRDVTRLSDVLLDGTAVSTCSSEDIAQKPVAVVDPERMGLPTQLVRYLEHHFLDTNHSLSTAAAVPTSLPSSSTSFQGLTVAQARILQHLYAKQDVAVCAPTGTGKTFALCLGVIARLMRDGPMRLLSTIILVSNDYLCWQVERWLQEMWWYPNDDRLAFAATGNLTEEHVYRRLTKELVRDENETARILGTIDNRPYIVVTTPDVLWRFYKRRRAAIQKREQRKNNKGYSFSLMPVLSTVDLIVVDEVDEVMPSTRPSAAGNLLLRELFRYTKYQAPVQVVLTSATLAGSTVNHIRRYMKKNLLADRTARVFEEARESATRLAAVSRTVSRAAVPHGIRNLFYTADTQQEQRLCLAKVLATTCPSLHPLASSEGDAEDGESSHATCAATAEHQDYILLILPDCANVEDFINCVLLPGQADALQILGSQGDARCADYLVERLDYTMEVQQQRRRRAETHKFIQRTVRKVEALDGDVDYCSSAPQSASLFRRLEREASATAPMHAVASASQAPAQKPSALSPAECAADSLAASSSPLRSSRRCFITCHCSNVRGLDLPHLTHVVILAQPTTALEYAHWCGRVGRFGRAGVSVTLMARSATRHMHQFCDSLGIAFHVERRHAEVDVNAERWLCGADAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZX5</accession>
    <name>A0A088RZX5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_340290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702458.1">
        <property type="nucleotide sequence ID" value="XM_010704156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZX5"/>
    <dbReference type="GeneID" id="22578533"/>
    <dbReference type="KEGG" id="lpan:LPMP_340290"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340008000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_340290"/>
    <dbReference type="eggNOG" id="ENOG502S036">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24183">
        <property type="entry name" value="FIBRONECTIN TYPE 3 AND ANKYRIN REPEAT DOMAINS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24183:SF1">
        <property type="entry name" value="FIBRONECTIN TYPE 3 AND ANKYRIN REPEAT DOMAINS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="216"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="249"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="316"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="394"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="329"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="341"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="401"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="427" mass="46398" checksum="C2B17E5AD5440DDC" modified="2014-11-26" version="1">MQRKYTNAQALAVYQALQQSGGLSVLEDDTATALYLSQNAAATGELNFTPGLLERLTKRLDKGGMVLDPFCSYDYADRRHIRNFSMSIPIPFSAFDGIRRSKHQVQLTTAQEENVLKSFSKLLNGEDTKKNGATPPAKGAREISVALPFVSAFFDQRCPELHNSVLTGSREGATYLLLSIITGHKELCAKCLKAGANPNNMSFLRDESPAPGDMFHGYSPVFMAVLAEQVDILELLCSSGGSIHVYDRWGRTPLHAAMALESTETVQWLLAKGAPLYVPDGFGILPADSCVGTQYAEYSMPMLALQESPKCPPPSYFNETAKSWATPEPENKSNAEKGSTKDAAATSSDGSAAEGEARMEPCRCHSGRPVGFCGCIDDMLVRWARDRLSTEWSPGVNFSELAKKQAAAEEERKRPTYGAGSNRGGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0B4</accession>
    <name>A0A088S0B4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calpain catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_321030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO00990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701790.1">
        <property type="nucleotide sequence ID" value="XM_010703488.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22577844"/>
    <dbReference type="KEGG" id="lpan:LPMP_321030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320015400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_321030"/>
    <dbReference type="eggNOG" id="KOG0045">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9374162at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053033">
        <property type="entry name" value="Androglobin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46298">
        <property type="entry name" value="ANDROGLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46298:SF1">
        <property type="entry name" value="ANDROGLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="3">
        <location>
            <begin position="301"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="456"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="721"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1008"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1140"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1410"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1715"/>
            <end position="1777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="486"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1008"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1429"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1719"/>
            <end position="1735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1757"/>
            <end position="1774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO00990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1890" mass="200304" checksum="72C63A11B45414D7" modified="2014-11-26" version="1">MPAKASSAPPRAALAGVCSTFVDGRFCSLPLWDDAQVAQEKWGDPLTVSVPSVGGDGGREAKEGGGRSKAFSGSKQGSTSFGAETHFEDEATHHAVEAFIVSLCPPRQSDRDAERVCDVSSSDEVTWLRPTEVFRPFRPVVHHNVTPFMNPYATAEALVPVAAKTEEVQCQSPSSAGAVAPNNNTSHRRGGGSARQSSAAAPVQQAFYQLYPEAITVLDTFLQEERELWTHCTPAESVRRYRALPPLMQPYDGVLIAGCAETPAQACESRYSTALRHKLQQAEQLASLAETPPFLMSAFNSALMAVEQAQRYIPAGWYLWELVYPHAPGTCHPVYNPFGKYAVKLFVDGAYRKVLVDDCLPVDVLGRPLLSITSRKELWPCLIAKAVVKALGPVSGVQALTSAPELIVAALLGNWVPQYLSPRHDIVYTTALLLLYQRQLTQLESLTEPFVKDTVASTEGRGRGDSAGDVTAKGGKDNARGRRGSPNPTLQKRISSSGARTSSVKRQQSSRACGVSGDAGEEAGELKPLTATEYCEPIIDEPLPEQPFYVCGLHAPSAETLKSKTASTASGGYGFGTQLYTIHAMKSFRNTVALLLHTTPRVCISEGIFEKEKDADDVSALHDWGRRAVRVGGTHAASTGKPSHGPEGVATPYIVGAQGDGTPSITDMMIMDSDRAASVTSCWLTLEEFMLHMETVIIWRQLIGRYANAVSVSGERLLQHQGNGSATGGAGSSDSPLSTALRKKSPTPRRGEVSPTATVTSSIAPQSSTPPPPSMMWWKLTAEKAVEAVVVVSCSAVMEAAARGTVAAKVPPTTLSSSHLWLSTGPSDPVAGLRGSAGAAEGHLERRVHFHHFQWDRAEPLNHIGSLTYTNGVLRSTVLHFRPGVHLLRVDLHQVQATDTISFLSDASMEVQLDLSHDANRDGFACLTDAGVYSAVQSCDVENVWLKRVFSFNVPTCVTLQLSTLDSTEDVMGHRQIYTTANQASAAIAAGKGGGNHGKTAASVRGAPQGGNAGAGVGRSGSTPPVPGFTAADGKKRSEGLLTADAENRAAFIVATRDASPSILRYTSLLLLNLDRPEDYCVGTAGRLVKLKLEPNEKGYLIIAYTKVPGSLMQSVQPQDKVAGEVGGMGSLLPMLTPTASPAEEELRTPESPLPRNSLPTPASTTPPLLFPAAQWKLTLRSSAELQSFDAVAHDLNNVTVEADLPRGGSPILCRRILTITEATHVSIVAQLRSPFPMPYTVRIVRFLTPAAGVPTSTTPKAIRASCSNNAPVGMSEPVAADLSRVAGTAPSQASAFVVYESPLTLHRLFVADVLLSTAVDTSVGKGGKGPVVSGSVGGAAAVYAIEAAVSEEDAAAWNESCRQSQEDAFLLYRKAAEEQAAISNERDLAEYHSNPDAFVRRKREAAAQRRQCATEAAEKAVSRSATTGRRRSGSMRRQSHHMPGVLESFAKNAHRGHSSSMRPDTAHEASVQHYLDTVDPNWAMHINIHLSFSSSRAEPKVDTPAPDALAELRRHMKETVSWLQEWSEPGASSVEAVAAASVMSPIATATPSGSRLGASRGQRDVAAATVTTVEDALRAEAARQSRLEYLGNPQHLFAVFLDPGDNADAAGTPAGVSAASFAHKSKHDTCVNSNGTGAAHSAVSSGTQGARCYRKEWTEANAGASSSVSDYPSSAHSPPVLMYDGPATQFRYAAPLQPAQYRIELLPLRSWEESPRAVSQGQDGVAGSGAAAAATSNRGRRPKASSSAPPAPAPPARAHGSGSGVTSGSSPRSFPDVTSGGFSTSIASALSCPLTAAECEAMLLPLRRPLTEASGSWDLALAPARVAKSENQARLKGSFHAYFEAMAEQKAANGDASGVALPLVYHSLLGGKEEDLGASFKLRRSIAFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0C0</accession>
    <name>A0A088S0C0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_340400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702469.1">
        <property type="nucleotide sequence ID" value="XM_010704167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0C0"/>
    <dbReference type="GeneID" id="22578544"/>
    <dbReference type="KEGG" id="lpan:LPMP_340400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340009200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_340400"/>
    <dbReference type="eggNOG" id="ENOG502SMBU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271065at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="2">
        <location>
            <begin position="197"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="629" mass="68820" checksum="6C4F3F48952F4195" modified="2014-11-26" version="1">MPSSRGVSLSISLTEAEVAPGGMLRGEVKVKVDASHKNGIVYEAIRLVFLAVERSCVWDDQGEFDALLNEYTSSRVYLDRHVTLAGFKTQTEDAETAAQVREEMLFLQHCATPYAAVAPAKPKMSAYRHYTRAEVLHSSIQMAAATTHTTGGAVVPDTSADNHNFVGSKEPILGDDGPQSTRAASGEGAAEVEFPVLMPGAHRFPFMLRLPPWLPPSFYYSFGGAKGHLKYSASATMLFPANGAGSWWFNMRNDMSGTTRDAEKAFNRATGAGAPSGEGARKRPGGGRSEEVDIDLDSVLVDERTNRRLTNIPSCSPSDLKISIDFDVLSVMPRRQLVAEYYQIDAHNLHQRPTNAPHESGDRARKSQRRSDKGSNCGGTKPTDMSTGVLEHHEDTHLALSALYQTFRCGWLRNMCCLQPQNALEAEVLVVGARTVLLADDIGASQALGVQPPMTPDYPQLGGPALHSPGIVPSPDLEAAAPNTPWPVSGITLRVRVRNHCPTQTVQCVRVELKVMVEIFKSLKTPHTFPGISYSSFDYTIPIPPGNQALFDVRLGLMPRFRRHEKDSELLLPPPGVRTANMTSNTFLQVSFPGMYTYIEEQEEAKGVVLMAETVDLNDEVLELPVRYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0Q8</accession>
    <name>A0A088S0Q8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L27A/L29, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_343630</name>
        <name evidence="6" type="ORF">LPMP_343650</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702786.1">
        <property type="nucleotide sequence ID" value="XM_010704484.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702788.1">
        <property type="nucleotide sequence ID" value="XM_010704486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0Q8"/>
    <dbReference type="GeneID" id="22578868"/>
    <dbReference type="GeneID" id="22578870"/>
    <dbReference type="KEGG" id="lpan:LPMP_343630"/>
    <dbReference type="KEGG" id="lpan:LPMP_343650"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340044000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_343630"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_343650"/>
    <dbReference type="eggNOG" id="KOG1742">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="255847at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000015">
        <property type="entry name" value="60S ribosomal protein L27A/L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="4">
        <location>
            <begin position="72"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO01986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO01988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="145" mass="16139" checksum="0E160A312361CE78" modified="2014-11-26" version="1">MPTRFKKCRHQRGSTFCGYGRVGKHRKHESGRGNAGGMHHHRINFDKYHPGYFGKLGMDHYHRKKNVTWKPTINLNNLTRLIAAEEAAKAKKGGVLPVVDLQSSGYAKLLGNGHIQVPCIVKARYVSKLADKKIRKAGGAVVLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0U3</accession>
    <name>A0A088S0U3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Galactokinase-like protein</fullName>
            <ecNumber evidence="7">2.7.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_342580</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.6" evidence="7"/>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702684.1">
        <property type="nucleotide sequence ID" value="XM_010704382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0U3"/>
    <dbReference type="GeneID" id="22578763"/>
    <dbReference type="KEGG" id="lpan:LPMP_342580"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340031900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_342580"/>
    <dbReference type="eggNOG" id="KOG0631">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275179at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019741">
        <property type="entry name" value="Galactokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF7">
        <property type="entry name" value="GALACTOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457">
        <property type="entry name" value="MEVALONATE KINASE/GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Galactokinase N-terminal" evidence="6">
        <location>
            <begin position="22"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="4">
        <location>
            <begin position="125"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="5">
        <location>
            <begin position="363"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO01884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="476" mass="53271" checksum="7A268732496E07EA" modified="2014-11-26" version="1">MPAESYSDERLDSTLQTLAPIFREEFKVENDADVEWLLFTFSPGRVNLIGEHVDYMEGWTCPAAVLEGTHILVGRVKHFEKHPKPKLRFYATYTKEHFNMDRLGGGKHNKAWTTFVRGAVTLRLNRLGVAINDPSLSGVCMVVHGTLAMGAGMSASAAFGVALIHAINSVVTKNYQGCPTSNGRRYSILPTMPKQELVELAKEARLIETEYCGVNVGIMDQFISALAEVDKFMFLDCKDLTFETIDMTPLLGDGEYSWMLIDSMVKHDLLGGTAQMYNAVRNDLENSQKKIGEHRYRGKPYSFSMMVRNPDQYGFDGDVEKFMSEFKPLMTPGEFERGTYQIMEQLRTLEFRKVNDATLPLSREERVKKAGAILNAGHAGMRDFLKVTTPELDYLQELINEDKDVAGGRMMGGGFGGCIILLLRSGTEDRVLAHVREKFKARFNVENTCYRMKRAGSGGFVVSLEGKNQNAAGSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1P1</accession>
    <name>A0A088S1P1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_040820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="AIN95406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703728.1">
        <property type="nucleotide sequence ID" value="XM_010705426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1P1"/>
    <dbReference type="GeneID" id="22572041"/>
    <dbReference type="KEGG" id="lpan:LPMP_040820"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040014400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_040820"/>
    <dbReference type="eggNOG" id="ENOG502SMJI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267401at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="630"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="684"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="791"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="880"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="938"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="987"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1168"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="397"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="645"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="699"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="765"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="791"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="896"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="938"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1018"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1174"/>
            <end position="1184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1211" mass="127958" checksum="DF6DB9BB7C707916" modified="2014-11-26" version="1">MTADRVRCGSASHALNGIGLPASNTVTPPSPPRQGSFAVVSTLPRLASSSQQPMWLTNANRDGELSNEMLLGSLAGYMPASAVTYANSAAAAQRSISATAAAPYLSASPAAALHRSGGHDHSADHPLETLSQSVLEGSRSLSEDDVPQARHSSGRGSGTPSLALPQQRPSLDAGVQGGGVINSPDLPGTRQSITVLKVTRDGRPQEWAQRRSCDSTAHAGNGWSTLGMHMAPAQPPRKASFNQVDTATPRGSASARVLLESIASIGETFTTVDAADTAVPQALTAAELRQRPSQPQQQQQRRPLPRPPRHSSASVSTVLVQQPPSIAAITAPQHIRPQNRASPRAPVSAAAKSAQAAPFSMSPSTTSSLVAPTPHNDSRSSRQSSCGAPRSSHGPELSATALTTTNSSATPRHGPSCNGAVREAGEPLPIGPATLQVSTATLTKTTKKVRYLLPDEPFDPDAPDPSDAGGLTAEEEAALLDPVNYTCAADEVASRYPMLLRRSSAQGGDLLHGRPEPAGKRLENGAPRPTFLLDDGNRWSRATNRPTVATTRDPSGTMTTQLPAPRILQKTSVANNSTAPNTNSEPFPAHQRVAAGGSMVQACNGKEAGGYLLQRHVQQVATGNQLVKGTVFQPPSTGKRHTMRRCREHDENRPSARVLPPQPQHRRRGTMEGLYDEILKRTQQNRRTALPTTIPPTAAPLRVLALPPPEAATRAAPPTTERRRRPPHLSSAEPRPLRRGPGVNPGAAPPSRSSSQPYMPIACYSSETPSGSEMSSRNEYRTPLLDSAPQLQQPVSTPLNETGAAATGSPGPRLPTSAPHPHPGAPQRQQFPSSSVIADYGAAAVLSSGSSTPGYTSGRFSKYNGAAFAPPAASEVMHFCSSGSGKPHHSILGSDAPPPPPPAQAPPSRVSTACTSPAGVTPLPLANYENPRAQHCQRQLSSAYSDNSDVQYEEDEEGYRAAPVDAYDSDTADKADTTTDMLTLHRHGSFNHNEATPAPSVRMSASDTNGAVTEARRSQLQQYNRTTSAQEAPQTSNDTGSSLPCQGPAQPHAEESPSKCTAAAHTGNLPTEEMRQPHYEARPHYRMQGSATPPPNPSPVTFAAASFSTASAPASVTSEAEYYEAPESASSCGTVTQPIAVSERSEDEMIDSEDDCLVKKGPLVLVFGDEESAPEGHTDVREWDGCEEYEEQSEYREGSNQEPEEQSWTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1Y3</accession>
    <name>A0A088S1Y3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">CRK3</name>
        <name evidence="16" type="ORF">LPMP_350570</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Probably involved in the control of the cell cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702996.1">
        <property type="nucleotide sequence ID" value="XM_010704694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1Y3"/>
    <dbReference type="SMR" id="A0A088S1Y3"/>
    <dbReference type="GeneID" id="22579086"/>
    <dbReference type="KEGG" id="lpan:LPMP_350570"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350010800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_350570"/>
    <dbReference type="eggNOG" id="KOG0594">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07829">
        <property type="entry name" value="STKc_CDK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000574">
        <property type="entry name" value="Cell division related protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000375">
        <property type="entry name" value="Cell division related protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF254">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="16" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="23"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00059987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00064639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AIO02196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="311" mass="35611" checksum="A3AD9581E3ED0F4C" modified="2014-11-26" version="1">MSSFGRVTTRGGDSGTRDSLDRYNRLDVLGEGTYGVVYRAVDKITGQYVALKKVRLDRTEEGIPQTALREVSILQEFDHPNIVNLLDVICSDGKLYLVFEYVEADLKKALEKQEGGYSGMDLKRLIYQLLDGLYFCHRHRIIHRDLKPANILLTSANILKLADFGLARAFQVPMHTYTHEVVTLWYRAPEILLGEKHYTPAVDIWSVGCIFAELARRKVLFRGDSEIGQLFEIFQVLGTPADAEGSWPGVSRLPDYRDVFPKWTAKRLGQVLPELHQDAIDLLSKMLKYDPRERISAKEALQHPWFSDLRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S205</accession>
    <name>A0A088S205_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gem-associated protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_351310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703069.1">
        <property type="nucleotide sequence ID" value="XM_010704767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S205"/>
    <dbReference type="GeneID" id="22579160"/>
    <dbReference type="KEGG" id="lpan:LPMP_351310"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350018700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_351310"/>
    <dbReference type="eggNOG" id="ENOG502S06J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277659at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12794:SF0">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12794">
        <property type="entry name" value="GEMIN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="60173" checksum="8C115D76C21AC40E" modified="2014-11-26" version="1">MADAAAYLKLGKKIQCNRFGRAGVARVEATVIKGDGYATTAGNRGTAGVDATSSSSTSGLVVVQVNDAQREIQQLPMKRKRVAKRSRCDSDEEDPLAAPLAMSSVTVTDAPVTNICEPLSDVLATRDVTLDDGLNLANVASPTAPVPPVEGVAQRTNLMAKWFPAFLQERKLDAAVAPSMMFVEATVERVNKMREYVLILRYGIEDVESLLEETRQAQSIVWNKESTDCTSTHQRQRRECWDLTGKDVRALVRSVGLPRFTQALAEFSDVVFNSRLSAAAAVYSILSRRRRVGTPMDYNIKAWHEYLNTHGPQRGYAPRLSDLLWLSAASTSAMFTATASRLLRGARSCTKPTSVSDAAEDDRASYAESENDSRSSDRPRFFDNTENAAEEEEPVTTRIGWLSASVTFPPTLSPDQRALLSFLRFLMPTSHTSLERTSSAGYGVWLFAAFSALDIPLDPDTDRLAHDLFRTCCRHLRTLADWQGVSGSTRDLLLRKLHPRTQATAPPLYASLDDICREDVLALYTIVVVLARFFRQNQDHFIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S210</accession>
    <name>A0A088S210_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphatidylinositol 3-/4-kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_353010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703238.1">
        <property type="nucleotide sequence ID" value="XM_010704936.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22579330"/>
    <dbReference type="KEGG" id="lpan:LPMP_353010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350037600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_353010"/>
    <dbReference type="eggNOG" id="KOG0890">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="431717at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012582">
        <property type="entry name" value="DNAPKcs_CC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF1">
        <property type="entry name" value="TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01344">
        <property type="entry name" value="NUC194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="2">
        <location>
            <begin position="3812"/>
            <end position="4148"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="3">
        <location>
            <begin position="4161"/>
            <end position="4193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2695"/>
            <end position="2714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2736"/>
            <end position="2758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO02438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="4193" mass="458341" checksum="DFFE2AF894DAA784" modified="2014-11-26" version="1">[encoded data, 4193 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S232</accession>
    <name>A0A088S232_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_353210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AIO02458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="GeneID" id="22579350"/>
    <dbReference type="KEGG" id="lpan:LPMP_353210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350039800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_353210"/>
    <dbReference type="eggNOG" id="ENOG502SBDX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270445at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO02458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="249" mass="27302" checksum="1035C14B8C0C4441" modified="2014-11-26" version="1">MASVDTQWAIKSLLQLSHHHLRHSAATAFSSPSCLVLPASTSFGSAAKAVQVTAMPRLMRRSCNPSHVILLAKRPSGIAGVTLRQGNRVSWTGLPAAESSPAPAPCSRKTRLLASYLQRRGFAMIPPVATEARSSSPQFRSVERPMPLLLHTNHLIGWKLNDASPAFPVYAHTIAELQRLRSSDVAALRPQHCLIANEYCEWDNWREVLGEPGWDLFSADDATVERLLQDGLPVSTLEREAGLYPVEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3G8</accession>
    <name>A0A088S3G8_LEIPA</name>
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        <recommendedName>
            <fullName evidence="3">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_355700</name>
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    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
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            <taxon>Leishmania</taxon>
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    </organism>
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        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
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            <authorList>
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                <person name="Restrepo C.M."/>
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                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
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            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="lpan:LPMP_355700"/>
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    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_355700"/>
    <dbReference type="eggNOG" id="ENOG502S1T0">
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    </dbReference>
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        <property type="component" value="Chromosome 35"/>
    </dbReference>
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        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
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        <location>
            <begin position="32"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="3">
        <location>
            <begin position="38"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO02701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="241" mass="27602" checksum="3225E0460EC135AB" modified="2014-11-26" version="1">MLASSAMMTALRVLALVVLCLLCGLCTRVDGSKSLHAGVYVKLLPGKEFCADYHVYRDPQSDPVLVTFQHRCIDPRLAGIITKLYAPSREPLKRGLQIPLSENIDTFGDISQIFFHAEQTGTYKMCFLLPLKKPAMRFEMSFSAVNDIVEPPKLEDDAFVVDKPPEMEDYADRLRMLNLSVETTVDELRMYETRRYFFDETVNSAFYLCIFSVLLNIVIAVGLTVWSERYLERYFVRQKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3J1</accession>
    <name>A0A088S3J1_LEIPA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_091420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AIN96056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3J1"/>
    <dbReference type="GeneID" id="22572712"/>
    <dbReference type="KEGG" id="lpan:LPMP_091420"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090019700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_091420"/>
    <dbReference type="eggNOG" id="ENOG502S9AG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273179at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="139" mass="16262" checksum="3E42887A38220826" modified="2014-11-26" version="1">MPVDYSKKLDALRELYERVQQKDANIAEEAYAAAGVKNKARLKDIEKEISATKKKVSHEVKKVTDEEIEKEYEAMAKEHKMTIEEFKETVLGKERQPGVGSEFSERHTALRRERAEQRDLKEMRRQVERGDFDMAVDYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S459</accession>
    <name>A0A088S459_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tubulin-tyrsoine ligase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_110400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696889.1">
        <property type="nucleotide sequence ID" value="XM_010698587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S459"/>
    <dbReference type="GeneID" id="22572905"/>
    <dbReference type="KEGG" id="lpan:LPMP_110400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_110006400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_110400"/>
    <dbReference type="eggNOG" id="KOG2158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070740">
        <property type="term" value="F:tubulin-glutamic acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241:SF157">
        <property type="entry name" value="LIGASE-LIKE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="506"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="607"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="717"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="990"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="609"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="663"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="730"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="777"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="901"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="998"/>
            <end position="1009"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN96236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1009" mass="111075" checksum="8173B0BBCECA4ADA" modified="2014-11-26" version="1">MAATTPTAATTPTAATTPTAATTPTAATTPMAATTPTAATTPTAATTPMAATTPTSANAKSPVTSAGQHKGVIMTAEMQRDSKRIVISRPSTNLRIVHMTDLARPSIAYKLTPHLTRQPTALIRRIRHPRKSLNVFLTKYPLIRKIAEEMGFEMETTEEELNEYKFNLCWSDTVLSLMRLVRLRNWQRTNHFPSMHLLCRKGHLGTTLGKLRRKLPSHFAYYPRTWSMRSERMQFTRYMMAVRQRRIFKYFILKPNSGCQGRGIIVARDPLTALEEHTLDNYIVQEYVHRPLLLEGKKFDLRVYVLLTSIRNPSVFLFNDGLVRICTEPYEIPNEENAKQACKHLTNYAVNKKSSDFVFNTNVEHMDVGNKRNFGFLNRWLAESGHSPDIFWHEVGFIIVKTILAAQPIIAKVYDSCFPTGFNEGYCCFEVLGFDILIDNKIKPWLMEVNHTPSFATETPLDLDIKSKLISEVWSIIDCKPSDYERDRQREHDEFAKRNMPPWASNHPVYGCQLRKNTSRGPGVDDSDSPLDHSSAPADRTHAEEEIPSYVHARRRLEDSKLKNFKRIYPSPNSDVQLVYDTIQNLAKLESANSRLYYNSTVAAPVPPSTLTSSPSPSAHTNSILVSRGRPPSLGPLLTSRIGGSSGTPRIALPQRTQTPLMGPNTAAAAQTPGAVANNVPTFTTPSVTPTLPPGPEGQASYTTPFKLIEKDILRHRRRSSDVRGGAPALSNTSTAHSSPTPSENGATVISTPAATKPPKSPRVHTPRISSVHARKSLSSETLPSTPQQDSAKKAAADSAVANGVKPHAAEVQRRVTKRSVTVRASKATTINVSPADATAIPASVAPHKTVPKTDKPSATAADASNGLPTFHQNGDGAAAAAPGTIAPYLAVDRPIRISSRPAQGQKLSSPSPVTTPKGPERPRSNSHELPFPRRKSASLSSSMRDLDLGGLVHSRQRSQDRDMHSMFTHLEPTEEELARLATLQAMLDYEAAADPKPDDDDDDYNLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S4Y8</accession>
    <name>A0A088S4Y8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Aminopeptidase P1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_355690</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703500.1">
        <property type="nucleotide sequence ID" value="XM_010705198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S4Y8"/>
    <dbReference type="GeneID" id="22579597"/>
    <dbReference type="KEGG" id="lpan:LPMP_355690"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350065500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_355690"/>
    <dbReference type="eggNOG" id="KOG2414">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4215474at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF4">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="8">
        <location>
            <begin position="41"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="7">
        <location>
            <begin position="408"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="340"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="605"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="340"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIO02700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="828" mass="89875" checksum="CE19FB409F527C7C" modified="2014-11-26" version="1">MLCRAWRTASVHRRSVLSTWNSTRWIQSLNAVREEVSVQEYADRRKRFLECLPDNSVVLLPAADESLYSHDILWPHRQDSLWYHLFGMRTSMRRQLAPPCSAITEDVRITMAAFAKGMQGIPMRTLLCVPPVTTDSATLVWGSEAAPLSEYKRLLGADEDAAPSPRTHENVVTTNEVGTVCEEVRRFITEMAQQQIMQWLVHSDHPLTTSPGGGGGGGGGGGGELGGRLLPLGLIPSVFAAYPQQLRWDGRGYRLRQRSKSLPHTKTRGAARSTSVFHHPLEAFFFTLSATPFVLHLPRSLLCAAAAAAAAAPGQQPVCSVVKFSYSAVDGYTPGLAPSTASVLPTQGSVSSTPRGRDPPASLVTSSVSADSESDNTMQMHLPVLRSDAYAWLYRQAKPPSQLRQHLRSARATEDAFLQLMRRATTTLSEHVLHCAFQRAVCDISERAGAAVQVRSAYIPVVASGVRGTEIHFTDNDGVAALGDVVRVDAGVEVDGVPTDCTRTLPIGCSHFSPSYVPLYEGLLQIQRKLLRCMGPGVSISEITRMHIAETQALLCSLGVDVRRTATSSQEQQVPLNLVRSCFCAHLFGHFFGLDIHEELSSASQPHARVAEKEGSARQQRPTSRALQGGMMHTVEPGVYIPSVQRASLFGLEGAHFPIAFHGGVGMQIEDDVLVLPSPGDEDVDVCSDEESRVYLPWSRGEYLQHALAAFHRYYDGGDAGTTPSLLVSVCDAHVSTVGAGGMTAAARNVLRFLFAQRVSMDGLPKAMASLAADVCAIQQQTFVPNPAYLDGPPVPHAAVSDWYPYSSIVLTATIPKDIELIEVVMQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S714</accession>
    <name>A0A088S714_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peroxin 13, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">PEX13</name>
        <name evidence="5" type="ORF">LPMP_190040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697999.1">
        <property type="nucleotide sequence ID" value="XM_010699697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S714"/>
    <dbReference type="GeneID" id="22574058"/>
    <dbReference type="KEGG" id="lpan:LPMP_190040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190008700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_190040"/>
    <dbReference type="eggNOG" id="ENOG502S2KK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="191061at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="344"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="69"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="120"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN97346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="417" mass="45348" checksum="7F12BF8250E377A9" modified="2014-11-26" version="1">MFGGIHGGSMYGGGLGIGSSMYGAGLGSMGGMYGGGMYGNSGLMGGSAHGMSGVLNSYARNNQYGSSSIYSLGNNGDGTQNNGMQSSLSLQQQQQTERFNPLISPINQHSAPLPPLNESPEERSRRIQAEHKKERQLIRQQRDQHRQARLQARMEIAGHLTNVLVQGLRSAMELFGVCFGTYYSIRAVRAFSNSQERIPGMGMYMGANYPCGAAVAKTQAAATSALGAQQIATAPSGGPRKWRTWLLCIAFFILGEVVYGIATRQRTKPLQHRRRIARSAKSVYGGVISQDEYEVSIHSSDTESRLTEEDRGEAEMLSEAWGQACNSDSVYRTSQAVRPSGSNGARRVYYALYDYQAQQTDGPCLSFKAGDEFVVEDYAEGSWCEAMAVESGNYSSHGRRGLVPSNFLRLAERITKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S8N1</accession>
    <name>A0A088S8N1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_204830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698683.1">
        <property type="nucleotide sequence ID" value="XM_010700381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S8N1"/>
    <dbReference type="GeneID" id="22574695"/>
    <dbReference type="KEGG" id="lpan:LPMP_204830"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200055100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_204830"/>
    <dbReference type="eggNOG" id="ENOG502S6NJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273789at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="520"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="606" mass="63151" checksum="5D86F0DF9911C824" modified="2014-11-26" version="1">MLTTFLHVVLIVAGLIGLLGIKQRRIRHIPTRRTHITRRNAEGTLWLQRFVNAVLDMLHSALAEQQASESAEAAAARGGASDCYPLTGQVPGAPVENDTSAKFAASAGSDGTVRQDDADSVSSAEVLSELPFLNALKVQLEEQISALLEDKGIASFADFRVKDWGGKPPVIKAVYLSHGGGGSGGSGSSATSTTGASASSFASPATPLPRGLGSMTSMDNIVAGGVASVAQQRAAAGLPLGNTSGLGQQAHKQLQKQHSQMLSPVSGGSFAYSSPEQQNDVSGDALNAAGCSAMSPSMLSSLRYRSSGEEAGVTAVAGAAARERSLPGVMAHSAPLGRSGDVHGGADTNLPAAGPSSVVTAAGVTTARTSRARHTTGTTRSLSVLDAEVEVEYSGNFSVSLNTDLPIARGRYLQVYVSLSDVRMLAAHVRLRLSLEYEPATVESPQPQPYLSGRLWLLSDPMFDAAFHSTLTQYHIRDFFMVPMLVKFFLLRFVRTKLRPSSQMVTSSFSLGTHRRRAGAGVNDSGAAAGGAASGTGGKKNGSGSTGMLDDLKDDAQGGASEESGLSFRVQLPADVVDGGEQCWSSMARDSMSEQPVPFTSAYYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S9H9</accession>
    <name>A0A088S9H9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_212140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698998.1">
        <property type="nucleotide sequence ID" value="XM_010700696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S9H9"/>
    <dbReference type="GeneID" id="22575036"/>
    <dbReference type="KEGG" id="lpan:LPMP_212140"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210025100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_212140"/>
    <dbReference type="eggNOG" id="KOG0176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03753">
        <property type="entry name" value="proteasome_alpha_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000019">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033812">
        <property type="entry name" value="Proteasome_alpha_type_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="6">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN98291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="244" mass="26794" checksum="56EAE6471096C7F8" modified="2014-11-26" version="1">MFTSKSEYDRGVNTFSPEGRIFQIEYAVEAIKLGSTSLGIRTPEGVVLAAEKRVPSNLVISSSMSKIMEIDSHIAAVMSGMVADARILVEHARVESQNHRFTYNEPMHVESCTLATCDLSIQFGESGGKRKLMSRPFGVSLLIAGVDEKGPQLWQTDPSGTYTRYDAQAIGGGAEAAQSVFTELYHRNMTLEEGETLAVDILRQVMEEHLSPENIEVAVVRADDGKVHMYAPAEIKAIMSRLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SAV7</accession>
    <name>A0A088SAV7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_241440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699483.1">
        <property type="nucleotide sequence ID" value="XM_010701181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SAV7"/>
    <dbReference type="GeneID" id="22575553"/>
    <dbReference type="KEGG" id="lpan:LPMP_241440"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240019800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_241440"/>
    <dbReference type="eggNOG" id="ENOG502RYEV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273523at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="492"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="820" mass="88618" checksum="94547D73DF7A9129" modified="2014-11-26" version="1">MHLRWVCVTAVAMTSASLPHRSVADGLLALPRGPAARGLRQGRRAKERLSDLNPGTAPLRTPLRGARCSTWTLGRHVLQTDGAGAIEARGWMRSWGGIADAAASMSPLASAALCTRSPLACLRASCAALATPCRCCVSSTGVARAPPSPSHDFLRLRGSHSKRPPSDSLPPSASQYKKRVQQHKRRGQAPVHGNARSCRGQKSETLRLQTPHDCSRDDASPSKPEVASVNDHEDGASVDGDGTGESSAHGAAAPSARGHGATAGWGLEDVNSRTGRTQLEELYERNLDRIRVILEQPLPVMPQDGSIDPDLFVGFAFYSYQLRDQYRAVLARELQVPVKAVRLSIAWSGRFDVRRFGRVQKVCGVCLDRQALLAATHGETEKSPGSGLRRKEGDLAAQTPIVEVDEAASPLPETLQNRIHALVATINGRKREDLLRVSFFQASLPIPEVEFALTRREHRLLHRLHEWIRRHVLQRAVVVVVYGVPPPPPPTTATGTRSASATAGSWSDSSERKGGTCDTAGPTRGDAPQRDRYAPWQRLCSARTTAQKREVQEKWLRLFHRRKLVPSMISLTELATEVAVAVVRGEVLPIDFGHATREMAGAKQTSGEAEKGGGEHRASPDTPLMGVAPTPAVLSASLQDVVVRIAAASSSSAPPPTPGDYGALAEDSDGCTMVCRHTQDVIAPPRDADTATAAADVGPRFRPASTAQEEATMRWVRLVYQALFLREAQGSTDGSSCTDAEQPAMRVSHQASLPALFAQGAYAGGQEEVAYLQRNRVAMDALLLHPHEISFKKKFVSRMRNGHRRLRMEEESAPPYSASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SB28</accession>
    <name>A0A088SB28_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_242240</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699563.1">
        <property type="nucleotide sequence ID" value="XM_010701261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SB28"/>
    <dbReference type="GeneID" id="22575633"/>
    <dbReference type="KEGG" id="lpan:LPMP_242240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240029700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_242240"/>
    <dbReference type="eggNOG" id="ENOG502S4ZD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF458">
        <property type="entry name" value="PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="161"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN98856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="278" mass="31522" checksum="175EFCEA23587749" modified="2014-11-26" version="1">MMTWEEALTSWGAVYIALLLPAILMLVNFVFGKCFVSEAMCRARHTPQSVHTRSRILGRAYVALVTLSFAWQYYVVMFVVRTQTDGNADVRACNPLFCVWDLIDHLPYLRGMQLSLLVQCCSSDVTYLVLVGLFAFFYASCVFSVPQATPGSAAAEGQDVISYCRRCGTHIHQMDHHCYFIGNCVGERNRRLFLCCLVAGVANLSYLLYKYALWVFAHGDAVTNVGAILVVVFDVFLAGLLGFQVLVLRRGWTTREFLRRRRHEKEPVVRCILRLCFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SBA3</accession>
    <name>A0A088SBA3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_250780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699648.1">
        <property type="nucleotide sequence ID" value="XM_010701346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SBA3"/>
    <dbReference type="GeneID" id="22575726"/>
    <dbReference type="KEGG" id="lpan:LPMP_250780"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250013800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_250780"/>
    <dbReference type="eggNOG" id="ENOG502S8IC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264345at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="350" mass="37468" checksum="EEC6FC375FECA2FB" modified="2014-11-26" version="1">MDVVAGPSFVLRHIRRCGAEELNQTPQRTTASSTGTTTTSSSFYATEVLLKVGVPAPLASADSSPGKASPALVCYMCPAYILQVGCPALRELLADAFDGGPSEICGVGNEAGTNSAAAVALPSSSPFVVIPLPFLDGDVFHVLAIYLEYFYAFDCTVTTAITATVAHQSFTPLPSSSTRTPSSLRRPLNFQDLYALSTWEHYYVLCQLLGLERSQVDSLRLVEYGAWVDLLGGASAVRLPKGETQQKRQGAVAHDAALSQQRAECFSLANRRRMWSRLCQVLEVASRLGMSTLRLLCATVAANMLVDLDADGLARLMVSSGNGSGASGIPPFTAQARAQLLQRYPWLKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SBC5</accession>
    <name>A0A088SBC5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein transport protein Sec61 gamma subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_251040</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699673.1">
        <property type="nucleotide sequence ID" value="XM_010701371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SBC5"/>
    <dbReference type="GeneID" id="22575752"/>
    <dbReference type="KEGG" id="lpan:LPMP_251040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250016500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_251040"/>
    <dbReference type="eggNOG" id="KOG3498">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2401875at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.820">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023391">
        <property type="entry name" value="Prot_translocase_SecE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008158">
        <property type="entry name" value="Translocase_Sec61-g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00327">
        <property type="entry name" value="secE_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12309">
        <property type="entry name" value="SEC61 GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103456">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN98966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="69" mass="7804" checksum="D37F2A4483287AE6" modified="2014-11-26" version="1">MDFLDDILFHPIVAFTKNSRMLVRKCQKPNYNEFTTATMAAAIGFLMMGFLGFFVKLVFIPINNVILGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SC22</accession>
    <name>A0A088SC22_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_261180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699938.1">
        <property type="nucleotide sequence ID" value="XM_010701636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SC22"/>
    <dbReference type="GeneID" id="22576021"/>
    <dbReference type="KEGG" id="lpan:LPMP_261180"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260016700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_261180"/>
    <dbReference type="eggNOG" id="KOG0691">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000228">
        <property type="entry name" value="Chaperone protein DNAJ, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052423">
        <property type="entry name" value="EMIR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44094">
        <property type="entry name" value="DNAJ HEAT SHOCK N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44094:SF7">
        <property type="entry name" value="PROTEIN DNAJ, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="298"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="668" mass="73021" checksum="2934BB30E0EA6785" modified="2014-11-26" version="1">MLSTRLFCIVLLRETMSRLTMRRFVLQNIIAVAARCPSTTVASAVVAVMAGDTEPASTTAASSSSSAVSWLQRMLVKKHASSTSTSSSHFALVTAAEMEWIRRCRREDAEESRIVLATCPSRSMLRGIGGGVLNTVVGFVVSPLVFLAITLERMRLGSSVSALCTAPCYGLVWGGLFLACAQYAAVQQVTLSSYYSCVAAPLYYCVNRRPMAGVAASASISAPSARAWMWNGLSCCFEAPQGMPNARHPLLQLYDDPSVLRERAMKRASRRDKDKIKSNAKYSGKDKMSGVGGVADDDYYGLLGVPTDATQRQIKAAYNQKVLHIHPDRNPSPDAGQQFDRVTKAYRVLSNQQKRRKFDLGGAKGVDDTGSKKREAVRALFGGEEVHRVAGDVFISAFSQRVIDGLDYTSEELAVLRQRMYEQCRDELLKNYLVHYDAAATASETAAAGRKAADATKSSGNCGGPWKDGALATQLRKILSTGLAKEVLHTIGHEYKRAIAYHDMERTRLSSSGETGASNRGASPSLLSDVAAGCSKSVSLPNLMAARAQFYLKTVGPHRWQVQRQKFRHLSAVRSRTFKDSEAMVDLAWYTSVEELEATASTVALALLYDPKLPAAEAARRRDALEALADTFILYGQPYKGANQATMNQLMSSMRAYQQQQQREKDTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SCI3</accession>
    <name>A0A088SCI3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATPase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_270350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700123.1">
        <property type="nucleotide sequence ID" value="XM_010701821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SCI3"/>
    <dbReference type="GeneID" id="22576211"/>
    <dbReference type="KEGG" id="lpan:LPMP_270350"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270010000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_270350"/>
    <dbReference type="eggNOG" id="KOG0730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5421at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001025">
        <property type="entry name" value="ATPase family, AAA domain-containing 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF117">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="426"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN99416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="656" mass="71093" checksum="7DEBA1296617D28D" modified="2014-11-26" version="1">MIRVPGNWTCAHYPCAFAEIRNECYLCRLVPVFTAALTYELEASVRVSLIEARRFASQDFAPAETQHVVYTPCPSGIEYCPCSAGGLSSEPMVIRCPLFHYMAKEVTVDGPRRDTRATAAHVAAALMGRYVVVGAEFRIQDGVYTVRQVVLQKGYRGVALVCSDCRVRVNDSQRVGSSGLGRGGAVRPIGLDSEADQLLQLLLCADKSASTFVGVMARGPRGCGVSTTVRYALESVAATHTVLRWSSCFSPSEACREGRGGTVVLVITEAEHIFAAAEPELAKLHMRKLQRDAAVVRGGGSGAARSVVVLCVSHDYGLCAPDVLEELVTFYLVFSFPGASQRAVLLASVRGGSTMDWMGAAQRLVGRTCVETLEAARLPDIGSVLPFKAVRWSEIGGLAEVKDRLHRALVWPQQQPELFQRFHITPPRGILLYGPPGCAKTTLIKALCSEGNFSLIYLDSATVVSAYVGESERYLRDVFTRARRQAPCIVFFDEVEVLGGRRVSGGHDSEHVRLLSTLLTEIDGFSDICGVCFVGATNVPHLLDPALMRPGRFDYMVHVSLPTLADRESILQLLLCKTAADTRAIAEKTEGFSGADLKVFCSEALLALLKESAGVPQVFQEGAIVTAYLSQRASGFQGTHYDAAALDQFQREHASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SDA1</accession>
    <name>A0A088SDA1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="25">Dynein heavy chain, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">LPMP_280620</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700403.1">
        <property type="nucleotide sequence ID" value="XM_010702101.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22576507"/>
    <dbReference type="KEGG" id="lpan:LPMP_280620"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280011700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_280620"/>
    <dbReference type="eggNOG" id="KOG3595">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="447173at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000002">
        <property type="entry name" value="Dynein axonemal heavy chain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000013">
        <property type="entry name" value="Dynein Heavy Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002141">
        <property type="entry name" value="Dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000001">
        <property type="entry name" value="dynein heavy chain 2, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000009">
        <property type="entry name" value="Dynein heavy chain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000063">
        <property type="entry name" value="dynein heavy chain 6, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000001">
        <property type="entry name" value="dynein heavy chain 7, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.280:FF:000001">
        <property type="entry name" value="dynein heavy chain 7, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.130:FF:000045">
        <property type="entry name" value="Dynein heavy chain, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000020">
        <property type="entry name" value="Dynein heavy chain, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000005">
        <property type="entry name" value="Dynein heavy chain, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002429">
        <property type="entry name" value="Dynein heavy chain, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000362">
        <property type="entry name" value="Dynein, axonemal, heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001145">
        <property type="entry name" value="Putative dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041589">
        <property type="entry name" value="DNAH3_AAA_lid_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF68">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17857">
        <property type="entry name" value="AAA_lid_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
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    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="900"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain hydrolytic ATP-binding dynein motor region" evidence="17">
        <location>
            <begin position="1453"/>
            <end position="1779"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA 5 extension" evidence="21">
        <location>
            <begin position="1956"/>
            <end position="2090"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain 3 AAA+ lid" evidence="22">
        <location>
            <begin position="2349"/>
            <end position="2425"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA module D4" evidence="19">
        <location>
            <begin position="2491"/>
            <end position="2753"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain coiled coil stalk" evidence="18">
        <location>
            <begin position="2768"/>
            <end position="3123"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain ATP-binding dynein motor region" evidence="20">
        <location>
            <begin position="3150"/>
            <end position="3371"/>
        </location>
    </feature>
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        <location>
            <begin position="3634"/>
            <end position="3747"/>
        </location>
    </feature>
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        <location>
            <begin position="3779"/>
            <end position="3917"/>
        </location>
    </feature>
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        <location>
            <begin position="3923"/>
            <end position="4225"/>
        </location>
    </feature>
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        <location>
            <begin position="2100"/>
            <end position="2119"/>
        </location>
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        <location>
            <begin position="2759"/>
            <end position="2789"/>
        </location>
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            <begin position="3027"/>
            <end position="3054"/>
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            <begin position="3305"/>
            <end position="3364"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="Pfam" id="PF03028"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08393"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12774"/>
        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12781"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF17852"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF17857"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF18198"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF18199"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AIN99696.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="4230" mass="477055" checksum="521595AC3895DAB9" modified="2014-11-26" version="1">[encoded data, 4230 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SDN1</accession>
    <name>A0A088SDN1_LEIPA</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">LPMP_282280</name>
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    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
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            <taxon>Metakinetoplastina</taxon>
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            <taxon>Leishmaniinae</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <sequence length="855" mass="93493" checksum="BDCE267C9961A617" modified="2014-11-26" version="1">MLIRLVLLRALYTKQKSQSLTMQNWYEFGYNGFPSGEQRRRFYRQRDDPCDSEEERDYDDKTNDRPIFYYPLRESEDGVRSSSVSLLPSTSSGEDDKAGRRTGDEVPRMRLKGTYTSQRSRRARQAPHEDSSLRCLLHTTLYEDMPAWYGSSSVTLASSYSPHEMYTLQYGGAPCASPFAVSNQFSLWRWRLAPVPAASTPQNEAAGNIHCLRLIDDPSLRSCLQWSALHPALRLGHTSTLQAPPRIGHCVVPLASLDALVLQHFLSDHSHGAHATEASRLGTTAGRFGKKALDSIPVLLTGNNVDLYVSLVIGGASHLVDMSNSSGAGSRHSSSGIRGSMPEGDSNAFRGPNLGRVSIDGSHILSHPALCLTLIAHSVAQPRQHTIYFPLDGPSVSVLSSRAFATLTPWPDANSEELAHHSFAYIGGTENGRDPLSYLEVELFQLNLDTWVWSSNLISTYGVKPPPRFGHSVTMVKEDACLLMLGGVGAGRTYLNDLHVLDLKTRVWREVFIPFGVDLPRRAFFTAAILALPDTPLQGRSGGAHTAFDDADHTTFSQRAAAAVARQLTFASHLGQGTSPPPFLTQQGASSGDEGEGDDDIWPARVTGARSRGVLVVLGGECEGKPVTSAWACILRNGNWRRLSFPLRTQPHFSHVARSAVLAEADAERASRLLSRTDFRTALQALMERVVHPSSITTFDSLAYSDLAQEPYMAVCHGSLAQAVLLPSDTGVAQRLVLNGGSQGPPVSVMSEMSFMGTSLKDDVSLWLLTAQQQGSLASAFCKRVQHLHILFFNKNAGLSRAAQSILQSGEGKAAQPGSLSAENVRFNRFLSSCVLDGQLMEWTRLARKRLREEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SH33</accession>
    <name>A0A088SH33_LEIPA</name>
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        <submittedName>
            <fullName evidence="5">Small nuclear ribonucleoprotein component-like protein</fullName>
        </submittedName>
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    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AIO01117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_010703615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SH33"/>
    <dbReference type="GeneID" id="22577974"/>
    <dbReference type="KEGG" id="lpan:LPMP_322330"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320029200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_322330"/>
    <dbReference type="eggNOG" id="KOG0468">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:U5 snRNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Small nuclear ribonucleoprotein component-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Translation elongation factor 2"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044121">
        <property type="entry name" value="Snu114_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF6">
        <property type="entry name" value="116 KDA U5 SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="4">
        <location>
            <begin position="157"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO01117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1018" mass="110845" checksum="61B9B13162E5519E" modified="2014-11-26" version="1">MDFGYDEYGNRTSANGGGGEKGEEEGNADVRSVRESRDNSTCQLHGAEEDTLGRSLDNRDVENHSDFSDDVELVIGEEGTQRLDQPLIDQSEVQSHGRRGVGRNREVQFLVEDRHAEQTSTVSTSGVLLLNGDRCQQQPHDVSASQRYLDVLAALPDRMRNVVVVGSLHHGKTSLVELLLHENSYHKRQDEVDREMTLKSHALTIITGGAVLQPTSRQITVIDTPGHPDLIGETASGMRLADAVLFCVDVAESLSDHSERLLRHAVVNEQLPIVLVITKVDRLIIDLKLPPLDAYRKLRIVVDSVNNIIASCGTTYDAFLVSPERGTVCFSSAKLGLFFSLETFAMKYAALYPSINAAALATKLWGQVTYDKKEFKKILNFRQRPSFVQFVLEPLYKIVAHSVTGEAAQILSSDLAKLPRSPLSALQEAMRYFCGAPTGEILDAVLSVLPAPLTRSQWLSEKYGASALCSMTIEATASATEVERDAAATARANDLVIAVASLQRVFDDKDTLAAVVRVTHGTLRLNSSRKSKGAWVSSSRNGEQSRPRLIAFDEFSSEVDPYYEVEVDGLYLRTVEDGFVPVQQATAGQTVYVTGLPARSGSHVFLVGGAAAAAVLAEDEGAPCPSEARSMTSEWVAPIKVRSLGFPQPLLHVSMEVRDPTKASSVQGGLGVLLRTSPGLDVHKEETGEYTISGFGELQLDTALHELRHGLCPNAPVGISQPFVTLAETVQDAEGLLAMTGTRHNSVGFVSGVLPRAFTNAIEYEQLCLFSAELDEGHQPCRLWTVLRHDYGFDALDAQHILAAGPDCTKGPSILIDDTLPEETRHTLKVAHQRAIVSAFRATMAAGPLVGGMVRGVAAKLIFADIDASTRDAVVLSNARTALRHALFGARPRLMEPVMTAEILCTPECVLQLGDILQQRRGAVLGEEPIAATTLIRARALVPAMDSFGLETQIRMLTHGQAFPLFQFRQWDVVPGDPFDASIHVGPLEPARGHQLARDFVLKTRFRKGLPQNMLTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SI11</accession>
    <name>A0A088SI11_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_331750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702267.1">
        <property type="nucleotide sequence ID" value="XM_010703965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SI11"/>
    <dbReference type="GeneID" id="22578328"/>
    <dbReference type="KEGG" id="lpan:LPMP_331750"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330024400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_331750"/>
    <dbReference type="eggNOG" id="ENOG502SCRN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="258611at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO01467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="204" mass="22185" checksum="B26802434C10F5A9" modified="2014-11-26" version="1">MQGKPLAVQLGDTHGVVVYHAKTLAPEKLCAAFEKYGKTSVLHGFVLTDGNYATVVFFAEPLICATCYASLSRLAQGPENIGIVDVGWIHENGVDAFAKRPYVRHKYAPAVSTVDAGVSESNGYLVAYWKGVAEADRCEIAQMAHSSAIEVFEDSKEGGRLFLRFRSEDAADAFHSEVLLKFTAMRRSLSYADATDFLLAKGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SIB2</accession>
    <name>A0A088SIB2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_332710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702362.1">
        <property type="nucleotide sequence ID" value="XM_010704060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SIB2"/>
    <dbReference type="GeneID" id="22578424"/>
    <dbReference type="KEGG" id="lpan:LPMP_332710"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330035000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_332710"/>
    <dbReference type="eggNOG" id="ENOG502QTEZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273455at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="950"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="976"/>
            <end position="998"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1059" mass="110860" checksum="8F2EAFF966B6B16A" modified="2014-11-26" version="1">MRDREVTECLLGAEQWLRELNRPLTSASVSGSANGGGSSSSISGFLPYVEGDALLSAYRSALSELRLLVLGVLNTMPWWRVVETVADHPTVPQSHGVRGASISGRGHSGGGAVAARTATQHGSVSDRSVAALHAITRWHVRLQIAFERVCLTLIDQSQKTVRGVLEVLLKPCQLRPPVRDGARRSIPSDSFIRVLNAVATKYSPNYVVELLEGCIADFMPRQRWAERRHHVACTAVLLYVALEGHTPAYHPRLGNSQSLQRALELLKALRSRHTDNSNSVGDSPWQLPPATRSHSLSLPGGTSEESGTDLGGSSSAVSAKRQGYHASLSSMLPTTGVLPSGYVSATLLEGAKVGEAALRQPILPHASLVGSSLSLIETTTTASDMELSDGDAHGSDRARSAVNSRLADNPSGRYVTAACAGGGGDSDSSAATVVCRKGRSRGAAGQLSGEVGSGVAVAPGSAAADGAPSFLDVTVEHNNKLLSYRNDIVRVLLNRLLDVELTLEPKDMEEKQGGWSRVMGVLGLGGGGGSSSAMTVASHQTSFRGSPFGSPPASGLGSPASVLSASSSSLPGVGGGGSASAFPSIPITAADAGMLRQVTAPTSDLSSPAALSPAVFLLPRSDSLGFSGGAGLGDWGSAASPGASLASTQPLEHLFNTLSQPYLRILRDCTTLVYGRLGDDLRRQQVAGSCGNADWWVDIVYFYLTVVTRVDRPVYVLYLAPSLSMLGAEDESIGLLHKLITVAIKGSMPVEQPRSSSTISGTLRCPSAMWASSATASVVSASSLPLSGAPVQPVRLRMAPPTGTNRRVVTMEERLRAARHIFPLFRFLQSRIDEASGEGVRRRLLKWTAQELRRLGGCSASAMGGGGGRGGSLYVRSHPPPSRETRLALVTFAQCAAISELMGVDVVPQLSSAGKSTCGSARFTSSTAYGDTSDGIAAALEPFLSRYTLQSEPPAEDMEDTVTTADDGENGNSNCSAAASSASLSETLSSPSASASSSMQGAEQAGRKASEKIAGTTASAMSLSTLCDTEQKPRRRRIDLRQMEFEGLLQPQLMAYCPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SIB7</accession>
    <name>A0A088SIB7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_332760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702367.1">
        <property type="nucleotide sequence ID" value="XM_010704065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SIB7"/>
    <dbReference type="GeneID" id="22578429"/>
    <dbReference type="KEGG" id="lpan:LPMP_332760"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330035500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_332760"/>
    <dbReference type="eggNOG" id="ENOG502S2GK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="249790at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="5">
        <location>
            <begin position="175"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO01567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="369" mass="39579" checksum="9FE09ADB369AB97A" modified="2014-11-26" version="1">MTTGDVQEDGTTASIDAALNNAIASAVKQDVDSDDVDNAASFMIAPSTSSLSSKGKKKSKDKLHSTAAAPIAGGVQYSSTITTGPKSTSAPYQPRLSSSSRSAHSGRQVIADAFKRTEPLLGGADGDYSSVYFPSGLSMNGQYKTIPEEYAEYRERNNVRCNYRGPVYVVENVCVPCNACGSPVDPVRRVPVGSLFFHETCLHCFLCRRRTGVAGLYLQVDRQAVCSECAARGYGSWVPRHEAQSRGMVYGAIRGDTYAAIEAHDRNVEQKQRRTAGRPITGGGASSTLNKATIPGVLPPSLAIANVHNHRNTSARSFALMKRQQYYTQSDNNMIMALPTSAARSPSATGGLQDITATRQYRIANGRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SL16</accession>
    <name>A0A088SL16_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Non-canonical E2 ubiquitin-conjugating enzyme C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_353660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703302.1">
        <property type="nucleotide sequence ID" value="XM_010705000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SL16"/>
    <dbReference type="GeneID" id="22579394"/>
    <dbReference type="KEGG" id="lpan:LPMP_353660"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350044700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_353660"/>
    <dbReference type="eggNOG" id="ENOG502RRXA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="406045at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018553">
        <property type="entry name" value="E2_Ub-conjug_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057668">
        <property type="entry name" value="E2_Ub-conjug_enz_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31560">
        <property type="entry name" value="UPF0652 PROTEIN C16A11.03C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31560:SF0">
        <property type="entry name" value="UPF0652 PROTEIN C22H10.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09418">
        <property type="entry name" value="DUF2009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-canonical E2 ubiquitin-conjugating enzyme C-terminal" evidence="1">
        <location>
            <begin position="5"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="467" mass="53454" checksum="2BBBDADCB7673336" modified="2014-11-26" version="1">MHFSQYPLRLTDLERQKLQLIVAALKVSEYTDDVDDFMHPYGKEGRMVTAMREFIDIVVGLAIASDAIPRPMKNSFLAGEVKVATVVPLLEDLFEIMRRHKRLNPFSHRGEFGKLMMMLQDVQKQSLQRTLEIQSTLVIPVRTVEAALSSIQCETLADDEAVRTDYLKRTRSEKQAGMQNLIDRYSQGDEHKKEVIEHCLRSIDDVYSFIQSSTRPLRTLRRCLSRDFELLPSDNVYNIAIRHGCSGARFTHSHATHCQYVTESLLLWENVQKNILNLWEAAEDDMLVAGKGQYVVANTGQGFHRMCSAPRSYAVMSRLVRDTEQRMGGWVGIKVIHLGDRDVPNPLVFIDKYTGIPPLVKPVLQTLHALRYVFHEEDEEDAAQPPVAHEYDNYPGLQNLLRSKYHSYSELMMMILSDFFKHAFDGSGDDGGSCIDGRLTSAWNWCHQLHKKKFYDAFVLTGFTGFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A505</accession>
    <name>A0AC62A505_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucose transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3520310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="XUY36864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="560" mass="60469" checksum="49C056364DF7F8D7" modified="2026-01-28" version="1">MSSKLQANDHPSDSISEKEPARDDLKKSIDDQSDAPPFLSASNAKVILVQAIGASLNGYSIGFVGVYATLFGYSTNCASFNSEQGCVTVPNADCKWFTNTNSTPFCGWTDITCRRTYTYTNLSGMPAAITQCEADPRCRWSYSSQECQNPVGFSSAESGIFAGSMIAGCLIGSMFAGPLASTIGARLSFLLVGLVGVVSSVLYHVSCAENEFWVLIVGRFVIGLFLGVIGVACPVYTDQNAHPKWKRTIGVMFQVFTTLGIFVAAAMGLALGQSISFDQNKDQMVMARMQGLCAFSTLFSLLTILLGIVMSESRAQFGGGEEGAIELDPNEYGYLEMIPRLLMGCVMAGTLQLTGINAVMNYAPTIMGSLGLAPLVGNFVVMLWNFVTTLASIPLSYVFTMRQLFLFGSIFTSCMCLFMCGIPVYPGVSKKLEVKNGVAITGILLFILGFEVCVGPCYYVLTQDMFPASFRPRGASVTQVVQFIFNLVINVCYPIATEGISGGPSGNQDKGQAVAFIFFGCLGIICFVIQVFFLHPWDDERDGKKKGSQLQEKEEIVDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A534</accession>
    <name>A0AC62A534_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Kinetoplast-associated protein-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_270240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="XUY36912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="853" mass="91439" checksum="8992F9DF57B21EA3" modified="2026-01-28" version="1">MQHHENINKPLYKIEEAEEAARIQAEAEEAARSQAEAEEAARSQAEAEEAARIQAEAEEAARIHAEAEEAARIQAEAEEAVRIQAEAEEAARIQAEAEEAVRIQAEAEEAARIQAEAEEAARIQAEAEEAARIQAEAEEAARIQAEAEEAARIQAEAEEAARIQAEAEEAARIQAEAEEAARSQAEAEEAARIQAEAEEAARIHAEAEEAARIQAEAEEAVRIQAEAEEAARIQAEAEEAVRIQAEAEEAARIQAEAEEAARIQAEAEEAARIQAEAEEAARIQAEAEEAARIQAEAEEAARIQAEAEEAARIQAEAEEAVRIQAEAEEAARIQAEAEEAVRIQAEAEEAARIQAEAEEAARIQAEAEEAARIQAEAEEAARIQAEAEEAARIQAEAEEAARIQAEAEEAARIQAEAEEAARSQAEADEAARIQAEAEEAARIQAEAEEAARIQAEAEEAARIQAEAEEAARIQAEAEEAARIQAEAEEAARIQAEAEEAARIQAEAEEAARSQAEADEAARIQAEAEEAARIQAEAEEAARIQAEAEEAARIQAEAEEAARIQAEAEEAARIQAEAEEAARIQAEAEEAARIQAEAEEAARSQAEADEAARIQAEAEEAARIQAEAEEAARIQAEAEEAARIQAEAEEAARIQAEAEEAARIQAEAEEAARIQAEAEEAARIQAEAEEAARIQAEAEEAARIQAEAEEAARIQAEAEEAARIQAEAEEAARIQAEAEEAARIQAESPVVGRVSSDTDVEGVRGDISVNAAMLEATDIEHCGGYSRTVQRRMSKHRRASFAAHFVDKPLSGGAPRSVAPMALVVTESNQKGQFVAGFFFAILAVFAVCGVMLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A597</accession>
    <name>A0AC62A597_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase M20/M25/M40, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3320430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="XUY36751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="472" mass="51182" checksum="D9528480A5A26E51" modified="2026-01-28" version="1">MGDCDWTVIQKAVGAEWDASIIPALSAYIEVPNQSPDFDPHWATNGLMEKAFHILIDWVKGQNLLGLSYEFMEVEGRTPFLLVEIAGTERTNNTVLMYGHMDKQPPLRPWAEGLDPHKAVMRDGKLYGRGAADDGYAIFSAITSVSVLQRHGIPHGRVVVVIEACEESGSFDLDYYMAQCKERIGNVDLMVCLDSGSLNYDQLWLTTSLRGVTGGVLNVQTLTEAMHSGVAGGVVPDTFRIARELLDRVEDSKTGTVLLPEAHCEIPDHVAKSMVSMKSVPFKQQFAMADGVSAEPGDNVELALRNFWKPSLTVTGANLPEPQIAGNVIRTLTSLKLSLRLPPLVDSGKATQAMAKLLTTNPPYGAKVWFEPEVPGDGCATPELKPWLSNALNEGSKMAYGNPLAYQGMGGAIPFISTLTKMYPQAQFIVTGVLGPKSNAHGPNEFLHVGYAKGLTLAISHVVAAHFLLAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5U7</accession>
    <name>A0AC62A5U7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tuzin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2020180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="509" mass="57556" checksum="536E3C0681AA3FD6" modified="2026-01-28" version="1">MEGAPVSAVAEVSTRVYVQVGRTATNEGRVVGGIVGRVNSNGTLGVLMDKSCFAAQVSQDDLVLVEGRARITLERGYLDMVKWIRDAGVHRRADRERLSSVLYQRGWRVDRLYLLGPSDVHCVSYVKRSVRLLVLERAEWQRDHHAELRALQRERVRERAWRYVIQRYSGFVSANWAALGVLSVFLWNFKSYRRYQRSFQVKRAVSTLTDTDQQYTSSPAEPPPFVERAAEESWARQVLRQPDITHPRIAVVTGLRGCGKSSLLRSAARKEHRPALFVEVRGGEDTLSCIVKAMKVPNLECCGDHLEFIADTFTKAAKVHGERPILVLTLREGCELSRVYNESALLASDRRLCHLAYEVPLESLTTQNVLLPRLDFYAVPNFTARQALQCTEHAVDATSMLHFIEVMGTNCSDIDELLAAVRHRGVSVVDYIDQRLLRAMRRAEAAWASSGTLRAAVKRLAEAEYYVGQQNGPGVLRDAELKGIVLYDPVRDRWMFTHKVYHTAARCCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A635</accession>
    <name>A0AC62A635_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amastin-like surface protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2021170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="195" mass="21821" checksum="4422187F17640540" modified="2026-01-28" version="1">MEFNPFIIVYAAIQFIAFLLVLVGTPLDIFRSRQRSIFNETSCVLLWGVKRNCSSIAYAATSDDRWVMCPTRRTHFRVARVFAVITIGVYCAAFVLGFIMLCCYACLRWVCLGLNIVGFVTLATLCALMVVSYETDAYPLCPKLKNDFTLSSGFFLFAAALCLDLVSIAFLFIPWSHENVEGSSSHSKEGNSQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A640</accession>
    <name>A0AC62A640_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amastin-like surface protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2021040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="179" mass="20041" checksum="4D6F629CE401BA8F" modified="2026-01-28" version="1">MEFNPFIIVYAAIQFIAFLLVLVGTPLDIFRSRQRSIFNETSCVLLWGVKRNCSSIAYAATSDDRWVMCPTRRTHFRVARVFAVITIGVYCAAFVLGFIMLCCYACLRWVCLGLNIVGFVTLATLCALMVVSYETDAYPLCPKLKNDFTLSSGFFSSQLPCAWTSSALLSCLSRGRMKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A664</accession>
    <name>A0AC62A664_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amastin-like surface protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2020880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="194" mass="22191" checksum="6A5C0B5FCE518DDD" modified="2026-01-28" version="1">MEFNPFIIVYAAIQFIAFLLVVVGTALDMFRLQSRENFEDRPCITLWGLKPYCNSIVYSLSSDERFSLCPVRRKRFHMAQILAVVSVGVYGTAFALGVIMLYCCLHLRWVCLLLNIVGFVILPIPLALMVLSYKTDENSLCPKLRDDYDFGVGFYIFATAVGMDFIDIVFLLIPWQYDYLDVTCNSKEGNSQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6M8</accession>
    <name>A0AC62A6M8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Surface antigen-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0920290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="XUY37346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="125" mass="12520" checksum="865C57B86962E871" modified="2026-01-28" version="1">MTSTRNKFLLALVALVLLATYAAAVKGDCSVENCATCLEEDATQCAECNNGYRPTDAGQCEAISCDVPNCATCAAGSTTQCAECNADYQLTTEGQCVAASDAAAAPHSGVAAVAALAAAVVAYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RH54</accession>
    <name>A0A088RH54_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GYF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_010040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009370">
        <property type="protein sequence ID" value="AIN95105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696647.1">
        <property type="nucleotide sequence ID" value="XM_010698345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RH54"/>
    <dbReference type="GeneID" id="22571733"/>
    <dbReference type="KEGG" id="lpan:LPMP_010040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000031100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_010040"/>
    <dbReference type="eggNOG" id="ENOG502SM7T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265028at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GYF" evidence="2">
        <location>
            <begin position="127"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="186" mass="20466" checksum="73D1F947DDB5A63E" modified="2014-11-26" version="1">MKRARSLSADGSESAPEPSTASLSSSAVTDLSPSSSSSLLAVEEYEEPTATPLLSILQPVLAHLKERELFADALRRYSGAKAAAFDALAQLHQAAMTQHAFVMMRMTREAILLRALEEARRTGIALPHVWMMRWKAKPTAEHGPFDDDVIQQWGRDGYFGKKEAELCDINGVRKYWRPALSVAPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHL9</accession>
    <name>A0A088RHL9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutaredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_050310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="AIN95472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703794.1">
        <property type="nucleotide sequence ID" value="XM_010705492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHL9"/>
    <dbReference type="GeneID" id="22572109"/>
    <dbReference type="KEGG" id="lpan:LPMP_050310"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_050007800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_050310"/>
    <dbReference type="eggNOG" id="KOG0911">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="415696at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03028">
        <property type="entry name" value="GRX_PICOT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000357">
        <property type="entry name" value="Thioredoxin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033658">
        <property type="entry name" value="GRX_PICOT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293:SF16">
        <property type="entry name" value="GLUTAREDOXIN-RELATED PROTEIN 5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="6">
        <location>
            <begin position="93"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN95472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="180" mass="19662" checksum="E46FCA9DEB84EAEC" modified="2014-11-26" version="1">MRSMSRRLPLSAGGCLACAPRGLPPTASAALAATYSSTSAMPFSSLSLPMFTAAQRISAAFFHTSPVHRSPSDVAGDLAKDLHDIISHDRLVVFLTGTPEQPRCRFTAQLVDLFNQLGIKYTFFNIMDDDEVCEGLKAYSDWPTYPQVYLDGELIGGYDICKKMMLDGTLTSMLKAKNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RI51</accession>
    <name>A0A088RI51_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_060120</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the proteasome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703895.1">
        <property type="nucleotide sequence ID" value="XM_010705593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RI51"/>
    <dbReference type="GeneID" id="22572218"/>
    <dbReference type="KEGG" id="lpan:LPMP_060120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060006500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_060120"/>
    <dbReference type="eggNOG" id="KOG0179">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268479at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03757">
        <property type="entry name" value="proteasome_beta_type_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000027">
        <property type="entry name" value="Proteasome subunit beta type-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN95573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="247" mass="27860" checksum="1F9797CEA9DE99C4" modified="2014-11-26" version="1">MIEDHAEYGHNYYPKKLANTVLTLPQQGAKQQQWSPYQDNGGTTAAIAGNDFVLLAGDTRLNGNFCLHTRHDESKIFQLTPHTYMASNGMQADRLQLQQLLKYRIKWYRYNNGGKVPSTKSIAQLLSTVLYHRRFFPYYTFNMIVGLNEEGHGVCYSYDAVGSTEPLLYGTRGSAASFVEPLLDCLINRQHMTCQAPSEMSKEEALVMLKNAFTGAAERDIYTGDSVSFITITKDSVQQESFALRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJJ6</accession>
    <name>A0A088RJJ6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PSP1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_100090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696731.1">
        <property type="nucleotide sequence ID" value="XM_010698429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJJ6"/>
    <dbReference type="GeneID" id="22572745"/>
    <dbReference type="KEGG" id="lpan:LPMP_100090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100006100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_100090"/>
    <dbReference type="eggNOG" id="KOG4679">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="241863at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047767">
        <property type="entry name" value="PSP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830:SF19">
        <property type="entry name" value="PSP1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="2">
        <location>
            <begin position="256"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="376" mass="41361" checksum="598A67C7EB2A65C7" modified="2014-11-26" version="1">MFQTYPLADCTRDTIQAMNQLHDLSHGGSAMKSAKIKRHNPYASKLLAPEDSVEYNSMFNSPLSSRQSPLNWEARAFDPSIMYSGISTPYLTQSLASLPMELHVRRSLFGDSTAALPGNSPSGASTELGDSRAQVTIAPVAQSSVAAPTKKTLGKVYVGGCPLVVPQHDNEVTVQLRHSEATFVIPDIYSLMALEEETRDMVGMPVIVEGDRGEDFGVISGMAKAEAATGTAAPSPKTEEDAAAKVSPSCSAKPLLKVLRVASSLEVQNREALLQREAEALEYCQACLQEVQLSVPITIEGVVFQFDRKKLTVRYTSNAYVDFNDLTRMLHKKYNCRIWMDQLNRDTVNTEKRSRRGEQSGKKGNQHHRGAPKRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKI4</accession>
    <name>A0A088RKI4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonuclease mar1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">MAR1</name>
        <name evidence="3" type="ORF">LPMP_120070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009381">
        <property type="protein sequence ID" value="AIN96335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696988.1">
        <property type="nucleotide sequence ID" value="XM_010698686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKI4"/>
    <dbReference type="GeneID" id="22573013"/>
    <dbReference type="KEGG" id="lpan:LPMP_120070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_120005600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_120070"/>
    <dbReference type="eggNOG" id="KOG4044">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269496at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050993">
        <property type="entry name" value="Isochorismatase_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119">
        <property type="entry name" value="HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119:SF3">
        <property type="entry name" value="ISOCHORISMATASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="2">
        <location>
            <begin position="13"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="192" mass="21559" checksum="C37C588527244512" modified="2014-11-26" version="1">MSRLIPHYSMGKTAFLCVDLQKAFSKRIENFPNCVFVANRLARMHEALPENTKYIVTEQYPKGLGHTVPEIILPKTAQVIEKTRFSCIVPEVEKLLKDVNNAVVFGIEGHACILQTVADLLDMNKRVFLLKDGLGSQKKTDFKAAVKLMSSWGPNCQLTTSESILLQMTRDSMDPNFKAIAKLLKEEPPIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLB7</accession>
    <name>A0A088RLB7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exocyst complex component EXOC2/Sec5 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_140230</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697258.1">
        <property type="nucleotide sequence ID" value="XM_010698956.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22573290"/>
    <dbReference type="KEGG" id="lpan:LPMP_140230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140007300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_140230"/>
    <dbReference type="eggNOG" id="ENOG502RDKA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273295at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029175">
        <property type="entry name" value="EXOC2/Sec5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039481">
        <property type="entry name" value="EXOC2/Sec5_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13043:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13043">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15469">
        <property type="entry name" value="Sec5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC2/Sec5 N-terminal" evidence="5">
        <location>
            <begin position="4"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="157"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="500"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="648"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="832"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="870"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1666"/>
            <end position="1721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1789"/>
            <end position="1830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="512"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="655"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="676"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="832"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="870"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="881"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1696"/>
            <end position="1721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1813"/>
            <end position="1830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF15469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN96605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1830" mass="194931" checksum="92AAA62E9A160D2D" modified="2014-11-26" version="1">MDELFGENDDHRQPPLDLTSRAFQPKKYIQRALANVSHSVFEGQLIDKVGVAEAETGEALKQLIRDNLGVFINSKDAMDAVYNSDAELFTGEALEGITTSFKNALNICDSLVQPITDTFLEMQESRKSQDMLDKFFSVLGVPGAIYNSCGAKVAQRRQTAAGNSSSSYVDEDGASREGDTGENLGSSSQEDQSKKASRRAVKRDASGDYNDDGAEEDNEDESDSDEDSSPAAAAAAAAAATAKAHGNLEAPAGSTTAADMYVLGSGEEIHFWCGTPLVRLKDADAWRQHVNHVSNYEVAVLHLRRAMLYLEETYSLIDGTMLAGDDEEPLKTVQVSLAAGDNHSPPGGQGSPAAAVVGAAAGSSKNVSAVGHSVFAYKFSMALLRASLYLCSQLAEELIYANPADTVLIEDTLSMMMDTSIASVKLHHFCAVLQEALGEGDQHEQVLTKLRTQLSSGGTTAEGITLKGGSTAAAVRLEDSSFHTTASLSKLGDNSLSFSPNRTVPEASTDGAVPASAPSVTAPRHSTTAYQHPAQFFISIVQRQQRHLFHSSAASLLRESSGWLWKAQTDAARGLKERQRQQALRHRQCDAADVGEGTMAEVLGGNGASGFGLSSSPFVGASIGSDGGFIGNTNDSFRQDNSFTWLNARGGAGRHQSSAVSRTSGDGDDSGFAPSGSATALSGGNPTDENRRFVGIIPDAYVSRVLDAFNTPESPFPTSTEFRVGALDMDAALVSSCLQIRMHSSSLLSQLFTRADVESAVMAQSSSLNTFALRLCAECVGTLEHVIGSYWGGIATTLHSGVFDFAPEPGSPLHAILTQLLDNTGAQVVAGTGGAATSGSGSGGKRLQPSPSTILTGTHLRSLSHAGEMDDNADVSEDEPAVTGTANRGAAAGDARGRAGGAGVASGSIDHLPRIRFVPTLPHVFHPAAAGVSETSAAQQPTHPKSLRDISVEAVHHMISNAAATLQTLFLAFINRSVMDGFVSTLALYRVSDLHRYGRSERIELHAAILYEVILGQWMHMMNLVSDTMLRLKIVIGDSSSSAIITTGTQVEEVGRLLQELELLRSTSLRCYLHGIGVLSKAYLTALPLLQRHTGTSLDARIRARLSRESVSSNTVHKLLNVLSVAMDRCVPFFVRDTEVFNSVDLFALKSENLRDDADENVVASGRSGGGAGARDAAARRRRVLRQRLGDDASGAARYSGKAASSGPAVLGDGADTVADPISELIAQFHRKLVMESLQDHEELVLALLSHLLLAFVDMLQLKCRTATTDVTLHPAERERCVVECMADTLCLATTLTPILTEHLLTPCFFEVIVRQLPELCATPVDIAAMLHSKQQQYSQVYLSVVEEHCQLAVDAMMNAYLALAQQPITDLVRRQGFVQPLFDWQRVSPHTTAAVRPYIADAIACIAHAHDTLNAIRQPVLGSTATQRLVGHLVRTFLTSFTSDVNVFELSVECSSSFLVYGLTLLEAEAATILRVVDAVVAHVAANPTTNELLSELTIARENLSTLTQTLEDYATSVSEAIVAARSSEGGGASGADIALTLLSRDKRHERRDGMVQAAMRTLDYMLEAINTELEESSLSSAALLQLRSAAAATTEGDGAAGVGLRSNVAERIVLRIERRKEGYELRRARAAVAVQDELQRQDIKKRAAEQQSEQKAAAVASALLEGNTGPADGSDNGTSLLGRRRLPPTSLGPGDDKNGDVDSGEHLTPRTVQESERASLKAAEAAGNVFRLAQDQQEKRRVRRLRKTSTDEGGSTDEAVAAVEVSAGAAKVRPTPAAVPLSLSVPLAGSEVGGKDDDGGKGAEAVTTRNRVSRHERRANRFRRTNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLD0</accession>
    <name>A0A088RLD0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_140340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697268.1">
        <property type="nucleotide sequence ID" value="XM_010698966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLD0"/>
    <dbReference type="GeneID" id="22573301"/>
    <dbReference type="KEGG" id="lpan:LPMP_140340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140008500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_140340"/>
    <dbReference type="eggNOG" id="KOG1620">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2573163at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000828">
        <property type="term" value="F:inositol hexakisphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF104">
        <property type="entry name" value="KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="72"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="257"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="455"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="526"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="847"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="468"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="541"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="857"/>
            <end position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN96615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1055" mass="114387" checksum="5810A0AAB439A515" modified="2014-11-26" version="1">MSERTRDITLEAVEPFNCIECKPNTSKTEESPKSPTPLLCDVNNVVTDALRLRNSSDELDGYCSSCEGSLPDISVSSSSEPTSRTALPTSVAAALHRNSSRQSHHRRRRYRGRGSPIRSAARDEERQRLVAISLAEPMETAETKGELVQSTDSATTTTSSPVKEASAVSEMEEIARESAFNEIPMAYPKSIAAATGRKTSLTMMSVTLGIGNRTPKTAKRSNSNSPHTIPRSAVGDMNDTMLLQIPTPILVQDEEGESTRLLHSSTVSQPPPSSRGNSNAVEASIESAVAERFSVETSPTEMPRPRAPSPTGTLSLAGSAVITSNGNNTGGDSGTLGMGNALRIKSGGTAVLPLVVEPSRVAPAAAGLMKSNMVNVDQGSVTHTTASHPVQGTFQDPSAEPQLDKKQFIASVDKTATGTTGVAVQGTHMPGVATLKSTKVAVLAHNVAAATSAKHLQSPLGSPTHVDLSSSSSVGGHHLSVTEGNAFLKQSGSRREEAFYNMIQPYQEALVREAVRQAPHTVEHWNHNNAGTQRAGVQEGAASTFSSSPSKARHHSPPHTSAGRRQSDDNGDGALADPDDVAAMYEARWEAYQQYEAEDMSNLCILASEQLSERNMGREHRRSGGDNKCAGPLHCGSSLPVSPHQVDKDLIELAARLWWTVRFRHFYRTSAPAYEVQRQAAEAAGLLQPSPSACSPAVITPISDEAAIANSRCSAPASQHPLLLPRPALPTDPSVMKQGKAEHREETAAVGVTAPPTLTPSVSGTATPCMVGSFAASLLEGVATRDSAVELQYAAQKHRALQLLASFVPRYHGTHRLFMRDVLRCERKGRATVASVALQREAGQWPQGGRQQIVVDADNDDDDDNSGSDKRVCMIMLEYVCYRFRHPCVMDIKMGSRQYGLHPSAEKKRSKERKAKLSTSARYGIRLAGYRLWKAEEGQYSFRGKLQCRSLSFNEVKSELSTFLFHSHEMKRVFCRQLQRLRVAFSQQTVFRFYTSSLLFVYDAEDPLATARVTMVDFAYTYESRELLQGGDPDAHYAYDFRYLKAIDTLLSLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLD9</accession>
    <name>A0A088RLD9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_141420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697371.1">
        <property type="nucleotide sequence ID" value="XM_010699069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLD9"/>
    <dbReference type="GeneID" id="22573409"/>
    <dbReference type="KEGG" id="lpan:LPMP_141420"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140020200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_141420"/>
    <dbReference type="eggNOG" id="ENOG502R7CE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276037at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN96718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="670" mass="73835" checksum="0AF3026F210D89C1" modified="2014-11-26" version="1">MEGVEWGEGEEELTNYLREEYPRVSALPVRIRYRTFAQPTQDTRIRAGRSVHDFYLYRRRRLDSAIDAELTACGIPVVQPLQCVLTDSFAIAQRQQATYQWLAQRHTADEILHRFAVDRKLNAVPCLAAVNRSLSVLGRDGRADAVLDILEDVLLDTNIIPLSTLLGAIKALPNHPVRAARVALTFKGSLGSQTVPPSVWGNLSAALAQASLQMPKPLEDHFMELFERVLAMVSASTGRLSESLIVAFSRCLLSSSKPCSVAMHLVREELLSGRSRDGFTSAPLHLGAFLSDLLVQLCCDDAKLGTPRHCSSDTDTLTFACDVIKYAFAVRVQLAPRVFDEVLALCERRKEYYRMCILFVSMCVLSTPSLVSLLRVLEVVTQICELRAPLQRLLPVSCTCFFLWCLQRYPGLYQSPVESQSQHNATRQVCALLGTLAVEEKNAEKLPALLRFLTQERGIASTMSANAVSAAVRRFRELRCPAGKAVYADLQGQNEAILAAVLEIPQRPTNPAVSPRASTVTVELHQLLPSESVYCTVLSASALGTLASCPVAEQAFVRMMESYQRKCGAVALLPFESLCASFGLPHGAVGMLRTWHREYTWLAVLPLGLSLQLDGATSCEVCCAAFAATRQVHKRVMLICGNEAEVLTAKEKKVEPVIVMETLARRLSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLK2</accession>
    <name>A0A088RLK2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_140750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697308.1">
        <property type="nucleotide sequence ID" value="XM_010699006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLK2"/>
    <dbReference type="GeneID" id="22573342"/>
    <dbReference type="KEGG" id="lpan:LPMP_140750"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140012700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_140750"/>
    <dbReference type="eggNOG" id="ENOG502SK96">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264758at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="405" mass="44180" checksum="F446DA580CF58CA9" modified="2014-11-26" version="1">MTALATSSSAVSVRRQRGHGRVSLRALEAALLLALLLLEAFSSVALIVNAVKGHHATVRDDARVQSVWLASAAAAAASDMRESNVHVLRKMNQQNWHLLDGDQLIPGDGKSVAHARPLRGAPLTGVCEGPPECESPPLPRAPQTHSDAGRHSKQAGVHPRDHTTSDAPQDAAPVGQHHCRTKHPARVTSSLHQQHKAAAEYAGTEPPRISLDSLRLVIQLEDEVATKEDNVEVHEDGDDKHASPQRRVPHHSRRLRENSAHLHSRDYGHRRGRARDSNAHRHHSFLALREQPVSGLRRLAVEQHAIEHHSDGDGAAEVVSTDAKNVTSMTESKEERQRRCLVVNTQDSKAASMESLREGTPRKCCLIVPAEVGNDIPSSENNAKRTVAIMTLFVSALFGAFLFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLN1</accession>
    <name>A0A088RLN1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tub family protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_141120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TUB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697343.1">
        <property type="nucleotide sequence ID" value="XM_010699041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLN1"/>
    <dbReference type="GeneID" id="22573379"/>
    <dbReference type="KEGG" id="lpan:LPMP_141120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140016800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_141120"/>
    <dbReference type="eggNOG" id="KOG2502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8775810at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.90.10">
        <property type="entry name" value="Tubby Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000007">
        <property type="entry name" value="Tubby_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16517:SF7">
        <property type="entry name" value="PROTEIN KING TUBBY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16517">
        <property type="entry name" value="TUBBY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01167">
        <property type="entry name" value="Tub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01573">
        <property type="entry name" value="SUPERTUBBY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubby C-terminal" evidence="3">
        <location>
            <begin position="306"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="267"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN96690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="403" mass="43235" checksum="C4190ACE0B479770" modified="2014-11-26" version="1">MNAVIPAKLTEDVVRCAFGSDTAPSLASGAVAGESGACPGSGRACSIIMPTCKEGSDAASMYSMSQSVLPMDPRERIYYRPRRHLLQCYLERRKLKGHGITSLLPGTRKSFQFFLECTNDFVLAAVPRSLRSRIKVEDTSSGASGQLYPVTQGGTNIVFTINQQQLDGDTRSFVGKLSRRGNGMEMVMFSEGSKATRKEILAVLLHNFADTSQSSLTVLLPAIDPASGYIKPLEGGEVKFLRNGRGSLGEATENSDDDVDPAYLTTSSAAPSSVPVGDSSRANSASSLNSGETCGRQKKRCSHGVLASEYRRSPCSPSIVVLNSKTPEWDGVLRGHKLDFHGRATKASEKNFQLVAASDPGKVVMLFGKQSDDRFALDFRYPLCGLQAAAIATTVMTARKAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RM67</accession>
    <name>A0A088RM67_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_170890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697780.1">
        <property type="nucleotide sequence ID" value="XM_010699478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RM67"/>
    <dbReference type="GeneID" id="22573832"/>
    <dbReference type="KEGG" id="lpan:LPMP_170890"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170014800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_170890"/>
    <dbReference type="eggNOG" id="KOG4308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="341587at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="676" mass="73301" checksum="D2D2B90BFA13791F" modified="2014-11-26" version="1">MLNTTLRTKRSIVAPQLQVLAESEFHSTRMQEQLRTQAMKDFSATEQQVAPSYFVPSLQELCAQRLADRFAENAEVDALREEQPALYAMVLERLPVQPDTVLPLRITVPRIIEEKYWQRCCKARWSLGQLSRMTKGQRLREKEYGWKRLFLEQVLSDFLMALGSDSTAGDGDGSLLPSGAMTGITGRVLAASQKGTSTLTSASTTCTSHDADASRFDLSLDCEAVAALRELCAICRDYVHTVDLPCQLVHFRPYEHLFAHMPGILSFRLTFGVANRGVRVGVTDMIGFRDEDAQLIQQLLRNYTALESLRLPLNRLADRHVQMIAAGLANSTTLRVLDFSQNSLTDASIVEAVSLLLCRPDFPLEELYLVDNQLADAAATALAEALRYNKTLRVLHLQQNCIGDAAGGARLVRSLAVHPTLADISLGSNRLGPSTAAALSEVLPQLTQLRVLCLSGNSQLFCAEVSQSDFSSAASPDGGAAGMTVAATGSTTSLPSVRSAGLSAVSAKDNDAESVETSAKDVAEAREESEEDEADVSLTPSGSATGEESRATVTARSSMKTVAGEDVPALLHEGPHGPRKQKSASQLLSSVAPPPLAPMTGGMLIAAAVKANTSLVELDVRFCGLTPAEEEAIIRVVQERMYQHRMDTSLSFEAVQRRALQRRAEERVARMTGRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RM88</accession>
    <name>A0A088RM88_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_111250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696972.1">
        <property type="nucleotide sequence ID" value="XM_010698670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RM88"/>
    <dbReference type="GeneID" id="22572990"/>
    <dbReference type="KEGG" id="lpan:LPMP_111250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_110016900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_111250"/>
    <dbReference type="eggNOG" id="ENOG502RZMH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="409644at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042856">
        <property type="entry name" value="RSP14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15599:SF1">
        <property type="entry name" value="RADIAL SPOKE HEAD 14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15599">
        <property type="entry name" value="RTDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="402" mass="44612" checksum="8DF837EB1B52737D" modified="2014-11-26" version="1">MWSVIRRHQGLAPNKSPVRHDSPYSAHQHCIQLHAVRPDVSYMSPTAFSKAYGEFLYVKIRRWLLDERIDVRLQAVEHLVELYKEKREHCVQSLAYDMLPILLSTLEKDESTALRERAGMALELLVRELQTQRLLLKGDFTEDAPFSLSTGKQTSPLPHLGAILASLRDERDEVVVAGLRVVLACHMWQNSFAVTAALVQGGLISVLIGLTQSTNISAQTLACSAMRQVFQVKEAHVEFLKLGGVVTLTEAIANTDALALVAEAAEVASLIAEYAQGRRDAVACGTLAILFPHLPNPNLTLRVAVYSAAAQITVLEAAKIQATEVGYPEQLVREMASEDERDVLTHMLRLIYNLAEWPTARLTLRACLPRIAELMRIVEDDDAVVFALSQAEKILKKKVLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMF2</accession>
    <name>A0A088RMF2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinesin, putative</fullName>
            <ecNumber evidence="3">5.6.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_161550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.3" evidence="3"/>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN97030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697683.1">
        <property type="nucleotide sequence ID" value="XM_010699381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMF2"/>
    <dbReference type="GeneID" id="22573734"/>
    <dbReference type="KEGG" id="lpan:LPMP_161550"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160020900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_161550"/>
    <dbReference type="eggNOG" id="KOG0239">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264170at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="KINESIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115:SF1006">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="2">
        <location>
            <begin position="13"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="105"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1086" mass="120348" checksum="3E01589F7F83B0B1" modified="2014-11-26" version="1">MTMAGGGHCEMARVTVSVRVRPKLAHALNPLQQSERYEEVVCIPSSDTSLRFTDCRATKDTRHLHFAYDRVFDMDATQEDVYEEAALDCVEGVLAGANGSILTYGQTGSGKTFTVLGKTTTIHDGTEAVQAVGAETGLLLRCIEDMLCFAERMRAKCERHVVLGMTAFEIYMDKIRDLLHERVDRQPLQPIMTRDTLYLPHLTHVPLRTLRDACHVYERAAARRVQRVTSANDTSSRSHAFFTVEVFQTPITPTCPSSPDLAECCALREAQWVALTAVEQTRRGPRPLRSECFEGAANALLGTRAVPVMYSTLTVADLAGSEKAKHAGVHGTGFDELRCINASLTALGNVVHHLFHGTPHIPYRDNKLTMMLRDTFAAPRAQVVLFVNVSPTAVTCEETLSSLYFADKIKGMAVPATDSASLRHGALQSAYLQSLRIHDVLLSEARIFQAQQMYAAGHLYRMSAAVSQHPLFQLLFHIPLTSGTDKEAHMNRLCAHLREQRVHEGSPEARMDSLIEAEREELCRDMVREYSQRCAEADAQTTAVDEASTHLRAQLSCDASALRQCLAKAEESTVAIAARRCGLTELRRTKLEELQLLRDSVEALDEGEVGVVDACEVGANDQVNTAAFEQERVTYTKALELTQLHLTLLELMAPCATPLPSAQTEGESAADHCLRNSTSCNRSDMSFTTAASTTSKSVSVEAWLRGAVLVMAGNAVEQSSRKHPGKQQRQTRRQLVSLSKSLNIFSNVTNPNGGIYSLHKYWCVYRRRERTDREETDANACAIASDAAEKDTSSMARQRSSFDDPALLTRVMAHMYMGTSLMKLDRYGRPNARWFYLSQRDNRLLLCWDESRRVLGLTGVGHVSLDAVVKITLGRSSPGFRKYATRAYKDQVGDFYTSFTLTYLTRASGRNLKFVDVMCPDQAEMETWVVGLAQRTGVFPCFEDVCQPVGSGNGGEEEAAVTGGTVVAVENTDAAAARQAQKELSATEKVLCSSWHIPAQTMLRARREIETRRQRHQSSRLRLSPSELRDLTALDIFRASALWQHLYREGSVVNSFKELHCYVSDQSMSAEPAPGLLPRATSLRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMG7</accession>
    <name>A0A088RMG7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Surface antigen protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_120760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009381">
        <property type="protein sequence ID" value="AIN96404.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697057.1">
        <property type="nucleotide sequence ID" value="XM_010698755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMG7"/>
    <dbReference type="GeneID" id="22573082"/>
    <dbReference type="KEGG" id="lpan:LPMP_120760"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310019700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_120760"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN96404.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="443" mass="47308" checksum="16DD3EEB0AF42367" modified="2026-01-28" version="2">MHLCRALSAEGSRARHRTPLCSSGRSSKHPLDRLPSRLPIHPHAFLPFSSLPCATLALRLLAPFTSSPGYPRSEVYDAVCAHPTCSRPQAPDSPLVSSIASLPYPTSHAYPILAVAPLASCRWLEVMRCTRWLVLAAILAAAAVRATVTGDFTAEQQSNTLAVLQAFAGAIPELQSTWSGSDFCSWGGVTCAVSSVRVAGINAMYAGTLPEMPAGVDYTNVMITRLDFSTMARGLSGTLPDSECDRRTLARSSPLHASSWCSSRRMRGRPPTGGKWESCATFLCASFLLTVARHSAGRRGRRRGGGEAVVFCSFLPSASAIVIAPASTALELPLCLRRGPSVPVAPSLSLALLPLSTSPEHAPLPIRPPSCLCSPLPLVVPLFSALLTESHLGLLCEVLVGFLVTCRGPRKAGRAVPPWCLVRTVRYCEESFWKASRKEVSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RN87</accession>
    <name>A0A088RN87_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_140860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697317.1">
        <property type="nucleotide sequence ID" value="XM_010699015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RN87"/>
    <dbReference type="GeneID" id="22573353"/>
    <dbReference type="KEGG" id="lpan:LPMP_140860"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140013700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_140860"/>
    <dbReference type="eggNOG" id="ENOG502SI79">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="252252at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="580"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="631" mass="68703" checksum="DE726B219E27FA9E" modified="2014-11-26" version="1">MLLTKEEVQTITLNAKSVHKYADQAFFPAEINKAGTHIGDQPFLNFFVRYHHRYAPEQYSWSRVRRVLLLEDVMAAHNSAMASVVTSPTIEWRSKTFWVCFAVETVQPRSPSSAASNDTVEEEIVTLPQLSNTPPTEDEVLAFCVASANQRPTEVYADGVLGEAPAAPAVNPATNGSLPQPAGGEAADQAPPPAALDPRLFVPTPRQVELLRQYKKQHLTHHQWTEDEIEESKMLRQRYCNTGVATAPVRTVAYLQHHRVEERKQQQQRRYMFGAASSAAATSQSAERNALRGSVVSTAAESTGGYAVTQRQRSPPSAVTSTSPFLPRSVLRAQNHQLHQASAASDLKQRIPADGTSSVLLLGDSASGFLSQVSVSHTPPPEEQAPTSMQSGSLSALSQHLSQLRAAEESFYQYISDESRSAYLNRLADLTKRNSETNKRNRRRGIANERRLERKGNLLVSCGLWITDDKERASKAEDYVKAQAGDSSSSKKNGESATAASAVAGGGASGDGADTAKSAEDVFVERFKAYYNAQRISFADCADSDLFASSSDADIGPLLQATAAPDADTEPDKPHLACSAGAATDALRPGRRPGRRLLPNRLRTEENSPALVQAQLVHRSTVRMAKRAREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RN96</accession>
    <name>A0A088RN96_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">S25</name>
        <name evidence="6" type="ORF">LPMP_200450</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS25 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698244.1">
        <property type="nucleotide sequence ID" value="XM_010699942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RN96"/>
    <dbReference type="GeneID" id="22574252"/>
    <dbReference type="KEGG" id="lpan:LPMP_200450"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200008200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_200450"/>
    <dbReference type="eggNOG" id="KOG1767">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10263513at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000678">
        <property type="entry name" value="Ribosomal protein S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004977">
        <property type="entry name" value="Ribosomal_eS25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12850">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03297">
        <property type="entry name" value="Ribosomal_S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN97537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="120" mass="13096" checksum="4E191012B608A8A7" modified="2014-11-26" version="1">MPPKAGQTKKAKMEAANKGAKKTTKKWSKGQSREALQNAVMFDKETYDKLRSEVPKYKLITPSIISDRLKIAVSIAAAGLKQLCREKLIRLVSCSSKTRVYTRIVQAASAEATTAAPAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNC0</accession>
    <name>A0A088RNC0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Flagellar attachment zone protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_200700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97562.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698269.1">
        <property type="nucleotide sequence ID" value="XM_010699967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNC0"/>
    <dbReference type="GeneID" id="22574277"/>
    <dbReference type="KEGG" id="lpan:LPMP_200700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200011300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_200700"/>
    <dbReference type="eggNOG" id="ENOG502QU7S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272636at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0966">Cell projection</keyword>
    <keyword evidence="1" id="KW-0969">Cilium</keyword>
    <keyword evidence="1" id="KW-0282">Flagellum</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97562.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="844" mass="93893" checksum="DC0C23F6111CA3E5" modified="2026-01-28" version="2">MLAAYVDPPAHQLRVGQVVVYDYLHAAKTWQWTLGTVREITDYTAIVQQWGPHTGDSDTLRSILLREVDTENGRMKSYQDMLALAREKLASIRRSNEDRVSRVRGHFDKAREELERIDEVDLRKVTAQAAPSPVAVAVLKAVWAVAKCDPTAVEFYEWADVQLEYRRRAALDEIAKMDVLAKLYPSAESLQQSLEHGPKLNYKAAARDSPVVASLHAWATTALAYQQAYSLLAHDKRIQEQNDAIAAAIAGMKACRAKIAKLKEELSSNGTTTLPEQVTSFTRTSVLVTIPLSAVISPVSVDSRMKECVLTKDVVKRIPVDAKITRYEQKQKLAITVSHFLDQYAAAISTRIYATELEERLFLIQHYLVSALRDAQADAVEQNQRLAASLQELEAFRQKRHDAKKARITEPELVDADSIEPNRRRTSSCAAPRGTPSQHPSRSEVAHQSIDPATIAKEPLYAVTIDEYKAKDTAGQRAAAEVDRMVDEVEYMTDEVQRLTAELEDAKVEAGRLAEELVAKDEELKAFRQKRHDAKKARASDPVLAAADAVAPCSVHAAYATPNSSRKGAAPPFVGAVPHQAFDPITMPVSPAVVAAEPLYMATAEELQHVRDVADQLAEQAVQGAAAREAEVYDAMSNLEGELDVARARIAQLEDVAVALKMQLSGAEEAGKKVTDALEVAEKERQQLCDDLEAALDELELKKEEYDQLLGNLEEVQVLLEASNVAERNALEALEQRNRNMVDLQGDLAHALVVSKENENLRAQLEAKEREINKLKEHNELWTDPVDTRTQKVTHRFTKIFEGDWCRLVRKRPEALKAAFLIDSSNACHVPGDQIGFVDFVHDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNS7</accession>
    <name>A0A088RNS7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_202270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698429.1">
        <property type="nucleotide sequence ID" value="XM_010700127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNS7"/>
    <dbReference type="GeneID" id="22574436"/>
    <dbReference type="KEGG" id="lpan:LPMP_202270"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200028100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_202270"/>
    <dbReference type="eggNOG" id="ENOG502SI08">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272171at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="315"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="496"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="624" mass="68985" checksum="716A4632BF565F1C" modified="2014-11-26" version="1">MELGGRMSSATDMVIAYRLPQDGADEEAYGLCLGKEGNTLRVIFLRIEKNYERLLKSVLRRRSEKDAVVKSLESRLQLLKSKVLEESDTTRPKSCRMQEIMLRLALRRLEGVEEEEWALLSQQRCPSAVISAVGCTVACIATGKSLVSSTWKDAQRLLCSGKGMMLQLRRVGEKRLERLLYDSISETYLSDSTLSYSSASQESPSLGLLHKWITAFMDYQRAHYMEDREPELQRQIAGSQSSLQSARERRDSLTKQADLISKGICYSRTQTVRSVPIEHVLYLMTAERVTNWQYLLKERISIELLEETLAKSFAGQRSPRGSCGEEQSRMTTFSSARAKDPVSGVSYPDRTSIAALTHPAPKTEAARTGTWANRGHVRQPRASIADGSYVESVKSRCATVLSSIDPLGERNDKASVAKEVKWASGGNSCVLLSSGKAAVTRGSTNMSTAIDAVTTSFSLITQVDRQNGVFFPSHAPCTPSASDDAQHVLADVKTHFKNVQETLLACFEEYKQLEEKYSNTVEQSQQLLQTLEERDNEIARLREDLGQATQKQLLVSGIIALQQQAQHGTLNGGQCNGHMNCSHDAPLHLGASSAFDAGTFARCVEYLLDDTLDFVRGVASAPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPA1</accession>
    <name>A0A088RPA1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_170360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697727.1">
        <property type="nucleotide sequence ID" value="XM_010699425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPA1"/>
    <dbReference type="GeneID" id="22573779"/>
    <dbReference type="KEGG" id="lpan:LPMP_170360"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170008900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_170360"/>
    <dbReference type="eggNOG" id="ENOG502SIN2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="907"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="179"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="347"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="528"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="222"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="363"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="551"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN97074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1059" mass="115301" checksum="A83D5A1C63FDE19F" modified="2014-11-26" version="1">MSFADAFRDAVGEISYTGDELIKALRAARAVLAWLPDDSHLEQEQRFERQSRRRLGKVIDILISESESSEDDSDSDDGRGTEWSRHTEAGEGTTGNTDAVSAVDEVAAPPSQFFTHAAQSSAAAAAQVAHHDRATQSIALALPEDPAAHLSASRGRLRNGSGFVSPVSLHSGHPLLRSEVASCDGSRTPAKAHERRQHRGESSEKRHGGLPDSWGDDDVHNASSASDTTTSLSSSSTDDDVEKRERVRQLELYDQDPSEWLRQLICLGAKLFGEQVEDYFHAVHTLIYYMAVRRKRVEQRSQYLRNRASRETAEGAAVQLADAASRAFSCASLSSCKVAAVASHEDGATTSANEGEVNAMESSNDDDEEEEDGEEVEGFYISREAKRSICVRLPDNAFRLRDSIHNFFFSCYASVVIQGSVSAAQVKQAAAEVVRICRGVLTWPRYPLNLREQWEVDRKEQLEQFLSKWRGEANGHLVTLMTAPPEAPTVMVRRARTQGEDGIGNLTATRSPPSTINLESIMADESSFLHDSSDDNEDGGSETALDPSSAKAPQQRQFLGPQTSDEEAITMATEFVRSLAPCSTRLARLVAGTVPGKGVDALLPCIEQPERRTFNDGFCRLAPYLSRKESDLITELMQLPLTEMPVVRGDDKGGHDQHALRAAEKAIVKHWASPTYDPRGGELTVLINPTNAFRLQLSNPIIFSLGGVQCDMCCVTERRVSFQAVLDSGVRSEVVLEYEGCIGYDVCVACSYYYYKSSEMRLLRAVHPNPHLRASFAFGRLSKVRVHSVHAFACTESEGDMTVEVVMGVSPYSVMPVGWVLPVDQLAELSAACPLLDEETELTTDVHASLPVPPHDWKRRCTVTNISNLFSGTGGCGDTAAAVAGASRQGVATGVAGNHLIDEADVCPICLQLLRSPLPVLRTLCGHSFHVECIGSHYHYKPTIVDGEVNENNGCPVCRCSEYMPPLTDADVMMRTNVYRLILRVPADEVAKGRDARAREWGGGCAVAVGTILTNDGVYHNASNIASCEAFYGVLPGFAFTRDATVGAKGMEATSPVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPB5</accession>
    <name>A0A088RPB5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_202980</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698500.1">
        <property type="nucleotide sequence ID" value="XM_010700198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPB5"/>
    <dbReference type="GeneID" id="22574508"/>
    <dbReference type="KEGG" id="lpan:LPMP_202980"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200035800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_202980"/>
    <dbReference type="eggNOG" id="KOG0804">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273556at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000555">
        <property type="entry name" value="Zinc finger (Ubiquitin-hydrolase) domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007:SF7">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="4">
        <location>
            <begin position="121"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="302"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="455"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="367"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="305"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="471"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN97793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="488" mass="52978" checksum="E3A2A8BD9579A130" modified="2014-11-26" version="1">MDHIPFCVAYAAACSFSGCAIVVLACLNMQDVLSVLQVCADMAAQGNGLRTSSMYVKGFPCLEGVPTTVDAQVLTSYYYIPTCPLCGDRLECTVSGYDSQTSMCACARSSSASQCTCFLGSSCHLCRRFADSLEHVQQQQRQQKLAASAAIKCEACAKAGDPWICLICGYVGCSRYQAMHAKDHCVAQQHFFSMNLLTQQIWDYDGDSFVHRVVILLDSDTGTSTWMQFPGRNEPILHDTATGESAAVGTAVSDTPETWKAEKKSISAKYDKKLTSSHAQYAMVIKSELDAKRALYESQLAQEAGDGDVDEDDLEKTELGNGAASASAEDVERGEYMELTNAFEPLNSVLMDVGEKRRKMTALLYAVKNLEHEQNTRDEETRRLEQQLESCKKALRSVIQQNVAMDLRLSSSIRELKEALQDIALNSDTQRRLAAQLGDQGVARVVLCGGSGSTVNAQSSAAPVGRGLSEKISSNNTKDVSGQGKNNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQH5</accession>
    <name>A0A088RQH5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_220790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699079.1">
        <property type="nucleotide sequence ID" value="XM_010700777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQH5"/>
    <dbReference type="GeneID" id="22575125"/>
    <dbReference type="KEGG" id="lpan:LPMP_220790"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000041300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_220790"/>
    <dbReference type="eggNOG" id="ENOG502SNBA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272277at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="122" mass="13131" checksum="324DCE85581CE1D8" modified="2014-11-26" version="1">MSSANKTSGGKWVSPRVLQYKQQQGPNTGPASGNGGVGSKIMEDKAIAAARIKDSQCSPAPEAEVAESKFFEVQEATDALSNLAHNAESSTYELCGKPVVKPHQTTEEFHKIIMEQVQKQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RR64</accession>
    <name>A0A088RR64_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_220920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699092.1">
        <property type="nucleotide sequence ID" value="XM_010700790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RR64"/>
    <dbReference type="GeneID" id="22575138"/>
    <dbReference type="KEGG" id="lpan:LPMP_220920"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220012600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_220920"/>
    <dbReference type="eggNOG" id="ENOG502SINZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267766at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="378" mass="40054" checksum="B9CB9CFD63D51591" modified="2014-11-26" version="1">MSTDMTTVWSHMSHAPHYYHAVDGLSSRYFCPPTPEYESYVNTGLLAPAYASETYLLGQHQQSPQQPGLVGGGCRTRVSPMYVSAPLLTATPITEGGLSVDAASAWNARDYAHPALKPQLQAQQLLFSNAEVPDYASSAHPLQHPLILESDLHALAYSCAESYASPVDAEPPSAVFSISNSSQNAPISQVNGTSSVLGGIPALPVPPSVAVFAGGTQEVFWRRACLRVTCVPVAGSSGRHGEVTAAASGDAQRAVRLEEIRDMACSSSCRSSHKGSDASGEGLDDLVWHWLDTLGMADAVEDVLSPGAGRVLVRWKADFTYAQDIREGDASDDGWRLSTAGGRLARLLGVRGDGEGSNSDLRGALCEVIVDGMRLLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RR68</accession>
    <name>A0A088RR68_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mitochondrial carrier protein-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_231530</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699309.1">
        <property type="nucleotide sequence ID" value="XM_010701007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RR68"/>
    <dbReference type="GeneID" id="22575358"/>
    <dbReference type="KEGG" id="lpan:LPMP_231530"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230023300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_231530"/>
    <dbReference type="eggNOG" id="KOG0768">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276989at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="184"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="299"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN98602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="400" mass="44482" checksum="2EBABC35A5EBEE6B" modified="2014-11-26" version="1">MLVHTEQPSLDGCVEGNGGISATTLPPAVTARHDIKPKSTMTDNAHGSRGSYHIDTLYADPEITVLASSVATTVTKSVLHPLDTLKCRVQLLRTDITPPTQPYQRYQCYPSQQPPGLLRTRLRQLRHQYTGQWTPGHLYGGLPVKLLFYVPYQATYVLSYNCMQHTLQGMDSEGKDAAGHRTANYVWHTVAAAVFAEVVSAGLRVPMETMKMRIQSATAHGSFDALRQLWQQGFASCARLAVPQVLMHDIPYSIIQWVTYETLRPWTQQWKARLEEQKGGTELAATSSASKSFWALYGVELARTLLSGGLSGLLASVLTAPLDNIRTRVVVATVRNRHLTVTDVVRDTYQREGMRGFVRGGGMRVLWVTTNMACYFPLFESVRSLLLWRENEGRLTGASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRV8</accession>
    <name>A0A088RRV8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beta galactofuranosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LPG1</name>
        <name evidence="6" type="ORF">LPMP_250020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699574.1">
        <property type="nucleotide sequence ID" value="XM_010701272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRV8"/>
    <dbReference type="GeneID" id="22575650"/>
    <dbReference type="KEGG" id="lpan:LPMP_250020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250005000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_250020"/>
    <dbReference type="eggNOG" id="ENOG502SNZ4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10267535at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43179:SF12">
        <property type="entry name" value="GALACTOFURANOSYLTRANSFERASE GLFT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43179">
        <property type="entry name" value="RHAMNOSYLTRANSFERASE WBBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="5">
        <location>
            <begin position="111"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN98867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="429" mass="50023" checksum="9A4C4064DB65A14D" modified="2014-11-26" version="1">MVANRCTVNRRWIKTRVRVNLSILLFLVCYVVPIILFYKRTRAESFVDASRQGETFISDNEFFQCVAARLSYREDHPMRIPYVLLPVTMDYQDIKQLFCNITIPMTYIMFINNGEFRPLRSLLDRLAQALSTHVDKNLFIIHHPENTGYASAVNEGLRHALTFSVAEVPWIFVTNADVRFAPGLITEFVSQTREKTSNQTERIRHLDEEVAAESTTLKNVPDARFAFRSSTLPIITASSLPYRIRTMPPEEMKKQFADTYGIFYMDCKEFMATFALPRLTIATVGFFDENYYPIYGEDHDYVWRMAALGYKPYFSKPGEFVHYVNANVQAGGAARQRGVFKNTAYITQSLKFGRMSKQVFRHHYRHIKWFPDSKVLGSSTGRTPLPFRGSIPLDMWVLDTERRRYIWEIGENLRCAREYKHYNASLLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RS05</accession>
    <name>A0A088RS05_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcription elongation factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_240200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98655.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699362.1">
        <property type="nucleotide sequence ID" value="XM_010701060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RS05"/>
    <dbReference type="GeneID" id="22575429"/>
    <dbReference type="KEGG" id="lpan:LPMP_240200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240007000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_240200"/>
    <dbReference type="eggNOG" id="KOG1105">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="44867at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13749">
        <property type="entry name" value="Zn-ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.30">
        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036575">
        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477:SF0">
        <property type="entry name" value="IP08861P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477">
        <property type="entry name" value="TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07500">
        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00510">
        <property type="entry name" value="TFS2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46942">
        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN98655.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="329" mass="36007" checksum="4AC9849AB0C2F25B" modified="2026-01-28" version="2">MSEFVQPPAPSEARPPSPPRLPDAPMDSASPSPVSQEIQNASASSVAKRPRVSEPITHFLTPSSLSGFSHSNSTVSPSTAALAAVESGGDLDADTESASPKQARVESVSTTPRSPYSNLPRKIPRKTPAVTPTSSVATPTLVTPPIASPASPPHISASSPSPTAKRATLHQRWVTLLHDALMKERQSQESEGVLELCMRIVEAIPGDTEQIKDTFQTLLFSIKDSKNGELRRKVVEGELLVERLVTMDDRELANPELRKQIEEKMEERSKDTNLSEIRKAMRTSNSTLFKCHVCGARDSSWEQRQTRSGDEPMTVIITCNKCSTQWRKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSI6</accession>
    <name>A0A088RSI6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_250800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699650.1">
        <property type="nucleotide sequence ID" value="XM_010701348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSI6"/>
    <dbReference type="GeneID" id="22575728"/>
    <dbReference type="KEGG" id="lpan:LPMP_250800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250014000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_250800"/>
    <dbReference type="eggNOG" id="ENOG502SJUM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265687at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="292"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="330" mass="35647" checksum="82F4D34CEF39B4E2" modified="2014-11-26" version="1">MGVASESLVSILCIEATYKTQQALNNALSVDAARNDGDNGVAVATEVLRKLPGTKLCVSPYTTIHSIRSFLQQQEAMASSSSSGRAGSDTRRQPNSKSLANAHFFAILRPPASSEDAKANETFLPLQNTSSLQDVLASALVLRCADDANVDVTEQTLPLVYMRECQYGLSAGDFLLCALCAGLCGCCIGLCASGVATATTGSRHRKEQKKQDYQQQQYPAQQYSAQQYPAQQYPAQQYYGNTLAPPPYQDNYQGNAPGGQPYSYGAPPQQHQGNYPTAQPEYYNYSGRPEYEQPQQAQNPPAQYYYSPPPGEQSGGKYQNSSNTGCAAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSI9</accession>
    <name>A0A088RSI9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Parkin co-regulated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_252290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699799.1">
        <property type="nucleotide sequence ID" value="XM_010701497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSI9"/>
    <dbReference type="GeneID" id="22575877"/>
    <dbReference type="KEGG" id="lpan:LPMP_252290"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250025000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_252290"/>
    <dbReference type="eggNOG" id="KOG3961">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019399">
        <property type="entry name" value="Parkin_co-regulated_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21207:SF2">
        <property type="entry name" value="PARKIN COREGULATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21207">
        <property type="entry name" value="PARKIN COREGULATED GENE PROTEIN PARK2 COREGULATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10274">
        <property type="entry name" value="ParcG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839048" description="Parkin co-regulated protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="406" mass="45423" checksum="2A1269B8484EB293" modified="2014-11-26" version="1">MRLQAFFLQLMLVLTLRGLLSYSHQTYRFLLLPTDFPIHLRESNNACTASIVNRLKEKRRRNRLLPLDRCPVLQRTLPLSFFPLFFLPPNGSPCVAMSSYNIQPIVKGTKRDHSVRKYNRAAGAGPFGAVSTSCGPKKSAQAQSAAAPAGEAAATNAVVTGVRFPYAGTKHGYGGASSSLRKGRPRDAPDAAFSERGCGKSAPPKAGAFKKRLIPPTEFRRSYDRGDLPIAICHGSRPTVDWKVEVEKLDYHHYLPIFFDGIRETEEPYMFLARQGCLDLLERGGPKILPTIPQLIIPIKTALNTRHPDIICATLRILQQLVVSNDLIGEALVPYYRQILPVLNLFKSIHKRRSRSDAMDYGQRNRDDVGDLVNETLQLLEQHGGEDAYINIKYMVPTYESCIYNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSL2</accession>
    <name>A0A088RSL2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein ARV</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_252500</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Regulates also the sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ARV1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699819.1">
        <property type="nucleotide sequence ID" value="XM_010701517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSL2"/>
    <dbReference type="GeneID" id="22575898"/>
    <dbReference type="KEGG" id="lpan:LPMP_252500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250027400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_252500"/>
    <dbReference type="eggNOG" id="ENOG502S2E5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2192830at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097036">
        <property type="term" value="P:regulation of plasma membrane sterol distribution"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007290">
        <property type="entry name" value="Arv1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467">
        <property type="entry name" value="ARV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467:SF0">
        <property type="entry name" value="PROTEIN ARV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04161">
        <property type="entry name" value="Arv1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="204"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN99112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="250" mass="29008" checksum="35A3307265295B62" modified="2014-11-26" version="1">MPVCIECGHGVPRIIKPETKTVELCGECGRICDTCCEFGDVQIWIDVVLLRRRAWAHVLFNQTDYYTKLIIFLLCCVVEAVVVQNLTVLEAITFFMGDLQNSSLYTPERQVRSLQLVRIIQSSFLPLMSYPSSIFRLFVFTFTENVLVASIATWLGRFFYPSYGHRERLWFMEAALASYAKLSYFLFLIWAIPPSMLPMVDFVYILWLGCAFTVLGFGHHWLYPVVTVLVCVFARGMFRYLTKWSPQLLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RST2</accession>
    <name>A0A088RST2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BolA-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_212170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BolA/IbaG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699001.1">
        <property type="nucleotide sequence ID" value="XM_010700699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RST2"/>
    <dbReference type="GeneID" id="22575039"/>
    <dbReference type="KEGG" id="lpan:LPMP_212170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210025400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_212170"/>
    <dbReference type="eggNOG" id="ENOG502SE3N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4983at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.90">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46230:SF7">
        <property type="entry name" value="BOLA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003113">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="79" mass="8581" checksum="B4F205402BC8BFE0" modified="2014-11-26" version="1">MSSVRDTIVTRIQEAFQPVELEVTEVSADEAKYSVSIVAAAFAGVSLIERHRKVNNLFAEELRSGTIHALSISAKPPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSW3</accession>
    <name>A0A088RSW3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tetratricopeptide repeat protein 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_252000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699770.1">
        <property type="nucleotide sequence ID" value="XM_010701468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSW3"/>
    <dbReference type="GeneID" id="22575848"/>
    <dbReference type="KEGG" id="lpan:LPMP_252000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250022100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_252000"/>
    <dbReference type="eggNOG" id="ENOG502RA4M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="626167at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051476">
        <property type="entry name" value="Bac_ResReg_Asp_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46630">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46630:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN99063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="482" mass="52952" checksum="36955A4887DAF8B6" modified="2014-11-26" version="1">MESAFSLVPRKPAAASGLEKPSSSGRWAKSKRLQSTNSSPKAALSGAVGRHGTPTDGVHGRSSLCLAQAGRTRREEITTGLRASQEGTADAAARPEKRNAAKTKAADDAKAFIVVVGSERDSVPFRLCCEALTEGCVQAYVHLFDLAHRDPVCVDTLSRKFFSVPDDRLAWVQQQLSAVEVLRRQSEFEHVLSHCQQLANYFEGEGDYAEAAWHYETALHQMRESLDHTLEQRAREAYATFQERQGHLGEAAVLYEAMYRLAVALRDEATLQAASRCLVRVHQALGDAVKFSNPAAAARHYTKAAEAAERIKNGLDEGAAYSALGDVSEARGDLPLALKYQRSYRTVAQQNDLKPQECHATLRVADLEERLGLKLEASTTLQEALQLAKELGAPRQLCIATMQLGEAYRIRDQEDQALQCFEESFAAAMEAGDQELIDTVRIAMGFARGDYYLTHAYGGEGYLHLVYTDIRAQLAWMSGGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSY2</accession>
    <name>A0A088RSY2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_220600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699061.1">
        <property type="nucleotide sequence ID" value="XM_010700759.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22575106"/>
    <dbReference type="KEGG" id="lpan:LPMP_220600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220011000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_220600"/>
    <dbReference type="eggNOG" id="ENOG502SE7S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266024at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="877"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1530"/>
            <end position="1564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1530"/>
            <end position="1541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1816" mass="188955" checksum="933DC156FF66515B" modified="2014-11-26" version="1">MPLISSTTSKESCGAVDSVHLIHSICALDDHTLVFAIASTACANSAAGGSFGAVRFSLREASDDAAKEKSYGPRPLSCDTSPTGVLRSALYARSLKASRRADFSSSSHEECNEYPECCRGADSAGGVGNSLTLPTIGSHSRQSCLSLERAAPAWAATVASLSERSRDSLAVLRALQVSSSLHLCGAASKEPPAGAPPTSFQPSPSHVSGGALVALHVVRQEAWQCSPDAASTTTQFTMAHNASSATLLSTDVLCYFDCGCAALATFKLTRRLPASEWSVQLSECAWIPSATSPRSAPSRGGGALKGGTFLSTYETGVPLVSSLVRPLPTTASLATCADDNHDGRNSLLELLVVWCSPTVASSSSGFSLLPCTRPVARYASLRCCSRAPATISTVEREWQLHSQAIFDMSELLNVAPSASLSSKGVHDCASLCNALPHSSVRSLSWLPGTAAFTQSYPLLAVLYAAPTVQACHVNSVGGAPTELCLDSLAVCYLKEDGHHLNAVTTPHKTLPMVTGRLLVGPWSVRGLSLAHPQFLFSTALAGLRSPLSQPPLAINARFAAGPVASAPPSAAQVFRATLHSSADEAAAVLGVFQRPVQEPYAPSSVFRSFATTISRRRHGGMAMAGTPLANGNMARLRELSQLQHAGAEPDNLSAPRNSKVFAFVLYGSEGEVARCVLDGYVEDAQTTWLAPRIMPAHKDGNSRATGDVLGRGDEGVSRSVAHVCALLSEKPLTLSAAKVHWHSAVVIAIQAQWTRAPPMVAERWHDNEPRSRSRSSAGDHWRFSVQVTQRLRSSGVPGGVLSRPWCATPLTMVGRILCWRSAAADCDTTSGDVSCLVCGYATIPHHGGTASSVVDASDNILLEGVFELWLSASVMSSSDDGSGRPATVTPATNATLGIEQRRGTETSSAAASLPQSTAGLCPWAVGSCTRVASPSAFSAVLHNASTTDTLATAFDLLSHTPTFLVSAARFGSTVSDGVVPVALAWVGGGVEADVDNLAQAAPSLSGAPTPSKASLLSCVRQLDAVALLRSGDVVGWRCTSSFSAAATAAGIPSGEGVVLHLGVIWRGLAHGTTQPLNELFCKLLLGSGTGADAVHMEVVTSPMEDKSRRVNHRQAGVGESAMEGRNSSSASLVAEMAAKGTVLLVLAVGSLVGVVDLAAEAVVFVRDLRADLPGISEREGDTIGRRAASPATADGATTLVTASVLRLQRLPVVTPCGWMAAGEVAQQGAGAAVGESWYFVWSGATEPQRGHSSLAFVLRLSFLRWVDVVSAHVGAASNSAAGGAAPTASVFDTEPSPAPLVTLQVDVCLQGETKPPGYSAAVSSVSPPPPSHHLSVSRFCSSATAYIGWLSCPTGCADDGVGCAAPRGTTANVEAAASSGDTAGYLPLLSVCDAALLRSLWPTMSTDEIQMSMSQNCASLLPGAVVPRHRPPLRLFRWGGVVLQPSIPSSLLLHHQIGAACLMEQLARGGATTRLGMPLHVVHRSLLGESHDANTTLTPPEKGRGVDLLCGLTCRQVLYVSTLTLDVRADGGRRDEHEPVPQERTVSRSPSPAVHGAQPACSSSDPTPWHVLLCTMLLNKGEQTSRSNESAETFSGTSASFDVGAASATAMRIDRGEGQAASYLLCGLPARVSAVPPQQKPSAAAVTHPSSLFTWHWIPLHIATSFPAPSDCGRGGMAPAGIVSTGSGGVEQHPAPLAITRVLPLPSPKRFSPAALPPTHAATVSAKSVPHAVAPGSYFYCEGMLSDPAVPGAPHGQQASYYLIVQGGRLRRLLERSAAASALTDDFEQVYMYTTVDPDLVRVVDTSLASHVRVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RT55</accession>
    <name>A0A088RT55_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_262100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700029.1">
        <property type="nucleotide sequence ID" value="XM_010701727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RT55"/>
    <dbReference type="GeneID" id="22576113"/>
    <dbReference type="KEGG" id="lpan:LPMP_262100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260025700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_262100"/>
    <dbReference type="eggNOG" id="ENOG502S1B5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268509at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="113" mass="13264" checksum="8DACED0D8A7ECC5F" modified="2014-11-26" version="1">MSRNTREFNKQADRFAEEYKEQRIALEQCLQSRINDDINFVCQRQKSAYLEGIAKLFCKKEYDAGVICQKKAGDKWASDCFKENVAFGQCTDRVLKQLYVYNLEHHKKNPSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTG3</accession>
    <name>A0A088RTG3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_261710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699990.1">
        <property type="nucleotide sequence ID" value="XM_010701688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTG3"/>
    <dbReference type="GeneID" id="22576074"/>
    <dbReference type="KEGG" id="lpan:LPMP_261710"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230028400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_261710"/>
    <dbReference type="eggNOG" id="ENOG502S93E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266468at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="474" mass="51954" checksum="15530AFABC8008FD" modified="2014-11-26" version="1">MLRPSRPLRRSIDGQRRESSSSQSSKGSMASQRISCRFHETSSSFATTSTASCVTAAPPGPAAVPDSEMTLAVPLPSLHSCRAGAYKVSGLRRVHSLPQGLTSSVSAADCMDNVASAVARSVKSNSDGHSGQPSSSLKVSTPHYACLQRGFDGTVRQSCVPKSGQRLFTSAELSMLRNEARQTYTHRRSMEEQKELVVAEAEARSLLAEVALDRIAAVWELHRTECEFRMRAASAAMLPVQCLEQRIRRRINEEDAQRDEQLRQEGRVAWRLQVELEKTAAADTGTREVERRAASHRFGAALTFITVQEIKLRKAVEAASAKFWGTFAQEVAEGKADAEHRALVRFLNTPEQLALAAAREQRERKRARRTARLLKLFEDQQKGFVNGCRHGTGGVSLFVGDTVKRVCGRCRVKWDEGLGYYVSIDRTVKTHPPPPPITAEADAEANTVSPVGKQPPAEVVKCGSVLPPVKKGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTH8</accession>
    <name>A0A088RTH8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutaredoxin-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_270800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700169.1">
        <property type="nucleotide sequence ID" value="XM_010701867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTH8"/>
    <dbReference type="GeneID" id="22576256"/>
    <dbReference type="KEGG" id="lpan:LPMP_270800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270014900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_270800"/>
    <dbReference type="eggNOG" id="KOG1752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015038">
        <property type="term" value="F:glutathione disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000384">
        <property type="entry name" value="Glutaredoxin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF18">
        <property type="entry name" value="GLUTAREDOXIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="3">
        <location>
            <begin position="14"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN99462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="96" mass="10679" checksum="5B4804DC622E1078" modified="2014-11-26" version="1">MSTTVAELIRQNKVVVFSFVHCPFCTRAKSILTSATKDVRVYECDQMANGEDLRHQILKAYKHETVPAIFINGEFVGGCSDLEAMQKSGDLAKRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTQ0</accession>
    <name>A0A088RTQ0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_270080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700095.1">
        <property type="nucleotide sequence ID" value="XM_010701793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTQ0"/>
    <dbReference type="GeneID" id="22576184"/>
    <dbReference type="KEGG" id="lpan:LPMP_270080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270006200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_270080"/>
    <dbReference type="eggNOG" id="ENOG502SFRV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="261501at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="349" mass="39075" checksum="F8E81A008AF0EF61" modified="2014-11-26" version="1">MLESPAIAENVVSLLLSMLLRKKQVPMPLKEVLLSTSQPVLAMRAFEHANRGVSPAAQATIHHSRKQKVSQPDSPRAVDLLADVPGFNRPFEVAPAGTQFVILTAGRSPTPPVSENTVCLPFSLLDIAQFHRARHRERLPSLAVSSSRVTPIALLEGAQRESTMRSSFELYCRPASKDLMVVDIPADVTVDAYLWEALLAAETMLEADGVLLVMSPHTFSTRVRNFLQWRFCRTQYGVSEVCAAHYAVCSAVATDFGDAAVRRDDFPRRLAVGKRRPRKWNPYRRSEERKFVMSLQPGFTNAPLTQSALRCNVERERDAQERLRDADEAFFAVAHEMVEKSAHYSYPND</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTS9</accession>
    <name>A0A088RTS9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SUMO1/Ulp2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_262030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99315.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700022.1">
        <property type="nucleotide sequence ID" value="XM_010701720.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22576106"/>
    <dbReference type="KEGG" id="lpan:LPMP_262030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260025000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_262030"/>
    <dbReference type="eggNOG" id="KOG0778">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1939479at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019784">
        <property type="term" value="F:deNEDDylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044613">
        <property type="entry name" value="Nep1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46468">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46468:SF1">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN99315.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1354" mass="146523" checksum="0291176F4E65C9F5" modified="2026-01-28" version="2">MISQPSTRHHRSAEEASHKFSSLFFAETTNTAMERRPAPQGPVGDGLPSFKASLSSSTSLATADIQTHATAAQPDSVPSRSNTVWKPTRSPTIRPPPSAALPGHLLRRHSHLLSPSSEGMAASRSADAGRLQASAAASLESAQESGETTTHSSTPPPYALVMDSLVRRYRAEEDRLRQWRQGGGRAPIAAALRHSGVQSQSRKGDAIEEEGITHVGLRGSMGGVSSGHRSRGADGGLRGKFTRSVQRTALARAVQAWWRSRRALQRMKSKASRRLYPTTLSVSSAAVSGAETQHLRHMATALVSSAPAAPPGLSLSWIGRAGHSILGCISHSLSLSSDRGQSTRLELLRRADAAQLRGAHRGDYGNPVYDSLVEDQQPSGTERAEMTAETVSTGVVAPVMPLSRTEGETVLAHPRRRVLQQTAAGARSGALHRQLAVSGRLIDGEADLRISSVSSTCSSRGSNVSGEGREAIQSIEAVDDLSHRQEAGSVGWHEDKGSFILSWIHASRMHFSDSGEAASSGDADSSFRNVSRLFAQSRMRFARWLHRQKRLKAAKCSLRGVRTWSKPTAADAEHRDAFLGARYSSATPTPFSAASELHRCAAQAAPSPWESALPQTWGDWDDSDEVLRDGEVTDGATAAAKRPTRAHILEKRRAAIAAGTAASNAAQEGLVERETMSEVQSSVDEAPVLSLAAQRTRQHADDLSRLTESLAMLTLLRERSPAGAGNGIHAHRANSPQGVDRAPPMMVGQEQNAVAVPSHPSVTKVANSALPTWSPSRAYASSIISAGQHRRSYHGSAREAHGTESRTCDGWCCKHAVEKEAGVDAFHSLLTDTTHTQHDLAVRAVYESIMSEVCTCLVQRDVENAIDVTCSAADRALTQWIERQLMLELTQPRSRERQRTAEDRDSAAYSATTLQPLVCTGVTQHIRSGVPVSLEHLHLDDVDRQALASVYARGSSNAIAVKFDTEGYEISYRQLASLSPQSWLNDQVVNNYLQLLCLEAEGAATASFSAAQCRHRIASLGTHFYTKVESEFRQRLGGFSGLPPRLPQLDSSSAIFRWLRNRKHLLEPYTSSDPRSVRVVLVPVNIEGQHWALAVFHCADNRWVMYDSMSRSERARQRGAVILAHLSHAWCECQRHFGFIRTEDTTAATATTDARYSPSSGVLQPSPWASACVVAAPYVPFTDALVMEGHSTVVSPLDSLQPYGSLDHLHRAAKRMRHQEELFAEQAGQRKLQRASDSGGGAWGAGVIRSASAATVSLPPPLSKTAATTLPAEQLSDREVEWFTGGFDHIPQQANSNDCGVFVCQVAWCVAQGVAVSFTQSDVTRLREVILLELLNKKLLRRYPTANTSSSAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTY2</accession>
    <name>A0A088RTY2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_240450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699386.1">
        <property type="nucleotide sequence ID" value="XM_010701084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTY2"/>
    <dbReference type="GeneID" id="22575454"/>
    <dbReference type="KEGG" id="lpan:LPMP_240450"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240010400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_240450"/>
    <dbReference type="eggNOG" id="KOG0379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266141at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="179"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="885"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="966"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1044"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="888"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="898"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="966"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1058"/>
            <end position="1070"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN98679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1215" mass="128201" checksum="4836EE4560A8E124" modified="2014-11-26" version="1">MNIHIERTSSIAAASTGTLSAPPSMIWAAGSSALARQNSRSSGCSMANDQRILFFPSSKETSYKQLGRIIHTSGTGTKETVTATSELTFASAHCKMGVTQGCRKCISDECNEQKRQYFLQQQCPQRLSWARIGGNALPEMASFEVATTNSLRVSNSVLNVISASSENWEDHRDLSISSGLRGGGRRASGGDSTASERDASLSSSGSGVDVGREVALQPPARFGHTAVLYKNSQILIFGGKASEEHYFNDVYQYDASARRWRCLQEECIDEATAAVVANEQGSVSPSYASAQSASPSFSPTASPPASARWVEAVLMAAPISDATPTDASSPRYSSGSINNSSIQERSVIQRYAATSRVFAGPVHQGTLAGGTLAVSASSSRDGATRYYNSLLETEVTRRRRPAGRVGHAAALYQDSMYILSGEYLGHFFDDMWALDIPSLTWYKECGLPFSPRKGHTMHLLPADFTATRARQDMLVVFGGLVKASRARPRPADPELPTRSQGEPDFACAPTNAVLLYYLAQRRWCQLKTCGEQPSARFYHVSQLITGTALLIVFGGRSTTPAQTSDGTAAATEGAFLNDLHILDVSTGFWRHIRDFTGDIPSPRMCAASVFVNDTFGVFAGGGDTYCEDAFEFSLQSRRWRRVKLNNQPACSRPTVTYTKDRLVFFGGFAPRTGVMSCTMELCLSPLSLRSQGLQWWSRCTFEKHIRSCTKSRALEMEEKAAAAAAAGTMERSGSSWFTGCSGQVMLQCSPSVTARSSPLATPRSWFVNGGVLRPAPLRVPSFDQIGVLSAAAPAWGGGPPATRSPARGALTLSPTLSCWSSSSAVFSPLSGSSKLIPSWQDTASSNSNLAGGGTVYASGGGGTTATFCSLASVTPPVHNLFPSHPVTAINSSRSPSQTGSPATVSTAASTSQAHLWSHMTATVVQNTSAAGTAVYSGSAQAHSRSSGALAAEDANVMVVGVADCTQSRSASSPPTPLSHSAASSVLGSAPSVSHTAGLGRSSLPPPVTATGEQPASACFITNCVRNLSGYVAASVPHLARSFSNQAPPSAHTGGPPLAAAAVNNGRRGGNSAVSGGNWGYPMCMQQRGSPLQGRAVRLDVALFGLSPSPQPTHDPSAGIVACRQPSPFVQRSSSITNGGGSAFTTPQQPHVSTQFTESASSSISSGSTILAAHIPSMYAKYTIQRLEGTSGPYFLQALAARLKRHEAEHTEKRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUI0</accession>
    <name>A0A088RUI0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">oligopeptidase A</fullName>
            <ecNumber evidence="8">3.4.24.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_272600</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Hydrolysis of oligopeptides, with broad specificity. Gly or Ala commonly occur as P1 or P1' residues, but more distant residues are also important, as is shown by the fact that Z-Gly-Pro-Gly-|-Gly-Pro-Ala is cleaved, but not Z-(Gly)(5).</text>
            <dbReference type="EC" id="3.4.24.70"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.70" evidence="8"/>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99638.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700345.1">
        <property type="nucleotide sequence ID" value="XM_010702043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUI0"/>
    <dbReference type="GeneID" id="22576437"/>
    <dbReference type="KEGG" id="lpan:LPMP_272600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270034000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_272600"/>
    <dbReference type="eggNOG" id="KOG2089">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270400at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000009">
        <property type="entry name" value="Oligopeptidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43660">
        <property type="entry name" value="DIPEPTIDYL CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43660:SF1">
        <property type="entry name" value="DIPEPTIDYL CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 9" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN99638.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="678" mass="76603" checksum="C3A41C21BC29BC64" modified="2026-01-28" version="2">MSVNPLLQQSRLPYQYPPFDRVKVEHYAPAFEQGMAEQMAEIEAIKANPDTPTFENTVVALEKSGALLTRAHMLFLNLCAAHVSPEMQKLEQAYAPKFSAHTDRVYLDSALYSRIRAVYDERACLADEDLRLVEHHEKEFRKAGAGLDDAVKEELKQVNERLATLESDFAKRLMDTRRTASLIVADAAELEGLSEDEIATAQKEAESLGHPGKHALVIVNTTQQPLLASLRNRETRRRLLEASEQRAGRGDENDTTAITVEIAQLRLRKAKLLGKKSFAEWQLQNQMADPASAEALLRDMGKAAASKATKEAADIQQMIREEGGDFELAPWDWRYYAERVRRQLYDLDENETKSYFELNNVLERGVFYAAEKLYGVTMQRRTDLPVYHPDVMTFEMFDYTGESLAIFGLDPYARAGKRGGAWMTFFVRQASLLGQKPVVYNVLNIVKPAEGRPALLTRDNVTTLFHEFGHGLHGMLSNLKYSTLSGTSVARDFLEFPSQINEHWAMYDAVLKNYALHYETKEPIPQSLVDRMKAAETYGAGFHTIEVVKAAYLDFHWHRVTEEAAVLPPAQMEEAAMRAFGVGMTEVPPRYHSGYFLHIFAGGYASNYYVYQWARVLDCDGFEWFLESGGLTRENGDHLRACVLSVGNSVDANVAYEKFAGRKANMKAFLRINGLLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUM4</accession>
    <name>A0A088RUM4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cullin-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_282240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700564.1">
        <property type="nucleotide sequence ID" value="XM_010702262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUM4"/>
    <dbReference type="GeneID" id="22576669"/>
    <dbReference type="KEGG" id="lpan:LPMP_282240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280028700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_282240"/>
    <dbReference type="eggNOG" id="KOG2285">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cullin family profile" evidence="4">
        <location>
            <begin position="409"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN99857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="768" mass="87428" checksum="2DB1A64072C73F47" modified="2014-11-26" version="1">MSMDEPESRIQSSFPPLWKEVAGICNTAFQKFKKRPSHNLCKDYNKLISQICEAHGLVYNLTAYQCSNYPALVRGSNSTPVVGETVESTQVLVVYYLLRELLKKQVNNVKATIQKDSILSYLDAYEKYTAGGNVVKSIFTYLHWTWQKRGLPAEHIIQPTEIVVGHLWMDVILTTELKEAFRAKVNEIVCRVRSGGRTSVGEMESVKRFSLNLGCSTDVRLTLYSSVVEETYLKSLTSYYCAKRLVFKALGVVEYINQCVKAVKKEDVLARCFLIRSSYEQVSESVLRILIHDEKNYLSPFCKECIDPSDGSDPLSRKKSLSALYDLLGGGAEESWMEDLLRETVSEYADRELKKTHDSCEASSILRILKKAQQTFEATISGIFGHQPRLIRAIYDGIQANLAALERPTATEDNAVKIAKRLAKYAAEESKSMPVEELRLKSNWIAVIYRLCSRQDVFHQSYTRFLQERLLKNIFGTGKQSEIAVREESILSSLLIKDRNFAFIFNCMRMLNDTYRNDLKQAKRVQQFLVKPYILTAFPWGESRRSPDADRTSVPLELQTVISHDIDAYATLQNGRRLLFSPEHSGARVKMSIPNKSVSLSVLVSFLQMRYLLVMNKMSVWSADVLCSRTCTSLEECKRALIPFVQTGLLQEAVQHVFDLNPNIFALQNGEEKTYDLRYIELGSQQSNPEKNSFFLRGEKSHVLSIEGAVMRVLKELGPLSLDDTIGKVSASLGKLSVQRRDIKKVLEKLVEREYVERSEDNYLSFIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVA5</accession>
    <name>A0A088RVA5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_282220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0220 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700562.1">
        <property type="nucleotide sequence ID" value="XM_010702260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVA5"/>
    <dbReference type="GeneID" id="22576667"/>
    <dbReference type="KEGG" id="lpan:LPMP_282220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280028500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_282220"/>
    <dbReference type="eggNOG" id="ENOG502SB6T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268928at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007919">
        <property type="entry name" value="UPF0220"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13180">
        <property type="entry name" value="SMALL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05255">
        <property type="entry name" value="UPF0220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN99855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="142" mass="15846" checksum="7CEB677D08BE1A85" modified="2014-11-26" version="1">MSRRRSTIIVASGAIFMSALLVFVDGAVMASRVEIPYSFLMWLPTLCALLGSFVLLLVKPMYIVGTDTDMDDDDDVIKKDKSMFFLGAFLLFTSIFLSVWKAVDPYGNKGVAWPGVALLVHSVLLLLMNCALFIARMQYDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVE2</accession>
    <name>A0A088RVE2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar proton pump subunit B</fullName>
            <shortName evidence="5">V-ATPase subunit B</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Vacuolar proton pump subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_282570</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700597.1">
        <property type="nucleotide sequence ID" value="XM_010702295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVE2"/>
    <dbReference type="GeneID" id="22576702"/>
    <dbReference type="KEGG" id="lpan:LPMP_282570"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280032200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_282570"/>
    <dbReference type="eggNOG" id="KOG1351">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="585369at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18112">
        <property type="entry name" value="ATP-synt_V_A-type_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18118">
        <property type="entry name" value="ATP-synt_V_A-type_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01135">
        <property type="entry name" value="V_A-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12240:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit B, brain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00310">
        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005723">
        <property type="entry name" value="ATPase_V1-cplx_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003235">
        <property type="entry name" value="PRK04196.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01040">
        <property type="entry name" value="V-ATPase_V1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389:SF4">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039114">
        <property type="entry name" value="V-ATPsynth_beta/V-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="7">
        <location>
            <begin position="40"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="6">
        <location>
            <begin position="162"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="8">
        <location>
            <begin position="389"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN99890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="495" mass="55500" checksum="DA3451FA6C53D40C" modified="2014-11-26" version="1">MGHEEERVRVLSKQELLAAHIKELNESYSVKPHLEYTTIRAVSGPLVILEDVREPTFAEIVNIELADGSARRGQVLEVDGTKAVVQVFEGTSGIDVIRSKCEFTGRVMELGVSEDMLGRIFNGSGIPIDNGPPVLPEQYLDVEGIPINPRARVYPEEMIQTGISSIDVMTSISRGQKIPLFSGAGLPHNEIAAQIVRQSGLVKREGKTEDFCVVFAAMGVNQETARFFRTEFEQNGSMEKTVLFLNLANDPTIERIITPRLALTTAEYLAYDCGKHVLVILTDMSSYADALREVSAAREEVPGRRGFPGYMYTDLAHIYERAGRVLGRAGSITQIPILSMPNDDITHPIPDLTGYITEGQIYVDRQLHNRQLYPPINILPSLSRLMKNAIGEGMTRKDHGGVSNQMYAAYAISRDILAMKAVVGEEALSCEDLLYLEFLDKFEHKFICQGFYETRDIFQSLDLCWDLLRTFPKSMLNKIDIKTRDEFYDRHSGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVH2</accession>
    <name>A0A088RVH2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_282880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700627.1">
        <property type="nucleotide sequence ID" value="XM_010702325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVH2"/>
    <dbReference type="GeneID" id="22576733"/>
    <dbReference type="KEGG" id="lpan:LPMP_282880"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280035400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_282880"/>
    <dbReference type="eggNOG" id="ENOG502SF1G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272399at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="122" mass="12990" checksum="0553C8FBD82913DB" modified="2014-11-26" version="1">MNTTTEKVTISFNTSRFGVKVADGSFDPDTTIGEVHARLRKKLVKAKAMTVPVTSGGLEGVTAISSSTPTSGSGATFIFVRNGTEAFIPAPEQTLQTLLDMYATTPEARKLYITIDPEVFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVM7</accession>
    <name>A0A088RVM7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_291230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700731.1">
        <property type="nucleotide sequence ID" value="XM_010702429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVM7"/>
    <dbReference type="GeneID" id="22576887"/>
    <dbReference type="KEGG" id="lpan:LPMP_291230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290016500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_291230"/>
    <dbReference type="eggNOG" id="ENOG502SCS8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266518at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21389:SF0">
        <property type="entry name" value="ETOPOSIDE-INDUCED PROTEIN 2.4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21389">
        <property type="entry name" value="P53 INDUCED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="522"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="567"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="256"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO00074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="596" mass="64699" checksum="256A996E9501EA79" modified="2014-11-26" version="1">MPPSMVASQVRQEVHNFCQGVIESFGVVLVWSSALDKRRARDVAEVTEEQRRLSPPPPPFASFADIAEKEAAEGALPTALAPGFPVPLLRTALLSGSGPDAPRLARTFLMPSWSLLERDPKLWMLLRKNLLANLALAFLTLMYMGLSHCLASKTSLSTRSSAVSGAGATVASLSADTHSNNDTYATRSLTTTLIFLLFLWWVRLSLWMLKYVGQWPFYTLLQIIGLVWFNQLYRETWLVRKGWVLRGTELREAPAAGSAKTKAMEGGGGSGASATFPHPPPTSPPPSAAASAALPWLSLIPLYPSADSGGSGEDGIQYEARGPSSSLLLMCVTLLRSVLPYVRHTTNLVWRMVTHKGPTAVLQDWVLGDASKAAAAAAAAASTLTGARHPHAPGTAAASLHQSQTISTSPDPFATVVLQLEVISEVLFKALATMSFALFSSAIERLPLIGTPLCAVLNAQLYVFYVFDYRYAAQQQPDAVHHRGSALTYQLRHFEQCSMYYAGYGMSSAVLSLWLTRQLGTVVSVCAVSVLYSWQVVWSGFAVPLPSSRPVPLFSVWFYAVDMAQRHYAVLWRMVVIAVLLYLPFDCACCLLGTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVV0</accession>
    <name>A0A088RVV0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Proteasome alpha 7 subunit, putative</fullName>
            <ecNumber evidence="9">3.4.25.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_270190</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="9"/>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700106.1">
        <property type="nucleotide sequence ID" value="XM_010701804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVV0"/>
    <dbReference type="GeneID" id="22576195"/>
    <dbReference type="KEGG" id="lpan:LPMP_270190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270007400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_270190"/>
    <dbReference type="eggNOG" id="KOG0184">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03751">
        <property type="entry name" value="proteasome_alpha_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000007">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 7 9" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="8">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN99399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="238" mass="25503" checksum="88439DA98ABBB11C" modified="2014-11-26" version="1">MAGTGSGHDQSTDVFSAEGRVFQVEYAGKAVDNSSTAVAACCKDGVVVAVEKIHSSRMLESGSNNRIHAVDRQAGICICGLLPDGRAIVSRARLEAENSRDIFSTPIHGAVLANRVGEFMHAYTTHFAYRPFGCSAIIASYADDGPQLFVSDPSGTVAGYYGIALGKAKTVAKSELEKLNFASLTCEEAVGKLANILHEVHDKQKDKLYEVEAAWVCDKSDRKFTHVPVDMIPPPPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVW3</accession>
    <name>A0A088RVW3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MP44, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_270330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700121.1">
        <property type="nucleotide sequence ID" value="XM_010701819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVW3"/>
    <dbReference type="GeneID" id="22576209"/>
    <dbReference type="KEGG" id="lpan:LPMP_270330"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270008800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_270330"/>
    <dbReference type="eggNOG" id="ENOG502RXAP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="278615at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23725">
        <property type="entry name" value="RNaseIII_KREPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="429" mass="48304" checksum="57E1A32B950989B1" modified="2014-11-26" version="1">MKPTSHCLRRFAAGPLILSHFICRGPALSFSAHAASSQTSVEPRTGGSSFARHAARVTTPRTTLSLDVNLRRTLRSLLIERLCSPTQPLPAKRVYDELTNRSRLVEEFHFSKTSRRITRQRLALQFLRRYNVLLHGLLFYSESTHTWNTTTEFHRLAILGESVILTEVRTRLLKLFPAMPYAAYVQSLLHMVSEEALAAAFDRYEMQNIVGVRPPNRRSGTPLTRMQKSHMLCAVVAEMYWFTARTKPTDLTHNNALFPPSDVLILHVLSTHLLENVPAELIYNVVEPIVADIKRVWVNEPMSLPSQLRLTPRTVSSLSLNAIPVAPLSITEAEAVKLLQKKHKDAHRQQHTLTREPDNSCVKSFMRPSFNYRIFDGPRYQVLNSDNRVAPLPLAQERSSLPASAVCIVSDVADSAARAMELAKMAESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWI6</accession>
    <name>A0A088RWI6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_301630</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701189.1">
        <property type="nucleotide sequence ID" value="XM_010702887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWI6"/>
    <dbReference type="GeneID" id="22577216"/>
    <dbReference type="KEGG" id="lpan:LPMP_301630"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300020600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_301630"/>
    <dbReference type="eggNOG" id="KOG3318">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="369569at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009445">
        <property type="entry name" value="TMEM85/Emc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19315">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06417">
        <property type="entry name" value="EMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIO00389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="149" mass="16847" checksum="CE145279F7316400" modified="2014-11-26" version="1">MASQVTNASAAGKQATDEEITRYRVMARLSDIRTQPLKQLPMTAFMMWMVGNEVSIFSIMFVGMAVVNPLQSIFGVGKMFADFEEDAKTDRQIRSAVNQARWIFIGCCLIAFFVALVKLNWMELLPVSSMDWMDNTPPTYQEFSSGAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWJ1</accession>
    <name>A0A088RWJ1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_301690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701194.1">
        <property type="nucleotide sequence ID" value="XM_010702892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWJ1"/>
    <dbReference type="GeneID" id="22577222"/>
    <dbReference type="KEGG" id="lpan:LPMP_301690"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300021100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_301690"/>
    <dbReference type="eggNOG" id="ENOG502S8CD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="253124at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO00394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="123" mass="13763" checksum="5299000EF322FA27" modified="2014-11-26" version="1">MQGFNGVSAYEAVEVMVVDRGTQTVSTVGTQTDPLPMPYGAYYPGPFAPSPYTGIGPYIRWMPPSLPLPRYSIGVDDQPFRHHHHDYEQREAAEAAKLRGELEMVQNTIDMLITRYNLPPPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWW8</accession>
    <name>A0A088RWW8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">KRR1 small subunit processome component</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">KRR-R motif-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_302970</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the KRR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701319.1">
        <property type="nucleotide sequence ID" value="XM_010703017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWW8"/>
    <dbReference type="GeneID" id="22577350"/>
    <dbReference type="KEGG" id="lpan:LPMP_302970"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300034400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_302970"/>
    <dbReference type="eggNOG" id="KOG2874">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="441223at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22393">
        <property type="entry name" value="KH-I_KRR1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22394">
        <property type="entry name" value="KH-I_KRR1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000014">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000090">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041174">
        <property type="entry name" value="KRR1-like_KH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048550">
        <property type="entry name" value="KRR1-like_KH1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048548">
        <property type="entry name" value="KRR1-like_KH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048549">
        <property type="entry name" value="KRR1-like_KH2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024166">
        <property type="entry name" value="rRNA_assembly_KRR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581">
        <property type="entry name" value="HIV-1 REV BINDING PROTEIN 2, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581:SF0">
        <property type="entry name" value="KRR1 SMALL SUBUNIT PROCESSOME COMPONENT HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17903">
        <property type="entry name" value="KH_KRR1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21800">
        <property type="entry name" value="KH_KRR1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006515">
        <property type="entry name" value="KRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="KRR1 small subunit processome component first KH" evidence="10">
        <location>
            <begin position="32"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="KRR1 small subunit processome component second KH" evidence="11">
        <location>
            <begin position="113"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="276"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="234"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="292"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIO00519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="322" mass="36071" checksum="13B72DCA89192AF6" modified="2014-11-26" version="1">MASTVNNNSKFVVPALKPEDVPGGACCVDETTFATLFPSYLESYIKSIWPAVEELLEQHQLVGRLDLMEGSMAVATTRRTWDPYAIVDARDFIKLLARNVPLAQAQKIFQADITCDIINIGVKGGSVRRFVKRRDRLIGPKAQTLKALEILTGCYVLVQGKTVAVMGPVKGTQMVRSIVEDCMNNIHPIYGLKQLLIKRELSKREDMKHEDWSRFIPVYKKTQPNKEKQKAVRKMKKERMKDLKHKQAGKVKTIFPPAPPKRLEDIAMESGQAFLAPRQRRPKEELELQGAASVSPSASANTRNKGSSRSKTDATISNKVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RX57</accession>
    <name>A0A088RX57_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_311280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701518.1">
        <property type="nucleotide sequence ID" value="XM_010703216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RX57"/>
    <dbReference type="GeneID" id="22577554"/>
    <dbReference type="KEGG" id="lpan:LPMP_311280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310014600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_311280"/>
    <dbReference type="eggNOG" id="ENOG502S7J9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267120at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="100"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="338" mass="37136" checksum="9B3AAA50781E502F" modified="2014-11-26" version="1">MLGSLDVTTGDALRSFHDALDQAQQSLQRDEKRLSATVQLLSDLTLEVDHLKAERAPSSATCQRREALQAEKVKALQHTRHQREAIAATADHIQHLQAPRLKLTKRVDALKIDVKVLRRQYGLRAAQVHAFIAQFLQPQNSLENLRCQLAQLQQERATQAEAVKMAQRRLEEQKADLAALEAADRLGTTSDSNGGAIAGNGKAPRTKSGDEAAAVLTLATDGNDVQLDAADEECAVDVPLFTEAERRAEATRRRSAQVAAHKSAETQQVEERTRLEALRVDLKRQVLLLCQEIEEADAAQQQEQKAYHDVLNGAVGEADGGVLRQCKRCSCDLFGGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RX75</accession>
    <name>A0A088RX75_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_303240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701346.1">
        <property type="nucleotide sequence ID" value="XM_010703044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RX75"/>
    <dbReference type="GeneID" id="22577377"/>
    <dbReference type="KEGG" id="lpan:LPMP_303240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300037300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_303240"/>
    <dbReference type="eggNOG" id="ENOG502S6GC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271947at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="165" mass="18674" checksum="D67291E6D7703797" modified="2014-11-26" version="1">MKSVKERDVAGMAAFELALQYSFIRQDRSYHFVQLLTALCSFVFFSQLTALNVLLVLPPLVPSVEPHVEFLRAYSHPLLAVLSLVALLLIRASKKRFVIEPGEQTMERLNRDILEPCLGMKFDTRTGMLFSDFRAGSLRGRENYYSLRYLDDPQPPLTSVTGMGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXP9</accession>
    <name>A0A088RXP9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras-related rab-4, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_320560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO00943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701743.1">
        <property type="nucleotide sequence ID" value="XM_010703441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXP9"/>
    <dbReference type="GeneID" id="22577797"/>
    <dbReference type="KEGG" id="lpan:LPMP_320560"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320010400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_320560"/>
    <dbReference type="eggNOG" id="KOG0086">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001072">
        <property type="entry name" value="Rab family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO00943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="203" mass="22228" checksum="200CDFA1EC414EB9" modified="2014-11-26" version="1">MADKYQQLMKLIVIGDSGVGKSCLLHRFIEDIFSEEQTQTIGIEYGAKIIDLGGVKVKLQIWDTAGQERYKSVTRSYYRGATGCLIVYDVMNRSSYESVPQWLSDVRQLAGSDVVVMLIGNKIDVAKGNSLRAVQHNEASLYAQQNGLLHFETSAATGEFVTEAFLRVAKSAVSLAIAAEPANDVQLSQDNKTNSSYLSSCSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXZ0</accession>
    <name>A0A088RXZ0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">3'-nucleotidase/nuclease, putative</fullName>
            <ecNumber evidence="10">3.1.30.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_312140</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclease type I family.</text>
    </comment>
    <dbReference type="EC" id="3.1.30.1" evidence="10"/>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701601.1">
        <property type="nucleotide sequence ID" value="XM_010703299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXZ0"/>
    <dbReference type="GeneID" id="22577640"/>
    <dbReference type="KEGG" id="lpan:LPMP_312140"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310028300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_312140"/>
    <dbReference type="eggNOG" id="ENOG502RYME">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="441446at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11010">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.575.10:FF:000003">
        <property type="entry name" value="Single strand-specific nuclease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.575.10">
        <property type="entry name" value="P1 Nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008947">
        <property type="entry name" value="PLipase_C/P1_nuclease_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003154">
        <property type="entry name" value="S1/P1nuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146">
        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146:SF10">
        <property type="entry name" value="STRAND-SPECIFIC NUCLEASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02265">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48537">
        <property type="entry name" value="Phospholipase C/P1 nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839118" evidence="9">
        <location>
            <begin position="28"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIO00801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="379" mass="41476" checksum="4EEA6C45A61DB6F2" modified="2014-11-26" version="1">MAQRAPRLPMALLALAVLCIAALPVSAWWSKGHMAVALIAERHMEASLVEKGNLAAKVLSLSGPYPQSPDMVQAAPWADDLKKVGFSAWSTWHFITTPYYPDPSFTLDVSPVQTVNVASVIPMLEMALQRATSNSDIIVHSLALLIHFMGDIHQPLHNANIFSNEYPEGDLGGNKQHVIIDSKGTKMALHAYWDSLAEGHAGEDMPRPLSKDDYASLNEFADYLEATYADTLTDADKNLVRATEISNETYNLALKYAYPGAEDGATLSDDYKKNAKQISERQVLLAGYRLAKVLNTTLKPVSAEIILRGLQNIQSEVDTENNATVRHYYVQKGTSAGVTAVIAVVLFIAGFVIATLVIFAFKSCVQKHKRFGPYGPISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RY76</accession>
    <name>A0A088RY76_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytidyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_322190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701903.1">
        <property type="nucleotide sequence ID" value="XM_010703601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RY76"/>
    <dbReference type="GeneID" id="22577960"/>
    <dbReference type="KEGG" id="lpan:LPMP_322190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320027500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_322190"/>
    <dbReference type="eggNOG" id="KOG3351">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="330671at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="2">
        <location>
            <begin position="183"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="327" mass="35654" checksum="F7789552C9F57464" modified="2014-11-26" version="1">MTPSVLLSTSCEKDVNAKSLVAYLIRSVLTPIATKAAKATDSASAASELARYCCPHTELHCGHGRSVDVYLAIHNRHRSTFLEHSVYLYSAVLEVCPQLSISIIPVIGTAKKEEMHVSGTSSSPALSQQHQQQRQFSGLQRSAGDSIELYADVAAVLQEWKLLDKSFMRDAEGFQPHYTYVAVGGTFDHFHSGHKVLLSTAALYTMQKLRVGVTDASLLTKKRFAESLQSMEVRMEHVTQFLHHMRPDLELELAPISEVSGGTKSIPEVEALVVSPETANSIGVINEMRAANGGLAPMVGISIPQVRSPTGELISSTALRECQIRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZ55</accession>
    <name>A0A088RZ55_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mitogen activated protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MPK11</name>
        <name evidence="9" type="ORF">LPMP_331460</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702238.1">
        <property type="nucleotide sequence ID" value="XM_010703936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZ55"/>
    <dbReference type="GeneID" id="22578299"/>
    <dbReference type="KEGG" id="lpan:LPMP_331460"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330020700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_331460"/>
    <dbReference type="eggNOG" id="KOG0660">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07834">
        <property type="entry name" value="STKc_MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000040">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000564">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="21"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="370"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIO01438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="408" mass="46677" checksum="7C7EB8378784926C" modified="2014-11-26" version="1">MPATKSLAELQAEVCRLDDRYRLERIIGAGSYGIVIRARDIKSDNCLVAIKRVNKEIFDEVVLAKRILREIKLLAHFNDDNIIGLRNILTPEDPENFEHFYIVMDIMETDLKQVLRSGQELTEAHIQFFIYQVLRALHIIHSAGVIHRDITPANILVNTNCDLKICDFGLAKEENDQGEYMTDYVTMRWYRAPELVMEGKDYSVQIDVWGIGCILGELLGSRPLFQGKDRVNQLDKIVDLIGTPSDEDISSVGSAAAQKYLKKKGYRPRPDWRQRYPNASVEALDLLRRMLVFNPKQRITVLQAMRHPFLDQLHDDADDSITYTPFHFDEQKQKTVLDVKRAIYEESVKFHKAHQSSMQTTSMNNTFNSISMPAPSVATEGEGRSAQQTIEKDIPESTTDGNFDRDQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S097</accession>
    <name>A0A088S097_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_320880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO00975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701775.1">
        <property type="nucleotide sequence ID" value="XM_010703473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S097"/>
    <dbReference type="GeneID" id="22577829"/>
    <dbReference type="KEGG" id="lpan:LPMP_320880"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320013800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_320880"/>
    <dbReference type="eggNOG" id="KOG1674">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="337735at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd20558">
        <property type="entry name" value="CYCLIN_ScPCL7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012389">
        <property type="entry name" value="Cyclin_P/U"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF108">
        <property type="entry name" value="PROTEIN CNPPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027110">
        <property type="entry name" value="PREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0195">Cyclin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR027110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="164" mass="18955" checksum="D9EDAC9DCE2D31D2" modified="2014-11-26" version="1">MPPLAQLCALALQYRCDLSQELDQNIRSCFHSSRVPSISLWDYVRRFAKYSVCSEECFILAIVLMDRYVCKTKIPITLRNVHRLYITAMTLSVKLRDDSYYSNAYYASIGGVVNAELNVLELELLDIVQWFTWVEKSVYDAYVCRLEALFGDAMPKRMIASPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0D9</accession>
    <name>A0A088S0D9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_340730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702499.1">
        <property type="nucleotide sequence ID" value="XM_010704197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0D9"/>
    <dbReference type="GeneID" id="22578577"/>
    <dbReference type="KEGG" id="lpan:LPMP_340730"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340012800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_340730"/>
    <dbReference type="eggNOG" id="ENOG502SHI4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266236at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="704"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="763"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="823"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="870"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="823"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="973" mass="101702" checksum="DAD3545F54962568" modified="2014-11-26" version="1">MAHAHTDPKSIDHTLQSTYDELRRGENQHYRSAEARYTNHVKELLGNLEHYLETCGVQLPTEVQEGSEITAAAAAASEQAVFVVSSRGRLMGTHRVSQPHCISGRSAPASAAVSYVKCDRDAVSQQEETSNNLSARSSGPVYSGWGNLATPCEARRGSSVANAHLTISSGPVAAATSTLHSTPLQSGQAHAMSDSSFSSLEAAYQRHPTPSKKSVCTANSESRASLLYNSQQATRAHTAYSPSSTFILVTVGADDNAEGNIAPHVYSNDAAGVDSCSVDSASAPIVAIINSRDSGDSGPRSRRRGGSPAMRSPPAPPPTVQDYCTGVGARGSLYASGDGVSRSCRTYPIVSNAIAGVSDADSGAARTTAGHDRWGEFGTFVQSITETRQKRNMAALKRAAATRCPLPDSANGALIADHPIVTRDVERGSSGAASPLFAMVAPSPGVTPKAGFLLPYVLSTGTSMTTPPTPVLAVAAGGQVQPSPLDWCGTKAHAYPLPLQVAHGAGSDAVRALAAAGAAAETAGSPEMADVEIDKLPSPSSGALSFPVPMATAPPQHCVGASDAGVPLAGHRLCPRGGDGIDSVVYYQHTQRGLVPPHPRTSAGAVAAAVLARSPEKEQLMRRLQAVLKHSVSVTSSVQPSALPSAVAAERQLSFSDGAAWGTGKVQGQHSAVGSTRTPVSALLRSPQSPLQIQLMSHYPIPLPSTTKTNNASDGSAITRRSVSSSEHKIGDTRGDVAGGVAWDGSWDFLQLATAAVSGCPHTFSSKDISSEPATYHSVSRRTVQSKDADGDGDSEEDSSGLPRCDHMPKEAYRAHRFVDGSNKTATVTTETPPGGLRAGGGWDMGSCTTARNPSAWTYAKEKIPPSFVATSWMRPPRSPPGVAMQSDSASDGYPPGLTKSDIGNFSRAEEEEALRARRRHSLGRRGGLTGSQQQSQRDVGERQPFSADFTSAHAEKQQLMQRLRMVLSRPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0Z9</accession>
    <name>A0A088S0Z9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small EDRK-rich factor-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_010300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SERF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009370">
        <property type="protein sequence ID" value="AIN95131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696673.1">
        <property type="nucleotide sequence ID" value="XM_010698371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0Z9"/>
    <dbReference type="GeneID" id="22571759"/>
    <dbReference type="KEGG" id="lpan:LPMP_010300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_010007300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_010300"/>
    <dbReference type="eggNOG" id="ENOG502RDZ8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18018at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007513">
        <property type="entry name" value="SERF-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040211">
        <property type="entry name" value="SERF1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13596:SF0">
        <property type="entry name" value="SI:CH211-39K3.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13596">
        <property type="entry name" value="SMALL EDRK-RICH FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04419">
        <property type="entry name" value="SERF-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small EDRK-rich factor-like N-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN95131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="59" mass="6777" checksum="CB5C19DBC7FCA9B8" modified="2014-11-26" version="1">MTRGNQRDLAREKNMKKQQEKSKGHRDNDLSYASRKEADAERMRQKQAAADERKNAGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S103</accession>
    <name>A0A088S103_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Membrane-trafficking protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_344640</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702883.1">
        <property type="nucleotide sequence ID" value="XM_010704581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S103"/>
    <dbReference type="GeneID" id="22578969"/>
    <dbReference type="KEGG" id="lpan:LPMP_344640"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340054200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_344640"/>
    <dbReference type="eggNOG" id="KOG3088">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="242866at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007273">
        <property type="entry name" value="SCAMP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10687:SF2">
        <property type="entry name" value="SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10687">
        <property type="entry name" value="SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN SCAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04144">
        <property type="entry name" value="SCAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO02083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="220" mass="24973" checksum="7E80C364783BE78D" modified="2014-11-26" version="1">MVIVTEEMVLEKERQNAARREALNKRSQKLSHVTEPDPNFPPECCCVKPIIYHNIREQVPVPQQRFMYILAGLYITLMVLIVYNIVAALVAFILGGNVTHFGLSFLFLLGIPGAWIAWYYNVYCAIVYSSRPRQKLALLGLFLGVAFDVWMAVGVTGFGGCGWLYAFSLMRTVTSFVMILISAILWSLHGFALCVVMLRYWRVSGTLLRHRENIYGQSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S155</accession>
    <name>A0A088S155_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_343250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01951.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702751.1">
        <property type="nucleotide sequence ID" value="XM_010704449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S155"/>
    <dbReference type="GeneID" id="22578830"/>
    <dbReference type="KEGG" id="lpan:LPMP_343250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340038900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_343250"/>
    <dbReference type="eggNOG" id="ENOG502S3FY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272369at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO01951.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="675" mass="75853" checksum="065909132B7B9151" modified="2026-01-28" version="2">MSQARFYTRRLALGTAARAGRRETAYLRAVVQVAPHVMVLASPVITLRRTLHFSSTPTSLCSPSPLPLDALVDEVSPYVPTTFTSIQQILRQLPPELMERVCDPVCGGLWPLLSRYRERFESKMIGQVHVVRSRHKQRQSAPPHRRLNAGDVVRQPLAVPSSLCSSLTTKASESNSVAARAILTELQQLFPNYLVPVKALWATVPEAEEQLMRRRVLDALWSPQNRGWLIFHEHPAHCTSRNSSADAAELTHVYEHGYVQLRLDPVVGDNGAAAPTQQSPNARMAGHEVQPYEWYRVARVLPTIATELLFTGELQRQATLLLPPGRDVWHVLLSAPALFELHYVVPTAGESVQQSRAPSLSADDSSSAPLCAAYDATLPPSFCASVYVRFRLEERFVPPDMAGAHETSILRELETLTADRAASVCGLSARQRRRKRKLQRQLAYLRNPTPYFDERVLAQHLFDLLPLRDGVHQSALLGSLPQTAVQAFPQNVAELLQARSDLFHLSDARHGVLVQRADAPKVAQRPIESVTGEEILLHLFSTYSLRSDPQEGTTISRSLPRLPRLVRERLFTMQDIVTEVLILYPDKVEVLACRSPSISSLSSSSSPHTSEDDERALRELRTVRGRRDFLVPFRFVGEWQDKLTEKYVKQQEKDRMKSIRARQSSAVSHRSPPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1A5</accession>
    <name>A0A088S1A5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_344220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702844.1">
        <property type="nucleotide sequence ID" value="XM_010704542.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22578927"/>
    <dbReference type="KEGG" id="lpan:LPMP_344220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340049700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_344220"/>
    <dbReference type="eggNOG" id="ENOG502RSRM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="348976at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050185">
        <property type="term" value="F:phosphatidylinositol deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006505">
        <property type="term" value="P:GPI anchor metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039529">
        <property type="entry name" value="PGAP1/BST1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495:SF7">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495">
        <property type="entry name" value="NEGATIVE REGULATOR OF VESICLE FORMATION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="884"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="940"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1029"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1062"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1095"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1128"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1176"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1244"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1270"/>
            <end position="1289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1292" mass="146261" checksum="852498FED3F12C4A" modified="2014-11-26" version="1">MMNNVTRFMGLCVLRAAYVFFLLLFTLFATGAYNWALKVYRTEPQNINPVMYSLFTQINVSAYAPTMREKYYRLWRTYDWMADSYAAPRVDGVYTRVPIVYVHGNGGSYYCARSLARFVYEANARLRQQAMRDYRRHVKRQLFQEYRANESLEEPEEGMRIPAWLQHRVEEKLVREEVPLLGVEVFSVDFLEESSTQSVPITVKEARFLNHSVHLVVEGFLRTYTDVLAAPPVTVFDSETLGKNDTRHTSPTAKVPAAAKKLLKEVEKEYSRSVCSHASLLVSGKECQQAKHLMKRFSTLERVRAEVQRVQQQGIWIWAESLGGVTTLLAAILAPHLYAGVIMVGTPIRYPPLFFDHASVWLYEIIDAVVLQRYPAPEDVKRVSHSSITWKDMVADAKHPNDLLFDLRAVPPAELHLRLRNLTLLNINGGTLDDVVPSISGYLQRSTPRPPGTLVNRSLLMQEGGYRRDISTETLRGCATAMDHRGLVYALQFLQHSADSLVQAALLPNANAYFGHEKKLPSLRRDRLFPTVVETLDTHRFDEQRLEHIFMSSVRDSITGKYVKEAKFRALSEQLKQLCVDSDVPIDYNDLPAYDEADSSSGYYNGTELLNVLMGLTTLAPEQVFVPNIQLFYDQERETPILGSEVHERAATLLHLPTTQKSTKSIPGRTLQTAVSFSIYRQMKKRRHRTWLWPRFCMLVASDQGLGTTRAYLQYDKIDLSAFADHASSHSLPRLLRGFGGGVQVHTQPGYALVRGVDSALLEPQLQVRTDDTAEVFPLVMCGSLHSFYLALRGHGSLPADEPEHQLQYFYGPFHKNLHNFTYRWKPFSTYPPLLDETYLIYTLTDNRGARPEVQLPTYSMLQDASLGSPEYWVWLLVLWPQRWLAAFSMYTGIVRLAGASVVLFFTLFIVLGMMDEKICATQSLKMALWRRSPFRRIRVLPPLVGMMMMGLVLEVVTGLWASTALRVCLSTDPPPNVTEAEMTARMSIWEKFTLVALYGISPSYRACRFSWIVMQSVPVWSVLVEELATIYLGFGIASALLVLILGYLAAVGAITWPLRRLVLLPLLRSAPALLALLLGLGWAAPTVLLLKWPSFPLCFVDVVAASLLAVPVWMLPRWTRPGYDYRLVFLFFSLACIFPSHFNGLVLTIRNAVMLRNSPAAFADAERYTPSRPQLIVFGVVQANLACAYTSLFFILRNEETLQTAGRKKEKRAKTSALTPQSEVSDGYVLGDMGRRAPRLRSLVEVLNTTFIFASVWASVVAMRRPIEGATSLLSNMTLLGYLSTYLLREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1P9</accession>
    <name>A0A088S1P9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_040930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="AIN95416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703738.1">
        <property type="nucleotide sequence ID" value="XM_010705436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1P9"/>
    <dbReference type="GeneID" id="22572052"/>
    <dbReference type="KEGG" id="lpan:LPMP_040930"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040016500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_040930"/>
    <dbReference type="eggNOG" id="ENOG502SIKT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266161at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="331"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="447" mass="46030" checksum="66D23D90E18B7117" modified="2014-11-26" version="1">MSSTIPWYCRYGVHGDFTKEVNVDGTVVYRTREQRCDCTPPPLCSLASSMAPPRPHPPQRKSRRGRATGIGRAYITPPWQDAHVPLPLSAAPRPPGEMDDMRLHVLVPPLALDSAVGDFYAGYVSSTSHDITAALPFIPVIRAQSALAGVVPFTAVGDPPSAATGPLGVGGCSDMLPGTTSPAPPLLQQGLLSPSVPPLAAAVAAPLPVCTTESHTVDRLCGFVFCPTCGQRVAAAAPGTSETAQPTPATCPMGPHVALDGERGTQAQGATLVGRFCFLCGTDKQAPTCVAEASVLPPSPSRQQPPLAATEGHTINAPTKDEAGASHTLSPPAAGGNPAAATSATTTTPPPVPTAARAAPPDLHLAQDMLTVDELISHLLSNAADNDGKLRPPCGLPQCRLCDPSAAAPSASPSAWTFPPWRCGLWGTAPVMCGSPAVAIIHHHYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1T6</accession>
    <name>A0A088S1T6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_352310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703168.1">
        <property type="nucleotide sequence ID" value="XM_010704866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1T6"/>
    <dbReference type="GeneID" id="22579260"/>
    <dbReference type="KEGG" id="lpan:LPMP_352310"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350029200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_352310"/>
    <dbReference type="eggNOG" id="ENOG502SGI6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265615at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13561">
        <property type="entry name" value="DNA REPLICATION REGULATOR DPB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13561:SF20">
        <property type="entry name" value="DNA TOPOISOMERASE 2-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839191" description="BRCT domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="4">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="176"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="264"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO02368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="370" mass="39962" checksum="6EBF9557E864E914" modified="2014-11-26" version="1">MFCGHTFLVSLAASPLTVAELTRNGARVVYDLDDKTPVTCVIIAGGNQLGTSARCSRGWTEANGLPTSMENRIRASRITVVYEHWVHECLRKSRLLLPCRDYPDTIAYDPYLFAGLRFTTTQLPLQLKANIIALMQFYGATYHNHLLDTTNLLVYSHMRLSPNSLRHAVSDPLAPLPSIADRRDTGAQSSIKEAEAANTCPGQRLSTGPSGDNPAGAAVPSLTKLAVARQHGVTCVTPQWVQLCLNAGELQPARSALAPAPPTRTMSPPSTNSSATMKADAPVSNVTDANELFHCEEEVEQWISDVLMCTPHSGGATTDACAVRLYGPSWCTIPGQKEEVAAARETLQLAAQLCSSGTSASKTRKRRRAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S293</accession>
    <name>A0A088S293_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L37a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_351990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL43 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703136.1">
        <property type="nucleotide sequence ID" value="XM_010704834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S293"/>
    <dbReference type="SMR" id="A0A088S293"/>
    <dbReference type="GeneID" id="22579228"/>
    <dbReference type="KEGG" id="lpan:LPMP_351990"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210025000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_351990"/>
    <dbReference type="OrthoDB" id="268422at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.30:FF:000002">
        <property type="entry name" value="60S ribosomal protein L37a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00327">
        <property type="entry name" value="Ribosomal_eL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002674">
        <property type="entry name" value="Ribosomal_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050522">
        <property type="entry name" value="Ribosomal_protein_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00280">
        <property type="entry name" value="eL43_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01780">
        <property type="entry name" value="Ribosomal_L37ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO02336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="92" mass="10313" checksum="96FAB5DE4EEB29D4" modified="2014-11-26" version="1">MAKRTVKMGVMGRYGTRYGANPRKRAKKLEVSQHAKHFCSFCGKFAFRRKAVGIWRCDGCSKTVAGGAYTLSTPNNSTVRSTVRRLRELAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S294</accession>
    <name>A0A088S294_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_352420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703179.1">
        <property type="nucleotide sequence ID" value="XM_010704877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S294"/>
    <dbReference type="GeneID" id="22579271"/>
    <dbReference type="KEGG" id="lpan:LPMP_352420"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350030600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_352420"/>
    <dbReference type="eggNOG" id="KOG1201">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253736at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="305"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO02379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="408" mass="44310" checksum="809E538A7860BEEA" modified="2014-11-26" version="1">MILLALTCGTLWVIWSIVSFFMYRPRKISGATVVVTGACSEMGRRLCMQLYARGARVIAWDYSKIKLQELQADVLKATEGVESADAASAQGDDRIAGSVHSGTFAVMVVDVSSQLQVQRAAKELDGPLDMIVHAAHAYPFKRLCNRTDDSAERIIQTNLLSPLTVVRQLLPLMLSTSCSSSNASVPLKATQRVGDYAQVVNLVAAASSYTLSSDSPEYAASQWGMVGMHYSMREWISQQRSEYMTGGGNDALSEKKLPAAAATRARQPVREVRTTLLCLNEIQYRVPTIASSFFSSSSGKSTAVLATPSSSIGSSEHDGGDGSGARGRSTSTYRSPCAQLMQKRNAELDKAAVCCVKAICRGQERYCHTSPWATTVIYPLLMVCPVPWATRLLRWMQHMPTATAVAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2C1</accession>
    <name>A0A088S2C1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_060570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703938.1">
        <property type="nucleotide sequence ID" value="XM_010705636.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22572263"/>
    <dbReference type="KEGG" id="lpan:LPMP_060570"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060011400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_060570"/>
    <dbReference type="eggNOG" id="ENOG502SANS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267538at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="748"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="855"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="893"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1126"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1243"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="748"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="861"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="919"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1156"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1259"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1278"/>
            <end position="1291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1342" mass="139167" checksum="0CEA1AE17B1A9895" modified="2014-11-26" version="1">MTPLHGISWSSSNRGGPDAGAEENLHIVTTVDADRLGSARSSTSSLELQWSLCGCAADAIAVQGRYQVTFRDAFAMTTVAAHMAAAGADGGSSWQGAVSLVPPLSSSTSSYSLAQQLRRVSALLGLDSEGSPPEALAAVPPSASLLDWPEEFLWNLLVSLLSSLALVHSAGLHLFGQMTAADVLCVACTPTLPRQLEQTWADVAAATAAAAGKEDVRRSACGTVSSGRMNDDCVPTHKEADAIFRRFCSIAVPSVLLPQATVTAATPCHHVFFVLHPSPELFLQKGNDRAHVLRQSVPSLSAAQESKQTTPAQQAQHQAADLASVGRLMSLLMELRARWRQRWHGHADTAAVPSSELAFLVRKLSECGGPSASSATSTQSPTALQLLQLQALRLRTESWYYRRLAEEACDRLSLARRWLESADAGLLRPSLATLSHARNSDTEGQMREAQLADREAQLTDREAKLNVVLELYGLTHEHLDALKLSQLPSAQERTSLAALSPALQSDAAAVGAPAKLTSSNRGTHTAGCVGADQRTALKVRNEDSLDRLLTQTLLQQQHHLAGAAATLLAGVTAEDGETPASTRDGRYLSPQATTATASVVPATTAGATDGEVLLGLSSVARRTTADDTLLLTRAAAPSMAAETSPVPPTQRHLDVEGIPEGDVATPPTAAAAGHHFNDESRVTVVEVDLDAAEDDGRGINVASQASASPTAIHAASAGGLEGRAAWAATVTSPSALLYSSTAAVTRQGAQGWPQPTSQQQRQQRQLFSPPLHTSPFLDMQTPMRSPALPNMGYPDGSAGGTAASPGAGVSSGGGRSHSKYSALSLLRTPPSARRRGTRVGTAAAVAAVGTRAAPSFFRSPSLHSPDSYRSSTRPHSAPTTDVLASAAAVLSPHVTTERSLPQQRQHRRRSSSRGSAGDNSGGAYAGALGGLSPPTEGYRQQRNGDAAAWAHQQLTALEEMQTMLRAQQPPTPRSRASAAAATCSRSPDVAALACARSPATPLLAPRVAAGRHSSPTAASSEVTPVRGTMPSYCGDPAGMCQMENAHMRSSDSRSGARHSDDWGGSTSAARDFGGVAIAERPRVLLSFTPPYNMSLASSPSIYQTPAETMTSAEGGARIAYAAAKSSETQSGAAGQRTPPAVQHPTTTRLYGGASHEPTSSLSPPTRTKIGCDDAVTVARRGNNNRSSVSSVFHSSALSASGAVARGNNAADLRQRSPPQHATSSPAMVSTVRSSAFAFGASAGISSHGTGGRNAHRPLSSRTASAHTTGPSAGGTNARGTVMSTSSSRVSGSHGGGGGPLQRPGDSYSPSASWASFAYAGASRTSSTTAVELLRRLRANTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2J7</accession>
    <name>A0A088S2J7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_341530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702580.1">
        <property type="nucleotide sequence ID" value="XM_010704278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2J7"/>
    <dbReference type="GeneID" id="22578658"/>
    <dbReference type="KEGG" id="lpan:LPMP_341530"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340021300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_341530"/>
    <dbReference type="eggNOG" id="ENOG502S1SX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270285at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="286" mass="32366" checksum="1B510453B1804B2B" modified="2014-11-26" version="1">MSPQIVERLGGFSRCTTLLTFAIHFLHSLFSVVNFLSWVNTPESRLTHNMKIVYLSLTIVCCLSYFLGASVFYMWAWRFPEPEEVAKRRRVYGVSINLLFCDLPIFIIETKIVRQLNFPAAIMGFTYVLTCVSFSCSVLRVWFFFMVRFIKFHFPTAWSIGSSYPTQATVAVRREMDVRNYTGGGCAAGDDGGSVTPPLTAAGHTILLSRNSGLYSDDRASTTGLYHTLTPDRARSDIYYSPPSSHYHTPSSGDLSTPREQNQRRYRCGMGTRLYRPRSAAPPLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2N4</accession>
    <name>A0A088S2N4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Acetylornithine deacetylase-like protein</fullName>
            <ecNumber evidence="11">3.5.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_070300</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M20A family. ArgE subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.16" evidence="11"/>
    <dbReference type="EMBL" id="CP009376">
        <property type="protein sequence ID" value="AIN95716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704038.1">
        <property type="nucleotide sequence ID" value="XM_010705736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2N4"/>
    <dbReference type="GeneID" id="22572365"/>
    <dbReference type="KEGG" id="lpan:LPMP_070300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_070008000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_070300"/>
    <dbReference type="eggNOG" id="KOG2276">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008777">
        <property type="term" value="F:acetylornithine deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03894">
        <property type="entry name" value="M20_ArgE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000003">
        <property type="entry name" value="Acetylornithine deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010169">
        <property type="entry name" value="AcOrn-deacetyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050072">
        <property type="entry name" value="Peptidase_M20A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01892">
        <property type="entry name" value="AcOrn-deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808">
        <property type="entry name" value="ACETYLORNITHINE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808:SF31">
        <property type="entry name" value="N-ACETYL-L-CITRULLINE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="10">
        <location>
            <begin position="177"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN95716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="397" mass="43055" checksum="AA4975255C2DAEA3" modified="2014-11-26" version="1">MASLQHVRDVLAKLVSFETVSIRTNLPLIEYVQAYLAECGVKQVTVMRSADGIHANLIATLPSADGRVEGGLILSGHTDVVPVDGQKWDSDPFVLTERGGNLYGRGSCDMKAFIAVCLALVPGWVRAPLRKPLQIVLTYNEETTFDGVRQLMRERGQDLQKCEGCIIGEPTMMDLVIAHKGISFSYLTFKGRAAHSSLQTAGYNSIEPAMRVFQKLFEMRDRFASDGPFEEGFHIGHTTVCPALTTGGNAANTIPAECSIGFEFRNVPSHPASTINKEIWDFIRAETERVKLACPEGGMEVVRRVEVAPFGGQSDAPVVKALLAASPEPRAVTKVSFCTEAGEYQAAGINSVVCGPGNIEQAHKANEFVSLDQLDKGLLVIRRVVQLMCGGSETSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2S3</accession>
    <name>A0A088S2S3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Kinesin-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_355270</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703458.1">
        <property type="nucleotide sequence ID" value="XM_010705156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2S3"/>
    <dbReference type="GeneID" id="22579555"/>
    <dbReference type="KEGG" id="lpan:LPMP_355270"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350061200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_355270"/>
    <dbReference type="eggNOG" id="KOG0244">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="123929at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000216">
        <property type="entry name" value="Kinesin-like protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="9"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="401"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="585"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIO02658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="625" mass="71151" checksum="232E169FEA05430E" modified="2014-11-26" version="1">MKMNLKSSTCRSFVRVRPFTPWEANVSPEGCSIPRGILVWDGNNVISVLDPQNLFEVRQNGIFSVGEVLWSFTEPGDETVKSANKQRPATQQDVYNRVVAPMISVIVEGYSTAFCVAGASSSGRFYTLYGGEAEGPNRGILPRFVEDIFTYFKKNSQANSTLNVELEAVDISGETYVDLLAIGRNGSNNQAGADSLKLHSTPSGPRLVGVNSVDVESASELLKVIQKLHGIVEKRNCTHTVSLRFTETLEFEDPEDANQSVSKSRHVQVLFVLLRNMPSAFQRCLDVAVSHDSGENPLAKVPVRECALTRLFPSLLQQGFHLSVISCVSPYYEHMREDLNTLQFSIKVRKLNGNPQLLQDKSFVEMRRLADEVKDLQVQEKKTHEAVAVVQNELNAREVELMKQEANYNKALKNITELQRQVKLATIGRNMEAERSNCVRKELHKELNQKRAEIKNFQEQQASASITKCKLMREADDAKVRADEMEARVRMQKENARIYEKRLNEYSKEDKETAKIEAFNIAHPDEQRNIIINESDEKRNADFEIKKIEMERSSARASYKVDDRIRAIQEEYDLAYNLCAPCRERKKLEEEIAKYEKEISEMEEEIPRLQAAIDRNKIQCQCILM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2X5</accession>
    <name>A0A088S2X5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoglycerate mutase protein, putative</fullName>
            <ecNumber evidence="3">5.4.2.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_080060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.4.2.11" evidence="3"/>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="AIN95816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704138.1">
        <property type="nucleotide sequence ID" value="XM_010705836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2X5"/>
    <dbReference type="GeneID" id="22572468"/>
    <dbReference type="KEGG" id="lpan:LPMP_080060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_080005500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_080060"/>
    <dbReference type="eggNOG" id="KOG0235">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="354304at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF44">
        <property type="entry name" value="PHOSPHATASE C1620.13-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="8"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="185" mass="20320" checksum="0509F9BC80D4263A" modified="2014-11-26" version="1">MAYIHICRHGQDMDNAHGILNGHRNEPLSDLGRSQAVTVANKIKESGVNYSIIYSSPLQRALDTASVIGAAVGVQVQVRADLIERDFGVLSGKPYSDISKYAGDKLLQGDKVLYFLEVEGCENFDQCYKRAQGVLADVNAIHAGEHVLLVCHGDIGKMLQAAHAKVEWQEGLRLPYFVNTEVIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3B4</accession>
    <name>A0A088S3B4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_355840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703514.1">
        <property type="nucleotide sequence ID" value="XM_010705212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3B4"/>
    <dbReference type="GeneID" id="22579612"/>
    <dbReference type="KEGG" id="lpan:LPMP_355840"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350066900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_355840"/>
    <dbReference type="eggNOG" id="ENOG502RXD1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277587at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052586">
        <property type="entry name" value="ASCC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21494:SF0">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21494">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 2 ASC-1 COMPLEX SUBUNIT P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="658"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="715"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="445"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="658"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="671"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="726"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="738"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="748"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="794" mass="87057" checksum="36199A9B68535271" modified="2014-11-26" version="1">MASSLQDAFPDAGGAVCSTFFSSVDLSEKLWAGIERLAEADDITFWIVVTNHDRLPVVLVNVITAVDHAHSSHSKVQRNAVTPNDEQRVIEVLIRLATGTDPCLRRHVDPASLAARLSVLLPWKLLFPVSLLLLRHSGAAASVALTSLILLNPGYLCTLNVFMPTWWDSVNRLAVRCTRELQRGRFQRQPGDILSSFEQVYRLTKHLWAVVQCAPFLSDYMSLPRTLRGLRVIVDVLSPVLQHFIMVCDDLTPRRPILSRANSVIVNAAINTSSALVLYHTYTTQGPQRSQNSDSYCIPQLINRTYNHLREHLRQHSCGIVVDTLQAYGNGSFLSLIHFLYPSGRFADDAGEKALGQVMLTLTKDTSDSNDFADAARGARQRFFELLLLEIVRQGVHIDDLLARRLVTTDEAAKLGASEDTITSALTNPPAGNAVTTAETADGGPLPSTSSPLPAATSTVDDPLVAMVMEVFPQYSAAGIRAALNFYSNDVEQFIMDASMENLPPHLVGPLTASGQSDAELAAALAAEETGMWKPPAAAAASAPAAQSPATRANPSTHLVLYDFDDSFEPDALYRFMGRDLYEMLTGSDGDDGYTDGCAKGNEMDEDAAYKITINDPQAYMSDAFDIDEEVKAKIRMLNEIMYEDELDDGQQDVHLAGGDIIDDASGGDSDDNRGRGRWERERHRGGSTADSQAPRHVDAELSAAFEGQELAPASAVGLASPQQQREPRDEYHDKRYHEKRSKHRLERTKQIQSERTERVPAYANKKKTSKAKVGGAKGSLQRAVKQGKFDPNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3E9</accession>
    <name>A0A088S3E9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">E2 ubiquitin ligase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_091010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN96016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704338.1">
        <property type="nucleotide sequence ID" value="XM_010706036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3E9"/>
    <dbReference type="GeneID" id="22572671"/>
    <dbReference type="KEGG" id="lpan:LPMP_091010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090014900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_091010"/>
    <dbReference type="eggNOG" id="ENOG502QXH4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2127714at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11685">
        <property type="entry name" value="UEV_TSG101-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051728">
        <property type="entry name" value="RING-FYVE_E3_ubiquitin-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008883">
        <property type="entry name" value="UEV_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14879">
        <property type="entry name" value="CASPASE REGULATOR, RING FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14879:SF5">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05743">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51322">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UEV" evidence="3">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="208"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN96016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="253" mass="28122" checksum="D9B87206DD729985" modified="2014-11-26" version="1">MNDDVVRFFSNASHYRPEVLRRIVMEIDNVCSSLCFSRKITTWGNTEQPKICLYGGLSVGFPMIPRADASVESGVASEPVIQSLVIPIQIWISHQFPIEPPFIYLACARISGNSRIPGSVNASVLKIVNNHPNVDFTGLCFCKELAEWRPSTSSLCFMVKRLGRALEKSGRCPIYIDQEICGNSLTIDGNNSGSDKKNIIDNMLPNSCLVCYRKKDTVLVPCGHFCACMSCAANLTECPVCRSKIMVRQRVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3F6</accession>
    <name>A0A088S3F6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Branchpoint-bridging protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_355550</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BBP/SF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703486.1">
        <property type="nucleotide sequence ID" value="XM_010705184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3F6"/>
    <dbReference type="GeneID" id="22579583"/>
    <dbReference type="KEGG" id="lpan:LPMP_355550"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350064200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_355550"/>
    <dbReference type="eggNOG" id="KOG0119">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6777263at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045131">
        <property type="term" value="F:pre-mRNA branch point binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000100">
        <property type="entry name" value="Putative branch point binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF45">
        <property type="entry name" value="SPLICING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KHDC4/BBP-like KH-domain type I" evidence="4">
        <location>
            <begin position="133"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="238"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="256"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="269"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO02686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="284" mass="32389" checksum="0D6B74F699C8F781" modified="2014-11-26" version="1">MPKETVSRWSESRYTNLQVPSYVPSEALMHEDGQFLRAFLLRVLANDMQRMLATNTCAAYFRNIPLEPEYDASGNRTNTPENVVMEKRLRVMDDISKLLRTYVERAEYAANKSKDINRRIYFTAEQIETGDFGALIGPRGLVHQQLEKETNCHIVLVGRGITNPLKDTNPNAAAMALEDPHVRITATTEEDLQTAAERIEWILSDEPEAVEFRENNRRRMAQVDGRYDPRTWMTAAEKRKKAAAEKAAAAGDDEAGAEKGRKRVREEAPIEEEDTELNEFLEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3H2</accession>
    <name>A0A088S3H2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_091210</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN96036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704358.1">
        <property type="nucleotide sequence ID" value="XM_010706056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3H2"/>
    <dbReference type="GeneID" id="22572691"/>
    <dbReference type="KEGG" id="lpan:LPMP_091210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090017600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_091210"/>
    <dbReference type="eggNOG" id="ENOG502QXH3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5855668at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839190" description="RING-type domain-containing protein" evidence="4">
        <location>
            <begin position="36"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="177"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="340"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN96036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="395" mass="42700" checksum="10183164D45802A4" modified="2014-11-26" version="1">MSRVAQHSSAASASMGERATLFLMTLFVVLGCSGAVQNADARLERQTYVAYRTPHLCSYEIMASVACPQTKPVCCVASSAIRCCAGTTSCGNCTDDIVGYEMPKSSVIIGCFSLSVLVLLGSIIMSGVGRHLAWVLERRRVIENYRKHLLLRRAEAREFKKELAETEVKDIDDAVGCVICCSRHIDVALTPCGHVCCCRFCAKRLRECPVCRSALQRCFDLPLYYVKQLLSASGTEEKDNGSGGRESPSSPTEMYPITGDGIVATTTWEARVEDICATGQAACAPTTTGDCSVESAMAPSGSSCCWSSVERPRRSTIRVIGAVERGMINPLRGRYTRVQYSEEDEDERNGRSATCSTPLVPHVPPAGAATSPTEVRITAADDSAQHSYGCISREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3M3</accession>
    <name>A0A088S3M3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amastin-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_100220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696744.1">
        <property type="nucleotide sequence ID" value="XM_010698442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3M3"/>
    <dbReference type="GeneID" id="22572758"/>
    <dbReference type="KEGG" id="lpan:LPMP_100220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100007400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_100220"/>
    <dbReference type="eggNOG" id="ENOG502SIPQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="263017at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009944">
        <property type="entry name" value="Amastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297:SF4">
        <property type="entry name" value="AMASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297">
        <property type="entry name" value="AMASTIN-LIKE SURFACE PROTEIN-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07344">
        <property type="entry name" value="Amastin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="318"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="485"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="508" mass="56673" checksum="4AD5E3EE7E45F53E" modified="2014-11-26" version="1">MSYTEHRPERPEGYTQEEGAALSGPKESQPPMASMEPVKSNDVDAPVTEDDLKRDFDSEVLDLARDKSLNWKERAAKRKDLLSRQAVVEKERERRVIATLEARLPRPDWYSSDNDDESIQSDVEAHEASELKMQPEGGAGFVFRVVYTVLSTVAFIFHLTSSCPIPWMRSSSGRKYGVWRATGGGEPDLKVSDIHDCSYEMQYWQAVAATSVLATFASCGAMISGVLLCVNKGHMAASFILSFFSISFSLISWALVVALYRYFRCGKGAFASGVAHLDGGYALTLIGWVMHMTAIIVLIVYFFKYWTRSIHSGKTRAVRFIYVAVGIITMVFYSVGVAYTLWGKTFPAVKVSVSLWHVQVYDRETRLSTFLSHSTYKCTTITRYMRVVAALMILSTIWLFFAVVLGTGACHNSKYLKSSIIFGYASSIFALIAWIILLTMRQGRLCTGAAPIGQSYWVDMGYNGIPSGIENAEINFDGYTLREGFALIVSGWGINTLVLIFNTALWNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3V4</accession>
    <name>A0A088S3V4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L24, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_351100</name>
        <name evidence="6" type="ORF">LPMP_351130</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703047.1">
        <property type="nucleotide sequence ID" value="XM_010704745.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703050.1">
        <property type="nucleotide sequence ID" value="XM_010704748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3V4"/>
    <dbReference type="GeneID" id="22579139"/>
    <dbReference type="GeneID" id="22579142"/>
    <dbReference type="KEGG" id="lpan:LPMP_351100"/>
    <dbReference type="KEGG" id="lpan:LPMP_351130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350016600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_351100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_351130"/>
    <dbReference type="eggNOG" id="KOG1722">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270817at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000007">
        <property type="entry name" value="60S ribosomal protein L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL24-related N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO02247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO02250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="124" mass="14601" checksum="3AEE54AE1FF536BF" modified="2014-11-26" version="1">MRTIECEFSHFAVHPGHGRRYVPFAFLSTKPVLTFSRPKCFALYMRKKNPRFIPWTRTYRRIHRKTTTDRVNRRRAARAVRVQRAIVGADLSYIQEVRATRKEDRSAKAKAVRAEVAERKAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S4M2</accession>
    <name>A0A088S4M2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_354630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703395.1">
        <property type="nucleotide sequence ID" value="XM_010705093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S4M2"/>
    <dbReference type="GeneID" id="22579491"/>
    <dbReference type="KEGG" id="lpan:LPMP_354630"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350054600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_354630"/>
    <dbReference type="eggNOG" id="ENOG502RK8S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271870at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1050" mass="114000" checksum="F45CB3BDBF13EF0C" modified="2014-11-26" version="1">MQSNLLPRGGSAESRPLSAVDLQRITDILEACGVSELHGSPHIYAHPESIHIISPRDLSFLVLHADVLATHKDLLYDVRAFTGILWGMVQHADRGIEKVLCTIEDSGTAVEVNALGGDTGGTPSSSPSPALAQKFLYTHVSNMYPAIFPHLVQVFRVATLLRAYESAKARAEVRDSRRIAQVDVDVVARLASRLTDLFLYEAGERTTGAIGRAGALNVTAAYTNVGHHLFRTSESALSSVMLLLSALAARPGSDAGPILRYFHSVSAWKASALGLLITDSYAKAIQTVLFALCERRHDFDNVEEVAAKLFLQRLASRPPYQWRTFRLLYFSVQDIGARDTPAAEDQQGSSAFGQLLVFRHIQRALRLCLTTDGANNADALATVKFLRKAVQAHVHRCWLEPNMAGRMGSLSNKGNNDAPPRLLSYYELLVLAAMQGMPAADLTKDAELRRRAEQTNLSVEPEVLTPSFLRILLACCYNVPPPSDAPTSRALLSTQSTLALYESLAKHVFQIPLCSSAARSCDVNPLLATAALQTETLVDLCVWNAIHNTQEDDREATEEGAVKESSAEAAAGSVMLPSAAHARAKAGATKMTGPPLPPTPFTKTAKLSAVAATPSLPQPPTPTSALFHCIRRDVSLLFAGNEDVLQHTPGAARVRAKNFPYGFRTMTLKTVSLLFGALRTAELYHHIPPVDVLPVVAQLFALRAYYPLSLSETEAKRKVERRLLSLMHLTLAILPQEMKAAAVNQLLCRTLVPMSTMAGQANQLQLALFEGYLRSMATASAANAVTDELMLQHWVDIAVPAVTNRHSVALANAGHDFLIAAFRAEKYVSPLFVPTYIALYIPTVDIHSTTGSVSQRSTYPPLSVSAIQHFARMVRTACHGIERCDSTALARLFEDGAGSEGDATMPALSSAAVAYMAKLSPAQRAALRKVTPTNAVLLVVSALFDCLCLLWNSTPGYVKVAQDLFVAYFSGLCNLLQCTSTPVLQRVCASIEAIEVEHLRGSGSVQFQFLKYVNLVVDAVEGPSKVGIAEWFLNMNKRIQEQNYGKHSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S504</accession>
    <name>A0A088S504_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab3-GAP regulatory subunit N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_355900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703520.1">
        <property type="nucleotide sequence ID" value="XM_010705218.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22579618"/>
    <dbReference type="KEGG" id="lpan:LPMP_355900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350067500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_355900"/>
    <dbReference type="eggNOG" id="ENOG502QWHR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2019917at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026059">
        <property type="entry name" value="Rab3GAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032839">
        <property type="entry name" value="RAB3GAP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12472:SF0">
        <property type="entry name" value="RAB3 GTPASE-ACTIVATING PROTEIN NON-CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12472">
        <property type="entry name" value="RAB3-GAP REGULATORY DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14655">
        <property type="entry name" value="RAB3GAP2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab3-GAP regulatory subunit N-terminal" evidence="2">
        <location>
            <begin position="424"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1661"/>
            <end position="1685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1666"/>
            <end position="1685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO02720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1772" mass="190922" checksum="999E72F2C3C509BE" modified="2014-11-26" version="1">MAGKTPLELISVGTVTPRERGISSHTVPSVVEVLPGLYLIATIMRAKNRCLLELLRPGTTSPDGISDPFTVTRKDELQRRLSESSTSSIRHASTVNVPTTLQAGFRVPRIIQLVAEDEGVIETVALLREPLDSAFATSLEAREGSAERMNTVDGAPPTPIHHVYVHFFIGTSNGTVLVGNALRGTILAIAQFQYHHLFDDERRGDRLTTTSTAHTGASSGKPAAVWPRSEKSAAVNQSVVKFVVGQRSDALRWNSSLRFSQLSTGSASDRGSGSSAEARERSGSPTVHSGVTSVYVVHSGGKVVELSRVALDVFVRVSLDRLDGRRPHLIVEWSPETSTSTFPVAGPASEFAAHVSHVSVLAPPPGSYSSVESCTATTKYATAESTTFSICDADIVRVPSSGGASPLLSPLEAPHGFSDVLLVGGTNPLLSSFRLQPPPSGFSASNTVKAVKSMVTGMARSLWFRALGTSGTVERMPHLKKIAAPRTHTLLQADAKCTALQVDPTHRWAALAIENGGRIYVADVQSGIVAAVLKGCRAAQFTWWWTELAGARAALLLVVYLPLRRAVEVYTTRTWQRLAARHVPKGSVLLRCSGVPSEVASRASASHGEDRPAPACGGSGTAALLMDPEGNVFRVGINWVLDNSRASRARLRSSHPASPPWGAAAVWPDSEACALSTSVLRDCQTPDDFLELALRLPLPQPHMQQLTTAEGGFIVAGSNEVRAYLKQLAGLCETVHRRFAPGYAEITATPMPSPMQDILDGAPTAVPRGVTAAQCLHYVQRYASLVENYQRFLTCKNVAATLYFDPHQWTSALITPDLWKATFSIAAHPGVAAFVKTMDAYVAVTLAAHPTELSIYKKHVSTYLHQVMRGPPHAAAAAGPGSPPPRAHAPKAARVAPHLARPSNVMSLPAFLRCFYVGSTRPTFLRSAVESAEDADGSVTILGPLSDLVFGVWGVDSFLAQLPALRDVGCADDDIAHITVTWVARQAGRDLAALLCSTTVGCLAATLLSFSDEDFAAALARAPIPFISVDGGLATRAAVDCVTGLVWCCAARFVLRRPGSTVAQSELLVRRVRQLLQLWQSLSKASLLPSTSVPREVDPARSDSATSDDMAALLLRLSAVEPSYSRNAECGGSICDISGRREHAATTANHTEGDVIEVYLQRNGITATLLDGLTVPRADADADAARLFPLFSAFFSLLGEAGCVSDPDAVVVQSLPWIDSRQWAVERFHNEALRPIEQLWQQLSSTSTKCGTGASLRRSASGVYKSCLILVAMTVLQHILRPLTDVAFFFWDTDAVPDGNFFPVDGTPSGLLLSGSRTSRDYLNSVQRLSSLLERMLLHLVAPLENADRALLIQEISLALARDNALLFPLVPNFLRVQLTMWMQVLAQTPRFPLRRTQRVRQLIELILFFSEVPSLTVGDVPLTQLQSHLTIPWKVLLGGPSKRVQLQLLPAAVLKKAASPTSAPMARLTSLVATPSLSTRSTGPAISPYVAEEEDTHSTPLNVRAAATLLRRFLAASGVLYANRYGPASITAWESTSCLGFVAEDTRQVLARLGECLGLQESFPEIGNVVLMDYEIKHLFPVSAVEQAMFLLSSRSAAPLVAASNLQSFLVLILQHMTARCKGYEQRGERAAYDAALKQLRSMAQVVSEDLRAWLQEREDEMTATPESKTAKSTAGGHHSTSPARSIPYALSAESALCGSGWVTPAEHREMGRLVSSVLSMGKGNEVHKNLFHLLFTLSQWACEGYLQLPPTAQRVARELPLIVKKWEKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S680</accession>
    <name>A0A088S680_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_170280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97066.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697719.1">
        <property type="nucleotide sequence ID" value="XM_010699417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S680"/>
    <dbReference type="GeneID" id="22573771"/>
    <dbReference type="KEGG" id="lpan:LPMP_170280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170008100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_170280"/>
    <dbReference type="eggNOG" id="ENOG502SG66">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273809at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97066.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="298" mass="32143" checksum="5D611676E76A8FA9" modified="2026-01-28" version="2">MWQQEQQAAVLSAGDKGSILATPVITGASRFHVVFSRNSGSRKQRAKREGALSVAYDVSYLYAKDNKECVLRCKAAGQGPNKIFTCMQRAHRGADWVVGTELSLCGFDMLVEEVMELHLIPYEEDVDAAGADSLEGGAGCGIVTLCRTSAPTAPMASSVQSFSAPALLGSGGGRTAYAQPRMSFLRHRKPLHATAAMAPWAPHDNDPPSPKRFEGGGVPSIYAQSECLALKMGSVSMGATLTAHSPTDSPLLAPRDERCVDGSVDSDCCSLLQRQQRRRRRSATSLARELERCYPQYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S725</accession>
    <name>A0A088S725_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polyprenyl synthase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_190190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698014.1">
        <property type="nucleotide sequence ID" value="XM_010699712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S725"/>
    <dbReference type="GeneID" id="22574073"/>
    <dbReference type="KEGG" id="lpan:LPMP_190190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_190190"/>
    <dbReference type="eggNOG" id="KOG0777">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6921389at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.370.10">
        <property type="entry name" value="AttH-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023374">
        <property type="entry name" value="AttH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010791">
        <property type="entry name" value="AttH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF44">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07143">
        <property type="entry name" value="CrtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17186">
        <property type="entry name" value="Lipocalin_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159245">
        <property type="entry name" value="AttH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AttH" evidence="3">
        <location>
            <begin position="31"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN97361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="742" mass="83117" checksum="8C7515D374EA8BE5" modified="2014-11-26" version="1">MNEDWPQHFPPRGTVPNAELYDQCIDACSLQWWYANAHLMVKGEDRPSLAFFVSFFRRAEESCPTITTKHHDACMWALIDLKHQKYYADSVLDPESIEQLKLQLDPAVTGRKLEHVEAALLELLNKGRVPRPDRILKNKAVYTQQPFSITLDDSCAMRVAQKGPVRQYAFEMRNTADDVYVRLYFKTQQQPVFHGKDGRVNGMYYYYFPSMRVTGFVVVKGVKHEVKGLGWYDRELDGSVSELGRDAKYSWSWLSLHLSNMSQLNMFHGTSGNEPDTRKMIVVETRTDGSRHYHDDVVMQTKKTWSSLVTFMQYPVEFHICSASMGLDVTIHTVFDAQELGTVLVGGAGFYEGVVEGSGVCGGEALTMRGFLECKKNAAPYSSTSELLKCIGSYVHGALEEVYPLDASDSWVSENVLGRNAINRGVPADKVCDTLFRPVRSMIDRGGKSWRSLVLVSCCNALSRQYFDCRRYIAVAELLHVGSLIIDDIQDNSMVRRGEKCVHVEYGVATAINAGSACYFMAPRAARIQDLPPEKASRIYQLYFDVLLAGHAGQGLDIYGLDYLMPKVIETGDVSTLFDALDAIHTYKTGGAVGTLCAMACVLCEAPAALSEAVEKFGLTLGLAFQIVDDALNIRGFEGNLKEAAEDIKDGKITYPIAIAMGRLGAADRHTLWVILRKPTKEAADIRDAVELIMKVEAITECLLIARHRLQEMWDSLDPLLEDSFPKLMMRTLCSFLVERTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SAM5</accession>
    <name>A0A088SAM5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">UDP-galactose transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_240420</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699383.1">
        <property type="nucleotide sequence ID" value="XM_010701081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SAM5"/>
    <dbReference type="GeneID" id="22575451"/>
    <dbReference type="KEGG" id="lpan:LPMP_240420"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240008800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_240420"/>
    <dbReference type="eggNOG" id="KOG2234">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="408493at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="431"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN98676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="451" mass="49288" checksum="932547930189BEE9" modified="2014-11-26" version="1">MRSFPWSMRARRYMPNFNAMALVLLAVQNAGYLILMKYAQQADKHHTLAAGGAEPEGGEAQVVIFKASHFLTTTEVVKLILSLLWCIVDEVRAMQQESAIAEADTTPATLLRVKEAGRGSALKNAASPNGVVDEKCRLSPALGDAAEDIDAECVVAVVSLRVLVTRKRFAAVFVSRMRHAIGLDHKYKEALLMVAPAIIYAIQGLLLIYAIELLDPTVFQVLYQVRIMFLAAMMGVVLDFRLSPIRWVALVLLMFGITLAQVSAQSTRTETTIGKADEAVQSEMGKTAAAEKVSSTWSIEGTLAVLAGAFLSALSGVFMEFVVKKRCNQFHLSARNIHLAFFSVVYFLVVFLCEIWRPEVAVGGLAEFISTFFDGFTSLVWTLVAVQAVGGILVALVMRYCDNIVKSFSTAFAIVLNGMASVFLFHTALNATFLVGAFLVLCSIIMYSLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SDG5</accession>
    <name>A0A088SDG5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA polymerase kappa</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LPMP_281530</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700493.1">
        <property type="nucleotide sequence ID" value="XM_010702191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SDG5"/>
    <dbReference type="GeneID" id="22576598"/>
    <dbReference type="KEGG" id="lpan:LPMP_281530"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280021300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_281530"/>
    <dbReference type="eggNOG" id="KOG2094">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1747274at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000004">
        <property type="entry name" value="DNA polymerase IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.810:FF:000004">
        <property type="entry name" value="DNA polymerase kappa, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000054">
        <property type="entry name" value="Putative DNA polymerase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000025">
        <property type="entry name" value="Putative DNA polymerase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050116">
        <property type="entry name" value="DNA_polymerase-Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076:SF33">
        <property type="entry name" value="DNA POLYMERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076">
        <property type="entry name" value="DNA REPAIR POLYMERASE UMUC / TRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UmuC" evidence="13">
        <location>
            <begin position="145"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="576"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="582"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIN99786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="599" mass="67239" checksum="4952412361A8CF13" modified="2014-11-26" version="1">MSPAARDHYSNSHAADFEADSAALEAHAHAAPQDSHNLQTHAGMNGAQHQDHRSAGKLNFDASKAGLQQVNKDYVEHVIEEASKGSAFYQKEQRLEETRRRKAEELQEKAKSFDSISTAEKQKIKAMVDTMVDELEATRDLRRRYIHIDMDMFYAAVEEKKTPSLREKPFGVGSQQMLSTTNYIARQYGVRSGMPGFIGKKLCPELIIVPNDFPAYQREAARVHSIASRYDAQFVSVGLDELTMDVTKYLQEFPAVSASDIAHDFRDEVFLKTQLTSSGGIGPTSILAKIASNVNKPNGQHEITLLTREEVIDYVRDIPLRKIPGIGYAQEMTLGALHIHTCGGLLQHKYLLAYLFREKTLAHYLSVGLGLAETFSQRRHQARQSVGKETSFSEPLPSPEAFTRIFRKLLEQCHVRCVRDHLQPRKMTLVLKYRTFDTEQFSVALPSHTNDLKVWLEASQKLLEPHLLHYAELRLIGVRLLRFTDADDDHIDINSRSRDALTGALTGVHEVNEDFDMDADDASRDAEKAALAAEQTGAYEGQPAQPPAMPKRKIPVSKFLTDPNIPKPRLAEPAVAAAKVIKPARKRVKASKHKLHKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SDZ3</accession>
    <name>A0A088SDZ3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thymine-7-hydroxylase, putative</fullName>
            <ecNumber evidence="6">1.14.11.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_290250</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.6" evidence="6"/>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIN99976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700919.1">
        <property type="nucleotide sequence ID" value="XM_010702617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SDZ3"/>
    <dbReference type="GeneID" id="22576789"/>
    <dbReference type="KEGG" id="lpan:LPMP_290250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290007600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_290250"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="256265at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050341">
        <property type="term" value="F:thymine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000006">
        <property type="entry name" value="2-oxoglutarate-Fe(II) type oxidoreductase hxnY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="5">
        <location>
            <begin position="171"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN99976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="318" mass="36154" checksum="6E792629EC57498A" modified="2014-11-26" version="1">MFLPVIDIAPLYHDNKTDLLRVAHAIDEACRTCGFFYITGHNLPKGRMEKVTEMAEKFFALPHQEKLRINLEKSPNHRGYGTYAAEQLDPSKPGDWKETFDMGFHLPPDHPSVVAGKPLRGPNNHPTWIEGWTDLMEQHYSDMQRLSLLLLRALALALDIDEGFFVSKFHEPLSVFRMIHYPALPDEKGRVVCGEHTDYGIVTLLYQDKAGGLQVKNAQGEWVDAPPVEGSYVVNIGDMMAMWSNGRYKSTLHRVLSPGVDRISMPFFCEPNPETTISCLPNCFDEANPAKYPDIKAGDWLLMRFKQTYAYRADDVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SEK0</accession>
    <name>A0A088SEK0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_292450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700849.1">
        <property type="nucleotide sequence ID" value="XM_010702547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SEK0"/>
    <dbReference type="GeneID" id="22577008"/>
    <dbReference type="KEGG" id="lpan:LPMP_292450"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290026600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_292450"/>
    <dbReference type="eggNOG" id="ENOG502SIZ5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267326at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="601"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="647"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="765" mass="82206" checksum="2112086BD198AAED" modified="2014-11-26" version="1">MPAFLSPSQRASQQAAASLLVDEGETPYHNSQPIARFPLDDNDEVFVPVRRVQHADELSAACSPLSPAAEECPSNETEKDAAWTEVLQSSRSSQLDNHSGTHVFYPNRHFSARLRSGSGTDSGDLQYSRAPRARSTFTVDQRQIDRLAIPRGVHGTVMRPAAPNYGRLLNMAEEEERDRLREQQRYHKSLRTVKFSMAPCVERAQPARAQPPPSCPESKYPTAPATAASSEVQKAYYERLTGPKKAPPLPAADGGAPLCRTPLAEIAPSRDINSTLDRLAMPKKTVTARSEEATAPPQRGTLSHLSNARAPTQLHLQRLSHPKQQTASSHHNSHVSVEYNSYISRKRYYGGTTVISATPDMPSSTGLQPSPSHVNRRHSGRVPSASWNAVASRVERRGSSTRTSSSMASAPCAVCGTATPQQAYRVLSQPIPLTAAASHRVTVEQAAVLLPQSHPPVPADSENGSTRVQSTPAKCRGSKPPILVHTRRYVPPLEEQDAEAADQLASRTAKQESPEAPAPAPVEAVRRRSATLTVPAEIAKAPALEKEQQEGSNTTLVETPGRAPLAPVVVQAAKRASPPPSAVLAEVTAPQAVVQATKQVSSRPAAPALSRAPQGPLALETPKRHTPASCPTSGAPRHPAQRVFTDTHPSLTSASSPVPASDKVVTAPPPSVATPEKCDTVTAASAFTIEEVYAIPPLQGDGKAGPRKITHRKSHRVKPEVLQDADFAFQLEGVLPELRPFVPIVKKPKRVTKMTALRAPPSREH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SER2</accession>
    <name>A0A088SER2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Dolichyl pyrophosphate phosphatase, putative</fullName>
            <ecNumber evidence="8">3.1.3.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_300420</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.4" evidence="8"/>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701077.1">
        <property type="nucleotide sequence ID" value="XM_010702775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SER2"/>
    <dbReference type="GeneID" id="22577096"/>
    <dbReference type="KEGG" id="lpan:LPMP_300420"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300009500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_300420"/>
    <dbReference type="eggNOG" id="KOG3146">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="302705at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03382">
        <property type="entry name" value="PAP2_dolichyldiphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039667">
        <property type="entry name" value="Dolichyldiphosphatase_PAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF59">
        <property type="entry name" value="DOLICHYLDIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="101"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO00277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="272" mass="30142" checksum="D168C02B76F357A4" modified="2014-11-26" version="1">MSWSETVRFVWAYTHLSAVELQQGEVLARTHQQGAAALATPAKTPVASSGPPHWKSWAMTEVLYRQHDLFSKLFGISSIGPVAMMVLLTGMTSAPCRERRIPAMNLILYLVLSVCLNVALKEVIRSPRPAHPAAGMNYTTMNGMPSDHAQFMAGFSVYLLRRWAHTQRRRTERRKAGHLQQRKSISASAALTRSSSSYALMGLLLFATLFIGAGRIYNGYHTVGQALVGWMVGIALALVCTTVRVQRSFTWVSEKVLVPVMLVCTFWTEAIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SFF9</accession>
    <name>A0A088SFF9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_303200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701342.1">
        <property type="nucleotide sequence ID" value="XM_010703040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SFF9"/>
    <dbReference type="GeneID" id="22577373"/>
    <dbReference type="KEGG" id="lpan:LPMP_303200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300036900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_303200"/>
    <dbReference type="eggNOG" id="ENOG502S1GA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="274621at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO00542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="95" mass="11409" checksum="CC1822F0285FB56C" modified="2014-11-26" version="1">MFRKSGRCCMKYANLELTTRGEFPHGMKEPGFVKKLDKNIPWYFSTYRSMYHWPIAGEGWSDLNEPEKHHDLHMYYTLAWWKLGEGIFDADDEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SFM4</accession>
    <name>A0A088SFM4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="5">PPIase</shortName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CYP5</name>
        <name evidence="7" type="ORF">LPMP_310050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701397.1">
        <property type="nucleotide sequence ID" value="XM_010703095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SFM4"/>
    <dbReference type="GeneID" id="22577431"/>
    <dbReference type="KEGG" id="lpan:LPMP_310050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310005400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_310050"/>
    <dbReference type="eggNOG" id="KOG0865">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000019">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="57"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO00597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="229" mass="24573" checksum="E73E83C4CD510B17" modified="2014-11-26" version="1">MALRFSCALVAGGALHSYVVSPSAAAASASRPYLTPYATNPRNSRVFFDVAEQGRPLFFGVTAHEPIGRIELELFDDTVPVTARSFRELCRGSSNKSPEGVLLTYKGCPFHRIIPDFMLQGGDITKGNGTGGCSIYGARFKDESFNGKAGKHKGPGILSMANAGRNTNGSQFFICTVACPWLDGKHVVFGQVLHGYEHVKKLEAYGTPHGKPSKTVLISDCGVVQETCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SGL6</accession>
    <name>A0A088SGL6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclic AMP-dependent protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_320700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO00957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701757.1">
        <property type="nucleotide sequence ID" value="XM_010703455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SGL6"/>
    <dbReference type="GeneID" id="22577811"/>
    <dbReference type="KEGG" id="lpan:LPMP_320700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320011900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_320700"/>
    <dbReference type="eggNOG" id="KOG2814">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277832at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034237">
        <property type="term" value="F:protein kinase A regulatory subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010738">
        <property type="term" value="P:regulation of protein kinase A signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1140.10:FF:000011">
        <property type="entry name" value="AKAP7 2'5' RNA ligase-like domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019510">
        <property type="entry name" value="AKAP7-like_phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052641">
        <property type="entry name" value="AKAP7_isoform_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15934:SF2">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 7-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15934">
        <property type="entry name" value="RNA 2',3'-CYCLIC PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10469">
        <property type="entry name" value="AKAP7_NLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="A-kinase anchor protein 7-like phosphoesterase" evidence="1">
        <location>
            <begin position="72"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="281" mass="31477" checksum="FC620171F7BF2867" modified="2014-11-26" version="1">MWLQCSRVLRERAERGLYFPINHRIIDQRNTSASGAEEADIQSRYRRQLRSSFVTGETRQTEPPAWSQRTRPTHFFSLPLPTRCLLRVRVKEMHDSMLFSNAHIEPLLIPAAKLHVTLGVMSISGDTSTAEKAADPAAPDVLAAIQDCVDQACHDTCTGPLQLRFRGLGTFGHGRVLFARCITEAHFTTLDTLVRRIRRDVGLGLGVDMKGNPNDSYVPHVTVAKLRPSQIGEFGRQLPMSMWAAHQHHDFGDVTFNRVDLCSMKGQGKDGYYHVVSSVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SGX3</accession>
    <name>A0A088SGX3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_321770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701862.1">
        <property type="nucleotide sequence ID" value="XM_010703560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SGX3"/>
    <dbReference type="GeneID" id="22577918"/>
    <dbReference type="KEGG" id="lpan:LPMP_321770"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320023300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_321770"/>
    <dbReference type="eggNOG" id="ENOG502S8GK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="262225at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO01062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="136" mass="15685" checksum="3AAA27111D00C26B" modified="2014-11-26" version="1">MAGPRDTESMQLETVANGYDTGVLTMPSEEFASLHLQPLQDDTWIRHAPIVHMDNFVQTATGERVKQEILKDYTEAKERLGTNRPDPILEGMMYQAQFMEAYRKDAHTVDADKAHSYRRQLLENHRRARTIKNAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SJ17</accession>
    <name>A0A088SJ17_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Calcium motive p-type ATPase, putative</fullName>
            <ecNumber evidence="12">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_341910</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="12"/>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702617.1">
        <property type="nucleotide sequence ID" value="XM_010704315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SJ17"/>
    <dbReference type="GeneID" id="22578696"/>
    <dbReference type="KEGG" id="lpan:LPMP_341910"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340025100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_341910"/>
    <dbReference type="eggNOG" id="KOG0202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="116380at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098662">
        <property type="term" value="P:inorganic cation transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000123">
        <property type="entry name" value="Calcium motive P-type ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000016">
        <property type="entry name" value="Calcium-transporting P-type ATPase putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="880"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="921"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="960"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="995"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="11">
        <location>
            <begin position="78"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIO01817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1104" mass="121826" checksum="AB4DFC48E635DC6D" modified="2014-11-26" version="1">MNKPASIFTDMAVKGLEDLDDSDVFPVFSGEVVNAGALGNGAKSGTAEVVGVKEHYAMNFGDEQGDEPTPVTYDPRDKFWALSLENVFSLVQLEYPLSGIDATDAPRRAKDLGDNIIPIKGGPSWIIILASQFKNAITIVLLIVIIISGVFKDWAEFGVVLFILFFNALLGFYQEYGAEKSLASLKQMTAGVAKVMRNGVPEIIFIDEVVVGDVIVLEQGASVPADCRIFESNGLEVDEALLTGEALPVVKHANVIRDPDNRLALGDRKNMVYRNTQVTQGRGKAVVVAGGLNTEMGKLAKRLDDGKGSGKTALMRKLDYMMYFLFFCCGIAALVVFAANKMRYTPATLSYATAVAIAILPESLCAVITVAMTFSVKRMAQQKCIVRKLPVLEVLGNVTDICSDKTGTLTENKMVVKKAVIGLDDVYSVGGAPYEIHGDFFPAIRNGQEQKPVSMAQMQEVRYIYEFLKCAALCSTTILHISEEDMDSLTGNGNPTEIAIQVMTWKAGLNRDKLEEEGLECITEYAFDSKIKRMSTAWENKEKCEVYLCTKGAPERIVELCTYRIDEDGKLVGLTQQDRERVDQHICDLAAQGLRTICFAYREDATKAFPIPTDEPFIDAYDRDQVERDLVFLGIVGIYDPPRPESRPSVIACQHAGIRVRMLTGDHTSTAGSIASMLNIIRRRDLDDPVKLQAGPDFDKIDPDVIDGWADLPVVIGRCSPESKVKMIESLHRRKKVVAMTGDGFNDSPSIKIADIGCAMGSGVDVTKGVADLVITDDNFSTIVKAVAEGRRISQCIRKFVVHLLSSNVAEVIALICGLPISHGGESVFILSPIEILWLNMFTSAPPATGLSLDKATDDILQVPPNTEGFFTIELITDTLVYGFWLGAMTLCGFAVVLYGFKSGPMGTDCNRHSGVGCENIWTARSTAFGILYFGLLIHSYTVRHPRVSIFRMRWLDNKWIYGSCLMGTALFIPIVYVNAIAHKLFVHAMITWEWGVIVVSVIIFVAICELYKVIKNLIFPINKVLVEVDEEDVEDVEEQRQREYNTFTRTMPDSRSVERIANENLRMSFASLAGSVATASTGSFRIPTQHQKKQRTFLFRKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SKB6</accession>
    <name>A0A088SKB6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MGT2 magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_351200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02257.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703057.1">
        <property type="nucleotide sequence ID" value="XM_010704755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SKB6"/>
    <dbReference type="GeneID" id="22579149"/>
    <dbReference type="KEGG" id="lpan:LPMP_351200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350017600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_351200"/>
    <dbReference type="eggNOG" id="ENOG502RG7S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271644at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF92">
        <property type="entry name" value="CATION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO02257.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="641" mass="71894" checksum="B5A5BDE312C34DCA" modified="2026-01-28" version="2">MKSRRFQANPDEAVDPLPFDYTLLSHLYVHSDGTDVIDFSGLAVGKESHCRVHSLLKNRSFVPGMMEAEPEAVGSYLHLRVDEDGGSTLDGSGDYKIHGARRPDPPRGVSAPASNLVRIEDRAEHWWFVCQAAEDTALYARLFNGTEDLLRYLKQHKLHLPTGLNSESGTANEAWAPPKPHHDSSNSVSDTTEPVLPLAKWLDIQVDRSNPLSVERVTQLLNHLPISQETKESCLYLSTVDSIDINSQNTGSVSDSMSGYVFLNLLCTPVVENGGRRTTTSTATTAREAGNTGSTSNQKGFLHRLCGFKFDFLRTDKRRTTKRLKIPRRAAAHVSPHGIPPTTQSVMEMRFEAARIKAPRSSVPDPVAVAVIVFADWMITIHEKPFAEMDDMLRMLQLHCSPPEVTTSHLGYTARLSSSMRRRFTAPFAMSMLLQIVVGHHLDSITLAQAVDELGDCVFDVREKQEDQDAVLQHITAVRRCFGECGTDTVRREVLFASLLQPIFADRFFVADPAIRHELENAQAHLWHFQREISDCRDTLALSNWHHNVAIQWLLLRRGNRALRMALLLTEMTNIMQPIVIVQTLYSMNVPLPFEAEGNPPQTTLAPFFFLAAIFLIYCTFTIGAIRHIIVRKSFQTRLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SLB6</accession>
    <name>A0A088SLB6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Elongation factor-2 kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_354650</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703397.1">
        <property type="nucleotide sequence ID" value="XM_010705095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SLB6"/>
    <dbReference type="GeneID" id="22579493"/>
    <dbReference type="KEGG" id="lpan:LPMP_354650"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350054800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_354650"/>
    <dbReference type="eggNOG" id="ENOG502S8WU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="301415at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031037">
        <property type="term" value="P:myosin II filament disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903013">
        <property type="term" value="P:response to differentiation-inducing factor 1"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04515">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.200.10">
        <property type="entry name" value="MHCK/EF2 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004166">
        <property type="entry name" value="a-kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051852">
        <property type="entry name" value="Alpha-type_PK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45992:SF2">
        <property type="entry name" value="EUKARYOTIC ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45992">
        <property type="entry name" value="EUKARYOTIC ELONGATION FACTOR 2 KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02816">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00811">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51158">
        <property type="entry name" value="ALPHA_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Alpha-type protein kinase" evidence="6">
        <location>
            <begin position="25"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO02597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="339" mass="38720" checksum="06B7481FD0146349" modified="2014-11-26" version="1">MSTNEIPEHLPTDEPDVLVPVHKYVYDVKACAWKGVDTMVRVLHPNRGVSQGTMRVCFALEELDETGFCSHMVAKMFRHNISHVVESDYFNEGEAQCICGILAEKFNKVQVPKNFQRHVLSFLQCETVRIKPTEMPAAYQHKRLGFFSYRTTDSGDLLFTMEPRLEGNFTKYTSNFGGVYKGFEKRLSAEEEKKRHRILMAVEAFSHFTLVESGGSMLVCDLQGVNDFLTDPQIHTEDGKGLGMGNMGQEGIDKWIEAHVCNEVCRAMQLKPLSKTLKNFLRTTENESRVSYYQVLRTMVRSQVPMQHEDIIPLSKPLSEMSDEEQLEYAMRLSALLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4I7</accession>
    <name>A0AC62A4I7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3120030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="XUY36695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="614" mass="66925" checksum="FEB9744CBDF4A980" modified="2026-01-28" version="1">MSSQPPVKPPHHHRTRQREEFPDRISSHSGVALDSPRKSVTMVGVTSTTSLPAEARRARQRFQRSSHSHPRRTGCLGVLQCIRDGVIKAVCTIIPPGGILSAAFNMASASIGAGILGLPSATDSAGLILAILYLIVITYFSVFSMYILALAAQNTRIKSFEGMARWLFPAGKYAFSYWAAFIRWFYGFSGCVAYVISAGNSLAPMFAGAAKQHPDNSAIQFFATTQGNRVLTVIIWLCVMLPLLIPKHVDSLRYASALAVMFIVYFVIMAVVHSIRHGLPETSKHIRLSGNQVDDDKLEHNTVFLFRTGNSVIYTVGIFMFAYVCQINAYEVFWDFRPEIRTAKNYTLAAFIGMMMCGTLYLLVAVFGYLDFGSKNLLGKSLLLMFNPFEEVDIMIAYVGIMVKLCVAYALLGIAARNSLYYLIGFQHRYRNRPAAAVAGAAEELGAVDGCAAATAQCSANPVVAMTDIAVVQSGGLVGADNNHGPAEATKDRNSSPSLNEDSVDEEYVDNTTEDTTYVDNIPFWQHLLVVLALSVASLLCGLFIPNINTVFGFAGAISGGFISFVFPALFIMYSGSFTVAQVGWFTYLNTYLLLICGVVGIVFGTIGTIYMTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A520</accession>
    <name>A0AC62A520_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histone H2A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2120030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="XUY36873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="132" mass="14424" checksum="05811436552A02AD" modified="2026-01-28" version="1">MATPRSAKKASRKSDSRPTPAILLFPRGLIGRFLRRGQYARRVSASGAVYMAAVMEYLTAELLEMSVKAAAQSPKKPRRLTPRIMMTAVRHDEDLNSLLKHVTLARSGVVPSLHKAITKKKGGKKSKATPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A586</accession>
    <name>A0AC62A586_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Heat-shock protein hsp70, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2820170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="XUY36933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="654" mass="71302" checksum="17158A359508D667" modified="2026-01-28" version="1">MTFEGAIGIDLGTTYSCVGVWQNERVEIIANDQGNRTTPSYVAFTDSERLIGDAAKNQVAMNPHNTVFDAKRLIGRKYGDPVVQADMKHWPFKVKTKGDDKPVISVQYCNEEKIFTPEEISSMVLLKMKETAEAYLGKQVKKAVVTVPAYFNDSQRQATKDAGTIAGLEVLRIINEPTAAAIAYGLDKGDDGKERNVLIFDLGGGTFDVTLLTIDGGIFEVKATNGDTHLGGEDFDNRLVTFFTEEFKRKNKGKDLSSSHRALRRLRTACERAKRTLSSATQATIEIDALFDNVDFQANITRARFEELCGDLFRSTMQPVERVLQDAKMDKRSVHDVVLVGGSTRIPKVQSLVSDFFGGKELNKSINPDEAVAYGAAVQAFILTGGKSKQTEGLLLLDVTPLTLGIETAGGVMTALIKRNTTIPTKKSQIFSTYADNQPGVHIQVFEGERAMTKDCHLLGTFDLSGIPPAPRGVPQIEVTFDLDANGILNVSAEEKGTGKRNHITITNDKGRLSKDEIERMVNDASKYEQADKMQRERVEAKNGLENYAYSMKNTIADTNVSGKLEESDRTALNSAIDAALEWLNSNQEASKEEYEHRQKELESTCNPIMTKMYQSMGGGAGGMPGGMPDMSGMGAGAGPAAGASSGPKVEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5I1</accession>
    <name>A0AC62A5I1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histone H3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1620290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="XUY37040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="66" mass="7238" checksum="D87F239EB5F19D1A" modified="2026-01-28" version="1">MPCARCRACRRRGGPALPEQRDPGDPGGVRCVADGCHEPGQHPREACVTVRPKDVQLAVRLRGERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5L4</accession>
    <name>A0AC62A5L4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Paraflagellar rod protein 2C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1620770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="XUY37088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="594" mass="68229" checksum="A432368CE3C3BAEC" modified="2026-01-28" version="1">MSSAADMKYAVADVPEVSDITLEAARKQKIHNLKLKTACLSNEEFIQDLHVSDWSETQKQKLGAAHEKAAELLAAVESGTKWALTEAYDVQKLMRVCGLEMSVRELYKPEDKPQFMEIVALKKTLNELKQHPNKTRTVSLTGTIDSGAVKLEKAEEELRQSQLDASDLAKVPVPVVKSLEDCMNVTVVQNALQGNEEQIAAQLAAIEKACEIRNVAIADGEMAIAEEQYYIKAQLLEDLVELVADKFRIIGQTEDENRGFEQIAGTQKRAFQETATLKDAKRRLKGRCEDDLHSLHDAIQKADLEDAEALKRYATQKEKSEQLMAENVERQSEAWRKIQELERALQRLGTERFEEVKRRIEENDREERRRVEYQQFLDVCGQHKKLLELSVYNCDLALRCTGMVEELVAESCSAIKSRHDKIGEELAELRLQVHQEYLEAFRRLYKTLGQLVYKKEKRLEEIDRQIRTTHIQLEFAIETFDPNAKKHSDTKKELYKLRAQVEEELEMLKDKMAQSLEMFAPTEDALHQAGIEFVHPAEEVEDGNLSRRSKIVEYRAHLAKQEEVKIAAEREELKRAKVLQSQQYRGKTVHQITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5Y6</accession>
    <name>A0AC62A5Y6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amastin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2020430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="218" mass="24256" checksum="CCC1F440C593F04A" modified="2026-01-28" version="1">MEWNVPILIYAIVQFIAFVLVLFGTPIDMYRFRPRFITPDTTVTTLWGVKKGGFNSTNVISSDYLWRRCIVRRDRFRLAQAFAVISIFVYGAAAALGFIMLYCCSFFRMVCLALNIVGAVTLCIVWAAVAVTYHIEDNEFCRKESVFSTYGAGFVLLLLAWLLDLFNIVVLLLPISIAAGGAGGSSSKDSKKQDESSNDHSRESSMEGSRQNDLSEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5Z7</accession>
    <name>A0AC62A5Z7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP dependent DEAD-box helicase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">RH</name>
        <name evidence="1" type="ORF">LPMP_2020620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="775" mass="86773" checksum="5D73E95E96C78E63" modified="2026-01-28" version="1">MPRLAATRNWLLRRYTASCTHCLSAFSYLVITTRSVVQSNMMGGPRSLLDQFETRELVTRLRRNRNGNYYRFRQKLWPSQEALEKAVTTMTYSPVGRQPLALLPQREAPRQVFACEGRGGSMLLEAVETEERGASALQSSPASAAVPLLRSQSESGVDSDSLDFMEEVLRADQSVSSKIMTEADVRGTVLGSASTRARQILAGDLTCNPVTASHSTSIFLRRPAESTDAAGISWSALGLDAPISSAAEQLYGPVPTRLQTRLLSALLHEDDNDVLFNGVTGSGKTSALVLALLQGIRSEAAGMNVLVATNTMNAMRLHDTVKALCRRAGGGVVVDRPADDYSWLFLGTYREDHESYYRQLRRGLRCSTGPARLVITTADVMCQLLFEKKMEFEDFGYLRRVYVDDVGAQVPMLPESVPVEVVRERLRNPLAAELLLGTLHQLPGPHIRSVLQLALVSADVDGKLKDHLQGLCMKPVAQTTVLSAVRVPSAVHCLFSFFLGHKEDRFTYLVRVLWNARETIPGRAVLFVPDAEDVLSARRRLRGLGVDARLFSEVYGGNEFKADWKFLLLRESEAFGVDLPLVSHVFINFAPTSWQSFLHMCGRTGRMGNVGWVYVVSDKQEAKRVRQVAEALSVDFCNHVIHEDLQQVLPAHVERFTKQPELYGLDPQFAVRQHYTMQAESPDMAYRKREFFSKPAIKQFQMEDHTSIPLKQRRFDHARQLSQDVARNPSLVLDMQKQGLLDAQLKPTKKLKRCTDVTTNRHAPDPFQKGQRRCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6A8</accession>
    <name>A0AC62A6A8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Kinesin, putative</fullName>
            <ecNumber evidence="1">5.6.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_190660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.6.1.3" evidence="1"/>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="XUY37126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1107" mass="125424" checksum="991ED5D4AA99437E" modified="2026-01-28" version="1">MLAPLSARSTSRRASFAESLSARRASSSAHSARPHLTSVPRSQRSDSICATPTRYRSEVSASARQLRNDVYESPATTKANAMKVYIRVRPFSEREIAQKVTPHSTVRIDAENPCVITILEPARAFRPLSTHIFNCCFWSVFENAKDGVEGGQSDIRNGVDTFLNGGMNSARRSRAQSMMNLSSLPQSACRATRSGLGLDIEGMEASGETPAYDGAGSAPVMVDANVSHPPYAGQDQVYAHVGKPIVGNTLDGYNGCVFAYGQTGSGKTFTMLGYAPSTSDIRARKGSLVSAASTESSTPLDGAVEPFESDDGDDVVDKTGLDPNELQGIIPRACMDLFDGLRAKRAKDSDFTYRVEVSYYEIYNEKVFDLIRPQRNTDLRIRNSPNSGPFIEGLTWKMVSREEDVARVIRKGMQERHTAATKFNDRSSRSHAILTFNIVQLSMDDSDNAFQMRSKLNLVDLAGSERTGAAGAEGDEFHDGVKINQSLTVLGRVIDRLADLSQNKGGGLSIPYRDSNLTWVLSDSIGGNSQTSMVATISPHSINFDEMRQTIRYASRAKNIINWVKKNEDPQVVQLRELRAQVADLELRLKEAGGSNYTNEYVRGLEKKLHLAEKKCDEQERIIAGLRAQLEFAGVADPTLAEGYLDPTTRAKEDQQRAKREENLRKQLDKAQMTVAELKAELERRVATIESESLKAMREALQRQEARLAVVATGVSLYHRVLPHFDDIDIVMALVREKETLLQRACEDILDTNTESAAALEKMLREREHDLRETKRLHEEKLAAQAERFCTRLKEASDENAAQQQQLLDRHRDAIAQLEERLQRSREISEIELKRNEEEKEQLKQRMQVAQERMRHEYQQEIERLRARLDGDIGDRHKSVDAVRQLQEMHEREAARLKDEMDHLRRSRDSDCARLQNQLENERLRRESDLMEKDRQARLVRNEVDDAKRAIDKLNDEKGKMEKEYQDQIRGLMQQQEQLVTASNAVLSGWESKSSELEADLHKLRALLYDRDYMHFRQKIREMAFMDRSDFDQKLQELDEKERLQAARINQIISKARRAYDEQSRSLKRFERDIKDRIDRAKATDGSNNSTPRPEGTPPPHNHIDPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6G4</accession>
    <name>A0AC62A6G4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2021270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1262" mass="130942" checksum="13B4BDF2100D0AC1" modified="2026-01-28" version="1">MEAPAERAPPVRTRRFTAATTNGTPTSLSLSMTSSFPVHHTAHMSACAATGRTSRNLDPSQQPPLLRRLSPSYTRSPYASPVTVHEGAATSSSAPLDDVSCLPLDVLEPAAARWALTADRGSRRAPRVRSSLGPQSDVVDTGLFVCPNTVVAALYSAAPGRGHLVMTAESGGWLRVREQKTGAIRHQRQLRDGGEVSCLAWASAGGDTAVEPLGAVVVAGQLSGLISFYALVGESLVELPFATCVFHEAPLLSCLPLRAPASAEEPAATAPGALVNVLLSLDADGVVALWSLQLTEMGGGADRGNEAELRLSALLLDCRYAFLSPTSSFPPVVMAAMGLSCVSTSTCCVLSTHRFVQQPLSPTGVPSDGDEEADTQGSAVVFLSSFTVSLTADPNATMLSINTGASTGLEEGAPTPDSAQPPLRRDWKVLRAYRVPVGLLPQRSDEGSSTSVNSAVVAITALCVTGCISHSGSAAPAEQLWAGTADGRLLIWEAHTGRFVRSLHSASAAPVHSLTSVPSPGSPGQALVWASQADGSVMAWSADTYTVAEVLPVSYPPSGPVVSRTGDAEDSVGGDPANVVVTVRDAVDLLRATRHRCAPSTLRAPWRRGCGFTLFVKPMELVCMQRAWSVGTDGTVRTWLLPSGRASAGGAVADTAGAAVASWPTSDTGGAARAASLDAHTVRCYLQDRADALARERQAQRLASEAQQEQLQILQERNRVLAAALQQAIRRLEQVSVDDLVRSASRPCSSPSVAPLQNEDGADAALVESAVLAPGSPTTTSTTTLSAVSEADEQPVVAAQLSTIVVTPDATSPPLPAMTTLPPAAQMHVQALQQLLEELHAKLEESWSRNDALREELLECQLRTLGREEDIAQSALMTAADEVAAAAATGNAEGQTSAAHGVTAATATTSAPSPVLPSAHIATSSLSGSTNGSYTQEEGRAHSDRLQTSPPPQTRHAPYTALTASADNSFPSSAFCSPSVEELAPWAVAQARPLTPPPPPEMRSTEDASYPLSVKPQVTPPSPTEVSPSTSTAAERFFKAASAMLRTSTITYGDVARREPSVAGRAHVPTPPLLSETEEEEDVYAEEGDYTDGDDDEIALLEAWCTSEGDLSPIPGPDPVAARGATSTDASVVRGGRGEPLPSPLSLFMSTSFSAGHATGGSGSAIDRPGALRVAWPPTHVTATWTTPARAAGRDDPVVDNARGRVLTAPSRRSGSLAAGSARPAAVGTGVVQSAPMQGAGTTPSAASPPYAFRSPIIYRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RGV7</accession>
    <name>A0A088RGV7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BSD domain-containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_010070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009370">
        <property type="protein sequence ID" value="AIN95108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696650.1">
        <property type="nucleotide sequence ID" value="XM_010698348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RGV7"/>
    <dbReference type="GeneID" id="22571736"/>
    <dbReference type="KEGG" id="lpan:LPMP_010070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000031400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_010070"/>
    <dbReference type="eggNOG" id="ENOG502RYZ9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="BSD_domain-containing"/>
    </dbReference>
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        <property type="entry name" value="BSD DOMAIN-CONTAINING PROTEIN 1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019">
        <property type="entry name" value="SYNAPSE-ASSOCIATED PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="BSD domain-like"/>
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    </dbReference>
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    </dbReference>
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            <begin position="340"/>
            <end position="391"/>
        </location>
    </feature>
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        <location>
            <begin position="256"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="575"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="616" mass="65750" checksum="1693C5E5F191CE5B" modified="2014-11-26" version="1">MSSAEFVRNVGAHTTIYRWEASGLEDLNRQNKLSSLPFWIPNSTTRRHQFKVVLLRGLMLSASPATDPFGVLVEFIPPPPPPVVAASGSATSTAVSSSSPPSDFPGGCAVTCEVLPIDSTTPTAEGEGQCRRDDGAEAAQRKAITSTKMAVLNASNAQVSFPEFVSADVLHNPRYVRGAPKSFTLQITIETDINVPLHQAATTAFSLFSSLTTSVSHLLDSTAQLYHEGRESINGTIFAPTASALAHSSELWHGMTPSSSATAASGPTAPMTAAASTAATLPPWEQPPEEWRDRAAEWRSLVSERLAGLDGTYRHGVEKTLSPDEVGLLAEVGLMETDLWALYGLFDFDHDVQEGLLASAEVRAHRYRLVPARLKEETFWANYFWKVHCVGQCVTERQVAAVLVALCMPERAAQTKHSTTLEVLRHILDGEEVVAVLEDFIKRGEAAEPWCTVAAETARHYRDVLDVTSQRTDLAPNIHTQLGSTLSSLEEALSWYSDALAGTADPHAVSVDGDACAAAAAAAVATAKTVADEVAVNVADAALPASPQVVEADALSKQLWQEPSPEASPAPATPPAVKSATSSPHTSTSGGLPSASRVEFAKMPWEEEDEAEEPVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RH10</accession>
    <name>A0A088RH10_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_030230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009372">
        <property type="protein sequence ID" value="AIN95257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700965.1">
        <property type="nucleotide sequence ID" value="XM_010702663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RH10"/>
    <dbReference type="GeneID" id="22571889"/>
    <dbReference type="KEGG" id="lpan:LPMP_030230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_030007100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_030230"/>
    <dbReference type="eggNOG" id="ENOG502S1HJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271441at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="155" mass="17352" checksum="0C62675A8252E416" modified="2014-11-26" version="1">MLRRTARCAMGNSRFSGSKERDRIEQERRRHVLYDAAGNLQIGGLLLLMYDDFKKPAAVGLAIAVFLYGYNRLLVHLSREEEAEGLRLDVQSEAVARQTGKLKADRYLVKPNRQIDDPDFFNIPALGGKGVNSSRLLSDDSVSSGTLHSERNRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHS5</accession>
    <name>A0A088RHS5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_050850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="AIN95527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703849.1">
        <property type="nucleotide sequence ID" value="XM_010705547.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22572163"/>
    <dbReference type="KEGG" id="lpan:LPMP_050850"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_050013200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_050850"/>
    <dbReference type="eggNOG" id="ENOG502S9UV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273921at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="881"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="922"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="997"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1053"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1119"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1247"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1572"/>
            <end position="1628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1692"/>
            <end position="1754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1787"/>
            <end position="1821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="404"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="585"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="679"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="723"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="761"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="997"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1010"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1053"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1064"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1122"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1142"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1275"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1347"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1383"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1407"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1572"/>
            <end position="1586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1589"/>
            <end position="1598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1606"/>
            <end position="1623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1806"/>
            <end position="1815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1821" mass="193199" checksum="37411BFB3365CB6C" modified="2014-11-26" version="1">MLSFRDIARTPDDADVLQTSLEELHRRRHAKQQQQQERERERQQREENPLLDEDAYSWSVADELSYRREVLNTWARQYPKLREAVASVGTVVSPRNAASWGTADTTPAAKAAPVFSVVDVVRPLYPSLWRIPAGTIPANFYTHSAATVAVKDHSTHSCLVRVRWEAIRAMDPSGSIPHAQPQPQRVLARWPQGKPVSAKVAAVLRSIGIEKRNCEQCGKNVRWRQQQDEEEASQRQPDYRAWDHHSAVSAKLFGNRASSADSAKSAIKVVAVNKPDSRVMAVSAGVEDDGSSGGGSTADASESALGHELYWPAHITRIRALFMGAAYLQDTFHGLSQLQQYERFEPVLASALVSPLRIVVDVVYAIDETSEALGLSIDPFVQVDTTTSLKACKDAPTSRDCDGLRSTSLDSRSDSITPSRGSMAARRGTLSPREALVAVVEDECPVLLPSSLPPVLSDLNYGFMATSTTAGTAAGGSGSAESQRVASQRMSLTDDPITANAAALCRSTLSTSPLPLYTILAGPVTQTHSIVLLRPTPDVVCTARARALEELEQRWRRLRQALAGRLVTYEEQAPTVAVVQSSAQATSPAPVLTTPPAATTTPSESLSQRRSLSPSAILTVELPDVDTYVSPLIDCSPQQDEGLPAKPAGAMSVMKGEMQYSTRVPQLQGGRLPRQPLTHRVDSAHDVYGRRPQLSFTSLRPSPADTDLCSAEHGAHNSKSRARSQPSRASQSPRGSGARDDGTWAAAAAPWSVPTPPKSPLPSQLSPSTPRQTRTPRADQGASSKDDDTTAAAAPHRDAMTARTPQWARAPVSPTSVCSLASTDGLDAPYNNVPFSSTEGLRSALPPHGRRAETEESRVISAAVRSAGEWLRLRQAVARAQRQPAASPQPHLPTLTIEPRSPMSSDAFRLANNTGRVSTAAATDFLDKAPPSSAFLPPRRRSHDGDDSPHHRRRSEMESCLVVIASSRTVPEGQPMTALQEACVKPHLSLDVHHTISDSAHQQSSTGRDGGGERVSPRSGRDGEAPPTLLQLHSRVSKGGTLIIPHLSTCDAASTPTMHSSTPSIPPSPPPHAASPSTRMNISAGATAQPHAEDNGQPLFSVRHTIRQQSRILLYHPDAASSRGSTTYTSAQPSATPPPVLSSESPLQRSPTASSTMRESCGASDEPRSALTHISQPGTVALVGCKGNEKAPTAPQAACATASASSSSGDDPPMLSGTAAYPSNILMGPLFAAAAVQRASASRRAGAVASSSPLPTQAAARESHSDPALTSGPQLSSLPASSAAVAAPRAHVHSVSSLPQQKDDAAASSNDRNHTCGAAPVTSPSSGAAVEKADPQRPRRQTPPLQSNTNVVGATTASVNHQVAQGGSSHTSDAVTSAESPLPRRPQSPAPPSVAGGNHDTHEAASISASPSSVKPQPSAVHADVTSAASRARGDPRLSSRFGVSSSSRKDHRHALPEAPKTETPPSTDGDAGDSLRRHQQQQQHAGLVSVEVSRDVLSESGNREVELPEQPVRVSGGLTSCSTPQLQNPYVITANASVAAPVSSCELETNLESLNQPVHSSWEELPAAHRQATNAIPSRTASTDVRSSKRSAHPRHHPPSDAVQASATSSSSPTLSASALPLPKNPRPAQCRLWRMQSMIVGSTGNEKLDRVDPVAPVPCRRHTAPPLATSSASWAFSDPSISLLSSWVASSRGTSPAPQASSHSSRSSRGGEGRTLVARSHQRTSSSQSGRQHHHDVITLSQSPSTTRRHRVLVRRVVRRHRSEVFVEEGGTLVYRAPMVASHHLRSDEGSGNGENDTAAPLLLSSSLDTRAASSHRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHW6</accession>
    <name>A0A088RHW6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinetoplast-associated protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_050510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="AIN95493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703815.1">
        <property type="nucleotide sequence ID" value="XM_010705513.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22572129"/>
    <dbReference type="KEGG" id="lpan:LPMP_050510"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_050009800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_050510"/>
    <dbReference type="eggNOG" id="ENOG502SJFE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267969at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="950"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1035"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1086"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1128"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1312"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1337"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1472"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1662"/>
            <end position="1734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1777"/>
            <end position="1806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="395"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="396"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="589"/>
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            <begin position="1039"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="1097"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1316"/>
            <end position="1327"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1488"/>
            <end position="1498"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2066" mass="216303" checksum="096634AD130A70C3" modified="2014-11-26" version="1">MSSLSSVVVGPRGSHNVPIEPTQALTMAAMSLSPPLQPSSPSSRLLQEIEETCKLLRTFRSLKERGASRAELADLHTRVKALKAAQQYQQQRDASGYTEVTLPLPTSATSDAAAVAHPSLVRPPGVSLSSAGAHRHAGIALHKGAPGWTAGSSHSSYPPQQQRQRGVEETPATHRDRRLPEGRHHHHRHRHHDARVDQAALSPISTGLLTTAVQAPTAVCSGAGNAVGSGSAGDRSAVARHPRAASPVAASLVRLNSMVFAITLAEAHTRREIAHRWERRWLRHWGNFKEGRIAIALRPPTGAVAALPPPQLQPERWAEAAPMALPSERQQRHQAGLTVATATEGSRITTTTTAHHIVASSAPVQGWRIGEAFTATTSRLVAEDPPQTSSLSASHRGNDEGHRVAHRQEQTTPEVDTSALEGDEVVGITPPPQPHQQPTASVTAQYSEANSRAAADAAAAEEAAAARALATQLAEAQAAAAEAEKTRLGKKAAERLAAAVRNVEDDEAAARTGTEWAAAEARECVKLAEVAARRRAEKAREAVQSLVAAEARARATLEADEAHLMVSHVSAAAETKSRQRAQGAATREAAAKREEEEERKAAAHRAAEAQRQAAADSEAAERRSVEQQWQAAICLSESLLAGWIKNAVAAAPQWTYSKGKRVSEWPTCNESAMEDAQSREAAEAQTRLCEWQQAAERSVAASSAAADAVLEEWVSAAATEAIARQCQAEQAARTEVVWANNEDSVALVASEEEAWQQLLQQHAADVEATHLVVRAAEEEAAARLKEMKVAKEAARTKAFEEAARLQAQQEVTAMADTLFSAVTELSKIIVDGCLAEAAEQTWNRAGVEELQMQQREGIKDKEVLTRDDMYGDALDELRGLREEEAAAEVCKRIEVEAVSTTTELAREQQMRGQAAAPCLYLSELSEALLHEFLHDAVATAVATRAAAVANDRSVEAPPPAALPEEEEGTTRAAMEDEQEQQYHQPSPGDATDEPDTLTEKAYSNSVDSPDKATVGTAAAAPEPVVVAASVPLSPLSSADTTRSAVTATGVSQEHAKERAGLPSPTAFTRIVDDLLSGVLRDAATEARKGGGDAGGTVNMTVTSPTHAVQRTGRHRVAMLDQSDASFASVDSDGSYASSGRTPPQVLQPKPLALPPTVIVSGAADDRGPQVQPTGGELSDGTGTNVADGTVSFAASPAEVSNADKHSPHRCIVSPLLMPSVSVAITNTTATTLTASAVGGKGKGRVGGAASAIPTMPSSSSHCFSTASSADDDDDDVAYSSLTATGAPLPLILQHHNILFPLLSQRHGGSIDDESCAATTPAGSGAASDTPTAVALDIRSSSSEKSRERQQLQGSAAIGNRDATSDADVRLSAGLMMDRRTMGMTEDLCAFQLDAPLPLPPQPYGMTGHCAGANVPRGDSLSADAVAAVATSLVQSMVYEATLLVASRGQLTKPNTDSDREMSCGTVKVHHTAAPPSLFSSAERHKQNTSEGKSSHNGISAFTSSSATCNSDGVSSFTRVGDDEAHAEEEANLAEISVGLTRADAREATLRVVRSSLPTVAAEGIAGAQAPLTSLPTLVSAVAAPNDFVARLRQPRTEKEAVEHQQNRYLTSRELALVSARYLTSEAAAACVMDVGSTATLSTCAVALALSVGLVRAATLANRHARRRVEEEAGKSDSSSTGTGGGGVLAGEKGSHKLTRGGEAALAVTDSPDTPPPSMGADDADGGAFSTGIIGEAGGGGGDLGMFGPTSPSAVGNAAQARSSWAFPSHSPVAPVLPLSSESGKAEDTDMSDGTMALGIRSPSLQSSPSYRLVSKFTAVDDVKGALATNSAQQQTGVLDKLPAEWAAALRGVAERVARDFMHYASRRVLLGQVEGQWNQAHLHTARRIHSDAIAGVNVHALFTQELQLRDVALLVYYYVELATNGPRERVEPCCVPAAHGEHNIFGRRSNGAVGDDNGVAAIGSVSNASRKDVTGFSHFNAASTAVLAPPTQLQPPSAFSRPLPQRSSNLLSATTAIHVRRAGLLHLVLEQCVSNVLNDLVGDTVGWLGTACLHAAPSGAALNGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RI92</accession>
    <name>A0A088RI92_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA 4-demethylwyosine synthase (AdoMet-dependent)</fullName>
            <ecNumber evidence="4">4.1.3.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">LPMP_050730</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:36347"/>
            <dbReference type="Rhea" id="RHEA-COMP:10164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10165"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64315"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="EC" id="4.1.3.44"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification; wybutosine-tRNA(Phe) biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TYW1 family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.44" evidence="4"/>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="AIN95515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703837.1">
        <property type="nucleotide sequence ID" value="XM_010705535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RI92"/>
    <dbReference type="GeneID" id="22572151"/>
    <dbReference type="KEGG" id="lpan:LPMP_050730"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_050011900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_050730"/>
    <dbReference type="eggNOG" id="KOG1160">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271553at2759"/>
    <dbReference type="UniPathway" id="UPA00375"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102521">
        <property type="term" value="F:tRNA-4-demethylwyosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000196">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013917">
        <property type="entry name" value="tRNA_wybutosine-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034556">
        <property type="entry name" value="tRNA_wybutosine-synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930:SF0">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE TYW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08608">
        <property type="entry name" value="Wyosine_form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00284">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01071">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001838969" description="tRNA 4-demethylwyosine synthase (AdoMet-dependent)" evidence="16">
        <location>
            <begin position="30"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="domain" description="Flavodoxin-like" evidence="17">
        <location>
            <begin position="93"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="18">
        <location>
            <begin position="479"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="56"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="382"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AIN95515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="845" mass="93761" checksum="742926487FCE4D06" modified="2014-11-26" version="1">MMIAFLFQLLVSVGLPLVALLLYNHLADSIHARGSVNVDDVNAFSQRVRAELEQLNVPPALPEAAPGQAAPPPAPMRSSPAVTAPPPPEAAEILIAYATQSQNSLALAHKLFSLITAQLHTAPPSTTDDAVCPLVRVMEMREEEDSSASVAAASAAGGRVSRTNVCRVDTLLEQSQYALIIFIASTYTNGVAPPRSQAFEALLKDSFEDHRIPRNTLARKRFAVFGLGDIAYGEERFNAFAKNLHEWCRGLGAPPFVVPPVYTTEAKTQSLFRIFSTALLKWVSRATFHRDGTVTVKKKSEMGTTGPAAASATGMLSHKAGGITAAPAGETCGSEGASCACQQSTQQQQQQRQPCGNSTGPDGDDNCGCCKTDSIANCVAASKRDDDDEADDDDEEEEVNGENDGMDDVEDLVWDGTEDTDFDINKDPSELPELLYPKLRQNLEKQGYRLVGTHSGVKLCRWTKSMLRGRGGCYKHTFYNINSSQCMEMTPSLACANKCVFCWRHHTNPVSRHFRWKQDPPELLIAQGMAGHYQMIKQMRGVPGVTPERLATAMQIRHCALSLVGEPIMYPQINGFCELLHQHHISSFMVTNAQFPEQLRDLKPVVQLYLSIDAPTPEELKRIDRPLFEDYWERCLSCVKELAKKQQRTVFRLTLVNQYNTENVKAYADLVEMGQPDFIEVKGVTYCGTSTSSTLTMKDNVPRHDEVISFCKALCTEMASRHPHYSTLQMNTEEKGGDDGDDDEVIVIPAEERNRPYHVACEHEHSCCVLIALDKFFFEGHWHTWIDYERFYHLVESGRTDFTSLDYAAVTPAWATYNSKEKGFDPEQTRVVRKNARPTVVTASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIG0</accession>
    <name>A0A088RIG0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_070660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009376">
        <property type="protein sequence ID" value="AIN95752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704074.1">
        <property type="nucleotide sequence ID" value="XM_010705772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIG0"/>
    <dbReference type="GeneID" id="22572401"/>
    <dbReference type="KEGG" id="lpan:LPMP_070660"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_070011800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_070660"/>
    <dbReference type="eggNOG" id="ENOG502SHCF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266875at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="253" mass="26101" checksum="E749BBA9C78DA226" modified="2014-11-26" version="1">MKPIVLSFQIPSMRDACKANARRSSEAAAAARTLVVPYPNGKFTLQISGIHARLGPTKTSACTNSGACKPRQKEQHTERMPSSLSSDSGLAADIVVHAHVCGEVNCAPRSYVVAVIPLRFGGTATPPLSGPAPSSSVPSTSVGTVTLPSAPYDKRVINAQARMAHRGVMAPVFTSAFARLDLRTQVERVRLSFTVVPCGRPAEGGAVANGAAHAHAGKRLREEAGKGAGDAESAAPLDCAIDVTVVGTVSAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIK3</accession>
    <name>A0A088RIK3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_070270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009376">
        <property type="protein sequence ID" value="AIN95713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704035.1">
        <property type="nucleotide sequence ID" value="XM_010705733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIK3"/>
    <dbReference type="GeneID" id="22572362"/>
    <dbReference type="KEGG" id="lpan:LPMP_070270"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_070007600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_070270"/>
    <dbReference type="eggNOG" id="ENOG502S2C1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271558at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="596" mass="66429" checksum="0FDDAF76BEB005F7" modified="2014-11-26" version="1">MLRFTKRLGEHVAMSAGVGFPVYKETRNFFWRQRVRNFRRRGPLGKLATLVGYGAASAGVYVATCLVVRTVHQPTVDALFAPGRDYTLEDWKDVEPTLQPGDVILMRGSGPVSWCITTLQFILSFLKPAALRYSHVAVVVAPAVIEYVSGDKGETSVSTATRHTEAGGAVLSSKASALSAPPYRVSNLSEVFERGAEPAAPGHGRQVPTAPARSVREQLRAEEAMLHSRPVIRRGAVILEAMDNKEFDVVDVKGNVTHDAVQLVEASRRLLSMTPSGVPAYHYFAVRRLHNYDHTPERERRLARFCEESEGRRMDSSLLYPLAFLWPRLHTRMHPLRQLITGEVSCSELIVELYQELGVVERRWRWVPLDPDTTALAPTPSNGAPRQGRARSGEQSGRGVAVPPPPPTLADVTDDRRSRSLHVYDYVYGRLDARAKRPVITRDRPLLPDTSVVESSEVIAAADVRLRSGRARLQLSWEHTDRMAGVASDYDRAVTGDTEEPACRQMKRHARATYHVDAAVPPIVLRAGDTFRGVDDRVYQLQWYYEHSSVATCPYHFAEGAGESMLHFAADLNLGRESPMRIVREEDALSRAVEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIX7</accession>
    <name>A0A088RIX7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Vacuolar transporter chaperone 4 catalytic subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_090210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN95937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704259.1">
        <property type="nucleotide sequence ID" value="XM_010705957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIX7"/>
    <dbReference type="GeneID" id="22572591"/>
    <dbReference type="KEGG" id="lpan:LPMP_090210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090007100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_090210"/>
    <dbReference type="eggNOG" id="KOG1161">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6493944at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07751">
        <property type="entry name" value="PolyPPase_VTC4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.100.30:FF:000003">
        <property type="entry name" value="Vacuolar transporter chaperone 4 catalytic subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="entry name" value="VTC, catalytic tunnel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="748"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="789"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="VTC" evidence="6">
        <location>
            <begin position="212"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN95937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="825" mass="94357" checksum="4F383BBAF02F77BA" modified="2014-11-26" version="1">MPYSKAWRSAIYPDFRDQGAYVDYKATKDILHRMKENIANPSTPDELYASLLSQKMRVYEWCERKQEELLKMSLRLYECSKYLTEEEVLTNWSITLASAPKDKGKRLLPREARLIADAIVHELLRFVECRNLNTDTIEHIIGRMYRYAVLGPTGDRWKNIYVEYDYDQISVEEVFLLLSRVYDCVKQTEERISAKGKLSIPTGSEGSQVFDRRSVKYWVHLQDLPFVIARIIPHLPLSTFKDTYQECKTAGIPFRLFSPVSSVYYDNNKFLLYHRRLERIEGSTLIRMRWYSDTYSEDWNALQEDDNVFMEIKVHHEAWSGERSNKRRFAIKEKEVDAFVHAQLSLLPALEKLKRKNASEEEQEKFKSLATEILSKIHAYDLKPVLRTQCGRAAFQRGADQKVRVSIDTGLHMSAEDFGLDHHWRYTGGDSPVSHFPYAVVEVKLQCTENERIAPWIEELMGCRYMESVPKFSKYAHGIASLYGHTSFISMVPYWIHQLNIDIRASTKPEVHLWDPTMGLAAGCLERTADRLIFGTNPAQTQTVGASEAQFLPRTDYAKIYQRVLRILQHDANRAAESSANASMVAASTTNSVGVVDGVADGKANKSMKEGAQGAEMSATSAGAGGAQLGLFPVVQYPVDRRHMAYTTFHLYPYSESGTEPLCYDPKDGKNAFAQVFYGKIPWQTGKRIKVPQKYDPKTLLTSERYMAKWMQLATEFGLLGLSSIQFGKGLFLPQDVANYSPFWKDNFHVVTGVVMVVIALLTQVYAYVAFKARSRRVYARRKIRYDDVVSPTLLTFFLAVSFVVIAMTHVARRYGPMLTGSDSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJA8</accession>
    <name>A0A088RJA8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_080820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dpy-30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="AIN95890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704212.1">
        <property type="nucleotide sequence ID" value="XM_010705910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJA8"/>
    <dbReference type="GeneID" id="22572544"/>
    <dbReference type="KEGG" id="lpan:LPMP_080820"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_080010900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_080820"/>
    <dbReference type="eggNOG" id="ENOG502RXBT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="432281at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22966">
        <property type="entry name" value="DD_DYDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007858">
        <property type="entry name" value="Dpy-30_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049630">
        <property type="entry name" value="DYDC-like_DD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037856">
        <property type="entry name" value="Sdc1/DPY30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23356:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23356">
        <property type="entry name" value="DPY30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05186">
        <property type="entry name" value="Dpy-30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="321"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="546"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="90"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="416"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="556"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN95890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="569" mass="63262" checksum="20D130CD9011E383" modified="2014-11-26" version="1">MDSAYLKNHVGMLLAKGIAETVTAQPSNPQEYLALYLLHQLQEEERKTTAAAHKRKVNELREEWCQKRALREKSAVDVIQRCFHRFQKRLHTKRVAEEELREMYEAAEAEAEELLDEEAAIKAAKGDEDTEEDGAGAASERHSGSLAAAALEEKETVMSEARSEFFKSQRFLLTLSKSAVGQLKHKLEDEAERVRIAQDITLGAYHRAAAQEAALVEAMTTPSMANAAPALSPAAAELAGRLAEHRDHRFICVPYVNYVAFRCVCYLLLNATPKATNTAAKVAALLKPSVLVQQLRAFNPVAAYDRGVALKLERLVPELSSATGGDEDMDEGNGEGRHKESDALAEEGSSVPFTQPMTRQVRRAARVLRTCWLDGEYQCEVDPEEFYTEEMLEEDSAKAEVDGDENALKQKLIPTLADEIEAAAKARERVAELRSIVEAQVKQRGGIVMYGLLRFVSAAVAYRQARDAVVQQRQEMGLPMDNLDELPEDEAEDPMNDEALIDEETGELDVAGVQVLQERIGVDTEEALAKTWEARDRRQREAYSMKAISLQQQLDASEEDEEEDEGEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJM7</accession>
    <name>A0A088RJM7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Archaic translocase of outer membrane 12 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_100870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696810.1">
        <property type="nucleotide sequence ID" value="XM_010698508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJM7"/>
    <dbReference type="GeneID" id="22572824"/>
    <dbReference type="KEGG" id="lpan:LPMP_100870"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100015200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_100870"/>
    <dbReference type="eggNOG" id="ENOG502SAJU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270044at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN96157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="12033" checksum="C60ABDCBC9EBA719" modified="2014-11-26" version="1">MLFLKGASVKDGGESTVRRLWGFTKSYVKHVGHAYLEFFGPLLLLVAVNMAVETHDNERFGLGWLYCTSLKDDRVREEKFPSYEPCSAAQRRRSEAANAVEYAAATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJU3</accession>
    <name>A0A088RJU3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rrp15p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_050080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="AIN95449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703771.1">
        <property type="nucleotide sequence ID" value="XM_010705469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJU3"/>
    <dbReference type="GeneID" id="22572086"/>
    <dbReference type="KEGG" id="lpan:LPMP_050080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_050005800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_050080"/>
    <dbReference type="eggNOG" id="ENOG502S0UF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20949at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012459">
        <property type="entry name" value="Rrp15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07890">
        <property type="entry name" value="Rrp15p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="21980" checksum="AD99344DC685D190" modified="2014-11-26" version="1">MAGKFRGDVGKLSKTKKSKAAKRAKGKKVVSLVKRSPKLAQATLQSRIAELTSRDSAARASISGSKTGKAAIPLSAAKVQVGKAALEVVGKRKRERVVPEKDAPVQRSTAEAVGLKILHQAVKSQSHGRLLPHQNRHDYEYRLRSVATMGVVQLFNSLAQSRKASTALEAEEMRLTSDKVMGKKQVVSKEVFLAALRQPQQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJZ4</accession>
    <name>A0A088RJZ4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Small nuclear ribonucleoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_050520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="AIN95494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703816.1">
        <property type="nucleotide sequence ID" value="XM_010705514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJZ4"/>
    <dbReference type="GeneID" id="22572130"/>
    <dbReference type="KEGG" id="lpan:LPMP_050520"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_050009900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_050520"/>
    <dbReference type="eggNOG" id="ENOG502SNY9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273834at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="138" mass="14394" checksum="34E90E71C6101BF5" modified="2014-11-26" version="1">MDSSAGRDAGVGPSSSVAKVPGAGTSSSSAPTDPFIYLVQHIHQCVAISLLPADDKDDGAVVRGTLLSVDDLCNVMVQHWSSTDAMKLDCSAGNGRQPPQQQQPRKRARLDAVSGGDVEESVRLIRGAQIVSISLLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RK41</accession>
    <name>A0A088RK41_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_051030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="AIN95544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703866.1">
        <property type="nucleotide sequence ID" value="XM_010705564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RK41"/>
    <dbReference type="GeneID" id="22572181"/>
    <dbReference type="KEGG" id="lpan:LPMP_051030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000033100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_051030"/>
    <dbReference type="eggNOG" id="ENOG502S4YM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275586at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="145" mass="16343" checksum="D054944236BAD8B4" modified="2014-11-26" version="1">MQCTFLKLSARRGGALAPSLFLHADSQQVRVSDAVKRVEAEEFAKNYQMKPMTDHQRSSFEYKSSAKGAEVGARNEAAFMNYEPFTPRTLSGRLVTPGDINLLTVSPLYCALLCITAATWGVFYWDMYCRKNYETVLIARPKAMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RK81</accession>
    <name>A0A088RK81_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_060130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703896.1">
        <property type="nucleotide sequence ID" value="XM_010705594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RK81"/>
    <dbReference type="GeneID" id="22572219"/>
    <dbReference type="KEGG" id="lpan:LPMP_060130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060006600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_060130"/>
    <dbReference type="eggNOG" id="ENOG502S5YM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="242639at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="109" mass="13020" checksum="ED69259B0F2B01AE" modified="2014-11-26" version="1">MLRHSSRLLVRLPKCRRPRERPWEIFNVRDFGYHEGSQNYMMWLGTAVIVTSMLTFEVYQQVQRIFQRGDTCTACEAARAHYRKRVEERGREMEAQTQYSLKLGKEHAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKC2</accession>
    <name>A0A088RKC2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminopeptidase, putative</fullName>
            <ecNumber evidence="2">3.4.11.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_110640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.11.-" evidence="2"/>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696913.1">
        <property type="nucleotide sequence ID" value="XM_010698611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKC2"/>
    <dbReference type="GeneID" id="22572929"/>
    <dbReference type="KEGG" id="lpan:LPMP_110640"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_110010200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_110640"/>
    <dbReference type="eggNOG" id="KOG2597">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="412814at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10590">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041417">
        <property type="entry name" value="NPEPL1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18295">
        <property type="entry name" value="Pdase_M17_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Probable aminopeptidase NPEPL1 N-terminal" evidence="1">
        <location>
            <begin position="46"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="192" mass="20383" checksum="8902EF778771C869" modified="2014-11-26" version="1">MPAMKRLRSESAVEESAVSAYVQTCVKFKSNVTFTDISKVSCVAAHVLLVGALGQLRDSSVESLRFYCPAVAEALRRVKDGATVKTLAVVAGREGYTEVTVTALPATASRTNCPYRADSLSEAVVAACGTVDEGETLDVYVRAPAGAEAAIANAVARALSHSNRVACVTRFHLCEFLFFLVSLLSRDEVFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKW9</accession>
    <name>A0A088RKW9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MINDY4 N-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_080040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="AIN95814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704136.1">
        <property type="nucleotide sequence ID" value="XM_010705834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKW9"/>
    <dbReference type="GeneID" id="22572466"/>
    <dbReference type="KEGG" id="lpan:LPMP_080040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_080005300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_080040"/>
    <dbReference type="eggNOG" id="ENOG502S9ZR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270849at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059022">
        <property type="entry name" value="MINDY4_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26038">
        <property type="entry name" value="Dimer_MINDY4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MINDY4 N-terminal dimerisation" evidence="2">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="229" mass="25276" checksum="53898167916835CB" modified="2014-11-26" version="1">MDLTDNSMWTLVEEAVIEDRGEDEEEVLAQMVRSYLARRGLTDTLAAFDEEHQSYWSSSKHPYKGSPDASKPAASGEVADLTPAADHPNVNYAASLDEASGGMDKRKVAQLLCLQERYEAAAALMAPSSLARIRLLCIQAQSLEDTVAAVFYLATHVAPLVPFCTDPTMGHRVYTAALSNLLSPCRERSSPDAEALAREVNDELCGREQRSSLHVLFNWAYWQETSHTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RL07</accession>
    <name>A0A088RL07_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_080600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="AIN95869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704191.1">
        <property type="nucleotide sequence ID" value="XM_010705889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RL07"/>
    <dbReference type="GeneID" id="22572522"/>
    <dbReference type="KEGG" id="lpan:LPMP_080600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000016300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_080600"/>
    <dbReference type="eggNOG" id="ENOG502SP26">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266791at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001838999" description="Transmembrane protein" evidence="3">
        <location>
            <begin position="40"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN95869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="24618" checksum="8FA0B436E0ADA992" modified="2014-11-26" version="1">MMSFPLYHPKMSSATKPTLRSKLALWCALCWLGSSAARAAVPRSFTLSLSSSAHAEVWMAASVPTSGPDVEFPPNSVVYEREKYSLPPKSFFSRNWYVGILIIVLVVLAAYTLLAVWVCYRLEYAEQRKAKKVVEQAYATNGFFDLDRYIGRGATGIPAEQCNRSSNSSGTALRSTQLSRLLDEQEETYGSYSSSDSSPWSESDEDAVVHVNPLQPQAEVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLI4</accession>
    <name>A0A088RLI4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_150610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697436.1">
        <property type="nucleotide sequence ID" value="XM_010699134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLI4"/>
    <dbReference type="GeneID" id="22573481"/>
    <dbReference type="KEGG" id="lpan:LPMP_150610"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000042600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_150610"/>
    <dbReference type="eggNOG" id="ENOG502SIZ7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1434354at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF1">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="265"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="512" mass="58095" checksum="3BFE6B4E7A42E466" modified="2014-11-26" version="1">MSSLDACRELYETDLANQTHCCGLEQIKEEHKAANRHVFVQLLRYQEDINTKGSLPFKLDPTEEQRKSKGSSAAPVYPESLTIRDPRQLKQILPIPDIHKVSDCDLIYRFLIARRMDVSLATSDILHYIGFREKYNLDTILWDHEVVATFNGLDGEELVGQVMAEMKDTTSAAKVKITRPLLKAGWAACYCGVDKRGHVIFYQRPNPKELAMLERRWPYVEGHYDCRSPDFHSVTPPYSNLLPRLYLRELEKGRRISRLLNHNQQHIIREVLRVQAGETPTSTDTFRDNGGGATCLVDVGNVKVSHIASSKFKKVFKLFRLLSLMGQSFYPENMNRMIIINGGFVFNMLFKLVRPWLDPQTQKKIVLLSHTNKAALSDLSGDLNHASPSSATSKSDESEDDGAPVTGTESEKAKFALRDALSEYIHEDFIPSRYGGRLPVVDSPLFYGSCPPKRLAENPHYPAACEHVRARITPELLQDEFIFANAKEGKAATQEEWKAFCTMIEGILPRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMQ3</accession>
    <name>A0A088RMQ3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Katanin p60 ATPase-containing subunit A-like 2</fullName>
            <shortName evidence="8">Katanin p60 subunit A-like 2</shortName>
            <ecNumber evidence="8">5.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">p60 katanin-like 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">KATNAL2</name>
        <name evidence="11" type="ORF">LPMP_130850</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.</text>
            <dbReference type="EC" id="5.6.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
            <location evidence="1 8">Cytoskeleton</location>
            <location evidence="1 8">Spindle pole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
            <location evidence="8">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
            <location evidence="8">Cytoskeleton</location>
            <location evidence="8">Spindle</location>
        </subcellularLocation>
        <text evidence="8">Localizes within the cytoplasm, partially overlapping with microtubules in interphase and to the mitotic spindle and spindle poles during mitosis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 2 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.1" evidence="8"/>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697167.1">
        <property type="nucleotide sequence ID" value="XM_010698865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMQ3"/>
    <dbReference type="GeneID" id="22573195"/>
    <dbReference type="KEGG" id="lpan:LPMP_130850"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130012800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_130850"/>
    <dbReference type="eggNOG" id="KOG0738">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="191529at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008568">
        <property type="term" value="F:microtubule severing ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051013">
        <property type="term" value="P:microtubule severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000434">
        <property type="entry name" value="Katanin p60 ATPase-containing subunit A-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03025">
        <property type="entry name" value="Katanin_p60_AL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027497">
        <property type="entry name" value="Katanin_p60_AL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF78">
        <property type="entry name" value="KATANIN P60 ATPASE-CONTAINING SUBUNIT A-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="333"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="193"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="341"/>
            <end position="348"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN96514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="587" mass="63586" checksum="7A829B968AC5019A" modified="2014-11-26" version="1">MRHLQPLSNTAAPAPGSSLAHVKAQQLAREEEEKLRARRVKGVIVLIEQFLLEQGYSQTLQALQQESRISLTQFSAADNIDLLSVVQEYEEYYAFKCQRAPKLYRVRGGGSDAGGVGSVIPESGERVLSRKRRGAAASCPETPPSSAPATLPLLIGYGNVCGGATSSSSPPSLSSVGRPPSHLRPTNVMRALNHTKTNGDNGPANGDKRAAAPVSDTSEPGLSLQGESVTTHICGSEGEKGRREKGGNADSSNDAADDFFGPLANHRIRKPLPQFATSELNDLAATILREIIDVNPSVRWSDIADLEGAKHLLQEAVVMPVKYPELFQGILRPWKGILLFGPPGTGKTLLAKAVATECRTTFFNISASSVVSKWRGDSEKLVRMLFDLAVHYAPSTIFIDEIDSLMSARSSDGEHEGSRRMKTELLTQMDGLSKRRGGEVVFVLAASNVPWDLDTAMLRRLEKRILVALPTHDARILMFRRLLPKSFASDTDYEACAALTEGMSGADIDVVCREAMMRPVRKLIAQLEAAGNSCDAYAQLPHEPLKSPAPTLEDVQASVACTHSSVRLADLDKYDVWTREYGSGLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMV4</accession>
    <name>A0A088RMV4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dpy-30 motif family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_180520</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dpy-30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697886.1">
        <property type="nucleotide sequence ID" value="XM_010699584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMV4"/>
    <dbReference type="GeneID" id="22573942"/>
    <dbReference type="KEGG" id="lpan:LPMP_180520"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000045800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_180520"/>
    <dbReference type="OrthoDB" id="263203at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22965">
        <property type="entry name" value="DD_DPY30_SDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007858">
        <property type="entry name" value="Dpy-30_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049629">
        <property type="entry name" value="DPY30_SDC1_DD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05186">
        <property type="entry name" value="Dpy-30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="167"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN97233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="20142" checksum="4C7598A40D22D9AE" modified="2014-11-26" version="1">MLSSSVEAVDEETLHTLLMHLGDVPSGAIAAAVQAAPNAPAKLETTSSPAFLSGTFSGLANECGKGDANADDDIPEYALPDAQYIERTMLPLLLRGLEVVAQVRPPDPLAFLGAYMICNNPQKPPAENGSSASAKGLEKVIPTRGSAPVDDTAPPALEEVVTQAMSRFSTSKSNTSATPKPTVAVGRGASAVTKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMW8</accession>
    <name>A0A088RMW8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histone H3 variant, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_190600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698055.1">
        <property type="nucleotide sequence ID" value="XM_010699753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMW8"/>
    <dbReference type="GeneID" id="22574114"/>
    <dbReference type="KEGG" id="lpan:LPMP_190600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190014800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_190600"/>
    <dbReference type="eggNOG" id="KOG1745">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4025405at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000077">
        <property type="entry name" value="Histone H3 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45810:SF1">
        <property type="entry name" value="HISTONE H3-LIKE CENTROMERIC PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45810">
        <property type="entry name" value="HISTONE H3.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="3">
        <location>
            <begin position="53"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN97402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="145" mass="16419" checksum="AA6F5047C3422E08" modified="2014-11-26" version="1">MAGVTKSAVAAKRPSKSVASRKANRMSRKMAKRQVKEQHAGAAGTKRQHRWRPGTVALREVRKYQHSTEMLISRAPFRRLVKEVMSTIKDTMRMRSSALEAIQEATECYIVSLLGDANLCTIHAKRVTLYPRDLQLAMRLRGDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMX2</accession>
    <name>A0A088RMX2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleoside triphosphate hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_140060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697242.1">
        <property type="nucleotide sequence ID" value="XM_010698940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMX2"/>
    <dbReference type="GeneID" id="22573273"/>
    <dbReference type="KEGG" id="lpan:LPMP_140060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140005400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_140060"/>
    <dbReference type="eggNOG" id="ENOG502S3PC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="365445at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46688">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46688:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN96589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="191" mass="20282" checksum="677CB4D3B704A309" modified="2014-11-26" version="1">MLSSVTYVLGTESCGKTDLVRQLEYLSQGVVRTVPTSCTPTMGQEVTVLTIRSPAGEGKVTVEVRELGGSLANVWESFIESRKAKEIGGGATAFLLLYVVDGVAPHQLPLASTMFRYLTQGRHATCAGWSTLIAVQKCASVNAVTAEEVRGFFLDEVSTPSNVDVVEVDSWNGIGAGDVLRGIEAVFGAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RN17</accession>
    <name>A0A088RN17_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_180240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697858.1">
        <property type="nucleotide sequence ID" value="XM_010699556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RN17"/>
    <dbReference type="GeneID" id="22573914"/>
    <dbReference type="KEGG" id="lpan:LPMP_180240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180007400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_180240"/>
    <dbReference type="eggNOG" id="ENOG502S5D4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="251450at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="127" mass="14448" checksum="A62615CF9FDB5D04" modified="2014-11-26" version="1">MGGQDPEQLTRYQQGQLAERLGNYVSGLASDKLRCMHAEEQSTKRYTQDGTPTGENYWFEAGNTLSSPAVPEFIKDEILKDMQQERSVKSPAFVQPAEEEKLATEDDDYASHLRRQRHKLLRGSDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNA2</accession>
    <name>A0A088RNA2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Importin beta-1 subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_200500</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698249.1">
        <property type="nucleotide sequence ID" value="XM_010699947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNA2"/>
    <dbReference type="GeneID" id="22574257"/>
    <dbReference type="KEGG" id="lpan:LPMP_200500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200008800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_200500"/>
    <dbReference type="eggNOG" id="KOG1241">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10263328at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="22"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN97542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="870" mass="96115" checksum="DE3F12627AC66FE1" modified="2014-11-26" version="1">MANVTDLLMALGSPEPSIRVPAETAVNNAKETDLATFMTTMLQEFRDENKPTFARNMAGTLLKNAVAPSFREVAARHALEEQWRALPADVRLQIKNEVLSTLGSPNRDVRTVAANIIGSLARSELPSGEWPQLMGILIGAAKSASEQHQEAALTAIGYICEEGKDHEEVEEALKPSTTEVLSAIVQCMASANEDVKFSATNALCNAMEYIHDNMDVPEQRSYLVTALCEMANACATVRTRERAMESLAKVAELYYSTLPDYITRLHEITTNAIFHDEETVGLQAIQFWISICELERDMKEGGDMLSSLNYSTQGLTFLVDICTQLLIRQEEDQTEDDWNLSVAGSKLLQSLAEAVGIPIQRPVMDFVYANINSTEWRKREASVMAFGCIIGVQEPAAQEAIQDTVAQAVPGLMEYLRDSKEMVADTSAWVLALVCEGFVDIFLQTPDLLQRLMNDVGPMIGGDNARMGIRACHIIYNIALAYADEEDQQTNEISRYYSDLVGVLLHAIDHGATNDFKSTAQETLNALVDAAANDCSSAYLMQLPQELLARMGPQLSLLQQSSGDNRESETMMGLLCGALAALARKLKEDFMPFLDASMQIVMQIVELSADYVQQEAMTAIGSIAHAVKEQLAPYLAKVIPHVLKYLKAFDEPEGIYAVVATMGDLSLSCRVMLQPFESDIMNTLYVNLTNTEVDRELKCSFLSCFSDFILNVLGSERFKPYMPALLPLVDQLFRASCEIDIRGDPESEAYVMNLWETTASFYSTITQCFKNTDIDALAPYMANILSFALHAAANTSEFEETQMAALMVIGDTASALCNVSDPQVRAEAKQALLTDAMNGILNQVLRSSTSEDTKKHMKWIRNQLTHLQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNA4</accession>
    <name>A0A088RNA4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_190800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698076.1">
        <property type="nucleotide sequence ID" value="XM_010699774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNA4"/>
    <dbReference type="GeneID" id="22574134"/>
    <dbReference type="KEGG" id="lpan:LPMP_190800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190015900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_190800"/>
    <dbReference type="eggNOG" id="ENOG502SHKF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273774at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="714"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="871"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="581"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="649"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="885"/>
            <end position="895"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="895" mass="96991" checksum="0575DEB06F6FCB47" modified="2014-11-26" version="1">MDVLLHVVQTTSASPPSAPSLCDDRSQHTNLDAPVVLSANGSHTSFTVESLRLSRTEARLGSSVSAQWHVALCSPAEDESIHGCDGDPHAFFSAALSRCPPAAPLSPVPSSTVHISAVSVDITDLRGRRSPGGHATTATVDVLREKLHYLCAAFVRAGVGGADAPPVAYAETAFFFGSRLGTRKDALYLTALHRLLVEALLIVKDRALLPPSLPPLDVDVSLVDYDEVWGAGDVLAAEVAQPSAHGTHVQRSRVTWMPLAKLLEYVPRPQNAMTGTSTTLPWTTSLTETNSKSQTSATQLAQLVRQRLQGWFDRIDSATSEFPSAPVSPSPPAAADRLRHLERNTLLFTLRLRRCTSSSTPALQARVSAAYFTLVLLPECGATLLHGEAGAAVAAMCMSSRRAGAALWREFEALSAFMRSLPQSSHCRSDDKQKRSSYKKHDRTTAATVQAQMHAAALRRSRWLTTIARIHDPLTLLTRAPVTATGEHSSDDLVDCFLNSSTVRSFSWIGCIAAAASHQRATRSTLAFLSRLQPPQRARRDCPASVMERSPEKATGAPLARHLHTHHKNAADDTNERDAPRAQAASSSSATSTPPLPSPRPSANAPRPYFSPRPHGGSATSINSSKKARTAAASYLPLSDEPNTTVDPVAASSRVSHASRGSDNNDVSSEDACQERAPPPAQVEALVASLRVYASVLEEEVRRLRRRLQRYEAAPYDSRGSTGDPPVRSPLQETQGYDSSNISVGFSALHATSPGVCDSLPHLVQVAVDDLRTDARFPLALHVKLNALIQRLSNSYTAAVQVRRNDAADSPAVMQQRNEKREVRDAYVAQLEATVALYEQKLALMDYYVAPTLMQCVDELDQWQQQQQHHRQRMHTALTEVSLGPPHPYPTLLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNK3</accession>
    <name>A0A088RNK3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_190820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698078.1">
        <property type="nucleotide sequence ID" value="XM_010699776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNK3"/>
    <dbReference type="GeneID" id="22574136"/>
    <dbReference type="KEGG" id="lpan:LPMP_190820"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190016100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_190820"/>
    <dbReference type="eggNOG" id="ENOG502SMHQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265294at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="562"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="513"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="591"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="607"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="810" mass="87024" checksum="7A17494353BC5AA5" modified="2014-11-26" version="1">MSSSSSAPQREQLQQQVPWTFSAYHTVVLTEFVSALQAEVRRQQDAYDHAVEMLNASVDTGPTSDMLELGIPLHATHEEQVQVLQDMYALATLDTRALVALGPYRLLYTLKANMTRIEDERRAGAVAAGNGTGGRKMRLDRPPFVLKSETSIGTTALECNEDSPTPKHHVVPPLSVRIKAERIDNDMYEGVAQQQQFLSEHSPLASLSLSLTTATPALMPAKEERHSTKGATVSSVGGAGAGGLGGGCPPSWVTLKKEAAQPPPSNDTYNGAYFVPCPTPTGAPLARYVSLSARSLSTNNSTQSPSAPLPTLVAPVSSWSKVMSSTNGKKRPAALSSQVPKRCRSVTTSQANAVAADKELFLSQAQRPKVACMQNRVRLLHRPHSPSSPSKETREGDRAVQLWWRVWPNFAPMWLPDVRKSEQQQRTTTAPPSIPHECVRPTPAMVAALIRVAEQNYERDCERCAAKQAYLTTMLDTPESLRVSGVALGTADAKNAGQATLETSLVLPDPQALRQLQDELASAQAKLNSAYAERLALLRELKAALQDESVVCVDGATVSEAGETKHAAPSPVSRAQHRAASPSGGLKRSQRSSSTHYATRASTAIDVEARNADRRGEGEAVSDISTKSAAAGVAALELLHSALADPTSLLQKAYKARDSLAFCSSEVASSARTRGPRSQAASEETWDLPNGIIGINLPSLEHDRNAPDLMEYLWPEDLDALIRHELRGVVSAKSHNPEARSVHVVLSAVQVRQLEEAACAVSTGDSASQLQVVVLPMVAGSLMAHPKFVESGWLYVHGRGETIGAEVELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNQ2</accession>
    <name>A0A088RNQ2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_201930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698394.1">
        <property type="nucleotide sequence ID" value="XM_010700092.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22574402"/>
    <dbReference type="KEGG" id="lpan:LPMP_201930"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200024700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201930"/>
    <dbReference type="eggNOG" id="KOG0379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250130at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000211">
        <property type="entry name" value="attractin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23244:SF498">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23244">
        <property type="entry name" value="KELCH REPEAT DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="980"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1245"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1339"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1446"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1511"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1717"/>
            <end position="1744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="982"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1245"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1474"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1487"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1717"/>
            <end position="1731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1931" mass="206995" checksum="AE14539651C3C2FD" modified="2014-11-26" version="1">MSSTSLLPPQRGDAVQVQFVNTDGSTIAQRPIPIEELLQQQDHTMDISDGIALRLEALNAEQDYSDDDSSMSDGTADDKEGTEGAVARGHAVAAATPPPGTRVTRDWYEVLDALRREQLDVRRAMTGVEEAMRKPSEGEGRLVTRHSKKLRCVATPLKRFSIAPSTEGKSIAADAAPRSVPPPGASRREVWASLAPAKDVYPHNYKVLRYVSYMPALDCRRFRPTALAFHAAASYLNRKDSGQRLLVYGGVSFGTRSVEQELYEFSVLTGNWCRIEGRQLVPAGHYGHTMTVVECFDRLVVVGGIGPGGATVSPKTRQAWSTDPLRAPRYRYLCPLLHRPAGKVANMLARAGGTAAPLPPTPSPPSIGFVSLLFDMNLSDQSWRAIQPPTPFPLVFHTSVYFGTELFIFGGLTADLHVSWQLLAINPGTYAVRRIQTSASPPRRGRRGMAPGDEGVEQEGSGSDVDVDETDGPGPRFLHTAVRYGQYMIVYGGYGTQNEVLDDCWAFDMANERWEQLRCRGGAAGRAGHACCVVGCRMLVTGGFESSLDEIGTSTSPVTTVMELNLVPTVQGEHMWRAEVRVQPPLPPLAFTQCAPCGDGHSFLLFGGLTKPARHPTRSLSVGKRSASTKRRAAAFSEDESDAEDVAESVVEADHRSASRKVSERGASVAARDGLWRRFAPFDDGLVLTFPEKRRHSVGAKNGPVVNALGVEVDPEELPQHFKAFVRRQEDFLKKKDATTVETMRKTTLEELEEMEPALYLTDAEIELLMHRSEECCIAFSERYKMNMLPSNVPDREERVHLIEECISESRQVRDVMRSMKGSTPGVTAVKSKTHRKRTGQKFEDYSAAKPFRRVVVMQLITSINNHLSRMHRLNKTLRTVDWPEKKGFLEAIDDMQNSVHAVSRAINGVLNKYIQHRVESLMKGVEKHKEVMRMLTEVVEKNRHDKIWGIEEARNEKRKEQQRARAAVVPLGHPVLTVKQAPSQRRMPSSAARSRSSSPAAIRNRSTPNCSLGVGYHADESKAVAYVMDREWHDLLRRTSMVEKCAGRLRRYCEEGAATSGTALPPSPPSVKDPLLTHLASPQAPSVMTQVPPPLQVPPLGSFDPIAPPVLLPTGVPLAGLVTSEAPGAPLALASASTMGEADAARPREITIQRSNELRVTAAGVAEEVRKAAVSLRTALTQVAAETPLARSAAVSLSSKISHLTAAPSQTTVGTDAVTHTIPVPQLSVPTVVSSHTAAAPTASGTALAARSAPSDTSSSSSLGSSRSPSSSGSSAPAAPAATHGPSPQLLSGGSLPSATTTQPTSPGYVPPPVTVPVMPNAEAASAKVQQPDLPLAAQSSHNAAADSSHPSHNAKDTAGSPAQASTAQRHAVHLNTLRPLLAARESLLQFQDKVILIRLNKWDTSDLAGPPQDMKVEELYKRLSKLLTGVTQCITASFLTKAGARPPRLRPAPLSVGPPPPPSRSKKAATERGTSGVITKRSSQSKSLTSTAAARASSTPAVFSEMSFSAAGDNEGGSRKDHCPAEGALHGTAEGSVRDTLRLKPLPLPSYDQDASAGDEWLTRLSRPTDNGAAGVPLVSNEALLRNVRSEVAPAALSSTDTAALAAMQVHAVYPGARTIPNTNAASVVCGNIAAPMITGPWAPTVPSMQTGGSAFVGAAAPAVSLSVVPKVVLPAGANGVCTDKAGAAFMTQSSLQRRRSTIADLMQLRHPFQNRLSSGNLGDGTTNIGDGKEPVTREPATSVTRGNFVVNAEYLSRAAPHALLAAPTAEDQLQESASGVQLAWADVDEDYFYFGRAVEKRTTPAAAVVSGPPYLFTRPSVGVGVSPPVGSVVGSPRANAEWVVPPTRDITGVTSVSAAPRTRSSTARRSISSRRVSDHYLLSTASQSLKSHTARPVVRKEGAKHNFYTPGELQLMHARERLRSKPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RP89</accession>
    <name>A0A088RP89_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Small nuclear ribonucleoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_170260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697717.1">
        <property type="nucleotide sequence ID" value="XM_010699415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RP89"/>
    <dbReference type="GeneID" id="22573769"/>
    <dbReference type="KEGG" id="lpan:LPMP_170260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170007900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_170260"/>
    <dbReference type="eggNOG" id="ENOG502S9ND">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266723at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="195" mass="21560" checksum="D0124A35ED5B0803" modified="2014-11-26" version="1">MRALGLVVKASDDTDDKGENSSALLTSSIEVEVETNQGYVYTGKLVHIDARYNVILHEALVRRARSFDVERAILREKSQREAQLIASSLQGVVAEEAEVVRSTNEFMPRPRYIGVTYIRSNNIFFMRFIDGAARTGTSAASAVSTHSALGRLRSEFVAMAAAIKAHLQREKMRNRAARRKRLEAKNMTGGSGGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPC4</accession>
    <name>A0A088RPC4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATPase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_203070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698510.1">
        <property type="nucleotide sequence ID" value="XM_010700208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPC4"/>
    <dbReference type="GeneID" id="22574518"/>
    <dbReference type="KEGG" id="lpan:LPMP_203070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200036600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_203070"/>
    <dbReference type="eggNOG" id="KOG0739">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="263010at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001003">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF163">
        <property type="entry name" value="TRANSPORT PROTEIN 4A, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="213"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="470"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="474"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN97803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="563" mass="61544" checksum="443B85DF8621513A" modified="2014-11-26" version="1">MFDAHCTPVPAVVPTCSLCFVCSYALLTQGVMEAKKVEETRVLVTHARDLLRHHLAAAPHRSLCINKRRELRTTLQQLLPCLSIVQSYEQQHTYLSTYELTIGAVRQVLVSLEVADAAVDAKDRQLVNAQYKVEYHGREDNVEGCAALPKPTAPLRTAAEAPVLASCANRAPATAPSVTWRNTYGCEDAILALRQATTLPLQHPFLFTGPRQPWRRLLLYGPPGTGKTRLAAATATEYGAVFLSVSAADLLSKWVGESEKQVRQAFAQAAASVPRCVLFFDEVDALCSARGGHGESELARRLKTELLLHLQADLPTVTVLAATNLPWELDAAFLRRFDRFIHVGLPSNAVKRRLLAKELRGVTNTITGDALDRIVAQTERFSVVDVRRLLSYAVMAPVTEWLLQTQATVDDRSSDSGESTKEGSDGIDVVCAGAATAPAPLLYPSSPSRMHIEPKYRSVPCLQDTEVLGDGVRSGSSGTESTLSPCNSPLPSSRFGPEHRLSTHSSSPLHCEHSHRGRLISRTNDVPHVECHHFEDALQAITATTSADEIARYTTWHSRSICV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPU9</accession>
    <name>A0A088RPU9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dynein-light chain-protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_180730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697907.1">
        <property type="nucleotide sequence ID" value="XM_010699605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPU9"/>
    <dbReference type="GeneID" id="22573963"/>
    <dbReference type="KEGG" id="lpan:LPMP_180730"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180010200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_180730"/>
    <dbReference type="eggNOG" id="KOG4081">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10059120at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21455">
        <property type="entry name" value="DLC-like_DYNLT1_DYNLT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255:SF17">
        <property type="entry name" value="LIGHT CHAIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255">
        <property type="entry name" value="T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="255" mass="27053" checksum="7E632AE3951E7BEE" modified="2014-11-26" version="1">MADNSSTNSTAAGTVNSDLNLTRIGAETATLRGSFSAGEVSKRATISEQDALDHHQGSTAAGMANDEEGEAATSPPKVRVAHNSDGSVNRDEEGEAEEDEEDAEHLERVAASDVKNIILQALSPYFDDDAGGSAAVAPGVDLAPPPSVSGPSAVNPRATTPAIEDDHDEEDTAQRYDHFKAEEWIALVCDNIMERLVALGKPFKFVVHAMVTRKCGAGVHVCSSCYYAPMDGWLSHAHDLSAHLYAVVTVYWCAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPY6</accession>
    <name>A0A088RPY6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1935 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_205420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN98033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698740.1">
        <property type="nucleotide sequence ID" value="XM_010700438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPY6"/>
    <dbReference type="GeneID" id="22574754"/>
    <dbReference type="KEGG" id="lpan:LPMP_205420"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200061100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_205420"/>
    <dbReference type="eggNOG" id="ENOG502S33Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269245at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015232">
        <property type="entry name" value="DUF1935"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036310">
        <property type="entry name" value="Smp-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47047:SF7">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47047">
        <property type="entry name" value="PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09149">
        <property type="entry name" value="DUF1935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101601">
        <property type="entry name" value="Smp-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1935" evidence="1">
        <location>
            <begin position="14"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="133" mass="15223" checksum="196383541725F164" modified="2014-11-26" version="1">MGSGKSKEAALVTYKNGRPTVKGTRTYSMFSNILYRIADTDANRWAFYNDSKDYIIHVAILFDYDSQIVPLGDTTAFRIDDPDEGNEDDFGKYLCEVDVRPLETQLFVEGSVTGWRVDTLEARTAEDEREYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQ96</accession>
    <name>A0A088RQ96_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_211840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698969.1">
        <property type="nucleotide sequence ID" value="XM_010700667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQ96"/>
    <dbReference type="GeneID" id="22575006"/>
    <dbReference type="KEGG" id="lpan:LPMP_211840"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210022400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_211840"/>
    <dbReference type="eggNOG" id="ENOG502SFNI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266937at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="144" mass="15304" checksum="BEDFA2B0C6C6CFA2" modified="2014-11-26" version="1">MPGREPPAHRGAQTSVSARRVAAPYASRRPPDSHAARPGLAGVQCSGAAPLTAVATASRSDQRSPIPAEGAPACPSCAARLKASQEVLRAYNALLLNSKQLFIDDALHHYSGDEAWIRVLRSLGWFNEGTPVNGAGRRRDVDQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQ98</accession>
    <name>A0A088RQ98_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_211900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698974.1">
        <property type="nucleotide sequence ID" value="XM_010700672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQ98"/>
    <dbReference type="GeneID" id="22575012"/>
    <dbReference type="KEGG" id="lpan:LPMP_211900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210023000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_211900"/>
    <dbReference type="eggNOG" id="ENOG502SHM8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="261305at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="26834" checksum="C4DFDF7EABBB7804" modified="2014-11-26" version="1">MKGFSTTGKFSTLAATKPKKGEVVSTSPEATVKKYKEAMKQHKKALKELHMCTESFTRALTAVATSFQFLASDTCIPVIIQSSGALACGIEEVQDGVALQALMEAIDYSLSARFEKIADHQRELKESCKRKSKAEQTLALLCTQCDKLKPTKDADPKAQAFYLAETQKRVEHELECTRLRAEFEDAFHDFETRFGILVYEDMKELMEQLHRVLSALSYQLRKCKGSLLAGPAIPQSLAVMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQG9</accession>
    <name>A0A088RQG9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_211140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698900.1">
        <property type="nucleotide sequence ID" value="XM_010700598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQG9"/>
    <dbReference type="GeneID" id="22574936"/>
    <dbReference type="KEGG" id="lpan:LPMP_211140"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210015600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_211140"/>
    <dbReference type="eggNOG" id="ENOG502S2PZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="427138at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="334" mass="36490" checksum="D45FE1AFA24D161B" modified="2014-11-26" version="1">MPSSPESPLRALFKALEKKCPKYHQEFEQVCKVVGQTAVALDRASPYFAKAADYASVVKEQTTRFKLEEFGPMLLGLALCFFGGAYTMLIAVVETVHLLCWEDLKHSFEVLYHNYELAAEQNRKDNCVDVEGNGVEDVLEMCHTELLSCKAVLFLKSVDVEAAQMAGRTFGAAAMAVIAALRVKFARSLALGGSLANMAMDYIPLEEALRDALPAEHKKWAGVIAKVVINAIAMMLASLVSGAIGMLHSCIRGAHMFVQHTVHLAKDHGLLEDDMTLDNPKAKALVAVVASIGLLWQATHTEANPFPINVFLLPFTVAEYALFFLVNGFLFAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQK0</accession>
    <name>A0A088RQK0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-nitropropane dioxygenase, putative</fullName>
            <ecNumber evidence="4">1.13.12.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_211500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.13.12.16" evidence="4"/>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698935.1">
        <property type="nucleotide sequence ID" value="XM_010700633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQK0"/>
    <dbReference type="GeneID" id="22574972"/>
    <dbReference type="KEGG" id="lpan:LPMP_211500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210019500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_211500"/>
    <dbReference type="eggNOG" id="ENOG502QQW7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10265891at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF20">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN98228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="317" mass="34241" checksum="23668B471BE90CBA" modified="2014-11-26" version="1">MQASRVISLFGVQYPIVQGGMVWCSGWRLASAVSNAGGLGLLGAGSMMFDVFQHHVRRCKKATKKPFGVNLSLTHDMSRHIEFLIEEKVPIVFTSAGSPKLWTQKLQSHGIKVAHVVPNCKLALKCEAAGVDAVVAEGFEAGGHNGREEITTMTLIPQVRKVLAPEIPLIAAGGIASGEAMLAAMALGAEGVQVGTRFAVTQESSAAEEFKKRCTAAGEAETWLTLKQYRPTRLLLNDYGKEARRLSESGATKEQLKAFCGEGRTKRGIFDGDLANGELEIGQIVSTCKDIPTAAEVVERMVKEFRARNEQLAKMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQM2</accession>
    <name>A0A088RQM2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_211800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698965.1">
        <property type="nucleotide sequence ID" value="XM_010700663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQM2"/>
    <dbReference type="GeneID" id="22575002"/>
    <dbReference type="KEGG" id="lpan:LPMP_211800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210022000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_211800"/>
    <dbReference type="eggNOG" id="ENOG502S6UR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273161at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="269"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="338" mass="36337" checksum="8D563AE2080771B5" modified="2014-11-26" version="1">MESNHIYTMLQQQQAVAVAAAQLEQAYNQTCYMLQQCSHNALLTVLMSLLTDYPTTLVQPIRMRVEQVLAHQMSPAAPGRVMVSGRRVSDFVPNSSAAPWTPSSMRGSAAPTPTANSTTPSHRRGRGHKGKEEEQEMCSIHNNLRAIKHLQLNVSTGLYECIHGFHCLVDGPAGASPKRATTTLAVSPSVPISRTNDPASPVESQPFVSPPTVVAPASAESRFSVSEVEALRMLGYSLPNTSPDQPQPHLAYDSSRPQSTLQQSHQPFSHTSLHSSGLGLSGPSPHDPESAQLGNGGGFTVISGDRSSTGTSPLDPRLNMDIPSLEYLLQSVRDIDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQP3</accession>
    <name>A0A088RQP3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_212110</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Vacuole membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698995.1">
        <property type="nucleotide sequence ID" value="XM_010700693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQP3"/>
    <dbReference type="GeneID" id="22575033"/>
    <dbReference type="KEGG" id="lpan:LPMP_212110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000022600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_212110"/>
    <dbReference type="eggNOG" id="KOG0232">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1744869at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000001">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0926">Vacuole</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839037" description="V-type proton ATPase proteolipid subunit" evidence="10">
        <location>
            <begin position="21"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="11">
        <location>
            <begin position="37"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="11">
        <location>
            <begin position="116"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN98288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="187" mass="18872" checksum="E6C9C2F9A6A2B450" modified="2014-11-26" version="1">MKCQIASVVAAVALFGSAAAVSCSDKYPQSSAFFGSMGCASALIFANLGSAYGTAKSGVGVAHLGILHADRIMRGIVPVVMAGILGIYGLIVAVIINNNIKVEDNSYSSFAGYLHFGAGLAAGLSSLAAGLSIGIAGDASARAYGKQEKIFVAMILMLIFAEALGLYGLIIALLMNNTAGKVTAGCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQS3</accession>
    <name>A0A088RQS3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_220230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699025.1">
        <property type="nucleotide sequence ID" value="XM_010700723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQS3"/>
    <dbReference type="GeneID" id="22575069"/>
    <dbReference type="KEGG" id="lpan:LPMP_220230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220007500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_220230"/>
    <dbReference type="eggNOG" id="ENOG502SJ9W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265402at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="328" mass="34657" checksum="7D4786FBFBA7C2CA" modified="2014-11-26" version="1">MSVHAVEESDVGLPNMQLEHHEQAAQQKPRPEPSNAPTQVCIDKTVSRSPSAKRYRFEEQEPKDISADAVHVIDLKEDAHLEHAGRASATVALQDDHTDFADAPVGDAAAVVDVSCSTLCAEADVTGVSDETLAEPDLATGPACVEEKCALTLSVCELETSSHAQLSQVMPHAVRKDIPVQPLLLEDGNAVLPPLHQCTDEEEAVVSPLLVLTEALTHLSQAEGTTESGAIAHDSVTIGTEDASRCEAEESLCRDTEAGPVTNTANATEVASRIPVEGEKDSLRSARSSEAATPPPSLAAVDEYPKEASKHLTFASDALPQSLSQRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRN6</accession>
    <name>A0A088RRN6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_231100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699267.1">
        <property type="nucleotide sequence ID" value="XM_010700965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRN6"/>
    <dbReference type="GeneID" id="22575315"/>
    <dbReference type="KEGG" id="lpan:LPMP_231100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230017800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_231100"/>
    <dbReference type="eggNOG" id="ENOG502S2NE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266799at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3680.10">
        <property type="entry name" value="TerB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029024">
        <property type="entry name" value="TerB-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158682">
        <property type="entry name" value="TerB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="385" mass="42240" checksum="A4A4800A546D7449" modified="2014-11-26" version="1">MLKLSRMARSSRYTPVVGCAFLVEMLYGSKYSANLGLYNMPYVYVKTILLCATGHSLMLSKGRYIRGLVELLLPSKVSQDNLTKLELLQFVDAIPVGRYGSGNTDSATMDEDEAEKQAMLALMMHSNIDASSADTTAATIHADYCTSSLPPLHDEHSEVRHAREDRWDWRCSRLMRAAANDRKGDGVLARLGSDAAAEAVRSRSDELEEDAVAMESIMSFVSATMFPSSIARVLIYDAVCTCMADGLYRSKEKERVTLVSSHIGLSSAVRGQIEKLALQEKVISIRKRRLLLLHPFHSNTTPMGEERRWQAFSTLGSAAKNSTSHERGEGGAGAAGRSDVGDRCDQEAEVEASTFAAEEAMRVAAAKALLRRARARRSTKRYAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRS4</accession>
    <name>A0A088RRS4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_240030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699345.1">
        <property type="nucleotide sequence ID" value="XM_010701043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRS4"/>
    <dbReference type="GeneID" id="22575412"/>
    <dbReference type="KEGG" id="lpan:LPMP_240030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_240030"/>
    <dbReference type="eggNOG" id="ENOG502SA7P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="263864at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="166" mass="18418" checksum="1D139049224FA9D2" modified="2014-11-26" version="1">MRALSFRSLAAVPAGLATRCYGGQCGARPPAGGRYSRGGSLPYPDRRNVPTEPQIVARLITFFPPNKAFVPISRWAAALPDDLRETLVPYGGLSAFVSAQSNFFMIRKENGMTVASLSAMGTELAREHERKEKQERKRAEKFNQRRGNFAPRGRSFSPFRGDPSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSC2</accession>
    <name>A0A088RSC2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Calcium uniporter protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LPMP_210380</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCU (TC 1.A.77) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698826.1">
        <property type="nucleotide sequence ID" value="XM_010700524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSC2"/>
    <dbReference type="GeneID" id="22574860"/>
    <dbReference type="KEGG" id="lpan:LPMP_210380"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210008400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_210380"/>
    <dbReference type="eggNOG" id="ENOG502SAA8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="278338at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990246">
        <property type="term" value="C:uniplex complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015292">
        <property type="term" value="F:uniporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036444">
        <property type="term" value="P:calcium import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006769">
        <property type="entry name" value="MCU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039055">
        <property type="entry name" value="MCU_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462:SF10">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04678">
        <property type="entry name" value="MCU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium uniporter protein C-terminal" evidence="16">
        <location>
            <begin position="84"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AIN98119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="222" mass="25293" checksum="92344D36304D7D04" modified="2014-11-26" version="1">MLPLELLRYRNSLLLSAAAAPLSRRCIHSSALAKETASTRATTLPTTFIMSCRFLMTAAAANDSSSAHSSPRNASIDVSQLRGVRETLKKTLAAKRQQLDAMEHIKVECAKIAYHYPDVFMKQLFAFLVLQAVVLFDWTYVHFGWNFVEPITYLLGYSATWIAIAWYGAMQHEFGYEALRRALHDAKWDRLCKARQFDQKAYEALRAEVKKLDKVVRSLEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSG4</accession>
    <name>A0A088RSG4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_250530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699625.1">
        <property type="nucleotide sequence ID" value="XM_010701323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSG4"/>
    <dbReference type="GeneID" id="22575701"/>
    <dbReference type="KEGG" id="lpan:LPMP_250530"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250010100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_250530"/>
    <dbReference type="eggNOG" id="KOG0145">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="44"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN98918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="239" mass="26115" checksum="B7863BFB1A0A3859" modified="2014-11-26" version="1">MSLTQSRSPSSSPAQRSNPESVVAAVAGDHSTFGGCAFDPDALRNLIVNYLPPLMNEEQVCELFGQFGRIESVKIIYDKITGESRGYGFVKYRFYFSATYAVFCLNRFEIGGKKLKVAYANVQAAKEAYDLLRRSTMELSVQQQQAMLSMYYNQMMLTQEQAASAAAAMTSSGPMGGGADYDPYMNMMDSNYAMRQRGGTAYYGQGMYPGMAPGRGVYPAGTSTSVRQSVTPSMVPLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSR2</accession>
    <name>A0A088RSR2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab3 GTPase-activating protein catalytic subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_251550</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rab3-GAP catalytic subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699725.1">
        <property type="nucleotide sequence ID" value="XM_010701423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSR2"/>
    <dbReference type="GeneID" id="22575803"/>
    <dbReference type="KEGG" id="lpan:LPMP_251550"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250011900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_251550"/>
    <dbReference type="eggNOG" id="KOG2390">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="17346at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045700">
        <property type="entry name" value="Rab3GAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026147">
        <property type="entry name" value="Rab3GAP1_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21422">
        <property type="entry name" value="RAB3 GTPASE-ACTIVATING PROTEIN CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21422:SF9">
        <property type="entry name" value="RAB3 GTPASE-ACTIVATING PROTEIN CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13890">
        <property type="entry name" value="Rab3-GTPase_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab3GAP catalytic subunit conserved" evidence="7">
        <location>
            <begin position="784"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="67"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="508"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="595"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="761"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="997"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="534"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="549"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="600"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="765"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN99018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1220" mass="133453" checksum="EA3CFB120D4E954F" modified="2014-11-26" version="1">MEMMHVRSESPCEAPQEEIPLLIEDFSCANSFEEHVKAIEQYLADLLDREPLLQSFLVTPALAATGGDVPADEKNEADIESGAAASASSSPAPLLMDNDAASPPTASKVFGRTIPLYVTAPLSLDGDSSIVVEVHVRDADHPITQQYCTPLFFLIRKVMVSASYRESETSYLLSLLSTGVRQALLQQKNRVNGGVLRLCPEPSRAAAPGCAPPSHRQPAATASLLPSPFFYPDGCAPCFAPAGDSYKQTFVGFAPPLPACAALPPMPASSPAISAAEWTLLHQRSFTTRFLADAFGRIPVHCQSLSDYIDLFQLHVGQHSRIRSDDFDGICVSLWKKYVLPVPWKFHPYGLSLDDSQATDSEGAPLSATSFSLTWENVLRRENEYARLLCGGFTHDFGTPVPPLKHVQFHFQWNQLHDIETHEAAGRPSHLDPFQYALARATPGTPSPTALFFSSVTAAQAAQRKCSITVQAVVRDDKDIQHGVSGHLAEVLAKGYLESLTSATAVRRTSAHDANNGRGGRGAVTHEAQQSEDGANDSDGTAEESERDTDERRGGRCSEAELRDMAARILEWPGATVTLQESLIQLFAAPLASEDDDDASAYGDSDPGARQPAEATLEALSSKRGEAVVARHLRSLWGEWEAHQQSCSSEASALHRQRREGGAEHQTDLRRSYFPDSFFARFAFVCVTQALPPTDVRTLWRRCLDALHRLLSDAPHGQEEKSWQRLLNCLAMPPEDPPVDLRRPLLMQKLQLLRYAQEALLRPSGDNSSPTAPTMNTKVEEDRPDTSLATRPARHLITNGEVLCVPPPLPQPPTTTDEVMQRAIELNSLDAAAVESASIEWLQTDALYNDMCLFLHVNKAHEGRIVRFPDFVQWHSPRDFVASAGAESTTSPSLESSSPSLSDNYYLSERMQHQQGEGEISDGKGSAHVWWSLWRRAVPRSRDDIIQGLFQPLEQATKVLTWLAAIPTVELLLEVSNASIANALHRMLCHRCVLGDDGAHRPNGRGRPRDKAEWSSPKSSSTPEAPNRAIPATPRIRALHRYVRDKCTALTKDVEAASALFLSSRGAFGEGAAAQQSTAGSEAMITEVLRGLFANALHHLGEIEVSVCTAVGLQYLLGFSTDPEVTSTVHALSSPAAESQQHQATSLQMRAVTVSMATWSTAFAKQFVRAETREVQESMVRLTCMAERPLDTCACFQQLVVHQDTSRSLRLALALTEEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSR3</accession>
    <name>A0A088RSR3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_211920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698976.1">
        <property type="nucleotide sequence ID" value="XM_010700674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSR3"/>
    <dbReference type="GeneID" id="22575014"/>
    <dbReference type="KEGG" id="lpan:LPMP_211920"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210023200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_211920"/>
    <dbReference type="eggNOG" id="ENOG502SBGE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270966at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="161" mass="17322" checksum="EF93FEA595CDB0DC" modified="2014-11-26" version="1">MERARVRYVLTGACPPAYSGRVLHTYVQLRQPDGSATRIDTLKMNFCTNLAADMKDLAESIPAVRIRVLKAGRVLSDSDSLLQHLTPAEMETCLASADETAGDANGMLQKPSVLVHIVFQKQPPPPVANPNKEKNKGSNTAEGGNSGEGHEAKKDSCCCVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RT32</accession>
    <name>A0A088RT32_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Histone acetyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_261750</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699994.1">
        <property type="nucleotide sequence ID" value="XM_010701692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RT32"/>
    <dbReference type="GeneID" id="22576078"/>
    <dbReference type="KEGG" id="lpan:LPMP_261750"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260022000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_261750"/>
    <dbReference type="eggNOG" id="ENOG502SEE1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="440324at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015418">
        <property type="entry name" value="Eaf6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13476">
        <property type="entry name" value="CHROMATIN MODIFICATION-RELATED PROTEIN MEAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09340">
        <property type="entry name" value="NuA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="256"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="256"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN99287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="327" mass="34388" checksum="A23C237EBF416ED1" modified="2014-11-26" version="1">MSRRQHGGPKSANPEQQLRQEATVFLSPDVEKELAQILQRRDSVEKALQRMDVEVYDLETAFLKHCVSHGGSLFDGFGLERRENAHRNPVAVLTPLATSSSSIGRGGGVISLPRFDAISTSAPGSPLLSTIANGEHARKYRVLSSCFGVGGIGGESNGSAAPGLAVTSHSPTSLKTLASVAPPTASAAVFQIGSKGSSAPAFHYRIHFFSPSERVFSACSVGALSRVEIAKSTLAGSRGVSTSTWSTTVAAERRGGGLGKCDRGGSADRLRGGRGGGTSLSRAFGKQPNAAPLRRHQRDANDEVDDVDDSVAGSGSGDRRRRRRHTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RT39</accession>
    <name>A0A088RT39_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4460 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_261850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700004.1">
        <property type="nucleotide sequence ID" value="XM_010701702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RT39"/>
    <dbReference type="GeneID" id="22576088"/>
    <dbReference type="KEGG" id="lpan:LPMP_261850"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260023100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_261850"/>
    <dbReference type="eggNOG" id="ENOG502QR3A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275980at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028031">
        <property type="entry name" value="DUF4460"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027986">
        <property type="entry name" value="TCAIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31596">
        <property type="entry name" value="T-CELL ACTIVATION INHIBITOR, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31596:SF1">
        <property type="entry name" value="T-CELL ACTIVATION INHIBITOR, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14687">
        <property type="entry name" value="DUF4460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4460" evidence="2">
        <location>
            <begin position="3"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="729" mass="82011" checksum="82DF5311D939E618" modified="2014-11-26" version="1">MYKKALNAFFLKVHPDFFHHNVQQQTVNQNSVAQLNELLAWAREFKQGTLRSPPATSISFSFYRRIDDKEDGSANAATMQRSACASGARSSGGDQSMGSLFTKQAGQPADWPSDGSGFDDSGAGGSASSRHDSQTALIHSTFELPQGFVASESNRGLVERAVNKFLRDLLRRAECIDSVTASMSVAEDAAAARREAKPLRRRHQTDPRVKRKSGGKTLLDEASEAMTMQWTLTSVPTLEELMDADQVLFAKTLSPLQCSAALHTIRVSLGELHYDQWSSMPLIIDDHFAIGAGITGGLTIPWDFTAMQFISFLQQNAASIAQCRALVTTLATEVEQLIAELCRALELDDVLISCSHKEAMDVLRLLHRNKELLHGYGLTNLTIELGMHHATRANGVVIVDVSMKTSEQLRKWLQALHGKLDLQRKLYRVSKQMLETTMWHLKEFRDMVEPGGVDAFVNNDCTYAQRLGWAKELFRIGPALAHWDWKEFTFLLSPELDVDWSRRQLQLPHNFDGDAFVRYIEDVQQSAKEKDKEALLRASAMRRLSDEELRAQAHATDLQLGSDTNEAENDGQARRQLIDDPLVPGVQPVSEAMRHLYRQSSPHMDEYMTSSEDKLDPLSVERPLSHAITFNSDAEAEEQLKWEGFYQEPYVDQMPTGDLDDMAHTYRLTNRWHREAAAKKLLEELQATYGTKSRRFDYQKMGDVLEINNARVQPKGFPVLARGMKPIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTD6</accession>
    <name>A0A088RTD6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-beta-lactamase family protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_230690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699226.1">
        <property type="nucleotide sequence ID" value="XM_010700924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTD6"/>
    <dbReference type="GeneID" id="22575273"/>
    <dbReference type="KEGG" id="lpan:LPMP_230690"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230013900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_230690"/>
    <dbReference type="eggNOG" id="ENOG502R1JV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="515692at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="CDD" id="cd06262">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42773:SF1">
        <property type="entry name" value="METALLO-BETA-LACTAMASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42773">
        <property type="entry name" value="METALLO-BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="89"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="366" mass="41539" checksum="405AD653B87AEB99" modified="2014-11-26" version="1">MLSLCRPPLLPHRGRGLLRPNDLLRCTFQPNLTSLTNQVNRNEYFLKFGNKNIPIGVPRVSRRDVRPISTLHETPHLLVAGRNYANGFAGNQFLLVQKEKKECIFVDAADDWPDDWVSFIATSGLRPTHFFLTHCHVDCIVNLNAFLAVMEQHFHARLGLMWCPAEQSWVDAFPRACERYGRIEEMRQPLPLLRNSLYSYYTYANQLGQRKDALNVAAGGRGSPSPPVLPRQLVRSNDILLSSATNRSTSFYEFGPHSLLHYVFTPGHSPGHMMLSLPRERLLFTGDVLFYNGVGRVDLPWGSGERLAESLLTLEGYPDNTVLLPAHGRLTTLGRERRENRALRVLYERRAAGDQRVSIGYNTGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTH2</accession>
    <name>A0A088RTH2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">beta-fructofuranosidase</fullName>
            <ecNumber evidence="2">3.2.1.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_231040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.26" evidence="2"/>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699261.1">
        <property type="nucleotide sequence ID" value="XM_010700959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTH2"/>
    <dbReference type="GeneID" id="22575309"/>
    <dbReference type="KEGG" id="lpan:LPMP_231040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230017100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_231040"/>
    <dbReference type="eggNOG" id="KOG0228">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="202537at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004564">
        <property type="term" value="F:beta-fructofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18623">
        <property type="entry name" value="GH32_ScrB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051214">
        <property type="entry name" value="GH32_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43101">
        <property type="entry name" value="BETA-FRUCTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43101:SF1">
        <property type="entry name" value="BETA-FRUCTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 C-terminal" evidence="7">
        <location>
            <begin position="361"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN98554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="486" mass="55215" checksum="C0531DB125E87FC2" modified="2014-11-26" version="1">MNNPTGLVYFRGSYHVFYQYHPYSSTWGPMHWGHFTSEDLVHWKREKTALAPGDACDRDGCFSGSAIVHEDKMYIVYTGNFALDKAMPSKPDAIYEQQCVAVSSDGVNFEKLGVVVRPPPGYVHFRDPKVWQQDGRWWMVCGARDVTKDLGQLLLFTTQDLLCWDDTNWQVLGMTEDKNVFMWECPDFFQLDQRDVFVYSPQGMRKVGYANRNRFQSGYLLGSWDTSLVEPAPPQVKGEAPRDPADRGRAIGGPRWLTSFDVTQRFRELDRGHDFYAPQTLSTVDGRQLIIGWMDMWESPMPTREHGWSGCLTLPRELRYNAATGQLQMLPAQELVGLRTSEGTTLPYLLVGSNNDALIIEECTAYELDIAFNTETSTAEKYGLWLGSGAELYVDAQSKRLVLNRHYPQYMLSGYRSCEMPAGVLLQLHVFIDRSSIEVFVNNGEVTFSSRVFPEEGDRALRVFSVNGVADMAGGTMWKLETTVKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTI5</accession>
    <name>A0A088RTI5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein S16, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_260860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699907.1">
        <property type="nucleotide sequence ID" value="XM_010701605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTI5"/>
    <dbReference type="GeneID" id="22575989"/>
    <dbReference type="KEGG" id="lpan:LPMP_260860"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000027800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_260860"/>
    <dbReference type="eggNOG" id="KOG1753">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="259783at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000093">
        <property type="entry name" value="40S ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN99200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="149" mass="16695" checksum="9201CCFB801EC9AD" modified="2014-11-26" version="1">MPADKNYALKQVQTFGKKKTAIAVATVTKASQCSIKVNGVPLQQILPDTLRAKIMEAVTVVGSKCYSRLRIDVTVRGGGQVSQAYAARQSIAKGLIAFFQKYHNEVEKAALKDKFLAYDKFLLIADPRRCEPKKWGRHSARTRFTKSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RU13</accession>
    <name>A0A088RU13_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="9">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_271330</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="9">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="9"/>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700220.1">
        <property type="nucleotide sequence ID" value="XM_010701918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RU13"/>
    <dbReference type="GeneID" id="22576311"/>
    <dbReference type="KEGG" id="lpan:LPMP_271330"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270020300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_271330"/>
    <dbReference type="eggNOG" id="ENOG502S1WY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002430">
        <property type="entry name" value="Zinc finger protein family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041367">
        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="126"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="8">
        <location>
            <begin position="126"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="62"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="492"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="81"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="510"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN99513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="529" mass="60137" checksum="DA8D32D751CE6C9D" modified="2014-11-26" version="1">MSQQNAVEALLARLQMGDAIPAFQAMGVDRIVSLRKMSEDALRQAVPDAEQRQALMNAIESRGHLQSRRVGPPADQPHPPRSADAEFARSGNDESRSGYAPRGDRDDRVARGGRGGGRSTGAPNSDDATRLCRHVFTTDGCKFGQKCRYSHGGNDYRRLQEVLMDSGVAQRSLDRPPQNFKFSIDVEIPTERIKYLLGPQGINMRFINETCGTYNERFAHVDETEDTFTIHLLGGSEEAVNKAKEMLLMSVGVKREEEKKDRFQYAVNELDANTHAARLFAACNTKNKGTTRHLSDSIMRNIVSSFNFVRPQEVRHFYMYTSCSDKDKLEMVSKIVSQLKGVQAILFCDQKRVEEMCKGSQRIARHFNRVNPQFVYRRLSKEDRMIALDKFKKGVVNENGVLERLLVTNEDYAKLARKTVIPYVNLVINFSVPRAEEYYVLQSQVAGRQGTIGASFLCVSNYEEALFRELEKNIHFERFEDEDDFRSTAVELSYDTDAQPLTPEDADPPADWREHLNDRKPPQSFGKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RU38</accession>
    <name>A0A088RU38_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">AAT24</name>
        <name evidence="8" type="ORF">LPMP_271580</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700245.1">
        <property type="nucleotide sequence ID" value="XM_010701943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RU38"/>
    <dbReference type="GeneID" id="22576336"/>
    <dbReference type="KEGG" id="lpan:LPMP_271580"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270022900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_271580"/>
    <dbReference type="eggNOG" id="KOG1305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28208at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF649">
        <property type="entry name" value="ACID TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="76"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN99538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="480" mass="52812" checksum="50562CC14708B3C9" modified="2014-11-26" version="1">MAKRTHSPGPQMSPVSEGRESLTDDAMELNRMGEIQMKDVVCSPNTPDVDALVYTATHQPRNCFTAMLRKAVPHGGMLSNSYNLAAVTLGSGVIALPSAFRAMGMITSILTLLIITLSTVYSVYIMIQAADKTGRRLYSYEALARGLLGRGWDYLAAFHMWMFCFGSCVSYVISTGNLLSRATDDPSVNSFVRSPWGNRLLVAMIWACVMLPLSIPKTINSLRYFSIIGVTCMMNFVIVIVAHSAMNGFENGRPIHQPKMFKTGNSAVVGFSSILFAFLAQTNVFEVARETPKPTPWRISRDIAISQVVCCALYVLAGVFGYLEFGEQITDSILLYYNVRRDVLVMIAYVGIAVKMCVGFALCMQPSRDAVYYCLGWHFPTFKDIRTVPFWLNAVICTGFSLLALVLGLFIPSVNIVFGLVGSFSGGFLGFIFPALYIMYAGNWGLRQVGWVHYLSTYLLLIAGVVAVVFGTVASIYEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUH0</accession>
    <name>A0A088RUH0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ABCB1</name>
        <name evidence="10" type="ORF">LPMP_250540</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699626.1">
        <property type="nucleotide sequence ID" value="XM_010701324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUH0"/>
    <dbReference type="GeneID" id="22575702"/>
    <dbReference type="KEGG" id="lpan:LPMP_250540"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250010200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_250540"/>
    <dbReference type="eggNOG" id="KOG0058">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18573">
        <property type="entry name" value="ABC_6TM_ABCB10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000261">
        <property type="entry name" value="ABC transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001797">
        <property type="entry name" value="ABC transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000355">
        <property type="entry name" value="Putative ATP-binding cassette protein subfamily B,member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="76"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="394"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN98919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="656" mass="71845" checksum="81136469F4FD5563" modified="2014-11-26" version="1">MRSSSRLVWQPVSCTTLTSLRRLASDIRLRTDYGKATPAQRPTTSKSPIYVTEPATRKGSFARYVRSAQDQAPYIAGAVVGVCIYSAATLAIPAGFGALIDSASKGQMPLGTSMQLLGWFGLCAVGNYLRLYCIGYAGESIIAKLRHTLYSGILRQPTAFFDSTENRTGALVQRLAMDCNVVGSSLTEAVTNGTKNLFQTMGSVTVMLYYSPLLTSVIVCMIPPVAIFAGSYGRYIRKLQHHMQDALADMGTVAEERLSNIRTVRSFGTEVQEESWYGRNVQRVFDLSMRMVRWNSVYVASLQTVGYGAMYCIMWAGSMLVTSGQLTPGVLFSFLLYTVYCGMGLMGLTNLVTEINKGYGASLRLFDILDKSETMQQEQMACKQLTPVPCDWRVTLKDVSFAYPTRPEVFVYKNINLSIEPSRCTCVVGSSGSGKSSLAMLLLKLYEPTAGLVQLGGHDLRDISSQWLHEQIGYVGQEPVLFGGSIAQNIAYGMPGRNWDDVIDRWLYLTIVTAAQKANAHDFISALPDGYDTFVGENGRSLSGGQKQRIAIARALLRNPHITILDEATSALDSESEVVVQDAISRLIEEAKGSKRQHTVLMFAHKLSMIRKADHIIVLDKGQVAVEGTFAEVSTNKLFCDIVGLAATSPRKTGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUL9</accession>
    <name>A0A088RUL9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Threonylcarbamoyl-AMP synthase</fullName>
            <shortName evidence="13">TC-AMP synthase</shortName>
            <ecNumber evidence="3 13">2.7.7.87</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 13">L-threonylcarbamoyladenylate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LPMP_282190</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the SUA5 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="3 13"/>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700559.1">
        <property type="nucleotide sequence ID" value="XM_010702257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUL9"/>
    <dbReference type="GeneID" id="22576664"/>
    <dbReference type="KEGG" id="lpan:LPMP_282190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280028200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_282190"/>
    <dbReference type="eggNOG" id="KOG3051">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="412787at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000009">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11030">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="Sua5-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038385">
        <property type="entry name" value="Sua5/YwlC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005145">
        <property type="entry name" value="Sua5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010923">
        <property type="entry name" value="T(6)A37_SUA5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050156">
        <property type="entry name" value="TC-AMP_synthase_SUA5"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00057">
        <property type="entry name" value="L-threonylcarbamoyladenylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490">
        <property type="entry name" value="SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490:SF16">
        <property type="entry name" value="THREONYLCARBAMOYL-AMP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03481">
        <property type="entry name" value="Sua5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004930">
        <property type="entry name" value="Tln_factor_SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="YrdC-like" evidence="15">
        <location>
            <begin position="9"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR004930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR004930-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AIN99852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="382" mass="41019" checksum="9285692F009B463E" modified="2014-11-26" version="1">MAQIIGISLEDLRRAADALLEGKLVAIPTETVYGLGGNALIESAAKRIYTVKGRPPTDPLICHVCNLDGVRRLWDLKWDEEAVELACAIGAALWPGPLTIVFKANPSLPDCVTGGSGYVGARIPNNAITLKLLEMVDVPVAAPSANTFGHVSPTTAQHVYDDLAARDPELLIIDGGQSSVGIESTVAKVESKDLVVVLRRGCITVSMIHRAIAERYPQTRVEVRDMRIMCGSMTAPMESPGQLLTHYSPRVPSSLLTPGSLAMLTASAGVPVYVHRGKDVVPLSETIVLDFDGYLSRFRDSCLSYHDMSPDGNPEEGCFAVFDALRATETVKGAKSLVFPFISEWPHDKENEDLLAAMEDRLFRAASGVTAVLINEVAPASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUT9</accession>
    <name>A0A088RUT9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_272570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99635.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700342.1">
        <property type="nucleotide sequence ID" value="XM_010702040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUT9"/>
    <dbReference type="GeneID" id="22576434"/>
    <dbReference type="KEGG" id="lpan:LPMP_272570"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270033700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_272570"/>
    <dbReference type="eggNOG" id="ENOG502S67Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273844at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99635.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="440" mass="47546" checksum="8E166BB2C1D88A66" modified="2026-01-28" version="2">MQHRTRPRPAPSSTEASPPSLKRQDAATRSAQLTSLFDRPSGPVPKVRQGAHLSEDCADGLTGEGVKGVLSPTLLSRRLLPSTSAPLSHPAGGISSSSTGGAVLRSGGVPVLPTNSCGLPHFFSEQSRAVLSVEITSAEIQRTLQQLHHDLDFHAKRRIEAGRDAGCYLASAPRFHPSADSTSVTLLTGEVTDTQQRRMVEVDTLSEAANIQRARAAAADEGASDDQSVEDYGVDCEVPPLTSDSRLADEVAAIAVCLAKMKESAGVMYDTEAAASSTSVAPWWSSALGMRDMKVSVARLDYHAHSALSWSHRSREQLLLQAVMLNNASAATREQLFQQQNRLQEFQARLSDGQQAATQLQADIAQYQARVQAEMARRAALQEELRLCAQERGLVDPAERNPLKAELALLLEEREWPSHTLKRDASVVLGWLHSVSTALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RV29</accession>
    <name>A0A088RV29_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_290670</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700675.1">
        <property type="nucleotide sequence ID" value="XM_010702373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RV29"/>
    <dbReference type="GeneID" id="22576831"/>
    <dbReference type="KEGG" id="lpan:LPMP_290670"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290010800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_290670"/>
    <dbReference type="eggNOG" id="ENOG502QW9C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001039">
        <property type="entry name" value="Putative RNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="204"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="483"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="625"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="643"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="653"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="707"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO00018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="734" mass="77381" checksum="55B1CCCBABD29722" modified="2014-11-26" version="1">MHLAGGRGSFQSRGGGRGGSAAAAHKSAPAPVKRSVVPAFPVIARGTEPVAPKTPSAHLTSRQPTKQRQGLQGSPSMHDDGDDAPPVVMSARRGAAKEENGGFIPPSSPPLQRGRGRGDGRGGFRGGTSAPSSVFSSSGRGYGGSPHPLRRGGHDHTASRHGEEEYNSDEEAGFNSSAAKGGGLTRVITTVTASGTELPKKLNTKVFIDGLPYTYATEPGKPTLEEEVLQFASAWKVGKPLRLIKKPGQGFGFLVLQSPNSVSTAVRVLNGRKFLGRTLRVEEPKPKDLEKIKDIAGMKDMGKDSFTRQVLLTDLAKVAQPEIIREVLRDVAPQLEKKLEAIKMTSQNRKAFLTFATEAEVAPAITFLDGFHLLGRRISATKAAAPGSLPYSHGAARPSCTAGGLVGRSAAVASPAARGSVAAEAEDDEELAIMPLGLEPAKVASAATRRCMPAENASALATGTGSNVTGRTEKYNLLDDGPKDIYVGNVGEDVTEVQLRQHFAPCGAIRKCEILVHPETHLSTGIARVEFALPAYAAYAQERYHGSRLRGCVLRVDRGGTASAPLVAELPPAEAEDDYDEEAYMERYGVKDKRKYFKGTSLAAEMGADPNADGDDSDIEDALLGRDANASEKMKGKRRRGDATAAAPGPAAAKRKRTEASASRRKPVAAAAVANRSDDEDDEEHFFDADTVPVAAAEVSARGSFYSSSKKVAKKSAAAKGRPGKGNVKKAKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVI8</accession>
    <name>A0A088RVI8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_261560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699976.1">
        <property type="nucleotide sequence ID" value="XM_010701674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVI8"/>
    <dbReference type="GeneID" id="22576059"/>
    <dbReference type="KEGG" id="lpan:LPMP_261560"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260021100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_261560"/>
    <dbReference type="eggNOG" id="ENOG502S8RV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271060at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="585" mass="64458" checksum="F6604E013D28CF28" modified="2014-11-26" version="1">MEFSSSSSSDAELEEELHRNFHREQREQRGIVRASSSPNSYQTMSFPMPDGRSIEVRKGSIYIPLRDMYVHVLQARRCPERWFGDGRVPLRRRRPLPADVVVLQRVTEAAAAGRGGSTRPLVSVTLREATDNDFFIFKEVRPRKAEGDAGEVAAPIIRIAPFTPQKRQNSWHDPLTDTRFQRVTFLSRWHFSMAYPRLLREYRYDTWDTIELSPPLHVEDVCCYDDLLGILWCLSGRDGRLCYLRYDDNAVTTTRSTALTSVCVTTVDVTTAQRCVGIYCKHEGSPSYDAAGGDYQEANSCVCCLLVVTASHALCVRLVYTWGNKFTVDHVLSTLKVVSVLSKPLQLANVTCCCPGNAEKPPGVPLSSSTNDTSFCVGAGRSVFAFIWRNGQWRRVRLASFVATDVTALTLHAAFGHSSLPVAVVAGMRNGTIQVVTAEGRLHNKVIFDPTPRHCGSDITSMYAVPGLAYGVVSVARDGGAKLWDLRRLGSDKNPVCTLLTSRLGGGQSGVGSTAMAGHLLAVSSVSTGLVCVDAQTGTQLLHTTKKLSPATRIAFGSLSNVDDNDGFELYTFSPHYTQRFHLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVJ7</accession>
    <name>A0A088RVJ7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_261720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699991.1">
        <property type="nucleotide sequence ID" value="XM_010701689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVJ7"/>
    <dbReference type="GeneID" id="22576075"/>
    <dbReference type="KEGG" id="lpan:LPMP_261720"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230028300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_261720"/>
    <dbReference type="eggNOG" id="ENOG502SUES">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="241817at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="CDD" id="cd12084">
        <property type="entry name" value="DD_RII_PKA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="142" mass="15503" checksum="562D79D7961BB765" modified="2014-11-26" version="1">MSAYHEIIEADKVYLEEVGMRDILQQFVADAMESHPVNVYEYMITWATKRQASSIPSPKGVAHRGDEEKCPIGGEEEEEGAAAKTQAEEEPGARDHEQHHFSSNKSSPSGAHSLNRASSVNSKAFSPVAAAKSERTEGEEGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVY1</accession>
    <name>A0A088RVY1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_270520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700141.1">
        <property type="nucleotide sequence ID" value="XM_010701839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVY1"/>
    <dbReference type="GeneID" id="22576228"/>
    <dbReference type="KEGG" id="lpan:LPMP_270520"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270012000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_270520"/>
    <dbReference type="eggNOG" id="ENOG502SBF3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="244442at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="376"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="584" mass="64312" checksum="84019E24E4A8A4A5" modified="2014-11-26" version="1">MQSTSVTAALQDALEKGDIVELEQAITAAEDAIHVSAYARKTSCSPLGTLIARAKQMHHLHMKACKSYVEPLRKACRELSERGIFEALVKARGAPDEVQLCMYTDLCNAESLRREITEAQRLGVRLLDSTSAQEVDDFLTECSPFLEDRTILALVQKREDLLREERRRKIGGEPTTPLRAGATNCARNAAWRDHDPLESLSHFEREKEGALPGAGRYKQLIYRSSSNGGRAGRKGVSEEVAGSSAGARGAYPALCDALEKAHDSDLERTIMEGSSPWMQTIRALLQQGCEKMMCQEHSTRRQLESAEEDGRAEVYRSEMLSRVQRWTAAAAVFSAFHGEKQVEPKSDRGNGVTPWRASLFHTRASPSLSRAPMPSSPAHASQAATEAAHPANRPLPPVYAMHSPPAYTFRPGERQRTPTRSPCVDTEAAAEGPILGSAVHHRVVEELHTPHMFRDTPNISPIKEISTASGAASLPEQDQVDRRSSTKPGGGDRPERGTPRGGVSEDSASAAAATLVWSPRTAAVLPSLELRRIQARLRAVLQEEDIHRRDIEGTEDFDRSVFLFPVSARIALLQRTEAQRRRTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RW95</accession>
    <name>A0A088RW95_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_292090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700813.1">
        <property type="nucleotide sequence ID" value="XM_010702511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RW95"/>
    <dbReference type="GeneID" id="22576972"/>
    <dbReference type="KEGG" id="lpan:LPMP_292090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290023100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_292090"/>
    <dbReference type="eggNOG" id="ENOG502SIXM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267153at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="419" mass="44458" checksum="F56DCF823FBC7B12" modified="2014-11-26" version="1">MAQLPALVSTEATRKRELGTAHTPPLKLLSGKSTAHRSSLLPQLSVTTASSLRPARVKSTMAAGVAAPTTVSAESPVCRSTDPAAPLPLLSQLLRISVPAASSTLVQTPEEVTVKEAMEALGELDAVEVLFVHLNHMAHSNYSSDDGAFADAIAVVEGHAAAVMDEIGESDARAIPPARADCHAATTTPTVAHQRRSWADSPNAVLVSRRSYLPCLVLCVQCHRGVLALHIVNLRFEGASGKSHCALRAATLDREGQQKKDSSGETQRRQRRTTVKPQRLQPSYRNERASTTAVGGVPSSLPPSPSNDEGVVEATGVGELASVSSDLVETVPSLFPVARADATGHRASVASPKHSQRPWKGKSGLRQRSSTMKAAHHSITRSSATAVSFDPFRPEETTPFNAQYRPITYNAAIVLQSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWJ4</accession>
    <name>A0A088RWJ4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Vesicle-associated membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_272400</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700326.1">
        <property type="nucleotide sequence ID" value="XM_010702024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWJ4"/>
    <dbReference type="GeneID" id="22576418"/>
    <dbReference type="KEGG" id="lpan:LPMP_272400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270031900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_272400"/>
    <dbReference type="eggNOG" id="KOG0859">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="248747at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15843">
        <property type="entry name" value="R-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051097">
        <property type="entry name" value="Synaptobrevin-like_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136">
        <property type="entry name" value="SNARE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136:SF168">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="10">
        <location>
            <begin position="34"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="129"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN99619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="220" mass="24796" checksum="85BF8A390B57ABC3" modified="2014-11-26" version="1">MPINSSLVAFEWTIIAEDSVSPSAGPVLQKMLSLLPRHDTKVSYQLEQEVFHFLVENEIIYGCTTSGHYENRIVFGFLIQIKDAFKMAFAGRAEECLRHADLTPENCHTFSSTLASSRKAFNENTQEDKVSQIKEQLNTTREVILQNLDSIIERGDRIDTLCDRTELLRDTAQGFHTNARALNRTILMHRIKVIVGVTIVLAILALIITLAVCGIDFKKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYB4</accession>
    <name>A0A088RYB4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="8">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">QSOX</name>
        <name evidence="11" type="ORF">LPMP_300450</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 8">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="8"/>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701080.1">
        <property type="nucleotide sequence ID" value="XM_010702778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYB4"/>
    <dbReference type="GeneID" id="22577099"/>
    <dbReference type="KEGG" id="lpan:LPMP_300450"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300009800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_300450"/>
    <dbReference type="eggNOG" id="KOG1731">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="59470at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.310:FF:000010">
        <property type="entry name" value="Sulfhydryl oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053995">
        <property type="entry name" value="QSOX_pErv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039798">
        <property type="entry name" value="Sulfhydryl_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22897">
        <property type="entry name" value="QUIESCIN Q6-RELATED SULFHYDRYL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22897:SF8">
        <property type="entry name" value="SULFHYDRYL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22220">
        <property type="entry name" value="QSOX_pErv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8" id="KW-0274">FAD</keyword>
    <keyword evidence="2 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839122" description="Sulfhydryl oxidase" evidence="9">
        <location>
            <begin position="27"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="514"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="10">
        <location>
            <begin position="341"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIO00280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="554" mass="61967" checksum="343B5A40BA8FC625" modified="2014-11-26" version="1">MTLLPRLAATALSLWFLAVLCCPGRATFLSQSHSLFLDAFEVIDIHDTRLGGLHESAHMCPWILVAYSGGCGHCRLSAPDISRLAKETTEDSGDVLNEVTVAALNCETSTEECRRLQVHAVPSLYLLLPLNMSTKESTLAPVIANKKDVDEGVAEARPITMTRVLLGQGGYIKEHFDTARKVWGSASASLWAATSKERCLHMRSYLRNLKVSDAAEAGAGVGPSAAGATKFVEDTTFHMVDIANAFLETLYHEVALIGLESAARRRALLQFLRVVQQRLPGLGADVLLYSMAANRSVDNMQYSVDDFASVSVADWQKLVLSAGIPYQGTPRHLRWQTCKGSSWRYRGFPCGMWLLYHALTVNVVHADADNNNAEVLFIILDYARNFFSCDACRTHFLRFQPEKDKDPVLQLWRFHNEVNRRLAEVKEGADPLVRKRIFPDPRQCPACYRDAVTSNDEERFVVTEVSQYLRSHYKWVPTALYETTGTETLPLTRRAANHHGEAITAYRDPLSMNAFLTIVFPATVVVLGMIYVLRRARRSGTKRRRPILPLRAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYF3</accession>
    <name>A0A088RYF3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L18a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_320940</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO00981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701781.1">
        <property type="nucleotide sequence ID" value="XM_010703479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYF3"/>
    <dbReference type="GeneID" id="22577835"/>
    <dbReference type="KEGG" id="lpan:LPMP_320940"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320014400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_320940"/>
    <dbReference type="eggNOG" id="KOG0829">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275759at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000010">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000013">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00273">
        <property type="entry name" value="Ribosomal_eL20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028877">
        <property type="entry name" value="Ribosomal_eL20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023573">
        <property type="entry name" value="Ribosomal_eL20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021138">
        <property type="entry name" value="Ribosomal_eL20_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10052">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01775">
        <property type="entry name" value="Ribosomal_L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002190">
        <property type="entry name" value="Ribosomal_L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160374">
        <property type="entry name" value="RplX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL20" evidence="5">
        <location>
            <begin position="7"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO00981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="179" mass="20738" checksum="1F223F7F62F3A76A" modified="2014-11-26" version="1">MVKPHLRHYQVVGRESPSEKNPEPTVYKFEVFAPNFVVAKSRFWRMMKIKNKVKATHGDVLSCKVVKDAKLVARNYLVDIAYYSQRCGYTRMVKEFRDVSKTGAVSQAYHDLASRHRARYHNIEVLCVKSIPDHEVKHLSIAQYHAPNLSFPLLQRRSKAARKDRAIFVKKNTKRAVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYY1</accession>
    <name>A0A088RYY1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Guanine-nucleotide-exchange factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_322890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701974.1">
        <property type="nucleotide sequence ID" value="XM_010703672.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22578030"/>
    <dbReference type="KEGG" id="lpan:LPMP_322890"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320035200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_322890"/>
    <dbReference type="eggNOG" id="ENOG502SMTP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="430364at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF391">
        <property type="entry name" value="SEC7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="2">
        <location>
            <begin position="939"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="867"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1178"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="885"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1183"/>
            <end position="1194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1444" mass="157878" checksum="274EC2ADBB96F9C0" modified="2014-11-26" version="1">MGPAPPPELVRRTIEACRVVLQEVRRSVDSTVTNAAVKAELRRGVSAAESALNTAEQLLTAPLHRSGASRRTSASAPTLHVREDTVTLSATTVAQLATNAVGSPVLQSSIASRDDNTSREERHLSNSSLRGGGTVSATRPVGTAIDPAGSPQLCTTLQDAVIWSYLLSTFFWKRRKLTKCSITALELLLRVVPVPSEAVTLIVDLATMGPEGNAGGDGVLEGGPVSRRSSHVRLYVAACVYYALSECVLQSFSEPAVQIRALRLLSELITRIPGSPRWSGVGAGSAGHEVEANGSIVRSSESVTVDMVTCFRGRIAMRVVESCFKAAAEGMQDSVRCEGRVALHAAVQRVVYNFVKMRMYNGKVSDPDGCAEARAAFSTDTILSDYTVDVDSNEPYTRINFVPSDKAEVRLPTGVLTGALPIIPAATAATLHVSGQTCSVAATKLRRDEEGGSKSGREPTAAPSPLSVEQLRCSGDENSGVVCVSDARAPSPMHLVSRETPTLSAQLISEGSCLNEGDSGLLQSPAQSQPPGTAAANIATSSLLDVPPSPPPLNLSFDPHKFFPNSVDESLVLDALSTLNTADGALPSSLKDLLMVLRRMCRHASHPCSGTLSDANNDVRARDLGLRVLECVLDGLPVANCEREHRCAKWMSLVLHACKYELLGCIVKNLAMATPFTLFERAVHLLGMLLRKLHYHMARELHTLLGAFLLPLMASQYAGFRQKYVVLSMIKQLFAVPHLCIAFFINYDCSPAFDPGAEYGGMLELLVEYVVKMTFLDHVDENGDVYPWLSFDQQQLLRSECVVVICTLMASLYRWIAEDPREYAESLLCNTQKDAPQRQQQGGGGTIGATESSELYVVNLEADAGVDPHPPLTGDHSATAAANGKEGKEGSDNPGESKFDNRKVALTLSALSGMTLPHWNKCHNVMYHWKHIHYLLHDKRILQEAVQRINAGRWREAKEFLESRGFTTALAPSAGERADPTSVVTGTSSYALFARFLFEYPGISREALSAIFEKVNQKDGASRMLLLEYLHCFDYKDVPIDVALRDTTCKFMSWERPTFEAKVWETIQECFGNEYANQNPHSITARDADAMSGVLLFLHSNLHNVLMKNERMQMSQFVRDANDCLEFPMMVEDLRAIFNRVLQCKWELDTYGRTPQEAGRERTLVRLSTKIKMVRAAQQRRQSTANNNTSITNSKGSTVSRGLSPGGGGGAGAVATAATTSKGSLIVDADPEVLYDVLQGTEENDDNLGHTFFSVPGSTAARMIPKAAAVPSPSASLDGRTLQMWSSDDMALLDNTIPAYAEMKDGLKTKEPQHHAFHEAAAVYLQKLESVHRVYCIEGGVYRPQPYISPYYAEHVRQILLLTYPHVMSCVYMGFRVLEEAPISRKLLDTVQVTYDIAAAFVLNLHDLRPAMEEALQRYLDDKRVYRLLPQSRATFVPFFLNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZ69</accession>
    <name>A0A088RZ69_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">60S acidic ribosomal protein P2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LIP1</name>
        <name evidence="9" type="synonym">LIP2</name>
        <name evidence="8" type="ORF">LPMP_303680</name>
        <name evidence="9" type="ORF">LPMP_303690</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an important role in the elongation step of protein synthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">P1 and P2 exist as dimers at the large ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701390.1">
        <property type="nucleotide sequence ID" value="XM_010703088.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701391.1">
        <property type="nucleotide sequence ID" value="XM_010703089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZ69"/>
    <dbReference type="GeneID" id="22577421"/>
    <dbReference type="GeneID" id="22577422"/>
    <dbReference type="KEGG" id="lpan:LPMP_303680"/>
    <dbReference type="KEGG" id="lpan:LPMP_303690"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300042000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_303680"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_303690"/>
    <dbReference type="eggNOG" id="KOG3449">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267125at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002182">
        <property type="term" value="P:cytoplasmic translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05833">
        <property type="entry name" value="Ribosomal_P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001859">
        <property type="entry name" value="Ribosomal_P1/P2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044076">
        <property type="entry name" value="Ribosomal_P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141:SF58">
        <property type="entry name" value="ACIDIC RIBOSOMAL PROTEIN P2, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00456">
        <property type="entry name" value="RIBOSOMALP2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO00590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIO00591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="105" mass="10547" checksum="4D5ADA2F2B10A0AE" modified="2014-11-26" version="1">MQYLAAYALVALSGKTPCKADVQAVLKAAGVAVDLCRVDALFQELEGKSFDGLMTEGRSKLVGSGSAAPAAAASTAGAAVATAADAKKEASEEEADDDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZB6</accession>
    <name>A0A088RZB6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_323950</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702076.1">
        <property type="nucleotide sequence ID" value="XM_010703774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZB6"/>
    <dbReference type="GeneID" id="22578136"/>
    <dbReference type="KEGG" id="lpan:LPMP_323950"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320046800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_323950"/>
    <dbReference type="eggNOG" id="ENOG502QQ51">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276661at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037867">
        <property type="entry name" value="Swd2/WDR82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861">
        <property type="entry name" value="WD40 REPEAT PROTEIN SWD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO01276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="359" mass="39225" checksum="C97DE38A9A666B78" modified="2014-11-26" version="1">MFYTGINEPRPTSMNFSFDGLHFVSAHTDDAVRLIDVGNMTNTDVIICDAFGVHNVRYTHSSSVVCVAPRFHLDGHLHLLNTETSQFFGEMAYLNDAESEILPVANTPVYSTLAQCPATDVIGAVVAAKGRLALFHPLISGCIAATPERSIVGSRVCVQFSLDGHRIAIGDDHRITLLDRRNLFQAPHVVLENKRVFTTSASLTRCKGLEFSADASRLLLTSSSGEVVVYDWQRDETVVNYFHGDAKRHFLGSADAIGAQYVFPYQTASPILQLTSSMTGGRHLLVYAGCHSNSVYPTRHGRLLYELQSKDSDVPVAVAVNPRLQLAATAARSITWWAFHSSVVEAYARPTQAGTIAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZD4</accession>
    <name>A0A088RZD4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_330760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702169.1">
        <property type="nucleotide sequence ID" value="XM_010703867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZD4"/>
    <dbReference type="GeneID" id="22578229"/>
    <dbReference type="KEGG" id="lpan:LPMP_330760"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330012200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_330760"/>
    <dbReference type="eggNOG" id="KOG1237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="205993at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="491"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="538"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="577"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="603"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO01369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="628" mass="67948" checksum="4AD494FB01A4DD69" modified="2014-11-26" version="1">MRLFLELPSAVWAVLAIEFLERLGYYAVALSLFTYCTVMLQTGPAAANALINIVYILVPAAALLASGVADSRVGRSRVLAIALAAYTASLLLLCVSATPWLYTSFPLGAQWSSKALFAVALVGFSAGYGSMKVCINPIMADCVTLHYRTAFIGLPTIVDSWEARAEMNAVSVVKAAKLPTREMASLSGATRKGVVANATGAASEASSHDVSSYDSITETDTATSLYEKEHVTTALSRLFVYTYWVGNVGGLVGSFVAPLLRNFESRRLVQGSEEYTTGYYYSFLLAALSVGLGGGFLYWCFAWLPSNAPAPKFVLIRVIMLALQNRWAVMRGSVRVVPGTRDGISEPQDWLDYACVRLHPTSSGTGGISANHAVLADAAAAFECSTSTVYGSSCSSTLDDVDGDASNTSLWVADCRTTLRACKAFIALPIYWLICNQFSTNLMYQAEALDMPVSVPKELFNNINTATMLLFLALWDLWLLPRVLLHRVPSACLRIMAGFGCMCASMLWCGFLQCTLTDCGYYEGEDSYVLRDGQRKLSAGWLIVPYILQGLASAFVDPTVMEVAYRDTPERMKGTVMGLYWFASSASGFLGFALSPVMKPQNAAPLFFSFAVAQMVVAALFYRANSGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZP5</accession>
    <name>A0A088RZP5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Trypsin-like cysteine/serine peptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_333240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702413.1">
        <property type="nucleotide sequence ID" value="XM_010704111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZP5"/>
    <dbReference type="GeneID" id="22578477"/>
    <dbReference type="KEGG" id="lpan:LPMP_333240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330040800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_333240"/>
    <dbReference type="eggNOG" id="ENOG502S06M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="240599at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO01613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="33049" checksum="910DDE943956934B" modified="2014-11-26" version="1">MAEGNATAVGTGALATASLRRGCCVPILSFLHVPGKMLKPLWLMMGTAFRFRTRRMIKAASGKPAASPSVLLLTAKHSFAPWNYTKDASQLKIPQEYQKARFVICRMYRTDEDGRAVATDAVSLRLLAQHPNLDVALLAVDAASWKAPHRATAEAPTHTLDLAPESLLLCEELYPAASDGLLIGFRGVGRLGELDTLDPSVLQRLPPHERDALLKEMQDVEGKQIRATATVSVLDAQGMCKGVGDLATCYHGMSGSPLVTTAGQCAGVLYGHHPDAPGCIGYTPCADFADWLENEVQLYTKRRNSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZQ7</accession>
    <name>A0A088RZQ7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="2">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_332030</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="2"/>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702294.1">
        <property type="nucleotide sequence ID" value="XM_010703992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZQ7"/>
    <dbReference type="GeneID" id="22578356"/>
    <dbReference type="KEGG" id="lpan:LPMP_332030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330027400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_332030"/>
    <dbReference type="eggNOG" id="KOG1448">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000002">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000014">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002320">
        <property type="entry name" value="PRK01259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF119">
        <property type="entry name" value="SYNTHETASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="11">
        <location>
            <begin position="36"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIO01494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="356" mass="39039" checksum="5361DE915B540874" modified="2014-11-26" version="1">MSANTPQHHKGHQVAAGETFFYRHHVRPGVETAFRIRLISGTANPDLTDNVAKCLNVDKCRTEIKRFANGELNIKVVDNVRGDDCFIIQPTAGGFDTDVNTAMMELLLLVHTLKLSSAKRITAIVPYYAYSRQDRKSEPRVPISASAVAQLLQCMGVDRVVTMDLHCGQIQGFFRNIPVDNLLMFPEFATYLMRQPWFDKNETVVVSPDAGGVERANVLADRIGASHIVTILKRRKEAGVVDSMQTVGNVLGYTCVIIDDMVDTAGTLCKACDLLKEMGATRVIACASHGILTDPACTRINACEALEELVVSDSIDQRLKTARCDKLTVLTTAPLLAQAVHSLHKEASLSSLFVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0B5</accession>
    <name>A0A088S0B5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_342170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702643.1">
        <property type="nucleotide sequence ID" value="XM_010704341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0B5"/>
    <dbReference type="GeneID" id="22578722"/>
    <dbReference type="KEGG" id="lpan:LPMP_342170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340027600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_342170"/>
    <dbReference type="eggNOG" id="ENOG502SA7W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="261247at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="231" mass="24844" checksum="4E32B71D8E8CEEF5" modified="2014-11-26" version="1">MSLVTVMWCSCAKYTTLTSRLSCTATAASAKAAAAAKRGTLRAHSPQRCVCVGTGGSSLALFRPTRVARMLPQLARLLIAGSVALLQVFAVAYQRESRKLRQEEQARGAVGAAQDSTGMGSPRVMSAIEAMQLLGLDRDFPDLYISVQRAEASSASTSVSLPLAPGKAHRAARQNFERMFTLAIKEENMFLAGKLSAAYRICVDPRWDQTTSGEEDASDKSQHTIDDEGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0K1</accession>
    <name>A0A088S0K1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_340850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702511.1">
        <property type="nucleotide sequence ID" value="XM_010704209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0K1"/>
    <dbReference type="GeneID" id="22578589"/>
    <dbReference type="KEGG" id="lpan:LPMP_340850"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340014000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_340850"/>
    <dbReference type="eggNOG" id="ENOG502SK7V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273710at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="306" mass="32848" checksum="0F60F38EACF4B5B1" modified="2014-11-26" version="1">MDASVDVAARPVDHANSNRSSSFTLSLCLNQYLQWLGQLHSTIGTVSDYAYILGRLLRQGGFPLRQRTGVVPTATDARLRAAVCELLIGDVAVQSVRPPEAIWVTSARTTRSGYTAANFSSAASSPPLVHPEAPFCPCRAYFEEHKRGSGGRFLSLRRRSSQAKDNDKESHTGHAVTISSASGSNDESDNRAVHLSAAVPNFPASSKNAVRGVNNLGSRDRFSSRDVVTSGKIRVGSRPSDALSQPILLLPVAVVTPSSTASAEFGNDALQANSGRDAQCRKCVSPENSDFSPPSPIRTFPRARWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S120</accession>
    <name>A0A088S120_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Integral membrane bound transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_343430</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01969.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702769.1">
        <property type="nucleotide sequence ID" value="XM_010704467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S120"/>
    <dbReference type="GeneID" id="22578848"/>
    <dbReference type="KEGG" id="lpan:LPMP_343430"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340041100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_343430"/>
    <dbReference type="eggNOG" id="ENOG502R9GZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270705at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30509:SF38">
        <property type="entry name" value="FUSARIC ACID RESISTANCE PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30509">
        <property type="entry name" value="P-HYDROXYBENZOIC ACID EFFLUX PUMP SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO01969.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1190" mass="132722" checksum="DEA7D305A623EF80" modified="2026-01-28" version="2">MSHLFYSDEEPIFTSKEDASRDASLAVEAEPPPNTVTLANTSTSTKDHLASSNATTVEHQIKLSPRPLPLVAPDPGPPAECISANSPGAQPKAFSVHGAPSPIKAASDVPVAKLRGAANAGGAPGTRIANNTCCNGPSASNDADSLDSCGIPRYNVRYPEGGSGAHGDVSVPWHLRPSTRRMHCTFFDSLRAPQFWRQVEFAARITVLAVLVPSVLIAAKLPGSPFVSPFMVFSSTLLAAKRTPGEVIAYLVSWIRAGCFWLPLSVIAGALNLGHHITGWCIYYTAMLFIMGTFSEGIVRRICLLLFNTCAIGLLVDKNHGAIFPCRVMVDWCIGTGLCVVVAFFPYPLFCKNEAQQLLRDISRNTATAYRGLVYSFWSPSNVERNIAMSKVRIMTDSLDELMPLFEHYQSFSFYEWFFESAEVREIRALKFALLERLRLNLSSMTRVLDMVEAKPSAIDDSDSSRAFGELLNPHLNVVAEVFDKLLDLLTHAKTRKALLDLHERFEYFADRTDNLQDAYKLARRMIFYEYTSGVLEEFVPLMTFYLFTVVCVRDTIDIFQIKVKAHRPSVVGTIEQIWIKTAWEPLKENLNFLKKLVTEWNRREIQRVIEAAKVSGAMILTVGFSYLIKIDKAVFSGPSIIAFVSGANPVEAVQESIVRLTGCLLGTVLGFFAGTYSETPVQRIASLCTLMFVGTFLRFDKEYGVMAVYGMFVLIPLISIAETTVEDAVARMNQNTFGIFIYLFVSVLVLPLSPSLILRAKRSNVLRCMGSVVSNMMDLFSAPLANDPTVVDYSRMEHNETESEMSSKNVGDEKHPIPRRNTLTNRSLHLLSKADTAMLRIDAELVDLIRRLKGTKEMMKFARDERTLVDIDYPIKSCEQTYRHMYRMAMLLQTMWMSWNVIRSQSMYTEGTRHMMRNLQPVAHDVAGAFQRFVDLMCYTMREPSINLEGDITKSVLDLIETADVLQCRKSQIMLMLINQSVQSYVEVDDSRSVSCGTNGKTSDSSTHRQPHIRDSEKREQKSRHEAATVSTSGGDPLKPHSPLRSPGLRYSYSLGCDISQCSTHPFSTMAHTPGIPRVATFDGIFNRFTPLTPVTARASQGCSFQALAPGRSVSVMPHLRRASTQDVLEHRNHSTTPVRLPETFQFPMTSEDAEGLHAFTLSMEMFANETKLLMVSIGVMLDNVRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S122</accession>
    <name>A0A088S122_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_323460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702030.1">
        <property type="nucleotide sequence ID" value="XM_010703728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S122"/>
    <dbReference type="GeneID" id="22578087"/>
    <dbReference type="KEGG" id="lpan:LPMP_323460"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320041100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_323460"/>
    <dbReference type="eggNOG" id="ENOG502SIG6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266456at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="697"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="711"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="816" mass="86503" checksum="15D1862853F988D7" modified="2014-11-26" version="1">MTDRTEIASSTSEDEYTFLAFSLENTSETVERVEKQMVGKTDAIITHITSAEDSRSSTTPESESFVFTTMAVTPISLAVAMLCGSSVQKVLEACMDPVFLTASTDMNADNIAADVLSLMDSAMTVHVPALADLSCLEPFFAGYTRCERIDAVLSAARASSKLILRDDLPVPSSSTCMLSVDAFEGTRLRVGFRSHTADETYSVEMLKHRLHTSECEASLHSLFHYRLGATTSQQNTRNVELSSNALCGQSAALASPVAAHQAHVELEASPLLKDVCESRSDDTCVSRRALPVACAFPVAVGEEPAGIAICESRSMQLGPCPIDKEPLHAGSRGCAADHHRNLYTSMPRMCAPIPKPLLTIDAILTDTDFKFHEETASSGVREATSMSTTRSGSPGPTTSSSVTATTTATEKLCISMSAAPSFHKSVLNATIGATSVGDFCFPANAVRFRSLLTLCEDSAACPIDASEAMTEEKLMGSAMPRLYAPVDVCAGTSCESMDGVAEPWRKGSATPLHTGIGRLPSTFLHKKGLMPAGSPPKAIGVWVPQAPCPVGTSLKPDGAPPVAGLPPTPLLMVPIPTDNVSCSSADDCGSAHELQATYQTSHCLLSGSHYRRHDPYSMTGFLACAQNSNASSLSQVNMPNSCVSTLSAQLRHSTDAYPSSATREVKFCFQDPLIKASAWLLERRHFWQRDATYTPSSEWEGALHSNTHDDSLDENSDAEEASCRSLPMHNAVVAATLAEPRSASANLSLRPIDADLASPAGATAAAIAPKSYAEAARRGIVVASSAVVTAVDTAETQLTLSVQESCASRLSAAKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S151</accession>
    <name>A0A088S151_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_343200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the THADA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702746.1">
        <property type="nucleotide sequence ID" value="XM_010704444.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22578825"/>
    <dbReference type="KEGG" id="lpan:LPMP_343200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340038400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_343200"/>
    <dbReference type="eggNOG" id="KOG1810">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="73997at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056842">
        <property type="entry name" value="THADA-like_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019442">
        <property type="entry name" value="THADA/TRM732_DUF2428"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051954">
        <property type="entry name" value="tRNA_methyltransferase_THADA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387:SF0">
        <property type="entry name" value="DUF2428 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387">
        <property type="entry name" value="THADA/DEATH RECEPTOR INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10350">
        <property type="entry name" value="DUF2428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25151">
        <property type="entry name" value="TPR_Trm732_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUF2428" evidence="4">
        <location>
            <begin position="1295"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA (32-2'-O)-methyltransferase regulator THADA-like C-terminal TPR repeats region" evidence="5">
        <location>
            <begin position="1563"/>
            <end position="1709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="598"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="988"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="602"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO01946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2302" mass="245698" checksum="B3F538265DB5A085" modified="2014-11-26" version="1">MAEQAANATLMRRRQRRPDLHNTFDLPKDVQLSLSQVVRALLATAPFSSLATKVVRATDAALQELLQLILTPEQQLHAISKITGAIREIPKSQLAATLTESTGELYSWGRTLALEVVVPLLLDCRVRYLHRVLMTLLRTLLRSPDAATEAIVREMYIDRLLQCVKSSAPEAATVMKPVGGFGVHSDTCEAAAAVYFPCNSEDRDTVITSARSVGDYNAELERVLDFLNTVDGLTSTLMPMMPGIFKDTFLQALPLLADSLQWVVANATRHSRLPVSTSRDACYGTGVPLRLANEDAEAIYGVATDVLPVTHSVDVGGVFSEDLEHVRFCVRVVAAYIHKYMGSLTLSITSDATGDTVRHELTRLLQPTIVMLYSSIFPKDVLNAVGLLVASLLTVRTCDAWLLAFVCAALRDKIARCAGGADASFNSVPNLQQSKMPTALSLAHLFAQADVALRVVSSANPREVAQADGGAGVTALHDVFSHFTPNGCFALLKGILAHTSAPIRGDWASLGLLLTPLPWTLPSVTAGAKEPNSIASGTVVAYDIILQAAQQYCNLVQEPETRFMAIQTVDSVVRHVSSVLTSAVKALAQPVENGSAAALQKPTLSQPSSASATPGVDQATALRRHLASLCSSSPKLQDALSYATQLIMALWDDGTQQMSGALYGTYGEVLTIHALLRSSASHVPDKRLDLCVDTSIALDQILHAQAERRGKYHALLGSLSMMSLGDFVTVLQQHYGFPTSAADAISTFSRTLLAGASNHKIGNVAGDVFAHLAQGIAKAPPSSAIVGCSCNSETAAHVMRCGIIEPLARAITEKGYVSVSSNVSEAVNISHITAHFLAPLVKQDPTCLHTILTAVTACLDSASDGKSSSSCTVGAPEHGRVEQGVIEAVARARGVGVDITPYLAPGSTVLQVLQEGCRSLNYDVRNTALSLCVLGVKKIQAVQPWQLRKVEEYLIFNMHLGGDGNARKGLLEMMRKWVRRLMESYTSKPQHRASAATSAGSKRAQQKSEWQEDTLASAQHSRTRPAVAASVSGPDLQLELGTTEYRIAVMDHCRRLSSIFAQNIGMNAHAGAGLSAERRVTAMMGYCILLQGLRTHIARHEPVEWAVAPEPVRGGAALPLLHACVVPSLLATLSDGWSQARESARELLRAFCELAPASVFTATNGADGGSAVSASAMAARAYQDLHRAQTFRNAEGAVGRFLIFSTLTAEAQGAMKQHPLEELERLSKLVGQERMLVESKCAEMSAMRGTKAYAYIQANPLHGPLSLCAELVNLMASIERQAAAASPLPLLTLTCTDLVQCCCLVLRTCSSLVGTETVAAGATASLGADEVVDCRGHVYDRSRPQAESVMRGVVNNTWLSMRVAASSITRVLRLRPVHAMPFAAVHATAYELVHALLLTKHNGVMRSVREALKALAATLVRSRQALFYQLPAELLDYLMGPEGVTSGDVTRMLRRSQGLPHAILAVLEAEDTTVPYCLFPSAMRQLLCVARGDIAGAPTLGSAEAALLSASAETVWRSQRSNALNVMKFIFDNKVFADRIAAYIEEAFSLATEGFHNSSWYTRNSSLMLFSAVIHRFVGEHPSTGGSGVNTSLHDVAKRMPRGIAYAYAELIRGNRLVQEAKGKDGGGAAAAEVSVALFPVLQLLSMLSPDPPHLITKISHGESDDAARMAEAVMQCANSPSLMVRSASAVALCCLVPLSSLEKTIDQTRRGLSLEPLTPHHALPDSANHRGPLERHGGAAGGGLNSCHGAVLQLLQFHSQYVGTLRRHYRQKRSSYATLMVAETVSRAVSEVLLSCQRVLIKACGVSATIAASLFSLLADIVFYGPRHMLSPDRQHALRSMCVETISAYLTASHAILERGSVMEGASAILVFLAAQRDTSPIGHWTGMEQGRLTELLQREAATLSIRRGEHNLISWVMTQLQHYSDATDVLTKADVAVVLHVLAHDLHCDVSQLALQSLTELFGGATSTSSSTTMTIGCTAWGQLASHMRFAALTMSLSSEAAGVAAAPLHSFDCSILRAGQQTPASRTALSNANTSAVIASPAVTQLHAALVSLLTLPADADDSVMATPRHNSDACSAALDFITTYDMLASGANAVSPAVAHLLSYYCEPEHPLESRLAVVKALRTAESFLDCSVAAAASAPSTCPVSAVTLFLILLRLLVDDTTNIREAAATICSRSMWGPHKAPRDQVSCLLAVVRLLRRLHDAGVLSDADAIRSVMFLTDSPTTASVVTAAAPAEVTSDGEDVAGSDDEDVLFQKEAANMFAEKTVLSHLAAHILGGATSGAAIMPVCFSVYDSFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1E4</accession>
    <name>A0A088S1E4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">2,4-dienoyl-coa reductase fadh1, putative</fullName>
            <ecNumber evidence="13">1.3.1.34</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_330870</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.34" evidence="13"/>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702180.1">
        <property type="nucleotide sequence ID" value="XM_010703878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1E4"/>
    <dbReference type="GeneID" id="22578240"/>
    <dbReference type="KEGG" id="lpan:LPMP_330870"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330013300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_330870"/>
    <dbReference type="eggNOG" id="KOG0134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008670">
        <property type="term" value="F:2,4-dienoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02930">
        <property type="entry name" value="DCR_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051793">
        <property type="entry name" value="NADH:flavin_oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42917">
        <property type="entry name" value="2,4-DIENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42917:SF2">
        <property type="entry name" value="2,4-DIENOYL-COA REDUCTASE [(2E)-ENOYL-COA-PRODUCING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="11">
        <location>
            <begin position="7"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="12">
        <location>
            <begin position="394"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="582"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="585"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIO01380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="731" mass="79171" checksum="D15697DE42CE7C27" modified="2014-11-26" version="1">MKPYPKILEPLDLGFTKLRNRVVMASMHTGLESPIHATRSTTVTEKNPYARLARFYKERAKGKVGLIVTGGFSPSAEGLLYPGEKLLGPNDVDQLRCISDAVHNEGGHILLQMLHPGRYANGDQCVAPSPILSHISQTKKVPVEMSVPLIKRTVEDFARLAVCAQKAGFDGVEIMGSEGYLLNQFVAPQTNHRTDDYGGSFENRIRFPLEVLRAVRDATGSSFIIVFRVSLLDLVPNGSTQAEVFELAEKVSKSGANIINSGIGWHEARVPTIVTSVPRAGYTWATAAVRSHLRRQGIETPLIAVNRMNHPDILEQVLEDGDADLVAMARPFLSDPYFVEKTMSGAADRINICIACNQACLDNVFTGKTACCMLNPLAAHEEERAALPVTAAKQVAVIGGGPAGASAAITLADRGHHVTLYEASAVLGGQFNLAKLIPGKEEFQSSIDYWTNTLKKHKNVTLKLNTRATVEDVADGGYDEVVVATGCAPHAKSNSVIPGIEKHPNVFSYVEALLHPEKVGRRVAVVGAGGIGFDMAEFLTSPQSTSAETVAAAQYTKFTKQENCEFRKKWGIKSPAIVQEEENAGTATGSSSNNSRFSHPPGGLVKPVIPQPYREVTMFQRTRGKIGAHLGPTTGWIHRLEIRMSRVKAVDGVTYKSFDGANFVYLDEKGKEQTLVVDCVVLCTGQSSNKEFEKAATPILSKLHTIGGCNFTKKLDAKLAILQAHGLAIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1I9</accession>
    <name>A0A088S1I9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_331330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702225.1">
        <property type="nucleotide sequence ID" value="XM_010703923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1I9"/>
    <dbReference type="GeneID" id="22578286"/>
    <dbReference type="KEGG" id="lpan:LPMP_331330"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330018400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_331330"/>
    <dbReference type="eggNOG" id="ENOG502SH44">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264691at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="634"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="517"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="668"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="689"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="763" mass="81835" checksum="31876917BB92D8F7" modified="2014-11-26" version="1">MDIAPSSSCALRKRLWGLFNIYSTVMPSSNGVCELAEARRLEVPRYRSCLDALARLSSFRNLFLGSEDDMAIRAASTQLQSRLIQEMLWEEAVRLDVDCARQQRRLGPLEVQRSTAPWLSNDLDADRDVFGRALYSSAACSHGGDSTPNEDAGAADDVKGSISWNALYSVVVLYLYDQHCFHRSFLAPQVDALRSGHNEAKTMHTGGLDGAYVKVKQIHVAAMAPLVRRKTTYASRATPAGATQAAEQRPCDGATTSTFSLWYVNPSFSSQGTQSQQPTLKNAVGQHVEEEHAGRSLKPVCTPPRPPRQNPPQASPVAPSLRSPVPTQHLTHIVDASARAGSSSRYMVGCTEDSAKPVPPPRCKHTQREAAELSCKERHIGVGTDVEVINGPQPVFYPAVSVSMSSSSNPAPPGAIAIVLKRTAVEDRRQWLASPSPRPLEGAAEVFGDEPGAIEAAPAVVRIRKLRPQSPSQQNAMVTHQTHKHRTRHSDAAALKPATENTKAPAQRLYATRRPQAANPANLANATPKLTTQKSGADTGATAQKMCSCVSCPLDSRSGLAEAWPGRSEYSCDLTPPSTIPCEVCLCEVRGGSSSLDIGLERERTGEQSGSSGDAEGRHTTAFAVGALRGASVEASNGRDLMRPDWVRGTSPAKPSPSPDTPPALFMAPVAPSCASSASTRDVEDAANDQENQLPPTQTSRRRGPLHHIAQTFPLTTGEPFAPHSLNQRHQTGTVASPGMVIPVWHATAPSPTPSPHEDETEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1Q6</accession>
    <name>A0A088S1Q6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LPMP_332090</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702300.1">
        <property type="nucleotide sequence ID" value="XM_010703998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1Q6"/>
    <dbReference type="GeneID" id="22578362"/>
    <dbReference type="KEGG" id="lpan:LPMP_332090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330028000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_332090"/>
    <dbReference type="eggNOG" id="KOG0589">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08215">
        <property type="entry name" value="STKc_Nek"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000097">
        <property type="entry name" value="Probable serine/threonine-protein kinase nek1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000535">
        <property type="entry name" value="Serine/threonine-protein kinase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="36"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="12">
        <location>
            <begin position="351"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIO01500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="448" mass="50409" checksum="8B14E99DC84018B9" modified="2014-11-26" version="1">MAEAIPISTQQVPDKSEVELDFKDILGPMGSNTCKYERVRDLGSGSFGKALLVRRVSDGQLLVAKRMDLTTMSEKDKKYATAEIQCLASCDHFAIIKYHEDYVVEPHIVIIMEFADAGDLNMQIKQRAKDGFIYFEEHEVGYTIVQLAMAVDHIHRRRILHRDIKGANVMLMTNGVIKLGDFGFSHQYESTVSDQVAQTFCGTPYYLAPELWGHQRYSKKADVWAMGVLLFEMMALRRPFVGQGMRALSEAVMCSKRDCELPQHYSRSLKELCNIMLRADPNLRPSCAQLFKLPYMMKLLMDFGTSVDNSQLVSDSLKTKIHTNICEIRQASAHDPEAFGFVGHVGTVCSSVFYEGYVRKESGEAWKERFLVLRDGGLVISRHKGDKETKPLPVAFIDSAVFVPEKSACAPGVFAIHLRDAKTMWLQALPPETAGIWVHKIQQSIGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1T8</accession>
    <name>A0A088S1T8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_050150</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="AIN95456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703778.1">
        <property type="nucleotide sequence ID" value="XM_010705476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1T8"/>
    <dbReference type="GeneID" id="22572093"/>
    <dbReference type="KEGG" id="lpan:LPMP_050150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_050006500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_050150"/>
    <dbReference type="eggNOG" id="KOG4308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="333024at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001522">
        <property type="entry name" value="Leucine_rich_repeat/Leucine_Rich_repeat/Leucine_R ich_Repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN95456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="442" mass="47328" checksum="8B3522668E998B1D" modified="2014-11-26" version="1">MPASARRKKDKVPAPGTKGEKSTGFYTKKRWRSVLQETRVDLAGRALGPRGALIVGTALFRNTYVTFLDLSHNELGDDGAISIASMLRGNTHVQYLNLSHNNMTDAGGIALASAFIPNVSPSGQPGQWNRTLFTLVLMGNRLGDDTLLAMGNAAACHRDLTRVDLSWNTVGENGTKCLMRAYERNPLCVYELAANAIGDEGAVYLCEALQRHGGKTQTTLNLYRNSISCPGAEAVGRLVASSSIMQDVSLACNTIGFKGVQALQHQLTDAAVIASCTLRTLNLSDNWIGDEGAASVAAVIKADLPSLERLDVSENKITDVGATAIITAALQNTHLLLLNCEANRLGPKAVDAVVRLIHETRTLKSLNVAGCVGSADHRRTLTIAVGETDGLHVELGPSPEDATGSKDIMFIDKMTEHLQMLADQEAQRQKESLAAKKTKKAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1Y8</accession>
    <name>A0A088S1Y8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_352810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703218.1">
        <property type="nucleotide sequence ID" value="XM_010704916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1Y8"/>
    <dbReference type="GeneID" id="22579310"/>
    <dbReference type="KEGG" id="lpan:LPMP_352810"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350035400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_352810"/>
    <dbReference type="eggNOG" id="ENOG502S1IS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264358at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="999"/>
            <end position="1020"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1020" mass="109571" checksum="7A2C262B435E89E5" modified="2014-11-26" version="1">MAASGISASWTDLLAHTPASPGSSSRVALGEVAALCLALEAPKCYAVYRPSNPGGCVNRHISTGPALATPQHFLQLLARLRETLGTPSEAARIAEVLVDLLNKPPHPHQPGPWDLTENEVRAVKATAIQHVMDTVQGGSDALAWLARLLRLTGTRAGEGGVTESEVRLLLAALSERYGLHGGSPAPRVHCGDADSEWLLTCSPGVLAAIAAAMLRSTTEGMKAHALELLETAALKRLSWTSLSSDKAVAGYSYCNDVQSGTSKPSFDETVVVHCAEAAAVQGDAETVTRLIFLLYRARGALGFATLAEHRQQRRSGRGNEGTRGRTSGDLLPCTSAWLSARWWCRGDGAMAEQTPTLLEGDATDMHFELAVVRLLKSAMHALLYNPQRMSDPIVCTVEEALSLWDGLKSATSWPGIAAIGAELLRYLADQHIRLAVVAGEGDKGAASDDLHVRQAALRVYGHLCRAAPLRQRKTAEHVELNYFTLLMLRIFSTRLAIIGDASMLVPVIASTTAAEQILRLFANLSGPPAQEVALPYALAASLVILAAAATQKDYTVSPSLLAPLTAYFSDTKSLHYYCVAARSAEVPAHIAVSGGLVLLHLFLWSSVPEDEWARSDGELWRLFQRIQKVKETGQGADAATAAPATAAAHHVAAWLKVAGDQQRSLLWLLLLSAKQRDMSWCRAVVDVFCSPASSTLISSTVNFVYDQLPQAELNSVVALLYACGNNDNPTHASQTLDRVVSASLQLPICALTLEALEAQLQRFSGGRQATSVLVLGAASIRALAERCAATPKEDADDEVAVEGFLRVLQPLLVGPTAAPPLCYTVVVLTQASLVELQRMHTDANDAPRHASAFVCALHDALVSRATPRAYQVRAASSWPLLPSLAATLQEQKELQSVDGLREATAAARHLEHTLPKESRPVVCLWVEREALFDSPHALSAKAEVLRHYGVREVSTHRAHVEKAKRDIFSLVRSDAAGTVHPTAAQMTGENDLAKAKAARRTRHNSLLSAVSERSRRQRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S220</accession>
    <name>A0A088S220_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pre-mRNA branch site protein p14, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_353110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703248.1">
        <property type="nucleotide sequence ID" value="XM_010704946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S220"/>
    <dbReference type="GeneID" id="22579340"/>
    <dbReference type="KEGG" id="lpan:LPMP_353110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350038700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_353110"/>
    <dbReference type="eggNOG" id="KOG0114">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275748at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001023">
        <property type="entry name" value="Pre-mRNA branch site protein p14, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13893">
        <property type="entry name" value="RRM_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="47"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO02448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="160" mass="17883" checksum="325765BDA45F8B65" modified="2014-11-26" version="1">MLVLGYYYSARPTTFTLPVSLSPSSVMCTHVSPNNANVHAAAMPDERILLVTGIPSKQCTSEYLYSLFGAYGGIQQIRIGSSFITKGCAIVVYEQCEAANNAVGALNEYALSKDRILRVSVYEEERDKKALERRKRKREMQAEYKRHITNVAQAADEPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2A1</accession>
    <name>A0A088S2A1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_340170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIM50 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702445.1">
        <property type="nucleotide sequence ID" value="XM_010704143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2A1"/>
    <dbReference type="GeneID" id="22578521"/>
    <dbReference type="KEGG" id="lpan:LPMP_340170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340006900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_340170"/>
    <dbReference type="eggNOG" id="KOG1605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000171">
        <property type="entry name" value="Nuclear lim interactor-interacting factor,putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FCP1 homology" evidence="3">
        <location>
            <begin position="46"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO01645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="240" mass="27242" checksum="BD220652A39B3E14" modified="2014-11-26" version="1">MNKQRIRGESFKQEYQAAGRHRTNRKRDPSMNKTDPHLVIAPQAEIYQGKLVLVLDLDETLVFARSGPLYARPGIPEFFQMCKDKGIEVVVWTAGLKAYAQAIVSNIDTCNAVSHCIYRHNKWFNGQPGYRKDLNALGRPLDRVLIVENTPDCIRGYQDNGILVSDYEGGDGEDNTLYALAELVKVLSESDFTVPQFIANCELLRREPVMTDVGDYINAYTLDTNCFDPEHVRVNRDLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2A6</accession>
    <name>A0A088S2A6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Telomerase reverse transcriptase</fullName>
            <ecNumber evidence="2 13">2.7.7.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Telomerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">TERT</name>
        <name evidence="16" type="ORF">LPMP_354030</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Chromosome</location>
            <location evidence="13">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the reverse transcriptase family. Telomerase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="2 13"/>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703338.1">
        <property type="nucleotide sequence ID" value="XM_010705036.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22579431"/>
    <dbReference type="KEGG" id="lpan:LPMP_354030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350048300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_354030"/>
    <dbReference type="eggNOG" id="KOG1005">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="289721at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000333">
        <property type="term" value="C:telomerase catalytic core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003720">
        <property type="term" value="F:telomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01648">
        <property type="entry name" value="TERT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021891">
        <property type="entry name" value="Telomerase_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003545">
        <property type="entry name" value="Telomerase_RT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066:SF0">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12009">
        <property type="entry name" value="Telomerase_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01365">
        <property type="entry name" value="TELOMERASERT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00975">
        <property type="entry name" value="Telomerase_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 13 16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="9 13" id="KW-0779">Telomere</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="15">
        <location>
            <begin position="777"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AIO02538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1452" mass="157519" checksum="48A0DE9DEA49CCD9" modified="2014-11-26" version="1">MSSSFPSILGFVGPLSLKSFLEQYFGLRLTFSVEAASPPRATTEAETPSAARFRALHDVVLPPNQSFLVVVYVALHASSPPPPITAPGCTTPATLASGCGASATGLGWLRQPLAHQPVVATAHDTCVKRGSLTDRPNPSSVSSLSTGKSGSARGPWRASVPWLLYTNTSHRPFTDVLLRHPWWASFAACLGPAAMGFIEMYCPIVLQLEAMAGGVQVLGPALKHAALETSFSVAAQSSEMKGLPPHRGANVSSRGVKRAAHAGVCTAPLPLPKQRRVETVEELLKAKAGGGLQRGVALSSHPCKDGPSATPVRSAAIPATWAAALLRTDVPRIRLYSVRISDSDYVDDGDGALPLPAGFLEAQWLRRHPHSLHSVLQTALPKRTAYGASTRRCSVCTSERGAGYTSVEDIPMRHVAHVFRWLVLQPSQGSADASPTTPLRFDLPSYLRRVLSTVLDQCSRLDLRGAALKHAGYVEEAFHRQQQGVEPWDVQRLSTPVCVVVSYLRTLLSTLRWAPLKGAKEGSFWGITAAGSEHVLDALMRAVQGWLIAGRHAVVPVSRFLDGVPVAQVPWLNGFYTSPSTSSSAATSSAARHARHERSRVQQRVWLQFILFLTQDILPFLVRASFTVTWSSKNTHTLLFFSVAVWRRLVRHEVRRTQSFGATRPQMALTLGSVRHASVERAALPSASSTCGGVATTALASLHSVASTASAVNSAPKDVWCAVRTAGAMTHRGAHANLSTHSGGASCLYAGVRFRPDGRKLRPIAVVRSAPLRSLKEMARGSPSPYSYSHSIARLLCRLGCSDTDGQLPAATATLLRRVQARSRRNHRTGFRRFRHPLPTHLPHRAALQNALRCLVSGVEEQRVRDGLPRLSNLSHQDEYAELRSFCEEVRGGHALSCEGLAGTASAASPNPPQGAAACFTPCAMQTVTLVRSDASRCYDNLPQERVLAAVASLVKHDAYRVLHFTVIHALNGEAAHAGGCLLRRAFTTRTIPYTEMECGVLARIPRGHIYWEEEEGRTQGGPHATAAASCAGDPRSRCGPNFISGAAVRALLSEHVRHHLVVVSGGSLFEQRVGIVQGSPVAMLLCDYLFADVVDTALSCILSEHAERSLLLRRVDDVLVATASPAAAERCLQAMQRGWPSVGYLSNPSKLTLSNACGSFVPWCGLLLHDTTLEVSVEWRRIGALLTSLRVGDPRYVHRGDREPLYFTQRFLAVLQLRVVPTALCGRLNSKTRQLQTFYEVGLLWSRVVLEKVQETLPVARNRDVAVLLLRPLAVCVGRLWRLLHRHQRFLAARQSSCGVSAAEVRACVLTALHRTVQAKLRVLQARTIRVMCAQRGLPQRGASSLNRCPKSLCAHKAPSAGHQGCKRRRKGCRRRLNPRTRLRSFWWMAAAEVELQWRRALGALHRAASRALPGHESTAPSSATSASLLMEDGLGSMHARALSATRLSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2Q5</accession>
    <name>A0A088S2Q5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha-ketoglutarate-dependent dioxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_355070</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alkB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703438.1">
        <property type="nucleotide sequence ID" value="XM_010705136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2Q5"/>
    <dbReference type="GeneID" id="22579535"/>
    <dbReference type="KEGG" id="lpan:LPMP_355070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350059200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_355070"/>
    <dbReference type="eggNOG" id="KOG3200">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="412814at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032862">
        <property type="entry name" value="ALKBH6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46030">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46030:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="202"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="605"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="620"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO02638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="712" mass="78560" checksum="15BFFBD909A79140" modified="2014-11-26" version="1">MRSFRAVQRLNNCVPSLCTRDAFQRPPLQRRLIIAKAPASHSTISNATAGIGMEMQAKGFHHSTPNFNTAEFSEMGDLADLANDIVTENAVGIDFVRDIYGPWLVMTEDLQGELFVDHDRFVYYRPANGLGYGIGKLQVLDAGATGTAFTCQLETYSYQPMDTVVPQYGLTFDITGMVKRVTAKSSDYTTFSLGGVWRRNNRNSDAPALLPSQRRGSGTAVADASASPTSENLSNENARGESCEKMSGQFNAAKLSPWNPSAAAKPFEPNAELQNVFAQVFPERLRVESHVRRAEARRQSQAARHLAGSAGEPPSLHLDLAPYAVGNIPGIYYIPDYISVAEEAQILAFIQRTPQELKSKLTKRTCQEWGCTMCESCQKSFVSDANMPPWVQDFTDMQVYDGLFTPTTFPNSVRVHEYQQGEGIGPHCDGPIYVPMVTVLSLASSCLMSFYPKRPLYENHPMDHYNDTFKFAEGDIGRRVPLQSVVMEPRSLLIFSGEGYYHYPHGVSDKAEDVLAPGVVGEVVNRRFLGDPNVQSIPRTYRASITTRNLMTRCGHQPARAEYAMKRAWYLYNRLPIPSELFTPLPLSPQSAGVSIGTSSGAREARELSATLSTEKRVESSSSAPLPSGSSAVDTGLRKAIYELRTGQEQLRNSIEELKQLVALSIPAQTTFQTEAATILNHLSSSVLQLESKVDDLFEEVGRGKRKSLTDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2Q7</accession>
    <name>A0A088S2Q7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_354040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703339.1">
        <property type="nucleotide sequence ID" value="XM_010705037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2Q7"/>
    <dbReference type="GeneID" id="22579432"/>
    <dbReference type="KEGG" id="lpan:LPMP_354040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350048400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_354040"/>
    <dbReference type="eggNOG" id="ENOG502SM96">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265877at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839223" description="EF-hand domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO02539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="871" mass="92390" checksum="A964C1C297782070" modified="2014-11-26" version="1">MSGVAGYPTLLELCILVNAAAPAPSRHASHFDAPLTQYLTSLPADTSAIMTWANSANSTSRDPIAAAVDVAAYFPYQCSPASRASQGSSLAPSGEVEQNPGADSFDSQAKEGVTMSSAPLNLMSRRATLPFTADVTSNGGGGATTSEGAFRLLLPTLVGNSEITYAENPTCRETHSRVTCAPEVVPGDAHPQSCLYELASPRGANAGEDAPENIPAAAYIQSDLSLTAQDTFTVKHNGDDRGERSAPSPSVPGEGVGSCIKHETRSTFPQSIDLVQPNALLVTDAVSEMYTNSLVPMITSKSAQQPSSLTQLLGSCEGRSVAASVSVPCALHQRDYCGTSLTAFMPGSPLHLIGEPSELKREHLHLSFSPDATLEFDEHGPSPASGGTPTAELTDLSSPLSPLSLSFPESLSSAPCARAQRRGTVAAPADVNMFPEGKAVLKSPETLKEEEAITLIAALPSCFLWKGLYGPAEDCRDLFDIVPMAPATSSSQAARACSESPGDDAASVGSAGAFFVSLFPPTLSKWMRWVSRKYHVVMRHTAGAAGVVQLSQEQRSKSPPKRSCASPRNSSDGASGDGAYPPPGDSTEAVDNDSAAFCDVGSLKDEMAYLPHTLSFSALQANFSYGDEWSRHSGAQEAQDDLTSPWNGARHNSWFRVGLQTEQRGAVRAAGGLMQLRRSITASSPSSLISDASFLTSSGERRWGSPTNLSFSAESLTTTFGALTAAHTFRDGTLQRLSHSLGGTLSSSASCTSLSGDYHRPSLPSSLGSHSHRSGSTTSAIADDNYRDMLYLLFHHPPSSLIGDLTQCYEAYKAMVDTSSNGHHVLNWSELVLLLQPEDYIDYRALFPPNHFVTFEDFVEFVEVLSVRYHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2R7</accession>
    <name>A0A088S2R7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="14">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LPMP_070700</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="14"/>
    <dbReference type="EMBL" id="CP009376">
        <property type="protein sequence ID" value="AIN95756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704078.1">
        <property type="nucleotide sequence ID" value="XM_010705776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2R7"/>
    <dbReference type="GeneID" id="22572405"/>
    <dbReference type="KEGG" id="lpan:LPMP_070700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_070012000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_070012300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_070700"/>
    <dbReference type="eggNOG" id="KOG0204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000104">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000128">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF486">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 14" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="372"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="827"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="897"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="930"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="971"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1003"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="15">
        <location>
            <begin position="87"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AIN95756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1117" mass="123369" checksum="1C571E573DCBACDB" modified="2014-11-26" version="1">MSEMGDHDTLLPLHSATSVSRSYGTYDYDVHEFDRLRKEDIAYSVRQRFSKRSNTLITGGEHFGTGIQESLEDIFARANEAMPLYEKLGRVEGISNTLHTSLTGGVDAATVAARRAFFGRNALPEDPPLTFWAIYKASWEDSMIRLLTVAAIVSLILGLTVPDPGQTEVNYKTGWIEGFAIVCSVVIVTTVSSVNDYRKEQKFHKLTEENSAQPVRVRRGGEETTIDVTEIVVGDVVGLSPGLVVPVDGLYVTGMSVVIDESSVTGENDPKKKSVDAPFILTGTVVNTAESAYMLACAVGERSFGGKLLMESCGAGAPRPTPLQERLNELADLIGRIGLGSAMLLFALLSMMEVLRMLQHEPGTSYLHFLDYFLLCVTIIVVAVPEGLPLAVTIALAYSQSKMHDDNNQVRRLRACETMGNATQICSDKTGTLTQNLMSVVQGYVGMQHFIVKRPGDLLEPVPLSDMRAASLRRLSEGIAVNSSSEKVVSTTDKEGHRVAPYWQWVADRGNKTDNALLDFVDRVAMTEADACDMKSRPHQRTRKACQQRGFTIFPFTSDRKRMSAVVRQEDGTLLHHVKGGSDRILPLCDRYVNETGDEVPMTDEACERIAQQVKKLADMGNRTIGVAYAVLSGTELPEDEPTEALVWLSLLGIQDPLRPEVADAVMKCQAAGVTVRMCTGDNIDTAVAISRQCGIFNPYYGDLAMTGQDFRNLVYDAYGDEERMAKFWPVLDHMTVMARSQPLDKQLLVLMLMTRGEVVAVTGDGTNDAPALRLANVGFVMRSGTDIAVKSADIVLLDDNFRSVQRAVVWGRCVNDNIRKFLQLQLTVNYVSVALTFIGSLMAGGRSSPLTTVQLLWVNLIMDTLAALALATEEPSEECLKRQPIHRKAPLVSRRMHMTIFMAAAYMLGLTLSMQAYGNVLFKAGPLGGIEHSTIVFNVFVLCTLFHMFNCRKLYEEFNVLEGLLSRSPLFIGVITFCFAFQVVAVQVFGDFMKVTSLRSEEWLGCVIVAIGVLVVGFISRLIPVCEPSFEKTFDGSMLDEDAKAVLARVDSAVTKAQATTEEYKEGIYLDKARRLRARALWNEARHHHLHVSRIVNAFRRTRVDRLEEGRHLGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3N8</accession>
    <name>A0A088S3N8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Fructose-6-phosphate2-kinase/fructose-2,6-bisph os phatase-likeprotein</fullName>
            <ecNumber evidence="1">2.7.1.105</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_350150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.105" evidence="1"/>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702955.1">
        <property type="nucleotide sequence ID" value="XM_010704653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3N8"/>
    <dbReference type="GeneID" id="22579044"/>
    <dbReference type="KEGG" id="lpan:LPMP_350150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350006400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_350150"/>
    <dbReference type="eggNOG" id="KOG0234">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000073">
        <property type="entry name" value="Fructose-6-phosphate2-kinase/fructose-2,6-bisph os phatase-likeprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF36">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO02155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="485" mass="55341" checksum="EC6D7C12D156927D" modified="2014-11-26" version="1">MVLVQLRASNICDVDDAKETNTIDFRHMVGVEYHTPREVVRPPPSLTGTEAHHMAMTSTGLYRFSNATSPVVIFVSSEERCSLSARFFCTRFVHYFRWIGESVQLFVASKNFQDHRPAPYARQRDIWLQENHRCVSAALSYFDSDPKLGFAATPVAVIFTDCDCADARRSLVSALPADRSFLIRYVRFSEEWESHRCNSYRFIDVSLQRQALRASRSSGSIVCSSLTRFLNSMLPTLYQLYSEEPQEGAPGDTLKSFPPIFFTRHGQSEYNIEDRLGGDPDLTETGCVDAEDIARFFELQVKTNVNLFEFRTTVWGEDDDFEVWCSQLRRTQRTAQPTADILSHGVLKPFKSLNEIHAGICEDMTNEEVKLLYPFIQLFRHTDKVGFRYPDGESYVDLVRRLTPLLNDLNNCRKCVVVVAHQAVLRTMLSFFGGRPVEEAVHAPCPQRTIWVCTMNRLGEPRLAEIALSPRQSQDEGPGVSWEGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S426</accession>
    <name>A0A088S426_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SAM-dependent methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_101170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696839.1">
        <property type="nucleotide sequence ID" value="XM_010698537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S426"/>
    <dbReference type="GeneID" id="22572854"/>
    <dbReference type="KEGG" id="lpan:LPMP_101170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_101170"/>
    <dbReference type="eggNOG" id="ENOG502SBDD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10017101at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN96186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="238" mass="27673" checksum="1C268913FDCE9378" modified="2014-11-26" version="1">MHTYACRLCASPSVMLFHTDRMREYHQCSQCHLVFVPDRFVLSNADEKALYDLHENVPGDAGYEKFLSRAAKPLADYFPPNARSEAMQGQRRGLDFGCGRVQVLAHMLSTAPYNFSMDAYDLYYFPENRHFLEREGHYDFITATEVFEHLQDPFSVLRTLWRCIRIGGVLVIMTKRVHGTIDSFCNWHYIRDPTHITFFHQDSFQWLADFLPSEGEACEARFVSADVVLLIKQQSKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S524</accession>
    <name>A0A088S524_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_356210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703550.1">
        <property type="nucleotide sequence ID" value="XM_010705248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S524"/>
    <dbReference type="GeneID" id="22579649"/>
    <dbReference type="KEGG" id="lpan:LPMP_356210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350070500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_356210"/>
    <dbReference type="eggNOG" id="ENOG502QU5Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="247165at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="331" mass="38629" checksum="7DDBA7E8CCC4EF7C" modified="2014-11-26" version="1">MLHRTAVVLKSQHKNVLRKGRPHMQKYKELNRWQREAQGITKWDQGHSHRPQPYVERFNPEGVGLTRGTSAYAWKWWHTQYPWLPNVAPDDYVPPSPRGIRPAAWDDEFAEVVLSMSNEEIQSYLLDKLTEVIFAETQRDGYELRRLDFEGTPLTDRPERRIVENFVFEEETLRERVLDQVVEGVFRLVPTSDDRLALKSVANIVDFVLTHVTVARKPEKHEIPEAARSVMRSHPLQPQLGFVHALPTDNRDAVVREWERMHHLDWQFGKAVYEPRSVENERGNFTWLREVRHHEARTAFEEDVASGKARRRHMDKINAAAQAPSSNAASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S9B5</accession>
    <name>A0A088S9B5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Surface antigen-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_211370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698923.1">
        <property type="nucleotide sequence ID" value="XM_010700621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S9B5"/>
    <dbReference type="GeneID" id="22574959"/>
    <dbReference type="KEGG" id="lpan:LPMP_211370"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210018300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_211370"/>
    <dbReference type="eggNOG" id="ENOG502S1ZQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="261141at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000041">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47988">
        <property type="entry name" value="SOMATIC EMBRYOGENESIS RECEPTOR KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN98216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="454" mass="49776" checksum="C28097A7AD0CA0D4" modified="2014-11-26" version="1">MTPPLLRYRRTTRACGLVAAVVLVSALLYSGTRAVEERSMSLYTEAQQLHTRRFLDEFVQSMPGLRNIWAGDDFCAWEAVTCLRYGVSISATNWIRLAAFPGRLPEVSSVDVDMSQVVVTSITMRANGPNLSGTLPVSWGLLRNLGKVHLDRNSLTGSLPPEWSDLDGLVELYLSNNSLTGSLPGSWGKSMKSLSFLFLDRNALTGTLPPEWGRMRLIRSLILEKNRLNGTLPVEWQHMQAASTLSVGMNDLSGTLPHEWARMSVMGWMDLNSNHLTGTLPAVWASMTFLTNLQLFSNKLTGTLPAEWRRLTLLEELRVGDNRIVGTMPASWSAMTSLTELRLGRNNLLGVLPTAWGAMALMQVLDVSGNSLSGTLPVSWGSMRHLDTLSVRDNKLGGPLPVAWRTLPAIQHLHLEGNRLCGCLPINWASPGVDITVDEAVMRTNCATANACAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SB22</accession>
    <name>A0A088SB22_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_242190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699558.1">
        <property type="nucleotide sequence ID" value="XM_010701256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SB22"/>
    <dbReference type="GeneID" id="22575628"/>
    <dbReference type="KEGG" id="lpan:LPMP_242190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240029200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_242190"/>
    <dbReference type="eggNOG" id="ENOG502S2X7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19623at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="236" mass="25814" checksum="4EFCBC7DDB3911CD" modified="2014-11-26" version="1">MTVAEFRNAVVPVVVRHAQRYPNNGVVIFNELTSLEPNKVRVLLPLLGRGTNFPEYPSVSIAPLLVILTTDFGREGRTRGKSLLEMRAFITDEFTELYSKEAASHVRTFPFLPISLSTAGDIVRVVVREIGCSAPQPLCLTINDSAVLWLVEKTKMLLPAENGRAVAFETKLQVEALLEEVMANNALEGGTITTDEIYMDVAETCSYRRCTILLEGNGTLAIACQGTGTHTRVSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SC47</accession>
    <name>A0A088SC47_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_261480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699968.1">
        <property type="nucleotide sequence ID" value="XM_010701666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SC47"/>
    <dbReference type="GeneID" id="22576051"/>
    <dbReference type="KEGG" id="lpan:LPMP_261480"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260020100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_261480"/>
    <dbReference type="eggNOG" id="ENOG502SQSH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="257699at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="136" mass="15238" checksum="72208838DDD3C26C" modified="2014-11-26" version="1">MGSKPSKLNCKQSIVGPASRNPKRNSDLDALSNSNLRSRDAIDSSNPSNSMKERQSPERRGFNNPLPARQSGSHDRAQRRQTRMLGAQDVDGTHEDLDERPFRQGKVNRVPTKALLKPPKNQNSIIASPDEDYKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SCJ7</accession>
    <name>A0A088SCJ7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Calpain-like cysteine peptidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_270490</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700138.1">
        <property type="nucleotide sequence ID" value="XM_010701836.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22576225"/>
    <dbReference type="KEGG" id="lpan:LPMP_270490"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270011500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270011600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_270490"/>
    <dbReference type="eggNOG" id="KOG0045">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="258624at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.380:FF:000014">
        <property type="entry name" value="Putative calpain-like cysteine peptidase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022682">
        <property type="entry name" value="Calpain_domain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056040">
        <property type="entry name" value="DUF7623"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF379">
        <property type="entry name" value="CALPAIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01067">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24610">
        <property type="entry name" value="DUF7623"/>
        <property type="match status" value="63"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="9">
        <location>
            <begin position="28"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Calpain catalytic" evidence="9">
        <location>
            <begin position="646"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="domain" description="Calpain catalytic" evidence="9">
        <location>
            <begin position="5539"/>
            <end position="5815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="4204"/>
            <end position="4229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="6101"/>
            <end position="6164"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="2529"/>
            <end position="2556"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="3599"/>
            <end position="3626"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="4344"/>
            <end position="4381"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="5300"/>
            <end position="5327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="4206"/>
            <end position="4218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="6113"/>
            <end position="6129"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN99431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="6164" mass="701301" checksum="076FBA9BACB372BF" modified="2014-11-26" version="1">[encoded data, 6164 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SFA7</accession>
    <name>A0A088SFA7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_302740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701297.1">
        <property type="nucleotide sequence ID" value="XM_010702995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SFA7"/>
    <dbReference type="GeneID" id="22577327"/>
    <dbReference type="KEGG" id="lpan:LPMP_302740"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300032000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_302740"/>
    <dbReference type="eggNOG" id="ENOG502S062">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266874at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="274" mass="30086" checksum="D663EB0FDC23BC7D" modified="2014-11-26" version="1">MLRTHILSSPQTCSSALGVLCSGSAYTVATRPFHTTRLAFNSSSSGSTTQQRSAADEDKEELERERRLREQFAQKIQQGLPRPQGGADPAAGNMGGGFGLGPGWGTGGSGGLFAGQPPVNPDVVRRMLNFMFYLTALLFLMLMVPLANTNSPLHTMQGLPWWELPIGSAAYFLLLRALYSRREQNRIKTEFENAARANPTLTFDQFITQNHPTMFQGYRTSQPEVVAAVSACLSSAKDLRFAQTMVRAAGRAKDPRSSTDDIMDALRHDFPHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SIT3</accession>
    <name>A0A088SIT3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein kinase, putative</fullName>
            <ecNumber evidence="8">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_340970</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="8"/>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702522.1">
        <property type="nucleotide sequence ID" value="XM_010704220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SIT3"/>
    <dbReference type="GeneID" id="22578601"/>
    <dbReference type="KEGG" id="lpan:LPMP_340970"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270008900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_340970"/>
    <dbReference type="eggNOG" id="KOG0615">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="27"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="374"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="436"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO01722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="500" mass="55227" checksum="23DC3FBE61E17121" modified="2014-11-26" version="1">MTLLPPKMNVPATPALDGVDIHTLYDVSQGKVLGKGGFSEVLAVRHIPTGKIRALKVMTRASLVGKKGEMVAHEKEILRRTCHPGIITLHEAVQTSDKVYFALDLMNEDLFEFIVRNKAINEELSRAIMHQLMSGIAYLHEQSIVHRDIKPENILINVVMMNDEVKSQGTSSTSTAHNDAESPTHAEGLQVMTDVNSFPLDKLNVEVKIADFGLAKVVMEWDVRSTPCGTSFYIAPEVIRGIEEQGAKPLCTNQLLVKSVDVWSAGVVFYVLLCGRPPFHGQVRTGHDRRDLLRKIDHGVLFNPKHGWDNISEEAKNLILKMLDRDTSKRITSEEVLRHPFFTNHGYLKPTPAPDPHSRIAQMHQRSQKTKVVGVVAQSDEAHGTTPTPLSVPDGPQGAAHPSPAGSLGKVHSSSSTGSFLTSIKDFFGHRSKHMSDVSKEDRQRMRAELAELQADVIAEDDKEGEVTSYKPSMPVKEAKPTRIAVMNMKAKVGPNALRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SK85</accession>
    <name>A0A088SK85_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_350800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703017.1">
        <property type="nucleotide sequence ID" value="XM_010704715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SK85"/>
    <dbReference type="GeneID" id="22579109"/>
    <dbReference type="KEGG" id="lpan:LPMP_350800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350013600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_350800"/>
    <dbReference type="eggNOG" id="ENOG502SEAK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273785at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="305"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="346" mass="36869" checksum="0457913B97E0BD49" modified="2014-11-26" version="1">MQWKLQESRCRRGDQQPLSRSPAVTPVALAKSDPTAAANATSSDQPCSVTCNSLRNDVISLYTQVRQSLPSTLDGSESDDDMGGAQAPTPSAQPVVSAGEPSALTGIQEVFVRTPEEQERDELVARARDEFLSQVQALQSVYYDKYRRWMDVPASVLDPPPVSSKKPASTNGAVVASESTTQHGDSESEWAALLKDLGAAAPHPPRSMAQADRVNSSDVADHTERPHTVASIFRQVKLRRPLRPSAVSDDVLESMYRARAEALETPKSWSSASGLRSSAPGASASMAPSFTGASADTTVAEAAALAPLSSQPSPSVAAIRKDTAPPVSRRGRWQIVEYDEGDDAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5B0</accession>
    <name>A0AC62A5B0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">40S ribosomal protein S15A, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1120060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="XUY36969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="130" mass="14696" checksum="6A572BB6517B98D4" modified="2026-01-28" version="1">MTMMSVLANALRTIASAERRGKRQVLIRPSSKVVVKFLQVMQKHGYIGEFEIIDDHRAGKIVVNLNGRLNKCGAICPRFDCATTDYEKWMKNILPSRQFGFVVLTTSLGIMDHEEARSRNTGGKVLGFFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5J2</accession>
    <name>A0AC62A5J2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histone H3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1620660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="XUY37077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="66" mass="7238" checksum="D87F239EB5F19D1A" modified="2026-01-28" version="1">MPCARCRACRRRGGPALPEQRDPGDPGGVRCVADGCHEPGQHPREACVTVRPKDVQLAVRLRGERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5S5</accession>
    <name>A0AC62A5S5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">D-isomer specific 2-hydroxyacid dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2020550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="213" mass="24157" checksum="D81C5700B25F675A" modified="2026-01-28" version="1">MLYFNRFPWRLVASKNEKKWNRFNCIELRRQKMVIIGYGDIGQACGEKATALGMEVTGIRRSGDNKADKFGVMVRGNDALDESIREADFVVGVLPGTHDTKHFFNKEFFAKMKPSAVFINIGRGMSQCEADVAEALNKGIIRGAALDVFEVEPLPKDSLLWEVPDCKLLITPHCGNLTENVIERTMEIFMDIFEEFFTHSRISAHTVCLKRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A668</accession>
    <name>A0AC62A668_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amastin-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0820040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="XUY37284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="187" mass="21250" checksum="68964CA9A4383FB9" modified="2026-01-28" version="1">MEFTLVFLLYAVVQFIAFLFVLVATPLDMLYDKNGSRFDNRPCVTLWGTKDECYGLTYEMTSDEVWNVCPVRRNRFRAAQAFAIISIFVYGLAAVLGFILLWCCSHLRFVCLALNVTGIVTVGFVWASILVTYYKTEFPCLRENLYTVLGSGFVLLVMAWCLDIINIVLLLLPWQAAHPSESGETKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A696</accession>
    <name>A0AC62A696_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amastin-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0820250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="XUY37305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="199" mass="22009" checksum="E4FF7A32AC3FD807" modified="2026-01-28" version="1">MELTLALLLYAVLQLIAFLFVLVGTPIDMFRSRDEAPFGNTPCITLWGIKDKCYSGMLSQNSDDLWSSCPGRGSRFRVAQAFAIISIFVYGIAAALGFIMLCCCSSLRWVCLALNLTGVITLCVVWASMMRTYYALDGRCFGQRFRNNFGSGFVLLVFAWCLNIIDMVFLLLPSQAKDPSEIGEPIKSAAASESNYAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6Q4</accession>
    <name>A0AC62A6Q4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATG8/AUT7/APG8/PAZ2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0920090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="XUY37326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="124" mass="12846" checksum="4224028B6550883B" modified="2026-01-28" version="1">MSAYVSSTPLEARVARCASLRATNAVPVVVEEAQARGGKAHFSALPRETTAAQLVAAVRAFRGVAANKPVTLTVAGCSVSPSATLGELHDACKQADDGMLYVAYTAERSMGAATWKPCGSCSWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RH76</accession>
    <name>A0A088RH76_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable 26S proteasome regulatory subunit rpn-6.2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_020280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, rpn-6.2 is required for proteasome assembly.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009371">
        <property type="protein sequence ID" value="AIN95208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698173.1">
        <property type="nucleotide sequence ID" value="XM_010699871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RH76"/>
    <dbReference type="GeneID" id="22571838"/>
    <dbReference type="KEGG" id="lpan:LPMP_020280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000014800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_020280"/>
    <dbReference type="eggNOG" id="KOG1463">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1418352at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000019">
        <property type="entry name" value="Proteasome regulatory non-ATPase subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040773">
        <property type="entry name" value="Rpn6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18055">
        <property type="entry name" value="RPN6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="225"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="481"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="484"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="507"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00056935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00069091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN95208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="532" mass="59379" checksum="07EC2D1835A40388" modified="2014-11-26" version="1">MIPGGSVDCAHTLEVAEDYYGKGDRRTARELLQSIVTTDVAVDDGDSIRAKEQAVYRLAELLTVTKDGEAAIQLLSDVRPFFQVLPKAKTTKMVRKLFEHIVQCGVPLKQQEAICLETVDWARKERRTFLRHRLQLRYVEILFAENRKNDALASLSALLKEVRRLDDRTLLLDIYLLESKLYYAVMDIQKARAALVSARTTANSIYCPPLSQAEIDLQSGVLHADEKDNKTAYSYLYEAFEGFHQLGDQARQARRSLRYMILSKISTDSPDELATLLSSKSVLEYKGADVDALRGIADAYNKQDTHLFNSILAKCRTEAEESGAGGGSDTNLLADEVVRRQVNDMYNTLLERHILKVVSPYNRVQIAYVSSLLKLDAMVVEQKLSQLILDRKLRGIVDQQHRCLILFDDEAAEASKPDKDGGEDFYDNAADAAAAADQAPTTLYQDALTALECYNTLVTALFDKINGKFDALVEENIAKHRGAKAKENEDEANRKNKRGGISSTKDAAADRSGKNDKSDSGNKPTRSGDKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHH0</accession>
    <name>A0A088RHH0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_041040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="AIN95427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703749.1">
        <property type="nucleotide sequence ID" value="XM_010705447.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22572063"/>
    <dbReference type="KEGG" id="lpan:LPMP_041040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040017600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_041040"/>
    <dbReference type="eggNOG" id="ENOG502S97M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267599at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="80"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="345"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="436"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="486"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="618"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="809"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="967"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1119"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1257"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="142"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="372"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="494"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1135"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1193"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1286"/>
            <end position="1295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1295" mass="140445" checksum="7B52530DDC899F72" modified="2014-11-26" version="1">MLRPPAEHPRHKQHNREDTLYNKDDFDGQQTSVGVDGEAYTAPPHSAVTTLSPASPSRSLYADVEAAQQPLSPVVEALYVPPSTPTPAPSSSHSAVKRRHQESSTFDKKQRWEEKGEDDVEQVEAATLVTQADVTAAITAALRRYEKERDAEEEAVLQQVSKEVEEQASRYANLIEAYNTVCADRATLQEKLAETARECDELRHALQRSRQTQQALTDSAKRLEVELCHAKDLQQQQQRTLLKTEVAEWEAQRARYETRQGTLEAQLDQAREELRAMEARVSEKNDELAALRERAAKASTETANEYADIHLRMRQLAQNMATMEDALRERDTTIAEQAARLREAAERRESEVRAATAEREKTEAALTSARDALQRQTDDTRRRMHRVTELQHQRDALKEEEKATRRALQAASEDQGRVLQSLQHVLAIAKQSLSCTTDSAGHAGPPSSELSSRSPHRFTASWQGGHMDRTLVYEDDHEDNAHALRSCSAISPPESRSGSANCTPERSSTEEEDNARSEKLFSLSALAAEKKHRSASSPKSCSHRASHSPSVAAPSQRRARTSSPPQSARVAARETPAKYAKGSPSVHNTYHELHHRSSQALILLRELHRCVSALTLKRRKSSSGRDVAPSNTSGSFGRSGATAAKLQQACRYLKSELDRVQAALKETQAECQWRSLSMKKLEEDVQAARCGVLAAEKQRLACEMHVETAALVREELEAQLMELKATCAETTAGQRASEDAVAEAKAAAERSAALAEEAAQLREAAESALAREKAKSARQATSLRDQAAAQTALTDELEELKEKHKAALAQLQTHHAREAAQQLKQQEESHTRGAELAELRSVVATMRTTHGTAAEAWKTERASLGALVSSLETKLRALAETTMAAKRRCATLEEQLALHADVERTTLKTIGDIAHAPPLPPSLDAAAMGGDSYTSHAHDAVLPTEKQLFGGDDEAPEVEDVVVVSTEATPSGSSADRELARVASHTRTTTVRTTALSLVSARLPVSSATPSRVAPSTAVSPASAPPFGGASLEAATSSPVATLAPLRQHIVAAVHQLALEAVRLRQGSVLPTMRSPIITQPRIATCRPRDMTSSEGWYTGETAHDGVCSDAKRPCTAALSSPPPLEAFIAPQPQPRYQHQHQSPCTPHKLCPSTTSAAQPRTLEKAPQPIQHSDRSQIGGSPMPSQPSRHATAGSPSGSYSPPVSAATTAAVGEHIYNVTRPSSLRPQWSLSLPSSPPASHVTVATNGKLWNEARRSASIKDGLSGYSSSTGRGSVDGSCSPARPPSLRALSLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHM4</accession>
    <name>A0A088RHM4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_050360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="AIN95477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703799.1">
        <property type="nucleotide sequence ID" value="XM_010705497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHM4"/>
    <dbReference type="GeneID" id="22572114"/>
    <dbReference type="KEGG" id="lpan:LPMP_050360"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_050008300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_050360"/>
    <dbReference type="eggNOG" id="ENOG502SJT4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273783at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="333" mass="34757" checksum="7C930204EAE4D791" modified="2014-11-26" version="1">MPSDRNLSGEGFSNPYENTTLVGNWLEDRLQQRIVQKGRGGVGTTWCAQGVFEDPAVTRARDPAEAQAALLRSTYQVDYRNRRGVAQRTGSSGGTDCSGAASPLMLGTQHNPHAVGSGSTFSTAKGDGVDKVLLFSVDPVAGPTAPLPLSTNAGTYGAFYYGRNAGGLANGSSSHVNGALYADSATSPATSSPANKADGRVTAPPGDADSSLYDSVSRTAAAPSSTFGVTRAPIQRSANPDTTSSLPPVPQRRTLSNGTATSSTLGHRRWTLTSICASVAAGGFGAASGRSSQRHPQQSKDGMDDERWCSSKQIADMPVEHFTLQRRLPPVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RI24</accession>
    <name>A0A088RI24_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_060480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703929.1">
        <property type="nucleotide sequence ID" value="XM_010705627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RI24"/>
    <dbReference type="GeneID" id="22572254"/>
    <dbReference type="KEGG" id="lpan:LPMP_060480"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060010500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_060480"/>
    <dbReference type="eggNOG" id="ENOG502RBQC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275344at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="480" mass="53212" checksum="88C48D9D9E3F31B4" modified="2014-11-26" version="1">MAAGGKKGPAAAADPHGSAHGRHALTAFGARRSGELASYIQHGGDLTSQGRYLVVGDGLMAPFMALCLRVHGLECDLAHHPSQNDLDRGTVVLTPSVTQLMGDVLNVSVPSGSVVGRVLTFDHVGNDMCDIDLNEFREKGESPTFFCCDRLKVESALVSLCRIGAHSCTVLPKPQIDKGGLEALENGGVRVRFASGVQQDYLGVICTARNQDLVPELTITNEELQARAENTEKYRSTFSKSVRWMELCVPPLPELGKFEKRFTPGSQEIVEILTPRDAKMTVRPTMMATKLFYNVTLTIPDGTADPRLKSTSTKLFWDDVVMHWTSGVPGYISHTMFRPMFTHLQQNFTKSSALVYRTPLFLMPHWSEGGGRVIKVAHAAHGSCFDAVDVSDAQGFTDCFTLARTVAGGEDVAAFLKERRLLVMEEMDHHSRLTYYALKERGQMAYMMSRFNMKIMRKYKKSWRSILQNYITLMPKGIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RI56</accession>
    <name>A0A088RI56_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_060170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703900.1">
        <property type="nucleotide sequence ID" value="XM_010705598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RI56"/>
    <dbReference type="GeneID" id="22572223"/>
    <dbReference type="KEGG" id="lpan:LPMP_060170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060007000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_060170"/>
    <dbReference type="eggNOG" id="ENOG502SC3U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273896at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="405"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="442"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="566"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="595" mass="61890" checksum="7E003195D617C5F2" modified="2014-11-26" version="1">MTVSAAVSTSPYSVSLSASSLPRAARVGSEVRTPNALLDGACGEDNNSVLTNSEASDFYLTALVAQALHLEDYWVHLGHQIEVDQHVEFIQYCAREGFGALKTVHLLGWWRQYRSLVRGGADVPAGAAIGSLLLFDGNPQKTAPPSHFHGGGAGCGSAGGGELGLTGSAKAPKKGCRLSTSVVAGVPSSVEQDGAAGASPLLYATHAEALLGELQRFVQWELEHEWAWRQVPREPVTSAAVALTSPQAAGLSSGPRRTTAGVTAVGAAKPSRAEKVKLQQLQQQEMEAEEQRLARVAAMPPENIFLAKEELDDFLQFVVEEDLLSHTALHIYMTSHAEQPLCTLSRSARAPVCFSVQVETPMPVLPLREATRLSALPRGGGSINASASPTPRSGAMGGDATTGGSAAPQQSPSAIPAVGHGKPVSGRSRPHSKHSKNSSKDAAAAAIAEAETAAASAPPAAPELAVPLTAMEALRAEQAKEAAAYQAAYNEELAQAATRERAAQHAADVHLFFEKPKTNEAVQAVYASIEDAMAARQQRILQRVVALERGLGLTVPLAGANGFGGADAAATEPTPTSARGASSSSCSTPAKKKTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RI98</accession>
    <name>A0A088RI98_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MYND zinc finger (ZnF) domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_050780</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="AIN95520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703842.1">
        <property type="nucleotide sequence ID" value="XM_010705540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RI98"/>
    <dbReference type="GeneID" id="22572156"/>
    <dbReference type="KEGG" id="lpan:LPMP_050780"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_050012500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_050780"/>
    <dbReference type="eggNOG" id="ENOG502QY1G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.140.2220:FF:000028">
        <property type="entry name" value="MYND zinc finger (ZnF) domain-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="314"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="176"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN95520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="437" mass="47505" checksum="C3D24AE07656516D" modified="2014-11-26" version="1">MPPQAAAPPPPPRPDPVTLDQIFLQLTAVDVPCDSKTYYLVALNTVAFHPSVKLFLFEDPAAAAASTANADTRTTSSSSPAAAALNKQRREKLLKSVAFMLAQRNNVMCHESRWETVSLLGELCRMESAHSGAPTSALGQIEAKLNNYAKENLEYLAQLPWFLPTINSIIKAGGGAVDDEAEGDAGEAAATVDKARQQGETGTSAAASSSSSRSTLKERLKAAREAGRGGADGNSGSGTGAEEDEDVVIALLDIRRALPTCHRISSSSSSDNADVVVEWSDANIEQARDLMFVDASTSMLHLIPSVARGCSDVCAQCQKRVPTVSTSAAKQLLRCSSCKAVYYCSVECQKTHWSTVHRTPCRAYKERCDSILEQYYASNRANGKKKGLKRDEVVILEVPLEPSLFFETRRYLYDHRNESFAHVDYSDYFMKYTVRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIK9</accession>
    <name>A0A088RIK9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ASCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_080070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="AIN95817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704139.1">
        <property type="nucleotide sequence ID" value="XM_010705837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIK9"/>
    <dbReference type="GeneID" id="22572469"/>
    <dbReference type="KEGG" id="lpan:LPMP_080070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_080005600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_080070"/>
    <dbReference type="eggNOG" id="KOG2845">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="338816at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd06554">
        <property type="entry name" value="ASCH_ASC-1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.30:FF:000006">
        <property type="entry name" value="Putative_zinc_finger_motif_-_C2HC5-type /ASCH_domain_containing_protein_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.30">
        <property type="entry name" value="Hypothetical protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007374">
        <property type="entry name" value="ASCH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039128">
        <property type="entry name" value="TRIP4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12963:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12963">
        <property type="entry name" value="THYROID RECEPTOR INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04266">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01022">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ASCH" evidence="2">
        <location>
            <begin position="490"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="629" mass="69333" checksum="B275AA0DB2723FE7" modified="2014-11-26" version="1">MPPKRWAKPNQKGAYGENACTSDAVLHFICNGIRSDNFLGLSEEELTGMATELMHVKTRAEVAEWAKTLMLSEAFAAEVTKRREQSGPAFEGEIVPNTPSCLSASTAGGECGTLNATKRVTGASKRSKRGVNVNHLPKTSSATEALRPGRFECGCFATVHNLRGSCANCGRIICEQEADEVCYACGLEPSRCIAYEISVQEGRLSEAAQQRNQADYKTAVEQRDRLLEYAQNRAKRTTVIDDQSATLFSPQSTWLLPEERRAAEKSAAEIERQHNIELMHRQRGTYQVHMEFVSQNLPLGARKENSGGMDAVPGVAEAAAEDEETGGAGEIVVPTGAEPLPSLLHKIWYSPDGRRVESEPSGKRDKNGGGRCSSVVDVNLPGQEGTSVPLTSRPTQRHFDDVSRRVQQHYFEDDVEVFAAEAEEAERAKSELIVVPQALLTEEKGSAMEYDTEATNASLHPELVNRSAATLSSRFAVTTIMRNTDDGICLSMHQPWASLLVAGIKRHEGRVWGTTYRGRLWIHATSSKPTNVEEVGAYYSKFVAPGQVLPKHYPTKVLLGYVYVTDCLDREAYEAAFKPAERQEESPYSFICVEPKVLPFPLPMNGSHKLFTLEHRVHTAARKQLGEAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIM9</accession>
    <name>A0A088RIM9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Isochorismatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_080330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="AIN95842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704164.1">
        <property type="nucleotide sequence ID" value="XM_010705862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIM9"/>
    <dbReference type="GeneID" id="22572495"/>
    <dbReference type="KEGG" id="lpan:LPMP_080330"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_080008100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_080330"/>
    <dbReference type="eggNOG" id="KOG4044">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269496at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050993">
        <property type="entry name" value="Isochorismatase_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119">
        <property type="entry name" value="HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119:SF3">
        <property type="entry name" value="ISOCHORISMATASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="2">
        <location>
            <begin position="23"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="221" mass="24735" checksum="689050F4C565E5C1" modified="2014-11-26" version="1">MSRTALIASRSRLLHKFDSCRTIFMCCDIQEKLRGRIPNFQAAIDVSNSMAAIHNALTPRHTSFVATEQYPQGVGRLARDIQLPEGTPVIEKVQPSMLVPEMMPYIIGDPARGILPVQQAVLWGHETHVCIMQTADELLQHGIRVGVLVDGCAAQRQLDHDVAIQEMSTWDNLTLTTTISVLLQLVRGDYALRRPLMKLVVKPDDPSRFPSRTEDGDKQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJ72</accession>
    <name>A0A088RJ72_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HSP70-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_010640</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009370">
        <property type="protein sequence ID" value="AIN95164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696706.1">
        <property type="nucleotide sequence ID" value="XM_010698404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJ72"/>
    <dbReference type="GeneID" id="22571793"/>
    <dbReference type="KEGG" id="lpan:LPMP_010640"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_010010200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_010640"/>
    <dbReference type="eggNOG" id="KOG0104">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262720at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034663">
        <property type="term" value="C:endoplasmic reticulum chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF3">
        <property type="entry name" value="HYPOXIA UP-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="874"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1036"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="932"/>
            <end position="952"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN95164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1110" mass="118340" checksum="E058F5A622D3ABB7" modified="2014-11-26" version="1">MPFSSSSSLPSGQRCGHRRPAHRTQPLPLLRLLSLVLLALSALSRRRTSALFALATGDAGAAPPLLAIAETELISIDLGHESMKVSAWRVQQQHAPPSVVVEGDVAAAVPTSTGTVSVVLNDQANRKSPPCVAFRYFRTPSAAPTTTSGGVHNDTSPDVLDSEEESHTHRRCTALHPRGYQLERTFAEQALALAPRFPTQVVCSAAQLLGYTAALPNATTAESRMHALTSGQLMMNYSFHVVPLTALNVTGTATANGVDETQQQQERNSVVGRQALGVYVPFFTTSNAPGQLWQRMASDRSTVSAAESKGALFSSEELTAMLLGYARRMAEKADTADNALSEEDQRLVENMRKDAGNSIGNTDAAAGETGTVSAPTSAIRYAALTVPVHATVAQRQALVDAAALAGLRVVRLVHSTTGAAVQLAYAKAEQVLKSDKVQYVMIYDMGSQQAEVAIYSFAALPAAVASRANLQGALEMQAIVGSRTLGGAAFDECIASHWDARYFNRRVLSGVLTAAGGSEAERREAAKERGSLLRAAQRAKEMLSANNEAHVTIDGVHADPSHFDPMGQQELLQRRVTVTADGGLLSLRLMRRDFEEWCRPLFDAAVALRDEAIAATGGVVKNLGALSRFEVIGGGTRVPRLLQQLGEGYRSGIVDRTLNSDEAAVMGTTLLALSTAPPELRMRGSQALPRYNVREWLTSAVYASVELRSARTLATAAAAAPPEVQLLFPALKVVLPATRSLRVRVPDVEASPADSVIITLYSGAEADSAYADSTRSSAFATANCASCYVRTCTVEGMHKAAEQLLAQFTQQNMWHSSANPHPTHARMVGAEVVVEVVATVSGIPHCSVAYLRAEIEEVGAGPNIADDVQGNDAAVESATEVSLGNSHHDDSASGASQATQEDKLGEGEGEGGVDKVNTSEIEVTRTDARMNADSSADPATNRTSASSTSPPHESQPPPQVQVRVTPLSLRVSSGATAAGAAEHRLSYNMDSAELDFSHRRVRQLQALDDVRLRRSTLRNEMESMLVWIKEHNPTWNTEDAQASDGPSPPAEGAGHTLPQRSALQTWRAAVRQVSEWLDDFGDTASATALEERLRIIAGVKAALREAARHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJF5</accession>
    <name>A0A088RJF5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_091180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN96033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704355.1">
        <property type="nucleotide sequence ID" value="XM_010706053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJF5"/>
    <dbReference type="GeneID" id="22572688"/>
    <dbReference type="KEGG" id="lpan:LPMP_091180"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090017300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_091180"/>
    <dbReference type="eggNOG" id="ENOG502S3GH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="251018at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="657"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="710"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="712"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="741"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="771"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="972" mass="99603" checksum="A0D25FDA189FFAE6" modified="2014-11-26" version="1">MHSSTASRSKQAKCHPTADGAAAATRPTTAARKTVFKMQKTSPVVAATLSSPKTLQAPKEPIITIISSDGEAFSLSPSSITHSHLLEGAVRRWTEVYQANVQVPTGTFGRATGALCTPTDASSDDATADDLEETPDENYIARFYEETASDVTATSGVLEEVNSSGAAGSSVAALSLDRGIDDDDTTSRHRQERPRVIRKACALSNEEEDAHHPKRGATSVSRRAAGDATNNVRGVDSGDTDSDRTVSLLPSSAEGSMSNTSSPLKLHSNGGTPTRFSDAVGVVTEVAGAAPPNHVLPPGPPMRMPASPKLTASLRRSPAALTAPASRGSRLSPLALLDTNQSTPSVLSGEEGEEGEEEQGSGGSGAGAGGAKPPSRDSRNLGDEGLDDVAVTSSSYRLPSPSVGLATITASAVPNGRGPPHHKDPVVSRTAAFASHAPSSPGGGRSKNRQCSSTVVQVSAAEADDHFDQTAKGDACKTGTAAAAAAMTSTGSVRSGGSRPSKPSTPSEWNSPSSCHQRTPCMTDEDDVGAMMSEDGVGAKSSTPTKHGPSQTDCVGGSSLVNRPQPAPGAGGGTTAPLPPPTERTPLTSATHFTASAGAAAMAALATNTSGADAVAADPLKSSLVYDDGICITSGAIVFDLVRSSSRCESPRSRGAAAAAPVAKSVASATSAPPTATASTVSIRSSTLLVCIKYMKHFAETEAQAAADKAAAGKHCKRRRRKLRRSRHGNGSSGDDDDNDSSATGSSSSSSRVISGSSSNSSDRDDHNTEEASTASDSSFNPMSIESRSDGDAAGKGSLAGNARGATPGTSASTPGGPAVIPAPLTTPLVALLSPWEKNFLYMDVLGAPEAVLAAAAAILDVYPDFDYVSPSMPLGDAKVKAALMTPPPPPEGVQTLMEVMAAAKQLQIDPLHALCAGWLADFVIRVSYGAADNFEAAHLIRQCLRVPSDWSRRETDCLKIENEWPTNEEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJW9</accession>
    <name>A0A088RJW9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_111080</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696955.1">
        <property type="nucleotide sequence ID" value="XM_010698653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJW9"/>
    <dbReference type="GeneID" id="22572973"/>
    <dbReference type="KEGG" id="lpan:LPMP_111080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_110014600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_111080"/>
    <dbReference type="eggNOG" id="KOG1311">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF448">
        <property type="entry name" value="PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="9">
        <location>
            <begin position="293"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN96302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="443" mass="48782" checksum="0BB88B7152E31A5E" modified="2014-11-26" version="1">MHMTLHSPAEVADSPLPIHHVQQHLLGAHGSSPYGSPPKDAAQQRSSSARGDHAPQASLVANKLGSASVCEGEGVEAETVALAEVQQRGPSPTEAGANDALLKCVGLGAVDSERNVDEEIDAKGGSKRDEASGSGSRDEIAFALSGMHDACVVTNVLAPPSERFAVGRNVVSSNHGAADGIDGFESRSDQPLTSCCVDRRCYPDSWRQTRPRRHAFERPLHSYQIAGQIYCLVIVILFWSSVFSAYVLLYTQDKQDCMAELVTFALLVLAGTIWLYGSLILISFRDCADRSNTGELCVFCRRCTRLSSKHCKACNKCVEGFDHHCKWLNMCVGRNNYTLFFCFVSGCVFSNFATLASVICLLVRWWHILAKNHNAYFRVGPIVLCFGVLVSLGPIVYLLGFHVYLHLILKTTTYQHMVGKREETFQILVEKEPQKTQKRCFCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RK96</accession>
    <name>A0A088RK96_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_130170</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="4"/>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697100.1">
        <property type="nucleotide sequence ID" value="XM_010698798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RK96"/>
    <dbReference type="GeneID" id="22573127"/>
    <dbReference type="KEGG" id="lpan:LPMP_130170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130006900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_130170"/>
    <dbReference type="eggNOG" id="KOG2747">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF161">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="6">
        <location>
            <begin position="185"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="507"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="516"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="545"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN96447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="622" mass="68125" checksum="B4FF51959D0CCE11" modified="2014-11-26" version="1">MEVGQRCRLRIADCTSTQATQSSDDHHNDGFAVTGIVVGVRPHAEEPWRLLYYVHCTHIEFGAELARQRRKAAALSWSGTPLGTVGSGTIHSCNELRAISGSFISSHGYHYRYDGWYDAFALAPLSARAAVTNNTAAMTSASSLPPMGSATVPEPCDDGGAVPVSTVSLLPGEHCEAQEWVAAMERDTAVCEVVYLCYSFQPWFPAPYGALEYLALPEDDVCHSVYVCHRCLSPFFTREQYYVHLAGEYCRLRTPPGRLLYHDGDAGYKVFLVDGAKNLHYGRCLSLLGKQLIESKLLLNDVDLYEYVVVTIPRASLPYIPAALASCTSAEEPGVDTSIALSSEGFRRTASDFDAEGWDGDAVMGYFSRLKHYPDHTLSCIVTLPMFQRARVATFLLDVAYWMTRQRQRVCGCGFCGKSGGAISRPFSPHGESLLLSYWRCALLRSLAAVAPSYRRVSRTAQPELRFTLEELRALIDIPIHTDDLKTLLLQSEFAFYQPIAASAVSTRDCGDDDSASPLTSPTSSTRRPRRKHSRAPASLKDSKASGGSQASSSLAGGIAGNGGSSAPCARYTATLVLETTLLEAVAKLPTKAPHSCVTFDKRWLVKDERSAYAYDVPHYHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKC0</accession>
    <name>A0A088RKC0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_130430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697125.1">
        <property type="nucleotide sequence ID" value="XM_010698823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKC0"/>
    <dbReference type="GeneID" id="22573153"/>
    <dbReference type="KEGG" id="lpan:LPMP_130430"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130008400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_130430"/>
    <dbReference type="eggNOG" id="ENOG502S1T6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="246439at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="22167" checksum="B38DC419241BDE51" modified="2014-11-26" version="1">MQTPEGTNTSANPAPILNNKSIGRSVSYDEIYRAAKCSVLTDFYREKRYLDRRRRIAESGEDVQVIPVGSGDGAISPALVRPSTSRLLKEHSSASWSVFFYQSGVYGLTGISSICTAVALYLGIYQNRLVLPVVPMGVAVTWRLWGVLENVWNEQRYINNAAKMREERQGNPMHAVVKRRRKLDATTKEESPAAELME</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKF4</accession>
    <name>A0A088RKF4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_120960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009381">
        <property type="protein sequence ID" value="AIN96423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697076.1">
        <property type="nucleotide sequence ID" value="XM_010698774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKF4"/>
    <dbReference type="GeneID" id="22573102"/>
    <dbReference type="KEGG" id="lpan:LPMP_120960"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_120014600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_120960"/>
    <dbReference type="eggNOG" id="ENOG502SM16">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267299at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="622" mass="65120" checksum="7FF41F5A10F3A5C9" modified="2014-11-26" version="1">MRQPSSRQRDGPPSRSPVGRRGVPAVVPHGSLSGDFETPPPPSRRLRSRSSPFDTAPSPPSFPPATGLGISVVSVQPCPRSRPVAQRRTMMSVGKARAIARIAPQTSRLLSSRETRLRREHISEGQPGSHSADAATPRRLLMRRFSGGVASARPPAITSAQLVELPSSSGVTPASFGIEVAGLTTDHAPRRPLGASQGSALSTSLLFTFPEATPPAPTVAGTDGPSMSGQESRTVSCTFPPTQKTTRTSLSTSSDAAPTAMASASLADSVPLIGAHFTTASGEDDEERTLGSLSASQPLSRFTAMREPSTLAASTRSPPMPSIAMHGRLIPSVTSITDSLHCSTTTDTAATPRRGSCLVWLPAGSAMDFSGCSSTTNPKSFTDELRSIHTSALITDDGAHHCQCSAEPASQGMESDGDVPAPLKAHLPSTSPLPHDPVAGHTWRAEFMTSRHAVSGALHVAHTPVKHPPRTVLPSSARTVKTSIQSQRVSARSVGTHGAPMRPPLPREGAIGGDGDTGTTLSGCDACTAVSYSPNLTHPPHASPRGTPHRVSNSSDRLRSVTPTMTATGASNSGASPRTKSPTGTLSAELTKRAIKDRRRRELYAWNEQLRLQNESSVQDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKS7</accession>
    <name>A0A088RKS7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_131100</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697191.1">
        <property type="nucleotide sequence ID" value="XM_010698889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKS7"/>
    <dbReference type="GeneID" id="22573220"/>
    <dbReference type="KEGG" id="lpan:LPMP_131100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130015700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_131100"/>
    <dbReference type="eggNOG" id="KOG0378">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269064at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06087">
        <property type="entry name" value="KOW_RPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000041">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.740:FF:000001">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00485">
        <property type="entry name" value="Ribosomal_eS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000876">
        <property type="entry name" value="Ribosomal_eS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032277">
        <property type="entry name" value="Ribosomal_eS4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013845">
        <property type="entry name" value="Ribosomal_eS4_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038237">
        <property type="entry name" value="Ribosomal_eS4_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041982">
        <property type="entry name" value="Ribosomal_eS4_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013843">
        <property type="entry name" value="Ribosomal_eS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16121">
        <property type="entry name" value="40S_S4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00900">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08071">
        <property type="entry name" value="RS4NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002116">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 13" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein eS4 N-terminal" evidence="11">
        <location>
            <begin position="3"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="10">
        <location>
            <begin position="41"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Small ribosomal subunit protein eS4 central region" evidence="9">
        <location>
            <begin position="92"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="8">
        <location>
            <begin position="175"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Small ribosomal subunit protein eS4 C-terminal" evidence="12">
        <location>
            <begin position="209"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIN96538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="273" mass="30638" checksum="FB7447105E4D98B9" modified="2014-11-26" version="1">MAKKHLKRLYAPKDWMLSKLTGVFAPRPRPGPHKLRECLPLLVIIRNRLKYALNAREGEMILRQGLVHVDNHPRRDGKYPAGFMDVIEIPKTGDRFRLLYDVKGRFALVSVSEAEAQIKLMKVVNLYTATGRVPVAVTHDGHRIRYPDPHCSIGDTIVYNVNEKKCVDLIKNRQGKAVIVTGGANRGRIGEIVKVERHPGAFDIAHLKDASGAEFATRAANIFVIGKDLNNLQVTVPKQQGLRMNVIQEREERLIAAEARKTAPARGARKARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RL96</accession>
    <name>A0A088RL96_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_140850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697316.1">
        <property type="nucleotide sequence ID" value="XM_010699014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RL96"/>
    <dbReference type="GeneID" id="22573352"/>
    <dbReference type="KEGG" id="lpan:LPMP_140850"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140013600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_140850"/>
    <dbReference type="eggNOG" id="ENOG502S8HE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273903at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="172"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="388"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="591"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="727"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="463"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="490"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="507"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="593"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="755" mass="80621" checksum="0C19C08681B1A742" modified="2014-11-26" version="1">MRFTYASSCYLVQLWARFGNPVVAVDRWRWSESGGEEGHGKGEQWVPTVEEACAEYHRVTVGVLQLRRQQLLDVVQLQQQCPVGESSAAPSPAARATRGDRKRWTGVTVDEGSSAVAECTSTTAALRQVPPFVASFDRYALLQHTAAAVLTDDPSAAPAPLRRVCSSATLKEGGPSMSLLPSQPSPPPIPPSSDGSSATLAATVSGDSGALALDVPLAPPLAGPTVTAQERLTAQVTPNSWFAHDAEVHRRSCLAQLLRQEQQMNVPYQLAANRYLALAASTALALQRAVFAFYSRDDEADLAEAPARKNEVDMRDSTDRAALREATVPPGSSSLALHPPGRPPRSAFTVQLQPLPSVDPAAWRTAEVTVRKAAAEVLGTVNSAFPAAGVASPSRHPSRPAATAVGSQKRARSATTAHVATSGRRRGRVAVAKSVEEGVAADVLAQRKGNGDSDDEVAGSEVPASSETGSEFSNDEQDHEGSVAGEDADERVKIEFMGEQRQRHPTRSSPRSTSSRLRLSVDTGTAHSQASHLPADATYAALQTYITDVLPFRCARLRGVVQAGWLLPAPPALPHTLTDPVEEEEVGAIDAQTRGNTTAENGPTSAFPLLSSSPQPEQGPVTGNTAAVAHSLNSALLAPILTEEEYQQLRKVNTASVCNRVVSHTDEAVLLSLPSTVSRLHREVEQELERYLYEDTSALMEVNPVAQSLVGAIRVAYTQNKLLHRIAARLEHVLDGLKKVSEECEEEAQAVSRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLK3</accession>
    <name>A0A088RLK3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_150860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697461.1">
        <property type="nucleotide sequence ID" value="XM_010699159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLK3"/>
    <dbReference type="GeneID" id="22573506"/>
    <dbReference type="KEGG" id="lpan:LPMP_150860"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150013700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_150860"/>
    <dbReference type="eggNOG" id="ENOG502SGFB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273647at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="948" mass="102006" checksum="DDC4AB9C7ABF7CDD" modified="2014-11-26" version="1">MMRLSVLSRAAWRHTGAQLAASVGRKSSIATAMNKTKTAKKRSASSRVTSRRGRASPARLNESMTGAAGSRVVVAPPDVATTDVARTNAHVTSLHKLSNTTSLASSAVYLARGERKTRVSSLDSHASASFPPPSPPLRPLSALPTSSPPPIPHVNGCNVSVATLQRRIRSLLAQLVLLSPEPLRPSALFARYRDAVDEETASMCAWAAHAVYRYDHGLLHCGTNGASHAACRGVLSEGEAGARDVERQTAGTTEDNANSGSSCGGGAAVEQRVLWRRGQQLSQAFRTSVVPLVTALGRGGGSGGTEMSVAPRLPASHEVEQWMFLSIIFSDAEFRVSPYSGAVSYPALPSMLLATVNPLRDREVAKLCYALQWGVQAKAAAYAAFCETRDTSGMKYLSGTAIRKHEQQSPVPSATAREEVADTCEFVWLNGAAGSPTWTTAHAQYLLHSALAGVRKPSDESATRSVAPTTGFSADQQLRKTISAAARQQHTSGHPLVDVMLHASSVVGVATRGGGSQTSEANVFMNSGGTAVGTTRGSAAAAAQPPALGWNEGKKGTDVATSFAADTSEDGLFAVMMGDLPTRSLSAGAMYEINRRLIAHLFRKFTAIPIPVARLSTAVRWNLSVAHAAQFRSFLYFLLLTSANPMVHRMAEGQRHRRRANALCADVWGRKRGYDGEARGGVEDEVRNALAQYDPRTFKCLQDSGTAEGSTVAALRRAFVADAEVTEKCEHAPTTVIETMCVRVLPHARPGQWRTAPRSPTCGAAAEASVSPAFCGYPLRFIEVLPTWRQTPEEVLQYLWRQQDQAQLCSKDASWLENEEPYILVFSLDRGVLDTRLRLVIDRYLDLRNGAAASTVPPNRATLARVTLRQLGVITLWAHEYGAEMAAELLFVHLLPRHEEVRLHPPMESGHKLWGEETHKQTITTSGDETNSGSGSGYGAWTVEFLPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLS0</accession>
    <name>A0A088RLS0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_150210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697398.1">
        <property type="nucleotide sequence ID" value="XM_010699096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLS0"/>
    <dbReference type="GeneID" id="22573437"/>
    <dbReference type="KEGG" id="lpan:LPMP_150210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150007100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_150210"/>
    <dbReference type="eggNOG" id="ENOG502SH23">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267464at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="291" mass="31287" checksum="A188698121405BBF" modified="2014-11-26" version="1">MSASLPADERPTMLPSLPAQAASPTAAAPAEVAAASRSGTSITSAERDSPPSERRAMSFEEFREFYVASRRSNYVSSQGNTAGSLVRRNDGGVPTHDTGDADALTGKAPGQLHVVGALRRRIVGTDDDSARPAQTAAPAVTPPPVVHAPPAPRGRLARGARAVGGWMSWLANQAMHNRTHLLQLLLIFFVLYVHVKLSSAHLLGLIVLYVVVKGMQVLIRNFQITHEAGTIGAPSLLGRFFKPEGHVGPVSKLRKIGYVVTKCMEAFLLSFFPTYSLEHLERELRADGIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RM05</accession>
    <name>A0A088RM05_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phenazine biosynthesis-like protein, putative</fullName>
            <ecNumber evidence="4">5.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_170440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PhzF family.</text>
    </comment>
    <dbReference type="EC" id="5.1.-.-" evidence="4"/>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697735.1">
        <property type="nucleotide sequence ID" value="XM_010699433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RM05"/>
    <dbReference type="GeneID" id="22573787"/>
    <dbReference type="KEGG" id="lpan:LPMP_170440"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170009900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_170440"/>
    <dbReference type="eggNOG" id="KOG3033">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="75169at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PHENAZINE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774:SF17">
        <property type="entry name" value="PHENAZINE BIOSYNTHESIS-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN97082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="532" mass="59256" checksum="3E629E152DA080FC" modified="2014-11-26" version="1">MEPRHVVVSTPMMVCDAFTTDRFKGNPAAVCFVPTSVYCMEWSALSSLEASLGRGEPEVLETKMTEKDRQAAAEKYAVERNAKMGRAFQQVAKEMNLSETAFVYRLPTSRIRTIHEQIMRKCNEFEDEYEEKVKHENEERRRMSTAVTEDDEAPVIVVQEQSHGSVLSAIESSETPTHQSKRLSSLGAPPSPGLLPSSSFSMANSGVSFLYTRASNSIMVGSEMCRRPRRMHAQWFGLRWFTPTKEVPLCGHATFAAAHAIFEVSRLVQSESTRHLVSHIPMEFFVPAQTDVLCFVTESGVISVRCKAEPIIKPSDLVLHSYTCPPDMYEVHFPMTEAFSVKEAVPKDLYSDVAAALGLMHGAGCVEDIAYSKSTGYYIARLSTSQNVLECHPNWEALRRAFSSPHLMHALKEHSGVLGHIKGLGVTAQSDGHMIGPAGSVDVVSRFFAPWMGVDEDPVTGSLYLAILPYWLRLRQKGHFKVGDRLQFYQASKRGGFMTAIVIGRKAERVALIGPVLTFMRGNCTFEVEEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RM69</accession>
    <name>A0A088RM69_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Adaptin-related protein-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_111000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696947.1">
        <property type="nucleotide sequence ID" value="XM_010698645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RM69"/>
    <dbReference type="GeneID" id="22572965"/>
    <dbReference type="KEGG" id="lpan:LPMP_111000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_110013800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_111000"/>
    <dbReference type="eggNOG" id="KOG1061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="7">
        <location>
            <begin position="24"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="248"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="263"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN96294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1000" mass="109708" checksum="A269502CCDC3C800" modified="2014-11-26" version="1">MPTAFVTGVAYFNRGFDTPMVREDLASQNEPRQLSALYHVVAYMTMGKDMSGLFNEVSALTSSTNSTLKRLAYLYLVENSRAQPERTVLQAGTLVKDTLHDSPLVRGAGLRTMTNIQLPVMADFVTGPLHRCLEDNSAYVRRVAAMGVLKHYAEAPNVSSDSDLLDKLKGLLKDTNAAVTGSAVRAILELQYRNAPVSYIQALLEARSHFIRMLLLGNEWTTAYLLEGLAIAVMWECREAVLKSKGEEAGCGRRRRREPPSPVASSTGDNSSSEPTSPILRHAGRPGAPDDADDDELDTLRQQYITEGEETLEAVLPLMQYASPIIVLSAIRVVGLFLHAVTSSRLRVPEAEQSRLLRRYALSLVQPLMEMLEAPRFEMRYVVLRNIVQFLTPVFTPYLTAHLSKFLVKFEDPIYVKMEKLNLLVRFSNRENGARVLDELMVYTREEDVALVRTAIKAIGMLATTLPELSEECVRQLGQLITTGVPHLVEDTVFVVQMVLRCYPGKFTAIIPSLCASLTILEATEAKAAVAWVLGEYPDSVSESVTEYLSVLVSQFMEQPRLVQCATMTALAKLYLRGARMAPEKDSNSAIPNGAQAMLEKVLSECTDSLYPDLRDRAFFYWRLMTLDSGVAKRILASTEAVKLGSNSWDEFGHRFSQQPGTSSGLQELGTLASVVSKPLRLLIGDNVIGSSMKCLIGLSDDEDAEANGDGDRDEANGYAGGSGNGLSVGKAVLAVGASSSSTIAHGAAVAMPPSSETTTSFSTVLTPVQGNGVQVEMMWSLWGSKLVLCCRLRLVPGEDYMRHTRVLTMQINWNMFGLGVAQVFSATSLECDGKPAEVSVLVACNNQRSPTAELQVAIELELIGVRYVVAPPIPAAYLLLPATGCELHFFAEQWRALGHSVWNMPPQLHELKCDLTRLTTNLLRVHCLNLVHRHELPEKGLVLLLLYCETIGHEHLLSQATLDMKEGTLMALSMRSADPPVAAYVGEFIMRALCPPSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMM0</accession>
    <name>A0A088RMM0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">60S ribosomal protein L18, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_130450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697127.1">
        <property type="nucleotide sequence ID" value="XM_010698825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMM0"/>
    <dbReference type="GeneID" id="22573155"/>
    <dbReference type="KEGG" id="lpan:LPMP_130450"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130008600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_130450"/>
    <dbReference type="eggNOG" id="KOG1714">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="261402at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000039">
        <property type="entry name" value="Ribosomal_eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17135">
        <property type="entry name" value="Ribosomal_L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="6">
        <location>
            <begin position="2"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="150"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN96474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="198" mass="22080" checksum="940C247E41E341DA" modified="2014-11-26" version="1">MGVDLTGISKKSRVVRHHTYSTNPYIKLLIKLYKFLAKRTSSGFNKVVYQRLIKSRSNRAPISLSRVAVVMKRKAVFTAKCKKAPIAVVVGDVLDDVRMARIPAMRVCALRFSKNARQSIVAAGGECLTFDQLAMIAPTGKNTYLMRGRKSGRESVRHFGASGVPGSHSKPYATNRGKETKRGRRPGQSYKRKAFRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMU9</accession>
    <name>A0A088RMU9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_180420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697876.1">
        <property type="nucleotide sequence ID" value="XM_010699574.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22573932"/>
    <dbReference type="KEGG" id="lpan:LPMP_180420"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000038600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_180420"/>
    <dbReference type="eggNOG" id="ENOG502SKCN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266322at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="949"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1131"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1256"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1614"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="956"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1262"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1282"/>
            <end position="1308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1679" mass="178111" checksum="AB538BB7FB07022E" modified="2014-11-26" version="1">MRISSTLNRGAGGRIHIGAFPHGGLFVTPVATAAATIRASGAVALPSSESCVKRHPKGEVLAQPRTFPKDDNNGTACGEEGTFCSWSIQSALQAAYPPLPLVTAFYGHRARLLPPRYFYQRDLLSVSDHGCTTSPAAARGGSATVSVGSARITDWGSEGDGSGAALLLLYDVATLPWAAGAGLTLTLRNAVLSAHDEMARQETLAASGIKGNGGEHSRPSSASPVTARVGSGAAEHRRTLSIATMKFSPAQSEAEGEDKKNAATSSSTTTDAGDHTDRTVWQLFSEYRKPQACAEASALALCSFAVVKLGQRVPLVALVAEKACSAGTTFSSLTEPCVTHRASGMYDQQRSNTPAWLPPRTAVHRMPVEVYAERTPLMQTAGTAALQRALRQALNRVLPASPRPSPLPLFGRLRWCISPLAHLIWNGRCWVEETDVQVAEMEERLLGALMGGCDVHAVVATADAVRSAASRNTTMCGTPAMRSDTCDSGAAGRLAALRTDLNAQGSSHPRFWLPSCWYHAGSSRGVLTPLFREHDDGNAGIGTLCDLPGATAAPAASWCGPSSSPHVVWRRTNHCTQVGDEAVEAAAAAARAPVALAGGARKPPAIPCSQWLLRLRKVWLLSSPSVKSAMLARAGTEMRAGISTPPSIGDTDVKPVLPLLDAARGARDHSRAPSSSLHAPVPVRYPNYDLFTGSPLDLRDYDAAARGFRVSSRSPPTSRSTKLFLCPSRTAQPPPAQDCGVKVMQGATPQSESDPFFFAALSQQVGWIRLSPTCSPPRLHVGASSASAPMAAPGMGPVSWQLPNALHSCYTMPDSLADAPQRRLCSGTTPAAQAAAPRTTVASSRATAQHLPSVPQPPVASVSVPQQEWWTGFFLHDAPHWWRREVLQSEQQRWAAKRICKGKHAASVGRGHERDAERIGTTEEVARILLFLQEECRVPLPPINASDSAAAAACPSQDTPGSTSEPSPPVEVTQKRTTLPPQVYVLRLAPVAPVLRRPHRLVRRDEQGVQRHRWAPTDALGLELQWFLVPDTATATVNTFFSLQDVSDHVEASGTATGASPPTSLADRAVLFYLEVKAALELLRRITHRATAWEGPFDDEKGPLAPPSSPPAWWEQLSNFYDANTFLSEEAAPPTTVSTTDKGNKASGGDDSGGEIETTHSDADAKENAVPAFCHPTVAAVVRTCVRLMLQCGGPAHHRHVSNFPITLDSGGSEDSTASSEAIAVWSRTDYDALLRTALITPAEAAVMPSLTPRLRSAAADGDGDESGGNAETDEEGAEEAAPDREDHCVTRAEHDSESSRGEFAVKQETQRRCTASCGAAASTRDHGTSIRYVSSSAQGVQRSSSTLSCLPYGVEVYEYDESGTRDETRVSHGGPTLFLNDTQALANAPEDCSDTHLCPLHDRSAVDRRLLLGRNYRLSEASQPRKTPGDTGAVTAVCPASSIATCVTSSGKPLQARQLSVACVLSISAACKEAMRKGGDVGAHDGPPARCQLNSAELLVQNEKSVCSGGFQGCADGASLRPSNADGVSPTLSSASPSPPLDVIGALIAEEKDQFNTQWRPWLRYLPRPTMQDNTLPTSAQPTGPQMHMSRVFPFLKSSAASEYCIDSPLRAEATSDQDGGGEQHIENSAPPGAAAQSDGAVAVLDLGLCVLHVRRTDVYVNAANLVYKATGTKEQYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RN38</accession>
    <name>A0A088RN38_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein kinase, putative</fullName>
            <ecNumber evidence="10">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_190110</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="10"/>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698006.1">
        <property type="nucleotide sequence ID" value="XM_010699704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RN38"/>
    <dbReference type="GeneID" id="22574065"/>
    <dbReference type="KEGG" id="lpan:LPMP_190110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190009400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_190110"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4568">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000976">
        <property type="entry name" value="Associated kinase of Tb14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.190:FF:000019">
        <property type="entry name" value="Associated kinase of Tb14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="23"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="CAP-Gly" evidence="9">
        <location>
            <begin position="578"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="384"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="443"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="463"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="484"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="497"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="521"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN97353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="631" mass="68438" checksum="BE4A3A8170986ADD" modified="2014-11-26" version="1">MQPCSDSAASTGSNIVVEGKYTIQDANIVGRGAYSVVKVCTPIPPYVPPGSRAGMKYVVKIIEKEYLISLAKGDVEMAMAEIKREIDVLRHIPSHENVVTFLEYVETERQFLLFFEKVQCGDLCELILQSSSGKLTEEKSKLYTYQIIKAVLHCHLHDIIHRDIKPENLLVSEDDNIKLTDFGLAKRSRGVCTGDPSKDPLDVTALMMPYPGCERLLGKRVVCSDVIGTPRYGAPEMFYAKFTQTHYDGFNADTWSIGVVTYITLSGSFPYSPGSNASEKEVFRTIMGTPLPKPFGISPLAWEFVQSMLNKDPSKRTPLYAALNHPWLADVVVQRGSVVAAQLRSSVISADVESAAARFDEEARHLRICMAKLQGEVALLREERDRAREVQQPAFQETHTPARRAQTPSGLSRPRSTRYPMSTARVSSPARVVTHRRTGSRDSSSAGSLPRRSSATRGRSPLARSAGGAAVRRGTPARAGGTTPARSGTPFRTTAGRSGSAARTTITTRGATPTRTATPGHSANNRSRTPHSSATSGAANGITSGALHTTNAVNPANELHLGDQVTYKGCRAIVRFNGSTAFGAGIWIGLEMLEGNEGTNDGSSFIDKKQYFTCPKGKGVFVRASQVKKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RP18</accession>
    <name>A0A088RP18_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_200780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698277.1">
        <property type="nucleotide sequence ID" value="XM_010699975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RP18"/>
    <dbReference type="GeneID" id="22574285"/>
    <dbReference type="KEGG" id="lpan:LPMP_200780"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200011900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_200780"/>
    <dbReference type="eggNOG" id="ENOG502QU9A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268966at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="508" mass="58611" checksum="D8049763BE3CCDF7" modified="2014-11-26" version="1">MLRFSASAALRGASRVAASAVLSAHRQLVHTPVRSGKAALQPPAWIEQLRQDAKTTEKSISYDIKVYDELSWRRKRFTFDKELWDPMRMSSILRNRLCLGNEGAEYTVIGEAFVFPDREDSPIVNEPQRVCALLWDHNSSTEKVMIQLSEHFPPLLWHTVKPTLGALRKVFSEFLDVDAEHMKKYLPYYEEVQNRIETQMDEKLTGTLSPSHMKDKFIEDMRKRDPRSVELDYPNEYNIFLGLTPHFRVTEDQLMKKNPFVFGWPMLLSDGNEYLEDTPLRMAAFRTVYSKSLLMFHTRLDLQVDHRQTHLPGDDVEDILLEMPVFCTVNYPTNTRLSGGRPLVQRFNQVMGTSYPLGIPVDVLATFARESTVKGERELLEELKFLTAASQKAPELERVFRVSEDQLSSNKIIGQLAYTIVYLALVNYQKFVEDVFKVYWNHPSDLIRVACAKGAHIVERQDLVEQLIQAEPEGRCKTMLMTTMHLHTETHPAKAACSERKTAERNLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPJ8</accession>
    <name>A0A088RPJ8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">NADPH-cytochrome p450 reductase-like protein</fullName>
            <ecNumber evidence="11">1.6.2.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_202390</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="11"/>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698442.1">
        <property type="nucleotide sequence ID" value="XM_010700140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPJ8"/>
    <dbReference type="GeneID" id="22574448"/>
    <dbReference type="KEGG" id="lpan:LPMP_202390"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200029200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_202390"/>
    <dbReference type="eggNOG" id="KOG1159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06207">
        <property type="entry name" value="CyPoR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000045">
        <property type="entry name" value="NADPH-dependent diflavin oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000030">
        <property type="entry name" value="NADPH-dependent diflavin oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF10">
        <property type="entry name" value="NADPH-DEPENDENT DIFLAVIN OXIDOREDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="9">
        <location>
            <begin position="4"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="10">
        <location>
            <begin position="210"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN97735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="624" mass="68558" checksum="9DDC798EB036E58F" modified="2014-11-26" version="1">MTQLTILYGTQTGNAERLALRVARLALREGFECVSCLPADDVPIAEWRHTGGPVLLICSNANQGDAPNTFRRSWASLLQPTAAGCMEGLQYAIFGLGDSLYLKFNQMAKMVHNRLQQLGGTPIVMRGLGDESDAKGIEETLQPWLAELWKALERPGKYGAAAGVSAYPQEDLPFFPLFSIAPASTSDEVTVGAPSSSTDVTAASLPYFADHVFPCEVVSNRRLTSAACEQVVHHLELRRNSSSTAATAYDVGDALGIYCPNREESVEELLHLLQRDGTETVVVTPDASHGLVRQPTRPFFGRPLSLRSLLRHYFDLDAVVTQEFLWMLAHEVTGVDEDTHDVQERLYELANPSNVDDYLQYAHREKRNVCEVLHDFKDLHPSLELVLSFTTPMLPRYFSVASAPAMDGANRYDLCVGLLDWHTPLKRHRTGLCSSYLVRATPGTQLTCSVWQGSLALPAAPTPLLCVATGTGVAPVRSVLRQVAGLSAQGWKDVPVVLVFGCRHEAEDYLYREEWVALKEIGALPTLLVIPAFSRDADKKVYVQHKLGQHARLTSSFLQPEGAGVRPGVVYVCGNAKQMPKDVQHTLERIVEATVAEVHGEAGAAAYVRRLGRVGRYQVDSWSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQ08</accession>
    <name>A0A088RQ08_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_181540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697987.1">
        <property type="nucleotide sequence ID" value="XM_010699685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQ08"/>
    <dbReference type="GeneID" id="22574044"/>
    <dbReference type="KEGG" id="lpan:LPMP_181540"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180018600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_181540"/>
    <dbReference type="eggNOG" id="ENOG502SKCG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="278681at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="213" mass="23200" checksum="FA04577373CB8573" modified="2014-11-26" version="1">MSCNAGLLISVKGKREGELEIAHFPTKLTCSFSVSLAEVRRDEALFVLYRLRVKESSILFSKTYGLLGHDKAGRAQPSTWDEIALYAQPAVMEMGKLSTIRVEYITISEAEAMGLIERGEVEKEFCRPFFTRGDTKHYEVRCSFHDASPETAVENGSQKYSGGECTGGSRVTSAATAVTVLAAVCVAIGVIAARRRGITWEGAARAVHSWTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQQ5</accession>
    <name>A0A088RQQ5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ATPase subunit 9, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LPMP_210790</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ATPase C chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698867.1">
        <property type="nucleotide sequence ID" value="XM_010700565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQQ5"/>
    <dbReference type="GeneID" id="22574901"/>
    <dbReference type="KEGG" id="lpan:LPMP_210790"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_070017300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_210790"/>
    <dbReference type="eggNOG" id="KOG3025">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="251299at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033177">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, proton-transporting domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18182">
        <property type="entry name" value="ATP-synt_Fo_c_ATP5G3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.20.10:FF:000008">
        <property type="entry name" value="ATPase subunit 9 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031">
        <property type="entry name" value="ATP SYNTHASE LIPID-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031:SF0">
        <property type="entry name" value="ATPASE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0138">CF(0)</keyword>
    <keyword evidence="7 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="13">
        <location>
            <begin position="42"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIN98160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="106" mass="11106" checksum="7C7100205D6A7E3F" modified="2014-11-26" version="1">MMRRVISQPVTRRAAAASSVLVVTPRKASTVAISVQGLHYVGTGLAAIALAGVGMGIGTIFGSLLMSCARQPNLTKMLFNYAILGFALTEAIGLFALMLAFLMLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQS5</accession>
    <name>A0A088RQS5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_230200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699179.1">
        <property type="nucleotide sequence ID" value="XM_010700877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQS5"/>
    <dbReference type="GeneID" id="22575224"/>
    <dbReference type="KEGG" id="lpan:LPMP_230200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230006900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_230200"/>
    <dbReference type="eggNOG" id="ENOG502S69G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272305at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="270" mass="30343" checksum="08233964076EB669" modified="2014-11-26" version="1">MERNKLQPVVSAVQAEALSKPEDHPRRASPVWRVYRLRDACAALQLSLMAYECRHCSAHSMTVATYVDACASDLVKGVRTLEGDALSSLPTCDSSDAITTVTARWFYIGSETDGDVRVYLMLPTYADYFFDYTMHWARIAHAEMARQYVGHGLIAKLQTVGGGWASLHRADKSLMCALQLHTVAQAVFDEDVMRKSRLFIGWAYLWNCNPAKALEVFHGELEAARRHGNTAHERRCLHAIQNAEHNPFLAPGGAHTGHYRLVEAWWDVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQU1</accession>
    <name>A0A088RQU1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_211470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698932.1">
        <property type="nucleotide sequence ID" value="XM_010700630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQU1"/>
    <dbReference type="GeneID" id="22574969"/>
    <dbReference type="KEGG" id="lpan:LPMP_211470"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210019200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_211470"/>
    <dbReference type="eggNOG" id="ENOG502S6AW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="738"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="838" mass="93202" checksum="A996EB52B69D7C50" modified="2014-11-26" version="1">MAYPPHYHEQQQQRYSEHDVTAHVSPHLAALAEDVHRITGDISRPFRKAEYTMVLQQFDMLMASSTLEVVATMAVECREEMRELDSLGHSLNVLGPDFLTWRLTTPQGRAIGVNGNYNLPKPPTVSNDAYQLYVLEQRIEHAWGEVLLAAMRQLPDEQEHHDEIVNDFERLFERCSDYLRAMLQDTISTVHLLDVTVMDATELPTQFVVHAALVKHPPSNVTALVKFIQYLKQRSIPLSLAAAEQLERIYLRFMKGSAAADVFESVTAAGVIPLSVRPFAMLFNNLTDANAVLDAYDLMLDYSIAPEASTLRILCKQSRMEYAKLHFTTVLKSMTNTTSTSHSHSPPPSPPPPHSPLASGGAVAVAAHTNAPTITTASRRRDERSYFAQRIEWLAERKPKASLLEALKVLHRAEVEGTSLQGDTYIMSALLRHYCRSTTPRRHLVLPFSASLAYRPSPVSDDVQLTSDGETGGNSKGHPMTNAFDFDFDPTKEELLEKEGKCTIMEELEGPSGAPTRSRGGEPEPEKGRRSRPPPRDPYFADSSEEGTYILEVLKSYGSYPDNNVLQALSAQYEGQVPHMEIVASVVEAFFEGCMASHGAMTPVDCRFLHALGYYYIDNRWRDRAHHLVRRVLEMFYAYCVTFRADLGGTEKWFSYFAVIIGTKTGPLDLGIGLFAASIALSDKTVNPKVATKLTAKRDSSEHVIEVLSELERCGWDYHRILCCDALMLEPQERASAGKVESAAGANGAGARDHRHDRGTNGSGAAGEERLGKESIYTSAGQGPSSYSNSHLLSARPSLVTYMYVALRDLGVDKKTADWLRDRLKAARQEVLATKRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRW1</accession>
    <name>A0A088RRW1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA helicase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_240580</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699400.1">
        <property type="nucleotide sequence ID" value="XM_010701098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRW1"/>
    <dbReference type="GeneID" id="22575467"/>
    <dbReference type="KEGG" id="lpan:LPMP_240580"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240011700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_240580"/>
    <dbReference type="eggNOG" id="KOG1000">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2801544at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18010">
        <property type="entry name" value="DEXHc_HARP_SMARCAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000073">
        <property type="entry name" value="DNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010003">
        <property type="entry name" value="HARP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45766">
        <property type="entry name" value="DNA ANNEALING HELICASE AND ENDONUCLEASE ZRANB3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45766:SF6">
        <property type="entry name" value="SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51467">
        <property type="entry name" value="HARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HARP" evidence="7">
        <location>
            <begin position="56"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="187"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="466"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="648"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="692"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="786"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="960"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1052"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="649"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="661"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="692"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="721"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="811"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN98693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1096" mass="117608" checksum="038157EB6FF81E6F" modified="2014-11-26" version="1">MNCQCDYPARYLISRDGKPCYTCTLGRCRFYALAPVQCEGYTRITLGAPGCPLADTGVVLRFEAAVHPANEDAACFTIRVQGEASRWEALRLDVLQDPQFDGMWYTAGRAFLYPMTQYTHLLAALKARPLPHIAVEEIPNFYFRCVERMRQLPRQYADDVAAGRACLPDTEDCVYKLLRPFQRDGVRFVLERHGRAMIADDMGLGKTVQAIAVAHHYRGEWPVLVVCPMSLMENWAKEFNKFCGIPFARIAILQGAKATATSLQDVVIVSYSSLKCVEHAHFNVVILDESHYIKAGAAKRAQHSLKLCRESRRAILLSGTPAMSRPIELYAQLQAIQPGAVPSRAQFGARYCNSFVGRFGIDLTGHAHADELHSLLRHYLIRRTKRELGRELPSKSRQLLYIYITEKEKKALEKQIIALRHSLSSTSTAAANSAFSLVDNSAGDCAARAPNVFEMKMATARAKIPAVQDYVSGIVEQHLHSGEKLILFAHHQCMMEALRCAVEAVQPLKPIDYIYISGDTPPAQREPAAEHFRTEATCTVAILSMQSSGTGHNFTCASTVVFTELDWNPSTHLQCEDRVHRIGQAQPCRIKYLLAEGTSDSVIWPLLQAKLSVTTAMLETSNTSGTEMHLHDGADKQNVTRRDVVAIKSSSTPSTSQQSTLDQFIQPQPSQATPNREEEVDGVVVSMLTSPRVNVHSQPSTGHAALASPERDAPPLLLTPTCPSQRQQLSSTLMDTPISASRRSASGSGVTVTLTTTTMAPTTPPALIPFSEMGNNFLVTSMPHPSNFSASRRPRLSASSGTGMVHPTQPPVSLSTATPGPTSSSVNAASVLELMRRTSSTKSDAASAAVTPSSWVPSAGVSLAVDLTGTASTQSVVMQSLPSTVSRPAAGAVVPPRRTVFTLTKTSPNDSMNTPVASMVTSSSPATHALPRALPLTLPEAPKTGAVHVPLRPNLHLKRPRTEAQHGRGGGSDIRANTAGGGTQAFATTAVARVETICATGPAATAASIGSATWGPSASLAAAATLAPSPPSTLLPVHTQAMIVHPIMLAASSSSPTPSPVSTTPSPIVSAPRRTLFKLGSNVSGAPSSPPPARPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRW4</accession>
    <name>A0A088RRW4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein kinase, putative</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_240640</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699405.1">
        <property type="nucleotide sequence ID" value="XM_010701103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRW4"/>
    <dbReference type="GeneID" id="22575473"/>
    <dbReference type="KEGG" id="lpan:LPMP_240640"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240012300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_240640"/>
    <dbReference type="eggNOG" id="KOG0660">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="31"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="439"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="511"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="861"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="912"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="983"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1125"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1165"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="439"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="545"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="914"/>
            <end position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN98698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1210" mass="127868" checksum="E4E0D2001C21655B" modified="2014-11-26" version="1">MLVSSLGSHFICRGESDLQSLEVGDSVPVSQRRELDLGEESVSQIAALSNQHENCTGEISSDGAVKQTAVSSVMDEVAVLNYLGPHPQIVRFLGSYTTSKNTSFFTMELMDSDVGRELREGNAALHEESVCAAIAYSVLLALEQMHSHAVAHRDVKPGNILLKRLTESEEWACIWLSNDDLGASLLTKSSSGSARHPTLCTRNAASYVKAALGDFSAAHSTRCTDDAAFADTRGTLHYKSPEQLMGKRHLLSENVAAVDLWGLGCTLYEMATGARPFPGSSELQVLMSMLDAMGSDIQSFPVSTRHATLFDEIPASPAFVNFLQRLLCLDPARRCTATEALRHPFVAPIRDSAEHQIPTDCRQRVIGIPLALKYASFTHIPELRFTRISQTPLKAMDSTPTGLSAPQQAVYSRRVVPPPASDAGAATLSVAAEREVIAPPRSEYRDTHPWGDGPATTAWGQEVDCEDHEEKETPSKKPPPPHCSDTTGTSFLSESSYLHWSEIRPIVRPSAPPQVYSLPKPLQHKDDKARSSSGSRAVAFFGNATVGSTPSPTISGNNPQQQLQSLSGSKHRTAAIETQNTVSRVLNISDSSVKGVRAERSASHVDFDLSPVPATQLFSTEADTSAFLVPHPAATFLPRRAHPTLQLPNGSTFTASNLRANLSFEHENLMVGWYGSNGAPTSAALGVASSTSAILAGHCSTPLQHRGRRSTAFSGRALCFSEEMDPFARRSWGSSAGQQSCLNSLLTSPAPVGRAVAEECSPQPSPICPVEVATRSPSGLPVVADRSGLSLDDSGVGLGWIGVPPAVAAVQASICGDASEAAAAATVPALVCDVSRGAEASAAVAPMFCSAHLQPSWNAGHPMASGSAQSSNSPWAHHLKSPPDGCPRSPACSTVASATAVASIAVADQPEAPCSSQLRRPTTSLPLTSARDVSSSRTLPLPIPLSVATVRQPVSPSLCTPTLRSRTPTNRALHETPLTQRFSCPTSTLRTGRTGHKNGHLWDSSKPLGPPTSCVNSGDTPIASSFLCHRDINVPATHLTHRGSMSVGLPGSGSGAAPALLGTAATSPDLLAVFTYSSQYHCTPSSRYPAPESALPTRGDGSHHPVAAIEASSMPTATVVRALEKESSTGGSHTPLPGHGSASPPSRRCDVPLLQLNPASLGRNLQSVKGHESECIETSQSKQRGSMKRAREEAMNSEDVAAVRQSARVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRW7</accession>
    <name>A0A088RRW7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tubulin--tyrosine ligase-like protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_204970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-glutamyl-[protein] + L-glutamate + ATP = gamma-L-glutamyl-L-glutamyl-[protein] + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60144"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:15517"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:143622"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:60145"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698696.1">
        <property type="nucleotide sequence ID" value="XM_010700394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRW7"/>
    <dbReference type="GeneID" id="22574709"/>
    <dbReference type="KEGG" id="lpan:LPMP_204970"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200056400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_204970"/>
    <dbReference type="eggNOG" id="KOG2156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106437">
        <property type="term" value="F:protein-glutamic acid ligase activity, initiating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070740">
        <property type="term" value="F:tubulin-glutamic acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241:SF145">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE TTLL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="90"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN97989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="748" mass="79883" checksum="7927470B7E3AD2A3" modified="2014-11-26" version="1">MSAGEADQHVVWNTVAPLPSLTHRCADGDVVAAARRARSALEPFLVSPSVVLDPSSTTTSTDESAGLTSTDVYLVDSPYKRRRPTIAFVPYDKPATGDERHHSDRGTEDESISMHIDVLVQPDRLPLGPADGRSGESGPAASSLDVAQSQRRVIPRASAGPYSRLSYIMDENCTPFTALLATLRVAGFTRVSGRAALLHKTHSLLWVKHLLPSMVNQALQPQTGAYRKVNHFPATHALGRKDKLCLLLRRAGLRWQASGNLSTALSDTCTRSAAATRAAVWASLTPESWLLPQEVEACVRAIRQPHPSAAASPLFIVKPTNLAGGQGIFLIRGSSEAGVMSLMAAVGGLGGSPSSTSRTEPVTGSLDSSAVGSTAVAATPAAETVRSNYIVQRYMANPFLLEGRKFDLRLYVVVTSYDPVRMYLYREGLVRIASLPYIRTTATAAAAVTTLADVSDLRAHLTNFTLNKGASLVMAGESDADAATAGTAANGSDTKWSLRSLEAYVASMGYDWPGTLQRIHELLRLVFLSVTPEVREALRASSASRLKSAASNTAASLPPLAAVSSHATTNGTSPFFEIFGVDVLLLTDDSEENFPHDLLAVSASACTLRPVLLEVNIMPSLSTHYSLFDQRIKANFIADALTLVGLMPPPPLPKVAFSTAGVQNTTGSQRSCYNDTFLDGLCDSDVLNVCLATEEEHRRADNFTRLLPTHNSASKYKALMEVAEENGTPTAAPSRLDTVLSSWLASSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSJ4</accession>
    <name>A0A088RSJ4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_252340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699804.1">
        <property type="nucleotide sequence ID" value="XM_010701502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSJ4"/>
    <dbReference type="GeneID" id="22575882"/>
    <dbReference type="KEGG" id="lpan:LPMP_252340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250025500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_252340"/>
    <dbReference type="eggNOG" id="ENOG502SMBG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272734at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="494"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="536" mass="58413" checksum="70FA50090365AB4F" modified="2014-11-26" version="1">MGSTNIMCDFFYVDAVSPHRQSNVRPAFAPLSQTWVKPELLENSTATFLDSILYTDCNGTAAAQMWLRVDQDHYRQLGAALSVSSLVAACRVPLVCPSRADVPIIGGAAVLVDGASSVAGQFHLIYPCVSSTDTSLREVVHSWNGVQLSVTRKRALLSVAGTTPPYAATVVVNEAATAGVFVLEWGAYHRADAFHVRTDAAVRQGLVAPVTVLQMRAPLMEGETTPQSLRHGCLTESLVGFIVHEPYRQRFIFSLASIPSTNAQVSCGEMQTVLEMSTATPYDADEALVPCCGLAQRLVYTDCALTRTHLHASPLLEVTQVALSVRVEGALSRPSPLSPMSNVTWQLCGSQRYEATVIRLQRPLEERPSWVVGPLRAVSSNQPCVGSTLDHAGSVATLARRCSDAESRSQMRRVTCAVEEHFSIFSRHEGYSVGGVSHRCSLTLSVGAIYSTYSYRPQRVGTMHESRSCRRMAATWWQSPPLWLSRTACRITNYSLFELSALYALIVIVCFFAHLLLRGSGRGDGRGVLFTRPAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RU54</accession>
    <name>A0A088RU54_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_241520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699491.1">
        <property type="nucleotide sequence ID" value="XM_010701189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RU54"/>
    <dbReference type="GeneID" id="22575561"/>
    <dbReference type="KEGG" id="lpan:LPMP_241520"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240019000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_241520"/>
    <dbReference type="eggNOG" id="ENOG502SMJU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267435at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="748"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="364"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="505"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="756"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="995" mass="105722" checksum="84B891AE82734F52" modified="2014-11-26" version="1">MYVKQRGAQKDGEPSVRLMDDVKRLAQLEQYLPAHIFGTVLPLVKEEIASSAVELNAQVDGTRQLLLQSAALRRSTVLAPLLKQLLVTRAIQLQRRRAQLVQQLQRQIRHWRSNPPGAGAIIASSGGGSYRRGGPLSGSAAAALAHADEGALRETWATLREAFRFEEARAHLVQAPLCPSAAALRALLAEVVAGGQRGLHRRVVEQVAGTSPHHSQRPTTASPSTKAAGDSTKGNREADVSGSGGSEGPEDAIEAALQLLLRYVRQAQAGVLGADRTPARGRAPQSGVSSPTPASSAPLTETTGLQPSAVHGRLQAADPIDVCDVDMYSNDLEEQAQDAEEDVFEKSQILQQQRAAAAVGEVPGSGTASPTAPTPSATGAASEQASMWLRVPGILPLGQYCAELPWVADLAAQRYTEACERKKHCSGGAGEVGYISRHLQPGEQGSGESVEGKEVRYEAGYIAPTPAALQMMPPLGYLFAPTLACSSVGSVCSGGESVVGRAMRHAAGGPADAPHAAPADFREEREGTTSAQEEERSWMARVVVKCVSAAVDAAWQDVEETVVAPFCAQRRRAFSSWSLSAETTLAAVPVGSSAGGGEAADEEEVITQFMEVLRVRYAVELAAQVLAARHATELLLDSEDSVIFAERRLVAVVVGGGSFSAGACSEGHDAVAAKRASPSPAPVLTCTVLSLPGVTEIFYVMAYCTGAALLSDVTAAISISGYDVGNRQGGADALQRQECLILDLDAEEDEEEDQLEERPLVEHDSRLTGDPRHIFSPSASQRADLANEEDPVAQRQASLQAWAAFFEDEYLRGCQSTTASADVPWSAGRASVYSSWSLAPYYRLWLYLWEYVLVVAAPTSSSTDALHSSGAAERDCFIAQCSHSSQRSSQHPRGQRQPYRHGGASLAQIPISLRTARRWMEKVIRASMMYGCTEAGLLVSCAPPASLVYEPETCLQTHLSVEQTERLMKATALQARRALLQVSGAGGAAVKSPPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUA7</accession>
    <name>A0A088RUA7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_242170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699556.1">
        <property type="nucleotide sequence ID" value="XM_010701254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUA7"/>
    <dbReference type="GeneID" id="22575626"/>
    <dbReference type="KEGG" id="lpan:LPMP_242170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240029000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_242170"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47936:SF1">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN GUN1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47936">
        <property type="entry name" value="PPR_LONG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="58"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="27351" checksum="3D49D962E551469B" modified="2014-11-26" version="1">MHPRTSGQGLFPRYGGGWMHQFGHVYALQQELLDPSANNWFRAVELWHTARQEGVAMNVSHFTSILRQCIQPGAWVQSLQVLEQMKRENIRPDVVGVGCALAACVEGMHYGEVEDIFAAFHKTMLLDSICHLALIRARQESGNAKAAIAAGRQQQAEQVPFLPYTYTHLLEACNAEDDSAYAMELVRNMHSEQWAPSQRAMLAIEDLGRRHKGLATVSRPLLSTSDKTEGALRSLDASKCLPRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUD5</accession>
    <name>A0A088RUD5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein kinase, putative</fullName>
            <ecNumber evidence="9">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_271400</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="9"/>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700227.1">
        <property type="nucleotide sequence ID" value="XM_010701925.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22576318"/>
    <dbReference type="KEGG" id="lpan:LPMP_271400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270021000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_271400"/>
    <dbReference type="eggNOG" id="KOG0198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275301at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06606">
        <property type="entry name" value="STKc_MAPKKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001263">
        <property type="entry name" value="Protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584:SF369">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="515"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="108"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="262"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="864"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="985"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1076"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1102"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1277"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1387"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="286"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="436"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="869"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="900"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="919"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="999"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1127"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1142"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1185"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1214"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1324"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1427"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="543"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN99520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1491" mass="157264" checksum="26E2509D9012F79B" modified="2014-11-26" version="1">MNSSPASTHTSAFPDADTTSIALSSAEFLECPRCHRHCKSRTWFLKHLEACSKSASSSSTRGNTVSGEGSTGTPRAVAFTTKSNHHYRHLSRSSATEDDTPLLLESMASTTTSSSTSHSHQQSHKPSRLTHVAGSDGREAGLSNSIDAGPSANAGFSRSSVVALGGYRDGRSESNHTPTATSQASPHWFIDDLLVTRSTTGVGAGGGIISNGMSRPTSPSQGSPIYVASPCGLRAGGSCSESGSAHVSAAFGSASAPAAAQASSSSYMRHRDEGQPHRQPARQESFRLQSDFTWTQYTPSASEEEKDDDALGEHDGSVLDYSIRRLSRNTGAEQLMGPGYADRAPDQWVHERLLSGGSNTYRTNSPGAVIDVSRHAATDMLHDATRPLQGEQQVPRIFSGSIAELSPLARNVSGVADGCQSVGSGTNSARFHRSAHSSASPVSHSRTSSCTSPVFSQAIGSLSFLRINVSPTSATPIGSSANQLNGLNASFSGGSGRTPRQGDRCSTVTPRTISFQRGRAVGSGGFGTVYQAILSDGSLAAVKELKLENANLKAIDREVRAMSSIPPHPNCVRYLGSRYSAHHYYIIMEYISGGSINSLRKSVGRFRESVFQRYAYMVLLGLSHLHANGIVHRDIKGANVLLDESGCAKIVDFGCSGNLNQATTTLGCGGTPLWMAPEVCRGEPATEKSDIWAYGCLCLEMTNDTGVPWNFLPGMTLQGVVYALACAKSPPPIPTDLSSEAQDFLRCCLRVDPEERATVAELLQHPFFDVDLMENSEEDELLSSCEVSARQSAVKRVVQQVNRSSALDAAAHVHEQQQYRNNDGEVGGSAGDAQGSPLLQGFAGVSLSSRGIYSGGCGPILEPDAGALSRSSNSHSKSPSGPQLDHYTRSVNIGFSLQPVDDDDDDTGDGAGELEDNAGPSPSLCGGPPSAIAETAVSANRCRTSFSYAGVEEDENEYKQMITEIITQAREAYTDEERRMTERQRRLNLMCRSSDEDTSITASASSGSDTNNSDVGNGSDSRSSAEENEMSQHGDIESDLSTLSSSDEDDGLNSHSVGGPRRHSLGATWRAQFTHPSAASEKAGEPQGAASTALQQEPVSVARGEDSMAPLVSASSSCRGRLPRPGTNSSATLAATSPTSARVDSTDTSISPYGAISSSTPGLEVSPQSQLSPHSAPTHPSLTSPYPPRKQQPRPSPLSPPMHLGEVMKRDFSRTASRSRISTPFSKSPSDSVVVTAAGGVASSPHETGGPAGLPTAVWQPVGTSPSSPHIFVGAENPLPLPSAPAAQHGTVGGPVLSDRSSSTRNLPLQPPLAVGGPHRQTTPPQPAPTTAPPSAHPDFAASSTEWYFGSSGRIDANSATWKTGASDHLSRELSMAQKEMQEMLDWGTSSDRRHALSSSSPDIGRRSSKASSTTVPSAVRGDNGHRSRCCFRHLRRSHGENADPESTPVTPDLSRHVSTGLSAMETVPAVQQPAKRKLCGLGIFRSMRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUG0</accession>
    <name>A0A088RUG0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ribosome biogenesis protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_250440</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699616.1">
        <property type="nucleotide sequence ID" value="XM_010701314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUG0"/>
    <dbReference type="GeneID" id="22575692"/>
    <dbReference type="KEGG" id="lpan:LPMP_250440"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250008800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_250440"/>
    <dbReference type="eggNOG" id="KOG0319">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5414888at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001656">
        <property type="entry name" value="WD_domain_-_G-beta_repeat /Utp13_specific_WD40_associated_domain_containing_protein_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001660">
        <property type="entry name" value="WD_domain_-_G-beta_repeat /Utp13_specific_WD40_associated_domain_containing_protein_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013934">
        <property type="entry name" value="Utp13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF15">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08625">
        <property type="entry name" value="Utp13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="256"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="557"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="600"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="664"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="708"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="750"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 13 C-terminal" evidence="9">
        <location>
            <begin position="849"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="108"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="997"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="998"/>
            <end position="1017"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN98909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1017" mass="110796" checksum="D782F4A58EF4F33E" modified="2014-11-26" version="1">MEGKNCFRTRWTQEPIFSGGALASLALPVPSPATSSTLFRSGAVEECLVMACGDTVNVVRTASGEVLCRYTLPVEDVILHIDAVTVHESAGDDNEDAAAAEDGFAQVKNNAGAANRSTTTSESSRKKVRAGKTAKLEEEDARHVMQAEKRGAVASARAPSRGASTSHDERELAAPPGSYVAVGTRSLQVYVLRVDSRVELPILPSLSLSAEHGAVAEAASEEGSAAEAEGAKGDVVRAETATEVLVQYSIKLERNWTAAQHAISVVHFSQSGVYLISGATDGTVKVWNVFHHHLTHNLVCAHNSLVQSVCLDPSEAYLAVGSFEGHVTVFDFVAKRMVAEGRPHVQAVESMTFNDALTHVYSIARDRRLALNKMMCSEGHKSTGLKEVRAIVVKEHVSSATFESAEMLHVGAMDGVVTTYRVSESEAIQVVRRLPKAPAADAEDSAEEAFVRSLLVAGKPKGTGMRWLHGFVVHDTLPASETSSLYVGDAGFNIQFLAPATAERSQYEVIRTIVGFLDQLLDVKLFPEASPLHRAVVTNSKDVRLYASDGCVSSKTLRGHSDVVLCCAVSSNGAWIATGAKDKEVRVWSSEGCETILRGVGGHAAEVTSLSFNGRQTDTYMLLFSVSSDENLRMWDVGVPLADRALAERPRSRVVEIKHRSGVNAAHTGPIYTVAVAPNDQYVATGGKDKSVNVWNITGKKIYREASLKGHRRGISSLAFSPVDRVLASASNDGSVRLWSLVSLTCLKAMQVDRTSVLQLSFFNNGTQIVTGNAEGVLRVWAIASSESVWSAEAHTEKIWALAVEERAALGETIFYSGAADGVLIATEDYTAEEVTRVKEDRHNMIQQEQALANALRKGEFSEAFMLALRLSHPRHLRQVLVRWCAKDARQCENALRGELLPALDAEQMTRLLQYTREWITNSRHCMVATLVLYTLISSRHFEAVAQVPSMSSLIEPLLAHTRKHSQRQHDLLRRTYYIDYVIRGLVPNVLTSLPPFVHHDDSQKEKPPLAKRVRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RV09</accession>
    <name>A0A088RV09_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_282300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700570.1">
        <property type="nucleotide sequence ID" value="XM_010702268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RV09"/>
    <dbReference type="GeneID" id="22576675"/>
    <dbReference type="KEGG" id="lpan:LPMP_282300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280029300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_282300"/>
    <dbReference type="eggNOG" id="ENOG502QPQ0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272077at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="CDD" id="cd06467">
        <property type="entry name" value="p23_NUDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001400">
        <property type="entry name" value="Mitochondrial import receptor subunit ATOM69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="7"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="136"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="503"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="137"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="503"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="515"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN99863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="651" mass="72097" checksum="06E4E1F231DB2E95" modified="2014-11-26" version="1">MSVPVTESIGKARWTQGEDDETCLEVRIPCVLPDGVRPRELTVDIKDSCILCISHKETRILQWRLYAPVNDEVEWRMEDDNILVVELDKRSGAPWSCLLDLQMRADDELLTSIAEIDRMFRTQLPVLPSIEGGEGEYAAKKASDQDEVEKNGEAGGKEAGGEDDLDKLLDEVAKEVTGKEPKENDDEDDSTAAFIKAELENYRVEEEEIKKKLVEVEATLNNSTDTDATNTASEQKNILSEMARLHNQCRAIRSQPSTLENFLMCTQLDLQKARVNIGETGENEEEEYQSDEERELSATELMTCGLKFFEDQDIKGCLHFLRLAAIHHKHEQSTLLLYNIYSQLQSPRGAFLLMKRALDDSVPSAAVNQKIGELYDQGARHFLPLFPAAIYFYQRAAKLGHVNGMLSLAQLWLRGSTASSMLSEEEVEAQQSISKYHAWLQKAMDRGCGSAYFVRGCMHIKGEHGMAKSYAAAKEYLDAAASAQPEILRRAPQIPMMLEMLREEEEKSAKPKEGTTSTSASTTKAAAAATASAAPTASAKTADEGVKVTSSVARLNALSSKADNSFGGSGVMAPRTVSEGAAMRVRKGFRGGSRSKFFWEQACVASVTMYSVYTLAFPIRIILLPFFYSAISGIIERIPWLANSNADLSMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RV95</accession>
    <name>A0A088RV95_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ER-to-Golgi transport protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_291270</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700735.1">
        <property type="nucleotide sequence ID" value="XM_010702433.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22576891"/>
    <dbReference type="KEGG" id="lpan:LPMP_291270"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290016900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_291270"/>
    <dbReference type="eggNOG" id="ENOG502RYN8">
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        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sec16_Sec23-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402">
        <property type="entry name" value="RGPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402:SF6">
        <property type="entry name" value="SECRETORY 16, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12931">
        <property type="entry name" value="TPR_Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec16 Sec23-binding" evidence="7">
        <location>
            <begin position="1534"/>
            <end position="1698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="169"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="346"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="431"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="555"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="673"/>
            <end position="737"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="753"/>
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    <feature type="region of interest" description="Disordered" evidence="6">
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    <feature type="region of interest" description="Disordered" evidence="6">
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    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1116"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="6">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="6">
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="6">
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="6">
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="32"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
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            <begin position="53"/>
            <end position="65"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="6">
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    <feature type="compositionally biased region" description="Pro residues" evidence="6">
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            <begin position="178"/>
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            <begin position="805"/>
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        </location>
    </feature>
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    </feature>
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        <location>
            <begin position="1308"/>
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    </feature>
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    </feature>
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        <location>
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        <location>
            <begin position="2201"/>
            <end position="2212"/>
        </location>
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            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005927"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
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            <dbReference type="Pfam" id="PF12931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO00078.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVK6</accession>
    <name>A0A088RVK6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_291080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700716.1">
        <property type="nucleotide sequence ID" value="XM_010702414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVK6"/>
    <dbReference type="GeneID" id="22576872"/>
    <dbReference type="KEGG" id="lpan:LPMP_291080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290014900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_291080"/>
    <dbReference type="eggNOG" id="ENOG502S32H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="242822at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039963">
        <property type="entry name" value="Unchar_22kDa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38828">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38828:SF2">
        <property type="entry name" value="MEIOSIS-SPECIFIC NUCLEAR STRUCTURAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="197" mass="23637" checksum="0F316183BCAF5313" modified="2014-11-26" version="1">MEAVEYSTLTAEQRLSPGEEENLVQRLYYRQMQLAAQREEERRATLERARAQTQKHISKEEEGHLVSRMYDQQVERFANSKAERDRKMEEEVHKNDKKMEPSEIDDQVRRMYEEERKKSRMRREALNSRYLLTAEPKKIGKKELKGCVDRLSHVDWEKRDEELFKKYVYPYDPKTTRISRDEEQAMADRLSTTKGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RW40</accession>
    <name>A0A088RW40_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">2-(3-amino-3-carboxypropyl)histidine synthase subunit 1</fullName>
            <ecNumber evidence="3 11">2.5.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_291780</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the DPH1/DPH2 family. DPH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="3 11"/>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00126.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700783.1">
        <property type="nucleotide sequence ID" value="XM_010702481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RW40"/>
    <dbReference type="GeneID" id="22576941"/>
    <dbReference type="KEGG" id="lpan:LPMP_291780"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000007600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_291780"/>
    <dbReference type="eggNOG" id="KOG2648">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1649088at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11850:FF:000002">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000002">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035435">
        <property type="entry name" value="DPH1/DPH2_euk_archaea"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF1">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004967">
        <property type="entry name" value="DPH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01121">
        <property type="entry name" value="Diphthamide_biosynthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIO00126.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="373" mass="41729" checksum="2817D638205848EA" modified="2026-01-28" version="2">MESLADVQHDQRQQREAQRKLGLPTNYRFEIDKCIKRIKEKNARRVALQFPEGLLMFSIPIADILEEATGSEMVILGDVTYGACCVDDFSAAALGCDFLIHYGHSCLISIKDCIVANMMYVFVEIDIDVQHFIDTVKALMPADARVACIGTVQFISSMRAGLRVLQEEHFIHPVVIPQNRPLSTGEVLGCTSPKVNPAEVDSVLYVGDGRFHVESFLIAHPGLSALQYDPYKKTLSQETYATAEMRALRREAVEKAKVAQSFAIVMGTLGRQGHPRVVDRIIALAQRHGKRVTLLLMSEIFPQKMALLEDVDCYIQVACPRLSIDWGYAFDRPLLSPYEAEVALGNAQWGEEYPMDHYSRAGGNWAVYTDKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWA4</accession>
    <name>A0A088RWA4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome biogenesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_300640</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in ribosomal large subunit assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RRS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701099.1">
        <property type="nucleotide sequence ID" value="XM_010702797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWA4"/>
    <dbReference type="GeneID" id="22577118"/>
    <dbReference type="KEGG" id="lpan:LPMP_300640"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300011700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_300640"/>
    <dbReference type="eggNOG" id="KOG1765">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28455at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007023">
        <property type="entry name" value="Ribosom_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04939">
        <property type="entry name" value="RRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="161"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO00299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="216" mass="25027" checksum="2E6FBE2CF416FDBD" modified="2014-11-26" version="1">MSEYQLDVGLLTVTDVSTVSGPMRREEDLISSCTNALKALLGEFVHLPTEVKKTKYESATTLVQLPQPVMQLPREKALPKPKPLTAWQKFAVKKGIDIHRKKSNRVFDEDRQEWKDKWGKRAREDRDKYDWLREVKSGYMPAEDGGDPFLDDLRTKHARLEKQKKKEEHNKRRSVHLMQAQEEVKHLSAASRNLSTASNGKFEKAKKFKKNTKRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWM5</accession>
    <name>A0A088RWM5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_302160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701239.1">
        <property type="nucleotide sequence ID" value="XM_010702937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWM5"/>
    <dbReference type="GeneID" id="22577269"/>
    <dbReference type="KEGG" id="lpan:LPMP_302160"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300025900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_302160"/>
    <dbReference type="eggNOG" id="ENOG502SEV0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041367">
        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="5">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO00439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="169" mass="18190" checksum="01B1884551E78151" modified="2014-11-26" version="1">MQISRIPSYEEASMAGADYTLSPMSPLAHLSKKIDVTKLKTKACRYFVLGVTCPFGDSCAFSHSEPVSPAAYAPGRMSAKSPVSLNFEDLSKSGSGHLSDTQSNDAAGEVTERVVFGQPPPAYEIALRESETLAAASAAAEELSTPPAYPKRFRFDPYSVNWIAYEKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWR3</accession>
    <name>A0A088RWR3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Intergrin alpha chain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_310110</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701403.1">
        <property type="nucleotide sequence ID" value="XM_010703101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWR3"/>
    <dbReference type="GeneID" id="22577437"/>
    <dbReference type="KEGG" id="lpan:LPMP_310110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310006100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_310110"/>
    <dbReference type="eggNOG" id="ENOG502QRZ6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="200924at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056376">
        <property type="entry name" value="DEX1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045232">
        <property type="entry name" value="FAM234"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21419">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21419:SF23">
        <property type="entry name" value="PROTEIN DEFECTIVE IN EXINE FORMATION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23722">
        <property type="entry name" value="Beta-sand_DEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839099" evidence="7">
        <location>
            <begin position="21"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="746"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="domain" description="DEX1 C-terminal" evidence="8">
        <location>
            <begin position="649"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIO00603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="785" mass="85763" checksum="3F79B5C95A95CCBB" modified="2014-11-26" version="1">MIAPFSLVLCALLFIAVGRAQYAEQLTPNSTSQCYSGLNLGWSARVGSSVYATPRIVDLAHDGHKEVLIPTFSQFLEALDGPTGEDIPGFPFMHPRMKTYASPLPVDLNGDGQVDWLVALYTGELVIFGSNGKVQGYLQVPPLTMKRNWVRDNLPPQQAANIRPGTPIQNGTVLEDILRARHMDDLTITPDEVLQQRSRHSLTRRRHTPTGAADMDDENYDALAKVSEQDVIEDKPNPLFDADELDIDEEMGPPWVKSEMDVGPNSHLSPEARASLDLLFHPELYRTSNLATGSEETMFEGRNLRRTADIILSEDEIKVDAHILATPVVTDVDQNGDLDVILHVSYFFSNDVINKHPERFPDGVDPHDFVATAVVCLNLVTGETRWAHLLHASTKNSSNAAYALSTPLIINADEDRSMEVYVSTSPGFVFGFTADGKPLGGWPVLLGPLSASPTAEDVTGDGTLDICIGDTEGKVRCYNASGTIMWEKDVIGGVADRLTFGDVDGDGVVDVVFGTTSGLIYALRGTDGTVLPSFPIVTGGSIVAPVLLLNLNGMMFGEGLDIVVPSHNGRVYLVRASSGCVQTIDIDEKSSSMVLADDVLGNGQMDLVVTTINGGVYVFETATPYTAMNAWPSKTKGVNGCSASGNHVGIAISPNFRTFRDIRGDTFNVEFTIYDARPVIMNRSYAVDITVGTRIRLYRMRFDKPGTHNVKVRAPLERMYSSLNVVLTLPNGQSFTDSISLSFNMYFMHAIKYTLIVPFLVVSAALMLVHKRHEVVEPEAVQYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RX64</accession>
    <name>A0A088RX64_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Aquaglyceroporin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">AQP1</name>
        <name evidence="9" type="ORF">LPMP_310020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701394.1">
        <property type="nucleotide sequence ID" value="XM_010703092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RX64"/>
    <dbReference type="GeneID" id="22577428"/>
    <dbReference type="KEGG" id="lpan:LPMP_310020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310005100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_310020"/>
    <dbReference type="eggNOG" id="KOG0224">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF9">
        <property type="entry name" value="AQUAPORIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIO00594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="285" mass="31393" checksum="4BF10ADAE295575C" modified="2014-11-26" version="1">MAIENHMDEDQQQRQKRDLTAQDTWPLYRYRWWIREYVAEFFGSFFLLSFGIGVTATTTFHAGNTASFQTNVSYLAITLGWGFGLAIALFITMGVSGGHLNPAVTLANCAFGAFPWRKAPGFMLAQLLGAILGAANVYGLFKQHFDDAAVMLLPNETMASKFSGVFVTYPNVSNVFAVWSEIFNTMVLMMGILAINDNRMTPADGYKPVAVGLLLFVIGITTGINSGYALNPTRDLGPRIFTAMLWGKEPFILHGYYFWIPIVGPIAGALLGMFLYVFCIIPSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RX90</accession>
    <name>A0A088RX90_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_310220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701414.1">
        <property type="nucleotide sequence ID" value="XM_010703112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RX90"/>
    <dbReference type="GeneID" id="22577448"/>
    <dbReference type="KEGG" id="lpan:LPMP_310220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310007200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_310220"/>
    <dbReference type="eggNOG" id="ENOG502SA1W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273328at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="206" mass="22815" checksum="B3EC67D1A8A02208" modified="2014-11-26" version="1">MEPSSTDDQEVHLTEVRVERGKQLGISNDEEDEEERPNDATASDTNAASTAASDTEQDRADDEDAADEEREEADDEEDEEDDDADDSDEDEEETPVYSLPPLPPVHTPARVQGIATAEVYGIVKELRRQMDDPVERAHAKAMLQGDTDVLLAVAQVLQEAHLLRRSKVNDHGDIEEELVPQPAAARPSLPTGYNSWIVETPAHPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXH6</accession>
    <name>A0A088RXH6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_310860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFAP97 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701474.1">
        <property type="nucleotide sequence ID" value="XM_010703172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXH6"/>
    <dbReference type="GeneID" id="22577512"/>
    <dbReference type="KEGG" id="lpan:LPMP_310860"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000011600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_310860"/>
    <dbReference type="eggNOG" id="ENOG502S7PQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2163395at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038791">
        <property type="entry name" value="Cfap97/Hemingway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029488">
        <property type="entry name" value="Hmw/CFAP97"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23035">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 97-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23035:SF2">
        <property type="entry name" value="KIAA1430 HOMOLOGUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13879">
        <property type="entry name" value="Hmw_CFAP97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="158" mass="18678" checksum="427A71A274C2AC18" modified="2014-11-26" version="1">MEPKRTGNMACVERERERNYGRHVERVRTQRSRIDNATPKSCAYVRPLGSMRGNVARAEQVNRDNQKLVEKMVYIMNTRGGVDTSEPWCDHNRAISSQRRRNQEQAVIARENAKILERLECAKPTYRADKFEADRRRNEEFAARASRYPYHPMDRTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXR2</accession>
    <name>A0A088RXR2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LPMP_311130</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701501.1">
        <property type="nucleotide sequence ID" value="XM_010703199.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22577539"/>
    <dbReference type="KEGG" id="lpan:LPMP_311130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310018100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_311130"/>
    <dbReference type="eggNOG" id="ENOG502QUFK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2684236at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070530">
        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071947">
        <property type="term" value="P:protein deubiquitination involved in ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022099">
        <property type="entry name" value="DUF3638"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022105">
        <property type="entry name" value="DUF3645"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051346">
        <property type="entry name" value="OTU_Deubiquitinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367">
        <property type="entry name" value="UBIQUITIN THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367:SF28">
        <property type="entry name" value="UBIQUITIN THIOESTERASE ZRANB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12340">
        <property type="entry name" value="DUF3638"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12359">
        <property type="entry name" value="DUF3645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13905">
        <property type="entry name" value="Thioredoxin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="12">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="13">
        <location>
            <begin position="4813"/>
            <end position="4838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1415"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1692"/>
            <end position="1727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="4320"/>
            <end position="4347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="4362"/>
            <end position="4384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1426"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1716"/>
            <end position="1727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="4320"/>
            <end position="4343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="4364"/>
            <end position="4374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="4375"/>
            <end position="4384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIO00701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="4961" mass="550722" checksum="DB05243E962294D8" modified="2014-11-26" version="1">[encoded data, 4961 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RY05</accession>
    <name>A0A088RY05_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NUDIX hydrolase dihydroneopterin triphosphate pyrophosphohydrolase/hydrolase, putative</fullName>
            <ecNumber evidence="3">3.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_321630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701848.1">
        <property type="nucleotide sequence ID" value="XM_010703546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RY05"/>
    <dbReference type="GeneID" id="22577904"/>
    <dbReference type="KEGG" id="lpan:LPMP_321630"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320021900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_321630"/>
    <dbReference type="eggNOG" id="ENOG502S64B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="447842at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="28"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="232" mass="25842" checksum="7732674F823B20DB" modified="2014-11-26" version="1">MRKLVNEQTHLGKVESKIVIIRGKDGCAYRRSIQVFFMNESAEFLLCQPVGECNDKFLQTVQGGSEGEESPQETARRETWEEIGLNLEKDATFICEVRPPAAAMGEEGQAGETRNEANEIVSEHRSAFRYKSKTWAKQGIRGQELYPLLYFLGREKMQHINTHGWERGIRAEFRSVKWGMLAELVEKAPPSKKAVMKSVCSAVAAAAKSFVESCSSSTAGLPNVISEEPLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYR4</accession>
    <name>A0A088RYR4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="16">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">LPMP_302220</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 16">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="16"/>
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        <property type="protein sequence ID" value="AIO00445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701245.1">
        <property type="nucleotide sequence ID" value="XM_010702943.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A088RYR4"/>
    <dbReference type="GeneID" id="22577275"/>
    <dbReference type="KEGG" id="lpan:LPMP_302220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300026500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_302220"/>
    <dbReference type="eggNOG" id="KOG0206">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="2"/>
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    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
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    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
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    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
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    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
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    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
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    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
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    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
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    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF19">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 16" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1115"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1156"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="18">
        <location>
            <begin position="12"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="17">
        <location>
            <begin position="106"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="19">
        <location>
            <begin position="935"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="13">
        <location>
            <position position="421"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
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        <location>
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        <ligand>
            <name>ATP</name>
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        </ligand>
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        </ligand>
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        <location>
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        <location>
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    <sequence length="1244" mass="137320" checksum="22BA3A3A1D1EA593" modified="2014-11-26" version="1">MRHIRPLDEAVANQYCTNLVVNSRYTIQNFLFKNLYEQFRRPLNFYFLLVAMLQFIAVIAPVNPLSTLLPLLFAFTLTAVKEGYDDVKRHWQDHTYNHTHRMVLDAKNSAWVSHINAEIRVGDVLLLRENEEVPCDVIVLGATSAVYIRTDNLDGEIDLKSKEMVQWSTIDPGSHSRRTYSVCEIPSQTEPPPALSIVAAVSDLCLVCPPPSSIIDFFEGRADLPPKPQGTVSDAGTAAVQVPLTHHHLLPQSCVLKNVAQAVCVAVYTGDDTKCGMNKGEAPVKWAQIDKDVSRYSVYIFVCQILNAVIFGFIGFQANRSAHETAWYLPLPANEASASALIYPLRFFLLTTVMIPVSFKFVVDVCKYYMASAVEWDVAMMHATATTAAWQLPESSACIGCKARNSNILEDLGQIDYVLSDKTGTLTQNMMELDSVTICPGHHLSVSNISGTWTTLPEELKKHNPTTLAAVQQFAQMVALCNTVEVVHPHASAGESASVSEIAYHAASPDEVALCLGMRKLGVSLVYRDEYRVVLRMHRGQDGSHYDCGVQVAAKDGEEEGERTWAVHHIFHFSSEKKTMGIVVEESDSGRIWFVVKGADDRVMAMASPAPSSSIASVHSTSSPLHPECAAKLSLYAHRGLRTLLVACRELTRDELTVFLRNVAEAGCLVEGRQAHLDSLRAQMESGVTIIGITAIEDKLQDNVQETIGDMLVAGIKVWMLTGDKMETAEQIGLSCGLYRASDMIIRIGERASEVANTSNWRQNLFAFPIEQLPQSSAAAALVSEPAAQMCGNALEARVLCFDASDSSQLSNEPLRLMAHTAGGIADGTASSTGGGIFVSGAAERSAVLVMEGGTVLDTILRDPRLRARFCELSSRCRSVICARTTPSQKAALTKLVREGGYLTLSVGDGGNDVAMLQEAHVGVGISGKEGQQAARAADFSITQFSDLRTLLFVHGQQAYIRTAYVIKYSFYKSMLISFIQLAYNAIGTHMSGGTFWDSFSLTMWNGFYTLPQTILYCLDRCAPRVVLERNPYLYKMTRHAVDICPSNFFGSFVFRGVLQSIGLLWLSTRLYGPDFAYADCGGTASNDVTFSVAYTALMLSQLYTMWWESHAVTPLNLLVLVGMPLFYVYSTMMYSDNPTLQYFGVFRKLLDTTGVLSALGISIALVVPSIIYFTVLAFLQPNPRDVLRRAEDRRQRLLLKRRDYKRMQPCWVRWFGATPEESSIFCRRGDTAPHMYSEGDLMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZK8</accession>
    <name>A0A088RZK8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SKP1 component dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_331030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702196.1">
        <property type="nucleotide sequence ID" value="XM_010703894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZK8"/>
    <dbReference type="GeneID" id="22578256"/>
    <dbReference type="KEGG" id="lpan:LPMP_331030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330015200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_331030"/>
    <dbReference type="eggNOG" id="ENOG502S9CA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2342932at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016072">
        <property type="entry name" value="Skp1_comp_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01466">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SKP1 component dimerisation" evidence="2">
        <location>
            <begin position="144"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="193" mass="21822" checksum="9401D7A1074FB61C" modified="2014-11-26" version="1">MTGSVEASPTSNPSPRFCADCVYPSDSTPTRQPVPPAQTVYSSSRPSPPSVPPLPEVEVPFPYFTGDILERVCRHMSYRFRMSSFGTEDGCYRVYAIKTRIIPRPMTLPLVEYLDMKDRAFIADWDEFITVQMVKAATLLNYEELLQLASAKLASYLIDRDLEEVRMLLGVKGDFKPAEDAELKKERAVDCLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S036</accession>
    <name>A0A088S036_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_320220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO00910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701710.1">
        <property type="nucleotide sequence ID" value="XM_010703408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S036"/>
    <dbReference type="GeneID" id="22577763"/>
    <dbReference type="KEGG" id="lpan:LPMP_320220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320007000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_320220"/>
    <dbReference type="eggNOG" id="ENOG502R738">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="278093at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO00910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="770" mass="81759" checksum="A322BA21F4C905D7" modified="2014-11-26" version="1">MSLYAVSISLGASSSYVAVAPVSSTTGTAVVPDTAPIKVIANSSGHRNTPVVAALMEQELLFGDNALHQYSRQPQKVVPYLFAYAAAAASIADAQHLREAEADDTTEPEVVTSDLLQVIEAASKQKYQGHCRLTQAASGKRRLGFEYTSGSDGDPVTSFISAEDLFIGFLNHIKEHSVDGVCGLTTTTGSGDAASSTTRLFLTLVVPRYALPGTAGCAHVDHRGRTVEWLKEAVQSSHLSSVVLSTSVVFSDEAVVAAYDAATEERRVPRLLSTAPHNMLVVDWGAHSLCLSLLCSRGGTLVCPPRHHSVPYRCFTKGSSAVGEGYFAVGTCSGGDALDVALAERVAAQYMTQQRRLFASPSRNFSALLRLNHTLPTIGSTEHPATQLLHEVIPPRSMRRLALLIAEKKVSLNTNPQATSVAVEAEAFYEGMDLMDTQTMTKNKLENAIRSEWGLVDMFNNALQAFSEKYKDTWAEGSVDTVLLAGGMCQMASLTKVLAASIQSPGQRSLFAAGVRVLDSSLMGNGVCADELPSVGGCQQSCLVAESYRRKRSALSQQSRKGAGKLQAAVAAQVAETATSVWEALTKDSDDDDSSGEEAIQGEFMNDPHSGLFLARNVYLYVGDAAALTSAATQQLPYASLRVLLAHSAALPCRVALPWSPGSTEARVVLYLFTDAHDTPSTVPAGDLVEVRPVNCSGVVLSAATAVARDGTLSPLCLIVTAQAKWNEVSERVVQVSMQLVRVPSVSGTNIASLVLTPAIVCSTSEFVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S062</accession>
    <name>A0A088S062_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_341410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702568.1">
        <property type="nucleotide sequence ID" value="XM_010704266.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22578646"/>
    <dbReference type="KEGG" id="lpan:LPMP_341410"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340020100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_341410"/>
    <dbReference type="eggNOG" id="ENOG502SHCM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265671at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO01768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1875" mass="203218" checksum="0D9CF04D8D6C40B3" modified="2014-11-26" version="1">MEALVHNCPATDDGEDALLTWTREWLAFDRTTDPCATLVLSGEVSAPHPRRMGSALADVLVVLYIYVVRHGGRIRGGSPVAATNAMGARTTLGDSTVASLCTLGRGSDEAQWIVLVDLVQFLFSCWELLLMVVPTPSSKRAPASHTCMAIPSSYEKSPQCHTGVADYSQASSLLSPMLLGETGDDVPDKEEAVQLAKSHENVAQVTLESVHDVVRRVIREMFCVADDDAAAIEAGHNSGVLRSHAAIVMFLKLLQASPLLRRLVGSSPLLIRSIARYLLPRLVSLRHRQQQQQQQGHHHASGGLRGRSEVAATAIEALLSTLYIVSSSTALSIPLWPTQPLSAVASQLSCYCCLSDREVAPASALADRDGATLLETLCAVLQSCCGAHLSPLRLQALRLLHLLSSSPTTRRALFSSCCHGEVSTTYSMLEEQPGPTDAAAAAAVVFGSQRPSALDVAPHLLPLLLSSEDEEESVQLTCSVLQLILLHVQSPCHSLRSSGPCSDTVHTTNATPAGFTAAFTEGGFVGAADEVSGIKVAVHLASHIKDYTMQALYSCTNKTGYALVGLLDHAASVVAGARALLLGANVEAGPSVLHDDATVRWEQQQDWRVIFHVAEVDIALFEVLLKGSALHDALVPHNSANVSDDSSGARLDWDEVASSIFTVASQEHGAQLSLYTFLRCLDALAAGMRGNIQALWSNRLCELVHIVLKRVDGQVQDAKWRPADTADAMRTFSALVISGAPHGNFNDETPSTTAAPHARDAVDRPLLRRMLDSQTLHLLTRVTAAYLTASCDILLPLGVQLLMDVTHTGRLIAMHCPEPSGYPTMLSTSVEESRCLLRIATLLTRTQLESWTTSERTFESKEGHMRYASNGVSPAGQNITMSLYSRPGRPHIPQYTSRSSGSANGDEDRVRLMDVLLGLYPEAPELLEARTTLIHVLARRDSAAHAQPEFLAAHASAFIGAASLTEVAMSPSGLQASLLLSLATLGCCPCVGRQELCVMLEDRCRSLCSHLQRTASSESTRGPAALWSTKAVAEGDAVDSAVVGTASDSDDTDDMGRLLDALQEMFRLLVVSTLWYGGTVSNPSRLWPALSSQAPAAASAADHIFSEAHAQALMTFVEDDVGLREGLCQFLFDLHTQYRVDVTGFLTFLQSEEHHAPRQRPQQAQAPSSVLFAAAVLSATLYDGDEPRNSTRMTGVTSPLRTYTHALRSVHWLANTSSQQASVPLSVELLLRSVFRVAQRELLFLNRGHHPQDQRTDLAPAVTTASPAAIASLQFVCNELAFQQHGLQSGALPVQRAIVELAARKDAQRSAPDSAPGVALSIYVLREHLLPLLLRTNSNTVVHRKDLSMSVAALEYSTVLLRLMSVALWPLAPATCTSLDAVLAEYAMSRARQLLALTTAELTHTDGAARKLLYPLLQLLYLLLMRAHKVDVVRRYGTDLLFFAFRARHAAIARANLIAFGGVERGDLTDSDEDDVHVCVIASIVYIMAQQIADTRRKGAIRGIGVGSSGGAGAVGGGGLVPPSLKDMPWYVWIPIFRYYRCLQTAVSRTANDHAAREQQRSMVWTVVSGVEYVIRLCGVSHLVCCSHGAASAQLMETVPQVGQGGRNAPHAGEGHNRDERQAATILISWCAELILTPWMSSEDFNNTHLNVTVVSARLLYLLFYRFRALAATSVWFNPLVLSCMRQTTPSRFLQLPLVAEGWLLAALMQVLPSVQYWYAYDDYVKGSTMRFFEKPEIVARVTLVPCPPPREPPAHATAVPYIAVLEAAATASAVRRVGACGGWADLSTAEPELSCVLRILVTACRQYELSPERLHSRRRLEVIIPLGLQFVAELPVRESSSLLEYTFPYTIPFTRAGTPPLLLVFRCFTDQLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0F0</accession>
    <name>A0A088S0F0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell cycle sequence binding phosphoprotein (RBP33), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_340880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702514.1">
        <property type="nucleotide sequence ID" value="XM_010704212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0F0"/>
    <dbReference type="GeneID" id="22578592"/>
    <dbReference type="KEGG" id="lpan:LPMP_340880"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340014500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_340880"/>
    <dbReference type="eggNOG" id="KOG4679">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="243127at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047767">
        <property type="entry name" value="PSP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041131">
        <property type="entry name" value="RicT_YaaT_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830:SF16">
        <property type="entry name" value="PSP1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="2">
        <location>
            <begin position="281"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="408" mass="45008" checksum="BB2CE2839917E0FB" modified="2014-11-26" version="1">MAYTENRASKAIDVFLDSRSGSPSAAASASVTTSNNAMDHNRFATMIALQNRLLSIMAEAQTIVQHLQQNGFFPRGSGANPEEDAANIIMQMLRASLEVSHSSATSPSGMVCGSPSTMDAGSMQHMSSLNSNIPAALDDVPSRAPTKSSPHNNSNSRSSTDNVAHNAVSHNVVEEFLLSGQDGQQQQHYSNTANANHNEEGDELPEGSEMLAFVEFKRGRVRKYVCEHRIEPGNYVLVDGDRGTDCGLLVQTIERKPNNETAVVSMEGCDIRDDKIKLENGRVLRQASEEDIDRLHNIIANAESVALKTCRQRCLELGIDIDLQDVEYQFDMKKISFFFDCDHSVDFRSLVRELYRTFGARIWMENINPKVKNSMPDASGHERSHGGGHHGNGGGWRNNHRGGRTRDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S137</accession>
    <name>A0A088S137_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-damage inducible protein DDI1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_010610</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DDI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009370">
        <property type="protein sequence ID" value="AIN95161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696703.1">
        <property type="nucleotide sequence ID" value="XM_010698401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S137"/>
    <dbReference type="GeneID" id="22571790"/>
    <dbReference type="KEGG" id="lpan:LPMP_010610"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_010005200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_010610"/>
    <dbReference type="eggNOG" id="KOG0012">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1047367at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05479">
        <property type="entry name" value="RP_DDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019103">
        <property type="entry name" value="Peptidase_aspartic_DDI1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12917">
        <property type="entry name" value="ASPARTYL PROTEASE DDI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12917:SF1">
        <property type="entry name" value="AT13091P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09668">
        <property type="entry name" value="Asp_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="6">
        <location>
            <begin position="377"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN95161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="421" mass="45561" checksum="6132AB06590E6445" modified="2014-11-26" version="1">MVQLTINNSRGITLCRVSLPASATVQQLWEHLIAANPKLGRVQTIRNEARQVTHHLPLGSSFTQSGISSTELTLLQAGLVGQDVKAETLVVLMAPRSTTSSLAAAVNNARERIVEMFDTATGSQPPPPPPPAVGRVVALPPANVDPHMMDGHQVAQQQRMYAQIQQQQIDENLANALEYTPEAFAGVSMLYVPCVINKVPLKAFVDSGAQNSIMNKRTAEQCGLMRLVDVRMRGVAVGVGRQEICGRIHMATVNLAGMFIPFAFYVIEDQTMDLIIGLDQLRRHQMIIDLKHNSLIIDSVKVSFLPERDLPTMPYDDELASAPAKADHQAHGPRRQNPSLTTAKTITTTTASAPAGATLRAEAAPAASALAEAPVLSENERLARIQELMTLSGITDRKQAVELLEAADWDTIVAAALLFDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1B9</accession>
    <name>A0A088S1B9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_330620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702155.1">
        <property type="nucleotide sequence ID" value="XM_010703853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1B9"/>
    <dbReference type="GeneID" id="22578215"/>
    <dbReference type="KEGG" id="lpan:LPMP_330620"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330010900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_330620"/>
    <dbReference type="eggNOG" id="ENOG502SHWM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265384at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="650"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="666"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="676" mass="70714" checksum="0EDAEC1B056C62F7" modified="2014-11-26" version="1">MLNRVSDVLTPWTAPRILQIMEATSASRNTGGAASSGGLSTDGAADMESLLRLASQLPDVAGRVMAAPLFAQRPLVESYNSSVSLTTATPGVPSDGVSLTSITYEDARYMCTTALAVRRCAWRAESSNDDEPSTANVKACRSLPHTEPQIAAAELEEVGFAAEFSEPCICGSFPDAAAALRHVLPGADAGVSSESGGAPVQSASRRGAPDLFQGTLRSILRPPSVPRAPPLVKTASSPSSIHGGTSTTSHRLHLVQPSPSVASAKLQSLVLDTTPPPSLLPIEVRGPPGHRVFDGGCVAYSFSANEKEELLDSLCAELPPLRVFSRVEVEARCRPGGLNYDQASAPLSAAAGPATVTTGHVSRDGLPPSTDRGAPGSRVDNDDGWSTSTGWSSRSSSEPRRSTDNGKAKEKASKSMKRFDTVNDETRPESRAVAPDMNRPTSEVAPATHPPGTASTTRTWVNDDDDLVLENGHITIRKKKMRPVRDLSATRPLPTVVSGSLVNPSLMTTVVSAASADQRHFTSSATHGADYEVATGDDTAEDSAPHGKTCVAGAKRSRDSTAASAPADNQATARPLEPPQKMKSTGVATELKRSTAPAATSDEVSMASLPINTKSVVRLSQEEVLEFIESLRVSETLRRALLVGVAATSVAEGAPVNSPGTVSEVQSEKDGSLEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1H2</accession>
    <name>A0A088S1H2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peroxin-13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_344800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702899.1">
        <property type="nucleotide sequence ID" value="XM_010704597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1H2"/>
    <dbReference type="GeneID" id="22578985"/>
    <dbReference type="KEGG" id="lpan:LPMP_344800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340055800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_344800"/>
    <dbReference type="eggNOG" id="ENOG502S8H9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="250819at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="23692" checksum="4362212EF964760E" modified="2014-11-26" version="1">MNANAFNNGMGTGYGMGMDPYCMSGMYGGYGGLGMGGMYGGLGMMGMGGLGMYGMGMTPEAQRAQMMMFMTSRIMELWGMFSQVMQITLGSAVQFVGEYVGITQRMGQLEEENLNHEERYMSRKYELRKALSDIPREQRYMPRRTRIRKPKKLSFLRHFIFRLLRHVVIFAAAYFLSKRVTSLLMDRYGKKLLSASGPEALASSTASKTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1H7</accession>
    <name>A0A088S1H7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_344850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702904.1">
        <property type="nucleotide sequence ID" value="XM_010704602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1H7"/>
    <dbReference type="GeneID" id="22578990"/>
    <dbReference type="KEGG" id="lpan:LPMP_344850"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340056400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_344850"/>
    <dbReference type="eggNOG" id="ENOG502QT96">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272517at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="903" mass="98143" checksum="1FA68A43E2E78792" modified="2014-11-26" version="1">MPSEVDERLAAACVTGDEGLVEMNQEQLYALQQAFVQLCKDYVLMDTSGMKMSMLYSELNNGPDYELFDRKTRRRRHWLAIRRRYEDIRELLWPSDAAADGENASVASVGGSEPHQHSPPAAESLPVLPLADMMEALTWLEAASSFAIRKHRPFDTADAAEFRPLDLSREVRIVASCLRAAGSSSFLHRVAHGTAGQLSEDATHAMADRLISLGALCANHGVPLSVAFVSSTSTSCDAVTSSGSASVGSVQAWLSSIPVLSRVKDAVRVMGVMQTCMQDMDNIAAAELLRFSNADGAGVREALLDALCRVVPASLFSDAVALENVDEVDLCIMLRFCTEIQEQNAAFFQVTGGTERTPQSERAAAAEGRRVLQHFTQLVLTRCRRLLQSHNGSPVTLLSGDAENIPLVDLQSFADHNHPEVRVHHKIGRVNAQGLRHARLQSTASTTLAELLSRLESANQRMTSGAQKLRCDLLRHLAQKAALGKSKLTLEDVTRALPLLAELMHKTSEKQVKSTYDRLLTAMSITISVALQQPQKPACVLALLEGLARCHYTPSSYKLLEMVMLRMMMCGAFTLRETGRCLTAMLQVVGPKNVSQSLQQAIAMRVATAVGEKSDNTVADVLAVLRALRFSCYSSFASLTCFVSRSPLMESTVSWQPSERVRYAVLLAAAAVAPETATDSELAIGLATTAREQLLLGLSPTNPLSDVPSLSPACVEEDAYQECVAACAALQVRPTPSVLAAWAHAEVDLRRVHSLCTPKLAVSTMEALEAMGLAPSRWYSAYSDYLVDVLEQMQRGDDEGQRLPLLEDDAETTARCLYLQRAPESVTRLASALLEGEVDHLDRILTSGAVVPRGAGCSPVWTFQQRSLERQTAEDEAEARLLRYCTALQQASGEGLSTGSAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1J1</accession>
    <name>A0A088S1J1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_040190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="AIN95346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703668.1">
        <property type="nucleotide sequence ID" value="XM_010705366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1J1"/>
    <dbReference type="GeneID" id="22571978"/>
    <dbReference type="KEGG" id="lpan:LPMP_040190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040007700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_040190"/>
    <dbReference type="eggNOG" id="ENOG502SKPV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="257914at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35613">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35613:SF2">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839167" evidence="3">
        <location>
            <begin position="28"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN95346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="358" mass="40362" checksum="C1EFFF187CCA8EF5" modified="2014-11-26" version="1">MAPHAAAWTAATVVAVLLCYSATGVRGYDFVPITSLFYVPAATGTRFKDASMCLERGGYLATEATAVLHEADVQALESEGFTTYYAFLGGGIVQPWHMESYEAGFCPFALKDPDIWIDTPYSQTSGDNNNCYWRWSVGRWMEMPSKSSLPYDVEKTGIIFYRGQSTLGYDRQVNGFPLFFPFNPPMYHPNMQLGHHLVLYRGGQHTTEAVWGDTYARGGFTYGDNFADDPQLVAATLKDWKLVCQAQGPLRLNYETSSASTHLQERWWVIHFLILFVLCLITVLVVVLCQEREDMDEPPEDAPEWTEKEVGRRTVSHRYVSQRSFRTDVSSTASGNSLNEDSNFSKDEDDEGGQRVHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1W2</accession>
    <name>A0A088S1W2_LEIPA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_350820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703019.1">
        <property type="nucleotide sequence ID" value="XM_010704717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1W2"/>
    <dbReference type="GeneID" id="22579111"/>
    <dbReference type="KEGG" id="lpan:LPMP_350820"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350013900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_350820"/>
    <dbReference type="eggNOG" id="ENOG502SHCK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266112at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="559" mass="60554" checksum="E2688D1620E6BEEA" modified="2014-11-26" version="1">MQRENLPLALPFARQWTVPSTAGSDAGSTTLDYPSRHAESPSPLSQSQVPRTPSPGRARPRQPLKGSVTLGSPSPLPPLELSPFASRGAACCSDASLQLVSCPAPVGEFARNFGSTTVPEAVSDNGTDGESFWRHQAQRSEATCRALEEELIAVYRLLAKDAVGGFCTGVASSPASLIEFGSTSPLYETVLQERNMAQLELAREREKGFLLRYRLREMESEVHRLQRVHCRSVGRQRTGDASKRPLTSGNSAPHLEVASVQRRRSYSSCCSSSRSSTHSTHHARRSPTYPHSRSSTRPYTPSSARWEESPRPTCVPMSMSSTQRSDDSIVARSSAPPASLPTRREGGCRAATASVEAPAAFARPYGHGTNLPANSNRQVSHVYKAESRDLLTWVLSARPSSSASQCQPAAWRKGAAAPRNPGPVRHATFENPPRHVFHSDLFSAAAAISEEEGSSPLMRGPPWDAAETRRAMHHRRLRLPSPLPQTSDSNDNDQTRDHPSDTVSSFCAIPLMMPAARNSVDAAHGALSRKGVPTKPADHWKWVVWQPPASASHQQSGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S253</accession>
    <name>A0A088S253_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">H1 histone-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_333370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702425.1">
        <property type="nucleotide sequence ID" value="XM_010704123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S253"/>
    <dbReference type="GeneID" id="22578490"/>
    <dbReference type="KEGG" id="lpan:LPMP_333370"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330042100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_333370"/>
    <dbReference type="eggNOG" id="ENOG502ST38">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="137" mass="14598" checksum="7FA79E7DBE3F5A02" modified="2014-11-26" version="1">MFRFTLRNLARKAPAKAGSKIAATVSTATAAYHTAPAVAQTGVNIPPIPGVRSVRAFRSQKMAALQPQPVLPAGKKAAAPKDPKQVKAAVKPRSSKKTMAPEKTAVLVKELQAKKTKTPKIAAKVISKRAKVRKVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2A5</accession>
    <name>A0A088S2A5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_340220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702450.1">
        <property type="nucleotide sequence ID" value="XM_010704148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2A5"/>
    <dbReference type="GeneID" id="22578526"/>
    <dbReference type="KEGG" id="lpan:LPMP_340220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340007400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_340220"/>
    <dbReference type="eggNOG" id="KOG2988">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1928736at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000001">
        <property type="entry name" value="60S ribosomal protein L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039109">
        <property type="entry name" value="Ribosomal_eL30-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022991">
        <property type="entry name" value="Ribosomal_eL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002172">
        <property type="entry name" value="PRK01018.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449">
        <property type="entry name" value="RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00993">
        <property type="entry name" value="RIBOSOMAL_L30E_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="4">
        <location>
            <begin position="11"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO01650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="104" mass="11413" checksum="1152AA8038D16256" modified="2014-11-26" version="1">MAKKTKSKVDTINSKLQLVMKSGKYVLGTQQALTTLRQARSKLVVISNNCPPIRRAEIEYYCTLSKTPIHHYSGNNLDLGTACGKHFRTCVLSVTDVGDSDIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2D7</accession>
    <name>A0A088S2D7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_352440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703181.1">
        <property type="nucleotide sequence ID" value="XM_010704879.1"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350031000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_352440"/>
    <dbReference type="eggNOG" id="ENOG502RYHD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="278624at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="731"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="873"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="492"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="738"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="779"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="950" mass="102979" checksum="0B2C879590620993" modified="2014-11-26" version="1">MFSLNIKTEASPFSAAAAPAPEADASEAPLATIDVDEGDSFESTPSTNSSSGQGGRHRCQHVPRLPQTPPSPETPIKFDHGAYPHCPIFIPSKGRSDLDRSTMAVLVRDLVPFVLVVEREEVEGYSALLDRLVGLYFGFSDMTFASKVDDGTEGATKTEAEDVAPFHTAPADLWEFSCACCDGSPGVVGSPSSSTTPSLSADALRALALRLSAAFHHGYVFEPPTNVAAGGQDSIDESKNSSPPVSTSPTAPSAAGRGAWRPSEAFVLRNVNEVRALFMIEVLPESNRGVSYVRNYILQVLVPRLMVACGVDRSGNLEELCLYGPGEHNTLTPAALRMATLEPSVYSALETKSGTESYLDVRRASTITSPVTASTGSTAGTVDGGMASSVVGQSDPAGQTLAPALRSSTSSSTSAGTRGTPRILHGFFGFYWVLDDDIYGFYQSHGSSTKNERISARAMMREVEGRLRQLRRNADVASPPPPPVPPAGFQISPTPSSSSSATASPYFLSHQQQQQPFVFTCKEDALQNNFITGGKGRLPTLHNYNLYYTTACFSLEYNRFALDTAPDMLSVNSYNNIACLFNYALLHNPPQMRFFPSGVPHVRRPEEALVGYLDHSMLWYRFAVREDYDFTLQLIARGLYTLRFRSIAFDVPQMMKVRGGMTDYYRNCHEEIRQQNNRFVLQWSSVAQHWVKGKEGNRRDDIRVRWDLLSPARAKYPGAFLYLSTPLPQLQPQRLSDDGSSGNGSVASSSDSATTATNVEGSEAQARKRLRPPSPTPPTGESSPAPSGRRLDVAAAAASASVVSSTAARDWKGGYVVERWRDISHEEAWQHAGLVALSNDDIHIGRTVAVIPPFFDQKPSVVRATVIERAVEPTDSHASSGRVGNASTVERSDVKPPPPPRVVWTVVAQDVRGMPFLHVDTCFEVPAKGIEGAIASIDQFFAKMTEEFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2V9</accession>
    <name>A0A088S2V9_LEIPA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_354520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AIO02584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_010705082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2V9"/>
    <dbReference type="GeneID" id="22579480"/>
    <dbReference type="KEGG" id="lpan:LPMP_354520"/>
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    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_354520"/>
    <dbReference type="eggNOG" id="ENOG502S6CB">
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    </dbReference>
    <dbReference type="OrthoDB" id="252877at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="200" mass="22811" checksum="C631D7CE3FCCED8F" modified="2014-11-26" version="1">MRRAGLCTVARTTGAVGSAVVDQALLSPSPVSSLPHNYSGMSAQRRLRHSSGLFACSRIVRFDLRKHEMEKRRLRELERAGINPTDDEDAPWIAPEEQQRLDEAEEQRRAEREEQRQSFMKKRAEEDAVRRRKFKEFRAKQIAMSRHRKETMAEKKEETRQHRQQTSRVNFVEEVGAAEDDASVGVGSAPVKATSHSGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S355</accession>
    <name>A0A088S355_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_081030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="AIN95911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704233.1">
        <property type="nucleotide sequence ID" value="XM_010705931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S355"/>
    <dbReference type="GeneID" id="22572565"/>
    <dbReference type="KEGG" id="lpan:LPMP_081030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000013700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_081030"/>
    <dbReference type="eggNOG" id="ENOG502SAC4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273553at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="418"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="237"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="420"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="462"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="472"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="511" mass="54260" checksum="C8DA1E5A264A27F7" modified="2014-11-26" version="1">MWRAEENIFARARPARLDTQYSSTSACTTAPPARPLVPLQWFHVPGRGARDAQVPPEGLVASTHLSTSSLLPPRSLSLGHCGAADASAHELGWDGREVDGDHWGIAGSPTVAQQPLPPASHGGAGTRDTCSLGSLLRHPHVRPTHDTSADDTSPAEVSRLLRYYRDENARLREQLKAKELHEAHIMERLEETSRMYAHVQLAWQRATRSDPPSSVLQSADDNVGSVLSVGSGGGKAEEAMQSRLAQKEAEVRELRGRVEAYREALQRSRAHAACSAEERQAAPAPAACSTGNGATVSVPPTSLHVLLLQSLNTADYLVKVFNALQHCHYTRHRGASDSASGCCRRSLHDCRLRCLQAAMKGAPITPELLELEDGPENDTAAANMEAAVAVREELSYCEAVAVRLAASLLGRERFADDDAAPPVSATGAAAPAQKAAPPASPSALEVAGPVGVAQAAAAAPRDDDDGEESAGEGERNAEESGHSAVSCAVAVREPRRRPSRCRPDVGDCEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S380</accession>
    <name>A0A088S380_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pre-mRNA-splicing factor CWC22, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_355280</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC22 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703459.1">
        <property type="nucleotide sequence ID" value="XM_010705157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S380"/>
    <dbReference type="GeneID" id="22579556"/>
    <dbReference type="KEGG" id="lpan:LPMP_355280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350061300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_355280"/>
    <dbReference type="eggNOG" id="KOG2140">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1924287at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF3">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MI" evidence="7">
        <location>
            <begin position="358"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="306"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO02659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="565" mass="65250" checksum="6D60B7142BC8900E" modified="2014-11-26" version="1">MSLYVPPHRRQAAASSSEGLSSTCSVAFQQEAWRALSRSITGVVNKVSKDNLEQSAIELFRENLVRGRGLFARSIMRTQQIDSELTPVLAALVSRINKDLPIVVELLCKRLVVQWNRAYLRKDWRYVENASRYLGWLFLLRVVEVDVIYQLLLKHLMAEKRSDEDIDQAAKLFRETFRVMSLKERRSFHEQILIPFRDLLAMDDEEMRLSTRSQAVLESCLKEVQEWERRKEKEEPIPEHLVLFDLEVQQTHEVDLDEKYPTEDALDRYTFDPEYDTHEEQYEAVRKTILGEDWEMELLQQVADAEVDEDAEGSDHGADEGANNPSAEAGAAASGAASSPTSLELDASKTLIDSEERKLRREVYLAMRSSIRADEAVHKILRQMEPQTERTICFMVIEGCCEERAYRKMYSMAAERLCKSNSRFQAFFVEAFHARYESASGLTLKQIEYTCKVYSHLLRTGSVYWSRCLSCLDIVENNESQRLMIQYLFKGVAEEIGMPEVLERFQKDEELRWHTQRLFPLHQGVETLKAAVNLYVAMGLAEMTTPLRAALEEERAAHKRARVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3I3</accession>
    <name>A0A088S3I3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_355960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703526.1">
        <property type="nucleotide sequence ID" value="XM_010705224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3I3"/>
    <dbReference type="GeneID" id="22579624"/>
    <dbReference type="KEGG" id="lpan:LPMP_355960"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350068100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_355960"/>
    <dbReference type="eggNOG" id="ENOG502SJJT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273779at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="489" mass="55781" checksum="9DD0F77A8A42ED8C" modified="2014-11-26" version="1">MFSRSMQALLIRRPPFASFFKAVSVPLKTTKPPLRMKAAGILWRKTAPQYGSRFSAPRVAAALQVYRKEAPLINRQVRMTARPGRRSAAAASQRKLVRTTDTKLKAIRVKRRQQHKKRAATPFAAFRAEVMRRTKLPSTEASRKRVLRMWVMTGQQRSLSAPKRVEMAVRLLNKNRKHTKRLSRKMSRKIAKRRSKHADHRSAKRPARRSSHKLATSTKFRIASGKTKKGLRVRPSRKATALKLKSVPSKRGARRVPKKLASPKLHLARNAAAKPSASKKKAAGRSKVPKRRARKTFRATSRRSKLQRTVAKWRTSAARHRRNPYLRFYRYMRLTGLIPNHPKILGSRQIKALWAETHALKGLNRRIARATELLEKRTGLKSMVSPPSVRRPARKDQSSRRRVSLPSPSPAARKDLNLLTLKQSDIKVPRYYRRNPFGATYAALLPVLRDIPSSTRMSKVAKAWTHTSMKDDKRSAKARIAAVAEAMRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3Y3</accession>
    <name>A0A088S3Y3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_351630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703100.1">
        <property type="nucleotide sequence ID" value="XM_010704798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3Y3"/>
    <dbReference type="GeneID" id="22579192"/>
    <dbReference type="KEGG" id="lpan:LPMP_351630"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350022300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_351630"/>
    <dbReference type="eggNOG" id="ENOG502SE0D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268006at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="123" mass="12498" checksum="18824D74FFF89489" modified="2014-11-26" version="1">MPRKAAAATTKERSSSEESVSSVDSISSLPIIKEARTEDATVTAAQAPTCQLSPPATSAAMPGAAEEVVPLAALVAVNVDRNEEASFGLLKEPGAPSADVRRVTTEGEGAPAIPTDLLQLLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3Z7</accession>
    <name>A0A088S3Z7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_351830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703120.1">
        <property type="nucleotide sequence ID" value="XM_010704818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3Z7"/>
    <dbReference type="GeneID" id="22579212"/>
    <dbReference type="KEGG" id="lpan:LPMP_351830"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350024300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_351830"/>
    <dbReference type="eggNOG" id="KOG1124">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1926212at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45153">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45153:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="481"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="641"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="644"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="692"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO02320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="755" mass="83262" checksum="79A7C5663A64A5DB" modified="2014-11-26" version="1">MPAICFSSPFNGGTRGNPASSITAFKVREKHEAGMRLLQEGLVYEAIQLFQEASFFDVENVRPIVALAECYVFLCDLRSAIRCYWRTLWSLDKKEMDDYCCRANGIHTDTDDRVSAADNRRSDASNSPAGEWLKSGEETLFSALPDGSQETHEYDFEAAQKATPASFTAVEDHSPSDPSTPYVAGGIHSVERAACFSEPQRPLAKSVEAAAHAGPSLAPRSQAPRAELTVKDIRARLAGVLDALGLSLYRVGSVEQALRCTTEALELLDDAARAGEGGRNDMYVSKSSQLLTDPTISLHRGVYLMALQRDEEAEALLEAHFAVFLQWRPQAAALLVQLYCNRQAFRKARMLLEVQEKADSGNPDSSKAPTEVHGNLDEVLRSGRGDTVSPSPPSAAAPESLAVAKYLFTELYARYRTAAFASNNEASITRCLGIYPNDIDLLFRRAQLNLSAGKPKQSVKDLFRCVRETNGEHKEAMEAMTKVLFTIGLSLNGEAEMQDAVTYYSESLKWRPDNVLVLLARGDCYTKMESFEAALADYESVLCFAPGQRDARQRIASLHDLWGRKLFAQGQPEQAEAEFTNAIKTDGQNPQFYYHRALCRLKLDQGRYALRDVLSCKELHPCAPHLCAFIARYLELVQPPEASQRGNTSRTSARQVVAGPVRAALPPPHRGTRAAHTPPALRDRGGPPALQRMHDRNTDDTPFHSANGGPSTATSVLPRIKRQVPKQKRAELEGWVRGCRTTLHQRETGAPAPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S458</accession>
    <name>A0A088S458_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Small nuclear RNA-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_352580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703195.1">
        <property type="nucleotide sequence ID" value="XM_010704893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S458"/>
    <dbReference type="GeneID" id="22579287"/>
    <dbReference type="KEGG" id="lpan:LPMP_352580"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350032400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_352580"/>
    <dbReference type="eggNOG" id="ENOG502S8ZW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273103at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="350" mass="37864" checksum="5CA7C0C7FC5825F3" modified="2014-11-26" version="1">MPRETELERLTAFAKDYAQLYARFSNHFTIPERATIDGFAELFDASHIEYLHYCGGTTLDRPFFPAITSELLMLSSAYLSVPEAVAPRGTRTFGLLLSFFLYSTQPARQQPKALANARKEGSLSPLVPAGAPFTECTSPRSGERRATRIAMMTNSLTSSSTKQLQSCSPAKRTAATAPPSPPVPSSLRLPMQPVPISVSCMRLLLACLSIDAGSEVTSGQPSAATPPPSAAATVAPVSASPPQLSHTEAKVVLALHRATGWHIEPYLQQGKHVSALLSAHQACAVPLVQHITPVPRPLFAAILTARSMQYASAAPEEMGGSDSLFRDPDFVRLRQEYEAARRRLLLGERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S462</accession>
    <name>A0A088S462_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_352630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703200.1">
        <property type="nucleotide sequence ID" value="XM_010704898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S462"/>
    <dbReference type="GeneID" id="22579292"/>
    <dbReference type="KEGG" id="lpan:LPMP_352630"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350033400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_352630"/>
    <dbReference type="eggNOG" id="ENOG502RZBC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270695at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO02400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="373" mass="42492" checksum="A133D2CF386EFAF8" modified="2014-11-26" version="1">MSCDLNNPTVGAMTAAAAPKRMTLKEAIDLDGVPTTPSLKQRRLMDIHVTAYPGLINERMLPKHNTAVNDFSSIDPLQYRKAHTVHSNNVTSHSKKEENVLGMLTTNQFANRMTLLGMQLREERAKNPKDALTISKLAPRGYHSRFLAPSFDERSTYRWDYCQWEPDSFHDTVRRERLATYRDEWTENEKADVTMSMKVPYLTMAVSSEQLKDKATIYRKDFMEDATQAEYRSLSYKTNLGDLGTSYAYSAYSVDDPRRKICFDASIAAFKTPHSVLEKTFSPRSSFLEKSASAKQKSSAREELDHLRTMRREMTRLSAAKHTAAELTNSETATKPVVIPGIKGSGYRRAPKGNDSYVYLPRDHFSYQHVDNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S4M9</accession>
    <name>A0A088S4M9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Class 3 lipase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_130210</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697104.1">
        <property type="nucleotide sequence ID" value="XM_010698802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S4M9"/>
    <dbReference type="GeneID" id="22573131"/>
    <dbReference type="KEGG" id="lpan:LPMP_130210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290029700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_130210"/>
    <dbReference type="eggNOG" id="ENOG502RX99">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="438440at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000415">
        <property type="entry name" value="Putative class 3 lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47413">
        <property type="entry name" value="LIPASE-LIKE PAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47413:SF2">
        <property type="entry name" value="LIPASE-LIKE PAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="5">
        <location>
            <begin position="70"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN96451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="783" mass="85028" checksum="1F87434CB154174A" modified="2014-11-26" version="1">MRDFAYTHTQPQWGDVRTAAPGSTASAQRHTGIGSMAGVVEDVTIDTWAPTVVRPPPLEGHRVCTTCQRSKEACVCTTCIVCRHRFHANRHHCRRCWHAVCSRCWGHRHYVHMLGRQMVVCDCCSTLWALANLAKRGDGGLLWGLYVLRAAGAMPRMCIGPSCHILTRQLACYGCGLPTVVTQPHAARVVRANGVSRSMMDHVKVLDMQQLSLRAMEVSGMTSTQVERMFRGLFHHYEEVLAFRAITTAVLAHRVLLSMVASAVAYEYLGAPNITLSLSDIPYARALRITAARERYTILEAPGRVKFIAFPGTHNWRTRWVDMQFARITETVWSTLHEGVCLTTTAEDQEGVDRAKTTVALNGGVRKAWEYQVHKGFAQEAQEVELPFDSLLEDVRSGGYTLVLCGHSLGGATAQYLSLQLLHRCAALLVPRGGQEDAPRLLCVSLGAPLLGNYELADHVQSCGWAHIFHNFVYRSDIVPRLSCTDELAWDAQLRLANSVTSVFTAAQSWWRGGGSTTAPLPMANAAAAASSSTETVAANIPTRSSGRLSTALARLRTKPPPGTSSAAPAASAVDASAAFAFLSVDDATGSEGAAPAADDIFSNESSAFWAEQAQFAAYVDTAVRTGHDALENDVSAPSGDAAAQRDADVEAALHVFRSRCARTSGLSSEQLSFMHDVRHDSGDAGPDGDNQSVTPTEVKVAADTMEDVVLPVASRRMHRRFTCFGRYHFIQYGAYGYVSTDDSETAFGVLKHGCGEASVLGDHSIEAYNRGVMVHLYRNTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S572</accession>
    <name>A0A088S572_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_356920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703620.1">
        <property type="nucleotide sequence ID" value="XM_010705318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S572"/>
    <dbReference type="GeneID" id="22579720"/>
    <dbReference type="KEGG" id="lpan:LPMP_356920"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350079000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_356920"/>
    <dbReference type="eggNOG" id="ENOG502QTCI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269884at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="273" mass="32189" checksum="5DF1C1148EDE7076" modified="2014-11-26" version="1">MSSNPLISPSQSLAAHFPERTGGPAWTRQASANTTWTLQGLLLTDLWEEPLHTCSRTRDRLGYIDFGMVIPPIRAFVYSMLLPYASYPIALVHLYGFYRCTRTMVFPKYYKRQRYSERVMYGVQKRVYNARVRRILESQIDDVQEIQHALEVVGSTRNQFVDDPHHKGTAYFVVEQKIMKPEAIFTGENWAWAFISDTCRYVTPVLFAYLFHPSCKRLTVDWRLWRQGRLQWRQVRHPILNFFKTYNEYNLAMRRINITKPAPKGAQPWSRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S6M9</accession>
    <name>A0A088S6M9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc-finger protein ZPR1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_171380</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ZPR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697829.1">
        <property type="nucleotide sequence ID" value="XM_010699527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S6M9"/>
    <dbReference type="GeneID" id="22573881"/>
    <dbReference type="KEGG" id="lpan:LPMP_171380"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170020200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_171380"/>
    <dbReference type="eggNOG" id="KOG2703">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="308464at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000001">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000002">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1040:FF:000003">
        <property type="entry name" value="Zinc finger protein zpr1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1040">
        <property type="entry name" value="ZPR1, A/B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.420">
        <property type="entry name" value="ZPR1, zinc finger domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004457">
        <property type="entry name" value="Znf_ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040141">
        <property type="entry name" value="ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042451">
        <property type="entry name" value="ZPR1_A/B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056180">
        <property type="entry name" value="ZPR1_jr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042452">
        <property type="entry name" value="ZPR1_Znf1/2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00310">
        <property type="entry name" value="ZPR1_znf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22794">
        <property type="entry name" value="jr-ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03367">
        <property type="entry name" value="Zn_ribbon_ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00709">
        <property type="entry name" value="Zpr1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="6">
        <location>
            <begin position="49"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="6">
        <location>
            <begin position="266"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN97176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="466" mass="52428" checksum="B472477146596A17" modified="2014-11-26" version="1">MSERDHDEKSVTAEGPAAAQEGSDNDSNGEGEHANYIKTDLGEMNVIESMCPKCQETGTTRLMITKIPHFKEIIVSSFNCPHCDESNNEVTFGGTFGPRKVRYELQVKSKKDLDRQVVKSEFATVTVPELELEIPPESQKGSLTTVEGILEQTYYGLQLQQPLRKIQHPEVCEKIEAFCVKLESFRSGDVPFTLTLDDPAGNSYIEPLHDYYHPTLDQQLTKYETERTDIDRQLLGIPIDYNTERTQEEERDVAEGQFSDVTQIPCDCPACRKAGYLMMHECDIPYFKQTIIMAFKCDYCGYKSNEIKTGGEINAKGLRLTLHVKSEDDLKRDVLKSETATLIIPEVHLELSPGTLGGFFSSVEGTISQVRDQLNSLPQAAFAVGDSADDNSKTLLQFVKELDELLALKMEFTFILDDPLGNVYIQNPRAHLPPPDDADPKLESEEYIRTEEQDEELGISAMCRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S789</accession>
    <name>A0A088S789_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_190990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_010699792.1"/>
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    <dbReference type="GeneID" id="22574153"/>
    <dbReference type="KEGG" id="lpan:LPMP_190990"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190017200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190017700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_190990"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000669">
        <property type="entry name" value="SPRY domain/Ankyrin repeats (3 copies), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
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            <begin position="2145"/>
            <end position="2177"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
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        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
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        </location>
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        </location>
    </feature>
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        </location>
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    </feature>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
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        </location>
    </feature>
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            <end position="5627"/>
        </location>
    </feature>
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        <location>
            <begin position="5628"/>
            <end position="5637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN97441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="5726" mass="612324" checksum="C546AAFDBC75DA1D" modified="2014-11-26" version="1">[encoded data, 5726 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SBK3</accession>
    <name>A0A088SBK3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_251930</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699763.1">
        <property type="nucleotide sequence ID" value="XM_010701461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SBK3"/>
    <dbReference type="GeneID" id="22575841"/>
    <dbReference type="KEGG" id="lpan:LPMP_251930"/>
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    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_251930"/>
    <dbReference type="eggNOG" id="KOG0282">
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    <dbReference type="OrthoDB" id="10257301at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0005840">
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
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    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
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    </dbReference>
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        <property type="match status" value="4"/>
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        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
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    </dbReference>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
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    <feature type="repeat" description="WD" evidence="4">
        <location>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="AIN99056.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="521" mass="56339" checksum="A925DE22D2DE6305" modified="2014-11-26" version="1">MFPTDRLPTPADMVRLQAFRANGRAEAELATDAYLHSLMKRRNDSVAELLTLYTSPEDAHKVYPDPPPSLFQAADDASLVDKVAAAAAATSTSGPSSGATAQALKKTRREKVTEALSASSSVAAAGPSITRLVSAAEGSPAAAFVDGVERVDYLGKSFLEPPSSVLEHEQSTKQKACKPPRTMRGVFKVPEGYESAASADSAAGSSSHLVDQGVSIGGERRSGKASGVQQLCWAPPAYGHLLFSGDIGGECRLWNSSTRQLLATFAAHTQPIKSLEVTTNAAVMSTGSVDGTVALWDVESGTCAHVLTNPDRLPVVQHLHHPSNEAHLLLAAVDKKVVLYDVRVGCSKYQREYTGHMGTIFNLTLLSDGSKMLTTSEDRTLRTWDYRSPVQIKQFADAAMHAITHVLHHPTQPEFLAAQSLNNKVIVFRDDGGGRLRLLHDREFTGHTISGTRCQLGFSHDGRYLSSGDIGGKLYVWDWATKKLEKSFKAHAQMLVSHLWHPIEPTKVVTAAWDGHVKCWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SBK9</accession>
    <name>A0A088SBK9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphopantothenate--cysteine ligase, putative</fullName>
            <ecNumber evidence="4">6.3.2.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_251980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPC synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.5" evidence="4"/>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699768.1">
        <property type="nucleotide sequence ID" value="XM_010701466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SBK9"/>
    <dbReference type="GeneID" id="22575846"/>
    <dbReference type="KEGG" id="lpan:LPMP_251980"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250021900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_251980"/>
    <dbReference type="eggNOG" id="KOG2728">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="70224at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004632">
        <property type="term" value="F:phosphopantothenate--cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12290">
        <property type="entry name" value="CORNICHON-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/pantothenate metabolism flavoprotein C-terminal" evidence="3">
        <location>
            <begin position="101"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/pantothenate metabolism flavoprotein C-terminal" evidence="3">
        <location>
            <begin position="228"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN99061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="374" mass="41430" checksum="B225784C367496A1" modified="2014-11-26" version="1">MSPQGRLPDLIVIHTHLLLRHTPLSLLRSPPHTHTPPQVHSHSHPARSSETTKMQEVVDAFYAENISAEDQARLSAHQDTLISFLEGVTRSHPDCPGIAYITSGGTTVPLEVNAVRFITNFSSGGRGAYLVETLAERGWACVLLHHRTAVRPFRRALDELSTAQLFDAIASTTGAEFTPAPAQKAEVLHAAELYHRTKDLVHYIAFDTVIEYVFLLEVVSRALCGTAVPQVLQQRPCLFFAAAAVSDYYVPLPKMSREKISGGDELTLHLLSVPKVLLLVQQEWLHRAAPGATQPFIVTFKLETSEEAMKRKAISNLHAYRCDAVVANILPSYKEWVLIYTKDSDDSAPLLVRCEAAKTIEAALCDMFIPLSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SBU7</accession>
    <name>A0A088SBU7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lipase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_260220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. LDAH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699843.1">
        <property type="nucleotide sequence ID" value="XM_010701541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SBU7"/>
    <dbReference type="GeneID" id="22575925"/>
    <dbReference type="KEGG" id="lpan:LPMP_260220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260007000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_260220"/>
    <dbReference type="eggNOG" id="KOG3975">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="448051at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019363">
        <property type="entry name" value="LDAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390:SF0">
        <property type="entry name" value="LIPID DROPLET-ASSOCIATED HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10230">
        <property type="entry name" value="LIDHydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN99136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="314" mass="35032" checksum="2BEC08E59FE01B5F" modified="2014-11-26" version="1">MSSPNTIVAWKAPVAGGVVVDVLQSSSNLLQYLTTVESSNGGCELPNSNRKVLVFFPGNPGLVQFYEPMCACLEKNKFDVLVMGYAGHSLTQLNKGRVFSLAEQMDIADSFVATLINKNTELKYKRNIYVGGHSIGGFVALQMGARYASIKKCFGLCPVISHLRDSPNGRRLFYLSNTVTQCCVAMGAALLELLPYKLRHLLIARWEPKLSPALAEALAHHCHRWCLMNSLYMAMTEFRMLLQPDAVLLRHVQERLILYYVQNDGWAPLSYAEEIKRICPQLGAYVLEEDAGVPHAWCLDHSETVVRNAILKHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SDN5</accession>
    <name>A0A088SDN5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="11 12">3.2.1.106</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LPMP_282330</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(4)-(alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:55988"/>
            <dbReference type="Rhea" id="RHEA-COMP:12806"/>
            <dbReference type="Rhea" id="RHEA-COMP:14355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:59082"/>
            <dbReference type="ChEBI" id="CHEBI:132537"/>
            <dbReference type="EC" id="3.2.1.106"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.106" evidence="11 12"/>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700573.1">
        <property type="nucleotide sequence ID" value="XM_010702271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SDN5"/>
    <dbReference type="GeneID" id="22576678"/>
    <dbReference type="KEGG" id="lpan:LPMP_282330"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280029600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_282330"/>
    <dbReference type="eggNOG" id="KOG2161">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410058at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.110">
        <property type="entry name" value="Glycosyl hydrolase family 63, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031631">
        <property type="entry name" value="Glyco_hydro_63N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038518">
        <property type="entry name" value="Glyco_hydro_63N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF11">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16923">
        <property type="entry name" value="Glyco_hydro_63N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 12 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 N-terminal" evidence="14">
        <location>
            <begin position="115"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="13">
        <location>
            <begin position="431"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AIN99866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="947" mass="108325" checksum="AF4868DD7A7436FB" modified="2014-11-26" version="1">MRDRRLLLKKDAETDATEVSMPAESVQERYQRAKKRQAKDTRRGVLSYLLFILVFLGIPLLIVAHYTPFFVFQSLRCHLQEQYIWSDRTVQAMEDGYTRYFNEPPLYPSREYNRTMMWGTYEPSRIFAVKSRSLQPVTVGIAWYDSAMEHPLRHTMPYLHNKVNAPRTTQKKDSDPEVMQVMWTVNDGLHYAKEVVEDRGNKVSLEIELLKSPFADAWHVRIHGRVEGNSPLVMVVYMSHADIQERIELEAPTERNDGDWSPVLKSRMQPEGEAEHTDFTLRVYDDHSPLYDTAPWHVYGLHTDVEKAFQRTAVDAVGATPAERAAAGGRGIGGGAHVGELQQQQLDLRRLPESVFTYIQAKDPQSFQTPSSWMSHNIMILRKAYDSSFRLQLSLSPVDHAQSDAAPEASTTHRIGNPVPRYEALSTCQLTNALRWRSKAISLHSAKVFRPWLTVFNSTQGLYERIATSALAELFGSLTFTRGHYLHVSADVDDAWDQQGRAAELWSDKQLQASRQRVSALAAIGSRTDEAYGQPSLTGLLLLFLTRWNKEVAKDIFASWLLGAQDPETGFVPNRAVFSAETRSFTPRALRYEHPTMASPPTLLLGLEELLKEMSRKSARLASANRRKTRNTPEYFERERVADKAFLRTILPALKRWRTWWHRTQCGGATDELARHCRSRRPLEEWPLQPVEDQPESLLVYRWRGRDRHWLPTSGMEDYPRPICAGEHHREAHVDAFSWVALLSTLISRIETEFLHETESVRLDWEAHLNAVHWNATEMRYGDRIGCSSWTHTPYFGYANLYPVMLGVVRRDLSRAARTIALAQQELESDYGLMSVSFSSVRLARESGLPHHNMWMGYVWPSANLLFLYGVKSHYLEVLDSTSAAAGGLAETQLYNFYTSLRVNIIEAIRGGSRWWEYYSPLDGRGEGSKTHVATHSLLLGLLDNFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SEI3</accession>
    <name>A0A088SEI3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_292250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700829.1">
        <property type="nucleotide sequence ID" value="XM_010702527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SEI3"/>
    <dbReference type="GeneID" id="22576988"/>
    <dbReference type="KEGG" id="lpan:LPMP_292250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290024700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_292250"/>
    <dbReference type="eggNOG" id="ENOG502SHBZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="262453at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="467" mass="51291" checksum="D9D306E812901393" modified="2014-11-26" version="1">MITTLSSHAASYDEEVQGDSSKALAEKPFVDCVLIDIPIKYSRAFSFLRGIQLFFLDVVRKLNRVGMRDKRILFVTDCTINVASSQGQVSRGAKVEDIAELICNAETRAIGVRMRTRPFAITPQDFVRWNCFHEMSVDFLLLATSAAQYASLLQVMRFVYHTRTHEVLQCRPLRKREVWSASLVLAPDGSRVKKALQCHAITPILLGGSTSTATSCATRSQETSEHPGVAHVPSQSVALSAAIPESTSSSRQDMSATASTPRSPHSCGIRSFPPTSGAGGHRTALESLLLRLGSSVPLPLARFFGGTVVVPTAATLYCSNLLKSENVPNTSSEKDRSTTRVQPRLNLDKTAATGQPSDASGVFTSCNRERLTAVVARSRTTREDFETKATEPQLRDAELCHFRYSKECQLDEWMLRPNSFALNPYTSRYASSLWSPCSVASGSDIFYPMDDVKKTRPALSFPVVAHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SF55</accession>
    <name>A0A088SF55_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_302190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701242.1">
        <property type="nucleotide sequence ID" value="XM_010702940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SF55"/>
    <dbReference type="GeneID" id="22577272"/>
    <dbReference type="KEGG" id="lpan:LPMP_302190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300026200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_302190"/>
    <dbReference type="eggNOG" id="ENOG502SIFE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10263782at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="250" mass="27776" checksum="802EA30D58625E18" modified="2014-11-26" version="1">MRRRCLLVDTIRLLDFSGMEVVLLRCPKFYAKENLMTVFPEAERRAQFIRAAQASGESSEANYYLLYTFQSADFVRSEDLAMLDGGESQDLTGADDEATTGESLTAPSPVCPRLKTEDDFSELIRISPTSVEWKDRSRERFFSFMAAARARLEKYFGSANESSSCFFMDWPDPATGLPICTERGATIFSDADAIQQFFSFNSVLIAGPGGGCRMIEHPRFGLNIYPAVGVLVVPRDAEGSLCEVIRSFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SF73</accession>
    <name>A0A088SF73_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_302390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00462.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701262.1">
        <property type="nucleotide sequence ID" value="XM_010702960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SF73"/>
    <dbReference type="GeneID" id="22577292"/>
    <dbReference type="KEGG" id="lpan:LPMP_302390"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300028200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_302390"/>
    <dbReference type="eggNOG" id="ENOG502RZI7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="248322at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO00462.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1224" mass="130106" checksum="02B93C34A36019BE" modified="2026-01-28" version="2">MFKSSLATHSSIDHDLFPLLTVRSCVSEADESKNGPRFCAEDKMTGGAYEIRSRKLDLETEQRVSGAGCHRDNRNLSQNDLWAIKRQQDRINALLTATAHCAVPPCVTLPIDVYIQEQPSTGNTYVASVDAFSGLSLGDIIRSGWGVMEERVFLEILNAVEAFGYASASLPPHGNLSSDAIKQLLIVRDGASEARQPSRWVVSDWLLLSDDSVTSFDPQAFVADLEWVLHSSFAQLSISTTTAQGSALMPAARVEELVGETVDRIRAHLLQQDTGAQSSFSADGLTQLPGTGAQPDTKAVPAPAGVFFSEVANNNGVSTMQPSLRNGVGVARSFDTGCDKSAKWTFNTTEGGLESPATAAASMPSESRRECRSPGVTAIDCDTIAATANNAAVPTLSTSLTASLVNSMVQSSCRAASKRDSANDAYGAARQMSLKDKVAYHQAALRNEQLVVNKHRRKNAPLPPRPQPVLSQRRNVRQNLSPRAFADDAEVYYDPPTLTSPIAVKPSAYLMQSRRPLASGRGAGSARKLQSPHNARTPNSETQTPREPSRSTATSPHSQQPLATSESSPCHDQVRERLLDDVVTIAVLNQYRRTQDHRLRLEGERRRREQRQQILSLSTLHPGAVAQELAAPTPLEEPCTSVTNLPAPASPCAVRREAVNTENRRRVAPRSNTAQSSSAANPNHGSSAAPSRCCPVLAVATNGAAMSRVGTVSESPEPRPPSPRSYRMFHPIFCQKKPVVKAAAGTWAIPQREPGRGAATTAVVSRAAQTAVKPTTPSRTVLYGIRPDTLVRAERPTTVQTAVNARSARAREEVAVAATVGRGSNASRQPASGVDPRPGRSFAAAENGATGAVRQQQLSARKMGTAPLAQRRTGAATTSSLVSPRAKIAEQSAATPFVKPLSLAAVLGRTAFSPAGQTTTSARGPPHAPRLDARQQVSARRTATSFGMLPGLSGCSPQRSISGAKFEVPRSANTARPPPAQQHHGISPWVYRRVSSTGALHSPRNGVVITPCGQSATATLATAPPSSSPIRERPCSARQTATQPEAASPTGLHTMEPRLRNAANVSPAKGVASVNRTSMQRLEPKVWPKRWTGHARTLNIQKTDLPLTTANKESLASPCTPPLSAATAGDAAMTAARRDTFKGAAAQCSGTEVETRTSRGRDTGGSSTSTGARPTAASQKGMQKKQSNACGPVLHAGPLTLGRVRPVNEASPGILLRRNRRSPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SGD5</accession>
    <name>A0A088SGD5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">200 kDa antigen p200</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_313000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701682.1">
        <property type="nucleotide sequence ID" value="XM_010703380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SGD5"/>
    <dbReference type="GeneID" id="22577726"/>
    <dbReference type="KEGG" id="lpan:LPMP_313000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310038400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_313000"/>
    <dbReference type="eggNOG" id="ENOG502S49B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="251095at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="308"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="580"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="641"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="717"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="200"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="325"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="586"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="654"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="721"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="738"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="776"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="828" mass="93510" checksum="21FBF4BE9D1F98E3" modified="2014-11-26" version="1">MPLPREVSADAEADTPDHLRADYSFNISRRDSLASSRFSSRLSRRSSVRDEVQSVDEFLRKQRVIRYMQEERERAERSKLLREEHDFWIEFRDRERVERLKYMSEQEIAELLQREADEATRESSGADQAHQRAMEDALRRRHSMADLRRMEEDAVLARLKSEVLTDEIRRAAQLEALEKAEAMAATEHARRVSVHLQQREEDLAAKCKQLTAELEEAKAAATQARCYQKRAEDELAREREKMLKEKAAAAAGKEMNEKLLKELEEVRQHLTASEEEKKRVEAAKAQAVWDVAQEKELSSLRRCNDELVAQQASQKAVSEDEKQRSSPLQEELTASRNELKKERAARSNTEAELVALREQAKVLETKLAAAIAPEPKQEADTIRKLKAIADDARRAQADLLKERQVREKAEAAAAEAKGALAKEQAAREKAEEEVQRAVAASTVTALQMENAVSDRKKLVEAEKKLEKMRKERNKDEAEKAALKRGLQKVKRDLEDESAARAQFEQLASKALSADHHVSQREVDQLRRELKISQEQCDAARQDTVVCQQNAVNEIASLRAWCERLQKQHRMQLQLLEDDDEFTPRMATPTPHSRSPSSAPRRMPKKGLAAGQRQADERVASDQRIHELEAHVMRLQADLQKNKEQEKKALKASAEGSSSDSQKTSPHQILSGATTEQEVREMALVDRVNALEREGAETRRKYDDLVVAYRRSEAARCEAERQVAAQQAQAEQLQKQESQPHTPTLANCETTRVEPIVGAAEGNTSSLPERISNLEGHLMEERATHEPAEKRGAAPRVGAELAVKQAGASFSASVSDARAPPQKTKSGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SGU3</accession>
    <name>A0A088SGU3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_321510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701837.1">
        <property type="nucleotide sequence ID" value="XM_010703535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SGU3"/>
    <dbReference type="GeneID" id="22577892"/>
    <dbReference type="KEGG" id="lpan:LPMP_321510"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320020700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_321510"/>
    <dbReference type="eggNOG" id="ENOG502RKYP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="250704at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="880"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="330"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1093" mass="117784" checksum="CE3E07FF149FF7C6" modified="2014-11-26" version="1">MKIMGQPPPGAKIIAGAPPPGFKMVHSIPAGAASPPLNSTPKSVSRDNISPNSMGIPTKTPIKMLPPGAKLISGLPPPGLRPISPEGAQQGATNPSLTPSRSVSPTNPPVFRILPNGVKVLVSPPRSGASVSAVRTLPGHPSASPPKMLIKSMGDSSSSGGAAVAPTLRTTVPLIPPQNGSFAVGPQASPPLHPGLPKPAPLRPGGTIVKVSETPARAQSEQHQETSAAAVHRSDGQVGMQRSQVDEISFHDENGTGGSRDDEIQFEEMTPSIPPQIPRASAAAEVIPGTSSSSSSSFDLREDPDEVTALPPLKATEGSATPRAAASPFSSLSAGEAAASEELKQRLHKHGLKESSKGSRKNKRRSHRAPPQDTVDDDKPSHKERREHRHRHHRSRSSETGHASRRSASLQSYSGPGASMSTSPPVVDGTLRRSPSQRAVASGNSDHVDTPEKVVMDQLRKDAFTPQALTSISRDRIAENFLSILCPQQYYGKVQRISRIRAFKADRAAAIGLRNSNSIYVATKGVMPNPYFYPQLRLRNTDGERLRSLSDADNVVEGAVSTPIILYEAAPGNMVFADTELDARHLLESNGNVNSCFMISNSAILFRNPEHYVVPIAALNVHWVPYTSPQSEPQCPIHKRELQLFDRCSKELVCVLCASRNGISVENFVVIPDVLGNVDSRRTIEQKMSIQLEEVQQSSKRWVVQHQRVRELCESKKQAIHHQFDLLIEALEAKRKEYTESCEAEFAYALTNVAREILITDEKVELLRAATEHVRTDPSKPLFSMQIATIAEGLSAASDLPSRFTRASLKLPPMSAGLVPNLEGVMSQVLALSPQLASSGGVGGESRMESRLLTHSKPHNGRRLMEDAVNIENEDRWHSSWTGATSAPASAKSLRRSTRFASSTTSPRPVLSGPVARREYTSGASASLHTRYAARATSPTRFATDSVSVPNSTGTSLFDFALHDLLSSFGTPHAKRRPPRYVQWAIRVENPGDWVGLGVGVGSTIDAWEQGSTNDLSHLWIVPVGMMGQVVYLRVAVNASSGHAKLTVHDARGKQLDAGEVPHWNAARPSYPQATFGGHIGTVRMIEIPHLVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SID6</accession>
    <name>A0A088SID6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_332960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702387.1">
        <property type="nucleotide sequence ID" value="XM_010704085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SID6"/>
    <dbReference type="GeneID" id="22578449"/>
    <dbReference type="KEGG" id="lpan:LPMP_332960"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_332960"/>
    <dbReference type="eggNOG" id="ENOG502SK72">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267914at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839463" evidence="3">
        <location>
            <begin position="40"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO01587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="394" mass="41534" checksum="0F81DAB0C8EAC9A0" modified="2014-11-26" version="1">MVHPSQRGRSDGRYRTTVLCAFLALALILAALGCTPVRAQHRMRELEERERNASENADKIAGGSGHKDYEAATKDGLFRDADMQTESSSDSVESSDMVTVSQSGAVSSSLETVDAPSTEQGSSSSVPASSARAQPNSSSSSESSDPSIASSFSEINKGEQSNHSGTSAIISTTTTSPSTTTTTATPTTSHSTGGDGKSTVVAFLFFIVFIAALIMYSGRLCPSKCPFFDYNGGRPGSGLRLEMQPQLQRYTNLRGNEGGRDIFVEMGGKPTQRMRDSGAHHDSGAMDSFSFLVQNNPAAVYEPFGSSGFSAGPEAAQAPQTFENSLKSLRKGMRGHTSTTAVSSPVPATTTGTLGFGTGSPLACSTADTRSSYTGTITTPLTKMTPRVEEDWEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SIX1</accession>
    <name>A0A088SIX1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_341400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702567.1">
        <property type="nucleotide sequence ID" value="XM_010704265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SIX1"/>
    <dbReference type="GeneID" id="22578645"/>
    <dbReference type="KEGG" id="lpan:LPMP_341400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340020000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_341400"/>
    <dbReference type="eggNOG" id="ENOG502RXNA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273058at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="617"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="617"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="678" mass="74433" checksum="6BB17A54137E5746" modified="2014-11-26" version="1">MSVVGAFYDEFLLYTQQRSSEVRLTHAAEAAMLRCLDAERASEALEVYEAVCRCGVVGMSSRPLGRSSCRTSPTRTAPHMCTSLATISLDQLAQRALAHVPHRKFQHSMLSLLMAAELDKPSPTMDYGNSRRAAGLSSGSGDLKASSGNAYAPQTAVADEKGVSVEATFLSHAGDPSAAEQARIRVQQRLHALHTTQQLRQPLGKEYCLVEMLQLCAPSAVGARASTAARKVTDEIEVSPLRTLSHVVLHHPFTHMQPSAPWAQKEMHWEEISLRVCAQALTPANLARLTKIEDAVSPYRLFCKSSLMFLARMVPNWDAVLVRRVAETLVLPATAHSVFPESYRRLLPTAAQRRRPSETAALSTPGAACGQLATPRCCTSWTDSATHKLFGEESGDNHASPLLRVEHLVKRRVHHDVVVPDTSYMLRHFQQLKQLARHREVIVTHSVFLDLVAAASLPTHPTRFHARRVLRDIMYATTTAVTGKQSNEAGGKWDVRSVASGSRRRDQLQQSGFTLLGLQDELALLERCPERFYLSEFSSAASLSDWALMGQWISLDSAARVSDVEYGSQSCVALVAKQLERMIATHDRGEDFFANSTGAPTRTHVGVDSLVQHILESNSNATSPTTPSSRQTTGPLFKNRSRGLWARMPVVVATTHDRTRAAAFTVGLRMYPPAGLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SJL1</accession>
    <name>A0A088SJL1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sperm-tail PG-rich repeat</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_343800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702802.1">
        <property type="nucleotide sequence ID" value="XM_010704500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SJL1"/>
    <dbReference type="GeneID" id="22578885"/>
    <dbReference type="KEGG" id="lpan:LPMP_343800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340045300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_343800"/>
    <dbReference type="eggNOG" id="ENOG502TMNZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="406368at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051291">
        <property type="entry name" value="CIMAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010736">
        <property type="entry name" value="SHIPPO-rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21580">
        <property type="entry name" value="SHIPPO-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07004">
        <property type="entry name" value="SHIPPO-rpt"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="476" mass="51030" checksum="1BAD6AEF20D46B00" modified="2014-11-26" version="1">MEELPLLRAKGNNVRETTGPSVGPGAYDLDKRATINSSCAPFNSTSVRQPLLSADRELPGPGAYNVPAAQSGQAFGVGSQPFVSESARFVAAACSDIPGPGSYDVASYRSTRKNPRSHMFSGPHGNALDSQYTESVGPGSYNPNYVAADRRLPKAAGFAKYSSREPLRPPTGPGPGSYNPSLVLRSLGAAKPSSMFVTKTKRSLCGGNGFSDSPGPGTYQPWMASERGATIPREQFSAFGSSSSRFAHGKEGDLPGPGAYTGEIAPRRFHPSTKGNSAAFVSGYDRFPASMVAQSPGPGTYDPRRSRRHHDFGEPMPFGSTVPRFDPVWSQHPRSEPLIFSGDPDNGRAPSQRRMRPFIYGKIQPSSAPPPLPHRAYDVRYDWPKPTSMANTTFGTSSRLPLHQTSAVPGPGSYCELGDAAPAGRRYGNSNWGRYVRFSEVALSSGTPEAGKYYHASTFLKKTFNSTIGSDTAWIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4L2</accession>
    <name>A0AC62A4L2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Heat shock protein 83</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">HSP83</name>
        <name evidence="1" type="ORF">LPMP_3320050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="XUY36713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="705" mass="80907" checksum="AF8312B058703C87" modified="2026-01-28" version="1">MTETFAFQAEINQLMSLIINTFYSNKEIFLRELISNASDACDKIRYQSLTDPSVLGEETHLRVRVVPDKANKTLTVEDNGIGMTKADLVNNLGTIARSGTKAFMEALEAGGDMSMIGQFGVGFYSAYLVADRVTVVSKNNSDEAYVWESSAGGTFTITSVQESDMKRGTRITLHLKEDQQEYLEERRVKDLIKKHSEFIGYDIELMVEKTAEKEVTDEDEEEDESKKKSCGDEGEPKVEEVTEGGEDKKKKTKKVKEVTKTYEVQNKHKPLWTRDPKDVTKEEYAAFYKAISNDWEDPAATKHFSVEGQLEFRAIMFVPKRAPFDMFEPNKKRNNIKLYVRRVFIMDNCEDLCPDWLGFVKGVVDSEDLPLNISRENLQQNKILKVIRKNIVKKCLELFEEMAENKEDYKQFYEQFGKNIKLGIHEDTANRKKLMELLRFYSTESGEEMTTLKDYVTRMKPEQKSIYYITGDSKKKLESSPFIEKARRCGLEVLFMTEPIDEYVMQQVKDFEDKKFACLTKEGVHFEESEEEKKQREEKKAACEKLCKTMKEVLGDKVEKVTVSERLSTSPCILVTSEFGWSAHMEQIMRNQALRDSSMAQYMMSKKTMEVNPDHPIIKELRRRVEADENDKAVKDLVFLLFDTSLLTSGFQLDDPTGYAERINRMIKLGLSLDEEEEEEVAEAAPAEAAPAEVTAGTSSMEQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4U2</accession>
    <name>A0AC62A4U2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycan beta 1,3 galactosyltransferase 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">SCG</name>
        <name evidence="1" type="ORF">LPMP_3220010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="XUY36701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="590" mass="66163" checksum="1E293E595697BABB" modified="2026-01-28" version="1">MAGGRSDQEAKGLPVFATTSTPLGLMGPMLFAMASVTDDVDVAAELPLWSWVSRSYAQQRHLANASPWKSKSTQPQHLVVMGIPSTDQPMRYPLRDAQRATWLTYREVARAENSFTGALLQLYVFAAAERRSDDSTRDTVDTTQLAPTVNEYAAANLQRLAVEGGDATNAPSHVQRRVVLRDGWRDVSKADGAVWESPCIGVKASVVSPEGIVGGASSLAKLSSALSLPATPAFTSAARYMCHVSTALWQEVLHHRNSLWLDLLTDRHLTTNKKMGMSNSWGVPTEVGMSQKVVIWLNYAYTAFPDVPYLMKGDDDMYLKVPQYLSDLRYMQRGRWGRPRNLTATIPHDDVIPATLGIDDTRDCLYRVWRLYTSCIIYGNGVGYILDRRLVQAALNPFDSSNALLLKLLTEPYNSSLYNEYLSLIMQYEDVLVGKQVKDHLGAVRQLCPGRRVCYMADRRSRAHQILRPAGSRLTWNSVMTHFGMPAIPYYVHYFHKNELKVAKEAKRLIERGFDVNAIEANATKYMENWVASQVPKTLVGLGSVLDLSWVRGRPRTTYVVAEEDDVAVYDVRYKRAKAHITKCVWESGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4W8</accession>
    <name>A0AC62A4W8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3420350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="XUY36799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="430" mass="45647" checksum="BA21ED546DCD09F6" modified="2026-01-28" version="1">MDPTTAVYVRQHYLASTTHSVAQVLCDMEGDLLRHPRQCRTGELAAPEAMRASVDTTLPLQLLLSSFTTTSLSANPGGESKISSKLASSSLPAQDAAGSERATAAASQAAASDLSHCLRPVDAVFASKDDAAKADICRCIALHCERALTGLGLVESWGGRLRWAHVAPDGDGGGERLGVALALDAFRCWQRVVLPLLQRIRDPASRGLTADTATAETLFDYLVKRPAAVAVPRSDASSPLAPAFTCEEAAYWCFALLRGYCQDFPETVWTSILRAAQDAAAQQSSSNAVCLPPLPGEALLLRSFIAHLACSETNTACVTSAPALGQAKCGAIIASHMSSAVAAARARAEFWVWVEVELLQRTFADTKVSDSSLSALLCRRVLGCTDAAVHSHARSVLHVVLVLGGSTSRHRRIRCTTDAVSVERADTHMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4Z6</accession>
    <name>A0AC62A4Z6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycan beta 1,3 galactosyltransferase 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3420010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="XUY36760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="794" mass="88126" checksum="A528B5852EB1EE94" modified="2026-01-28" version="1">MHRNASLVSQNSSVLSGPANTSNFCDCTRGRAEPDQAWLLGSREGDAASLEKDDGFPDEAALSLPFRFCRHLRGFAAQAVHSRTQRRRLVALIILPAVLVTLYYIGSFATAGHSRQSHGSIELQRKLSTLLDRGTFSVLVQHESALQRLASAQHALDAAAADGKARLRSDQLPSWTLRVIDNNCTMCFDRVTYGAAVARGYGEMAGGRSDQEAKGLPVFATTSTPLGLMGPMLFAMASVTDDVDVAAELPLWSWVSRSYAQQRHLANASPWKSKSTQPQHLVVMGIPSTDQPMRYPLRDAQRATWLTYREVARAENSFTGALLQLYVFAAAERRSDDSTRETVDTAQLAPTVNEYAAANLQRLAVEGGDATNAPSYVQRRVVLRDGWRDVSKADGAVWESPCIGVKASVVSPEGIVGGASSLAKLSSALSLPATPAFTSAARYMCHVSTALWQEALYHRNSLWLDFLADRHPTTNKKMGMSNSWGVPTEVGMSQKVVIWLNYAYTAFPDVPYLMKGDDDMYLKVPQYLSDLRYTQQGEWGRPRSLTATIPHGDVIPATLGIDDTMDCLYRVWRLYYAGDIIYGNGVGYILDRRLVQAALNPFDSSNALLLKLLTEPYNSSLHNEYLSLIMQYEDVLVGKQVKDHLGAVRQLCPGRRVCYMADRRSRAHQILRPAGSRLTWNSVMTHFGMPAIPYYVHYFHKNELKVAEEAKRLIERGLDVNAIEANATKCMENWVTSQVPKTLVGLGSVLELDWVRGRPRATYVVAEEDDVAVYDVRYKRAKAHITKCVWESGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A589</accession>
    <name>A0AC62A589_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Qa-SNARE protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2820020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="XUY36919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="236" mass="27324" checksum="BD1B529C3C80E8FC" modified="2026-01-28" version="1">MEELRQKHAENMQTVDETRSKALRLEIDELSREASNAARAAKDKLDAMSRNTANLKKTPDSVHANSAVIRIEENQHMYLVVKLATIMAEYQRHQSANEAFYKAQTQRQIKIKYTNLDGSAIDDSIAAQLAEQVMENNTSSYIFQQSKEVLASIIETRNDIYRIEQSMRELNQLFNDLALLVNEQGEIMDVILANVQRSIRYVEKGSAELKKGRKYQKKSRKKLICSVARIRMWKRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5E9</accession>
    <name>A0AC62A5E9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3420470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="XUY36811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="506" mass="55787" checksum="FD5AC212EB161D11" modified="2026-01-28" version="1">MPTCSSATVTGESRSCACAVLPTIPVRPPLPRATMLGRAGNTCTSAHPRSLREAAMPPRGDAPRCARQRHCLTHDTTLSHPRKDADRAQAISGINHSSSLNSTAHWPLLGKRGCSLWALSPATQRRSSPAPAAAPEAVPLRPPHPPRSPPYALGCDRGRSSDNDCSIFPPPRALPLYTTEEELPVCIDPEGVRCCPLLNPQCEEGVVTAAQINLSPFLNWKFVPYLPPQAEDQARSTVVLDMDETLLHTSVAPMPDADAEIDVPYPSDDARDVKASVTLPHYKLFVKYRPHLEQFLLFCLDHFEVVIFTASKALYAQAVLRQLQEDFPGIAIRLDDNNLSGGAPASPHARGEARIIELLHRDHCTPTNVGYTKDLHLIGRDLRRTILVDNRKVCGVFQPYNAVHVKDFARRRCAERVPEEQKMQAMHLRQLERTIPASAVEVAEDVATSRLLSTSGCSTSTYDWEDREDTVLLHLCAPGGLLHCLSRCEDVPSFLQRTMRFNRAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5Q8</accession>
    <name>A0AC62A5Q8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Surface protein amastin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3020010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="XUY36951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="198" mass="21328" checksum="88301226CF1AF545" modified="2026-01-28" version="1">MGFEALHGRMDVALNMLCSCTVFMFLVTSAPISQFRGSGIRTDGSGGASKLACVTSWGLKNDCNNNHYDYRSTSITCARSRQLFQVAQAFYIIAVIVSFLSSLLSGLYFIGIKAKVALIVLGFLEVVVALIPWVCMTAVWHNDYCGQSTVMINASSGKANGVPYGSVLRTAFKMSAGYGMTVTAWCVQVVGLTLLLTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5X5</accession>
    <name>A0AC62A5X5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amastin-like surface protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2020470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="226" mass="25340" checksum="BE79E4906E0BF8DC" modified="2026-01-28" version="1">MKWKSCVVAYAILQAVAFLLVLVATPIDMYRFRPRYITPNTTVTTLWGVKKGPLNTTNVIPTYILWRRCPARANRFLLAQAFAVISILIYGAATVLGLIMLYCCHWLRVVCVALNGVGALTVCIVWAAVAVTYNTYEGPDCWQECVFSTYGTGFIFLLLAWILDLLNMVFLLLPLTIAVGPEDENREEECKEYVGVYSGEMLNESLRGSSNGVYKQNTLPEDSSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A650</accession>
    <name>A0AC62A650_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amastin-like surface protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2020210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="211" mass="23604" checksum="5A296B6FDC4D06F3" modified="2026-01-28" version="1">MSKFSSDNSQESSVTGSESTETTEKHSTDSDLQVSLVKGRIGLIVYVIVQFFAFFFVLFGTPIDMFRLRSSPSSPDRSVVTTLWGLKLGVFSIRYGQNSDERWRNCTSRLNRFRLAQAFALISIFVYGTAFVLGLILLFCCSYLRWVCLALNIVGAATVCVVWAAMVVTFYRNESSCLELGSIYNYGSGFTLLVLAWVLDILNIISLLLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A663</accession>
    <name>A0AC62A663_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amastin-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0820130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="XUY37293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="187" mass="21222" checksum="1C375EC562EFF343" modified="2026-01-28" version="1">MEFTLVFLLYAVLQFIAFLFVLVATPLDMLYDKNGSRFDNRPCVTLWGAKDECYGLTYEMTSDEAWNVCPVRRNRFRAAQAFAIISIFVYGLAAVLGFILLWCCSHLRFVCLALNVTGIVTVGFVWASILVTYYKTEFPCLRENLYTVLGSGFVLLVMAWCLDIINIVLLLLLWQAAHPSESGETKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6A3</accession>
    <name>A0AC62A6A3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATG8/AUT7/APG8/PAZ2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0920110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="XUY37328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="124" mass="12846" checksum="4224028B6550883B" modified="2026-01-28" version="1">MSAYVSSTPLEARVARCASLRATNAVPVVVEEAQARGGKAHFSALPRETTAAQLVAAVRAFRGVAANKPVTLTVAGCSVSPSATLGELHDACKQADDGMLYVAYTAERSMGAATWKPCGSCSWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6C2</accession>
    <name>A0AC62A6C2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amastin-like surface protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2020820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="189" mass="20857" checksum="5081DD30BE454C38" modified="2026-01-28" version="1">MGLNTVFVVYAALQFIAFVFVVVGTPIDMFRVKPMFREGTVPCLTLWGGKFHCFDLSYDFRPESVFVNCTSRLMRFRVAEAFAIISIFVYGAAFALGVLMLFCCPIGRWICLGLNIVGAVTLGVVWASMSVAYTVDEMNCSMLSFEFHYGAGFALFVAAWALDVINIFVVVLSICTTASAESGQVEHKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6K5</accession>
    <name>A0AC62A6K5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycan beta 1,3 galactosyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0120020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009370">
        <property type="protein sequence ID" value="XUY37387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="813" mass="90411" checksum="A59F7066B496E4A8" modified="2026-01-28" version="1">MRNERDIIRKAVPVEPPNTMHRNASLVSQNSSVLSGPANTSNFCDCTRGRAEPDQAWLLGSREGDAASLEKDDGFPDEAALSLPFRFCRHLRGFAAQAVHSRTQRRRLVALIILPAVLVTLYYIGSFATAGHSRQSHGSIELQRKLSTLLDRGTFSVLVQHESALQRLASAQHALDAAAADGKARLRSDQLPSWTLRVIDNNCTMCFDRVTYGAAVARGYGEMAGGRSDQEAKGLPVFATTSTPLGLMGPMLFAMASVTDDVDVAAELPLWSWVSRSYAQQRHLANASPWKSKSTQPQHLVVMGIPSTDQPMRYPLRDAQRATWLTYREVARAENSFTGALLQLYVFAAAERRSDDSTRDTVDTTQLAPTVNEYAAANLQRLAVEGGDATNAPSHVQRRVVLRDGWRDVSKADGAVWESPCIGVKASVVSPEGIVGGASSLAKLSSALSLPATPAFTSAARYMCHVSTALWQEALYHRNSLWLDFLADRHPTTNKKMGMSNSWGVPTEVGMSQKVVIWLNYAYTAFPDVPYLMKGDDDMYLKVPQYLSDLRYTQQGEWGRPRSLTATIPHGDVIPATLGIDDTMDCLYRVWRLYYAGDIIYGNGVGYILDRRLVQAALNPFDSSNALLLKLLTEPYNSSLYNEYLSLIMQYEDVLVGKQVKDHLGAVRQLCPGRRVCYMADRRSRAHQILRPAGSRLTWNSVMTHFGMPAIPYYVHYFHKNELKVAKEAKRLIERGFDVNAIEANATKYMENWVASQVPKTLVGLGSVLDLSWVRGRPRTTYVVAEEDDVAVYDVRYKRAKAHITKCVWESGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RH62</accession>
    <name>A0A088RH62_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Exportin-T</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Exportin(tRNA)</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 10">tRNA exportin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LPMP_020080</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <text evidence="10">Shuttles between the nucleus and the cytoplasm.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009371">
        <property type="protein sequence ID" value="AIN95188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698153.1">
        <property type="nucleotide sequence ID" value="XM_010699851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RH62"/>
    <dbReference type="GeneID" id="22571818"/>
    <dbReference type="KEGG" id="lpan:LPMP_020080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_020005800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_020080"/>
    <dbReference type="eggNOG" id="KOG2021">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26399at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071528">
        <property type="term" value="P:tRNA re-export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045546">
        <property type="entry name" value="Exportin-T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040017">
        <property type="entry name" value="XPOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952:SF11">
        <property type="entry name" value="EXPORTIN-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952">
        <property type="entry name" value="EXPORTIN-T/LOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19282">
        <property type="entry name" value="Exportin-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="5 10" id="KW-0820">tRNA-binding</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="968"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="domain" description="Exportin-1/Importin-beta-like" evidence="13">
        <location>
            <begin position="108"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Exportin-T C-terminal" evidence="14">
        <location>
            <begin position="497"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="776"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="776"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF19282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AIN95188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1165" mass="128760" checksum="C11BC55BC3FA05D1" modified="2014-11-26" version="1">MTSPESFTQALQLTHSFDMSVSYNARLEAERYLMELRESAEGLKLSFHIINEAADELRCFWAFNTVIHHLPMLAATVDAVQAQELYRTLLLFIHRYLFEPRTVAPVDYVINKHAQMMVVGLQMFYPARWQSFFDDLFEMLSRCPPSPYPSTADLVTVYVLRIFEYIDERVVCARDRQERGKQQQARNMELKDAMRERVIPQAVAMWYNILLSDARVRNPNMAKLCMTVIHTYIEWVDVGLFLTANWINLLHFLLAVPPLQVAACECLLALVEKKQLPGMKMESLRTLSVVDSLPRMVSLFELPPPSEAAVLFIEAVAKFAVAVAGQFLALLESSSSLAQQQPATHSAAVVEVNGMVLQDQPFTVTTDLLDGLAGALHAVVAQVIRVLQLNLFDVRDALLPFLQVYLKSTYLLESEAVELLATLFHQTRIPGVVYHEDRVWEDSVIDQRRALHNLLRLLHRRHPGIVMPHLHSVFFTGLNRLNEGGSIVKTSALKDDADFTDPEVLEAALRYLYEIGESLRLDSLKDPNDTVTQLLQRLLMTEAVASGEATCVHLAFFEVLSRYYLFFTYHPQFIPLLLQRLLLQPCGVVNRSDPVRARICYLFGYLVQVLKGQLVTYAADMVNALHSIVTTAPQLQPSDRRELYEATGILLSICSEEARTASDNSSPEALRLLAASATLDSYGATVLSTAVLTEVATLLGRKAELVRIVVGSALHSLQQTSASCPAMNGNATGSSNLAATGSVGVADHTVADVISFLSALAKGLGNTESSTGAELVAESGVNSSSASSPNGSVGEQLPMCSTPNTSSLAVGRPLTACGTSSDAPLSTLPAMSRTNVLVAQVFLHVTQRVMEVLNQLAGSSTVRESVGQLFHQLINTLPYEMLRPYIEEYVAVCLNWMETIPELAKLLRLMFQYANKAGNRGVLSVARLTSLLWQRLCVVGELSEASPVVCLGVVSESARERVSLYKQFFTFLFSVSAWGCVAAFGLMPSACWISILRQLCYALTLPAELELPKAALQVLEKLTQELTDSVVAQAVAQYSSAADVVDAATAQRNQQIFRECLLQEALPTAFSALTDLSFDLDDAKNFLLMGEVLHFFRLLVARYGDPAMQVLYERVAPYVGETTAMECCTVIRDQPRVNAALKAKMKQLLSHVHASRRQTPAHLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RH74</accession>
    <name>A0A088RH74_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CWF21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_010190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009370">
        <property type="protein sequence ID" value="AIN95120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696662.1">
        <property type="nucleotide sequence ID" value="XM_010698360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RH74"/>
    <dbReference type="GeneID" id="22571748"/>
    <dbReference type="KEGG" id="lpan:LPMP_010190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_010006300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_010190"/>
    <dbReference type="eggNOG" id="ENOG502S6AD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10267305at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013170">
        <property type="entry name" value="mRNA_splic_Cwf21_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM01115">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CWF21" evidence="2">
        <location>
            <begin position="67"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="192" mass="20678" checksum="3F34472549709A08" modified="2014-11-26" version="1">MYNGVEAVSIKGTGLSGYVQRSRVNVSAAGCAPVEEGTMAAEGGSSINPLEQRRAQGENREMAARLESHHALREVRLRVLLYREERQAAGIDAATVERECGELYESLLVAAKGRLKAQQKAENAKTAAKFAAAFGVKSTTATTAAGSGSAFSRSVQEAEKRRSEDERRSRQEAQLVEHLKRMRSEASNAAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHJ7</accession>
    <name>A0A088RHJ7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_050110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="AIN95452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703774.1">
        <property type="nucleotide sequence ID" value="XM_010705472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHJ7"/>
    <dbReference type="GeneID" id="22572089"/>
    <dbReference type="KEGG" id="lpan:LPMP_050110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_050006100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_050110"/>
    <dbReference type="eggNOG" id="ENOG502SA66">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270962at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN95452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="123" mass="13891" checksum="725E5AE423E09945" modified="2014-11-26" version="1">MQTCRLLCLQFLLNTPFDHQPITVPAVPTARFIIEGITPPKSELSRVDEVGLLLKHLPTACDEAKQLQHDAQYASRYYRARFNRGSQLQLKHATHVAAASSAAEVQQWARSRLHPISDPFQCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHM9</accession>
    <name>A0A088RHM9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_030300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009372">
        <property type="protein sequence ID" value="AIN95265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700973.1">
        <property type="nucleotide sequence ID" value="XM_010702671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHM9"/>
    <dbReference type="GeneID" id="22571896"/>
    <dbReference type="KEGG" id="lpan:LPMP_030300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_030008000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_030300"/>
    <dbReference type="eggNOG" id="ENOG502RXAZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273239at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="638"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="642"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="679" mass="73271" checksum="5F83115AFE948E86" modified="2014-11-26" version="1">MRVVRRMPVVSPHRCSPLRLWGDDPCSAVAVALSCQRLWIKSTSPLACSTSNFERNLRRCRSPGRAAEHIGPNSGKAEGAALDEHQWDEHTGIFQSQRIKPFPVRAAIDIGAGGVASLCVARVDATVGAIQKLLYQTQLPLHLDALPTSMSNSASPLLSPSFMLSERTMKDITNKMRILQGAMRRNTFEGLSERAAVLSWPLCLARNAGQLAEQLTREFKIDVRVLGTNFAVEWPSSVPRPLTDEDTSTPEAADAGSSTVGKDIQNGAARKSAESKLTSLLCAARAATAAELGKRRRKATTPPSLGSAAVHGVMDPHAQLDTLAFLAHAAVSQCVAPQRLLVLHEDPQRGLRLLGLGTSAAEDIADLLDNATAPEERQKLYDIAYGPGTLSLEASKTPLLESRTLPETHAQQRHHASSSPTMTSTRPFKSPMGSASSDVAAAAAATSRMQLVEHLLPVDVASAHRYCITQIQRRPLESYSLHASSPNPLLADEFAALRGLLAGIVQPTLPAWVRRKAQLGGVLCGTSHNGGLLNIAARMSQQTHVSLEHLEVHAQYHFGGLTDVLLAESFPNPLLALPSAALTAAVLRSLESPRITYLPEVNVAAALLVQPSLWLYARATQVRARLVRDPFYGSATAAQRGRTFDRPHRKDNPTAAPDATWVKQGRWNPISHNESMRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIA8</accession>
    <name>A0A088RIA8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_061180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703999.1">
        <property type="nucleotide sequence ID" value="XM_010705697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIA8"/>
    <dbReference type="GeneID" id="22572324"/>
    <dbReference type="KEGG" id="lpan:LPMP_061180"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060018200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_061180"/>
    <dbReference type="OrthoDB" id="264318at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="298" mass="32933" checksum="C29A56C30761C436" modified="2014-11-26" version="1">MPSYPHTTGACRSGDMATGTSGKATRRRIVCCAAPTTTVRVAEIYTLHAKENDPFKSTVCMDYHVLSRIEGDLRRAEMRQENPESVMPDRGYLHDQEAYRTWDEYITTKQSPSSNRSVVGSLYPSSRGESRLPPIMLPRARSRRGSASSSRYASVPNSTLNTPTSNRRSGAPGSNRKGRQMSRSPSPGGQAHSSVHSSPWQHKGSSPRHQLPSLYPPNDRLGPAHSTCKTPKWRKEAGYCEVNGAAAAWNSHKTGRKHSLELSELEEGHEQQTVTDAERERRLHLAGELASRMESAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIC5</accession>
    <name>A0A088RIC5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_070160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009376">
        <property type="protein sequence ID" value="AIN95702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704024.1">
        <property type="nucleotide sequence ID" value="XM_010705722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIC5"/>
    <dbReference type="GeneID" id="22572351"/>
    <dbReference type="KEGG" id="lpan:LPMP_070160"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_070006400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_070160"/>
    <dbReference type="eggNOG" id="ENOG502SJHD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265298at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013861">
        <property type="entry name" value="TMEM115/Pdh1/Rbl19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377">
        <property type="entry name" value="PLACENTAL PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08551">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="321"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN95702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="349" mass="37923" checksum="D549F7E45FB93CF7" modified="2014-11-26" version="1">MPLLPSLGTRAAKTPVTAVLLTLVCIIVLLSNSNDLTCMHGTLYELYPWRFITYSLAATIQEPWRIVVNTAVVLAGASAEATTGSSEYAIFLLFTTVATGLLVLIADLIICHPLRFAFLNKDDSYNRPYGYTGMWPVAEVIGFSLCRVRGMSALVGPRLLGAQLTLQQVPLAIVWFAFSCDVVSLVVGRCLEEYYDHWEGWRVMVACIALLVSWLYERHVTGAASSAFTLDAFIYPEPLRDCVRSVGSRLQRLLQVSPLRALLPPEGGASGEAAMLPTPLFSRAEMGSVFPSKSNTATALLPGTTAEEAERHRLIAREALARRLQQEQQAQSPSTSLGVEAADSAAKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJJ8</accession>
    <name>A0A088RJJ8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_090690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN95985.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704307.1">
        <property type="nucleotide sequence ID" value="XM_010706005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJJ8"/>
    <dbReference type="GeneID" id="22572639"/>
    <dbReference type="KEGG" id="lpan:LPMP_090690"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090012100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_090690"/>
    <dbReference type="eggNOG" id="ENOG502SM8F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273590at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN95985.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="370" mass="40342" checksum="4CEB872F20DE50C8" modified="2026-01-28" version="2">MFPQGLIDQWLSKSREGRRSVREDPKATPAILENINRLEEYCRRRPYDVYCASTLQNPPFALHALECEAAEQQRLAQPPPVFLVTAPSPSAHTTASNEVRSGVCGRYAGGEESRASVVAAGQHLHHVTTRLAAYLESSGMMSSAAGLHEEGSQCIAVADFFVRLLSEAAVAAMYRQGVAAQAETEERETFQHRQSRRRLQLRVNSEDVSTRRRLELSGGRGAGHEAAHEFEDPTVARPIADLRRLSQGLVSLWGLLAQTERHGGQAAGGLPLKKRSRDGAADSGAADDDDNLWTRVRVGCLRHWLGDRAPPPPPPPLGTAALVETQRKAEASSPTPPGGTWSSWQLRISERDVEFALRKVVADVTASEGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJL8</accession>
    <name>A0A088RJL8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Metallo-dependent hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_100770</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696800.1">
        <property type="nucleotide sequence ID" value="XM_010698498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJL8"/>
    <dbReference type="GeneID" id="22572814"/>
    <dbReference type="KEGG" id="lpan:LPMP_100770"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100014100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_100770"/>
    <dbReference type="eggNOG" id="KOG1097">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF42">
        <property type="entry name" value="ADENOSINE DEAMINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="66"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN96147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="731" mass="79480" checksum="0EC09AB60272DE38" modified="2014-11-26" version="1">MDSLYHTTVEPVLLRECQQGGEETAAANLTTALHRVPKVDLHCHLNGSVSAPLLAHLERLLIHSGAPASGPDRGNGGGKVGDDEAGHTSFFNSQEKRKHNGLTASPADRTGGAAAATPAELMHRCFTVFEAIYTVMTSLAFTRLAVQDVLFASAAENILAMEIRTSMRDGMRRTFRQDVADEEVTKEMYVDTVTKTVEHLLCGGLVDLATGELLSAEASAHVLAWGKASLKHDCTAKDEASEEGAAAQWWQLYENIYCSLLQPESGASCIQERRRYFLDHILSNLTERMHVRLLLSINRGATEAAAWEAARLTTKTQQRQIMEFHSWCMVHMWRRNGGGTGRDAGIRHSSSLGSRTDASLFSSFLHRRLRQTCWVTGMDLSGNCYKGTYMVLEPALAAARKGGAAVQDSNGTDTSSSDIRVTASITIHAGEKQDPQELHEMVLFAPERWGHLVFTDNTSLSAILAAQQGIELCLTSNLLTGGHSHVVDHHLGGLLQLWESMPESRGGVEEGTNSFPCYVATEAVRLAHREARAMRRCGGPITVSESSETADADSGDTASTFVLPNISFHTDDRGVFGTTLSKELHLASQHPAIGQLCNRLTATVAGVTNGDAASQTPSAATLAHFFWLLERLSLAQVFELPLPVQLLAAALHDSYSCVSEPAAAYEGCALGVLQGAEMGDWRDWESFVRVCNSIAASPVDATTAPSVTPLPSRLSRWEWAWLTKCFDRYYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJN8</accession>
    <name>A0A088RJN8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Axoneme dynein-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_040650</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the inner dynein arm light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="AIN95389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703711.1">
        <property type="nucleotide sequence ID" value="XM_010705409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJN8"/>
    <dbReference type="GeneID" id="22572024"/>
    <dbReference type="KEGG" id="lpan:LPMP_040650"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040015200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_040650"/>
    <dbReference type="eggNOG" id="ENOG502SKP0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273784at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019347">
        <property type="entry name" value="Axonemal_dynein_light_chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13183:SF0">
        <property type="entry name" value="AXONEMAL DYNEIN LIGHT INTERMEDIATE POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13183">
        <property type="entry name" value="AXONEMAL INNER ARM DYNEIN LIGHT CHAIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10211">
        <property type="entry name" value="Ax_dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0243">Dynein</keyword>
    <keyword evidence="3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="167"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="491"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="505"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="524"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN95389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="737" mass="79931" checksum="CF2EBA60C0544641" modified="2014-11-26" version="1">MRAVKTRRAGAIRSVRDVNGNGDVAGKHSDRDALDDAMFQVGLSTVGVEDKCPEDPLAVVFAQDAPLTLTARDDPCVIAHLPLRFKDVLPAVCHQLQFRQRQATHQTCVDADSFSTKDNPLTSPAPPTVDAASHPPPPYQHAHVSDMVVRLLPIAVGQARSCKTALMHPEEDEEDPTAATAAHGPESTDEQQQQQQQSAASTEKRADHEAEDAVQGAPALAPVSEHQLYRTRATEQLLEYFFSSPTPADGADSVDRDEARRSFTVAACLSGMREVPSGTVEYVELLREMVSLEDSLRDAKPDETAVDAVVHLPPYVRDLLVGVSPMESAPAAASLASSGVASGVKNVALRTADGSVAAVERVPVVTTTLRSTLDAVLPPRLFLYYSVHHATAVAVHQRRQAAQHRQAHLRRHQEAHPDDVKGLEEMEALREALAGEYMEAPVGVVLVILERTSDVQAPRDYLLKLEQTLNEVLDMVRARCCGRPLKLIRTSTAHEPAPKQQRHTASAPAASGLSPGTRLKQENASSSSSSMKAASAKGQKAPATTIILATPDKQVCTRTLKPLPAQPAAMSASGGGSATVFSTLNVVELNKERTLVQLSLLGEELIRQVTVDLPERGVLLRRLLDEAQLSIDACAILARERSKATQEHLLDGQDVREATVVQCKVLESEVAELRSRLAYVTARKAALRMWVEEQKARELAVSRERVNFETSLQERLTAHTERVKMAQDAARRSSLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RK00</accession>
    <name>A0A088RK00_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_120090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009381">
        <property type="protein sequence ID" value="AIN96337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696990.1">
        <property type="nucleotide sequence ID" value="XM_010698688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RK00"/>
    <dbReference type="GeneID" id="22573015"/>
    <dbReference type="KEGG" id="lpan:LPMP_120090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_120090"/>
    <dbReference type="eggNOG" id="ENOG502STKU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264109at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="90" mass="10146" checksum="12444E4119AE47B0" modified="2014-11-26" version="1">MDQHYADAAPFQGVWFGTTPTHDFYLTTLEKELLRMSAMEHLHACCLDDPQLPTARDGDTHSLLRSALHESARVFLSLVLLLCLLAHLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RK95</accession>
    <name>A0A088RK95_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_110240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696873.1">
        <property type="nucleotide sequence ID" value="XM_010698571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RK95"/>
    <dbReference type="GeneID" id="22572889"/>
    <dbReference type="KEGG" id="lpan:LPMP_110240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190005500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_110240"/>
    <dbReference type="eggNOG" id="KOG0183">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03755">
        <property type="entry name" value="proteasome_alpha_type_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000004">
        <property type="entry name" value="Proteasome subunit alpha type-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 3 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="5">
        <location>
            <begin position="3"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN96220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="247" mass="27923" checksum="22F11626914F8081" modified="2014-11-26" version="1">MSYDRAITVFSPDGHLFQVEYAQEAVKKGLAAVGVLGRDCVVMAVEKKSAVKLQDSRTIRKIYKVDAHIYLAFAGLSADARVLINKAQLECQRFSLNYEDTMDVDMLVRYVAGVQQKSTQSGGSRPFGVATVIGGFNEDGTPHLWKTDPSGMSSAWRAVAIGRHDQTVIEYMEKNYKDGMLRDECVHFAIKSLLEVVESGSRNIELLVLQHRDERYLTEEELQRFVVEVEKEREEEAAKKKRQAEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKW2</accession>
    <name>A0A088RKW2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_130460</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697128.1">
        <property type="nucleotide sequence ID" value="XM_010698826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKW2"/>
    <dbReference type="GeneID" id="22573156"/>
    <dbReference type="KEGG" id="lpan:LPMP_130460"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130008700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_130460"/>
    <dbReference type="eggNOG" id="KOG3406">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10249311at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000033">
        <property type="entry name" value="40S ribosomal protein S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000530">
        <property type="entry name" value="Ribosomal_eS12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11843">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00972">
        <property type="entry name" value="RIBSOMALS12E"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="5">
        <location>
            <begin position="32"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN96475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="144" mass="15954" checksum="F77E97F4CA01F781" modified="2014-11-26" version="1">MTTMAEETARVEVSAVEENVMNDVTPESLEDAVRIVIQKSLEANGLVRGLSEVARALDCKTAHMCILADDCEDEEYKKLVTALAKQGNIDLINVEERMKLAQWAGLARRDVTGEVTKTLKCSSVAIRDFGERTKALDYLLSQLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKX3</accession>
    <name>A0A088RKX3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Lectin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_130560</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697138.1">
        <property type="nucleotide sequence ID" value="XM_010698836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKX3"/>
    <dbReference type="GeneID" id="22573166"/>
    <dbReference type="KEGG" id="lpan:LPMP_130560"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130009800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_130560"/>
    <dbReference type="eggNOG" id="KOG3839">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10265193at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07308">
        <property type="entry name" value="lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051136">
        <property type="entry name" value="Intracellular_Lectin-GPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005052">
        <property type="entry name" value="Lectin_leg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223:SF28">
        <property type="entry name" value="LECTIN, MANNOSE BINDING 1 LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223">
        <property type="entry name" value="VESICULAR MANNOSE-BINDING LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03388">
        <property type="entry name" value="Lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51328">
        <property type="entry name" value="L_LECTIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="L-type lectin-like" evidence="8">
        <location>
            <begin position="56"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="317"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="321"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="385"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN96485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="424" mass="48169" checksum="C2FB666CC99229C5" modified="2014-11-26" version="1">MPHTYLAGERRSRRCTWWTVGAYAVVLLAIGSGGLLVATADPVPKLTSKQEQRSLNVAIGHHSFAPPLLRQYYGDDDIPHWSIIGSSVITDDYVRLTGDQKGQVGHLWNTEPLDMDAFEIVVGFRVHRPVGGDRADGFGVWVAQPPRFDGAIFGRPPTFSGFGILFDSYDNDKRRDNPMVSLVYNDGSSTKRFDPDKDFMGDSVASCVFDYLDVSPPDMATMRMVYLKGELQLHLSKNSEATETECLRVTKLPLPAGKVHLSFSAQTGDVSGIHDILFVHLSPLMEVKYDHDVQQTMVPPSERHDAQLYNNDAMNNRPITEETQPAPQETQPAPQETQPATQETQPATQETQPSTQPSTDPGLMERQRIEELERKLEELQRRNEDDEDEDEYEDYDDDGHNKRRRVRRVRRTRTPRRNRDRYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RL38</accession>
    <name>A0A088RL38_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_131120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697193.1">
        <property type="nucleotide sequence ID" value="XM_010698891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RL38"/>
    <dbReference type="GeneID" id="22573222"/>
    <dbReference type="KEGG" id="lpan:LPMP_131120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130015900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_131120"/>
    <dbReference type="eggNOG" id="ENOG502SP8W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267757at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="16189" checksum="35C924E9AD80F552" modified="2014-11-26" version="1">MSGLEKSDIISTPMPFPTIPVRGVPQSERSWVENNWWVLLMIECLVLFAVFMALLVYYLFYVRTPGKRLLDDKVDNDGLSHYGSELSSRSSSVELTYISSSTYKRGFAENAVGGTVGGRKSHRPTLEVLPVPNQHSKAAYSPKCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLF1</accession>
    <name>A0A088RLF1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_150080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697386.1">
        <property type="nucleotide sequence ID" value="XM_010699084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLF1"/>
    <dbReference type="GeneID" id="22573424"/>
    <dbReference type="KEGG" id="lpan:LPMP_150080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150005700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_150080"/>
    <dbReference type="eggNOG" id="ENOG502QV2E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277583at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="CDD" id="cd23643">
        <property type="entry name" value="mS23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059199">
        <property type="entry name" value="mS23-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="309"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="321" mass="36834" checksum="032612B56FE7493E" modified="2014-11-26" version="1">MRRSLWRLYKIPKNMGVAPRFDTWNEKYEPWEHLRRMGRLAGTGFYIPPEWYNHFRMFPPINHNFQQERTLNPHNASEPTQDDTEHLSAERIALRDELARKSRLLASEGMRYYNVFWVRKPLDRMEREYYVLKRKGVAHSVAIKRVLQMFYDDLTVKKRVAAIQAEEAKLSGKYISMREAVVLMGVLTQLQKEQLTPHQVTLLVQEQRAKAQTGEAFVATVERSTEAVADAAKGAAEGGEVISADSLADLLSTEAGLDENAPSISYKVTIHDAEHDSVKQLQDAALDHTGRSDWYTGESPVLHMEKPIPTTRTPSSRRTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLJ4</accession>
    <name>A0A088RLJ4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="12">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_140640</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="12"/>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697298.1">
        <property type="nucleotide sequence ID" value="XM_010698996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLJ4"/>
    <dbReference type="GeneID" id="22573331"/>
    <dbReference type="KEGG" id="lpan:LPMP_140640"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140011600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_140640"/>
    <dbReference type="eggNOG" id="KOG3072">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF105">
        <property type="entry name" value="ELONGATION OF FATTY ACIDS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIN96645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="285" mass="32465" checksum="D1142E326F23349F" modified="2014-11-26" version="1">MQWLDNYGDQRYDGHAVQKWLASNVDVCVYIAGAYLAFVFTGPRVMEALFHGKPPVAIIKKAWALWNLALSAFSLYGWLRVAPPLLRHLMKDGMHDTLCTFHEDEFYTTKVGFAMGMFAISKVPEFIDTVFLLMRGVNLSFLSWFHHVTTYLFVWYSYQQGTSIFICAAAMNYFVHSIMYFYFFLSEAGFKSLVKPFAMYITLLQITQMVGGLFVSGYVLLQKFTEGTSNTRTCSGTSISTARTQLVIYIFNFYLFSEMFVKGYVLPRKAPAGEALRTAPSRKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLJ5</accession>
    <name>A0A088RLJ5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_091510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN96064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704386.1">
        <property type="nucleotide sequence ID" value="XM_010706084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLJ5"/>
    <dbReference type="GeneID" id="22572721"/>
    <dbReference type="KEGG" id="lpan:LPMP_091510"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090020500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_091510"/>
    <dbReference type="eggNOG" id="ENOG502S60P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275832at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN96064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="121" mass="13960" checksum="C32FDCA0A9B0C510" modified="2014-11-26" version="1">MKLVRRARKGIRERRMKACINDLNSNLSKVEMRVFRKQKKERDAKRQALGIGEVVPKDVLSGRMNPDLYAVECRLHQEAGLPKPLPYQGYKEDLARSRATTHCVGFVGFRTILHAIRARNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLX6</accession>
    <name>A0A088RLX6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_101000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696822.1">
        <property type="nucleotide sequence ID" value="XM_010698520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLX6"/>
    <dbReference type="GeneID" id="22572837"/>
    <dbReference type="KEGG" id="lpan:LPMP_101000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100016900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_101000"/>
    <dbReference type="eggNOG" id="ENOG502RZY7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270764at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="177" mass="19264" checksum="BFC2689EF415B989" modified="2014-11-26" version="1">MQAVLSQIHKANMKALILSRMNVTMVVLDGIAMLMLIIAWAVTVKKEQGGVMARYAASIIGFILLAITMTLSILVQRLQPRLSLLYAHQMMAVLTLILSSISMGMNDVVVDLCNRGKQVEKTQCGSHIVETIAEVIVALTMVFDYGSSQQRIVTFIDKGILDGIKGRSNAGGMTQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLZ3</accession>
    <name>A0A088RLZ3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Qa-SNARE protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_170340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97072.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697725.1">
        <property type="nucleotide sequence ID" value="XM_010699423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLZ3"/>
    <dbReference type="GeneID" id="22573777"/>
    <dbReference type="KEGG" id="lpan:LPMP_170340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170008700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_170340"/>
    <dbReference type="eggNOG" id="ENOG502QS41">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF26">
        <property type="entry name" value="VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN97072.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="322" mass="35663" checksum="A95333FD5A7CDE1A" modified="2026-01-28" version="2">MTPHDRLHARHEGTEVHCITVGATVITCTRIHRPFQVHHRYATMDAALHHEELLDLEQQVEALLLDMDVPHQQTAAGVGSSSGGGGGRGDVSSSSARAAAFAKAQDILRRLSRLLQHLRVEIRLLDDAERDVYEAHASEHARRIASLRSWAQQRKENAAKRTAAAVSLAQGQHSTGSSSIHFRAVEGGAGILWSPHEGGNDDPDRGDDSATSNRTEAHQTAARISEVQHRILQSLGHSEKLLNETETLGNEAATTLLVQTEQIKRTNAELDEMRSELELVSVELKSFMRRMARDRLIIFFVITIVVCIIVIVILAVLKHKWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RML2</accession>
    <name>A0A088RML2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNaJ chaperone family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_170420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697733.1">
        <property type="nucleotide sequence ID" value="XM_010699431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RML2"/>
    <dbReference type="GeneID" id="22573785"/>
    <dbReference type="KEGG" id="lpan:LPMP_170420"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170009700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_170420"/>
    <dbReference type="eggNOG" id="ENOG502QRZE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000163">
        <property type="entry name" value="Chaperone protein DNAJ, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="117"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN97080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="297" mass="33497" checksum="17683C87163D8516" modified="2014-11-26" version="1">MPAAHFASSCCRSPPLAALSSSYQSTSSLGLLRAAAPVLLCASTTCSSSAWAATRRWQSSSSPSYGTVPADIDSPRGATKPTEEELHREQRRRTHGHAATAEEANKNAVNTHVSGYNPWEVLGLKPGASTQTIRLRYHELMKQVHPDMAVDGAGDIPRLNQINKAYELITKSPTLDRRYRNLVSDTQYFYYKFLPEWMARNVDEMPRYWSWVKWRTPSGFHIFLLLCGFYVLGRFYAAFPLLTSVFFISVALDVLLHTMLAPAALCMLFLYSIMAYRSYDMAWLTSPKGFLRRELGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMR8</accession>
    <name>A0A088RMR8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF155 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_131010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697182.1">
        <property type="nucleotide sequence ID" value="XM_010698880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMR8"/>
    <dbReference type="GeneID" id="22573211"/>
    <dbReference type="KEGG" id="lpan:LPMP_131010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130014700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_131010"/>
    <dbReference type="eggNOG" id="KOG2861">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18302at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF1">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="561"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="DUF155" evidence="4">
        <location>
            <begin position="339"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="246"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN96529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="591" mass="65361" checksum="7E96E11224CF1DA4" modified="2014-11-26" version="1">MDSETESSSKLNRQLVELMRPLGCRTTLRVSQVASILGVEGEEQYQHLLDLLARSHFLQYDAEKQTVRPLLELKNLEDDDEAALLALSDVDVVGGDVRGRRVDVSPLLGRHRQHRSNSRHSYRVGGSNAAASGYWSDSGLANTTCSVTLLSRRRAGGTWTKPGRAGLEDAASYPGPVGRVGYLCVADELHLGKLEAYYRAQGYYTKFDFDVLHVRFAQSSFVNVGANAGDIANTLVGLRDRQRSRYATATQQVGNDATQSVDTASSPSPPPLLEQRGTASPAENSGVSAFASSHGYGAMGSNARNGGALTSTFAQGGEGGEAPAATSSSGSSTMHYFDLFVFPYGAVVWWGFDQRYFKIVENDYMLPHSAIAHCMTNRYTTKLVNENYPVWCTFNLVARDTLEVDDNFKARLRFDHFVIPYRRGEVATGSVLMLCASHALAQSAKIDYIELQVQGLADSCSPLPRELREKGAVSITERRLLQLRGEVLSYRLMLKSGSDLLDQPDFFWENSYLKPVFQATKEEYEISERVEALDNKLDAANEILSMLAEDFSQRHGARLEWIVIWLVFVEVVIGVLGLLIDVRPWLQSNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNB6</accession>
    <name>A0A088RNB6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_200650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698264.1">
        <property type="nucleotide sequence ID" value="XM_010699962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNB6"/>
    <dbReference type="GeneID" id="22574272"/>
    <dbReference type="KEGG" id="lpan:LPMP_200650"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200010700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_200650"/>
    <dbReference type="eggNOG" id="ENOG502S1AH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="248885at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF63">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="259"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="461"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="663"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="83"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="265"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="490"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="663"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="677"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="787" mass="89581" checksum="90193628466C84AD" modified="2014-11-26" version="1">MQTKEKEFDEKIHQIHHTFQNAGEQLVVRDHIISHLKEELTGLRAEAARIPKEYQAREEKLLLRVEAMMTELSEEQNRAHHSRRTAEEEVRAVRDSLQTTEQQLAQQQRMSDDLLRQLRASDKVLQEEKKRHTAALAECRSTYETKLNELQRTFRTMEKQVAKSQSRLEDMEKDRCQQQAKLLELELSGRRRISSETIKAKELLAENEALREEVEAVRLSMARLLRLMSEVPTMSDYLRWNELSSEFVFLGYPTRYFGTSHRGRGTSSPSPNWRTGSRGTSPRQQQQQRSPARHRATAVAAGDDISFDKPGPSSHSSGCYQDANVSGISAGDTGVEDGVYAGVAASLSKNVWLNGRWAQEMISIIAAENNFTRLKRIKLLELEEAAQLSEQLPSARDVLECRQPEHHYWIPYAVFMEAQTFKNKYYPKLPAMSHFSPFLIQLNKIWRSKLQDRLRVMQQQQQLSQARRRATDENRFASRTRTRERDVGDQGSSSVSRLTSRCTVASMPNPGELFSEWARQEARVDDIHAEHHRLRREVRLHVSSQKSLQLFRLYDELVRGAHQTLSEVLRLAEDLYDSASAQRVSESEERKRTAASTLREIQQQAQTSAEMADLAAARDRLVSVVDHTCQQVCNVGDSLSTRMMSYYSDLHQLIHMLHHHIRQARERSHHKMREQASSDGTGSISSASSSTAPWSRAAVNTVLSTEELHKQLREALLVQYGTPRGTGADADHAAAAPSAISSDALLKLAASILDFAEEIRREVTQAATALRVVTKQAMRDTKQFQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNM7</accession>
    <name>A0A088RNM7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_200610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698260.1">
        <property type="nucleotide sequence ID" value="XM_010699958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNM7"/>
    <dbReference type="GeneID" id="22574268"/>
    <dbReference type="KEGG" id="lpan:LPMP_200610"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200010400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_200610"/>
    <dbReference type="eggNOG" id="ENOG502RXHK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="206339at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="591"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="652"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="796"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="658"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="709"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="750"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="858" mass="92849" checksum="A6F25FFAB9C68F98" modified="2014-11-26" version="1">MSASSREPAASRAQGMQGSTPATPGGGKLGTLSVSELRTAMQQHLRSTGALRELKTQLRGMVLAELLQHPKTARMLVHGASQSVPPSPGEGQARLEDRKPSATGFPGTPAIAVVSGRTDQTLQTWSCGLADALVENHLRRTRRPMSLSIFSTEAEVPPFSASGAPSEEEQYLAHFFRQIGTGATANPEDDILTPSPSRSAKSVLQRLVEDCVARQGLASTAEATRHLHSCSTQTEAADSADGAANSLNSLECRLAAVDAKYALTFAQLKRTTGTGEQPFFLRSEVERRLQQYKNDMHAQLRSEYEQKYNNFTRVKLQEARDEADGRYRVFVQNKTEELAEMERSVLVKLEQERQRLKMAWEAVHQQRTELERRQRDTMKQLADYDAAKQRSDEELYSYKESTRALQLQCAKWEELCGTRLMELDGARSREGRRVEDIRRLQAEHAAELQLKEEEIGRLRYRLRLISRENNYSLPAEAAASDHLKDRTDSSAVPLEHSRTAAAPVDPQQLYGLLTRAEEMQRNAVVQQQERWDAAWLAAALSNNARQPHTHAPATVPPVPVTTATETPERVFAKPSSSPSALMLQTSLYPLQSGKGQAAQQPDHRSESPESRVATASAPVATIPSVSASAADLATSLPSSPKVNSPEPTAIAAVAKPPSTSSDKAQQSSTSSTRSATTRASLAPPSSSVSSTRATSPKLKNVPVVGAPATESSTSSSTRQSLSSPGVPFNASTTPVQPSVHHADDDESENRSAAAARLNAVAAEEQSARGEVQSEEASARGSITWLEGNRRELLVGELKRARSEEDGSTSGSGNGVAPRWKQFGGGEGGGSAADLGFSESFSSDDEALIHDSDVDDSEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNU8</accession>
    <name>A0A088RNU8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Selenocysteine-specific elongation factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_202570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97752.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698459.1">
        <property type="nucleotide sequence ID" value="XM_010700157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNU8"/>
    <dbReference type="GeneID" id="22574466"/>
    <dbReference type="KEGG" id="lpan:LPMP_202570"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200031500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_202570"/>
    <dbReference type="eggNOG" id="KOG0461">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2067at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001514">
        <property type="term" value="P:selenocysteine incorporation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04094">
        <property type="entry name" value="eSelB_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01889">
        <property type="entry name" value="SelB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03696">
        <property type="entry name" value="SelB_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000052">
        <property type="entry name" value="Selenocysteine-specific elongation factor EF-Sec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049393">
        <property type="entry name" value="eEFSec_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF11">
        <property type="entry name" value="SELENOCYSTEINE-SPECIFIC ELONGATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21208">
        <property type="entry name" value="euk_SelB_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97752.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="679" mass="72656" checksum="D75717A5E0441B34" modified="2026-01-28" version="2">MLNVNIGLLGHVDSGKTALAKALSRTASTAAFDKSPQSQSRGITLDLGFSACEVSVEDGNEDACEVLRSAELTKVQCTLVDCPGHASLIRTVVGGAQIIDAMVLVIDATKGMQAQTAECLVLGEVMAKPLVVVLNKVDAVQGATPEAKAATLAALKQRLQQTFRRTRWPTVVIVEVAAAPREVMGMIGPPVNTEAVLPQVLRVVDLVALKAAKEREGERPERFYMLVDHCFAVRGQGTVFTGTVVAGMVQVGDTVLVPELQMTRKVKGLQVFHKPVGLARSGDRVGLCVAQFDPTRMERGVLCSAASSGRTLANSSQLIAKVHRVRYHPLPCDTHTKFHISIGHATVMGTMRYFSRPARTNANLNVSGAADRFDPFIESTWVEELGDEVVVSYNTSTSSTASAPGRPLLPAPAEQDYYAVLLLERPVLAASGVFMIAMRLDVERENFCRIALAGTVCHVFSKDSTAVTAATPTLGDSEHSSNHTQVPAWRRLPVVRYRYRTLRVNRVLDSRSCIATGVVSLQTPGDGGGSATPARAFSSAKRNKDSVNGEERQKADLFAEVQKFLRLVVVFEPEDADASVTTPQTSNLGTVKGIIDSSFGKTGKVKLIFDGPVFADPAANTTTAPTGAVLAVTSNRRKKSATDPSAEDGSNSGGVFLRPGRILLILKKYPFALHSGLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RP45</accession>
    <name>A0A088RP45_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin-protein ligase, putative</fullName>
            <ecNumber evidence="6">6.3.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_203730</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.2.-" evidence="6"/>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698574.1">
        <property type="nucleotide sequence ID" value="XM_010700272.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22574584"/>
    <dbReference type="KEGG" id="lpan:LPMP_203730"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200043400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_203730"/>
    <dbReference type="eggNOG" id="KOG0170">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271273at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000036">
        <property type="entry name" value="Ubiquitin-protein ligase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045322">
        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670:SF15">
        <property type="entry name" value="LIGASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="5">
        <location>
            <begin position="1029"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="234"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="1335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN97867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1368" mass="150148" checksum="36C68248FFB08479" modified="2014-11-26" version="1">MVSPSDEAARQADEETYTSLLEICTELVIAEGSDDPPLKQPLGMLHELLHCQHLGGDATVLSVRAVRILLEKFISSLSSKLRAKLAECVRSALKRVTRIMYGSSRSDAHFEFVHTKRWELQEELLQCMSAAAQSDKAVQAALPPPQEQLNFCRSVMDVSLDMCLQALRMCCVLLRSTQLSSQPHLTALIRDLFRSRFVALESMEMNHDWLRLLRHLTEGAVTLRAYAVKTSETMKVNSPAGEEKTRKRKRSTASNSAQAAPGSVAGVDRGRSEGPDEALVLLHLCQRVCATPNLDRDFRSTVFSCANAILSDASCLASVSADTCVAVAMDLARELTRSVRTTLTITNPFVSREVVPGPNGAATTSLLGTRDEEGEDDERQGEDLLRNGEGAKWHLPEPEWPLLILIANLFAAKTVPTPEHLWWSVGDDEYARRFSKEDCLRLTKGFFAAQDVLDLKKRGSCVHLSTMRELLWPFDLGCRVLFQPVPCAYAAAASMPVVPSLQCPASRACELAFALRRHDVAALLEHLGATSHNGGDVATYGQSVLLQVLLVAGPHAKSATSAALCSFLANSVTPLIEQVSEALVRHDRAWAGTLLDAGVTERILQRSASGTPERSPVVQMLRREAASLPSTPLLLPRGGVPKVGPEELRHVLQRGGRSDVEELLETLAFSEACAWDTAECRETVYNFTDVSVVGRDSTDQTNGVAPAGWVRQLEQLLTGLVVKRLQDMALQLQQSKTLRQILEEGEMVEVTLCDSGRSGKFTCPQQHSLHHHHGCNWKCDGCGASDLHDAWSCRECDYDLCATCARTHCNRANGSLTATAQDILAAWHALGGKSTDTSVSRTRAVLFTEEMGLVPAAMPIASLQRQIVHLGDIYTPCPCGLVCPGPSIALGAAASTDASLLGALISVFGRACGQDLGVQRCLLKVYESAGAFVFLGGARAVPAELRCLTTHLAPHLPLSVKHLITRYVAIDCRRFAFQALYDRSAMVFTNSGVGLESSKEHKVQVPRNDKPRLLRVLHDRLCGLPTLLLKVDFTFEGEEGFGSGPSQEVYTELSVYFRTEPKFWFMTEDDGGADPVMLAFPTTKALFLKEFFALGAACARSFIDDYRMNMDLLPQAWPLLMLPSLGLPLHQNAGKCTSLSASTAAALRNLLEVLDPALHRSFAQLRRISETELAAAELEMNDGTPLRTHADLEKHMQYTMITRLEVALENLRYFQWGLLSVMEVEALWCLSDEERSVLLCGADAKGNRPLFTEEELRAQTTVGSGYSSGSIHVEMLLSIVGGDFTRSQQHDFLEFLTGSPRLPFNGLAGLGRLITVAMKEMESTREQTLPSCNTCFLYLKLPPYSTREIMKERLLLAVTEGRRNYSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RP54</accession>
    <name>A0A088RP54_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_203830</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7"/>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698584.1">
        <property type="nucleotide sequence ID" value="XM_010700282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RP54"/>
    <dbReference type="GeneID" id="22574594"/>
    <dbReference type="KEGG" id="lpan:LPMP_203830"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200044400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_203830"/>
    <dbReference type="eggNOG" id="KOG1863">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF888">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="6"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN97877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="903" mass="102424" checksum="241F6CDD1E8C8F5C" modified="2014-11-26" version="1">MRSGYVGIYNQGSTCYLNSVIQALYHIPAFRRQIYNLPAVQEDSVALALRDVFAQLEVRNRNTTTTELTKAFGWSAQEAAVQHDVHELMQQLFDSLETTLKETPQRNMIRDMFGGLMVYRSRAVDGAEYLSDRLEDFYDVELVVQNKANIEESLREFSSGERIEGVCVELTPGADATPHTIERSQHFLDCPKVLLVHPNRVAFDMETYELVTLRNVWSFDVNLSLSNYVVGDASLKLDKESQEKWKTISHRTHLGASYSLRSILTHAGDATIGHYYVYVNFDGEWVRFNDEVVESATEEDVHKSAFGGQSIQSRYRLFDNERASLLIYVNDDVKEELLHETPPPSAIVEVGRCIEEERTRKEETRKVNYYVCDKSVVDVFDGVHGAPDKLQRQMSVRLSPGQDEMAAIITAAAKELQVTPAQIRIFYRDRHGLSPWSAVETSNSYDSYYYPPIFVDVAPPEAQDDVAPATAATAEPFIAFLRKIESQHDRDVPVAIVHSIPELQALVPHDSIVYESRGGPQYLSAITATNQLVCGANLLYTHQRSSMDAVRGYLQHRQLVCTKVYLYDDYTAEQTELFDLHIAESTPYSTLQMGLYKMMTESSKSLPTPPSHNYLGFFKGNDRCNYAFAMPMASSLTIQWNTYNHTLRDVWGSVQHEHKIVMTVLPMPLEKIDLTVLVTLNGGYNNLPRVYIPRECGSITFHELLELMLEQLSTRLRASAVAGYKQQLAGKARLLRLLRVRRGELLDVVEQLDTLIDLESREDIVLDKLSPAIPGHELVNVLFCRRRSGEYYFGLPTNICVNSSLEEQGDVLLRRIIKKLRYPDEEEAMKKWILCVMNARSRKTRTASKKEVLGDLVKEVGGAPFVLVVDRPQCLRLDGIEEEGHRTESIVIKSTSKTDLSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPD8</accession>
    <name>A0A088RPD8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_203280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698530.1">
        <property type="nucleotide sequence ID" value="XM_010700228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPD8"/>
    <dbReference type="GeneID" id="22574539"/>
    <dbReference type="KEGG" id="lpan:LPMP_203280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200039200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_203280"/>
    <dbReference type="eggNOG" id="ENOG502RSJN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268013at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="232"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="349"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="688"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="827"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="942"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="564"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="648"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="368"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="394"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="717"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="828"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="840"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="902"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="971"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1031"/>
            <end position="1040"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1049" mass="113957" checksum="5BC4B7FA2EAE1C78" modified="2014-11-26" version="1">MSAVTDTQRCGFRLVLTCVYLIVLLGISPRSSPTLVTAEDVLARDDFVPLPEGAQQVELDLAMPVPVPEYLHSVGPSDPLKEAVVEVSVDIPLGDAVFTKHGVPEVQLAHEAAAAAAEEQKVIEMTRMSEEILNVEEARRAVQAEREEEVVRQTECAVPTADRHCEEKERTATEAWSAAEVDASQKVLEKVISYKVAMGEDSLPSAARSLTEGNDPDPLDSGALHATDHVQDTAVHHSRQSPLPVDPPMEAEPSPSPVATTTDTNPYTEEKVNAPIVEEIQRTEEVRIAVEVRQEDKARYPEEMYRKAEESKLLEETKSAQQVQKVEQVRINEETTRQAEAAQHAEVATQAEAAWSAEEVTRQTEAARQVEEVARSAEEALERAAGEGALQAEEAPKAAEERRAEEGRKTDEERLTEEARQAEEHLKAKEARLAQEAQRAEETRLAEEARLAEARRLDAEAQKAEEEARRAETMGRAEERRAEVKLKGYAVAESAAQLRKETAGAQERLTAERKEVLTKIDEERARFQAATADLTKQQEQEKSSAAQHAKVIVTELQMSMGKRLEALQQDLLTLRRASVTLQSRVSALLESNKPLAQVQEDVQVLDEEVRKAAETFDNIRGAADSVTDTARAAVGSQSDASAATSEKITLLTEQKRALETARDAAIQELLGRLQTLDVQLSEVAKQTGTQVAAVAEPSKTSESAAITPRWPVAPPTAKTSQEATSPPSEAPRPEETAKPASAFFAPLAEPRTNPSKDTEKSRGGYRCKLIETLGKWAEEKGYNKSSYEVHPHEDGAPYQMKGYMQIVGTVVVITIAASIQTLRWCRSGGREEEKDGESPKTVTSELQSTETSSALQPKPLSQSGGPSPQGLQTSPPSISIPRGTNVALDRGDRESSSHWEGGSTSLSSQRGTLSAVSEQVRLSLGEGRTVSRIPMRRNHLDAFPPGTPVSGISGATLGPPCGGSPLDTARAPPLSSAASPFTVPRREALGVSSSSKQWPRPLAGGPLGGPPSLPLSRHLPIAGTSPQMQRRQNDGDEFDLHNPFLSRWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPN4</accession>
    <name>A0A088RPN4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_171310</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697822.1">
        <property type="nucleotide sequence ID" value="XM_010699520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPN4"/>
    <dbReference type="GeneID" id="22573874"/>
    <dbReference type="KEGG" id="lpan:LPMP_171310"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170019300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_171310"/>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF25">
        <property type="entry name" value="CYTOCHROME B5 HEME-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="7">
        <location>
            <begin position="142"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN97169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="219" mass="23772" checksum="354A06D4013186B2" modified="2014-11-26" version="1">MAKTSSPLASSSLGASPHRTKTSLKQTRLVSFFSCLRCRALAEHHSNGRALAIFLLLIVIACAALSNCGIRNFSFVQRPIAPSERPGREVPKAARESASPFITTATPGIALHSDPRDAAAEKAMRYAEKFYETAGRLRCPQPQRYTQEEVAQHKTQEDLWITVDGNVLNVSAFLPQHPGGDVLLDGAGGQDMATVFASFHNPSSVRLLANFCIGRILLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPT3</accession>
    <name>A0A088RPT3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_204860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698685.1">
        <property type="nucleotide sequence ID" value="XM_010700383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPT3"/>
    <dbReference type="GeneID" id="22574698"/>
    <dbReference type="KEGG" id="lpan:LPMP_204860"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200055400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_204860"/>
    <dbReference type="eggNOG" id="ENOG502SMAD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267254at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="654"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="746"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="812"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1131"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="746"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1141"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1161"/>
            <end position="1171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1189" mass="125597" checksum="0E86E5280284D9A2" modified="2014-11-26" version="1">MQIPRQTLAPLNVNGAPLSYDTYSAALQITGGGGRAEGSPRASKHLQVSRNGHHPYKHDTLQPSSSSSPSTAAVHVRTVGEQQGDHSGKEHLSLSVGVALHTDAVLAPSDEHVGVNSRTPHVPAPHGNIASSALATCAAPSPHSTRCIEIADVNPQPSVMGATHVSEVAAHSPPSNKPNAPSRRSSIARLREQVKAQQKGKEAAQPANATALTLVCDSNAAATARQGAAVQRGESIEQQLLYSYRPALPSTCLTSSPSPTSAEVTALNRRGIAAEALAMPATLSVGTAKVLPNGLRSPSAITDVGAAPLDYSGLDNEATGLVNNVSPSLHHHEQQQQQCSASLSKRRTADVARGQVGCASQANAPFQALQFLSLAPINTIASPPLSSRSGEPHHLHSPHQRHNLRAGGEEGGNANFLPDSGKDREFYDAAPLRTRSAHTAKAVADGNPIISSSVVSDCDLPSLVVSPFAFMACCAEGTHRSAELHKGFTLHQHLMAVTKYLQWMRGRQQELEQLVSGLQLQVHTQALTLRKAREELVRAQQRPAANPSVLISSQRSMLNSCLDFVSTAASGSKAQYPHDACKALPRDVSIREPLVMDYEDGDGVGRDAREDYAGSDSRARCTRPSHGTQTQRGGSDRNGIRHYARQLRMCASAGQQQPDMANAQSSTSISPTPVRCEQRLVTSAGTATANQTKTAAGVQRRGEKMQTAILGQPKQREEQQGITNCDAHALSGTPQRCRLHRNSLEDVSGVSGDGQVQGNTDGAKGTRFRTSSVPRLSGADTATERGGSLVRHGKSLASSYMHYYSYSRQQPGAAGSAEVSGMSNVPPYQPPNESMSPISSASLDLNDHEDDTDAGHMRQQLFDLTATEISVPPRADGIYFTCRVDQPGADAEVKADLQTSPAASPRSAPSLVSVTYRPSELARTDGGNAAEAVSFTDRVASTRGGASPLDARNPQVHAGNTSVPLLAGGVRLAASLQRPTLVRKSDIAPLTPTVRNCVDEHKVVLPTVTPPSLTALASVSAPSATSNIPSKSDVGQKRHITVPTLSGINLDAPSSHLGVRTSLVVAAPSGSLSVNHSGVHASYDGISMAAPLLKPVAKRSSASMHHPVHMYGYRNANNTIEGRRSGFVRSADYLPDVPGKSGRHRSRSKTRRSTAMRLPSHATSILSPQETADQGVVVPRLGLSPWREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQ00</accession>
    <name>A0A088RQ00_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_205570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN98048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698755.1">
        <property type="nucleotide sequence ID" value="XM_010700453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQ00"/>
    <dbReference type="GeneID" id="22574769"/>
    <dbReference type="KEGG" id="lpan:LPMP_205570"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200062800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_205570"/>
    <dbReference type="eggNOG" id="ENOG502SIJ6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267736at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="315" mass="34067" checksum="6C337AC78A902418" modified="2014-11-26" version="1">MLSPVQLRHQLRVAAAVTQRLHQRSQRLEKEVDAWKHKYAGLEAKTAAEMREVGIDEGKLTERQTFSASLPDGTHPHQSIVAPSSLTAAVAATASALAATQSLEVTEARSRQLETEVKRLTAHKQELTKRLYVAEQTVGALKEKLRIMAAISPATSSAASSPLGVAKTTAGESASDKSRSKALESGATTTPTRAPPSPSGTATKSEMVDPCSDGTVCVDGADGESFACLRSTVRELQRRLDLSEARVEQAEQIHLDALLLHRESTPSAVALVNAEVQKLFQLMQQQLLSNAVQQQAERARMSELLYQLQCQQRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQQ4</accession>
    <name>A0A088RQQ4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="2">1.11.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_230050</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="2"/>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699164.1">
        <property type="nucleotide sequence ID" value="XM_010700862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQQ4"/>
    <dbReference type="GeneID" id="22575209"/>
    <dbReference type="KEGG" id="lpan:LPMP_230050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230005300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_230050"/>
    <dbReference type="eggNOG" id="KOG0852">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="185659at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03015">
        <property type="entry name" value="PRX_Typ2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000003">
        <property type="entry name" value="Peroxiredoxin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF177">
        <property type="entry name" value="TRYPAREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="36"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="10">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN98457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="226" mass="25300" checksum="6C62AD4285CF4BCE" modified="2014-11-26" version="1">MLRRLATKCFQRNVQCRGFAATSPVLNMDYQMYRTATVRDPAPQFSGKAVVGGAIKEINSNDYKGKYIVLFFYPMDFTFVCPTEIIAFSDRYLEFEKLNTQVIAVSCDSEYSHLAWVNTPRKKGGLGEMKIPVLADKSMEIARDYGVLIESAGIALRGLFVIDKSGILRHSTINDLPVGRNVDEVLRVVEAFQYADQNGDAIPCGWTPGKPTLDTKKAGEFFEKNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRE0</accession>
    <name>A0A088RRE0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_202880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698491.1">
        <property type="nucleotide sequence ID" value="XM_010700189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRE0"/>
    <dbReference type="GeneID" id="22574498"/>
    <dbReference type="KEGG" id="lpan:LPMP_202880"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200034100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_202880"/>
    <dbReference type="eggNOG" id="ENOG502SJV9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273606at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="403" mass="43470" checksum="BB357F66312B9AF8" modified="2014-11-26" version="1">MTAVPTALWIARFSEWSAAPKYLKSKMLQEAEQLTVYMQEKAARHLAKAAAAPTDLSKSCQLRDGGTISKCTTGTTVRVASLVGNERCTHGVEVLATASRHGNESLHRCSAAAQENEMDAATPTTKSQQQQQQQQQQQLAVRTASSPSNFFVGRKQTRNVSGVMGSGPEAPAAQEHGGVVAGVCFAHSASQQQQHSRGSEALSQNAAPPPLRDSALQRPSCDATRYSLVTYSETIDDKLNDALLHLENCGNEVGEALVKRRDKAALLLGVMDEELSGTRRSSSEVMESTSQRTGLDNGEEQRGNVEGKKVTSTQGSKRRREQAGCSGLPASSGGHRVCREGGEAHYLSQRSTPKSIRGGGLLPLLRDDAQHAPPPPHLTRADIRRPHSHQPPQEDSQVVYFDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRE5</accession>
    <name>A0A088RRE5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase, putative</fullName>
            <ecNumber evidence="4">1.6.5.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_231030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.6.5.5" evidence="4"/>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699260.1">
        <property type="nucleotide sequence ID" value="XM_010700958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRE5"/>
    <dbReference type="GeneID" id="22575308"/>
    <dbReference type="KEGG" id="lpan:LPMP_231030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230017000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_231030"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003960">
        <property type="term" value="F:quinone reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05276">
        <property type="entry name" value="p53_inducible_oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014189">
        <property type="entry name" value="Quinone_OxRdtase_PIG3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF18">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="11"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN98553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="340" mass="36608" checksum="B0FD5C9689B53271" modified="2014-11-26" version="1">MMRAVVLKGFGGADMMTLGEVPKAAVKKGTDVLIKVMAAGVNRAGVSQWRDRYELPDGANSLLGLEVAGIVEQVGSDVVGRVKEGDRVMALLPGGGYADYAVAHMGCVMAMPQGYTFTEAAAIPEAFITAWQILNRHGKVKARQRVLIHAGASCIGSASAQITEKYFRATAITTSPEEKLGECKAYASVALSHARDELGWAFAPKVKCLFGEESVNVIVDSVFGGTYLTENAQVLAPNGHLIVIAFMGGALVRVNALPLFREKAQIAFSKLHCRSDQYKMELVTSFEREIVPYMSERIISTIVSRTFPLEEAASAHKFVEENGDYGKVVLTVCEPSKAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRF6</accession>
    <name>A0A088RRF6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_240280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIM50 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98662.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699369.1">
        <property type="nucleotide sequence ID" value="XM_010701067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRF6"/>
    <dbReference type="GeneID" id="22575437"/>
    <dbReference type="KEGG" id="lpan:LPMP_240280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240007900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_240280"/>
    <dbReference type="eggNOG" id="KOG1605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000159">
        <property type="entry name" value="TFIIF-stimulated CTD phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98662.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="385" mass="42650" checksum="43FEE15F3E50559C" modified="2026-01-28" version="2">MAASLRSRAGSCSPDGLPLASSPSPLSTITRVWNDRLRALSSPRDVSTVGELDNVIDATPTVKGEGRLRQVAVISSGGGRLEAASGVDDGLTDSPAATVRTRTSSLYAARTSSKRRALLKWKDATAVSPRSSSVITARHPVDPNAEVVVNFAKPLFPNTLLTEAQDEKRLLTLVLDLDETLVSNRDSRHSSAVLRPYCLHVLNALRHMKELEIVLWTASTKETASPVVQQLHKTGIIFDDTIYRNNIWFTQPIHTKDLRLLGRNMDRVLIVDNSVGCCKLHPRNSLLVEDFHGVRRRDDAALVNVYYVVDALLRMMRERSMSVSDGLGCLIAEGQLCHMVNYDLPELFKYIPLTEVPELKRPPVGRFVRANTAPPNTSIMQHWVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RS34</accession>
    <name>A0A088RS34_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_241400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699480.1">
        <property type="nucleotide sequence ID" value="XM_010701178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RS34"/>
    <dbReference type="GeneID" id="22575549"/>
    <dbReference type="KEGG" id="lpan:LPMP_241400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240020600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_241400"/>
    <dbReference type="eggNOG" id="ENOG502SI0G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267980at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="593"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="738"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="868"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="536"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="614"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="757"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="875"/>
            <end position="891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="914" mass="94862" checksum="7DD3E4978D453FA3" modified="2014-11-26" version="1">MSIGADEGQPVLAVRQFRLRDGQDTDSSDSEDGVGWPASRWRGGASAAATAGSRLADVLQRPSSLTATVAPSALHPPRAGSSSSLELFTSSSRSSSPARSALPPDFRKPMAAAAITTTQKGVLSEKMSRSTTSSGSNTHPPRHDMDSRKHGDSDTAQTRQYVQSAGSPVRALCTSTATCSTMEEERQTMPGETIAGYAAVVVAVASAPSPTASNTPALCSDAVQPRSAATGFFERIEASPPKAVDAGFTTSFTSFSAGAAAGKSQAAVSTTAMAALRGPASPSATAPSLPGTTSMRSTIIDATPTVAAAVVPVYTGGPSEVRQEPLQTKVGVVVSPMRFPKVPLAASSSSSSSDDAATLLAPVRVARSASAGYRTGDVDTAIPGQSIRKLTVPLTTAAVADTSTSSASPQQPPPSTTQSFVAAAARQTVTPTAVSTAAPHDGSSASGSGCPVLSGPGGVMYNRVSAQGRGFVPSSVLEAPSRPRWRTLHSEHTASRSFLATVLQPVVIPAAPSSPPGSTLSTQAACAAEPLSAAAHASSFSTSPPSVNLPARPQRQAPRLPGAIRTSAVLSLIEDDDAERQCSSFSATSALLKERSRVDTGQPKTVDVQRRGPPSSPSASPPLPPPLAISLSPVQRAVSSVDRAASPLVSRSAALTAAQRQWEAALVIYDDRVPPAKRRAKNQSLAVTGKTAALAFADPVSAYLLRGLRKVASQEGKRENLLTCRPVLRIGGGAAMRRNHTSGFSEQHPLDGRVVNDDDDYEAADDSDGATRGSRDNYTALYGSTDLLTGHRQYPGWSSADDRSARVTRHSTSNHTVQHLFSEARQQQRKVDVDFWMSGTGNGGSMSYVMMHLERQGARTARVLKATHSDVSSGALPPATLPTTAASRTTAVSPRTDEAVSVDLLNYRHSRRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSC7</accession>
    <name>A0A088RSC7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_241630</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699502.1">
        <property type="nucleotide sequence ID" value="XM_010701200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSC7"/>
    <dbReference type="GeneID" id="22575572"/>
    <dbReference type="KEGG" id="lpan:LPMP_241630"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240023600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_241630"/>
    <dbReference type="eggNOG" id="ENOG502RX7U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270651at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.10:FF:000053">
        <property type="entry name" value="SpoU rRNA Methylase family, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051259">
        <property type="entry name" value="rRNA_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43191">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43191:SF14">
        <property type="entry name" value="TRNA_RRNA METHYLTRANSFERASE SPOU TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="tRNA/rRNA methyltransferase SpoU type" evidence="4">
        <location>
            <begin position="282"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="14"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="491"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN98795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="517" mass="54831" checksum="A9C7C385D47B289E" modified="2014-11-26" version="1">MFGLSRCCLRYAPRRPPGFGAVAGGGSRPHRTGAPAPRQYDERAAASAETAEAEVVAASTSTWENAKRAAADLPGRAQISPPQPKPYRAAASTVSPPQQLRVLAKPVVLKDVQDIYAVTPTQEVRGQQLWAATKALRSNKLVRKVNAACVVGGASAIQRIWRTYKIRPNVVYVPNTTSVVPAWCLEEELPTVIVRCSPVAVKRHLLSAEYSDGYAAEFPLPVNCVTEATALLAPPPKSAQSETAVPSTSDALPSLSEKPSATVPQVARPLDNAFSHHALEAMLVLVGLRIPSNVGTLLRAAADMGYDAVVLVNCADPTQEKVLRASDGTVLSPALRIYETETTEQACVSLLSSIAAQHYLMPFLAVPSQEVEPAFEVAKRFHVYNARNKEAAASPVSRGAAAGHSDDLSAPSPPQLGAMVILGSEARGLRDLNGKWGVPYQLVTLPLPNPMVDSFNVSVAGSVLMHLFRPSAVSHFTRLVALSGEAVGDLLPTPVADDDESDEHEGVDGEDAEASGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSJ5</accession>
    <name>A0A088RSJ5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tubulin epsilon and delta complex protein 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_210830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698871.1">
        <property type="nucleotide sequence ID" value="XM_010700569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSJ5"/>
    <dbReference type="GeneID" id="22574905"/>
    <dbReference type="KEGG" id="lpan:LPMP_210830"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210012900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_210830"/>
    <dbReference type="eggNOG" id="ENOG502RY2Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="252922at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839046" description="Tubulin epsilon and delta complex protein 1 domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="633"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="790" mass="86818" checksum="469402586100A36E" modified="2014-11-26" version="1">MHIAVRVWAALGFFEIRSVEGVGLDEGEEAEEMSHCATVPSSPEDVESFLWGLKEYLSFYCADLPGPSAAVLVDVTVLLRNGLWRVLFNAVFYCLTVLDKHRRRRGPLSPREADVRTGGAEDTYEVVYSSSSDADDENAGEVSLSRAAPVRLVWRHPGESEEEHLARCVRDPLPLNSPLWSASSFTPCGREADSAGMMCSDHHDIQRPSSRFPLDEVYSGRLRTALPIADWYLVLRCLAQVGYRRDAFYLQTPFNASPHELLLALLWLTQQYKMLAVAEYVELNRRYPFLLQYHVNDAFLYGSVAVGGTPQPAHITARERLLYGLSHASAWPPVSFDENATIAVRLAQLERCLGKAASSAVPAASAQATALTGPSAASLHVRRLMAVRRLLSLSFNRLLQALQRQAEQVTLLGLHSPLDAQLCRKEHHALYEEVTAGLAYVQATQQRLQTTADNLAKAGSLVAFLLRYEESTVSAEEVLLGLEEDDTTWLSHDNPAERDASSTEATPVRGKRKATEADRWRRAVRRAKLPVSQSASESAPASLATSAASLAQAISTFRATHVRATLTETWRRLLRRGHAAPQTVPPESLRFLLDAEAQQVQEASVRENMKSRYSLQAALAAELAVLVYQAQQRRHRSQSHSPLRGGDSGALRAANSATETRTVDGSVGLKVRPVQVALPPLDLVTHASAAFAQLRSEEAIYGSVTLGSAELQLTEVGEPAAGSTTSARLELERLKAWEEQLNVQLGVPAQTTASIKYCKEVLQALYHQYGLRIATPVAQKHFSQILASVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSM2</accession>
    <name>A0A088RSM2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L9, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_211250</name>
        <name evidence="6" type="ORF">LPMP_303310</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698911.1">
        <property type="nucleotide sequence ID" value="XM_010700609.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701353.1">
        <property type="nucleotide sequence ID" value="XM_010703051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSM2"/>
    <dbReference type="GeneID" id="22574947"/>
    <dbReference type="GeneID" id="22577384"/>
    <dbReference type="KEGG" id="lpan:LPMP_211250"/>
    <dbReference type="KEGG" id="lpan:LPMP_303310"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210016700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_211250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_303310"/>
    <dbReference type="eggNOG" id="KOG3255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276293at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000003">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000004">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002359">
        <property type="entry name" value="Ribosomal_uL6_CS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF16">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00700">
        <property type="entry name" value="RIBOSOMAL_L6_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="4">
        <location>
            <begin position="12"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="4">
        <location>
            <begin position="98"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN98204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO00553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="190" mass="21593" checksum="BFC293256A181FCF" modified="2014-11-26" version="1">MVKIKSFSTLEIPEGVTVEVRGRKVTVTGKRGTLTKDLSHLQLDFRVDKKNRTFTAIRWFGSKIPIACLNTTKTHVQNMITGVTKGYRFKVRCAYAHFPINVSLDGPNIEVRNFLGEKRVRRQTVPSTVKVSQTDPSKVKDEIVFDGNDLEQVSREAAVLHQMCLVRKKDIRKFLDGIYVQTKTNVEAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RT13</accession>
    <name>A0A088RT13_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_261490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699969.1">
        <property type="nucleotide sequence ID" value="XM_010701667.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22576052"/>
    <dbReference type="KEGG" id="lpan:LPMP_261490"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260020200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_261490"/>
    <dbReference type="eggNOG" id="ENOG502SJ1J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266490at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="585"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="743"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="809"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1220"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1459"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="282"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="616"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="747"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1220"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1241"/>
            <end position="1250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1481" mass="154401" checksum="A136CB4FBE99BD58" modified="2014-11-26" version="1">MNHDDTTGVPTSAAIANSSTCATVPGGMAQTRMLSRLRVAGSTGIRRVNEASEAPLAPLPSARPLGRDASTTGDVAQYGGCASLVRTATAAAVVAVENAVPQSSAFGCGDGRDDDAVLRKEENSCIEVDVGAVNASSPLLGQPTSGAAQHLSYDAANDGTGGRLQSRGGNAAAVDIPLRCRATWTRQTTPEPLQGDGGLLCAAAALNSSTTSSADDKTSPQSAAAAATATDVLESPAAPPPSPKGEHGSCDYTGNPLHLPGHHRHYIDMDLPGMGESNEPWSGSVASSASSAPHSTAETQWHNTSVASELDLYEMPLPVMETATGDLTAAPSVTASFLFGGVALPVAFSVKSGGSALTADRDAKVWSPISVSATVSPSRRNIAGLKQPADLSGWRRKRSSGKLAVQSERNNSSSGPGDIPLVSLEKSVGWSAGKPMNDDSLSPVTSLSQQRGELLERSVYPLTSTQVTTATTLATVESGTASNPFSSHSSLRSFDSHHALQRSALIARMSVPCQGRAPSLQLSAIVRPGGAVLESANLGTPVRSPQGMSTSLGLPMFVGGSTGSPILFSKYDTVFPLRMAPRTHTKLAGDESQQSPPRLHDQRNEGDADQPPPTPTAALVTQAAQQQQQQQTPFCCPQHGETDAPECSPLTSLSALPQQSLRSSTVTSDTSFGVDNAISMRQCSMMSEDHILQTLVHGMALGGVSAEAWMAAPDNWAPSPRNLRSTGPGNRHLTGRLCALQRPLSPSSHSAASDAVGAGSGKTPTAGLVASSMRFSQLQTQRGKLGWMSSTRPAGPWGAELVQGLSPVSASAANRGDETAETGSHLLTRDPLTVAPSSPSKRHMAAHTPTRLQQQRKLPSPENFFAKADGSLRDSVGFSATSLPTLSDPALHARRSLVTPMQGYSFKQHSTAASMASSALSQVPLGVEEVIFSAGSTPNVVGCVEASVVTWLPVASTDTAARQLSGDQTVVLRPYDSSAAYYRISNGGLFSTADSGVTVAAPREASLEGRLTFLQSVHDLDSFAAQAEASASLGYGAAVQSPLTREIVEPGAVATTMVSPPSSIAPVDETFSVCRPPPPAPAMLLRHSPTRRPFYLIPGLEAAATAELGRISPSPFTVAPWAIGGASDFVAAVATPLLPGMLSGKDKVSPWSSDSTRGGFLQVLPLAQEEHVSTSLSYKVRAPKTTSPMSASQAQDDSVAVTDPQLLWWAPKAAHAAAPFTATDTDTRPASVHRNSDESGTHSSMPNFSCRSPPVHLPPQQQTPPQLQVCAPAAMWSFLYGVHNNDDQGAYQIATFNSNPSVALTRSSTRGLSSCIVDQAADVWPGGEEEYRQSCRPEGEMLFRRPGTLTGSISQCRRSGKRRGGGPGAPLRISIPCYQRYRDVEALLDDAERAMNRTSVPIISLLSYGGRSLNGDEYSPETLGNGLASSVMSLATPALMTSMTCLEVSLVSPLALESASDKPVASPTGTMSFSVSPPRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTC6</accession>
    <name>A0A088RTC6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_270260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700114.1">
        <property type="nucleotide sequence ID" value="XM_010701812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTC6"/>
    <dbReference type="GeneID" id="22576202"/>
    <dbReference type="KEGG" id="lpan:LPMP_270260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270008100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_270260"/>
    <dbReference type="eggNOG" id="ENOG502SCIK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272507at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="326" mass="35264" checksum="B2C19ADDECA254E8" modified="2014-11-26" version="1">MWRLHIPTSLSEGPTDSGVSILVGQRSYVSFANETPCTVCALAGYVQCDDPSVLEEQIECLEHVLPFGIEVLGFAGDTVTLTSLAAQMPDLKRKELIEVVVHSGEGHRRLAYRMFGASAKKVEVVEDEIAFVEVRCALHTYDSPSPLLVSCSNALPQVVDGEGYAPLMERAPAPSSKMELIQTGAVSSTLRFHVVMVPSLLSARGLYETLFRQLKAASTAGTTRLIELNAHNAHLSYCCRLKCRADALASRGAITEEEWAVVLEMIEDATGQRVSRGDVRGAKPLHHSGEKSKAPEAKTANNLPAQLPLCFLSLLVVLLAVALLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTX7</accession>
    <name>A0A088RTX7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aromatic-ring hydroxylase/flavoprotein monooxygenase, putative</fullName>
            <ecNumber evidence="4">1.14.13.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_262580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.14.13.1" evidence="4"/>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700077.1">
        <property type="nucleotide sequence ID" value="XM_010701775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTX7"/>
    <dbReference type="GeneID" id="22576161"/>
    <dbReference type="KEGG" id="lpan:LPMP_262580"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260030600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_262580"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="47494at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018658">
        <property type="term" value="F:salicylate 1-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF309">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839080" evidence="3">
        <location>
            <begin position="17"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN99370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="454" mass="50771" checksum="449F462493CE97F9" modified="2014-11-26" version="1">MRVVIVGAGLSGLSLAAFLRRLNVDCVVLEQAPFLQANYIAPYTLFANALSCFKAFDLEHIFTSSRMQPEECFGIQGDRGNWLLKISNRNIRLPALGAEDVVPLSTAPPANSESIVSQRLSENRKQEMGYVPLRCTLPASYLREALRRHIPEIKFSAQVIDLLPHNGVKGGVHAVLEDGRTEWGDVVVGADGICSTIRRLLYPGEYVGTSSRTLGMIHIDGFVDCPHCPPHLVQPVECWGRGRTLQTVPFHRFGENTLAFSATLHSSPRELVDLQRGMDAMEVLQTFRHLLGREYAGFGGEVGTLLSEAKLAVPTEVLEVPVMPRWYNRRAVLMGEAAHGSLPSFLNQDASLCVEDAAILAVALLDVPLQRDSGFEYAFRQYETVRRDRIERYIRQSRRARKLTSMKNATLRNALLRLTSPIVVNLAQRWLSNWTYSSQQLMVDPKTKLETAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RU30</accession>
    <name>A0A088RU30_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_241110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699451.1">
        <property type="nucleotide sequence ID" value="XM_010701149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RU30"/>
    <dbReference type="GeneID" id="22575520"/>
    <dbReference type="KEGG" id="lpan:LPMP_241110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240017300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_241110"/>
    <dbReference type="eggNOG" id="ENOG502SI6R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265897at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31152">
        <property type="entry name" value="PLAC8 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31152:SF1">
        <property type="entry name" value="PLAC8 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="785"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="835" mass="91776" checksum="5B43709D422E6C60" modified="2014-11-26" version="1">MPYYENHLYGPAERTPSPRQLRLPVATESPMRAARSEGPLIPTDENDNDAAEWFIRRNRRIPSPILSPIPTNPAYYSHHEEDDYNSNLQEGAGEAQQRRWMRERDSSRHPPVEPVVGHNLSSNPRTEEAFLSIPRAASLLQTRQVQAPSTGPRARAEVEAFTEDQQDADEHMTEEGLVSSRPFPTGWDARERPSFGTAAYRSAADEADYSAEPVARPQWLAHNSDESAHQSRSVRSARRYEDEGSERYRALWAGPERQVPRKSLPVRCARCDYRLPEELIEYLLETSMYHSVPQPHCPECGAQLAPIAQATYGDGDDNVYHSEREPPRRRERRSKRVNMPPKGPYERRSISAESSNTDIGVIDAVSSSNGDSRHESQLSPGVTPRPSHSKIEPENPAPLPPPRQPKAPMPPPRFGAPGGTGWTPRETPIIVLAKSPYLTLDSLPRSLHSATKGVTPSSDWHPGEEVTSAISPGNIAVPWAVEGCTACRRQAGVGLAGLFCCAMPCVLFRERKQLLLHTPSSRYICCAGAFPCCVPPASLRPELYYTVGPNYLYSSAMDAETTRYLDSVEDPTTAASQQRHRYDLYSAIDDEGEEQVTALRLAGGGRPPLAAFRSVTGVTSPALLVNPQTGLPLDGCYSKLADHGVDRPFANRATSPTSAPPGTGCCDCITWIDNTCVCDKTRGCCLYCTHPTAYCLACPMLCLCCEMTWCMPCALWTNRLLIRQHYHLLPDTAIDGGAVCCYRSYLQCCTLACTQAYTPTMASGTSTRVESTAAATASPTSLSCWFQLTITVAACLAAVFCLCPCAACGLAQQRDQIQRLGYPLVVQIPSETEMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUC4</accession>
    <name>A0A088RUC4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">DNA repair protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_280780</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700419.1">
        <property type="nucleotide sequence ID" value="XM_010702117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUC4"/>
    <dbReference type="GeneID" id="22576523"/>
    <dbReference type="KEGG" id="lpan:LPMP_280780"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280013300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_280780"/>
    <dbReference type="eggNOG" id="KOG1001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF22">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="163"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="425"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="505"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="689"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="705"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIN99712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="736" mass="82899" checksum="CE0DF2D03C44179B" modified="2014-11-26" version="1">MNTQLLPFQKEGVGWMTQREMSHVGGIMADHLGMGKTVQMIGLCLVSDKINKGLYSKQMQQRRMLAEGSRLITVLRQLQRISVIANCSRINRPADDLSSLISQTTDLLKTKQGSYKGVRAEIDKWLTFAGKFHSAYQKRALDFLDDVEKRDFHFINSKELRTLVVVPAALMLQWKSEIESKVKASRKITVYLYHGESKLISNTELETFDFVITTYDTLTNSAASAFIPGDDPRTFSFNRREAGPLFHIQWKRIILDEAHMIRHVRTQRWRAVQELQGLHRWAVTATPLHNSIDDLQNLLHFIGLPRLPVLPGGNTEELLADPLLQRSIARSLQPAFLRRGPVMMRNGVREVLVKLPPKTEVVIKQPFSVRESHMYNSILARSRSALATSENKEGVFHIFAMMTRLRQACCHSWISQGRAIQISVCGICKSEASSPVATKCSHVFCHECLLLRFRDAVDGDNIAVRIQCPTCAQTITFSSVFKKTTLTSTQRIAQYKNNEFELSTKLRMVLRSIHDMQKNHPADKMIIFSQFTSFMDVISISLDRYNIAFLRIDGTMSLSNRNAVIRQFQTSEHIKIVLASKTATGVGLNLTAANHVIVVDPWWNPAIEEQAVHRCYRIGQKKPVYVTRFIIADTIEQYCYEICQRKKEFGDAVLRAATAGDSGAKIAASRLQELMSRLKYVGDGEQADSSTQAFGAARDGDEGAQHSSSAAENESTHSPTFSSVQVNADESETTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUH2</accession>
    <name>A0A088RUH2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_281590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700499.1">
        <property type="nucleotide sequence ID" value="XM_010702197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUH2"/>
    <dbReference type="GeneID" id="22576604"/>
    <dbReference type="KEGG" id="lpan:LPMP_281590"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280022100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_281590"/>
    <dbReference type="eggNOG" id="ENOG502SNPS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269173at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006696">
        <property type="entry name" value="DUF423"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04241">
        <property type="entry name" value="DUF423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN99792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="138" mass="14426" checksum="C7B8EB024BA0A64B" modified="2014-11-26" version="1">MSANIRTALSGTNLPILAAGLSGGLGVVLGALGSHAFLELMDTNQFKAYNVANQYHLVHSMAMLVVAAIAPRVTEPAATYFRRAYLLFAAGTVLMSGSRYVHCTVHKPDFLSKFPAVGGAMLAAGWVCVALGGSTLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUL4</accession>
    <name>A0A088RUL4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_251020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699671.1">
        <property type="nucleotide sequence ID" value="XM_010701369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUL4"/>
    <dbReference type="GeneID" id="22575750"/>
    <dbReference type="KEGG" id="lpan:LPMP_251020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250016300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_251020"/>
    <dbReference type="eggNOG" id="ENOG502SDAN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268040at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="457" mass="49769" checksum="7012BC455D005EE9" modified="2014-11-26" version="1">MTSSHGGSSPEELPEELRQQLATLQTRNDHAQESLTALWQQPNAPASDNDLPAKPHKQTETYAVERPAAVAPTPTYTVTPPNHIQCNELDGEPLQPEESLIKPIMAYKAEDYPGGAARRDVGWEELVDGEPPMSDTRRSKNNSAQAQVGGIPKSVPHIRPPPAPMLGEVFRRLPAGVSLSYLRSNHTESQLQSHLSEFETSKPEIANSNELDVPLRGSANYARISSLVPRTAPPPSQLPDYLSLYASRNNEGANGGQLGWLATQPINNVDGQQGVLEQVSPLTPRAQDPGSTCATSAVSVAPAASAMLVATSTRAVARTGALTITMPTRFELTSAENGDVVEYDTLARSRHWSAENPKGTNYTKPSALLEAKEKRECALFDRYSRAYEKLMQDTADHVDGEEGALTRLSHKAFKAAREAADRKPIHKRSFYEGASLDWKKTLLEQAADISRISNRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUL8</accession>
    <name>A0A088RUL8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_280490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700390.1">
        <property type="nucleotide sequence ID" value="XM_010702088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUL8"/>
    <dbReference type="GeneID" id="22576494"/>
    <dbReference type="KEGG" id="lpan:LPMP_280490"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280010300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_280490"/>
    <dbReference type="eggNOG" id="ENOG502SPTY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265749at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="22937" checksum="E8C7B52826D69A9A" modified="2014-11-26" version="1">MCKPIVNTPPPLRQPTPSFKPQIVYSKNMSEAIGVVLNTTIDAVNATLQNTSSQLVSAATKMKPTEASSSIVGVMGDSLNIPQTTTAAPLTDNLKAMTTTSLSEEISQLSLVHLFAWILLFAAITLMTVVLLNCCLHSQKDSAYSAAKGDDAEEMHGKAAVLPSVPTPSTHPVGPSSGTSSSSRLLASRGNLARQQFLESRKTGSAAKCYGGTDSTSAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUM0</accession>
    <name>A0A088RUM0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_251070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699676.1">
        <property type="nucleotide sequence ID" value="XM_010701374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUM0"/>
    <dbReference type="GeneID" id="22575755"/>
    <dbReference type="KEGG" id="lpan:LPMP_251070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250016900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_251070"/>
    <dbReference type="eggNOG" id="ENOG502SD78">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266362at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="498"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="590"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="633"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="811"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="533"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="500"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="641"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="655"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="709"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="913" mass="98305" checksum="1F6719583C73B79A" modified="2014-11-26" version="1">MPHALTASRTDRNPSPTSSSSTEQYHPIRRPPAAAVAAAPGIAVAAAHNELYHSGTHSYALEPDEHEDINNLTMPVATHVKHQAASSSPRGHQKQQHTVLSPSRLWSPARSTGARAGQTTPSAVPRPSYHAASPPRSPPVPSSHSHASRTGIVNGSGYHHSTRKTALLHTPELVSLSPTTSRQPPQRRSPCMNRQSTSVLTEAAPATKKTTLLLPAPLNTTSATPSTSGHVATGAAAAPVAAVPSDSQPSSTAQWQLSSPGGYRHRSDGHVPQRGAVFAYASEAVNTLELQYGDALQRLNRMHRLYDRLDAHNLTLASELKRLRQVNDVLQNGVAFPLYNSVRLVKHEMKLLKQYVELLCSSFNNQLVVLQQVVGEELPRVLGRYDPYTSLLAHGAEGQLQPIETRVSIGAASGEASPLGRVIKEPCLVLGRHVSGAGGAVAAGTQLYSPEYWWNAMSPHSMRPPTATDTREAPAEVEAYRCADVVDGRGDGITEGERALSQQGQLSLSNEESRECNVPSQSPQEALVSRRAYQEVRAALADAQRRVAELEQATSSHQGDYENRIAQLKAAHRAKETTLKEELALLRRRAEGTQEGDPQQTALATRPAGQAGNLVTPVDVNELAQLLLERQYQQPTAKQHPNTSSTASNPASTWRPEDADETTRQVEGQCDNEGVTTTTNGSGRDYHCRTARPCAAASASASNTDDDNNDVRHSFDRRGADGSVHTPDCNLPSSAAGRVQRAREVLGCEQGQRAQTCSISSHHQREKVEASKKASATTIAQHSLAYGRLMGHSHPPSRSLEGNAIHTESSAARMQPCKASDANSHSVSRRRSRHCWQSTGGAVRDARHDVAADTELLQLLLAQVAAIGAQAGSQCAATVPKRVPPAPNHLDTTVNRVAQGIWAQKRLKERHYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUV5</accession>
    <name>A0A088RUV5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_281700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700510.1">
        <property type="nucleotide sequence ID" value="XM_010702208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUV5"/>
    <dbReference type="GeneID" id="22576615"/>
    <dbReference type="KEGG" id="lpan:LPMP_281700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280023500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_281700"/>
    <dbReference type="eggNOG" id="ENOG502S07S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250130at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="426" mass="44651" checksum="AD969B5816A80B13" modified="2014-11-26" version="1">MESLQMQWVECPLLDAAGVVLHPPSGSDDDDDGDDPIDLLNRREGHCSAVVYPVTSIDVPAASSRESWVLVCGGYSNGSVSATPLVARTTLLPALQWVRLPPVDALECDGATLTTVGSAVGVEAMPTTASASSALSGVCTTAAPAAYLFGGLDADMNRRNTLYAVTLHIDADATPVMVQVAEVQCTGTPPEARVRHGAGGHAGCLYIFGGETDTQEQSSDLYVCDVQAGVWRVLASPSPLLSPAPRLLSLSLLFMTPTTFVLYGGAHFVNGDLRSFADVWSFDLATETWSVVVPPEANDSTPGSEWRADAPQRVLPPSNGHAGCVFALRPSGSATYVCAAFLGGKNTSEGDDAVKLVCFRPQTKTIEVCARSATPVAVSRKLPHWRYTPAVVSTEKGLLLLAGQCRHPQTPSAFLLTVSIGGVGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUZ1</accession>
    <name>A0A088RUZ1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_282100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700550.1">
        <property type="nucleotide sequence ID" value="XM_010702248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUZ1"/>
    <dbReference type="GeneID" id="22576655"/>
    <dbReference type="KEGG" id="lpan:LPMP_282100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000037200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_282100"/>
    <dbReference type="eggNOG" id="KOG4308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="333024at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045203">
        <property type="entry name" value="RanGAP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46761">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46761:SF2">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="374"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="605"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="756"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="573"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="374"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="385"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="613"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="643"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="758"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="779" mass="84837" checksum="567D910EDA9A3E38" modified="2014-11-26" version="1">MALEHCAAAELYISACKREHAQISDALVQALDRDVKAAAHGQGSVPLNDVDVRCIAEMISTLGDNNQLRVLVLEENSFGLPGVTALMEAIEDNPSHIRELRLGKNNLKDQAAVVIGHTLSRNGCGLKVLDLSENNITKLGVIPIAAALQQPFSEIVELSFHNNKIECDAALYLSQALRAAPKLKHLHLGYNALRDNGAAQIARSLPHASCLSTLDLTANRISREGGEELARALMTPTCTVQRLNLRHNQLDSETIVLFADVIAHNTSLIQLFLGFMNPSPEAAAAVLSAIPRNNTLLLLDIYGWKLSPKNTPALIRAVQENNSTLAALVTDACEFIASQVDESNVMREEKLDLHPVYVGPDDRDAYLATKSLRRYSRAQSRRQSRAPSRVQSRAPSRVQSRAPSRVQSRAPSRVQSRAPSRAQSRTRADGQPASRTTSSHRRSERDGSRPASRSLRTVSPPERETAQEQAPLPQHSSPRHRQHKSGSPRRHRHRHGERVAIDPASVTSPSVRARTPHAVAVSEHTASRSPRSAGEHLLLVASKKIDEIIDASVNELQDTPCDPHTTRMLKTAIKAQQNTIKQQSEQIQALTARVEALEGRRECHCGIGGGGKSRASSSSQRSGSPRNPGQLTRHRSKHALSAARQSSANGSAYQPTNNKAGLSVYGKAATTNAEGNGSCAHFGQQYQMQATTTANSFQRSMSRMSQNTSITIVERCTTPYVSQDVPPDIAHSNDESGEHHPEGVELQRSAIIQTFPPCIEPSPTQDPNPPLRKSVSHAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RV84</accession>
    <name>A0A088RV84_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">U5 snRNP-specific 40 kDa protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_283110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700650.1">
        <property type="nucleotide sequence ID" value="XM_010702348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RV84"/>
    <dbReference type="GeneID" id="22576756"/>
    <dbReference type="KEGG" id="lpan:LPMP_283110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280038100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_283110"/>
    <dbReference type="eggNOG" id="KOG0265">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269529at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052234">
        <property type="entry name" value="U5_snRNP_Component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006:SF1">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="322" mass="33688" checksum="A906872858DEC6C7" modified="2014-11-26" version="1">MALAVTSSSAPSGRAEVVYWNLHGHSEDVVCAATHGRVCATGDVDGVVLLWRFAKAAPEHVCSMNTGGPAAVDAAWSSATTLLVAQGDGCATVWDVEKGARLRTISRYAVKGRCEWPVVNCVAVTTQDSFVFGGDDGYLVTADKRSDRVVVGARVAVPLTSATTAGFSLFIGDVCGTLHWFDIRTGSREVERIVCGSAGITSIVADPTQDRVVTYSMSGTAQMIDTQPFALSSSDRLLGATELGVNERQALLRGAWVPRSDTVVMPSGKGNVVSVFASDIVGGAMRTVHAGRTGSAMNVSVCVEDEYVVCGGDGGEVAAYQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVA9</accession>
    <name>A0A088RVA9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Adenine DNA glycosylase</fullName>
            <ecNumber evidence="3 13">3.2.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LPMP_282270</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Adenine glycosylase active on G-A mispairs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.</text>
            <dbReference type="EC" id="3.2.2.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the Nth/MutY family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.31" evidence="3 13"/>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700567.1">
        <property type="nucleotide sequence ID" value="XM_010702265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVA9"/>
    <dbReference type="GeneID" id="22576672"/>
    <dbReference type="KEGG" id="lpan:LPMP_282270"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280029000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_282270"/>
    <dbReference type="eggNOG" id="KOG2457">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10248838at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034039">
        <property type="term" value="F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035485">
        <property type="term" value="F:adenine/guanine mispair binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032357">
        <property type="term" value="F:oxidized purine DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000701">
        <property type="term" value="F:purine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03431">
        <property type="entry name" value="NUDIX_DNA_Glycosylase_C-MutY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000002">
        <property type="entry name" value="Adenine DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044298">
        <property type="entry name" value="MIG/MutY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029119">
        <property type="entry name" value="MutY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944">
        <property type="entry name" value="ADENINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944:SF1">
        <property type="entry name" value="ADENINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14815">
        <property type="entry name" value="NUDIX_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="14">
        <location>
            <begin position="79"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AIN99860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="491" mass="54476" checksum="231B907A4DE73F8C" modified="2014-11-26" version="1">MRGEWLTPLGSSATHEYYRSIQEKVIVWWREHQRQDLPWRQTLPRGSGDVSGEFAGEDHRTSATTPRYDPYRVWVSEVMSQQTRMETVIPYYIAWMKKFPSIRTLAASTEDEVKSVWAGMGYYRRAMNLRKGAQYLLEWSKERGETATPCMPSSQEELLKVPGIGPYTSAAIASMCFGESVCSVDGNVIRVLSRLRGERDFDPKVSANIKEATRWGQELMGNSPTTSAVICRDPSALNQGLMELGASVCRPGGVPLCISCPLEQFCCASALVRCGEIEAIEGIIPVRAAKMAKRSVREICVVHEMSADRACDARRFVIVRRPADGLLGGMLEFPTVSASAADDEEVAVHLVKHPLSVLTWKAKARPTGVRLCGTVRHIFSHISMDVEVVHVQWPAGTDGAALLKRVAEVVDDHCTGDYCKLCPTAARIFLMSEADLRQSAPSRLMLKVLQRISPMEVKRVRGSRAGTLAIQEGSDILSPQKKVSRRELGHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVJ1</accession>
    <name>A0A088RVJ1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">40S ribosomal protein S33, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">S33-1</name>
        <name evidence="5" type="synonym">S33-2</name>
        <name evidence="4" type="ORF">LPMP_261610</name>
        <name evidence="5" type="ORF">LPMP_261620</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699981.1">
        <property type="nucleotide sequence ID" value="XM_010701679.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699982.1">
        <property type="nucleotide sequence ID" value="XM_010701680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVJ1"/>
    <dbReference type="SMR" id="A0A088RVJ1"/>
    <dbReference type="GeneID" id="22576064"/>
    <dbReference type="GeneID" id="22576065"/>
    <dbReference type="KEGG" id="lpan:LPMP_261610"/>
    <dbReference type="KEGG" id="lpan:LPMP_261620"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260021600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_261610"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_261620"/>
    <dbReference type="eggNOG" id="KOG3502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10258930at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04457">
        <property type="entry name" value="S1_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000145">
        <property type="entry name" value="30S ribosomal protein S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000289">
        <property type="entry name" value="Ribosomal_eS28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028626">
        <property type="entry name" value="Ribosomal_eS28_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01200">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00961">
        <property type="entry name" value="RIBOSOMAL_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN99274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN99275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="87" mass="9716" checksum="AD3494AF96672796" modified="2014-11-26" version="1">MADSKKDNKKTEEVVAQGTDQAQVGLIIKVLGRTGSRGNVTQVRVRLMAEAGSPDYNRTIVRNVKGPCKENDMLSLMETEREARRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVS0</accession>
    <name>A0A088RVS0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_262570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700076.1">
        <property type="nucleotide sequence ID" value="XM_010701774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVS0"/>
    <dbReference type="GeneID" id="22576160"/>
    <dbReference type="KEGG" id="lpan:LPMP_262570"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260030500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_262570"/>
    <dbReference type="eggNOG" id="ENOG502SHWN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265447at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="540"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="644"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="699" mass="75190" checksum="CE85EE762FDB5C78" modified="2014-11-26" version="1">MEAALGIRVPRPTSTAPFAARSLVRQFVDSWRDAAGKWKRLRGEGKTSEDTETQNVKHVKREGGNETDIWQRLPDSSLAHPDDTPAWAVELGIALERCRGLLESPIYTAAAQHQVQSSSLRATLAVSSATEALPALPRMQPVSSAAVPPTPVAARDSSATLLCEAELICAREGTKTLLPMYTELHALRRMRAEREQVAAQTVVEQLEWEQRRLMDMLAECDAQLQMLDSNFVDSCQARLAPLETLQERIDALHKFHRQLEAHAAAMWPLASKDGATAPKYALVATELATRVPRPVGLVGVALSQCMAEERLAWERKWEALQTALSEQRKRNAELQACYIQANAQLHTTLERDNYVTKEVLNAVKAQHRADTEALVEQLGWTLINNTSDVLSLRHPGTSATLHVNPAYSTINGQACEDIAKTLAAYILQHGGATAKMVEPAAVSPASVSADETRGIVSEDHAGGNLGLPSPFPDQTSHCEGGAESIDEVMLQEAGQGAEETVLTVTDNEVTQAAPFSRSASAHDESPSALSSQRSPPPPETEVTPVAEPPMRATSVSIDREVAEVMPQLPISPEAAAESVGEGNYRSSAQEPCGGASAASDDTSRGGNGEDDLEAYMEEGNSVGRDEKDGERDAKDAEEDLADYSSVQAQGGSNNISTLSVSGNLPSSGSKGDDARAAPVQPAPYESFFSPSQLWENEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RW33</accession>
    <name>A0A088RW33_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_270970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700186.1">
        <property type="nucleotide sequence ID" value="XM_010701884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RW33"/>
    <dbReference type="GeneID" id="22576275"/>
    <dbReference type="KEGG" id="lpan:LPMP_270970"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270016900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_270970"/>
    <dbReference type="eggNOG" id="ENOG502S78X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272472at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="281" mass="30104" checksum="B8110BD0DD7C98E4" modified="2014-11-26" version="1">MKCDRKEDKEAEVGGSRPGSSDHLRISTTTLPKRRRLVKGSEVGLPLHASVIEETCEVEEVHTVLVRFPCFDFFRHVRVCERTRDPRPAKSSDAVKGSATPARELPDVVICDGGAPPITSSHGVAEATFAPEAALFIPGTLETDTPQLLLNAGTPCEMRFEGQWTEVIGEGASITNRAIVHVSSKTTGTAVPPAALPLSSSAVVSDAAKSPEPACLNVESLPASSSQATTTPAQPIASLLTHTLAGVTADEERRQRAEQRKGWTYDRIDVPSAVLVMHRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RW36</accession>
    <name>A0A088RW36_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_292620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700866.1">
        <property type="nucleotide sequence ID" value="XM_010702564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RW36"/>
    <dbReference type="GeneID" id="22577025"/>
    <dbReference type="KEGG" id="lpan:LPMP_292620"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290028700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_292620"/>
    <dbReference type="eggNOG" id="ENOG502SKB8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273514at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="641"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="712" mass="77936" checksum="68C69386C5E7C3DF" modified="2014-11-26" version="1">MSFFANPLAEEEVVPPDYPLEQYDELKREDDFNELLVRSTKLEGRQSSGDDGTPANPELEACLRHIRQLRSSLESTWLRMSESPIEPTREARIVHTVETSNLSTSNSSFIGALDSAITQVHHHVAQRERLNEHLRALVKQEAAQFSSSAPHPLAASVVCALNAPNLRWSPETLSSPHSSEVVAERAAGAVRALETLLPSMSMEEVALASAAMQQLSYGLQSWSALKHRCDALRATVAVKLQEQAETHCAAEVFARWTAQRQLACGEAAASQAPSPATITPSFDIAAVECLNKELSEENRRLEVVLARLLAIQQLDKAQPDAFAGSALVQYVSLTDSARELEEETDRLGRAVLYLRSILAEPSTMESWGACSAGGAAALSTQNPSHEGTKRLARRLSRIHAVKKELWPRQAVSDGVETVSDTVNTILSLGLNRLLEVHNVCLHAMALLSTYFEKQSGNAAFLSHAMRGGGVVEDATVERVLDVQPPDAGLVRQCCANMRNLSAELEATLRSIVEKSITASTAHLTQWKAVRGLLTELLQSALVTTPDVHAEFSARLAAYAAPNTPSATTTSSVSEMVTQVHARLDWATTVLAEEAKAFADEKATQREVIMAFWAAQITEVKKKMAWLEKQPNAPLLTQLCDVERENEQLRHQLASMQEASEDASVLDRTLAELQKCTAEEARCNATVRAELEELEAARRELETQRDALLSSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWT9</accession>
    <name>A0A088RWT9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATPase V0 complex subunit e1/e2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_280650</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the V-ATPase e1/e2 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700406.1">
        <property type="nucleotide sequence ID" value="XM_010702104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWT9"/>
    <dbReference type="GeneID" id="22576510"/>
    <dbReference type="KEGG" id="lpan:LPMP_280650"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280012000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_280650"/>
    <dbReference type="eggNOG" id="ENOG502SB4J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1508846at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008389">
        <property type="entry name" value="ATPase_V0-cplx_e1/e2_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05493">
        <property type="entry name" value="ATP_synt_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839092" evidence="10">
        <location>
            <begin position="21"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN99699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="68" mass="7518" checksum="184F4D58820C5469" modified="2014-11-26" version="1">MGLFLGTFIFILLGAAGALSAPLWAKSQVDLVRVLCAVAAFCCWMSWVLIYMAQMNPLLLPTRSIQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWW0</accession>
    <name>A0A088RWW0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_302130</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701236.1">
        <property type="nucleotide sequence ID" value="XM_010702934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWW0"/>
    <dbReference type="GeneID" id="22577266"/>
    <dbReference type="KEGG" id="lpan:LPMP_302130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000020600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_302130"/>
    <dbReference type="eggNOG" id="KOG1815">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000043">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000965">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048962">
        <property type="entry name" value="ARIH1-like_UBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21235">
        <property type="entry name" value="UBA_ARI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="125"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="129"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIO00436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="518" mass="58546" checksum="215E158C42FF30F7" modified="2014-11-26" version="1">MYDPEYDREYYGEDEDDYTYEEQEAEPTVMGSADLMAEQKNEQCEGLTMDISEVLAMQSAVVHEVVNLTCLSTSMATLLLRRYRWSRDVAVERYFENSKKVLQDLGITEEASLHEATLCFGRAGAPTVCGICTMEYNPHEVACLSTCRHYFCLECWRDHIKSRILENLLGTSCPEQDCCELVGLFVMRELFAKCDNKAQSEESEKILGQIHRKYLTGFVETCPTLYWCPNPHGCTAVIYAPVPPLQGQGVLCLLCNSMYCLRCSYEPHRPATCENMRQWKNYCSKEGANLAYILSRTKQCPECKKTIEKSGGCNHMTCKCSHEFCWVCLGPWRQHSGDYYSCRNVEHHGAAASEEAMDSSKRFTYHYERYTLHLDSAERDEKLIHTLLHNPAMREQLIKAQRVVDGKRGPGVVSGALTQEEVALVDSTCAKSEVVSRVTKTLFTAREVLAHSYVAMFYLSDNGNEGQLMAHRVGKLEEATEAMSGSLVKLITSTKSQMSTFFDAADVLVAWTKALCDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWX9</accession>
    <name>A0A088RWX9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Electron transfer flavoprotein subunit alpha</fullName>
            <shortName evidence="3">Alpha-ETF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_281210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="3 4">Binds 1 FAD per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99754.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700461.1">
        <property type="nucleotide sequence ID" value="XM_010702159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWX9"/>
    <dbReference type="GeneID" id="22576566"/>
    <dbReference type="KEGG" id="lpan:LPMP_281210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280018000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_281210"/>
    <dbReference type="eggNOG" id="KOG3954">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1715808at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000041">
        <property type="entry name" value="Electron transfer flavoprotein alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000048">
        <property type="entry name" value="Electron-transfer-flavoprotein, alpha polypeptide, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153:SF1">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000089-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN99754.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="325" mass="33770" checksum="B67EE149CF57B39E" modified="2026-01-28" version="2">MLRATALSLGKALVVAEMVGGKVSPATLAAITAASKVGPVTVLVAGASAKNEAQVLAKVKSVQNVLAVEAAQYSHGLPEEYAPLIDAAVKANSYTHVLAGTSAFGKNVIPRAAAKQCCMPIPEVTEIKDERTFVRQTYAGNAITTVKSSDKIMYCTLRGTTFPRAEVEGGSAEVVDFAATPAVGKAKFIADQISTSDKPDLATAATVISGGRGMKNGDNFKLLEELATPLRAAVGATRAVVDAGYVPNEMQVGQTGKTVAPNFYLACGISGAIQHVAGMKDSKVIAVVNTDPEAPFFQIADYGIVEDLFKVVPELTKRVKEAAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RX10</accession>
    <name>A0A088RX10_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF423 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_281610</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700501.1">
        <property type="nucleotide sequence ID" value="XM_010702199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RX10"/>
    <dbReference type="GeneID" id="22576606"/>
    <dbReference type="KEGG" id="lpan:LPMP_281610"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280022300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_281610"/>
    <dbReference type="eggNOG" id="ENOG502SPNH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269173at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006696">
        <property type="entry name" value="DUF423"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04241">
        <property type="entry name" value="DUF423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN99794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="13004" checksum="F5B70E31F26DF3EE" modified="2014-11-26" version="1">MVSIPLAYSGVLGLTGVIAGAVGSHGLKAKTVEERNAFAVGSQYQLMHSIAALGAIALSQTVRSLNPTAAKRLHIAAWMFLVGTTLFSGTVYARVFGAPTSIRQVAPAGGYLMMGGWACLIAAAVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXH0</accession>
    <name>A0A088RXH0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_290230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIN99974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700917.1">
        <property type="nucleotide sequence ID" value="XM_010702615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXH0"/>
    <dbReference type="GeneID" id="22576787"/>
    <dbReference type="KEGG" id="lpan:LPMP_290230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290007300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_290230"/>
    <dbReference type="eggNOG" id="ENOG502RZD8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="258418at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="215" mass="24614" checksum="C36E1BC2B5B6E8C1" modified="2014-11-26" version="1">MFRLSSRRLLLDKLSQTRLGSEVLAQTRSEMQHLERKDSALMRFMSRRRPIDYLAIEVDGPVTKELHPSFRYVKNIITCFVFVPFVVLLVAGHLQPTYYFLVCTGLVPYDHYVQMWSFSNWAIVLVGQLFFALVVYDLSVYVRYPLFAHVLAPAYRKMGWFRPSPAASLTLEQLKTGASRRVQARPLGRPLGEVRRGKKPAAAPTAGPLRRTPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RY66</accession>
    <name>A0A088RY66_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_320010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO00891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701691.1">
        <property type="nucleotide sequence ID" value="XM_010703389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RY66"/>
    <dbReference type="GeneID" id="22577742"/>
    <dbReference type="KEGG" id="lpan:LPMP_320010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320005100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_320010"/>
    <dbReference type="eggNOG" id="ENOG502S30G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268628at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="134" mass="15823" checksum="0387D588D08FA97B" modified="2014-11-26" version="1">MFRATVVRHLGSPTYGNWPWPSRLPLKKNWFYHLSRRESIADEKRQFMVMGDFLILCVLSFSLYRVYVLNRNNSYQTHLCHLVSFPPAIIANEFDFQDMNANRRVERKDLDAYREAVVSCKGAGRPIESIIFNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYB3</accession>
    <name>A0A088RYB3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein-tyrosine phosphatase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_321080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO00994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701794.1">
        <property type="nucleotide sequence ID" value="XM_010703492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYB3"/>
    <dbReference type="GeneID" id="22577849"/>
    <dbReference type="KEGG" id="lpan:LPMP_321080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320016100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_321080"/>
    <dbReference type="eggNOG" id="KOG1572">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14501">
        <property type="entry name" value="PFA-DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000187">
        <property type="entry name" value="Tyrosine phosphatase family, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004861">
        <property type="entry name" value="Siw14-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF58">
        <property type="entry name" value="TYROSINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03162">
        <property type="entry name" value="Y_phosphatase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="422" mass="46760" checksum="AC1C8A665818F8EF" modified="2014-11-26" version="1">MASPSKANGPILVPPSNFAMVEDGIYRSAYPTEANVLYLRHIGITHIVLLSIEQLPGPVKRLLGSEVTGKAASSCLTRGPIHIMDIVDMHTWCVDGMNSGDDFSCRDVIRALDFAVDRRWHPVLFACPLGELQTNVLIGCMRRYQHWALSTIFSECELYTTVCRTLRQSILLFIESWDPANNPISSVNVQYRNREMMLRERLRAQQERRKHRHASAAFEGNRSRTSDSDSIEDMADEDEALTSVMSDLLDKISVDGRNSNTVLTMQHAYNEMSVAVTSPPADLKAPNPDAASISTSGQRPPMMVRRAAAAAAAARLRERQEKQLHNEISPSEAEGQASFLEVEEGKATGIIWAEWYLEALRVAEELRPQTYSSTSVSCGTVDMSLGADLPPPHVLYAGARNPPALDARSTFTKESIVEEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYE1</accession>
    <name>A0A088RYE1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Peptide deformylase</fullName>
            <ecNumber evidence="2 7">3.5.1.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_321380</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Removes the formyl group from the N-terminal Met of newly synthesized proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N-terminal N-formyl-L-methionyl-[peptide] + H2O = N-terminal L-methionyl-[peptide] + formate</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2 7"/>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701824.1">
        <property type="nucleotide sequence ID" value="XM_010703522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYE1"/>
    <dbReference type="GeneID" id="22577879"/>
    <dbReference type="KEGG" id="lpan:LPMP_321380"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320019400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_321380"/>
    <dbReference type="eggNOG" id="ENOG502RXAJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276063at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="entry name" value="Peptide deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PEPTIDE DEFORMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458:SF2">
        <property type="entry name" value="PEPTIDE DEFORMYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="Peptide deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO01024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="271" mass="30971" checksum="21716E6B1E65055A" modified="2014-11-26" version="1">MRRCMPWCRLVCGGSRLLREDANTRSEPTTGSSSFKQAVEEKLEKEFQELGRVACYPHRSMTRPVMLVPTSQILSPLFMSSLMDLKQLATNLHCLSFSAPKAHWDAAVMLIKSNPDEVEYEVWVNPSVPGYDDRNAVAPMYGMWENCISCGTATAWVVRPQRITCRGYNEHGREKVQVLDGMRARCLMHELDHLMGKTIFHQTMGPEFVVSSVAMAQRHLWPANFPSAEAYVTIPGQFFDYVQNTTVIPPGMEWWYAQNMRNEFGNERIEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZ06</accession>
    <name>A0A088RZ06_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_303180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701340.1">
        <property type="nucleotide sequence ID" value="XM_010703038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZ06"/>
    <dbReference type="GeneID" id="22577371"/>
    <dbReference type="KEGG" id="lpan:LPMP_303180"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300036700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_303180"/>
    <dbReference type="eggNOG" id="ENOG502RWA2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275114at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO00540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="410" mass="47385" checksum="C75F5EBB5E58B977" modified="2014-11-26" version="1">MRLFDVTRRLRGVGAARWHATYGAKVLKHKDMLTKYGDITVVKDVLTLLEQTESYISKWRLNKWEFRVPPLLCPAEREKVMLQQDMLKAICLNQAEERKQVFGDIQIVAAITGTSPESVREKNRAWLQEEASKLRWRGEVNKARELRDAFLRLEVYGSRDHRLLERLCCIYGMGMQGTFDEAFNNIIIQDLSTGKLSIDETNPFVELQAYIVSRYPQIDLIYDFLGLNVVSGYRPSLRRFLIHCLSKKNNIDNPVSNGRVLLHVSGSKETLFDFGDSENQIVHDDSIYGLPDFMYVRGSDVFLITIAANNHWLRKRQVPHAKQLEGIARRSSFVLGIPLDKVRIRNLLLPPNYVDSNSLRRLMESVLDMSQSSVREAAPWISLYVKELDTLDVDYCELEKTVNEEEWLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZ17</accession>
    <name>A0A088RZ17_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">T-complex protein 1 subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">CCT-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_323450</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702029.1">
        <property type="nucleotide sequence ID" value="XM_010703727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZ17"/>
    <dbReference type="GeneID" id="22578086"/>
    <dbReference type="KEGG" id="lpan:LPMP_323450"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320041000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_323450"/>
    <dbReference type="eggNOG" id="KOG0360">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="496at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03335">
        <property type="entry name" value="TCP1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000009">
        <property type="entry name" value="T-complex protein 1 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000070">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012715">
        <property type="entry name" value="Chap_CCT_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0346">Stress response</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIO01229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="546" mass="59312" checksum="E926411F613D28D5" modified="2014-11-26" version="1">MQPKQKAALGINGTRTSGIAVRRENVTAALAVANVVKSSLGPIGLDKMLVDDVGDVMVTNDGATILKSLDVEHPAARLLVDLAQLQDKEIGDGTTSVVILAAELLRRAQELVSQGIHATSIIAGYKLAMREALRYLNDNLVCAVDSLGKDVLLNVARTSMSSKILSNDVELFAKVVVDAIMSVKTVNDFGDVIYPRKAVSILLQHGRSLHESRLVQGFAMNLSRAAQGMPTSVKDAKIALIDFDLRAVKMKLGINITITDPSKAEAIRQRELDITKERIHKMISAGANVIMTTWGIEDSMMKYMVDNNVLGVRRVKKDDIRRIAKVTGAQVVHTMSDLEGEEVFDPKWLGQSEKVYEEHMGDDDCIVVSGTSNAVCATIVCRGANYFMLEEMERALNDALWAVARTCDASSVVAGGGSVEAAVSVYLDNFARTLSSREQLAVAEYAEALLIIPKVLALNAALDATDIVAKLRVEHTQAQSSSQQTEARFTGLDLHNGTLRNNIRAGVLEPKPSKVKSLQFATEAAVTVLRIDDCVRLHPDEEDQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZ19</accession>
    <name>A0A088RZ19_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LPMP_331110</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702203.1">
        <property type="nucleotide sequence ID" value="XM_010703901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZ19"/>
    <dbReference type="GeneID" id="22578264"/>
    <dbReference type="KEGG" id="lpan:LPMP_331110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330016200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_331110"/>
    <dbReference type="eggNOG" id="KOG0474">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="428525at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051280">
        <property type="entry name" value="Cl-channel/antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11689:SF68">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11689">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN CLC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0129">CBS domain</keyword>
    <keyword evidence="9 11" id="KW-0868">Chloride</keyword>
    <keyword evidence="6 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="544"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="575"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="608"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="13">
        <location>
            <begin position="694"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="13">
        <location>
            <begin position="800"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="415"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="888"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="423"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="888"/>
            <end position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIO01403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="911" mass="99357" checksum="2DF834D0886B0B9E" modified="2014-11-26" version="1">MARYESVDTYEAESMLYKDHLETRSHEPRWFMWVFVVVLGVATSALSVGMVTCLHMFNAVRYELLGFGLRGFTFVDAQRYPNVSEAPPVNVMGSSGRDTAHSASLDVWAMLRGNNVGLYGIASPRWYWSGYALWIAFAVCTSAVASGVCYLVPQSVGSGIPEVLAYLNGVSYPMMRSTRVLVAKLVAVVFTVASGVCTGHYGHLMLAGAMLGAQLLQRRHGVRCYHVHFVDHFRNPRDRRIVLVIGAAAGIAAAFCVSVGGLLVVLELLSAVYPVRFALYIFAACLLSTLFTQGYWSYSMNLDAPYRLHGGLLLREVVVLFRSHLPFGQHAAMNLMAFIPAFAIGLCSGACAVGFVRLSWAALYCRRRLEVWLRTKAIRYVLPILFTLLYVSVHYWVAVAFSAVPVTDEATTSALSGDSSAQASGRADSNTSSSSNGGAADEHTPAVCRPVPYTVRSGRNVTTIGFYGMNGFLCPAGSYPDVGAAGVYDAAPQEKGALGDKMTLQQQRQQTVRVVDAYASLAFSYADSTLQTLLSQRTEHLLPWPALLTFSLIYFFASAVYSGLGLYGDTMLSSLVIGAAIGRCIGAAVHSAAVAWNVNAATWADPGVFALFGAGSFVSATSGLSFGIGAILIECTADFRHLLPLMFAIAVARRVLLRWGRDVHTVYLEARAVPLLNAESYLGRYGLLDARHVMHSPVVSLPVVCTLDDVVRTLRSTTHHGFPVVSLNDGTFKGIVTRAQLELLLWHLIMTDGRTSHCTYDVMQRVEDHVFHSGWQSIDPTQRLRHERLHTDQVSLYPYVDTSAFTVLDTTSLPRTYEMFTTLGLRHLVVVDRSNYAVGIITRKDLIGDHLSAVLESQDSPTHTDRVPSSAVFAAALTSLRKPFHPTTAQVSEVARQSSMSNLAGPSPHHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZ43</accession>
    <name>A0A088RZ43_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proteasome regulatory non-ATP-ase subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_322960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AIO01181.1"/>
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    </dbReference>
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    <dbReference type="AlphaFoldDB" id="A0A088RZ43"/>
    <dbReference type="GeneID" id="22578037"/>
    <dbReference type="KEGG" id="lpan:LPMP_322960"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320036000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_322960"/>
    <dbReference type="eggNOG" id="KOG0687">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1452at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="26S proteasome regulatory subunit N7"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PCI_dom"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="214"/>
            <end position="380"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO01181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="408" mass="46503" checksum="ACF8F27FA367E82A" modified="2014-11-26" version="1">MSSPPPPRNIEEDLQRNEEEEPAPEVDDADIPVDPLLTLLYIRHTLTSPWSSSEEREAAKTALMEEMEKHNMAPYIRLVCEALGVPLDESKLAEMDAINAKKVAAFDARLKDAVDNLGDTEVRDVLQAKCDHYARIGDLEMCMKTNEECAAKTLATGPKLDLYFQRIRLGIAFSDNDIAAKGITDAHRLMKDGDWERRNRLRVYEGIYHVFIRDFQRGSALLLDSITTFASGELLTFQEFVFITVVASLPVLSRLELRRRIVYSPEVNRTSVDDVRDLVNSIYDCQYNKVFPNLEVVCQHLRKVVYLSPHVSYFFREMRVLIFTQFLDSYSSVTLESMGTAFGIPVPALDSMLCTLISNERIACKVDRVDGSVETYRGDTTNFDYHRIVKNGDLLLNRIQKLSRLVDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZ76</accession>
    <name>A0A088RZ76_LEIPA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_331660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AIO01458.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_010703956.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="22578319"/>
    <dbReference type="KEGG" id="lpan:LPMP_331660"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330023300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_331660"/>
    <dbReference type="eggNOG" id="ENOG502S4WR">
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    </dbReference>
    <dbReference type="OrthoDB" id="272988at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="511" mass="56430" checksum="59E11319FA2D5BE3" modified="2014-11-26" version="1">MGCRPLCGRLLSCLKRGGLWRSVRNGNYPDDTWALSPQCSARHATSSSVTLNFAAAFPTTTNQVSSLHDAFVSRFSAQLLSSPHRDITHVPYGDWFALYVQARKHWHSLESASTCATSATRERRKKEGKPEQTEAFEAREQRAKQAIDALLLSSVFARHWTEVQPSTTSSPSPLSTYRWWWHRDSLFTTASANAQDGEAVSPSLELCTPAFLTEPLLGGNHLHLWMEDIRASSGTTGVSRSAHDAAAAPTVILPFSTLWVVKQSAYWRPSAAPEAGVGESSGAASSSHETPAFTLQERQARQALLQSVDQLLQLQRDTVEHRKGTSGLPVDQLQHVCVLSPTQEWDLLCCLPRYRQALYNPARAASPKSTIVSEHSAAACVSSPRWLSLSCLCEDTTARLAYCTRVLNWRWQLKSSTNAATTKTTPVTIRVLSPSTEHAHLRSLSLFSLHEQSCMKASLQRRHAARRQSSSAASGESLGTTVHEQARKGCSDAVRRMSHREENIRQSFSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZH5</accession>
    <name>A0A088RZH5_LEIPA</name>
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        <submittedName>
            <fullName evidence="3">Membrane transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_310710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
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            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AIO00660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_010703158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZH5"/>
    <dbReference type="GeneID" id="22577497"/>
    <dbReference type="KEGG" id="lpan:LPMP_310710"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310012400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_310710"/>
    <dbReference type="eggNOG" id="ENOG502QYNF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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        <property type="entry name" value="Nodulin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06813">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
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        <location>
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            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Nodulin-like" evidence="2">
        <location>
            <begin position="45"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="255" mass="27770" checksum="AD97CACF71FDB7AD" modified="2014-11-26" version="1">MLHSVTIDNLRRFRILFAGVILLVSGSTQGIHSVFGVLHLQQAYQFNARSMAIVYLSGVSVGLFTLPFGALYDWFGPRVVVALGSVIAALGHLLFVLTFGGHIPPTVLNCAVFYAMMCWGCYALNVAVLPAVLTHMPRDRGQPTGLLQTFTGLGASVFACLFRGFFKDDFAHLMWFMFAVTLAAGAGGVTEREELCTPFPSCPLESLNMTHCTALCTVAPSCLFCFLLTPSFPFSRILTSPALPLCFEWHFLALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZJ1</accession>
    <name>A0A088RZJ1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_310920</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_010703178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZJ1"/>
    <dbReference type="GeneID" id="22577518"/>
    <dbReference type="KEGG" id="lpan:LPMP_310920"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310015800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_310920"/>
    <dbReference type="eggNOG" id="ENOG502RRIA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273559at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056661">
        <property type="entry name" value="DUF7759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056662">
        <property type="entry name" value="DUF7760"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056663">
        <property type="entry name" value="DUF7761"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056664">
        <property type="entry name" value="DUF7762"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42262:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42262">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24945">
        <property type="entry name" value="DUF7759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24949">
        <property type="entry name" value="DUF7760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24952">
        <property type="entry name" value="DUF7761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24953">
        <property type="entry name" value="DUF7762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7760" evidence="3">
        <location>
            <begin position="43"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7761" evidence="4">
        <location>
            <begin position="325"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7762" evidence="5">
        <location>
            <begin position="446"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7759" evidence="2">
        <location>
            <begin position="1037"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="672"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="728"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="967"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="735"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="767"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="890"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="987"/>
            <end position="1002"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO00680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1150" mass="124135" checksum="91322A587537DB9E" modified="2014-11-26" version="1">MHCSSRLSRMPQKRVSEAAERVPEPDPSECVNTVPATLRLNTHAATVRMKEKFTAPFMVYDAQARRIVANPQYDCTLTTELHRVQSIMLTKLRTPIQAHLSYTPKELLYELETALFHVCASLAVQDDASSLRYVLGDSEADLLMPQLESFLAHHNAPAKAVVALAKCLSEGTSNDVLTSFLQVLKQRVQQELDPAVDRKRSVHEHSALLATKNNLQDIVQLMRDMQTAYHSIDTASQIQRRQPQSDPTTVDLAQSPAANAVSARIVEDSFYKVLRWVVAVDADRRALHAATTGAAATAVEESHLATTPVPAAVATPSRSSAKAFARVVEYDPFTGRVTLERADAAQRWGLLLNSRGLLVGVENELRNSSEAGERLYDAIQQQSGEAGGLAIFEVNRHRIRAVHLSDEELASSGDDIMQKLRATLTHATKTLSLTIERRKQADLTVPREVLFEVSDQGGEGGVGQRCLLMMERASTSISWGLKLKYFKDSVAVLSDFAPRARLSSAAKNLLFDMRGRLRVLKVNNQDMAKLSAAEMKSLVSGSLLLSLHLQVTDSKGDVPPSVEAPPPPQGVLLPSAEEVGDAQEMPGVGAAPSEAQREAATLAEVEAAADMQAGPKDTGDSVQAELNDMAASIADEFLKQHSGEEELEAKAADKSEVPAVEEVDMVAADPFEELDWAKPTTTIGAPGDANDDEDNRDAEKDALFEESFRQQHYEEEDGVEDAIMEGFKGANDDEVLPKVEEADELIRGGEESAVTRKTAEDAGTAEEAARDVIETGRDDAEAEPSTKTREHEWATAKKAKESAKKGKKSAQVGGRQKKVGKSAEAGAQDADDNEDEPAQKAAEVDEKQLDEMEDNEAAEVSLGNATLTEETGTLPPQADPDDTAVGDAEAEVKAVSETKGRSRAKAKEVEANRSGVRSKSSAPAAAADEETCSTEPEGSGKGSTSAPVDVRLIDLPPTVAEVAIEHGRERITKRERHSAKATATETEVGKEERGGGKGRGDDATGGPGNTAKDSEAVLAAEDGVGDVPRVSLSQLLKAKPLTFENDVRLEKFDGSRLELERSSTKHPWNIKVAFAGEDIIMTKLPPFAPKQLTHPFLRSLHAGPQGEVKWVVDGLNGQDLSVMSRSNKTKALDAIKGSTKLSLVLRALRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZU4</accession>
    <name>A0A088RZU4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_312280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701615.1">
        <property type="nucleotide sequence ID" value="XM_010703313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZU4"/>
    <dbReference type="GeneID" id="22577654"/>
    <dbReference type="KEGG" id="lpan:LPMP_312280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310030100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_312280"/>
    <dbReference type="eggNOG" id="ENOG502SIP7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="258898at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO00815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="221" mass="24628" checksum="EFEFE25CFCD2636D" modified="2014-11-26" version="1">MPKAVQFAVLKQGALESGSWTQRVLTIDTTTDTVTISRKQHSKNLFYHSLEVLHVQMWPRYKACEVAPQFNSLKAKMTLRIFGKQVPVPKMSVEEVTAAEVAAMIRLPSVPSSISLDASLNIERPPAAAPLHSEKLKPRPSAAAASTGDDLCDSWMVRFSSIDSYELAVLLLSNMRNKEGKRKRLFGHHVLTDLECVKKAWNEETKSLKSISDATRAPERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S022</accession>
    <name>A0A088S022_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_340930</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702518.1">
        <property type="nucleotide sequence ID" value="XM_010704216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S022"/>
    <dbReference type="GeneID" id="22578597"/>
    <dbReference type="KEGG" id="lpan:LPMP_340930"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340015100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_340930"/>
    <dbReference type="eggNOG" id="KOG1164">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10256129at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14125">
        <property type="entry name" value="STKc_CK1_delta_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000635">
        <property type="entry name" value="Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="11"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="307"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIO01718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="354" mass="39945" checksum="8C3C2627A1F5BF9F" modified="2014-11-26" version="1">MNVELRVGNRYRIGQKIGSGSFGEIFRGTNIQTGDPVAIKLEQVKTRHPQLTYESRFYRILGSGGGAVGIPMMFYHGVEGEFNVMVIELLGPSLEDLFSFCGRRLSLKTTLMLADQMISRIEFVHSKSVLHRDIKPDNFLMGTGKKGHHVYIIDFGLAKKYRDPRTHAHIPYKEGKSLTGTARYCSINTHMGVEQGRRDDMEGIGYILMYFLRGSLPWQGLKAHTKQEKYNRISERKQTTPVELLCKGFPSEFAAYMNYVRALRFEDKPDYSYLKRMFRDLFVREGYHVDYVFDWTLKRIHESLQEQQSFPGGSNGGGAAGNGSPMNQSPAPGGNGGAPNNVNNNQELGAPEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S116</accession>
    <name>A0A088S116_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_343380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIM50 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01964.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702764.1">
        <property type="nucleotide sequence ID" value="XM_010704462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S116"/>
    <dbReference type="GeneID" id="22578843"/>
    <dbReference type="KEGG" id="lpan:LPMP_343380"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340040300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_343380"/>
    <dbReference type="eggNOG" id="KOG1605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01964.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="506" mass="55787" checksum="FD5AC212EB161D11" modified="2026-01-28" version="2">MPTCSSATVTGESRSCACAVLPTIPVRPPLPRATMLGRAGNTCTSAHPRSLREAAMPPRGDAPRCARQRHCLTHDTTLSHPRKDADRAQAISGINHSSSLNSTAHWPLLGKRGCSLWALSPATQRRSSPAPAAAPEAVPLRPPHPPRSPPYALGCDRGRSSDNDCSIFPPPRALPLYTTEEELPVCIDPEGVRCCPLLNPQCEEGVVTAAQINLSPFLNWKFVPYLPPQAEDQARSTVVLDMDETLLHTSVAPMPDADAEIDVPYPSDDARDVKASVTLPHYKLFVKYRPHLEQFLLFCLDHFEVVIFTASKALYAQAVLRQLQEDFPGIAIRLDDNNLSGGAPASPHARGEARIIELLHRDHCTPTNVGYTKDLHLIGRDLRRTILVDNRKVCGVFQPYNAVHVKDFARRRCAERVPEEQKMQAMHLRQLERTIPASAVEVAEDVATSRLLSTSGCSTSTYDWEDREDTVLLHLCAPGGLLHCLSRCEDVPSFLQRTMRFNRAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1F0</accession>
    <name>A0A088S1F0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">U2 small nuclear ribonucleoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_350540</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702993.1">
        <property type="nucleotide sequence ID" value="XM_010704691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1F0"/>
    <dbReference type="GeneID" id="22579083"/>
    <dbReference type="KEGG" id="lpan:LPMP_350540"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_350540"/>
    <dbReference type="eggNOG" id="ENOG502SARU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6425924at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000058">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="5">
        <location>
            <begin position="11"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="107"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO02193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="141" mass="16316" checksum="CF252116011EAD2D" modified="2014-11-26" version="1">MTDTSNCKEDIPSSVVFEALHLRVTVETVEGDLYKGKLADFDVSRGNIELVDVRHQAKDSTYRFYERVTVRGSNIRIILLPQEMKAAPSLQWRQDSVQQDLTKSLKRTHFLRSVMPPPRPVRTKKGPPKNDKSKQLRRKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1H1</accession>
    <name>A0A088S1H1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase C2, calpain-like, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_350810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703018.1">
        <property type="nucleotide sequence ID" value="XM_010704716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1H1"/>
    <dbReference type="GeneID" id="22579110"/>
    <dbReference type="KEGG" id="lpan:LPMP_350810"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350013700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_350810"/>
    <dbReference type="eggNOG" id="KOG0045">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="424753at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF423">
        <property type="entry name" value="LEUCINE-RICH REPEAT PROTEIN (LRRP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="3">
        <location>
            <begin position="451"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="79"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO02218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1131" mass="122316" checksum="C86AB560E919A512" modified="2014-11-26" version="1">MMRRPGVEYCTATSSIHGTLGTPSSSSLLPVSRTSAAENYSSCKSGISLLTGTLSPAPLQTPPPPSSSLFTSGFYDAGNRDVRETKHNMQQQQEVLQQEEEVARLEATLARERVESADSLNVVRASLQRERLRSTMAEQGQQAAQAEAKQLRIALRALLAQPPDSSNIVSSSPMVPVSLYEEARRLLLRCKRAFAELKALQLRATDSAGFQLFHQYDIPVLDEIPPAWPPETPQRCGKEEEEHALDVARGDCSAPSTSASREKVATGTVSLPMEETPIGPEVSVLTTVSPDTPHSTSTETQQLSAVTTASDTAEKWQERVNVLPAHNPSNVVGKPDIGGETVSAYCGRRPRPVLLSPPLPSPEPSVLNTLTPWTGPMHEFAESTTVLSAAASQQLDAMHPPQLREGEEERAIRDADRLLRQWAEKVETLATRQGLRAASEVAALCRRHGLHYIDAAFLPVSETLGLDSGRGCRGYGPGCGTSFVVQWCHRDTVVPRDRKAELLTCAGINPSSLRCGRLGDVGVVAALAALAEATGAVTSVLASTTSEDEENGLYVVWLCMHGWWTRVSVDAYLPCVIEQNRFVALYGCSSTTTPYDLWAPVCEKALAKVLGGYHSLSSLTAEATIGSFTGGPVECWDWWHSRSGTALEEMEAVLNTNARGAGVVLLSTFSTAVLRDTPAKPVTAAGAQAAYQRLGLQPGTSYRVLAVADNAEGDPMVLLRNWTRQCEQQEESQVDLLFDRHAEDSGGGGRCVISPPRDSDDGIAAAERWLAKLPPPSGVAPSHGDSCVWLSYAKEVLPYFDGCHVCFDCRRYHDLRIPIKFSGSRLAIPAQIVRVRVREGAVRPTHGLMRCPTRLWIGLHQPCTSAAHNVAVPGAFLWGLKMTLVGQEEALAPFGGDGDRVRPARRSYVLSESFLGEPKELPAVWMYLELESATDAPPDSATILKEEDTDAPSVTTEFFVVPQMEWIVRKDRAHASQDDNGLGSLGVGAPCAQSRRSVEQDSQLHHISKCAAPCGDGGKYADAVARALCHDCSERHLPSLAEHSFGETTTAIVAVLAEHRELLLVDVVDAPAELRAAVYHDVLDRIDFSDCTLAGGSGRRHISHLSLPGAATEQGEVRCQLNGRCMPTFSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1H5</accession>
    <name>A0A088S1H5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_350860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703023.1">
        <property type="nucleotide sequence ID" value="XM_010704721.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22579115"/>
    <dbReference type="KEGG" id="lpan:LPMP_350860"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350014300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_350860"/>
    <dbReference type="eggNOG" id="ENOG502S7FZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="417078at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005221">
        <property type="term" value="F:intracellularly cyclic nucleotide-activated monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000253">
        <property type="entry name" value="Cyclic nucleotide-gated potassium channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000594">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050866">
        <property type="entry name" value="CNG_cation_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638:SF11">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0407">Ion channel</keyword>
    <keyword evidence="1" id="KW-0406">Ion transport</keyword>
    <keyword evidence="1" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="3">
        <location>
            <begin position="216"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="533"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="540"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO02223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1818" mass="198034" checksum="EA246E0F63A91DF7" modified="2014-11-26" version="1">MRRLRRLFLPVIMRIILRHRRRSRWKDGQPPRRYTPESVVAAIMSTKSRLADCPQQVVESLAVGATFRSLAPKEIIVYANESHVSCGIVVLLHGQLEERRPEEGGRNWKKGGGGATRPISTQTHRLHKAMNILCLMSVMCEDRATSFLATREGEEADVAIISSRWFWEVTYSKTQVPLLTTDVMGRTLREVVLPHRRDMLLADYFPTSAVLLRSWMWSMLTASDRVKLSRSMEVRVLSVGDVLFDEGVYCPYIYVVRRGALTVTVKGEALAVLEAGAAVGEQSVLFHDRRNCSVVAATVCELYALHARHLLHRFLKYPESARRIIAEAKERQRRWMEEGRTRDVFGLVSILSGVPCLGHTTDAMREEIAQCATVLILPQGQTLISTYEPCTFFCVIGRGVVTLTSVIKTAAVAETPSSTSRTGRKGEPQSSGQCVSVAKPIPTPLPEIRREGRSAGDFFGELCLKPHLWPYDVVCDSTVCLWQFDREAVLRVLERNRADAQAIEVCRQGISLFRAQRGEASIVEGFNAPVAPNSVTNGLRSRAGSQRSRAQSADLATSPSGVRNSSAGGRSGRRSSLLQVAATDGSRESPSEDPTLRGGKSVGVDWTPEQWTTYAVTRMQEGLRAEDAKDSPPAPIRDLRDVDKDVERTMNEKVLQLVAVRSDTPPNPADCDISGDSGELQSIIVEQLFLIMTEKQSRFLRQVNDSNVRLITEDDDTQAMGEQSNSLADMSLIDALHNAEAPVEVAEVMRLEDIGTLPLVGNHLLSQRSMPSSSVHDFTDAVDVINTGFVDDPLHVEGAGGAQTGCSMPTAPLGRTRRSTSLCAIGEASAIFGASLSLRMSVSRSHFVRPSSGVPPSPRCNSGRDDLLSPAAIGVTRPMSSSESRVMPPVRTRPTSVDFNQFNSKLSVDRSTSLLDRYVKIEDQNYFDNFVEVLPLQRDEMWAPDEVNTDSEVGAGAMVLLLLHVRKCDYLSAEVMQRCARPIVKVTLGQRVLVRTSVMENRTAPRWPIEHSSFISFVRRGTDIVFSVCDMDNESCIVYQTSLSTASIHENGGVGQQAMSLTELSAMGCPVNTELDAGVKGAQPSGMGRQDAKQPCVTTTMLAVTATKYKALRQYLEAREKAIVHPPLASESTTLFLQVMSVEGLKHRIEAALIVSLYDGTTSRRLLETERVTPKTRSPAWSGEKGFVIVSGEGGILTFDLLHKGAVIGSTEATVDELIFGGVGLRRLPLLQAQTGRLVIGHLVLGVLGARLRDSFENRSRDWVTHFAVEELSLAREGFSINPDPFIVLRDGTGAVLMRTPLAFSAFEASWPMSEASCLLQCPRLRGSTVAYQLEVCDSDENEVIGRATIVLRDGGAGPDHRHDILLDPPGRGVVRLRSLCLPVLELPPRVTALCPPSSSQVQFSESSMLLLLHMTGCTDLPGGASEELQADAIGTFSIDAQPYLRTSLQEATRAPRWPFSKASVLLRIPSQDGGSDAAGEEVNLQQQQQQHRHECQFAVYDGVVDKVSQIGQVAVPLSQLLSSTLHTYPLFPRCKDADKGASNLQPSVSTATRTCVTSERTVGTVQIFTLIGSLGHQMRRTAEQDIGALLAPISAVRVDTAPDQLPYYIPGSAETTTVRASSALAATVVLSVSNMCYVLPSASEKYVHLLVRYGATVLFSVERQMGALSHFEWSPTEASAAVSCASLPPDAALVVELTAMDVVEGRSEMQNDIAPSAIGAEAQSPTKDGNQRDTIANGSVTVDRLSLGHAELPVSRLSSVKTGEVEVVTLMLSGSQSYPSTLETTGRPPRVVPSTGAPGYVQETLPTVSFCIFGNRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1R4</accession>
    <name>A0A088S1R4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine protein phosphatase 2B catalytic subunit A2, putative</fullName>
            <ecNumber evidence="2">3.1.3.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_352060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.16" evidence="2"/>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703143.1">
        <property type="nucleotide sequence ID" value="XM_010704841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1R4"/>
    <dbReference type="GeneID" id="22579235"/>
    <dbReference type="KEGG" id="lpan:LPMP_352060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350026600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_352060"/>
    <dbReference type="eggNOG" id="KOG0375">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5593063at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033192">
        <property type="term" value="F:calmodulin-dependent protein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097720">
        <property type="term" value="P:calcineurin-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043360">
        <property type="entry name" value="PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45673">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="1">
        <location>
            <begin position="42"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="400" mass="44239" checksum="26F5D01E2CB6C878" modified="2014-11-26" version="1">MKCSGVVDRILNGTPVERSLSLKNDKVSLESIMLQFLCGEPLRLEHATEIAQQAALVLRTEPNVLSIGDTVVVVGDIQGQYYDLVEIFAACGSLGVTKYLFLGNYIGNGGFNLECLLFLLAAKVAHPQSLFLIRGSNESKFMADVLQLGKECQLKYSSALLPQLLSAFNCLPLAAIVRKKFFCVHSGLSPDVSHVDDIALIHRFRHIPTRGAMCDMVWSEPDWDTGNQLYNNAEESSGETYIPRLGLFETRALFIPNKQRGLSYVFNFACAKRFVSANNLLCIIRAHEVQELGFKLYRPHPNHLFPCIISIFSAPNYCSSFGNKGSVLVVSQETICFKQFEPSPHPCMLQGRNAFSWSLPFLESNLMSIFLTLLSGSDYDPMGVDSSEKGSSSGDITPII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1X9</accession>
    <name>A0A088S1X9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ATPase alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_050490</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="AIN95491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703813.1">
        <property type="nucleotide sequence ID" value="XM_010705511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1X9"/>
    <dbReference type="GeneID" id="22572127"/>
    <dbReference type="KEGG" id="lpan:LPMP_050490"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000023700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_050490"/>
    <dbReference type="eggNOG" id="KOG1353">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="274756at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1-ATPase_alpha_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000002">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12240:FF:000004">
        <property type="entry name" value="F-type H+-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a_nt-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082:SF2">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="11">
        <location>
            <begin position="176"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase alpha subunit C-terminal" evidence="12">
        <location>
            <begin position="406"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIN95491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="574" mass="62616" checksum="23DAD102F4C88EF1" modified="2014-11-26" version="1">MRRFVAQHMAPAVARLASTAAASKSAAPGQKSFFKATEMIGYVHSIDGTIATLIPAPGNPGVAYNTIIMIQVSPTTFAAGLVFNLEKDGRIGIILMDNITEVQSGQKVMATGKLLYIPVGTGVLGKVVNPLGHEVPVGLFTRSRALLESEQTLGKVDAGAPNIVSRSPVNYNLLTGFKAVDTMIPIGRGQRELIVGDRQTGKTSIAVSTIINQVRINQQILSKNAVISIYVSIGQRCSNVARIHRLLRSYGALRYTTVMAATAAEPAGLQYLAPYSGVTMGEYFMNRGRHCLCVYDDLSKQAVAYRQISLLLRRPPGREAYPGDVFYLHSRLLERAAMLSPGKGGGSVTALPIVETLSNDVTAYIVTNVISITDGQIYLDTKLFTGGQRPAVNIGLSVSRVGSSAQNVAMKAVAGKLKGILAEYRKLAADSVGGSQVQTVPMIRGARFVALFNQKNPSFFMNALVSLYACLNGYLDDVKVNYAKLYEYLLVNKDLSVMYGTATNKFFYMYVQQLNYVIRFFTLSHPVLNAEVEEMLKQHTHLFLQHYQSKMNAIKTEKEIKALKNLLYSCKRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S240</accession>
    <name>A0A088S240_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_353310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703268.1">
        <property type="nucleotide sequence ID" value="XM_010704966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S240"/>
    <dbReference type="GeneID" id="22579360"/>
    <dbReference type="KEGG" id="lpan:LPMP_353310"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350040900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_353310"/>
    <dbReference type="eggNOG" id="ENOG502R20P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268989at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="307" mass="34401" checksum="0D93EE9FBEC99E74" modified="2014-11-26" version="1">MDSLYFISKAQFHQLATHISLYHEDMSAGYKHLSTDALMAVGLKPHKFTYWNVPMMSGYLGKTVPLDIHGGYVMIDEEKVMPMATSYGMLRYALLTSAVRAKEGGRWRYDFMTMNVTLAAGSAAGFGLLSFGRKRIGWMRHHPIGSVMVSFAACLTTTVIARQGIKELGIGIVQAQNSHKKALNNLHCVDCLEDVNTYTLNQIEELKAQQIPQQPGMPPPPEEYVKRFKKGVEMQCKLLETDMDEVRLIRKWARGSLCDVHQHLREDPTGYKEPHGIALLASDHARAAERPPLATEPDDAKRTSAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2M8</accession>
    <name>A0A088S2M8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_070200</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP009376">
        <property type="protein sequence ID" value="AIN95706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704028.1">
        <property type="nucleotide sequence ID" value="XM_010705726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2M8"/>
    <dbReference type="GeneID" id="22572355"/>
    <dbReference type="KEGG" id="lpan:LPMP_070200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_070006900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_070200"/>
    <dbReference type="eggNOG" id="KOG0589">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001566">
        <property type="entry name" value="Protein_kinase_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="28"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="606"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="920"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="606"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN95706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1059" mass="114379" checksum="E2E98092CAD5F518" modified="2014-11-26" version="1">MPPLSLPQRRLPKQPPPKAQNTMATSEYRIMEKMGTGSFGVVFKVCRVTDHQVFVMKRIPLLGLTTPQRRDAAQEIILMRDLHHPCVVSQRDAFLFNEHDLCLVMDYYDGGDMDTHMAAQRELDMYFDLDQVMLWFVQLVLGAQYLHAHNVVHRDIKIHNVFIRSRDMSVVLGDFGISERLGADMTSHTWATAATMGGPPGSSSSSFISAPAVGNGAPVGSPSPLRMNDGDDKVPSLPISGGLYSPTPVAAEAAAAPPFPSLYQQAPWSSGQWGAESPLYSPKLSPYEPLVHIRQMSTSSNAVSSCSPGSQRRRLHSGVDGVDAMEAAMKGTPLYMAPEVLQGGAASPKSDVWSLGCVLYELLALRHPFESRDLAPLVMRVLRGQREPLPAHFPRPIADLINRMLCLDAGQRPSCEEVLTVPCVRAYVDLWRSLRTPLDVPSSPSECALTRQLQAWQENIAAWNARHPGDPRGKSLHYTELRRQLLSPACAPAEEHENAERRAVEAARAALLTAQPSGLIGSASLLGMGGGGAHDGIFYGATGERLVGAAGGDLQSIPSSREGAVGMAPSDSMRPYMLYDVAPEPAAGAARGAAGLADAKAAAGKAVDGCPSMPSRRPSGSPSPCPVQAGDLAVTGHKIGNGRNPFGLPPPPTDATHSEDSPIGSAAVGKRRHRQARQRESATPQRNAKSVRHNGKTEPKGKLSNGAASPAIDGFAAVPTTSPTGSLRSFQLQRGFSASLPPLLREHGTALGGAIDEDVAFFRAYHNVSDMRCASLEEIAQAVMELRQRVQERLRHQRVLTDIEVLHERHGSALLRSMPHVLHVLEVAAAAAAAGEGHGDPPAGAQPWMSPEGVYVDMVRQIDEQRSGRERLQLDTGSEERVAGISYAEKLPVGRPMPPRIRELREAAALAQAAASEEARRRARLLPSESRRDSTCAQSSGVSSSSAVSMRFADPAAPLMVASTDGGRSASRTAAAELRRWRPYLERRNRLSAELTGVFDATTLRAVYSYYRTCALLQRDATVVRRLVPDRQQWTALPSIEELAVLDRQLEGVLEKQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S325</accession>
    <name>A0A088S325_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cullin family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_343620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702785.1">
        <property type="nucleotide sequence ID" value="XM_010704483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S325"/>
    <dbReference type="GeneID" id="22578867"/>
    <dbReference type="KEGG" id="lpan:LPMP_343620"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340043700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_343620"/>
    <dbReference type="eggNOG" id="KOG2165">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5581181at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044554">
        <property type="entry name" value="ANAPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057975">
        <property type="entry name" value="TPR_ANAPC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45957">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45957:SF1">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25773">
        <property type="entry name" value="TPR_ANAPC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cullin family profile" evidence="2">
        <location>
            <begin position="511"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="898" mass="97888" checksum="680F1A3FFFDCD6B7" modified="2014-11-26" version="1">MNCASVPVSLAQAASAVLASSAPSRTEQSLHSINEEDAMFILAEMLDALDTHGLALFVESGRGAPCPLPSPRTWSAALVALATSAPLNVMVADALLDRVSAALSVEIGVYHSAVLCSSGPLSAEVALPALERLDEVYRQVYSHLLRWCSALRAPGVAALLAVRLRCALLQTDLVTGEEPPGRRALFSFLRRHGQLVLATQRRATGNDGDDNVDDLERDGALKVAGDAREGSPAPGSTLPAPDSLMACLHRLGLNQSAEVKQLWRSVLEDSIRDRLRDLSDDFSTRILHKQLSWLEHSVVPFVRMVLSDSDGGSDACCHSSGGFTGTSMIHHGGDVGGMSRDRHTVTGCEEAGSMCVSSQTSEAVRAEREAWRADLRLLLLHTYARRRLDDFWEILSDYPESVPALEDMHYCLQSTPESGLKTELVQTVRHLLSSRLHRAGTRTEDILAILINTIHAFCILFPRNEQSSVVFVTSDTLEHLRRRKDCVPAVVQAVMQPGGAMNALPPPPTQAPPERLAGGLDLCDYSASSKERELHRASRDRPDVVRVLLTSIPRRALVDEYRQMLAEQLLQKPMHEFDTTPEEEVLERLRHVFGETALDRCAVMVRDMQMSRRISQQLREQLAGSRAGCSRRLRGTTAFATTAPSAASVSVLSMTTWPPLARCSSTNGGDSGPAAAPLKYSPHPSLQAQMDALAEAYKRLKDNQRLTWLISLGRVELELTQKDPSKGNALTAVPQVLSLFDASIVLHVKDMTDRGGVCTPVSLKDVANVMEVQLEELRAHAQRLSPAVLVFLPATDLVSMQLSVATSADFVFIEDRGTDEEAGKSTGLSPERVKLMERMVTSLLKTRGAQSITAIHSSLKLLGKFEGSIDNVVELLRSFVGRGLIVLNDARQYALPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3A1</accession>
    <name>A0A088S3A1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Adiponectin receptor protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_355630</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703494.1">
        <property type="nucleotide sequence ID" value="XM_010705192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3A1"/>
    <dbReference type="GeneID" id="22579591"/>
    <dbReference type="KEGG" id="lpan:LPMP_355630"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350065000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_355630"/>
    <dbReference type="eggNOG" id="KOG0748">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="529367at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF52">
        <property type="entry name" value="ADIPONECTIN RECEPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIO02694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="41014" checksum="F27F18685316EDAF" modified="2014-11-26" version="1">MVSCKNGQQASKRLLSSRRGMKASPPPIQRSASWASVPANPMETKSTRYARKQANCEHAKPYNGDSTLPLYMISDVPMYLRDNGYILRGYRAYYTGKQCVTSVLRMHNETINIWTHLLGVLVFLGMVVQLFTQHIIPEYLAGNVFHRENRTATPVHVSGARTRLPFIIFGAFSFSCVMCMLCSACFHTFLCHMSEEFYHRMHALDYYAITLLVVGSFLPFCFYAMHCAPAWRNAYLSMISSFGVVGLIGPFFRHWTSEAFATKKIIFYVCMVGSGIIPTIHISQMIPLDISAPYVKGLLTMLALYGFGVFVYAFRIPEAISPGTFDFYFSSHQIWHVCVLGAAITHFYNCVAMYLNRGTIVCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3G3</accession>
    <name>A0A088S3G3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine/threonine-protein kinase TOR</fullName>
            <ecNumber evidence="9">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LPMP_356460</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="9"/>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703574.1">
        <property type="nucleotide sequence ID" value="XM_010705272.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A088S3G3"/>
    <dbReference type="GeneID" id="22579674"/>
    <dbReference type="KEGG" id="lpan:LPMP_356460"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350073300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_356460"/>
    <dbReference type="eggNOG" id="KOG0891">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016242">
        <property type="term" value="P:negative regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05169">
        <property type="entry name" value="PIKKc_TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000029">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.150:FF:000002">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000965">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000034">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.150">
        <property type="entry name" value="FKBP12-rapamycin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009076">
        <property type="entry name" value="FRB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036738">
        <property type="entry name" value="FRB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024585">
        <property type="entry name" value="mTOR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026683">
        <property type="entry name" value="TOR_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF9">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08771">
        <property type="entry name" value="FRB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11865">
        <property type="entry name" value="mTOR_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01346">
        <property type="entry name" value="DUF3385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01345">
        <property type="entry name" value="Rapamycin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47212">
        <property type="entry name" value="FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 9 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="12">
        <location>
            <begin position="1375"/>
            <end position="1947"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="11">
        <location>
            <begin position="2134"/>
            <end position="2451"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="13">
        <location>
            <begin position="2582"/>
            <end position="2614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2558"/>
            <end position="2579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIO02774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2614" mass="291927" checksum="4222D5F30B64A92F" modified="2014-11-26" version="1">MVSNSGVGSSHGSGGTSSNRHPLIGQLRPIFQELESSAPQTLPSIILKLEYVIEEEKDALFHRNSIKSYTANARIFPNWLNAQLRHLFERPQTHMAGVQVLRALLPVEYVELNEMTKLFSELLVRCVLETGDYKTALEAGEVWGLLLNNGSSVVEGIINNCLQFSLALLMRGGHDEVFLREDVNQRGDDRGATARPGGSPLVDLSRLGKNTPLTDEDLFPEATKLSGCIFIQQLVRRVPSMIAPHVNSILECLRRAILDANKLVRVSGGDALFHTLAISYRSTDPKFYSRWQNRFLEDTERSVLYGSDIVLHGCLLAFNAVLSATALREAEGREVGFSNRGRKHILQFWAFVNDNLVSTSHNGDVRAEVLNALPLLAQYDSITFKEISVKHVRALAEAVFVGTEGTDERAIVFQVLARLFTVLPSLVVPFLDFMMKYIEASLTPHPLRGRCPEAVTCFATLAGVEPNAVRPFLRHLLGPLFAGSVTEHFARDVAKICTAFPELRSTCLSKVLEATKAQLLRMRNRPRHARASSETDHSTIVHNLNSLGSLDFTGYSTLQFLCDAVIRYVSDPHEEVRRSAIDLCFKLVLSGCSQSPCERTDVGVVIHRGREHVGLVNTVIRKLVSAAVADTESDIRLHTLEHLTAEFDYSLALQSICTALFPALHDHHQNRIAATRLLGRLSSRNPSCILPMLRCVMVQCIMDIQLFHAPKRQEQAAVVLSAVVESAPAMARPYISSLLQDCVMRLQEENKPVPVITALLSLVGKLARYAEGNDVAVVAAIRPCVIRHILDSSSIQKKIEAIRTLGDIIRTTKYVDVYETNPELLSVLLSALHGGFKETWPVRLDVLKLMGIIGAIDPVRAKEITRDLRDGGLSSSGAAAPSALQYSSSRGEEAVVQNVVKNVLGVLQLPSLSDDQCLCAVQVIANTLSLKEAASGCLTPMYRDILQTVLQRITLQAKIRENLLKVMARIVYLYGQHIRPYMGELITTCVDFLPAAERGVLVEILCLLSEMRRSLREEFCPSLSLVLPPLLQTVQADAAHSSEPVFAFLVDMGHLLDDHLHNVVPCACEVASNPAYPVACRAAAVDAIRHFARRLPHLVFHASRCMHCLCRVLREMESHPLLFVHQPRGSADTAHRRPVAELAAGGGTAAADVRTFVAVTLDAVRDVSRNLGSDFEKYTPLVFPLLEAYGEDGQEVKLSILSTLRTNGRVAAPESTQEQEAEAAARYRVSTQELTQRRKAALEDNFAQLRSVLVARDRVTEEEWNMWLKQLAVELLRSSPSNAHGFAFALAQLHEPFARHMLHSAFAVCYAEMAPKTKDLVRTLLGNVLRSDRVPSEVLQELLNLSEYMERLEMRFNPKEGSHSTYAGLLFDLKTLMESSERCNLYAKALHYVEIQFYEATYEYERNVMRGQVHPLLPEEWSRLLQWCEKSIYLCNLLGLRESAEGMLKYIQRNFSFLTGKPPSELPLMMDAQLLEKLQWWSQSLRAYEKGLQEEPNKFSNMVGFMRSLDNLGDYGRLLESWKLFHPHITRKEASELAPYGAHAAWLLRCWEDMEKITAYMTDDGYIGTTAVFYRAVLATHKLQFHDAVPLIQNCRKRLDSTLSALVAESYDRAYGLFVGIQQLSELEELAFVSDNPQGLNHWQELWEKRLAAMAYEGWPGTLANHTLVIPLGQELEMWLRFVSLSRVHGRDRTSRDILFELLGKRSIAAALEQPRLPQPPIALATCQHFYDINERERAVELLETYLKKMDQAAPSLPDTGDSQASLAMCHAKLASWLFTVAKKKRHNMDAHYREYIRHHLEKATSLDSTNGRIWHTWARFNHDLVTHRSRGAASDVRRDEHVEHIVAAMDGYVRSVSFSQELEDMLGFLSLWFIHAALPQVQDNVTLQAEILQVSPTVWLKVIPQIIARLHSRDAVVSESVFQLLTIVAKAHPQALLYSLNVTLNSSVRSAESNTVEQMERKQAAQRLLGRIKEMHNNGRMMVKDAALVCQELVRCAVLWTELWFDELERAWFQWGRDKNAHSVLLALQPLLEHLSHPDTLAESHFVTEFGDLLSGACECVEKALSTGNNVYMEEAWNRFKTAVKRMDEQINGMTSLALQLVSPRLIQSGKDLSLVVPGQYNDTGVYPHISSFQSTLKVMNSKQHPRRLYMTGTDGVLYKFLLKGHEDLRLDERVMQLLAFVNTLLEKHSAIQRRDCMIQVFSVTPLSENAGLVGWVDNCDTLHQLIKDYRVHSEYLSIEVNLMLSFNVDLDRLQVIQHVEPFEFALEQTEGADLANSLWMRAPSAESWLDRRTTYVCSLATMSMVGHILGLGDRHPSNLMIHSFSGRVVHIDFGDCFDVAQNRSAFPEKVPFRLTRMLVKAMEMGGIDGLFRHGCITVMGVLREEGSSILALLEAFVHDPLVSWWRDESEDGAVASAVVASAAPSSSMPSIAAPAPLSHYSQRAAYAAIGESFHKSRTAFPSLTPASRLSVPCGRSLHAPQASVASRVRASPPLVSSSQSSDILSNMSVNHTSEAKKVVNRIREKLEGREFAGWQLQANALSHAAGGVGVAMKEGAGEEPMTSARLGSDASAAPMASGEDGLSVQAQVTRLISEATSNENLCVHFQGWCPFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3Z6</accession>
    <name>A0A088S3Z6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_100710</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696794.1">
        <property type="nucleotide sequence ID" value="XM_010698492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3Z6"/>
    <dbReference type="GeneID" id="22572808"/>
    <dbReference type="KEGG" id="lpan:LPMP_100710"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100013500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_100710"/>
    <dbReference type="eggNOG" id="KOG0272">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF744">
        <property type="entry name" value="DYNEIN ASSEMBLY FACTOR WITH WD REPEATS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="91"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="133"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="176"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="218"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="260"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="302"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="344"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="386"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN96141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="419" mass="46123" checksum="BBC1016E563C52BC" modified="2014-11-26" version="1">MKLRCFLLRYYPPGITLEYETSAGLVGQKTIGLLSLTPTTPLEPLVDKIIAEEPLLNGKYRDQIFLYLQRLVEKLIAGNNPSQTFTLFKSLRAHMLPLTNCAFNKNGAKFVTGSYDRTCKVWETATGSELVSLEGHRNVVYCVGFNNPYGNRVATGSFDKTCKIWDAESGQCLHTLTGHVTEIVCMSFNPQSTLIGTGSMDNTAKVWDVETGQCLQTLMDHTAEIVALNFNTYGDLIVTGSFDHTAKLWDVRTGTVVHTLREHRGEISSVQFNYASNLVVTGSIDRTCKLWDISSGQCVSTLRGHTDEVLDVAFSVSGNMVASASADTTARVYNTATCHCIASLNDHEGEISKLEFNPQGTKIITASGDKRCNLWSVETGQVLQSLVGHTDEIFSCSFNYEGDTILTGSKDNTCRIWKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S443</accession>
    <name>A0A088S443_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_110150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696864.1">
        <property type="nucleotide sequence ID" value="XM_010698562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S443"/>
    <dbReference type="GeneID" id="22572880"/>
    <dbReference type="KEGG" id="lpan:LPMP_110150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190006600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_110150"/>
    <dbReference type="eggNOG" id="ENOG502SJZV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267562at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053095">
        <property type="entry name" value="Actin-binding/GATA_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23246:SF13">
        <property type="entry name" value="GH12359P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23246">
        <property type="entry name" value="NEW-GLUE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="683"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="851"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="473"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="683"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="695"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="883" mass="94153" checksum="48400713FC825914" modified="2014-11-26" version="1">MDLDDIDRWYSGGSSRDHYRSHYASHYSRKWNDTHQSIHNPPLPRRYFNDDPIPEKLPSHRSAPPPPPPPSPPPHRSNSANVKRKNKRHSKHRHTRRKRSASFTSSSAARTETSRTSSTSSTDSAESTTTSSSSSSGSTASGSGSYESSDSERTSSTSASTSSTSASSTSTSSSSTASSHERRAQLHKKVKPHLQQSAVALSRVASRPYIAVQDEEIAAAAACKAIFNKEVQLKEEELRLLQQKRNFAAEVQRRSLHSHRFAVEDDAIRQMQRLVDLTDTTPALEEYLRRTSKALSASGATTDAGALAYLRSYEEALSGDGVAPLLKQMATPPSTSVAAAANARRDERLAVVGDGPPAPISLSSGTPKIEPLAATRSIAAAAPTASGGVLPHRTSPEANSLLEHSLPVEGHFLTRSAPPTPTGRAMAQAPSQGAPVLSITTDAGNTENGVVVGGAPAEGVITVAKDERQGGSAAQATAKPAEPAVSRPLKGDLVIHNDLPQQRRIKVKARRRRSRSRALAHQSEADRNSALEDAPSSNERREDSTVSPSVGHSRPGRQQQPIGASWQLLPPPPSPASHTVAEQQHIFVDPMQQYNSQSGAGQQPWAMVNWPCNAPTWRPTHKEKDGPLALWYASNSPAPLSHRDFKSLLCSEYVSPETMPALVPRAVGATAAGVDADNQVSAAPAGAKAGRNAHTPYSTGTADTATLSGETDAGEHAPRRSSRRRLVHIRGVDETPEYPLVAEWGHGEGDSQAHGPAEVLPPPPVDPRGNGNELIVEFPPPPHITASDMPPPGDVGSDVENSCCGCGGGECDCCSAFCARCRRCWYIVFSCLFPCCSGQTNPKAALPIESQRTLSSQRHDPDSALPVLSRPIPTTPATMNAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S4H0</accession>
    <name>A0A088S4H0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_353900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703325.1">
        <property type="nucleotide sequence ID" value="XM_010705023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S4H0"/>
    <dbReference type="GeneID" id="22579418"/>
    <dbReference type="KEGG" id="lpan:LPMP_353900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350047000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_353900"/>
    <dbReference type="eggNOG" id="ENOG502S2QM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264536at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42180:SF4">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42180">
        <property type="entry name" value="HOMOLOGY DOMAIN-CONTAINING PROTEIN,PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="6"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="599"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="844"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="693"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="611"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="844"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO02525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="957" mass="103184" checksum="27EE228FA7829270" modified="2014-11-26" version="1">MSESKLIGKAELLAWAAYTTGISPCGTYKDLKDGLIYLALARQLFPGEIDNGFVRLQRRGARDATKNWSLLTSCLRRHGIPTHLCSRQAVERGHTRHCFNLLVLFYFLVRLARGDQFAVNFAQPVDPELAAFLQSPESLLAVDSTVDVGFGKGSTSSVRVPAVADTEADGRADSGVPLSLTRLSFPSSVASVSTTAAQVAPMALPHCSTSLLADNSSTHLTPLPQRTWACEWSLTRTPSDAAVWRAPHNNSSRETEDLKHFPSAAYHSTLAQGVARAPAPCGGELATAPLSPPPPLLCPSPFTTHTPHLYRQNQLLREELQHVKAFSQLLLEQKRGLEVAAEMRASAALREQLAKAELNHLRHVRQVEATLTAASVQDDGATATPSPQQWAALAHRAETAEATAGQLYRECRESQQAYDSALQHLRQVFCTITDIAAAALSSGPSTSAYAGADAYEETVTAAMMAQLTGAPPVLKDAFHAQLQALLLALASLRSTNARLQQDAASGPPSRHFDDAGRDCAPSLSALHASFLPFVRESLKTACTEARSACQGASPDVQYALQRLTHIVDVLSSDLDAVQQDEDRSEQRCRRAKTTTAQVSAASQRVCAEGETQGQQVSNTRAADLSCLSQERRARAEQSLQENQRLSRQVQEVLTMAFSPHDSHSMQWANDELVALLGAYVKARTPYPAMEEALAEQAETIATLLANLRQQREARERAEAQLSDDEQRRQVLEHKCAALQAQLCSATEKLDTQRCDSKACATAPHRAQRDKASSSSSLTALAIAPLAKLSTIATHDAEKHMAVSDTALLAYSSRHVSSTPNRGTSHALYSSPHLPGALRSLATSDDHVDDVGERRPVDHQHGFHTDLHHHHVSPSSFPSASLSLSSSNVATAGADVPNAPRTEQAVVGACLAAPTTSQVRSTRLSTDPLAAVSGPSLLLSAAELERRKQAILRKYDMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S8D8</accession>
    <name>A0A088S8D8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_203720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698573.1">
        <property type="nucleotide sequence ID" value="XM_010700271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S8D8"/>
    <dbReference type="GeneID" id="22574583"/>
    <dbReference type="KEGG" id="lpan:LPMP_203720"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200043300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_203720"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="116" mass="12999" checksum="A0A0964B240E7BF8" modified="2014-11-26" version="1">MNAFLNLAGSPQQLLLETRRAEAKATQVKEIFDRATLCFEVFHGLKEHNYATQLIMRCQLCKKEVHNLHSLGDLVFQEPVKASISELKVILPKCICTTSRHDMSACECAGMNSAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SAE1</accession>
    <name>A0A088SAE1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cilia- and flagella-associated protein 53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_231730</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CFAP53 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699328.1">
        <property type="nucleotide sequence ID" value="XM_010701026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SAE1"/>
    <dbReference type="GeneID" id="22575378"/>
    <dbReference type="KEGG" id="lpan:LPMP_231730"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230025300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_231730"/>
    <dbReference type="eggNOG" id="ENOG502TBYQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="75950at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043596">
        <property type="entry name" value="CFAP53/TCHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043597">
        <property type="entry name" value="TPH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31183:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31183">
        <property type="entry name" value="TRICHOPLEIN KERATIN FILAMENT-BINDING PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13868">
        <property type="entry name" value="TPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="2 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trichohyalin-plectin-homology" evidence="8">
        <location>
            <begin position="132"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="191"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN98621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="490" mass="58682" checksum="DD5ED85C44E8396A" modified="2014-11-26" version="1">MPRGLIGLSFIEARQRRESFMEKFTAEQTAQNRQKHTVEWELRGNERHEQKEVLEYMDVIQAQHNDVLIARRRRLAELLARENALHTSMMTGLPETDAQRRERLIRKAQELRAKREEAKRVDIDACHDRLFRAKIDCLRQAESRLKVMQVADARYEQIDAVAERRRQDAAEDEFYAQQAAEAQRVATERVQRDLELKYTRKQRMIEDLAAQVEGNRQRKEMEKEEAARDTEEFYRLLHEEQAQETRKRLQRQEKNRQLAQEMMEMNEELKRARQQEYEQLKKEDREALDATLAALAAEQQEQRAEKQRRVAAERQHMLELQQMAQQKGDKDALDKLWAEENEKQWRKREAQWEAEQAKRDALLRSVLIARRQQILDKRQKAQDDAMLRKLANEEFLASLSKDRDIDAAERARRMTLLKETQQYLEWQIQQRMVEKEAARLARRTELTDEQALEKQYEERIAREMANLEAAKPERYRNVPLLPKKSRNQIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SBJ0</accession>
    <name>A0A088SBJ0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA splicing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_251780</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699748.1">
        <property type="nucleotide sequence ID" value="XM_010701446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SBJ0"/>
    <dbReference type="GeneID" id="22575826"/>
    <dbReference type="KEGG" id="lpan:LPMP_251780"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000034700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_251780"/>
    <dbReference type="eggNOG" id="ENOG502S5NJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10263346at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF9">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="5">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN99041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="130" mass="13786" checksum="6765C8D474E0FF36" modified="2014-11-26" version="1">MLSQYLRKRVSVVTVDGRNLVGVLHAADQLLNIVLTSCVERTGAPYDFNDGVPGENNGVVDEGTSTAGSSGNTARGALPPMEEVQLGVMMVRGSDVVTIAAIDVYEEAGTNIKDWRGRDMPPAAAAVRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SE42</accession>
    <name>A0A088SE42_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_290760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700684.1">
        <property type="nucleotide sequence ID" value="XM_010702382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SE42"/>
    <dbReference type="GeneID" id="22576840"/>
    <dbReference type="KEGG" id="lpan:LPMP_290760"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290011800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_290760"/>
    <dbReference type="eggNOG" id="ENOG502S6Q7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264281at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="22612" checksum="459C00AB861390A2" modified="2014-11-26" version="1">MPRSNSGADLRASSAGDAVKSAQGTTSRVQELFRAGRRNPEKELGIPLNELERRQSKARKTRQFVSENTSRTFDVKSSTRAQQIMNRGIDKYQREKRQRDLRSNLSMLRKLQVVLCVFGAGFFGWLSMAYLLPHYFAVQDRHRRMQLRYERAQQSLEGISDSDAAAAAGSASGRAAVPPVGPVVRVFRVEDGGEGAMRHTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SH81</accession>
    <name>A0A088SH81_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NOL1/NOP2/Sun domain family member 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_322570</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a cytidine in rRNA + S-adenosyl-L-methionine = a 5-methylcytidine in rRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61484"/>
            <dbReference type="Rhea" id="RHEA-COMP:15836"/>
            <dbReference type="Rhea" id="RHEA-COMP:15837"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74483"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701942.1">
        <property type="nucleotide sequence ID" value="XM_010703640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SH81"/>
    <dbReference type="GeneID" id="22577998"/>
    <dbReference type="KEGG" id="lpan:LPMP_322570"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320031800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_322570"/>
    <dbReference type="eggNOG" id="KOG2198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="427002at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031167">
        <property type="term" value="P:rRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000661">
        <property type="entry name" value="NOL1/NOP2/sun family, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808:SF3">
        <property type="entry name" value="5-METHYLCYTOSINE RRNA METHYLTRANSFERASE NSUN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="12">
        <location>
            <begin position="87"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="179"/>
            <end position="185"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIO01142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="423" mass="45902" checksum="54A3E1DA46B3C6D4" modified="2014-11-26" version="1">MPSSRGPGRSRNRAGVVPTACPKGVFKTKSCTKPRTFDEYYSDIYGERWPTLRAAMMEGPRKVALWNRFSQVPFEEATRGLSRVDPNSLIQAFQPPQKTNSAEASSMADRGIHVNNEETLREEEVLAAASSDPLHQNGIIAKPPIDAFGIKAYYLLDYASAHVVEQLQVGAFDTVLDMCAAPGGKSIAIAQFLSPDGALTCNETRADRCARLRRNLQEHVPVNYVPWRTTQRDAQTWYDPQTFSRVLVDAPCSSERHLLQQSGGLPLSCREWSEETTVQLAALQRVLLQRAIETCCVGGRIVYSTCSISPLENDGVVGEALQRARCKVRIVKTSSSVTAAAESSVTPSTTANGAGESDASCAGACVSPTPTVLGEATAYGRLLLPDTCHGWGPMFFCVLEKMAEHKCMASTSSEDEDAASVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SHY4</accession>
    <name>A0A088SHY4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">AAT26</name>
        <name evidence="7" type="ORF">LPMP_331500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702242.1">
        <property type="nucleotide sequence ID" value="XM_010703940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SHY4"/>
    <dbReference type="GeneID" id="22578303"/>
    <dbReference type="KEGG" id="lpan:LPMP_331500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330021100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_331500"/>
    <dbReference type="eggNOG" id="KOG1305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28208at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF649">
        <property type="entry name" value="ACID TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="454"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="12"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO01442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="485" mass="53263" checksum="AC8D4F88CB648532" modified="2014-11-26" version="1">MVSCKMISLSSGSILGASLSLAVTTMGAGILTLPSAYADAGVIPATLILVSVGIITVFSIDYIILSVDKLGRNSYEELTRELLGKKVEEVVRWMLIIYNTGSAIGYLVVFEDLVAPMQPLITSYLPLLTTPKHSLLSFWAVAILPLSCVPTLGALHISSFLAISATSFICIIIIFRYFVPGPTKLSTMTASAMTIDTASANWCWGKDPLLALPIIMFSFDCQSLVFQIYAGLDDMRRSVMVKVAIISLIVSGVIHASVGLFGYLSNPVDVRDNIISNYDPNVDRLFKVGYILYATPMILAFALMMFPIRDSIFILWYGYSSASVATHVPRSKDFTRLVNQEEELELMVSAGNEHQYKYCNGFAEKHNYGSAQKELQHVIEAKKHHNKIEQILLRDHIIISVTLSTLCVAVALLVPGIVSVVSLLGGLCSSTLCFIVPGLYRWQLHNKNIAPCQTFWEVVLMTFMIAFGVIAAIFGTAVWIKSIFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A561</accession>
    <name>A0AC62A561_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha tubulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1320210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="XUY36992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="451" mass="49683" checksum="3D47FCCC1FBC5BF5" modified="2026-01-28" version="1">MREAICIHIGQAGCQVGNACWELFCLEHGIQPDGSMPSDKCIGVEDDAFNTFFSETGAGKHVPRSLFLDLEPTVVDEVRTGTYRQLFNPEQLVSGKEDAANNYARGHYTIGKEIVDLALDRIRKLADNCTGLQGFMVFHAVGGGTGSGLGALLLERLSVDYGKKSKLGYTVYPSPQVSTAVVEPYNCVLSTHSLLEHTDVATMLDNEAIYDLTRRSLDIERPSYTNVNRLIGQVVSSLTASLRFDGALNVDLTEFQTNLVPYPRIHFVLTSYAPVVSAEKAYHEQLSVADITNSVFEPAGMLTKCDPRHGKYMSCCLMYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKCGINYQPPTVVPGGDLAKVQRAVCMIANSTAIAEVFARIDHKFDLMYSKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGAESADDAGEEDVEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A595</accession>
    <name>A0AC62A595_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ama1 protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3020040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="XUY36954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="155" mass="17452" checksum="8F2ABB443D0AFBF1" modified="2026-01-28" version="1">MSGKDGNHQNSKTVGTTGHNAVTNRGSWRFSLCVCCSECDSCCESWCCMPCQLSRQCNMLVNNRKEIHCPYCLLMTFCDYTLFIFSVSCIFASETRRLARERYGISGSSCEDCCLGYFCRPCSTQQVLLEMTLMNEFPGATCYEVTSHPAGRRMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5F7</accession>
    <name>A0AC62A5F7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histone H3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1620210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="XUY37032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="66" mass="7238" checksum="D87F239EB5F19D1A" modified="2026-01-28" version="1">MPCARCRACRRRGGPALPEQRDPGDPGGVRCVADGCHEPGQHPREACVTVRPKDVQLAVRLRGERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A697</accession>
    <name>A0AC62A697_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATG8/AUT7/APG8/PAZ2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0920170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="XUY37334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="124" mass="12747" checksum="547644016555283B" modified="2026-01-28" version="1">MSAYVSSTPLEARVARCASLRATNAVPVVVEEAQARGGKAHFSALPRETTAAQLVAAVRAFRGVAANKPVTLTVAGCSVSPSATLGELHDACKQADDGMLYVAYTAERSMGAAVCTPCASCSWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6D2</accession>
    <name>A0AC62A6D2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amastin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0820290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="XUY37309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="313" mass="35156" checksum="C7AEDDC2E46017D0" modified="2026-01-28" version="1">MVCNVAAVLYAVLQFIAFLAVLLGTPIDMFRMRGESIFSNTPCETLWGSKQMCYSAVYNATVADFLQKCPHRFLIFRFAEVFVLISILVYGLAAFFGFILLCCCSCLRWVCLTLNITGIPTLGVVWVSMVLVYYQDDDGCEKKMKNSVFGLGFMLLLVAWCLDVINIIFLVIPWPARDRGESRDRSESRDPSKSRDPNESRDPNEGRDPNEGRDPNEGRDPNEGRDPNEGRDPNEGRDPNEGRDPNEGRDPNEGRDPNEGRDPNEGRDPNEGRDSNEGRDPNEGRDPNEGRDPNEGRDPNEGRDPNEGGEPNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6F1</accession>
    <name>A0AC62A6F1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amastin-like surface protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2021100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="195" mass="21821" checksum="4422187F17640540" modified="2026-01-28" version="1">MEFNPFIIVYAAIQFIAFLLVLVGTPLDIFRSRQRSIFNETSCVLLWGVKRNCSSIAYAATSDDRWVMCPTRRTHFRVARVFAVITIGVYCAAFVLGFIMLCCYACLRWVCLGLNIVGFVTLATLCALMVVSYETDAYPLCPKLKNDFTLSSGFFLFAAALCLDLVSIAFLFIPWSHENVEGSSSHSKEGNSQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6G9</accession>
    <name>A0AC62A6G9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycan beta 1,3 galactosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0220040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009371">
        <property type="protein sequence ID" value="XUY37389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="812" mass="90357" checksum="E369B5843298FA81" modified="2026-01-28" version="1">MWMSSEMGTPGGSPTSAMPFSGPPLSCVTSLPRRCTGFFRYSATPNCTAPRSPKLKRGDAGGSRPPPQLWRLVERVRLGAARLWGRLLGMRERPMHLLMCVALCVILVVVIWWLSMWCRRRHPLSEEQLARLLGPLSKPWSVLVQHEGAVDRLSKVILVEEWLARCSSRGTPLTECNEPLLLSPHMLPAWTLHVVEEDCADCTDQQTYASAVEGVVLQARHAVFATSAAPLGRVGPMLLAMASVTDDVDVRAELPQWEWLRHVHGSGFPAVGGAAGVSAPPRAPYLAVMGIPSTDQRPRAALREAQRKTWLAYQEVARRDNHFTGALLALYVFAAAEPMVPVDVASDEQTRSATMKGYAQDNASSTPFHHTTALLPSLREYDAASCVLATGNTTGDCVAEDFAPRRVVLRCGWQSADTPSPPCDRVFRTSGSSEGAPTSALSYLSGALSLPVTPAFTSPAEYICHASSALWQEALTHRNVLWIDMMTDRRPTTKKKLGETDDWGLPVEVGMSQKLILWLAYAYHAFKDVPFIIKGDDDSYMKVPQFLSDVRYVMSGMQARPPPPPADAANRSTYALDMGRAECMYWGSLRLFGQLTYNSGLLFMLDRLLARVVLEPHPNGEPTTAVLLAVTDFDPSLSRAYYTFVYHHEDILLGLLIRNALRRARDICPNNRVWFIKEGLARFHDLYRGTPHDVTWSTVVAHRCTPANNYYLHHFFQREHYATLASSGGKRRAERAAVVQAAEWVAEHRRAMGPEVVGWDTMPAVQWVRDVERTPAYDMAEADGVPVYRIEYKYWAHQFTAVDDGLYSLPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6V2</accession>
    <name>A0AC62A6V2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SLACS-associated protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0220200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009371">
        <property type="protein sequence ID" value="XUY37405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1015" mass="109920" checksum="5E2E3D58815C0E76" modified="2026-01-28" version="1">MYPDTAEQEEEDTGSAPRSAEPRTETHTPPTQPPGTEGEGEENDTAESANTEPDQTVEDVSQTSDEARHRFHHGENTAAQQTGTIHCPVCPRTWTSRARRQQQTSHLNTTHAREVVRVDALKATGVDRCLSCGEFVIASGNARRAHGQKCGEFVTRAVRNQKRARTEQSTPRQDAVAEPTPETPPPPTRHRTRPTEADAEWVQEFPATIRTLRKQEWGHWAEAVGHTLLGYTAAAAAGRYQRQLALTELVRTRLAKPRAPAREEDESHQEEPSETPREGGRDEPYTGHAGATRRANTEEHLPTRDAHTAEERRARRILHQLSLGAVGKAARTLFQAQLPRARQRGTGSASHASPAGRPSGVPVPTADAFSPRPKAGEGQERGAETARPSRRTGARRMDPGTARSRGRKCGAPGGDDRTDARHPRRERVGVLRVPPPRVRRPPVPERTGIAEGPANHAGVGVAENRLAPRTGRGGKAVPRHLPGVAIRGVGRRRRGGHPDPGDVRERVGRHARRAGRDQRVQPRLPRMGAEGGVPPPRPPPHGWSGGPFPRRTGRPWRLRGRPPGRTTLVDARRPPGHGAQSLLFATAVAETLRPIMAAHPLAKVTAYLDDLTVVGPRAAVQAFLDEAGPALAATGFDINPAKSHHLSKSAAPEPVSVAGVVVPLARGVVRILGAGFRGSGAPVDEWVWEKTRPYEAYFTALGGDELPRHARMNLLRASALPRLTFLLRTHSTDELRDSAAWFDDRVLHTLSVLAGGAPIEDAAALLARLPPCHGRMRAAVAAGYLALRGAKRRPERRAEGTHAPTGPTQPRGPQNTPPGACPRDREGQHGARCHARARRPSASPGRLPLRGPRPPAAPPTGSPSRGAVRMRGGRGQRARERMPVGPRGPADPAPQPRPYGHRGVGQTTRVRSGRGGPGEQHERRTARPEHRRGGRDLRHGRGDHVPRPSPQRPAEPPSAGTRREEAEVGRLGGRNRHHVCTGVARVDRGPPQGELPVAAGRRGLRQLPVLHANRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RGN5</accession>
    <name>A0A088RGN5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Small nuclear ribonucleoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_010160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009370">
        <property type="protein sequence ID" value="AIN95117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696659.1">
        <property type="nucleotide sequence ID" value="XM_010698357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RGN5"/>
    <dbReference type="GeneID" id="22571745"/>
    <dbReference type="KEGG" id="lpan:LPMP_010160"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000053900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_010160"/>
    <dbReference type="eggNOG" id="ENOG502SRK7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268799at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00600">
        <property type="entry name" value="Sm_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="80" mass="8682" checksum="3ED8D2855DC40F75" modified="2014-11-26" version="1">MSVSLESLLHQPVCCHLAHGEEYRGQLEALDGSFDVVLSRCTRSRASPRQPAEPLVFVRGENIIYIGFDESFGGEGGATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RGW1</accession>
    <name>A0A088RGW1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_010780</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009370">
        <property type="protein sequence ID" value="AIN95177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696719.1">
        <property type="nucleotide sequence ID" value="XM_010698417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RGW1"/>
    <dbReference type="GeneID" id="22571807"/>
    <dbReference type="KEGG" id="lpan:LPMP_010780"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_010012200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_010780"/>
    <dbReference type="eggNOG" id="ENOG502S574">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273792at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23672">
        <property type="entry name" value="MPSS5_OBF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001838933" description="C2H2-type domain-containing protein" evidence="3">
        <location>
            <begin position="28"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="187"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="189"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN95177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="410" mass="43450" checksum="BD188E64A23CA801" modified="2014-11-26" version="1">MPRAAPIALPAARWCLAFASSAPTASSLPLTSSAATPVESYQDNRPRLTPRALRLGIKAINSRRLGAAPHSLPSLCRRPSNLWVRCCSGNAGCRAVSSAPSSPASAGTAAKSTSAAHPTPPAPAPAVQERRVCPECGKRFLRESNLVHHRTTRHGVQVASASKVARAELAMRNAQLQQELARAQARVKQLREGSDSAARQERDSAATEPTDDATTRAYPSAVMTGRLMEVDEAVERAWRHSGRGLGTGVSFVVCIGTVLGPVEVGTLRGATPSSAADSSATGPRVLQFKLEVHGYRERRPGQLKMYRAHLLVRYVAWQPYHRYGDGDGAGSAAASSPSSTAPLPFKVQEGDLLRVQGHYALHTSHDMVSKQSVENVVLEADAVGLLRPAPAKEAPAGGGRGDGSPTRQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHJ2</accession>
    <name>A0A088RHJ2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Major vault protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LPMP_050060</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">The vault ribonucleoprotein particle is a huge (400 A x 670 A) cage structure of 12.9 MDa. It consists of a dimer of half-vaults, with each half-vault comprising 39 identical major vault protein (MVP) chains, PARP4 and one or more vault RNAs (vRNAs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="AIN95447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703769.1">
        <property type="nucleotide sequence ID" value="XM_010705467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHJ2"/>
    <dbReference type="GeneID" id="22572084"/>
    <dbReference type="KEGG" id="lpan:LPMP_050060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_050005600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_050060"/>
    <dbReference type="eggNOG" id="ENOG502QPP0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6125719at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08825">
        <property type="entry name" value="MVP_shoulder"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.620:FF:000002">
        <property type="entry name" value="Major vault protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.560:FF:000002">
        <property type="entry name" value="Major vault protein-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.570:FF:000002">
        <property type="entry name" value="Major vault protein-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.550:FF:000001">
        <property type="entry name" value="major vault protein-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.560:FF:000001">
        <property type="entry name" value="major vault protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.570:FF:000001">
        <property type="entry name" value="major vault protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000010">
        <property type="entry name" value="major vault protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.560">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.570">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.550">
        <property type="entry name" value="Major Vault Protein repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039059">
        <property type="entry name" value="MVP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041139">
        <property type="entry name" value="MVP_rep_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043023">
        <property type="entry name" value="MVP_rep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021870">
        <property type="entry name" value="MVP_shoulder"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041134">
        <property type="entry name" value="Vault_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043179">
        <property type="entry name" value="Vault_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040989">
        <property type="entry name" value="Vault_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041136">
        <property type="entry name" value="Vault_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002499">
        <property type="entry name" value="Vault_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14165">
        <property type="entry name" value="MAJOR VAULT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14165:SF3">
        <property type="entry name" value="MAJOR VAULT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11978">
        <property type="entry name" value="MVP_shoulder"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01505">
        <property type="entry name" value="Vault"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17794">
        <property type="entry name" value="Vault_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17795">
        <property type="entry name" value="Vault_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17796">
        <property type="entry name" value="Vault_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51224">
        <property type="entry name" value="MVP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 11" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Major vault protein repeat" evidence="15">
        <location>
            <begin position="49"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="MVP" evidence="11">
        <location>
            <begin position="54"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="13">
        <location>
            <begin position="115"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="repeat" description="MVP" evidence="11">
        <location>
            <begin position="119"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="13">
        <location>
            <begin position="167"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="MVP" evidence="11">
        <location>
            <begin position="171"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="13">
        <location>
            <begin position="222"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="repeat" description="MVP" evidence="11">
        <location>
            <begin position="224"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="13">
        <location>
            <begin position="326"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="repeat" description="MVP" evidence="11">
        <location>
            <begin position="329"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="17">
        <location>
            <begin position="378"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="16">
        <location>
            <begin position="449"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein shoulder" evidence="14">
        <location>
            <begin position="511"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="702"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF11978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF17795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF17796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AIN95447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="833" mass="93425" checksum="B3782D3A73C0C277" modified="2014-11-26" version="1">MTDSVIRIKRYYYIHILDNNTNVTRTISGPVVYTRQEHETCLFDPRPCVSVPPRHYCVVKNPCVRNEAGEVVLESSGQVKLRLGDAEIRFEGEPFPLYPGEELDSKEEQSVRKLQVIPPNTGLHVRCVRDFKDAERLVVAGTEWMVAGPQSYIPRVEVAVVEEVKATVIYSNTALLLQANVNFTDRRGVLRVAGEKWLVRTLGAYLPSVEETVVSLIQGTMLSELKALRLSAVRSFTDVYGKARRAGEQWQVTLKDAPVHIVDAYETKVAEVAAVSLNAKEYVIIHHPVDATGHNRFGETLVRRGECTFFLQPEETMPRGVEQVLVVGKEEALLLEAVCEYHDGGRKHQPGSRWMVRGPCEYIPANEVKLLEHRRVMALDRNEGIYVMNTTTGEVRAVIGRPYMLDSNEVLWEKHLPLAIEELLESPNGSIKTCERNAGFVSRREKYRIVRFNVQHNAAVQIYDYRTKKPRIVLGPRLVMLAPHEEFTVLSLSGGTPKVPNSMQSLQLFLGPRFSSDTIVVETSDHARLRLRLSYNWYFDIDRANPSQRTFSVPDFIGDCCKTIASRVRGAVAAEDFDSFHRNSAKIIRIAVFGVDEVGEAKKNLRFNANDFVVTNIDVQSAEPTDEKTRDSLQKSVQLAIEITTKSQEAAARHGNELKNQEAKGHLERQKLIDKIEVENARTKWLELQAKSEAVQASGQSIAEAKARAEALLIEVQSEMQQAEMRAKAYRISAEAELQKLQQRQALELEYTQRQNEIDVAKARAAAEAEAEKVRRMVDAIGRDTLVAIARAGPEAQVKLLGSLGLKGYLITDGNSPVNLFGAAHGMIGELKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHU2</accession>
    <name>A0A088RHU2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methyltransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_051010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="AIN95542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703864.1">
        <property type="nucleotide sequence ID" value="XM_010705562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHU2"/>
    <dbReference type="GeneID" id="22572179"/>
    <dbReference type="KEGG" id="lpan:LPMP_051010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000032900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_051010"/>
    <dbReference type="eggNOG" id="KOG2671">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="333024at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RlmKL-like_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370">
        <property type="entry name" value="RNA METHYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370:SF3">
        <property type="entry name" value="TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017259">
        <property type="entry name" value="tRNA_mtfrase_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00507">
        <property type="entry name" value="N12N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA large subunit methyltransferase K/L-like methyltransferase" evidence="4">
        <location>
            <begin position="240"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="534"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="603"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN95542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="622" mass="69222" checksum="30F81D964301826B" modified="2014-11-26" version="1">MSLCVRESARCGIEMMKKYVAVFASSASLTDFRLPEFQFVAATLHIPITLLNDKISWVSGGADTFWFSVFESPASRSELRALAERCALLRGIYTLFETTPTLEDLYACLEKRHGSAPGSVGPSLASSPTTDAAAFVGEDEMTHLTSSTYSYQVETIGKKYSADAKRAVVEAVLQRVPRAGEVEWRQPERAYYIFLQHAVENALPGAKGWISNGPLLRVFHCCLCVESSRSALLATYDLRKRPYIGTTSMPPEESLVMVNMSGVCRSHYVYDPFCGTGSLLIAAAHYGARTFGSDADGRAMRAGTEKGKTSPQIQQQRRLALAAYQEEQLCVLTEEERVWPSMITNFKVYHLPLPDRARMNFSSWPKTWHTCALRLGSGGIFDSIITDPPYGLREPRKKVETTASMEADRNNPTKQQVVTFSAYPINEVVLDLVLFAATHLVIGGHLTFWHPTTDHYTDDELPSHPSLRVVCNIAQRVSLKMVRRLIVLRKVAPVPTPPPSRESCAAKKSPDDLRVLMDATELPDNEDYMHYRAKRERKRQAAHEYKAAAESSSSSSSPNPTTSEHVDTDRGKGNRRGRKRGQLDGQDKIVANRQRNIELREAKQAASHLANAAHKTVDHSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RI30</accession>
    <name>A0A088RI30_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">S phase cyclin A-associated protein in the endoplasmic reticulum N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_041180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="AIN95440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703762.1">
        <property type="nucleotide sequence ID" value="XM_010705460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RI30"/>
    <dbReference type="GeneID" id="22572077"/>
    <dbReference type="KEGG" id="lpan:LPMP_041180"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040019200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_041180"/>
    <dbReference type="eggNOG" id="ENOG502QTN7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="71500at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31434">
        <property type="entry name" value="S PHASE CYCLIN A-ASSOCIATED PROTEIN IN THE ENDOPLASMIC RETICULUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31434:SF2">
        <property type="entry name" value="S PHASE CYCLIN A-ASSOCIATED PROTEIN IN THE ENDOPLASMIC RETICULUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="294"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="995"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="308"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1005"/>
            <end position="1015"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1061" mass="121339" checksum="FB3721738F9B71F4" modified="2014-11-26" version="1">MSESGRNDPPEDSVPTNVDNSDIEYHYLRTPKQGNFAGGNNSGLNTSDHNAISSFLLIGKLKSVVYEVLYNLENHGNLHDIDEFIAVTEDCLKALKTVKVERRIEARRMNLSMRIQVNSSMNALTTPSNRELDDALGDTVRTSAAMVSQGPQNYKAALLRQKLPSPKHSPARTDVQTRGDVEAARYASALRAEERQRQAEERRFDILQEIKQKSEVADARSLRAKARRVEAEARQRMETLDRMDNGVRRAEEARRQTREKAQRAHSRVEQVLLTKELLQQNKALLLDKKMSDVEHNQEQMRGKLQKQALERQEAVRAAAERRRNLSQERQEKQQQREQHRVDNLRRIDEQKKVDQEVKQQKAREWEKKVQQHHVDTTAEAEAQIRKTEEKFQQSAQLLEEQREKRQQKLERQEQKLREAKERRDKELEARVMLEEMMPRMSEQEAEQQASRMSRLSITTVHHGKVFVDTYQKMSTQSAKDLNRSRLRVVFSRLSSAVTAALLMQCKHPLSELTTLSLGDMDYEYVRYFNAFDTLAKVLVEARKARDFGTMRQTSDVLLSLFVHEKEGRENVVYFIKSGCTASLSTCLRDEARSLPLKHNTEALRCAMEVLGMCLEKISAEAQGAAKLIPVRDQLLNEMEVVGVDSVCVAVLQTCTEEEELYLAYTALCIIYTELSVITRRKGEVKRHWFQQITTSLFTLLQNMLTPNGSPLRECDVSLSGERVTILFCLFRTLNTLARWQLTKFQELLHDGSTDAGAAVDAAQERKGEIKRTVSADSLPALITRTELFHVLSGFFMFIHGHLEELETIPPSEDAAGTTGKNIRSSFEEALQFGVTLNGFPPFPCGNDCDPGDSHRLGGKHYHLRAALHECILLVGYLCFDDALLQDMMGWGRKKPLIGMMLNVLPIAYFSNARHILFPTILSAILQNNRNSMIVREEMSLAELLQFILQEYDPLTKRAKMYAQEHHKQLVAHKMETDPRFALMVKLQGKSWADMVDDDDLPPATPHSSETTSTTPAVEKEKLCKGLRATSLNPSNYFKLERRLPISYWPAAIEQLERLRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIE1</accession>
    <name>A0A088RIE1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_070410</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009376">
        <property type="protein sequence ID" value="AIN95727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704049.1">
        <property type="nucleotide sequence ID" value="XM_010705747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIE1"/>
    <dbReference type="GeneID" id="22572376"/>
    <dbReference type="KEGG" id="lpan:LPMP_070410"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_070009200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_070410"/>
    <dbReference type="eggNOG" id="ENOG502SBJM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6499288at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00121">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001293">
        <property type="entry name" value="Znf_TRAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF94">
        <property type="entry name" value="TNF RECEPTOR-ASSOCIATED FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50145">
        <property type="entry name" value="ZF_TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="296"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="TRAF-type" evidence="11">
        <location>
            <begin position="421"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="10">
        <location>
            <begin position="709"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="7">
        <location>
            <begin position="421"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="635"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN95727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="828" mass="86216" checksum="045ED29F3033DA15" modified="2014-11-26" version="1">MSSWTNAPASSCAAAAPNHLPGTSTSPSATCRRREAAVCPTSGAAPTFLGAVITFGASGCVATPLVAAPGTHCDDHTPTCTAARVAPAPPSGAPSAAAAAGQHDCVSHDFSGPLQRSSPTVLHLYATTTTAAGTANPKRRHGLLPPPIMSDVTRALGHRSCSCPNTRNAPAADAAIASSPVSTNSGVVTRSRAAVAATNSSSTLQVTGNQSSPNDMLTKETVPFPIYSFKPLGLWSALPTTGVTATAAVSASATTLELEASTATTNGVDVGTLLTHEMDSGVVIVDPCQTPDDLVCGVCMSVCRHPTATTCGHLFCRRCLQKWMQANPAAMCPLDRTPIQVELLHTDARAQRQINALPCHCPASLSRASQLELRQLGSAHRVLGDGTAEEGGDVGGTRGDECARQAHPRCTWAGCVSDAAAHMCQCPHIIIECPFAKHGCAVELPRSDMASHLKNCVADHLLLLSQALDASVEQCRALQGEVEVLRQRCPMRYPVALPNVPTGGPTGSSAPTISVSSSLLHGATTATSVPGMDVPTAVPTPALVISNGSSSGAATIAMAALPEEVSMSSVSLLRVAGSFGHGASTAVDYPSPVFSQSLRPYYHLHHRSSTAVEPTNLRRGTATEDMLLAATHRVPNGHDATTPMAMDTTPVRTPSPSRLGASPGSVPVANLAAAAATFVLPPGAATLLPTPVASAPSRAAPVVGGICGVDRFVWVITDVASLQAPCYSRPFSSHNVPWYVGMDTTATWAQCGVYLFADRHEHRVDFRVILYHNDPARDVVHVVRDWQEDYIGKGWGPLRFINRFTLEQDGFLVHGCLRVGIEVLSGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIJ3</accession>
    <name>A0A088RIJ3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cation-transporting ATPase, putative</fullName>
            <ecNumber evidence="13">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_071120</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="13"/>
    <dbReference type="EMBL" id="CP009376">
        <property type="protein sequence ID" value="AIN95797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704119.1">
        <property type="nucleotide sequence ID" value="XM_010705817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIJ3"/>
    <dbReference type="GeneID" id="22572447"/>
    <dbReference type="KEGG" id="lpan:LPMP_071120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_070016500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_071120"/>
    <dbReference type="eggNOG" id="KOG0209">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000098">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000187">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000378">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF7">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE HELIX TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1058"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1095"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1147"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1177"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1218"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="12">
        <location>
            <begin position="268"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIN95797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1243" mass="139261" checksum="395D33ADCE25DDEA" modified="2014-11-26" version="1">MPTECIVENTMIRQLRLLQRREWYTWVTIWPFAVLYVVSAVLYLYPELIWDRVTYLVHQTYIDFFHAICFPVVLFLHSFLSLFTIWSVKFRARLIYRTVAMERLTEATDVLVETHLHKGESEIVPLHQESDDGHPPCFVFQQRKWKLDEREGIFVKPRFPTKHSFSYYMRWEGLNKEADCAKQVDTYGLNKMEVVIPEFQDLFVDHALSPFFVFQIFCVLLWCLDEYWYYSLFTGVMMVGMECTTVYQRIRNMRTLRDMAEVPVRDIDVMRGGKRVTIQTDALLPLDIIVVPSNAPCPVDAVLVKGTAVANEASLTGESTPQLKEAPDDVEVSLSVKKHARHMLFSGTQILLSNGPHTSSEEGGHNRDKSQALAVVLRTGFETKQGKLLRTILHSQGRVSENSGEAFGFIGVLVVFALAASGYLLKHGLADPHRSRWKLFLSCVQIITSVVPPELPMELSLAVNTTLLALTKLQVFCTEPFRIPYAGKVDTCCFDKTGTLTTDEMLFGGVDMVDGKGLLNKLKAIPKHAEMVLATCHSLVYLDEQTLAGDEMEKAAITALGYRIDGEDSIFHDPKSAKEKGTEEQVTKKKGAAEPQRMYKVLLRFPFLATLRRMACVVSAPDGKYIVAKGSPESIAALCESVPANCLKIAEETAAKGYRVIALAYRPLTDAERASKDTIRALRRDDVEEGLRFAGLAVYVCPLKKDAKETIENLTGGSHRCVIITGDSVQTAISVGKDVSMLLCKRQLVAKEKETGGGVEWADSVSGVVQSGTAKDILTNTFQRSRRKRTPHEDEWDLCVNAEAISPESMQHIIEMYNERVTIWARCAPTQKEEIVTDLKKKGHIVMMAGDGTNDVGALKQAHAGIAVLNSASVAPKAEKEVEIGPQPHSEPDLPAELKVPPNFKFTAVPPEPPAGTPFMQMMRWKVLEAKRKVEITQVTRWNQQLKDAEKAKADKKASASLLRSGPGESDFLMESLFNADDENMGGPPMIKLGDASIAAPFTCRSKALTSVCDIIRLGRTTLVTTHMMYKILALNCLTQAYSMSVLHCAGVKFGEKQMILAGIILSVCFLFMSRSKPLAHLCPQRPVTKVFHPYMICTVFFQFVLHLYCMMKTSWMVAEVDAATMSDMSKNYQDVEFKPTLLNSTMFLLTTLISGVTFAVNYRGEPFMQGIRKNRPMFIALIILSIVVLCFAFESSPEFNKEFEITAFPTEAFRTRFTQLLMLDALGCFVIEKASLMLFTDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIU9</accession>
    <name>A0A088RIU9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_070190</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP009376">
        <property type="protein sequence ID" value="AIN95705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704027.1">
        <property type="nucleotide sequence ID" value="XM_010705725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIU9"/>
    <dbReference type="GeneID" id="22572354"/>
    <dbReference type="KEGG" id="lpan:LPMP_070190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_070006800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_070190"/>
    <dbReference type="eggNOG" id="KOG0589">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="6"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="264"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="455"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="511"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="556"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="634"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="731"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="783"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="276"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="740"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN95705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="835" mass="90571" checksum="8037CBD7CB570780" modified="2014-11-26" version="1">MGMEHYTKVKDLGGTNGAFLARDRQQPDRLVVIKRLAEGTQGVEELNASLRLRHPHIVRFLESFFYDGSLFVVMSYESGGDLDGLFHYLTQHHKTPTTHTLLLWFVQLLEALVYCHDHSVIHRDIKPGNILVSTDTKVLYLGDFGSAKTLSISNVTSTFVGSPMWISPEVLLGTSYSYAADVWSMGCVFYEMATLRKPFSAPSFAHLVQQITWGHITPLPPHVAQEVRSIIHSMLVLDPAQRVTAREALEVARVALNRAEELRCASPSPVRSPARLPKPPVASSPPLPVSPPKVADYQPRQHPLPQSPQSYSSPSSPPSTGTTPPPASATSDPLLVVAAEAKAGEDPTPQGSHPTAIAAAPESLSHVAGVKQLPDVSSPALTAPESTTSFTSLPSMVEFPVPKQPPAVLTVAAEAAVGDKPERHQAVPAEAAQLCMPQQVALQISTEGFFRKEVQTKEAPKRKSVAASKASPLPQRQRVPSVPAQTALSTEAPRFVRQISTDSMAIRCTTSATAASRTRAAELPTPSRRTGGSTKVVVKAVPPTHVPKRALDAAENLTNPPCVPRESPTRGARGLNEAQQKSAPMPPPKPAAQASDAAPADQWFVLRMRDLRAMEKYLHHHRVDDDKALKTYDQRRDKEGQPCDSAPAVRAADKPLAAPHRRTFAKKPANAPQSPGVLILTPPRHRCLMEGIPAPPLLSAARQQQHGAAKVEARHGAAAVPFSRQVSYARQASHPACDSDLQQSSLPSAYNGRQASHARGRPRVSLEEQLKSAEGRVVARVKREEERQRMKELIKAQRAAAKKQNRKAKRDGAIDVQIVLPDHVRHTTNCVVSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJ78</accession>
    <name>A0A088RJ78_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Signal peptidase complex catalytic subunit SEC11</fullName>
            <ecNumber evidence="4">3.4.21.89</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Signal peptidase complex catalytic subunit sec11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_080460</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S26B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="4"/>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="AIN95855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704177.1">
        <property type="nucleotide sequence ID" value="XM_010705875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJ78"/>
    <dbReference type="GeneID" id="22572508"/>
    <dbReference type="KEGG" id="lpan:LPMP_080460"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_080009600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_080460"/>
    <dbReference type="eggNOG" id="KOG3342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10257561at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009003">
        <property type="term" value="F:signal peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806:SF6">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00728">
        <property type="entry name" value="SIGNALPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIN95855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="216" mass="24814" checksum="9643A5BC17CCA40F" modified="2014-11-26" version="1">MRVCVLHTSPGLSFLSSPSPHPSDRHPSHRHTHTHAMREHIDTLLSLRPRDVIQQVINIGILLSIIFFGWRSVAIATNCEASIVVVLSGSMEPGYQRGDVLLLHHRPEYPVEVGDIIVYTLPEHEIPIVHRVLRIHERAEDHKKFYLTKGDNNVNDDRFLFSRGREWVEEDMILGKTYAYMPRLGYITIMFNESKLIKYLALAVIGFLMLTSPEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RK61</accession>
    <name>A0A088RK61_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_101010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696823.1">
        <property type="nucleotide sequence ID" value="XM_010698521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RK61"/>
    <dbReference type="GeneID" id="22572838"/>
    <dbReference type="KEGG" id="lpan:LPMP_101010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100017000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_101010"/>
    <dbReference type="eggNOG" id="ENOG502S7IF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="248563at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="428" mass="48189" checksum="228F22D44A3741E9" modified="2014-11-26" version="1">MPAKSQFLKGLEDKPHHVTIPLEDWHDLTFRKCLSFTRLYGVSGMRIYAQTKSGNMENRTFRIIHVVPRFMSEAELLDREKLPLIAKERNLEYARVCDALYRLQRRHAQTHSKAVSPVPPAQTLDIGGALAEVLALRTTPCFGLHLLVTVQSENTEQQSASPALTDVAARAHLKRLPLPVLHRFISELAAVRAAWERDLLAPSAAAAIQEQALLGREVINAFLYHICLWQRRYPLELLSAVLSFYDDQRQPFSPATPASRLTPAHLESLLEEAHRLYYPDLSDVPGLIRCDVFMTYPHMPLEEQRQLMRKIAAAVAHREAAGSLRHQSTSMGAEEDCATDNLFGHSRTPPDPQLLLRSFVVDGATVIPERFCTDMSTEKYHTMRDAFELHKHDGVRRLAAQDYGRTSTNLTSLPPPQPAASSMGCRHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKD2</accession>
    <name>A0A088RKD2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_110800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696928.1">
        <property type="nucleotide sequence ID" value="XM_010698626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKD2"/>
    <dbReference type="GeneID" id="22572945"/>
    <dbReference type="KEGG" id="lpan:LPMP_110800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_110011400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_110800"/>
    <dbReference type="eggNOG" id="ENOG502RXT1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270622at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN96275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="257" mass="29659" checksum="F82C68E88C764FE2" modified="2014-11-26" version="1">MSGVNAWGRMHTPAKQSQLTLDMFEEWKAKQNEDISQRGADRDPAVEEEHNRHMLRQNLNAYVCYKELDKYTTCLEDKKLIRRRSGEDNARGGGTGVSSIASSVEINTQNKANEKLCRATHNAYVSCMSSQSNQQLVLESASLEPHCTERRATLFHCLHENQVSEAQTSTPQCTDAYRRLLRCGLNHLWNHYWRELTKFSDTDEFHLYELSRDDNKKQAYLRAITTSEAEQQSHLREARDIALGYYLDPKDAQRSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKR8</accession>
    <name>A0A088RKR8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_070580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009376">
        <property type="protein sequence ID" value="AIN95744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704066.1">
        <property type="nucleotide sequence ID" value="XM_010705764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKR8"/>
    <dbReference type="GeneID" id="22572393"/>
    <dbReference type="KEGG" id="lpan:LPMP_070580"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_070011000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_070580"/>
    <dbReference type="eggNOG" id="ENOG502S5GI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="243206at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="821" mass="87958" checksum="20B45FADA36F886F" modified="2014-11-26" version="1">MPSPLGWRHSSAPSPLVPLRGSSLSSLLWGWGDSSGEGTHCGIATTVAGAVPAASPSPYEPPRQRDKHAWEEDSAQCSSVNGINASHPVSPAAPAVYAPPTAHAPHCDAAYEEVKEEQSSQSWRQPLRRPPLAPSSTGATSTTAPQSASADRVVHPVESVELVSHLNANEHAANVCRIAYYLKDYYAREAGEAERGIESLSAEDVAGLAQCFYIDLYRTVRQARREAGMETSSFLVEDPAENVIARVAPAPPPPPQRERRDGYTQHQGAAALCHSSSYLPRRSSAAPGSREREEVDDRELDDVEAQIPPVTTPTPPAPATTYASRGPPDNAVLPSQPCVSARVQHQQQCTTASDAERRLANSNTTSCTGTTYRAPNDQLAFSGGGTHPVQIITARLPAFRNDDAITTGVGPSVQGHHKLSVTSSLLPAAAGTTPASRARKETHARGSPANQTAVACDALSYNLDDANAKAVPSWAQAAKPSPLHRHLRSTADTARAVRSRVTEPNRQSPSFEPRMVLGASQHHPSSAPSRFAAMPAGSSSSSWLNHHQGDTRNSRQHHRNGRQDASLQTHGRHVHVRDRRVGRSNSGEGSDDDGETGECDGRRGPSGGADRAALAAAQELPSGIVKRPLKDLMPLLRSRGTLAVKYIHNTRRPHLRLFQILDCKDMYRGSEVLMPHFTWATPIGVHQHDRLPRAKRSKYGALLPTGLSLSQQEVPYETALNLIHLEAVYVGAGRGISEMYMTLFPHTKGGISSSGDGSSFCDGGGGAVVVDHEGRRVACGMCAVFVFASRPVAVSFLCEGDRQAWVGAMMAVVERNRSLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKV0</accession>
    <name>A0A088RKV0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_131310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697211.1">
        <property type="nucleotide sequence ID" value="XM_010698909.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22573241"/>
    <dbReference type="KEGG" id="lpan:LPMP_131310"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130017800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_131310"/>
    <dbReference type="eggNOG" id="ENOG502RX8Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273507at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="630"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="772"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1038"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1333"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1062"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1340"/>
            <end position="1353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1674" mass="179475" checksum="A3764F42A9E9F5D4" modified="2014-11-26" version="1">MHSHRHISGLTCRVIRIQASRVHRYPSYRGFTPLGPLLTHLLRKTHTERERERSGRKANKEKARIGSSVVVCHTRRHARMTSSLSPSTLRLSHTAATVVTEAADVSLDEYFEACQASSSSGSSSPRSSSPPTSKSVSCPFKASPYGAAVSERNTATVKSHHHSYGLRSDDPAAAVAAGLPTPLQGNVTRPLMLRPRPLHSPLFPDTLISIPSTVDEGGVLPQGASPSHTSTHSPHPSWKPEPVAQPRGSTATLSRKGAVVRGVAGHVLAKRLKNTTLPCAPPSYSFSSLSSAVNHSGAVAPEWVSSAFMFQLPPPTDTAAAAQGKKRLSTTIMTRGGPGGRPSSSSPRTAHRAVAAAQEDCLARQRAVLFDVLCALRQHPTASCEMCADKGSSRDGEHAGPSPASYRGQWRMREAVLTEAAAKAWSPTFLGVLGQLLEVANVVAAVDNHVRECEPVLGHHAAGDLAEAHGIFTSNVTAECKGIQDASVALEIAAVRSLKRLCSVLRQLSTDFCRWVLQVQEYLLVVCEGAIAVSHLNGPQPSPLLAGSVRPGLYKRDEETPHAGGGRQYPLGTGSYTAASSGVPLTVLPVSCSLADLVTAVRENIAPLQRCHVLVVKSGCFEGLASFNRPSDTSRPASTTRGAEAHPAGGQAPPRSSSCALLAARLLDTLIIQASAFQDTSTMDLYRLYVMMLLYTSWPYVLLCTAAIFGFVRGIDPPVWRRQLPRLFRSSFSHVRIGDASRRCPTDILSLLLNCVGYYNADDVAASVGAGENGTGVAQPAREPLPLSAGRSRDPVVTSWVSAPRQAGAGRRSRCVGEASGQHVARVALASARTFVLRSLASFTRRHRQVALSRTPMPSRRISAALTSVKGHTATTATAMSATSSTPAGTTSCQLWHTKSVKEILHYIMYEAGDRQGDNPGDGDQAGSGAVSAIVAYAQQNQDVHRRVVQVAAPSTAVAAVNATGSSNASGSTGALHYAYFPTTIPLGFVTMLAEGLTGQQQWQQRRGDGGVSNFTEEQGCLASSSPAFYPGQRRVAGGGVGCGRPHSRIRSGDTNATATFEDNDDDDGGDSGDEGSGVLRRRGISLWTLSISELATIPDVRFTNILAEEEAKFLDAVDDGGTKFSQRSLAQRKRRSHQLWINVTIPCARWVTTALLIPIGVAVQRLQERRLQALFTRSLHTAVGGGDRGGGCFYPRSLHEPAHEAQQQQQQPVDTTTPAERLPLGPLAAFNGLARNGLVGRSNTAACSFIHATKLLVDVALCRDQERLVHGFLEQLHQVPRWWVRQGEDGGVGAYGRLGTAAPVISAVFADALRGKRFSELVRLSVLPARVGGGAAAPSMTTADTPTASGLQGRQGEEGHSSPSVVEDMLDVFASFQLSFAFPDAFECMLQPRDLSMYVEPLTGTTERSYQTYFWQRRRRLYVEEGGAGERRASPVPSVVAGSTGIALADVWSYAFGYQCALYYAHITLQAHQKQLHERDTQDAQIAQSMGPPGQSAMQHLQCVSRGMGSAYYTLNFAVGQLLSFTQNVSMRVVYDLERLLAKAMSSSPVLLSCMELCYQLDALLLELYVVSFPARPPVALNVRERGMQSPAAEAVRAAVQRTLEVALDPSRLPASHIRNCTRNAVEALVATVSAAAEHHPSALATHLQPLVVRLTFNRYYGTDEETLSFHFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKZ1</accession>
    <name>A0A088RKZ1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="12">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_140660</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="12"/>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697300.1">
        <property type="nucleotide sequence ID" value="XM_010698998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKZ1"/>
    <dbReference type="GeneID" id="22573333"/>
    <dbReference type="KEGG" id="lpan:LPMP_140660"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140011800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_140660"/>
    <dbReference type="eggNOG" id="KOG3072">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF105">
        <property type="entry name" value="ELONGATION OF FATTY ACIDS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIN96647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="284" mass="32325" checksum="D64EB5C84A36F2A7" modified="2014-11-26" version="1">MEALDNYLITHFDGHAVQNWLANNVDIGVYIAAAYLTFVFKGPQLVDFIFSGNPPTKLIKMCWSLWNVGLAVFSMYGVYHTVPLFINNLRRYGQKDTLCRFREEEFFTGKHGVAMGLFSLSKLPEFGDTFFLIMGGKRKLPFLSWFHHVTIFLYAWMAYQQASSIWIVLASINYFVHSIMYTYFALAEAGFKSLVKPFAMYITLLQITQMVVGLYFTVSFIVHHKADPQGCNGSTMALARGQCMIYIFNFYLFSEMFVKGYVLPRKAPAGEATAVTAPASKKHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RL82</accession>
    <name>A0A088RL82_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">IMS import disulfide relay-system CHCH-CHCH-like Cx9C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_090380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN95954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704276.1">
        <property type="nucleotide sequence ID" value="XM_010705974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RL82"/>
    <dbReference type="GeneID" id="22572608"/>
    <dbReference type="KEGG" id="lpan:LPMP_090380"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090008800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_090380"/>
    <dbReference type="eggNOG" id="ENOG502SRJ7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3821113at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN95954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="87" mass="9535" checksum="15A4D3F045639819" modified="2014-11-26" version="1">MEGNFYVSDIVIDRELNSKYGMAYTKCPNESKRYGQCIEAGQINRDLQRDSCAKERQALRACVLKHLRNSAAGSTASSAASDGAQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLC0</accession>
    <name>A0A088RLC0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNaJ chaperone family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_151150</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697490.1">
        <property type="nucleotide sequence ID" value="XM_010699188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLC0"/>
    <dbReference type="GeneID" id="22573535"/>
    <dbReference type="KEGG" id="lpan:LPMP_151150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150016800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_151150"/>
    <dbReference type="eggNOG" id="KOG0712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000074">
        <property type="entry name" value="Heat shock protein DNAJ, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="8">
        <location>
            <begin position="143"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="5">
        <location>
            <begin position="143"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN96837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="470" mass="50406" checksum="27DCB3384EBDD854" modified="2014-11-26" version="1">MVKETGLYDELGISPDATEQQIRSAYRSKALQYHPDKNNGDLAAAEKFKKVSEAYEILSDADRRKQYDTFGRNGPGGAAGGSGGFPGGFGHGFGPGMDPMDIFSSFFGFAAGGGPGKSQQQRPAKPSFILVELQCSLEELYCGTTKVLLVRRRRRCPTCQGHGTSNGQPSPVCPQCKGNKTVMKGLSFGGLMTYQQCRCDRCQGLGKLPIQFPCARCGPIYDAHQRAQLSGTLPRGVVEEEKKIKVTIAPGAEDSDALNYPGQGDELPGFDAAGDILVVVVQLPHPHYHRLNSTDLLLSNCRLPLWSLFRDAFSIPVELLDGRVVRLAPPLREDNVPHFLFDSHHVFVVENEGMPLKAQTNGGAAADESGDGSGSAAGAAHLKKGKLYVCINVVFPHSLTPAQMDAITKVLGGSGECDRDATAGDADSVVTLQPHHGPAPSWHRVDAEGNAWYKPRTAAAAKRKKPTRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLH7</accession>
    <name>A0A088RLH7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ecotin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ISP3-2</name>
        <name evidence="3" type="ORF">LPMP_150510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I11 (ecotin) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697426.1">
        <property type="nucleotide sequence ID" value="XM_010699124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLH7"/>
    <dbReference type="GeneID" id="22573471"/>
    <dbReference type="KEGG" id="lpan:LPMP_150510"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150010300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_150510"/>
    <dbReference type="eggNOG" id="ENOG502SM48">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="16445at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.550">
        <property type="entry name" value="Ecotin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1230.10">
        <property type="entry name" value="Ecotin, trypsin inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027438">
        <property type="entry name" value="Ecotin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036198">
        <property type="entry name" value="Ecotin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005658">
        <property type="entry name" value="Prot_inh_ecotin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35890:SF3">
        <property type="entry name" value="ECOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03974">
        <property type="entry name" value="Ecotin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49772">
        <property type="entry name" value="Ecotin, trypsin inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="266"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="309" mass="34590" checksum="C4AF0475D5D49081" modified="2014-11-26" version="1">MPSLEDYRIPYPAAGPRQKRTVIYLPQQDSAVEQHHLRVQLIPGRHVRCEDGCFYQLTGTVSEETLQSWGYPYYVVTLDDIYPAQCSPSDPANPMTFVPLRESLMIPYNSKRPIVLYVPEDAEVRYRVWCSDVLQVQESQQELEAPAVSQSCPVPVRERQNNPEDHAHPVVVHSVESPEVSGHKDSDQPMKKSSKLKQSCSNSSRSLKHSASGSSPKNTPLFSRESVPPEHSLSAAQQRRRSNENSAIDETGGGASMKKRSGSTSSRKDDQDSGYEKKVKNLWNRARGNSSPKRSASPKKSGRDSRRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RM03</accession>
    <name>A0A088RM03_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytoplasmic translation machinery associated protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_110180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696867.1">
        <property type="nucleotide sequence ID" value="XM_010698565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RM03"/>
    <dbReference type="GeneID" id="22572883"/>
    <dbReference type="KEGG" id="lpan:LPMP_110180"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190006300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_110180"/>
    <dbReference type="eggNOG" id="KOG2523">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10249667at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11609">
        <property type="entry name" value="MCT1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21155">
        <property type="entry name" value="PUA_MCTS-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016437">
        <property type="entry name" value="MCT-1/Tma20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041366">
        <property type="entry name" value="Pre-PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048248">
        <property type="entry name" value="PUA_eIF2d-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798:SF0">
        <property type="entry name" value="MALIGNANT T-CELL-AMPLIFIED SEQUENCE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798">
        <property type="entry name" value="MCT-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17832">
        <property type="entry name" value="Pre-PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26292">
        <property type="entry name" value="PUA_elF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005067">
        <property type="entry name" value="Tma_RNA-bind_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-PUA" evidence="3">
        <location>
            <begin position="9"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Eukaryotic translation initiation factor 2D-like PUA RNA-binding" evidence="4">
        <location>
            <begin position="112"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR005067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN96214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="196" mass="21618" checksum="9F9C8FA3DCBDA0EB" modified="2014-11-26" version="1">MATSADLFKKFTLENVAQIASSSHKEQKEVREELAEQYPALREHWEEILPKKSDIFIIRCQGQVHCITLVSSQPEVLFFNHHGGPYMPHLKLLHKYPFMLKGHQMDIGGCRHVISGANVMCQGLTSAGGVVADDTEEGEVVAVYVEGKAHAVAVGVMLISSEEIKGRNRGPCIENVHHLGDGLWMNPILSASHISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RM45</accession>
    <name>A0A088RM45_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome c, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_161280</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="10">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome c family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN97003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697656.1">
        <property type="nucleotide sequence ID" value="XM_010699354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RM45"/>
    <dbReference type="GeneID" id="22573707"/>
    <dbReference type="KEGG" id="lpan:LPMP_161280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160018100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_161280"/>
    <dbReference type="eggNOG" id="KOG3453">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="449280at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000014">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002327">
        <property type="entry name" value="Cyt_c_1A/1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11961">
        <property type="entry name" value="CYTOCHROME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00604">
        <property type="entry name" value="CYTCHRMECIAB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4 8 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 8 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="11">
        <location>
            <begin position="12"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN97003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="113" mass="12134" checksum="4630160C84B23A36" modified="2014-11-26" version="1">MPPKDRAPLPPGDAVRGEKLFKGRAAQCHTATKGGSNGVGPNLFGIVNRKSGTIEGFAYSKANADSGVIWTPEVLDVYLENPKKFMPGTKMSFAGIKKPQERADVIAYLETLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMK9</accession>
    <name>A0A088RMK9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_180910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697925.1">
        <property type="nucleotide sequence ID" value="XM_010699623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMK9"/>
    <dbReference type="GeneID" id="22573981"/>
    <dbReference type="KEGG" id="lpan:LPMP_180910"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180012000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_180910"/>
    <dbReference type="eggNOG" id="ENOG502RSGF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47930:SF2">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_8G04250)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47930">
        <property type="entry name" value="YALI0C12947P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="655"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="993"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1058"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1064"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1094"/>
            <end position="1114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1136" mass="121865" checksum="8B47EB80FDB0FDD7" modified="2014-11-26" version="1">MGWMKKPPQQEKGVAIHMLAGTPWVAAAAALPYFLTQPLRCSHQLWIEAALRGQSSSRHCALLHQRCPLSSKASVMPRSFASTHTQRGWNPTERETGTAQASASATRAAPASAKTTHHNEDSSQDAAARLNAATPPPSSSSEAAHPYSVRAYRAQLMHGTYSSLRELTRAAYAPAPLKVLTDLLQLSVNLSCHDTELSLRSSFSASSPATPTPLAQSGARNALSRARDVQHVLQLALAEAHDIVLAAQTLGDIASHAALEHLLAQLETLVNATDACVHAPAPATPARSSVTVPAPLPSAPPAWIMPVATHAALLHGLLRLATATGSRLQALTTLDDLLSLQERQLHSVSALHGSGQLYRGDGDEDDDSFSMDDAVALVDAAAQQYVEPVTAQDHLCAMQACAKDHNRDFATALSLYRRFVQHAEVGRFAVTPNDFTHALITLAHSSRTTTDFTELRALLRESEAAAVVPVSVSLYTAIIGAASRAVEEPQRMAIALSIYRRLRDVGLTPTPDTYAALIACCASTREPTHAFAFYHEARQVCGVGRFTPQVYTNLLLSYTAAGYGADARKTLDVLVEAGAPLSRASFHAVLAGAVTVREAQEVIELMTERYHIAPTPHTYAYVAQAVARSPKGASTALQLTDLHEDAMRSLAQMTDTTMRSPGGDDGGEAQIAGGKAMSTSADGVALEPILLERYPLYVRAMEQALMRLRVDLSMDSRLRPYLMPLIRIAQQRMNAFTGMPPQSPTHVPEKERLCIAVLAADVLANVDEWVVPFISHYSVLVIPYSALVSLQRGGGRRIDGAMPKGSQAGRHDVVWQETTGGQESDAVVEHRRRRLARFLKQYKDVIHLVSLEEELRWSRETRRYGVGVTDLFARAAVTALHLARHDSPSSSGSVYAQHPNVSVVLVSATYNGCGKYVVALKQAYAGRTKSSATAGRTAESAPGLRAALSRVSYHNPRTNPSWAPPTLAIASPEKDAKHEGDDKRHAPVTFTVPASETHVRGGARTTEDNTASDATASVDRALDVDGKGLGSAWHASALDADAAWQLYWKSLQQASTPEHRGALNDSSVRNLSSSDGGKSSIAMEERKVTLQLPPSQPSPTAPTSPTLPPLPPPTSSTSANTDGNLDALLLMSLFND</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMP1</accession>
    <name>A0A088RMP1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L34, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_181360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL34 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697970.1">
        <property type="nucleotide sequence ID" value="XM_010699668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMP1"/>
    <dbReference type="GeneID" id="22574026"/>
    <dbReference type="KEGG" id="lpan:LPMP_181360"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180016600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_181360"/>
    <dbReference type="eggNOG" id="KOG1790">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277449at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.370.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008195">
        <property type="entry name" value="Ribosomal_eL34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038562">
        <property type="entry name" value="Ribosomal_eL34_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10759">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01199">
        <property type="entry name" value="Ribosomal_L34e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01250">
        <property type="entry name" value="RIBOSOMALL34"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="111"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN97317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="169" mass="19358" checksum="E4B917CA962A7F08" modified="2014-11-26" version="1">MSCPRVQYRRRMHYATRGNRMKMVRTPGNKLVMQKRAKHSQGIHTPWVLGHKRLGGTKALRHIDARLASRHEKSVSRAYGGVLSHAQVRDRIVRAFLVEEQRIVKQALKEHKKMKLSHRRALNKKKSKQSKKEAIAKKISTKRVAKKKAPAAKKAAPTRQPVGSKLVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPI3</accession>
    <name>A0A088RPI3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_202160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698417.1">
        <property type="nucleotide sequence ID" value="XM_010700115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPI3"/>
    <dbReference type="GeneID" id="22574425"/>
    <dbReference type="KEGG" id="lpan:LPMP_202160"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200027100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_202160"/>
    <dbReference type="eggNOG" id="ENOG502SFVT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272020at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39668:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39668">
        <property type="entry name" value="HYPOTHETICAL TRANSMEMBRANE PROTEIN L6586.03-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="138" mass="14825" checksum="2F34132569335744" modified="2014-11-26" version="1">MGFGTRSCMVFCYLNAVCAIFISYLFSIGISSMAIASVINKWDRQEKARACRNAGILYFIVAVAMTVKDMIDTCRERHMSRGVGQRMAEYGVADGPAGTAEAIALLERRAYVQRGGARRSDAARGGGSSSGGYGSVPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPQ2</accession>
    <name>A0A088RPQ2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Enkurin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_204500</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698650.1">
        <property type="nucleotide sequence ID" value="XM_010700348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPQ2"/>
    <dbReference type="GeneID" id="22574661"/>
    <dbReference type="KEGG" id="lpan:LPMP_204500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200051700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_204500"/>
    <dbReference type="eggNOG" id="ENOG502RZ07">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2123594at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027012">
        <property type="entry name" value="Enkurin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052102">
        <property type="entry name" value="Enkurin_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21490:SF0">
        <property type="entry name" value="ENKURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21490">
        <property type="entry name" value="ENKURIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13864">
        <property type="entry name" value="Enkurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51665">
        <property type="entry name" value="ENKURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enkurin" evidence="8">
        <location>
            <begin position="229"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="99"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="228"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN97943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="354" mass="39601" checksum="85A1E76C0D3DFF00" modified="2014-11-26" version="1">MSGESIFGLYVKSAVEQKQLSKNESPYTGVYEKHMAEPEKPAYSTFFEKGKQYDGTNVRFFKQREAIIGKNVGDTVDPRQYLKKGNGVRYIAPVTHEEKMYRKPPVDNNSIQLNQGGQSGDAEKSSTNMQHGADNNPVSSKDGRFDAGCSGENGNGAHGSASDSSLYGYGSGDYGAGYRGGDAFSRDATKDFVASNIVEVSNMVPKRQKMQAPLPTSRKSFGEAPAYLSRVKSEIAQEKAYVQSLEEAKAQRKQQVHAKYIYLLPREEHEKLVQQMRRRNDECISELQKIPFSKDTPGTRKRKMELEKTIADIEAALKKLDKDALFIYKDDPVNGQWSKEIALKEAQRYSAHSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQ16</accession>
    <name>A0A088RQ16_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cell division cycle protein-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_205720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN98063.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698770.1">
        <property type="nucleotide sequence ID" value="XM_010700468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQ16"/>
    <dbReference type="GeneID" id="22574784"/>
    <dbReference type="KEGG" id="lpan:LPMP_205720"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200064500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_205720"/>
    <dbReference type="eggNOG" id="KOG0735">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272635at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051228">
        <property type="term" value="P:mitotic spindle disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001602">
        <property type="entry name" value="Cell division cycle protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF197">
        <property type="entry name" value="DIVISION CYCLE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98063.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="823" mass="88943" checksum="ED79C0E681B73DCF" modified="2026-01-28" version="2">MAGFTDALVLEAPVLWWPAMGELPRYPIDHQRSFVAAIVEEAMPWTQDTDTSKGAAIRTLGLSRLGRSVMITAEWGCLDDINADRFPFVKVWNPLQGCPVYLPVSVEAGLGLLASVHRGGENGSGTAFLTALDLRQLTLDERVRLTHRSLREILSQHCCSRTAFLTRMQRCAQQKEEYVLLHRALKQAHATALKYLNRAAQAMDGILAGDCGSPKQAGISSTSLSSLLFTGDTPSQQHLLRLLQTTTPSVVQVSSTQVFVLEARSLNLAETLTLPELEALEVVEAVLRPPPLCASATTFSRTAPPSSLSTVHISPCLLVVMKSLHLLEANANSLVASVTHQLCVCLDALHAGPVPALIWSFTEDVRDIPPALLARVGAQYERLATTTAEDRTAYLTRRVTRLPLALSLPQAVCHTAAVSVAESTAHWTVDQLVRLRDADLVLMLPSIPVPTEKVSDGASGLSMRPHEQQKRGVEVQEVQGGVPATSTTAMVARRPEPPPFDVYSRLYGIEEAICTVEELIVWPLTHLLLLRELAIPCATGVLLCGPSGSGKTALLSCLRRRLQLPDARHIHVMSVDGLSLIQKEVGHSEKNIAQLFSTARSLAPAALFIDNLDSLAPPRGRTTAETNTTADRTLSTLLTQMDGVGGGQADRIVVVVASAPSIATLDPAVCRPGRLDVHVQLTSPPTSASAAFMKRRLREFVSHMLRRRQSDGSRVIENEARVAMLEVLEEVDQLVDEYVASVTANVGSSAEGDAALPPRSSLSPAEVTAAIREVMLTTIARMKRDDDPTQHSVTPSSNTQVVDRSSDVARAVRDAVRHLYAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQE9</accession>
    <name>A0A088RQE9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Exonuclease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_210880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPG/RAD2 endonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698875.1">
        <property type="nucleotide sequence ID" value="XM_010700573.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22574910"/>
    <dbReference type="KEGG" id="lpan:LPMP_210880"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000050300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_210880"/>
    <dbReference type="eggNOG" id="ENOG502R9RQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="17262at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022039">
        <property type="entry name" value="MKT1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022040">
        <property type="entry name" value="MKT1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF28">
        <property type="entry name" value="POST-TRANSCRIPTIONAL REGULATOR MKT1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12246">
        <property type="entry name" value="MKT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12247">
        <property type="entry name" value="MKT1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Post-transcriptional regulator MKT1 N-terminal" evidence="5">
        <location>
            <begin position="879"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="domain" description="Post-transcriptional regulator MKT1 C-terminal" evidence="4">
        <location>
            <begin position="1121"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="298"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="443"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1080"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="302"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="318"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="385"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1081"/>
            <end position="1093"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN98168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1372" mass="149972" checksum="D9B4DC9A38E22C1A" modified="2014-11-26" version="1">MPPRMHRGGGGQGPAPQQQQQQPPPPQQQQQQSPTQPQQQQQQQQQQGYGNGTGGPPSHLHVFHHHTSYNDGGRGGMPPPPHSGSSGSNNMNNMVYGGGSGGGNVPTSPVYSGGGTTYGGSKGSIPPHMMSPSPHPQIVGMGSEYAPRMQTSPYPQQLPPPPQGGGPNTPNSIGRRVRTPGPSNMGPPPQQQQQLPPPPPQQPYYGGNQGGGMGYNPNMRGSAPPPPPPHMEPSPSFVNSAPQQPQQGMMRGDSGYGPDMDSSSPPQNNGYRAGQPPPPPLQHPQQMHMQLPLLQQHYQANGGYGGGGGGRGMGGGVQNPNMQMQPLPQQQQQQHMMGGGSNAPNSSSRGMMGAMGGNKQMQPGPLPPLQQQSQPGMNSNWGSPLQPPTHMPPNLSPPPQGQPQIGGMQYVGGGPVPMVGRGRVPGARMGVGSMGSIGNSMGAPPPALPQQQRQPPSVMGGLGGPQQMPGSGNMNPQMMMPPTPQGVQGPMMQQSGGVPGMYAGGMDANMMGAMGGPPMAGYMDADPRGDLAPQQTLYEFLMEKRLLRKTTLSTFFPEDYDAKRDSRITIAVDGNYMITNLRAQLQRTDPLWFLHSCLPDCLLSLVHKHVEQMRAHHLEPLWVLNGISINGDVEAFLPSPDELHSRDAVWAKLNEGLELPTQDEITEAFETSSAVGEDVLRAIQRFLRTEENVVCVTAPFLNWCQMCTLHKEGIAQLLMGPPEMLMVPYDDMKAIAEVNLQTSEVAYYDRDEVLRELFPRYVTDTSTAAAGDRFLDFGLLIASHPAITTAHASVQLSTQSIYEELSTPHPNFNTLREFIDQYEYPQNQNERPNLEKLKHSKGRTYIQYSPVFSNQVTSESSLVYFKRILDPSLTNANMPNNLSGVFGYLVPLSLFYFQFTGLLSVGLMTAVTQLYIRDEFPVADTEEYHHLLHPLMALRGQIISQMVSRIKADAHGQRLGKISWVRWFDSILMSVLPPDRLIVLDEWNLKNSPELASVPDDQLENIDMSMVLSLKSSVMCIPAPQTPPNASPRDAPILYHGKKETFFAILLKTFDFVGYFSHSADPMDGAELVSEPVQAMVQGQSAPEDQSNGLDGGKDDLPESPSDPNMAEQRVFFTAYLSISLERCPQEFQCALVRFTELVRVSTINSIAFTFADTIELQHDEDGALVDPPEVLLATRIACLVSVPYQEKADEESAFEWAPVYSRQLCAFTVMSRVMNRSLRVLTEAIAAALFLSGFSDCSLEDYDSMAPLLPFGDVPSSLGGLLLHYVLVFPPDYEANCQTPEERCHLLETKFKAIPNIQTQLRRVMEFTFHALYLLNVYILRDPSIVSSPELVETDVVANALNLLHEKWELHLDGPAPEDVHGYFQFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQG1</accession>
    <name>A0A088RQG1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_211030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698890.1">
        <property type="nucleotide sequence ID" value="XM_010700588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQG1"/>
    <dbReference type="GeneID" id="22574925"/>
    <dbReference type="KEGG" id="lpan:LPMP_211030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210014300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_211030"/>
    <dbReference type="eggNOG" id="KOG1243">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="447103at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF3">
        <property type="entry name" value="N-TERMINAL KINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="693"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="823"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="712"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="825"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="849" mass="88432" checksum="DB151E030FB4DE59" modified="2014-11-26" version="1">MAFFLKALGLSDSIPGFPFTPAANDPGRAVYTSPQMCWTLRFGTPSDDAQTRVSIFTCPISSTTMAGSSGNSELLKQLAQNTIRRAKSLMIPGFLKCHGAVEYGDTIYIATEPCVPLKDVLESRELRRHYCGQTNEEYTASVAYGLDTVSGALAALQSNRLVHGNVHCGSIFISTVSGFWRLFGLEFISATDEVASGIPSCLLESARRAGMIVGYRCPPELGSSSGGDVSREDPVAAVDAWGLACLVYETVGVTAEEAINGRLNSLTHSLSAAELRNVCRQSLPKSLHQGCSNLTAPNPRLRKPIASFSEGCEFVKKSTFVQYMKALSELLLMDLSQQVHLAESLTGLVEEFPLRACLCFVLPRLGELVRAAAKTDGSTGATGVSIGPVADPVLRVAERTAAGEDFDEYVTPVLVQLYRSTDALLRYKLLVGAEAYAAKVSSASLNNTIWPLYVKGFAYSAPSVREYSARALVHLAPHMSGSILGDQVPKALAQLQRDADGALRANATIALNFVSEHITPPLQRAMVMLTYCRPMLRDAFEPSRVAALRSLHGSLECLSEKQLAELVLPAVSPLTVDPTSAESRTAALSLLKASLAKLEVHHKQLSVQQVTAAANRSTDASSTSLPVPVTVPAGTTSKMWGLLGGFTISSTSPAAEQCPQHVDAASTPMPSGAASPLHVTPAVTVLPTPEVTVASLEGGGGSGWSDDSEADASDKDDGERKANAFRGSSLFSKAPATLLHTPAAPFSAGTQPLSTTVSSAASTVSAGCGAHGPISSLPGLASSPLSQTIPTVSSASSVSSRTGINSLVGGIGGATPLGVGGGTGSATAGAASGPMKLRKKGGLGAARLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQX8</accession>
    <name>A0A088RQX8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_230670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699224.1">
        <property type="nucleotide sequence ID" value="XM_010700922.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22575271"/>
    <dbReference type="KEGG" id="lpan:LPMP_230670"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230013700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_230670"/>
    <dbReference type="eggNOG" id="ENOG502RSJ5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23244:SF493">
        <property type="entry name" value="GALACTOSE OXIDASE, CENTRAL DOMAIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23244">
        <property type="entry name" value="KELCH REPEAT DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1070"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1326"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1994"/>
            <end position="2019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2237"/>
            <end position="2267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2455"/>
            <end position="2477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2489"/>
            <end position="2534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2554"/>
            <end position="2588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2616"/>
            <end position="2754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2820"/>
            <end position="2848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2897"/>
            <end position="3082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3106"/>
            <end position="3200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3216"/>
            <end position="3290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3307"/>
            <end position="3420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="319"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1082"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2455"/>
            <end position="2476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2502"/>
            <end position="2514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2522"/>
            <end position="2532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2579"/>
            <end position="2588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="2616"/>
            <end position="2630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2682"/>
            <end position="2697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="2705"/>
            <end position="2725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2739"/>
            <end position="2754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2821"/>
            <end position="2842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="3019"/>
            <end position="3035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3065"/>
            <end position="3075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="3117"/>
            <end position="3129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="3245"/>
            <end position="3254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3333"/>
            <end position="3344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3366"/>
            <end position="3388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="3396"/>
            <end position="3412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="3442" mass="362734" checksum="1EE2F884A39C2845" modified="2014-11-26" version="1">MDDTSFLSGLSNLNEGIGETTYGRCISIFVISCEPSLDELAVRLGGPGCPWETVHLPMQQPVVLYCHPDARVARRATELAFATKAYAESPEADADDVHPSRDMVAMDVLTSTTISAAGSTLATCTVFAMSASGLVTELTAATEVLDGACDAEVARGALQPPLHVCIYWVIGEMLPGYTPPAVDETKTGESDDAEDEGTAHGWEDEKGESEGSRGGGAPAPLTPTALENVATIPLSPGELLALASPPQPAFTEVSVAVVEKRDGETTAPGEVPAHSTPTHDSNNGNDACPRKNHGTVTVGSEEGHWTSNGVTTNNEGSSAATPPAEMAAATVHDEEASDEQGGDVEKAAAGVSARSNSPILLGLFSAHDDVVAPAVTWTADRDDDGSGALALGKDGQPVASAAFPALSSPLHCKTPRRQRPRNYRSSTVQMEMFPEMARSSQGGGERDATTENSVQISEDDDDAENVAPAMAHIRLPLPLPPAEETVQSHVGYSAPQEVAPALDPDVMTHVQVSNEAATSYNNVLTPLSSNAVTDGALGHQRQAPPTLEAHHGTTVALKAPPSPRPTVENLFEGANSTALIVIVGVVAIYNASDATDPHRIVSVELTTASVDKRNTPDPPAPYTSTFSFCTMPALRGLAAAVPQVSRPVLLFSRSQNDANSTADDDGTDVAGAAADVPPVLHATCTLTEQVTSTEEGTPSDCTWTTLWTSAADVASGHGLPSLSAFSPASTSPISLEVRFTGDNGDVVLTQWTYMTVSAYRDAVLNLRSCVPGKVAQPVLQMLLIGEPRSKARKKMLSRRDPLMATVWVSSTSSSDSTRAGGVAHRAVAVSTAYDIVQQPVSVPLRGPLVYVAVQPSSSSSVWHSQPIFSRIFSSVWTPLTASLRDGDLCADSSSSHEAVLYYRVVDASTAAAAAELSWLPASPREEPGAFHKSSETEELREVTITVQPSATFIPALPPSTGRHTSTGISTVAGESNMAFRSASAWNLVLCHAMTRAVLAEASLAAGVLTYHCFLPVLRDRRTASGKCGSLGTAGIIRPGASSASEAAYLPWEVLLVPAAGLPKRDCGASTPSKLGAGAMRPNTRSAAPTTPSSRDGSLASPKATSVADPNAWSGPMWISSSALYAAPSIGTQWKTSICVSSPPASLTVAAPTLCSPPAALSSQFKVTCAIRSHTLGTDSAVFCLRSLRLVPSSVPCGVQAPPTGASLLSPSQVQLWFTTSGSSSEEVRAAWGTADVPSVKVVQHAWAPTVPTSRSYCTPALHVDAEGQLESTGLPVLLSTTNARARLCVALTTSAEITTASDGAADTEALRRCVAMVRKRAIHCYKKNHTSSNTEQGSHEGENQQRAKPQLTEEQMAEVFVQCVNAVAMSVDNYAEVDLSPSLVAASERPGKTRHRLLLSSVSGTIRMSHHMVLELQGQWIKMPSRVTVVSEDYMPSPRMWALRRSCVVRHPDLPPRAVCSRMGVSEEIPLTQKVLEAYMGYDVVVQSVPLDYTDPSEYAVQSRLPGLLYDEFVVQMKQQEEWLRPYCETVRIESSGPVAAPLRRGGRVAATAEGSANDNNDTAFKETAELFDNIFGPTGLAHASYVSGSSRKVAVVHFFFGDAYTTRTVLNVSCTTSAAARGKIANVPTQVYGNGYNPLPLSPGGSVPSMKKVTAGSAASSSSSVQVLCDSLTRSSTLYSVLPASIAVHQFPDESHHRYPSELTWYHGSLSIESEEEQRRREEGETAWKRGLAEERLGPHQKPSSLVVSAITQHPYDCLPLVVEPSLTRCADGRYYIVFGGLSTTTGTALSSVYVFDDTVQTWQRLRPRLSTCDMISLSTPAATPMPRYGHTAVYRPADGAIYVFGGRGHCDGAAALVYGDVWRMSWDAGAGTVAATELHCTWADAPSAAAGDSENHISFSMLTGDFGGRLARWRHAAVLHNDYIVVLGGQSSTGACCSCAEVLYLDLTTQEWTARRSFGTEVPCPRYGLTATVASGGAALYIFGGRGHEQSKAGPLNSVAHSGNPPRSDVNGDAADRDEEQSVVALSDFFKMDLITRMWSRVEPNGTVRPPALELADMTSCILDGCPVILLVGGRTNDAVVATPTAEPAGAAQLMVFLFSTATLFWRTVCMDCTPVAARFGLRVVASAVSAEALRLRRKTRNAQRADSSCVRRALPSRGQHIGSILVVGGLPLEEADVAQTPPVISVLLAAGSGSAAASRCVASVSRAMGESLSSQQRPLTPWPPTVSRATAMRRPMTGQTRTASCKPHPQPPGHHRVPATAPGWPNTFPSMRAGGDGSYEYYGAAGALALSTTSPVAFCHLAEHSPGPSSVSGRATTAPTPLGLHHHPSCYSTLTPWQQRRLVRRLYTQGIEKRAVVRQQMQAQVDKERSTPAFRANRSWRRSPGVRRSLIQAGQLSAPLHRPPNGTTAAVSEASMLPAAQNTIAANVGDCANVSLSHRNLPNAFHVRVRRSGSTSCSSSLTTSSSIRSSVSSCGDSEWDAEVVELPPENASSTGLSGKGDKSDSECAKNVEEEEEAGAEASEVESVASEPDDALAGTAAILHDNSAKAAQKEAVVAENESEASKSWEENDDHFENASSGNSSAVLQSRNAVVTSTGATVLIPMLWYVPPADMENEEEKVEGEEDDASVATSSEAFAAPVASSPSHTDEVSPDAEVEEERSREVEQQAPEEPATPPLAPLVANGNAVAGNEAAATPISLETREEEDEVNSMEKDDDYADADWENISKAEESDDHEDGVKSESSAESRSAIREVVEGSQEVLTPLLAPREHATLLLSPLPQEACYMSEPTDHEMSSDRVTESVDDAKVAVVPVEELSEVATTSSLSSPTEAAALPSTNPDSYAHGSDVAEKPFGAFSEEADFPNIADEGDGMYSRASSLADVLAVVVPAVEAPAAPVSSLQSSHAGAEQDNSEVSSSPAVGTPHLAAVEEDDKAKAVLEESQQNTDAVVEQLPATPPTPSSTSFAVPDPAAESPMPASFSYNRGDSIQGAEAEALHTTATPPQEVVELPLAGPADIGDGDASDEVETPIDEGEVATPPLVAEQPEEKARLSDVSGGEDVVAANTAQPSDQQRITPPPSILSDALEGLAGVPSLLALSVANEHVDDAGEATTSPPAHEEPEQIVKEDTSVLELEGSSWGDQADGPAVEAVPAEDRSDAEHEEEDAEELPCPGSKAEVEESQYTEKLQDDSDLSELSGVQDGAVKSGVAAAADVNKEAVKQSSAAMMQPQHGGMSMGEEQVDAPVTASAAVSSVHNDGDSALSTPAASQGEEKREYGDWEGLNEDSGPAATFSNVEDAVVAKQSVSAFPMPTHEETPDSWSELSPAEEDAPLQENQFAPGSAESSKSKKDDVVLLSDEVNAWELSTPASAASTYSKEETPATQANASLPPQVVAEDAYEEPDTQASSEEEVEGTTVELNDGRDLLDRRRGVVETLQEDDFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RR53</accession>
    <name>A0A088RR53_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DNA excision repair protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_231430</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699299.1">
        <property type="nucleotide sequence ID" value="XM_010700997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RR53"/>
    <dbReference type="GeneID" id="22575348"/>
    <dbReference type="KEGG" id="lpan:LPMP_231430"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230022300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_231430"/>
    <dbReference type="eggNOG" id="KOG2518">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26491at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09857">
        <property type="entry name" value="PIN_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000124">
        <property type="entry name" value="Exonuclease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000093">
        <property type="entry name" value="Exonuclease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044752">
        <property type="entry name" value="PIN-like_EXO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF65">
        <property type="entry name" value="DNA DAMAGE-INDUCIBLE PROTEIN DIN7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="8">
        <location>
            <begin position="211"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="607"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="856"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="859"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="877"/>
            <end position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN98592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1009" mass="108500" checksum="DF79FB4A9144D069" modified="2014-11-26" version="1">MGIKGLWQALREYVDDGHLSQFRGQRVAVDMYVWLHRCVHRSVRIRTEAVIAFFDAKYSSITGSTGADSLDSRGDTATLASPSPAPLSLDDILVIDDQFVTLVLDKVSALQRFGVIPVCVFDGAEMPMKGGTDEERQRRRAEAFQGALTKLEQLYCDARRRRGCTAEDHADGTRIALPRDTRPYEEAVQLLAKAADISTELAHAVIQVLKEERHVECIVAPYEADAQLAYLCRQGYVVAAASEDSDLIAYYCPCIISKLDTFSGKCEVLQPPLCAPHFFRRMAATRVTTSTAATMLLKSATANRRAAAVDDAIGHGHDGVNSVHARMRASALKSLQCPHYSFNGAVGASTDEGAISAAVATAFTYESFLLGCILSGCDYVPNLRSIGVKKAFKLVAHATSLRQCFTTLEREFGFPADELRRYRHRILEAFYCFAHHLVYSPLTQEIVTYHPLPGTDRGGTAELKTRLVGQRWSAQIAQEVCVQCLKDPCTLQLYRGVYQPCVTQYLQRTRRGQTSLRAYAGFQEMSSSRVVVHVEKQQRDGLATSQREHAQCSFGPPLKKQRVASGFLGSSAALPQTSSSSQQPAEVVVVRSRFFMVRGRTAVCEQWSTSETDNEGDVESGESKEPMVVPRRAAVCPADPMIDPNTGCRSPFSSLAHRPSSPALLSITRAASGTLTDDSASGVGSTVTSTVRCTAGMTGANETWEMSDVRNTSDCARRDETAESLSTVSWMGMDGASASAASLLCRTSSTLFMGDSESMRDEECGVEGEDMARHAPVVREGARKVGGLTEIPGVEPYVHGIAQDTNSTVEAAGAQGMSSAPSPPRCDCPFGYWQCNRAHSVFESCFVGRHWSHDEGPLPSSSLERPTARASASVTGSSATLSPSPASPLQRLAMSPVGSVASGYVSRAFRPPRSTAAASAPPLPAAGKSQATPLYVCNTNAKGVDLAVLRSSSKAEPLAAAPLTLLPSSAFLSSPADGDATSRAAPPPLPTPPAAVHVAIFEKMSFKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRE4</accession>
    <name>A0A088RRE4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_202940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698496.1">
        <property type="nucleotide sequence ID" value="XM_010700194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRE4"/>
    <dbReference type="GeneID" id="22574504"/>
    <dbReference type="KEGG" id="lpan:LPMP_202940"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200035300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_202940"/>
    <dbReference type="eggNOG" id="ENOG502RGX4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271179at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="533"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="559"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="621" mass="68891" checksum="92DFA214E8E8BEB2" modified="2014-11-26" version="1">MDDLPLSSSTTLEISPHYLGGVRDSLGHLPPWYQVLSLGGVFCVIHLRNNAVVTWLVVELHSSIGTEAVWPDEYQTILRAMSFTERLCFTLYGATLAAIAVLLFRVFCQDTWNIGWNAGQLFPDKKLPSIAMVVLMCVAEGVRLRQVIGQQLCTPGSLARLAMHSFNEIERSKIDPQIAESNTHVVIQFELFRAYLAQACIHRIPVVLFAGAYRLFRDVPNKAYVALRWYMATIAGFTVVQEVLVMYIRYVWTDWSLWAMVIWSLAFLGVVNFVYGLSKRAGMVVTMSTTNCVAEALRGLVTCSALWFIASLIVLAFVVSVHEELVLIWLFMSLMILWTPAIIDACAIDYMTFLAIGAGCVVYAMDGVSSIWASIRFGALHFLWWLFVSLLYNAALHVSASRYIAMTVAAAWFLWSLAPPRELWKNAESAAELGLEDGYGVVQLFTARVLWLRAVADFGALPKGSWIYGRTQGDGRHAFDLLIHASVPACGLCVVVSSAVQHRFTAATRLEWQQQNIVSATPGVLLRKIIRTLVVVGCVVASIGMWCMVRFYVLPMWTLLLPDIITKALATVAAVTVLGNLMDMQESMYIACLRIAGLSDTLPTTEEQTLASKDLARSGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRE6</accession>
    <name>A0A088RRE6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Guanine nucleotide-binding protein beta subunit-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_240120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699354.1">
        <property type="nucleotide sequence ID" value="XM_010701052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRE6"/>
    <dbReference type="GeneID" id="22575421"/>
    <dbReference type="KEGG" id="lpan:LPMP_240120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240006000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_240120"/>
    <dbReference type="eggNOG" id="ENOG502QY32">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1068471at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001339">
        <property type="entry name" value="Guanine nucleotide-binding protein beta subunit-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051179">
        <property type="entry name" value="WD_repeat_multifunction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857:SF21">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 4 WD40 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857">
        <property type="entry name" value="MITOCHONDRIAL DIVISION PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="555" mass="60878" checksum="7E5F5E2ADF7B720C" modified="2014-11-26" version="1">MKITVNVELEHSELYKAPHLQQTVSELDSNAVVRFKTDTGFLAQRIKDAVKTKQYDAIVSELVRRLSYPASFADSLEVMCSIALFSKGRVDSGESVAPFVEVLTRLPEEARTQAKEAIVQRAMGFLSKPRRLDCSRAPLIGYAETLAMMTRKDLLNIRSAVNTLVQMIEGDTTRAAGMTCLGKLVEVAYEAVRNCDTATLNVLRGAVRFAQMNDTFLYDVEYIMEALGWSPYKPALSLRRSSSHHEYPILSLAYCGGANHREVVVSSSSDGTIGTWDGVGVLLQNVLLSRHYASCLDITNRGHTLIVGAVGRYASIPPAVIFYSEDGNRKAQWQECGGTEPDDAQFISSLKSLKDSSGSRYCVGVQTSNANSLMIFDGQHVTQRYFDHTDLITALHVPSDRENMVITGSRDCSTLIYDLRDPRNVSAATHHTNTVSCIASCDNNLFTAGLDKRIVVEDFRMLRSPNVQRDMDSAVLSMSVSNSLQCAVSTLTGVYLINFSSSTTIPTSSRSDCGGSASRYNAVCWNNAGTILFCGGDAHTLDLFAPAYELNSFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRF5</accession>
    <name>A0A088RRF5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoside triphosphate hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_230340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699192.1">
        <property type="nucleotide sequence ID" value="XM_010700890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRF5"/>
    <dbReference type="GeneID" id="22575238"/>
    <dbReference type="KEGG" id="lpan:LPMP_230340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230008700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_230340"/>
    <dbReference type="eggNOG" id="ENOG502SKRC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3512845at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046404">
        <property type="term" value="F:ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046403">
        <property type="term" value="F:polynucleotide 3'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057680">
        <property type="entry name" value="DUF7920"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083:SF9">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25536">
        <property type="entry name" value="DUF7920"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7920" evidence="2">
        <location>
            <begin position="33"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7920" evidence="2">
        <location>
            <begin position="188"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7920" evidence="2">
        <location>
            <begin position="483"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="694"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="860"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1103"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1103"/>
            <end position="1115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1226" mass="132646" checksum="A54DBA7F1202F355" modified="2014-11-26" version="1">MATAAHLISATTMTGGPHNQSFSKLLASVLDEEQRRCVNAAYHISFHRDPRVKLKPTAVVLPNGVHFLIVDRFVSGNCDGVYEKNKKMWEHIPVGQACVFARTPVAVPVLSLGKSAHEGCEGSGADTKAIAAWPCPRRSGSPIPVAVSSPSCSPPIAPLPTANAFGSSSQSNRWDSSLPQQHAFHSEWTRVASAVGLRKMGHWREATSVFSIHKEVSKTAIALEKVDGEPGRIAAFSWLGEHYWIIGSRYQHIVTRLSIPEVDLMQYSVSSISSASTPSSSSSASEDAAVSAMASSAGQPYASSSGNSPTQNPHDYVEQSSVHSSTIAGGAAALAGSGASSEAAYLGLAIRMARMWRHVLESLHIITEDVARAPNTASASDATTAATSTDVLRELHACMAADNRSLCFDVIVSGWERLQNFVTARDSPVDQPTVATSTPVSCTSIGTYRTNSTAFMMISTPVTGDSSTPFSTCAAVSVAIPMWFYAITWDASLDERGWCMGVKEAFAFFERFRLPTVAKSADVQLGSPEYEALRQSVLSRCDTAGAVMYGWNSDGTDGGKPALVVQVWKCRAYPHSLERTVQEYVVTHRLCGEPLRCKVKKKVSSLSREVRLRIKQWELRRLPFLLDFALWLHREKYITPSTDLVALKVIRGHWLSYQERFQAMLETQLQQRHRGSSRQGTTASVPEVVRVRHGTGADTTDSRHCSGRCDNADGDAENSDRYLQVQREQDDESLHDAESLDPIILVGPQGCGKSTMARTLYALLEEAGAAPRWLNQDEVGNRSAYLTAIRHTVMQGGYSHLLLDKMNLDDKSRSDYAAVGLKPVLVVAWTHTQGVEAMVETCYERLVKRGVRHRTFFPEDVAPLNPSPSPVSSRSSELDPTVSPLLQGHLSSLSISVDTPAAPSGTVPLSSARTGHCVCSLSVPSPAGRSSPPPSSRLHGILHANAKRYQMPSNDTLVELEVTWSCQRMVAVVWEALRNKGTCVLPPLEELHMEAAMQSSYAYEQLLETYPSRVASAVLRGPTSDVVLQQLSLVLPPLTIPKTQRLQLHVDVLLHNFCLHPSPTALVRYASQVGHTRRMTVQAVVSNSKVSLLLILGPTETAAEDSATSTATPAEGETSVVSMHAGPTQPSLYSSPSAYNSSGEAAAIGEGGLGVSPASGIEDPSCVAARPLQEHFAVLSKAKVKPDYCEALAQRVRDDPDADPYCTVQWLSPPLEIDCSVTLLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RS43</accession>
    <name>A0A088RS43_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_241510</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699490.1">
        <property type="nucleotide sequence ID" value="XM_010701188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RS43"/>
    <dbReference type="GeneID" id="22575560"/>
    <dbReference type="KEGG" id="lpan:LPMP_241510"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240019100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_241510"/>
    <dbReference type="eggNOG" id="KOG0936">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261046at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000001">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="7">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN98783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="166" mass="19195" checksum="C1B8230DB0C6D05A" modified="2014-11-26" version="1">MIKAVLIINTAGKIRLLSFYEKTISLTQQQELVRSIHRAISRRGDELCNFVDNFKEWPTPDTRIIYRRYATLCFVFVTDSSESQLAILDLIQVFVESLDRTFENVCELDLIFHSEKVQYVLMEMIMGGLVLEMSRDEIIRSLGEMSRLSAKMTAENTTSRTLSGYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RS63</accession>
    <name>A0A088RS63_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_251140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98977.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699684.1">
        <property type="nucleotide sequence ID" value="XM_010701382.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22575762"/>
    <dbReference type="KEGG" id="lpan:LPMP_251140"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250017600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_251140"/>
    <dbReference type="eggNOG" id="ENOG502SEAT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216">
        <property type="entry name" value="PAXILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98977.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="6500" mass="682640" checksum="8FCE419F4ED23528" modified="2026-01-28" version="2">[encoded data, 6500 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSV4</accession>
    <name>A0A088RSV4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pentapeptide repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_260680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699889.1">
        <property type="nucleotide sequence ID" value="XM_010701587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSV4"/>
    <dbReference type="GeneID" id="22575971"/>
    <dbReference type="KEGG" id="lpan:LPMP_260680"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260011600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_260680"/>
    <dbReference type="eggNOG" id="ENOG502SAX5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273772at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="521" mass="56420" checksum="995D6AD3908071D2" modified="2014-11-26" version="1">MLLRKYFTAVHRGRGAVTPIFFRLTAVWTKRLFSAAHDGSGCEEQTHLCQPSDPLRDSIDDVRQPHHRRCHARLMASRDRYRGAVPSQGRRGRSQKGNAVRVLHQTASKQRRHGATSRPSRSSSPFRNTKTHDAIRTSLYALDKAEMLDAMLALSSALYEGEAAATAVPVSGANASNNVADYAVFSSRVPPLTSSSGLGELEGVAVTGEEAYASLDAENLMCSMDACSERCNDERDVRAVQADLGTTTSAVPPFSRTAVAHPSTAGTSSSSIMATFASPDVPLERKLLQFMDLCSSTSPKSHLGGDNSDAASQRPWNGGAGVRVGNCRSDCTASSVATAWTSSTAAALVLPGLDMKAILAHGVLENRHLRGLSLVRCDFSLVRWSHVTLEDCDLSRSLFYRVELDNVIFRRCNFTGCILKGVQCNPSLSPTTHFEDCDFRLAAVGLLCIPHGSQRSGQGEDQGQGISSSNHRSGPSVCFLRCNFDLSDFQFSQGLEKCRFVRCSNTHLASRFPLRARGSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTR8</accession>
    <name>A0A088RTR8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dynein-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_271620</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700249.1">
        <property type="nucleotide sequence ID" value="XM_010701947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTR8"/>
    <dbReference type="GeneID" id="22576340"/>
    <dbReference type="KEGG" id="lpan:LPMP_271620"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270023500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_271620"/>
    <dbReference type="eggNOG" id="KOG1587">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="366230at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036156">
        <property type="term" value="C:inner dynein arm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060294">
        <property type="term" value="P:cilium movement involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036159">
        <property type="term" value="P:inner dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001782">
        <property type="entry name" value="WD_domain_-_G-beta_repeat_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF5">
        <property type="entry name" value="DYNEIN AXONEMAL INTERMEDIATE CHAIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="316"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="744"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="316"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN99542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="792" mass="89125" checksum="FB498833A12E61B1" modified="2014-11-26" version="1">MALVTQELLQVAEELRVVVPRGTWQSYGSEEEIRKQKDTDRVGAPAIPSRLPITVHFEIARQAILRHRTSAHNGYITKEANEDSRDLRSVDNPLYEVMRDEVDTGVQAVPRRTTASTQTHHARRVNAVAQAEPTVVDACIRHVPPPKEEQPNLRAFLDKVLPRTLLCLTQNYQVPIYTDDFRNFNEDDAVIATHDELVLIEKANYVHNSTKGRKVSGVSWRSGRRRDHFVCVASIALQTLPERLQANGRCESSVSLVWDLNDPMHPRYLLEAPEEVQVLHFHPTRPSLVAGGSLNGQIFLWDLSKADVVNFFSNASQHQQSQKPQSNAAAVGGGSGEAGEFREVSEVPRMPDSLKGISLEVDGDVRVPRLQPSQQSRVELSHQGPVHDLQWLPEKIEFGFDGKQTVVNETHQFATLSEDGTMLVWDTRPQHLPQDKLRKIKHQSRTSSNEQPWVPLLRYQLTKPDGTGEMPGFRFFFNGCSVDDSPSYAAVVASTDGELGFCSMVAQHERRSSIVVPTFGYTKDTRFVRSVAPSAHAGPVYCVERHPIIGDVYLTCGDGCFKVWRYGLLMPLYECPQRPGNVMCAAWSPGRPGLIIVGTGNGMVEVWDLLDRNPEPMLTHHLVQDAITSIAFQPLPHRVTRRYTQQLLLGTNLGSFHWYVLPPALSRASNGEKKYVRAMLERETRRVAYYDWRWSERQSEIDRFGLQGAAERLRGTIAQTASSNGVAALPGKENVDATDSLLAERRPVKEETDLGDLNNPYAQDPQRDEEFLELVEKLHRQELQRMESESTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RU22</accession>
    <name>A0A088RU22_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dynein axonemal light chain 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_241010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the dynein light chain LC1-type family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699441.1">
        <property type="nucleotide sequence ID" value="XM_010701139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RU22"/>
    <dbReference type="GeneID" id="22575510"/>
    <dbReference type="KEGG" id="lpan:LPMP_241010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240016100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_241010"/>
    <dbReference type="eggNOG" id="KOG0531">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266138at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000049">
        <property type="entry name" value="Dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF73">
        <property type="entry name" value="DYNEIN AXONEMAL LIGHT CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0243">Dynein</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN98734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="210" mass="23765" checksum="D12BFF1581CF2F91" modified="2014-11-26" version="1">MASATSIKEAIVRFEESEYRRRLAGVPEAAQESVPRVVAAQEAKVLLIGMLPPIAKMDKEISTLKECVHLGLSTNAIEKIGPGLKELKNLKVLSLGRNSIRKLEQLDLPQLEQLWASYNKIDKLTGLDKLKSLRVLYLSNNLINSWTEIDRLANQCPELVDVLFLNNPICNSAASNQEYRYMMLQRLPKLTRLDGVPVDPEEKEEADRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RU31</accession>
    <name>A0A088RU31_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA processing factor 1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_270440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700132.1">
        <property type="nucleotide sequence ID" value="XM_010701830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RU31"/>
    <dbReference type="GeneID" id="22576220"/>
    <dbReference type="KEGG" id="lpan:LPMP_270440"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270010900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_270440"/>
    <dbReference type="eggNOG" id="KOG2780">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000006">
        <property type="entry name" value="RNA processing factor 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF3">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="125"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="330" mass="39396" checksum="633C466392F7FC3A" modified="2014-11-26" version="1">MGKGARSKHRTRPYAKRQHVLESKAQEVDPELLERYRNTQQPIRKSQLFTEILKQKKDTKRARRESRENERLHLKDKAPVKTTPKTKERKRRVDVTILENKEDAEIINDEADDEFAAFFRDRQNPRTLITTGEHPCFRTKQLVKELLWLVPNSIYRPRKSYTLKEITQFCCNREFTNLLVVTDRIKEPHNLIVSHLPEGPTATFRVSNFLSYAQLEDPAPRTEHYPELIFKNFDTRLGRRIARMLECLFPATRDYAGRAVATFLNQRDYIFLRTHRYIFDSLKAVRLQEMGPRFTLRLLSLQSGAFDRQFGEYEWYRKKEHDADTLEWYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RU80</accession>
    <name>A0A088RU80_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Isobutyryl-CoA dehydrogenase, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LPMP_270910</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2S)-2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48256"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57337"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:88166"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:48257"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>propanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = acryloyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:31287"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57367"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:31288"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700182.1">
        <property type="nucleotide sequence ID" value="XM_010701880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RU80"/>
    <dbReference type="GeneID" id="22576269"/>
    <dbReference type="KEGG" id="lpan:LPMP_270910"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270016300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_270910"/>
    <dbReference type="eggNOG" id="KOG0141">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9988775at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008470">
        <property type="term" value="F:3-methylbutanoyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000001">
        <property type="entry name" value="Acyl-CoA dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase FadE19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000001">
        <property type="entry name" value="Acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF12">
        <property type="entry name" value="ISOVALERYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016578">
        <property type="entry name" value="HsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="14">
        <location>
            <begin position="38"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="13">
        <location>
            <begin position="154"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="12">
        <location>
            <begin position="257"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00071686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AIN99475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="410" mass="44550" checksum="4F8B2F9D1E12530A" modified="2014-11-26" version="1">MHRVLQSSLCRCTGTCGWTAAAAMTSTSRTFMDLYNPTPEHAALRETVARFSREVVDKHAREDDINSHFNRELFKQLGDLGVMGVTVPEADGGAGMDAVAAVIVHHELSKYDPGFCLAYLAHSMLFVNNFYYSASPAQRARWLPKVLTGEHVGAMGMSEPGAGTDVLGMQTTAKKDSYGNYVLNGSKIWITNGTVADVYLIYAKVNGKITAFVVERGMKGFTQGPKIDKCGMRASHMCQLFFEDAVVPAENLLGGDGKGMVGMMRNLELERVTLAGMAVGIAERSVELMTSYASQRKAFGHPISNFGQIQRYIAEGYADTEAAKALVYSVSHNVHPDNQNRLGSDAAKLFATPIAKKVADSAIQVMGGMGYTQDMPVERLWRDAKLLEIGGGTIEAHHKNIAKDLLKGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUU0</accession>
    <name>A0A088RUU0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_283000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700639.1">
        <property type="nucleotide sequence ID" value="XM_010702337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUU0"/>
    <dbReference type="GeneID" id="22576745"/>
    <dbReference type="KEGG" id="lpan:LPMP_283000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280036800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_283000"/>
    <dbReference type="eggNOG" id="ENOG502S6ME">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272830at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="421" mass="45425" checksum="EE020CD93D12BBAE" modified="2014-11-26" version="1">MSASPLVTVTHSASRPHKDCITRFASFDALCHAQQKSDAHALLRKELEAKLPQPSPRNDVVAVGDAVIERVLQFLGPVSRNAAAFAQTCRLVRRALLQAMNLEVIVVTPTMVAASALSRKSVRRALITFAAGRSTQVRTLVLQEDSLKAVKRECNGGTSAACLTLPAPWVLQLISQLPYLTELDMRHVQLTEAHHSQVLHYLLSDLHLAAVGTLCTLKVDAEVMRYWAPGWWRRLINLSSLVVGSRYCPPEPTSDATAISPSLLELPADYFALMGEEDRHWQLKLWVPLKAASLKQILMPASGTSFAGVVELLVNMRHNERTCDWAEAAAADTSPLPSSAAAAALCKPGTAAAAGTELGEPFVYPALTTMTVVDVQERPEVAADVCQALLAMAPALVHFNVCDSVSAGTASEPPKKRHGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RV12</accession>
    <name>A0A088RV12_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_252360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99099.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699806.1">
        <property type="nucleotide sequence ID" value="XM_010701504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RV12"/>
    <dbReference type="GeneID" id="22575884"/>
    <dbReference type="KEGG" id="lpan:LPMP_252360"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250025700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_252360"/>
    <dbReference type="eggNOG" id="ENOG502SAYA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269633at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99099.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="30069" checksum="939C4D3D4C5555CE" modified="2026-01-28" version="2">MASPHRVGVLDPGCHALRWVSRHQGYGARGTFVELVHFIAYFLPPSTLSLCLLPSSSCGVLHTTPPILFLLIIAALQHIVPSPRFLCSIGYWGVLAAHVRVICAVSWRENGGGGRLPHRFIQDRPKRLFLLAQTRYLLSQSCRSAPMERERKLAEREVREVVADAESPLAQRHVRESLKKNKFALVLYAIALFTPAFFLISFYTAKAREIRTNFRDPYALPEGFDPVTGEFASQEVQSKGAHALPMSSSLFVGEELGSYGPRTRKRSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVU9</accession>
    <name>A0A088RVU9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine protease</fullName>
            <ecNumber evidence="11">3.4.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ATG4.2</name>
        <name evidence="14" type="ORF">LPMP_300280</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine</text>
            <dbReference type="Rhea" id="RHEA:67548"/>
            <dbReference type="Rhea" id="RHEA-COMP:17323"/>
            <dbReference type="Rhea" id="RHEA-COMP:17324"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:172940"/>
            <dbReference type="ChEBI" id="CHEBI:172941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:67549"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase C54 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.-" evidence="11"/>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701063.1">
        <property type="nucleotide sequence ID" value="XM_010702761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVU9"/>
    <dbReference type="MEROPS" id="C54.007"/>
    <dbReference type="GeneID" id="22577082"/>
    <dbReference type="KEGG" id="lpan:LPMP_300280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300008100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_300280"/>
    <dbReference type="eggNOG" id="KOG2674">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2960936at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019786">
        <property type="term" value="F:protein-phosphatidylethanolamide deconjugating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035973">
        <property type="term" value="P:aggrephagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005078">
        <property type="entry name" value="Peptidase_C54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046792">
        <property type="entry name" value="Peptidase_C54_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624:SF49">
        <property type="entry name" value="CYSTEINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624">
        <property type="entry name" value="CYSTEINE PROTEASE ATG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03416">
        <property type="entry name" value="Peptidase_C54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0645">Protease</keyword>
    <keyword evidence="8 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase C54 catalytic" evidence="13">
        <location>
            <begin position="44"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="360"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="386"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIO00263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="398" mass="44415" checksum="2321F306D51DDCCD" modified="2014-11-26" version="1">MLRYVQDLWSAFFPTEAVFPLQVVGRSGAAVESQEELGKALADTFLIFTYRDGFEAIPAVTRLIETDQGWGCLLRTSQMLLAHFLWAHGRPADRRLALFFDHSAETAPFSIHNLIRSVWNQRAFKAEYWSPSQGCEAIKRTMQDAIRTEQLQTRVTVVTSTNGCVYADEVHHTFKQGAEVVLVLASVRVSAAAQLTQESYLQIEKLMEQPQCLGIVGGVPGRSYYFFAHNQTQLFYLDPHQRTTAALLSDGPSATVSVTPSVSDVRCVHWSRVDTSLFLAFAVTTRDEWAALEVHLSNRFMHVESQRSLHDGDQFAPARQGHTNGTFVSPLRMGNRCEMNGAAGDLPLSETALLVQRRTLRVPRGRRQGSEAGTATDATAERNAGEDELDTDSWEYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWD1</accession>
    <name>A0A088RWD1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_300960</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701129.1">
        <property type="nucleotide sequence ID" value="XM_010702827.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22577150"/>
    <dbReference type="KEGG" id="lpan:LPMP_300960"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_070008100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300014800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_300960"/>
    <dbReference type="eggNOG" id="KOG0942">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000027">
        <property type="entry name" value="Ubiquitin-protein ligase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000039">
        <property type="entry name" value="Ubiquitin-protein ligase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF2">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="530"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="9">
        <location>
            <begin position="1048"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="609"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="624"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="1359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIO00329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1391" mass="152545" checksum="E4C2FA2EA367CC6B" modified="2014-11-26" version="1">MSQFVFNGTSRMRHMKLARDHHKTRNSIIEDAQRLRLQREEEAQRIRAARLLQRTIRQWLACQAMVRLVLSDLDNLPSDVTRILLSTSSDGISSAVDRPEAERQTEQLTARLHTACWCLSYARSHQSRIPLRLTVSSACAPNDDCRAETPVGDASSGASGATGQGATTAAHPGVALSSTRIFSVASFGELRAYQQRVFWHYSECLYTALCKSINHRTGGEESAEEDGIALHADASVEASADNRSADPPSLSWSSVVFLPTKDVIVLLCVVLQHFLRAAPSATGSRSPPPSSASSVKRLVRSVVAALVEHNTAFARTLNEELAPRSSDGCLERVATSFDQWPAVHALTVALSFLCQEAVAHSVSMRSQCRELLQPLAAAFPPLSQAEAGGHSPPSPPMGAFARVCWQCMCAPYAGEESQRLTSNSLAVLLSAADTAAEGFERGGCGEVDTCFTMLVAECYRRTAMDTELTADDGASGLRGGELRARVLGRLVRLLPRVHKLVETTSSSAAAVSPSSVAARTDLVKWYLLSVSCLSERLCREDFFVEGILADHYAYHTGRRQQRLLVDRKDDDVSVDASLPSQYRLLTSYLFSAEGGLQLLQLLTEQDERSEKLRLQAPQEPTVEAPTDPAAPPMADGGNEESDSAAAASIANTASLMDAGVSAAAQWPSSASMQQSPLEILCNVFAWPIFTFSKPMYSRYQQETLALYAKLVRTPQLLRRLWSLYWQSCEGLRAVLPPGEVLQRLCQPPAWGAQEREEQAIAAGQEWGRRRRVPAGVHSARSLMPLPRLPAWETHPRYPLAFYDPHASLSIFFFTLLAYYVNVFDFPDELRRGGEGAVLSTEESWALVLALKEIVHRSHMYGVVPNSNSEAVAHAACLLLSRLHTVDEADPFVPAAAAGLWMSVGAVAAEASVGLLFRTWDAASAAVVNEEDTAEAEGPGLDGASVGTGGRSVVGGLASSTTAGTTTTSIAHVRLPGDDVTFHGSAQWKQQIRYTKLLVHTPFLFPFAARALLLSALLVETDHHWIPPSERRVVVQRGRTFIDAFNLFHDNPLSNDMLNIRFIADDGMLEPGYGRGVYRECIVSLCKEGFAAEYGLFRQTPDGYVYPNSFSALATSDPQHLLKIRFLGAMVGRALRDGVLQDVPFALHFRNAILGRRNTLSNLKRFDAELYHQLMSLTQLSEDELKAVGLTFVYTVNALGITREVELVPDGAQMDVTPRNCLFYVHLVADFKLNREAAEQTCAFCAGLRSVIDANRLRLFDSNEVGMLFGGDETGEIDLVDWKENTVYDQPEDVDTPQVRLFWDVVESLTREQQRQLLKFATSMTRPPILGFRFLAPPFKVQLLAMNASGPDHLPSAATCFSTLKLPPYRDYATARAKIIAAIEETGTFEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWE7</accession>
    <name>A0A088RWE7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_292840</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700888.1">
        <property type="nucleotide sequence ID" value="XM_010702586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWE7"/>
    <dbReference type="GeneID" id="22577047"/>
    <dbReference type="KEGG" id="lpan:LPMP_292840"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_030014700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_292840"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000904">
        <property type="entry name" value="RNA-binding protein RBP6, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="113"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO00231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="210" mass="23516" checksum="A286FFE262E94BF2" modified="2014-11-26" version="1">MYLPNTNASSQIMQFPSNQSQQQFSAISSYSPQQQFIVQHPQQQGVYQTQNPQLVPMNIPSQSNQQYVGGPTGTIYEGGVQGSVNQTSPEHNAARHNRTQMIPVPSNDERYRKQLIVNYLAQDVTSADLHTLFARFGPLDGARIIFDRQTSMPRGYGFVYFRYPDSAKQAVDTMNGYEFHGKRLKVGYSTNPLNIISSAPSNQYSAGQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWF8</accession>
    <name>A0A088RWF8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromatin target of PRMT1 protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_300100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701046.1">
        <property type="nucleotide sequence ID" value="XM_010702744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWF8"/>
    <dbReference type="GeneID" id="22577064"/>
    <dbReference type="KEGG" id="lpan:LPMP_300100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300006000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_300100"/>
    <dbReference type="eggNOG" id="ENOG502SAPZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268064at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="23926" checksum="BC4B1C11D1B58474" modified="2014-11-26" version="1">MARDDFDRRRLRALYDRNRRRVSALADARARRRGGEDDYSVPRRYVVSECRTRIEGFGRGGTQVRRVVRRARGDRSDESRRFSGRGIFRSSGGSRFRRADDFEREERRARFLEERVRRLGGRHAEGRRFGVARRMRLRMRGTHGGRGNRHLQESSRPSNGNSHGNRGSNAQANKVRSSKKPQRSREPQITREELDRQLDNYRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RX59</accession>
    <name>A0A088RX59_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CPSF-domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_303670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701389.1">
        <property type="nucleotide sequence ID" value="XM_010703087.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22577420"/>
    <dbReference type="KEGG" id="lpan:LPMP_303670"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300041800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_303670"/>
    <dbReference type="eggNOG" id="KOG1897">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="433457at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="2">
        <location>
            <begin position="528"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="1">
        <location>
            <begin position="869"/>
            <end position="1252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1347" mass="144415" checksum="466ACCC05F9BBFFE" modified="2014-11-26" version="1">MYVVSTSRPSTAAFGAAVGRFCGGGTTYVALNRGTLLSVYACRQGNSGIDHVQDFHMHCTLKYVRAVLVVEGTAPQKSSRHLLFLCTYKQEILLAALETSPDLSGGAPPLRMTTLFQSEPTDCLYQYDPSEVELCSCSSAVSGAGAQPPFVAFALTRGELFLFDVFAALARDAVKRKQNGHLARLFSPELVAHVARRARADIFSHCYMDCSEYDVKDISFGSPSPWLKGQTHGATQRPSAMGARGDSASASISLYVLYGDPYGKVHIAEYEVAFSAVTEMEVAGDRKGLGSSIRQPLTPPPSSVEFALLGRRVRRCGLLQPNVDPTAAHIVASRHGLFVVGNHLVTLIHQVRPRKGVYSREIPSRQAILDVSCASVSADASELVIGFRDGILARVTVISRGMSGEDPVLEFRFLPHPTPTTPTEIVTLQGDLCLLCSRFDSSFTVRLDEASCEEVLHNCGPVLDMSTHQSGAQCSVVAATGIHRGGGVSVLRSAVMLREQASIPLRCHPQRVLCGGGLMCITMTAAANRFFLVSARALTLEELGPHVFPAIVSHHLLVELGLGAAAGTLVLISVRGIAWLRLLGSRCEVVSQLPRQAGDPDILFAAVRHGLTAVCDGTIVTVYRGQEVVCTVPSLADVAVSAVSLVSSALLVVGQWNGVVALYEVGCRHAEVVGRLLLDAVPRSVASALPQLSPSPVVDESALPTIYIGTHHGFLVETTIAQLRDGEARRSVFVAPHPLELLELGGPHAGLLCLGNVPLVVLCGAGGGVQLTGLHVMGVSAAATVEADLQCYAFYSKLDGRLHIGSLEALEKTSRTFLPLGETVTQLHETAAWGGYAVAVRKVEGDEVLFLPSSVIQSPWTADLGLWRTAAVPLLENERCVFLQTVRLDGSEGGGPGERCGEQIDVPANTSAGVSEEDWQHLLLVGSSFTFPDEQRARSGRVMWFALDEERQGQRLRLIASKDIGGALQCCAEVPYYKGRIALGVNGCVCLYKWNTEDQTFVAEERCRVGLTVTRLIPLYNTALAASVLVALDVRHSAFLIEVDLLQGSLKVLCREANLRGVMDGYVGSDAENLCLFDDNLNFTALKVVPLPVQPGDGDAAAAASGPPQCRFEVRAQYHVGDLVTCVRPGSFAATSLMKAPTPSSSTPSPLLLPGIAGPQLVFATAHGGFGVVTPLHAATYLVLRALEASLERTLTPLGGLSHQAFREVLHAGQERGVSYLASKVGCALTRERLRRYESLNTVDGDMVEQFLRLSLHEKRHVCRVTTDVFLHAFAQCVNDSGTFVAPPAHQEQCRQSAPGTTMQPFSQYPKDTIAQAKLFLEKGSLPLPPFAVEALEQLVVNLQRVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXF6</accession>
    <name>A0A088RXF6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_310600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701449.1">
        <property type="nucleotide sequence ID" value="XM_010703147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXF6"/>
    <dbReference type="GeneID" id="22577486"/>
    <dbReference type="KEGG" id="lpan:LPMP_310600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310011200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_310600"/>
    <dbReference type="eggNOG" id="ENOG502RQWE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="263617at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035368">
        <property type="term" value="F:selenocysteine insertion sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040051">
        <property type="entry name" value="SECISBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13284:SF4">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13284">
        <property type="entry name" value="GH01354P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="568" mass="62804" checksum="425FC67929D98705" modified="2014-11-26" version="1">MPLSENALLEQHRPQEQCSTNNKKRRRKNAPPLTSAPTTTQPQQLFSLLPHMANASQPRCTTARNAEKAVRAKIKGKKWNPNAVTTPFNHRARFTKLKRGIHVQRRWALEFLPTPTPQMCACTAAQAERFKASPASLSSLSSTEVWTDNGVNDGDARADVGTRKVCCDSQATVERTVAAMNSLYARLDAAMKSRRYRQAGKLKRCIRAHQLRLRRELQARALQSLLRGDADRSSQALSDTVGAGMQQTHLMVSSSDAALLLSPYRSFYPPSTWLGVGRHPHSAWVDQRTGRYPQICTEEILQAVVRRFMNGDGADRDTLPDPHKALVSAPFSLPLSAALSRSQRAMKSSLFAAAYCTNVLTDMLDDLCFTLLQGLYKEQHDLRKKQPLQFKARQRYVVGFQEVLKCLKAGRVRLVLLATDVEAVEVSVSVLPPPPSQPSVSVSGGYWVPSSSSRPAKKLARKKAFQTLHEAVQLVQQLCGVAGHLARDTVAHLSGHSARAPPLCVSCMSRQRLSYALHAKGSKIGCVAVLQAEKNREALKAVMCYARYLTDAYTTELEATMAAEKQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RY13</accession>
    <name>A0A088RY13_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_320100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO00899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701699.1">
        <property type="nucleotide sequence ID" value="XM_010703397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RY13"/>
    <dbReference type="GeneID" id="22577751"/>
    <dbReference type="KEGG" id="lpan:LPMP_320100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320005900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_320100"/>
    <dbReference type="eggNOG" id="ENOG502S22G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271784at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="34701" checksum="FC136655116DFF37" modified="2014-11-26" version="1">MGYTSDKIVVRTKHDSEEEAHDKNLMERIMQKNQNPFQALVDPLLAKTSYVYHTYLYSSGMMFLMLAFWGAYPSFVRFRHAHVFRYRRTQLSFRRGLFATEHIPKWRKSHLQRIVVPPLPVRELAIVRPAAASSVQSIPSSPSDVPSVVSVTAAADSAVMEGAARDRDLGFDMLEMSATRTSHASFGAGETENSERTLSGELVSINRDFFGPKSHLFSRPIQEDFEMSDLHRRLKTAVATAKAVLVLRENHSTVRSIPEGWEVWWVSEPEARRRRFCKFWLGGLVCARAFQDLMDMPDMPDFVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RY27</accession>
    <name>A0A088RY27_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger protein 2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_321830</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701868.1">
        <property type="nucleotide sequence ID" value="XM_010703566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RY27"/>
    <dbReference type="GeneID" id="22577924"/>
    <dbReference type="KEGG" id="lpan:LPMP_321830"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320023900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_321830"/>
    <dbReference type="eggNOG" id="ENOG502S6HM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2020426at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035329">
        <property type="term" value="P:hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051252">
        <property type="term" value="P:regulation of RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000035">
        <property type="entry name" value="Salvador homolog 1 (Drosophila)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000003">
        <property type="entry name" value="Zinc finger CCCH domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030030">
        <property type="entry name" value="Sav"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47522:SF2">
        <property type="entry name" value="PROTEIN SALVADOR HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47522">
        <property type="entry name" value="SALVADOR FAMILY WW DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="WW" evidence="7">
        <location>
            <begin position="23"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="80"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="80"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIO01068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="127" mass="14330" checksum="BDA68A96F6A0822D" modified="2014-11-26" version="1">MNSYVGGYNTHRRGYAPMAPPPMQMPSGWEMAYTPNGEIYYIDHNTRTTHWQLPAEYSMQPPMCSYRGPQRQRRGIDRSKAKTKMCMNIENGGTCSYGSNCAFAHSSEELSTHPHFNPAADSGSYPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYG9</accession>
    <name>A0A088RYG9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Maf-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_321100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO00996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701796.1">
        <property type="nucleotide sequence ID" value="XM_010703494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYG9"/>
    <dbReference type="GeneID" id="22577851"/>
    <dbReference type="KEGG" id="lpan:LPMP_321100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320016300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_321100"/>
    <dbReference type="eggNOG" id="KOG1509">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10267058at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213:SF4">
        <property type="entry name" value="7-METHYL-GTP PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="BIFUNCTIONAL DTTP/UTP PYROPHOSPHATASE/METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839148" description="Maf-like protein" evidence="2">
        <location>
            <begin position="30"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="30313" checksum="1A067355DB3643A2" modified="2014-11-26" version="1">MCRCELACFFFRCFFFFASLPTLHNFSRCHQEGREGCTTRRVRTTTQAHTSPGVQYRPMERMEKPIMVIGTSAPRRREIAQRHFGAAYDLVYLSPAIDEKQIRDSDPFALTSAIAQAKMEELRAKVARDTALAHRIAHRPGSVAVTFDQVVNYHGEIREKPESQEQAVAFIKSYSNDNLATVMTTVLYHFGTGKQASMPNTTLTFYGEISDETVAHVVERGTCLHTAGGFVVEDADMKRCEVKIDPGTEEEVCGFCENSVRALLADVQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYN2</accession>
    <name>A0A088RYN2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_321660</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701851.1">
        <property type="nucleotide sequence ID" value="XM_010703549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYN2"/>
    <dbReference type="GeneID" id="22577907"/>
    <dbReference type="KEGG" id="lpan:LPMP_321660"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320022200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_321660"/>
    <dbReference type="eggNOG" id="KOG0703">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08204">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000009">
        <property type="entry name" value="stromal membrane-associated protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051718">
        <property type="entry name" value="ARF_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705:SF1">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="17"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="385"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="462"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="680"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="391"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="688"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO01051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="736" mass="79687" checksum="AED76E7BBB668BDA" modified="2014-11-26" version="1">MASILRQSKEVQDQHKRQLLALLKHPDNAECMDCCARNPTWASVNLGIFICIRCSGLHRQLGVHITKVKSCTMDLWEPEQIAFMSEMGNQRAKRAFEATIPASYVKPAERDASVKVMKWIRLKYVQRRYYRPLPLPAADANAEGAVDLSKYAKPEKAPKAGEATERVKAVTPTKAVVKTVPLTFNPVPSTPAATHSHHPVLGVSTVLSTTLNASCAPTEKMAAILDWLCSTMPYVMAEDFENLSTLLVPPVPAAKNSALNNGSSPAAVMLKTPSASTPVTTIAPTTAVEQDAASLVLTSAPREAGKSHVMAMGCSTAKQRQLTPPIRGLGAVLNDATVPAETQESASGHHEKVQTATSSLHLDPIPDTKLVVRADSVVETAPNGEATAAVRPHRHRRKRRSLKDTLQRSHLPSALPFPLSSIPQALTVLPFLSAPSPPMETARVEPSCSSRQDVERIRNAAHHGGKQHGYGSEPLPEPPRQLPTQQPVLRPAHGPAGTFVLSDRHETCASTPVATLLLPSQEPMMPITSTEPALAGSTLVEQSTHVIPSVKDLTCTQGVASMTPSFASGQSAVAAAVALTPMQPPFTKPTLAGALHSQDDAWQTDRLVLFSGKSYGLCSSQRVLFSPPAADEEWRVPQPKIRSPNFSFSEELRPRQPAFEKWAKRVPNTSITRIRGSLLSPIAEDGSTAPQTPSAQLDQPHTDDTPTLSGVLQTQRHLEERLRVLKEQFRQRSDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZ41</accession>
    <name>A0A088RZ41_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_323770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702059.1">
        <property type="nucleotide sequence ID" value="XM_010703757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZ41"/>
    <dbReference type="GeneID" id="22578118"/>
    <dbReference type="KEGG" id="lpan:LPMP_323770"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320044700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_323770"/>
    <dbReference type="eggNOG" id="ENOG502S2TP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264619at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="113"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="284" mass="30733" checksum="D7C01BB0C306A64B" modified="2014-11-26" version="1">MKAVLERRAEALLLATQEEHRLLEAQLEKSRAAREASTRVSHGKSRGAPATAPAAATSSAGPQREDSAAMWIENASCLSIGSTTATSPDRHPSPSAVSPSASPPRVILPSAATHKEGVLLHLVRSSSLFGGVSASFVPHYIVVSDSAGISWYTSEAEYRQNPRRPLGHADFWIETYNSRGSRFKKAAVCWPLILPDDCPEARDPSKTYFAVDYYTPNGGQEQLVLAASSPAERDAWVRLLTKYIDLYLAPRTESEELQHIPRGAEVPLHRSGVIEGEAPGGNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZ46</accession>
    <name>A0A088RZ46_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_331360</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. MFSD6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702228.1">
        <property type="nucleotide sequence ID" value="XM_010703926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZ46"/>
    <dbReference type="GeneID" id="22578289"/>
    <dbReference type="KEGG" id="lpan:LPMP_331360"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330018800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_331360"/>
    <dbReference type="eggNOG" id="KOG3762">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="261787at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051717">
        <property type="entry name" value="MFS_MFSD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172:SF41">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="477"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="117"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="529"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIO01428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="589" mass="63725" checksum="11B8639F609C4A40" modified="2014-11-26" version="1">MPPPSLLRGRCGGSESGSDSLSVDTCGSCASVTLAMVEPTMTDGSLLISAPNSPSRSCVEADIHSAVFSTNTSFAGGNSKTAVSATATAVSAGPGRSTEAADPSDFTSGAPATAAATTVVVNVMPAIIGYFSSFFGSGICAFYSRIFQAKGFSPYEIGILISANPLLNMTLLPVLSYLADKFRCQTAMLFVCIVIATVSMFGYTISDRRVPTISWFLVMTASRVSLSPLLDQRILMMFPKQERSNAWSYVRSYAAYGWGIGSFVASLVFLYTVSWVAVTMQYLLGQIGLAYSMVVIKPYERTERVPVHFVEVLKVLRTNKRLMLFLFSSTMMGAGYSFIDNFLFLFLGELGGSEVLMGFTVVLTVSTEIPLFQMSARLHQTLTERQMMAIAMSVWSFRVVCYTILTNAWMVLLIEPLHGVTFAFMWLPSMQIVSRAFPPKLSSSATGLLFTLTSGVGPMIGNLIAGTLYASVGPRKMFLSAAVVMMTSLLLYQVLDSILERRGLPVLYEPDAGQAVATDLAVMEIMDHATTQQPRKETTSASAVEDENNGNRRRGATRTISTPRMQMEGPNGGRLKGQQNDVAENDLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZJ0</accession>
    <name>A0A088RZJ0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA replication licensing factor MCM3</fullName>
            <ecNumber evidence="11">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LPMP_332820</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="11"/>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702373.1">
        <property type="nucleotide sequence ID" value="XM_010704071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZJ0"/>
    <dbReference type="GeneID" id="22578435"/>
    <dbReference type="KEGG" id="lpan:LPMP_332820"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330036100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_332820"/>
    <dbReference type="eggNOG" id="KOG0479">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1882346at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000027">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008046">
        <property type="entry name" value="Mcm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF46">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01659">
        <property type="entry name" value="MCMPROTEIN3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="324"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="551"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="556"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIO01573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="876" mass="95367" checksum="BD4F0F0588FE5876" modified="2014-11-26" version="1">MFINRTLTEEQTVIRRHFTDFFESERYEEKYHDRIQAMIMDGKARLLLDIGDLLDYVPISAGGDGGDGMGNGGAGSELGFSLGANIIRQPGKYIPLLELALHDVVLRQQPEYLKVDYRSRVVHTGFEGPVGRVLSPRELYARHLNTMVALEGIVTRQSTNRPRVLETVHYCFETNKFTKKEFRDQLTPMIDSSHLPTVNVMPKTDIEGHTLRTELGLSTFMDSQCAVLQEAPERAPTGQLPRNVEVRFDDDLVDAVKPGDRVLLVGVYMPYTTSDSKSFQSIVLVNHVVSTQAFTFLYRPIASVEDRLTRFAQKCFEQLGPSGVLETLSRAVAPTIYGMTAAKQAILLMMAGGVERKSHNSHVRGDINILLVGEPSTAKSQLLRFVLGIAPLALSTTGKGSSGVGLTAAVATDSYTGERSLSAGAMVLADRGILCIDEFDKMGSQDRVAMHEAMEQQTVTIAKAGIHASLNARCSVLAAANPIYGFYSVQHRLAFNVGLPESLLSRFDLTFIILDQHTSDYNRRIGYHILRNHMTAEAVRYDEVESRTVVDSIETGGDRGDSEAERGSGDGRRGGRAVGGEDGSSGESRLDLRMTTNSTGESVVSSDFLRAFLQLAKRGSPLLTEASRDLVCQHYVQLRAEQQDGGRDGFFITPRTLDAIVRLSTAHAKLRLSPTVEEPDVMAAITLLRSSVNAATTATQQRNDDNQHSLSEVAAGAAGPLQTPGQKRPAAAVEVVTAQDGAVKSYAHLGSGTREYADDKASGIDSYQRLRTEGARGDDSGGSSGEAGAILLEVPPAVTAGAAAAIDVHLNRRVIEVLRQLQREQRDGASLDELHERLGMHTISAESLKRSVMQLQGDAFIFESTEDGGNNTIQFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S075</accession>
    <name>A0A088S075_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_341610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702588.1">
        <property type="nucleotide sequence ID" value="XM_010704286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S075"/>
    <dbReference type="GeneID" id="22578666"/>
    <dbReference type="KEGG" id="lpan:LPMP_341610"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340022000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_341610"/>
    <dbReference type="eggNOG" id="ENOG502S0BI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="238257at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="15748" checksum="101080CDF34D049B" modified="2014-11-26" version="1">MLRTRLYLAPMLSKATRLQLGNIKTEYGTVSTAAGSVEKWGFLFGGNMYPIVSLSFGIFTVCATMAVAATYQQYRDMVIVTEHISYEDVKDRCLTPMPGWVRLRSFSMATPQGPATFRDPTPLDWLPFELKLGYVKQASY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0N6</accession>
    <name>A0A088S0N6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_322110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701895.1">
        <property type="nucleotide sequence ID" value="XM_010703593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0N6"/>
    <dbReference type="GeneID" id="22577952"/>
    <dbReference type="KEGG" id="lpan:LPMP_322110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320026700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_322110"/>
    <dbReference type="eggNOG" id="ENOG502SFM1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="252091at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="110" mass="12399" checksum="70D8610AF90C36B3" modified="2014-11-26" version="1">MADQAPPGVNMPKKRDPRLRQVQAPPQQKFFDSADYEVRKQQHQDQHQHAGQQQSHHSTHSQMAPNGIPHREPADVPRPGALDDGAPREKIPPPPLSEGYVVQRARRALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0W7</accession>
    <name>A0A088S0W7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_322600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701945.1">
        <property type="nucleotide sequence ID" value="XM_010703643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0W7"/>
    <dbReference type="GeneID" id="22578001"/>
    <dbReference type="KEGG" id="lpan:LPMP_322600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320032100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_322600"/>
    <dbReference type="eggNOG" id="ENOG502SEMK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267512at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="621"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="751"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="795"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="582"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="757"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="795"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="810"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1007" mass="108610" checksum="6C27FF6C31EB0633" modified="2014-11-26" version="1">MPPNSLSQPQKPRHITASTHTLAARLTHNTVERVTVGNTPLHMLHLCDVQCVAPLFASCVSLTAMTIHLKYMASSTALELLLCAAATSPTLKHISVMGGVTLMEASAMASGIAAFTWDKRVGGQRVSFADATPESPLPRTVRRVPSAREGRHFASRGHGEREDACRRRCLNSDRSAAFSPYAGTPPPTHLRRQPCTNNERGALQPTSTSSRSTQSRLRAGAAMWPVPYAVSPVVALVSHRTSPALSPGFLRTPPHASLLSAHHIEGGICLTLELHRLSEATATLLLDGLRRAHRIISAEVRLCVATAEARHAGQRLAQEAKKVAAHHRQRRLLLMTPPTPKSCLLQARAKEQNVSAFHRRSPYTSGLRVSPRAGLCTPSSPPQRPLASLWPATPVEPDAGCNGHGRRRTLLSVEALGSRQRTARRHEQRLTPRSAAAGGMFPREDSGTPVQPHTPLTPLPSSMAGGGATMRAQRPVLSANERVTVQPSQPDALRRRGRHASPPPVRVCANTLSRPVSPNGHLKQVGRLYSPPRWASRAQPLTNGPAPPPLPLSKVALCPTPQSASTRNTLSPTGWRLKHHASSTSSWSSWSSRSSSPLPRPPQPSPRRATESFAHLVVRKQATPDEEREHAKRLAQRAPPDAVSAFLNRRGLCRLSPFSARQPHSPPSYSNLLCSPRYCLRRGSDGLGDEAGQRGIPPPQTPPHSFSSRCSCFVCHSQLPRSPGTNTRQAPRPATPANLEDAILALAASVARAPRPRSSPPFPCSPPSAPSSLASPPPPLPVVVAACSSRQPHKHDTISAREGRGAGDVTPTTHSAATSVNGITPPRRQSGGERENDNATAFHKAAISASSSSSRTSRSIHTATDSVHRSLNMDLGEGDHAGVRHSSACGRMEPAVTRCEGSHLQVSHTQLPSSLPLQTPEHQQQQHGEEVGYVVYPNSVAFLRARVKEINRHVVWHQIQSAKAVEAHSRHLAELEVTFSDRVTEGLTDILMVLTDMEHGSRIDGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0W8</accession>
    <name>A0A088S0W8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Right handed beta helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_010250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009370">
        <property type="protein sequence ID" value="AIN95126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696668.1">
        <property type="nucleotide sequence ID" value="XM_010698366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0W8"/>
    <dbReference type="GeneID" id="22571754"/>
    <dbReference type="KEGG" id="lpan:LPMP_010250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_010006900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_010250"/>
    <dbReference type="eggNOG" id="ENOG502S0K6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="164285at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Right handed beta helix" evidence="2">
        <location>
            <begin position="668"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="449"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="478"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="830" mass="86590" checksum="12C029559581E65F" modified="2014-11-26" version="1">MDVREELVQLYRTYNPRRLKDIDAILEQFKGRERAMVTALREKYTRGGASADSSFTGASAAPLAEVPSRQTVTREVAAAPPPPTAAAAVGEAPLSAPVPPPPSSTAAHLSFADRSTGEAALSTFIPSPCAGSAAIGPATATAAGTAPAERHREMARLIDQMCSVDVERLAGRVAMLSASAPSPSLRTPRLRWRTQSREALVLQVDGEGNAGRYSSSSSSNRELTELLRHTAVFLNFFSQCARRFLLLAEEEWGRLAGSALTASDGAASSWVPPRMEARRTAVEVPQRSPHQGHLSTRGSKDNAEPMRSGVDGPPHDNGNHERDRWCGSSSSNNGGNDENAAPGIGTHPLSSTRARIQPNAAIVSPPEHYAGAPPTPSAVAAPVHSCDVNQAHATVSSSRRRSSCVRGIRQPSLFSSSASPPRASTGSPPLPATERGGDRVAGSSSPTYRTTTVSPLTSSTSRRSGHSPRTPSPPSPPRHSGGEATSGASAAAVTVRTHADQHSPSLPLDDSPAATPPRPLDSPPTHGGALILRPPPALTPLARRRVHTWTPSSQLNRYAAACAALQSGDCVVLQPGVYYEELVLDNCGHVELASAYPGAAVVLRPSSKLAPALRIRGARSQVELKGVVLVQGEGIEAKDTQMVAAASAALSSTFSTAPALPLLSVSDGAVLQATACHFYGGAGGGVIIAGPHTHATLDLCLISLCSFAGIYVHNGASVEVRQSKVKKSEAGLRALEASFYVSESTLEENKTDGIVVYKGSMGVLEGSSLLNNGGNGLFLEGGSGEEVRVIGSTIELNAFYGVQRSRSSTLHIQSSYIRDNGLLPISEEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0X2</accession>
    <name>A0A088S0X2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_344310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702853.1">
        <property type="nucleotide sequence ID" value="XM_010704551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0X2"/>
    <dbReference type="GeneID" id="22578936"/>
    <dbReference type="KEGG" id="lpan:LPMP_344310"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340050600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_344310"/>
    <dbReference type="eggNOG" id="ENOG502SKN1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="59941at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="2">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO02053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="264" mass="28840" checksum="25521E3E2D296B29" modified="2014-11-26" version="1">MYHGVCTPPQQPSMTSIVYVQTTQPSPVAYYAAEPIIDQQSIQALQQHQVSLVYPGTAAPQPIHAPHQPTIIPETYASEATPFYAYQPTLKEARCNTGSLVCLVPTVAASSSPQLSMLMQSLSSNSPSFHSDLSLRTQETRAAPQMMQQMLTTEYVQPAMEAHGSLSQSVIDPSTKSPLLSSSEVCRHYINGRCNRRKCRFLHPDLRSPIMTSHVMYIAPDAASIISNQSVPQVSPLTPYPSLSTPSLSAFHVPALTSWETCPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0Z7</accession>
    <name>A0A088S0Z7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="9">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_323100</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="9"/>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701995.1">
        <property type="nucleotide sequence ID" value="XM_010703693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0Z7"/>
    <dbReference type="GeneID" id="22578051"/>
    <dbReference type="KEGG" id="lpan:LPMP_323100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320037400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_323100"/>
    <dbReference type="eggNOG" id="KOG0888">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2162449at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04413">
        <property type="entry name" value="NDPk_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000002">
        <property type="entry name" value="Nucleoside diphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001908">
        <property type="entry name" value="PRK00668.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11349">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="11">
        <location>
            <begin position="91"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="7">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIO01195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="239" mass="26698" checksum="9F3BF649EAFC1941" modified="2014-11-26" version="1">MFHQLLSSSLRVPQHTAKPLYGISVHMDEMGRTTKALLVARHTLITPFVFLFLVSLLLTYASPASICPAHSQRFNSHFYDYHHHPNKTMSSERTFIAIKPDGVQRGLVGEIISRFEHKGFKLVALKMLQPTTEQAQGHYKDLASKPFFEGLVKYFSSGPIVCMVWEGKNVVKSGRVLLGATNPADSQPGTIRGDYAVDVGRNVCHGSDSVESAQREVAFWFKAEEIASWTSHSACQIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S114</accession>
    <name>A0A088S114_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Meiotic recombination protein DMC1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">DMC1</name>
        <name evidence="12" type="ORF">LPMP_344740</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RecA family. DMC1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702893.1">
        <property type="nucleotide sequence ID" value="XM_010704591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S114"/>
    <dbReference type="GeneID" id="22578979"/>
    <dbReference type="KEGG" id="lpan:LPMP_344740"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340055200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_344740"/>
    <dbReference type="eggNOG" id="KOG1434">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251254at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19514">
        <property type="entry name" value="DMC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000075">
        <property type="entry name" value="Meiotic recombination protein DMC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000239">
        <property type="entry name" value="Meiotic recombination protein DMC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011940">
        <property type="entry name" value="Dmc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003301">
        <property type="entry name" value="PRK04301.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02238">
        <property type="entry name" value="recomb_DMC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF30">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN DMC1_LIM15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="Rad51 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0469">Meiosis</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="10">
        <location>
            <begin position="117"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="RecA family profile 2" evidence="11">
        <location>
            <begin position="296"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIO02093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="359" mass="38969" checksum="070B2956F34E827E" modified="2014-11-26" version="1">MQQQQHSAHFAEERALDRGAAFDEPQQLPNSVTGEAAGQPLLEVERLAEHGIGAADITKLKQAGIFTVPGVQMQCRKDLIQIKGLSDAKVDKIIEAARRVSDVGFITGSIYLQQRSTILRISTGSTALDQLLGGGGIESRSITEAFGEFRTGKTQIGHTLCVTSQLPLEMGGGNGKVVYVDTEGTFRPERIRPIAERFGLDPNSVLDNILVARAYTHEHQAHLLSMVAAKMAEDQFSLLVVDSITALFRVDFSGRGELAERQQKLAKMLSQLMKIAEEFNVAVYITNQVVSDPGGASMFVADPKKPVGGHIIAHASTTRLSLRKGRGDQRVCKIFDSPSLPELECVYSISEQGITDAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S132</accession>
    <name>A0A088S132_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">VLRF1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_344890</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The VLRF1 domain mediates binding to the 60S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ANKZF1/VMS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702908.1">
        <property type="nucleotide sequence ID" value="XM_010704606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S132"/>
    <dbReference type="GeneID" id="22578994"/>
    <dbReference type="KEGG" id="lpan:LPMP_344890"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340056800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_344890"/>
    <dbReference type="eggNOG" id="KOG2505">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="429841at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047139">
        <property type="entry name" value="ANKZ1/VMS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041175">
        <property type="entry name" value="VLRF1/Vms1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16036">
        <property type="entry name" value="ANKYRIN REPEAT AND ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16036:SF2">
        <property type="entry name" value="TRNA ENDONUCLEASE ANKZF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18826">
        <property type="entry name" value="bVLRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52044">
        <property type="entry name" value="VLRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VLRF1" evidence="12">
        <location>
            <begin position="351"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="109"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIO02108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="516" mass="56690" checksum="D8C0EAAF3EE1E2A9" modified="2014-11-26" version="1">MLLSAVEKKITAVLQSLRDTPRTPYEMENLYQLNCERIATARAALADMSGDYIDRLRARCMEAEKQVQAKRAAGVVDTATADTAFSLDFAIEETEGQNDAEIQSAMEAVAHGSRRPKKSNENGKLKKQKDGEEGHKKRGKRTPADEPFALSHLAGCGSGEDNAVVTATSSCLTRWVVLSRNNNLSSSEVPSALSSSGRGRCEAVPNTSLARAFFTEEMSWDGVLCLCAVELYRCVVIALTYGEPQLSWAECEKRVKSQEAVASKVGAITEECFSSHTAKCEDLRSPNKFSDGDGEDTESDSPSAVEDMTLSEQLIAEYHQAQQAEEEHDADTLALPRDVSERFQQRLRGFTEAMWVILLCHGGYFAGGVFAGGTCVAHKAFQRYVVRKKQGGKQSSNAKDAGSYNSVGSQIRTAQEVKWRVDVRDILVDWTPYIQAASFILYAAPGPQNRAVLTDFSLLPAMASVGGRKCDSPIQLKDPRVSRVPLTTHRPTFEEVRRIYGVCSHCSLLYVREEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1B5</accession>
    <name>A0A088S1B5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Leucine carboxyl methyltransferase 1</fullName>
            <ecNumber evidence="6">2.1.1.233</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_350080</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine = [phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:48544"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="2.1.1.233"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the methyltransferase superfamily. LCMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.233" evidence="6"/>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702948.1">
        <property type="nucleotide sequence ID" value="XM_010704646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1B5"/>
    <dbReference type="GeneID" id="22579037"/>
    <dbReference type="KEGG" id="lpan:LPMP_350080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350005700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_350080"/>
    <dbReference type="eggNOG" id="KOG2918">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="203237at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018423">
        <property type="term" value="F:protein C-terminal leucine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016651">
        <property type="entry name" value="LCMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600:SF21">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016305">
        <property type="entry name" value="LCM_mtfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 8" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="133"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016305-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO02148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="296" mass="33700" checksum="40B2D05857355279" modified="2014-11-26" version="1">MALIQTAHDACSRKVHCVRKGYLNDPFVSFFEKDHTIVNSPLMNRGTWLRTTAFENCVRGFATTAGEPIQVINFGAGMDTLFFRLKHSDPQIPVHKFVELDFAELVAEKEGIIKRHTELHSLVGSQYELVSCDLHDAKGVAEMLKEHLRGGTPTIMIAEMVFVYIEGSVTTNLLRTIMSDVIEENTKAMLVIYDAIQPFDRFGKVMVENLQHFGADFRGICDFPTPEAHAQRCTELGFKTVKSVTMKNLYLSVPRQIQIRLNKLEMIDDWEEWNLMHEHYCFVVASTDSAPLPKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1H0</accession>
    <name>A0A088S1H0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FPL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_344400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702861.1">
        <property type="nucleotide sequence ID" value="XM_010704559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1H0"/>
    <dbReference type="GeneID" id="22578945"/>
    <dbReference type="KEGG" id="lpan:LPMP_344400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340051900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_344400"/>
    <dbReference type="eggNOG" id="KOG2219">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="294052at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901096">
        <property type="term" value="P:regulation of autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039272">
        <property type="entry name" value="CLEC16A/TT9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019155">
        <property type="entry name" value="CLEC16A/TT9_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21481">
        <property type="entry name" value="PROTEIN CLEC16A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21481:SF0">
        <property type="entry name" value="PROTEIN CLEC16A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09758">
        <property type="entry name" value="FPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FPL" evidence="3">
        <location>
            <begin position="54"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="927"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="930"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO02061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="959" mass="105525" checksum="38E78F46520DF3AC" modified="2014-11-26" version="1">MEKIKEAFGRVDKFSLENANRLCMEVERIEETLLSDAGSAEPKMKLIDASLQQIRELTEVLIWMDSCHDEWFEQVMEHDVMDTLERLATNALIPSSVKLQSLQSVTVMLQNLSRDSSLFYVCSNNHINRMVAAEFDIQDDEFVSLYVSFLKSLALRCTPDTVQFFFDVQNGAFPLWNRAVRLLDSADVMVRTATKQIIVTIAQLQDAAVSAFAETSISDVFQSVLGFVEAQIVRLAASVPSWSTLHESVGFPKAYGDPNVGKFPFSADPAATLPPPPARSPLVVDTRALQIQLDDVEDELLYLNDLCRTPVPNAGAQAAAVLQRALLPHFRSTIQSEVDSASSASTSSGRNVAHATHSIPGARFSGSCTPASVVLAFLSYWSQVNTDARVAAALVDFFVKPLNSSSGTSCFTVASMVLESTRVDLHESVVVVCRHALSRTGTQSTLLVSFPPSLRFPSSLGQFFYANTPYQQTGTVLMSGPCSTTLPSKEKFVQKVWPSPPTATTNPFVLLVPHVVAALYTQLKYFQATRLSCVTASLSLLLDMISSAAPGKPEWASVYLELMKLVQRLLLNCVKQYASAIQKTLHAQKTADADMPHSHISLRDTLESTNEEAALPIRDPYTPMFLKLKEAAIWMEAAEQARLPLLETAAQRPSKRDLYLFFPSFPLLFTDESRLILNTWPPLLLTVCRQPGVAAQWAVAYHVAQESVVRALDYPNRAPVSDAECELNLYLTLLLMRRAFVGHAHRSGVDVLQMTLRQLAPQHRQSMYFTLTSTATALSVRCEITSEWHLDSQAPSIAPPGTPVCMVLPSAAAGREGRELLFLDIPISVPERVRSQELLAGKHKRRVLCSLDLAFVGINIHPRYPFKVVLSYQLSGHVMLLHLVTNGTAAAQMMVTGVEKAANECRQRGASFCFGLMNYRSALLGDESEQDRPAGKEGDHFLSGSARGEAADVRASSHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1M2</accession>
    <name>A0A088S1M2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_040570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="AIN95381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703703.1">
        <property type="nucleotide sequence ID" value="XM_010705401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1M2"/>
    <dbReference type="GeneID" id="22572016"/>
    <dbReference type="KEGG" id="lpan:LPMP_040570"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040012400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_040570"/>
    <dbReference type="eggNOG" id="ENOG502SAWQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273835at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009548">
        <property type="entry name" value="Prkrip1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06658">
        <property type="entry name" value="DUF1168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="164" mass="17987" checksum="F7F6945A90E18AE4" modified="2014-11-26" version="1">MPSSSSSGNNHVGSATPPPLTPEEKAARDVRLQREHESYIRGIATMRSLPRLRSTIAGAGGKTNTITRIAEEREEVRQQHLRAAAAAAADLLLRRQAHQEKVKKLESSQAKKRNRRAAKKLKKKQRLEEELRNRLDSDDSASSSSSSSSSKPSSSDSDSDGEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2I2</accession>
    <name>A0A088S2I2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_353320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703269.1">
        <property type="nucleotide sequence ID" value="XM_010704967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2I2"/>
    <dbReference type="GeneID" id="22579361"/>
    <dbReference type="KEGG" id="lpan:LPMP_353320"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350041000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_353320"/>
    <dbReference type="eggNOG" id="ENOG502SJV2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="278656at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="858"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO02469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="884" mass="94624" checksum="1B6AB1D8D121936B" modified="2014-11-26" version="1">MENVQASPCERDDVQTTAATKAANNTGVRRRRMGEVYPIMKNTIYSDEECDVVVLNSWDCGTLFIRYLNGLFQYFVRNPKPMGLILTTAIILLFFKYSQQVVVKAVNAAVRAHPGLEPTDTLRSAVMSFTEELRGLEQVVQTIGWAYMRNSVIGYDISTSADTTFFSLVSSFQSSFTANVKTYVVYTLPRAASTGFTSAHWGQIGCASEDNNSSVCFYVDENGTVRPWNTVTNASDGGPSMSGVYIEGCMPDLLSVATTATKGSTLAASGVWTRASMTCSIFSQKPVRTVTYLLPIAFNAEGYATAMAGIDVSVGLLINSVKVTATPNIELVVVDNRYSASEGGQFVYDSFNESIFWSTSYGVLNAPVSRVRDLAEAIWRENDGTLAVNGSFYLNGLIYQSLTMMSHWTLIASSPLALSVAEVAATLSAFVKESKGIAAAVSGLYHDCEIAATKQQNSITVESFGQIEFAFGIQLHSLYTPYVLAGAEEGSSSSSCASSNATAKNTAPQASLHSSFSSAAAAFSGAGATNNSLHEFSTGSGSVNHVSSSSSAPAQPLVPSSTANDAIAIPVASTDSSGKTMEETVALPATTGRRPVNMFGVDAAWSASGGSAAAATRHKWGVCGCTYSSSTQMTCFYTDSNQLETFFEGSVFSDSAKDKIETRKLSTSLHGTFTKQYIEGNTATAGFWTKPYLRTDTTGNTSVIVSYVYPSVYDSNGYVTRATVLDTTAGWMASTLKVNQHSGTTALYLIDRRDEGTFLASSTAAHAVNAMYTALSTPDPEFDRIASAVYSTAGNTWERSLSLHMGSTLVNYQVLEGQWGVIEVMPGDVALQRYLPTPAVTGATDALRLLPHEETVQLFLYVGSILLVFFLNLLILGCSRLGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3B8</accession>
    <name>A0A088S3B8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_090700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN95986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704308.1">
        <property type="nucleotide sequence ID" value="XM_010706006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3B8"/>
    <dbReference type="GeneID" id="22572640"/>
    <dbReference type="KEGG" id="lpan:LPMP_090700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090012500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_090700"/>
    <dbReference type="eggNOG" id="ENOG502SFBF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266249at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="453" mass="49758" checksum="DDA4DEB8198E36F3" modified="2014-11-26" version="1">MMPAKTATAPTDDLFSGKSRELVDDIKNSLDRIEKLLNCGQQLLYGDGAADGEEASVSPDEDPADVSVVAISALRHFNPSYASYHSSPQRRRGSSCGLGSGGESVAHQQLASRSQHSSENASHRLSGEGSHQHSLKNSSKECSRYGRSRADQRLMGSNRPLLRSKRNEVSPSLRGRQIRSERGRMRNLEEGVDPSDTPQNITIAALKERIRRELEEYRRSGPLMHRIELHQRLQRAVIAKRALSKNGASSPSGAATAVSRPSACVAAASVKSGSHAAPESRQVVKRANTTSTRRTLQNLQEQRPLWEHSYRNTAMQQPKWDHRAQQRHVENGRSVEKSHPPTVASPAPNTYSPHYHPLKMSTGSHSSSRDLSSNQTSGSSYAPRQHVCPVQNHQRDSPSAEGTSKSSMTTSQLTTERPARVAVPQRPSVTNSSPDNMEEHSTLSPTWHHLISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3D4</accession>
    <name>A0A088S3D4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras family protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_090850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN96001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704323.1">
        <property type="nucleotide sequence ID" value="XM_010706021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3D4"/>
    <dbReference type="GeneID" id="22572655"/>
    <dbReference type="KEGG" id="lpan:LPMP_090850"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090014000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_090850"/>
    <dbReference type="eggNOG" id="KOG0098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="326" mass="34333" checksum="CB4EBA5D4C4CE24A" modified="2014-11-26" version="1">MLKRQRIPSLPFSLLNKTSLRHPLTVEAPFHVHPRMPFLLVMPAASAAPPHLPASLDYPRIKLLAIGDVGVGKSCLIKRYCEGRFVTKYIPTIGIDFGIRKVEVDKAAVLQQRSSGPSSSSSSSAAAAQCGINSCGGGASSAIPTDVRVNFWDGSGDDDYREIRNEFYEAAQGVLLMYDARNAQSFSALQSWWEELCAYCQGMPAAESGGGGDGRGPASPGNAVAAGAGGKRMSVLNAVTSSTAAGKAVGRTDGKAPVVVLCANKVDDTAVPGAAAPRPRAVSEEQGRAWAREHGCAAYYETSASTGKNVKEAIEDLVVRMVAKFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S4J8</accession>
    <name>A0A088S4J8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dynein regulatory complex protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_354270</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703360.1">
        <property type="nucleotide sequence ID" value="XM_010705058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S4J8"/>
    <dbReference type="GeneID" id="22579455"/>
    <dbReference type="KEGG" id="lpan:LPMP_354270"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350050800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_354270"/>
    <dbReference type="eggNOG" id="ENOG502QTXW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10254713at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044782">
        <property type="term" value="P:cilium organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042618">
        <property type="entry name" value="IQCG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14871">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14871:SF1">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="365"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="501"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="598"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="441"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="512"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO02560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="664" mass="72187" checksum="2E33B8C0E1CAFE34" modified="2014-11-26" version="1">MPMMSADESHRASAAAKKPAAAPTFSPFPPRPARGATASAMAKSNMPSSSAASGVAAAAAPSKETPSKAMDLDPTTASLECVLQIGQPTFSTQLDFIKVNRAVASLERAVERLELLSLLDATGPTPATEGNHKNANGAVTASNATAVTSATTAIFHPHNSSRGPAVLTGISHDASVATAQKVAEVLAATQEQRGCGRASVLKLLAEQRVLERRYGELLTQAQPTVSLYPGEPQLCYQCFAQAGDPAQATLQRELALVSNRLRETNRLLCTQLQDNPQDRDNWAKVCNERQELTALLRELAEELTVGYKEAFQQRQGRQQQQQANVVLDGGLQRSSTPGGIMEGVRFSCATSNGDFLSLNSNVTSAPGLARNDSRQSSTIGGGPISTESGSRTSPFHKCFGGTLQRHRTSRTTQQGPRIPLTSSYQQFAVKILQEEASQRWADDMLAKERALNQNVKQLQADLERERELKDKEVAERLAHISTLKLELRKLKASLQQRSEAAKASGEAATENLQREGAAEVRGVRQATQHNEQLLTISATAHDTFSSYLRERTAAMDTLASEWEAKTLRELKKKEAAKIDAEGSRQACAQRLTDLQHERDVQQELKEQRDSAQRAEEDDRRRSEEQRDAEYAAASVLEAALKAMMTRQALSKLQKGIKKKKKASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S4X0</accession>
    <name>A0A088S4X0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_131230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697204.1">
        <property type="nucleotide sequence ID" value="XM_010698902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S4X0"/>
    <dbReference type="GeneID" id="22573233"/>
    <dbReference type="KEGG" id="lpan:LPMP_131230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130017100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_131230"/>
    <dbReference type="eggNOG" id="ENOG502RGSD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21128at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN96551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="837" mass="91284" checksum="E2301B3E801AEC77" modified="2014-11-26" version="1">MDCVNHVTSDADILPCKSDVILSKTSSANFTAGTKPILASHRRLLCMNVKQTNMLRVLNRHGKHNDTTIKVAAVANLVSTEKITGHPTLFYAVGGKDLAIICPTTQANGDISVSLVESKLDEEGYASTAGETQRLYVLGQQNVMEVEESTGLIKSKIPLTPKTTVRYPVIDYHQAAQLLLVPAKSTHLDLISTRTRKSVLGRVWEPHEDTAPTFACFFQHHAFSEESGKELLVVTAAQGNREIRFWAYQSDTQKFALKQQLNLSYKDELREEYDISITADEEYITLCSRTRPYAVVIETHHTLFKAYRMTSWRMAGPALCSTTSVGKVTESAQSKSVSYELFITIRTETGFVQSMPNSSRLAGASNLSVARGDSVANWFPSLATGGAGAGRDVSSASAGSGAAGAALTPITAVSSSLTGEIKTSSLSETAVASIVRSQAQKFCEQVKVIDADLVDMQKSASDTMRLLQDSRYRTEAQNSGRTFAIRNRARLEKNSTTAASTATTKPHATPASVDTAGAVDSEYGVLTTGERELILSIRNFVQEVQGGSAAAASAALKALLGKQLRLSVERTANEASKLEIPAHVTGDFNSLQSVQEYRRVVNASITRIGATTKRFQELNRTTLEASSAQTATCLAQVEAFRQKLSSSLRSMNGEMKELKVALSQCQLSCKAAEGAATPPSPDAILARAVEQAKEGDWKGALTTILASNDIGILLTFLENELCREKQAVLTSPKTLTLPLFLSLCLQLTFEMPLQSGTVPLRLQLLSDFYVEWDDWLRTIRLQAQKDAQQAAVYDIVKRELSTVLEALEGIPREQLDRKSRNKERLVHKLISQLLMDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S6A0</accession>
    <name>A0A088S6A0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_170480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697739.1">
        <property type="nucleotide sequence ID" value="XM_010699437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S6A0"/>
    <dbReference type="GeneID" id="22573791"/>
    <dbReference type="KEGG" id="lpan:LPMP_170480"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170010300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_170480"/>
    <dbReference type="eggNOG" id="ENOG502SKUX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264689at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="670"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="836"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="401"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="681"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="908" mass="93095" checksum="A0830610F1DABAB6" modified="2014-11-26" version="1">MGCAGSKKRALRLREGKADEPDTQQSAVRTRRRVGKPVSLNSAACSSQICTEEGGSSDDKALSMKPHYGHRFAHGVLELSAVKLGLSPLPPDAATAASGDGTPRKPLATSSPDLSQPSPSAAPRPMQLTSSRTGVKDGVFAGKASATDEACHCNERSSLSPWTVDDTLPFAAPHSTVPPGLLCSSSPPPLRLFSPVACASDLADQPSAASLQSPSDTHTAALRELRRGGSVNVDSSVLMWALRDTAAMGTSLLQRVNSAQPPLQAGRSSSYQLVAPFLVQKPSPLPPSAPAAMVETAAAQTEPVSATQLSPALTAKAQRSLPLASPACLSNGDSPVACGDGNAIPKGAIGVVEPIDVTTGTLVPLCSRSGSDAEASSYDGARGGRGERTSGGNSTTRSAQPPAVVAAPRRHSPSASSLPFAGRQQRLTVALVSSFKPPHDSISLSLRTPAQRQTSPCKSEPTTPALINITASGSRDAPEDVPLPQCMDLFGTLQPSSAASTSDVVSVSNGGDGVEGILTPRSHMSNSADTCGTVAHTHNTNLHAASSVTVTTGTVTLTQPNTPRMDVGSSNAHYFVSGSNNWLLGSIRSTDGDRAGFVVGSRRCGGNLLSTPPPTNSEIVQQIRQPTMKVKSILRKPGGIPTVAYGTTVVKDGDRANTNHAHVLQLSVNGGEVGGGAEMDANSTPRMLDNSGTAGSGDERALGTPSSASQMGLQTDFIVLRHTASDSDYVSSVTTTADALSSPAGSRSLMHCGTQKGTWFQASPHTSESAANNSVSGVLRTSIENDCGFLSGAVHGPGNVGTDGTSPSAVVYRSLASPCRLPWSLSTPRKLSPYGAQQRCSNSIDSGGGANVGNVSSGGTQEPPQSTVTELSTLFTPDAVVAVGRTPNEPPPDIILASPPPKRVHVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S6C2</accession>
    <name>A0A088S6C2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_170680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697759.1">
        <property type="nucleotide sequence ID" value="XM_010699457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S6C2"/>
    <dbReference type="GeneID" id="22573811"/>
    <dbReference type="KEGG" id="lpan:LPMP_170680"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170012800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_170680"/>
    <dbReference type="eggNOG" id="ENOG502SBBX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273270at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="585"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="655"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="744"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="811"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1080"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="589"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1194" mass="127510" checksum="8519DA7665018CE2" modified="2014-11-26" version="1">MGTTTTSAEPTPPPRLRDAIKVEPSTEDERGQQLPRHQDVASSPSALNFLALWRPFTVPSSRHASALAGAKQSDAVKGAQSPSSPTTPSAKAVPTHVNDPRLGTLFIGSVVFAPYRVRSERLVRGGSSVCVSGGTASGSSVTPAATHQLVPPPPPYHLHYALAEVTGIQMMAGTVTVSFLFTDPGIDDETVSMYECVPCPPVCLSRWLREENSPAPPRCSLLERVLEVTPQEGPLPVNYVYRALHAGSSTLASASSSSPLLVQRQRQQERCVARLSQLYCLSDDDDDQQSPSTVTRYSSGMAQGMLTQDMATRPVALEPTPSPAAWRLHSSAATDNVALTLNSTGIVTLTTSPATMFARYIVPTSVHVFFSGIFQQVNTYMELHCSRHRRRSLADPATELLSSQTRRLSRGVPAPLVLVIFDNYATLRRFHVFMTVRGHVVQLLDGTHVSSALPSPQTSHAFGAQCKIWLCMLRDDTGEESVEEMTKQVDGSLITRPDAGESSAEAVQAVAVMETQIRRLLAGAPPVDALVSFKEHIMQQQENITERNQSATLHQHVTAEAVLQRLMPHLEADRLVFALQDVPAPPPRSTSAGNSAAASSTEIMQPPPSAGATTTVVKVSGAVFGDNKVLVPCSPDQLTLLSTVLASTPVPACEKTSNGGITERDGETAAQRKGSPTTKATRKRPRVVEMADSSSAAAATRTQALTPALLERIALGSFTDTAAATLFDVFADATAVVEKGPVPSSMDVSAAADDKHRGSGAGRGPAEVLGSIEELYEKWYVDPSRFGEAFPVFAAVYALVADVFASVSRFRSGRPRSGSGWDPGIGNDEPRRLSTESLGSDPSLEQAAETHTSAVAQRRLLPPPLPNKLPRRCLGTLFGALPRVALVLPRGNPTHHPNLSTKQYLRTLRAFFSPWAVHEITSPGPSVAVSSAAPILWHQRGGLLLLFCDEPTTQLGALQDEADVVIACGKAAAAWVAANSATKASSGDCGKGAATGPVLFAIISEAEVVAPADQLTHLWLPITLASPTCTREAHESAHTSTSADGLMRYGKWPAMSNEETSRAELEEMWRLLVATVSADGSVDVSARPSPPLEQDQQRGETLRCAGAAGRRLHQAEVLPRTLRQAVVLWRHLQTAEATMSDRQPQSCASPSEFDNEGPWAVLQAVVKEMALSCVTATPVRMTDVTLIRSSGDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S6L8</accession>
    <name>A0A088S6L8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_171230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697814.1">
        <property type="nucleotide sequence ID" value="XM_010699512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S6L8"/>
    <dbReference type="GeneID" id="22573866"/>
    <dbReference type="KEGG" id="lpan:LPMP_171230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170018600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_171230"/>
    <dbReference type="eggNOG" id="ENOG502QRRI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268593at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="317" mass="36550" checksum="F0710D4A2556803B" modified="2014-11-26" version="1">MFRLPSFAPRAAAVPAARASITALLTASRQYRIIPHLYNEIEELAETQRRGRWSISHRNCLQQPLKKAEIMCDKLNLRESRRSGVLPEKSIARRLSQKYAVDGKVYESESKTKIINLTVVNFDGHPFHFRLYPMPDVTLNTLIDGSGMCHGHATHWGKCNNPDCADWNHGDGCMVNVDIETLDRLLPPNRWEYTSLTAWRATDRPDITFNTRFSCQIPITEELDGAVFALKQLWTRALRESVSDWGLVDDQATIHSARSKRIEPWAPILEEPTKVDFPITWDMLWATGYQDIMKEKYSNFRRKDGFHTKPEMWAAYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S6W8</accession>
    <name>A0A088S6W8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNaJ family chaperone protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_181050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697939.1">
        <property type="nucleotide sequence ID" value="XM_010699637.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22573995"/>
    <dbReference type="KEGG" id="lpan:LPMP_181050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180013500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_181050"/>
    <dbReference type="eggNOG" id="ENOG502QV6I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="240298at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763:SF59">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="444"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1137"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1364"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="464"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1137"/>
            <end position="1147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN97286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1443" mass="157772" checksum="89A95A615A006204" modified="2014-11-26" version="1">MPAPTGSPTKRSEKCAPAAPPGGDEPPLSHSECRETTSGIDVSAAGLQKGSTATAPTPAESRGAIVPRGESRAAVRPRSPAPAQHSSGALIPFNPTTRCIAIGAAKAGISIADGLLLSSSTVLNPVISASLVVYESVKVLQAYHDGNLTALGYRTTKGDVALHIGKELTTMGFGMAIGHGVGALIGLSAIPVAGQLAVTTVLSVGLGICVGTLLTHYVDRFMARLQLRNQYGYPVDERGARRRFEVLMERRHDLSTLGTCRIVQHYADYRVASGWESPNDLVDYRTSGDITRMPVSLQHFAAVQLQRKWGFVKERAQCRQVYRALLLVHHPDRGGSTELAAQLNKDFELFAFCQGWDSDCASLLRSAEGRPGTAAHADGASRRRRGNVIVSYLRSLFRPATNSRVGANDLHQFGLLALEAGTPAEMHRRDVTAALSSFSAAGAAGDGGDEAAPEKSGSLGDIDSVSDEDDYEDTEAVAAGRQRSVTRVLRALHEVYKATAEVITFSGLIRVSDDPRRWAQLRQDVGLFQRLQYFISLRAQALAATPQESTGHAAANHHREKVQPLGAAKQYIFRAFRWSTVQEAVAKREEVRGAIVAAVFTRETSQQLTSLLELWRTAKAMAESYFRACQQREADGRPATSRNEDEGRQTLDALLRIHTQIEAAGTAARAPWQGRMEEWATRKVPGFSSFGEDVKEIGLTASNALAADYAAHAFATARQQCSEYFKAWGRKQETLRILLAELKLEYAALRGDVQRCGGDAPPSTAPGLACSPEAAKRIDDYQTQLLLLQKQMAEVDVGVAEWANTCAAHFPELTATLRQLPSTCVESVVGVRKESHVYGHSLNEEAPTRHDWTPRFVAFERERTLLHYTCVEVEPVNPLDSLTSRLPSHDSSDSAAWGKPAMGGQEGDVIGALLRSFEANEVIEDTVVSPQGVGMTLLQALYNDPLTGEITPCWLKRYSFAGAQGREGVRSVRTLAQRILAEEVAVPGMCSSDRVVSARDVFYNRERQEMFVHYVRGATQQRFRSVNDVRRQVEPLGLRWLHDVLECVVCLHACQLVHGHIRLGAFTYDDFGNTALGVFYPTWEGFNSVSPATAEEPTVVTTPAPSLADRQYCDVMGVGIMLLTELLPLFNAARSSSATPALPPTSRQSPPLPGGSRTEGDAASDDMARVMEAVAAHLVGEEEPRWSLLDARQFVRRFLELRSGDFDIFSNQVAYPASWAIHGAAPPVQLVAVDATPFHFPAILTASAAAVRVYHNRHVSLWETYWQCRRKMASLRRGSHMLPSMVAHAPPILLCSDDFEVHERYLWCACAEEEVAWEHCQDGFRSLRRGAAQLTPSNDMLPFLLGAPPTRCDGCADLWGVICRVALGTALEETEEEFAAAESEADMTTAQYNKLSYAAQRRSHLVTRRLAGTGRQAQQPPAIWVPCPWARCYPEYVVHISWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S772</accession>
    <name>A0A088S772_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_190780</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VPS53 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698074.1">
        <property type="nucleotide sequence ID" value="XM_010699772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S772"/>
    <dbReference type="GeneID" id="22574132"/>
    <dbReference type="KEGG" id="lpan:LPMP_190780"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000036200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_190780"/>
    <dbReference type="eggNOG" id="KOG2180">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261632at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.110">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 53, C-terminus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039766">
        <property type="entry name" value="Vps53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031745">
        <property type="entry name" value="Vps53_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038260">
        <property type="entry name" value="Vps53_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007234">
        <property type="entry name" value="Vps53_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16854">
        <property type="entry name" value="VPS53_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04100">
        <property type="entry name" value="Vps53_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps53 N-terminal" evidence="8">
        <location>
            <begin position="27"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Vps53 C-terminal" evidence="9">
        <location>
            <begin position="629"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="51"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN97421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="880" mass="97744" checksum="4307AD52D780EB5C" modified="2014-11-26" version="1">MPVHYSEAVELAMAEVCPPRDAWDAADFDPVVYLNSRFPDETSLGALPAFLDEANERLRKAENQLLKAVEQQASNASNAESDLKGAKEAVAQLYVRVSEIKSQASESEEIVKDLCHNICELDVAKTNLTSSINTLRSVQLWMLQLQVLSSSFEKRRFLQTRDALQEALKYSAMFEKMKDIPKVKELNDKQTQLCRQAEYYIRNTVFGELNLETIDENLMAEACALVDLMEEESKKKLRDRFTDKLLESYSLRFKRDTDDAKLERTERRYVFFRGLLERYDNVFKNVFPRHWCVPQELCVTFCLHTKQELDYALREAANKIDVVVLTYVIQKTIDVERDLTQMMTWKDEFAGKRELPVYKYNGMILSAFKKHMGLLVQNEDRLMQEALAQPLIGSGDSLFSCWNSIEEEARSGTYLPIAEDIFVFIKESLKRALRIAQQDVLLEMAEVWRRHLIELAQAISSLLPSPAVNPLERRRACIILNTADLCQSTSQDLGDEVCTRSEAPPREVAFDQVKEAFSSVYTKSIQSILQGLELQLAPMLVDYGNGGFLAKKGTAAYNANSNGAADESKLVRDMTATVHDAFLGCAAVMPPTGLRFLLDKVAATFIPEYGNTLYRLRRLPDDGVSCMRVDAAALEKTFLQLPNYNDPARFAASALTGYMRLVRREFDQLNRALKVLQVDARTDAFIDVYYEVVLPENRSIHNFVRLVELKGLRREDVRAWVATLSKRGVVEATKRDLQREASLGLSTGVSSSASATGAAGSATSIASGVGLNFAALFTRDASASLAPSRLPNTGAAPSPTTGGHFSLSNLVSTIGGGELNNTAVSSDGARATTSREGTTAAVAGNGAAEEDGLGSIFATVARNTATSMNFLNKFKRGEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S7U7</accession>
    <name>A0A088S7U7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">AAA-type ATPase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LPMP_201420</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698343.1">
        <property type="nucleotide sequence ID" value="XM_010700041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S7U7"/>
    <dbReference type="GeneID" id="22574351"/>
    <dbReference type="KEGG" id="lpan:LPMP_201420"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200019400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201420"/>
    <dbReference type="eggNOG" id="KOG0743">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="BCS1 N-terminal" evidence="14">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="190"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AIN97636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="406" mass="45959" checksum="9A1507A4EE611BD6" modified="2014-11-26" version="1">MLQALMRRKFVVSLEVSNRDNAYDWMLRWLSHQKTFKVQQMSVLTRTPSMEYSSSDRMRAECLFSPCPNQRHFFFYEGRPLTLTRRRRDNISPGYSDDIFETLEFTTIGTSATVLQNIVKEAQQFAEQEDSDHTVVYMNGGSSWTRQSRPRSRRAIQSVVLPDGISEFVLSDVKKFLSSSSFYKQLGVPYRRGYLLHGPPGCGKTSFVMALAGELRLSISLLNLSNRNLNDESLTSLLNEARVDTIVLLEDIDRAFSNECNVTMSGLLNALDGVGAQEGRLVFMTTNHVDLLDAALIRPGRADVKIEVGLLDVDQSQRMYRKFFPKATEDMVEAFGRNFPPHVISAAQLQSHLFFHRDDAVAATVALPTFIASTRAFDASIEQMRSKKARLQKSLPRAPLLDFDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S857</accession>
    <name>A0A088S857_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_202700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698473.1">
        <property type="nucleotide sequence ID" value="XM_010700171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S857"/>
    <dbReference type="GeneID" id="22574480"/>
    <dbReference type="KEGG" id="lpan:LPMP_202700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200032800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_202700"/>
    <dbReference type="eggNOG" id="ENOG502S814">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273542at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="377"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="674" mass="72364" checksum="D255B4C7AF264363" modified="2014-11-26" version="1">MNPFAPHGLSSSHPIFSPISRFTTVKCICASRVSTAVFFCPFPGRLNAGACTSDILISITRGASGLRPMSRSVSPSSPSPRVTRVSLETIEKLQDAWSKRYETLRGSPPPPLLNSPRSLRACALANVNPQSTLQKLSLKQHLFCVLGNPHMLSTLPDSGTAEYRVLMQSALRCFSEAAVGLGTSKEKLAAFIAFKNQEELRVPQLASLRELRRQLMAKDVLAKRKRHEEQPDDASSMPICNASSAYRNADGHTAPHHPTSRSSLLRSPTLEENLLWCHGCSACHWADDSPTGAQNAREPSPCHSFLASVSFVAEDGTGEEDDEGATGVGRFDLAPTPSPSGKLPYKPRDVSLLSSYFANRNIQSNGSNPSNALLRISTPGTPSPSSRGVTSVARSSKQPVRSPQPLLEVDSSLDTIIDVDSECVLVRGTAKGSAGLRSVTKQELSIVSINTSQFEELLNIDEPATSSPQKTIAQLSTAAVLAEIQDHMHSNPRSQHTVMLFHESGEKTNRGPAAATTAGEAVNVTIPQLPAELPPAPPSQSLTPRGFRGYTTHTNFASLIVPNMHARPVAPPAEVKAVSTSRCVVEAAMSRSEKHMEMACAKQNVVTSTTVIPTKSPASANSADAPAQSRLRLPPTITKAEESEGFLYYCANPSHSEMSFYAGGRDRFAFTVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S8L3</accession>
    <name>A0A088S8L3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Metallo-dependent phosphatase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_204620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698663.1">
        <property type="nucleotide sequence ID" value="XM_010700361.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22574674"/>
    <dbReference type="KEGG" id="lpan:LPMP_204620"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200052900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_204620"/>
    <dbReference type="eggNOG" id="ENOG502SIWB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1883418at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34211">
        <property type="entry name" value="CALCINEURIN-LIKE METALLO-PHOSPHOESTERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34211:SF3">
        <property type="entry name" value="CALCINEURIN-LIKE METALLO-PHOSPHOESTERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1048"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1103"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1137"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1277"/>
            <end position="1297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1416" mass="158852" checksum="4A2C9658AB0DA895" modified="2014-11-26" version="1">MSEWFHWTVGSANPFVDFSTIWIEPLIQHAVDFSHRVEPDVLCTLAYLACMGSAYLFHSPFRAHATAAMDTYGRVTKVFQTWSTIIFFCFHIGPQLFRDKRPKISSVDTKDTVPILFFPLFIIFTICFGFLHKVKRRWGLSLTYGSRFSVIALNSLVLAALGTAHYAYCHTLRPNASHYVWRFILYYLMPSSIVTQPFWCVSKLLLLSACFITTDYHYKKWMGCDPARGILWAELYELNKGRHTEVLMMERNSKEGQQDWRELVAPPRVYTPAAPNTRTTAAQVAAAAVLGVPVEGRIHGAVCNSSATIDSAARTAPAPRILYHECPPDVNLDLLESSYDADDADLRRICGGVGGVPLREANRIFSASTVDNSPLPHTHLDGVMSRALYKLDHTDPNLTALTSFRAPQLFVKEVQEAQHPVNRPGMVPWWSTFVLLTVWQTVAGAMLRFLSFDVRTIQGYTTPKIFHLHFSSSLRDTIRSATEALSRCTAMHRRTSCDSIANSSGLCSLYAPGNHGAPSHNDEDQGVRKENACIRECCVPAAAATSPLIEPDVWFDWIADVGDGFNPTYAMARLLAQPMLRLPLAATRKARWRRLFPSDEDEVTGVSNYNNLADRASLSSSAPTTPTASMPGAVEEEATALELPRAAPFWTANVPDMSTAGRTGSTTRLQPLLRRSRTHVAAAAVQGSTMRTRRDVGKNLAVSKAATTGSLDLNSSVYPRHTLHRRVASEDSQSTKSTASRSLLSMEKDSFVTLPRGSFVLVGGDLAYPSPNDETYTTRLFEPYHDAMSGNVRLQSVFHAEQQRVIVADASDADVAHVHLLDAETVSEMATGRAALRTGRATAEEALRSVPLLFAIPGNHDWFDGLTTFHKYILERTWIGGWLMPQRSSFFVLRLPHNWFILCGDTGNMQDIDVAQRNYFLDVIEKYMDVESCVILAVHEPGWVYDAMEKDEKARQPELNRVVDALGTRLRLRLAGDIHHYSRHVPVDASSEAATLVVSGGGGAFLHGARNDSIISQGTKYVRACAFPDRNTFMNMASRLWGFRVINWKFDLVVGFLCFVLLLSVLPLPMDLDLNSRGTTHRGGKKMRLAQVFSLWVGYTTEIMSHVITRGIISLFSLVFFWVFFSSAGVDRHAPFLWRLCYGSVWAFAVLLCCSGAMAFLHVQLLYLMNHELLESTGGHWGSQLENQVVFMTNALIDYLQSITGGEGSWVSRRVSRAHNPVLAIIPTGCLRVLLRCFDPFESLSFLSMTVSGGEMARFSATASRFQILLYYTYVLFFYWVLITPIVSVLIGTFLLFSVTTFDYMYNPTYSAFQMEEYKHFVRFRLDAATRELHAYVVAVQKPATVYQLDRGYLWSLTGPGLEEHRPPHLKHHPSRWGPVPSDVQRKRHMTELLEHFTVYPHRGPQRSKPLKMEHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S8Y3</accession>
    <name>A0A088S8Y3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_210100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698798.1">
        <property type="nucleotide sequence ID" value="XM_010700496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S8Y3"/>
    <dbReference type="GeneID" id="22574832"/>
    <dbReference type="KEGG" id="lpan:LPMP_210100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210005700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_210100"/>
    <dbReference type="eggNOG" id="ENOG502SI4K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271900at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="347" mass="37756" checksum="713833FB38A9B987" modified="2014-11-26" version="1">MAASTATQNTGGCSSEPHEGRLRLVYAAHQSLEDDLSTFLAFSAAARKHDEIAGPTNEGFSPWTGVMESATKCIGATSRCLRLFNPTRTVTQSKGMTLLTKLYGTGAAPHERVSTFLSHIREAFDGVLPVEIALSGGHCLRRLDPSAADEYLVAFIIDWVTLAEEQADPFRRRFRELLSTHKPFHFHFRAAVLLQIECAALSGHNKHVFAAYNTQALDSILTPVTREELKKYEVTCWQDAARHREVESVAAAPFASAAPVSTTSAVLAPYKQQETQRGTSLGMSRGGAVTPSSSGMANWRRDAIRIGALLLLLAVLLRLVSGPLARLLKRALQVARAAPAHQRTLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S9Q6</accession>
    <name>A0A088S9Q6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_220780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699078.1">
        <property type="nucleotide sequence ID" value="XM_010700776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S9Q6"/>
    <dbReference type="GeneID" id="22575124"/>
    <dbReference type="KEGG" id="lpan:LPMP_220780"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000041400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_220780"/>
    <dbReference type="eggNOG" id="ENOG502S6IP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273744at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="503"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="703" mass="74965" checksum="69153B7494A2BB81" modified="2014-11-26" version="1">MSTSRKRYRPLDPSEERAVTVHERLQLLPLEDEQSYCFSWPEASLTQWLQKDVPYASLYQLYANAGGGIGSGGVSSHTMRGQSSGLVDAGVASSVLDFPKGKSKVATLSSSGRREALSVSSSTDVTSFSALHHQRNVEVPPVFLLDDFEPALAKHGQLLKASGGEGTASDAQYGGADLQRLLRRVRDAVKAARHDSTGTASVVKAEVFDSKDGASPTMPAPSIVLQSDATTRLTPHPLAPPRPQSIAEDSIFSLSATQLVDLVAAGVPALYASAARGNAQRPSQYIEAPNTPITTSAEDLPSGEPSTASRTTGYVCSCHDPQRCAELSESARREIEHEVVGLEWRTWSQSQRTAAALQRLLSLEAAVPFERGGDAQRDAWRAAVYRLWLQWRQQRLPPIPERAAAGGSAESSTRAATLSSGFSGASVVPSVPASSYGFAAFVSPSPATAALVFPEGALAPSRNHPRLPWGAPLLAGAYLYGTSNDYFISLPPSTTSAPGHVSNGGSSNSKNCGGSSLWPAMSRRRGTYSFLRWKVELYEAQLSRAAAAAEENEENVDDGNEAVEGDKGKGVDSRDRGGNDSATATKVRRYSKGPLGGPETDASASTYRSRRGGDDDRGGSAADICHFAGRKTVTTTVASPTGHTAINGVMSVSHMKALLYTTVLTQPLTELEMDDEPTTVMERLACPDLRRDTEAWRVWLSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S9Z4</accession>
    <name>A0A088S9Z4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_230090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699168.1">
        <property type="nucleotide sequence ID" value="XM_010700866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S9Z4"/>
    <dbReference type="GeneID" id="22575213"/>
    <dbReference type="KEGG" id="lpan:LPMP_230090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230005700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_230090"/>
    <dbReference type="eggNOG" id="ENOG502RP25">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272604at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="112"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="366" mass="42198" checksum="839FAB2BB90ACC81" modified="2014-11-26" version="1">MRTVNEMIIRKKERQHGEGMARGLTISPESLAELKSLEDALKLESQKTVGLQNAANVTLRQMEEVERSLEQTEKQLVKAKRSTGWDIDRNSACTETAVESEFKEKKKQLSSLASEQRTLTEVSERLKQQAAELQSKIDATEDMDELFAEAEEELRQANTRYKELNEQVKSNERIQKKTERVLTVANTQDLYKPIRQLEGDKRVLHCNLSKLRETNVSNSKSILSLEVRLRQLETRLEAINGFLREVFAEVEDDEPMDNVPEGSAEVPLAQFEELSAALELSRETVVQRDDQLDEHDCKIEQLERKIIILQNAITSREVSSKVQSRGRDKQQRDMYLAYSRRRWKLQAERDQLAAENITLRKKLASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SA54</accession>
    <name>A0A088SA54_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_230760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699233.1">
        <property type="nucleotide sequence ID" value="XM_010700931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SA54"/>
    <dbReference type="GeneID" id="22575280"/>
    <dbReference type="KEGG" id="lpan:LPMP_230760"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_110008200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_230760"/>
    <dbReference type="eggNOG" id="ENOG502SCBG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="252800at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39668">
        <property type="entry name" value="HYPOTHETICAL TRANSMEMBRANE PROTEIN L6586.03-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39668:SF1">
        <property type="entry name" value="T. BRUCEI SPP.-SPECIFIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="261" mass="27127" checksum="EB30225A70F52310" modified="2014-11-26" version="1">MGTGTGCLYACAPFTLIVSILLFMLSTMLHNGNWTFAVLAAKHKWDTSAKSRSCRNGGILYLFISVVLWALVLVDSFLIQLEDLPTSASKWWRQRRLPSLQELIRKRRKASEAEGAGTATDVIVMTPTPVAAARTGAANSPQRSSLLALPPSSAKVASSPNLVMTSGHVTVDDSRGKASSAGPVRGDTGSAGFTLSCPSPLAVGGSLIGDKAVISSAKALSSAGRPYESVTSGAVHAHSVLPVSTSTSAATSILEGDYLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SBD9</accession>
    <name>A0A088SBD9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-tubulin N-acetyltransferase</fullName>
            <shortName evidence="3">Alpha-TAT</shortName>
            <shortName evidence="3">TAT</shortName>
            <ecNumber evidence="3">2.3.1.108</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Acetyltransferase mec-17 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_251180</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-lysyl-[alpha-tubulin] + acetyl-CoA = N(6)-acetyl-L-lysyl-[alpha-tubulin] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15277"/>
            <dbReference type="Rhea" id="RHEA-COMP:11278"/>
            <dbReference type="Rhea" id="RHEA-COMP:11279"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.108"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase ATAT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.108" evidence="3"/>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699688.1">
        <property type="nucleotide sequence ID" value="XM_010701386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SBD9"/>
    <dbReference type="GeneID" id="22575766"/>
    <dbReference type="KEGG" id="lpan:LPMP_251180"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000019700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_251180"/>
    <dbReference type="eggNOG" id="KOG4601">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="447510at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019799">
        <property type="term" value="F:tubulin N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070507">
        <property type="term" value="P:regulation of microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000166">
        <property type="entry name" value="Alpha-tubulin N-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03130">
        <property type="entry name" value="mec17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038746">
        <property type="entry name" value="Atat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007965">
        <property type="entry name" value="GNAT_ATAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12327">
        <property type="entry name" value="ALPHA-TUBULIN N-ACETYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12327:SF0">
        <property type="entry name" value="ALPHA-TUBULIN N-ACETYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05301">
        <property type="entry name" value="Acetyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51730">
        <property type="entry name" value="GNAT_ATAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="21"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="site" description="Crucial for catalytic activity" evidence="3">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN98981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="236" mass="25909" checksum="4E76D0007F215561" modified="2014-11-26" version="1">MRLSAQLTNTKLADEQVPELASVPDGVSRWTGADLDRLRSAARRGGVGAEQQDLAQKLCRTIDILGARSQKTQGLNAVLTSVARLRESNTFRLYLLTQNHRGVGILKMGVKKLFVTHPVTCGLVEVDPLCVLDFYVDENCQRQGYGKKLYAHMLDAEHVSRPELLAIDRPSDKLLGFMKKHYGLTAYTPQVNKFVVFHGFFGHTTVSERGKLLRTTSPTGAAAAATGTKAKNEMPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SBY9</accession>
    <name>A0A088SBY9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_260770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699898.1">
        <property type="nucleotide sequence ID" value="XM_010701596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SBY9"/>
    <dbReference type="GeneID" id="22575980"/>
    <dbReference type="KEGG" id="lpan:LPMP_260770"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260012500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_260770"/>
    <dbReference type="eggNOG" id="ENOG502S033">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="274923at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="132" mass="14634" checksum="3CF2D49BF5BBB75C" modified="2014-11-26" version="1">MLRCSLRAVLRAPVFCRVIDVMRHHEPYARAGILYPVRVELGEGVESCTPAELQEKIDTMLSRSKRFATVKTGNVYLRNNSVATVIKAYGQYVVTGSMRGGYVKGDHRYGPRLTGYGGATAKPGLRWNGDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SCL4</accession>
    <name>A0A088SCL4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_270690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700158.1">
        <property type="nucleotide sequence ID" value="XM_010701856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SCL4"/>
    <dbReference type="GeneID" id="22576245"/>
    <dbReference type="KEGG" id="lpan:LPMP_270690"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270013800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_270690"/>
    <dbReference type="eggNOG" id="ENOG502S30U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272649at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37561">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37561:SF3">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="458" mass="49153" checksum="C10495D4F3739765" modified="2014-11-26" version="1">MQNSSYSHLVQQPRGGQGMPDSPNIGVPPSTYPPKSPSTPPLVFTAQCGGVPAQLQDPLSSSLCAEPLQMSYPTLLGRHNSCTLIEVEDSPIKVTCRTRGGSRSPYMAPMPSEMAADTDRSGRHNPYSFSFSGSSSPRQLTTPTHSPQINTFEMGGDPFRRMLCGGPCHGARPSAADAPLMQGHSVRLDTMFALPSEVVHRSLKDRCRYIQFPADLPPISNSGTAGPHANNGNHTSSNGSTGSGFSGENNLPMALFIGQVRFETTPAELLWLVHRTCGACASHLESRGAGCYLLYCKSEADLTLVRSLHKRILFDIGGVWLARTADEVDAMCEYIALDAPLLSKKARLPRDSMVVEELKADAVNSGGRRAHGGGGGHERRTFSDNSLSGHCRGGGRGSSAQGSGVDDIFQAAGGEVSQNIRRQQQQQRKREGLPSYEESALPYPGYPPQLLDGCPLYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SF39</accession>
    <name>A0A088SF39_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Calpain-like cysteine peptidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_301990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701222.1">
        <property type="nucleotide sequence ID" value="XM_010702920.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22577252"/>
    <dbReference type="KEGG" id="lpan:LPMP_301990"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300024100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_301990"/>
    <dbReference type="eggNOG" id="KOG0045">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="424753at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF423">
        <property type="entry name" value="LEUCINE-RICH REPEAT PROTEIN (LRRP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="3">
        <location>
            <begin position="271"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="763"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO00422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1363" mass="149613" checksum="C904BFA69C5E5E2B" modified="2014-11-26" version="1">MSYYVGYSQREIYKKRCNELNCACNSAVVQLLSDVPNEVASLIALDLSSNFLGRKGVIPLLDVIEGATQLRSLDLRDQQLGNEAVELICVRLRRHPSLVKLNLSNNPITLAVSRALLELAKQNSVLQYILLEHTFMRPSMVTVIEVQLEQNRARARAASTVSAMHEDKTSRIATTTSSDAGTSVVDVKAGSSRSEQIVLSTPAGGGIAAAVALLHSSAAPMTTGSSELRQRIPAHELQHVLRYYTHAVADVLYDVNPTQDLWGWCEARQYMFDDDQFNSRNNHLHRTARHRYSIAGWRRVGELYPDATLFGWESATRLSNGTAQPSAADFRGSGLQHTCEGLIGGVMDSTRAAVGRDRSSSGAAYSDATSVLWQLPTDVPPGFTWAFTALMASMKEMGSLHTLLCASATGLPDGGMRVQRGTACPGIYTMRIFVEGQWRYLLVDDFLPVDEYGRLIFTKLSMDDKAFWPCILEKMLAKLHGGYHALDSHFDQHHVDIDSSNIHKSIAGLFLSKENLQRATGGGGGGGAAIVCCGGNDADWDAMPGDSLIGEGVAKNCGCVMSRLTRGLYDSYQLHPVEEAPTTKVFEVLHKTLGVPLCKADVREGFDIAPSSRRGASVRRSFLGARSVSVDVPASVPGLSSCVTTAMAFSRDVSRTFNGIQPRCGYQIVRVCHTGGVRLLELCNPWCGAEKWTGDWADDSPLWKRHPEVAEILLTRARTGPSAQSDGCCLLQRPSVTSRLINTSLKRSLLATLSETGESLKEMKLSTPPGSVTNPAGHPAPPRTHLQKSTFWIAYTDFLQNFEWVHTCRIFGDEFYRQDVHSAWSRDSAGGNAREPSWYMNPHYRLSFPYRSTVYMQLTRRDPRLRRTRDVGRGHQDCVGGIGLQLLRDTHYPLHCPATSLRDAALGTIAYLPSGSTEDIVAGHRKDDDNTNDVVRGRGVGAPDCGDNSAFASVFSSEVRQIGDCLSLEVMLDAGAEYWIVPTTYAPRVLDEFDLAVISTSPFMLLEAKESEYWDQRTVPPELLRSAPTGTQQVGQTEGEVSIIFDSKTRIASDANLLLQDTQPKRNKRLAHNSVRNSSESASAPLSSALCRVVVAAAVDLAAADEDVTKLCVNEAYERPSLPVEDVMGTPTLQLAIVPGEVDGKGHPTRTVGEIDPHAAHTYALDHHTVLETVLTPVPLNSAEYYTVICALRPAKMPVQVHYRVWCAAPLLEVMSVPMWSKQEMVLCWDDEKGSASYYSGTRHPQVELSKLRPFQRFAVSLRMMDYDTIEPAIMFSVVVNDGLQGEPVEGRLEDRGVWWQSAYVNGTYVQGSFDLDEHPPESLILIACLQPTGSRGKCILTISSDSADYRAYPLRAVGAHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SHA0</accession>
    <name>A0A088SHA0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_322870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701972.1">
        <property type="nucleotide sequence ID" value="XM_010703670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SHA0"/>
    <dbReference type="GeneID" id="22578028"/>
    <dbReference type="KEGG" id="lpan:LPMP_322870"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320035000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_322870"/>
    <dbReference type="eggNOG" id="ENOG502RT04">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272672at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO01172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="991" mass="106686" checksum="F3F3C2902A08C605" modified="2014-11-26" version="1">MSRADKQQHQEHVVGTSRDTSVRLFAFANTRPSYQVVFAPEKPLIILKSKKSASPQHPCLQWESLSTLVFQARPNTTHAIYVADTTNLSSVTTYDQEEHVNGAAVGPLLKRLSNAIARLNPHNATMVAAGVSGHLAMKYVLVGEKTLGHHDRLVQRLVLVCPTPLSSLTAMTNAVVRRPLVDGYQLPDIVVLLKEQTEVLAWSAWLTALQDVHHRISSFHITTNLAPSLFAAIAREAGLAEADGTVADVHQRYAVPRVYRLDFVLSKQTKSVVQLPRLSPLDTLGYDDDAGEDGDFIESVDEAVAAGSSVGVDESCCGCGSEGFCGNRGHGEERTEGENHGSMLVSGLHGLASWCDPVRVVLEGRVLDLRAGLVGTTDGCVEVTNLLERVTADSALAAWHARAVSANQKARRQRPPAVAVAGALTRDDKGRTTLRAEEVRPLTKAEARYSMMAGSSLEEIPVHYNASRIAHSYGALLIRGRKCALARTVKGAVDARMRIPFTPHSSAEESCVDCAVRALCDACEVSSDNFFLPSYLPPVTFYPTATADDAGPRCVTIYTALAISPPSRGVASDAVEDVPEPEEPYDWVTFSRALTLVETEVEREALQEAQVHLKRAHKAGLYTPVKGCGLFGEGVKPRSDGEAGAVISKGALTGIPAGAAHRLKTLAGIEFYVIVCPGGVAAELMPLLTQALHTTCSLACDTETTTSPIEDIAAEAQRRGERHVLLFLGGDDDAEAFCETHLLYLTEERHATAQVFTVLLPQVATSIVELNDGVLASEVEARLETLLSAVRVSDALLTMVPLKELSRTEHIVLQVCCKANPDLMLFDSWEARCPFTLCDHTPGGSGSASDVGATPILKEMKVRTPAGVPVAPASLAFLTHAGALDCFYAAGEYRLLLLQGDVWVPTRGSTQGFVYLDLVSHCLVVEPGKEWTSASDAGRMSELTLLVWCANDAAADAAAVHVATLEKELQWSEARDGSDWLLAYDPLPQWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SHD8</accession>
    <name>A0A088SHD8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">MPK6</name>
        <name evidence="13" type="ORF">LPMP_323430</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702027.1">
        <property type="nucleotide sequence ID" value="XM_010703725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SHD8"/>
    <dbReference type="GeneID" id="22578084"/>
    <dbReference type="KEGG" id="lpan:LPMP_323430"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320040800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_323430"/>
    <dbReference type="eggNOG" id="KOG0593">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272141at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07833">
        <property type="entry name" value="STKc_CDKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000049">
        <property type="entry name" value="cyclin-dependent kinase-like 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001173">
        <property type="entry name" value="Mitogen-activated protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF400">
        <property type="entry name" value="KINASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="4"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="302"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="586"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="708"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="822"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1033"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="306"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="595"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="714"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1056"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1094"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIO01227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1108" mass="119463" checksum="0C82E2F8D79C31DB" modified="2014-11-26" version="1">MESYETLGILGEGTYGVVVKARSRTTGKLVAIKRFKQTEQDEHVRKTSTREVRMLQLLRHPNVIRLEDVFRREGKLYLVFEFIDHTILQLLESTTRGLSRRELRRYAYQLLRGIEFCHKHNVIHRDVKPENVLIDESGLLKLCDFGFARQMSAKGKYTDYVATRWYRAPELLVGDVAYGKPVDVWALGCMFAELSDGQPLFPGESDLDQLCLILQTCGPVPARMVFIFEHNPLYSGVSFPKTGIIYTLKERYHRESDDWLDFLSSCLHTDPAQRLTCTELMELPYFTRDGFRDRYEAELRAATGLPQLQSTPMTSTPSTQRRVPDHAAGVGDSLKADPVVSPSMPHSSEIISPKLQGQQPLASNNNLSDTCLSKAPLEAVLHDANTAKGKAAGAPKSTLLPPHTPASDQSMQLPMILNGNSERAIAASLTDYLHQEPTSSSVAASPPVGAAPTEVAEGLTNADLLAPSCEVVSALQASLITNTLAMRDRKKKRYSSVAATELHRRSGVDKNSETDCAVSTGDNRGGLAKHISCHSPRSTTLPSSGVHGGGGCYGLGRDNETMTVSPPSMSHGVADSNMRVVLTTAPPGKDGDETTVPTHRASTPASADKLRTTATTILSSPSLAATHVAPLEACPQDLPALSRHLPHHLEQERQAAVVEQLQSRTPSSVETLMLSFRVRTRNPLASLSLENEGLSHSKANSEATELSAAKTHGGISNSSTYTTSHVASEAKKRKLSRHKRETRCVYDQLVASVKGSGSHCSVPGHAVDEDAYHTEIASVASPSRPEASLLLSNVPGKQQQHLLGSEPGGTHVTEQHLHCVGAGLSAPDSTHNRSVDAHGPLQRKERRSKPLPGSTYALHNSDQRQRQQPHPRLDGSLQPDGGASQRATATLLALSALRNVSGPPPTKSTGDADKCSYIHHIRSHINNNGGEAVSFVVGGDGKGPNTSTTGRARRSLGVYALHGCSGNSDETEATRRVQKKNLFMAHGRTSNGAAGCISFPDKYTGPSCHAIGSLHGAPYNSFAKASKVEGEVGGAQQRQSLRKPPKKIAGNRGSGIVNTSSIHSLRHSLTTGRQMQHQQQLAKEEGGNGDGTARQFNAATAASPYTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SI97</accession>
    <name>A0A088SI97_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_332560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702347.1">
        <property type="nucleotide sequence ID" value="XM_010704045.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22578409"/>
    <dbReference type="KEGG" id="lpan:LPMP_332560"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330033400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_332560"/>
    <dbReference type="eggNOG" id="ENOG502SFG5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267643at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="359"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="743"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="894"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1172"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1468"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1537"/>
            <end position="1625"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1141"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="758"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="800"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="894"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1172"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1203"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1559"/>
            <end position="1577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1591"/>
            <end position="1625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1625" mass="170653" checksum="751AC9CED7BCC5CF" modified="2014-11-26" version="1">MTSLDTAVSDAGPLVERAARAEATPWSTETFLDFTSFRDAYSAWHESEDFFNWLQSSSYAVALLAASNLRPLHFTARERGTTPTASSSHAVEASTVHLVLRAPCCNTTVVLSEEERVTLAKVGRLFPFHVGSKGVATQSKKSTVIPVQSTQLERQHQITAGLLARAHRDGCTWRDRHALGERGGETDETTVSCARQLLLGSPSLCITESVTVRAFCAAVTLRSLGSEAATNAPARVRSLLPRGSPPSAVRQRMAETMAVLDPAFSAVHCEASTAVPRMRYTGSNVNDRILQLFFASKKRLRPEASTEAACAETDTRGKEVLRYIALLMSLYGYTVVPADDVHSTDTENAGGNEADFRDEETTVGAGSHQPSPQETSQWKSPSTIQTSADDAEVGHHMHTETATQSELISVEDAAKLLGWHARCQFCAHGPAIVAVRERVTRTTTTTITTASTLEVSHIASCAASLSTAEALRKELQCVVDEKGDALQLHGVVGASVESGSGDGGDGGSKDVLGVVAEAEAPLLSANCSQQYGKMKDEAFVAAATTTELENTSDDLSDIAKNYGSILEKGVSSQEYEEGDCAVSATLLSSVDRGSNGGVEDDNVCVSNEVGSSISGNEETAGEENLEAASCSDVEALGEQSTQMCSGVALVQAEASGFCRTTAATTTTKVVTRTTHSVTTITITFSRCPTLQRDSQQQLQHQLSSTSGKGHHDSCPWYRLFLTDAIDATALAAPERFMDFTWVTGEDGDTVPDERTVDLPNSTSTSMTTSGDQTKGNAHKSEGGVSVDGEARFLPPQDPSPSKREDQTCEDSERHSSRVILVLRFLLPEVERLITTWRLSEEWERARPGEYLRHPLWRTWLTSETLHPVHTESADGIMEQYLRTLERQLMPSQITEEGTGEGSRSSAAASDGKCSDGSVINKAATRVIGKAKWDALGTLEEFVVTMGAPLCNANTTLLSRTVESALHLANRSLHRYFANDQVAAEAGSAARSGDARTLLREGLQSLLRFSGISASQSVVASSGAGLKSTLSAPDSEDARGKEASAAVRAFLKIMEERCADDIVRESSSNASRLRRALQREAIPHALHEFTTTVYPTLRSRAADCTTTTDDLAFLVNTASVSTNADSCHTLCDLDRSRVAQYLQGMRNAAQEEQLQLQREREKAVEAQRLAEAKAASVSTAAAATTTTTSSAPVVRAPATRASASKGPARQKQQQQSQGGRGPHSSPHPSTLPSQMQGLPMHQAPAPSHSNPMALAPHSTRTSSGLAVLQSDVRPTVGPPTQPLGDNNPHWGFPRPSLHGNTGASSPPQPSLMHLQAPDVVGNKALPPTRAPFEGQGGGSEPCNPSAGSGFFLASNVIPGGGQGPIFLGNDRSGVGLDGSAFADDGGPLFSSTHPFGWLPFPSRPSGGDDAGVLAANVYAPTSGGALPRGSASGLSPSAVDSVLGSFDGRHPRSDGAATAEVSRLPHWSSSAVLQGPPTGDTGGGGVLGQSELSVLRRESTASGNRIVSSKSASTVFGASAPSSFAVSKATAPVMPSLLVPRSGHANRGRGSGGGQQNQQLTPTPCQPSSRGNAVNSSVLGGGPNAHAPPSRGGAGGGGGGRTGRGRSRSGGVGGQRHGGGGFRRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SJ55</accession>
    <name>A0A088SJ55_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ubiquitin-protein ligase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_342310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702657.1">
        <property type="nucleotide sequence ID" value="XM_010704355.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22578736"/>
    <dbReference type="KEGG" id="lpan:LPMP_342310"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340029100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_342310"/>
    <dbReference type="eggNOG" id="KOG0170">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="423283at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045322">
        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="5">
        <location>
            <begin position="1092"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="6">
        <location>
            <begin position="1911"/>
            <end position="2303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="561"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1038"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1711"/>
            <end position="1740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2195"/>
            <end position="2234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1713"/>
            <end position="1728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="2215"/>
            <end position="2234"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="2270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO01857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2303" mass="253315" checksum="037AFB4A9A62CF7D" modified="2014-11-26" version="1">MDIGIYDSKAQVRAVVAEWKAMNFIGLFEAIDVMSISLVMGFERYLRKFDSAAAIPILVDVCKTFIKENTQGDLIVVSLRALSLIMEHVPSSYEAAQSFHVSLVELSSQAIHRALRTEWTFVQSNNNAMIEEGLRVMRFISKDDMTGELIHRVPLGDLLTLCTDSRPLVARQALETLLMMSCKVVMPSELESPSRSFASNIFSVSKWKKLLRSGTDGGKLGRKFFFNRGSSTKATATEGTVPYADHPVVAQVENVISPLLVSLVEQYAKSLVSIPEHWILLELSLQCLGTLIERALICHRPHTARALTSPLLPKILFQLILDTESNVTLEPSVRIDRVLLCETTLTLLTSCHRYLMLESLQLPEARRFFQLILEDATDEITTLLDDPFPRAVIATRSTQNRDKDHITSIAALQLFVLACPTVPSDAFGLKPKLVLPVHQWMWEDEMRHKNCMIEEQCVLLERSWARLDHHACIPLRLKSANVDLRTMTMWKGPNGVHRNIFRAYVPFVYHFADEAALRPIVAVKEAGPCAADGTMLVWKLTTSETHDRHAMASTIITKEVNSDTGSSSSTRRGRFKGSITSRTLSEKESTNASASVLPAVVLNTQLEVPEDHISLTEEYFTSLCIFAKNTSGQMAKQVATCACASMLQLMFLSGASERFEKLMTKAVLPMCEMCREALISADKATKALALTMIGWMLYHPMAEPCEFTGSALRCGLLAQLEILSKMALLVHERPTRTATLAEKANTLAGCIVEKIKNSRTSHIDGDAEVNVASNTTLDRAFFSAAMLRVQTVLDELQRCQCKAAKDPVATSSSSTTTTADKQGSSACVSKVELDTHESAIRELLRIFQESNDITAYEVFNAGVASTLLYYLLGDRTLEDVAGDTVVYASGAAASTFQSKTVSLQGVHMGLIDRNASSWAAMMASGMHVADILAMYMDEKRMQCFIQCAVAYPTGMRRLVSTLTSNLSLQSYLPLVESVVTYNKVVCKTPLQAHDALVMISPLITLCGDAGQRILAAIKNTTDDILPLPHSDNSVAADGFSSMPAASHPSRAEPKLRKPGLLSSSLARSKAILSRRNEPRNVTRIAKECCMEGHRLQFTESYRQAHFCNKCHRTIFSGHHCRTCNYNVCVNCYRGYTGNVELIRSLASIERNHVHLCATIGDLERWFRTGSTSTKGTQLAPASQSTLNHLERFTTRVLTFLKRYTEVRNTPAATPFTHASGATAPSFLSSASPTTSISFSVELAKKLLSHPNVVRRLTYKYLSQFSMRGVLLDEGAPIIPAHATALDAEVQKVLSTAVERQAAHYMVQEAVEERYILYRPSCGMLPFHETVLSTLYRRAFALGDYQLLLKLENCLLRLDGTVEEPLTLQANSAVTVANPAAVSSGRHLNMKFIKKSKSVKSPLAGGRTWSFSSSASITAGKPITASEEKLVEERELEGNSAVKNKTYIFHHFESDSAACCACGAHSRAEFHTEEPPALIFTAPDFAHRADMLLLIMLHRVLFEETHGLIAYAAEAKDIFGGDDSIFENSAITTALVRSLEASALRVSMLPPLYALPRWVNFVLREGRFLIPLSVRERTSRFLAYGARRSFTQHMRFFRNQRTNRPFLNLPGEWARQSNHKFSVSRDTFARDAYMMLRKCSDARFPISVEFKGDVGVGQGPTAQFYTLLATEVSKCCTKLWRVDGDKASNRTNTAAVTNSSLAVVARTDSLMAASPPTSLPRRTSSITPTHSPARASSIKNGAAGTVNSRSFGATYTPTSSAKISHAGSVDSAACSATLSPRPFMAGALDADAVLVPPPEGFYPRHMDGVRWYVEDVESFPTTPLRCCSSDRFLGDSVTARALHRSCSEQLGFSMTRRGLSFIDHASTWGTDKNHHHSNNLSASAAHHNVNKRTVLVDRNAGLMRGYAMEQRERAKAYYAIGAALGRVFVDEQVFPLSLSRAIVYFIRRGVPAYQSVLPMVKHTDPLPEFPIDLFELPLAAVSWADQRLAKSLASLSTMDKATLAALDLYFTLPGDDNFELFPGGAQVKVTKENLRLYQRRVVGAFLYESVAVPLYFLTMGFQDVVPHEALTALEVEELIGILCGEDKNPNDPLWTTDEIRSVLVGDHGYQNDSPQLGLLAKVLGQRLTPAEQRDFLLFCTGCPRLPIGGIRALGAITVVRSSNAFAEAHTEALQAEAGTSVGSSSGGAGLIHVEEGEEGEEGEVQSGPLGGLCKPSAQTNAEDTPSVQPESPRCNASSLYSTVSEQPCDMTSTFEADLADSEWALPSVNTCFRYLKLPPYPSEDLLYKKLLLSITQSGGNFELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SJV0</accession>
    <name>A0A088SJV0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_344680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702887.1">
        <property type="nucleotide sequence ID" value="XM_010704585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SJV0"/>
    <dbReference type="GeneID" id="22578973"/>
    <dbReference type="KEGG" id="lpan:LPMP_344680"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340054600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_344680"/>
    <dbReference type="eggNOG" id="ENOG502QW4T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276884at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO02087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="389" mass="44042" checksum="2B84793B4ACC31A2" modified="2014-11-26" version="1">MQNRVAFYKPLQRQPLSGRIGELMPMGSHPFTCFNPDTVRRMSSRYGVPVDDVVAALRDASGDVNVATELLEQRLDIEVGFGSYGLVCLESYAPETFCLVSYNLPTFASTQTDEVLDAIHELTLSAAELPLDTPHDRLLDKFLNHWTTEDDVPCGAMLRAYDMTVQHILLLPFGDYGVQGFHVLMPVKEGTPNIGVAAAACCMDLRTGIHNRFRFHVERIADSVSEHVVQEMLHYNQSAHLLRQPYWFRPEYSVEEFIRFKESLLQPSASIFEMRYAFLFAPQYGLPHYRNIVEMEKLKIAQHRYEKHYEDFTAPGKWLTSDNAQLQTVAASAGGSNVPGGAMHNHTNDPASIQTAMETRTGPLRRTLAQSMQAHGDRVFNRFYRNNAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4X0</accession>
    <name>A0AC62A4X0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Beta tubulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3320220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="XUY36730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="443" mass="49744" checksum="1E1DE6A6BC45CBBD" modified="2026-01-28" version="1">MREIVSCQAGQCGNQIGSKFWEVIADEHGVDPTGSYQGDSDLQLERMNVYFDESAGGRYVPRAVLMDLEPGTMDSVRAGPYGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELIDSVLDVCRKEAESCDCLQGFQLSHSLGGGTGSGMGTLLISKLREEYPDRIMMTFSVIPSPRVSDTVVEPYNTTLSVHQLVENSDESMCIDNEALYDICFRTLKLTTPTFGDLNHLVAAVMSGVTCCLRFPGQLNSDLRKLAVNLVPFPRLHFFMMGFAPLTSRGSQQYRGLSVAELTQQMFDAKNMMQAADPRHGRYLTASALFRGRMSTKEVDEQMLNVQNKNSSYFIEWIPNNIKSSICDIPPKGLKMSVTFIGNNTCIQEMFRRVGEQFTGMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATVEEEGEYDEEEEAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A544</accession>
    <name>A0AC62A544_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histone H2A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2120040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="XUY36874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="132" mass="14131" checksum="AA172C2797451F2B" modified="2026-01-28" version="1">MATPRSAKKASRKSGSRSTKAGLIFPVGRVGSLLRRGQYARRVSASGAVYMAAVVEYLTAELLELSVKAAAQSPKKPHRLTPRIMMTAVRHDEDLNSLLKHVTLARSGVVPSLHKAITKKKGGKKSKATPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5I2</accession>
    <name>A0AC62A5I2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phospholipid-transporting ATPase 1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1320260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="XUY36997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1096" mass="123957" checksum="D6496D00CBFD2199" modified="2026-01-28" version="1">MPDQGPWWRKCLPASIFPKVCSWACCSVMEADVDEDAEVIVYMNNPELNAQFNYPSNFICTSKYTLISFLPLCLLFQFKKVSNVYFLIHMIISFIPGLSPWSPATSAVPLLVVLIVALIKEGVEDAKRHTADKRANSIAALVVRNGELVSVKSKDIHPGDVMYIANGEEVRADVVMFATSLEEGQAFIDTCSLDGETSLKSRKAVEATWPLCKVETIMNSTAVLHTSLPDPGLLSWTGLLELNGEEHALSLNQFLYRGCVLRNTDWVWGMVIYAGIDTKLFRNLKEKPLKSSNLDRKLNYLIIAILIFQQVMLFIIASMAMWWNNRHRDHPYLFFFIEMHKGGRLWGYRYLTYFILLSYCVPISLFVTIEVCKVIQAQWMRVDCHMMEYMNNRWRHCLPNTSNLNEQLAMVRFIFTDKTGTLTENVMKFKRGEALGIPIESDRLDETITRLRKEEESKGLGQLQEYFLALALCNTVQPFEDEKADFGIVYEGTSPDEVALVQTAAAAGYRLTYRTTKTITILLRNNTQKVYNILATLEFTPERKIMSIVVEDSGTKKITLYSKGADSFIRSQLNRGPDVQEHMDNIDNTLTEMSLMGLRTLLVCARDITRQQLDPWLVNFTEAGKSLHNRSSTVDKVCLEMEKEMRLVGATAIEDKLQDEVPETLSFFLSAGVIIWMLTGDKRETAVTIAATSTLCDPRNDFIDHIDIGHTSPSDPKAIERVGRDLDVVEQHLALKGTHQERRCTLVIDGPALSIAMEHYFEQFLRVSQQVNSAICCRLTPIQKANVVSMFQRSTGMTTLAIGDGANDVSMIQEGRVGVGIIGLEGSQAALAADYAIPRFKHLRRLCAVHGRYSLFRNASCILVSFYKNITVSVVQFVFAFYSGFSGLTLFDGWVLAFYNVFLTSIPPFFMGIFEKDLPEDLLLERPKLYTPLSRGEYFNLVTLLRWLTESLTTAVILFYVAYPTLVRQDGAHQRYAGNEVGTIVFSGLILVILVRFALQIHYWQWIQALGIGLSAVLFMLLIIIYSLIPSAGGSTNFYFVAFDLMSTAKYWLYLLFYISAQLVVTLGVMAFQKLFFPTLQDVAEQQYAVQHGGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5Q1</accession>
    <name>A0AC62A5Q1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATG8/AUT7/APG8/PAZ2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ATG8B.2</name>
        <name evidence="1" type="ORF">LPMP_1920160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="XUY37137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="118" mass="12274" checksum="A4EBC961EE5BB0EB" modified="2026-01-28" version="1">MSAYQSSNTAEARRAECARLQAKYPGHVAMVVEAAKSSKAHLLALPRDATVAELEAAVRQALGISAAKVTLAVEGCTPAATAAVGDVADACKHADGFLYVSVRGEQAMGIFSLCFPFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5V4</accession>
    <name>A0AC62A5V4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATG8/AUT7/APG8/PAZ2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ATG8B.1</name>
        <name evidence="1" type="ORF">LPMP_1920110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="XUY37132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="127" mass="12834" checksum="EF18415DD8E68F1D" modified="2026-01-28" version="1">MSAYQSSNTAEARRAECARLQAKYPGHVAMVVEAAKSSKAHLLALPRDATVAELEAAVRQALGISAAKVTLAVEGCTPAATAAVGDVADACKHADGFLYVSVRGEQPMGALLAGFAGPCFASDSGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5Y4</accession>
    <name>A0AC62A5Y4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha tubulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1320200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="XUY36991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="451" mass="49683" checksum="3D47FCCC1FBC5BF5" modified="2026-01-28" version="1">MREAICIHIGQAGCQVGNACWELFCLEHGIQPDGSMPSDKCIGVEDDAFNTFFSETGAGKHVPRSLFLDLEPTVVDEVRTGTYRQLFNPEQLVSGKEDAANNYARGHYTIGKEIVDLALDRIRKLADNCTGLQGFMVFHAVGGGTGSGLGALLLERLSVDYGKKSKLGYTVYPSPQVSTAVVEPYNCVLSTHSLLEHTDVATMLDNEAIYDLTRRSLDIERPSYTNVNRLIGQVVSSLTASLRFDGALNVDLTEFQTNLVPYPRIHFVLTSYAPVVSAEKAYHEQLSVADITNSVFEPAGMLTKCDPRHGKYMSCCLMYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKCGINYQPPTVVPGGDLAKVQRAVCMIANSTAIAEVFARIDHKFDLMYSKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGAESADDAGEEDVEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A605</accession>
    <name>A0AC62A605_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histone H3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1620450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="XUY37056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="66" mass="7238" checksum="D87F239EB5F19D1A" modified="2026-01-28" version="1">MPCARCRACRRRGGPALPEQRDPGDPGGVRCVADGCHEPGQHPREACVTVRPKDVQLAVRLRGERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6C9</accession>
    <name>A0AC62A6C9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Folate/biopterin transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1020050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="XUY37358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="696" mass="75691" checksum="B8104E9EE0BAE9F6" modified="2026-01-28" version="1">MDPAENRKSHVTPDTEAAAAAVPVATVTENSGKYIHPEAASLFATCSWLRRVPIFGEAVEGYGPKVIVALGGCYLMCKGIADQILYGQTYAMMIDRYGIDVARYQRLSPISTMGWSIKAFTAMLCDGFAFLGYTKRWYMFVSCVAGGAFALIYGLLPAKESSANIACAFIFLSSWGKANVDILSQGHYSRLMRQNPQPGPAMVSWIWFWIMAGSLIGTIMNGPLADAGKPQISIFVSAALQLATCVFYVFNWYGEKKNRVLRSEDALYLLEETRRERARLGLEAGTDGQAGAAAKGKRSPQHSHSDEDVDAAVPGGLHDSRALVQDDYYDDDSEAVADGEAYYGKPPVPCLLGLFEVNTEVISKNWRIFVYSAVMTCAVIAMLCANILADTLGLLMACVVVSTICCATSFWALPLVIAKANVFGYLEKTVTIRVSSPINAFYLNSNHCPGNLPNFSYSFYNTVAGVITSVVGMITVALFNFLFAKHSYRLTFIVTTIMQVLAGVFDIIMVKRWNLYIGIPDHAMYLWGDAVVGELVYMLGFMPQIVLLSRLCPRGSESVVYALMAGFARLGRTTSASLGAILMEYALPVFKMQDDGSRCNFDNLPVLLFVCNMCTPLLAIPLSMALLPKARICDDIDVDGRVVRQIVDRQAAAAGLCDSDSEKVAAAESSRDGKRGDGGAGHTEGEQSVHVRTPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6J2</accession>
    <name>A0AC62A6J2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amastin-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0820210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="XUY37301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="173" mass="19055" checksum="CFF78EF5A502072F" modified="2026-01-28" version="1">MVFTLALLLYVIVQFIAFLFVLVGTPIDMFRPLNERRLGNTPCITLWGSKDECYSSRIDVSLEQLWVECPGRRSLFKTAQVFAIISICVYGIAAVLGFIALCCCSCLHWVCLALNLTGAITLCVVWASMVVVYEKADGPCVRDKDLSVLGSGFALLVIGWCLDIINIALLLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6P6</accession>
    <name>A0AC62A6P6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cathepsin L-like protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0820310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="XUY37311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="441" mass="47700" checksum="424694E83C60FE66" modified="2026-01-28" version="1">MAVPRVLLCVVAAVCVLLAAAGVPARAMYVGRPVSVLFEEFKQTYKRVYATLAEEQQRVANFQRNLELMREHQANNPHARFGITKFFDLSEAEFATRYLSGATHFAKAKKFASQHYRKVGADLSTAPAAVDWRQMGAVTPVKDQGACGSCWAFSAIGNIESQWYVTTHSLITLSEQELVSCDDVDEGCNGGLMLQAFDWLLNNKNGAVYTGASYPYVSGNGSVPECSESSELVVGAYIDGHVTIESNEDTMAAWLAVNGPIAIAVDASAFMSYTGGILTSCDGRQLNHGVLLVGYNMTGEVPYWLIKNSWGENWGEKGYVRVRKGTNECLIQEYPVSAQTSGSTTPGPTTTTKAPKGLVVVQTTCTDYFCSKGCKEKVFSTNQCYGSKGGKSVTMQCGMSEVLVRIYPSSDCSGTPEYKVIPEGKCMVSTSGSSKSICTFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RGY1</accession>
    <name>A0A088RGY1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_020320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009371">
        <property type="protein sequence ID" value="AIN95212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698177.1">
        <property type="nucleotide sequence ID" value="XM_010699875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RGY1"/>
    <dbReference type="GeneID" id="22571842"/>
    <dbReference type="KEGG" id="lpan:LPMP_020320"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_020320"/>
    <dbReference type="eggNOG" id="ENOG502QTT3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273797at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001838934" description="Integral membrane protein" evidence="3">
        <location>
            <begin position="48"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="732"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="765"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="901"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="926"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="974"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="418"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="981"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1014"/>
            <end position="1027"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN95212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1027" mass="109527" checksum="51B53026D94E70FB" modified="2014-11-26" version="1">MPEVPVKRRGCFRPGEGQWFRMSRRSAAMMAAVVLFLLVGPSPPVNAFNVCADISRCSECVFDQTDGLMPPPLMCGWCESTKTCKEVNSTVLSYYRSTLATGGVGGDGEAGAEHTAAEIAAFRTQFCEDFRERNFNAVCPDMFCSASQTTNNIYICRAPSIAALVFGCILFLLSILMYLWMRTIHQLPWKYEPFLSDFLAGRYRRPDSAVHGDDGDVAAVLGITPPSAKQKGHRAASPFCGRDSCANGFGKRDSAGGGEGASSSPAAPPPPPKLRSNARPPRAASSAASSAATSIVTAAATTGHCPLCKCRHPVPLGPGDVCFWCNVARFAFVPVSLALLSSSIVIVLTFAASLKPWFSDAYFAEVLIVAYLFCGGFVWYILRHRRCAPRFYLATEAAREAHSEVWSAAPCEQPNSQSPSAATSATSLTSGASATEEEEGGSTPSMQLLNDACRNMTRTTYLRLALRLRGRSLLDQLPELTMYRAQIEAMNAAPITLTRNGGVLTAMCAPRAAAAVVAGCSPRGGAAGLATTAAMDAAGVPMTTVLVISPVAEMTAASAVTAEGASIMAMTPTDEDTTPPPTAAAAAAPTASLPSSMSFPLQSARLMQHPTRPLLAATNATLESTDTVDSMGGYAFPSGVQETPAAAAAPVSAFATAAAGAAGAMPAAPLPTTATLPESVARQKRAETAQLLTSDSLSRQYRKALKATLFKDELIMWYSVPQLRGVLMENKWLLLGLLAGLLFGVWMLILSSVSDTTYAIVKLSGSTAVAACGLVVVLGFALLLIVVIRSCGRLYVLTNERLITVYESVTEPVVTATDLSSVRFAALYGYRTIWSGEPVLGFSWEVPASERKMPAIKSHKFAGITDLHEFIYYFRMVAPQMPYHLERISESTRQDRIEWRLYVILCIGVFVALPIITVYPHAVPDFLAAYLYVVALLFICSTLLRGLRTQQMTCAPLNLAASWASGSVWSEMDDVGPSRPLPSSVTHTPDAYSMQNTISSSMGNSEGPHDFSKLSASPPSLPIKQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RH70</accession>
    <name>A0A088RH70_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Vesicle transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_030870</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the SFT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP009372">
        <property type="protein sequence ID" value="AIN95322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701030.1">
        <property type="nucleotide sequence ID" value="XM_010702728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RH70"/>
    <dbReference type="GeneID" id="22571953"/>
    <dbReference type="KEGG" id="lpan:LPMP_030870"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_030013400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_030870"/>
    <dbReference type="eggNOG" id="KOG2887">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="73614at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011691">
        <property type="entry name" value="Vesicle_transpt_SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137:SF2">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN95322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="218" mass="24280" checksum="3B2343A590DCCF6C" modified="2014-11-26" version="1">MTTVDSGRQRNPGVLQDDGENKLGQYWSQLKYKALGLVSGEPLPDTALLTEMPPEQGYMEGLSEMTDLTYTQRITGFFMMMGMGILFILLSMVMWMWPKKFSFFMTCGNIFCLCSIMFLAGCAQQLRTMFEANRFEAACLYVISVFMTLLSALWLQSRLLCILFAVAQLASILWYALSFIPYARQTLKVALSYASLILGPVVNVIAKGVSSCLGAILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHA8</accession>
    <name>A0A088RHA8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_030240</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eL38 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009372">
        <property type="protein sequence ID" value="AIN95258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700966.1">
        <property type="nucleotide sequence ID" value="XM_010702664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHA8"/>
    <dbReference type="GeneID" id="22571890"/>
    <dbReference type="KEGG" id="lpan:LPMP_030240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_030007200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_030240"/>
    <dbReference type="eggNOG" id="KOG3499">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268647at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022618">
        <property type="term" value="P:protein-RNA complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.90:FF:000002">
        <property type="entry name" value="60S ribosomal proteins L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002675">
        <property type="entry name" value="Ribosomal_eL38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038464">
        <property type="entry name" value="Ribosomal_eL38_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01781">
        <property type="entry name" value="Ribosomal_L38e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN95258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="83" mass="9487" checksum="2EF93F2F2829F81A" modified="2014-11-26" version="1">MPREIKTLKEFLAICSRKDARCVKVKRNPSATKFKVRCSRYLYTLVVNDKKKADKIERSIHPSVKKIAVTARSHAKTNAGTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHZ2</accession>
    <name>A0A088RHZ2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_060210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703904.1">
        <property type="nucleotide sequence ID" value="XM_010705602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHZ2"/>
    <dbReference type="GeneID" id="22572227"/>
    <dbReference type="KEGG" id="lpan:LPMP_060210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060007600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_060210"/>
    <dbReference type="eggNOG" id="ENOG502SA81">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266425at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="212" mass="22398" checksum="90A17F58049E8C27" modified="2014-11-26" version="1">MGVILNLSVYGLMIIPLVAMVKAHNLSLRKLSKLSIMMAAVQLAQSTIAMAVPPDMMGVQVSVQGALLPLVTVVFCFFTLNDTKAVKVMHLHDCGDGDVGAAVATLWCLCYTVLFRWFPWYHSLASRGFEAANLVSGAEAYLTLVTMLAMCRSFTTGSLTAAMAAWVLHVVGALAGAVAGLPVVGTALTAALMTAVSATVFCAPAERKKMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIM6</accession>
    <name>A0A088RIM6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nucleoside triphosphate hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_070620</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Clp1 family. NOL9/GRC3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP009376">
        <property type="protein sequence ID" value="AIN95748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704070.1">
        <property type="nucleotide sequence ID" value="XM_010705768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIM6"/>
    <dbReference type="GeneID" id="22572397"/>
    <dbReference type="KEGG" id="lpan:LPMP_070620"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_070011400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_070620"/>
    <dbReference type="eggNOG" id="KOG2750">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2405412at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000448">
        <property type="term" value="P:cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003277">
        <property type="entry name" value="Molybdopterin guanine dinucleotide synthesis protein B, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF3">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-HYDROXYL-KINASE NOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Clp1 P-loop" evidence="7">
        <location>
            <begin position="688"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="104"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="201"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="252"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="861"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="907"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="274"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="305"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN95748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1201" mass="128264" checksum="7C6D46B87B1E3A21" modified="2014-11-26" version="1">MSAPPASLSRAPDSPTVASELTFASQEGLPTALAVSDAAVSTTVAAHTMASSSHAQVDSKERLLLRRQQKPVVFSRQWRRHLFNATASSSLPLTSSKPIASSTVEDALQGHRQSIGRRTHGCVSESGADRVSNEEDDDNEDGASPFGNASIIKLSRTEDREGVPGRLPAVPPSSESDDGENRLSLESSSTMHATAVEALEGSHNGVTLQSSGAPTRRQRHQLRQRAQEEREHHRVRRHMAGYDPDFLSRQESQLHVNKKCGSSEESEAEDEGSGEYSSEETAYSASSTAESESLTSLSEAGGDEKAEEAEEDGDTNDDLLGSSAPAPHEGHTVVSGGGLCAAERTEHERHQHAQYKGSTVTPPPLIGDAHNGGSGTVSTSARSLFFQSFFFACHEIRLHPSGCHHTLVGLQDSVTIKGPCGIIGFGLGEVSVSGFYLGRKQLTLWHEEHRAVLMPMKRLKTRHAQDMELPQWPRVPAPAWPPGGLSTAAAAEPSRRTDVGDVLGHPLNPLYYRGVCAASGIRKSAVLIGVSAVTAAPGTGEPDEEEEEAFLQSLQWGCESVFGEVDWDWVEATVQSWRSLFSNQLPPILLILQPPSSLRRHADEGPTRRFYLTRKRGRQYGTASGKAERNTKGGGALQDAAAAAPSSAYMDIPSFVAHRSEPSVDLALVPSIVPSIAAQGCGSVMVLGSANIGKSTLCRYLANTLLSQHGLCYWLDLDVGQPEFGVPGQLTLSVLRRPLLRAHDASCAQVVSAFFVGGSTAAQCPLTAANALAAVCAQAREVSKAHPVVVNTHGWVLQTGRRISVEALRRLRPRQVIHLYKAQEELWAQDTAALLDPRNGLNAEVVQRRFLVRHRNASSAAAAVGGERADKPAAGSKKRKIKGAPPSSTAPSALLLCRLPYPYTHEEAVQQAGSSDRESPVSPPTTAKAHKWCGQVHSVRVQREDTYSSIARIKAMKGSRGRQQRWETYFSALFRHYVGSTTSGAKAASKDSSPVEDEAETTLLEAPLSALHSIVLAERDEKLGDVHLAGPALPSSSSAEVTSPVTASVAAQQRQTRQTHAEVAAALEHAVVAVLFHARPSAAAAHGQSNGGERWCVVRSLASLQNGFPVSCYGVVESCEQELLHGVDAAQYENGASSSGGDSALAGWIRVRVPLRPSVVAAMLSIPEAGLADVTAKWSTNVSIAYSAALRSDTAFADTWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIR4</accession>
    <name>A0A088RIR4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_080740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="AIN95882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704204.1">
        <property type="nucleotide sequence ID" value="XM_010705902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIR4"/>
    <dbReference type="GeneID" id="22572536"/>
    <dbReference type="KEGG" id="lpan:LPMP_080740"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000034000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_080740"/>
    <dbReference type="eggNOG" id="KOG2084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5945798at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF292">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="505" mass="54234" checksum="6967F69A87211854" modified="2014-11-26" version="1">MSCHVHPTQVSIGAAPRMAVQEMHPDAKRKGRRVVATMDLKPGNAIFAAPPDIAVLYSPFASHICARCLVADVRACAEPHKAHHHHPHQQQRVTLSRSPIGAPSSLSSSSSSTHATAASPVRSYCCPNCDQFVLCAPCVVQLLLDIGVDVMSSAGTDAINTTATVLQRRGEGKRGISVVDERLTLHPLLCAHAISCAWYTSLPASIRAPGNDTDFLRFCLDYGARAHLGDTAMMRALATLDTNASVQSRESMQLCEVFARDRVVATFGKGPKVTPTALATAGSAKHMGGDSLSNQADAHASMNSIHRGGDSDGPRYRGSSTGDPFPPRYPIAWTDLRDILLRTRCNSIGFPYNTEETTGWSLHETVCMLNHSCVPNAAVVMLYDSADAMAATAALAARTGAPHSALPEGRTEEAARRKASERIAAFRAVATSSESPHSTSYSPSLAGWIGIEATRPIAAGEEITISYVDLGSFGDDLQTRSRHLLEQYRFLCTCDLCMRQRSQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJG0</accession>
    <name>A0A088RJG0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_100480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696770.1">
        <property type="nucleotide sequence ID" value="XM_010698468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJG0"/>
    <dbReference type="GeneID" id="22572784"/>
    <dbReference type="KEGG" id="lpan:LPMP_100480"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100011000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_100480"/>
    <dbReference type="eggNOG" id="ENOG502S7YD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="247900at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="797"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="911" mass="97946" checksum="9E6B477D30AAEC76" modified="2014-11-26" version="1">MLRIVLQRLAVQHRIAQQLEAVSLDEVLRRMQSSSLTNPSRSLEAHFVLATEGRGHEPNTPAATSSGAENLKESSGDLLRNALSERLLAEVHRELGSPTITLDDASLMLANCLRHGLSPFATQQIFTLWQRRMHHAVAGAPSAASSRTSISMLGMGKGNTAVAHASGGAAGVSELAQFQSLVRVMEACLDAHDRQQQDLSRSLKRISLAAPGARKLRSKSSIVFTLDDLAALVDTVEQHWTLFIDHGTSTTGLLVQFTALALVLTGCASSAAAEAEPGSRFVNSLRRLSHLRTDRALLQQRIFCLCDQAIALLCSQEEEASAAGDGNTPSRRESPWWYRPQELVRLSQAIQLIELYEAEQRRGSGTGSPVEHSFHGEGGGPRRPGSSAARTLRRDSGKMALRSSNPVRGPALSGAQTARAPSMAHCLLHLPTAWWPTSSASLHEAAAGHRTTAAAVRARRRLGVYVTHRALQHTSTAMSRLSAPPPPPPPIPSYAVSPALVSISLADIGEIFATVCATASSLASTEAVTGFSWWVRDVFVQQYRQRSLHDVQEIAALLGIAEVCVLYPDGTQTVLAEALKCLQRSAPVLWRVGDTAVTSGPDTPGLLWSRACEVVGGALTLATLRAEAQRTLRALVHTASQPASSSIMARGSSSELACRHQRYGLLVLACLQLQSPGGTITPALKRVIQELVFSAPFRCDDADHGGLAAVARALFIFTRPELTLRAPAFAQDTPLCDPAVPYLLNELTRFLSSSAATWGDGATVVVEDDKDNLQPLPQLTSVERQLLRTALHEVQLQTQHDVKERTPRGHVVAPSGGEVGQGQAARTASVQVPLSLSVTTQAGVVDSADASMLFSDRQAGAVNTKSGASRRCIVSHERAPRRRMSSSKEHLVIQSEIDSLTHYLRQRLSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RK89</accession>
    <name>A0A088RK89_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_060180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703901.1">
        <property type="nucleotide sequence ID" value="XM_010705599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RK89"/>
    <dbReference type="GeneID" id="22572224"/>
    <dbReference type="KEGG" id="lpan:LPMP_060180"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060007100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_060180"/>
    <dbReference type="eggNOG" id="ENOG502SH0Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="252791at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057317">
        <property type="entry name" value="PH-like_tryp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23732">
        <property type="entry name" value="PH_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH-like" evidence="2">
        <location>
            <begin position="390"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="492" mass="52689" checksum="7CDF8F9AE734982E" modified="2014-11-26" version="1">MAPRTGPRVKVISPNSESAIMSRSISVDSSVYSSGHATPGTASLLRSGFRHGEPKRGDDDVAYSGRRAATGVALQSRRTVLRAMDVNAVHETGPFHGKSSPYDRAPSSAQAAARSTATASGSSGNDGKCGHTRRSLPNFFEEADFGNGSATERRKRRVDVSISRSHTRSYLVDASAVGQWQQPPSCQQAENEGAVRRATAALEHAGGAVLRRPFCGSNATSNRSRVATSALGGNTSLLPVQQQPCQSERRGLCLPPTIPITAHTRCYRSEDSDYSGNNTSMGSTASSNKRARPWAEPTPSQAASQQPTSACRSSFYGTQPMAESATQRPAVPRVCPGMFAGLSAIPVDERLFADAVGLHTNVISTAFAVPSARAAATADGGGSAVQQRYCVCPLWSLVGTFKTSLSSLVTVDFNQECLRWSQRNPKGGQQTIKVPLASVLDVFTTRVVQEDEHIEERQFTVVVRTSTRPSQVVFGFARVAEANRLRNVFKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKY7</accession>
    <name>A0A088RKY7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate dehydrogenase assembly factor 3</fullName>
            <shortName evidence="6">SDH assembly factor 3</shortName>
            <shortName evidence="6">SDHAF3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_130710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the complex I LYR family. SDHAF3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697153.1">
        <property type="nucleotide sequence ID" value="XM_010698851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKY7"/>
    <dbReference type="GeneID" id="22573181"/>
    <dbReference type="KEGG" id="lpan:LPMP_130710"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130011400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_130710"/>
    <dbReference type="eggNOG" id="ENOG502S8MP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="278329at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006105">
        <property type="term" value="P:succinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008381">
        <property type="entry name" value="SDHAF3/Sdh7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137">
        <property type="entry name" value="DC11 ACN9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137:SF6">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN96500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="252" mass="27412" checksum="295F2692589F3428" modified="2014-11-26" version="1">MGGDVGNDGINADVAACSIGYGPFSATVKTRRAREKAHKDVETPETAAAGASATVMNNVGLATNLHLRLSLAGLPHPSQLDDWPYASPEWRLAFVRLYRTILRLHNKVVAVSLCTTRGQGPEAALSAATGVQATSQTTAASAAATATESGHNLAEDKDDHLLRYLLTSDQREFGNRFVQGEFTRHMDADAVAATIFYASWHDYVLQLASGVTAREMTEKEKRLLSDEQKETLNSLRGAFFDLRTSREPKYMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RL74</accession>
    <name>A0A088RL74_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_150550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697430.1">
        <property type="nucleotide sequence ID" value="XM_010699128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RL74"/>
    <dbReference type="GeneID" id="22573475"/>
    <dbReference type="KEGG" id="lpan:LPMP_150550"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150010700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_150550"/>
    <dbReference type="eggNOG" id="ENOG502T81M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10258312at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038929">
        <property type="entry name" value="CCDC13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31935">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31935:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="76"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="335"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="609" mass="65122" checksum="786F586B914AEB15" modified="2014-11-26" version="1">MSFASSHTSPSTTASPEVLLTAYKAEVQQLRDDPHKVTPSDMEGCRSSTRGDTGPAARGVFGEALEGKYLLLIRKNKDLTVQLGTVQQQLAAAQKALQAEQEKTQRLASAVTVSSLGTRGVKSSSKLPAGATGLDDGGSSNSGNKTNGGSGGGVAAASSTAIARVYDQLHQKELAMAEVQRENATLRSLIQREVGLRDDTREVDDLLRRAAAASSSGGSTPAGVGCKSPSGTDAGGWRGRAEEIVLLKCKLKDVQRELKMVVAQSGSGRGEDGVDTLMDPLALPASVRAFLGVDADPATEARSIATTTTSQVRRPRRDVDSYARDRLSAMQHQRAAQQRELSANLEQQQHELNEERMKSSALQARVKTMKSELHTLRSYVDTILEKSSTDDELVAAYKTELQRANEEIRHWRRAAEETLKGASRGCNSDGETSTAFTVKGMRSGLNNAAAAAARAASYRQATEDKTIVSAGCGEEGKACAAPLPLWSSQSPKSFSRSLYEWVCQACDEVPQEVEPKSTQPAVEVSAKQLAAVLRHAYQHVVLVERSTVAAADMALAVPTSTSGESILHRENTALKRRVCALSDLMEKELQAQRVLWTIANADATPSTMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RL75</accession>
    <name>A0A088RL75_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_140570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697291.1">
        <property type="nucleotide sequence ID" value="XM_010698989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RL75"/>
    <dbReference type="GeneID" id="22573324"/>
    <dbReference type="KEGG" id="lpan:LPMP_140570"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140010900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_140570"/>
    <dbReference type="eggNOG" id="ENOG502S6D4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277888at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN96638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="126" mass="14801" checksum="4E75DF206BA0730C" modified="2014-11-26" version="1">MSLSTSPVQLQLCRTPFVLGVGGKWWKEGPPDYTRANRRRMELEQQRIVSSQHLPPIEPTAEQACQLYRRLLKEGYKTLVVTDKDFYRRKVRYELEVTSRQTSSRVRGIMFEKGRWMLENKLGGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLL4</accession>
    <name>A0A088RLL4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_160780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN96952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697605.1">
        <property type="nucleotide sequence ID" value="XM_010699303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLL4"/>
    <dbReference type="GeneID" id="22573656"/>
    <dbReference type="KEGG" id="lpan:LPMP_160780"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160012000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_160780"/>
    <dbReference type="eggNOG" id="ENOG502QQNZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2016285at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004766">
        <property type="term" value="F:spermidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000561">
        <property type="entry name" value="Hypothetical_protein_-_conserved"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558:SF11">
        <property type="entry name" value="SPERMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558">
        <property type="entry name" value="SPERMIDINE/SPERMINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="599" mass="66437" checksum="431973490F737EA3" modified="2014-11-26" version="1">MPPLSGQFLVGQSPRRPYINRASKFFFAQLDKGFASPYVLVASGVFFSYLAWRVMEHYVRPRQEHLAQRLPVQRVPFEASHNVFWGLANPDEAGVSTTGSRGDDVEDIASNLFLPQLANERMEEAMRRPQLLFSEMSELHEQPSATNPSGEVDIVCLELSEFSPKLRDDVYYRSVHYVPAQGGSAVASSTGHQVSSLTGSKQTSSSRSDSSQKLMVRSDKVAEAPAAAAAASDSPLTTAEAGKAASTTDYLQFMPGQGEEVIHGIIKCKAVTTQNNCVPYAGHLEEEYARKLMLTLGPVHILRDATQTLLPRRFSFVKQVPVETLVLGMHSGELPRWLSTCYPNFNVHVVERDGTLVRLCRRFLGFQESSNLTVHIDDPVEYVRRQVAMRAHGNTTVAGVKPYELVLIDAIDGAGRLSTQYGRLEFISNIRRIMSDNGCIAVTLPNKDAEFVFNMVQNWRMGFTGRPVVLVHCVTSPCSILLTFQDTAARGKARIGSIAKVEEFQDVLREHIRHYGADRVQFDITREVSAGNFSVLNPEQAYGMEAYLPAGHPAILAARHQDVQEAVLRQRRSQGWGAWLRRLTGTALSPSQRSDLNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLP4</accession>
    <name>A0A088RLP4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Small EDRK-rich factor-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_100400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696762.1">
        <property type="nucleotide sequence ID" value="XM_010698460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLP4"/>
    <dbReference type="GeneID" id="22572776"/>
    <dbReference type="KEGG" id="lpan:LPMP_100400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100009600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_100400"/>
    <dbReference type="eggNOG" id="ENOG502R25K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="370932at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1050.10">
        <property type="entry name" value="At2g23090-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039713">
        <property type="entry name" value="At2g23090-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007513">
        <property type="entry name" value="SERF-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026939">
        <property type="entry name" value="ZNF706/At2g23090_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33788">
        <property type="entry name" value="OS07G0114300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33788:SF1">
        <property type="entry name" value="ZINC-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04419">
        <property type="entry name" value="SERF-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118359">
        <property type="entry name" value="Expressed protein At2g23090/F21P24.15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small EDRK-rich factor-like N-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="83" mass="9582" checksum="C921964EBE0A1725" modified="2014-11-26" version="1">MPSGNGCRANQRRERELKKSQSAGVKHTSEEMKKHEQSKNAIQCTVCLQGFPRTVRRPELDQHIERHTKTGKSFEEIFPQFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLT1</accession>
    <name>A0A088RLT1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">asparaginase</fullName>
            <ecNumber evidence="2">3.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_150420</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-asparagine + H2O = L-aspartate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21016"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="EC" id="3.5.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparaginase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.1" evidence="2"/>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697418.1">
        <property type="nucleotide sequence ID" value="XM_010699116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLT1"/>
    <dbReference type="GeneID" id="22573458"/>
    <dbReference type="KEGG" id="lpan:LPMP_150420"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150009300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_150420"/>
    <dbReference type="eggNOG" id="KOG0503">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="427002at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009066">
        <property type="term" value="P:aspartate family amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08963">
        <property type="entry name" value="L-asparaginase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1170:FF:000001">
        <property type="entry name" value="L-asparaginase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="entry name" value="L-asparaginase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027475">
        <property type="entry name" value="Asparaginase/glutaminase_AS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041725">
        <property type="entry name" value="L-asparaginase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707:SF28">
        <property type="entry name" value="60 KDA LYSOPHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500176">
        <property type="entry name" value="L_ASNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00057">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00917">
        <property type="entry name" value="ASN_GLN_ASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="L-asparaginase N-terminal" evidence="7">
        <location>
            <begin position="20"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="active site" description="O-isoaspartyl threonine intermediate" evidence="4">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="108"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00049366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN96765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="390" mass="42381" checksum="02FF6D543E0C8679" modified="2014-11-26" version="1">MSVASAMPLSFPRSVAGTRRILVLYLGGTIGMKKNAEGALEPAAGYLTEEMRKMPELRESTEIAPFDIIEYDELLDSSDMGAANYCRIAADLQVHCDAYDGFLIAHGTDTMHYTASALSFLLCNLDKPVIVTGAMVPLAEPYNDARRNVVISMMLASNPKICEVCIFFNDSLLRGNRCDKVHHTYGAFRSLNYPPLGVVEATQFVLKEEHLLPQPMGAMKIMSDMRGRVGCYLIDPEADVDTLITLLEQKRPRSSLGTHTITAASSMDDGGDDTLQPLLDAVLLSLNGVGSVKGVVAQQLQRIAAVAHKCNIVVCAVDRDISGTLNPSEVQRLQAISPDIVYLNDMCIAAAEVKLMYLFGKGLSPAKVADAMTQNIRGEITPLFQAHARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLW3</accession>
    <name>A0A088RLW3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein phosphatase 2A regulatory subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_150930</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697468.1">
        <property type="nucleotide sequence ID" value="XM_010699166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLW3"/>
    <dbReference type="GeneID" id="22573513"/>
    <dbReference type="KEGG" id="lpan:LPMP_150930"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150014400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_150930"/>
    <dbReference type="eggNOG" id="KOG0211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="340346at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051023">
        <property type="entry name" value="PP2A_Regulatory_Subunit_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648:SF23">
        <property type="entry name" value="PHOSPHATASE 2A REGULATORY SUBUNIT, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="438"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="50"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="163"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="631"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="638"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN96815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="922" mass="98888" checksum="4D3E5DCDB1951AE8" modified="2014-11-26" version="1">MSHEDSNRDDWGVGTTSTPVAVPPLSSLSAHSSTARNGQELRMLFNVSSASTAARVVSPPTSSQQPPRRCSDSETANYRTTSPSPPPSPSQSSTTDTVSDSSDTLNEDTVTSSTELTRLPRALASSPSTPSPSVAPCPNPELSTQPLGAANLGSASAVGVNASLNGVPGGENRGSSSPTTSPNSPVVSGNPRRSLNAAFTLSPRTESEVEISVEYNSDASSVCFDLDRHDPPIRQHYHLGRLEERRAFVTEGCVAAAQGMSTQRILDHLLPALLTAFEADDYSESFEDCAPCIARALPQIVACMEARTTANLTYFMGLIMALCCSAEGVVAKAITTSLQTILEMLADDVLRELFLPFVLTMRLSFWSAPRVVAAGLLGYLAMRPAVLQASGLSVSDMFNYYAECSSDASAMVRSAVVMSLHDWVRVAAVHRLTLAEMPLPLLKSLATDDLSDTVRYLLIEEVVKLAQMIGPKSSSKYLLSTFVGAHMDPSWRVRYTAANQLGAMAALVMNANDLEVVLDTLARDEEPETRAAVARQLEWMVQHCSSEVIQHCCVPVAVALSQDADPVVRRSAARHYHCFITGSDEVVRTMCKALRALMQDAAFPVQENAIESLGDLVTALEGSLQAAVQPAALGSPGGSNSETALSSPNSFRSPASRRHPASALATAHARGSRHKSPHCSPRLASGATAGSGPADAGEVNATFTRKRADAIVRSFMTEVLTLSESRNWRIRDAVVRVVHHFCKVLSPGQFRPLTNMLFIALHDPVSTVRSQAVRTLKEVAVAYGGKWATQTAAELLQSDTLAPARAVSYMWRIIMIQCLEVLLPVASELGPCEAQRRQLLATTLPLLRDYVTDRVPNVRLAAAHALPCWYSWFDVTAGERRAYNAAIEELQQDTDIDVLSASHNIPYNNSGSSSSVADGAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RM38</accession>
    <name>A0A088RM38_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_161230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN96998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697651.1">
        <property type="nucleotide sequence ID" value="XM_010699349.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22573702"/>
    <dbReference type="KEGG" id="lpan:LPMP_161230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160017600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_161230"/>
    <dbReference type="eggNOG" id="ENOG502S4Q0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273568at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="677"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="849"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1073"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1178"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1332"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1422"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2092"/>
            <end position="2177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2216"/>
            <end position="2252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="681"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="851"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1074"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1095"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1137"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1187"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1240"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1275"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1288"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1335"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1436"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2134"/>
            <end position="2155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2216"/>
            <end position="2225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2252" mass="241345" checksum="7587B3C6B6A1D372" modified="2014-11-26" version="1">MGCKASTVRNSESSHDSRTASPGVSSSPNTNASTRYMPKNLTSTSPYRSNRKEDNGEANGSYTRDGGLSHTQYVDAQDDDPFATLSQEMVNQSDSDLTRCVFPTGKRWGDMPGLPCHSLDPAFPRVAEDVVRGNDHTAVAHQRKGTAESHFDPLPIPNVAQLQECAGTRVANSSLPSRTITVDSRDCSAIFRAGIDVHDKTDSVQAAKEYQQHVQARRSTEAAHTKRRQLEEFDPVRPVDSFNVTHRGLLGRCWDRRAPELALISFAYAMEAALQAAEETHLGRTTTSPPPGAETERDEHPFASPRVPLTPLSHTTGHLPGVAGSRGPSQAMPGSPRGCSLGGRRVPRRSHWFSVSCDTTYPPAKGSDLGNEAGMTVSSFYMSSGVASPIMTWPCPSGSRLPLSASLPALNWAGIAPLRSKSKPFMATEASSPVIYGGTTEGLSDEEDGGTAQPRQPLTPEQISALSMEKRGQYYNDFLARDPRFMGIKDCFAFRLADGVGEDPSTKFLRKRNLEPAPGVVARQWNRVEFVHPTLHTLIRAVAMTHGMTLNASQLEMLQRQAGGAMAEMPSRASFSQYLLSHTENRSFSRGGGSLNTSFLSQPDKPQSTSDTPGSYTNNSLLSPPRSYNHHPGKSGRSKADLFAATRFPEDSILSLALGIPRSRLPQLMGASLPPQLGTVSRSNSSPALAAAPNVSRDGDGGPAAYPGLSGTPHGSFACAGSDGSVLVALSVSSFSVSIDPLRWQENCYIRYPVNMNASNKASRHACGEGIVTDIMYGGVMFVEASSATAAKELQTLLASMTWTEGRTLDGVVGDVRKHLIALHGNRSKLRQATAPPRRTTAETETAFDAGTQTRHGSGVQQQQQQQAEEEKSHQYRICRRIGGRPMRDAVELQEISYFFDDFEVREECVTLSLPIQPVDATAARGAAVGPGGSTDRPAIFESRHTCNGSSLVADPDVSRPFSCVASVWVKLPVIAAVLRTWGLHLLSNPEFAQPTALFLQRYAGIAPALQPTVLGSFCNDGDTPSEEVDDDVDYLFFESGDASFTAPPAAADEATHPQPAPRIPEFNRFYASMPSTSSSTTGDPHASHPSTEARVQRRQSEDRDVPHVSCSPAKMHKSSSTALDVHDASGAVAEKQSLKKPSEETHDSLGLKNHSQDTLKDEAMHLADSVNSCWTVPGGTSGGGRQHSSVSSSIDTQDNKHVVARPSGAARESSKRTLRTSRCRSGSNKAGRKRAANLRSVSTYPVTQCNSPHSPGTGTRPQSRRNDPDGERGSQSSASSCSSPSSPTVTKEGTNDYQGNLSSLLTSCCNTPCLHGNPSPQSAYQKLLGKRLRGSTGAPSPSSPAESGKKAIVSHVPTTPLLTEAGRFAMPLSLRALNAEEELAPIAVTRAESSPMATTVSPASTATAVASGKAAGRHVSKVSLYSSHSPKEPQTCLTTANSSGNNGSAETPSAHAGKTTVTPSTELKTVARAAVKVPAKRLPPRKGGRVATRARTTATLTATTTKGVTSAEPPVIMTTKLKGAMTTSTRGKVARAGKMEPVLVKQAQTSVTHSVATVEPAYQLLLSPVTSLSTREIVVNSAKASSGLHATEDEEEELWRMVMLEVKAQQQELEDLRQACRDAEDVGKQRQDMLRLLNRILLPHTSPQELDCVLLYLRTALYEPEDIPHGRLFLPQPSWLPMLAAIWTAPANRIRTVEIAAELTWLDIPRLGLVAGLLYHQYASGPLEELIIRADKLLGSPQETAMLPKNYSSDADLVDDTAVRPKKFRLLTGRFRKSRRSTGKGNSAGVDRSSNSTLHFTTELDQVTSGFPPGCPPFIITPEEARDTLWLLLCSVAANTTAPTFRMVLRGLPAGEVSGAGRVRHHAKARTPSTRLASLFSGAAARFRHEDGDTQLLLKSRSMLLDNFVVCPGSPLLTGRDAHSHVRQSDSSGVGANVTHNSTAYDEGQLCYTNGSVRLDEDETAASSSISAQRTGNVSLQNSPVLAMSLTTATMGGIGEAACLPDQHGCDPNNTFTAVRPIVTPTQCTGEMSAGVVNGGGSDGFIRAVEAVQTHQHSVQLHRAWMRNGNCVEERPFYQLLVHRRGAAEGTTAAAQNDPNGAASKPTLWSAYPNIPCHHPPHSGTRFDGEPDGQQSLQEAVSQSATLATATSEAPSQQRQSSPSPSPPHHFPCSDFVHGLRTAADEQVALQSEAAALRERAGDIWEALRKSVKHHNELQMETHQKTMKRNGGSGSPSSPPPPPVRQIVLEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMD9</accession>
    <name>A0A088RMD9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_120460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009381">
        <property type="protein sequence ID" value="AIN96374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697027.1">
        <property type="nucleotide sequence ID" value="XM_010698725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMD9"/>
    <dbReference type="GeneID" id="22573052"/>
    <dbReference type="KEGG" id="lpan:LPMP_120460"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_120009500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_120460"/>
    <dbReference type="eggNOG" id="ENOG502SIET">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266856at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="615"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="689"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="761"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="852"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="938"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="143"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="692"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="874"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="975" mass="103944" checksum="CCE1043B4727B39B" modified="2014-11-26" version="1">MRDRATLKSSSQQGANWGHGSSAEGRDSEDDQLAQSPLRTLASLPQRTQELCEDLITLDSLVEADEAFFSAQEGMEGHVMELLRSWREPGSASDSRGGSRRPSGVYPLAAASHPSAAGAQLGDAVASCGSSGTQRVLHDFDEARDRIALLAKLHEELSELEEQHRGLQRRYVVEKSALSALNELCARLDEEDEAVREDGDGACYVEAAERVGRGAHRDGRSKTQEQQECDVVRAGLAACRLLADQLRSRGMMIADRLTNELLCLRSEVVRHDWAALQSSTPLTRMDRVAPLDGRDDSPISITSASRFAPLLQPAGGAAAGRGGKESADIADSDDAYHFSEVAGGAHDDEANESDHFRVTATALEATKSVVFRVHVPVFASATPPALVASLPDAMTTATGGAAVAATSCTPRVSGDGPRPASSAERMRGRSSGAAEALSIASTTTVSVIASPARYALVQLYECCREGLAAMLTRLCTLRARRTTEVERLQQDQSAMDVYDPAADDLADRCAALLRYVAQLDEWVGEVLRMDQVLHERVKLPLDAALQSYDQLRTLLLEVLKQRLEDEEGRGKEHVAAVVDAEEEGGEVDGRGAHYLPHERVCSGDKEGLHALQVEDGEEDGGDQHRMSGSVGDSRARGATLSLAKASSDAAPRPVLPRASAEFIGVLEALLQDQKAAGRPIATAAVFTGDTSGGERELDTGEHSSKDGVLSKVSPALAQRLSTAEEEHNVGTSALVGVEATAEAEPVSAQSATHWPRATATVVSGKANASEATGIRCDRQSEGVGGGHLAGRRRQRDPSEDESEVTPHSAPFYTPEPTDTDALDPTSTSAPPYEITVYVSSTSCSELGEELMEEMAMEQSVSHTQEGMHGLSKRLGHERDDSDGGKEDSDSDSSADSQRGREGNSNPEPQRQRYGLGSGNGLGEGLRALFSSVVRRAVSFGDSDDDADETGRTTSFQGREQGGKSPTPLHKRARCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RN14</accession>
    <name>A0A088RN14_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_191000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698095.1">
        <property type="nucleotide sequence ID" value="XM_010699793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RN14"/>
    <dbReference type="GeneID" id="22574154"/>
    <dbReference type="KEGG" id="lpan:LPMP_191000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190017100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_191000"/>
    <dbReference type="eggNOG" id="ENOG502SM4Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266601at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="753" mass="80740" checksum="5B7FFD583517A1CA" modified="2014-11-26" version="1">MELQTQQHFCLPCPRPYTTSLVWMCLACGELAPYEGASYYSTNNDHAMSGGFDLTTALGDREAAAYAYSSSPPESTPQRYSHLPCGRAESSYRASHYTSSSSSSSGVAAPATATTTILASSLPTLTPLRQAQQHSCVNDASDSYLSQAASSNNRQQHEQQLPLSVMRRITSATVEDVIHRNSVGSVGERRKRCEGALFSAEVFDLRAGEEAFGNDEVSAGGSNLSSRCQRAPTDVTAPDTPQLATPLGNIRDDGNVPAATPRAPAAVSLPQPSAACPAPWRDADFNDAQSLSSAGARSGQQEEDVTCSLTALLAEEYLIGSREMRFCCCCGEVRCAEIRKVTELLPARATVSASYGDAESDEPLDFSVPAAESVFQPSEAAQWRSPPPQTSPADRQQQTQPRQSAESNSRKEISSVHLVALSLARLLLKVKAIAVAAVYNLHPLSPALPKAYFRRHGNGDNGETAVGDDEKSVSTSDSAPLSVNSISRPPPLAPEGRRLRYPLQGPREMDTNRATPLAYVPAEMHPLPCLASVFSVTGGGTVEDLNSVSLDSSELPSWAFTAPDEEDTYRAEEADESLVIQNLRGGVQSDEDVGTRSAEDAHACVRRLHDGSLSLSAIAGTTAATRVAREQKEKWNSISVSEALWRLVLPSLSAPFLPTTSKPSTAAADRAFSLDGRKPLERLMDWIVFPPRRGAVESTASSAVVTSARPYRGFRGDVEEAISQLNAVQLEVAKLRLQQVLAAVNAEQMRRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RN52</accession>
    <name>A0A088RN52_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_191460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698140.1">
        <property type="nucleotide sequence ID" value="XM_010699838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RN52"/>
    <dbReference type="GeneID" id="22574200"/>
    <dbReference type="KEGG" id="lpan:LPMP_191460"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190022200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_191460"/>
    <dbReference type="eggNOG" id="ENOG502SM6K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="257482at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="397" mass="42988" checksum="735B24DBC9EC64E7" modified="2014-11-26" version="1">MVKRTSHIDAQACQTKRRRAHSMPLIGDCMYQLAEELRSCDGVVVIDPQACVALREEAAACTALEALSLLLLDNSSEQRTDGMRAHRLTWWGIGVLRSQQSDVAYNCGEEGVSVLWNVVPLVLTVVPWQVELPLRLRDLVLCQGHFASIGECDYGDSDVGPVPDTFVTREAVALLCGLPRCRIQAISGRFPLFRRVAPSSFSAAPRGVLATDASWSLVSLREVSAAQCAAAAQRHARRLTPFLVGGLSSLMESFASRNDKSAPAECWIAVCYPDGLPRAEAARDEADSVCCNTTNTSGAVPMHVASVHQSDDFCEAAPFSLLPSHLLCQSLHVAVGWQKISPSSRPLAAEALQRLCSLVDRVALRTDQGVPLTSRTTRCAAQETRTVTMTIQKASSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNR6</accession>
    <name>A0A088RNR6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Guanine-nucleotide exchange factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_202130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698414.1">
        <property type="nucleotide sequence ID" value="XM_010700112.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22574422"/>
    <dbReference type="KEGG" id="lpan:LPMP_202130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200026800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_202130"/>
    <dbReference type="eggNOG" id="KOG0929">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="430364at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF388">
        <property type="entry name" value="GOLGI-SPECIFIC BREFELDIN A-RESISTANCE GUANINE NUCLEOTIDE EXCHANGE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="2">
        <location>
            <begin position="663"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1267"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1509"/>
            <end position="1529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1517"/>
            <end position="1529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1872" mass="200194" checksum="E9CA755D8E0DC86C" modified="2014-11-26" version="1">MMSSSLLAQDLHAALPDGGETERQIVLIHVDNTLLAMRTKNRINYHSGAVNGRDASESATTQRLFDLQRRLFAGAVPVSGRISSSSPVHPAPPSKKFPACAFSAEALPDPMTFDLQDNYATYCEVSEWTILSTFAAVCRSPSTSAVVTGVALTALIDILEFPCAFVSIDGVYAAIEAASETRAEVHDNASHEMLLSRIFNVYAAALNHPAAVMADGDVHVRALGRMIMLATDPEASQLLKRTVEKCMQLIVMTLFRRLLYLPADEAAHGALVAAGVKVLGFISRLISGDIACFDSDGCEVASTVAFGSSEGSAGASASGGNSADKASPVENTIALIQLEGLALVQDCLLLLQHFLSKPLCAPLLDTVQNQLCRALLIAGVGTKRTIVLAQTLRAIHLVIQGSSKHLIPQIYNFIRVLHLIPLEALTKELADAGASQQGSPADPSGSPNTGRGSRSPVSSASSGLGNSGRLSVPQLQRMQERRDILLGSLAEFCSDPHFGRFCFIHYDLSWRYASLLPQLSQVLADHAYPLFHGDPEEAATATWMQRRGGMAKDRKAAVQRRQQATVAADYRRDRRQLSMAARRLSRSTQQTALDGMMNMMFGITLRVIAAGASSSRLSEPDVTMSAGTASLSSAEVSHLLQHAQKMKDVLNQFAALFEESPIKKGIPFLLEHAIRVPAGAEEEGSLKHCTKLVLAEPAGGRELGEALYRLSIVLNKRVLGDYIGEQGRNNPEDAGAAEDATKPPALFSVRFFERQLDGFIHQFVFHNKRLLEAIREMVYLLCLPGESQKIDRVMESFARHWYQQNVTYREDGTVVKDETINPFHSESGAFVLSFAIIMLNTDQHSGKVAHQMTKEDFARMNRGIDDGKDIPAAYLGSVYDDVRQHEVVMADMMDRGFANNTTWRLEMQPCVSFVHHVLSAKAVLKEAEALSSISSHEPSTTAAAAATVSSTDAAARACDTKSVVLQTFDLFLFQSLWKRSLLAFDGMLELAVDEVSRSIVATGATVARAVEAAQQQLPAEMATLQSSLRGVCVLARAAHALGLPVVADQCFIGLLKYVVLDDLTNAEEEVRTLYHSVPKLLCMREIFALFVDLYSSLGDSWLPLSRLILDMRLIGLFVEPAQEVGRRGKAKLCGTGRGYSEAVEDSAAGGSLSAPAEPPHALLENTGICADVFAPLIAASATESADAERKAPSERSWFSSLFRGSGVPQVSAVQLSELRDAQGRIGSCIPNMREMLAILQRVVADSHAGHQLVYSLSAVSSIEEDAAGGGISGGSPAPAEEEGKRGNGHTSGLDEASAYAASYELAFICAVVGGASTPTVLQPEHFAPLTTRINGLLREVDLHLHDSRASDGVRAYWCTLGNRVVCASLQLMAVHWRGQHGAVATEQLWACWMRATPSIFALVVAQPVAAFLYDQVVGVGDTENSAGTGEGERDAMQPWACGSEVLVLLAPFAVHATAVSDVAVQRQIGSLLLHVVQQRLYSVANDTESIVSLCLSFSVWVRHSRAAGSNAAAGDTPENSATPNTTSKCGSAAATTLPSGASVLEVLTLCGRNVLLDNTDAAAAGAGGQRGEWCNLWVLVLRSLGALVLCSPDARDSSEAIFCLQRALLDSEAHSLPFSAVVAVYEDILIPLTERLCVPNARVQTGLRWAGGNKVALDEKSGAASSFSRGVLGGFFRSLLSPASPECGEHGAPTTSVAGTSATSRQSTLSTLVFTEVKCRLLSLVPKVLLRYTAALTTQADLLVSLWRQVLGTLYAVYSAYLVIEDATRDDMGGSIPSHDDAVLVQEAVEETVKNMIYVVVSTWNGSSSSIVSGAAGTEQRHAEAFWVAIVQLLQPFAFSAPLIDFMVQAGLARIEAAADAATALGTVASAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPI9</accession>
    <name>A0A088RPI9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_205250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
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                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
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<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPJ3</accession>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
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        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
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                <person name="Restrepo C.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="5753"/>
            <end position="5762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="6125"/>
            <end position="6135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="6353" mass="668040" checksum="1BA239FE4B985A6F" modified="2014-11-26" version="1">[encoded data, 6353 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPM5</accession>
    <name>A0A088RPM5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Histone-lysine N-methyltransferase, H3 lysine-79 specific</fullName>
            <ecNumber evidence="1 6">2.1.1.360</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 6">Histone H3-K79 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">DOT1</name>
        <name evidence="8" type="ORF">LPMP_204240</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60328"/>
            <dbReference type="Rhea" id="RHEA-COMP:15549"/>
            <dbReference type="Rhea" id="RHEA-COMP:15552"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.360"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.360" evidence="1 6"/>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698625.1">
        <property type="nucleotide sequence ID" value="XM_010700323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPM5"/>
    <dbReference type="GeneID" id="22574635"/>
    <dbReference type="KEGG" id="lpan:LPMP_204240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200048500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_204240"/>
    <dbReference type="eggNOG" id="ENOG502RRWZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140956">
        <property type="term" value="F:histone H3K79 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000333">
        <property type="entry name" value="Histone-lysine N-methyltransferase, H3 lysine-79 specific"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025789">
        <property type="entry name" value="DOT1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030445">
        <property type="entry name" value="H3-K79_meTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21451">
        <property type="entry name" value="HISTONE H3 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21451:SF23">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08123">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51569">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DOT1" evidence="7">
        <location>
            <begin position="1"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU271113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN97918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="279" mass="31893" checksum="F1573B4BEB4F1951" modified="2014-11-26" version="1">MHKRLRRVDDAVSQPVKAAKLGSGQELLSFTVEVGDGTPRSPYRLPLRTKPNASRCLHCPTRTCYCVWFGEQLEHCYASLALKRETERIKKRELCAKSILPPFVTRLIRIANVATAETFYDLGCGNGSVLFQVAALTGARCVGVEINPHNAQLAKDAWAFLRPIFEARFKRQLTVEIVCADFCTLLCDAAYFPTPCVIWAANLLLPKSVNHYLSERLRSVPRGTRIMCFEDMYPHSRSLSRLRDPDAFEKFDMLDYEWQPDSVEWCSQTGRFFLYLKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPV5</accession>
    <name>A0A088RPV5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Periodic tryptophan protein 2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_180830</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat PWP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697917.1">
        <property type="nucleotide sequence ID" value="XM_010699615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPV5"/>
    <dbReference type="GeneID" id="22573973"/>
    <dbReference type="KEGG" id="lpan:LPMP_180830"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180011200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_180830"/>
    <dbReference type="eggNOG" id="KOG0291">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3142434at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001291">
        <property type="entry name" value="Periodic tryptophan protein 2-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:003166">
        <property type="entry name" value="Periodic tryptophan protein 2-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027145">
        <property type="entry name" value="PWP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="401"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="529"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="7">
        <location>
            <begin position="822"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="250"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN97264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="942" mass="103288" checksum="DF472BE60A3FB2C7" modified="2014-11-26" version="1">MQTVFQLAAVHGMLYTGGNVVFSPDGTQLYSPVNNYLSSIQLQQAGHLSLTCSNSSISCFDLSPDGDLVIAVGQRGLGFFYSVSARVVLDTLSFPPNCTISCVKFSPCGKYVSVALESTLQVYTAPAKRVVSFHGCHRIEQLHAILTRPITNLDWTADSEHILVCGQDARMKIVPRQGKLHRKGMALQQNSLIGHRSAVLGAWFTREDNSEVVSVAADNVVVTWHRTAITRREILQAIATAQLQARLGEQEESGDAEGGDVEEKDSPSPKSFLERKRLEQLRLDGVRVSAADDTFLPPILRHAFEIRDKFMLSHKGSVSVTAFHKPRGLLAIGYSSGIFAIHTLPETKGGGLTPVHLLSISAQSLTAAAFAPSGDWVAFGSAHLKQLLVWDWKAEAYVLKEQAHYYDIACAAITADSTNIISGGEEGKVKVWKVASGQCFATFTEHTGPITGISTSASTNAFFTSSLDGTARGYDLMRYRQFRVFSPPEQTQLSCIAVDPSGEVLAVGSSRANKIFLFAVQTGRVIDVLQGHEAPIACLAFHPSGVTLTSGSMDHNLILWDLFNQNDSGERLKGDGEVLDIGTEVLCVTYSSSGRRMAVLTAKQEISVYEATVPNDPQLIKTFLTAFDAAGGWRKEVGPNSANYNTHFTRISFSPEGEKLIAGGDSKWLVLYHATQGYVLKKWPITHNLDMQGAEEQYQWRSVSEAGFLGDIDVDEDDMHLSRRKLLEMPGSRHRHFATGKRKTERTARAMDVSFAATGSEFIAATTDGLLLFSTRVARPRFQPLQLQLHVTTEEVRKQLENGQPVLALIGALNLGDVTLGAECLRRMPRDSIPVAVTAIPSSLFPQLMQWVSEEVEHCRGLEHALLWAQSLLLHSNEAFGGVAAQQDVRVLPALKTLQRSLFQHRLLTELSRENYFSVKYLADAARMNSSKLEPIAEDTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPY5</accession>
    <name>A0A088RPY5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_181230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697957.1">
        <property type="nucleotide sequence ID" value="XM_010699655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPY5"/>
    <dbReference type="GeneID" id="22574013"/>
    <dbReference type="KEGG" id="lpan:LPMP_181230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180015600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_181230"/>
    <dbReference type="eggNOG" id="ENOG502RDGJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277284at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="CDD" id="cd10527">
        <property type="entry name" value="SET_LSMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1410.10:FF:000021">
        <property type="entry name" value="SET_domain_containing_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="371"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="628" mass="68060" checksum="F8BFB1A15C6DFF7B" modified="2014-11-26" version="1">MKCGMRLQASVLLLHIHRSLQSLQRLYTCVTLPELQEERQLVGRTATAELPHRADAHRVRAALPTSFPPDPHTAEEGDRVLRFFCQELGMGEAPLRQWRHKLQQKSAQRWGVPKTPSSLLFPPMSSLSSSHNTPGLHPTAVGGGTTVPCWTRVRDAQAATTSAPSASAAPSSAAYASESVSSSSFLWLRPRLQDIAVVQSAMRSLQFMVSPFLLLSPPPLVAASPPCSGSTDPSAAVPHDAARPASYEECSRWYATRPIPAGMFLMSLPTEAVLFANPPPATDPLITYYMQVEELVGQLVSAVADVTSPHHGYTSYLCDSVVPSRNLPFLTTADVQQLFRATTDGSTTQPPQVPAHSADAGDDASEAVDSPALSLMSFFHEDMAGEPLSDYLRTRLSRPEYAWWVSLVLSHRTGTTSLLPMIDKLNHSPFPNCYYTMATEDTMCGIDVLDNLLAGVPGELLYQPYVHVFALRDIPAGAELTLCYASASDGAYKPAGRHLFAQPPSLLAEERSDARRHGSAAIADAGDIEEVMRTLFPHSDVVALAESVGGISGGGANVDSAFASQLRRLQHPGRQEVDTPEGKASWLLQWGFVPPCDALYSAQDLREMATLIVERRVGMRSSLFPRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQF2</accession>
    <name>A0A088RQF2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="8">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MPK4</name>
        <name evidence="10" type="ORF">LPMP_191330</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="8">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="8"/>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698127.1">
        <property type="nucleotide sequence ID" value="XM_010699825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQF2"/>
    <dbReference type="GeneID" id="22574187"/>
    <dbReference type="KEGG" id="lpan:LPMP_191330"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190020300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_191330"/>
    <dbReference type="eggNOG" id="KOG0660">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07834">
        <property type="entry name" value="STKc_MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000040">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000046">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="30"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN97474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="363" mass="41784" checksum="0AC32D41E563E6C3" modified="2014-11-26" version="1">MTQLVPLAELPSGKKIYSVRGQGFEVDREYDLVKIIGFGAYGTVCSAVANRSGERVAIKRLSRVFGDLREGKRILREMEIMTSLKHSNLIRLHHFLRPHSKETFEDIYFVMDLYDTDLNRIIRSRQKLTDEHLQYFMIQAFRGLHYLHSAKVMHRDLKPSNLLVNADCALAICDFGLARDDQVMSSSDLTQYVVTRWYRPPEVLGMGFNQYTSAVDVWSLGLIFAELMVGRTLLPGTDYIEQLVMIVNLLGSPSIDDMEFLSSEARAFILSQPHRPALPFRDLFPMATEEATDLLSKLLVFHPARRLTAKEVMEHPYFSKYRDPAEEADAPNPFVWNHSHIETKAQLREDLWRVVEAYSHSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQZ0</accession>
    <name>A0A088RQZ0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-dependent RNA helicase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_201250</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698326.1">
        <property type="nucleotide sequence ID" value="XM_010700024.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22574334"/>
    <dbReference type="KEGG" id="lpan:LPMP_201250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200017900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201250"/>
    <dbReference type="eggNOG" id="KOG0920">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5600252at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00048">
        <property type="entry name" value="DSRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058737">
        <property type="entry name" value="DSRM_REH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF235">
        <property type="entry name" value="DEAH-BOX RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26536">
        <property type="entry name" value="DSRM_REH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="802"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="1043"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="145"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="252"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="543"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="710"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1002"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1162"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1782"/>
            <end position="1821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="189"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="558"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1004"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1167"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1800"/>
            <end position="1813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN97619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1821" mass="198645" checksum="3788FC759A1F413B" modified="2014-11-26" version="1">MGTFSHFFIRGSGLCVIAAVPGMCSSMSCLCWRPWRMQTRQWEGRSCVLLTVATAACHLSNGRAGTAHVPGNSGAFSHTSSSAPRYRSQECGAIDSRTSPQPHRVVRCCLKRTTPSPAKEAVSPAVKSSSRDESSLAALLLSLETVGPSNTQRQQSALPTSSRQRTQRLTPTLFSPAKSQARAEPKTTPVLSPSSSCFPNNSTAASELKRTGNPTQRPPHKCAEMNRYSDQPLQQGTFSSMGEQREQRVQLRRARRRMSRTPQASRIRSLPGGKLEDATGVSPLAVDRGAEERVVEMLRRSQQQTSPDAEFAMREPTVHHIPHSKLMRCVLELPLSSRCDGDCAEQKEVFAIGQSRKAKIARALCFMHAEQLLDHYMSSRGRPSSPTTGASAVPPPLEEAVLPPLPKTPQPHEYCSWDEYVDASAAYVQAVAAHVKQEGYMREEVLQSGHPVVDRATELLRRYPKRYCRPTALQDLNESLRDASSLMTTAHLAGAVFVATLVLDPRTGLTATGVAKNMKTAKRQCAAHALCILQLLKEDVERQQEADGTGHSRRRSALKGSSSGSSTKKGLSHQPSAPLESILRQLQPAYRRIVQYHHLLFGKASLTPQTNFTKESNTTSGSNSTITYRCHLTLNGLCCDATGINRFEAERAAMEAAMTNLMLYDERLQAVQAFVNAHLSISPESIPSAALPAELVFQLQAQLRQVTQQPEDVAADAATDVATGKTGSDDGADIADDRSDRARGMSERALLDLTQRSFARDPSYAAQMLQSMLALRRNPVYLTQFHPCRSTLAMATVKAQLLDAVQRHRVTVVCGTTGCGKTTQVPQYILDYEIEHGRGGLCNILVTQPRRLSSFSIAERIAQERLGTVGEDVGYAVRLDARPGRHITICTTGVLLQIFSTHPELEHISHLIIDEVHERDINCDVVLALVKQLLARNLRLRVVLMSATMQADVFARYFGTDTPVVQVEGAVYPVTIRYLEDIAAEAATAQFCSPSLDAVSSADSEQHDEGKKREHTTPTPLVKSPTTASRRVNARKYLKIDYNLIAYLVHRSVQVDLQNNTDGKSILVFLPGWKELTSAMAAIMEYSGPYALPDAKGRFYIILLHSTVDNAKQRECFMPAPPGTVKVVLATNIAESGITIDDAAVVIDTGLIKTTSWESRPTLPCHQGTTDTIGSSSSRRPTVAHVPLEKVPEDGRAGGGRGSGDTAASTPFFSTQLTLGYASQANCTQRKGRAGRTQGGVCYRLFTKELWNSLPAFPEADIHRVPLMQVLLKLLSLGHTNPKATLQTFLEPPSSTNVDASMEVLRGISAVGKTDTLTPLGEYLALLPCDPRIGKMIIVGAVLRCLDSVLTVAACTDVCPYVTSRDVAAEARKRRYLLSRSSQSDHISFLNAYNAFCANGEKEDFARLNLLHLGNLRVISKYKAQYRDILRHAGLISAQDELEEDGERVDSIDAAGDPVHGHLGSDGGTIKETAVHSEGGKLNLSSGDSRTQDVRVPGWVPLSYSGTLCVDTSALSRHSFDVALVKACVCAALFPNVAVLRPPANTLSSMRRLHAARKVELRTKHFFSIKPTKDSVCRRVDGPRGGDAPGRDELLRELWRDSQAVTTDSTTSSTSPVQPVPALFYVFQDVFGVRDPRRDFLTSLSAVSLWALLLFGASESTTEYNAELSICVVDGWIAVHIDRATYALVTQLRQSLFQCLRRKYHNPQDPQNNSALRTVTEVCRRLLKAPVLEMPAAKSLDTAGSTTCKAAAGRQQSPWQLVDMGTIIDPLVHLRHRDSADGSATAVTGENALLNLDGGGDGDEDDDDNDENATADGDQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RR47</accession>
    <name>A0A088RR47_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_201500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698351.1">
        <property type="nucleotide sequence ID" value="XM_010700049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RR47"/>
    <dbReference type="GeneID" id="22574359"/>
    <dbReference type="KEGG" id="lpan:LPMP_201500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200020200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201500"/>
    <dbReference type="eggNOG" id="ENOG502S4D1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271562at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="278" mass="30356" checksum="7844334542181C54" modified="2014-11-26" version="1">MSLFARSEQSVKSAYHCVTLLDNWDEDRRQFGQPVPTTSGTGDFDPNTTYNTSYKALTAAQTAEAKPPGCFAAEAPRILLFHHGDIGNIQTYCHATSELALTDRNERVYTNDEVLDMPGVSSRRKKTAALQKSMNGFSASRSDHSGALTGGLDVDEVSAAVQREALYLQSMAKTVCSTPYLASQMQTSASYSGGEKAATTESESGYAPPRLLPVGRVAERERLLTTKNVSIDATGMYVCDNLDAYPLTSSQCVGKMTKSCDNPMHKTNLRVHYMEDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRJ8</accession>
    <name>A0A088RRJ8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_203540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698556.1">
        <property type="nucleotide sequence ID" value="XM_010700254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRJ8"/>
    <dbReference type="GeneID" id="22574565"/>
    <dbReference type="KEGG" id="lpan:LPMP_203540"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200041700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_203540"/>
    <dbReference type="eggNOG" id="ENOG502RZU7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276855at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="197" mass="22857" checksum="F34E9A1066CFD98E" modified="2014-11-26" version="1">MSFTYQRMKMRATTIAVDHMRSLCDGCNLVLGAVTHPFKRLIGRVKAEAPWVNTAVACTFITILPLIFYPYIKKYVFNDERAAAEAERVRLCLQKGIDPYPYMRHKDFVYGNSAPVLANEEQIPKRIGWEFNALENYYKRKEELRQEVGGNIDDTVKKLMELKREHRGMYDRMRGKPGTEPRDLIFRGSSEGDKLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRK2</accession>
    <name>A0A088RRK2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM5</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LPMP_240890</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699429.1">
        <property type="nucleotide sequence ID" value="XM_010701127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRK2"/>
    <dbReference type="GeneID" id="22575498"/>
    <dbReference type="KEGG" id="lpan:LPMP_240890"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240014900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_240890"/>
    <dbReference type="eggNOG" id="KOG0481">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10036721at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000025">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001327">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008048">
        <property type="entry name" value="MCM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054125">
        <property type="entry name" value="MCM5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF42">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21933">
        <property type="entry name" value="MCM5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01661">
        <property type="entry name" value="MCMPROTEIN5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="14">
        <location>
            <begin position="364"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="575"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="588"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AIN98722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="802" mass="87137" checksum="3543BD4ACFA7B8B5" modified="2014-11-26" version="1">MQSDLGTVHVTNFHGSDALPGDGYNGRGSVDGNSEVGADIRLLTKEFVTRFRLHHEFLYMDMLRSNLSAGLHYVELQMSHLQQFSGVLFGAVQHNPTRALPLMEHAMWELAQERKLFPAYSRETTIQVQLFWGVPPMSLRNLAQAAVAQLVCVSGIVVKSSSTHARCVRAAIQCTSCRSKAYINGGRSIDLPPQCMENSGRGGAGGGGLGSGGGTSSAKCRPNPYVLLPMESEYEDQQIIKLQELHEDVPTGELPRHLTVVVDRYLVDRISPGSRVQIVGVVSVQEKRGGFDNARGGGRGRTAVGLRAQYLRCVGLMFRTTQDVCCAVVSVNQNFSSRVRSRTTMTWQPEEEASFKAFAKQGGVFQRLSASIDPAIFGLEDQKKAIVCLLFGGTRKRSGSNFLRGDMNVLFIGDPSTAKSQLLKFVEKVAPIGIYTSGKGSSAAGLTASVISNGNGDFVLEAGSMVLADGGVVCIDEFDKMREQDQVAIHEAMEQQTISIAKANLTTMLNSRTSVLAAANPTLGSYDPLRSNEDQMDFQSSILSRFDLIFKVIDPRNPETDQRLAHHVIGLHKSASGNGRRCGGGRPGASASAGSGASASAAQSSHGEVVDRGFFTKYISYARSTCRPVISEEAMKVLLDFYVQVRRDAHQQTLQAISGNGSAAGGGGASSSKTPIIQITARQLESLVRITESLARMRLDVLASRSDAEEAIKLFKIATVDAIKSGVADQTLTEAQSELVLRVEEAVRRRVTLGATVEHHRLLSELARMGFDAKLVERALYAMVKREELEWRKQRTLLHRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RS25</accession>
    <name>A0A088RS25_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">Coatomer subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Beta-coat protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LPMP_205530</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 14">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 14">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 14">Golgi apparatus membrane</location>
            <topology evidence="1 14">Peripheral membrane protein</topology>
            <orientation evidence="1 14">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Cytoplasmic vesicle</location>
            <location evidence="14">COPI-coated vesicle membrane</location>
            <topology evidence="14">Peripheral membrane protein</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN98044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698751.1">
        <property type="nucleotide sequence ID" value="XM_010700449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RS25"/>
    <dbReference type="GeneID" id="22574765"/>
    <dbReference type="KEGG" id="lpan:LPMP_205530"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200062300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_205530"/>
    <dbReference type="eggNOG" id="KOG1058">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261439at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000444">
        <property type="entry name" value="Coatomer subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011710">
        <property type="entry name" value="Coatomer_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016460">
        <property type="entry name" value="COPB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029446">
        <property type="entry name" value="COPB1_appendage_platform_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635:SF0">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07718">
        <property type="entry name" value="Coatamer_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14806">
        <property type="entry name" value="Coatomer_b_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005727">
        <property type="entry name" value="Coatomer_beta_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 14" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 14" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="15">
        <location>
            <begin position="26"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit C-terminal" evidence="16">
        <location>
            <begin position="702"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit appendage platform" evidence="17">
        <location>
            <begin position="849"/>
            <end position="990"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR005727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF14806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AIN98044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="999" mass="110136" checksum="BB0DA6B8347769BB" modified="2014-11-26" version="1">MAETTVSSQEESSTLLVSVGKTVSAMSSKEIKIALEKGDNTARANALMAIICLHVNGEPQNYLIMSVIRYITPIDDHFIKKLVLYFWEVIDKRDANGNLLSVIILICSFLRNDLLHPNEYVRGLTLRFLCKVNEVELIEPLVSAVVQNLSHKVAYVRRNAVLTVHYIFKKFPQLLPDAPELVESALRTETDVSTCRNGLDFLAAFAPERAASYLNDFRDSHTLSAVDGPFLMSVVEFCRQMIRANPYEKARYVPVLFSVLQSKSAAVRYQCATTLLSFSSSPTAIRQATLTYVDIIKVHSDNSVRLIAVEQLNQMRRSYLYVLQDSLLDILSVLQDGTMTIRERVIELAVELVTRRNAETFMQAMKKELLRANRTDFEVEDANGAMSYRLLIIKAINTALLRHPPSAPSMLPVLLDYLCDTTSTSKEVITLIKEVLLSQPELRRDTMKKLSDIFPMMTSVPVMRTALWMFGAYASSADEVLQALSMLKNVVAPLPLETPKPAALDAATLTAANNNTSPQPNMRAVTKVLEDGTYVTTYTTATPTPAATAANGHGEDGSLDVSSSGLRMALLRGEYFLASAFASTLTKLVVQLFTEEAKGAVDEATRNAAQSDALAILREILRYGAEADSPNPINADTNEHLRLNIELLSNPQAPFMLDVLHASLEALGRAERRSTREVGKADGGVAATAAAAAAAAVQLNAIDAPVMFSQLSEDKDAIFELDAAADGLDAGAKDESSEHKAQVFLKKLEDTMPLSGFNDPVYCEASITVHQFDVSVDWLLVNCTSKQLTNLTIELVSLGGMKLCERPQTYILNPHETIAVRTSLKVSATESGVIYGTVLYDAPNNQRCSFILNDIHVDIMNYIHPSSCCSAEFREKWGIFDWENKIAVSTMRRDLPSLVRFIVQELNMQLLEPYEVEQQEEQDPELDLLPTSEESEGCAYVSCNLYAQTAFGEDALANVSVESDGKGLVRGVIRIRSNTQSIAYGIGEKLNMLQKSGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RS46</accession>
    <name>A0A088RS46_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_240550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699397.1">
        <property type="nucleotide sequence ID" value="XM_010701095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RS46"/>
    <dbReference type="GeneID" id="22575464"/>
    <dbReference type="KEGG" id="lpan:LPMP_240550"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240011400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_240550"/>
    <dbReference type="eggNOG" id="ENOG502QR4V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="262173at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33604">
        <property type="entry name" value="OSJNBA0004B13.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33604:SF3">
        <property type="entry name" value="OSJNBA0004B13.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="359" mass="39428" checksum="B20599B3A525A8B2" modified="2014-11-26" version="1">MFSIASHPAYGRAHGKRRRSVFLLGIALTTIVLVVIGSMFINSPIISEDTAMINNAYVRAHLSIRGEWVDADTRFAESADSVVVNTNQLLQLYRLRVFVVATEQEVRDLTRLLNALSNSNYSTRMFPIDIAVHVLGNASAVPFVPWSHGRLDVYTHRLHSNASASAPLWMADLWQPQSDFELGMLLTASARVSPHWFQWVISALQQYGSVSAKTVVKLDPDKYSPTERRRLLSPLSKRLSGLALGMPVAGAAAKAVVTVVSAYPSATSIFTASYWKSVMARAGPGTNIDDTPASWPAFLRTATTVLGHSKHRFLYPPLGKYGPLVCENTNCAIHLLSEAQLAELVKLPMSEDQVPLSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSE3</accession>
    <name>A0A088RSE3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_250280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699600.1">
        <property type="nucleotide sequence ID" value="XM_010701298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSE3"/>
    <dbReference type="GeneID" id="22575676"/>
    <dbReference type="KEGG" id="lpan:LPMP_250280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250007900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_250280"/>
    <dbReference type="eggNOG" id="ENOG502QWS2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="247306at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="584"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="859"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="406"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="722"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1009"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="859"/>
            <end position="868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1184" mass="129723" checksum="E93B4DA8CB8D2460" modified="2014-11-26" version="1">MVLSQRGLPVSSDSAGAAGRFKRQRVREAEARRQEQRVEDVLTHTTHIVDAIATINGKYVLTLNDERARLVHQVTELQTQLTKHQRQHAEDTTHLVLSEFARLRGVVSSGVKDRLLQSLREEANKGHADVFDAISAHVDDALQGSLAVADTELSAERQLNHTLVQQLQNYTQTLLREVKGATSRAFQAEVEVMQRDVLVAKLQAACVFAQNRQVRHEQEVDALMRVVAQLAEKSRYAESARADVRRAKHHVRLLEQHLGLNEIVAAVQAEMARAPSDASAEVRQSIGPPLAPDPSLRSSAPHYFAMKMLEHKEVTLTELVDSWQQQESRIMEAEQRYARLEGVVSRVQHDALVVHQRYLEEKQRREIADRRITDMVRERLHPQKDLAISQEVQRLRWAYTEVVDDAAQLAVNLKVCRDELQRSQEDAARLSAQVRQLQRDAETDQVALTIRELRNEYAARVRDLEEESTRAEMQLSLAQRVSKQYGAAATEATAALQRAAQANRELSSAALLVISGDRSTLATSSSAWREEVELVEAQAERLLSATAAAKEFAAAHGELYDTQMEALMRQWTLVREAEMQVRVPSTADSQLGEGRLPTVGHNSTDDYTESRTLVSSSIAAEESMDKANAVLSASQFALREALMLLNASLQSTDVERSHLVDASLSDAQYVTELIAEVRRVTAERDRLRAQVNVCQELLEKNHVTVVERALMHDVPVEDSLNVAEATERIEVLKNQLAAAKQVCERALNEVKQVTAEKGDVELRLTELAREHEVLQRHTSRLTDRLHGSLARESELREKNMALQTQLTDLVQLPGVTTVEAEASSIAPHTTSARLTDLFSSLQESLGSLSVEVGALRRERADGASRETDVGSGDNNGPDADGVEDALLVDSLSRSGMMSIVRVLKETLHKVGLLKVSLRSVAGAQAAGLCAAAKECGNADGGSGAALTANVVPPPSPETQQRALEYRYSLLEAKLMSMVAERLEMQGRLQKAEKTTADMEAANQRLLTISKSVIEKQNTLKTENEQLQAQLRQLTTAANAASTPLPELLAAPGLTTAPVSAQMPTPHEGAVTPIPYAHAVGISVPSEHVEWSATVAPAYSTSATQPRAPTRIDDPPVANASLPHSGVPVPQEQIEEGTGRAPEGVAANVAVTSSSEPINENVVPQTEASLMAVEDLAEAVSGPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RT01</accession>
    <name>A0A088RT01_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallopeptidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_251670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699737.1">
        <property type="nucleotide sequence ID" value="XM_010701435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RT01"/>
    <dbReference type="GeneID" id="22575815"/>
    <dbReference type="KEGG" id="lpan:LPMP_251670"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000048000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_251670"/>
    <dbReference type="eggNOG" id="ENOG502S4HP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269301at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JAB1/MPN/MOV34 metalloenzyme" evidence="1">
        <location>
            <begin position="10"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="319" mass="35724" checksum="317EDF22422E97D2" modified="2014-11-26" version="1">MSSEVSIQLTPYPAAFIIEHAKRKKYAAGYILGTVRAEEIVITDFIPHTHKDTEVPNTKTHRAELTRRRAAKRRHTTQDLIGWYSAGQPGADLTEEDYQLWCNSPSVIFQGRHCLHLHCEMPHEDAATPKVTWTASVVFEDPADRTLKHINHKVTLAPMNNLASDVMLSHITSLSLYNGGHPFARSKLQNLDEVAYVASIDHKSSTDAVDEVQRRLVRAVEAAQEVVTGGSGGGKEAHEMMTAVENFRAIRDEALKRQRDQTGRMDFNSQQFKDALMIKCAATILRREIDQIEHLATVYGDDAARRNNATGGENSEKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTK7</accession>
    <name>A0A088RTK7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_261170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699937.1">
        <property type="nucleotide sequence ID" value="XM_010701635.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22576020"/>
    <dbReference type="KEGG" id="lpan:LPMP_261170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260016600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_261170"/>
    <dbReference type="eggNOG" id="ENOG502S9P4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267507at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="617"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="863"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1068"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1246"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1601"/>
            <end position="1631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="873"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="923"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1099"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1161"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1259"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1614"/>
            <end position="1631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1695" mass="178086" checksum="FC2FDAA38216BEB7" modified="2014-11-26" version="1">MGTLYINDVRAHIASILESSAATTALNPSGSPSAEGVGATRRYQTRQQEGSHNHPLNLPSQHGGGGSGLFESTTPLSGAALYPVSTSCGKPLVTPRRGSSPNRSGEGAKSARRSTEAALLALQEPNVPTATSPSPAVPLLGESAVGVTLTSLKQRHRLLSPTMTTPRRRSPNGDGAQGAGKPSAGRTNSTFSTAVGGSYAIHVCRHPLYSGRGAPQRRRTSPPLAADKATGVQGGLSISVEANTVRRLQRSVRGKPTASVAVTKAAPAKAVTASDVCAMVRTGQTRLPGRRGSVIEQLAAATQLKISDDPTVGQAAYHLHANTAGGRDSKHLGPLQLHDVMCMRLQEPPSNVSARRTNEVDRRLPNDTLVLAAPERMQNGEESPTYTHLKAFQMPHKCTAAPVAGISTSEVSPLPSGADTLYPATLAGATAAGAAPPPPPPAVPAVAGADDIPAASAAETRMNVSTAATIFGAPFSAQPLSARGLRKEEVAAAGDMRLLGDLIAASHHDHQSARATMAADGGESSTALLPASRSHMSLFDSATTSTGPTTAADFTAAMAIGLQLQRVRGDSPPVGWWRPPANVLLPDPTQSVPTWTVHKSASAQEAQQAAAMAASARPTGGAGVNHSASPANDLTAAAPDTVDGAAGGDGMPRMSDCIDYHAPFQCVLCPEYAENDLVPAALNAGAAVDTGVDDLMTPRHTHYATTGIAAGATVEQRDGVNMDALATGAAVNSGTTLKPLAAQAVILRDPLSLLACEHLAEDTVDVTARRRAYLSAMNAMHGITRGSALFTARPGALTSMLQEASPPSVVFCKLSYPAKILLSAILYMRALGALPSLLRVGPLTEYSPIVDKENCIELVFHNPSGEEGDEQATQEQQLMPSQYRSAREGTAGSTVAHREAPAARTSLIEAVTPTYARERARSQPLTARHPSSNPGTLLRNRSRSQSGNTAHDFTGGTFAKEGATQASRAHNYTDASPTQPQQRLSVIEARLMKTLSATSVRRASSLTSQSFNTAPSTAHTVSPHRLFSRASFTSLAGPPLHSAELSVVVDGTPDEVLCLPGTGGGKMWRSENGARLPRNASRNRSVPHGFARRIGGQGTNADENLSGNDNVLRVYADPTSGRQRRQRPSKSPPKPPRHGSERASAAIRHVPRVCTTPPLGTPTSSASGEVSSTAATTATVTPGLRRSSFIVALEDLQQATQEGGVSAVARGVNTPLPPPHSPSGCTESLLSALQPTKVMPPSPTHFRANGSTATRGRGAEAAPASGAKPASAYGPGATRFLKGEQELCVVLRAVVAQKSHVYSFGKAETVHVLPPLPRRSADRDNSKALLRKQTMQKMEELERIAAGPSNPLFKLLCGSTKLCGGVKIEADQWKAALLDRARRAAAAMRQHRPVMVNEHNMPVVDDYGDLVVAFLLSGNASELSGSVPDMMELEALRYRIFSLRGYSVNDPAGMQAVREAAAVGGASTADRARLQQDSASFTAFQTSVSPHPPAGETSFGATCASPRGSIMGVQRRPSFFEAALRPSDPLADLANGDGGRGRYLTEFDIQQLQKKQQQQQVQPQDMQALIQRRYPIYRASSVAESTLQDFFAEAKATVAAAHQRGRRRGGAKPSNGHRSTSGGRSSSPSSLLDHLARHTHADAAATALQDVERDLLRFRPMNLNSFHRELTDAVQCALDLQIWQGKENVLQAFHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTQ6</accession>
    <name>A0A088RTQ6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="2">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_231760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699331.1">
        <property type="nucleotide sequence ID" value="XM_010701029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTQ6"/>
    <dbReference type="GeneID" id="22575381"/>
    <dbReference type="KEGG" id="lpan:LPMP_231760"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230025700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_231760"/>
    <dbReference type="eggNOG" id="KOG3157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264196at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06822">
        <property type="entry name" value="PLPDE_III_YBL036c_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000007">
        <property type="entry name" value="Pyridoxal phosphate homeostasis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00044">
        <property type="entry name" value="YggS family pyridoxal phosphate-dependent enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PROLINE SYNTHETASE CO-TRANSCRIBED BACTERIAL HOMOLOG PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146:SF14">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE HOMEOSTASIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01211">
        <property type="entry name" value="UPF0001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1 2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine racemase N-terminal" evidence="5">
        <location>
            <begin position="13"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2 3">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN98624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="245" mass="27103" checksum="700B530EC54D3460" modified="2014-11-26" version="1">MSRYDIASEPTAEALARNYKAVCDTVAQESGNRRVTLITVGKTKSPACLLSLYNLGQRVFGENYVQELEEKARELPGDTVWHFIGHLQSNKVRELLEGVPNLHVIQTIDSEKLANKVNEGCKKYRSGRSLEVYIQVNTSGEETKSGTEPGEATVALAKYIVGECPLLQLKGLMTIGMPDYTSRPENFECLTKCREEVAQAVQVAPEDLELSMGMSGDYVNAIRMGSTTVRVGSSIFGQRYYPPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTV4</accession>
    <name>A0A088RTV4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3592 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_240090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699351.1">
        <property type="nucleotide sequence ID" value="XM_010701049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTV4"/>
    <dbReference type="GeneID" id="22575418"/>
    <dbReference type="KEGG" id="lpan:LPMP_240090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240005700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_240090"/>
    <dbReference type="eggNOG" id="ENOG502QVS7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276026at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021994">
        <property type="entry name" value="DUF3592"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12158">
        <property type="entry name" value="DUF3592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3592" evidence="3">
        <location>
            <begin position="73"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN98644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="222" mass="26024" checksum="548DF5536AE63D4F" modified="2014-11-26" version="1">MSSGRIYKFIFRKEQPQWLWDLALEVRLPALFLVGVVYVNTKCYYDALSSYQAGSRWGITQGKLLELRKLNYRHISVPRYAVKYEFEVDGKRYVSTRGTTGSPYRNWMEGWYDDTITEAEYLQAIPVLRVGERCSVFYDKKNPKAHSALAQDANSFEISFLGFLAFFPLLMGHYMKAHFWMLRKAYMPNKKIRVRFPVYDHPKPPPPPPKEPRHISQSPPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTX2</accession>
    <name>A0A088RTX2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">D-alanine--D-alanine ligase, putative</fullName>
            <ecNumber evidence="10">2.1.1.354</ecNumber>
            <ecNumber evidence="10">6.3.2.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_262530</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-alanine--D-alanine ligase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.354" evidence="10"/>
    <dbReference type="EC" id="6.3.2.4" evidence="10"/>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700072.1">
        <property type="nucleotide sequence ID" value="XM_010701770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTX2"/>
    <dbReference type="GeneID" id="22576156"/>
    <dbReference type="KEGG" id="lpan:LPMP_262530"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260030200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_262530"/>
    <dbReference type="eggNOG" id="ENOG502RSJ8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2017037at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23132">
        <property type="entry name" value="D-ALANINE--D-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23132:SF23">
        <property type="entry name" value="D-ALANINE--D-ALANINE LIGASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-grasp" evidence="9">
        <location>
            <begin position="119"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="7">
        <location>
            <begin position="344"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="8">
        <location>
            <begin position="469"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN99365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="516" mass="58660" checksum="1CED25EB3CD94939" modified="2014-11-26" version="1">MTETLAKPIRVCVLASSYEGSDSELKEYEGDLTQTPQNYFCSADANYAFHLELIKKATAYRQIRQLVMSGKFDVFYNQCDGAKDEDRAGVEVVEALAEFKVPHTGAIAKYYEMSKPDMKLVAHYYNIATANYAVLEPGDDIESLCGHLEFPCIIKHISGYSSVGMDKSCKVYNMAQLVDRATRFMAEYQFALVEEFVSGDEATILACNDCTQPEGVRVFPPVQVTFPEGEDFKHFQLKWASYEGMKWKQVPEMDPALQDMISIARSAFKRMMGGIGYGRIDVRIDRQRNNKVVFLEINPNCGIMYPYGQEGSADWILRLNKGFQQRDFAILQIREALARCQRERLLYVRRFDPARGYHLRAAEDISVGTTIFQDECRPVRLCTKPYALEHFPKEDYSDFQQNAWPVGRDGHYYALWDHDPAQWRAFNHSCAPNMSFAPRRSLNVVALRNIPKGEELTMDYRQFMDSTMPGFQCNCGTEKCEGYVSPGSLSDSPTAKIESPPMVAPQHSVAMKLNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RU81</accession>
    <name>A0A088RU81_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_280210</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the histone H2B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700364.1">
        <property type="nucleotide sequence ID" value="XM_010702062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RU81"/>
    <dbReference type="GeneID" id="22576466"/>
    <dbReference type="KEGG" id="lpan:LPMP_280210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280007400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_280210"/>
    <dbReference type="eggNOG" id="KOG1744">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7686794at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000084">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="10">
        <location>
            <begin position="29"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN99657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="142" mass="15825" checksum="B8A74509C459D034" modified="2014-11-26" version="1">MPPTKGGKRPIPLGGKGKGKRSAGKAPKSASDRKRRHNQKRNQHWDLYIHRALRRFFKRGTLSKAAVRVLSSFIEDMFNRIQTEAVFVAKINKVKTLTAREIQTSARLLLPPELAKHAMSEGTKAVAKYNASRGEAYAQGGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUI7</accession>
    <name>A0A088RUI7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">DNA repair protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LPMP_250760</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699646.1">
        <property type="nucleotide sequence ID" value="XM_010701344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUI7"/>
    <dbReference type="GeneID" id="22575724"/>
    <dbReference type="KEGG" id="lpan:LPMP_250760"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250013600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_250760"/>
    <dbReference type="eggNOG" id="KOG1002">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000081">
        <property type="entry name" value="DNA repair protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1740.10:FF:000010">
        <property type="entry name" value="Putative DNA repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000077">
        <property type="entry name" value="Putative DNA repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.10">
        <property type="entry name" value="Zinc finger, PARP-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001510">
        <property type="entry name" value="Znf_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036957">
        <property type="entry name" value="Znf_PARP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00645">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01336">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50064">
        <property type="entry name" value="ZF_PARP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PARP-type" evidence="12">
        <location>
            <begin position="31"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="162"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="791"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="934"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="344"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="452"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="850"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="452"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="468"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="868"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="888"/>
            <end position="897"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AIN98939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1098" mass="123587" checksum="E00FE270462B31C8" modified="2014-11-26" version="1">MMSNFAQHPDLTLNERLVWRPAKGKDQVYNYILQKAPTARARCRKCSQLISKGEMRVGVPIRHNAGDNGWISAWQHLGCTRMEKSESENYESTMHGFTELKPEEQVHVVNEINSMEMPDHLKPLDPNDLMHRGKMEQMSPPSALLRHLLPYQKEGMGWMVRQETESPVKGGILADEMGMGKTIQAIGMMLTHRINGPTLIVCPVSSMLQWEAEIKEHVVPGALSVVIVYRTTKVTKEELENADVVLTTYPMLEQAWRALINEIKVPCPYCELLFIPRQLVVHNKYFCGPRARKTLKQAKREKHTAPAAVSNSRGLQSNETIRKGLRTLHVDLGEEEVAEEEVNAFNATTAQPQRKRCRKDAANGTVDPAGEVNGGSISAAKKEKQEESGSKVVDGCQSSPEKATFKCSIKVEDATDEVTALAKKGTVAQPAAASRGVVGPIGMYQELMREAGRTVRSRWDAARKDGESSEDENMAESSEGNDSDASDLSYDSAAAAAEEAAAEEQASKALEAFRCTACHFQLLRYPFCPKNGQHHVIREDLRDIIEKDTGGDDVDLDASIFHSIKWARIILDEAHRIKGRTTSTARSAFALVAEYRWCLTGTPLQNRVGDLYSLLRFLRMRPYAHYYCEREGCSCASLSHPFSSTSLHQCVFCGHGPLQHHSYFNRYILNPINRYGYIGDGRRGMMMLSNDVFSRAMLRRTKVERAADLQLPSLTVEVLHIQLTREERNFYESLYKKSTAEFDTFVHKGTVLHNYAHIFQLLSRLRQALDNPLLVMHGMNVGTVVNVKGVCGICGDGIEGESALKVHPCRHQFHRLCLGQFLESAPDNEFHCSICFVRINVDLRQLRQDAEEDDDEGIGGFAAALPPELEDEVNTEENDDAEGNEDGSLSQVSQYMQNKGRRRTTHTAPTKKEQRSILTRLDPQKPLHGTKLDAIADYIERVPKDEKVVVFSQFGSMLDLMQYWLQRRFIKAVKLCGSLTLTQRQSVLQAFLHDRSVRVILISLKAGGEGLNLQVANHVVLTDPWWNPAVEMQAVQRAHRIGQTRPVHAVRFVTEHSVEERMVDLQEKKMLVFEGTIDGKLQSLNKLTEEDLQFLFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUL2</accession>
    <name>A0A088RUL2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_280370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700380.1">
        <property type="nucleotide sequence ID" value="XM_010702078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUL2"/>
    <dbReference type="GeneID" id="22576482"/>
    <dbReference type="KEGG" id="lpan:LPMP_280370"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280009100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_280370"/>
    <dbReference type="eggNOG" id="ENOG502SNYX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="257437at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="125" mass="13916" checksum="4F1CCE89B8452436" modified="2014-11-26" version="1">MLAALSRSPVPALIVPHVCRGAHLSLEAVRAFFEHAFCESLPLTHTDLVRSAYSPLMEDAPHDEDTLTSGIEVACRSLQQQWTKHAEEWEELLYGRHDLADAQLGLCPRPCTWVEDMMAGGAYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUM8</accession>
    <name>A0A088RUM8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_282290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700569.1">
        <property type="nucleotide sequence ID" value="XM_010702267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUM8"/>
    <dbReference type="GeneID" id="22576674"/>
    <dbReference type="KEGG" id="lpan:LPMP_282290"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280029200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_282290"/>
    <dbReference type="eggNOG" id="ENOG502RYDU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="55"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="241" mass="27291" checksum="39CB568EB7C85BF1" modified="2014-11-26" version="1">MMSYQSCPKKTTMLAVVSDHVKSFRSLVYDTCIVSMTSRWYREVLLECPMNSVMLDIGIGTATSLIANRDIIVSKKMTVTGVDYDFAYVRSAQVNVAACGGRLQDMVKVEQADIHAYNKSHTEKFDILYFSGSFMIIPSRVEALRHCVQMLRSPVPKVPGGCNIFFTQTFEKRTFIGQYVTPLVKRMLKAITTIDFGEVTYEDEFRAALEEANVVIVRVKPITDSYYRTQTLVMARPRVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUN3</accession>
    <name>A0A088RUN3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">40S ribosomal protein S29, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_282340</name>
        <name evidence="5" type="ORF">LPMP_282610</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700574.1">
        <property type="nucleotide sequence ID" value="XM_010702272.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700600.1">
        <property type="nucleotide sequence ID" value="XM_010702298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUN3"/>
    <dbReference type="SMR" id="A0A088RUN3"/>
    <dbReference type="GeneID" id="22576679"/>
    <dbReference type="GeneID" id="22576706"/>
    <dbReference type="KEGG" id="lpan:LPMP_282340"/>
    <dbReference type="KEGG" id="lpan:LPMP_282610"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_282340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_282610"/>
    <dbReference type="eggNOG" id="KOG3506">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="255653at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.830.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="entry name" value="30s Ribosomal Protein S14, Chain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_uS14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039744">
        <property type="entry name" value="RIbosomal_uS14_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_uS14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004424">
        <property type="entry name" value="PRK05766.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12010">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12010:SF2">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN99867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN99893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="57" mass="6683" checksum="19238FBDE7D9D165" modified="2014-11-26" version="1">MGHLDQWRSRQKIGMGKGARCCVICSNQKALIRKYELNVCRQCFRENAEHIGFTKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RW12</accession>
    <name>A0A088RW12_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_291520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700758.1">
        <property type="nucleotide sequence ID" value="XM_010702456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RW12"/>
    <dbReference type="GeneID" id="22576915"/>
    <dbReference type="KEGG" id="lpan:LPMP_291520"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290019300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_291520"/>
    <dbReference type="eggNOG" id="ENOG502RYY9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000678">
        <property type="entry name" value="Ankyrin repeats (3 copies), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="707" mass="76055" checksum="535628605DF32055" modified="2014-11-26" version="1">MNGAPMSDEQREALEQRLARLCAAQAATAASGGGSAARVPVSATNGIHHVDVGAPHTEQQDPPPSNRRGGPRSAAAPPPPQMGYDYDDEVEEDEEVESDSTRQQFEDEFLRLVAQQQQQRVDAVSSHELNAASVVQVSATRHADEGVNVVATDKNAPHTCELGDFEALRLAKMGDGVSMKDFGAAFGVVWKTLTDNRGRNALHYAADAGSAALIRLLTDDLHVPYVADEKQMTPLDIAILNGHSNAESDEVYAALVAAAKASGHVDGNLSVTGGDVKTRESLLKAHAPPPPKFVMTKPVPKAAEAAGARTFWSTTSIGSTVTSVQSSSGADMTDSERQAVSDGVCSLDQHGRFEWLRPVTRGTQAPCEHWQVAMALQEDTTTTKMTGVVVAQVLANASLKGPAAKMVSARTVAIANHLSVQDDNRHSGIAVALLNALRIRIEELAGSGQDAAVFFAAGTQLSRPPAAIATVKWYRRAFDAAYVYTSDNAYNVFPDFYNYDEVLLVDAVLKGAIPPSLVQQYMEDLPSWCNLEVTSDEQCALVVSFMQAKAGSAESNVELACVPENVQELRRTYISHPDHRTYVRTNAQGSVTDLVIFRKRDTRKTGKSADSDSGVFVAEVVYALFTTFDGTAKVDHMMLLASKLLSAKLLLVPTMFGITESDLAKSNFDEIVASREYIYAVSVLTRREMDGLCPMPAAKLSLPLYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWI4</accession>
    <name>A0A088RWI4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription elongation regulator-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_272300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPT5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700316.1">
        <property type="nucleotide sequence ID" value="XM_010702014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWI4"/>
    <dbReference type="GeneID" id="22576408"/>
    <dbReference type="KEGG" id="lpan:LPMP_272300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270031300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_272300"/>
    <dbReference type="eggNOG" id="KOG1999">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28901at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09888">
        <property type="entry name" value="NGN_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000074">
        <property type="entry name" value="Transcription elongation regulator-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.940:FF:000013">
        <property type="entry name" value="Transcription elongation regulator-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="entry name" value="NusG, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057936">
        <property type="entry name" value="KOWx_Spt5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005100">
        <property type="entry name" value="NGN-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039385">
        <property type="entry name" value="NGN_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039659">
        <property type="entry name" value="SPT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125">
        <property type="entry name" value="SUPPRESSOR OF TY 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125:SF7">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23037">
        <property type="entry name" value="KOWx_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03439">
        <property type="entry name" value="Spt5-NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="KOW" evidence="6">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="6">
        <location>
            <begin position="399"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="6">
        <location>
            <begin position="455"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="23"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN99609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="693" mass="78081" checksum="BA16F0B6ED6234CF" modified="2014-11-26" version="1">MAEEVNYDELADLLGSNAGFMSEAADGVVGKHERDRLRKHKKHRRDKKRSREEDNAGSSDDKRVKSKYVLDAAESGDSNDEDELSDADLVDDDEEVEDVNYGDRPKRYMFHEGDDKKSVDEMARYYEEVDRHYRRHGDNEDALLTRSDLSSRRLASQFLPREDDPKVFAVKCRPRMSRMLVTRIVNKCYAYRVGRNYEHKKVDLGIISVFALDHVKEYIYVEASRKRFVENVLNGLDGVFRFNIAVVDPKELLQTMETRPSTQKVRVGDYVRLRQRFYRGDLAQVTALHPDGVHITCKVVPREDFVQKPFNKATKRLEPRFFTPRQAVDVREMENSYVWGDLHFDREGYLLKTVSTRMVVSGAQLEQPSIEELARFYNDQREKVERALRAAEAAAQVPPISIGDSVRVTTGQLRNTIGVVENVFTNTNTAVLTCTVPGRVQPIKVQVELSACTKHFSEGAHVVVERGEHAGESGTVVKSWGSIVLLFPDRAAVGAELKVEANDCHQSKLGSVSVHSKGVWQVFDLVSITEPNCVGCIVRLNRSDVDVLTENNDVRTLSYAQVNAVGRDTRQTTDCRENTLSRGAEVHIQKHPWTPIGLEGQTGRIEHIFHRTIFVRCRASPLHANIVALKAECVLLIGGRKTTRRTAPAQEVATGMSADQYAAAAVRLSAGQSRDSELWDESSMMDVNASAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWS9</accession>
    <name>A0A088RWS9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_302610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701284.1">
        <property type="nucleotide sequence ID" value="XM_010702982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWS9"/>
    <dbReference type="GeneID" id="22577314"/>
    <dbReference type="KEGG" id="lpan:LPMP_302610"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300030800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_302610"/>
    <dbReference type="eggNOG" id="ENOG502S1UV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272737at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839134" evidence="3">
        <location>
            <begin position="36"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO00484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="366" mass="39236" checksum="FFF5C2675EAA8B53" modified="2014-11-26" version="1">MGVATVRTRWGRALLPASSVVLLALLMVMCSRANADVIDLPLCAEKHGFAGEFNDHYTIAVEKAPAAGEAVILVARAFPLSFGNLLAQWLYLNVTYRISEGAQLTKTSDNNGILELANVAAGTNIEVRVVRVRSDGPVPFRFFSFYANNPACHVEVAPENSFVAPVPHKLSAAPQPPLTMFFKTVLPPTVNALIVHISADGRTAQQFSTADKVYTSGDLVPAGSGGAVLFAYSPPLESMGLPYCFTTVSVSYGDWQEGDSTRPSVQPTSNSSGDSSASKPPTSQSMSVLRRLLWGFLLMFLVYQAAVSAYNYCVLGERDVMNILPCAESVTTGARTVRLATLRGIGVAQCNKEGYNSLQNPDDPYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RX99</accession>
    <name>A0A088RX99_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein yippee-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_303440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the yippee family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701366.1">
        <property type="nucleotide sequence ID" value="XM_010703064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RX99"/>
    <dbReference type="GeneID" id="22577397"/>
    <dbReference type="KEGG" id="lpan:LPMP_303440"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300039300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_303440"/>
    <dbReference type="eggNOG" id="KOG3399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6407410at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034751">
        <property type="entry name" value="Yippee"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039058">
        <property type="entry name" value="Yippee_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13848">
        <property type="entry name" value="PROTEIN YIPPEE-LIKE CG15309-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Yippee" evidence="5">
        <location>
            <begin position="17"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU110713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO00566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="139" mass="15748" checksum="27856F554795AF1E" modified="2014-11-26" version="1">MVKRLRTRLAAPSGGEGGFGCAFCGAHFCITEDIVSDNFRGRHGKAFLVSRCENTYYGHQEEKQLMTGLHRVRDVFCSNCDQYVGWGYDFAVDEREMYKMQRFVLERQLIRSIAHGQLRGALGYSIPEGNITFSLPVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXF0</accession>
    <name>A0A088RXF0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_290040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIN99954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700897.1">
        <property type="nucleotide sequence ID" value="XM_010702595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXF0"/>
    <dbReference type="GeneID" id="22576768"/>
    <dbReference type="KEGG" id="lpan:LPMP_290040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290005400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_290040"/>
    <dbReference type="eggNOG" id="ENOG502RXGV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276836at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="282" mass="33040" checksum="79F1C7AABD335AFE" modified="2014-11-26" version="1">MQSCVTAAVGHTVGRALRRCATVLPLLPYTTVRYASTVSLPPEAQALRGPDDYRHRDEGSLSTEVRGTVEEMPDLDESEFDELEAASQELHDLCYALIAHLRCADPEANAVLFERRVKRGLRESKPEQYRRLLHGHGDRSLRRRNNYRTQEDFKEAHQLYLQWCDKLLLLLTQPVLDRLVKSAGKGHRDLRTDGVHRYRQPVARATWRTFPHRWFKHAPFEVQQLRADMPESAVLNTRFYRDHATLRYLFTLMEPQHFFRDKIEQRMMALTRSYDPLLRSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXM4</accession>
    <name>A0A088RXM4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_311480</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL43 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701539.1">
        <property type="nucleotide sequence ID" value="XM_010703237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXM4"/>
    <dbReference type="GeneID" id="22577574"/>
    <dbReference type="KEGG" id="lpan:LPMP_311480"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310020900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_311480"/>
    <dbReference type="eggNOG" id="ENOG502R9IB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276443at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000328">
        <property type="entry name" value="Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039927">
        <property type="entry name" value="Ribosomal_mL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO00739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="262" mass="31338" checksum="BE51A0A720FBC78E" modified="2014-11-26" version="1">MSRNGELCLQKIIVSYSPNKGNPAMRQFMATYLPEFYRQYPQVKIDIRPRQWPESSITGVYRDGSEKAYSICFLSSMGINVRFHRLVNEGNDYNHSFSASHLHMQRRSVQGVWNPYLWNYEGTRARHKPPAKWNRKLTEREWDYYIQQYGAQMKAEEDTIADRVRRYTDIPEASTEEVQQRWKEHVMPRLQTDLEYNLSHWKKQHLSGARRPSLPTLKEYSLFSVPDHSSLGQDAIDMLRRREAQREEEWWRERKGQLKPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXQ2</accession>
    <name>A0A088RXQ2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_311780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701569.1">
        <property type="nucleotide sequence ID" value="XM_010703267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXQ2"/>
    <dbReference type="GeneID" id="22577604"/>
    <dbReference type="KEGG" id="lpan:LPMP_311780"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310024700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_311780"/>
    <dbReference type="eggNOG" id="ENOG502SH64">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267139at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="752"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="465"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="611"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="760"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="812" mass="87833" checksum="DCE6D37532D6B7EF" modified="2014-11-26" version="1">MKKQCRLQTVYGGGVMGYRHVARTHKDSIYTGLVPSSRSTKQQLAAADEKLYKRLTASYTNNGSTNSALQHRSATSVSSGVASRKTRSGNSTYLPTYGDARQQCTVEDLDDDVAAAATSEGTAVGLRESSAVLLQTLDTLQTFTPKKDNGHCNGESDDSQNRNGDTSYPTTAAAAVVAAPVPMPTTRGPPSRQKSAGDPSSAPSSCPTRITTDKPLAKGGNANAQCLRKASSFRHQRSSRPSRSESRPGSSVIYVGDLAEVEQRHRPIRRLSSSQNLPVTWICPPTCGQRQRSGRVRSAKGNSRPQSFRAPPTGSPAAQAHAPLTPYRPSSTTTPHKRQNTAQARSSNNEASLSFAHAGEKTNDERRALQYRLHNSPASFSCESEPAMPQVVEGHLSGGVPGHGHGNKDSHQLPSHGSTAQLPELPTQHPPSTPSQHAALSAVPPTLDEVLQRRRVGVKAQPRDPSAAVPHSPHAAYSRSGDGWSAAPRLFHQPSGSALYTSGQHPHYVPKQRQQRLGPNGHTYGVAHDDGDQPHPATDVPNDYKNNSGGGEGFLPALRQAEPSYMRPAGGPTAKRWRAPMPPAERHAFVELFDPLVGGSVSPTLPHQPKRPQQQSQRNQQQPTVELFRSSHRRRRDFAEVKAAPAWPNASPIQEMSPQMLPQRQAKADVASSEPEDMVRPDLDGNGVWAASHGYPAVAPPRTTAAAGNDAYATRAQKRQRNIRKAAERNKRLYHTFAPYMASLRTVPGAGGRVRAVQPKTKKSSRLQQHRGNGSVRSHRQPVDYASLAVARDSLDHLLSRHGFWGEAMTRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXW1</accession>
    <name>A0A088RXW1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Exportin 1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_321170</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701803.1">
        <property type="nucleotide sequence ID" value="XM_010703501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXW1"/>
    <dbReference type="GeneID" id="22577858"/>
    <dbReference type="KEGG" id="lpan:LPMP_321170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320017000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_321170"/>
    <dbReference type="eggNOG" id="KOG2020">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27218at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000610">
        <property type="entry name" value="Exportin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041123">
        <property type="entry name" value="CRM1_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041235">
        <property type="entry name" value="Exp1_repeat_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014877">
        <property type="entry name" value="XPO1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040485">
        <property type="entry name" value="XPO1_repeat_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF2">
        <property type="entry name" value="EXPORTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08767">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18777">
        <property type="entry name" value="CRM1_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18784">
        <property type="entry name" value="CRM1_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18787">
        <property type="entry name" value="CRM1_repeat_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01102">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="6">
        <location>
            <begin position="34"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO01003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1037" mass="118116" checksum="1DD57995C0998E79" modified="2014-11-26" version="1">MESILDFSKPLDVRQFEQVVTAMSSGSPAQIMEAQEILTRFKANSEAFLRVDKLLTESHSTSTRFFALQVLEDTILHRWNTLSTDNQVAIRNFVVSLIVRECTSFAHIRQNRTLLTKMNMTLVSIAKREWPVRWPNFVQEISTSASLSEPMVENNLNLLRLVGEEVFEFGEKTLTSRWVERKKQALAQDFRFIMELCVTVIVNAEDTALLRTALATLEVYVPWMTPEVIFNEQVLQSISRLVVSDGNVRIEAVRCLTEMCSAATSSGATGDQQVRCILETFKTALGNIMNAFPTTHSSVMERVVALYEQGALVDKEYVVNLSLLLIAFLRHYYSSISYDDMLLVTCHEMLVGMSNINEKELFKACVEYWWWLGDHLLRAPASVVKRNLMSKLPRVLSDVRFVLIRRMAKPEEVIIVEEEGELRREHVTDVEELQLYNLMRQALVFLTHLDPKDTRNIMTDLMKRQVDRSEWSWHNCNTLCWAVGSISMALSEQDESDLFVKIITDLLTLFKTMSGKDNRAVIASDVMFIVGQYPRYLRNHATFLSTVTRKVFQFMREKFPGVQDMAVDTFVKLSKQLDTKYAEVNGSTSLASEVAKTWSSITEMLSLQQVQTCFNAAGYMIAAASTEQQRALLLETFLTDTNARFRACTASATAAGATFCHNEEAMVELLHYLRVFSNVADSCGDVFVYEMMLITRDLYGFYRMFSETQARVIADGGEAAVYRPDMKYVRLAKREILLIFERFVSHATQLKFIAESCLPDLFSVVLVDYENAIAAAKEPGALALATACVRTLGRCIENNCEAILDHTFNTTVAIISQDMESHPDFRVNLFKLLQALNAHCFEAFICYTATHEDVVLGMLWAIKHTDYPTMSTGLETLDLFLENVAKSEYAELFYTAYLQRILVDVMVASMDSLHASGFQHHVRILQKLFTVSSMVPVDAPTIGKDVIRAYLLDSLTVIPTLTSTSILSFVDMCYEFFMDDERFRTQFADFLIEVKVWGAEQENRMQEEDERRLREETIPGFSNLSMEDPPVNLFNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXZ9</accession>
    <name>A0A088RXZ9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Phosphoglycan beta 1,3 galactosyltransferase 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">SCG5</name>
        <name evidence="14" type="ORF">LPMP_312970</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701679.1">
        <property type="nucleotide sequence ID" value="XM_010703377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXZ9"/>
    <dbReference type="GeneID" id="22577723"/>
    <dbReference type="KEGG" id="lpan:LPMP_312970"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310038100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_312970"/>
    <dbReference type="eggNOG" id="KOG0959">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="952271at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000012">
        <property type="entry name" value="Protease 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054734">
        <property type="entry name" value="PqqF-like_C_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22456">
        <property type="entry name" value="PqqF-like_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="10">
        <location>
            <begin position="30"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="11">
        <location>
            <begin position="192"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="12">
        <location>
            <begin position="508"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="domain" description="Coenzyme PQQ synthesis protein F-like C-terminal lobe" evidence="13">
        <location>
            <begin position="855"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="445"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="454"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIO00879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1083" mass="119746" checksum="BFD798B9DF10F807" modified="2014-11-26" version="1">MANVAQHILTPAVIRARYSGYVLSSGVKCVIVQDENAKMPAAAMSIHAGQLNDPAELPGLAHFCEHMLFMGTEKFPKEDEFDSFVSKASGFANAFTADCDTVYYFSVSDGSLEGALERFVEFFAAPSFSPGAVAREVNAVHSEDEKNHNNDYWRLDELIRGFYNPKHPRSRYGNGNLTTLWDEPQERGIDVHESLKAFHSRYYLASGATIVVVTSRAADEVLRLIEGPLARMKQGAVPRFSFLETDEPLFTSAALASWTNLRTVRKMRELRLMWPVRSPSSSWRTMPSAYISHLLGHECDTSVLGVLKKRNWATGMVAGSHRVDEDFEVLDASITLTVEGFRNVLKVVDLLYQGLGLSIAHGVNAEVYEQMKAEERLFFESTDVGAPADHCVTLAQNANVTDLKHCWIGGDVVLEDDLEATLAYVRQLTPQNCVVVMQWGDMPSDADMGATAAQDEREESHAEEQRDEDDEEDGDDEGTEDESAEKAAQVEDGSASAEELFLSLPAFAQVRVSKVSRFHKALYQTVKIPEEHVARWQSLINGPYPPELALPSKNPFIATDFTIYPPAAVKEVEEIVSPHAVTYVRRDVGYHRTFKMALRCNVLSPVAYASPLNRLYTRVMHGILSNAITEMAYYATLASLSNEVIFSATGLGFAVEGPSQRLYEFFFAVVRKALSIEVLQGTAEEYATYLEAGVRRLKNVGMDQPYKVLLQMQQKATRHTHYLFSEMIACEPAATYEGYSTFVRQYVESGLLLECFVAGNVRSTEDVRAMLVDPLEDLLEAISVPIPLKAAIPRVRDTYSPRARDGKTNESVLSSFDVLSMPPSNPMDPNAAVVVDIIIGEATPRVMALTNTAMKLISSSFFNALRTREALGYIVFAQSTVDYHTAHALFVIQSALADVDCVYLLSRIIAFLSAVEAQLDTLCTAEEVSKVKRGLIEALEKMPDSVDGDAQRLEGEYLSVSKFESRQLTIAALSTITEEDVKSHFRQFFFNSRSDSRALALYINSARTAATDLLAASGNRRIALPGVRSKQEDGGEALSDASEDTTVLTLPTFSDGCSCVEITSYASVFEYQRGLSVVKCSTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYH4</accession>
    <name>A0A088RYH4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_321150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701801.1">
        <property type="nucleotide sequence ID" value="XM_010703499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYH4"/>
    <dbReference type="GeneID" id="22577856"/>
    <dbReference type="KEGG" id="lpan:LPMP_321150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320016800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_321150"/>
    <dbReference type="eggNOG" id="ENOG502QYIA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275536at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="188" mass="22538" checksum="DC2F02E768EA14A2" modified="2014-11-26" version="1">MAGLDVAWIPFTVMYLLYLIPPTLMEVYSYYSRGGLVRYEDIKYDDSFCPQYQWNRDTEVYYKRFLDRPTSEASNAFFSWLDWSSESYDRTIYILRRNLAKQDGEVSVWWRYIYGPFIFNWPKKTWLRGDDAACRKMPVWGVGGEGRARTEYEEAKAKGFNKNYHYQIMRKIRREQALKAAQERAAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYL8</accession>
    <name>A0A088RYL8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_323340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702018.1">
        <property type="nucleotide sequence ID" value="XM_010703716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYL8"/>
    <dbReference type="GeneID" id="22578075"/>
    <dbReference type="KEGG" id="lpan:LPMP_323340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320039900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_323340"/>
    <dbReference type="eggNOG" id="ENOG502RIM7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053040">
        <property type="entry name" value="LRR-containing_protein_71"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46984">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46984:SF1">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="718"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="587"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="718"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="816" mass="87754" checksum="AA44DB482594ECC1" modified="2014-11-26" version="1">MIFDPCGDLLKDYSAFCESLRVTEREDVYSAIRTRVVQVPPLPADALETPGGAGGDASDAADKHLVSANANAKGLRSSSRTASKEKEKTSSGGKNKTLPKGSLEAVPKRAEEEAPPQLPETPTTTYISLHYPVFCLNQRDMMPLARAIPHCPSLLSVELIGCGLSAQSYMQLVEAVYRSPRVLSVAVDFNQHIGGASCTALPIDKAKHAGVPANARGQGGFVIDPTLRSITSPLLGDALEMSATGLCSFSFASGNSQERPFSLGTATVFPAGGTSAAETATSGDRNGARAVRSDSKSAVMRNRGPSQSEAADASITVSTELQRVGKTGDEDHGGSSSVLYFYPTQYCGVDQLPTQLELQLQEEMEKKGKVDGKRLQQVQTQRDAMRIFNQQNRMEVPRTWDGILFTGIRRLSLRGNGIDDAAVARIVGVLLNNPRSQLESLNLWGNDITDIGATELARLLRHSQDIRVLDVGNNKLSDTGLLELIDTFRMQQVTSPEKVLAARRAYLMRRGATDEGRKAASQPLLVSDIPSYEDLYAYWWYTQQQQQTSNPCTTDRSGAEDGISQVHGNLSLSSTPCLPLPPPPPQRDASLSPSSSASTKRSSSVKSKTTKSEPVPGGYSGGSTAAASATLSSSAARAAMRPTAAFDRDCVRVYHLAESDSSIRVPGNTILEVLNMEENRYVTIVGVREAARRLALREPATTAEVLSMVEVREVHGTLSLPSSSPQSTAGSSTEGCGKRIPGGTHRITAAGSPPALTLSTVIHPPELHCAGLRLRVCAVRCHRESDRRTWPEMDEVQQRLNASLEQWNRSRASSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYV0</accession>
    <name>A0A088RYV0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SH3 domain protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_302620</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701285.1">
        <property type="nucleotide sequence ID" value="XM_010702983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYV0"/>
    <dbReference type="GeneID" id="22577315"/>
    <dbReference type="KEGG" id="lpan:LPMP_302620"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300030900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_302620"/>
    <dbReference type="eggNOG" id="ENOG502S3GU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5340910at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="69"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="258"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO00485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="294" mass="31822" checksum="C327026FB61C9F04" modified="2014-11-26" version="1">MRYFVVVHEFRAEEDVELSVLKGEILSATEGIAQDGWIKVEVATDARRRGFVPMSYLREISAAEAAASMAPPTASAPPAAFASTSPMRTPQHTERETSASAALANTTTSTSFDLGNRSGMLAKGSSPSLQPVRSPETETVHALASSSSIHLTPAQQSAGPVSRHLLENPNAVVDAFMKNEVYFNQLMQRRASALAQMQSGLEEAMTEVAACKDRSAVLARKLRDLDGVVERERQRWMNRVEEEKAHVSRSVPYSTQLAVPVSSGTSPVRSPVSGQSGRLGRSMLDGDIPRELRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZ13</accession>
    <name>A0A088RZ13_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PSP1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_331060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702198.1">
        <property type="nucleotide sequence ID" value="XM_010703896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZ13"/>
    <dbReference type="GeneID" id="22578259"/>
    <dbReference type="KEGG" id="lpan:LPMP_331060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330015700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_331060"/>
    <dbReference type="eggNOG" id="ENOG502SAVX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264671at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047767">
        <property type="entry name" value="PSP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830:SF17">
        <property type="entry name" value="PSP1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="2">
        <location>
            <begin position="801"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="796"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="933" mass="101784" checksum="059611ABB709F8EA" modified="2014-11-26" version="1">MKTFGSTKTTLTSDPRDLTEIPSLFQTFGDQDASSGEDDDSGVLVDTHRAGYGGRSAVTAASSRDLDATSAFSYAQRSDHVARPSSSLVGHAGQGSLSSRRSLHSFNHSSHNPYILLESSDVNHSEQESLIIENSSKAVRRRHSSYSNNTSQNALMFEFTSASTSTFTPADVGSSKLFDSGMVRRRPSQQLQQQSVDAPSTGFWSDGNRMKLSTTDARPISMTTVGTLTCSDKAQNFNVNVKQRVRPSANSTNCSLNTSNSTMPVVQPVSSAPGSTPAVAHISSIAETIPAPLLGSTSNASRFVASGSSTLENHSSSGPSSQKLDRHCIAVTAKVANAVDGAEMEIQKKSGADTGTYTQPHSLSKPLHYQYPPQQQRQQHPQQQQYGYAAQTRPYPLQQQPYIYGGCPSQNYPFIPSQPAYYAQVSASPQQQQQCYSPPVPNSKMTAQQGSTGCTPVQIYGEVPYTSIPQPAQAPYMGDARTMMSTYGYLSIPPIARYTGTVLGSLPDVQRAAPRQGAGSAKVRVQHPPALAETADPTPVTAASAHNKPTKVKTQHADPAQLRHENAKRAVIPTSKVGSYFMPTVAQTTAVKRPTNSSSKKLGKKQDEARFHVNYDEPIRFFVVVKRKREGQRYACSLSVEEVPVGSHVLVEGDRGADIGEVLSHVSIEQMARDCAIVERLRQRAMERMLECKTSILRNTNDDADRVNIDESDLPQLTGEAALEYVMSIKTWPRLIGPTTAEDIANLGPQLEAEKQAYATAKPIVQQLIENRYLQRVARNEAVLAATAAVTEASKTSDAVTAVPVEPAEQSADSASTDNSERRRNLTPLSEEELKMLELSREVTLVDCEYQFTREKITLYVSRPSRNMFVDFRVMQRKLFRTFRCRIWIAYIDEVTHDKDAPESFVFVPFPSMSAAAAAAPTDGETDEANDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZ23</accession>
    <name>A0A088RZ23_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_322710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701956.1">
        <property type="nucleotide sequence ID" value="XM_010703654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZ23"/>
    <dbReference type="GeneID" id="22578012"/>
    <dbReference type="KEGG" id="lpan:LPMP_322710"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320033300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_322710"/>
    <dbReference type="eggNOG" id="ENOG502SKDU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266907at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="620"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="682"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="768" mass="82271" checksum="1517C87420970D74" modified="2014-11-26" version="1">MPSRGGSTVGQRSASPDAPASCANGSARALLRAARTNDARSPLRIRAHVDGTAVSSKRTGADHTEEHAACERLYRNAAERAERRLRASREAQEAEFQANCTFHPSLILVKEGHRERSTSQRARSRSAGAKGVASARGAEAGLGDGSGASLHRATGSSAVQRTPLHSWRQCLAAQAVMLATRERRLAELQRGTGEKSKPSLYPRSPRTKTREHPHTYLEEKGYKGPINGGSKHLLHCVKGKEIPSGTVAGLSSVLPTGPQRGGSAPSASTPPLAGTLLADKPSQQESGSSDASPGSFTTPQRPTPVRSGVQDKRTTDHTSTNAIPEALPHVFGRLFRDSDERASARALIQLMKEHGEDTELCQSKPSRNDVPTSARALYNGQLRPSARQRSPGAPGSKDTATAIALAIGNAAASESTPQHPDVNRPFYADHTVLDALYAEPEALQQRRETRHFLTENDAEAYRHHPCLDARCPVLAEDRARRHSEANSAAAETVRGPRSWFASDAEGKEGIRGARVHFSYPTFAQRQMERDRRRQEELLTALLNEGCGDGRECRFHPALPQATEEMTERNRSYIQVIENAKLAQLLIGAGVNHSGNSLATATAGAATTAPPMSLLDKRTPRARGMWASSSATAGNAALGDRENSAPSAIDSAEGYEALPSVSPPSQQWHGDLYVNTAPEYAVRAAGSPAEQHRSRRGASNDSACVHSTRDTNGRSGAGGVPRTPDMSRFEGALEGDIGALRIAATASSTYLRQLESELQDALKDQLWCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZ87</accession>
    <name>A0A088RZ87_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_323520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702036.1">
        <property type="nucleotide sequence ID" value="XM_010703734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZ87"/>
    <dbReference type="GeneID" id="22578093"/>
    <dbReference type="KEGG" id="lpan:LPMP_323520"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320041800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_323520"/>
    <dbReference type="eggNOG" id="ENOG502RTBH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272130at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="856"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1080"/>
            <end position="1105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1105" mass="119305" checksum="7B188E6338CCFE1C" modified="2014-11-26" version="1">MLNKVIQDIYHLRRVHAVLPDAVLGNTLKNKLLRLSLRPSLQELKHQAQQACTDVNANSQLSSSTSVSRWGHDGGSLSYSPYTINPSALCNLLDSLAYFHLGSSAVATEAVQLVQLSAPSMSAPQLCTTLAACCALGAQTDITATALPLLSTALNSYTGPSSLGADGGAAASSAVDSHRPNNAPLLFSQGNMVLLLMEALQRAGVEEVHVWHQLAEHCLRYLDSFDGRQLCGVIEVLCTEGIDDYPDFFVAAERHITSQPSNYLSPDQLQRVVQCYKDLHQPVVSLLALINAAPLHGEDVERSISAAAAVVAFSRTGGLGSRGKSSRAASSASETARVATPHPSLEVFEGAAITAVTSADAQGVLDLLQKCEQRHVMTARAMDAILERLLALYYPELLSGAACGAATKGTKSASAAAPSLPRRHTPLDLHHLSQSLVAVFEFNDAALFAQQLPTAGSPGDREKASAVAAKPAPATALLDALATELTRWYHNRVLKLVPSALRLLPAPSQPHAFYRSVIDHLRRSSDLSSHEGPLQLRSLIDALLALRAYGGESILVQYMPAIAVAVQNTPRSTQLELTALLAHLPCAKEELIPGVYRQWGSQKRWLRTITEEEVSWALQIMSRSGGLRDSQLLHAVLEYVRAQCAQLPPQRLVEYLHQLARLGVRDLEFFTQTAEQLMRRAVESSPSMALAARGSAAQSVNASLPTSQMMVRHQQWQVTTVHDLCLLLFTFTFVLRDSIRVTQQIISRLKMCVSSAAPRDISLALYSFVKLRVAHNDEVTGQLCERACATLAEFSAAELASMWSSLRCLRHPHGKLRQRTLDLLGASSADASPSWRFADNDCVSLGSALLLTDAPPSTTDQPLVPSQAHEDSAAAGGTDKGEFASFSGSSATARRGLEAALPLPAAFERHYVEVCERLLPDATGQRLYLILCSLSECHTSLNISVKLWEKTLATVETHAESLSTGTLDELSGVAQMEVLAALRRLRACVADPEALATLEVAQDTMLRSSTVRKRSTAATGSERWVAPYCPPRLWSTLRLQWRELTRSAAVLARPGLREVVADIKDGGDFPAETAELKARRRSSAASATKSPVRKGRSAKGVVHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZE4</accession>
    <name>A0A088RZE4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_332370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702328.1">
        <property type="nucleotide sequence ID" value="XM_010704026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZE4"/>
    <dbReference type="GeneID" id="22578390"/>
    <dbReference type="KEGG" id="lpan:LPMP_332370"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330031400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_332370"/>
    <dbReference type="eggNOG" id="ENOG502S6P0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272912at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="47308" checksum="6C34EDE1FA98112C" modified="2014-11-26" version="1">MEGIIQYRLLGNHPAASGRYLTVGFPGETTTTDKIVDQIIQEHRINTSRYKLEVCRLVPGRDASASVPPPPEDSDGTFSLSGAMTVAQSALVSVVIYGSDVLHTYDRLTITVSKRDLADDEASQKEKERLERQRQLREMEEQLLCPTSGIGHFIDGSAGVPTTASKPPQPFCSAAAARPCSTSAAPEVDNLRLQRAAALASQLFPIMKGQRSTLTGLHDAANTHQCVLCLFLAFEEMLTACCRFCVCHNCYASASEMVMKEDQCPVCGIIASSTSPTGAAPVTTLPSSSLTNGGDDSMACRTRGRGAGAEDHSVWKREEGEKKVSMQRAVGVQGAKDTSSRSGHGDGRTTVEAPTWPRDASAVTPSSTAASGLSHAMVPKTAGSRAGSGGDVGHAAASTPFSQDVVRTEERLRSDLDQALSMLDAPDPLSAAAKAKRIVGAELAALCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZN1</accession>
    <name>A0A088RZN1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Surface membrane protein gp46-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_311390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701530.1">
        <property type="nucleotide sequence ID" value="XM_010703228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZN1"/>
    <dbReference type="SMR" id="A0A088RZN1"/>
    <dbReference type="GeneID" id="22577565"/>
    <dbReference type="KEGG" id="lpan:LPMP_311390"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310019900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_311390"/>
    <dbReference type="eggNOG" id="ENOG502SHY3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="258940at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47988">
        <property type="entry name" value="SOMATIC EMBRYOGENESIS RECEPTOR KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839147" evidence="2">
        <location>
            <begin position="35"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="302" mass="32958" checksum="64CD9B01B7DD7043" modified="2014-11-26" version="1">MTPVMLLRSDAQRQRAVLFVMTLTLCFLLLPVHGADSPFTGYTAAQKVNTRKFLQAFVNANPLLESLPSEDFCEWVYAGCTNKGVDLYLDETAVEQLPELPADAVASHVRVTSISISYGKGTLRGTLPATWGGLSRIEYISLYSNSLMGTLPPEWAGMTTAKWFLLYDNHLTGTIPDAWGKLRYMTWACLNDNRLTGSLPAAWSRATRLTIMEARRNQLSGTLPSAWSSLQFISSITLSNNRLTGPLPAAWASAVSLNGVSVQGNGLCGCVPSAWDSRRFMYGIRVDADLLATNCSTANACE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZN5</accession>
    <name>A0A088RZN5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mitochondrial RNA binding complex 1 subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_331820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702274.1">
        <property type="nucleotide sequence ID" value="XM_010703972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZN5"/>
    <dbReference type="GeneID" id="22578335"/>
    <dbReference type="KEGG" id="lpan:LPMP_331820"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330025300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_331820"/>
    <dbReference type="eggNOG" id="ENOG502RNTE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271374at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="CDD" id="cd23737">
        <property type="entry name" value="RESC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058798">
        <property type="entry name" value="RESC9_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058797">
        <property type="entry name" value="RESC9_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26229">
        <property type="entry name" value="RESC9_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26228">
        <property type="entry name" value="RESC9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RESC9 N-terminal region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="RESC9 middle region" evidence="2">
        <location>
            <begin position="494"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="898" mass="97783" checksum="8802A2CB314B765E" modified="2014-11-26" version="1">MENPKLNALISRCRKPILTAAEDVTQTAAALLDLTPYLDARGTRTCLVPLKKLVRHNPETLQAALDRVDVSPEVARDGRRFAAVSRVIPSSKSAVATALWSRVVSTTTRALQASVWAPSDLRVIIHHIHRFSAYDTAFVECAARYAGAAIPCASADDLPALVSIVTSLPELAAHPTRLLDAAGDRAAALAESLTPGAVGHICGQLNRKLWTNTNAVIAFQEEAGRCAEKGDTFTAVQLMCFVARHKPALISDEAVVWLMERITGEELDVRSLENLCSAVVHLPFAVRTALRQELLEFVAFLSLQARELLQQVPAAQGGLSGCDDADAIQHFVSHVLELNVMLRTYPDLQWPPELLAVADACAVSVEPLQEVLLSAESSPVGLMVRLLEAPTSECKRVGLGMLREAANQCQSFPTLQTFRFLLLMGDHGLQDAGTSRYLRDQFAKTASDVPPVQLSVALRCLGVATAVGSTAGAAVRGTSGAGEPRAIVEDAAGDADVDDELERERLDAFLQFCVEVSRKHLSQGAPLRCVLATTESLHRLGCRDTAFFADVAAYIAAKRAVASAEKESADTATAVCVALGEDLLREYPETHAFLLDVAHRGVKGESAMPPTQWMNLHDPSNTLTPLTEQQQESCAIVEEMVRTRSDDVDALVRLAEKYAELLPFARPDDHKYFFGVCEEKVLKQDKLLKKCLDAIVDCGVLSRLSAQTIASILHSLAAIRFEYFASVKRFMSSISDEQWLLMEAAPLVQILTGMDKLSLRIPAVLHRIGGRLTEICRFLTPLDTAQAIHALQALGHNDAVLLAKLATHAAALARRFDELSMAVLFSTPSIHRLMSTPEVAQPLLLQASAKIQSPHQREKISAWVRRSGLPRELIDECTRRLQVMSRDAGPSEVRLRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZR1</accession>
    <name>A0A088RZR1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">RING-variant domain containing protein, putative</fullName>
            <ecNumber evidence="11">6.3.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_311790</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="6.3.2.-" evidence="11"/>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701570.1">
        <property type="nucleotide sequence ID" value="XM_010703268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZR1"/>
    <dbReference type="GeneID" id="22577605"/>
    <dbReference type="KEGG" id="lpan:LPMP_311790"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310024800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_311790"/>
    <dbReference type="eggNOG" id="KOG1609">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266286at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16495">
        <property type="entry name" value="RING_CH-C4HC3_MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000912">
        <property type="entry name" value="RING-variant_domain_containing_protein_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45981">
        <property type="entry name" value="LD02310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0391">Immunity</keyword>
    <keyword evidence="11" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="803"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="856"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="902"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="943"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="10">
        <location>
            <begin position="724"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="530"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="603"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="640"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1020"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="539"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="654"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1020"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1034"/>
            <end position="1044"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIO00770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1102" mass="120988" checksum="B22E681412C5EC92" modified="2014-11-26" version="1">MSRKANEFTSVAAVQAQDPAVRMSASWQNHRVASPAMVQSLAPLGAAEQTSSTASIRSRVVSAEENSTQTPSSTAQRIAGWIEKTQQASRAVTEDAGGPKPVVDDGSPKTLYARDARHESIRLMANHAKDTLIDVDSAKALIPLTIVGSGTTVVRFNGEAGNIINAVVQLKDHRYDKFVKRTNCYGMYLQVELRNHYKLDSNIYSAMGTAAVAAATQAREYADLDTWRDTENSGTLNGIDESSSPDFSSEDERSSRWSNFWDSVAPLFDNSAMCKVLQSVSMRVDKVPVTESYYIILRSTTTQAFQHTEYHANSTEFHPTRREDSPYTCELNVFFDQEPAVRLKWRQLTFALVLPLLVLFLPLPFTMRRADLVQQYMMDSDFAEWMWMPPLLLRKKMVEALKAGVEWVVSLRSAYQQHIMRNHLLRQEQAHQGTGVAQSAAEQEQPSHQTGVQHFGWGTATRAAPSLESQDLTDFSAAAGGDVQVEPLPESCTKHYFHEEEANTSTCSQSNTHSKFSLASIGSGFDEPHDSAYHHRCHQQTGGSSNADTVSPPHSACSRDPLMENVSRPFSTTGCTRWHCQHARESSAACESARAVSVHVPPSPDAAEYWREDNQSGPRARSNGHDVLFTAEELADAGRSLPTPKRHQHAASAPQMSVNDAMQTMSKRPREEEEAMASCEGAVDGAPISGTSAPIRAGIAASPAATAATCGPAPASSAAKSSPDEEEEESFCRICREGEDVAPLIVPCACTGSVRFVHPTCLDRWRIESAKRNLANVNHCEICKEPFRVNIQRSMLLWESSQHILNGICLFLACFVLLVAATTLTHVTLGELSCSASYHQVAYSTMFRFEGLSLTLFVYCLVVLLLLYANLIVYSWFRSQPDVEEYVEEMHIIPPFYTRHNVLLIVLVGVVLLTQAHATGYLLKYLLYKTSHLAWNWETSPLIGGMLFSVFSTCTVTLCSWGRYMYLEHVVNRGRGDAPTTDVVVETIGDSDRAELAADTNNDRAAPTLLTQPITAPATIASSASPTGTAASAAPPPPPPPSSPATPDAAASSPAPPTAPHTVEQQYSAGEDPDYTRHFTIPPDQRVIRAFEYCPPRRKLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZR6</accession>
    <name>A0A088RZR6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Delta-12 fatty acid desaturase, putative</fullName>
            <ecNumber evidence="3">1.14.19.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_333400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.14.19.1" evidence="3"/>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702428.1">
        <property type="nucleotide sequence ID" value="XM_010704126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZR6"/>
    <dbReference type="GeneID" id="22578493"/>
    <dbReference type="KEGG" id="lpan:LPMP_333400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330042400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_333400"/>
    <dbReference type="eggNOG" id="ENOG502QQNB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1461976at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03507">
        <property type="entry name" value="Delta12-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="2">
        <location>
            <begin position="97"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="394" mass="46054" checksum="3D20C632B5B9FE19" modified="2014-11-26" version="1">MKSVLKAGLHKDVNVLVPSAELTIKQIQDQIPPEYFERSTMRSMYYVLRDICQLLVTYLIMYRAVVPVLTRFESRVYEAACADWASWTLVSAAKLAAWNVFWFVQGLNSTALWVLAHECGHQAFSPYRSLNNIVGLVLHSAILVPYHSWRISHGNHHKHTNHLTKDTVFVPRKESKVIDFIDETPLVMLWNMFVMFVFGWPGYLLFNVASQDYGRRTNHFEPSSPLFRKDDAHDIVISDFGIFATLSVLGFCTYQYGAYNVFCWYVVPYLWTNFWLVYITYLQHSDIRIPHYNHEHWTFVRGAIAAVDRDYGFILNEWLHHINDSHVVHHLFSQMPFYHAIMVTRHHIKDILGDAYVEDSRPLLQALYKTWTECVYVVPSEGVSLFYGFNKKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZT3</accession>
    <name>A0A088RZT3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription activator, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_331790</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702271.1">
        <property type="nucleotide sequence ID" value="XM_010703969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZT3"/>
    <dbReference type="GeneID" id="22578332"/>
    <dbReference type="KEGG" id="lpan:LPMP_331790"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330025000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_331790"/>
    <dbReference type="eggNOG" id="KOG0385">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000041">
        <property type="entry name" value="Chromatin remodeling protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000082">
        <property type="entry name" value="ISWI chromatin remodeling complex ATPase ISW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.30">
        <property type="entry name" value="ISWI, HAND domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036306">
        <property type="entry name" value="ISWI_HAND-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015195">
        <property type="entry name" value="SLIDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF49">
        <property type="entry name" value="SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09111">
        <property type="entry name" value="SLIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101224">
        <property type="entry name" value="HAND domain of the nucleosome remodeling ATPase ISWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="178"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="475"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="874"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1083"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="874"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO01471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1103" mass="126112" checksum="D1F4AB6D18594F8A" modified="2014-11-26" version="1">MAATIARRARRRQDLNNTPAFERDMNDMAAHDLYEQLLLSSIRNGSDPNARAVTEVYEGYVEPNYDPVKGASVAASHRQVIQEIFKEREVIIRTLRSSEEHRELSAFDRLLRETEFYTGVREWKGASARGQRSRLYRHTSRDNEEDSTGFDMMHLTDTPSYIRGKLRPYQIEGVNWLLGLFSRGVNGILADEMGLGKTFQTIATIAYLKFTVGMPGPHLVVCPKSVMGNWYREFKHWCPGLSVYKFHVSSDLRPSIIKAHLHPTDRIKYDVIVTTFEMVLDELNLFKRIAWQYLIVDEAHKLKNEEGRAHTALDSLQTSHRLIITGTPLQNNLKELWALLHFLAPRLFNDSESFDAWFDTTSGQQDTNVMSNLHKILAPLMIRRLKADVSTGIPAKKEIYVSCQLSKKQREWYMNVLAKDAEVLNKAGGSVASLTNVMMGLRKVINHPYLMEGGEEGPPFVTDEKLVRTSGKMIILDKLLHRLRADVQGKHKVLIFSQFTSMLNILEDYCNMRGFMYCRIDGNTSGYERDSQMASFNSPTSDYFIFLLSTRAGGLGINLQAANHVILYDSDWNPQMDLQAQDRAHRIGQKRSVRVYRFVTDGTLEEKMYRRALKKLYLDAVVVQQGRLQSKATNQASKEELLSMIKFGAEEIFKTRHEDITEADIDRLLDDGETISNQLTNEAKQQVQMSLASFQLGAEEANIYDFEGVSYKTGAESRILHVKLNSPVSQAELQAQCSQYGEVIKAVLHPNLKEALVYFRSTRGAMEAKAKLPYESSFASRDSQTVVSNDMIAQCIGAGEKLGRGHRVREPVQFFSEADVESMQKKATKAPPLKLPRLPKFHPYQLYNAKRLTELHNTEVALMVRNWKRKYGEKSDVQKGKANNEEGGVDGADDKAEDEDELLTEVEQEERERLLTEGFPTWTFYEYRSVVSALTSGKMDSTDYTAIAAVVGGTKTVGEVRDYVVALLERGEQCIKKFAFVEERIKKAKMRREARENVFKAAKWKVETCEHPEKELTFKTRGNVALDREIFLMAYEAGFKGDNKSELVRGRPQHIFNVWYQSRPDDFFRKRLHTLMKSVQREWEKPADDNGTIPSKSRRRLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZU3</accession>
    <name>A0A088RZU3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_340050</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the prohibitin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702433.1">
        <property type="nucleotide sequence ID" value="XM_010704131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZU3"/>
    <dbReference type="SMR" id="A0A088RZU3"/>
    <dbReference type="GeneID" id="22578509"/>
    <dbReference type="KEGG" id="lpan:LPMP_340050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340005700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_340050"/>
    <dbReference type="eggNOG" id="KOG3090">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275637at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF1">
        <property type="entry name" value="PROHIBITIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="8">
        <location>
            <begin position="37"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIO01633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="292" mass="32285" checksum="D7555214BA412AD8" modified="2014-11-26" version="1">MAAEARKKMNAYGGFGNIVGMSALVGVGCVSIYALYKSVFFVPGGFRAVKFNSITGLYNRTYGEGANFAIPFLETPVVFDIRNKPIEVPTASGSRDLQTVNMAVRVLYQPNVENLHHIYRHIGINYAETVLPSLINEIIRAVIAQFNASDLLIKRPEVSHRIGVMLAERAKRFNIDITDVSITQMSFGKEYTNAVEAKQVAQQMAERAKFRVEQAEQEKQAAILLAQGEAEAATLVGNAVKRNPAFLELRGLEAARTIAKTLRDHGNGRYYLDSDSLYVNVKDLKIDHSGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0E8</accession>
    <name>A0A088S0E8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WLM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_321390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701825.1">
        <property type="nucleotide sequence ID" value="XM_010703523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0E8"/>
    <dbReference type="GeneID" id="22577880"/>
    <dbReference type="KEGG" id="lpan:LPMP_321390"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320019500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_321390"/>
    <dbReference type="eggNOG" id="KOG1558">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="261960at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053000">
        <property type="entry name" value="WSS1-like_metalloprotease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622:SF1">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WLM" evidence="2">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="381" mass="40875" checksum="CB6652A7FBD3D04C" modified="2014-11-26" version="1">MEHILQRARVLLPRRGWRIGLIKEFYPRGPSLLGLNVSAGREVCIRFRVPGKKSEFLPFHEVLCTALHEFTHCAHSQHNRSFWNLYYDLVKECEALEVTMIQQGKQLYPDISYTPMGSSSTASQKSRAGRRDRTVALPGSSPGGRHCLGAGDAGGGGKARGGGMHTCSRTAAQAITTAGRTTFSSSPSAKRSTAFPGKGRRLGGSGVHQHGTLVGFAPTRDALRRILADAAERRRVQQPPSAVTAKLDTGSLVLSTDNRTFSQDGGQSDVDDNNAPDCVPQSFSDELNGDSWRCSRCGFLNDGDVAGSCAFCADCNDGDDAEAPSLKQPPLDSDHPPLEISRVVVSSVTASNTVPEQPPPPQQGEGTSKEKCILVSDNDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0M9</accession>
    <name>A0A088S0M9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">1-acyl-sn-glycerol-3-phosphateacyltransferase-like protein, putative</fullName>
            <ecNumber evidence="5">2.3.1.51</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_322060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.51" evidence="5"/>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701890.1">
        <property type="nucleotide sequence ID" value="XM_010703588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0M9"/>
    <dbReference type="GeneID" id="22577947"/>
    <dbReference type="KEGG" id="lpan:LPMP_322060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320026200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_322060"/>
    <dbReference type="eggNOG" id="KOG2848">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="417078at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434:SF11">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="4">
        <location>
            <begin position="89"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO01090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="287" mass="32372" checksum="EDD7927CE32AF679" modified="2014-11-26" version="1">MTEKKHPNKVLRLLCTVYLILSLIVQWILVWVVQALFIVVSFPFTTSEFRQDICGHIFRKVSFVGMDLLNPFWRIHVLNKFPKVPNKKVIVMLNHLSGADPFVSIRSLLPRDGTWIAKGGLFRVPFGGWALYNSGDLAVHFRDKKTSFATVKGTVGPMMENARRRLRRGRMLCVFPEGIRNMNPDGPLNPFRLGFFSLAVDEGATIVPLALSGTEKLWPRGSALMDAADAYFSFGEPVDARNFKSAEELSQHVWNVMTELREKHPDRVELHARRTNAEAASPAAPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S190</accession>
    <name>A0A088S190_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gamma-glutamyl phosphate reductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_020510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009371">
        <property type="protein sequence ID" value="AIN95231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698196.1">
        <property type="nucleotide sequence ID" value="XM_010699894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S190"/>
    <dbReference type="GeneID" id="22571861"/>
    <dbReference type="KEGG" id="lpan:LPMP_020510"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_020010200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_020510"/>
    <dbReference type="eggNOG" id="KOG4165">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="263439at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063:SF8">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063">
        <property type="entry name" value="GLUTAMATE SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="659" mass="69361" checksum="28754D6273C2C6F4" modified="2014-11-26" version="1">MLRLSAPRWLVQNILHDIQAAAESRSVMATSSFAQRRSFLAALSEELHRHREYIIRANQRDCDLFGQQQQQRGTPSVTIPPMLPSTSAALSAQSSASLHGDRTGCSPFLGYPGHRVGDVPAVSVAAGSAAVSTPGANAAGGSGASSPRRQSSLEYVVSTSLVGSQGQRGGGSTAAGGRIAASSTGAGSTLGETAAASQAANTSCTAIPASHSEWGAGAVSASLQLVSTATLGHATRTEAGGGGGHLLITPDNHFLISPLRLDKLHTTIEYLLCQPDPIAMPPSCWLRDYAEGENRSAGDPLRGEDSSDAAPSHNSPPPPSARRPHEDRGRCTRRTGQLEVYELSVPLGMVGILSRFRPRISIDAVAMGLFAGNTVLVDGGVSLYYTNMALVSTVRRALATAGLPPSAVVCVENYDAAHRSTSEWLQLSGYVDLAVVCGPPKLYQFASQHSTIPLIRATGQFSSIYVDQSASFEVALEVILNSKFQKLGAANAVTTVIVHSDFPRYTELLLALAADGAVLLGDVTAQERVPDCVVELASEEEYQGLAQYGLRDAARTLCIKTVDTLAQALFFIESFGSKQSDCIVATDPEVCATYCRQVDTAVALVNASTRLSSGVPLGCGVDFAISTSKTHHRGPLTVEMMTTRKLVVRSLSTYHGALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1K6</accession>
    <name>A0A088S1K6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_040340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="AIN95361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703683.1">
        <property type="nucleotide sequence ID" value="XM_010705381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1K6"/>
    <dbReference type="GeneID" id="22571993"/>
    <dbReference type="KEGG" id="lpan:LPMP_040340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040009300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_040340"/>
    <dbReference type="eggNOG" id="ENOG502SMKC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267053at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839188" description="C-type lectin domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN95361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="28122" checksum="8915F1DA2FD4AF23" modified="2014-11-26" version="1">MLAVCLAAAVCLAASVASAGILFAPSDATLPLTSFDQLQAICTAAQPGSTPVAMYATTMTSLVASLMQDKKVTQAYVSAYLNADRKWLWYIYEAGQVIETLVNSSQWASGNPTGAYTTYRYAAYSTQDRGLISSTGYDNYPVICNYEDRISYSPPEKKFPWWAILILVLSVAAVIMIFIVYCCCCKKKQYDDADEDSELATRSGSFRSRGSSHAGSSKSDGSSSFASSRRSSFSESESQCDGSSFASSSRRTSYSDSTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1N9</accession>
    <name>A0A088S1N9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_331890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702280.1">
        <property type="nucleotide sequence ID" value="XM_010703978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1N9"/>
    <dbReference type="GeneID" id="22578342"/>
    <dbReference type="KEGG" id="lpan:LPMP_331890"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330026000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_331890"/>
    <dbReference type="eggNOG" id="ENOG502QR8K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="417678at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36960">
        <property type="entry name" value="SI:DKEY-32E6.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36960:SF1">
        <property type="entry name" value="SI:DKEY-32E6.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO01480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="389" mass="44107" checksum="2A3095B6544907A5" modified="2014-11-26" version="1">MSRQLLQRCSKKHFVIHMDINKTIIQVDQAGGRTMDDVLNSNVAANTYGYIDPTDNQWRPLYGPSDAPVAQPDTYSGPIMSYDTYIDSLYCAPPGMQELSKAERDAVWRTVSNLRRQATRKFTFPGEAGEAYAPLVDLQRQHLGHSDGYYNIIPAFFHMINTLSELSLQFTLIFRTFGSDLSAVLEEWRSFVFGMHACKPSGPVLQELKENYVEPLSGSFFRQADDIYICYGPRVSLSSYFTSSFQETDPAKVLEHLHQVPGCTSACKTSFADLKDHLVAYFSRSKNVGGLVDYYPSWAQAAEHRTGGKVYPISQNDPNYYSVFFDDNIFIGSEHSIVDIRETHGAKSIVDMEVERKYCVPVNAFKAIVDKEYFVKELCTCLRLQNRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S257</accession>
    <name>A0A088S257_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_351490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703086.1">
        <property type="nucleotide sequence ID" value="XM_010704784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S257"/>
    <dbReference type="GeneID" id="22579178"/>
    <dbReference type="KEGG" id="lpan:LPMP_351490"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350020700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_351490"/>
    <dbReference type="eggNOG" id="ENOG502SMNH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267336at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="385"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="582" mass="63093" checksum="970B8B1BB6EDF02E" modified="2014-11-26" version="1">MHDSRRVSTMTTSSGDAAPLSVEARVAAVRQRRLAREARAFGAAVVAVSASAKPTSLPHRLTERERNNVTPPCQPHTMPSLPLQPIPLTSMFTMTSPPETSPLAVRSSVAQFALESSSAKGVSKVVEAVGVDTRRPPRTASYAASSTETSDRTTYYSNGSSSAATTERPAPDGRIAALHRFPSSTSSAFTAAFSESVSSKHSFTVVSVCDSSPSNPIRHAPMNAKSDSTQRGRGQCAEAEMPSPPYRLIDDTRTARRLFSTDTESSTYVTPRGTVVDTIRITNPENNKGRHFFPTFSVQRRLMATVEEDSGRCTSIASTPETIASPSLMKMQTVSPKKTISSTGPSTSSRGIDKRTDIDASHLCSTDVVSLSRAVPSLRSFAPFSRSSTTRSQRSCASPQPLSEDESWPISRDSIEAGVCLRQDSPHTRRAQSTYREGSLSGRVTSALSALPPGNRNERPRSASACRDTTFRSPFSAKMPSFSSFGHRMSPTVANRAAPSSCHTRTSSLLLRSAVYPVFLATTTRSRYNLLDDTTTTSATESAERDIITEELAMQRRLSRLKLELAQQRVEWRRRGGHTSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2C8</accession>
    <name>A0A088S2C8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amastin-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_354250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703358.1">
        <property type="nucleotide sequence ID" value="XM_010705056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2C8"/>
    <dbReference type="GeneID" id="22579453"/>
    <dbReference type="KEGG" id="lpan:LPMP_354250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350050600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_354250"/>
    <dbReference type="eggNOG" id="ENOG502SMJ0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272410at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009944">
        <property type="entry name" value="Amastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40741:SF1">
        <property type="entry name" value="AMASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40741">
        <property type="entry name" value="AMASTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07344">
        <property type="entry name" value="Amastin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="199" mass="22057" checksum="03D1CAF6E74EC36E" modified="2014-11-26" version="1">MLFIRFILLVLILLFFVIAFIGTTPLPLYSNKITNYNQNGKVEVSLWFIKVGTVSVTGENVTEVPTSYPVRINYAGCEEFRSVFRSMQAFAIGGTVFGFYAVLVSCLQCFCRLKVKLPLFMFLFLAMLCELCVIVIAGVAYGKEFCPSLATDGNLTTIIFKGAGYKLDSAFSLHVVALVGYTICLIITPFTQQLWCGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2D5</accession>
    <name>A0A088S2D5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_060670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703948.1">
        <property type="nucleotide sequence ID" value="XM_010705646.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22572273"/>
    <dbReference type="KEGG" id="lpan:LPMP_060670"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060012400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060012500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_060670"/>
    <dbReference type="eggNOG" id="ENOG502QTSV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="250979at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="878"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1317"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2078"/>
            <end position="2110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2162"/>
            <end position="2335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="586"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="890"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1330"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2095"/>
            <end position="2109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2162"/>
            <end position="2184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2190"/>
            <end position="2206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2227"/>
            <end position="2246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2253"/>
            <end position="2264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2269"/>
            <end position="2279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2281"/>
            <end position="2299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2314"/>
            <end position="2323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2324"/>
            <end position="2335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2335" mass="254238" checksum="4080527EE882D639" modified="2014-11-26" version="1">MRRHRLHASLHYLSISSGVEVPECAGGAYHLQERPPLRHSTVAVSAAAGRGNHGSYLGRSRTCASNVRVSVFPSVLLRPASGTDSVSSSCVSSPDGRPSSSPSSATATRASPSVLRHDAAHLRIQQYEPFNRLLHRYIERGHVAYATQRLLHHPNAPAPAVLLDMILRHRVPAASFVCQALLATMHTTRRDRSTAAAAGFALDRVAVRLRNDEKARVLYQTPQVRALLLEATLQESLFDTAVDVVMDMPVEWITPHAWSQLVVMAGQSKLPHSHLLWKLLRLREGSLSTLRSSSRETRASAQPVLTRAGESALLGALRQRSLSTAPSAVHLSHMAATVDASALEAPELDAIAVPDGALDTRACAIVLAPAKSEVGGALLTDSTVAGEALPVDEEGEESAQLASETNEGQSSATPVMALVPTGTVAGGDNGNRWCALGAVELGYAAEHYNGDASPAAGDFRASGAAGTLYSHSSFQALLADVEREGVQAGGSAEASPAVRARALWETTALRMINSRHGIAYGLDATMTAQVLLRCGVSFAAQASPLLALHVLRRYLHSCRLLRDQVVAAQRLVEAQLSAVDERSTGRIPRATTPTTTAIENQTRSRHHSERASSDLYPRLSRTVMPHPAPFLVFFKVMREARDVLLHAVYGSDEEDEEVATLSATQRYRGTAAAAAGRAHASLPMVHWELVWHVFQQLNRENPLWYTQLGPQEAGDLCIDAMEVLCHGADPWLTLNVARRVSARHIIDGVDMSLWLLNRLDPSHHTDEAREVARKLFRWLLVDVGVHVQPPLHRHLVPAARTLIRLGLQEELSTLYNAVIDNVVLFTPEHRDAFLHVLRDLICPACASVLPENDVYVDRVCPNCMEVVPAKDTDTIPSFRLSAEHVERQRAQRKQRRQRTRQRLSASVRRLQQDGARGSGSSVSLFHPPRDAADILRWHLQKRDSTEQGGEDGALDISPSSSLLLAASAAAGAPLVPGVSVSNELALFPVAGEAASGAQVLDVRAAMEESSRRLELQRAARRYVLAQRGVCDDADGGDGGYAGSSGGVPSATLRVTYGTLPTTLPVSAQALDASTLKYLSTAAKATPGSEQAVDGAWVCVWCQEDNTEWCSRVQCNACRAETGPGAPWRRFAYTEASGDIMLELRGRISNCEERPVDAIVAGYLLMVYRRIFQLRATPADQDRLLRLVEVLCQLQERVLAAYVYTRLIPISQRRLGMPLSSLAQVFGQEMSPTYQALRQADLTRPGADGMFFEAIFGAQTCRICFGQHDWHLCPIVTRNFAASESATGEDRVRTAISLSPEEKQRAVLERLSQRIRHAATSLSPSDEELESATSSSPSSPSVLLPPGRPCVRLVVDAYTAFVSSPFREIFAELHSSDANCLSLLLSRVQQYRRAAFVLCHVPPPQRAMEAYLRMVHYFNVTEAEALALLEPPPAPATASKGPAASGCSSAGYPASVVRHVNFMQVTQTCCMCLDARHASHTCPRLDEWLKRVQRLALSGSSGSNGAAGAPSSAAATTLVDIQGDARLRRRLKAQVDGWTTAGPERLHAFYRYLIVHIDLLRPMALVSTGTAKPSALRRADFDDPLVYAVNKTIVKLSAVERRSETYRLYSHAPVECVSVATTAAVLRMNGFSEGSAQTLLTHASSTEEGPATRSDSDTFAGSRCSSVLLHASLAARTAAVPVRQCCLLCFSPDHAFVECLELSAASTEVERLLIVLRNVAEIACVPDGIGAAAAYVYSEYNRGRLSAEMMRSHPELVRELLMLTRRCFATRQLSHGVRVLRRIPVEMVPPDTAYVDLWRAAGLPADEVEQKRVQLLALLDAEAVQPSLDPLPPRRTYTNAFLSQLSRTLHDDLCRHCYEHGHTIATCPLFHAEVSFGRDYVAAYRMSMMSEQLDRAWQEAYLLKLVDFFATHFLFMPFHIAGVANALNAITSMWSFRGEPGIALRHLLRIPPAYRRRQAFKHVLHSLRVPPAEITKLLSDFYFAPDGNATAAQQQQQKGSIPPSTSGYHAQQQQEVVMAQHLLLPKPAIRDVARKQIFDQVPAAVAALEGSEERMAEIRTHHERQGGSGGGITAKVQERLSQQQREQPGRRSTEMSHASSPHAAASFHSPVLRRIMQSGDITQLREDFDPILTELEDAVGMKLGSRHTLFTSTAEIFSTAAATAASAPPSPPSSFSSSTPSSSSSGKGSGTRMTASGAAPSSPTFPQTPEAEVVEEVQTHYAPTRFPSSRQSTTTRVSTTSSADATAGVAPFSERTEQQVREGDISKPVGASRGSSSSDSGGDGRSDCRDARGSRSNRDRNPRHRSTSQWSSHAYNRDRDGCSRKHDKNRHHNRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2P3</accession>
    <name>A0A088S2P3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NIPSNAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_353540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NipSnap family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703291.1">
        <property type="nucleotide sequence ID" value="XM_010704989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2P3"/>
    <dbReference type="GeneID" id="22579383"/>
    <dbReference type="KEGG" id="lpan:LPMP_353540"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350043300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_353540"/>
    <dbReference type="eggNOG" id="ENOG502RZV5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262843at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000073">
        <property type="entry name" value="NIPSNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012577">
        <property type="entry name" value="NIPSNAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051557">
        <property type="entry name" value="NipSnap_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017">
        <property type="entry name" value="NIPSNAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017:SF17">
        <property type="entry name" value="PROTEIN NIPSNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07978">
        <property type="entry name" value="NIPSNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIPSNAP" evidence="2">
        <location>
            <begin position="19"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO02491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="200" mass="23020" checksum="B2C1375B237221A7" modified="2014-11-26" version="1">MLRLCARRLGNAKSASHVYELRTYVLAPEKYDSFHQLSMKYMPQRPRIGSCQGCWTVQLGGVNQYIQIWGYENLKHRYDCRKQLEQDQEWFRTYVKPADDMIISKSNALLRLVYREGNASTQSYKYLIQVSPHKEVELSGPSAILAATFQVIVGEEEGKYIHLVKGHNLDDVIPVTPTLGCSSKIMGPVRWSSTMNCLWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2S0</accession>
    <name>A0A088S2S0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_354150</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703349.1">
        <property type="nucleotide sequence ID" value="XM_010705047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2S0"/>
    <dbReference type="GeneID" id="22579443"/>
    <dbReference type="KEGG" id="lpan:LPMP_354150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350049700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_354150"/>
    <dbReference type="eggNOG" id="ENOG502QQ22">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5587616at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:002206">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051730">
        <property type="entry name" value="NASP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081:SF1">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN NASP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="371"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="175"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="371"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="422"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO02549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="433" mass="47541" checksum="EF1876DBEC1E7932" modified="2014-11-26" version="1">MSATHHPSLMHTCEATPQQDEAECPMPKEEVAGHVAKADEEASERGSQSEEASSTSSEEHEEVEEGEEEDQDDDEDATFQFATDEEAEAQRQTGITAYNEGRYEDALDVQYRVVRHFSNKYGSTSAKCGKYFLDYGLSQLRLLQRQTTVDDVLRPRDEDTLMTCYVNLEVARVCLQKLEAEVGEEDVEVELALAEVRNALAQLSVEKEDYDAALREYETELLHYRCLQDAAPEEEKLTVVPAGRVVGVLYGIADCFMKEGDFEGAEERLRATLDEIKLYPAGTIAASLVAELEDLLADAIGMKGGKFQEIQKAIKQQFAAEAEQIPTPQEFFSVDKDGKHPFLSAVPGGAGDEVTESSYLSMPMSANGQALATNEHSNSLSVSLFPPQGSRSGTPSGPVQHAVVRKKQKRTGDDSLSSAQPENKRPRAESASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3C3</accession>
    <name>A0A088S3C3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_090750</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ACBP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN95991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704313.1">
        <property type="nucleotide sequence ID" value="XM_010706011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3C3"/>
    <dbReference type="GeneID" id="22572645"/>
    <dbReference type="KEGG" id="lpan:LPMP_090750"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090013000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_090750"/>
    <dbReference type="eggNOG" id="KOG0817">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF62">
        <property type="entry name" value="ACYL-COA BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="4">
        <location>
            <begin position="910"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="732"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="791"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="738"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="807"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="828"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN95991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="997" mass="107897" checksum="7DDA7CC9F42E4304" modified="2014-11-26" version="1">MMRGGAAKGAAVQAEFTVLRKPTEDNKYWYTAVHQGEPVTFRVLDDNGIDPMDGAGYIKARVQAMQKHVQEACIDIAAENAYRAVLVEVSLMDDPMAIPEETQRNVDCAVDLWYPLHVALMTANKSAAQALLQFHMEHALDAMTLIANTPSTVNRPDSLPAAPASGDGALHPPGDASTASISPIAVTPILECQVRRELGGAVVLLGYFDGRIRLFSSTAALASCPLSPVRAASPQVEPISGSPVAIEGAVVGRCHCSTDTAVGESTLLQNLCKHNDALLREEEALFEDKGEEYCLRNILVVMRPLLQSVVLEIKRRAQCTTTTASLSSQHHNHRHKASGESATPVVPESAVDFLHNYCNSLSMLPQHPPLLMDGDTVFEVCNHGDLALLAKVMDTFDGCLAPVLRGQTLLTDRSAGGRSVNEAQLNAVGVAALTSATPPQISSRNPSSSFIGAAPCCSSSLLSLGGDTSAHTIAGASCKGNVGRHSHTLSPEPFWWSCPPQNVHRLMFVAVWIGYREVVVESSGSGRRRRAVSISNENRLMMTTIRQLQESRAAAQKLDSTIWSGHLITITKLLSRECSLEDYMDFVEEGGYFSFTSPHGFSGVFISVLVSGAMAAALVQEPAMLRMLRRKVETLLVDVPGRSSLLRTYVMGSPSTHAERFRDLWLDAGCHRVANTDGDNTETNDSDHADGIGRGGLRLVKFRSRVELLYYAVVEQVAAAAEEAWKVHGAEGGHSIKTTGSSATPSSSLWPSGATKTESLTALQGWLLMWTNFLASLHDRTSHRGNLSYSSASSQILQQERQEQSQHIPNSGAESSLTTDGTSPPLTPTTASHHQHTASTEDLFSDDANETVDIVQRVYHTLVERLERGQEPLPALRRVLFPNGTNDMEIGTPTAGTSVHVGETLPVSSTDQEFAAAQHAFAAAAEKESNEVKLKFYALFKQATIGDVNTNPPGIFDFAGKAKWDAWSKLKGISSLDAKRMYVNEYKMMMSLRKPHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3I1</accession>
    <name>A0A088S3I1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_091320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN96046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704368.1">
        <property type="nucleotide sequence ID" value="XM_010706066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3I1"/>
    <dbReference type="GeneID" id="22572702"/>
    <dbReference type="KEGG" id="lpan:LPMP_091320"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090018600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_091320"/>
    <dbReference type="eggNOG" id="ENOG502SC5K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264283at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="348" mass="36539" checksum="DC1122E182808975" modified="2014-11-26" version="1">MRGAPPPQFDEAASESDVVVLPSSSEDSPTPAPRLAPAQVAQWTLKDVENHIFFVVWVCGIPVHLRYIVHLLEHSAVNTGGGRDQNPHFGSTKESLTAMAQADVLAPVCRRAAELRQVLSRWPITITLSGLQSHASFSEVVPLGVLSQVPKHEDDAIRHVVGGECQEDCGSFKLTAPAFSSASCCIIQAGAVTPAERFDNVAALALCSPAERGGVSPTSAPSATWCGQAYWTALTQAQQWIAEWPSFSSGSLGHTNSLGGTGATSASSWPPLRPACTLSASRRKHLRGGGAPITDSVVVVDADEGETQESAGGAGSTSSTADDIVPNSKVQLREEAEVVVIDSDEDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3J6</accession>
    <name>A0A088S3J6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_356910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703619.1">
        <property type="nucleotide sequence ID" value="XM_010705317.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22579719"/>
    <dbReference type="KEGG" id="lpan:LPMP_356910"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350078900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_356910"/>
    <dbReference type="eggNOG" id="ENOG502R15E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="62528at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052634">
        <property type="entry name" value="Sperm_flagellar-bone_growth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14919">
        <property type="entry name" value="KPL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14919:SF0">
        <property type="entry name" value="SPERM FLAGELLAR PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="833"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="835"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="845"/>
            <end position="858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1358" mass="150377" checksum="491E0DD329A80FDC" modified="2014-11-26" version="1">MDIKDDYRTSVARARKEERDSRERCRQLRNEYQDDLLKTRIAQFRDCFLSDARFHLTRRSIAEESLMLTLRNTAACWSKVCERTITRQLDIESAKKHKVLRDAAFLESIHQREVEAQRSVEASDQSRWEDLNSRYTAQLLGDRNAAVSTTLEDVMKRTAECLSEIEASHVDSAGAKLLTAFLVNATLWRRTSVDDTTAAVVREAFDQIFHGSPYAQSSPAFLALLEFCYRQHRTTPPLAQVLRLCSVPILVLDGPKYSGKSILASFLKSKYRFLCISDETLVQRALQAASDEAVKEEGKGAGDWAPLGRCLRQVLLGGGTVDVQLMTEMLCLQLAELRNAREGLSYDAILLEGDVRSVDAYKALAQRLSSQPVHPHLKIAQRWGLSTTADVDDGATNAEAAAENLPSLLCLPDHLSTECDTPAKQEPKARPLKKVDLATLPPAVLPEVEDTQSAQEAERTFVAQAEQELASLPTVISGVLHISCAPEEVFHRFAGLRTDCETGDRYHLTYNPPPQERLPYMVPLGRPDASSVELHEAVFHHIEGWSATRRWLAQQSEGSIFARVYELAGDGPAIEVQQEALEAVNQIISNFRISQQLLDERDASAARLSELEATWASQKVAREAERLRLIELYTEKGAPIPPVLQPTVVKTSSSSATKLSAAAASVILKALANFTELYEADYAGTWRRTTQLVLLFLRYYTRVESQMGLYWERPDDKQAILHRFQRSFDSLPASMRVLPACKAELHLSLDALNEALHRCIALRDVEARGLLDTLTSTTSFMRSWQTLVCQGFTRLLQAEVDRYVFAMHIFSFFLGAVTGEPLRFDDGEVDMPLLSMNTPDRPTQSTSVAADASPSSSSGGKPAKEKRAAVAKKGHKAVEEQSEKIAEDQLAEVVQGVLNGFSSITDKLKAAVEAQGKAPKRAGGGGSGGNSSTSNSLAAPAVILAIATAKCYGFMEAERAAAASRVAAIHSCGRMLLKEAEAHARKMRTRMEAGLLKVMEQEAAAANTAVYILRGCVESEKKSPTMHLGCTTFAVLQERLPRASPSAGSASAALVCASRMPMKINSTFEERCSFLTDVPLLAQLREPQLTLHPGLTAARLLELVQQLRCVAPDYQLSRFDFLLLVEGSDYAEAAAVGLDAAHMVKTREELFSTFDPQCTGFADWRDVVVHLLFWVRPPTAATAPAAATAQNDIRDISLQDLLDTRANLGVCGLTKEQFFDMSFFFDRYLDDALVEAYTHILWCTFHDATNHILQPYTLLGFLCADPQPIRGVQKAFRILSAPNAEGRISLEEMDSLCHLKATSERRMAQLDPCCRMNLRLLFGTAATCSFEDVCASPIGRKMLNHADLFRRRQFFKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3P2</accession>
    <name>A0A088S3P2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Spindle assembly abnormal protein 6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_356830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703611.1">
        <property type="nucleotide sequence ID" value="XM_010705309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3P2"/>
    <dbReference type="GeneID" id="22579711"/>
    <dbReference type="KEGG" id="lpan:LPMP_356830"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350077900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_356830"/>
    <dbReference type="eggNOG" id="ENOG502RGE2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="49058at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="CDD" id="cd10142">
        <property type="entry name" value="HD_SAS6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.210.20">
        <property type="entry name" value="Spindle assembly abnormal protein 6, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032396">
        <property type="entry name" value="SAS-6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038558">
        <property type="entry name" value="SAS-6_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34230">
        <property type="entry name" value="ASSEMBLY ABNORMAL PROTEIN 6, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34230:SF2">
        <property type="entry name" value="SPINDLE ASSEMBLY ABNORMAL PROTEIN 6 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16531">
        <property type="entry name" value="SAS-6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spindle assembly abnormal protein 6 N-terminal" evidence="1">
        <location>
            <begin position="29"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="197" mass="22432" checksum="C480ACA5B664E692" modified="2014-11-26" version="1">MADLLSQLEQDFIAIQQADPSLADGSRLVYDREVPFELRAMRDGQSSAGSLEPMKVKVLTTGEERNLASLRVEVATESDIFFHYTCIINDQGFLRLREDQNLVCEFSEFLMTLLKMFNRCIREPGRFIAALLLGDDGTANLEFVENLEYKLVSVLVLPFRASPPEVVREQAQYRYSAVRARLDLVTEQIKHASPARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S5I2</accession>
    <name>A0A088S5I2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribonucleoprotein p18, mitochondrial, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_150320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697409.1">
        <property type="nucleotide sequence ID" value="XM_010699107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S5I2"/>
    <dbReference type="GeneID" id="22573448"/>
    <dbReference type="KEGG" id="lpan:LPMP_150320"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150008200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_150320"/>
    <dbReference type="eggNOG" id="ENOG502QUT8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN96756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="187" mass="21333" checksum="9940DD9EF80F44EE" modified="2014-11-26" version="1">MRRLSSQLICTAAAARFASAGGAKKYDLFGYEVDTNTAPWIEKVKKCQYYDEAGEVLVSMNVKNCPPDLETYNATLQKIFEAPSKQDKPVDNESKFCAMMDLMEEMQHRNKVKPNEESWTWVMKECVKSGQFRLGYCIARLMESEFKRTPEDLVKQNEANAMKAKADGKEHPSALAQQQSLFEIKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S7Y1</accession>
    <name>A0A088S7Y1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_201770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698378.1">
        <property type="nucleotide sequence ID" value="XM_010700076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S7Y1"/>
    <dbReference type="GeneID" id="22574386"/>
    <dbReference type="KEGG" id="lpan:LPMP_201770"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200023100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201770"/>
    <dbReference type="eggNOG" id="ENOG502QWGP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="242583at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1008" mass="111808" checksum="82703992F72C26A1" modified="2014-11-26" version="1">MRRRLAVFVFSEHRPAKTASTLSHIPVFYVPLRWQSNYESDPRSPRSGTGFHSGNARLPQPAEATTSKAETVVKEATIPDRMILDWSGGSAYYFSEEENTRLFPSNSCPVSDGGSRGPAGPLSPPHVGSSNSDGGTKGDIAEPTLRAVIHGVARNFSIDLTIPPVRREEVERWKLDGYLFCKGFNASGISAYSTKRYNQLLPSSAMVTYLGPEMRKLDQIHRQKGFFTPSEVAEVFIPLVPTFPVESRHVMAAVPPAIMKRIEKAARSTSTLAQMVFEHYPMLFHYSPNRYRPALVQLNSEFWFVRQHPGYGKADRALLQFRSHGAIDFDAPNTADGKSGVEPLYAAEEKAAAEAAPSLRRGPRGASMRRPWSVEMLAVLVRNLPRVPTPEGISDGMASKKVSLPREGKPLVRERYRPLNLVQWVNSFPPDDLAFVNKTREVAVVQLITQYVHVFQLMSLKKGDHNLFVEGHVLLSGGAGSAWKADAVASPASSASAVPSIESGDEASPAREAVEEEEGITGWWSVDVASTPEETGTAKSRAGPLKTGNTTSTADDRERAFKQAVAEELIDLDDFAEERGGGATPLDSEGDFSATVEDAHQLRGAALGGEGDGEVFQDGGNEVDTYRDESIPTLQRVSDSQAQREPPKGPCMDEVTTFGLPLEELYVRRLPPDVAPRSLSDLDETTSPDPELLVIAASFLASPPSLQSSTTDCFFRRCRQQRWREVRSIDEVWRWLAVERLYSAFTVEQRRHLRDRYRGLVGFLRYHGKVFELSGDLMYVIAHDPRGTMAPIPPMERVFRYANRVVLPDDFDDNPDRCASLVGEAERKMFVRVLGEGAIPSHRRHLLLLDPDNPLMLHEVLYDEIANLLPDHPVPFIDLMTRLPPVMRAALPHTLNFSASKCIDVYVERGKTMVRKKLAARLGATPSPSKPRMSVEEAIAELLQLPVGKDGISLRALVGMYLSVPATSTLEDHFGSVGRAVRMLPQYFEVWEHDAPGRKRMVMVRLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S8X7</accession>
    <name>A0A088S8X7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_210050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698793.1">
        <property type="nucleotide sequence ID" value="XM_010700491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S8X7"/>
    <dbReference type="GeneID" id="22574827"/>
    <dbReference type="KEGG" id="lpan:LPMP_210050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210005200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_210050"/>
    <dbReference type="eggNOG" id="ENOG502SMQ5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273225at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38148">
        <property type="entry name" value="BAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38148:SF3">
        <property type="entry name" value="BAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="120"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="26301" checksum="7C359350CBEBF259" modified="2014-11-26" version="1">MKKFMLDTRAALGVAPKTIDYDYDEMSVNVKTISHTLSKYLSEIEHMKSACHNLVMAMEGMSKVFDTMTAGNGIPESMKSLAAHYTELARTAQTELLVDYKKVLDDDESITEIRRLVTTCKALETRRNKVRSEYDTYRDAVSKKETVYRRRGKSLSESKVYEGEVARRDSLKAEYEKADKEFKVKYMELSAIKASSYKGAMAVYLESFSQLLTSVEKGMDATKRKIDVVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SAU7</accession>
    <name>A0A088SAU7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">High-temperature-induced dauer-formation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_241330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699473.1">
        <property type="nucleotide sequence ID" value="XM_010701171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SAU7"/>
    <dbReference type="GeneID" id="22575542"/>
    <dbReference type="KEGG" id="lpan:LPMP_241330"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240021500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_241330"/>
    <dbReference type="eggNOG" id="KOG2226">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="432953at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000138">
        <property type="term" value="C:Golgi trans cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026705">
        <property type="entry name" value="Hid-1/Ecm30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575:SF12">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09742">
        <property type="entry name" value="Dymeclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="894" mass="97545" checksum="1A5624CBD96E2663" modified="2014-11-26" version="1">MGLSSSTLEMAKLGRVLLSADAASPESLTQILTTTMTEEETAQVFPVEQLRQLRHLYTRNFAALLYRCIGAISAVAVKRDEVNTSTSSPSALLTTEVMTQYHSALRILRCVLPIALESGTTPLNEAVDVRPNGHNPAAPPDVTRSRTAATAHFQQLFFVEGKTCDDANPEETFPLLPQQDVHLSPMQPYAKPLPLGSFMMWSLVECCFVRGLTLPELPVLPTEARISITHAEVDTGLMWCPGLASEDPIQAFTMRTSTPNFTWAMPRLPRLRKALLEVLFVALSSPVYHEAGFRDTIFLDPLLSTSTVPLMPTLSISMLNAILQFVPYGYLPYTSHLGVEEKELVVASARLLNTTLCYIGVPLDSVPLSERQRSAADDAVPSLDQQVSKASNAHASEQVNSTAADGSEMGTVDHPDGGHPSCTSEASSPPTSGHDGARCDAFVSNTSHSRSGGSGPSTPPVSHVGPPRFVHSVRKALRDITLTEAKALVQRMQVILGVNVYSRQTYLPISQDWFTSLDDFMMLFWKILDLSPACLAQFGTSAYALDYVIPILDYALAVRRSPHYTYQFQLMLFVLTRLSEVRGFVLQCNQVCRATLPFRFPKMSPTRTYNGLIVLALCLVMEMKDLQALVPLFPSCTVVLMNMAPFITSLGREPSIKLVSVFAQVTYRCLRSTLPNSSGSSPTGDAAGRLPFSAGMSNNLVHQCQMVNLCEAIASLLQYQANGSLYLIASLVDHRAVVREAKDAYVVQRTKELTMKVPLPFLINTLDAAVAVALPVLESTVALRNVTKYYVDTAPESTVNNATAAVGVTRTFTHQMGMGEPGAGLAASDEAVDRLRSVTLVGVLPTPHSIVVRKFQSTESVEQWTATTFWTSAFMHSYPGLLGDRDSVKLVQFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SEN2</accession>
    <name>A0A088SEN2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinetoplastid-specific minicircle binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_292850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700889.1">
        <property type="nucleotide sequence ID" value="XM_010702587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SEN2"/>
    <dbReference type="GeneID" id="22577048"/>
    <dbReference type="KEGG" id="lpan:LPMP_292850"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_030014600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_292850"/>
    <dbReference type="eggNOG" id="ENOG502S6R2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271829at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045399">
        <property type="entry name" value="Tc-38"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20054">
        <property type="entry name" value="Tc-38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trypanosoma Tc-38 (p38) protein" evidence="1">
        <location>
            <begin position="235"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="310" mass="34172" checksum="A363193911934353" modified="2014-11-26" version="1">MPNVPASLLNDVLGRPSPWWLSRLSSEARGALSGVDLLATTAQKIQLGRQIYGDGRSATESFCLRDAHGGFDMQTAEAQVILTHGRRLRQFSLNRGDVPLHVDLSDFLSCSGSSVTQVAEEAESLAERTRRNSYTSPFWFTKEQLEGHFWNSCTQHTTRCAPKSRKRVCEVYENPNMFVELGCGAGKTAPYANLDEFRSQSNAELSLFSCISFLRIFSPINVKTQRAFDACVEWRLRVECQQSGCWCSVWGSAEDYASCGFSILDGAIGVDIFDALGNPLFLVNALCTTAPLAVYASCYPSDSIINSDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SFI2</accession>
    <name>A0A088SFI2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein mkt1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_303400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPG/RAD2 endonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701362.1">
        <property type="nucleotide sequence ID" value="XM_010703060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SFI2"/>
    <dbReference type="GeneID" id="22577393"/>
    <dbReference type="KEGG" id="lpan:LPMP_303400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300038900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_303400"/>
    <dbReference type="eggNOG" id="ENOG502QVHA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="17262at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022039">
        <property type="entry name" value="MKT1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022040">
        <property type="entry name" value="MKT1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12246">
        <property type="entry name" value="MKT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12247">
        <property type="entry name" value="MKT1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Post-transcriptional regulator MKT1 N-terminal" evidence="4">
        <location>
            <begin position="336"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Post-transcriptional regulator MKT1 C-terminal" evidence="3">
        <location>
            <begin position="496"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO00562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="799" mass="90711" checksum="479714BBA6EC3C49" modified="2014-11-26" version="1">MYPHSKQSVASTIQSFVTENKVEEKGLKLSELRCLPYSNQVSIVFDGNRVLDDVVQDVHATGPLTIFTASTPWSAYTVISEYTEMVRKLGEYFRACDVDFKPMFVFNGCGFHPMEDQDTTSPAPPIEVAAYSAYNKNKTVRSVPPEAQRKFASRFVIEEDVEGLIVRKLCEVAEETMRAPYLAWSQISAFFAPSNTMTSEAYGSLELLAFPGVDRVITNIDTDAGTFDCVSKASLMAALRRRYDAEFSEDDFSAIALYETKNRLFRVKNRRETFDDLCRLPRDPTRVDAFMKQHRVSDEQKLLLRRNIGALDAPVFTVDAQLVPLSSLHNRPRRCEIRPIFGSPMPIVFFYLFMSGPLLPLPFAIHSQEVLADDWPLIDTSAYRRAAESILPLRVQVVFQLFPIAPKTSDFYWIRQYVVFKKQQQSPESQSRVCKLSNPPTIDLAYWSFIEEELLQSTREADNVYFTDIVSFCGCAVAEPVIYKSVQATLAAVYLRSLDFLGYFTHATDGAESSGPSVYCKALERFDCPTLSEYGVLLIELMRTGTLNDDPLVVVLNRVDDTIPMGVRFASRLVSIIPANLCGPWSGPFDPEMAAFGVITRLFGRTLRVLHEVVAMLLFANRATTVPWDQFNSVVQRLPFHFPAEFSAGFLMTYVLCNPQCTLEELCITFPEMYALDTDLQTLFWFFTMGFEAIRVINYEEPLSYDMVQVVNAARQLVGQACERLYPDVFVAHFPTTDILFVAQNQGMEMGPIDPQMDVPMPMNNMHNQMPNNMNMNLNMNMHPGMNSNMMQYQPPRMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SIV6</accession>
    <name>A0A088SIV6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Iron-sulfur assembly protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_341210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702547.1">
        <property type="nucleotide sequence ID" value="XM_010704245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SIV6"/>
    <dbReference type="GeneID" id="22578626"/>
    <dbReference type="KEGG" id="lpan:LPMP_341210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340018100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_341210"/>
    <dbReference type="eggNOG" id="KOG1119">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1938621at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.300.12:FF:000013">
        <property type="entry name" value="Iron-sulfur assembly protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011:SF1">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="174"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="23417" checksum="EA411E3CA78508DE" modified="2014-11-26" version="1">MLRLSLRRWCAAASSGSSASVSHGPTSTTTLPDFYGKSFSISPRVWAQITRKNSEEGFTNDARYLRLAIDSGGCHGYLYKFSFETKEAFNHEEDVAISEADAVSPSDEAFTGAQPSPRVVVDTLSASKLENARLDYHSELKGSAFVVVGNELVDESCACAMSFSIKKKARPSVASSSDAQSASSGDGGNHRGTDSAAPLAGSFSAMNARPISRRSTMHTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SLL0</accession>
    <name>A0A088SLL0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Macrocin-O-methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_355560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703487.1">
        <property type="nucleotide sequence ID" value="XM_010705185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SLL0"/>
    <dbReference type="GeneID" id="22579584"/>
    <dbReference type="KEGG" id="lpan:LPMP_355560"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350064300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_355560"/>
    <dbReference type="eggNOG" id="ENOG502RXQY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="198480at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008884">
        <property type="entry name" value="TylF_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40036">
        <property type="entry name" value="MACROCIN O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40036:SF1">
        <property type="entry name" value="MACROCIN O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05711">
        <property type="entry name" value="TylF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="385" mass="42142" checksum="D832BAF6BE44279C" modified="2014-11-26" version="1">MWRTVPLYCTAAAVTVEECLHDIHRGRVAAALPRLNKLKATLCTVQGVDFARALCFLFDKKSNLLAARQSLLEELRLHPQHHEAQALLHQVNDTARPLLAPPAEVRKQYPLFSLLFDALLDSTMLTWPRLLHLYQAVDRLARLDMKDSRNGDPGHVVECGTAGGGSAVLMAVVLAEAENSCGILTSPLRRVFALDSFTGMPSPTAKDCLASIPVSASSSSQLKPPRSPDEATASWGTGTCRSPATHVQQLARHFAVEDRLVVIEGLFADSIPARLLSRSDVQRDGVALLHVDADWHASTRAALELIVPVMRRRTAGDRGMGGSPYPCRIVQVDDYHYWQGCREAVDEYVAKWGAGSPHIGDIDGNAVWFAVSRDGDDVTHNTTYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4J8</accession>
    <name>A0AC62A4J8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Heat shock protein 83</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">HSP83</name>
        <name evidence="1" type="ORF">LPMP_3320020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="XUY36710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="705" mass="80907" checksum="AF8312B058703C87" modified="2026-01-28" version="1">MTETFAFQAEINQLMSLIINTFYSNKEIFLRELISNASDACDKIRYQSLTDPSVLGEETHLRVRVVPDKANKTLTVEDNGIGMTKADLVNNLGTIARSGTKAFMEALEAGGDMSMIGQFGVGFYSAYLVADRVTVVSKNNSDEAYVWESSAGGTFTITSVQESDMKRGTRITLHLKEDQQEYLEERRVKDLIKKHSEFIGYDIELMVEKTAEKEVTDEDEEEDESKKKSCGDEGEPKVEEVTEGGEDKKKKTKKVKEVTKTYEVQNKHKPLWTRDPKDVTKEEYAAFYKAISNDWEDPAATKHFSVEGQLEFRAIMFVPKRAPFDMFEPNKKRNNIKLYVRRVFIMDNCEDLCPDWLGFVKGVVDSEDLPLNISRENLQQNKILKVIRKNIVKKCLELFEEMAENKEDYKQFYEQFGKNIKLGIHEDTANRKKLMELLRFYSTESGEEMTTLKDYVTRMKPEQKSIYYITGDSKKKLESSPFIEKARRCGLEVLFMTEPIDEYVMQQVKDFEDKKFACLTKEGVHFEESEEEKKQREEKKAACEKLCKTMKEVLGDKVEKVTVSERLSTSPCILVTSEFGWSAHMEQIMRNQALRDSSMAQYMMSKKTMEVNPDHPIIKELRRRVEADENDKAVKDLVFLLFDTSLLTSGFQLDDPTGYAERINRMIKLGLSLDEEEEEEVAEAAPAEAAPAEVTAGTSSMEQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4V3</accession>
    <name>A0AC62A4V3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Fructose-1,6-bisphosphate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3520070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="XUY36839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="372" mass="40863" checksum="7530C256E97E3350" modified="2026-01-28" version="1">MSSRVNVLQSQLPAYNRIHSAYEKELIATVKKLTSPGKGLLAADESIGSCSKRFDPIGLSNTEEHRRQYRALMLEAEGLEQYISGVILHDETVGQKASNGLSFPEYLTARGVVPGIKTDMGLCPLLEGAEGEQMTEGLDGYAKRASAYYKKGCRFCKWRNVYKIQNGTVSESAVRFNAETLARYAILSQMNGLVPIVEPEVMIDGKHDIDTCQRVSEHVWREVVAALQRHGVVWEGCLLKPNMVVPGAESGMTATPEQVAHYTVMTLARTMPAMLPGVMFLSGGLSEVQASEYLNAINKCSLPRPFFLSFSYARALQSSALKAWGGKESGVAAGRRAFLHRARMNSMAQLGKYRRADDDASSSSLYVKGNTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4W9</accession>
    <name>A0AC62A4W9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">N-acetyltransferase subunit Nat1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3520220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="XUY36854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="711" mass="81341" checksum="180980208CC9F6D6" modified="2026-01-28" version="1">MSLAPSTLPADQQRLFDRMNREYSNREYSKALRTSESILSIVPDHVDTFAGRGLVLYNMDRQEEGYESIKQAILLNPKSMVAWHALGMCQRLDKKFGEALKAFKRALTFDPTNTEVLRDLASVCIQLRDWPLFLEAREKMVMAKASVRANWVALSCGHRILGHSRIAAAVMDTMASIMDTGDTPVEVSEAQLYRVELELESGAPQRALELLKKHDIDIIDVETKLLLRAKAHAQLGQRSEAEKRYMEVIAMGVSEADSIAALAHLQKIPLDRYLRPAVGYTEKYMEIIDRVLKAYPKCDYAKRHALDCGPIGEFSERLAVFVTPYIQRMIPSLFSVLKSLYVDAERAAKMGDFFAALEQELEAKDFSRFGGEASPCYILWVRTFLASHYRRTGDYALAHAYIEKAIAHTPTLELLYLEKAKILAREGKTAEAAEQADMARRLDLQDKYLNSKAAKYYFRDNQVEKGEATMQLFYKPSVVAGDTYLTALESQCYWYEREVGEAFYRKGDYISALQNLLMFERHHEQNHCELSDFHNYVFRRNTMRPWFDVLDCDDNMGRNKFFLKFCPAIVRTYMRIHENGEEAVRAAHVPRPELKFDEVAAGEVKRVKQLHADYYMSDVDLSEPLVKASRYMGHLLDHRNAEASTHTLAIELYTAADKPLLVARALLALHRQQYNKARDLVMAFKTGMYTTTTMDPRVRAIVDEILTIVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A573</accession>
    <name>A0AC62A573_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_351270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="XUY36836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="773" mass="83437" checksum="595E7FE28BF8F9AF" modified="2026-01-28" version="1">MHCPSSTATLTPAVARSSNLQHYRALLQVLAYASQREQTAEQVIRDAIVGGVVVPFIVTHNTNPAVVAMSTGDVACSTPLDASISGDSLSREEVSLTALLLPSSKFIGTTASLLADGFFCFAPLSSTVENSRTTPYQHRSECQVRDLFTFIMLLFPECFVAEIPPRTLLAMRDAEWSASQMQSSNHAESEVQHPSPVLRRSTPTSPLPSILPRGQCTPSTQRVHTSVSDGRGIVVDAESLPHSVTDVSLGGIRTAPLEGLPQLLSPVKLALNDTGASDGEGLEGTTANASVMTNMMALPVVNPVLLTVDVLDVLLESRRSLAVVLLSLMNDALREVQYRQIEQSHAASPRTKVTTAARHPSCEAGVLQFSAEVLLTAKMLLMSVISASAMWRQRVSKAMEIRKAALPGAAPPPPPLLSPFSVLSELLGEKTEGTSPFLTLPVEQWIWGKEKDALEQWNDRLLDRLLMATDAAGVRLDAYLNSAKSTAVSSGRSVSYFPTLLLHRPSDGQPAVELSLASVSRLSDTVRLPSLPIQEGEVHLLLCPSVLENKTGMLRVRGSELLLDTTASPTADFFQACASSACSEAQLQPSGDAVPWLFRRRLTDLSSTEQGIVVAALSDPATISVVLEKNAAMLVRLTLWCRDRWPPLSDASAVRPSTANLSNVITNENGGPKAVYSIGDQVEQHILFERPFSAAVGRYVRELVTLRGLSKDVLEAWMRHVCRGPVATPGAAVDSTAPPPHRAMFAALVKFAVLHNRWRLNPEVEALEKEYVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A590</accession>
    <name>A0AC62A590_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Heat shock protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3520210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="XUY36853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="341" mass="36536" checksum="74C16E516D4F39A8" modified="2026-01-28" version="1">MCCRAVLRTRASFVSGAASTHGCVPLVAVRRWCVTTRQRGSAPSGAPSTDGEAVVRAAKWNSSNFEERLGFSAGETITEERLKRHYYLLAKHYHPDTAAGSAGSSGAAHSSEASAGSAGAFQNIKEAYDVINGTLRRGGRWGGNTSGGSSAAEFARGFEYSDGARRRAQMRLLGDAVLLFMFTTVAFIIIVSGHNKSRMQSRYLWHLVGIFFIIQLFPRLLAAAILFAVHSLYLLERATLQEQAAISLIVERTERACSVKLDGLSAEAQPHVVVQVTTTAESNAAAVEAVSSTLTFDKGITAFTLPVPVDSSSVYYIKAVDEARKIVLVDRALSAGMQAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5B9</accession>
    <name>A0AC62A5B9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha tubulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1320090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="XUY36980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="451" mass="49683" checksum="3D47FCCC1FBC5BF5" modified="2026-01-28" version="1">MREAICIHIGQAGCQVGNACWELFCLEHGIQPDGSMPSDKCIGVEDDAFNTFFSETGAGKHVPRSLFLDLEPTVVDEVRTGTYRQLFNPEQLVSGKEDAANNYARGHYTIGKEIVDLALDRIRKLADNCTGLQGFMVFHAVGGGTGSGLGALLLERLSVDYGKKSKLGYTVYPSPQVSTAVVEPYNCVLSTHSLLEHTDVATMLDNEAIYDLTRRSLDIERPSYTNVNRLIGQVVSSLTASLRFDGALNVDLTEFQTNLVPYPRIHFVLTSYAPVVSAEKAYHEQLSVADITNSVFEPAGMLTKCDPRHGKYMSCCLMYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKCGINYQPPTVVPGGDLAKVQRAVCMIANSTAIAEVFARIDHKFDLMYSKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGAESADDAGEEDVEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5I6</accession>
    <name>A0AC62A5I6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histone H3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1620420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="XUY37053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="66" mass="7238" checksum="D87F239EB5F19D1A" modified="2026-01-28" version="1">MPCARCRACRRRGGPALPEQRDPGDPGGVRCVADGCHEPGQHPREACVTVRPKDVQLAVRLRGERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5Q5</accession>
    <name>A0AC62A5Q5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histone H3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1620050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="XUY37016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="66" mass="7238" checksum="D87F239EB5F19D1A" modified="2026-01-28" version="1">MPCARCRACRRRGGPALPEQRDPGDPGGVRCVADGCHEPGQHPREACVTVRPKDVQLAVRLRGERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5U6</accession>
    <name>A0AC62A5U6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1320250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="XUY36996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="488" mass="52416" checksum="9F31B1E73DE40EA3" modified="2026-01-28" version="1">MSGTCAASDKATLLEQAHQWYRFVAELILGETAAADVGGYRNTHGTRWMGRRGTAAETVGEEEQRLRPRQEHSPAEHLIGQLSQLCPLLRPTAREDDLCGDACALTIRDSALRSFPLNNARAGVHETPPSWQSHTVSSLQNWWDSAADALDALFDAVDMYLDSTSVPPTVGPPALSLPALALGGQSLSQIEAALTGESCIMAGLLLHRDVRPRSGPCYATVVSPVLVVLDLDGTLLRSPLNSISIRAVQVATTAEVRALFVDADFLGSFCESVTRQGHELAICSLTEGTADQWSTSLSVAEAVLCLLSRILPPTRSYLTSTDDVVCLPRSVAGPGKLYHLQELQQRRNARDEGQRLLRSQAHPQLQRQQPTDDAGVEVANDASNSMRLGVFSPPMQTSSSHHDGVVGGLRNPSTLLLPRWLSTDVVLIDDDRENCHIAVTQGYHAASCAETGMSASWYAANPELQVLLGIPASEAAPRSGAHSGRTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A617</accession>
    <name>A0AC62A617_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histone H3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1620100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="XUY37021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="66" mass="7238" checksum="D87F239EB5F19D1A" modified="2026-01-28" version="1">MPCARCRACRRRGGPALPEQRDPGDPGGVRCVADGCHEPGQHPREACVTVRPKDVQLAVRLRGERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A632</accession>
    <name>A0AC62A632_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATG8/AUT7/APG8/PAZ2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ATG8B.2</name>
        <name evidence="1" type="ORF">LPMP_1920140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="XUY37135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="127" mass="12834" checksum="EF18415DD8E68F1D" modified="2026-01-28" version="1">MSAYQSSNTAEARRAECARLQAKYPGHVAMVVEAAKSSKAHLLALPRDATVAELEAAVRQALGISAAKVTLAVEGCTPAATAAVGDVADACKHADGFLYVSVRGEQPMGALLAGFAGPCFASDSGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6G6</accession>
    <name>A0AC62A6G6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histone H4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0220010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009371">
        <property type="protein sequence ID" value="XUY37388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="100" mass="11450" checksum="5AD0E998FA02E601" modified="2026-01-28" version="1">MAKGKRSADAKGSQKRQKKVLRDNIRGITRGCIRRMARRGGVKRISGDLYEEMRRVLKVYVEDIVRCSTAYTEYARKKTVTASDVVNALRKRGHILYGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6H7</accession>
    <name>A0AC62A6H7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amastin-like surface protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2020900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="194" mass="22191" checksum="6A5C0B5FCE518DDD" modified="2026-01-28" version="1">MEFNPFIIVYAAIQFIAFLLVVVGTALDMFRLQSRENFEDRPCITLWGLKPYCNSIVYSLSSDERFSLCPVRRKRFHMAQILAVVSVGVYGTAFALGVIMLYCCLHLRWVCLLLNIVGFVILPIPLALMVLSYKTDENSLCPKLRDDYDFGVGFYIFATAVGMDFIDIVFLLIPWQYDYLDVTCNSKEGNSQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RGM9</accession>
    <name>A0A088RGM9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutaredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_010110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009370">
        <property type="protein sequence ID" value="AIN95112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696654.1">
        <property type="nucleotide sequence ID" value="XM_010698352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RGM9"/>
    <dbReference type="GeneID" id="22571740"/>
    <dbReference type="KEGG" id="lpan:LPMP_010110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000031800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_010110"/>
    <dbReference type="eggNOG" id="KOG0911">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="415696at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03028">
        <property type="entry name" value="GRX_PICOT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000407">
        <property type="entry name" value="Putative glutaredoxin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033658">
        <property type="entry name" value="GRX_PICOT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293:SF70">
        <property type="entry name" value="GLUTAREDOXIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="4">
        <location>
            <begin position="100"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN95112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="195" mass="21289" checksum="3060559EFF4599ED" modified="2014-11-26" version="1">MLSFSYRPLMRGVLATAGASLMALPNRALTATTRSLYSSNLVRLAPVVPPKDAPPTMGGDPDLEETHPDFQPRIVGGDLAEDEIAMIKKDIVDTIRDEEIVVFIKGVPEAPMCAFSKRMIDVMEALGVEYTSFDVLAHPVVRSYVKEVSEWPTIPQLFIKGEFVGGVDIILKMAESGDLQMLLDQKGVKHCGAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHQ2</accession>
    <name>A0A088RHQ2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phospholipid/glycerol acyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_041000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="AIN95423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703745.1">
        <property type="nucleotide sequence ID" value="XM_010705443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHQ2"/>
    <dbReference type="GeneID" id="22572059"/>
    <dbReference type="KEGG" id="lpan:LPMP_041000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040017200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_041000"/>
    <dbReference type="eggNOG" id="ENOG502S71D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="431951at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434:SF48">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="4">
        <location>
            <begin position="131"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN95423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="355" mass="39779" checksum="E7FD5FCA7B19913B" modified="2014-11-26" version="1">MGAAVARVLHDVAACLPRLPPARHGTLLAVALGAGYVLLRQRLVPKWATQKWFLLSTTALMIPSCALAYLLDPLRYLGVPRLCVQNVCVFILSHAFKAIWWLNPQIRMHVKFDANGDEKPACWDDISRTGVAFMLNHTSFWDPFQMIGITPTAHLMQTRTLMKSSLRKIPIFGGIFDRVGHFPVYFKSDSACSFEVDKERQAQVQQAIDAHLRLGGSLAMFPEGAINKHPQVLLTFRYGTFATIIKHRMEVYYMVSVGSEKTWPLGMLYGGLPADIYIRIGAYPIDYDRDSSKSLAVGLQKRMQEVRDEIEAEVAAAEEAERRRRGLVSEAKETIIRSVKPLRAAREAHAATLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHT0</accession>
    <name>A0A088RHT0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_050910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="AIN95532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703854.1">
        <property type="nucleotide sequence ID" value="XM_010705552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHT0"/>
    <dbReference type="GeneID" id="22572169"/>
    <dbReference type="KEGG" id="lpan:LPMP_050910"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_050014000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_050910"/>
    <dbReference type="eggNOG" id="KOG0428">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000109">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 J2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="6"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="456" mass="49215" checksum="E4C742F92FF6551E" modified="2014-11-26" version="1">MSYASTAIKRLSNEYRHLQKPENRVREFYAAPLEANIFEWHFTLRGPGGDDNSLPYKDGIYHGALIFSRSYPLEPPDILFFTRSGRFAVHEKICSTISSYHKELWQPTYDIALTMTALHHFMAQEDEFGVGAFPKGMVAVDIKEAWAKETWSFKCSTCGATTRDVWETEMKMYPEISPEKAAQVPKLPPTATTKAASATANSENTKVQQAAPESTPSSSSTLLPSLATADATETTAQAEGTRSSPLMALSAPTPPPPDATATPPPDAFDALHGTGTSASRISPRRDPHATAPAAATVDANALQSTTPPVHDPSHILSPAAHQHEERDASAATKEAISEGDDALGYFTDVSPARVVRVPMMTASSPPPPPEPDHPYDTRLESLVHEDLQAEADATSPVTAGVANDAVAPPQLAQRVVLGVDAMEVSIPLRTLDRAIVASLLLVVLILLRRGLCWLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHT4</accession>
    <name>A0A088RHT4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">cAMP-specific phosphodiesterase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_040030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="AIN95330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703652.1">
        <property type="nucleotide sequence ID" value="XM_010705350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHT4"/>
    <dbReference type="GeneID" id="22571962"/>
    <dbReference type="KEGG" id="lpan:LPMP_040030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040006000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_040030"/>
    <dbReference type="eggNOG" id="KOG3689">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="189220at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="4">
        <location>
            <begin position="116"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="676"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="699"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN95330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="721" mass="78707" checksum="E2FA907C5A3DF449" modified="2014-11-26" version="1">MHPLDVLAALKDDSSLSPQLRDKIGGALARLRETCRTAGQPSTKETPPRSCAHNYFEEMISGHAPFRLSCHRSGLIHTRAKDFDIASSRLPGSIIMSSCNTLMQRTTPALQSPKGVFAELNAIAFQTLRYIDEVEQIEFDVTNVREHDGSIMGDKERLFLSVCCSVFANFYFFTSLCINAEKFLRFLRKIFTCYPLDNSYHNATHAADALQMMSLFFREPTVNFLFSDEEIAICFLAALTVDVAHPGASDALLVALDHPLASVFGDVAIAEHASLLVLTSALVREDNFFFSTTDESVSADSAHLVKEALYDVVLNAALRNRPSLMSALHNIDTSGHITDADAPKLMAALLVMASNSFAFRSQAQCCRMGTWLLSEIHREECEMERHGIRMTLPHVSGADLTTVLSDYINVVVKPMTAATLALVPTDLQDRLEWNADLVDAATGAGGHPCSVILETSLAPWMTSSLHVMEILKKVATHAKSVDRKASKCAILNASPSRFQGAAAGMMQADSLSSSSSMSGSINATKQEEATTHRSPSLFTSQLYVAGGSPAAHPSRSEHYFSFLRLYDKCERAGELAKDFLGQLIFLALQLDPRYIASYAQKKYGDDGCAAECTEMGLLIYKTEEAPSSAEVIASRPPGGSFSNRVADEIDHTDGFILLLMDMYCSREAALAEMESAASVSDKAKTTPPAEPITLEGAPQYQQNSPIRMPVNTESKNTVSWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RI21</accession>
    <name>A0A088RI21_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome c oxidase assembly factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_041080</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the SCO1/2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="AIN95430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703752.1">
        <property type="nucleotide sequence ID" value="XM_010705450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RI21"/>
    <dbReference type="GeneID" id="22572067"/>
    <dbReference type="KEGG" id="lpan:LPMP_041080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040018100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_041080"/>
    <dbReference type="eggNOG" id="KOG2792">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270009at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02968">
        <property type="entry name" value="SCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000013">
        <property type="entry name" value="Blast:Protein SCO1 homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003782">
        <property type="entry name" value="SCO1/SenC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017276">
        <property type="entry name" value="Synth_of_cyt-c-oxidase_Sco1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151:SF5">
        <property type="entry name" value="AT19154P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151">
        <property type="entry name" value="ELECTRON TRANSPORT PROTIN SCO1/SENC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037736">
        <property type="entry name" value="SCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="10">
        <location>
            <begin position="159"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR037736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037736-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR603782-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN95430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="298" mass="33495" checksum="6D4AC69347A0ED65" modified="2014-11-26" version="1">MTASYRPGALLHLRSSFSFMRRGFSTGATVAAKAAALRDATTTTSLTCSHRAFRKQGAANPNNTDAAEAAELEKDRQALKKYGALGGFALLCIATLWYGSRQAKQRYFGAEGSARVSVETRGRPALGGPFVLVNTKGYPMSQAEFLGSWAFFYFGFTHCPEICPVELNRMSHVVDAVHAARPQERIAPLFVSCDPRRDSLEAIDEYLSVFHPDFIGLVGTPKQVNDACRSYRIYYSIPTEEDTQQEDYLIDHSIAIFLFDPQGRFVDFFGNRYDEREITEKVLHYMSEYAKDPTWTNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RI44</accession>
    <name>A0A088RI44_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_050190</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="AIN95460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703782.1">
        <property type="nucleotide sequence ID" value="XM_010705480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RI44"/>
    <dbReference type="GeneID" id="22572097"/>
    <dbReference type="KEGG" id="lpan:LPMP_050190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_050006900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_050190"/>
    <dbReference type="eggNOG" id="KOG1049">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1917198at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051252">
        <property type="term" value="P:regulation of RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000003">
        <property type="entry name" value="Zinc finger CCCH domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007854">
        <property type="entry name" value="Fip1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045877">
        <property type="entry name" value="ZFP36-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="CCCH ZINC FINGER/TIS11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547:SF18">
        <property type="entry name" value="PROTEIN TIS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05182">
        <property type="entry name" value="Fip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="308"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN95460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="350" mass="36765" checksum="3FA55D8D4F96229F" modified="2014-11-26" version="1">MESGGGDFFVINDVEEDQEAGVADARPAEQAQETEAETTEDVKGLVPLCAQHVQGPQLSSATFGYDIALMAKRPWAEPGAKLNDYFNYGFNEQSWRVYCAMQENGEESLLAKATAMLEKLQLAGAPPAAAAAMGAGGHVAREEPPMMMAGGMMEGYGDGGPYGGGHGLYGGQEGPGRGGGYGRPYQPREFNPHGGGSFERPHNANYKTRLCKGFAEGHCNRGDQCNFAHGVDELRQCGGGEPIQPQLPPGGLVGGGSAPPPMAQGYGDHRPGFNNYYTPPPPQVMAGGAPPQAPERVNYLMPPFQGGGGMPPVMGPAMSMQDSGDGAGSGFRQPPKRPRQEGGGVYEPQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIH9</accession>
    <name>A0A088RIH9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_060410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703922.1">
        <property type="nucleotide sequence ID" value="XM_010705620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIH9"/>
    <dbReference type="GeneID" id="22572247"/>
    <dbReference type="KEGG" id="lpan:LPMP_060410"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060009800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_060410"/>
    <dbReference type="eggNOG" id="ENOG502SFFR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267036at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="566" mass="59267" checksum="EDBC848E7D80EF9F" modified="2014-11-26" version="1">MIPTLNMNKIRSHTTVAVPAAGGSGGTELNSSGSGSSGPRLMTGRQISPRPPYLGSPLETSSLPSAHFQRRAADVATVLDMNPLQCHSVGDLQRKLIETAEWVVKLRHWYVHQLQERDAWYECRLRGLEDAFHAALTPATAARTAYATARADAAQTVTGCISAEHAAPSTVATRVAAGGASVSSAVAATVSVFAEKEVDSGTVLQNRRRAHKNSPAARAAAGPRNDKNPGMINFNQSSAVDTDLAVAGAANNADGGSRTPLRVGPPKRSEVVPIVHGRRTASVGAPSRQLLALEDRESPRISAVGIAVDRDESRPTLAERSLAATVPIILDNGDDTSRDPHNPSPLLHLRGRGAGGISLTPFATNTQVIGTPMTGTVGLRRDVQFATTPLSGRPSSANARLSTASAAAESSGRLSARAGGIGGRRDDAARSERNRYYLSLSRSISGSTKIGLSHFAQYLNASTSRDSAVTGAGTGSSATDGVASSPHEKAPRISPYLYIIRSGDSHSRNLKRRSASTGGSRRACPVYITRKAKASSAGLGVSGQHCKETGSSDVSEQSSLRRFVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIM8</accession>
    <name>A0A088RIM8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_070670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009376">
        <property type="protein sequence ID" value="AIN95753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704075.1">
        <property type="nucleotide sequence ID" value="XM_010705773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIM8"/>
    <dbReference type="GeneID" id="22572402"/>
    <dbReference type="KEGG" id="lpan:LPMP_070670"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_070011900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_070670"/>
    <dbReference type="eggNOG" id="ENOG502SB3G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273736at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="286"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="519" mass="56897" checksum="BD0A43FE95B13AAB" modified="2014-11-26" version="1">MSSPRTHVIDLGCMPREELIEIAKKQANQIREKNKRISAMETFIESVTGAPAEESLSQSSRGYQSAPMHNSSTETSAFSAGSGTATDATASASQLRQLQRELEEQQVQHSLRVSELEEQLRERQREYDQLQAKVDTWKTKVMTVMMADQERIRGLEAQLAAATAPSLDSGEPVAAQHQQQQHFQAQVSALQQELYSVREALQQAHSQLQEQHCSSVQPTLPSAAATSITESFLTKAPPAVLSPPPSLPSTGLFDNTLSAPPAQMAAADIPPEVLEDAVQAKLALWKERVKGAMLEDKNRIQELEAQVAALETATNAAQTSAEEHATEMSRLQGALETAERERENATVAMNSFRENMEEWKEKAHSFLENGEMQRRALEAEVQRLKEDQLAAAAPVERKETWSQTDVAADVLENSTTVSPVAAAVQDVEVQASVTTDVPFSVPKDMSLVPSPVVLPELHLHSLQALLGECERVAAENKRLHRAVAQLFRFREEVMRGVRAVATPPGAAALGKMLEEAVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIS1</accession>
    <name>A0A088RIS1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LPMP_080790</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="AIN95887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704209.1">
        <property type="nucleotide sequence ID" value="XM_010705907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIS1"/>
    <dbReference type="GeneID" id="22572541"/>
    <dbReference type="KEGG" id="lpan:LPMP_080790"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000024400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_080790"/>
    <dbReference type="eggNOG" id="KOG0589">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="252033at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08215">
        <property type="entry name" value="STKc_Nek"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000097">
        <property type="entry name" value="Probable serine/threonine-protein kinase nek1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000172">
        <property type="entry name" value="serine/threonine-protein kinase Nek1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="29"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="336"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="427"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="529"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="615"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="780"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="958"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="617"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="644"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="978"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="996"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AIN95887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1140" mass="118563" checksum="760D73C59CCAA989" modified="2014-11-26" version="1">MNSVDELNLLLGIGPSRPQLPLTLRKSGYLPVRSLGKGSYGQALLVFHEPKKQYFVVKHINLGCLSSRQRHDAHNEINILQKLHHPNIVRYAEYYEEHLHLYIVMEYADGGDVYSLLSSAQAARKLGAAGRYRGDSVATPGLLSEAQVVSLFVQTTMAVKYMHDRRLLHRDIKSSNVFLTKNHVVKLGDFGISTVLQSTVAMASTMCGTPCYFSPELCQGRPYNSKSDMWALGVLLYELCAGHVPFESTTMKALMRDIVHKQPPHIPAVYSEGLWELIVQLLQKDARRRPDAGQVLMSPVLMKHVPDLIDQLAADTASGGTPSLGGVDSIHVDEAPRAPAAAPPPPPPRKAQQVLPPPDKAGGGGVASPGLPGAAAAASPLSLSPSPLSQAQRQRHPSRSGGGAGASSIEALVARFDAQKQQIVEARKRKSGYQAELQSTDGTGGVPHASGAEGQSRFSPGSAAALRQQELRVNGGGGGGGVAPTRPSVGSARPRATGATPSQAAFMPPPLPTALRDIGAIDQRCPVGLPTTPSPPSRQRGSVAAAQTPKVKNVDAALQAPNARVGEQAIRAQPYPAASQRRHVVGELDESAAPPLVARGAAPAADELNAMLSELSSWRERSVRRQLRQDSHRARRNNTSDKSVVVAKPKPAAAKLDTDIPSPQPPTSPSAFSAPRNQLGRLAAPPNFHRPGVAEGAVAPGPKGNAALHARQPHGAGGGVQASEAHTRDAAPPLSGATAPSLGANTHSSDDDGDRSATLSFVDALGTALDVDAVQAAAAAAQQQRPLPPPPPLTSEEAGSAACLSGRVPFSQQSMKKTFHGTSDRIDSLQSTLMAGTVFRHIPVTAMQAGTMRGACADATATAAADCAGEAEGAADIHFRTSCLCGRAETSHGYLSMIYGSFVCSCSVCVRFTGAAHGVEWLHLPEVAHGLPALLSSSTPSDVPGGCSTTATPSAGVGAAAAAVPRAHSRGTPLSHNRNQEAEAKGKGGDSASCAPLTPTQSPSPSSRCLRTASGARIGDEATEALGQANIRAYSHRSQVAAPLQLEEDLRQPVLHPPGSLLAGGGVATRSRSVLYIIYTCLTCGALVGMQHEGMEGILLPKTTLDTQSLDILSSCAQAVDLDAAEVVAVGGGPPCDGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJ25</accession>
    <name>A0A088RJ25_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_071100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009376">
        <property type="protein sequence ID" value="AIN95795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704117.1">
        <property type="nucleotide sequence ID" value="XM_010705815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJ25"/>
    <dbReference type="GeneID" id="22572445"/>
    <dbReference type="KEGG" id="lpan:LPMP_071100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_070016300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_071100"/>
    <dbReference type="eggNOG" id="ENOG502SN8H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266105at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN95795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="190" mass="20168" checksum="190F2B890A6244FD" modified="2014-11-26" version="1">MRCATRISRSPLNSAACSPGSACFGVSTLRAVGAIHGVQVGSFSLTAGVSAGLQCTLSTSSFFPVDCRDCGACAPPLPAEPAELDVPGVAPPPKMSTGGNVYTLHVVGPTAFIAEAAEVLGDDVLVDVTGKYHVEPYTFWRSGKYECPTVRLTYDRLRSTADSLRILRAPDNTVARQRRLYRAIFMGKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJB5</accession>
    <name>A0A088RJB5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thymidylate kinase-like protein, putative</fullName>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_100030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thymidylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696725.1">
        <property type="nucleotide sequence ID" value="XM_010698423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJB5"/>
    <dbReference type="GeneID" id="22572739"/>
    <dbReference type="KEGG" id="lpan:LPMP_100030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100005500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_100030"/>
    <dbReference type="eggNOG" id="KOG3327">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="425602at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:dTMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006227">
        <property type="term" value="P:dUDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002288">
        <property type="entry name" value="Probable thymidylate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344:SF1">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate kinase-like" evidence="2">
        <location>
            <begin position="143"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="363" mass="40139" checksum="119E3E6B70B66A11" modified="2014-11-26" version="1">MRAVVFSDIASAELIEHIRVIASRSYAEVVYVDVSEGAETDLKTAWHTRYGGALHAPPPARDELDDMKGTFVCYLTEKKTVEDADVVYAVFIAEVLTLILTPSATLTPLMHAAADISVSSRKAAIESLFSVAPSPSSADVIVVEGGDGAGKETQAALLVRQIHASGGEVHALDFPYERGLYGGLVRTVLSGKKGSIDELNPQLFSFLYSLNRFGCARQLHFWLRRGSSVVLDRYYTANFGHQASKLPPEEREAFISDLEFMEVELLGLPRATSVLYLDLPPAAALEAMRRDATRKQLDIHETAGGDYKKRVRQTYMWCCEHLPGWHHIMCFGDDGRRLTREEVHTAITRHLRSVGSRVFGAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJE3</accession>
    <name>A0A088RJE3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_030250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009372">
        <property type="protein sequence ID" value="AIN95259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700967.1">
        <property type="nucleotide sequence ID" value="XM_010702665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJE3"/>
    <dbReference type="GeneID" id="22571891"/>
    <dbReference type="KEGG" id="lpan:LPMP_030250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_030007300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_030250"/>
    <dbReference type="eggNOG" id="ENOG502SF12">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264739at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="19458" checksum="929D9D2BA9BE47CE" modified="2014-11-26" version="1">MDNVLHPAGGINAMPAPAPPPAGFFPQHPPVANAVLGPSPSGHQPPPPEVQRYWHSYRLWASLQPHIQQDQQAVLQLRAQAHIAKVAQQESLRQHLYRTMYWTLFVVCPLLSLLFLWLAIDAAAYGAELELLPFVKYDEALRDFAEAEGHHRHLRHGKGHNGATRKKKTIRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJY3</accession>
    <name>A0A088RJY3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hemagluttinin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_100460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696768.1">
        <property type="nucleotide sequence ID" value="XM_010698466.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22572782"/>
    <dbReference type="KEGG" id="lpan:LPMP_100460"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100010800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_100460"/>
    <dbReference type="eggNOG" id="ENOG502RWGC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="262785at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23202:SF124">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23202">
        <property type="entry name" value="WASP INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6355"/>
            <end position="6380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2343"/>
            <end position="2376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="6449"/>
            <end position="6732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="450"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2344"/>
            <end position="2363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="6449"/>
            <end position="6463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="6464"/>
            <end position="6479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="6513"/>
            <end position="6529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="6535"/>
            <end position="6545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="6561"/>
            <end position="6572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="6579"/>
            <end position="6595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="6596"/>
            <end position="6612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="6732" mass="708977" checksum="635300EB79C7AFC7" modified="2014-11-26" version="1">[encoded data, 6732 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RK29</accession>
    <name>A0A088RK29_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_110730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696921.1">
        <property type="nucleotide sequence ID" value="XM_010698619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RK29"/>
    <dbReference type="GeneID" id="22572938"/>
    <dbReference type="KEGG" id="lpan:LPMP_110730"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_110010900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_110730"/>
    <dbReference type="eggNOG" id="ENOG502S3FW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273372at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037696">
        <property type="entry name" value="CCDC77"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22091">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22091:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="115"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="326"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="487"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="555" mass="62917" checksum="09D183B009D09805" modified="2014-11-26" version="1">MPGCHAPPARLAPHIGGRLYEDASLVSSTSQPASSIPDLTCKRASSLSRVQLQHRREEQLRHALEHTHPSQAEVSAVASTAYVQALMDLIDQHAVTVQQVTGNIDALREQREDRYIEFKQEVQQREVELQRLRNERSDLTLQVQEERERSTRLLHENTVLHAHQAEKREQLEKLVELCRARGRRLSALHKQNSRVTGSTPHQRRSMETNAGALAGASREDAITADVGDEESDPELNRMGISAKGTRAPASSAACSTSPALTSPPASMSIHKAVGATASFQWSSSSSPAALSGLAEDTEVAALLNVPYKVQVPGTPFGPSSHTITANAAATAHLLALNEEVNMLREQLEEQRATYEQERGARTTENDELHRQYLEKEAKYRTTIDQLELLHEESLRDLVQYRHSTEKRLRDVRGQVDWLRAALQEALGLAEKERRRQHNEVYTTEQRMSLQYYPKVQSLHAELEECRRGALAQAQYSTKVIAEKDALVKELRQKLKAEAGQRKRMEERYRLEMKGVHSELDLMRQSLRQMERRVYYRDVRDQASEEAQHGLERYYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKD0</accession>
    <name>A0A088RKD0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Anion-transporting ATPase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_110750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696923.1">
        <property type="nucleotide sequence ID" value="XM_010698621.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22572940"/>
    <dbReference type="KEGG" id="lpan:LPMP_110750"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_110011100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_110750"/>
    <dbReference type="eggNOG" id="ENOG502SG6C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267350at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037">
        <property type="entry name" value="FORMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037:SF24">
        <property type="entry name" value="POLYCOMB PROTEIN PCL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="317"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="372"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="465"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="567"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="663"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="769"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="852"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="900"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1082"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1136"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1324"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="589"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="771"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="900"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="935"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1082"/>
            <end position="1103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1445" mass="151276" checksum="926AE9D7D0309ED0" modified="2014-11-26" version="1">MTSAAPPDTAVAAMRLESLRFVGYEQLDSGDGGFVHLITPQGGRVRLYPSRPSSLVALSPLLPQPPASRHLAYPPSPLLPQPLGCKPTQKVATPTATLADARQVLKDAAMPHASTAAVVPLAPPEGFEVEFSFLSSEESSAELSRATSRGASPPPQPAEAAATETECVDHAPTDTANTGGGEPTVLDDTTGELEGRALEENFIPHTFVHGTELTASATSLAELDDELTKCALILFDGRIPQSPPLLGQAEAPPRWSEAVNYHRAVLLGYDDAGFAYIDGQAFAQRVSPPQGWRLFPLPLLVCVAARLSHFYRDAELADRAGEQSTDPGISGSALRYPVLPRPARTTTAGSSGEFESGWLSRNSSTCATVFPPPYPAPASGEPPVSMSSGTTPPASSLTSLTYLSPPLRWSLPTCGHAPMLDLQELFQVQPSRVYQLAQPPGEAVFLGVALGVPWIRPVVLATATPSSVSSSSPVAERRGAMPHETAPLTSSPGSQPPAGYRWKDMFAWAVPLVGCHDASEIRARHGLIDPTPAATDVLPAAAVADTQGSATPSVPPSAVVGAVLEGSEQAPSPQTNEADDESSRTSAPLSPPPQSPSPPPQSPSPKPLTAAAPFFVKEGTTVFVPGRFGVMLECNTKPALMVAHFGVAHGDRLVPRALSTHPAAAQLSGAPKPGEAPTPPLPSGSLTVMGLHGRNVLVLLADGEGQTAELIHITRGAAEVAEAFRKVAGAPLSPPALPLEPLSVPAFSLESTNITDSAAAVHLVVEDEDSQERPQRLEKERWDGEAASMPRAATWISTEETDAVIVPSSIPSGEVPLSMYEAAETQGAEEVREEVGTATPVVDGAWNGVPPPIKAVMPASRSEAGEGGAHSSSDRIMDIWQAAPTSAASAQHACQWSSATSSSVSATSPESQALPQGQHQRQQQSLSKQIAEAKGNNSGPSTARVDPSSTLTKEVAVQATEVCPTSAEQLVDPAEELTVVSVVTPTTSGAPPLMTVSAANHTTTSPSGEVVVEAKAVSFVVEAASTSTPSEKDVLLHNLEVVPADARLHENLDLQLLEKEHSVRDDEMGLHLKHDGSLLAQALSSNPTPSVRLTPSSSMTQPSKWHPTDDVLEKSLAAEEHFNSDGADVYRLHAAQTSDHEERNQHSSGAHAGDDSASDAAFHLRSLLAPPQQQRWVSEARSSLHSAISANEEVAATTATTQSLELSSTVMPRSHYAEEAVVGGAARQTPPSPLLAHPAMTFASSCSPPPAGTAACQAASRAGAEQVTSYPSLATPPCSAAFGMQHYSTAKSSEAATASIPTPFTNFLKAYGIYVLSTHGALSGGESRQLPNETSPHMGEHAAQTGEPSWGRVELSSILSFYRAQPLARIMEATAIQRRCRAAWKAAITSRPTSAAPQAVNDLQVCKLKASASTTVFEELCVNELVSLLSIVHHPLPERERTVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKD5</accession>
    <name>A0A088RKD5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase family, putative</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_110850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696933.1">
        <property type="nucleotide sequence ID" value="XM_010698631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKD5"/>
    <dbReference type="GeneID" id="22572950"/>
    <dbReference type="KEGG" id="lpan:LPMP_110850"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_110011900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_110850"/>
    <dbReference type="eggNOG" id="KOG1838">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="247542at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034338">
        <property type="term" value="F:short-chain carboxylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF63">
        <property type="entry name" value="ALPHA_BETA HYDROLASE 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="176"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="490" mass="54577" checksum="418FC5A2D19E4FD1" modified="2014-11-26" version="1">MLYTAAFACLHVSVHVLLYALPRWLWIVCVRWPLQVLSVLLGIRFFTHDPKHERRVHILGLTGSSSLSPRVCLRDRFGITEAQLSNLVLHHKTASSSSGDASPAWWRYNGPLYNGHVHTILGALRPLLDLRVPARETVPSYDGNPTCLDWWFPTDGDTAATAASGGAAIMCVRALVVILPGLMGSSREFYVRRMARQLLRSNMVVCVLNARGVADTPLERPQIFSALFTKDLRHIMQTHLTREKVQERLLRRIPPLQTDDINKGAVPIIGVGFSLGGLILTNYVSEQGEAQVPSGFDAVYSITSPHNVSDSAAALRMPLARLLYNSALHKGPHAYYERHKHVLQHLPGVDKKIFMDDASLFVERLRTLQDFDELITGPHFGYPGAEAYYAAASSFLRLHHSRTPQVCIVAANDPICGPPQPTPRWLQLIDRHRGGLVYVEMPVGGHLGFLGCPWSEWTQAPNEMERFVLHSLIHFIESADTQAKAAKKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKL4</accession>
    <name>A0A088RKL4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Palmitoyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_130540</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 8">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family. PFA5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="8"/>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697136.1">
        <property type="nucleotide sequence ID" value="XM_010698834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKL4"/>
    <dbReference type="GeneID" id="22573164"/>
    <dbReference type="KEGG" id="lpan:LPMP_130540"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130009600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_130540"/>
    <dbReference type="eggNOG" id="KOG1314">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="302728at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF23">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="10">
        <location>
            <begin position="289"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="193"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="516"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="589"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="532"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN96483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="611" mass="66558" checksum="FE2EA63B30F5983F" modified="2014-11-26" version="1">MTVSELPATSNPGLLNYMTRALLAGGFIFIVTFLMSVHFYYATAALLDLVALLILFLFLASFCLSISSLVMLTLVGPGELPSRFSAARMESFIREELQRAVAKARSGCGGDKAATTAGPAREGAANGCNKNDGVTEKAMTKERKWSDVDEADSQQLANVATAAAILQRSSHAAEEEVLEQAAAEARLRIYAEDSDSASHHSDGGTAAEECEVQRGGQSNDADSEENAAEDHSELPAYMTEAMQMRRQRKVRRGLEIVLVSQAACKVLEAIDGTDMDRKQEEMSFLIPGANWCRFCNFYQMNDTRHCKVCDRCVYRSKLHCICCGRCIGYANSKYYVLFLFYLCLSLAMADVLDLYCVSWGYTYFFKPSGDANSVFYLVFVYSASFVVVGLGLLIQYLYAAGRGVGFLTDVLRQQRDELQATRIHNNGEQYQPILSERAVHVAEEGSASPMEEASPFSWRTAMETVGEGLPLYLWFWPTPTLPVVKETDDPPGFWDAFKEAIRLRLRSVADEDDVFSDEDELGNGEAADALSPSASVPSTANTAHVASSPPAASPMIPLAARVPYHAKGTDVTAEVFRATAPTVPRAAAPAYVNPSVPPTAKVASVPKHGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKM2</accession>
    <name>A0A088RKM2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="15">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LPMP_131400</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 15">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 15">Membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="15"/>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96567.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697220.1">
        <property type="nucleotide sequence ID" value="XM_010698918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKM2"/>
    <dbReference type="GeneID" id="22573250"/>
    <dbReference type="KEGG" id="lpan:LPMP_131400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130018700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_131400"/>
    <dbReference type="eggNOG" id="KOG0206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000203">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF150">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 14 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AIN96567.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1096" mass="123879" checksum="BE504DBAF5F25FB9" modified="2026-01-28" version="2">MPDQGPWWRKCLPASIFPKVCSWACCSVMEADVDEDAEVIVYMNNPELNAQFNYPSNFICTSKYTLISFLPLCLLFQFKKVSNVYFLINMIISFIPGLSPWSPATSAVPLLVVLIVALVKEGVEDAKRHTADKRANSIAALVVRNGELVSVKSKDIHPGDVMYIANGEEVRADVVMFATSLEEGQAFIDTCSLDGETSLKSRKAVEATWPLCKVETIMNSTAVLHTSLPDPGLLSWTGLLELNGEEHALSLNQFLYRGCVLRNTDWVWGMVIYAGIDTKLFRNLKEKPLKSSNLDRKLNYLIIAILIFQQVMLFIIASMAMWWNNRHRDHPYLFFFIEMHKGGRLWGYRYLTYFVLLSYCVPISLFVTIEVCKVIQAQWMRVDCHMMEYMNNRWRHCLPNTSNLNEQLAMVRFIFTDKTGTLTENVMKFKRGEALGIPIESDRLDETITRLRKEEESKGLGQLQEYFLALALCNTVQPFEDEKADFGIVYEGTSPDEVALVQTAAAAGYRLTYRTTKTITILLRNNTQKVYNILATLEFTPERKIMSIVVEDSGTKKITLYSKGADSFIRSQLSRGPDVQEHMDNIDNTLTEMSLMGLRTLLVCARDITRQQLDPWLVNFTEAGKSLHNRSSTVDKVCLEMEKEMRLVGATAIEDKLQDEVPETLSFFLSAGVIIWMLTGDKRETAVTIAATSTLCDPRNDFIDHIDIGHTSPSDPKAIERVGRDLDVVEQHLALKGTHQERRCTLVIDGPALSIAMEHYFEQFLRVSQQVNSAICCRLTPIQKANVVSMFQRSTGMTTLAIGDGANDVSMIQEGRVGVGIIGLEGSQAALAADYAIPRFKHLRRLCAVHGRYSLFRNASCILVSFYKNITVSVVQFVFAFYSGFSGLTLFDGWVLAFYNVFLTSIPPFFMGIFEKDLPEDLLLERPKLYTPLSRGEYFNLVTLLRWLTESLTTAVILFYVAYPTLVRQDGAHQRYAGNEVGTIVFSGLILVILVRFALQIHYWQWIQALGIGLSAVLFMLLIIIYSLIPSAGGSTNFYFVAFDLMSTAKYWLYLLFYISAQLVVTLGVMAFQKLFFPTLQDVAEQQYAVQHGGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKV2</accession>
    <name>A0A088RKV2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_071040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009376">
        <property type="protein sequence ID" value="AIN95789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704111.1">
        <property type="nucleotide sequence ID" value="XM_010705809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKV2"/>
    <dbReference type="GeneID" id="22572439"/>
    <dbReference type="KEGG" id="lpan:LPMP_071040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_070015700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_071040"/>
    <dbReference type="eggNOG" id="ENOG502RSIU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.340">
        <property type="entry name" value="Nucleoplasmin core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041232">
        <property type="entry name" value="NPL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17800">
        <property type="entry name" value="NPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoplasmin-like" evidence="2">
        <location>
            <begin position="4"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="121" mass="13139" checksum="1FEB740036BBF886" modified="2014-11-26" version="1">MEEFYGMEVFVGKTAKPSISADRVLHVTQVALPPNASHAITLLVKAEGKSFVLATLDPHRALFHMSVDMLFSGKQELAFTCEGAAGAVHVIGYTQLAEEEEEGEDMDDEDYDDMMAGEDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKY2</accession>
    <name>A0A088RKY2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclic nucleotide-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_140050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697241.1">
        <property type="nucleotide sequence ID" value="XM_010698939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKY2"/>
    <dbReference type="GeneID" id="22573272"/>
    <dbReference type="KEGG" id="lpan:LPMP_140050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140005300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_140050"/>
    <dbReference type="eggNOG" id="ENOG502S8EK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272675at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="504" mass="55028" checksum="DFCE2CA3DFD13D7C" modified="2014-11-26" version="1">MVQLAEMPSVHSLTSANPVLQALPLRTLRALRLQLKPLVFLQFDVLCHDVANSDKVFFLSRGRVLMEDSSGCSSTITSKAWTAVGLETFVPCRLPDYYDQKLRAKAVTYCEMWYIPTDALLAMCDVAIQLRCAHAATQLLGSDTSRLALASALRTCPCFAGVSEAAITAVAQALQARVYWAGDTIVASKRSPRTGILVVAGMVFVHSDKKTPPQRLCTGQSRYFCECFVKMALEESVVSQSNSIVLHGSPGIILELMEELKPASDDIKIMLDSAQEYVNGRYGTGASDHSKAQNAAAERVRDFKRRCAEAASTTSPPGSNTDTLALLENELLVSLTLQLQALHLDPTNEAKFGILLEGQLAIGDDDAPSKFRPTEECFSLDDEGKLVICTSPAPIAPAHPLTEVPAAPSVFVFAPKTDVVTASLQQRERTKKKLASTQATAPVVPQSRRTAVHASVPATIEQRRVPSPRLTVLRTTATRPREEANDVDRRREQKHQLLRLKHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLB1</accession>
    <name>A0A088RLB1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_090630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN95979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704301.1">
        <property type="nucleotide sequence ID" value="XM_010705999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLB1"/>
    <dbReference type="GeneID" id="22572633"/>
    <dbReference type="KEGG" id="lpan:LPMP_090630"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090011500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_090630"/>
    <dbReference type="eggNOG" id="ENOG502RYNE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="251100at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="783" mass="84247" checksum="48F9667DAC6FB95C" modified="2014-11-26" version="1">MPDQYDQLTRLCTPTRAHNYPLPIMPRASFSRAPVGLDGPPASASVAITGAATANPASSMARSPTTTTPGTLVSSSHLLLRRNVNDLYSFASRPQLSRQHYRQLTSRNTAADSGSAASTHSPMWKSRHRTFAGGGGIVGHTALMSSDDKKRDDSDRVAKLAQRQQQTQQSDGNLPSTEKTSTMLRRRVQYNQAKPRPIPSSLRTGSDAITVAAAVDAFYTAPFLQLACREALEREIAARLRLSVQKMSSKLHTMRMEGLKEAMAQLLQWTTQASIESAERQQEQQLQQTKSDTPHADSAAAAAPLGRSSMVLPPYDAVRVEVLGGSSPTVVHGDYHQQSPSFPESPQRRSSEAAIARCANALRSPSWDVVQHALEGVDYTSSIFNTILVPRLEVRNAMSTGVPISIQLPSDMALQWTTLPTTSRSLVGAAAGTAPQGTPPSQQNKLLQAATAVTYEEQELALRYIQGTCLMLYHQRRCCSDGCLLYYATEVFQCMRSHIDALFTSQRRELEEQEGEEQTHQCGKRNLGINNNSGSGSGGGGGGSVGGARLSGTSAATTAAALTATLRESGRSQVSVNPSLVRVVVALVDAVEAACHYSPSSLRRLVQTGGVTAMLNLAYCPFMPTPIRAAVLNTISVLLQQVTPLRRYVAASSKAQETSDSGGLGRAAMQDADPLLQRMLENAVHDNPLGRDGQQIPYSTDFGSASKFDSAVRNWFFANGLGNVIASVAQLQDLRNTFQPTSFVVPQGAAAASAVTHANMLCEGELHRKRIGWLLECMDGRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLF0</accession>
    <name>A0A088RLF0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Radical SAM protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_151500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:36347"/>
            <dbReference type="Rhea" id="RHEA-COMP:10164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10165"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64315"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="EC" id="4.1.3.44"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697525.1">
        <property type="nucleotide sequence ID" value="XM_010699223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLF0"/>
    <dbReference type="GeneID" id="22573570"/>
    <dbReference type="KEGG" id="lpan:LPMP_151500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150020800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_151500"/>
    <dbReference type="eggNOG" id="KOG1160">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271553at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102521">
        <property type="term" value="F:tRNA-4-demethylwyosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013917">
        <property type="entry name" value="tRNA_wybutosine-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034556">
        <property type="entry name" value="tRNA_wybutosine-synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930:SF1">
        <property type="entry name" value="SAM DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08608">
        <property type="entry name" value="Wyosine_form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00284">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01071">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="56"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN96872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="416" mass="47470" checksum="9CC99DCB9572A135" modified="2014-11-26" version="1">MQKGSATGCRPMLSEKRREALGTMYSLVGTHSAVKLCRWQKSMMRGRGGCYKWTMYGIKSHRCMEATPSMACANNCVFCWRLNSNPTAAEWKWMVDEPKEVVEGMISSHQALINGVRGMPGVTDEALEEALTPRHCALSLVGEPIMYPYVNEFLRLLHAKSMSSFLVNNGQFPDAIRKLAPVTQLYLSVDAPNKKTMKILDRPVLPDYWERFNESVNSMREKKHRTVFRLTMIDGFNMEPENLPEYKELFDRGQPHFIEIKRLTPAFSGNHNTILRIKNVPSWEKMKAFAQQLCNMIDKGRQYTVASIHEHSGCILLAHQRFVCNGRVHSWIDYDKFDTIIQDPERAADMVPEDYLLPTPTWALPDSPAEGFDPAQKRYISNKRRKHMESTAAPPPKHNGRCITTDEATAVQSAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLT6</accession>
    <name>A0A088RLT6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Axonemal dynein intermediate chain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_150530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697428.1">
        <property type="nucleotide sequence ID" value="XM_010699126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLT6"/>
    <dbReference type="GeneID" id="22573473"/>
    <dbReference type="KEGG" id="lpan:LPMP_150530"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150010500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_150530"/>
    <dbReference type="eggNOG" id="ENOG502QR7A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10255247at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035253">
        <property type="term" value="C:ciliary rootlet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097542">
        <property type="term" value="C:ciliary tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036158">
        <property type="term" value="P:outer dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033192">
        <property type="entry name" value="ODAD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46518:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46518">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="264"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="562"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="658"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="201"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="329"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="433"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="563"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="678" mass="75205" checksum="FFFFEFE4BC2BBEAC" modified="2014-11-26" version="1">MTLNANAVEQISKTRQSVLDVGQRNQLEVVQAEVRRNNEQLTMLRRENKELRLVLQQTIRGQRNISVEDHYAKEEDLLHNKMCVLKRSINAVKGKNAELLKEIERTTEENHFIQQEGNGVLEENSTIAHKIRALENRLDKCLVKHNEVQTIRRTYETLLERLQLEQAGFNTQVSSTEQALQCANKELGELVAVWKSAAKARDAAKAEVSDLKAQLAAERQRQRKDLDERRAFIESKRQQLAKKHEAILLKLTQQEERHARILQSADGVAGSSARRRGHHSRAASAASLSPDEVEQLQAQKTAYLRLRDVTMGTNVSDVLAKLRERSAHHVQLQATAAELEVSMQQLDNEKSALQSEWEEVNHRAGHALVSARVMRAARDIRGGADNENVETCGADGKDGEGNSSRNAAAEVGGAEAVDYGLLADRCHERHLVLEEFRQHLHQRQDELEEAEEKHNGLAQLLREVDLGVQYLAEKLSISAALPVAANAATDVSAAPQQHQNQRLATQTSLTNDLLRNCGAKLHLMLEELSPEELDAVVRSMSTAKFLIPGTNVRVPEVLEAQRVQRQQQTSSASPARMSPSHVGGASLSQASMGAQGDGPSPTTRHHGSVDSDTQAAGVAASGASAAAVAAVSLVDDYPENEIHDRQELKMMSMAIVEREQQKARKRQMQQRRTKEEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMA7</accession>
    <name>A0A088RMA7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase GlcNAc-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_170990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697790.1">
        <property type="nucleotide sequence ID" value="XM_010699488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMA7"/>
    <dbReference type="GeneID" id="22573842"/>
    <dbReference type="KEGG" id="lpan:LPMP_170990"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170016200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_170990"/>
    <dbReference type="eggNOG" id="ENOG502QWH5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="76265at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021067">
        <property type="entry name" value="Glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34496">
        <property type="entry name" value="GLCNAC TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34496:SF11">
        <property type="entry name" value="GLYCOSYLTRANSFERASE (GLCNAC)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11397">
        <property type="entry name" value="GlcNAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="638" mass="71930" checksum="A5ABA7F92B3AD3CF" modified="2014-11-26" version="1">MRDYSQVPSVLKRPLRMPRRRLSVRRRQAILAVIAILCLCVLSFMYFLSTSPVNEHRKFSDIPSKPWFTAEENATRFAQVVQGRTPGTTWRDATFNMILSLSKSGDTVYMTPTNYTRYRRTTDGNPGDFRKWESIYRPGDRYHVPAWATPADRATLHHASIFVSLASFRDHECALTLRNLFDMSASPHRLYVGVSEERRSSDASCLSRLGMDDLESGETRRVLYGAEAPASLGVEVRTLTWADVLAPRRLLDVDAVLSTPAVSAEGIGVEPDGVFVHPAHAAERVLCVAGELETARDTLLTGEEDAKSAIAGQSVFRKGRGGPQQQPSRALAGCRVTTRVTDASHARGPTFGRYITSLFFFNQDYFMVVDSHTRFSVDWDMKLITRVFQLPTRGVLSNYPNGYREGHDREEFEKTDVMFMCTAQVLSNGMPKLGARWMPLSPRPVLQGFAAAGFMFGDAQFTLDTPFDPFLPYMFDGEEVLYSARMWTAGWDLYGPGQPDVFHHYSRPNTPKYFGIMTPKEAARRLLSEKRTLYLLRRAQPWIEELVHRGYVSPNGQSTLKPLPSAPPPETRLIVTDEVASATREINVWSKYYGMGAERSVSSYWQHTELSDEFVKTKDNENRWMGGIGLCEKGAALM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMT0</accession>
    <name>A0A088RMT0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ARF-like 2-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_180120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697846.1">
        <property type="nucleotide sequence ID" value="XM_010699544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMT0"/>
    <dbReference type="GeneID" id="22573902"/>
    <dbReference type="KEGG" id="lpan:LPMP_180120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180006300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_180120"/>
    <dbReference type="eggNOG" id="ENOG502S6PN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="302784at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1520.10">
        <property type="entry name" value="ADP-ribosylation factor-like 2-binding protein, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042541">
        <property type="entry name" value="BART_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="127" mass="14579" checksum="C941C321AEF51AB1" modified="2014-11-26" version="1">MDTEEGEFLICGNGGSPEDAAFDTVVGVIEDFMISLDLEKMWQSVPPLHTISDEHEQHTVYRSFVEKVDQELDAHVLAACPVYKSIDEVVALLQRRHEDITEEVWAFVSEGCFDYEAFVEQWKEKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMU7</accession>
    <name>A0A088RMU7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_131370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697217.1">
        <property type="nucleotide sequence ID" value="XM_010698915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMU7"/>
    <dbReference type="GeneID" id="22573247"/>
    <dbReference type="KEGG" id="lpan:LPMP_131370"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130018400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_131370"/>
    <dbReference type="eggNOG" id="KOG0372">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273392at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF514">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="3">
        <location>
            <begin position="334"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="21"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN96564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="546" mass="60514" checksum="651977DFA8BBCF83" modified="2014-11-26" version="1">MQPIFALISNSSVLQRTFAATSEKSQGSSVQVPSTLDSAGGATTSEGDGHSSGTMPLIVRVTKSGTEPLQGAPPVSPPRRVSEIPESFQKRPPSIPWKPRFFPNSAGSQSPLGVETHLSTPVLNNARSSSPVCNSPCSSTEQTKEQESSTKSSSLTFKWVECDTSLSSLSVSQEVEWVEQKQTNAFFRVTPRSGEFVPLIEWLLRRGERGDVDAPAASQEDGGECTQAHFFSEDYLMRLCAAATAVLEKEPAVLELEVLEHDTLVVVGDIHGQFQDLYTSVLCLQYDRHQCNLDGRDRRFLFMGDYVDRGPHSLQVVLLLLALKVEYPTLVYLMRGNHEEERTSRVYGFLTEVTSSLGAATGAAVWSAVNKVFLDLPLAAIVQSLYMRFFVTHGGLSPTLQKVDDISRIDRRNYSCGNITADEDDIITGLLWSDPTNEVTMYDRNPRGCGFLFGTSASYTFCADNKFDFICRAHQVTMEGYMWMHNHHVVTVFSAPNYCGVNRNKGAVLVVKGRAWKPIFEQYDRADKDEKALARKEDFAFAAMFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMZ1</accession>
    <name>A0A088RMZ1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">L-gulonolactone oxidase</fullName>
            <ecNumber evidence="2">1.1.3.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_171320</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-gulono-1,4-lactone + O2 = L-ascorbate + H2O2 + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32363"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17587"/>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
            <dbReference type="EC" id="1.1.3.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; L-ascorbate biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.8" evidence="2"/>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697823.1">
        <property type="nucleotide sequence ID" value="XM_010699521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMZ1"/>
    <dbReference type="GeneID" id="22573875"/>
    <dbReference type="KEGG" id="lpan:LPMP_171320"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170019400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_171320"/>
    <dbReference type="eggNOG" id="KOG4730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="610608at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003885">
        <property type="term" value="F:D-arabinono-1,4-lactone oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050105">
        <property type="term" value="F:L-gulonolactone oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019853">
        <property type="term" value="P:L-ascorbic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000033">
        <property type="entry name" value="L-gulonolactone oxidase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2520:FF:000005">
        <property type="entry name" value="L-gulonolactone oxidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007173">
        <property type="entry name" value="ALO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010031">
        <property type="entry name" value="FAD_lactone_oxidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762:SF1">
        <property type="entry name" value="D-ARABINONO-1,4-LACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762">
        <property type="entry name" value="L-GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04030">
        <property type="entry name" value="ALO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000136">
        <property type="entry name" value="LGO_GLO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0060">Ascorbate biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="8">
        <location>
            <begin position="17"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="265"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN97170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="498" mass="56117" checksum="0DD16B40FC449FE3" modified="2014-11-26" version="1">MPLQLPASRWTNLAGIGLCHPSHHHYPTSTEDVQRIVEFVRSQKGKCRVAGGGRSPNTATFTNEHLIHMEHMSRILSIDTVARTITCEAGAVMEEVMKSLDKVGLMVRCVPSYVSTTVGGCIATATHSSGIRCNCLSDYVRGLKIVDGCAMIRTLATGKDDAELRLAACHLGVMGVVTEVTLEVQPRVQWKVVSQPLSMTDATNTALVAEKVKSTEYYRWWWVPHTEGCYESYGSVEDVPDMSPKSPLRETLGLQCETPVKPSPAASRTASNTSDSADSSTSLVVKMVLKYIATDFVRHQMVEWSLWAACLYPNLQPYVNKAYQRVFYSAPQVQCGSALECFTFDCLFKQWANEWAIDASRAVEAFNRLRGMVDREGMLLHFPVEFRFTAPDLSDMSPAVGRSTCWIGVVMYRPRGREARDTHRCYQGFCRLMEEMGGRPHWAKYYDWGHHEITAAYGDHWKRFLALRRRMDPDDIFVNRWFSNLISPDRVNSTECAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNF2</accession>
    <name>A0A088RNF2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_190230</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698018.1">
        <property type="nucleotide sequence ID" value="XM_010699716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNF2"/>
    <dbReference type="GeneID" id="22574077"/>
    <dbReference type="KEGG" id="lpan:LPMP_190230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190010700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_190230"/>
    <dbReference type="eggNOG" id="KOG0239">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000146">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972:SF28">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VHS" evidence="8">
        <location>
            <begin position="57"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Kinesin motor" evidence="7">
        <location>
            <begin position="501"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="307"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="281"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="582"/>
            <end position="589"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN97365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="838" mass="93484" checksum="5A138AD3D065914F" modified="2014-11-26" version="1">MNIVANRGGPQAVASSAVELEVNELIMRQMSSRNPDGDPDATARLVEHIRHGNGGFVLEGIRQHFKYKPPATQICMITVMDQCVIQSGPQFAVMLSGDKWTDRLFKVAKTTSSAEVRDKIMCTVIKWYQLYHTNGHQRLIQRFQQSRVLGEPFQNIFSKMLKDKQQPANNPQQNFASLNNTNRNDILDTEEAILLECQGDLASLEYILEHPSVLADKEIVQECKQHKLACIRMLESGDHSRIGNELMSLIERFTEALSLYEAMAGFDIGDGQSSKRRALGDEDLAETDSDDDDVQRQLRLRRGGGKRADAAEVMKKAQQETENLMNRERGETQHLRLQLEELRQKHEDLQNKYKDAKAKNKEAVSMLEQYAERVELLETGGNVDSSHLTPLPVLGASPLGARGAAGTTRSMQPASTDHMRSLVTSIRKCQREIKEVLCSDITKQAQLFSAQMSNAMAAMIQASDVDRKADQMALQWTQELYRREMRLRKTYYNTIQELKGNIRVYCRVRPMLQREIDGGHKDVMSYPSQDEVKFVDASGRPKLFEFDEVYPPTSPQSRVFEDTAPLIDSVVDGFNVCIFAYGQTGSGKTFTMNGTEGENKGINTRALERLFEIIEERKDTETSVVMISVLEIYCEQIRDLLATKKEAAGLTYEVKQGGPFGTYVTNIKEVPVTSPRDIDSIMATAQTHRSEGTTNMNEHSSRSHMLLYIIVRTTNKQTNIQSYGKLSLIDLAGSERVEKSGAEGQQLKEAVAINKSLSALGDVIAGLSQNAKHVPFRNSALTFLLQDSMAGQAKVLMFVCVSPASYNASESSSSLLFASRARGVAFGQIKKNATTAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNW6</accession>
    <name>A0A088RNW6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoside triphosphate hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_202810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698484.1">
        <property type="nucleotide sequence ID" value="XM_010700182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNW6"/>
    <dbReference type="GeneID" id="22574491"/>
    <dbReference type="KEGG" id="lpan:LPMP_202810"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000010200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_202810"/>
    <dbReference type="eggNOG" id="ENOG502SAUJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="445357at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="248" mass="28301" checksum="A6BC7DE878614DA7" modified="2014-11-26" version="1">MSGVGAALVKKLPILRESRARNAVVSIFCVLAIIVVRFLYRYVHPLPKGTKRISSRSSRSPQKKKHNSRDDSDRSSGEGDRSTKQRKTDSLLPTVLMLIGIHGSGKSFWAKRYTEIVHKSYIIVSSDAIRSRLTGTIDNFTREDEVEEKLLEEVTRTLELRRSCIVDDCQHNLSPEFRTKLKALAVNGKANRVVKIFSVKPSYAMMRIQSDVEEGIVRYIPTMVEIEKQVERVAEFEKTYKDDGWVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPK1</accession>
    <name>A0A088RPK1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Calpain-like cysteine peptidase, putative</fullName>
            <ecNumber evidence="5">3.4.22.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_205360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.-" evidence="5"/>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN98027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698734.1">
        <property type="nucleotide sequence ID" value="XM_010700432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPK1"/>
    <dbReference type="GeneID" id="22574748"/>
    <dbReference type="KEGG" id="lpan:LPMP_205360"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200060500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_205360"/>
    <dbReference type="eggNOG" id="KOG0045">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="424753at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015232">
        <property type="entry name" value="DUF1935"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036310">
        <property type="entry name" value="Smp-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF423">
        <property type="entry name" value="LEUCINE-RICH REPEAT PROTEIN (LRRP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09149">
        <property type="entry name" value="DUF1935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101601">
        <property type="entry name" value="Smp-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="4">
        <location>
            <begin position="317"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="21"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="548"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN98027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="815" mass="91221" checksum="7F65D1366224F7C7" modified="2014-11-26" version="1">MSQAGERGEWQENCEEQFTLFSRPQDAEMTTYASKQSETPAPEEYGEELAEHAPQQSHPPQYCPEDSEAQVVPQQAYEEEAPQAYPEETDDYYAAPQHAYEEVAPRYVHAAAPPSAIVKPRTRNVKSVARWEPVEYDPRDGSDDEFELSTCMAPVYEGEGEGGSEDASVLKHGGPDCKGEIMSCFDEPNLLYRIIDPKKKTWAFYNDSLHYEMHVQFTFGKYSKLQPLENTTMRQNEEGQYVMEVVVYPTETEMFAQGSVNGFTSKLCAVPLTDNYHNARRRITEEQVSNEMAAIQQATGSDNAEEVLQACIENGIPFVDPEFPPCQASLDAGAGKPFKPLAWARPEVCVPEEMASQVRLFRGNVRSGCVDAGDLGDSWVMCSVASVSEDPARLMGMFRHPEGKAAAQREHAVGAYRVTFNKNGWWRSVLVDSYLPVSGGKLKYAKSATDPAEIWPAILEKAYAKLHGSYAKICSGDPLHALQDMTGFSVMRFDDSLADKTSNQLFSDLVRGIAVGYTVICSTPGRGPQDNDQDLSEAYAQAGLVTGHAYTILEAKYIESKDLRMVRMRNAWGRGVVWSGGWSDDDTKWDENPDIAEECNFQKADGTFWMSWKDVQKYFNGGGVCFTHQPGYDYRMNCVFTDGVPSAVLEIEVQSPAWFTFVISQDDRRCQVNASEYKPVMISIAEPVEGDMYKVVMNSSANGARPTSDKWTFLQARDISLIHKLDVGKYIVVPRIMPLDDPIEPVPYVLGMICNKEVGNGDVSVMFKRLDADNRVFENFPKFEPELMEVEQPVQYQKRAPGEGFPMTQMGEELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPM8</accession>
    <name>A0A088RPM8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD-dependent epimerase/dehydratase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_202890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698492.1">
        <property type="nucleotide sequence ID" value="XM_010700190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPM8"/>
    <dbReference type="GeneID" id="22574499"/>
    <dbReference type="KEGG" id="lpan:LPMP_202890"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200034200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_202890"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000644">
        <property type="entry name" value="NAD dependent epimerase/dehydratase family, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="484"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="4">
        <location>
            <begin position="116"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN97785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="510" mass="55823" checksum="9411897A23970AA2" modified="2014-11-26" version="1">MFRVFSGSCMSLEDMDTVLRSNLVEHPHLLGPGADFFTESGEPVRPQPGAHTFQKVFSGSALDLNANNAEGSDEEVAASSSLGQGPRAIPPSSILNQISTENEKEKARAAKMKIHVLVIGESGYLASHVIAKLLDAGYSVRMTVPDAARQQKQIDLYGASRDVAQRLTILQADITNSNTLRDAIRGCRYIVHCGCSSASPQAKDLVTFYTKAIRALFDGIRLSGKSTVKRVVLTGSASSIVHITECDPPSGLFDENNWNNVATPEDDPLPYAKLVFEREAWRLRQMMGVELVVLLPSISIGPSLTDETSEAMVTIEGLANSSKYFPFCPNLSWNFVDVRDVADAHVRAMEVAEVRDQRIIISNECVSLPELCRTMKQLCPQLTPPTHTAWTVVTLGIATLVLWNSVNLRFLWRSLGVRKRLNNRRAKEQLGITFTPMQQTLRDCLEQMTRSAKVTADAEAAAAAQRSPANGRRKSKVAPSSSRLVSPTVMFSLLTLAAAGATVVHYVKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPU8</accession>
    <name>A0A088RPU8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tubulin-specific chaperone, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_180680</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TBCB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697902.1">
        <property type="nucleotide sequence ID" value="XM_010699600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPU8"/>
    <dbReference type="GeneID" id="22573958"/>
    <dbReference type="KEGG" id="lpan:LPMP_180680"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000022100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_180680"/>
    <dbReference type="eggNOG" id="KOG3206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01789">
        <property type="entry name" value="Ubl_TBCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.190:FF:000013">
        <property type="entry name" value="Tubulin-folding cofactor B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045172">
        <property type="entry name" value="TBCB_Ubl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF85">
        <property type="entry name" value="TUBULIN-FOLDING COFACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14560">
        <property type="entry name" value="Ubiquitin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="5">
        <location>
            <begin position="176"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN97249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="232" mass="26246" checksum="3E7CAF48FBA7FEA2" modified="2014-11-26" version="1">MSVVKVAITHSASQRVVPEKSYGLAQTVQSIKDDMYSRFGIPAEQIRLELYDTRDCKVEGDMKDEKLLGFYGCETGYRVHVVDLRPTAQVENYDDVSKVEKYVMTDEEWLKRPDNLRAYKERMLALQREEMTKAGIEVPTGPDDDSYKAEAEKMKVGDRCCCQPGERFGTVRYVGRVAALKPGYWVGVEFDEPVGKSNGTVKGVTLFECLPLYGGVMRPDQVKVGDFPPEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPV2</accession>
    <name>A0A088RPV2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_210310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698819.1">
        <property type="nucleotide sequence ID" value="XM_010700517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPV2"/>
    <dbReference type="GeneID" id="22574853"/>
    <dbReference type="KEGG" id="lpan:LPMP_210310"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210007700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_210310"/>
    <dbReference type="eggNOG" id="ENOG502S6TX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272484at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="552" mass="58303" checksum="B93355B294BFA76F" modified="2014-11-26" version="1">MYRVFPILILRAAKVRAQYLQLGSLNDSYTSSAAPSSSTLVAAAPSATNVYTLAFGEREGLAPGERLEVYGNTVRLVRTLAYGCPRGVTPESAFTGRLKDAELAAITEQLDVLRWQTRKSDATVHTGQSVYASGPAHSGMTKSVGEESLHPSEWIVRVPEATHSRVLQNAVPNETQTCAGRSLAAQLSKLRASEEEVVVAEWVGKSKGDWEATTGISAGASAWSPRPSSAEASTRAEQSAAEKTNPNGSSAGGLSILPTTPLKSGAALPPGAGGILLMENGVCFRDPGSCGLRALRTARLAFISSIEHTANDLARRQRRQTCEEARGLAVLDANAIDFTFAQAALQSTLELGLHTGAGCQISHVPLTDAAAAHVEPQAASYIRVVAAGPGRRLPKPFGYLPTHSIDVGAYTAHLPLPVEPAAGESMGKEEDSGGGARPAASRRGCKSPGRDTITDRHQLALQLSQALATLRRGACMLVTFVPTCSSIAALYHRIEAQRRAELLIEHQVVMEAKACIAEAIARTGRWGFITDEVLPAADSPQGSSFSLIVMLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RR17</accession>
    <name>A0A088RR17_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_231020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699259.1">
        <property type="nucleotide sequence ID" value="XM_010700957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RR17"/>
    <dbReference type="GeneID" id="22575307"/>
    <dbReference type="KEGG" id="lpan:LPMP_231020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230016900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_231020"/>
    <dbReference type="eggNOG" id="ENOG502RQB6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272606at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="786" mass="87544" checksum="BFDE7652286B41B3" modified="2014-11-26" version="1">MPRYDSVSRVGAATLEAIERERELLEREELMYPGYTTLRIQELKHTVTNKASTQAELQHAADALREELDGLLEVVGREVEKPMSTQRLLLLKWQQRQQRLQNRENAFQTGPSSTPAFRVVLQADGTEVIERPGRDTPRAPVHETEDAYLSQAVEAEELSPEALIPEKTIVTTADVNHVRYLLGLTYRRLKRCDEAEKVFYDVLADDVTNVDAIESLLELDTGIEGWVPRIRVLLDYLNEGYAKVLQEGRLQPATAPNKLPIIDAHCAEEPCAELSPDAPTTSTPTPQQSSSPSSSMSPEAAVTITAGADVARAPTPHYTTLPQVSPVEVALSILSDLIVEAAAQKCSTDGEGAASRFFIEAMDPIVRVLDRDYACLLLEALFRAVDEQHFAVRFDSDDISPAARKFALSLVIAFLKALMARRIYEMLPQSVRFHFFTLVKLHTALRSAGRVHESYKICEQLMQLYRANSSVYRARVHASPRAAPRPSPLPAISPSPSSLHCKCSSELGVSAARHGSVAPTDVEAQNAAAAAAARVPVPSLQEVSASCAPTVDPKGVVEEVPPTESSQCSEPPDILDDQDANYREALFQYVNDRAHDSPALGRRLCMEAMAEFPACAAPWETLALLIHKEDPKRNLGDAIIAARRAMELEPFNIRVIVTLANFYKASHRYELYDRMMDRYRLMSYMVEEGASEADMVATAAEIAMLDEQTPQAQDLVEETGRAMKEFLERMEQATTYSMPIDKEPRLLRDGPMRFITQQPDMRPAEVEAHDKSLLRQIQMLESWQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRB6</accession>
    <name>A0A088RRB6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_221510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699152.1">
        <property type="nucleotide sequence ID" value="XM_010700850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRB6"/>
    <dbReference type="GeneID" id="22575197"/>
    <dbReference type="KEGG" id="lpan:LPMP_221510"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220018700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_221510"/>
    <dbReference type="eggNOG" id="ENOG502S4ZB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272371at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="808" mass="85693" checksum="B03D068B48578CE7" modified="2014-11-26" version="1">MSCIGAFSAYRTAIAAHLPFPYLGYSHAFLGRTREPHSPALGSPCILLLTFLFPNLLRGGPFPLNSPPIPTPEAALTSFLRTSDGVSALLMAVIATLPAASWTRLLYICRDVVAACDSKTAYLVQHRGDTRVDEATCTSPCEADHFVPWLPLGVPVAGVRTVWCMRKGQSNVVFAEPAGEACGTAATSPDTAAIEIISGLADNIISMHIFYQSVLAVRTLKRVLFYSLDPSPSATTIATQIGACALPKWVNQPAVVVDIASPSCCCATAEKTICVACFTLGRMFVATVVCPSSTSAVVVRRTAMSGVLFSSSGVPDPAAMRVCKWAVRWSRQEMIMLCFSEVDKISRLTGFFLQPTRGCEMSKWMSPEELAASVSGASAAVVGASRDMCSDSDGAHVWLCDTSTGPSVILREVTAASPNEVVLADTNASLRVAMAAGISGVFVLSGCTLYAVKSGHTGTVSAGTAGRAITAAAGDLSREQERRVQKEPPAAEAITTKAAASERFSLSAPTPSTPLQPAAFTATTAASLPRSAHIKDAVLQYVSGDAPIFSYIVRDAVYVHESGSATSGMTFTHDILSRINARFDADRHQHALACIRYATVALSLHPYTVLELLRFRRRSSVEVAPEGLLLAIASTLADKPTLQHGGLRRLPAFDTASTTFFASTGGGGPFTSELEKKRYVADVCGAAKAALANGALGATRLLFTVAARAVSLIYGGTRKRHVGATQSYGEEERMCEVVIAECISLIRSYVEWSLTTSSSLGVMSAHVGSPHTLTKEAALRDGEAHFIDTSRQVQIHPMQVSRQPKRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRM5</accession>
    <name>A0A088RRM5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vps72/YL1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_241190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699459.1">
        <property type="nucleotide sequence ID" value="XM_010701157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRM5"/>
    <dbReference type="GeneID" id="22575528"/>
    <dbReference type="KEGG" id="lpan:LPMP_241190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240018100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_241190"/>
    <dbReference type="eggNOG" id="ENOG502S5J8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273846at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046757">
        <property type="entry name" value="YL1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05764">
        <property type="entry name" value="YL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps72/YL1 N-terminal" evidence="2">
        <location>
            <begin position="10"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="325" mass="36003" checksum="75F46CEDDC9EDE46" modified="2014-11-26" version="1">MEWADDVVDRPRRANAGNRLQELLANGLDEEEEKALQALSDASSDTSFTLGSDEEAMDEVESDFDAEEVGGTLEGETVETEAMVRRAERLGRQLERRKKLQRSQNLSKMAVRDRAQRPQRTKKQEKRHRDTDDTDRFPRQRQPHKGGAVSENDGEDGEEDGDEDGSDDVIDLRQRVRRRLAPTIPCSQRLAEAHTRAAALREAQAAAEVHRDGHAEDESSSSGGAGVMHTRRGLSTGKDQQRTRRPQCNSSSRARRSAWEATAALSTPVDGSMSGPLPVFVSPRIALYEGIPQRVRYSSGTSVLQRFHVPTVVSFSAALPPVLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRQ9</accession>
    <name>A0A088RRQ9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_204300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698631.1">
        <property type="nucleotide sequence ID" value="XM_010700329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRQ9"/>
    <dbReference type="GeneID" id="22574641"/>
    <dbReference type="KEGG" id="lpan:LPMP_204300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200049100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_204300"/>
    <dbReference type="eggNOG" id="ENOG502QSF8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276630at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="269"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="575" mass="62897" checksum="C954D4854B03CEA2" modified="2014-11-26" version="1">MNRGVAVKIKYFDDNGGWSERKGAAASSAVFSLKNITVANVDMNHVDISDVDRLQDLVVTSAPTAVVMQNVSPATLSRIKSYSQIRKVYAVMETSRCEQQEESTVALLRLGLQCEPTEVPKTDGKQAFRALVQVNIRIPNGPSLSITVLHMEPGASRRLTFAMALLRAHPNVDIAVLLSNVTEGMVLTEDPYRELQVNRAAAGFVDVMEEGMERTTNWSTPWTVWLKCPKYSVVASAAELFVGQEPRYLSTTLVLRGQPNSTIAIPMPRSAKSGRGKSPSGPPAPGTPSQPLADPAILSAETVKTLMPTPQTSSSATEIIQRLMRQQQASQPRWKAAHSFVLKGSDTKLSTAETMYDASSHFANANDAVDALNSKALNWPAEFCVVQNTVLCADTVSHCDRQAFRRYVRDNKTNVSLSSQLFAATTAFAAAVAAAPVITSVTAASVGLPAGAIPGDKQWPKATNVRSEMEEFLNFQRQLKESVRREWSESCCVSVYQITPREMKFNITPAIGLAKDNLKKAIHYLNHAKAASKETNPLHDYPYDYALLFSVERQGYWLIAATNVPCDIVACRMVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RS12</accession>
    <name>A0A088RS12_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">fumarate hydratase</fullName>
            <ecNumber evidence="5">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LPMP_240310</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(S)-malate = fumarate + H2O</text>
            <dbReference type="Rhea" id="RHEA:12460"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="4.2.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:12461"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:12462"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I fumarase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="5"/>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699372.1">
        <property type="nucleotide sequence ID" value="XM_010701070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RS12"/>
    <dbReference type="GeneID" id="22575440"/>
    <dbReference type="KEGG" id="lpan:LPMP_240310"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240008300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_240310"/>
    <dbReference type="eggNOG" id="ENOG502QT04">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="411469at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.130.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.130.10">
        <property type="entry name" value="Fe-S hydro-lyase, tartrate dehydratase beta-type, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051208">
        <property type="entry name" value="Class-I_Fumarase/Tartrate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004646">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdA-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004647">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdB-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036660">
        <property type="entry name" value="Fe-S_hydroAse_TtdB_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011167">
        <property type="entry name" value="Fe_dep_fumarate_hydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00722">
        <property type="entry name" value="ttdA_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00723">
        <property type="entry name" value="ttdB_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30389:SF0">
        <property type="entry name" value="FUMARATE HYDRATASE CLASS I, AEROBIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30389">
        <property type="entry name" value="FUMARATE HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05681">
        <property type="entry name" value="Fumerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05683">
        <property type="entry name" value="Fumerase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001394">
        <property type="entry name" value="Fe_dep_fumar_hy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117457">
        <property type="entry name" value="FumA C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic" evidence="13">
        <location>
            <begin position="63"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-S hydro-lyase tartrate dehydratase beta-type catalytic" evidence="14">
        <location>
            <begin position="342"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF05683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AIN98665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="549" mass="60711" checksum="7193C136E7F57E39" modified="2014-11-26" version="1">MFRRITPLLSEFNFVPLVSKVSHKETKYRLLTKDHVSVVQPGAGLPEMLKVNPAALTLLSSVAFDDIEHLMRSSHLASLRKIFDDPEASDNDKFVALQLLKNANISSARLLPGCQDTGTAIISGHRGEQVFVLGNEEEALSRGVYEIFQERNLRYSQNVPLSMYDEKNTGTNLPAQIDLYATKGMEYSFLFVAKGGGSANKSFLLQESKSVLNPKSLRKFLKEKLAMFGTSACPPYHIAVVIGGTSAEMTMRMVKHASCHYYDDLITKPDMKTGYTFRDLELEKEVLEICQNIGMGAQFGGKYYAHDARVIRMPRHGASCPIGIGVSCSADRQALGKINKDGVWLEVLEMEPSRFLPDVREDELLKTPPVEVNLNRPMSEVLQELSKHPVKTRLSLTGTIVVARDSAHARMREMLEAGKPLPQYMKDHPVYYAGPAKTPDGLPSGSFGPTTAGRMDPFVDLFQSLGGSMVMLAKGNRSRHVTEACKKHGGFYLGSIGGPAAVLAQDAIKKVECLDMKDLGMEAVWKIEVQNFPAFIVVDDKGNDFFQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSF5</accession>
    <name>A0A088RSF5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_250430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699615.1">
        <property type="nucleotide sequence ID" value="XM_010701313.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22575691"/>
    <dbReference type="KEGG" id="lpan:LPMP_250430"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_050010200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250008700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_250430"/>
    <dbReference type="eggNOG" id="ENOG502R14G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266868at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="584"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="652"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="743"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1077"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1178"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1279"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1375"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1445"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1505"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1579"/>
            <end position="1624"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="167"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="584"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="652"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="686"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="786"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1077"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1095"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1178"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1377"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1523"/>
            <end position="1532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1598"/>
            <end position="1622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1656" mass="178421" checksum="B2C9618D631A4851" modified="2014-11-26" version="1">MSSEGVNSLAQRVLSLEDIIRQQEQTISAVLQRLRDVEQYAAAESRSREQAQQLLQAAFGNHNGSTAETLNRMQALLQSHNDRLSTLQAEVQGQGAALRGTNDKHDVAFREMEKRLQADLSGAHQRAQTGETASAEAMRALQAQLQSMANVTQAVETRNHDDLVALQQQISAELAMQRQRCDNLESAIRDALRDVHGSLSGDVRSAGAQQRSDLEAAVQRINQELEALSQRTRIDMNQLHSTEQTDVSDLRRRIGDLEYGVREAVQAATNGLAHEVAQVAQHSQMQDKRQETAHQAILQELAKHDTQLETVDLNWRASVTDLGAKMREDVAAAQQRSVAGDQALQSQVGALQDRLVEMANKLRGDLTALATSMQENCVRPLQEAHHTLSVQGQRMSRIADDYASMQDYVTTFAAHVDEDVGQSKQIMEAAVRAAHSDLLERINLISMPNTLHQDSDMRAEVNRSLAKLWEDAKGVFLTQRSLDDIQTQLMTLESAVRVELCALAERLNEVWRTVDKHRIGELRAAQQPITPAAVTGMAPEQSSSHHFAAASAAISTVTTPVASSFTRTHRNQVSAVLTKASKSTAELPTTGATATTAAPWSSKAARTSGASSVTAKAEEIYKDSDEQNERLRQHEEDIKALWASLQRLHTAQTPELSKPASSTQWNNVSTIHPPTAAGAEVDRASIEAQSAAREAAESAKAAESAQDECVRAANELRLAVQRVSVLEESLKMQLTEAKVMLSAATPKQQAQPPQPLPRKTDKPPAASFAAKTTPPYSSPPKQLVAKGEEETAKGEAAKDAKGEEETAKGEEETAKGEAETAKGEEKTAKGEAAKDVKTGVSGAPASITPRSANRPTAHTRLSAEALATPADDLVEVPGMLTGEVFIVRKDKIDATSSASVRRRPATAGTATFLPRPMASSGALVRPTLGDNVVPEPSSHRGSSSEVLLPTHQFVRKREYSNFKDFTKREIDTIWVELLSMRRTHGLSKEEVLLYISQSKEQILGTVLNIVQQQEKEVLGILGNIKTQLTELDRNPDAVREIRVFPVDSGQNLENFVRSLSGYLKAVPVAAQAEPLSSAATAAGQPQSGVRKGVSRPATNRPAARRTGASTTATTTPLGQSLHPTERGNESGACTSHSSACSSLPVQPQLISPMVKRRASQPTLRPELQEAVCVSLEVSSPKSDSSSQRKPSHCPAPKHNFSASQQHARQYATDAVVHPQSARPARRLSEPECVVAQHQLASISSTTVQVSQAKSSPLSSEHASVGRQLLLGSRLAAASAGLGPSGGSDPCCYASPQSDHTAPPPDQLSSPSSSAVRGCTGGDLKCFLKESKSPRNSTGSSFHLNPLQGIVGSRFPSPTVPGVRRAATATGVLATATPSRSVDSESQLLEADQRQPYTRLPRCPLRGHSLSLLTTSQAEAPDAPLPKDTSFEKYESVTICQESETSYQSVGSMRPLRSGVQHRSVDSMDGTSARGGISAACVREPRHLYERQTPMPGQYRSLSAQFPTPMAQPHPRGYSPARDGSSTSVSIDTNPPRRPAQVHTTAVSGTIRLGPYRKPPGDDTNNLTIASRTSISSCIDHTPHVNVSGGRNDDRSTRSMHSALQSLDCSTPNQPHSSATMPSNVVPVRVLDNPVNRSDDSSSLDRSLVIVHPYNKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSS0</accession>
    <name>A0A088RSS0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_212020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698986.1">
        <property type="nucleotide sequence ID" value="XM_010700684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSS0"/>
    <dbReference type="GeneID" id="22575024"/>
    <dbReference type="KEGG" id="lpan:LPMP_212020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210024100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_212020"/>
    <dbReference type="eggNOG" id="KOG0181">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03750">
        <property type="entry name" value="proteasome_alpha_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1 2 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="4">
        <location>
            <begin position="4"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN98279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="231" mass="25148" checksum="F732FAB257C0FCBC" modified="2014-11-26" version="1">MSEAFYGLTTFSPSGKLIQIEYATTAAGKGSTALGVKATDGAVIAAKKKASSTLVDASSIQKVFVLDEHAGCTYSGMGPDCRVLIDSARQNCQQYRLMYKEPIPISQLVRKISALYQEFTQSGGVRPFGCSLLVAGVDANGYHLYQVDPSGTFWTWKATAIGTGSSDAKAFLEKRYTVDMELEDAVHTALLTLKEGFDGQMTPENTQVGRVTENRFEILSVDQLRDYLDQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSV2</accession>
    <name>A0A088RSV2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Starmaker</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_251900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99053.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699760.1">
        <property type="nucleotide sequence ID" value="XM_010701458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSV2"/>
    <dbReference type="GeneID" id="22575838"/>
    <dbReference type="KEGG" id="lpan:LPMP_251900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250021100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_251900"/>
    <dbReference type="eggNOG" id="ENOG502S68S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267831at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99053.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="885" mass="96281" checksum="A7D8F7F87EEC8F7B" modified="2026-01-28" version="2">MSKALPPIQDHRPASVEQSHSYSRYSARGSRHEEHQRFYASSARVRSLSPGATADSHFTGFSTLPRLPQVEFSLGPIQERNIPPYNDLEDPHLVPYWARKVMLIQERAAQRRRLRRQQAMEEQRMAAARRRFLHRRHQEREEMASRKGEQTRQREEEERQSTTRGASKNSRHAPTKPSAARRSGATAGGRSRQQAATHRYYEAGSNLHAEEVVERATGGLPADHEYVTSSSSATTIRSASSHSDAASGYSNRHHDEEYYAKEDGAAVPAAPPLTEEEEKTYPDEAGYSTEDMNRDAEPEDAVKEVTSRSSILKSSSSFSSSYSSDRQSSLRNHAAEVAREQAKAEARAEAEAEAGAYVGDGAEDSYADDGFEDNLSQSHHQSSAAAAYLCPQEEDGKAESLLEPEAAYPLETTEEEAHKESYDDDEFEKSFASRDAADDVEGAPAAPLQQHPEYVEEEEAEKPAAADEASDDAKSGSYEKERLDDDELLSPKKASHNTSDADVSLIEKYEEDQAEVSPEDAQCATATLTATEDVKPSEKDDIEGSAAEVQSQEEYPQTALGQGDGEDEFEDELSTSKSSAAAAYLCPQEEDGKAESLLEPEAAYPLETTEEEAHKESYDDDEFEKSFASRDAADDVEGAPAAPLQQHPEYVEEEEAEKPAAADEASDDAKSGSYEKERLDDDELLSPKKASHNTSDADVSLIEKYEEDQAEVSPEDAQCATATLTATEDVKPSEKDDIEGSAAEVQSQEEYPQTALGQGGGEDEFEDELSSNKSSATTSVAPSPVAALRKADVPKEEVGEELDRELSPTKAPDAERKREESLMSSSALAPAPPSPSSSNSEVVTASTSAVSPAAATSHKNSAAGMETEELGSGADDTYADDFEGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RT27</accession>
    <name>A0A088RT27_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome production factor 2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ribosome biogenesis protein RPF2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_260030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
            <location evidence="1 4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the RPF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699825.1">
        <property type="nucleotide sequence ID" value="XM_010701523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RT27"/>
    <dbReference type="GeneID" id="22575906"/>
    <dbReference type="KEGG" id="lpan:LPMP_260030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260005200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_260030"/>
    <dbReference type="eggNOG" id="KOG3031">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="407658at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039770">
        <property type="entry name" value="Rpf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728">
        <property type="entry name" value="BRIX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728:SF0">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="6">
        <location>
            <begin position="33"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="326"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="348"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN99118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="362" mass="40282" checksum="6782A35D4D6D2703" modified="2014-11-26" version="1">MSTVGDFKRRTAKSSTTRRALKQYEPKVIENPKRVLFLKGASLTDVVSHAMVDLMAITKPYCKKLAKKNAFFPFEGRQHLEFLGFKNDCSLFCFGSSNKKRPNNITIGRQFNFHVLDMVELGIVAADRLDMSQTVGIDAGSAGGKPFFVFEGSEFASDPAFLRLKSLLIDYFRGGNEIVINLDGCDRVLFFSLRSQNGEDACVAPSTDCYTNKPPSEKGNAVLCMRHYALKKPSATAGAPKTLKNIQLFDVGPNFDFEIRRISFATPQEFKVACRIPRETLATLRSTAGNVHADGLNNLRGQLHVGKQDMHELNLRRFKAHRRGMAAGVAENEEGSTETAKQPRRRARVEAEVGDPRPETDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RT30</accession>
    <name>A0A088RT30_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Proteasome assembly chaperone, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_251970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699767.1">
        <property type="nucleotide sequence ID" value="XM_010701465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RT30"/>
    <dbReference type="GeneID" id="22575845"/>
    <dbReference type="KEGG" id="lpan:LPMP_251970"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250021800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_251970"/>
    <dbReference type="eggNOG" id="ENOG502S718">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="259603at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018788">
        <property type="entry name" value="Proteasome_assmbl_chp_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053720">
        <property type="entry name" value="Psm_Assembly_Chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31051">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31051:SF1">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10178">
        <property type="entry name" value="PAC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="191" mass="20537" checksum="206709173B6D7C95" modified="2014-11-26" version="1">MNSSVSDPPQVATSSDATPERSTVELQPAIRQRTIAFCFPNPRSASSTGTAAEVENDNADGGIRAVLHLSIRGFVDYLLLFVTEAQTCAPGVLLRYDAPAVGPSAFMYDDETPSLDFTVLLGLRDHPLTNLLASTIAHRIRRYGETRPLLMGLSVVETAKELSSGRAKKLFLDYAASNLLELAGEAQATPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTV7</accession>
    <name>A0A088RTV7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Small GTP-binding protein Rab1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_270760</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700165.1">
        <property type="nucleotide sequence ID" value="XM_010701863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTV7"/>
    <dbReference type="GeneID" id="22576252"/>
    <dbReference type="KEGG" id="lpan:LPMP_270760"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270014500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_270760"/>
    <dbReference type="eggNOG" id="KOG0084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01869">
        <property type="entry name" value="Rab1_Ypt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000359">
        <property type="entry name" value="Small GTP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057289">
        <property type="entry name" value="Rab1/Ypt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN99458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="200" mass="22281" checksum="7C887C1AABCE0F15" modified="2014-11-26" version="1">MTAEYDYLFKLLLIGDSGVGKSCLLLRFADDSYTDSYISTIGVDFKIRTLNLDSKVIKLQIWDTAGQERFRTITSSYYRGAHGIIIVYDTTDMESFNNVKTWLSEIDKYASENVNKILVGNKCDLVTKKAVDTQMAKDFADSLGIPFLETSAKNSTNVEEAFIQMASGIKTRLAVSGETKSVSRPNLQNPPAPKKEDNCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTZ7</accession>
    <name>A0A088RTZ7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Retinoic acid induced 16-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_271160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700205.1">
        <property type="nucleotide sequence ID" value="XM_010701903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTZ7"/>
    <dbReference type="GeneID" id="22576294"/>
    <dbReference type="KEGG" id="lpan:LPMP_271160"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270018800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_271160"/>
    <dbReference type="eggNOG" id="ENOG502RS4H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272562at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="935" mass="102040" checksum="F74D2220D6C2440C" modified="2014-11-26" version="1">MVLVIQEQWLQLCEYFQRVQCSNRYDERVSLVKELGSVEQALSVILDALLKDRMTLVTSHPGLHRPSTALRCSFRSDSTPPSPTVADTHSSYTPPPSPTSSRDMGARGATKTMTTAAHTGTSPSSLLSSSCLLNGLDGDCLALPPCYRFLFANAHSVSIPLPPTSEMEAASRANDAAASYDDPPPIGNIFLLTLCQYAKQDEPPGVRSVILGFLVRLLQEADLPTDRSTYPAGDPGMSLLQLRPSVLIVPLLDMVRKVSKALDPSNAAALRSPTALASASSSTAAATAAYQWVMNDLHDGTLLQDAGRTQLVIFLSTLAEKMERVPALANFFVVEEGSQERNLFVLLDTLLPYLTHDCGTREWTHRRDTCRFALSAVVSLAKCPDPWIQDLVARETRVVSRTLNAARTTLLTLCKIPENDDSSTQRLYLRDVLRFWTTLATMAPSVAATLRLLPLIEEEFVYQTVLPLLQSSDNHVYSAACVVVSNILADLQGAAPLLKAFFAKALLSTTIRKANGSIVPNKEFYEVVVQDPVTAAGAARTGGCAMTRGQQETKAAMSLSEHPTTSFFTYYILPHLSSNPCLSEEDKESNVVLGFTTTRWSATKATLLLVQTLAEHVPHVFLREVFLMDVTSLSDVERKQMACASNPAEPWGTIVTPPHLNIHDCFLSTLHSAAVMNAKIGLQPDCVGEAVLSRLLRVESNMPVAALRARQRMMSAMTLPCSTSATANTATAEDAAPVSCWFHAGVQTSPLITALCEMVQHLDLSPYTVSCLVADLVVSLVVMPDLRVLYTLLDSKQGPLVTALRGLRNLLRHHLERKVTEPSPIRKDMGGGGASRSASTTARPLAVSIPFLYDMLLQHWDLLVTDDDAVRITPATPDRSSHSSEVSFESLRDAIEQHRSVLYACLYSEYMHAHLDAVIGYTALSQNLMYLKMSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RU18</accession>
    <name>A0A088RU18_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_240960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699436.1">
        <property type="nucleotide sequence ID" value="XM_010701134.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22575505"/>
    <dbReference type="KEGG" id="lpan:LPMP_240960"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240015600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_240960"/>
    <dbReference type="eggNOG" id="ENOG502SK1U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267051at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="640"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="676"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="969"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1180"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1266"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1381"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="509"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="696"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="769"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="816"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="854"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="899"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="997"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1266"/>
            <end position="1279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1539" mass="163373" checksum="92A44DF7F3F1EECC" modified="2014-11-26" version="1">MFAATSPPPSTSSWRHHVQDQEEDLVREIMQANDVDAVLARMENDHFRHLTPIIRKLSSYDAAVSATPTSPRAGAPPTPPPPPEPSVPRTYGGGFRGSVGWDAQPSPSILQSSHSYVPRSYRAASPVPTSLHIGMDDNDAPARIFPAVRQPPPPPPMQASPSPVYGTVAHDSLDAYRRPAGGAATAAPHLEDCEAESRYQRTIDSWMWPGAGLRTSLSAASQQLHVDPALDPAAAVSSRLPPPTPSSSWSPTEDRYQGNAGARSSRVTTRVTSAAPPRPFVSLLGEAADDPGGLENAAQSRIARQLQLLRNYRQLAELCSSTDSPSTDLFRTLPSEELARMQMEQIKGLAQRAQSPITVNNNYYFDSASGDKHDNSRRSRGVDGGQSLSGSDNPLGAVRGKPNTGMAPGSHRSASDTLTADNSLLGVARYRPCGASSSQQQRPPLLPSPRAVPLQSPHPSSEPDSPIVTPPLSLRGGNLAPPSPSRSQRGRSHCSRLFDAHYTPTATTEEAGSSYGEGSAEDEDGDDHPGDCMDNGGSENNEEYDDNGTGYRRPPPRIIEREQHRRFPNASIGDDALPSSAAGGTAQSLLVPYTLQPEHKHQNSYSGHYANSQSLATINEHLYDTGNCVPPGMHSCSTAFTPSDRRNNVSGAPGSDGGRCSVSSAINVLSGDQELRANAQRQSAGVRSSHDDRRASQQLAGSSQHSHQQQRRSLSMNSSPVALHGSGALTDPCVSPNRLSLHNLRRGSRERDGGLQPSPTPVSRNGGNAEHRVRTTPTPEKRPTVRSGTNGVTAPGSRGDRRRKERSGPDVTPSSHRKDETRRGGGRRGNDSDDDRYVNSVRSGTYDSDSDDSTCNTPGNPQLQTHKPPPSAQRQRQTRRRHREPRPSLGGGERGSRRRGYDDCDGKTRFGHKHFSAKARAYPTQRGRRGGGENNGGVDNVWPAASHSCSYTTDSDISDYVPRSYYSPTRTGHLGGGRRGARGGMNSPGRSARAFPQQRQPYVSSARSSAAQGHDGRGGRGSAAQALYSGRGRGGAMLGSYHSGVSSAAALGVGYGGHQSLGSPRRYRAVARGGVSGGNCSPYYGGGELSLKLGAHQQHRQQGCLHRVMDAGARDPRMPMVGGSAGQGSGMVRLPGGRVTAVASPEARQYQPAMRRTAAGVPVAHVVAPIKMQQQQQQMGYTPSAGAHPLGPPYAARLSGRPSSTAPLSIKSGRAASPSVAPSVAMAACSNYGAGGSGPHVQPGLLYGSLLPKARLKTALVVEEDEHGRSRSVDPHGDANHTPLLERGSICPLQSVRSSSIQPWRLGSDVTSGADIFPIAGVAINGSTNTGVLPLAWKSSGSGCVVGRTGHIPVAPRGNLSSHYVPPGSINGRKQPQYLPRQQPQMATVVGASSPAPLPSHLLNNAARPTAASASVTGIPSPQKPPPPQQQQPGYYRLHSTDAGPRDSLLSLHISRPQYNEPPRPAEIHNKVMQPRPSRFSGGNAQQRYAPLQGPLEKMMPGRRETALQQQLGTYSSSNRALATRNANAQRFGITALQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUA4</accession>
    <name>A0A088RUA4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aurora kinase</fullName>
            <ecNumber evidence="11">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LMAIRK</name>
        <name evidence="13" type="ORF">LPMP_280530</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="11"/>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700394.1">
        <property type="nucleotide sequence ID" value="XM_010702092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUA4"/>
    <dbReference type="SMR" id="A0A088RUA4"/>
    <dbReference type="GeneID" id="22576498"/>
    <dbReference type="KEGG" id="lpan:LPMP_280530"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280010700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_280530"/>
    <dbReference type="eggNOG" id="KOG0580">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="377346at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14007">
        <property type="entry name" value="STKc_Aurora"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000887">
        <property type="entry name" value="Aurora B kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 11 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="31"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="158"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="8">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIN99687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="301" mass="34852" checksum="8536C28FC77655F9" modified="2014-11-26" version="1">MTTEVGPDDSVVNNFIITPPSPRSEWTIHDFELLHKLGGGNYGDVYLASVRKSNYVVAIKKLSIKKLAEFDIANQLRREIEIAFNTRHKYLLRTYAYFFDEHDIYLILEPCSNGMLYSELNRVKLFPPPTAARYVAQLTEALLYLHQHHILHRDIKPENILLDHNQNIKLADFGWSVHDPLNRRKTSCGTPEYFPPEIVSRQMYDMTADLWCLGIFCFELLVGHTPFVCKDNDQIYKKIHAMQYTIPDSVPPEAKDLISNLLVREGSKRLALHRVLNHPFLLKYYYVPNGITPPTGKRPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUR9</accession>
    <name>A0A088RUR9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Leucine-rich repeat protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_282750</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700614.1">
        <property type="nucleotide sequence ID" value="XM_010702312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUR9"/>
    <dbReference type="GeneID" id="22576720"/>
    <dbReference type="KEGG" id="lpan:LPMP_282750"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280034000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_282750"/>
    <dbReference type="eggNOG" id="ENOG502RZUC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1574204at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF56">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="587"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="748"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="823"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="699"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="148"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="588"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="769"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="823"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN99907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="870" mass="95734" checksum="3AE7711896AE3DDF" modified="2014-11-26" version="1">MFNSAHAVLDFSFAPGRDRDLSDLPFEARMLQELAAEEVRELNVTHAQVLSLTSAPGALINDVLQHVTVLRAAHNSISSLHGIEAFCALEVLDLRHNRLRVVDAHAASLLRTLKQLRSVDFSYNNMSLFDLDGSVGAPSSRATGLGAGAAPSSSRSGSGNGSGRLSLSIVDPSDSLLSLTTMNLSHNAFIDLPSLRSTPCLQVLNMSHNRLDALVDFDMRLPLLSLHSLALHSNQLRTATSLVPLCALAATLKHVQVFRNPFTLMQSRSKAAVGTITSSGPAHQSGGALDESMWWRPFLLWLCPLLVTVDQVEFTAGERRVAGVMLFRENGLLSRSRLEYMNPQRKDDLEAYLRRKSESIMPPHDAMTIIDNIERQEKLQECSRGVRESDTGEVGQMVLPISRMNPPRIREAAPPHRLTNGILTTSPSTYHDPLAPDVVEPSTAETTWVAQSSPGAGDATNRSLSGGRVVMFTGETPLCMSPHPNAVLAPNHSHQRAPPASMTSFVRAVQRKLRSLEEVVAVLWRADLSRRIAAAIVIQRYMRGALARMHLSEEEAECCRFIRYQLQQTTVAQAAHGVSRRAAHVGARDAGGASSGSVATRSANQRHSSLEPAEDTCSNMQEILISMRSLQEVMSNMWADLEEYRAMADREQRRAAVFIQRHYRGYRARCEYGRVLKHRRSSPPPASSCTTACQCASETASLQQVVSELRSEVRELRELLQQKTHQQRLATCGDPEKAIDEIVRKYEQRSSAAQLAEPTDPPNLDDDTQPSSAMPSFTEPTVDVSASQEKAATFIAQDQGLLMKGNSYEEGAVRVSKNMPHFTEQTSSLDSTPQKRDYVPGQPTLITKPRPRLESMENARQAGNECVKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVG0</accession>
    <name>A0A088RVG0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_261160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699936.1">
        <property type="nucleotide sequence ID" value="XM_010701634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVG0"/>
    <dbReference type="GeneID" id="22576019"/>
    <dbReference type="KEGG" id="lpan:LPMP_261160"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260016500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_261160"/>
    <dbReference type="eggNOG" id="ENOG502RY0G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273651at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="681" mass="71088" checksum="9FDFB3491165E237" modified="2014-11-26" version="1">MPVEYPTENDLPHGSSEEEEEEEEEEEEDEDEIEEWTEMVPLSELEELEDGPSSYFVGGFSVCSYLGDAIDRVQFKEDVVLVFPGVYAAASSSSPSSSAPLELNEAKLGGLCVYSVSYASEHGGSEKMTEPRYASPSKRRVGPWFTYLTAAATAVFLVQGGGSGGAESLKSRKAYNPLQAAASKAAAALDSQDAAATTAMNTTSGSSVFAPAITATTANAQLYPVFDFLISIVYKDGSTGVAASSTCGLPHYVPQQESDKGDESEEGEETGETSGDGGDGPEQESQEPAAGALREEAAITLAGVCARAGVMIGSITRTHITHCVIGSPQQHQTSSEAGAVAPRIAITAAPLTEALVDYCLVYGGSSYGLYAYPRCALTMRSCIVEGPNAAAVAYNTAGASVISKPPAGSGREGSAIVQLQRRQARTQLLRRYMDRFDEGLDKNTGNGARGSTSLDVEDGVLPRFCVPGASGAAAAAIPIPCEVGIMCDDADVHIEDCLVTHTRHGVLLHGGCTGTVVKGLSVRSIAQVGLYVYGMAGAADVQYSSVHACGEACLLVVGPSAAQVLAAEAALPTRPSEESEEEEDGETCSGHTRRRPVFAQHPHIRSNWFIGAVRVQGEVRSGAMVDNLIFLPRDEKRVAAAASAAAQTLLTVTANTARGFAYVGIEGERAPARAADEAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVQ9</accession>
    <name>A0A088RVQ9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nuclear condensing complex subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_292660</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CND3 (condensin subunit 3) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700870.1">
        <property type="nucleotide sequence ID" value="XM_010702568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVQ9"/>
    <dbReference type="GeneID" id="22577029"/>
    <dbReference type="KEGG" id="lpan:LPMP_292660"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290029100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_292660"/>
    <dbReference type="eggNOG" id="ENOG502QW3J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27187at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000710">
        <property type="entry name" value="Nuclear_condensing_complex_subunits_-_C-term_domain_containing_protein_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027165">
        <property type="entry name" value="CND3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025977">
        <property type="entry name" value="Cnd3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418:SF5">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12719">
        <property type="entry name" value="Cnd3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear condensin complex subunit 3 C-terminal" evidence="8">
        <location>
            <begin position="558"/>
            <end position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIO00213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1043" mass="117141" checksum="FA92CED0E9429ED7" modified="2014-11-26" version="1">MGSHKKGAVVSPTSTFEEVGRIFQQVHQSAAHAQKCKSKLISLGQQSAPQLCRDVCAVVLLVMRQVAQITPEAMRRHYAFITELCKAFRESFESDQLAIELLKSISVFHNAIDKAVRLAVVSTFEALLRTVDQNNASEERQDFYQEAAELLKQRVHDKCPQVRAKAVASVAAFQSGKKDCDVTQQLIALLCCDSNADVRKQILHAIAPRKEFLEGYFHSMIRCIRDVVARVRAEAWDALGRFPWRYITAYASAKGVKMPELLATGLDDANASVVIACRAAITNCWVHRDCKEAYEDFMNSIACGYVLPSLPPYERISAVLLAYAQKRKTGTHFFLKLDDINTAGLFLWKADCQLSCDTEGEDETQLLPPLEQFSAVLQDTVYAYARPDAEPRTVKFRSVEDADNMLRILLSVFDIYDDNAYLAHADNTTRASLLRLINFILKVVPDEDPSLFLDVTVRALKSLTARTPEESTKTITSALDSLFRSLKLPQRHTLGFEDVEAIGRKSRERQQELVRRKVLWRAGELPEESYTELKEEMDRDEKFLLRMQLIVLEFLSHSQRGDAIPMFCYHIIQMGRHLDNESVRVAAIKSLCLQCLINPESVHTFIPLILADSHENAAAKTACPEGTGMSLPIAAIGVIFDLIMEYGLRFFDVEKQPPKETRAVYNAESEIEARLQHEQKLAEEDVHKVGSKRLLATLQSYLQPGSEAKHTITASGFCKLLSCNRLPVEVVSHVITVLLIHYAGAMASKKESTTAAYMVDYLGTFFRSYAASHPKRQVQLCEGGITAFRVVLERNIVMASKLIEFVARLIDAYTLTVIRDIDPQAAKRATRDVVDETADVAEEEEAQRKSNRINATRSSMQSGRLFRELSRYSLHERLSQELLVELANSELVEGRSVCMDVLERCMYFYSLEPQPFLLHCAAAAMQATRHTDPILHDRLEAWQARLRQRCAAAGAAPQLHGTVSDAESADSLEQRWNEAVKARTERRDALLEAGFGGFASIPPQLDVASPVVVKVEAVELKRERYSDVFGVESIVGPRKRSRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RW10</accession>
    <name>A0A088RW10_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LPMP_292270</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="11"/>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700831.1">
        <property type="nucleotide sequence ID" value="XM_010702529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RW10"/>
    <dbReference type="GeneID" id="22576990"/>
    <dbReference type="KEGG" id="lpan:LPMP_292270"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290024900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_292270"/>
    <dbReference type="eggNOG" id="KOG1046">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275509at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000033">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000006">
        <property type="entry name" value="Puromycin-sensitive aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF299">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11 15" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 11 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="14">
        <location>
            <begin position="15"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="12">
        <location>
            <begin position="229"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="13">
        <location>
            <begin position="521"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AIO00174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="868" mass="96657" checksum="BBB197C5B5DFCC4C" modified="2014-11-26" version="1">MSITKNVKLENPYVPAAYHLSVTVDLSTWSYKATETVHLQRCAACRDGDTIQLHAAPSIEVTSVKGATLVRRDETAHTLVLKLDAETIALADPTLHFEFKHAINKEMRGFYQVCFKHDGKEHRMASTHFEPVSARLFYVCHDEPAQRADFTLTVTLPKSEEHYIVLSNGPRISKEMRGDTVVHTFQTVPKCPPYLTACVVGELEHISTVVNGIPVSVYATLGKAGRAQFALDTTAFALQYFEKFFQCRYPLPKLDLVAIPDFPIGGMENWGCITCAESILVDSKQSSVDAKRGASNLLCHEVSHNWFGNLVAINWWEGLWLKEGFASWCGYYATHVRAPQWNALDAAALQVVWALKDDMCEHSHPVEVHIRDPADITQIFDSISYNKGMGLVFMLQAFLGDKWAPAVAHYINKHQFRDTKTVQLWEALEESSKLPITEALTSFTTQMGYPMIHVTRQSESAIVVGQEPCCFVTASEKSKQTWCVPLVVEGIDAAAGRATTMLRGDKALEVTLPVGIVSGAFVNINPHRTGFYRCRYDNSTFDAWLANYDLLSPADRRSLFSDTFAAIRMGYDDVPRLARIATTVAAHEQDIYVLCEYVQTMSAFLRSFDDVTLTKSLSRELLGFLVPASETFIEFIPQDDTASLRRNFYLDAGISTLLNSWELAEVAAHPLILWALQQARSFLSGAEFNAGTLTACLRAWVRMASAAELPARNEQLYAKLQEVDGNDELCRSLVVAMTSGSSVDFALGLMKRCIENDGVRSQYGAHVFSSLAANPAFSGAEVWKTFQSHFDAVDAQWGGGQFRIQGIVTCLGEALFGEAAADEFEAFFETHPLPNARLAIGRATEDLRNRAWLNKKWKVSLTQTFCRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWJ8</accession>
    <name>A0A088RWJ8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_280550</name>
        <name evidence="7" type="ORF">LPMP_303160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS26 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700396.1">
        <property type="nucleotide sequence ID" value="XM_010702094.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701338.1">
        <property type="nucleotide sequence ID" value="XM_010703036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWJ8"/>
    <dbReference type="GeneID" id="22576500"/>
    <dbReference type="GeneID" id="22577369"/>
    <dbReference type="KEGG" id="lpan:LPMP_280550"/>
    <dbReference type="KEGG" id="lpan:LPMP_303160"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280010900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_280550"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_303160"/>
    <dbReference type="eggNOG" id="KOG1768">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262653at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1740.20:FF:000003">
        <property type="entry name" value="40S ribosomal protein S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.20">
        <property type="entry name" value="Ribosomal protein S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000892">
        <property type="entry name" value="Ribosomal_eS26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038551">
        <property type="entry name" value="Ribosomal_eS26_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01283">
        <property type="entry name" value="Ribosomal_S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN99689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO00538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="112" mass="12806" checksum="EE78CC2CE5FFC3E5" modified="2014-11-26" version="1">MTTKRRNHGRSKPPHSRGRVKPVHCFNCGRLTPKDKAVGRFVVRRMLDAASARDVAEASPVYGANFPMPKLYMKQRFCIACAIHSRTVRARPVESRKTRYTKKVPFRPVGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWN5</accession>
    <name>A0A088RWN5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_302260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701249.1">
        <property type="nucleotide sequence ID" value="XM_010702947.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22577279"/>
    <dbReference type="KEGG" id="lpan:LPMP_302260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300026900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_302260"/>
    <dbReference type="eggNOG" id="ENOG502RY7B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="247078at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="178"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="539"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1074"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1262"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="943"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="552"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1267"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1291"/>
            <end position="1302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1308" mass="141142" checksum="8EB55FA7E7CC82C0" modified="2014-11-26" version="1">MMDWRTEAYRAIKAFDDALGRPPFPVEAPEDLVVKAQAVLATLANVVAAGKLKSLDGVDEVTTTLPILCASLREGTPNHTPCLYLYRPLLLAAAHVSSLSTYPISYLLRDAVQVLAPQEAPSPTGSSVKCAVTTTPTETSRKIDDSETEVENEVTLFTFMALTHSLTPMYMRRFLRSPPYEPSADGNRATRKEGKGSAKQKVVAPHKGDKKKAHLLSPPTSASGINGGGEVGGNTLAVPRALLHCMIGAALSDECRAVFESFVDNTPKFLACVAGDGDLARRILDVYAARIVPKLKPSSLLPCLDAPLLDYYVDVVAASQGAGHVTLLSSHEFREVPRRTWDAARFRRLACAAMSRTIGAEDAMASLLVYVYLYLTYCDFSWDKTPTAPPPSSPAAVEMGTAMSVTEAHLITAVCKASNAVLLADSAPSSSAFVSSVCVQLKTGALLVEGSAVPGALEPLQVFGNLLLTRPAAAALWRGGLVRELERETENADGIMATLTASASLLERSVLGVLEGILRDAPRPYQGVCSPSKRQQQESAKCGAAKSKRKQQSASGKGCSSSHINAVSGSPTSRQPGDTAEALPAPIPLSKLLSGCCTCLALTTLGATGAEASGSEGLSPVHSLRNQDGRALDCVVRAYDYLLQHQSQRLNAALWHNFNLFVTCGMWQWAMAASCSDTEGRAMAYLLSMRKLLSAPSTATVLTALTADTGSLLWMSPLLLSSYLSLPPTSNAVAEMLSQVLWGSPCRALWIAILRAAASGESVGAGAKATGPSPKTSPLMQELHPTSDTFLFGVLCSQWSHAVLADVAECVATATVGGGDCAALMTSLIRMRTSGACACEAVLPRTCVLTLECVPASLSQHGLQRLLDEVGRLQAQYLAREKSARQEEEAEGRRRILEQLQSIQALAEAHRAFCEAAGAKCAARADEHQQVQEELQRRRDARVARLRADAAALEHKRQVALETLRRKAVQARADADAARQRRFASCQRRLASEYRVSTFLEHLQLPLARVMEVRDALRTVADRITPDDLLEYLVSGKAKVPSDMLGEDDALDANDEADAKDAAANEGNASIYERQAEHQAAGTSSPRPRATGERRDFWADVMDGVSTTARTPPLDNQEGIYRQTTEMAPALAMTTADIMGAYSLHTQSFHARIAPLMDLFCYEGGDEFGHVPDALPILHLRVASRVWPASQVQLLGFADVREAFERMRDRGLVRIHDDVAQLTLLGFRYHYPFHNPEGMLAVHLRESQARVRMLVESRNELLRADNGSEEDNEDDSDIAAENGEKNDEDEASAHDREDRVLPEVEFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RX13</accession>
    <name>A0A088RX13_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">39S ribosomal protein L28, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_302680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701291.1">
        <property type="nucleotide sequence ID" value="XM_010702989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RX13"/>
    <dbReference type="GeneID" id="22577321"/>
    <dbReference type="KEGG" id="lpan:LPMP_302680"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300031500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_302680"/>
    <dbReference type="eggNOG" id="ENOG502RHTE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="361870at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribosomal_bL28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L28, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL28M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO00491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="27403" checksum="EEEBD66F84F1A926" modified="2014-11-26" version="1">MLRQSSLWRFSTFALNPETSRAPHGPPRGLINRYISMGLPPWAAWCNRVNRHALYRLSDVSPRSFLPKAPQEMDVIWMNERVRERVRTSRQVQHVYRQLKYPFVKTGIHYSDMLDHWVQVPMVEAAMFEIEKDGGFDNFILRRSGPELRSTYGERIRRHLLVRQKETQKNFVLDQQAKTLAEVAQAELMKAASEEELNSILAKYGMDAEEFKRLMAKRVMEQRKSVAATDLHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXA9</accession>
    <name>A0A088RXA9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Calpain-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_310390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00629.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701429.1">
        <property type="nucleotide sequence ID" value="XM_010703127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXA9"/>
    <dbReference type="GeneID" id="22577465"/>
    <dbReference type="KEGG" id="lpan:LPMP_310390"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310008900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_310390"/>
    <dbReference type="eggNOG" id="KOG0045">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="424753at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015232">
        <property type="entry name" value="DUF1935"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036310">
        <property type="entry name" value="Smp-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF423">
        <property type="entry name" value="LEUCINE-RICH REPEAT PROTEIN (LRRP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09149">
        <property type="entry name" value="DUF1935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101601">
        <property type="entry name" value="Smp-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00629.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1498" mass="162438" checksum="887F37D76F45BB10" modified="2026-01-28" version="2">MPKVPLAVVSTSSDDSEMMCSDPAGSFKDANWSVMKMDSFDSLPFSEVSHTPYGTDSNFLDSVSHGGSAGYRPSPGAPFALERQEAVTTSFKPAVLSPRPGISRGFRLHGNDQSTSTTEVSTVVVPTLPAVPTHFTPKCSDALVSRPKLCGLGGALGTASAVAAALSRKKKPKPPPYRTRSLKIEAAKWLEDDHSTEMLVLREVSKRQLGSPIADDEAGDSLSLSSSGTVGLLTPPGQDVTPFSSLVTGLQSAVTGASSLLTAALKAKKEVTDDSPTNPTEGRRAPTVAASTTKDPTLIMKAPATMSTHTTLTKGDATADSPLWLASRINMVPPRRIAPLHGKKGPVAGVPTNSAAAATVQQQPETQLSKFPDTTPPTGTPRLIRRATLPPAEKIATAASTTDVAPPSSVANSLAEVSSASTEENFLAARRELRRPQPAPGSQRPVELFEAPRAGAQGADGVKGKPAGRFGLQSKVLSPDVIAMPPVGDDKPASLQVQPPPPNTSTKHWLRSRRPCLRSTAAPESSGVGSRPVRGAAKKDPSRISPAPTGLQHVVQPFELGSTEVALIESTSSLTADSVLPEERPKTRQYGLADSLQISPANRVAAEKLVAFVCAVSDPEVLHVVYDYLEEHQKAVPRYRLATSACRELLERKEEVLLACLPTSRGNPHQFTQRSAVSAHHSRGESVPQLVDSPDKKVVAARTGDNLTEAQRFLQQVEEEEEEGCDKGDDDDPYSDEFDDFNCFPTPYIPSTRFRFGQPSVSGLVTRVFAEGMLYKIKTPNGEYYFYNDTLQELMVVRVQCCLRGDEKINERAMLAPIAGTGETEVTIAVLPEETYFFMSGVAHMPHFLAKRVPVPLDYVSPSVTQSLRKTNADINAVRKLLGKWSRASDQQAYLKCCLKNHLRFTDLNFRPSAESLYRPEFDVVAIPAVTWRRPEEYINLAEVSQTRLFRGEISCFLVKQGELSNHTVVAAIAAVAQFPVHVRWMFRHPVSAHVGKMERALGCYRVTLLHNGWWHAYLVDDYVPASLRGPLFARCPEDPRRLWVQLLEKAYAKSLGSYAATCLVDTMEALGDFTGFPVRFLDSMWTAAALKPNDHSSRSLFHYLELSVRAGCTVLLFSPGPSDEQSSATVDLSRKRSSRILPVKDTVPQFLPGHIYFLRDVAFYQELDLRMAQLKNPWTWETKNMTHYEKKWKYTTWYDRPDSSLSALGSIATSLSGQVSSCGPPSHVAVPRACADLSSVKIARNEHKGTMWVEWGEVLAAFAGGGVCYTMWNRHRYRVRNAFAEGRPRLVLELKARRKVELFVTLSLETVGETLDSFGTVVASRPIPLHGTALSVVHRQASQSAKVVSESCDDIECATGCRTYIVARDVSMKVVVEPNMSSNGAAVLVVPLLDPSVVSGSVPSSGNGSALNTPSRAAVPEVRFVVSIVSDAVAGDGEDLSIHFISLRRSCGVFTDPTTTFPLVGTSHVTAQYQVCTDAGVVTCEGSRISGNEAKCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXG9</accession>
    <name>A0A088RXG9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_310750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701464.1">
        <property type="nucleotide sequence ID" value="XM_010703162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXG9"/>
    <dbReference type="GeneID" id="22577501"/>
    <dbReference type="KEGG" id="lpan:LPMP_310750"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310012800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_310750"/>
    <dbReference type="eggNOG" id="ENOG502SIMA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="261996at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO00664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="32316" checksum="E8FA79270178C7D9" modified="2014-11-26" version="1">MTKSYLSQEQQLRAEQVFITHKHLKELNLATEQALAYHDKYLAAMEKVMSCLLNNSDTIESVRTHLAEEAPVNTQPTLPMTGRLAAAYSNWRASPELKMMQTELEFLKEVSATGRHAAKKTKNAVQVLEHMAKKCSKVNTPEFEAKICSTAGKAQEKLLREQQVKNMEMVKVEKAILNDMISLATSWSTKLITRSDALYTAFAGLGHRTVACFSITAPAVPHRVPLPPAGSMPPPSSSAASLVLHRGSAATTYGTPFVQPSALSALYAAVPLDSAVEGATAGVTLEFHPREGEPPTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXK6</accession>
    <name>A0A088RXK6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_290640</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Sodium-phosphate symporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700672.1">
        <property type="nucleotide sequence ID" value="XM_010702370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXK6"/>
    <dbReference type="GeneID" id="22576828"/>
    <dbReference type="KEGG" id="lpan:LPMP_290640"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290010500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_290640"/>
    <dbReference type="eggNOG" id="KOG2493">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="260807at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF80">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="547"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="600"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="633"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="686"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="301"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIO00015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="713" mass="75601" checksum="422EC6A424A2F214" modified="2014-11-26" version="1">MDYLSTCKLDVNTTLPLVCISTLLSFLCGVGIGANDLSANFAMVVGSGSLNMKRAIIYCTVFELLGAAFMGGHVGNTIRSGIVDPVLFAQNKDVVVIGMTCASFAAALWLYLSTVFGLPVSITHTVVGSIVGFALFATGGFTYIKTNGLIVVVISWFAAPIAACGVTALLFYLLRRDIFKVKGRSFELALTVLPHCLLASLLVDFFFIVLEKPPIMSQTFAQHVPLYIQCIVLLLVMLFFCWAAKVWVFPQVVEAAMGAQSFVWESEALRTEPVNVADSSTLDEIRNFSFFKPRADMSTRTSTVAGRHHLQHHNSQRQQYQSSAADAVSAPPAVPATVALPPPSPSRSPAPASTVDSLLVKHLSGAAEDRDHSESSSTCDSPSHSYPPTPTPVHQNASLVLSSISTSDSSFVRKGAKVRLAPVHIHEHSSAPHTRTVSLSNSTTLVQHGTSDVHHLPGCKLSSSYRDRHEAKQVQSAGVVAYGSTDTTKSAVVVASGEQGLVGVPFSPVLVHSEDEFGEEDWAMDHPMRPIHFGGILIKPFNPRAEYLFTGLQVVAGSISSFVHGAVAGANATSAFVILYDTFTNNELQEPGLSSQWSVLPAMVGIAIGMFGLGASLMKTVGMELVTVTPARGWCIQMGGTFVTMVLTGVGIPVSLSQSQVGAAIGCGVLDAKLGGVSWDVVAKVVAGWAVTLIISALTTGVSMWAVSSLLCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYK6</accession>
    <name>A0A088RYK6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CNNM transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_323190</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702003.1">
        <property type="nucleotide sequence ID" value="XM_010703701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYK6"/>
    <dbReference type="GeneID" id="22578060"/>
    <dbReference type="KEGG" id="lpan:LPMP_323190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320038300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_323190"/>
    <dbReference type="eggNOG" id="KOG2118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5353557at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010960">
        <property type="term" value="P:magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000084">
        <property type="entry name" value="Domain_of_uncharacterized_function_DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045095">
        <property type="entry name" value="ACDP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF97">
        <property type="entry name" value="METAL TRANSPORTER CNNM-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="4">
        <location>
            <begin position="12"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO01203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="402" mass="44392" checksum="D6938B9711E80C9D" modified="2014-11-26" version="1">MENGYRVLGVPVDVSIWTLMAIITVLVVLAGLMAGLIISIFSLDTVRLKALACRSETVEGRRARRLLLILHNPNWVLVTLVVVDSAATEMLPLLLNVLLSPAEAVIVSVILLVVFGEIIPEAVFTHHALALGSALAYLVLVLMIVTAPVSWPVGKMLDWCVGNRSGVAFKRGQLREVIRYRAAQLDNIYGDDEEAVPLRDSDLDTREPYLMHQLETQIMLGVLSLSEYVGSSVLKKSIRATFTVHRDAVVSKRMVQSMVAHKLTHIPVYSDVGNPSNVTQVFELRLLLFFAYCKEEVSIRIRDLPLLPLPRYSADTPCNLLLDYLRASPLQVAALMSSESAARVVGIISASDVVELVHKTSFDATYVESHGPQQGNVVQSFRAHNAFMTHETNQMILNEMNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZD0</accession>
    <name>A0A088RZD0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoglycerate mutase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">IPGAM</name>
        <name evidence="2" type="ORF">LPMP_332220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702313.1">
        <property type="nucleotide sequence ID" value="XM_010704011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZD0"/>
    <dbReference type="GeneID" id="22578375"/>
    <dbReference type="KEGG" id="lpan:LPMP_332220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330029700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_332220"/>
    <dbReference type="eggNOG" id="ENOG502RXEQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261749at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052765">
        <property type="entry name" value="PGM-Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46192">
        <property type="entry name" value="BROAD-RANGE ACID PHOSPHATASE DET1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="510" mass="55415" checksum="D631A59147AAEA5B" modified="2014-11-26" version="1">MSISIRSTSQRQLARRQSLTASSSSAPLSRAALSRASHPDSAVDATPEPTALTQASEKQEPTLATALAGAHSSSCAAASRMFFTSSNQGCSQGKNIHNTSSLMPTPTLSASSASSKEAAAPSLPPSVQSSSSTAGTPRDADGAAPESLHDASVSTAFSSAAEPSEAANSQETGASHSLLYSVSRFTEPVKRIILIRNGRSEANEDVSTYVQTPDWRIPLVEEGKREAIAAGRALSELIGDDPVYFYYSPYIRSRQSLRYVLQGFDAARLSGLSHSQEWWEEESAGIVSAAGVEEPLMPNSATAPANEAGISPALAMTSSSTSTNVTFPDTPCCLHRDPSLVLNSGTSNNIIGVREDVRLRDGDIGRYTSVDELMHHLVERERYGRFFYRFPFGESGADVCDRITSFLDAFQRERVEFPMDTNVVIITHGLTMRMFIKRWFYLTVDTFHKMKSPPPGSLCTLTRLHHRSCFRLDECCVESMNLPLSLNEFNGYKYRNKQLLGSMSSGAPYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZJ4</accession>
    <name>A0A088RZJ4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_330880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702181.1">
        <property type="nucleotide sequence ID" value="XM_010703879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZJ4"/>
    <dbReference type="GeneID" id="22578241"/>
    <dbReference type="KEGG" id="lpan:LPMP_330880"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330013400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_330880"/>
    <dbReference type="eggNOG" id="ENOG502RDSN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271736at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="612"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="710" mass="78387" checksum="6DDC0B74B3BF3FA4" modified="2014-11-26" version="1">MWLRCSPRLFFHIPPLSPAAPARRVAPRTPPSHGRSRGSETASAGAATSSSRPPYTFDGRSPDDGTRRYRHHCRPSYRTLRPGDPLPPLLTNEGDCASSDGYTSQRQAYRQHRNAADNARGSPVDDTVAGSLFTPLPRPYGFYDGIDEHARQVPRPSREARLQQLRESLEEHAASAVEFTEGGEDDIELNGLPADQYHGHAGWTTIPKDSALYNAMYGVGDLESRQRTNSWSVAMRHGRVGGGGGNVSNLLGDSAAASAQRPIAHQDEDKQGNQEVLDDRRRRRQHDDGLLSVSLEGELLAPMQESVGQPRSTYAMRKLFVDGLVGYQGVITRAEEVTMSEELLHLLQDRRAAYVAEEARYCVNLYEKELGIPGKDTLAFALSSCQTLQRVLYRFFFLGLIPSVPNVCQVSEMVGTFSGYPVHRHPSSIGSYVGVLNLVSTSVLHLQHKDAPWYPRLHLTPRSLFVVTEPCLSEYAMGYKQTHQPFHAFEYATRVSKDYRIEVLFATVETAQTKTLSEAVQLTEYAEQKAREGTVKLLPGTLQPLAEAPMPTMATQTESATSVPLRGRTDEWLQRLRDNLHASEEARGDEHTKPLDGHALRRQLLAEHLVGDRSRLQSSPDGMGWGNGPDVDEGGSATAAAVQGEARHRGKDASFSATTASAAQRRLAALKARYNVAQQLKASRKWAEAADEGPRLIRGHAPRDRRLGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZL1</accession>
    <name>A0A088RZL1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-alanyl-glycyl endopeptidase-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_332980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702388.1">
        <property type="nucleotide sequence ID" value="XM_010704086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZL1"/>
    <dbReference type="GeneID" id="22578451"/>
    <dbReference type="KEGG" id="lpan:LPMP_332980"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330037600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_332980"/>
    <dbReference type="eggNOG" id="ENOG502S3AK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="299748at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007921">
        <property type="entry name" value="CHAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051705">
        <property type="entry name" value="Gsp_Synthetase/Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30094">
        <property type="entry name" value="BIFUNCTIONAL GLUTATHIONYLSPERMIDINE SYNTHETASE/AMIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30094:SF14">
        <property type="entry name" value="D-ALANYL-GLYCYL ENDOPEPTIDASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05257">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50911">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C51" evidence="3">
        <location>
            <begin position="182"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO01588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="382" mass="41692" checksum="8DA851A589C38C87" modified="2014-11-26" version="1">MRSRRTASGAAEGPVGDAAANAPHRLRSPSPPSASSSLLHSASLFGARKESDSSNADVCDAYAIRLRNEAVDAVRYRRSYWHVHCSPSILVALLIWVTIGLVVYTKLDSFHLRNGAAPTTSSAETVHSQLPDGCLDHHCLKDGGSELFGAVLGAHNGVFAYSNCNSNTCISHLEHQMEIPLPPGSRTTLDAPHATTRLMKTGMKWQCVEYARRYWMLHGKPTPALFGTVVGAADIWHSIHSVTLLDNKTTAPLLKFQNGAKLGYGGNAPRVGDLLIYPRDTLGNFPFGHVAVVVGVEMPANAEANDSYTDAEMAAAQLRQRRGLVYIAEQNWDSVPWPKPYHNYSRSLPLVVLESPEGQPLQYTIEDSFHGVQGWARYDDVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZM5</accession>
    <name>A0A088RZM5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">IPT/TIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_331190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702211.1">
        <property type="nucleotide sequence ID" value="XM_010703909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZM5"/>
    <dbReference type="GeneID" id="22578272"/>
    <dbReference type="KEGG" id="lpan:LPMP_331190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330017000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_331190"/>
    <dbReference type="eggNOG" id="ENOG502SDJN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="262776at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055920">
        <property type="entry name" value="DUF7497"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055921">
        <property type="entry name" value="DUF7498"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24327">
        <property type="entry name" value="DUF7497"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24328">
        <property type="entry name" value="DUF7498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7497" evidence="1">
        <location>
            <begin position="52"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7498" evidence="2">
        <location>
            <begin position="138"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="27879" checksum="CDCC0EC9C77B4C0D" modified="2014-11-26" version="1">MILLERGYKDALLSHRGCDSNLSCSLLCLVVLAPKRIASFIQFLFSPSCLNDPAKSYSVVFYNTEADAVPGNPSPVTCAALSVAATKLTCTIIAANGVMGMYRFLVKDTTSDTLLLGSTSLNSIAVNPPLPAVTGASGECATSSAACISGATLTIKGTNFNHRDTLYQRFSVGVTKAQRSAIRLAPTAVSETDVTATLTVADGTPAGSYPVFVEVQVCMMQMMSPLRYVGNLVLNSGSASGFNRDATNTTEIPNVPVGVNGSGAEESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZP6</accession>
    <name>A0A088RZP6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translation elongation factor IF5A C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_331930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702284.1">
        <property type="nucleotide sequence ID" value="XM_010703982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZP6"/>
    <dbReference type="GeneID" id="22578346"/>
    <dbReference type="KEGG" id="lpan:LPMP_331930"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330026400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_331930"/>
    <dbReference type="eggNOG" id="ENOG502S9JN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="64113at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="26813" checksum="54A073203ADBF2D1" modified="2014-11-26" version="1">MSGMDDRVKQFKTAAEAQLTGPALRKEINTLRRFLFRNQEYRFTKAAQQALYMAVIAHYGNAAAHHASGSAATSATPSTVVSSAEAGCSGPSSAARTDLSRGTDVLQPAGDKDGGNTADAADAPILCLLEDALKMPFTVFTSPQKDKLLSLYWTVLGTDDSAGANSGSGNANGTTSAATRTFSLVDIVDTGKNKAQLSLFTDDGEEYPQEVLVSDASALRRLREEFDKGSAISVIVRENETGAVFVSFRVDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZY1</accession>
    <name>A0A088RZY1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mitochondrial processing peptidase alpha subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_332730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702364.1">
        <property type="nucleotide sequence ID" value="XM_010704062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZY1"/>
    <dbReference type="GeneID" id="22578426"/>
    <dbReference type="KEGG" id="lpan:LPMP_332730"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330035200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_332730"/>
    <dbReference type="eggNOG" id="KOG2067">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277191at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000070">
        <property type="entry name" value="Mitochondrial processing peptidase alpha subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF49">
        <property type="entry name" value="MITOCHONDRIAL-PROCESSING PEPTIDASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="3">
        <location>
            <begin position="48"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="4">
        <location>
            <begin position="183"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO01564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="483" mass="53215" checksum="78CAEA7A0117C37E" modified="2014-11-26" version="1">MLSVSRLVRGVAETIKRENFTISRLTNGLRVITCDDGNGITGMGLFSLNGPKFEEKGSFGAAAVMESLPLRSNTRMTTEAISQSLGVFGNAYKVTNNREAMSVMLMMPRYHQREGLDVLNGMWLHPTESADEFDVAKAQTLHRSSLTSRDATSMLFELVHKAGWSGRGLGNPLSPTEEQLEELTLEKFHAFHRRYTRPERTVLAATGVSDHVAFVQEAETRLEFPEPAAPSSLLSSTETANKAAAITAQAHPYTGGCEYVQNTTAPESMNKFQEKNLSHMALFFQAIPMAHPDYFTFSVIQTLLGGGTSFSSGGPGKGMQTKLFREVLNREPNLHGMECITAWYSDGGLIGLYGSAPHEYVNNLLKIMVFQAASISQRITLAHLEMAKNQLSSQLILLGEGREQLLNDMGFNLLVHNYTITPQETIQGSAQVTMAGLHHVCSQLIEHPVTFAVYGETRDMPKYKELVEALRRSYASLNKTTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S015</accession>
    <name>A0A088S015_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_150010</name>
        <name evidence="11" type="ORF">LPMP_313080</name>
        <name evidence="12" type="ORF">LPMP_341180</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the histone H4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697379.1">
        <property type="nucleotide sequence ID" value="XM_010699077.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701690.1">
        <property type="nucleotide sequence ID" value="XM_010703388.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702544.1">
        <property type="nucleotide sequence ID" value="XM_010704242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S015"/>
    <dbReference type="SMR" id="A0A088S015"/>
    <dbReference type="GeneID" id="22573417"/>
    <dbReference type="GeneID" id="22577734"/>
    <dbReference type="GeneID" id="22578623"/>
    <dbReference type="KEGG" id="lpan:LPMP_150010"/>
    <dbReference type="KEGG" id="lpan:LPMP_313080"/>
    <dbReference type="KEGG" id="lpan:LPMP_341180"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150005000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_150010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_313080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_341180"/>
    <dbReference type="eggNOG" id="KOG3467">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="257350at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000058">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN96726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIO00890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIO01744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="100" mass="11360" checksum="C9DD5AF04392F49F" modified="2014-11-26" version="1">MAKGKRSADAKGSQKRQKKVLRDNIRGITRGCVRRMARRGGVKRISGDLYEEVRRVLKAYVEDIVRCSTAYTEYARKKTVTAADVVNALRKRGHILYGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0H3</accession>
    <name>A0A088S0H3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L18a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_340540</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702481.1">
        <property type="nucleotide sequence ID" value="XM_010704179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0H3"/>
    <dbReference type="GeneID" id="22578558"/>
    <dbReference type="KEGG" id="lpan:LPMP_340540"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320014400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_340540"/>
    <dbReference type="eggNOG" id="KOG0829">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275759at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000010">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000013">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00273">
        <property type="entry name" value="Ribosomal_eL20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028877">
        <property type="entry name" value="Ribosomal_eL20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023573">
        <property type="entry name" value="Ribosomal_eL20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021138">
        <property type="entry name" value="Ribosomal_eL20_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10052">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01775">
        <property type="entry name" value="Ribosomal_L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002190">
        <property type="entry name" value="Ribosomal_L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160374">
        <property type="entry name" value="RplX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL20" evidence="5">
        <location>
            <begin position="7"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO01681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="179" mass="20752" checksum="1F223F7F62F6A73A" modified="2014-11-26" version="1">MVKPHLRHYQVVGRESPSEKNPEPTVYKFEVFAPNFVVAKSRFWRMMKIKNKVKATHGDVLSCKVVKDAKLVARNYLVDIAYYSQRCGYTRMVKEFRDVSKTGAVSQAYHDLASRHRARYHNIEVLCVKSIPDHEVKHLSIAQYHAPNLSFPLLQRRTKAARKDRAIFVKKNTKRAVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0M7</accession>
    <name>A0A088S0M7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-ketoglutarate-dependent dioxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_341150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702541.1">
        <property type="nucleotide sequence ID" value="XM_010704239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0M7"/>
    <dbReference type="GeneID" id="22578620"/>
    <dbReference type="KEGG" id="lpan:LPMP_341150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340017400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_341150"/>
    <dbReference type="eggNOG" id="ENOG502R9EX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="412814at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032870">
        <property type="entry name" value="ALKBH7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052">
        <property type="entry name" value="SPERMATOGENESIS ASSOCIATED 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="1">
        <location>
            <begin position="99"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="318" mass="36594" checksum="5566230D1519C822" modified="2014-11-26" version="1">MSITSRFMGGVRHLLKGGSMKYLAAGEPYCPFGEEFGLTILPEYILEDDATNLRKGYVDVYTRASDRIILNDGRFQLPPLPPGSFTPLLERLEQDKVVPKNWLNNQTANLYEPGDFIRAHIDNLFVYDDIFAVCSLGSNCLLRFVHVQNGEELDVMVPDRSVYIMSGPARYVYFHMVLPVEAQRFSLVFRRSIMESDGGFRPVTTPLKEVMPYRATQILNALYSKQVGGVRVTVDDDFLESADIGAFDTSRWVKRLHPLRDWSLLRQLDEDEARVEEMREKRFIDVDFSWRYRELRSYYKAMEESLVSPHAAHVATQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0Q9</accession>
    <name>A0A088S0Q9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CSN8/PSMD8/EIF3K domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_322310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701915.1">
        <property type="nucleotide sequence ID" value="XM_010703613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0Q9"/>
    <dbReference type="GeneID" id="22577972"/>
    <dbReference type="KEGG" id="lpan:LPMP_322310"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320029000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_322310"/>
    <dbReference type="eggNOG" id="ENOG502S6N7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270109at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.250:FF:000007">
        <property type="entry name" value="COP9 signalosome, subunit CSN8, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.250">
        <property type="entry name" value="ARM repeat, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009374">
        <property type="entry name" value="eIF3k"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016020">
        <property type="entry name" value="Transl_init_fac_sub12_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13022">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13022:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSN8/PSMD8/EIF3K" evidence="1">
        <location>
            <begin position="44"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="232" mass="26407" checksum="75958C5372FAB5DE" modified="2014-11-26" version="1">MARDDGTQVVQLLSEGKYNLPMFLRYLKSSSMEGDQPDKSLLLGILLQSLARFQTSDFTACMCLVPSHVQDSPNVEKELNYIYGLENLLSCGLFARFWTQWNSVKEHLPESFHFEARVRTSILETICITMESIPTEKLATYLAVSPDQVQKVVQNALKDSEDRDMRVMAYNSGSVMFHRNRFNYPQAGAAQDSIHFTDVSSVIHNDVPRRGMAVAEETRDVRARTWARMADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0S0</accession>
    <name>A0A088S0S0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoinositide-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_342280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702654.1">
        <property type="nucleotide sequence ID" value="XM_010704352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0S0"/>
    <dbReference type="GeneID" id="22578733"/>
    <dbReference type="KEGG" id="lpan:LPMP_342280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340028800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_342280"/>
    <dbReference type="eggNOG" id="KOG2273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271164at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07596">
        <property type="entry name" value="BAR_SNX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000077">
        <property type="entry name" value="Phosphoinositide-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="8"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="418" mass="46694" checksum="A635645A8295F2C4" modified="2014-11-26" version="1">MATSNSISVKVDVPSQVKGHGALEMPYYIYPITMRLPGFMSDARFNRRYTDFETLRGQLCATYWYCIVPPIPEKESMQDKLGKLPRMVVPAKETTASEGDLLEYRRISLRRFLQRLAYHPILGKSDLLQKFTNDNEWRQCTRDPVKPPRFIASSSLEEIARSWVPSGSASGAGAQGSGGAAGSGGSVSQTGAAYQSALTQEPVDEATWKATGEYIGELESNLKNMRNLLEALVDRHRRTASAVSNFAASFGLLAEGEEDAELRGAIEGVRDCGRKVADVYSRHADSESTRLVSTLSFYVGMCAAVRETLNHMLSARQYLRSLHKKSQELQASAMRAQSANQVQVQSELHFVNEQRAHLEEDLIGAEKTFSEEFALFHENKQYDAKDMLKKFGMLELSFSESMKQEWDALRPMLESLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S127</accession>
    <name>A0A088S127_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_323510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702035.1">
        <property type="nucleotide sequence ID" value="XM_010703733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S127"/>
    <dbReference type="GeneID" id="22578092"/>
    <dbReference type="KEGG" id="lpan:LPMP_323510"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320041700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_323510"/>
    <dbReference type="eggNOG" id="ENOG502S49N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="261590at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="114" mass="13552" checksum="AD4DDDE272B56C9E" modified="2014-11-26" version="1">MGFRMLQDFMRVQRWERSIMRREDHSESRLVRGIRMIPWSGVAMFFFIMVFFGFDLGAGIKQTARRIKENKKDAQTTLEVQKVQARRWSVEQVKSFREGELPQPSWEKGGPRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1D7</accession>
    <name>A0A088S1D7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_030510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009372">
        <property type="protein sequence ID" value="AIN95286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700994.1">
        <property type="nucleotide sequence ID" value="XM_010702692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1D7"/>
    <dbReference type="GeneID" id="22571917"/>
    <dbReference type="KEGG" id="lpan:LPMP_030510"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_030009600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_030510"/>
    <dbReference type="eggNOG" id="ENOG502SHGC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267251at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="512"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="718" mass="75225" checksum="8F50C27F60389C6A" modified="2014-11-26" version="1">MSSDFESLSCNLESSENRQRHGDSTSASSDFDTLDDLVTEQNAQMLCRLDVHSASPGSGDRLAPSPDHSNQRTSSAYGYRDYGVTGEVAATVPAARGAHQHHRCSAAAQNDDCGRVHLFIKDPTSCCRPPATATRGDVKGTHTLYNLEGEFAPTVVTPRDTRTASWAAAAATTTVANVSASRGGELASVTQRQATCPPDSVSPTRVHSAATLTASATTPRTHDSSDDDGCADDGKVEKDRADLEVSLTAQRGQLTHDASAAAAASRPPQPLSTVTPYHSARDLDGFYNTGLLLEDDDNDDDAATRDLSRRHALVVDSAVAPPPPSAVPGASLFHRHRSAGRYGHNAPISWQRLPATTAAPDPYGGAHCRRPASPTSIKASTATVPRSWSIASRRKAAGDQLCRLAVVLPTMTTVHWLSLVITLLVPVNLLCLDVMALGWIRRRVDASYGGASALPSYARSTAPLSPRVVIFCGAEDSTGAAAAAAAPSSSLSLSCPSGSEFGPSVDVTTVTSTSVGGSSDTASADNSGGVGTLRPSSSSAHTVPALCSVILWLLVPNGLLCRLAMHRLRRPSSERVADETKTVDKSVVGSSPSVGVAAAAAPSTPSPPHQISVASTDEYQHLKAEWRVCCDAYERARQLAPQLKVIELFIQYAFLWVMVYAPLPCATAAGEWAEAWLLTVPAPEEETATTQNGSDWGAARNPTTLVSPRCAAGAIVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1J9</accession>
    <name>A0A088S1J9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidine phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_344670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702886.1">
        <property type="nucleotide sequence ID" value="XM_010704584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1J9"/>
    <dbReference type="GeneID" id="22578972"/>
    <dbReference type="KEGG" id="lpan:LPMP_344670"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340054500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_344670"/>
    <dbReference type="eggNOG" id="ENOG502RZPE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF33">
        <property type="entry name" value="PEPTIDASE S54 RHOMBOID DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839194" description="Histidine phosphatase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="36733" checksum="F1F5F939A5DE4D8B" modified="2014-11-26" version="1">MFFWLVVALLVAIAIVVTPVRKLAAAKCQLYAHGLVFMVKAKDLPKAYRGTNYIRMNTAGDGTRGKRIIRVVFIRHGQSVWNSLFNSYNLDLPVRMAKAAIHEFINFLTDPFGSCIIDSPLSSKGKKEAQDLASFIRTAKTKISFDPATSVVVSSNLRRAMETALVGMSPRLLVTQERIVMDSALQEGSQNIDAQSLSTEPGKIAPCKLGTITNPLELAIVFDPYLNAGNRVAGVDVYQRMDEFIMHLFGGSGEASLVPAAGGSNAALKEVIVVGHSGYFRNFFRRFLPPHSTHLSKKKKLQNCAVVAFELARDESSGEVVVDESTLKVMYKGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1L3</accession>
    <name>A0A088S1L3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_331580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702250.1">
        <property type="nucleotide sequence ID" value="XM_010703948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1L3"/>
    <dbReference type="GeneID" id="22578311"/>
    <dbReference type="KEGG" id="lpan:LPMP_331580"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330022400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_331580"/>
    <dbReference type="eggNOG" id="ENOG502RBJK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271618at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO01450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="859" mass="92082" checksum="E55261A148AB1B0C" modified="2014-11-26" version="1">MASYHPAPLPVRFDSNVSLTLHQAFLSTAGVLLCDPVARVHVVTIKTLHAAPPPSVPKTNSNSRGVAAAEGGIRMVLNSKEVAKSKPHFFTTHPSFNETFNFTVAETSALTSLSIPGHAVVDRANAAAQGRRKQVDGSVRNTSSGTSESVVDYIVVTIESADGTAFYGEAYAPFSPHCTSAIPAATPVRVMLTPRNAQDAADPLFLQDNALLEAKHLDDFGFVTMSWEVAVVPRGGALMGTEPMLTSSSSSPPSAAPFPVGLTLRATWLARTAAYVRGAHYTTSVEFGGQDRFIFSNPQQPLCLTLHGGSAEAALHRAVLHCSVQSVVDPTKSHDVAVPLPLPPLTSAAARNRDVRWTAPVRTINGVDLGLLLVTMRVSSKPLSIDPPRCPDAACTRVNDPVHQEEYQHVAELWGKSQPPQVPPGAYQPIAWESQAHVLEAAQRQRKRQCILEAQPTAEHVRHIFDVLMGRASLDAGVARVAATFSSKNPAEVTAGDLREMMVGCAFHAAQLSVQDAARFCFVALRRDVEDAVAAEEVQYIVDHCLLEKTIEMPTKERKRLVTDLFANVATVSYHDFAKYMLHNYALWATLGVPLTVDESASNVQRQHAALLHTPGAGGVVLDVATLPQPSQGSIGAPVTAGAATATQGSAVALAAALADPASSAVWRTFVVRVAQTPQKAFNVTAHAADRISDVMAMVEGSTGIKAECQEWRVVSGGAEGFGVSSTTAQKSLDPATLVGSTTLGLPSALRNGPAQFTSSTSGGNTAQEVWIYEAEETIQVRFHVKDRLHNKKDWQERLPVKEKVLKVRAVVQRKTLIPLSRCTLTLKRSNGLVTKLQDRHTLAHYHLGNGDVIEVSHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2E6</accession>
    <name>A0A088S2E6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_340790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702505.1">
        <property type="nucleotide sequence ID" value="XM_010704203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2E6"/>
    <dbReference type="GeneID" id="22578583"/>
    <dbReference type="KEGG" id="lpan:LPMP_340790"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340013400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_340790"/>
    <dbReference type="eggNOG" id="ENOG502RYPC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277550at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040183">
        <property type="entry name" value="THUMPD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452">
        <property type="entry name" value="THUMP DOMAIN CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452:SF10">
        <property type="entry name" value="THUMP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="417" mass="45431" checksum="FF07CE16D91A5027" modified="2014-11-26" version="1">MKRSYRDNKPRFHKHRQGKMLLPHNHLAGLFFTVNPRQEPRAQREAQLYLSTLTSDLEAAHKAFIKCSHVTPGTTDLAAGRCSSDQVNATASPPSASLSSLLAAELAACSTQDAHRNRFNAAKRSRAEDDEADDSPGDDDADSKPGRSDSRRDAPQRGSEWFAPLETGCKGYLFLNVPTVNATVTCPTCHAAPDLATAAARESDPVPSTTEADALTPHTIVVNPLVSRITERIFDDLAANPRPIFRNCFRLMPVELTCCPTLPEMQTALRKLLALHFAAETVDSTVAAGERVDFALHIPLPSWGADRPRRTMHTIALQLTVKNNTSVEKKKGAIVSALTAAIPANRFVVIAQPSQKTRYTVEATVCIFVAHATCAMGVQRRATERHGFNLHAAGADAFVLTSAVQVSKDKRRTAQRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2F5</accession>
    <name>A0A088S2F5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF985 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_340950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702520.1">
        <property type="nucleotide sequence ID" value="XM_010704218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2F5"/>
    <dbReference type="GeneID" id="22578599"/>
    <dbReference type="KEGG" id="lpan:LPMP_340950"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340015300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_340950"/>
    <dbReference type="eggNOG" id="ENOG502R0NE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6614653at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="CDD" id="cd06121">
        <property type="entry name" value="cupin_YML079wp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009327">
        <property type="entry name" value="Cupin_DUF985"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039935">
        <property type="entry name" value="YML079W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33387:SF3">
        <property type="entry name" value="DUF985 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33387">
        <property type="entry name" value="RMLC-LIKE JELLY ROLL FOLD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06172">
        <property type="entry name" value="Cupin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF985" evidence="1">
        <location>
            <begin position="56"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="249" mass="28082" checksum="169D2548DC0EB714" modified="2014-11-26" version="1">MCEPSHFKKRQDTESPVRPEAFPCNLDHYLHLSPSITLTSSMTDPATAPPQYTREFWIQHLQLAPHPEGGYYVEVTHSAHKVDNEAGNRRLAYTTIYFLCTTESPSHLHRLCSDETFIHHAGDPLQLHVILRDPQDENRIAVHPRAEPLAETDGADARPPYQIYRRVLLGARIERGEVLQYTVPAGAIFGCSVDTDSPDGKMGYSLVSCIVSPGFDFRDFELFTKAQLMELCPQHEAVIKEMALETIPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S366</accession>
    <name>A0A088S366_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_355080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703439.1">
        <property type="nucleotide sequence ID" value="XM_010705137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S366"/>
    <dbReference type="GeneID" id="22579536"/>
    <dbReference type="KEGG" id="lpan:LPMP_355080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350059300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_355080"/>
    <dbReference type="eggNOG" id="ENOG502SKGY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273321at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="741" mass="80582" checksum="55FEDD3EAFDCF3EE" modified="2014-11-26" version="1">MAALVETAAALAAPAVTPISTCLEALAAEPLSVKQPQEPEFSVENSPERPPDETKKEGVSTLLPTDTPDYEAASPAMSTVMGSLAYDTSPFPHAESDAATFTISASANLSLPQLTLKEQNSSLPSSVTLRNTATHLHSLTSMSPRQPTTVASVDPRVELLSLLARSDGWKTRREVGEVQYAELHRLPEPLRSKDPLCMAMRVSTSVNCTLDTFAAVQRNPVLFPEIDPELVRVMASSTLPGASCPETSRESSVFEHGAASTARTVTGGSLLLQGKGNSHAAGQVRHYQFDTNDSFQCPWKMILHCTDVELTHLEGGRYGFHTPGVPAATHVWVAAENTTGYYRGALPESYHQHMQVRVFGVVAVAVPRSADTVRVSQYMLFDSSAPLSSLHSVRWHLSFQRRTTAEFLSGVSKWMECRLNRLCRLAEEQQRRRNSNSMVALDKAPLLHFLFTVHCAEGGRALESPEAVLYGDVLARSIPWSGGGDSQRLGTEGASGDPPLLVLSTVFPCSLAHLRNYMLFNSPRHRYALERGVHAYEELPSPPEFTAVRVTYGAASASFPWLRLTVLEAFGEVNGMTVPLPTLVLSRTGLDGNVDNECEELDSNSDSFNFLRTGTNERFEEGHVFCSGWVATPLRGNGNHTCAIGTSATLGRNPPNDLTPVPLELCTTRANLGRKAEEASVHQPERIVVTQYLSIGLPSPCQRDLDEGGLPHGCIPEQAALLQRFRDSVCTWSSIEASPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S374</accession>
    <name>A0A088S374_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cilia-and flagella-associated protein 96</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_090200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CFAP96 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN95936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704258.1">
        <property type="nucleotide sequence ID" value="XM_010705956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S374"/>
    <dbReference type="GeneID" id="22572590"/>
    <dbReference type="KEGG" id="lpan:LPMP_090200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090007000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_090200"/>
    <dbReference type="eggNOG" id="ENOG502RAQ7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="283553at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029358">
        <property type="entry name" value="CFAP96"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31144">
        <property type="entry name" value="UPF0602 PROTEIN C4ORF47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31144:SF1">
        <property type="entry name" value="UPF0602 PROTEIN C4ORF47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15239">
        <property type="entry name" value="CFAP96-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN95936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="306" mass="33435" checksum="8EEEE173342C8F56" modified="2014-11-26" version="1">MFSAPVYLCVGDEYDKRQGPTHKATGQQPFVVSAKRNPHITDATFDPFVSLSTGDPYRSVGFAGPFREGASTCGKMGQGSGAAAPPPFRPVGGSKKSSGKGDYYGTFSEKAPIRHETEFPPIKTAADYKAETAAAKRNFIVNPPKKGTYGYTGLTIAQAGEVQYVADPYEGNMRREALESKYETTRRMGSPFRSAVHASGCFDESKHGVSRVYSLTKPLPPKRSPSSQQATSGISAGRKPWVPGGALVPDLLKQPEYQEDPYDVKEQKVRAMRQKESAYKPWIPAGNDPYRHIYTKPIEYDPPAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3C5</accession>
    <name>A0A088S3C5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_355150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703446.1">
        <property type="nucleotide sequence ID" value="XM_010705144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3C5"/>
    <dbReference type="GeneID" id="22579543"/>
    <dbReference type="KEGG" id="lpan:LPMP_355150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350060000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_355150"/>
    <dbReference type="eggNOG" id="ENOG502SJGA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="262831at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="79"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO02646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="390" mass="44098" checksum="A91E980F9DCA7C72" modified="2014-11-26" version="1">MSALNDSRNTGRRSFLGGISQPQRLQGTPSSLFRDDVGASSGGGGDGTCEFEVGFDCLHSSRSEEEDAADVASSREKRLSRVQRDVRRHEVQIAALLSERHKHCEHLATVYEELEKVLHKLRLEPPQDLKQDAGSSSSPMFCALTNDEKDCTPLSTASTLASSLQQRFQQVLQRHQDRVYEVLIDYRQQIDRYESETSRRLRAIEDTVTQIQSDVRELQHRTSTQIEDLQHFQQNVQQRVEAVAAQQEVQRVTFDAAGESRDTKATKLMSKIQEDVARLRADTKVVRTKQIQSDKEFGEQIRSLLSAQHKAEQTLEVHSASIVQLRNQDSLEGAFHEVKDWLGDLEKRMVSRGELLQWTESLQSEIHQIRRVTSGALAHTVESVAPSQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3E5</accession>
    <name>A0A088S3E5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_355400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703471.1">
        <property type="nucleotide sequence ID" value="XM_010705169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3E5"/>
    <dbReference type="GeneID" id="22579568"/>
    <dbReference type="KEGG" id="lpan:LPMP_355400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350062800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_355400"/>
    <dbReference type="eggNOG" id="KOG0211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1695393at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032367">
        <property type="term" value="P:intracellular cholesterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040362">
        <property type="entry name" value="RELCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32059">
        <property type="entry name" value="RAB11-BINDING PROTEIN RELCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32059:SF0">
        <property type="entry name" value="RAB11-BINDING PROTEIN RELCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="121"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1052" mass="113405" checksum="CE5150E24FBF0CAD" modified="2014-11-26" version="1">MNPTGSSTALGERCELSEQEVLDWMSRRGFIQAYAALIAETSSPALAHDDFPTRQCFTCDGAAEVTTSGMVSTPTDVQAALRDSVMEALSAYRDLVGNSNVFAMLELWDPQLCSRYVQRSAERSEAELSRLEGLAQAVEEANVQLRTRERELDGQVKQIVAIIAERLQTLASSVDPMRKDILLPLLRTVAVLGSSGTVRAAARHMILTLYKRPMMEHRMAIVQEWLRVAQEASSRTLEQELIPELYTLVNAQVFERRLLALDCAAAVAPMLRRSPQVRYSLCQGLLRPLCEDDTSAVRRELPRCLSLLWGDATTNDTTTTMDPSASAGAVSRSTIEGGLPSDTSAVHSAVTRTSADRLSGASTVSLSLTQKTFFMELLVHLATDSSSRTVRQAAQTQLCEVLYPVFLRDGVLLTQFVPLLLTFIEMEARQQLLLKGPDKGNSNTAALGASNASAKAAAGGESQKGVSDESNTSAAAALSLSNIMTLAQLLHAALRCAAADVLHSREAEGRRDRCRASNDSQTLSSLSSAYVRVVLPIAYNLLCLLLSKVRFVSLTIGEEGGTLNGSDASTRLCGPLCALCATLASLVPLLDAQVWQDVVHYLKRSLASDPQDGVMATPVTESTSVVVAASSPSESLEPLSLQNAPDASLTEQDLVKGRLLFVFSFFLFLCGDAVTLPQGVTGASADGATAPETRETTGIDGSSLSTAPLLKPFTPKHIQSESLHFVAGSISLKSEDISCPRSASLVACVQCVAALAPFAMESHEVASGISGLANFLVASPEVRQRLTAVVLAHDTCAVLANERLKVALLIEPLMPLLKDLQPAVQDAALSGILSVSIALTEPRAQEKVIRPVLRVADASGCTSRFTRCLLQQFYQLMQRMPAEPREVLLYPHLSVLMDRLAELYVERVSQEGFAAAPAAAASSPTLSASVGARSTRYESTDAKQRDLGVHDWEETMLALQALLNSIVKCAVVTPTLVYRYLLPSIQQLSSDGILSGCSPAVRSRWLRLQKNYQIFMENNTNRLAPSGAVSTDGKPKVSTLLDRFKNELKRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3X2</accession>
    <name>A0A088S3X2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cilia- and flagella-associated protein 36</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Coiled-coil domain-containing protein 104</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_351430</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CFAP36 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703080.1">
        <property type="nucleotide sequence ID" value="XM_010704778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3X2"/>
    <dbReference type="GeneID" id="22579172"/>
    <dbReference type="KEGG" id="lpan:LPMP_351430"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350020100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_351430"/>
    <dbReference type="eggNOG" id="KOG4511">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272687at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097546">
        <property type="term" value="C:ciliary base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1520.10">
        <property type="entry name" value="ADP-ribosylation factor-like 2-binding protein, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023379">
        <property type="entry name" value="BART_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042541">
        <property type="entry name" value="BART_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038888">
        <property type="entry name" value="CFAP36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21532:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21532">
        <property type="entry name" value="PHOSPHODIESTERASE HL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11527">
        <property type="entry name" value="ARL2_Bind_BART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BART" evidence="11">
        <location>
            <begin position="4"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="410"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF11527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIO02280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="450" mass="48497" checksum="3B2FEC03715F1849" modified="2014-11-26" version="1">MTESRWITEALVQFSASPVWLTPIDNFLDGNCCIFRNESEMQLEYTIVHNKFKELVDSLLTSFLTELGVPMGAAVEALQSSLASSKETSDSRSERQAANKLLKQILNADNFSYFYTMMVKRNLELDILANAALCSQGVCVDGGAAPAAEMGDSETSAPAHVQRAIDANGGADEEDALRRAIEVSLQDSAAQEQLRAYHEACVQEDVNMQAAAIERQANSEKARLDTVLQAQAAQDLSNVEHYRQDHMDLIGKQKELQTEQFCNYSMAGRGPNVNGETELSKADFSSPKAPQAIPAPPATAAVTLVSTAAHLPVIASSSPPALPSVGPRQDALPAILSKATTSTSQPAISAPARQAHGTAFSATPVPTPAPTREELDKRAEYMREQREKILARNRASRQEQLNMFLQNNSSSTTTSFSAAGEAAGAEQSVTVEVARRLRGDLIGEGRKNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S499</accession>
    <name>A0A088S499_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cullin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_353130</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703250.1">
        <property type="nucleotide sequence ID" value="XM_010704948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S499"/>
    <dbReference type="GeneID" id="22579342"/>
    <dbReference type="KEGG" id="lpan:LPMP_353130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350038900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_353130"/>
    <dbReference type="eggNOG" id="KOG2166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cullin family profile" evidence="4">
        <location>
            <begin position="361"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO02450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="706" mass="79521" checksum="44DB4ACB9F3E98B7" modified="2014-11-26" version="1">MSSVVSSRKRMAEYSTFSDKWGIIEETVLCIFKKEVSRNSFQRIHHSVFQLCQAHYGSQVLERLEEQLYAQVSTVLNRIEDSSVYVADFLREWQDYNDSVSQISNVLLYFNKNYMYACHHSSIEHLGERIFCSSTLGNPEVSARLIASIKQSIHVPAAESIIRDIGQELYTAEGSKYFVRCMETPFVDAIVDKYAAQGEQQRQSLTTNNYLQWVQSVVSSESHKYADTFFYILLDKLTNALYSSLVLSDPSSVDDMLTGPTGLVHMLEEWDVTSISTVVQVFCAMKREKDVIDVIAQALKEKSEGIINDRSTGVFPFLGVQKMLQLIERAKELDGLFTAEEGHSQSPFLRVIRNVLGSDTRFMETLSVYYDSGIRQGKDDVVSTVGNNVLTILQLTPDLEAFEVAFRSHLAVRLIYAKPHAVDMECRFIDRLFNIYGSSVVNRFQKMVEDIRSATAAQEKLVADMKTKKISPPLEFDVLVLTSGLWPQYTNIPLSIPQSMESCKHVFQEYYRRRHNGRKIVFQMSLGSIAFQLCHGGRTYHVSAHTHFVNSIMALNSDEDVSVAVVARQGALSSDEVLTHFNTLCHVGLAERNGTEFRFNRRFYSSKSKVKVSAGVQKSAHDSSGGAIAACKGMDGARTMSLDATIVKLLKEHNSIDYHTLCCAIESELRGVCSPTRTDIKLRVDALMEKGLLMRGESANCYVYCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S4E6</accession>
    <name>A0A088S4E6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phytoene synthase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_353640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703300.1">
        <property type="nucleotide sequence ID" value="XM_010704998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S4E6"/>
    <dbReference type="GeneID" id="22579392"/>
    <dbReference type="KEGG" id="lpan:LPMP_353640"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350044400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_353640"/>
    <dbReference type="eggNOG" id="KOG4411">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270318at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000037">
        <property type="entry name" value="Phytoene synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO02500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="392" mass="45469" checksum="88C4E939AFF0DF97" modified="2014-11-26" version="1">MRNKEAADYYRALPQNELSKEDMWRRINKASADRAEATGPAIGSAEVDYIKLEDELRNFDLFHYRVGEIAYPDQVMRRDYYAMWNLAMSLNKARWSMLEVHSQRGMKTTGAGMKLIFWKESVGAIMEKRKMSEGQFTDSHPVLRPFAAAAERNPHMTKAFVRGFTDARLRVIQQPGNVQQLFDHFDKFYGYFFNSLLEVTHVKDEAAEHLMTHIGRATGLTNHCVMFWKKYARLGFTMLPADLCADNHVNLGLLKNIPLASRDRAVRKVLFDVMCIVKDEMLHAQKVAKDVLPKAWPIVMECFYANYYLGFLQRRDFDVSALFADHNIENAGFVWYRLKKRWEWERYQSIERLVDESAPLPYINTSFAHRGSQYKMASGVGSGTPQTQRTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S538</accession>
    <name>A0A088S538_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Threonine synthase, putative</fullName>
            <ecNumber evidence="6">4.2.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_140350</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="6"/>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697269.1">
        <property type="nucleotide sequence ID" value="XM_010698967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S538"/>
    <dbReference type="GeneID" id="22573302"/>
    <dbReference type="KEGG" id="lpan:LPMP_140350"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140008600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_140350"/>
    <dbReference type="eggNOG" id="KOG2616">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5203861at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1380.10:FF:000005">
        <property type="entry name" value="Putative threonine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000075">
        <property type="entry name" value="Threonine synthase ThrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1380.10">
        <property type="entry name" value="Threonine synthase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029144">
        <property type="entry name" value="Thr_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037158">
        <property type="entry name" value="Thr_synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43515">
        <property type="entry name" value="THREONINE SYNTHASE-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43515:SF1">
        <property type="entry name" value="THREONINE SYNTHASE-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14821">
        <property type="entry name" value="Thr_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Threonine synthase N-terminal" evidence="5">
        <location>
            <begin position="103"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN96616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="676" mass="73993" checksum="49202C97455804DE" modified="2014-11-26" version="1">MFTLVLIGRSSNELKAQVRVALVDNAQLFSVAGSAEGESDNVFVLCIDTEDSAIMEPLYQGYHYRFVWSEQSSMAELVSAVHHRLDSMAPAQAHKDKRISGSFTSTRGAAEESNFLTVVRDGLASDGGLYILKQIPTMPDSQLYYFCKQRNLAYVEAAVIILEQLVDASILPSTLYPLVLQAYDRSRWSDKDDICPVTPLLRNEATAPTRTDGAGAVDTLSRSASFNAPERWATNMSVMELFHGPTAAFKDFALQLFPRYFGRATLTEAKEKYVVLAATSGDTGVAAISGFVNAGGHSQVMVLYPMHGVSPVQQTQMLSFDDGTQVRAYAVDSNFDFCQRTVKVLLSNDALRNKLAVAEPTAVRLSSANSINWGRLIPQVVYYFWAYRHHVQHPPAGWVFGDPIDVVVPCGNFGNILSGYIAKLMGLPVRRFVVASNQNDVLYDFVKTGIYDVRNRTLVVTSSPSIDILKASNVERFLYLLSNGNTALVGQLMHDLDTAGIFTLPNDMRATMQAVFTAGRCSEEDCAATIKRVFELSGGSRLLDPHTAVAVFVAQEFREEELLSRDLTYPTSTDTDTDVPPLVIASTAHWAKFPAPVLHSLRDEGAQLGEPAPSVSAAIQEVRALYTEVKKAAPKQQVHPALSHALDVAEKMGKEARAVRADVAAIQKEVEGFALC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S7A0</accession>
    <name>A0A088S7A0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_191090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698104.1">
        <property type="nucleotide sequence ID" value="XM_010699802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S7A0"/>
    <dbReference type="GeneID" id="22574163"/>
    <dbReference type="KEGG" id="lpan:LPMP_191090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190018200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_191090"/>
    <dbReference type="eggNOG" id="ENOG502RZWB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271017at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="378" mass="42060" checksum="7EDC7C848E409CDA" modified="2014-11-26" version="1">MLKQSIRAAARKGGAGALTSAPEAEQQSCSNALLPYALRRAAACEMLYGGVRVQYLVQPPFVLHKIRSENLPPPSLSAERHDLGLEMQLPRDLHGYKNINMAIQRQVGADASTLDGEQQQQQLQDGHGDGFDMGAFFTEQHHPERHHNSSLPYTKYDTNNVLAMRLFPVNIGIRARTEAIRIRTEDCLQRLRDADICAKMHMPLEYPLPLSRRSQYAAVYRATREGRYDTPAEEADDASRTAHLRGAAAHPPPSELSIFTRPVDRLGSRSGSTTVCTLHADHTSFPVHPFAAAALASGHGARSSSSAPLSSQRWLPLQMLKPMGHSWSAAMRSSGVRGPHMQLMQERLDQKGFGWKRKSRSLWQQDVATAGFRPHRYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S7H3</accession>
    <name>A0A088S7H3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_200390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698238.1">
        <property type="nucleotide sequence ID" value="XM_010699936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S7H3"/>
    <dbReference type="GeneID" id="22574246"/>
    <dbReference type="KEGG" id="lpan:LPMP_200390"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200007700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_200390"/>
    <dbReference type="eggNOG" id="ENOG502SKMQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271148at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839329" evidence="1">
        <location>
            <begin position="28"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="560" mass="60682" checksum="96931F58B97DDE89" modified="2014-11-26" version="1">MRQSPSWPVRLPLPPVMLLILLTYAWTLPRAFSMHAVDHDAGADVHSTGSPLAASAAAEEHVTVFMCAGSGDLSGVHELSGLITAMEGTQVLSLKYCQAAHLGYILHADGHAVRSLAVTTGLNYISSTLCTRSVLRLRRQRGYTYDAMVYIGTSGFSPMVGGWDPTNTSSYAAFKASEEEATLKGEATTSSVDTASPAPLFKTLEQVREELAEEARLRQAAEDGGQLFTLPTSSHLNFEDARTGEQMDLDGCSPRVPSAITPLSLGSVCVTSTAYLIETGSCTEHVRHTQCSRPHCSSLRSELASEAKIYFASDALARKIKAASHGKTWPEMPEMVKKGQLRFWSTNEAVQPVGEGEESHRVAPSHPSFVTCAEATSNAINTGAEREYLCREHTAHALGIAQNHLSKRDHSEAAPQGSPLTTQNVACVRAMESMGFLRTLADDITARDIPVAVVRSASNYVMYPMKKMYVPPAVWRSALDAGQLTVSPRVAAMLKLEEAAAADGEEALRESAIAAYTWHQNPYFMPEADYQSFLNASLRYAVDTVTFVLSNYFFGGRSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S7W3</accession>
    <name>A0A088S7W3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2CD3 N-terminal C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_201520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698353.1">
        <property type="nucleotide sequence ID" value="XM_010700051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S7W3"/>
    <dbReference type="GeneID" id="22574361"/>
    <dbReference type="KEGG" id="lpan:LPMP_201520"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200020400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201520"/>
    <dbReference type="eggNOG" id="ENOG502RYCQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="242958at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057537">
        <property type="entry name" value="C2_C2CD3_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25339">
        <property type="entry name" value="C2_C2CD3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2CD3 N-terminal C2" evidence="2">
        <location>
            <begin position="7"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="994" mass="108433" checksum="B4EC20332419E41A" modified="2014-11-26" version="1">MRVLYGTPLPPGLVAPTRGELRLRVDQLILDNETVNHNPLVQLFEAPDSASAVVAAEVDRPEATSASFSRSPNRFVVPVDYCCVGPIFWGETRPSAQGQPATPQLRRGPLTMAYPIKMVATQFEAYLERMTASPQQGVQVDVFVPSSYSGRPPVTVGRCRIALETLQPGHPVKGWFPVMHRRFRSSAEEVAPYTFAEVPVGKVKLTVTVEYFLSSRRPSPEPTVSTKHKRRESKDGGRVPLPHAKTRRSHHHLGRTGKDAAHAPTRTSSTSTETAAPDSSVSSLPTPVANERVRQRGLHRRQVDHQKTALLQDKSSATQHLLQKGLRLRAQMEAATRGLSFDDVDATAEAVPLGDRRVVHGHVSFKDVGDGMFADDMDEDVNDGSAAAYTSEDSDEEKFALQMQKDAEARDRRSVRQLNSTMSSSSHLAPAAAAHHLVRSPAAEPAPETAVEVLPNTNGDRVHSTRAAVELWFSNFSFAHTALTVDLRKIRINVRLSSDITTLEPSSGPLSSFVHPVPMQQPSICLHFDVCSFFEDRSKLVVEAYKVVGELELENENDPWSIEGPRHVAREELLGLSVIGLYRQSRAVVFRDPVADTSNVFAHLEVRVQHHSISHSTTTSTVLDALHQQQPQRQLSWNPTQGAASSSSQTPVSDAVQLSSIPASAVVVRPAKDHAVGAAVQTSPARRSHVPDALLREAASASPGIYPSRVLQAPVGGHSLSSDVTGRRRLRIVVYSAVELPRVAVAQSHNHSSATGCGESHFPIISARPPSIPEAGVDGATSYAEPNSFVTVEEVYRVEEAWGTKSKTAASTSCDPSAPSSCRQSIHNWYVDEAHGGFYDRSAVAKESSNPDYNYEVILQLPEITVPMDSSISAAAMTHGLADMLDELQLRVWHSDLSRQASVLSDSAAASGCAGDRSGRSRRASARQQEEHFWECAAYMGTCRVDLRPLRYLNRLDGYYRVVCERTPESAVGPSATEVESNTIGYVRLSVSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SAZ7</accession>
    <name>A0A088SAZ7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_241890</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699528.1">
        <property type="nucleotide sequence ID" value="XM_010701226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SAZ7"/>
    <dbReference type="GeneID" id="22575598"/>
    <dbReference type="KEGG" id="lpan:LPMP_241890"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240026200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_241890"/>
    <dbReference type="eggNOG" id="KOG0723">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="240298at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000154">
        <property type="entry name" value="Hypothetical_protein_-_conserved"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763:SF28">
        <property type="entry name" value="GEO10507P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN98821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="121" mass="13508" checksum="31764005359278E8" modified="2014-11-26" version="1">MALPIAAGILAGCGFYYISRVAPRIAQRVSASGAQSAPSRFLNSAKQYHKFECGFQSPMTEYEAYLLLGFKESEADAIFHRPPPEEVKKRYRNMMKVFHSDASGTPYIATKLNEAKDLLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SB99</accession>
    <name>A0A088SB99_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_250720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699643.1">
        <property type="nucleotide sequence ID" value="XM_010701341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SB99"/>
    <dbReference type="GeneID" id="22575720"/>
    <dbReference type="KEGG" id="lpan:LPMP_250720"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250012800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_250720"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="388" mass="43342" checksum="994A75589F0EBFB2" modified="2014-11-26" version="1">MAKHIQRMRMELRATRRRMWIRCPTRYPATYDCEISINEFDRAVRCPPCHSATTQPVAAVSAISTLPVPSRHPVDGAERSLELKASTSQVCTLLNVRHGESTSTAHQLKPQQSRHHNGLLCRHYVLDSIVFLSLFTHICCIEYWSNLRSCGVNVQGLEQCHLEIPEDIFVVVPGGSTADTREVRKTDEGPPPMGFPCPSTWLFDFEGSTSFHYLLFIDVVCGLQEQSGFVKHTSVLLLHGTQGVLVLPTHTVAITTKLCQCTKDAANKVYLDLLRDARHNLDGTHIIHPFLRDIIILPHLRRQRALRGELDATLRHSVELQQQQKKHTDPSGGASISVSAGGTIGRGERLSPTSTTQRTTESIDKDSDDRKPNEAHTWWKSGASAPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SCT3</accession>
    <name>A0A088SCT3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S acidic ribosomal protein P0</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_271410</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Ribosomal protein P0 is the functional equivalent of E.coli protein L10.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">P0 forms a pentameric complex by interaction with dimers of P1 and P2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700228.1">
        <property type="nucleotide sequence ID" value="XM_010701926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SCT3"/>
    <dbReference type="GeneID" id="22576319"/>
    <dbReference type="KEGG" id="lpan:LPMP_271410"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270021100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_271410"/>
    <dbReference type="eggNOG" id="KOG0815">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="246752at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05795">
        <property type="entry name" value="Ribosomal_P0_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1730:FF:000005">
        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050323">
        <property type="entry name" value="Ribosomal_protein_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030670">
        <property type="entry name" value="uL10_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039087">
        <property type="entry name" value="L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 10" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="9">
        <location>
            <begin position="118"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR039087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN99521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="323" mass="34448" checksum="72B5602498C20434" modified="2014-11-26" version="1">MPSITIAKREYEEHLVDCLTKYSCVLFVGMDNVRSQQVHDVRRALRGKAEFVMGKKTLQAKIVEKHAQAKNASPGAKHFSEQCEEHNLLSGNTGLIFTNDNVQEIKAVLDSHRVKAPARVGAIAPCDVVVPAGSTGMEPTQTSFFQALNIATKIAKGMVEIVTEKKVLSTGDKVDNSTATLLQKLNISPFYYQVDVLSVWDRGVLFTREDLGMTEDIVEKMLMEGLSNVAAISLGAGIPTSATIGPMLVDAFKSLLAVSVATSYVFEEHHGKELREAALSGSLVGAGSAAAESAAAAPAASSAAAKVESEESEEDDFGMGALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SG46</accession>
    <name>A0A088SG46_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_311910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701582.1">
        <property type="nucleotide sequence ID" value="XM_010703280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SG46"/>
    <dbReference type="GeneID" id="22577617"/>
    <dbReference type="KEGG" id="lpan:LPMP_311910"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000028800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310026000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_311910"/>
    <dbReference type="eggNOG" id="ENOG502S1SI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="29879at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF93">
        <property type="entry name" value="CORA-LIKE MG2+ TRANSPORTER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="496"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="745"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="784"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="645"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="815" mass="87142" checksum="E96A331B0DE5B0CF" modified="2014-11-26" version="1">MSAAIHIPPTRRSNPVFSQRHHHPNQPSPPISESMVRERLSANLPDSFNYLSNTRAVGRSHRPHSSSSSGAGSDRSATPPARTVRSGPGNERRSRPPHTFTRGSSSSSSCSSRSSSTSSDGGERYSFYARLAKIHRGGEPAALARCCDTVRGTLQLLKQAQLCTGDSDGAAGFFWLDLHGVPPPPRRGRAALRDADSGDAPMSALWRALGLQASTVHTFTTVCEQRQAHPRPARTLLDDVYEEVVVDFSCPDDRVLQVGPLRAPASAEPAMGVCDTGRCPEECVQLMHEQDSTAKRTPRDGVAGSAHYVALELATLLTPVHASAATMREAAWETALSPAPSAEEHANEPLNNLVWAGSLGRSMLSLPAAAAAIGRPAPPVLPAGLCQATQPSPHSQEPPAAAPLITSTYVVCFPAGCVTWCPASTLGLTSTDCRAHRSAAAAEVQCVKSWEQLQTAVLRRMWHATHLSRGAAAFPPHARCGAAPGELSAPSMSVALTEPVMCTSIFVSLLLSSACYAYLPNTAKFLGEVDAIDSMLPLIEMNCESDQADALRRVLLLRRRLALHRRLLFQKICLLEALDRPAIHTAAGFIRSLKSPMWVPCSATPVRIAERCKSAGWGSASAGGDRSNHLNASCTDVPWCSGAGTPTGNVARSRHSSEGLDANDSNGRPSPDKSSSDHVAQRVTWAAPSLQHQMAAAPSLNAIHKGITSVLHNLEVARTVLGNTTLIYTSKVNFSNSRTSETADYFSLICQYVLIVVLPLNIVASHWGMNCPVPFMAVEGTTPFWGIVGVLAFIGVTGLIFPFYAYKTRRIYLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SG78</accession>
    <name>A0A088SG78_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipase, putative</fullName>
            <ecNumber evidence="2">3.1.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_312300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.3" evidence="2"/>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701617.1">
        <property type="nucleotide sequence ID" value="XM_010703315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SG78"/>
    <dbReference type="GeneID" id="22577656"/>
    <dbReference type="KEGG" id="lpan:LPMP_312300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310030300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_312300"/>
    <dbReference type="eggNOG" id="KOG4569">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="345705at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051218">
        <property type="entry name" value="Sec_MonoDiacylglyc_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856:SF25">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="1">
        <location>
            <begin position="122"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="373" mass="41937" checksum="2DF34885ACBF8B2C" modified="2014-11-26" version="1">MPMAITLERRMPQLHSCASLCVTTLLVSLMMLLAFPLFTSLTKKSESIIANTASLDYNVTEGRKALYFCKSAYCPVKSVIEWNCGSACSNATPNFRVFNVYDNTSTGNFGYSGIDNDAGRIVVVFRGTHNTANWIQDLDFWSIPYPNPSCGNNCRIHRGFYRAYSSIRYQLIYDVLSMLERYPSYTLFITGHSLGGAMALLAAIDFTTWNVSKPEVVDNSVQPSSAAPKPSHLAPVMLYTFGEPRVGNQYFTNWSTSVLANEKQFRITHAKDPVPHLPPLSWSYVHVPQEVWYPADDEAVLLCQDNSSTEDPLCSNSVYATRVADHLIYFGICTRCECTAAEMEEIYKYKLPPETYSLLALDYVMNKPRPTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SJK4</accession>
    <name>A0A088SJK4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nucleoside diphosphate kinase, putative</fullName>
            <ecNumber evidence="8">2.7.4.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_343740</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="8"/>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702797.1">
        <property type="nucleotide sequence ID" value="XM_010704495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SJK4"/>
    <dbReference type="GeneID" id="22578879"/>
    <dbReference type="KEGG" id="lpan:LPMP_343740"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340044900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_343740"/>
    <dbReference type="eggNOG" id="KOG0888">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270127at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005879">
        <property type="term" value="C:axonemal microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04412">
        <property type="entry name" value="NDPk7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.170:FF:000005">
        <property type="entry name" value="Nucleoside diphosphate kinase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000004">
        <property type="entry name" value="Nucleoside diphosphate kinase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006602">
        <property type="entry name" value="DM10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057579">
        <property type="entry name" value="DM10_NDK7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037993">
        <property type="entry name" value="NDPk7B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43109">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43109:SF1">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25364">
        <property type="entry name" value="PH_NDK7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00676">
        <property type="entry name" value="DM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51336">
        <property type="entry name" value="DM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DM10" evidence="7">
        <location>
            <begin position="3"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO01997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="337" mass="37280" checksum="22E4177D540436B4" modified="2014-11-26" version="1">MVGEQRDTFVVEYFDPQANLSRTYQLCYFADDKTIEMYDLKTKRLFLKRCAYPSLSPNELYVGATINVFSRPLRIVDYGDDVTRKRLTTNSGECMITVDMENYSALAGSVVEAMTTQGLRITFIRLVELSQSLAARVVSKTQRCLLLLVSGAGAREKVASVAASFSSAVTQILSESAMQELRETLMGAGESTATLKNCAVCVIKPHAITSGHQGPILSRLVEEGFYISALGSYQLTVADAEDFLEVYNGVLPEYKKLVEQISSGPCWAIEVCAENAVPALRAVCGPHDPEVCHVLFPHTLRSKYGVDRIRNAVHCTDLEEDGPLESEFFFSLLQNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4Y0</accession>
    <name>A0AC62A4Y0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3420500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="XUY36814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="748" mass="80580" checksum="79B6C1CB8887A0D6" modified="2026-01-28" version="1">MSHYIEACRDDERFTARLEEATKEMGGLLLKTSRTRHELDRMAAEVRMRGPLHFYPCNIADCVDLAPSTFAGERLAPPQVRDDLARNMLSAELAQWARWHLPSLVAPLIEAQVQQRLLSLRDSVDELRVRQAKVEKAAKDATERVHVHRADIHADFAASQEEMQRDLEEHQRGVKRQIAAWSEELRHVREDVLALGQQRVSASDRQEQRISGALQRQQTHVQETLEALEHGLQRWRRAMSRAVQKETQELHAQHRVLENRVAQAQGMLTSTADMAARCTAETRRLMEDAMCRSSEVRVCRRDVNRLEMLVQCSSLQTALLTGGAGSSDSNDSSTAPAAASVVLNGLTQEMARFSDSLHAMVHRVDGLDRHVRQLEMAVARSTAVSCGQGTYHSSMRGVDEESSYGRSFASTSRPSCSYLSKATGLRGRCASAGEARAPSPLAQNDSSDVAPIHNGGAAAKPRTTSITLVSATQPVGMGSALGGGHYRTAGPEVQLTLTPLMSASPSSTTYHLPASHLSGSSLRFEDEAGDSHSTPVIVSDARPAPDVEGDRVLLRSAAAGTGVQQPLERRATAHATPAKTVEGDTQLGGVAKPTAAKTVAHGMPLPLAAVDASQIARQDVAPSLTHQYDASSWPAASALSAGNADVTYLVKRPSSCLATCEAVAVAEDVALKRQSGSDHAERPVVATPCSPVDSYLSDTPAADLYNSKANVASAPKSSTPEIAQYTPAQASDSESERDNHVIARSALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A567</accession>
    <name>A0AC62A567_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histone H2A, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2920030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="XUY36938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="131" mass="13890" checksum="7392336FA5BD1A4F" modified="2026-01-28" version="1">MATPRSAKKASRKSGSRPAKAGLIFPVGRIGQILRRGQYARRIGAAGAVYMAAVVEYLTAELLELSVKAATQSSKKPHRLNPRTLMMAVRHDEDLGALLKSVTLARSGVVPSINKVIAKKGGKKSKATPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5A5</accession>
    <name>A0AC62A5A5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histone H3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1620260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="XUY37037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="66" mass="7238" checksum="D87F239EB5F19D1A" modified="2026-01-28" version="1">MPCARCRACRRRGGPALPEQRDPGDPGGVRCVADGCHEPGQHPREACVTVRPKDVQLAVRLRGERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5C7</accession>
    <name>A0AC62A5C7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha tubulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1320130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="XUY36984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="451" mass="49683" checksum="3D47FCCC1FBC5BF5" modified="2026-01-28" version="1">MREAICIHIGQAGCQVGNACWELFCLEHGIQPDGSMPSDKCIGVEDDAFNTFFSETGAGKHVPRSLFLDLEPTVVDEVRTGTYRQLFNPEQLVSGKEDAANNYARGHYTIGKEIVDLALDRIRKLADNCTGLQGFMVFHAVGGGTGSGLGALLLERLSVDYGKKSKLGYTVYPSPQVSTAVVEPYNCVLSTHSLLEHTDVATMLDNEAIYDLTRRSLDIERPSYTNVNRLIGQVVSSLTASLRFDGALNVDLTEFQTNLVPYPRIHFVLTSYAPVVSAEKAYHEQLSVADITNSVFEPAGMLTKCDPRHGKYMSCCLMYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKCGINYQPPTVVPGGDLAKVQRAVCMIANSTAIAEVFARIDHKFDLMYSKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGAESADDAGEEDVEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5E8</accession>
    <name>A0AC62A5E8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histone H3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1620080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="XUY37019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="66" mass="7238" checksum="D87F239EB5F19D1A" modified="2026-01-28" version="1">MPCARCRACRRRGGPALPEQRDPGDPGGVRCVADGCHEPGQHPREACVTVRPKDVQLAVRLRGERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A653</accession>
    <name>A0AC62A653_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amastin-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0820070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="XUY37287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="187" mass="21250" checksum="68964CA9A4383FB9" modified="2026-01-28" version="1">MEFTLVFLLYAVVQFIAFLFVLVATPLDMLYDKNGSRFDNRPCVTLWGTKDECYGLTYEMTSDEVWNVCPVRRNRFRAAQAFAIISIFVYGLAAVLGFILLWCCSHLRFVCLALNVTGIVTVGFVWASILVTYYKTEFPCLRENLYTVLGSGFVLLVMAWCLDIINIVLLLLPWQAAHPSESGETKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A661</accession>
    <name>A0AC62A661_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amastin-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0820030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="XUY37283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="187" mass="21250" checksum="68964CA9A4383FB9" modified="2026-01-28" version="1">MEFTLVFLLYAVVQFIAFLFVLVATPLDMLYDKNGSRFDNRPCVTLWGTKDECYGLTYEMTSDEVWNVCPVRRNRFRAAQAFAIISIFVYGLAAVLGFILLWCCSHLRFVCLALNVTGIVTVGFVWASILVTYYKTEFPCLRENLYTVLGSGFVLLVMAWCLDIINIVLLLLPWQAAHPSESGETKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6K0</accession>
    <name>A0AC62A6K0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0820360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="XUY37316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="580" mass="64069" checksum="43E5352DA66440E0" modified="2026-01-28" version="1">MAKSKKGGRRGTVVKNLWDLSDLQAAAPGGSRGSGTHERPSAATTVATYRCPRPVRHVDPAALKRAFMLQNFQFILRSELLTITSTQGLPQGQRRLLECIQLSDSLVPWEVVHSVVMRATPEEYQCPICMEVPTAPRITECGHVYCLPCILQYMSRQKAAGAPRKCPMCHDLLTPYTLRPCVLQPVQPRRVGVQARFDLFKRHRNSCVLRRSEDPFFSSPPPSSEKGVAIHLPAYMEPFSYQSRYVMATPQYEAEQRYADCAGISERLRELGQPLNESDAEVGQFLLEALGEVSKEPKGLPPSMLRNSPPLAPRPATTPEGEDGYLELYADGEGQPYYLHMLTVKMLKHDARLRNAPLPNTVTGTVEEVVTMKQTEETRRIYKVFSHVPLHGMIKLCVVNVDRLVLPETRAAFAAALQKMASDRAQRRHRDDRAAGEDASWKQYLMKYSSRSGIGRGDCWGFSPDTAPSDFSIDTESLPYLKLPSTGSGGSDHGLPPNPLDTRQRATKRQDMQSLLVDTVGAPPPRGDSAAAAFRSLTTNTPSTIAAGCWAQGGAAKLFAKAERKEPTISTWGGHAFTPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RII3</accession>
    <name>A0A088RII3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_070970</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP009376">
        <property type="protein sequence ID" value="AIN95782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704104.1">
        <property type="nucleotide sequence ID" value="XM_010705802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RII3"/>
    <dbReference type="GeneID" id="22572432"/>
    <dbReference type="KEGG" id="lpan:LPMP_070970"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_070014900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_070970"/>
    <dbReference type="eggNOG" id="KOG0583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000279">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000096">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF32">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="10"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN95782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="297" mass="33639" checksum="596C5F1C88C25589" modified="2014-11-26" version="1">MGAPKRLGKYELGRTLGTGNFSKVKIARDTETGKEWAIKVIDKEQLVRERMEEQLKREIAVMKMLRQPNIIELHEVMQTSHHIYLVLELVTGGELFEKIATAKRFDESTARHYFHQLICGINYCHRQGIAHRDLKPENLLLDANDTLKISDFGLSNLQRTSTSGGGTMLQTVCGTPNYVAPEVLKEQGYDGLKADIWSCGVVLFVMMAGYLPFDDENVNALFTKIERGEFRMARHFSAEARDLISRMLTVDPHERISLDGVIAHPWFSVDWNPAMLTQGESNSSPNTTQINNAIRNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJB8</accession>
    <name>A0A088RJB8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_090870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN96003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704325.1">
        <property type="nucleotide sequence ID" value="XM_010706023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJB8"/>
    <dbReference type="GeneID" id="22572657"/>
    <dbReference type="KEGG" id="lpan:LPMP_090870"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000051600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_090870"/>
    <dbReference type="eggNOG" id="ENOG502SIWW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273680at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="524" mass="57726" checksum="D9F2260F0D222AE1" modified="2014-11-26" version="1">MYSFSLASNCKSPISDSTGLAPPAVAHRIRAPCELALHQRLPQQSNGANDNKDVVQVSNARFGWHPAHQHVPTSSLYTVDPPTEQPVRVHNLNSYMGLRDAADWSVEVQREREEKKRRALAQHEAAKLEEQRRRDAQEEEAKEEMRQRRLERLQKRAELREADSMADFQDRNTQFLQNQLWLIHLGNRVRQADAQHKAHARETLYKNSSNGSNSDVHHTSMSNGAGTRVRGQHATTQSTEISLRQAAQVTEEMYVRLSLAYRNEAHRSRAAAEILDPGELNVKRLSRPQAESSVGAFTLPTSALPQSQAATATSTPSHSPTASPAPATGMATAAAEPVPFRTAPPMFTHTSAENMGQYANAIPCTYIPEYFDPPSAAAVTSGKATAPPHAGEPRQHQQQRDIVMPLPLSPAPVSRDVSGTLQARHYPWALYSAAAVRESMLPAAPPREASLPVHQWGAAELRDSMFGHCVLPDGTMQDQCERKKLCAAHLSYTTLPHDNATATSNAAVASPVPLHFGKRMETWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJI7</accession>
    <name>A0A088RJI7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FCP1 homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_030840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009372">
        <property type="protein sequence ID" value="AIN95319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701027.1">
        <property type="nucleotide sequence ID" value="XM_010702725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJI7"/>
    <dbReference type="GeneID" id="22571950"/>
    <dbReference type="KEGG" id="lpan:LPMP_030840"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_030013100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_030840"/>
    <dbReference type="eggNOG" id="KOG1605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000286">
        <property type="entry name" value="NLI_interacting_factor-like_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="318"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="612"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="738" mass="77764" checksum="19456F491EA40B00" modified="2014-11-26" version="1">MLADIVKYARWLWDAVLLPYVITSISSLASDGWESVTHLKESVVVLLYFLCGCSHRTFPLSRSAVEAQRSATAVAAAAGASKASVAKSATTTPRMTQRSYNSVSEGEENDTDSEADVKQGQQANLSMGATAATGEPTASERCVDEGDGDGVDDGPPLIQRRLLFGKKGEVEGWMSAVRSRLLVPPHHPLFTSRSLHQLVSIVVGPIQQPTVSTMPTRHPEPQWPPHFLCASNSGCGGGIGSRSVQGDPSTDDNSSSNSSITPQTLRQRTNAAAAAPRCRQASSVVYKRVSSRNLDFSSSGVPPHLIASITAHHVLSYPATRQKVLVMDLDETLCHVSTTTANMEGPPTFSEVIPTASGAELFHVWERPYTRLFLSTAAKLFNLVLFTSASKPYADTILQRIDPDHLLKYRYYRQDCRLVPRGLLRKMCAAAGIRGLPLAAGGGGNSGGVTRGSSDRCRGGGGGNSSARPAGSLSSAGGMDNRRSVSTTNSDNDVNRSGGDCGGSTRGGGNTLPSEAEGSLRGSGGTAIHDHTLTASPFVGPSPNRGGVDTGLPAIEKAAMNEHTKVPVKDLRLLKVPPELLVMIDNSEECTLVNPENALVVSPYIPALSKIAPPAREMTRRRGTRGRDERSVGGGAAAVQPQSKLKTSDDAAGDTSEGGIATDASSNINDGGAGRLQAADDDDVAGGTSDDSIMGDDIPTNDVPEDDEDEVLLALLSLLECLLVVPDVRSILRHGKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJP9</accession>
    <name>A0A088RJP9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_091150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN96030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704352.1">
        <property type="nucleotide sequence ID" value="XM_010706050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJP9"/>
    <dbReference type="GeneID" id="22572685"/>
    <dbReference type="KEGG" id="lpan:LPMP_091150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090017000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_091150"/>
    <dbReference type="eggNOG" id="ENOG502QWKK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277272at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="282" mass="32821" checksum="A81A00AF4C9E01A2" modified="2014-11-26" version="1">MPPLHSRATRQLVKERNKVEGPRSLHRGIHYQENEAHALSYMQNTRKKRADHRDLLVHHQRINEDLQDIYARTAALHSGDMTMEERIEENWKQFERIGGKRPVNVRTRTQDTVLCANQSSVPYAERLAQVSQQKKELRERGAWERLTHGEAVDYSQGSALHAAKDKRVQMFQRRQLRRAHLLRRVGDPTPLKQSGTYDMNSGTLQVFNKTIRNVQREVAHDARIAEVRKRRKGSRSQWDLNEGGNVNRPDQDVLRYSRDGELGPRRKAGGGRRGHKRGREEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RK69</accession>
    <name>A0A088RK69_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA polymerase alpha- binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_120900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009381">
        <property type="protein sequence ID" value="AIN96417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697070.1">
        <property type="nucleotide sequence ID" value="XM_010698768.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22573096"/>
    <dbReference type="KEGG" id="lpan:LPMP_120900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_120013900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_120900"/>
    <dbReference type="eggNOG" id="KOG1274">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="427368at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022100">
        <property type="entry name" value="WDHD1/CFT4_beta-prop_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048591">
        <property type="entry name" value="WDHD1/CFT4_hel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932:SF10">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20946">
        <property type="entry name" value="Ctf4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12341">
        <property type="entry name" value="Mcl1_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDHD1/CFT4 second beta-propeller" evidence="6">
        <location>
            <begin position="585"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1/CFT4 helical bundle" evidence="7">
        <location>
            <begin position="902"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="363"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="488"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1022"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1153"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1226"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1285"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1382"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="380"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="432"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="488"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="506"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="560"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1028"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1050"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1181"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1263"/>
            <end position="1273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN96417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1403" mass="149746" checksum="08CADDC6B261D41D" modified="2014-11-26" version="1">MLALRDAHARGATRVSIGGQHLLTGGADGVVSLYSTKQWPKGAALWSFRCHDGAVTDVILADTLELALSCGRDGRILLHESILDNAELVSRVICQVTGEVRCLDMDVERRRLYIAGDSLRCLDMSQDKFQIRTIPLVVPFPLVSLAVSPCGRYIAMASASGELGVVRPHATTPAEASTAPTVSFVFRSVLSPAAQKEDTAMYRMSWCGTTAGGLMLMVPTFTEVRVYVLEDGQSDGSLSAPRLRAVGGLHDGDFTDLHGALAYRITKTQVACLLVTRDGLFIGKAHIKTLAMSRHTSERYNTLSPSTPGSELTMLVATGVEAQGSAAAVTDVQVNPASGDVVVGLADGRVSLLRRASPKAWNAATSVDSSAAANEGGTDEGAKSAAEEDDKAKVANRKLRQDRRADKKSVYAGPAKGGDHGFIDDGSDDGTLSESSVDSTSTASSVSGVVSEDFGKVVSDLQRNGASLHGNDGERPSRWRDDERAALAHANREAERQRGRSRFLDDEAEEGTSSDDGDEIGDGTAVRVRGQARAAYDEEGPYSHDDDVSMAGHGEDNGDFANTSSSRAGGSTLPLSRGLAVQDYSFQIGATPAGEEGTCYLAYNSVGYIHCSREVTTVHFHDISHPAVRVQLRDTIVMGALSPVGAAFIVVPADPTEAQGSVDEAPRLSVFYHAFMPLGAQSEWRVVLLPGETVRCMTAGIRYVAVATSHYLRIFSLSGLELAVLSKCQRIVTMVGTSSRKLMNSFKADFDPLAIIALTGTGELQMEVIDVGARTSALPPRTVPLTELPDGSTHQLQWLGWSEDGLLHVVDTAGVVRMFTEDWGGSWVPVYDPRTLVDQSYALWVYGISENALLAYRYSRDDPSYPAAAASGLSTELVPLFLPLTRTMSEDGLERWDKLLRQQLRCDELKRHSTFYNTSIAKYDEVHDHHLLQFFDSALKSQQTTRAMELAMLMEIHDRVVKCAQLANTNGHVKLVPKLLALYDMRMATKQRRKCALPAKETLVSERKKDELLHRLLGQGLPQDTKAKTTSGAAAAAPTPVSIEVEDDESKEKKTESRTSPLRERASPTASNLSATSPSAMSTATTMMTADSKALPIQARRHISFAKEVALSPPASQSSLDTPTSALLATRSSAPAPSRKVVNPFAKPLVKSANAADEVRHASLTRPQQPHHQHQSHLQVATPSTATHSSTAPATEGDTLVGSSYLHTPPRINAVATRTSTVAVAPENDAAMDVSPVDSTSPRSRVSAGHIASSPSHEARLSPSVSAGGSATTPSLSATIHKSDVHRPATPAPSTGFVARELPNTSGASRASRGAVDPFLEESPPVFACASDSGCLMGANSSATAAVAEMQVSIQSLLDAGHNETAPVVRSDGFGEALRKRYREDEDEEAEGAPIPVLPKLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKA7</accession>
    <name>A0A088RKA7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_120350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009381">
        <property type="protein sequence ID" value="AIN96363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697016.1">
        <property type="nucleotide sequence ID" value="XM_010698714.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22573041"/>
    <dbReference type="KEGG" id="lpan:LPMP_120350"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_120008300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_120350"/>
    <dbReference type="eggNOG" id="ENOG502SIVE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267941at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="711"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="766"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="889"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1076"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1207"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1397"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1474"/>
            <end position="1494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1508"/>
            <end position="1553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1757"/>
            <end position="1786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1800"/>
            <end position="1908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1959"/>
            <end position="2000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2046"/>
            <end position="2070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="720"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="766"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="900"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1085"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1207"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1759"/>
            <end position="1770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1806"/>
            <end position="1820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1828"/>
            <end position="1838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1845"/>
            <end position="1858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1879"/>
            <end position="1890"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2070" mass="216483" checksum="3628E35B4263C4D7" modified="2014-11-26" version="1">MSRPSPSSATDPVAIPAAPPTTAGVEALAVTSPSTTTSSSTSWGTILGSTCGGAVENNRQVDTATSLNRTTEARQRMSGNPVVVPLPRLTTAELSLARSPFPDMTVLSATAAATSLTDSLTLSPRGRWRHARSDTAGAHTSREALSINTVSSNRSIACGGNRSVNPEALQGLAPIPEMWRAASLSPLHPHSPSYNSFEHEEGSTAAPTRQLYTASPPTRAFIVAGVAWSKFMDLRLMRMSRVSSKTAEAGAPRTGRQPLCAPSSMSSPVSTSTSELCHRQNALSAVLPNAPHQPQYRQGQCLSPPTSLAPLPTAQGASVVKRCEVEAKTASGSALAALATAAPVSEVWCRPVADGRAVAYAKNSEIAGGSEEFLEITSAATTAREVDLPSASGKNRSSSAIEDAGDGRGGRACKSSPSTAVASTACQRGFFHDLRVRDDGKAGVAAAALPSSLTKLNTTPRPMNSSSCGGSDRIAHSYADEEKRGPLTGVGGANDVRSLSSPLRSSVLHAVTLSHYQHHLHAQRTPSPGNEDGHSTLWRESRCGFSTVARVLSSTDKELQEPWVADHYDSPPPSFLRTMAPAPSTAATGRLLAEGEDEDAVVPEWWADSAMGTSPVAPLHATFDGYSPPQVAISSMSSSAALERQGQVAAAALTPAATPGNDKCCFGTSVGHTVQRIPAAKYFASISQPQVTDTPQVSTSSFFARGGDITARRTSVPPHASSSSPKPQSTIPTAAAPTAVSVSPLNHTPSAVPTMSLLNFASRSPTPVMNSCTTPVPSRSHPHHPMLPPQQLSPGSTSCIYRDACSGGGGGGGGSGGLGTNTTAETTSSLLLELSQLRTPPRHSVFMSAAQTSEGGHRADSTSRISISWCCGVAPPQYPSMPFTVTHPTGKCEGSEHHLSSNPNAAASASAATTTDSVMSSNTSSSATSGRAIGGSVPHELPQRATATLALVGSGNSQYAPPASPSPLPPCSREWDGGNDGAASDCPGGAAETIVQHHHQPPAPRFTSFTRVSSDSNGHVSFGSVITESDRAAQQATPLSSPQQQQQLLRCHSSDTFPTTTAVAARPLMATLGPTVRPRLHQRTGSSNSLLSGNASSRLASGIGGGNGSDTATSTPPPLSMAIASPGVALTLGTFSASSTFTGFGLVPSTLAAGRLSASISGRAYVHSLTASPPPRHRSVGSVSSLSSMGAFAFNDASTALMRQNGMSNPVTERAPSPTTSYSPSKRTHGQLGCKAEIVADDRVCGDEGEDCLGDGGASTYKIEKGERSRLWGMNSSGSRGGVHPCGKPGWLKPGTAIEVAIQAGIHARYPSHVPLFARSGDVGGARVTNAAAAATQVGDDSVWSCNEDSVTWLSCAASFTASSTLASATYASSSFGSIPCNAAAALPCPFDVEHMKRRNAQQQQRGSRDGGGNSLCDVSTDNEKSEDGPSPLCSLYAAAPRRYHYHRTLNAPAASGAVFQGRREKRHHRYVRVHHRRRQHLSLSNSPTTGRDVAVGEEQTHFTRLLPASTADINSTAAPPILSTDPAASESVNAREHNGRSQRPAGTASPGTFAAYSPHLSTSSLLYYDDVCSDDVDDVYYQIEKRLLPVVSEAERCRYSASQPAASHDNSEESPIDALFTVLNVQPRLNLRGGFHLSDYYAPCPVCHPAMRRATNGAASDADTSASSCSCSHCSCCCSSVGLRSTRRSASSSRAMSRSARSVLFSVASSRPSASWFTAGLRHTTPSPPPATPVALAARQPGVSVATAKQLDGVGIANNLNSTSTSPLQQPEREARRRERRAAAAAAAALIRTAVNHRTTTAGEPASSTPPQQSKSTQAFLSAPGPTRTTRSAAALTADDDTEDKERDAKDSRRWTRGDGNGDPARLPSPFVLTAPPRHSRYRRQRVRHPPAALAARRRKGHHGGVGGSGALRLQYSSFMQQRLLCIRVNDKLTYIDPKSATCAARLLAGAALLAEKTKRKEAERERRHRTKGDDSAAEAVANRSAPAEAFSALPTSHLPQHAPAYRRHSRCQKSHHRHHSHGECRCCPCDPLQQPVVHQRQLPTFSRAGATPGVRGSRNRVVSADDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKE6</accession>
    <name>A0A088RKE6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_120860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009381">
        <property type="protein sequence ID" value="AIN96413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697066.1">
        <property type="nucleotide sequence ID" value="XM_010698764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKE6"/>
    <dbReference type="GeneID" id="22573092"/>
    <dbReference type="KEGG" id="lpan:LPMP_120860"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_120013400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_120860"/>
    <dbReference type="eggNOG" id="ENOG502S256">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="422005at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="661"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="820"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="876" mass="89517" checksum="56C295D58126FC5C" modified="2014-11-26" version="1">MPPKLTSKNIFDVVFDQLPADAFIDTGPASLKEELILEASGMLGSSGKGPGNQRSAQRGGSNVVSSGSDGGGTTSYRRHLLPSAFVAATAAVVRSKARSVPAVPEDSPAAAVEQRKDLQDSDVLDAEELEGSTAAPLSAQAPPPDYAAASASSTVVSSEGVFRRVDDEVADLRADRFAVRRRGGPDAPKRCDGGRNATATEGGLDMQMDAEDEAVREATKYAGCVAEMQAAKEASAEQQLLCSWQPIGGGGPLVTLDARLASSKASAGIGPSFSAVGRGTELSVSCDAAAEGVATPKAMGATTESSLATPTAELVAVGVSSAAVSGAASARAEGQIGDRTLLSYTSGGSQTGSAVRTGVSGCQSASTAGDPLLQQPFGFAGAPQKGGTFTAAEQLILMPPGLDRVYTGTCVMYRHPKNFGFISPDLGGPDVFFITDSIALSFTRLALRAFYLRNGLPVPPLVAAAYRVGPAKANSIASGEDGAPTNGTTTSVVNAGTASDANGSVPAPVSSVSPGLTGMAGGISAAGDGQTRVTGTALGEEGVLGSTPVLATRAGDTGDRVLIPPTTGEELAWAEAAASLLTSATAQLLQHQVNQGIGGGLRVGDRLSFVVSRNHAARGGNGRLLRAEFLRGVPAAQLAMAVEQSWFHPLFPGAVGRKTSTPYRASLRPPPPPPSSSTAGGGGAGDEAGMSATAYPLAPFTSATSTLTRYTGCVRTYDAEEQRGYIRCDELSGSGGGNTPDVIFYPHSVLWDLTRCPPLKRQVKECMRLAYSVCGTERNGKYIATLITTPSGAPFCEDNMTFAENVLPFFAAETGGAGWRRGRGEDGNSVGGGRSAMGMDSGAGASAEGIAGDRKRVKAAEDDMLLLYAEDDYPYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKW1</accession>
    <name>A0A088RKW1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_071200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009376">
        <property type="protein sequence ID" value="AIN95804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704126.1">
        <property type="nucleotide sequence ID" value="XM_010705824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKW1"/>
    <dbReference type="GeneID" id="22572455"/>
    <dbReference type="KEGG" id="lpan:LPMP_071200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_070017400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_071200"/>
    <dbReference type="eggNOG" id="ENOG502RNRG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272536at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="362" mass="40382" checksum="F52606F89C52FAED" modified="2014-11-26" version="1">MSLRQVAALGAVSVLSVVGVVGGTRWRRVELRRAELNEEYTKLMIQMRTFNEERLTRDERLAAKEAEAKATAETVDTLWRDRLERYAQVNKDLHAYLAALPEAIGALKGLSNHYRYMLEEMPKFAGFDVACSKMHNLALMLEHSRTVGIERVAATVQEMFAAEPLVQAVCTSIVAAPAPPHPSSIAAASATFTFCMEELDHAVGTVAMRYAAVLQEPPAATPGILSDSIRKIVGMTRADTLSRGQRHLARRQDDLERMLRRAQRQLHTEEDIRAALDYTKELDDHLAAATPRRGALFLSSSSRKDDFLAAVRSDSEVKKAIQQINLWRDSAITFLVHRQAEDALQSYHLLLAEALTAVHELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RL40</accession>
    <name>A0A088RL40_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_141410</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697370.1">
        <property type="nucleotide sequence ID" value="XM_010699068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RL40"/>
    <dbReference type="GeneID" id="22573408"/>
    <dbReference type="KEGG" id="lpan:LPMP_141410"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140020100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_141410"/>
    <dbReference type="eggNOG" id="KOG0589">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08215">
        <property type="entry name" value="STKc_Nek"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000631">
        <property type="entry name" value="Serine/threonine-protein kinase NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="4"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="398"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="485"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="399"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="491"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN96717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="549" mass="61306" checksum="AE02CFC9CBA4AA65" modified="2014-11-26" version="1">MDKYTKVKTIGKGNMGTCTLARNNEDGKYYVIKQVDLTRMSKKDRQQSLNEARVLSSLRHPNIINYVDSFLARKSDNLCIVMEYAESGDVCTSLKKNCGVHVPERQVLDWLIQLVLSLDYVHQRKILHRDVKTQNIFLTNENLIKLGDFGIARTLANTYDQAQTFVGTPYYLSPELILEQPYDHRSDVWALGVVLYEMLTLQHPFSAKDMKGLLQRILAVQYDPLPTMYSTELRDIVAQMLVRDPGGRMKLEDILQLPIVRERIQQWLQGPDGVPQHYVRSLCKHHLLPASIDGATVIPSPRSAARAAAAIAHKEWCGSSEATSAHRNLRVRVLNDAGMRPLVAPRRHYSTPSAAVGACSSSTDNGTPDQVRPFIAPLKPYSNLPQVYLPRLPAVHPRAQSNNKASTPSPQLSSLFTTPNGVRSSALRNSPQQSEPVCQSSPASLPVQRPTARSKAVSRPYARPYAAQPHLLSSAGYLLMANPRRNPSDVRCQQTSKSSGPYLNPLYSTPRQMAPAYRQLTPPLSPPTDIKAMLHRAVADCARRRHEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLR3</accession>
    <name>A0A088RLR3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome c, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_161270</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="10">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome c family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN97002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697655.1">
        <property type="nucleotide sequence ID" value="XM_010699353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLR3"/>
    <dbReference type="GeneID" id="22573706"/>
    <dbReference type="KEGG" id="lpan:LPMP_161270"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160018000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_161270"/>
    <dbReference type="eggNOG" id="KOG3453">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="449280at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000014">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002327">
        <property type="entry name" value="Cyt_c_1A/1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11961">
        <property type="entry name" value="CYTOCHROME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00604">
        <property type="entry name" value="CYTCHRMECIAB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4 8 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 8 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="11">
        <location>
            <begin position="12"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN97002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="114" mass="12263" checksum="422140160C84B23A" modified="2014-11-26" version="1">MPPKDRAPLPPGDAVRGEKLFKGRAAQCHTATKGGSNGVGPNLFGIVNRKSGTIEGFAYSKANADSGVIWTPEVLDVYLENPKKFMPGTKMSFAGIKKPQERADVIAYLETLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLX4</accession>
    <name>A0A088RLX4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TFIIB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_151080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697483.1">
        <property type="nucleotide sequence ID" value="XM_010699181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLX4"/>
    <dbReference type="GeneID" id="22573528"/>
    <dbReference type="KEGG" id="lpan:LPMP_151080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150016100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_151080"/>
    <dbReference type="eggNOG" id="ENOG502S05W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272904at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041189">
        <property type="entry name" value="TFIIB_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054332">
        <property type="entry name" value="TFIIB_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18542">
        <property type="entry name" value="TFIIB_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22108">
        <property type="entry name" value="TFIIB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22109">
        <property type="entry name" value="Zn_ribbon_tTFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="3">
        <location>
            <begin position="8"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="382"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="389"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN96830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="428" mass="46553" checksum="FD968502CF593CAB" modified="2014-11-26" version="1">MATAADYVGKNCPYCGAVDSIETDEARGEAACVNCATVVAMGLEESVATRFEKDATHADVDRGGDADWDVENGGAIGRATAKNAGLTREEAAACAAGLLRCPMTAVQGTNAGPFGDTAKYAKTRLHPRMSAQLEVFFRLSRRYDEAILRDAIALAKHFVGFRRERGVRVEHQTEVAAASLMLASERLGQPIPLSEMRVLDGTLKDIESRRLEIIDATNLREEMAQMAKKYVPNLIHYYVQLLQLPLINYEMPCLALFHAIRQCESKSDPGASELAVFVEAEKVIMAVLLARTEPRLQWPNKPLPPTDPSAEPSRATLYSSFASNAHLQPVRVEKLMRVAERAVPLIQPEFNRLMQMREFTTAAVRAVGEAVVNAFVKTEEYKSTAPVKSESMPASAPSAPNSAGAGRKRNRSCSPTPPAPLSPALQDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLY2</accession>
    <name>A0A088RLY2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_160740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN96948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697601.1">
        <property type="nucleotide sequence ID" value="XM_010699299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLY2"/>
    <dbReference type="GeneID" id="22573652"/>
    <dbReference type="KEGG" id="lpan:LPMP_160740"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160011500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_160740"/>
    <dbReference type="eggNOG" id="ENOG502SAUF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9932926at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="556" mass="59735" checksum="C93428EBA8B067EF" modified="2014-11-26" version="1">MAQSALYPSEHRTLRVLELACPDSDADLRENCAYLVSQRRMTIDEAIDYVKGEEVKGKNSAATLMTTTAPSRARVTTTGATRGTVAVPVVAPEASLRSSSRLNRPPPACPRPRACECESSEAGDDNVWGAYPHGYRSASTQPSTTTESTTAATCAVPASVRSAAAPPMPADTPDEIRTSAHRTTRQQYPQRVSALTVAPPVGETSPQSLLKGQGERCISDGTAGTVTAPGADASPLRSLGRLGQSDSEPHVLREASVPIVEDAERVNGSSAPLASRPGRDAYKGGAATAKASPASLPQRRPLPPWSSVLLSSAYPGRNEGAADDDAALKAAGQRDAEDGGYCNTEPLLSELKQATEEERAAFESQQADMMYYWYREETSMFDHCLSRYGPGQVLFFTTSMTGERAVRDHCRLMQNLLFIKLIPHHTIDIADSEFFQRRVRRLCADATGTHHMPRMPLLFVDTTLIGDLVTVQELEDCGELDAKLIEAGCRVLRRRVLDAYGRRRAGLVAVPLMLPVNKRPAAMSVDPGRPSSTAPVGVSRPNVTLGRRAVTGGGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RM46</accession>
    <name>A0A088RM46_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PUF nine target 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_110740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696922.1">
        <property type="nucleotide sequence ID" value="XM_010698620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RM46"/>
    <dbReference type="GeneID" id="22572939"/>
    <dbReference type="KEGG" id="lpan:LPMP_110740"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_110011000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_110740"/>
    <dbReference type="eggNOG" id="ENOG502RG0I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272465at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005077">
        <property type="entry name" value="Peptidase_C11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03415">
        <property type="entry name" value="Peptidase_C11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="570"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="638" mass="69749" checksum="12B7AAA956028975" modified="2014-11-26" version="1">MAPKRCPNRLLVLCASINDVTAWPFWKFLQMKKIRGVTDMALLAFNSDGGSFEARIDGDKYQLKNYAKVRGYQHDMFESFVHRWHDPGRSYFVYGGHGMGDYVELEQNRVSLQVHELAGVFGTRSFEAVLFDACFMANLDCAYHLRHNTRYIGACEGYMWEPDTALDYHVFNTHNASAMSRFKDPLHILRVIQADYCSKAARGDFTIMDTTHIAELRQYVQAHVIQRVYDRATFYSLPQQERLQQMAEASMQASISEFGHPGGDSNVMNGVGGGVARLRSAPSLPEVLALSAAGRPTQRQRMRQAIQFEHALYPSEVEDKQLLDLKSYLTDMLQEEQQRRSWEAAALGPQRRVAAGRRRVRSDALQQGGVFGSAAPTSASSSFAVWRAPPSRALFVDRHGRLPAGASTGRAPLTTGGPVAANGAQEEATVPPPPPSGPYKGSAQEGLDLFHQVVVSHVPPKAASIYAAHLGGLSFTVHEYSAMSRPVEPWLVDSKKLLKRRAKVFLKNGELSEVVMESPKALAPVTSATLLAAVDKVATTAAVLAADSAGKPQHATSVTALPPSSRARMLSTDQRLSSTSSSSLTDGNPSLCLTSSAPLPTSLTDAYNRNTTVAVHDLPERAASYTPLPISKQRTSAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RML6</accession>
    <name>A0A088RML6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_130400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697122.1">
        <property type="nucleotide sequence ID" value="XM_010698820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RML6"/>
    <dbReference type="GeneID" id="22573150"/>
    <dbReference type="KEGG" id="lpan:LPMP_130400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130008100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_130400"/>
    <dbReference type="eggNOG" id="ENOG502S84W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="250850at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN96469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="298" mass="32359" checksum="48A40001B3CE2023" modified="2014-11-26" version="1">MQFRGVAVSRATRRPCPPVLITGRCFLLKPCRHAPLETSSQQYSSLLHDMECVELTPSESHTGNQRGTVPANLAGNSYYARRYSAQGDARRGTLGTSESRVQFCSGDVVLRMSLCAVPRALAHRRIVDVTGMQTSFHNVSERHSRALATVEEAMQTMHLHDGHEVPALQRGDVNLIRLQARCVYISPPPSHSSAAGEAAIVSLRHLSSVLRPLSNPDVLLAQMRRLSFRSEMEAVQAAQVAASFVAGLRGGGPVPGEHGASLDVFCSAAVLRPVVRDGHVVSMTLCPPCDARRGVRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMV5</accession>
    <name>A0A088RMV5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_131470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697227.1">
        <property type="nucleotide sequence ID" value="XM_010698925.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22573257"/>
    <dbReference type="KEGG" id="lpan:LPMP_131470"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130019400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_131470"/>
    <dbReference type="eggNOG" id="ENOG502SAZ1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="247781at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1233"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="627"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="736"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1290"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="746"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="764"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1310" mass="139872" checksum="C39CE3F4E8C0DD0F" modified="2014-11-26" version="1">MQRTYTPASHCLGARVFAHLVAALRHQSTRSAAAVAAKEVPSSSLSGGPQTLRIRSRAYGPSSDLLKGIPEYVALNVEATLHPEDAAVLRAVLGFSMPNLASVRVTPVLPHGVYETRAPHCTGAAYPTDIISSTEREVMERCLQEQLTVVANLVVDQVEQRTGHQLDALHVSYADKMKSFSEIVLNSIHDELRQLRVVRERHGSTERGIPSAAPCPSPTALDVETIARLVSARVAEQLAGVNLATPPFTTTTITPTPSSGIAHQLARLEASTAAHFEDLQKRVTIAIEGRDTPAQSSTLVDLRAAVVEAVQKVAAEQQESLSNLIGDLLTDKVAARGSGSAAAANTAFDMRTIEESVENAVQSATNELRRTITSEVKKLAKAKGTGGEVTGGAAVDADMAIEIEKVFDAVQSTQSRLTAVDETVGDVFKEQAATQDALRAMQELLHRQLNELRSTVAIAAAAPASDASEAAQQRIVEALEQLRRDVSATNAALAIHQGDTPHQLMTVAQVVSDSVTAAIQQQTGEAVQSAMSAIQEQLDALREAKGTVSVPAPTPPPPATALPLALPSQEVLTDAVEAVLSPRWAELSVQVEKMNTANQLAIEQKLLHIADSVSTSVAASLQAQLEEMRTAAQNQPRAENGDEEQDSISTNTSPVATEALMEKVTHELTTLREELLQALQVQVGKTPEVNLTPLYKYIDSVLVFMKEELSLQETNLTAKMTSLAETVTAAVHTQQEAASSSASLSRLKEEEQAARELEKEAEASKAAAVADAPPSAAPTAALSDMVELFSPMGAALEAHAAALRRLEERLDEVSRTANVSSVLMRLQAATEQFSSASLAVAAAQTSERDTLQALFQDRITSLVQTLEDRDAQLMEAMRNTATSGEMRTQLNNMQDAIQSMSQAQKEELLASLREAVSGSEKEQAQRSDALLARMAAMQEALQEQNVAVQLLLPSPALIGLSAEQQRAVARIRTATRDRLRSVTQLISNLASAPAGKNARAATKALLDELDGLRQLQDEEAAFVRETSATGAGPVTVQSILQAEVQRVQEEMHKGMQELSSQGHSLQRDIATAVQSLVAKIEDVEGSTSSLPALADIQQLLDATVVRVTSRQSDEGARASQVVEAAATRSAAELRTTVQTALAENVSAAEQRLIPAYHAKVVSTLQTHLTTHSEEIRAAVSGVTDTTTAAVQRIETIARDMTSRYSSAAQEYATSQDAVKLHLSSGKRTSYISLWWLIVNPLLVCLVVLLSMYYVFACLLLAFVPKPSEEGSSAGESATSAAAMAVATGSEPVGFSSETPRKGGRYVDQYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNY9</accession>
    <name>A0A088RNY9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Stealth protein CR3 conserved region 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_161000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN96974.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697627.1">
        <property type="nucleotide sequence ID" value="XM_010699325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNY9"/>
    <dbReference type="GeneID" id="22573678"/>
    <dbReference type="KEGG" id="lpan:LPMP_161000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160014600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_161000"/>
    <dbReference type="eggNOG" id="ENOG502QQAI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="263283at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047141">
        <property type="entry name" value="Stealth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031357">
        <property type="entry name" value="Stealth_CR3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24045">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24045:SF0">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-1-PHOSPHOTRANSFERASE SUBUNITS ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17102">
        <property type="entry name" value="Stealth_CR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96974.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1004" mass="111121" checksum="E74324FECD34260B" modified="2026-01-28" version="2">MSSPTKEARRSRCRAFASLYMRNVMRMGRRVGAACGSERAGGGCAIFLSFMFLVGFGVFFLMEVVEMTSVMSTVFFSASFSLWNRWSSGTSATVDFAVRSFAFRDMSKADQQRERELHARQIEEHLRKTPHRLKTNAAFVVMGETDPNAFRLTGDTGDSAVRPVYAVVDGHSLVRQPGTAPLPHLRTMWRTFTPAELYERYDALDIVYSFVNGTESNHFYRKRLRVKCGPQILALEKQYFLSGYTAPSITEDGSSNLTSLLSQLASRCTAFQSLLGRRNGELLQLFGNSTSRLQVDERDRETDELRHSLRSLEQHVRWHRGRVVVVSPGHHPTWVDGAKNFLAGLCGDARVQALRSSGTHLRVTTVHQDAVMPYGMRLTVDSHVIEQHLWRVRNMTAVHVYMNDDYFVNRDVAITDLFNEYGGTIVRTEEGRVAEGWRGDEGVSWAEGVANTELFNIYYLEHLHEDYLPQPLLDRWRRLLKSYAEEKQLASHELFASLEPKVRELVARARCRSSSLEDGGVATCAELEQEARYMLAFSELLKAANTSSYWEAALSNLSSTTSLPEGRQTAAQRHYYATHVPFVYCTNMFRHWSVRFRDEFAAIQLHHRDRRARDLFVPFLYNAFIMARPWEASAKFIPYLVHLKDVMEAAAAATTAALAHTPPKEMVPFIDALVEEFSKHLVKYAPNVSIFLDNEDGCAPASLYRNPAAEVMYMRATNDIAANKQRMDEVKQTNPLYFNINAGLSTAEAAVQLRSFLHGKFPTPVYLEVGGAPAAGEDLAGGAEEGALSRLFGDLMALPVVCVVSYEEGVCPLVRSLALAFAGHHRGGVRVSVEQHGGATLRETRAALGHGVVSAMPAPACTYGERVRVGPATGGEGISVIARRALDAMGGGVELPATCGGGGAGLRVRGFVVDARTRGVPVRSAAALRDALAAPAQTLSLEDFRAVAVGPSERDVVLVVSREDADAKAVHWVNGASESDLLVTYPLPVEAYEDMGAGVRWSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RP79</accession>
    <name>A0A088RP79_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_201210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698322.1">
        <property type="nucleotide sequence ID" value="XM_010700020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RP79"/>
    <dbReference type="GeneID" id="22574330"/>
    <dbReference type="KEGG" id="lpan:LPMP_201210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200017400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201210"/>
    <dbReference type="eggNOG" id="ENOG502QUC1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1695362at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039121">
        <property type="entry name" value="NUDT19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318:SF0">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE NUDT19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318">
        <property type="entry name" value="TESTOSTERONE-REGULATED PROTEIN RP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN97615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="450" mass="51554" checksum="54240C8A0D9EB935" modified="2014-11-26" version="1">MHRTLLRLLLNVSGESPDFRAKPGIRNLLLDVQQSPYKEQFKDYWSTPVPFADREYGEKPKLGEPIPARRAATTILVGHNKHIDPAKVESGEDNDYKVLMMYRESKGQYVKDQFVLPSLPVSLEDTSEDWVKVLRRRGVTTQWADLHHRLAAMRALFVQTNLLLIPKEGGGVAEVEGPPGPRRWFVICYQYAKAMRQLMDVLELPMESALSQLIPFRIIVTPTTETFRFENLSYLVTLDKIPDVQYTLSTVGEKLVWVSPMEALARFNAGIMNMPTPNVIALSELHNECPTFEDVIKKTNRDVPCKVQPVLYHHGQEKVATVLLPGDMFHPETTPEDRASKYVRRFAYEKDFPFGVRAVFDERPATVEEEAQVLEPEKPALLEEANEMDRVYSSVPYPQSQRVPQEGKTRYPVPQYVFQEGRENDEGLIPLRHDHMGRKPIDLYSSLHGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPL0</accession>
    <name>A0A088RPL0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_171010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697792.1">
        <property type="nucleotide sequence ID" value="XM_010699490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPL0"/>
    <dbReference type="GeneID" id="22573844"/>
    <dbReference type="KEGG" id="lpan:LPMP_171010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170016400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_171010"/>
    <dbReference type="eggNOG" id="ENOG502RZAU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8119704at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF5">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="53"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="429" mass="46886" checksum="EE8B50554FDDAB08" modified="2014-11-26" version="1">MPHLSTPSLLSPPQQATVLRPGDQFADVGRCRSTGCRIRLCYNTFGAVKSPCVLLVMGLASPGLFWDDHLCTLLAHSGPYHVIRFDNRDIGRSTHLDGCKGGEGALSMGSTSYLRYAYALLRPGTRTIREVYTLTDMAADAFGLLDVLGIHFVHLVGSSMGGMIVQSMVLMHPERVLSQTLMSTHSSSPRAQWPTMRDMMSFISLMPKSTSAKYESRIARATSPEERQRLCAERDAERVVVYADSFSKLLEKFSGDQSKYSFDLVAAQRQMTRIFKRSLYVNGGPRQFLAMLNAPCRDDALRQRITSVPVSQDRAEANDDNSSRHKSTSAAATPLYVPTVIIQGDCDPLVPASNARHLASVIPGSHLCVVEGMGHTLIPALRNTYIRIIRDNVRAGEAAAKLRGRKAQLSAAAVGSSSTKQPVTTVSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPN7</accession>
    <name>A0A088RPN7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amastin-like surface protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_203000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698502.1">
        <property type="nucleotide sequence ID" value="XM_010700200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPN7"/>
    <dbReference type="GeneID" id="22574510"/>
    <dbReference type="KEGG" id="lpan:LPMP_203000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000026900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_203000"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009944">
        <property type="entry name" value="Amastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297:SF4">
        <property type="entry name" value="AMASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297">
        <property type="entry name" value="AMASTIN-LIKE SURFACE PROTEIN-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07344">
        <property type="entry name" value="Amastin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="192" mass="21721" checksum="8C864B840617FF78" modified="2014-11-26" version="1">MEWSVGIAVYAVVQLIAFLLVLVGTPIDMYRFRPRYITQNTTVTTLWGVKMGGFNITNVITSDYLWRRCTNRRDRFRVAQAFAVISIFVYGAAAALGFMMLYCCSVFRLACLALNIVGALTLCIVWAAVVVTYYVEDNEFCWKESVFSTYGAGFVLLVLAWILDIVNIAFLLLPYTYADLRGSVTRYKSAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQ86</accession>
    <name>A0A088RQ86_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-oxoisovalerate dehydrogenase subunit alpha</fullName>
            <ecNumber evidence="2">1.2.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_211640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BCKDHA family.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="2"/>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698949.1">
        <property type="nucleotide sequence ID" value="XM_010700647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQ86"/>
    <dbReference type="GeneID" id="22574986"/>
    <dbReference type="KEGG" id="lpan:LPMP_211640"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000006300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_211640"/>
    <dbReference type="eggNOG" id="KOG1182">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3845at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050771">
        <property type="entry name" value="Alpha-ketoacid_DH_E1_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="3">
        <location>
            <begin position="127"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU365014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN98242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="479" mass="53276" checksum="0357602EAE6AD7E9" modified="2014-11-26" version="1">MLRISRVARCNALAAAIAGRASLSDAFRQVQNVWNVDFKDGPVTTSTLTFNEEPDPAAPIFHVLDLQGRVVLDDVMGCGVAATSFSDVNEANKIELQNAEHGEIFRYRLKDEASVITRQVAERMMLAMLTHNTMDKIMLEAQRQGRISFYMTMFGEEAAVIGAAAGLASNDELFAQYREAGILTYRGYTIPEFIAQCMGNCECDLKGRQMPIHYGSTRLHAQMISSPLATQIPHGAGAGYAFRLDNLALATSLPSGTLLSTVPEARICATFFGEGAASEGDFHAGLNFASTVGSHTLFFARNNGYAISTPTHSQYKGDGILSRAMGYGIPAARVDGLDALAVYHTVRKAREMILNSHRPVLVEALTYRLSHHSSSDDSNAYRSRDEIVHFAETFNPIQRFEQFMTQLGWWTPEQSKEIVEKTRKEVLSELRRQEKLPAWPVSTLCDDVFEYPTPELERQKAQLVEHYEAHRSTYDQETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQD5</accession>
    <name>A0A088RQD5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7883 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_220280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699029.1">
        <property type="nucleotide sequence ID" value="XM_010700727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQD5"/>
    <dbReference type="GeneID" id="22575074"/>
    <dbReference type="KEGG" id="lpan:LPMP_220280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220007800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_220280"/>
    <dbReference type="eggNOG" id="ENOG502S2BJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272226at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057205">
        <property type="entry name" value="DUF7883"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25367">
        <property type="entry name" value="DUF7883"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7883" evidence="2">
        <location>
            <begin position="302"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="720"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="777" mass="86878" checksum="1AF165B5B54B5569" modified="2014-11-26" version="1">MMSRRLYSTKRTLDFPTVDNQFVCYLRSLLRSTGPLPISKMASMIGDEHLERLGREGGGLAQFIRRHPEAFCEVQLPGCVHVAMASEACLPFRTPDQKTLGLRVIGLLAIAQHMSGTHVATSLGFVTSTPTINDLCKALRCWALVTPMQLTRFLRQHEEVFWCHPIAQHVRLRCVKPLSTPPSSPQQVGPDRASSSMKNSRLQLWLSTVVPSQYHVPLSYLMDSVVMTNMSVSLFDCEAPSLRDFRVAFQQLPPQFVDVRAFGDSPMAVFVRLLRPEPLLLQVGVPSYTFDTPAPEIAASRYDPTLLGRKLTEALQQGAAEDRLKHLRLVKGLHLAHLRDFVPAHLVREIEVFYGLVEGGDLRVSVLLLDRLRHLWEVQLESSQVRPWAFLPSSDQPSSLTLETSPVPRVMVRLQRILADKGAQLPTDLYAELPGDLQAALLRIYGAFKEAGESWNAAVPSAPLQSPDPATVVDAISSFVHTHSLFFIKQGDVILTPRLAAEEQRRPMRSDGAPLEGRCPEESPYVGKPLGPTSVSRRLAKREGEMSEDELARFLHDAIPAGQPVIVDALRTTLQNERFRRGLTSEQARRFVRREFFERHKGYFKLHEYFAYDKLVVGRAKDPPPPPHVLQPRITRIEQVIKFMALLSSQSATDGALTRALPREGRMLVKAVGSVTDIAEQLPMWFLAQRDKNNCSSSLIRYIGPLAECEARSAWALKPPPAGVLTRKVPNDPFADIGSEEVDGKPSGWNKEWDEDEHDRGESQEASVSPMPRASTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRC8</accession>
    <name>A0A088RRC8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Agmatinase-like protein</fullName>
            <ecNumber evidence="4">3.5.3.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_230080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.11" evidence="4"/>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699167.1">
        <property type="nucleotide sequence ID" value="XM_010700865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRC8"/>
    <dbReference type="GeneID" id="22575212"/>
    <dbReference type="KEGG" id="lpan:LPMP_230080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230005600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_230080"/>
    <dbReference type="eggNOG" id="KOG2964">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="288726at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via agmatine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="ARGINASE/AGMATINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF26">
        <property type="entry name" value="GUANIDINO ACID HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN98460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="332" mass="36577" checksum="02EC8C47E24FAAA9" modified="2014-11-26" version="1">MFTKFLSRVRALPPRSGDWANKLGPVALMGYSGGAHMSSTKLLNHFYESPRDCDMYAELTFHEPGPVECPPETVIFLPVIQCGEMLNDTNEPSGVTKDDWYVALTEATTELLEKGYVPVSAGGDGSATLAMIEAYKRLFQSSEVVLIHFSSKPSLERAEQPIRVLLEKDLLKGVVEIGNRCVSSGDRKIRKQNKIMYMDIQAIYAKGLFCIRDIRNDYPVFLSIDADVLDPAFAPAVQSPVSGGLSTRDLLHIMTGIRGPKVAGIDIHGYHPTLDVCRGDGLGLTQMALAKVLKESIVKAYTISTQTAEEGLERVRMLQRQGTLSDNPYPDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSM6</accession>
    <name>A0A088RSM6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_211300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698916.1">
        <property type="nucleotide sequence ID" value="XM_010700614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSM6"/>
    <dbReference type="GeneID" id="22574952"/>
    <dbReference type="KEGG" id="lpan:LPMP_211300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210017500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210017600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_211300"/>
    <dbReference type="eggNOG" id="ENOG502QVH9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5598268at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001002">
        <property type="term" value="F:RNA polymerase III type 1 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001003">
        <property type="term" value="F:RNA polymerase III type 2 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019136">
        <property type="entry name" value="TF_IIIC_su-5_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040454">
        <property type="entry name" value="TF_IIIC_Tfc1/Sfc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230:SF5">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIIC, POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09734">
        <property type="entry name" value="Tau95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor IIIC subunit 5 HTH" evidence="2">
        <location>
            <begin position="326"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="637"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="665"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="693" mass="75932" checksum="D40797E3CCBAFD2C" modified="2014-11-26" version="1">MTAPHDSPTAASTGGEQLAMPAFRSYISVELPFTVTPTVTTSSAMLDGADQLSTSAHAGERREVEAFLPASFVVPCLHHPTPQQTMARSDVSGAHDNGEEPEGEEESGDDMPSSNSSGDSDESASRAFPYTVVKRPAVQAARDGGSQRRALRLLTRYHRHYCTVPIFSGWRSTNWGSGGDEEDEEYWASDSGVGGGGGAEAAHLQAQKRRRREAFASIEPQLLVNGYYRNDLLLQVRQCRHIRRYRDPFTNAVLREEEVDNVEEGQGGSAHDDKDACGTARTSSVSAEVVGVVSREMELARPADFTFALFTPEQLQAAPSLCGAGVFPPQHFLSSRAPFEVRYEPGRDLNTAVAAASAATAPGGDRLAVDANDDSSAAQYDLATLPTISVSAEESSVLPTRQAAHNNFLRSMGSSLDGGLDTDPPEVQMMVRLLAERPSWVVQDLQDAMLQSGLCPRAYRNKQVMQCFTYLIRNGPFNRLRLRLGYDPYASASSAVYERIAVRLLRRSDVGVRLRDVSRSPHIESVLRLLLERDKVRRAAYKGLPGHARRLTLLEMQCRTIGRGQLYVPFQLADVMDDPYMADVVRCVEPATAPMELARRGQRRGWLSEAAYLRATAHYSESLAALLEKEVEPRLRKLQGEEDAEKEAEDANKATESSTSSSRDEELEVDADEDDSAMSCVSSGEFSAVEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSY8</accession>
    <name>A0A088RSY8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pseudouridine synthase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_261140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699934.1">
        <property type="nucleotide sequence ID" value="XM_010701632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSY8"/>
    <dbReference type="GeneID" id="22576017"/>
    <dbReference type="KEGG" id="lpan:LPMP_261140"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260016300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_261140"/>
    <dbReference type="eggNOG" id="KOG1919">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="424794at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF77">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="672"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="763"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="958" mass="103226" checksum="82FA090871365576" modified="2014-11-26" version="1">MSAPRRPCTIVELQQLEEEAWASPAQRALYSTRHIPGFPWHTVQEVSSPDKPAAANATALFTTGARRHVIPYDFLFTVFVKGRWVGRRLLEVYTKELPHHTPAYYEACLRKGRLYCVQRSTLSRHNTQRRLLKRSAAMPVSVGRARSFSDNALDQALSSYTAPTTTEMSGSDLRQRFHSDCRAASAAYPPSQGENVVLQHGDIVYHTVHRHEVPVTLGVTGTDAVLITAVCITHYGLICVNKPTGLPTHATGRYYYNSLTALLEYVLAPKRLAAWLLLEDPLLQSLVSTELLSRGEKSELYAYYAPPPVPVRSTGSVHQPCEHQVNSERNTEPRLAYSHCDCATATDATASRGADLDEIDPEKVPRPCHRLDKVTSGVLLLAVRQDAAKRIGLVLMRKAKEVEEAVAAELLGHRTEPPVSRECLCQTAVTPVAERMASHNGCDGDTGLPALGASSSTSPSLPTSLQRILAGTYDLQKYYLARVRVESTGVLPASGKTSEAETQRQHTLDPPPLTSPHVPLLPPSPLNLWRVSGGEPCLRTHNAYLSRMLSSTNGVCDIASVCACKPMKCTSALPGVFPDGVLTTVPTPAPETLTPSAAAAATLFQCLSALPTVTTAAHQHSPPQTGTSVASATEEALVLCTPYTGRLHQIRMHLSSLDCPIVGDVVYARTTGSADVPDKSSTQAQPQPLRGKPRDAEDVTCDSDTSSTKATAARYPDTSVDCAAQLPSDDRNFVFFDAAQLPAAYRRFAKAMKTAVSGVDAASCSHQTSPSSRKEEQAVIVDADDGLRAKSGVKRSRAESSTGGGREAEMTEDMANLESQDARVANTTRAGVVIGAETVEEEQSSAAITSWQDEPLCYECAGRLPVVAAGECTTGTSAICLHAWVYQVREALLLGTDNSAPSKASSSSASHFLAFSEDGARGAQMNKHTPQCSPSRGRVVVENDFVCFEAPPPAWLQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RT20</accession>
    <name>A0A088RT20_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside triphosphate hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_252510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699820.1">
        <property type="nucleotide sequence ID" value="XM_010701518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RT20"/>
    <dbReference type="GeneID" id="22575899"/>
    <dbReference type="KEGG" id="lpan:LPMP_252510"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250027500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_252510"/>
    <dbReference type="eggNOG" id="ENOG502QVFA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270417at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="445"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="640"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="958" mass="108942" checksum="6DE8FC1A7C8DD997" modified="2014-11-26" version="1">MEAKIAVCLHDLKSSSGQPAALRVSGSAVAFTCPAALKEASFPANDTNFTVENVLERPSAAAIQKKMMPSAASDFKNHQNLVVFGYGVRSTPKRQLMYGTRSEEGYATRTITDAVCGSQGIFTLSCYVLGQSEHLVDLIKANNELGVIVESVKSGPRVRMVERSRVKTASDIREVFSKIVKNYEKHFEKVLQEKQPTAELQALPPYQGDSIILQLFRYDTEEAFTEYDEANSMTFVALGDSERPVLYGLDSSQQSVFEKTNRVLVSAAGIMSSIKCSRLRIPFGKSKMSQLLRRCYNAEKGNNYNSVNGPTNTVMLIHCWTDAEWAEESYHNLSMIRRICNTLGSSGIGSILRDLALEKWRLDQDIFELRDELVVARTVYEYKPCICEVAKPVNDIKEEEMKRVTAIQSKRDEGREKKLSSIRSSAKEEAKKIIKQQEASSGTTLEALQKTLSIKKRENESLQAERDSLTREYEQALDKIRQRKEEEEEAVARLREEMVQLEEELSARQEAILSKQKQLEMAKLDKAKCREAILRERENVEAMRKALLAERRHQRQQWIKQIKDINDKVMKQLSTIAAERKKKGEKVTSKEEASERAVMEDIKTIEEYLPKLISLEDVPVNPEETESIRRQFDEVFTQEKKTYLSKIEEEKERKEKLEKGLDAYRSRLLEVAHAKKKESQQDAVRKEQQLSSLVEQVLTYLRHGVKMTKISSKGLARRRFYFISDDGTRMHSCELDNQGIPINRRKPPVTLLLSDIRKVVLGVYTETFLTFSSESQLAKARAEAITDNGTFRPDVTQDITPANLGLHNYRAFALLLRGGKSLEVVCESDTDCEAWMVGLRRLLSIKTATEKILEHHVEPGRIQEGAAVEKPAEMKFGGLLDVRNMRGFVSLSPEEATLCSESHIPPALFLRVKQEVTEKSHTCFITVYDVRVSSGLDLVRSTYIYDYLVQYHIIQLPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RT69</accession>
    <name>A0A088RT69_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_262290</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700049.1">
        <property type="nucleotide sequence ID" value="XM_010701747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RT69"/>
    <dbReference type="GeneID" id="22576132"/>
    <dbReference type="KEGG" id="lpan:LPMP_262290"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260027700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_262290"/>
    <dbReference type="eggNOG" id="ENOG502SHT2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1068471at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050505">
        <property type="entry name" value="WDR55/POC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019:SF8">
        <property type="entry name" value="POC1 CENTRIOLAR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="528"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="528"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="557"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN99342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="735" mass="78657" checksum="F5EE286B29448197" modified="2014-11-26" version="1">MPSRVTIRCLAAYTNDVEESGGGLVPLFVGREDGTVERYDAIQDAELGIPTVSFYAHRNAVTAIVALSPAELYTCSLDGTVKQWMLEEVEGASSLPSTGGLRARAVLVKSSAFPFAVCTMVQDGNDGVAAGQQRLFLGGVNGSLTLMDGDRRSTWPAHNGGALTTIAVDWNNSGSVITGGTDGLIYVWDMESGRPVCELRGHTGAITSLFVVPVPSSIPVVRSKRAPADPALFGSSTALPPASETKDVLVYADADEDGGSASCLVSCSEDSTLKVWLLPDLQEAAAEADLMEREQQQQQRHNSEDGASPQRRSVCISFQDIEPAKLVAEEVSEETVGVAPSSESSTDGAAVIAAATNASGEDVATDAATSPTATTREPESQVYNAKLHFLQQQAAGTAWKSALKAPERRTVPFHSALGTVELPHRPFSCSGASPGMSDGGGSASSLAFIGAAQGYVYGLKDRLLVKEVCQHTAHNFQKVQKAVRSVQRTLKDGVKVYTRAAAAAMKAMEAKELKAAAKACQVQRAKERAAKKKEVEERRAARRAAAAAAAEDRSDKEDYEEEEEEEELEELEEEVEEDEVEEDEEPNMEETEKLGYTSEAADGEENGVEGMALTFTRDNLAPRRPASWKKLTEEQRAALEAFFAAQEKKRDEQITALRKSVEAHLTQLQPLTKTPYHRSREQFSNLPYTTMGCVRGGSAVVSLAPASLVPGCDKVYVTQANSIAAVAVQFGVTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RT90</accession>
    <name>A0A088RT90_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endoribonuclease L-PSP (Pb5), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_230220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699181.1">
        <property type="nucleotide sequence ID" value="XM_010700879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RT90"/>
    <dbReference type="GeneID" id="22575226"/>
    <dbReference type="KEGG" id="lpan:LPMP_230220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230007200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_230220"/>
    <dbReference type="eggNOG" id="ENOG502QS7E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="CDD" id="cd02199">
        <property type="entry name" value="YjgF_YER057c_UK114_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013813">
        <property type="entry name" value="Endoribo_LPSP/chorism_mut-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43760:SF1">
        <property type="entry name" value="ENDORIBONUCLEASE L-PSP_CHORISMATE MUTASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43760">
        <property type="entry name" value="ENDORIBONUCLEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14588">
        <property type="entry name" value="YjgF_endoribonc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endoribonuclease L-PSP/chorismate mutase-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="157" mass="16478" checksum="16F62E986C11D768" modified="2014-11-26" version="1">MSGTVESNLQKLGITLPAPAAPAASYVAFNVVGKMVYISGQLPKNADGKLMVGQLGDTLTIEEGKAAAASCAVYLIAQMKAAAGGDLDMVKKVVMVRCYVNSATNFHDHPHVANGCSDLLVKVFGEEVGRHARCAFGVAQLPFNSAVEIEAQIELKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RT92</accession>
    <name>A0A088RT92_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_262550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700074.1">
        <property type="nucleotide sequence ID" value="XM_010701772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RT92"/>
    <dbReference type="GeneID" id="22576158"/>
    <dbReference type="KEGG" id="lpan:LPMP_262550"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260030300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_262550"/>
    <dbReference type="eggNOG" id="ENOG502S99H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="250921at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="151" mass="17024" checksum="E5C448F2BB84E6EB" modified="2014-11-26" version="1">MFSIAAKQVHRQQLLQPRLALPAGRTVSFEEGRRLAMLVHDEENRLQSEVTHLLEVKEASPVVLAESVSKRILLLRQKQNGTANVKAAVAYANRLHRKSAVQPEDAAKMREAASRVLRPSSSLGSTGLKQRRQRTEQTKKQRRSKRGGKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTG7</accession>
    <name>A0A088RTG7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HEAT repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_261760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEATR1/UTP10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699995.1">
        <property type="nucleotide sequence ID" value="XM_010701693.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22576079"/>
    <dbReference type="KEGG" id="lpan:LPMP_261760"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260022100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_261760"/>
    <dbReference type="eggNOG" id="KOG1837">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="31183at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001009">
        <property type="entry name" value="Hypothetical_protein_-_conserved"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040191">
        <property type="entry name" value="UTP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457">
        <property type="entry name" value="BAP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="759"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1696"/>
            <end position="1719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1898"/>
            <end position="1934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2503"/>
            <end position="2529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="764"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="776"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1696"/>
            <end position="1705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1918"/>
            <end position="1929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2519"/>
            <end position="2528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2766" mass="296897" checksum="23B1A8B01B7B2679" modified="2014-11-26" version="1">MTSQLASQLQQLQQRPDGSGHRLAKSFLFSTQDAQSFSREQIHQLALNGLQTLTAMDNRFHPFIQNLFDVKHVRRERSMLTTAEDSTLRRRLEHFLSLLSPHLFLTAAQQVLEFLVRVYEVHIYDAASVLRAFLPYHDHNIFARVLLLLDLRDTGFDFLATNQLHGAPLLREHLVLACAESRKAARLLCLTVAMPFRYGIRFHAANALFASVVTQLATHKNAEALWRTFLPFVLELLSGAVPSAEAGTAELVGEGQSDSAHGGSNRVSTESVATALVVLTAWSAHVRFSRAMLITVLKPTFRYITAAAFAAAGEAPHGTSASYLPVRDLLALLEIVLATQHRALVDVSFAPLLQTLLALPWRTLTSQLPFSEVTEVVAGPNGVPTTSPRHSVLLATLLQTALERLSSASEVRLLPSDVVEFLTCAAEDLPLSNSMVARCLRVLMAAEAGTSPAGAVHDGSVRAAEEAADKSLYYRLVVALERRYTIVFDGVLSEVFLHPETTTAAAAFLARYFSGTRYSTVEVGSALSGATESLPLFACFLHPVPEVRALAAKTLQGMSITQVMCGASTTSDNGQSLVDLLAHAIAYEHDCTAAEVFVTTAAAVVERLATQWSGEKAKEGDELGCRAACQLVRSLYSMVLAWSPSETSAAPGSAATRAAAQRRVVLPLVTTFLQPALLMWTRSASATTSAAQDFRTSVLYHSTLLYAQWAGASLASMQTPGEDVALVAQVESELVTALEAGCGGPRGLAPLLRTGAVSAKRQGKTTARNSSSGKMEWQRVGRRGVAEAKSDSDVEEEQQQSQAGGDCNDSSTIRARTVCFSNILECDVLLNAIRTEAQRRLPDAFAAARTAVREASAVLSSAASGEVEVGIALAGALLPTVGEGVPTEALETVSAIVNFLHGSDAADETAMVSSATTAAAAVGYLEVAYAALLANGSGRRVAQVGRGAVDVATVAREQLYQVPLVAQVGAVLRAALTRVLATAATVAVASESSSASLVLRLCQGLGFVGAALPSIVAQPDTLAPAYLELTKNMTAVTLAAEARSSTAAALRQVDWYALVADAVFGPAEEANHDSCVRPNTLAALALVLFLPLRASSTQRLIQLRALQESVVTTGAQHGSTRGGASRLTGAQVILAAAMQPQPQKGTSSSTSSSACSVTALSCLIECMAVEERQYQLSPSAAALVCLLLAIHNGTDVSAQAYVVPAEWAHRIIRYFFRSHNSHGGERARAGSSSAVAASSSPVMTPQQVSLIKAMLPRVEGILASAKGVDASSSSLCIVTADAADLVDAVCGCLHIWGEASTKDDAVAGNASVRLVELLLRHPYTHVHGGGTRPVYRYALAALTVGLSYGLKGRQPTQSTIFKVGKSVSTAASRKGEYAISAEYQRLVAARLQPVVLHAMDVIGTDVGLACMGTLGGYEYFFLPLVASVESAAAAVGGRQPVLSKAKVAHGRTSPVIGTDHETASEAAAVLLKSLREMLETLVPSTAAAVSETPSAKHKGIVDCAAEGEEGSASTSVVCWRPPASAAVANPLTFADARRVLRLPSVCGAAAEGTGRWTLGALSHESLGLLRTLLRVMPTVVMDDEDDSESVYALVMECLELYPLQGMEVLLRRAASSAVADDVAMLPRIQQLRLGARGSVQVEEVLRLVETLVQVCTDQTRLLSEKVTDGAHRIKSLLLREMMVLMARVLVDDNAEDDGAEKDEEASATSPKRAAVDANTAERRQSELHFHVDTIAGLLRATAPLLKMPTGAAAAAATACTSVAKSSTYLHIPLVSLLIKLEPFDNTEALGFRSAREVCQEILASFGIHTQVQCLGQLMRLVADPVVQLRSGVNAEGDGGAVNGEEHQRMQHLLRRMVKPNQVINRQETIMHLVNLTIKSDLFLEPFLALQLHARSSQPSRAAKKRLQQQQQQSKQKSPRIDGENEKESDTDGDVVEQAEGAAQREDGGCMELLVSALELFAHYHDLQETTRRSAASVAAGAAEEEAYTSLLELLAGNTLACVLAGINEPTFVVCQQRLLEDRRVALRKIGLEVLLDRLHHSLPTLENVVSDEEMEEHRRRLRDPRQRLSLVDLVRIKARPLTTKRSIQLFPLLVAEIKTSLGQFHATLQSASTAGELLTRVQLSVAAVEELIRIVSSGGSLQSEKTLLNASRSKRVTGAALVKLFGNRSRVTEVHELVDLICNHWMPLLTRCEMRLRSRTGQPGADGSSYYSTTASYSSAEESVLGCMTCLVTALATIVQVMGTAFASTHCLSFLHTLVSAGVYQVVEMPGVVSCGEAGKLLRHSTLSSLIRCLPACWQMTQPYLPSMLFLATHLRNVTDAESHYLCAEMLAVLEAVMEPQLLLDAGTTCLQGLPYLNGALVPASEQHQLADLAAEAAASVSESGKAKKGTMRVRQIRAQVHTHSFSLLFTCFERRVENMRKEELLHMRMLMDGATPQQNFWLAAFQSLASAPSVPSSEAVMPVLQAFTVFVLKFQAKHSSRLLRIVADWAFAESSGVVTGASRKRAVGPGDPDSNTAEEEHNGRGHDGVAQSISRVTLQSWIVFFALSNHLLGKLGSILDFAFPIFLPHAVTALRMYCATTATASKVMDSLVALVLEGALECMRNMALAQTPGPDHDYSIQLDVYFAKADVFPSVMPALVHQLHNLHYLEDSQRDYRFRAEHNVIPAIRAFMACLGSSKLQSKTQAEVVRDLRHPSRHVRREALICLDGIYADGGDELASRLMAEMLPTVIELTEDRDDAVVEEARKLCNDLSHMTGQDVLYAMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTZ6</accession>
    <name>A0A088RTZ6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_272280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700314.1">
        <property type="nucleotide sequence ID" value="XM_010702012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTZ6"/>
    <dbReference type="GeneID" id="22576406"/>
    <dbReference type="KEGG" id="lpan:LPMP_272280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270031100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_272280"/>
    <dbReference type="eggNOG" id="ENOG502S4CV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="258005at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032065">
        <property type="term" value="P:maintenance of protein location in cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024774">
        <property type="entry name" value="PH_dom-Mcp5-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12814">
        <property type="entry name" value="Mcp5_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="10"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="130" mass="15450" checksum="E27EFC1F115033B8" modified="2014-11-26" version="1">MDLRTSVETLRGGDWFYKWTAKGDSVHRRWVWIDTKDYLLVWSNYETYSPHFCGNVRLDHICQVTSHDLSSMDENGLPKTYYVLLIKTRKRVLQLATELKYKCDAWFEALNNVMRFIHRNDMTKGALIPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RU61</accession>
    <name>A0A088RU61_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Basal body-orientation factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_241620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699501.1">
        <property type="nucleotide sequence ID" value="XM_010701199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RU61"/>
    <dbReference type="GeneID" id="22575571"/>
    <dbReference type="KEGG" id="lpan:LPMP_241620"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240023500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_241620"/>
    <dbReference type="eggNOG" id="ENOG502RXRE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="441129at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14845:SF6">
        <property type="entry name" value="BASAL BODY-ORIENTATION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14845">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING 166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="343"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="552" mass="61437" checksum="06E28589171B2ABC" modified="2014-11-26" version="1">MSDSPNTAAVLPSLRKSMAASATPGQRPRDGASILALSGSNNNRVSVVGSYKAGSKLISGSSGTLRKSRSSTTAELPAEMSRRSVGMSDEALLTSLVTTDLAATKVATDTYYNQYKEAEAENAKLRAALRQQEVDSVQVVQFLESKLREVEIETQAYKTGITQLLDDHHHAEEELQSKYGEMLRERDIELTRYASVTTRLHDDLRQASRYVQQRQEHTLELQHLQTQLEDLVVEHEKEVAALHFQTVDRKLKLIALEKTMRAEFDALVEARAAKALEERFQRVLERTRRLEEEKVSMTHDIHDLMQLTTDIDAERTQVQRQAAVQQQAHKELVHQAMARGRQKEQADLKIYELEERVRELTAQLQVVRVELQASYQSRIDVLQTELKSTRTSLQTHRAELLHMRQLTARVVGERSELENFFHTALADCQRYRHAMSANCHASTAASATGASKGAMLLENVDWGGSASRGGAPRQTPQESVMTVAAAASPAPSSSSLAATLKNSGVFFEEMPWKDKEKVIKALLFFLNANYYKSLSPAPTAAGSGPLDHVCAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RU62</accession>
    <name>A0A088RU62_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine peptidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_272590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99637.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700344.1">
        <property type="nucleotide sequence ID" value="XM_010702042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RU62"/>
    <dbReference type="GeneID" id="22576436"/>
    <dbReference type="KEGG" id="lpan:LPMP_272590"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270033900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_272590"/>
    <dbReference type="eggNOG" id="KOG1051">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000120">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000025">
        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000010">
        <property type="entry name" value="Chaperone clpB 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF176">
        <property type="entry name" value="HEAT SHOCK PROTEIN 78, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN99637.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="817" mass="90820" checksum="BE754176C005A1E6" modified="2026-01-28" version="2">MMRRCLMEVAAAMQCGRTATLAAPFAPSICGGTCKAPVAAVACSLLGSSTAAHPVLTTSCRWQSTGVTPWSSSGNNDGGGNGGQQQGRTWVNPNAVPPGEFLKKYARDLTEEARMGRLDPIVGREEVIRRTVQVVSRRTKNNPVLIGEPGVGKTAIVEGLAQRIVKGEVPESIKDRQVYALDMGTLVAGAKFRGEFEERLKGVLKDTIQSQGKVILFIDELHTLVGAGSSGDGSMDAANLLKPSLARGELRCIGATTLDEYRQHIEKDAALARRFQSVLVTEPTVEETVSILRGVKEKYEVHHGCLIKDEALVYAAVNSHRYLSERRLPDKAIDLIDEAASRLRLQQESKPEALDLIERELIRLKIEAEAVKKDKDEVGKEKLVNLYEHISQKQREYDVLEERWKREKSLFQTIKQHTEELDVLRHHLEKAMNSGDFAKAGEIQHSQIPNLLKQIEKDKHLASSKNFMVHDSVTSKDIAEVIARATGIPVAQLMTSEREKLIHMDAELKKTIMGQDAAIESITNAVRISRAGLHSHKRPLGSFLFLGPTGVGKTEVCKSLAKFLFDDESFICRIDMSEYMERHSVHRLIGAPPGYVGYEEGGELTESVRRRPYQIVLFDEFEKAHPGVSNILLQVLDEGHLTDSHGRRVDFKNTIIILTSNIGADVIARLPEGVPSSKAMPAVMEQVRQRLTPEFINRLDDIVMFNRLSREDIRSIVVTLMAQVQKLLTEHNITLEESEAVYDWLSVNGYSAVYGARPLKRLVQSELLNQLALMLLDGRIREGEHVKLSVQDDHVVVVANHTLSPEKGLSDEQLLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RU87</accession>
    <name>A0A088RU87_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA exonuclease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_270980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700187.1">
        <property type="nucleotide sequence ID" value="XM_010701885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RU87"/>
    <dbReference type="GeneID" id="22576276"/>
    <dbReference type="KEGG" id="lpan:LPMP_270980"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270017000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_270980"/>
    <dbReference type="eggNOG" id="KOG3020">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6079689at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000151">
        <property type="entry name" value="TatD related DNase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050891">
        <property type="entry name" value="TatD-type_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060:SF14">
        <property type="entry name" value="RELATED DEOXYRIBONUCLEASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060">
        <property type="entry name" value="TATD FAMILY DEOXYRIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="379" mass="42307" checksum="078680AF17E12042" modified="2014-11-26" version="1">MLAAAQLRTPPYLVDVAANLTDGVFRGMDWKGNRLRDDDFDNVLARAQERNVQQIIITGTSLAQSVKAIALCRRYPDRRLLCTVGVHPAHCGEFLRPLDLNEIRGVAESDTSMVVAHHNKSAAASTAKQEEVWAQERLDYLVNLVNKNRDVVVAVGEMGIDYAELTCCPREVQEKYFARQLTAFAPLQLPFLFHSRGCGMSFVHQLKDIWTRIAADAAATGAVPDIEGAPSPSVNAQLRGVVHSFNGTLEEQEALLLMGLYLSVNCSAFREASLAAQVTSIPLDRLMFETDAPWCDMRWKDYGAQFVRTIFKTTKRNKPFVMGTCLERRNEPCHLVQVMEEYLGCRKACATGPEDPLSRMDEATLVAAVYENCKHLFHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUE4</accession>
    <name>A0A088RUE4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dual specificity phosphatase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_250240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699596.1">
        <property type="nucleotide sequence ID" value="XM_010701294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUE4"/>
    <dbReference type="GeneID" id="22575672"/>
    <dbReference type="KEGG" id="lpan:LPMP_250240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250007500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_250240"/>
    <dbReference type="eggNOG" id="KOG1719">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273181at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46274">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46274:SF6">
        <property type="entry name" value="TYR_PHOSPHATASE_2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="1">
        <location>
            <begin position="211"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="327" mass="35987" checksum="6B867BD21F71FE94" modified="2014-11-26" version="1">MQSAVEGSGPFTREEESRMHLLQERAQEGGSLTEAESVELSQLKRRYHTFIEEGERLLRANAPAQASGGGTTTAAEGEWRTAATLSRAGKAAYFWGSLMATALPGYVGRVAGVTTDFLHWNWITEHLVLGAIPIVTQIGSSGDHLSQLRAQLDKRQQTLGLVIACLEEEELNGFGMNVIQFAKEEEWRKLVNPHVEYVRVPMADTTANTPLSAVALAVTRMEACVKERKQTVYVHCKAGKGRSWMVMMCYLTTCGGMSFAEAVDLIQQNRVQVNPSQSQRQFASEFPFRFAHSRSLLDSNQAGGCHHNGGHHCHPHEACHHGTADAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUG4</accession>
    <name>A0A088RUG4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside triphosphate hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_250490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699621.1">
        <property type="nucleotide sequence ID" value="XM_010701319.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22575697"/>
    <dbReference type="KEGG" id="lpan:LPMP_250490"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250009400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_250490"/>
    <dbReference type="eggNOG" id="ENOG502SM2A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266220at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1292"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1372"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1019"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1372"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1385"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1399"/>
            <end position="1413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1521" mass="163671" checksum="F4F98E62389A1D4C" modified="2014-11-26" version="1">MCRAALWASISVSPGTLAADHTPPRQCVATSSRPMVSRDWMLHDILVTPLYVCVNSAAVVPLSTNTCLHLVRRLASGGESVNAAEVATAGSADLDTLLRESPTCGALVYALLQQRWRMEQCKIPPLLSILDSNAFIFAEGSGFTQHEEALAADVYVSVVPSLSPSTHSSETPSSAAIMQLMTSLSVAHGRGSDNVMDCRSEAWAAELSKHILRRWARLSVQVVLCCGESQAALRHRRGLLLRHASDVQRDTTPAFSTPNDAYTRKLNAALHLLDALRPTSTSAGRQICDGGEASCSVVVDALDVVLEKCEDDGSGRHHLLRGCVRRVVAFAPTAAPHCGVDEPRLAPEPDYLQLPWCVAHSAALAFTSAQARAASASTPHFSASNAASAPIPPHVHVPLPVLDACMNDLHFTAEQQTCLHELAYSVVYLASLTFTPQGGSSASPAKVASTSLPALSAAAKFLRLPTSELVAALTTVEAREDDQSTTSAARHALNCTGATQMQRVLVAHLGGLLVRTLMHLINMALHVDGRIGTDARALVLAATTDAEDTAVQAPPAHMPDTDGGSHGGSGGGLSTWYAAYVRCHAAAAVRDRLVGALQREACYEGVESEVDSWLDKFSAASTAPTSTALRLRPVAAEVREVATRVRMPSAKQREAGTIFTTHATAAAAYDSVDTTCDIPVIAELARILEAVTLRCSDTDVFAAPPLSSPAAVQRLLAEQLQELAASARQTVAREDDGTAIRAEEVVCTWEGTASADSSPCDGVLVLTFPCGLHSSLRLSVRRLAADIFAAARLCVLGTTPAVQHILHGVREWCASLTSMVISADDRRRSVPRMGQSPLQSLEGGRDSEGVMGVLFPVSSCSAHEALQSTLALHRRSRSSISNIVRDADHRDTTTATLTSDFFYVMLSIPVPAEASSWGTLPGIGDLEKHRRGSPGALPFLELLPPDEAPMSFTPASNDALTPDDVLTTYLRERDPLLLALFFWSRLCHCLVCPVPAFAKTFAVPLLTSYAQRRPLTGVSPRNTTSSSPSAGESREDALSESGLRTVADAASGAPVQTPRWHMRATAPDAAVAEFLNRVRHLQRQARYRELCLLALQEVPCCGDGGAVLGVSVVFLGAAAVATMQSCRVELRDTAVRCLQAAGRGFLSRRRLCFVREQRRQQLDQQRHRSLHLTNSCLVDPAAASSVEMREREVLERMRDTQLAQSAQHRINALTDSTRRLSHTVGLLQQGWTETLELLEEELVGSAMQINAYEKQRRVAEDAARQEARLSLRVHEEAWSDVWMGAKRRQAHRQAALAGRQRRRPSPLERRDAESTAVIEEGIRLATTTAHHTSQLRHKAALSAEAALLSHLLSANRREDAQWLAGHVRRQEARVTHMADRRQHYGSGGGGGGGGGADLPEERQRRGGRREKGITETPARPAESPAGFSRLQHSNPEGLVFTRPRHAKGKGNTNTAPTSPLGAGHTQLVAVSCRERGCPDVAGRMSIASIERTMTATATEDSPEWVVQRDLMSLWESSRMSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUK1</accession>
    <name>A0A088RUK1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ribosome biogenesis protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_281990</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. BMS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700539.1">
        <property type="nucleotide sequence ID" value="XM_010702237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUK1"/>
    <dbReference type="GeneID" id="22576644"/>
    <dbReference type="KEGG" id="lpan:LPMP_281990"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280026400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_281990"/>
    <dbReference type="eggNOG" id="KOG1951">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10260897at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01882">
        <property type="entry name" value="BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000105">
        <property type="entry name" value="BMS1 ribosome biogenesis factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037875">
        <property type="entry name" value="Bms1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF2">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BMS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51714">
        <property type="entry name" value="G_BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Bms1-type G" evidence="12">
        <location>
            <begin position="85"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="429"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="542"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="594"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="641"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="704"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="738"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1199"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="602"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="641"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="658"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="710"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1199"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1218"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1240"/>
            <end position="1250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIN99832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1256" mass="139901" checksum="DA1BFDE8EA7113C7" modified="2014-11-26" version="1">MDEPQRNKPHKSKTVGNKAAKKDALRKRRVGIDLEQNRGSNVKAFAGPSAGGHKAQKFFRSIEKKETALHVPTMDKTLCHVVAEPPLLVAVVGPPGVGKTTLIRSMVKFYSNRNLTSVRGPVTVISGRSRRITFMECPNDLASMCDVAKVADLVLLMVDGSYGFEMETFEFLNIAQVHGFPKIFGVVSHLDVLKTGKAMKKRKKFLRHRFWHEVAAGAKLICLSPMVRGMYRPTDVLGLHRLLICVEPKIQAWRNTHSCVVIDRMEDITDPDVVANNPLHSRTVAFYGYARGKPMKPGQLVHIPGLGDFPVVHLSHQADPCQLDKFSRDSKEGGNHRMRHLSLKQKKLYAPYCDIGGISYDEDAIYIQEDAAKEAIERSGEGLRLLQELKNAQPINAAQTKLRVVPHRRRPMNFRDDDTMELDMEEVRMPSDADDDDWSDDAGAKDGCSNIVIDSDDDSGKRERQQRGIPRLSDFGVPEDGGDEAAIGGSDDDDEGSGEATLAPRLLNDPDSIRLNVIRHDWSDASLLRSLKDLCVTGNWEASAQGGDEEDANAVEEGSKGYDTSDEDFELEARGEKPMTCHGNGRIGAAAVAGFSTNGSDGDGESENRDDDFGFGEDRKSTHGTAAAPVRRNALASIGYGRSSSCGGRGSPRWGEGADVDDEYNGYNVLDDDSDGGEVAANGKAGRSVLGGTDSELEGLVSTFLTHGTSRNGNRSSRGSELTAAKAGFDGEDGIEFFDEATRYNRDDDGEDDRPRPRRRHVNPQEERNADEEAGAEAAVRQGGSLTAEQERLLLKKMAKKRAFNDEYDTGDADGGKNTTFSYYHQLNRQVEEKKERISEALDDVGDDIEKKIQLVGYFSGLYLRIVIDNVPVEFFKAFDPAIPLLAGGVNAGEDEFCIVQARLKRHRWFPRILKAQNPLLLSMGWRRFQTQPIFATDDPNGRHRYLKYTPLHMHCMAAFYAPVAPPNTGFLAIPVRDPRVSSFRIPCTGYTIGNDVSTSIVKKLKLTGTPAKVEKTTAFIKGMFSSDVEATKFIGAKLKAVSGIRGIIKSVMKGKQGLVRATFEDKLFPSDIVFIRAWKSVEPPRYCSMQRNLVDPEWVGMRSMRELRLDYNVPLPRNDDSEYTAIKRRHRVAEEDEDLTKQKVLLSRNLKLQLPYDMKEDFIPVNRDTALQERIKGATTVAPEPREQRRQALLDTFTDRADAMEQKKDAAKKRARDRSAKKAVKEQEEYLQGLKKAKKDTARMREFRTQHKSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUK3</accession>
    <name>A0A088RUK3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL23m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_250910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699661.1">
        <property type="nucleotide sequence ID" value="XM_010701359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUK3"/>
    <dbReference type="GeneID" id="22575739"/>
    <dbReference type="KEGG" id="lpan:LPMP_250910"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250015100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_250910"/>
    <dbReference type="eggNOG" id="ENOG502RFBU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275582at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000852">
        <property type="entry name" value="Ribosomal protein L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL23M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059">
        <property type="entry name" value="RIBOSOMAL PROTEIN L23-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN98954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="256" mass="29433" checksum="E42FEBFC8FE23330" modified="2014-11-26" version="1">MKHLSSPHAISCIVARVTTAIAASRTRSSDVVGGSSSSTATSSLLTAKRGRFYRPLVNQGINLWRSRMGRLHKGWTTWEYDHNVIPDPRPFPEPAVNNYYGRSRIWNPIAGKIGVVNRKAEEWGWPHQRPPHTGLRRSPEYFPYFFSRYFPDVEVRLVLDSVLNNETTRPIFHIPQDMSKQELVNYLKNIYNIDNVVRIRVRNMRGRRFKNEVGEIKSLPDYKMAVVELDSPVSIVFKQIKGTEDTPDNKPQAQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUV2</accession>
    <name>A0A088RUV2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-alanine--D-alanine ligase, putative</fullName>
            <ecNumber evidence="4">2.1.1.354</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_251860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.354" evidence="4"/>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699756.1">
        <property type="nucleotide sequence ID" value="XM_010701454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUV2"/>
    <dbReference type="GeneID" id="22575834"/>
    <dbReference type="KEGG" id="lpan:LPMP_251860"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250020700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_251860"/>
    <dbReference type="eggNOG" id="ENOG502RFSY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000112">
        <property type="entry name" value="ATP-grasp domain containing protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000078">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23132">
        <property type="entry name" value="D-ALANINE--D-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23132:SF23">
        <property type="entry name" value="D-ALANINE--D-ALANINE LIGASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="D-alanine--D-alanine ligase C-terminal" evidence="3">
        <location>
            <begin position="419"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="707"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="803"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="810"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="828"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN99049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="861" mass="91946" checksum="E87638FEE8D989B2" modified="2014-11-26" version="1">MISRGNTGTSRWAAGVLRCLHYSPNAAVILALTALQSPCRVRVLDHWMGNAARTPLVASAALVFQQRFYVSTGATGCNGVSHGHDHRFSESKNGVAGSSGSSSANSGACGSGGSGFRGSGATSREQQATKRTKKVKASRRLLKSKRTGPKAKSTSTPRSSASGSSAATMSANATSGSASVNQGGAAGSSGSGSGGGPGSSPSSSPAAASAQPRSVTCRRKKKSSRAPSSPSATPLTPGSDAAARRPKRSLTRKRVQTGSFSNGSATVKKSTSAAHATSPARPASAALPATAAVRAKSKKRKRIRICVLSSSYDGTDSATASVDNYWCTPQHYMKKDRHKYSFADVSMKKIDSYRTVRKLVTSNKYDVFFNLCDGGRDEKRAGVDVVEALEEQNAAFTGTDSRGFEPSKIDMKLMVGSSGVKVPNFVLLNDEESLAKKCRHLKFPVIVKHLSGYASVGIHKENRCDTLDQLRTRVRGFIKEYNHALVEEFIRGREGTVLACADPGSPFGVKVFKPLMFSFLQSSDDFAYFEKKWTMECGDQAYGFLASSDPAYPAITEMARNAFKYIMNGVGYGRVDFRIDELTGAPYFLEINPNCGMWYAPKDGGDFADVMVEGDPHWNHERFVANAVARALRDQAARKPWYFISHDRNGQFTTRASKTVAAGKCLFGDAVHPIPVVAKSLYKLGEEEPTVGCVICRGDGIHQAVALRHSCEPNMSFVHGRTLLFAAKRPINVGEELTVDYATLRDESMPHFVCSCGTENCRSVIFPMPAMPRTVEAKAMKRLLREKKQVWMKEKADREVERILKKRSSRASSSAPSGSISSGGGASAGSSSNTGHASSSASGSASSSSGSSGGINALERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVC1</accession>
    <name>A0A088RVC1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_291490</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Clathrin-coated vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700755.1">
        <property type="nucleotide sequence ID" value="XM_010702453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVC1"/>
    <dbReference type="GeneID" id="22576912"/>
    <dbReference type="KEGG" id="lpan:LPMP_291490"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290018900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_291490"/>
    <dbReference type="eggNOG" id="KOG0934">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016482">
        <property type="term" value="P:cytosolic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14831">
        <property type="entry name" value="AP1_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000007">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044733">
        <property type="entry name" value="AP1_sigma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="10">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIO00098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="165" mass="19013" checksum="1671673A53E96450" modified="2014-11-26" version="1">MIQFLLLMSRQGKIRLSKWYVTLSQKEQAKIIREVSQAALGRSSRLSNMFEIEGRKYVCRRYASLYFIVCVDKTDNELITLEIIHHFVEVLDQYFGNVCELDLIFNFHRAYFILDEVLLGGELQLSNKRGILAYIDRLDAAAERSEARLEGGSLVDQMTNAIKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVD8</accession>
    <name>A0A088RVD8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleoside triphosphate hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_260900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699911.1">
        <property type="nucleotide sequence ID" value="XM_010701609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVD8"/>
    <dbReference type="GeneID" id="22575993"/>
    <dbReference type="KEGG" id="lpan:LPMP_260900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260013700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_260900"/>
    <dbReference type="eggNOG" id="KOG0987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="242938at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="691" mass="77565" checksum="92075EE568C5AE27" modified="2014-11-26" version="1">MFQRSLSRFFAHLVREVDTAGFAGDFRCLRHIGAPSTQAKAREARNAGCNVLFCGHHGTGKLNLLKAIGLQCEKKGQRVAFVSADNQRAARLDGFLINFFIGMRVSRDELPSQEQLEGTLERHVRLVESTFASSLPSLCNVDVLILDALERVQPTVLLSMDAVARRLRGQPNAPFGGLRVYAAADFWRLPVHPTSDTGGYLFQLEQWETLFPLQTLLNTSHVQKEKELRRLTELAFYGALTLPHMKELEELSMKEKAESRLFSWSSSTAEAEKGAVTSGEGNSEGGEIEEEDAMSIAQWTRYVDEAAPTALDGSGEALKATKDNVVEADDPVAGLASPSSSSSSSSALALLNDDMASNSFVATRMMLRFPRQPAVKEMPPRYRQLKRTEMGNFLVNMLVHSSSAASLGLVDALSVDVGSRVHLLLDGQEHYGVPGGAVGEVMQVRPHFLSIHFPREHRTVDIPRMRVVCYHPFYPEIRYELQQFPVFPRKRVCPMNIIAFPHTFFVNLNGRRMADTNDLGNLLAHQRSFADFTIRSTSDFANLDGMVHEPTRIYYHKISKKPISAAKEQWCRNCKQFVSTSSFFEHWTACVHSVRWCCDCNQTVPLELLGPHREKHQVVLCLDCGRPVEWRHWEAHRLSCGPMMREVSTDNQFIPLRTRQLALEMGLDKRDLHTVTSITKSCLPKPKEGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVM1</accession>
    <name>A0A088RVM1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein serine/threonine kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_262020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700021.1">
        <property type="nucleotide sequence ID" value="XM_010701719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVM1"/>
    <dbReference type="GeneID" id="22576105"/>
    <dbReference type="KEGG" id="lpan:LPMP_262020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260024900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_262020"/>
    <dbReference type="eggNOG" id="ENOG502RZM4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053235">
        <property type="entry name" value="Ser_Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361">
        <property type="entry name" value="MITOGEN-ACTIVATED KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="904"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="529"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="682"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="988"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="689"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="988"/>
            <end position="1004"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1095" mass="118573" checksum="C27185559787ED7B" modified="2014-11-26" version="1">MGCYSSKARYGPLYRPEGGGVNVQQNEPLPSGNRDRVADKPNVVGVNSGGGGAKEKNNAKPARGGIPPYRPDETTAKGYHEYVMEVRRVAVAQGILPSVTDDAQLAVNSTLKRKGGFSWIKAENGRGLQRGGNPDAVAHPGASCVSPSVRTLTVYQCQPLDVDTAVAMGMYSTVYLARLSVFTGTSEAAVNATVPRYTPARKDNSGGTGGRSRYPIRVSGEVSSVKGLHSNTVDASSAHGTNTIAEPVSAPAAASTASPACTAVSHYIIAMKEITLGTRFATRPVLQQICLEVRRWTRLSTYCLRIVRCYQLEYVFPEGVSMPVLEASYHFFPGREHAYGSGGAATDGLFTFNSSVTGAASHSVDNRKRLARSDMLLVANSANQHSNFKANPLPLMATSGTPYKLRLYLEYAKHGTLRGFQMNEMQKRFGQRRLHELTARAYMRDVLLALLQLHERDEMQYDLCANAVFLHKPIQRVYYTYFPAYISDVPTGDLTRVTQSELSKALMSLDPSPPVEGAGLKQKTLCNEPINGTGPPPPGDYHGGSGEQWSRPFVAQPGTSAVGVETRFTQMISFLMQDGRRPPVTSTTGASPARNNNTSGKLDRVAVKPYEQRNGKKGPVANGGRTNEGHSRAPFCSTPPEASLFGSSSRIVSAGGSFRKNQVFSDRTPNARRGRNYFLAGRGARPQVKQRSANNERATASSEVDGDDTQHSHLHGTYCRLMDTFEFMCLDEDQNLPFPSPHDGVGAQTDAEMVVSTMLPEELREALPMRVLPLQHTSLGGIAILSPDCYVVKPIETPLPDLRGRLPILLPSSTSYGAFRGGPQLQQVMHRPPISAAPGLSGSFSTGQSFAPQILSAGTTASNAAGALGRYRGGTPLVKLNHSSLVRRALCFADSNKLEEVPVHKYVTATHAAPEVLHSRLFSPASDIYAFAMTFIELVSDDGAIMKDCLPTHLPKPVTPHDKEAYDALLAENLDKWYQDQIKALPQNKTSVSRDQGQQDSVSPRTGPIVMHLPPHLSDECKKILRWCLQPDPTKRPTAAELLRSRYFMLGDWIAAPSAVAAEGKTTQLPEAPWTTSVGFDVAAKVAGLPVLNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVU6</accession>
    <name>A0A088RVU6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_270140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700101.1">
        <property type="nucleotide sequence ID" value="XM_010701799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVU6"/>
    <dbReference type="GeneID" id="22576190"/>
    <dbReference type="KEGG" id="lpan:LPMP_270140"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270006900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_270140"/>
    <dbReference type="eggNOG" id="ENOG502SJPP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272892at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="243" mass="27009" checksum="9F869F52A8B0446C" modified="2014-11-26" version="1">MSAPRGERVAMAGDTNRSFTSSPPDDILSELTSHVSRSAITSYGARMPKESAESVLLRRRMEVMKTAAAIHANEDIFGGAHVSKHVRALPQMKPARRDKTCKPLYPTTFTNRYKTIADLKAEDGTQQAAGQLQRSSLVRDASGSLVPTESLHGIAITGSDPRQAVTEKYRAALVTYRQHVFTRIEHSIMSFSHSLGAVKPYAMSRAAKLGTRHCFADLPHDTNDRYVDRMQCYRPSKGLYTYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RW48</accession>
    <name>A0A088RW48_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Intraciliary transport protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_292770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IFT56 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700881.1">
        <property type="nucleotide sequence ID" value="XM_010702579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RW48"/>
    <dbReference type="GeneID" id="22577040"/>
    <dbReference type="KEGG" id="lpan:LPMP_292770"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290030800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_292770"/>
    <dbReference type="eggNOG" id="KOG3785">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="95390at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097546">
        <property type="term" value="C:ciliary base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120170">
        <property type="term" value="F:intraciliary transport particle B binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035720">
        <property type="term" value="P:intraciliary anterograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035735">
        <property type="term" value="P:intraciliary transport involved in cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030511">
        <property type="entry name" value="TTC26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14781">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14781:SF0">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO00224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="568" mass="64784" checksum="8CE3EA8150C45FA7" modified="2014-11-26" version="1">MITTSGRVVRKGGNASSTRMAPPPKQTPQEQIEDALQARDFSKATTILEFYKTSGQSLGDFAINEWLAYSAFHANDIEKAIDVYKEILALEDSAPINHTYLGCCYYMNGSFKEAEECALRGPTCPLQTRLMLHIAQKMHNEEKLMVYHGKLQDTVEDQLSLAAAQYIRNHYTEAIEAYKPILAQMREYKALNVYVAMCYFKLDYYEVSVSVLNVYLQTYTSSAVAINLKAANHYRLFNNRAAKSELKLLIDLQRTTYYVETDIVKHNLVVFNNGEGALQVLPSLLDVGIPEARLNLVIYHLRHECINEAYELMADVDPLTTQEYILKAVVNAYMGQNMESQEHLKVCREIFNYVGSSASDRDTIPGRQCMASYFFLLRDFPNVLIYLRSIKPYFSKDDTFLYLYGIACAGTGEYAEAEQSLLAVSSEKIKSEFSYTSWLVRSHINNKHPKMAWDIYLKKEMGESIGILRLLANDCYRTSAFYYAAKAFDVLERLDNEPEYVEGKKGACIGVFQQVFANEEPADSLFDVMKLIDASLQRHVDDQPTVQQFSSMLALMKDWAKDAKLKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWE0</accession>
    <name>A0A088RWE0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">START domain-containing protein 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">PCTP-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">StAR-related lipid transfer protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">LPMP_292740</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700878.1">
        <property type="nucleotide sequence ID" value="XM_010702576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWE0"/>
    <dbReference type="GeneID" id="22577037"/>
    <dbReference type="KEGG" id="lpan:LPMP_292740"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290030500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_292740"/>
    <dbReference type="eggNOG" id="KOG2761">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5403181at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08871">
        <property type="entry name" value="START_STARD10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000008">
        <property type="entry name" value="START domain containing 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041951">
        <property type="entry name" value="STARD10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051213">
        <property type="entry name" value="START_lipid_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308">
        <property type="entry name" value="PHOSPHATIDYLCHOLINE TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308:SF51">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00234">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="9" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="11" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="START" evidence="18">
        <location>
            <begin position="9"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="254"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00070345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00076937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00080073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AIO00221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="366" mass="41710" checksum="8548BFB556F2EDE7" modified="2014-11-26" version="1">MESSEERYAECKGTRYVLMTLPHFRKVRKLALSRDASWKTQYSDSQLTVESKPPEDASTHLNIIRATRIMKKVPPLVLYNQLHDAQYRTTWDTNMLDGYNIVQLDKHNDIGYYAAKFPWPLSNRDFCNMRSWMEFTNGEYMIFNHSEPHPDCPVKKGFVRARSILTGFYIRPIPGESGTQLIYVTQSDPCGSIPHSVINYAMTKGARMILDNCEKYSERYPAYTEKTYSVDHVYPWRTPKMDWDSTYLYPEDVPASSGPAVEHQQLDAHGGGGDGEEGNGKSGEKMASPFLSSAVTPFSTSLALAPVAPYCITDLLSVQQYRSIMQDAMNAVDRSFLREGRVPTTKEYILRLKYIIEGIRQTTVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWE1</accession>
    <name>A0A088RWE1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_271950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700281.1">
        <property type="nucleotide sequence ID" value="XM_010701979.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22576373"/>
    <dbReference type="KEGG" id="lpan:LPMP_271950"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270027800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_271950"/>
    <dbReference type="eggNOG" id="KOG3078">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262413at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22967">
        <property type="entry name" value="DD_AK7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047499">
        <property type="entry name" value="DD_AK7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="590"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="658"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="699"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="819"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="986"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1106"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="592"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="615"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="711"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="836"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="855"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="995"/>
            <end position="1004"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1511" mass="163077" checksum="F9D2347D6D94A6CA" modified="2014-11-26" version="1">MKKVLVLNGDSYVGRHVVKAFYQSYEYDVEITLTRTGERAAATTRTVSKATSSDWLWDQMKSLWDSLERSLVAAAADNSDDPSTASTPGSHCRSKKRATSAVGTEELPTSPPLAGLSAEEQDMLPADLQFCVRSIVPKHNDNAEEFRKRLLANDVVIAVLQDDTYEAMCAIRILAGTHYEVEKTFVLVSSAVTWAYTLTSERARAREMRQREREEERSAFLEELLNAEDEDIGDEDDLSEGAAAMAEREARRAARRTELERRLPFSLREPAAGEDEAEIHALVPDRVFTDDAYAQRVPHPRFQHWHSLEHLVKCANTETLHTYVVFAGLPYGAGEGSDMLFGLLRSAWYHQVLPQYGAGVNRIPMIHVQDLASVLYKVGSAYDVLDKRYVFAVDQGHVTQRQLLHAVQARFGGFVQPAVAVSLPLTAADLVCLDGLELPPPTSPQDLFATFGNESCWGDGGALLTALVLSDIQAEPSTALTVHVEEEWVSLDGFLANLDVVCAQFRAAHAEMFKPVRALITGPPLSGAETVAALLAQHCRVPCVSRESIVVDYKAHMADVRAALRGLLMRRLQRRRARMQARLVRQAAQEKVAQHLAKEEQRRQRREDRQQRGDTDDDSGSEEERDEEGSAADEEGEGIDAASEVDSRASLMSIFLPPATKSADDGNEDEEGAVQQWWQPPLRPIELVVNEAYIRGAADAGVGDGDHEDSAEIDEEQEEGGEEDDKEGGGNWLAQLDAQDEEAQAEMEEDRELLPPVPLSAAMGDRVLPSLALPRFAARSRGRAFARDVDRQELRCIAALRQEYLLGLKVLALKVSTEGRLPRPLPTPAVTEDGVNDGGYGDEVGRGGTSNGTDGEGDEEDEEDEEDEEADGEAPSDGEPHASLEGSNNGAEEEDEDTDYGRAGTINEANPILAIDPDEDDSVYLDCALAFMCRWRLRQSDCRCQGYILSDFPQTLAQAILCFRANETELEDGELRRQRALAPLLTRTDDHAAEDNSDADDEDGGPLAPIDADFPLPDIASIKEEELLALERAHRRGRGPACSGSAAGEVESMGDLTEEAAAASSDVETVMTPVDESLFVDYVVALQADPAFLRATIDALQTKLDAAADRRPSSTSPRDAAPSAHSAAAIGLSEAALATLRDSLHITPYAAQLEWYMKHHAATASPIQSLLAWLSAITTTPALGVRSAQVIVPPSNNDDVADAEGAGGVAPTTMEAPPTTRTAQMLFMSVPVLNTEEVKACWCAARERKARADARAATVGMATRTMPNRTCGDECGSALVNAMLPVALMRLAPLCWTGAAAPKSAALLSQAPSSSAHTPHPRDSLAASRCALQPAASLEALAQELCTRIAPARRNPTAVATAAALPAACVTADRASYTSTETTSPLALNATATAAAPASQVDVIGVSEAPADASASDAAAAAAERKARLAAASQDEASQILHELASLRHLQIVEGSPETAEMLGLPAETYLMRYVLPNLTPVMTGVVRMRSNDPVSTLADALFDHCRRVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWR9</accession>
    <name>A0A088RWR9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Rrp44p-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_280330</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700376.1">
        <property type="nucleotide sequence ID" value="XM_010702074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWR9"/>
    <dbReference type="GeneID" id="22576478"/>
    <dbReference type="KEGG" id="lpan:LPMP_280330"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280008700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_280330"/>
    <dbReference type="eggNOG" id="KOG2102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="372421at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000007">
        <property type="entry name" value="Putative rrp44p homologue"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.690:FF:000010">
        <property type="entry name" value="Rrp44p homologue, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033771">
        <property type="entry name" value="Rrp44_CSD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF35">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RRP44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17216">
        <property type="entry name" value="Rrp44_CSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="RNB" evidence="10">
        <location>
            <begin position="397"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN99669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="920" mass="103523" checksum="EB237F441C9B88F3" modified="2014-11-26" version="1">MNAMEDRRVQNIILLTTVMSEVQNRNKAMYARLQLLLGDKKKQCFVFANDRHEQTHCMRKEGESPNDFNDRAIRVAAQWYARHVVAAFPGTADLSTSGVIVVSHDQAFKQAMNASEEAQRVSNLRCVSLRDYIKLNVASDSDLLEKIQAEEPEGMKESPSTRQLFTPYLSMTALDAGVQDGSLYKGKLRVSETSCFFGEIRGKFERHNFQRILIQGRANMNRAIHDDIVAVQLLPVSSWRGPKGSAPLSESVSEDDAIAARFSPAGKVVGLLSSNRRPFCGSLDETELERVKANKSGNVSILFQPKNNRIPRIRISTRHVQDLMDKRLSVVIDDWPLYSSFPVGHYVEVLGKIGDRDTEATVILLENDVPHYDFSEAVHDCLPKGQWAVTKDEEAKRLDLRDLCIVSVDPLGCRDIDDALHCRAVNGNHLEVGVHIADVTHFLPGGTAMDEEAAKRSTSVYLVDRRINMLPQLLTENLCSLVEAEDRYAFSILWEFDENLNVVRDWFGKTIIRSRGALYYGDAQRMIDNPADTSDIAVSLRELMRLSKHFKAHREKDGALFLASQEFKFKVDNEHVNPTDMQMYQTFEANSMIEEWMLYANAAVATKVYESYPQWALLRRHERPAEGAFDTLNDALFGKLHVRLDDTTSLTLNTSLDKCEDPRDPYFNRLIRILTTRCLRQAQYFSSGGIPKDEFCHFGLAMPIYTHFTSPIRRYADVIVHRQLAAAIGVASVSEEQMNAGRMKTIAENLNYRHEQAQRAGRDSQNLFTGFYLRNFEDGKIPDEEGYVVRVSETHVFVLVPKYGQESRIPREQLQTVPGLLDKVKVGIQLKRQGDVMRTKLVFRLIGMMRDGEEGGVLVADDEAYDIIEDGEEAAEDAQKAARGTSRACVAAGGSGIEALEPGLKRAKAEGVETALPTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RX09</accession>
    <name>A0A088RX09_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="19">ATP-dependent zinc metallopeptidase, putative</fullName>
            <ecNumber evidence="19">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">LPMP_310690</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="19"/>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701458.1">
        <property type="nucleotide sequence ID" value="XM_010703156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RX09"/>
    <dbReference type="GeneID" id="22577495"/>
    <dbReference type="KEGG" id="lpan:LPMP_310690"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310012100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_310690"/>
    <dbReference type="eggNOG" id="KOG0731">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005745">
        <property type="term" value="C:m-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000003">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000982">
        <property type="entry name" value="Inactive ATP-dependent zinc metalloprotease FTSHI 2 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000147">
        <property type="entry name" value="Putative ATP-dependent zinc metallopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050928">
        <property type="entry name" value="ATP-dep_Zn_Metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655:SF2">
        <property type="entry name" value="AFG3 LIKE MATRIX AAA PEPTIDASE SUBUNIT 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="319"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="502"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="517"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AIO00658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="838" mass="92098" checksum="41C0000301C6A940" modified="2014-11-26" version="1">MATIRRLSYADRLHRHLRVPPHLEDSQKLDALLHTLCRRPTRSVSSTACHRWGVLLSKSNDSKGSGGSGRDSSRGEDDGAGEEGEDKPEDWIVPRTCLFVITMIAITAVLYQLAQPSGTHTGWASLNKHAGEIKAAVLYDNYLQVYMDDAKVYLGLLNDQDTQRHMDELADNYRAARLQAVETQQRQSEKTHTDDEEQEHGNKLPTAVDRPVELEVTRKGRPYAETALVGVGAFAWVVPFIFFPVFVMFLSQYIGKSMSYAVEATKGRTKTKEMAFRVETASNTRFRDIAGMREPKKEITEIVDFLRHPERYTKLGAKIPTGAILLGPPGTGKTLLAKAVAGESGVGFIPAIGSDFVELYVGMGALRVRQLFKEARKQRCIVYIDEIDAIGLKRQGAGHGEKQEQEQTLNELLTQLDGFSTGRRGDVMVLASSNVAQEVLDPALIRPGRFDRIIHVDTPVISERIDIFKVHLSKLKLTSDDAHGDSAAATTATAAAAEGDAAGVGASAEPPLAVPASTETSLVLSQVKTEKECETEEEDAEKSGSSAAVPREAKRIPSGTHSSSAHEFDFRSLLMQKSERERALIDAYAQRMSNLCPGFVGADIANVCNEAAILAARERAHHVDISHLERSIDRVLAGIEHRSRALSDFEKNVVAHHEAGHAVAGWFLNRADPLMKVSIVPRGGSALGYAQYLPNENFTRTAKEIRDSISVTLGGRAAEEIFFNHLSTGASDDLRKVGRLAYQYISSFAPGSVYPPPGSSSTRLVKPFGVDKANDFDRRAKKVVDEVYADTLALLTKHKDDMKKLADHLLKHELLTYADVVHYLGERTTRQSDKKKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXS4</accession>
    <name>A0A088RXS4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_311260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701516.1">
        <property type="nucleotide sequence ID" value="XM_010703214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXS4"/>
    <dbReference type="GeneID" id="22577552"/>
    <dbReference type="KEGG" id="lpan:LPMP_311260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310014400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_311260"/>
    <dbReference type="eggNOG" id="ENOG502S8Z2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266282at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="2">
        <location>
            <begin position="331"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="525" mass="55377" checksum="0AA8478241095385" modified="2014-11-26" version="1">MFYTFCSSPVGVVPTWNNMSAGLQPLSPQLPYRLRNQVIQGYPATLNNGLSVMYYAPVVNKVSQQQVSYFPMAAQRWSFASASGAAQPATEVCNSMCFAPCESGANVSSNRSPLMLQSLIEMPSFMADKQHLHSLESQPSPMLSRLTRGLCSTGEVTKTFGASTTSVTSSNVGSGTSNGISTTTNGSMTPMGASSAAPGFQMTVPRPTSAMTSVAALPQQPQACFLANHTTGALTLIRAEDVTVSDADTTTSTHSYAMQPQLSMPSQSASASATSVPAYLVAPQVPSFGGTMASNFSKPFPGSTPLAVPALPSPPQPAKTLNGLYYQLGEVYEGFVKRYNPNRGFGFLTATTHVTVSANGDSATGTPPTSLSAPATAVPPTEEAEAPEKRRTPVHLGDIFVHQSSMQMEGFRALPVGGRVRFRIGYKDGQQTLQAVDVELLPQVCPLNVEMALSATPVQQAKTAVLDEMTDTVTSVPGVVQPAICASRSAASEQRSEGCALSYTSSEGDEPLIELAYDMYSSFEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYF8</accession>
    <name>A0A088RYF8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyridine nucleotide-disulfide oxidoreductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_320990</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO00986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701786.1">
        <property type="nucleotide sequence ID" value="XM_010703484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYF8"/>
    <dbReference type="GeneID" id="22577840"/>
    <dbReference type="KEGG" id="lpan:LPMP_320990"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320015000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_320990"/>
    <dbReference type="eggNOG" id="ENOG502RQXD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051473">
        <property type="entry name" value="P2Ox-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42784">
        <property type="entry name" value="PYRANOSE 2-OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42784:SF1">
        <property type="entry name" value="PYRANOSE 2-OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839131" evidence="6">
        <location>
            <begin position="18"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO00986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="704" mass="76211" checksum="FAAB3DF1EB33F61B" modified="2014-11-26" version="1">MFVELAIVVAMLLVCWYRSFRPRSTNQLRPSYQSHCSTAGLCAGDYVVIGGGVAGLAAAAELLRRTDETCQIILIESGNDPQSASAAALLFEVGRRDRLLSFAPDLVRVPQELLLKGVRPTFLGGTPDVGYLAQRPWHYFQDEEVLLGTSSSGSGETLSAAKAKANRYRQLQYAAYPRGVGLGGTALLDWGIHLNSLWPSTPEAVPDAEKATFKSAMTCNEALLQWTRLPMRFPDVRNPLSWAFAEAVKTLKLAAPYLPSVSAPVKRGAVFPCYLYLDEDGRRLALPSAVLGDIAADELHRRLSVLTGYTAVDLDLAAQDGGEAEERGVRVIGVQVRLSRGGAGAVISIPVRKGVVVAAGALHSPRLLHRMSRYRAMRMLKPPSSTVPVRDALALPLIFSAVQAVSADSLNVRDAKSSAIWWLTQRGPYLTPLCDTVLSLPLPHIGPQAELRVVLFPFGGRDAARFKGMGWDIVLGTPLQAFTMLLIFHGIDGLEHMMTLDEEAPQPGVAHTRALCSHQTVCSLSEEVHRKVQDGFLAGIKECRRLTEAEPLASLALTPGFESTDFTLLVPSDASKAVRLAQLSRLPPSKRSARGKAELKQLLEWSHRVTATEWYMRRYVDTHAYWLGFASGSSEAFLASSSSTPCSSRVAGLQNVFVGDSSAVTTAHWSGVGKRDTLAAGSRSTCMDAAVRAVTELVKIRGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYQ7</accession>
    <name>A0A088RYQ7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-hydroxyisobutyryl-CoA hydrolase</fullName>
            <ecNumber evidence="2">3.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_323810</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20888"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57340"/>
            <dbReference type="EC" id="3.1.2.4"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.2.4" evidence="2"/>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702063.1">
        <property type="nucleotide sequence ID" value="XM_010703761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYQ7"/>
    <dbReference type="GeneID" id="22578122"/>
    <dbReference type="KEGG" id="lpan:LPMP_323810"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320045200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_323810"/>
    <dbReference type="eggNOG" id="KOG1684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1737613at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004127">
        <property type="entry name" value="PRK05617.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176:SF3">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="4">
        <location>
            <begin position="22"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO01263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="376" mass="40674" checksum="4D15D3E5886E446E" modified="2014-11-26" version="1">MMRHTAARCSAAVLCTDYPHARLITLNKPKSLNALDYDMTQELHRLYVTAPAPLSSLYILTGAGTKAFCAGGDVIGLTTNTPPGCGRDFFYEEYQVDYKTSILPAGQVCLWDGYVLGGGVGVSVGGTYRVASEKACLAMPEVAIGMFPDVGASWFLPRLSVPGLGLYMGLTGHRLRGADLVHLGLATHFVPSAKMDDLKHALVSMSKAGDVEAALEKYATPTAQLPPCTIAHSFPSLAQYFDITEDLTILSILDACKTHAHTDPLIKAAADFMPTFSPTAMTLTLEMLKRGAKLSTPVEAFKMEYCVSQRVIAAHDFREGVRALLIDKEKGPKWQPATFAEVTAEAIDAYFRPTTPDQLVWDPVAPLPERALCDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZ11</accession>
    <name>A0A088RZ11_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH dehydrogenase subunit NI8M, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_323350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702019.1">
        <property type="nucleotide sequence ID" value="XM_010703717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZ11"/>
    <dbReference type="GeneID" id="22578076"/>
    <dbReference type="KEGG" id="lpan:LPMP_323350"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320040000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_323350"/>
    <dbReference type="eggNOG" id="ENOG502QUSA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268513at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016464">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12878:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12878">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B8 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="165" mass="18747" checksum="41D2B892661F6DA5" modified="2014-11-26" version="1">MSWRARFTPCVGSLTVWLNPKDPNCFGVRNWWRNNLPELQLLNPFCTFTIQELSFGEPHMYINYTPTDQRMIRLAGATEEEFEEIMEACITYGMNHAIIERPRTDDGGDLVNQPAITSFGYTESFTAKLEVAPPADIGQKTTEGVDDPGQKPRLYPRNVGCKLMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZ28</accession>
    <name>A0A088RZ28_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_322760</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701961.1">
        <property type="nucleotide sequence ID" value="XM_010703659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZ28"/>
    <dbReference type="GeneID" id="22578017"/>
    <dbReference type="KEGG" id="lpan:LPMP_322760"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320033800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_322760"/>
    <dbReference type="eggNOG" id="ENOG502RFT9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="13598at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033034">
        <property type="entry name" value="NDUFB9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B22 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIO01161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="301" mass="36000" checksum="000B5B8B00B46021" modified="2014-11-26" version="1">MRRSSLLLSGGMVEYHEWHLHEPLLQNYEGWRILDNPKYEQKSDAYIHDFMGSVRHLDPIIDDPRLTHKQRVCRLYRWSLKEIQMWLIQLNAHKFNLAYKVIRRRFEKYRYVTDPATCDMMVRQTQKYLRDNANFHYMRRNNSSPWGTYTLANPMFHPDNSLVYDHWTHPEVMWYDDAKLHRWTAHHPMYAGPGEASERFGDMDVAPHLCGLVWAIFMSLFAWCFYQLLGGPELRGDRHFEEWTMQFDENLAGALYAEERNSRSRSSVLRGDWDRIMGVASTLTDYYRNNMSVVDKTNYPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZG4</accession>
    <name>A0A088RZG4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">D-xylulose reductase, putative</fullName>
            <ecNumber evidence="8">1.1.1.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_330530</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.19" evidence="8"/>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702146.1">
        <property type="nucleotide sequence ID" value="XM_010703844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZG4"/>
    <dbReference type="GeneID" id="22578206"/>
    <dbReference type="KEGG" id="lpan:LPMP_330530"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330009900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_330530"/>
    <dbReference type="eggNOG" id="KOG0024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="256333at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047939">
        <property type="term" value="F:L-glucuronate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="12"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO01346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="349" mass="37632" checksum="278478B957E02104" modified="2014-11-26" version="1">MVLMQSLVLERKSELAIREVDVCDELGPHDCRVKIHSVGICGSDVHYYEHGRIGPFVVEKPMILGHEASGTVVAVGTDVKELKAGDRVALEPGIPRWDSAQTLSGLYNLDPELTFFATPPVHGCMSTTIIHPAALCFKLPDNVSYEEGALCEPIAVGMHSVTKAGVKPGDVGLVIGCGTIGIMTALSALTGGCSEVIVCGSHDARLEITHRYPGLRAVNTSRADELKRVVAEATEGKGCDVIFECGGAASAFPLIYEHAAPGATCVLVGMPIEPVPFDVVMAQAKEITFQTVFRYRNVYPRIIRLLSSGKMDVKPLISATFAFKDSVKAYERAMNRDPKDMKIMIQMDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZS4</accession>
    <name>A0A088RZS4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pseudouridine synthase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_331690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01461.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702261.1">
        <property type="nucleotide sequence ID" value="XM_010703959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZS4"/>
    <dbReference type="GeneID" id="22578322"/>
    <dbReference type="KEGG" id="lpan:LPMP_331690"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330023600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_331690"/>
    <dbReference type="eggNOG" id="ENOG502RY89">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272717at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326:SF28">
        <property type="entry name" value="TRUD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO01461.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="900" mass="97930" checksum="0A30C70486C29A52" modified="2026-01-28" version="2">MKCTTRWCDTGGVVAAMERAHRYMPKQTFVSRAPADGEAEYPHKPHYLIPDLQRYAERQQEHQHAHKQPLSDLAQLNEPAMSTPTVTSATLAYFIQTAKNAFKRSLASFQHQALASQPATRSAATCTATWMPQSPVGLTGGASRYELEAAVRGYNPTVDRALLQQIAARLAIANTLRMARQLARYLHESAAAARDWKNSSNDDEHQVTAAQAVALLRRAADVCRAHYVQNSADMHTTSRPMSPSLWALTSAARESAGIATRLHYSSAATTRHAHRRRRQPPRCFLRYTSDVQVNEVLPNGAVVTFTHATRPEEVGYRAAPAKGKGREGGPGTFAAAAEARRGLPYFSASVSFRESLESCLTSCPSSVYLHFVLYRHGVSLAAAIADIVKASEGLISAHDVCVSIHMPENDEHVAVQTCSIRMALPMSTQPLNVEDAVQHCMHTARVILQLNLAGGAPRVALQLLACHTDPCGEQHTVSRVLDESPTRLQYALLLRGFDQRGGPLNQLDHASLACATCVPNYFSPHHFGAAAVPFFRTYHVTEALAKRRYADAAVMMACLEVEAVAETNNEVPPWLERALQLLCCGEDREGVWQAWWIHEVPAAMRRRMVCAKSDLVWNVLASFRLRELAMATGGRRDVLLAAAPKPGDFVLQPEEARDGGARSEIPSPLARSASVTVVHNQAQAAHYSVHDIAVPLVLDTSSESVGCESLADIEAQLGFTSDHCHSSPLRRSQRSRQSHTSPSAVTQTNETAFRPLLIAATGYPRAARPWCRSFPEPPVGPVVGHPKTALECNATVFTLSTDLDLASQTAAARDYAAKSRGPRARVWPLSKRGRALTDRLPAGLMAVASADGSSLLSSASAANHHGSRCLAIHCTLPARLSLANFVSELAVVEDLRDSWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZT9</accession>
    <name>A0A088RZT9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Zinc transporter-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_312230</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701610.1">
        <property type="nucleotide sequence ID" value="XM_010703308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZT9"/>
    <dbReference type="GeneID" id="22577649"/>
    <dbReference type="KEGG" id="lpan:LPMP_312230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310029500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_312230"/>
    <dbReference type="eggNOG" id="KOG1482">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9944568at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050681">
        <property type="entry name" value="CDF/SLC30A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11562">
        <property type="entry name" value="CATION EFFLUX PROTEIN/ ZINC TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11562:SF17">
        <property type="entry name" value="RE54080P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0864">Zinc transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="11">
        <location>
            <begin position="62"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="12">
        <location>
            <begin position="343"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="212"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIO00810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="439" mass="46759" checksum="CB2531667C0891D2" modified="2014-11-26" version="1">MSAEQPGETTGLTVAIAGPSVANYHAASTPAYVTVAEERTIDEALSAVEARRESEKKVLLGALIFCFVFMLVEFTSGVMAHSLALLTDAIHLLADVGSYALSIGALVAAGRAACGRYSYGWHRAEVIGTLISVFSIWALVTWIVIEAGYRTYDIYMCSRVPAQVSAGVMSVRDCQAVDSRLMIVVGVLGMVVNVVCASILYFGGSHGHSHFGSSHGHSHGGSGEHNQDHIHEDDHDHGHDHDHDHDHGHATQSGGGIGSHKGFAVHAAILHAMGDCVQSIGVILAGIVIYLCNLAYYGKYTYEHSLFNLADPFCSVMFAVITLNMTKALLMDLFGILMESTPASVDYSALDAALRQIDGVVDVHDLHVWSLSAEYVSLSVHLVADDSADALHKAQHICSAHFGIRHTTIQVDPVAIGTAGCASACASPTVHDEVSSHYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZX7</accession>
    <name>A0A088RZX7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_332250</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702316.1">
        <property type="nucleotide sequence ID" value="XM_010704014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZX7"/>
    <dbReference type="GeneID" id="22578378"/>
    <dbReference type="KEGG" id="lpan:LPMP_332250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330030000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_332250"/>
    <dbReference type="eggNOG" id="KOG4280">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00106">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000124">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="2"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="579"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="689"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="756"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="901"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="689"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="765"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="831"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="901"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="73"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIO01516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="961" mass="106582" checksum="57DC4D3C8CCA26E2" modified="2014-11-26" version="1">MSIEVHVRIRPSVANVVWSSAETVLYSTANPNTRYVYNKVYPNNSTNESIFHGMEAVVHAAFDGKNVTVMAYGQTGSGKTHSMVGVDHDPGMVPRTAKLLLELKRTTPGAKIQAFYTEIYNESVKDLLEPQRGELALHDAPDGGVFFEKRMIDVETFDDFIQLQVAAERNRKYGVTNLNEHSSRSHVILTFEIQRHNRVGTSVLNLVDLAGSESASRANTVGVSLREGGHINRSLLTLGNVVDAIVERRPYVPYRDAKLTRLLRTCLGGSGITLILCCVNPSRENFDQTVATLRFTQRAMKIKNDPVVVLNMPPLFTHQYSNGARQLIEGLQESAEAEYQRGLRDSFLYCSSTVGSVVSNYQAQVSDCLHSLANAQRLLVAHDHAMAIDHIGRLYNQQNDLVRQRISNKELAENERKRQRNVASEIEFRKEKMTKLEDELSAKVSLLDTSLAGWEYQLYEARRKQRSEMDVLIQLELARRARLQYEWVVCFERIASCSVPLIQAGLLALQAKLVESGGGGSDTAECQQYRHLLPTILLSQECDTGHRTLHMKELRTTLMKARDELADLKMAHEMVKDDIEEARRQQQQQQQDSKRGTASVSPQPRPNLSDLSEEDLLEYYRGVADSEVEERIHRLEREEKALMAQARRGVRRESLRRVRESLRISCGSRGGSSRSPQSGAGGVTITRLTETAGTGPGSNASQRCGGTAANEEGRAGLRQMETSAQVEARDRRSSASYADGVKNALSILDSLKAQLQRKGGNNHLSSTVASTSRSQQAQSQRRQEVTHGRSNRSVSSSSERRRRQGRKGADKTAVYCDPEESNVGGLHQSVAPRSAAATAAHPCHHASASDNPADTENMSLAELYQASMGKENWSRTKFSTAAATLSRGAHKSTVVAEDDVTFDVDEEADGEEVRRPASDQPSSSPPVGIAARRRMKRQNSRPVVERALYALHSNSHSMSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZY6</accession>
    <name>A0A088RZY6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Proteophosphoglycan ppg4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_340470</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01673.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702473.1">
        <property type="nucleotide sequence ID" value="XM_010704171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZY6"/>
    <dbReference type="GeneID" id="22578551"/>
    <dbReference type="KEGG" id="lpan:LPMP_340470"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340009900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_340470"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="687555at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000041">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27000:SF642">
        <property type="entry name" value="INACTIVE LEUCINE-RICH REPEAT RECEPTOR KINASE XIAO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27000">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR-LIKE PROTEIN KINASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIO01673.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="16738" mass="1771446" checksum="C9C591C276C6EDFE" modified="2026-01-28" version="2">[encoded data, 16738 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0G1</accession>
    <name>A0A088S0G1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Oligosaccharyl transferase-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LPMP_341041</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endomembrane system</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01729.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702529.1">
        <property type="nucleotide sequence ID" value="XM_010704227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0G1"/>
    <dbReference type="GeneID" id="22578609"/>
    <dbReference type="KEGG" id="lpan:LPMP_341041"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340015700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_341041"/>
    <dbReference type="eggNOG" id="KOG2292">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261066at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004576">
        <property type="term" value="F:oligosaccharyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12610:FF:000003">
        <property type="entry name" value="Oligosaccharyl transferase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048999">
        <property type="entry name" value="STT3-PglB_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21436">
        <property type="entry name" value="STT3-PglB_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIO01729.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="773" mass="86071" checksum="0888162F51AB3011" modified="2026-01-28" version="2">MYCLNKAYRIRMFSVQLYGYIIHEFDPWFNYRAAEYMSAHGWSAFFSWFDYMSWYPLGRPVGTTTYPGLQLTAVAIHRALAAAGVPMSLNNVCVLIPAWFGAIATALEALMIYECNGSGITAAIGAFIFMILPAHLMRSMAGEFDNECIAVAAMLLTFYLWVRSLRTRCSWPIGILTGIAYGYMVAAWGGYIFVLNMVAMHAGISSMVDWARNTYNPSLLRAYALFYVVGTAIATRVPPVGMSPFRSLEQLGALVVLLFLCGLQACEVFRARADVEVRSRANFKIRMRAFSVMAGVGALAIAVLAPTGYFGPLTARVRALFMEHTRTGNPLIDSVAEHRKTNPQAYEYFLDFTYSMWMLGTVLQLLGAAVGSRKEARLFMGLYSLATYYFSDRMSRLMVLAGPAAAAIAAGILGIPYEWCWTQLTGWASSNTSARESQSKEDGPCKTKRNQRQTVAAKLDHGARASATAAVKFMETALERVPLVLRAAIAIGIIGATIGTPYVYQFQARCIQSSYSFAVPRIMFHTQLHTGETVIVKDYVEAYEWLRDNTPADARVLSWWDYGYQITGIGNRTSLADGNTWNHEHIATIGKMLMSPVAEAHSLVRHMADYVLIWAGQSGDLMKSPHMARIGNSVYHNICPNDPLCQHFGFYKNDRNRPKPMMRASLLYNLHEAGRSAGVKVDPSLFQEVYSSKYGLVRIFKVMSVSEASKKWVADPANRVCHPPGSWICPGQYPPAKEIQEMLAHRVPFDQMGKKHDDTNKARMARSRTPGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S186</accession>
    <name>A0A088S186_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Abnormal spindle-like microcephaly-associated protein ASH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_020460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009371">
        <property type="protein sequence ID" value="AIN95226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698191.1">
        <property type="nucleotide sequence ID" value="XM_010699889.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22571856"/>
    <dbReference type="KEGG" id="lpan:LPMP_020460"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_020009700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_020460"/>
    <dbReference type="eggNOG" id="ENOG502QU5A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="252265at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39211:SF1">
        <property type="entry name" value="ABNORMAL SPINDLE-LIKE MICROCEPHALY-ASSOCIATED PROTEIN ASH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39211">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1152"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2163"/>
            <end position="2210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3364"/>
            <end position="3387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3498"/>
            <end position="3564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3623"/>
            <end position="3682"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="929"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1152"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2163"/>
            <end position="2186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2195"/>
            <end position="2210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="3364"/>
            <end position="3376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="3502"/>
            <end position="3511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="3540"/>
            <end position="3560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="3640"/>
            <end position="3682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3782" mass="400643" checksum="A45F2467FA903AF7" modified="2014-11-26" version="1">MLDVSCESILFDEVAVNDIPTYRPVQVRNTTESPLLVQFTTTSPVVQFQLRNENYEAIKRTGFADTLSVYNEAFDLVGLISSVELAPFEEKDLIVWFRANTTTFSHLVKGSQPVPYTGSLQLTVVDPALAPPLGNAPSKGGENRVVEQQLAAACIAIPFRANVYISCLELSSTELNITMAPNKTQVADFVVTNTSCQPVYFVIRDQAMPLRGLDVALYESDKFEEPKLGHRLLLDSYSYMTFSLMLRSSMASSTAQQQYHAVFQCDNLRDSRNTAFLYVSVNVVAESQGDLVAFHDTSVNFGDVYRGTKATAIIHIKSLDRVEAVLRLGDVDRRKCEGRVSLMKDDVAVDELAVGSKKGNQLNTVTLMYQPSYDGESNDASKIKFDVELFVVPADRRHSQRVVIRCAAALYTSNIVVSQRCVNFGDCQVGQSKRYTLQIENRSPLPGKIVMQLRSKIIRIEGASIQQKLAGRELKEEFSVAPSASLPITLRITPQRVNAMYRKQLTIINASNPAEDRQVINIEANNMAPLDAKLHDELYSWKCDLGNIDSTDSRRGPSTLWAISGVPLIVPYSVQSKADREVVLNLRSSCSEIEVFYSSDAVVCEQLGKIAAEMRSFCVYGESEDASHLTNDSAGRLFAAREELLRLLNETSHNITNRITLEPSMSLKVYVLIIRTTSPTEPLTKEDGISIAVDGIEAPRFVRLSYRLCGTSFELNGQKTKNFGEVNIGVKKTTKLPIVNRCNSFLYLHLSKSRSVTAEHIRMENSDKRSIFLTIRPYASREIELTLYPGIKGVFQENIRVSNILNIKNTITMTLKATVTKADTFEISPDSWTFEMMVPPSSSVPALMASSPSLWKADEAAAAANARVGAKFTVSNTSNGRRQIVVRLELNSTTAANGVSAANPYLSFAGVKVAVQLDMGLSGAGSVSTRKLEEQIEKLEQKLKIYVRKKKTEKAENAMRKIEAYRLALKGEEVDLAALEAAQSTMQGTTDHELSESEDDGSAAALQAWRSKTQQGDIVQLLRREGVALPSMDIGESVIITLFLGCKRVLDEPIPMTQTQTINMLFYEERDQEANRIIPIDLILISTPGDATGRQLLAAPFVAAAPQTMLASALSASAVVAPSASLSLPSPSHRGSELLQLSTENAAAASASGGALHSGSSLPGSSGTASRAVQSRPLPRIRLITTGSQIGNVGGRFHSTFMGHPLLVLHNCIVNDPTEFSFVVKASAKTTIVVLEPRRCGGSIAAVLDARFKLFPRNGHVRQQEPLRIVVECTARSVGPQKYFIPVKNICNPADVQYLTVEMNPTEEIEMLTTEPKELLFRDVITPCAVSQLEAQLVLIRCRFSFPHALVVRTNRPSQLALFEDASCTVPLLHPIRHIFVKETVRVYVQLRPGARYVDPCARQIRAGVLVEAVAPNPAVSSAAFCVVGKAIVRAMACVGSGLVEVLQGNLDLGCVASTQDFVKTHFTVRNTSHTFSLRVALVPSSPLLEVAEETSAANEIALGPLQEHMVPILVHLPAPGLTREFIDVVNRSSAQEKMRVSLSALRMNDGIVQLDPSINTRLAFPVAAVVRGEQGKQLHLHQPVSYSVKLANYHTHREMVLATTAAVHASCELPLWFHTPDEESKVRAAFEEEQRQALEVTDDAATPTPVADQPPAMYMRGRVELRANHTQTVTWTLTSLPMLTSAEVTAVLQHQMVAITTTLQVCVTYTAHSARAGAAAGGWQGYSSRAAPQGSRYRGPTVGQCVLLVPIMLSLAMSEGRAEPALVNLGLVGKAASMLTSPISVASSVSSTGEEHDAALEQGDDAFAGGREEEMAFAMRQRRRRRSRISKLRRLRDHTFSAYVSKSGLQQPSSHNMVVSFRLMNLSSVMPLPLKVECPPVVRFSQTRLTIPPGESAVVEAALNMKLIATQGTFRYEAFFVNEWNPENDMAVCITGQHYWKVFQVLRADTQEEVHESLTLAPLRVEPSLRGPLAEMKLTFVATEPDVELDLHLQPNPQLDGLLELLLLHYDATSVVRHLNFRTDAVAPLSSGTTSAAGGSAAISVGQGNASPAAAALASHATSGAATPGSGSAIAVMVAGAGAGLGGGSAASGSASTSVGLPGGGMPVSLQSGTTSGVAATAAVIGLSTLGATSATLPADESCGAAATILAGTAGGAPAAVTATSGPAGSSSGSSGVLKAAGSVATKTKPRKMGTSTAPGTAASANSGAVAATTRSQTLRLRCLLRGADLTSLVSLFYGHRKARTAGASAQVTAATAARGTGAGAATTGLTAVAMPAPVDITALEAPGASSSTNTVSWTYDRIAGLERRSASLESNNVWLGTFVMENPFTEAEEVQVYGKLAPFRTFSAPPKVMLRPCRVSVESVPCPGASATAPQAFGSRSTPQVGYVGEISITNEFDVYVAELSVVVLVHEHLAVPLCIDVRGGYRNAVDTTSPGSVAGAAPSVSEVVRENEAATVTDLGAAAILGATPRPGVPVSTSFLAAPSADGAAPVSLPHRIHLGPYETVVVTVVIRPADVRALGLIPMPPTTAASSAPPLSLSLPSLEQFVSVALVDENAPFSYAVGRVSVVTPTSGSEALPSIVLSSVITSDTATAATSVAAASDASTKDEEAEGRRCATLPPIAQRDDSTGQLVTTLATLVDERLSTVLPTPTVLDETPQYVSLSSGKQVSNLVLTSGTSAAASAADAGSSGAEVLPLRGSTSCGSEDTADGPVPLGGILTTLAPSLAAATRQWVLSLRNCDALPGCGGAYLFNFSVPRDDPYEPNILITNHAPDRAVRYTAQVISQSPQVWLLLTSTTGVLEAGETQLLRLQVLSSEVGSFIGYVAITNAYDAREVVYLRLNAEVFVPGTAEGFFDVVAMNSGHRLATTNAGHTVNMGALYGAGTSRALIALEIVNKGSVALEFPVSVVHPMRQELRPIPQRALYSTAAAAASGHRRRDAAAGVLSQRTKLFDGSSTTLLASPPSSRAGLDQQADPTAVGAATDTLAAAQKGAIDGAVLTTAGGAEALLTTQPFVLEKTLPSPHHTRRHYHRRGVRAGSGVAAAPTSTSFSSTVNTSAAPFEGKLIVCQIHGVPTRTGQRYFVVDPRSRMRLAFVLSCNALYDIPEGYGVFGQTDVVFRCKQARDARFSFNVNFEAYRPTFAVAHEYDMDAAERAVASAAAGAALKSEAVGSSATASGPFDGDASSKAAAAPSLASPPPASTATSRWAEVEVSVMNLSRNHAQVFVLYTQSEVLSLSVPGAGPLAHSGCAGSALLPPLPGATAEDDGYSVVAAAGNSGGLAFAPSGVELTVGPQSAGIFAVRLDRLRAEALLKFDKDESMLARPALCEHAFLYNKGNPRERVQLLFRQQALLAHPRRQGRSAAAASSAVAPSPSTLTDAKPVKSDGQHFSERHILGFAQRFSAVMTSLADRVPFLTQPESVVDAVRSHKGVTNSHSIGTSGGGGGSGVVSMIGGEGADSVASVTSAGAAAIRVSAGTAASTVGGVPGSVVSSAFNTAHRSAGRHQRGRRARDSGRVAHRGNTHRSGQRDSFRDDTSDDGTASSSSGTTSTTSTSSNDVDSIDDVASEIAEVAADRMLESMLMEDNFDQPSRDGCNDANDIALGEVIRESSESIVAGCTTGVHSSSDGAPGGLTPYVPLSSSSHPRTRGSAPSTGTVVASCPPSSLPSGTSVAHSNSGGSHLSNEDSHWYDTLITLQDLLVELTWLCDELLFYAILLRNSRHVEASGAFLVSAVAQHPVMVAWRRHRGSSSHARKYGIFGQFLETLDALPRLSSSFSPSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1B3</accession>
    <name>A0A088S1B3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bem46-like serine peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_343890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702811.1">
        <property type="nucleotide sequence ID" value="XM_010704509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1B3"/>
    <dbReference type="GeneID" id="22578894"/>
    <dbReference type="KEGG" id="lpan:LPMP_343890"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340046200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_343890"/>
    <dbReference type="eggNOG" id="KOG4391">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="3">
        <location>
            <begin position="153"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO02011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="394" mass="43086" checksum="2484819AC1FC2EA0" modified="2014-11-26" version="1">MSFGGFLLSAGLYLLLVALFVSLFLHIMSFRYRSQQNRLLYYPQIPPESREVCEDPVALGIPYAERVCVTTSDKVRLWGYMLWPGPSSSVEKGSNCSTPDAIGRTSPNVGTTVGGVRVEVDGAGDLTDSISAGSTLSSSNRNASLSSGMPSFVMLYFHGNAGNVGHRLPLAQAFVAHLKCAVMMVDYRGFGLSDDAEQTQETLELDAQACFDYLWKDPRVPRDRIVVMGTSLGGAVSIHLAAHRHYARRVFAVIVENSFSSIGDMASALSRPILTKLASRCPSLAAGVFDYYVKPLALRISWNSAQKVTKVMVPMLFLSGMCDEIVPPEQMRTLYKAATKCLRDGNGRSLTIPLRRFLEFEEGRHNNLPLMPGYMSAVQEFLTDVRNSGSAAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1J3</accession>
    <name>A0A088S1J3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CYP40</name>
        <name evidence="10" type="ORF">LPMP_344620</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702881.1">
        <property type="nucleotide sequence ID" value="XM_010704579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1J3"/>
    <dbReference type="GeneID" id="22578967"/>
    <dbReference type="KEGG" id="lpan:LPMP_344620"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340054100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_344620"/>
    <dbReference type="eggNOG" id="KOG0546">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="407558at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000029">
        <property type="entry name" value="peptidyl-prolyl cis-trans isomerase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000054">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4 7" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="9">
        <location>
            <begin position="7"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="291"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="324"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIO02081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="354" mass="38481" checksum="26DAE3AC2DA62015" modified="2014-11-26" version="1">MPNAYCYFDITIGGKPQKERVVVELFTDVTPKTCENFRQLCLGNDGKKVEGTEVPMTYHGCTFHRVIPGFMIQGGDFTNHNGTGGVSIYGEKFEDENFTIPCDKSGLLAMANAGANTNGSQFFITTAPATHLTGRHVVFGRVVRGMNTVRAVEQTTTGANDKPVVDCVITGCGALDAVPEVVLAADGDMYPDYPEDVESPMDDAKRIAAAEEIRQIGNSHFTSAAFDFAIDKYSKAVRYLNQVENKDDHPEVDKKLIACYNNSAMCAIKLERWSEARQTASLALSVDAKNAKALFRRGTAALSTGDADSAVEDLTLAHQTEPENAEIAAKLSEAKEKVKMQKAKLAAKLKKMFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1W7</accession>
    <name>A0A088S1W7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_350870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703024.1">
        <property type="nucleotide sequence ID" value="XM_010704722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1W7"/>
    <dbReference type="GeneID" id="22579116"/>
    <dbReference type="KEGG" id="lpan:LPMP_350870"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350014400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_350870"/>
    <dbReference type="eggNOG" id="ENOG502QSA9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272976at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053125">
        <property type="entry name" value="RNA-bd_mRNA_stabilization_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37035:SF7">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37035">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="753"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="756"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO02224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="789" mass="85556" checksum="104F1DB3DC58F853" modified="2014-11-26" version="1">MIYKAYGSPMNSNNAHMYSTYAPPNAYGPGQSASATVYDYASADGHISGIPYGYHTDASLGTTYEYNVGNNMPNGGSVYCGYGSRGNGTNGRDRGGDATGLRHQHGYDQQSTCDYEVHDNQLKAPVVVMPATVVSTLGSARLFSKPPKPIVYGSRCVVRICDAFQEGRCVAGDRCHDIHVRPEYLAEMRMEMSSWLFNRECEFRQAMECDAEKTFSIFVADLKEVVEVPISSLVFTKGLYVDPAMRAKRARGAGSHGHVHAMMQVPTSCGLYSTDPLQCKWERWCNQVHIDHRWMQAKKAEFDQWFIELQSRYFALAPDDIFTVHDPQLKSSIALPKFSIAGFSRGLFQGSMKKLASVCLLFQRGKCTAGSCCNQIHVFPQYLSVAREYAALEQSPDAHCEEKQRLRREMELLRSPLMEQGLQVQGESPAMEAALHPNMVSLANEESHSDAMDLKAATEDDLASSGALFEHVQVDEDVEPASHLVSANTSLTRRLNASVPDINLIGARHMNSDGSYSFNPYGSVTSLPEGSTSYNKFPGTRGSGQLMEGNGAVQYTPGSVQLLSTGTKGMRRLVALVSPELGSSMVEVHRNGDDMGISGNTGDGGFSIGAHEKAAQLVGAHRNNGGYRAIAHPLGDEGGRYDGTAQGEHSCSLHPLDFDASWQFSPPPLLGFDASTTSTHRNGSVRDEDPPMHAHLRLAVSNSSYPYPGSSTTSQQNLLSTPMQRALTSAATAAKVRFATSAASSRAYAHRSATSLPDSYTTNPAMSSSVSSLPATRPSFMGGQTTGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1X8</accession>
    <name>A0A088S1X8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">40S ribosomal protein S10, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_351010</name>
        <name evidence="9" type="ORF">LPMP_351020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703038.1">
        <property type="nucleotide sequence ID" value="XM_010704736.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703039.1">
        <property type="nucleotide sequence ID" value="XM_010704737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1X8"/>
    <dbReference type="GeneID" id="22579130"/>
    <dbReference type="GeneID" id="22579131"/>
    <dbReference type="KEGG" id="lpan:LPMP_351010"/>
    <dbReference type="KEGG" id="lpan:LPMP_351020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350015800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_351010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_351020"/>
    <dbReference type="eggNOG" id="KOG3344">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265263at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000539">
        <property type="entry name" value="40S ribosomal protein S10, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005326">
        <property type="entry name" value="Plectin_eS10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037447">
        <property type="entry name" value="Ribosomal_eS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03501">
        <property type="entry name" value="S10_plectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Plectin/eS10 N-terminal" evidence="7">
        <location>
            <begin position="5"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="97"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="122"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO02238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIO02239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="170" mass="18771" checksum="34A83982379DD9EB" modified="2014-11-26" version="1">MSTYVPKSSRDNVYRFFFTEGVIACKKDRMGTWTGTLGGSTFTVPCIQVMQLMRSLKSRSLIKEQYAWRHYYWTLNDEGIAYMRNYLHLAPSVMPNTQKPSSVNFEKVTEGRGRGRGRGGRGRGEGRGRGRGEGRGRGSRGRGFGGERTNYRAAAAAAMEGEAAPAAAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S200</accession>
    <name>A0A088S200_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TPR-repeat-containing chaperone protein DNAJ, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_350790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703016.1">
        <property type="nucleotide sequence ID" value="XM_010704714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S200"/>
    <dbReference type="GeneID" id="22579108"/>
    <dbReference type="KEGG" id="lpan:LPMP_350790"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350013500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_350790"/>
    <dbReference type="eggNOG" id="KOG0553">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="765884at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052758">
        <property type="entry name" value="SRC_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44200">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44200:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="237"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="779"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="343"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="728"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="345"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="728"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO02216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="855" mass="92518" checksum="AC4283316D7047FE" modified="2014-11-26" version="1">MTQSSTLIRPVLLTKNTSRAYPSAVADVSSGARVATAMKARASPSLYPSLSPDHLYDTKGGSDGEASMSPGTATVQSPYLSRPSPLPPSSQPVGHRRSRRLSLISLNSNSSTSFLHHEQRRSQDERAAGTLRVFNAMPDLSPATKEANGERCCCSADEDLTLGTSGSAPDGVGNIPFTMQVGGAEAAATAVCGARQRGTGVSGAGAHSHDAVNYADPLPSTCAGSDLLHKAGLSGIVVRLKERGNTFLLCEEFELAIATYTEAIRLAPGHEALWGNRACALLLSFRYLPAVADCLYLLHLRPGHTKAYWRAAKAYAATYRLLEAKKFYQLAQQACTRGGVWRGSASISGTAAPSSSMRTSKDDDGTPDTVPTRGAAESTAAEAVGAFCRPGSHFLKAQRDREAMAAEAAALEMVETYWQHLRHERWADALGAMDKVLALPSYTGPTAVSWQALRLEALLHLQPKKALAEAETLYRAYPNSLELYPVLAKAIFYDAHDAAATTRCLSLLDEAAEKRRVQNCLLKAHVSYSVKQLRGGLPADTGKTTALHMETWGKQHCLREDSRTTELRHTIEKFARHRDAGNAAYAVGDWEAAASAYTRCLETDRLNHALLAAVHCNRTAVYMQAGRWQDALSDADAAVSLSPEYATAYARRGRVQLYLLAQEYGGQRATLANRYAAPWVAAMKERLQGYADAAVMDLTRAVELSPTMEHKAQLQQALTQRQAIQALLKSPSETSKASMPSSSAASSEKKRHRGQSAHSSPPPSGARHVESMAIHELVEQLKLLGLSIVAPSAPGEFGRLPEPKVIAKAYRELALRWHPDKWVTATPHEQQRAEQQFKSICVAYQALREHSGALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S224</accession>
    <name>A0A088S224_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Paraflagellar rod protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_050900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="AIN95531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703853.1">
        <property type="nucleotide sequence ID" value="XM_010705551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S224"/>
    <dbReference type="GeneID" id="22572168"/>
    <dbReference type="KEGG" id="lpan:LPMP_050900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_050013900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_050900"/>
    <dbReference type="eggNOG" id="ENOG502RYZ6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265539at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007824">
        <property type="entry name" value="Flagellar_rod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053120">
        <property type="entry name" value="PFR_Component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34732">
        <property type="entry name" value="69 KDA PARAFLAGELLAR ROD PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34732:SF3">
        <property type="entry name" value="ROD PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05149">
        <property type="entry name" value="Flagellar_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="823"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="969" mass="106480" checksum="5B1C6426F9440F56" modified="2014-11-26" version="1">MNMPATLRNATPLGAAPVELGAPTGIMAATQVSSVTATTPPGASERLSALHDNLRRVRHLMQQYEEASQRVIEVHLIPSPEMGEPMFAPVTTPTAHADEDGRVISQQHSSSCTDVASSGDSSAPLCGNGKQGVEQQKASPSLHQHRALASDAVFTRFCGLRVTPAELLLPLQSPANLNIPAAPPALRGIDDHDVDRENWSEDNVESRDAESVKRCGSDNNSRSGQTAGSVNANVKHDSAAGSPRDILSFGMAQQRQRTNVETVLEAYAKLFYNPSPSTPAAGAGAVRELQDTQHQLAAMQRCRLFGHEAQLRAAAANNQGNGNYISTTTSRVETGGVATIGVQVAEIRWQHIPIAVQNMQDSLAALQDRFTRGSHYACCGSQPMALVRQLHTWTQPLLWQLNNLLSNPTLEEVDESTRERLRRMKFDAEEMQQAQAQAIANGDMQRSEELYYEQASLAEAMAGPYDEMEASMLRYRERCVDAPLTGFLEQHDLLTTQLTHMIEENTSKLSEVALDVERVKEKRRTVAQARHRQRNSMSTYHHSWKKAWQTNTDQQMACYRAVAQLEKQLSDLQKAQCFLVDDWISRVAQERQREEDAAAFACFANARSAALAETQRNLQAVVEGVRQYSGAVQFSCHHVEAFVCEVLQGHLSESQLALRKDRLEQFRALYLTLGDLHFKKARNAEEIQKKIEYYTLQQEIAMDALNPKAKEFSQAKQRWEAAKAEALLELGQLDQRIRLQLKGFRPTEQLLRQAGVDFVSPEEDLSRRTQQRSQKLLEYRQLIEEGIGARPTTTASSAASFTPPMLTTLGATAPSAVTGSCARTRSSKGLLGTETTLPPRPWAAGSPHPHPRPPTTAGGLHPSSTIPGALGEKNGCQLPPLRSMSRTYPPLQCRGDDDKPLATSSPHGAKPIFTATAVAAAAATPAFLSSLHSTEERIVQGISKQRLVARLRTGTNRSPLPTSRKANKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S266</accession>
    <name>A0A088S266_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_351640</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703101.1">
        <property type="nucleotide sequence ID" value="XM_010704799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S266"/>
    <dbReference type="GeneID" id="22579193"/>
    <dbReference type="KEGG" id="lpan:LPMP_351640"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350022400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_351640"/>
    <dbReference type="eggNOG" id="KOG0863">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03749">
        <property type="entry name" value="proteasome_alpha_type_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000016">
        <property type="entry name" value="Proteasome subunit alpha type-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035144">
        <property type="entry name" value="Proteasome_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 6 7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="8">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIO02301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="265" mass="29744" checksum="9B2EEDC34EAE8A8B" modified="2014-11-26" version="1">MFKNEYDNDITTWSPTGRLFQIEYANEAVNNGSATVGVKGKDFVVLAALKRSPVAELSSYQEKVFEIDEHVGMSISGLVADGRVLARFLRTECMNYRYMYDNGMPVNQMANMIGEKHQRHIQCSGKRPFGVGLLLAGHDRLGPHLYQTVPSGDVYDYKATAMGVRSQASRTYLEKHFESFLNCTLDELVAHALKALASATSEGVELNVKNTTIAIVGKDTPFTIFEEESARRYLDGFKMRPEDRVVAADYEDEEVLHEQPLDVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2K5</accession>
    <name>A0A088S2K5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_061120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703993.1">
        <property type="nucleotide sequence ID" value="XM_010705691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2K5"/>
    <dbReference type="GeneID" id="22572318"/>
    <dbReference type="KEGG" id="lpan:LPMP_061120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060017600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_061120"/>
    <dbReference type="eggNOG" id="ENOG502S255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="342264at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="528"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="742"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="477"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="769"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="784" mass="84318" checksum="3CCC50AA26B697CF" modified="2014-11-26" version="1">MHTCNSALVLYTSSSLRYCLLRAAGTLALPPLCGAPMSLADMEEADTVEFLSEDSCSTVSALSQDVATTTADTSLPLAANTDEEQLRRHTMHEFAFMPELRPQPSWLEQSGIADDRPFTFVTEMSWDAAHADHLIVAVRWRVTLASSGTAFPTRHATPWVPYAVPLATIITTGTTAMADMVNTVTSTTSSSGDGSGATTQLLGSVQLRLGRSAFLLAAQLSSFGEGAWGSNIARESLANVAASISRAQCTLHLHYAAATTPQAPSLTLTRPVCRSFDIFAISPTTTLLGVALQPHQRYHIKRKRGTGKSAHTVEDQPCNADGVLTLRVGLHCHVDVALDGVPSEPRAVGRTDTCSSTVTNTYNGSHTHTTRSGQTQDGLAVHRTFACQSDVARERPETMMQLRRGWTTSLITGDSTAVLATLSDVSDPVALSGTSDHGNGSPVVPEGQEVAAAPSHAPNTESLGDALRESRKRRRSTTTSGSAAEAVTRRANDAEAVKGEEDDEADAAATPSEIVLFTTGIRLSDAEEKTLKELGSLVNPHLRLARYARVLVAQRPLVRSVKLLTVLPYVHDVVHQSWLDAVLHKRTLDLPVEGYAYKERKIAGSIESENGFDLRKTMGIAPTERQRLFAQQRFWVHKSATPQEPPMNDLKTVLTASGGVVTRRVLDADVLVLPNHKPTLSCWRGIAQQLGGVARALASSTPATLLQCKRAGVLFVVPDDIFKCVLQQRPLSTSTIALPRQFQTEATSPRGSAGAASARRRSSQSKRAPTTQWSSQPSSHKRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S424</accession>
    <name>A0A088S424_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_352130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703150.1">
        <property type="nucleotide sequence ID" value="XM_010704848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S424"/>
    <dbReference type="GeneID" id="22579242"/>
    <dbReference type="KEGG" id="lpan:LPMP_352130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350027400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_352130"/>
    <dbReference type="eggNOG" id="KOG0371">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0374">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="251965at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF514">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="3">
        <location>
            <begin position="461"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="387"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="497"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="590"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="654"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="519"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="626"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="672"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO02350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="884" mass="94878" checksum="8214C71979B27338" modified="2014-11-26" version="1">MPKFSLFGKKEKKTKANEVVRDEGSSVASSTATRADSNNSCKSAKKHRKGITAPHDAASGSTPSGLTASPTGASGPTVEPPQSLSSSSSRKSCSGSATQPLPPPPSTHLTDLCGPRPSVAHLKLQRSRLDDVLISTQRGVDLFPREMSDLTIPQLTEVFQVFQTFLDRCASTVVRQESVLQLHAILPEIAAVDTTMTTESIKAQGFHPTFAIEPMLNHLLEQPAPLRARLCLAIYRFCRELNEELEDDLLSKETGFFGSLQSMNPNLHPTAGSDYGNSEDLCHTSSCSGDFVASQTAKMERCPNIDLPKIYNLLLHKDGYLPSAEELNEIFLRAQELLRAEPNVLMVAMPAVLVGDLHGQIRDLLKNVLALGGPLVSSEALALASPKSSVTKSKTTTSPKSGSGGAAKTFSRAPKSNESHPAQPQNYVFLGDYVDRGPNSLCVIALLFTAKLLSPNTVFMLRGNHECSNTNRLYGFLDECHRLYPIVNNKVTTLRMDATQSPSSGGADGATAHRGGNGSNDPSNTMNVSSSVEPTAAVPNVRAFSAGSSCPDDMGWDMKDHPLWLVANDVLRSLPLCAALCEEVEVDDQAPLPPTTATTESSVKHSIEVDSPENPGTTSSAKELTATKASKSSGSSSANTSFVESFKSKKVEAGKSTAVAGGNARATKDKATNASSESLSSFPKRASTSFTKPKKTRQVVRICAMHGGLSPFIDDSFDGIIAINRFCNIEHGALVDLTWSDPLSSETTRGATTVTFDPNSSQVPLSKFQSTCTFNGTPVGFTGNPRGTGHIFGEDVTINFINTNHLYFIVRAHQCVQEGFQWTHKGRLLTVFSAPNYCGMRNKGAILLLDEKGAPTLKQYECEKIEESPHMTTADAPQPPKLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S4I3</accession>
    <name>A0A088S4I3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alanine aminotransferase</fullName>
            <ecNumber evidence="8">2.6.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ALAT</name>
        <name evidence="8" type="ORF">LPMP_120630</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.2" evidence="8"/>
    <dbReference type="EMBL" id="CP009381">
        <property type="protein sequence ID" value="AIN96391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697044.1">
        <property type="nucleotide sequence ID" value="XM_010698742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S4I3"/>
    <dbReference type="GeneID" id="22573069"/>
    <dbReference type="KEGG" id="lpan:LPMP_120630"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_120010900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_120630"/>
    <dbReference type="eggNOG" id="KOG0258">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="258987at2759"/>
    <dbReference type="UniPathway" id="UPA00528">
        <property type="reaction ID" value="UER00586"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004021">
        <property type="term" value="F:L-alanine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042853">
        <property type="term" value="P:L-alanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000140">
        <property type="entry name" value="alanine aminotransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1970:FF:000001">
        <property type="entry name" value="Alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000104">
        <property type="entry name" value="Alanine aminotransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045088">
        <property type="entry name" value="ALAT1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751">
        <property type="entry name" value="ALANINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751:SF29">
        <property type="entry name" value="ALANINE TRANSAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="98"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN96391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="497" mass="54351" checksum="DB3169B91DE16E1A" modified="2014-11-26" version="1">MLRNVACRLAPKPCHLNPRVIEAEYAVRGLIPSRADEIKADLAAGRGSYSFQSLVYCNIGNPQSLGQMPLTFYRQVMALVDAPFLLEDPEIVARLPVDAVARAREFLAEIGTGTGAYTESFGYRFARAAVAAHINQHSHHVGPAATVDDVCLTDGASTGVKVFLQVLIGGSSDAVMVPIPQYPLYSAQITLLGGVKVPYYLREAEGWGVQASDLAAAYDQCVAESDATPRIFVCINPGNPTGNVLERCVMEDVVRFCHERGMLLLADEVYQENVYDPRRQFVSFREVVLGMPEPYCVETMLVSLHSTSKGVIGECGRRGGYFCMTNLPGELRAQVTKLCSINLCANVNGQVMTALMCSPPREGDASYALYRREYDGIFTSLKERAALLARELATVRGLSCQPVEGAMYAFSTITLPARYGARNEELNAKEGRQLALDARWALELLESSGVVVVPGSGFGQAAGTLHFRTTILPPLAQMERMVHAIREFQELLYKQYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S4Z6</accession>
    <name>A0A088S4Z6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Squalene monooxygenase</fullName>
            <ecNumber evidence="4 9">1.14.14.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_131490</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>squalene + reduced [NADPH--hemoprotein reductase] + O2 = (S)-2,3-epoxysqualene + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25282"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:15441"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the squalene monooxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.17" evidence="4 9"/>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697229.1">
        <property type="nucleotide sequence ID" value="XM_010698927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S4Z6"/>
    <dbReference type="GeneID" id="22573259"/>
    <dbReference type="KEGG" id="lpan:LPMP_131490"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130019600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_131490"/>
    <dbReference type="eggNOG" id="KOG1298">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1678617at2759"/>
    <dbReference type="UniPathway" id="UPA00767">
        <property type="reaction ID" value="UER00752"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004506">
        <property type="term" value="F:squalene monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013698">
        <property type="entry name" value="Squalene_epoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040125">
        <property type="entry name" value="Squalene_monox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835:SF0">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08491">
        <property type="entry name" value="SE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0274">FAD</keyword>
    <keyword evidence="5 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Squalene epoxidase" evidence="10">
        <location>
            <begin position="210"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN96576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="569" mass="63382" checksum="9304780D96E7C704" modified="2014-11-26" version="1">MLYFFATVLCAFGTLLLLNRTLSRLRVSPARTSYDYDVIIVGGSIAGPVMAKVLSDQGRKVLMVERTLFTKPDRIVGELLQPGGLNALKEVGMKECAESIGMPCHGYLVVDLKGDQVDLPYRKGASGVSFHFGDFVQGLRSYVFHNCKKNVTMIEGTVNAILTEGFSFSERAYGVEYTVAEKYEVPANPFREDPPKADPMVRTVRRVATAPLVVMCDGGMSKWKSRYQHYTPASANHSNFVGLVLKRVRLPKEQRGTVFFGKTGPILSYRLDDSELRILVDYNKPMLPSLEKQSEWLIQDVAPRLPEHMREEFIRVSKDTKSLRSMPVALYPPAFPCIKGYVGIGDHANQRHPLTGGGMTCCFRDAIRLANSLKGIPSLRSANQDEMAAIEDTVQSAILNYVRFRYTHSCCINLLSWALYSVFSTPALRDACFDYFVCGGECVSGPMDLLAGLDPSLGALIFHYYGVVLYSVANVIMGVGVHNGSGKQLSDLEKLMNVASFFVDWGRMKHAAYLLGKSTKIALPLVKNEFFSMWRFVDPTSPLANISKRIKMMIYARQFNGKQRKPVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S656</accession>
    <name>A0A088S656_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_170030</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697694.1">
        <property type="nucleotide sequence ID" value="XM_010699392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S656"/>
    <dbReference type="GeneID" id="22573746"/>
    <dbReference type="KEGG" id="lpan:LPMP_170030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170005600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_170030"/>
    <dbReference type="eggNOG" id="KOG0800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:001080">
        <property type="entry name" value="Anaphase-promoting_complex_subunit_11_RING-H2_finger/Zinc_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46463:SF74">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46463">
        <property type="entry name" value="ZINC FINGER, RING/FYVE/PHD-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="62"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN97041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="193" mass="21812" checksum="80E2F7B34759243D" modified="2014-11-26" version="1">MQENLHTKAAVAVRIPAVASVSSAPVESQNASCSNLSDYINEDSVAGDLETYDVGEYHLTTCPICLEHFTLDNPAILLKCEHGFHLQCLESWRQRSTMCPMCFAPVIGDEGRLMSSSDVRRRRCMRLRPPPVTHHALERSSLIIPTGAQRLPQPNCDIEHASEQDEEIETIEVRAHNNGLYWVWSWFRQCCAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S6W4</accession>
    <name>A0A088S6W4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mitochondrial carrier protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_181000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697934.1">
        <property type="nucleotide sequence ID" value="XM_010699632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S6W4"/>
    <dbReference type="GeneID" id="22573990"/>
    <dbReference type="KEGG" id="lpan:LPMP_181000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180012900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_181000"/>
    <dbReference type="eggNOG" id="KOG0765">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="250329at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46080">
        <property type="entry name" value="MITOCHONDRIAL SUBSTRATE CARRIER FAMILY PROTEIN J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46080:SF18">
        <property type="entry name" value="MITOCHONDRIAL SUBSTRATE CARRIER FAMILY PROTEIN J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="4">
        <location>
            <begin position="328"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN97281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="457" mass="48771" checksum="47B0431DC688B3B5" modified="2014-11-26" version="1">MTTIESSSPRYTDSVPAAEVSGALSSIAATAALPASGGLSTNAVTRNFSDLHAPTWIALLSANIGARTLLFHPIQLAISRKRVTRESTPPTVIGLMKASYRGGRTSAYDAASTKGQYDFGKGGIRGCYRGVGAALLCNLLGETSYLFTLEAMKEYVEAPSSKSAGDNIFAASGYSAAVGAMCGDLVALLLVSPLVIVCNRQMTAGYSMASTNSYMNVPQTFRTVWGLHQKKAVATGRVWPGERVRCGLCGVYQGLSAGLLRIPSSGCWWGLYTKSKETLYIASAPTLSVWEQEYRYTAAARDPSTAAAPSATKSTLLWQQNWLLSPTDNPLLNAVASVIASVFTTLLFNPIAVVQTRQQALPPGLWEERMAAAARGGSAASSPSPAVHKQTWKSLLPFRRVYHVANDLARKEGVRGFFKGAPANMSVAVLDGIIFTLLFEFTKLGSDIQLLEKHHTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S6Y4</accession>
    <name>A0A088S6Y4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ttaggg binding factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_181250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697959.1">
        <property type="nucleotide sequence ID" value="XM_010699657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S6Y4"/>
    <dbReference type="GeneID" id="22574015"/>
    <dbReference type="KEGG" id="lpan:LPMP_181250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180015800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_181250"/>
    <dbReference type="eggNOG" id="ENOG502SAEM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="608866at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="670"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="777"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="575"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="679"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="801"/>
            <end position="810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="810" mass="85200" checksum="5F838340ED270A37" modified="2014-11-26" version="1">MPLAGPSSIAATLASGNRASAAVQLQRETRHSVGADSATMAKCDDSRGSDGLLTNAKHDVHYFDVLHPILLSHVRRANSDGVLALLSLPSIAESDVFWRTCTYREGLVAAVLIYVMEHTGQLTVPAHLLTLSTPTATAASPPGVLVTSNGPADNSPVCSPESTSQTRRQPSLPSPWPRYSPALVVPSDPVTATDDGLSPTSHSFPITSLAVDDLHTLLHLCSREGAEAPALDEGHQSVPSPQEHMYEGSAERPFILDRRHPPALATLLRVGKELRQQRRGSTASRRDAGAFSLPRRPTGALRQEAVDMDLELYIQSVMRRLEAMRGVPKQAEEHNLDGPGVITRKRPRWSDAPAAASVGTSSEGKGSGILTSSDPDPLRDPCGEDIVAVPTNAVDLAALAAVLQEHCHSMVYVNPFNDHPAASAAVVESTDSTAPTATTAIGISSSTSNGSRTNPVHATDITTTGHTTAEAAAAKTSIADLVDAAPEPVSEGAERANKVVIQDSDAQDVPGGLDAVALLRRIPAISATRWVLPSDERNTSGTGETGSGARDPLLAPSATATGRRVGAGQRHPTGAAAPASADSLPLLKPLPSSPTHTAAVERQTNATEEQARVSAAIRAFDVFTAALEQSAGPTAGTSAGSLQSTCAPTAPLSSLSTGNLSSRRTAARLVTPGAIHSRPPGPRLPPPPRSSSTSEVRRRYKFSPQEDAAILHGVARYGQMSGSFQYILHAYRSVWRAGRTALHLYDHWRGALRRRAVAAASEEVPSHTDTNALNEALHDEDEAMSMSPIHPATPDKQDLSSDIEDFSDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S6Z4</accession>
    <name>A0A088S6Z4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_181400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the recoverin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697974.1">
        <property type="nucleotide sequence ID" value="XM_010699672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S6Z4"/>
    <dbReference type="GeneID" id="22574030"/>
    <dbReference type="KEGG" id="lpan:LPMP_181400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180017200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_181400"/>
    <dbReference type="eggNOG" id="ENOG502RXGZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF178">
        <property type="entry name" value="NEUROCALCIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="143"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN97321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="235" mass="27102" checksum="07867D0B08FF259F" modified="2014-11-26" version="1">MGGRISREQMNDYREVVKDRLSEEAIGFLHTRFMKAAPSGVMTPLLFKHYIESVGVFKSRKIREEQRRRQQGSIFDKLGSGRYTHKGEKLGAAAGGNQGGGKDAAQEDGIDYYQHLFRGYDLNNEGVITFKKFLIYHVAIVYSTEDLFYVVFNTYDEDGDGFLSLKDIKAVITAATRYVGDYDVNDREVCRVIDEESRRLMGFLDIRKQGYIQMEDMRLITQKYPHVLEKMKCLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S7A4</accession>
    <name>A0A088S7A4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Band 7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_191140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698109.1">
        <property type="nucleotide sequence ID" value="XM_010699807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S7A4"/>
    <dbReference type="GeneID" id="22574168"/>
    <dbReference type="KEGG" id="lpan:LPMP_191140"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190018700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_191140"/>
    <dbReference type="eggNOG" id="KOG2620">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="434619at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="CDD" id="cd03407">
        <property type="entry name" value="SPFH_like_u4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050710">
        <property type="entry name" value="Band7/mec-2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327:SF10">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="1">
        <location>
            <begin position="6"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="277" mass="30758" checksum="356584E8B8036CF7" modified="2014-11-26" version="1">MGTCPSISQSEVGIVETCGRFSHIADPGIHCLWCGSTLVRRITLRLQEYELKVESKTKDNVFVTLSLVIQYQVASNKFAEVYYACDSSLECMRDYVLNSIRAKIPLYKLEALYVERGTISQQLKDEVDAIINTYGIEIVSALISDIDPGAEITKAMNEVQRFQRLRVASVDAAETEKLKRVRAAEARCEARRLSGEGLAEQRKAIVAGLMQSIGDVQSEVRDLTSDDATNMLLMNQYYDTLQAIAANSSSSVIMLESNGGLEKVATQLRQGVTHMMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S881</accession>
    <name>A0A088S881_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amastin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_203001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698503.1">
        <property type="nucleotide sequence ID" value="XM_010700201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S881"/>
    <dbReference type="GeneID" id="22574511"/>
    <dbReference type="KEGG" id="lpan:LPMP_203001"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200035900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_203001"/>
    <dbReference type="eggNOG" id="ENOG502SIEJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264260at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009944">
        <property type="entry name" value="Amastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297:SF4">
        <property type="entry name" value="AMASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297">
        <property type="entry name" value="AMASTIN-LIKE SURFACE PROTEIN-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07344">
        <property type="entry name" value="Amastin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="203" mass="21906" checksum="9648C3E3D02AD108" modified="2014-11-26" version="1">MCNIPCRAGIVMYCVLQLIAFLFLLVGTPTGQFRVPNKVAFSGGSCLTVWGLKNKCTSTKWDVRTSNLWAGCPERLKRFHAAEALSVASVVVSALAFLFGVVMLCCCRCLRGLCLVLNILATGCGCAVTALMVDAFYNNHENGPAQYNTSCYALRKNGSVTQPQAIADGDPVVTNYAYGAGFAVYIVGWSLCFINILFLMLPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S8I0</accession>
    <name>A0A088S8I0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="9">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LPMP_204220</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="9"/>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698623.1">
        <property type="nucleotide sequence ID" value="XM_010700321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S8I0"/>
    <dbReference type="GeneID" id="22574633"/>
    <dbReference type="KEGG" id="lpan:LPMP_204220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200048300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_204220"/>
    <dbReference type="eggNOG" id="KOG0215">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 18" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 18" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 9 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="14">
        <location>
            <begin position="25"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="13">
        <location>
            <begin position="178"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="15">
        <location>
            <begin position="443"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="16">
        <location>
            <begin position="542"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="625"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="11">
        <location>
            <begin position="671"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="12">
        <location>
            <begin position="1036"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1016"/>
            <end position="1037"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AIN97916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1125" mass="126273" checksum="4C63A04AE9D28B4D" modified="2014-11-26" version="1">MAGFGEEYQRKKLEMLPALMAMRGILNHHIASFDHLIEVELQRILLNESNVEIKSVVDPDFLIRYQNIRVCRPQEIVGKGHIPKFVTPQECRIRDMTYRGDMIVDVQYTSRDRSRAMLVEKDVKIGTIPIMLKSKCCNLYRKTREELVSMRECPLDPGGYFIIKGVEKVCLVQEQQSKNRVIIEADEHGNISAHVQSKTHYSISKCAVTFKKGSIVLTHRSFTEDIPIIVVLKALGLENDQHITQCIGTSPAFQKILFPCFEEARGLDIFTQNDALQYIGEKRKETVWEVEETQQRQVNRSKADKAAEFLANVLLCHIREAQMQKDWNFRHKAFYVCFMVRGMIEASFDASLLDERDFYGNKRFETTGTLMALLFEDLLKQFNRVVKTAMDQQLSKRDSTRPFNVKQLMESKMEVIQNGMRMAISSGRWDLKRFNMNRQGITQVLSRLSYIACLGMMTRLASSFEKTRKVSGPRSLQPSQWGMVCPCDTPEGESCGLVKNFATLSQVTLDMSDHYVRASAHSLGVEEIDTVTPTDFLQYYSVFLNGTLIGIHRYPNRLCAGIRALRRSGRLHPHVSISMQPRQRTVQIGSDGGRIVRLLIIVRGGKPAVTSAHLDRLRDRLCTHNDFLAEGLIEYVDVNESNDCLIAVYPADIGPYTTHLEVEPLSLLGVVAGIIPYPHHNQSARNTFQSAMGKQALGTVALNQYIRADTVLLLGAYPQRPLCRTRAMSLTHYEKLGAGINAMVCVMSYSGYDIEDAQVYNKSSLDRGYGRCVVLRKHEVDLEKYAGGEFDVILPPEKNSGSGKFKALNPDGVASKGAFVQQYDVLVNKFTPVAGGDPRPAPLVYKYPQLAVVDHVIISPPGDYDRSLDVDQKIKVITREVRPPEPGDKFSSRHGQKGVVGLIVNGVDMPFNERGMCPDMIMNPHGFPSRMTVGKLLELVCSKAAALRGSMGDGTAFGGDSADSISRQLLSFGYNYHGKDVFYSGITGELMQGYVFFGPIYYQRLKHMVTDKMHARSTGPRSMLTRQPTEGRSRSGGLRVGEMERDCMVGYGASSLLNERLLISSDLFTADICHVCGNLGYNNRCTYCKTKGTTSKVNMPYAFKLLIQELQGMGVSLRLTMDSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S8S5</accession>
    <name>A0A088S8S5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Calpain-like cysteine peptidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_205400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN98031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698738.1">
        <property type="nucleotide sequence ID" value="XM_010700436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S8S5"/>
    <dbReference type="GeneID" id="22574752"/>
    <dbReference type="KEGG" id="lpan:LPMP_205400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200060900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_205400"/>
    <dbReference type="eggNOG" id="KOG0045">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="167576at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF423">
        <property type="entry name" value="LEUCINE-RICH REPEAT PROTEIN (LRRP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="3">
        <location>
            <begin position="1"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN98031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="544" mass="59914" checksum="AF5F287126E77024" modified="2014-11-26" version="1">MAAVAEHTHLLLRMFRHPFSQQRGAAEQCLGAYRVTLNVRGWWHSVVVDDYFPITEGGCYIKYAHSRRDVRELWVSLLEKAYAKVRGGYSNIVTGDPLMALRDFTGWPCARYDIAHFNNIALASSSFASRLLRYDQHGFQVILHTAPRFDSAGPMLQTDIGISPAEAALPSIVEASGGGACAGASAARGLIAGMVYPVMRILRLSIDTLRAELTLFQVRNPWRDVAAWKGRWRCGSRLWKQWPHVAAACHMQECSHLDVNGDVTLSTDNLRDKSVAPPAPQAATTNACACRRNQYIWVEWSEVYRYFSGCGVVFRLPLHHEYRVKGVFEATCPSVCVRVSVVARTFIGAMLSIGDTVGARSLATNTGDTSPYPPIMLTLAREQDGVLHLVCNSQLDPDNPSARFTFMQTHDASLFYPLTPENSPYWLIPRVLAPQVPNAAAATDGGASAPAPDPPRLPYVLGLFQEEQAGENGWRAEFYHLPPTSAAFRNSTSFSLGSNVRAVVAMFQAKAPHAAFPKTYVNTEVSEREATPVDEFVGAAQTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S9M2</accession>
    <name>A0A088S9M2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_220420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699043.1">
        <property type="nucleotide sequence ID" value="XM_010700741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S9M2"/>
    <dbReference type="GeneID" id="22575088"/>
    <dbReference type="KEGG" id="lpan:LPMP_220420"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220009200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_220420"/>
    <dbReference type="eggNOG" id="ENOG502RQW4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272790at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1001"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1095"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1003"/>
            <end position="1017"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1127" mass="125035" checksum="D0F1FFA0793D2956" modified="2014-11-26" version="1">MRAERLRELEDFLQQRGGQRTSIEDRHKVIQKALSLLPVVYPLLTKVVAWMRRYSEDVVATLRRAAEDKAEALKQQQKELYEQFETFFEGKIRELMRVRKQATAEAEAEHAAAFALRQERDVELLAIKEQLVERMNSCEKTEDQFRDFRHLIASVFQANQQLGLRIEQLVDTLADHNIPIPPASSEVMALQTSSDGQQSFRPRASNADGDDASRGDSECSGGRRRDGDAKFHNVPVEFMAAAKHELVKSRLTLQEELLHSAFDDRCAYRMRIAGLTQQNLDLKFNVSELEEKVRDLYTYVHEKRFVRQVDEQGDEAALTPRPREVPLALQTELGIELRHSTANILSELSTLAINMKHQLNAALLRARQLHTLSTWLDEGNEAAFSEGAVGGMLQRVSEATVIPVFSVSAWQSIPHFLRTTITPDVPNYYWTEAQAACILHNFFKAYRAIRRRARFVRDSKMLAPRTCQLFEHREVLLTRLDASKEDVAATEENVPFGYVVTQFARDVLSNLSPQNVQAELPLVLPGTVALRLPTATITSSPFNVLPGGNGSGDTKHSPGLQQTPTANERLTVEDCPWKVAVPIVELELTRFTYNMWYAAVRYQPSQPLCDLFLKLVDGQMPIETFDLMEAVLSRLRRRIECLDGAGTRRFAYSRLVKGIVRSVTDMDAKAVLRAVQAVAQAFEANHMPLYGGALDSVALFADETYCKREAFATSFEEEVALCAGSPMPDSATAEAAAKKMERTPLPSSLITREVPLPTSFTASSPPSMLPPVGATCIVRFCRHLVHDTVEGLYTRIEAVLCPLVEESEVVLGLYLLPLPRAKAALAALDDMTRQEAIHAALVGSPEAVAGSSLARVTIGRISAAAYTGMQLTAEAANLLGVRGLTHDYMNLLESRRNVVEEKRTEERHITAHMVDKAVQGLPRFKTSTHFPFHSQHVAWIGTVGELTDSNVLPKADSLLENDATLNKAAAAAGSESNISVKITQKGRKQKLTQAVVGTHRSGHVAEQHGSEKADIKARSSTHATRRRNKRIKQANLASLKGERPDSAEYSDAVRSRTAKALLAASEEGDLVEWYSLRHALRCTLPSLPWQIFQPDEPESEQEKATIAGASGPGTLPVLTASEVKAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SB84</accession>
    <name>A0A088SB84_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_250560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699628.1">
        <property type="nucleotide sequence ID" value="XM_010701326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SB84"/>
    <dbReference type="GeneID" id="22575704"/>
    <dbReference type="KEGG" id="lpan:LPMP_250560"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250010400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_250560"/>
    <dbReference type="eggNOG" id="ENOG502QQAX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="278163at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041090">
        <property type="entry name" value="DUF5578"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34258">
        <property type="entry name" value="ARMADILLO-LIKE HELICAL DOMAIN CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34258:SF1">
        <property type="entry name" value="ARMADILLO-LIKE HELICAL DOMAIN CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17741">
        <property type="entry name" value="DUF5578"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="677" mass="71376" checksum="54EC764BCD54E1E4" modified="2014-11-26" version="1">MTGARTAHAGGAANSRRGVSQPTATAVTLLSSSTVRLAIAQPSAASAAAKQRPQQRLRANWSASAVAPQLRGHRATAWLSVWDSACAARRVCMLESLTVLHHASNSNALEEDLGGAAPLLLTRITSWWKLRYGAWVTDCVSSMSSASTKAAAAAAAAAVDAAQKTSARSGAASAIPPSATVSGSNANVAPDGPSLPRASCLSGSTAPSSELLAQIEAITLFLRGSRFLLQFVEGGGVATLTHCLETTAHASLPSSTSLPASAAAATSSTPALFVLERRAITLLLLHVVNAGRVYREMVGDKEGLLHVLRALQLETDALVAAPLTELLAVLGQGHPRMANIVQTGLLRVLADAVQSPEDLTTPGAKSLAGPWRVSEVVVLHTARALRALQLQREQHHYAQFYLGGCTDAALGAGADYVPIVGMDCASNAYSTAETAAGPPSGSSYACDALLRPLSRGKYLDTLFQLALDDQHKALQVEGNELLCLAAKSLHFTQDILTRCLDVVDSDEYVIRGDDADANAQQERLQRQRRQLSCGRTAVLLLISRPMTSQRRQLMLSLVLQRSGYLTFLKHLRLTKHGDTATVVDCCHALQFIVRAAAEMQRQDMDRCGVSKLKAVSGADSDSTSGAMWLRVTEGVQAALGESVFQLLLFQKLSESDCMGVLRAARAAVVPVGGAEAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SBR1</accession>
    <name>A0A088SBR1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_252480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699818.1">
        <property type="nucleotide sequence ID" value="XM_010701516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SBR1"/>
    <dbReference type="GeneID" id="22575896"/>
    <dbReference type="KEGG" id="lpan:LPMP_252480"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250027000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_252480"/>
    <dbReference type="eggNOG" id="ENOG502SZJA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="262608at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="68" mass="7766" checksum="51F8DE11C859C9B9" modified="2014-11-26" version="1">MNAEQTKMAKKPKDGSWRNKFVEDAAVIYSKDTTNRLTDFAGAFLILCISVYFTTSGYLFYRELALSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SD23</accession>
    <name>A0A088SD23_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_272420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700328.1">
        <property type="nucleotide sequence ID" value="XM_010702026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SD23"/>
    <dbReference type="GeneID" id="22576420"/>
    <dbReference type="KEGG" id="lpan:LPMP_272420"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270032100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_272420"/>
    <dbReference type="eggNOG" id="ENOG502S0CJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="256304at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="153" mass="17906" checksum="B6AE83BFEEC5A5EC" modified="2014-11-26" version="1">MKRLQLVCPAAMVPGCGAAMQCSRRWNLLEHRTKGSPYMKHLDLYARRDPQLAPYLLREVDIEYKRKCRKVSFLVWVAVFTVAVAWQTRMQGEALHYMRLYASYVRAEQDAKDEDNIKRRKAFVGVINVVKNAFDRDQRWTAADEAKALKELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SF83</accession>
    <name>A0A088SF83_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ADF-H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_302490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701272.1">
        <property type="nucleotide sequence ID" value="XM_010702970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SF83"/>
    <dbReference type="GeneID" id="22577302"/>
    <dbReference type="KEGG" id="lpan:LPMP_302490"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300029600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_302490"/>
    <dbReference type="eggNOG" id="ENOG502QW1K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20822at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11282">
        <property type="entry name" value="ADF_coactosin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829">
        <property type="entry name" value="CORTACTIN AND DREBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829:SF25">
        <property type="entry name" value="DREBRIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="2">
        <location>
            <begin position="174"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="411" mass="46505" checksum="53CA0DAB5435565A" modified="2014-11-26" version="1">MPKVVCVRRGSDEIDNAIERLDEAKVQLLYSKFPVGSGTFKRNKFIYVQYIGPKCGIVKRGQGINEIANFTTNNIRGVPGFSTTEKTSLSFEFLVRQMRDTFVTDNGNFSMEQIREEYRERLAAEQKMMHREREQAAVVAATARRARRNSAPSVRLAPNPVPPSLKEEEEQRPHSPVELSEKTNRIMASLRQDNGSINWAVFESNLETLTVRAYGRQGIFEMVKNLPDEAWLFGLFRIAFSDGKVRQRRIIFFQWIGSNLKALGRASHTGVYPAMAKALSPFNYEIYLVGRQDLNPQAIIAKSKSAFRTPADRRVGVAQDFLMDSTVFTEENYRQSLVDELAHAEAFEERPKRSHRQTMPIVPDGMEQSLASLAESMTADSPAAHSFSIQETIDLVQANEGGLVWAIFEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SIZ8</accession>
    <name>A0A088SIZ8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ER--golgi transport protein gp25L, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_341700</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702597.1">
        <property type="nucleotide sequence ID" value="XM_010704295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SIZ8"/>
    <dbReference type="GeneID" id="22578675"/>
    <dbReference type="KEGG" id="lpan:LPMP_341700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340022900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_341700"/>
    <dbReference type="eggNOG" id="KOG1690">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="759142at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="9">
        <location>
            <begin position="40"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIO01797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="216" mass="24998" checksum="8D5425808199520F" modified="2014-11-26" version="1">MGLRVFTSLVAASAAKLLVLVVLLSCTVTGFVFQLKSGESRCFFQEVPSDTDLRMVYKSDDTYGDFLDVVLTNAESRTLYMEYSRSNGAFVGRVTNGGEHMLCFSSRQGMQSAKSTRNILLVMQLGADAKDYDTMATKEKMRPMEVQMRMMEDTVQEVHNEFIYFRAREAEMRNTNEHMTAKVMWMSIGLIILFGIFWYLQMRHLKRYFKKKRMID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SJ07</accession>
    <name>A0A088SJ07_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_341810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702607.1">
        <property type="nucleotide sequence ID" value="XM_010704305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SJ07"/>
    <dbReference type="GeneID" id="22578686"/>
    <dbReference type="KEGG" id="lpan:LPMP_341810"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340024000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_341810"/>
    <dbReference type="eggNOG" id="KOG1363">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1026733at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049483">
        <property type="entry name" value="FAF1_2-like_UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF1">
        <property type="entry name" value="FAS-ASSOCIATED FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21021">
        <property type="entry name" value="FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="3">
        <location>
            <begin position="246"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="177"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="177"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO01807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="332" mass="37608" checksum="F5AC7555B8D8B6C3" modified="2014-11-26" version="1">MLVHEVEKRYKLKVPFFQGTLEEAKRHAQHDSRYLVLYLHSPQHENTEAYLREVLATDEIIALLHESSVLFGASVADAEGTLLAEELGAHAFPFVAALVGNTVVLRLQGYHSRETFCREWRLCTDDWDGHLAEGVVLAAEREAREQARIAEAEAASAMEAADRAMLEKLLRKEEEERRAAAEREAAAQRAAEERVTAERLEAEDRARQAAEEARQRALEEERQRQRESAKQAAKSQLHDEPSTDLATHETVQISVRCPSGKHYDRRFLRSDLVDQLTFFVMTLDELADATDASTVRFVTGFPPAPLEWREGETCFGDMKSLCPRAVVLLRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SJP9</accession>
    <name>A0A088SJP9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_344150</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702837.1">
        <property type="nucleotide sequence ID" value="XM_010704535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SJP9"/>
    <dbReference type="GeneID" id="22578920"/>
    <dbReference type="KEGG" id="lpan:LPMP_344150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340048900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_344150"/>
    <dbReference type="eggNOG" id="ENOG502QYKI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="49058at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd10142">
        <property type="entry name" value="HD_SAS6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.210.20:FF:000002">
        <property type="entry name" value="Hypothetical_protein_-_conserved"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.210.20">
        <property type="entry name" value="Spindle assembly abnormal protein 6, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053997">
        <property type="entry name" value="SAS-6_C_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032396">
        <property type="entry name" value="SAS-6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038558">
        <property type="entry name" value="SAS-6_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44281">
        <property type="entry name" value="SPINDLE ASSEMBLY ABNORMAL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44281:SF2">
        <property type="entry name" value="SPINDLE ASSEMBLY ABNORMAL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22218">
        <property type="entry name" value="SAS-6_C_CC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16531">
        <property type="entry name" value="SAS-6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spindle assembly abnormal protein 6 N-terminal" evidence="8">
        <location>
            <begin position="144"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="SAS-6 C-terminal coiled coil" evidence="9">
        <location>
            <begin position="268"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="56"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="710"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="297"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="355"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="485"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="741"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIO02037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="812" mass="89714" checksum="960ACB4D7CC65117" modified="2014-11-26" version="1">MIHSYHQSSSVMSTEDGSSSTVFGNPRIEQRRRHVQQQHLPRLPCSCEPFSETLQSSFKARQDPIAEYEPRRNGEDSNPMLLRNEGGRSNMPHVEGMEGGAISPPSMRTARTDLPALASPKPSAEESRALLETVVAVSTKMPPHEPQVRPLGVYVRTSRGGPNGVTRVVLVRLTDPSDPFFLFELELLEDDYSAFKQRLELLVDFHGFPRYLVGMLRDIADGASAYELSFVLNNAAVGDSNRGTLRVLETTDFKTVEHISLVLLRQGDAGLKRYLAERFQHYEQSFRASEASRIAITAELKERIDDLQVANDALRARLRKTEEEMRFMTTDAEKEQLVALNRLRDHHTKEMNGTRESFDKKIEQLSHALEEKTRQLRDTTNEKEAAMAEARARTSDLEATVTSLQSHLRSAQDTVGVQTKELVALREINDELANFKAEATKAMSENELNYVTLAERLRGTSTALQSREEKLAALQAHYEKQDEYIRILAEQNKQQADHVREAEKNLDKAHHIIANQLQAIKNAKDRYHIAMDQLRSQETLLQEREGAARRQQEELLAATERVQELLRKNSDLREQLESINNAREQLVQEVKLSQQALLRLQQTTSINGRHWGVLSSAYQSREGATTGVSTLDATAGAGSTDFMREFGANAHVLNLPGYRSLNLPFRSSVYRSTNLGKTGLVAASGALSPSSTGAVADGVTVTERPSLFATKAASPSPVHSSQERAGSAETAGLTEPHGRGSMSSLSKTERTSGTAAASASQLPVKSASLNKQSSHMGRSSFNGLAVKSFLGGEDASQRAAVTAGPALESAYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SJW1</accession>
    <name>A0A088SJW1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_344780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702897.1">
        <property type="nucleotide sequence ID" value="XM_010704595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SJW1"/>
    <dbReference type="GeneID" id="22578983"/>
    <dbReference type="KEGG" id="lpan:LPMP_344780"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340055600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_344780"/>
    <dbReference type="eggNOG" id="ENOG502S8HS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272891at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO02097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="204" mass="22888" checksum="EB7D2D21EB922688" modified="2014-11-26" version="1">MLDYLIPIGMALAGVFIMMFIFQNISTSEIGSDSIVPARKPRSKRSQRPSQKYTDDVLDLATEQLIACEVARNPSGMITDSKTVTPQTLDSIRGRRQAKEEGQRTQTHAKVSERQKQSAKDQGFKVVENLKGLPKQQHQQEKPQFESESATSIEDLDRKLSLFFKTNGSRKVKEVNLKEEVPAESGLNRGHVVLKGDLSKAKCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SKF9</accession>
    <name>A0A088SKF9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_351700</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the proteasome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703107.1">
        <property type="nucleotide sequence ID" value="XM_010704805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SKF9"/>
    <dbReference type="GeneID" id="22579199"/>
    <dbReference type="KEGG" id="lpan:LPMP_351700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350023000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_351700"/>
    <dbReference type="eggNOG" id="KOG0175">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="37597at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03761">
        <property type="entry name" value="proteasome_beta_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000034">
        <property type="entry name" value="Proteasome subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF3">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6 10 11" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIO02307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="302" mass="33439" checksum="64836E87277BFC6A" modified="2014-11-26" version="1">MFTDFESIMTSNFTLEDCPHIGPFTYHNINEDTLDEPLSLCSYRRAPQQTTKGSPASCDAVTADPLDSSRHLHGENRCWTLTASCPVPRAIPKIDMKKGTTTLAFRFDGGIIVAVDSRASTGQYIASQTVLKVLEINDYLLGTLAGGAADCQYWERVLGMECRLWELRNGSRISVAAASKILANITYAYRNHGLSMGTMVAGWDQFGPSLYYVDDKGSRVKQDLFSVGSGSIYAYGVLDTGYRKDLSVEDACDLARRSIFHATYRDGASGGIVTVYHIHANGWTKISRDDQTKLYDRYFPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SKN2</accession>
    <name>A0A088SKN2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LMSMT</name>
        <name evidence="8" type="ORF">LPMP_352450</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4 5 6">Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703182.1">
        <property type="nucleotide sequence ID" value="XM_010704880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SKN2"/>
    <dbReference type="SMR" id="A0A088SKN2"/>
    <dbReference type="GeneID" id="22579274"/>
    <dbReference type="KEGG" id="lpan:LPMP_352450"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350031100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_352450"/>
    <dbReference type="eggNOG" id="KOG1269">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4310724at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003838">
        <property type="term" value="F:sterol 24-C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000334">
        <property type="entry name" value="Methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030384">
        <property type="entry name" value="MeTrfase_SMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013705">
        <property type="entry name" value="Sterol_MeTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF1">
        <property type="entry name" value="HYPOTHETICAL LOC100005854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08498">
        <property type="entry name" value="Sterol_MT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51685">
        <property type="entry name" value="SAM_MT_ERG6_SMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase Erg6/SMT-type" evidence="7">
        <location>
            <begin position="56"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO02382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="353" mass="40138" checksum="6187FB4F98D8C3D2" modified="2014-11-26" version="1">MSAGAREIIPINLLRRRNKGEANEDVSAAADRFRGRFEKASLEERKAATTTMVNEYYDLVTDFYEYGWCQNFHFAPRYAGETFYESIARHEYFLAARGGFTENDHIVDIGCGVGGPARNIVRLTRCNITGVNNNDYQITRARRHDASAGMSDKIDYIKTDFCSMSFADNTFDGAYAIEATCHAKDKVKCYSEVFRVIKPGSCFVLYEWCMTDKYNPDDEYHRKIKHRIELGDGLPEMETAKQVVEYMKRAGFMVEEVIDVINQFESSPIKSIPWYQPLTGSYSSLKGVRSTPMGRVFTNIMCRVLEFLRLAPKGTHKATEILEEAAESLAIGGRLGIFTPSLYIRARKPLKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SKQ7</accession>
    <name>A0A088SKQ7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Membrane-bound acid phosphatase 2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_352650</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703202.1">
        <property type="nucleotide sequence ID" value="XM_010704900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SKQ7"/>
    <dbReference type="GeneID" id="22579294"/>
    <dbReference type="KEGG" id="lpan:LPMP_352650"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350033600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_352650"/>
    <dbReference type="eggNOG" id="KOG3720">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="258392at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF110">
        <property type="entry name" value="2-PHOSPHOXYLOSE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839496" evidence="4">
        <location>
            <begin position="28"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="515"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO02402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="578" mass="63636" checksum="1A6CBD81C2856AAD" modified="2014-11-26" version="1">MACFARLGLATVLAAALIACAISSVYAQSAINNDSAVAAEDILKVLQVQVLHRHGARSGLPRENTTKICTESPCGYLSWAGVEMLLKVGGFLRSRYNSDPSVVSSPMFESPNYNLDVAYSRSTDVLRTLQSAEAFLRGFFPNMDSLYAAIHTVPESADVLLNSNTQPWLKFFYSNNKRLLREVCNPRTDELFPDWREITKIGAEIYQEGFCSDYETRSDCARTLFDIGAAKKAIGELSQYPLLEANFEKLKSITTVLFDYEYHYNHSDPLMFKQGGRGQPFAQQMVTNMEGVMAGSNTYRLMHYSAHDTSLGPVWGTLGDRTPDGMMPPFAQVLVAELLQNTTTGAHYVRILRGCPGQSPDTKFDFAWNSEWQMQCMDALGIAYKAKENICPFADFKRFVKWSEPADVRGYCYLDQASIDIANCPSETVVYGTPSSVLVPSTCQFYRSACPQFACGMGYTLNSVSMQCVCSKGSCLDSNTTSGGTTGRESYAGAAVNTDEKIVTLRDSNGLSAGAVASVSLATFCVGAIIAAAATAAVCMHTTRRWHYQCMHMRSAVTERNQLRAEREEPTKNLVEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A559</accession>
    <name>A0AC62A559_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histone H2A, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2120070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="XUY36877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="132" mass="14131" checksum="AA172C2797451F2B" modified="2026-01-28" version="1">MATPRSAKKASRKSGSRSTKAGLIFPVGRVGSLLRRGQYARRVSASGAVYMAAVVEYLTAELLELSVKAAAQSPKKPHRLTPRIMMTAVRHDEDLNSLLKHVTLARSGVVPSLHKAITKKKGGKKSKATPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A566</accession>
    <name>A0AC62A566_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Membrane-bound acid phosphatase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2820080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="XUY36924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="548" mass="59178" checksum="74AEF841810752C9" modified="2026-01-28" version="1">MPAVLRSPLPRSVRRMAVLAAATALLAAVCLPAPARGSVEWVLQQVQVLHRHGSRSAVPSYNATDICGSTPCGELNPEGETMVRNVGEFLRARYTADATVVDAPFLPSSDYDLSVVASRSTDVRRTLQSAQLLLAGMFPNAIRLIPAIHTVPTSQDTMLYTFSQPWVALYATYATAAQQARTNPVVDHYFPDWTELRGLAAEVWSEGYCSNYETRLNCAIMLFDIAAAKRSVGKLPAAVAARYDDLHAIIAEWFRGMWHYDASNPFLVQQGGRGQPFLQQVLTNMDDFIAARSTYKVMHYSGHDISLAAVWGTLGDRSAYAMQPTYAQTFVLELLKSATTGEYGVRVLRGWPGQTPDTGFTFSWDPTWQLRCRGRDETNYAATDNLCPLEDFRRYVTWTVGTDPRGMCLLDVATSAVLNCPTAEAEQTVGVALSESCSLYRAVCPQYACAPGYVLSASESRCTCASAACLVSRGSEGKANVSVTVSMPGVSRGTAAGIAMATFSAGALLAVLMTLIALVLLRCSGGSARYSGPCGKCVARGEPTREAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A572</accession>
    <name>A0AC62A572_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CAAX prenyl protease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2420030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="XUY36892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="285" mass="31604" checksum="48DC442F170B2735" modified="2026-01-28" version="1">MDLLLCAGASAAFISTFYVWPRERRFISSSINSLGGASLDPTVYVDRNSDEAIRRRTISLGFSCVVSGVYLAFGTASSFTLERQSSWLRPVIRSLFSTLLLFAGPIAEMCYLRTFEAPDRALQLWRNYVICPMGEELFYRGVLFSLLHRRSSAVRIGVSAVLFALSHIHHLVSLASDAYRRCEDNETDRKDLDGRERACWRSAGRTICGVFVFTTLFGLLGGYYYEHVCEGSIIAIAAAHALCNIIGPPELTVLRGSQFTAFEKAASATLYVAGVVGWAWTLLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A599</accession>
    <name>A0AC62A599_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1120020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="XUY36965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="565" mass="56706" checksum="F017638C0CC61C9E" modified="2026-01-28" version="1">MTTLVLCDGSEGSLRAIELACAGNANPSSPISPGEASLILAHVWDTSATRRGTTNADSSSMDTRASRRSTCSGAAAPSASAGAGGHGGGVTACGDVLTTTLRYIHANKYLKNKLHYRMETACASAVCVGGGAGGSVSPEAAGDQTGGAAALQAARGKAEHAQKRSSCWSGGSGAGAAGHRSDQRPLQRQTDLATVVPGGVSSGAGSGTAPEGQHAAICTPENEMRAVAVVKYAAARAAHHHATAILLGVGQRQDGKVCVVGAVARRVLLELRGAYALHYVKEGGVRLRPGLAAATPLRFTIVVSVPADAPWGSAAVTQTSPGDEEAAPQTTALIATPPAPPPQVPKHVQEAVAAAAQYVQTRWVCPHPAPQVGQITFAVVATSSSQGGDGTAEPDRGENGGEAASGLDAAGWQGGLTWVSPLESYRRYLEALPGIKCNPGSPTNAAASSLFPTSSINPASVSEADAIETQQPEHAAAAAGAGGSGATAPAPQAATSPVTVCALKASKKAPHLSLDAAPEVALPQIVKQVCALKPHMLVMPTSLVPESLQLALLATSNPHCVVLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5C6</accession>
    <name>A0AC62A5C6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha tubulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1320070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="XUY36978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="451" mass="49683" checksum="3D47FCCC1FBC5BF5" modified="2026-01-28" version="1">MREAICIHIGQAGCQVGNACWELFCLEHGIQPDGSMPSDKCIGVEDDAFNTFFSETGAGKHVPRSLFLDLEPTVVDEVRTGTYRQLFNPEQLVSGKEDAANNYARGHYTIGKEIVDLALDRIRKLADNCTGLQGFMVFHAVGGGTGSGLGALLLERLSVDYGKKSKLGYTVYPSPQVSTAVVEPYNCVLSTHSLLEHTDVATMLDNEAIYDLTRRSLDIERPSYTNVNRLIGQVVSSLTASLRFDGALNVDLTEFQTNLVPYPRIHFVLTSYAPVVSAEKAYHEQLSVADITNSVFEPAGMLTKCDPRHGKYMSCCLMYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKCGINYQPPTVVPGGDLAKVQRAVCMIANSTAIAEVFARIDHKFDLMYSKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGAESADDAGEEDVEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5H4</accession>
    <name>A0AC62A5H4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histone H3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1620270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="XUY37038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="66" mass="7238" checksum="D87F239EB5F19D1A" modified="2026-01-28" version="1">MPCARCRACRRRGGPALPEQRDPGDPGGVRCVADGCHEPGQHPREACVTVRPKDVQLAVRLRGERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5N9</accession>
    <name>A0AC62A5N9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Elongation factor 1-alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1720140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="XUY37104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="449" mass="49058" checksum="C7CA18E3C4A6A3F4" modified="2026-01-28" version="1">MGKDKVHMNLVVVGHVDAGKSTATGHLIYKCGGIDKRTIEKFEKEAAEMGKASFKYAWVLDKLKAERERGITIDIALWKFESPKSVFTIIDAPGHRDFIKNMITGTSQADAAILMIDSTQGGFEAGISKDGQTREHALLAFTLGVKQMVVCCNKMDDKTVQYSQSRYEEISKEVGAYLKRVGYNPEKVRFIPISGWQGDNMIDKSESMAWYKGPTLLDALDMLEAPVRPVDKPLRLPLQDVYKIGGIGTVPVGRVETGIMKPGDVVTFAPANVTTEVKSIEMHHEQLAEAVPGDNVGFNVKNVSVKDIRRGNVCGNSKNDPPKEAADFTAQVIVLNHPGQISNGYAPVLDCHTSHIACRFADIESKIDRRSGKELEKNPKAIKSGDAAIVKMVPQKPMCVEVFNDYPPLGRFAVRDMRQTVAVGIIKAVSKKDGSAGKVTKAAAKAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5R6</accession>
    <name>A0AC62A5R6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histone H3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1620190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="XUY37030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="66" mass="7238" checksum="D87F239EB5F19D1A" modified="2026-01-28" version="1">MPCARCRACRRRGGPALPEQRDPGDPGGVRCVADGCHEPGQHPREACVTVRPKDVQLAVRLRGERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5X9</accession>
    <name>A0AC62A5X9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">D-isomer specific 2-hydroxyacid dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2020560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="213" mass="24157" checksum="D81C5700B25F675A" modified="2026-01-28" version="1">MLYFNRFPWRLVASKNEKKWNRFNCIELRRQKMVIIGYGDIGQACGEKATALGMEVTGIRRSGDNKADKFGVMVRGNDALDESIREADFVVGVLPGTHDTKHFFNKEFFAKMKPSAVFINIGRGMSQCEADVAEALNKGIIRGAALDVFEVEPLPKDSLLWEVPDCKLLITPHCGNLTENVIERTMEIFMDIFEEFFTHSRISAHTVCLKRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A669</accession>
    <name>A0AC62A669_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amastin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2020360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="218" mass="24268" checksum="570A0E723AA7162C" modified="2026-01-28" version="1">MEWNIPILLYAIVQVIAFVLVLFGTPIDMYRFRPRYIRPNATVTTLWGVKKGAFNSTNLMTSDYLWRRCTGRRDRFRLAQAFAVISIFVYGAAAALGFIMLYCCSFFRMVCLALNIVGAVTLCIVWAAVAVTYHIEDNEFCRKESVFSTYGAGFVLLLLAWLLDLFNIVVLLLPISIAAGGAGGSSSKDSKKQDESSNDHSRESSMEGSRQNDLSEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RH38</accession>
    <name>A0A088RH38_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_010580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009370">
        <property type="protein sequence ID" value="AIN95158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696700.1">
        <property type="nucleotide sequence ID" value="XM_010698398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RH38"/>
    <dbReference type="GeneID" id="22571787"/>
    <dbReference type="KEGG" id="lpan:LPMP_010580"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_010005500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_010580"/>
    <dbReference type="eggNOG" id="ENOG502QQR6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="278519at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="315"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="959" mass="100295" checksum="CF405E2C34A1D2CE" modified="2014-11-26" version="1">MSSASKPTGSGSSVTDPLTPLAAASLSSPPAPKLSTPPVAATAAIPSEPATAAVTADNDGAEAQPQRRGWEAVRDGRFRIALTHHYAISDDHTDAAPSTSTDAVQAEHATDAAAALGDKEGRALMCDTPGSEFCATEPHIEVSLEASLVNAINSAYTSTGYPFVVTTGNARGSVYGSFVDLSNPSLGSLELPPSQSIIVAPREASDPGSTPAHDLIEMDTLLAIRWGRGDGIMKTAGTAVPVAAAHGKHTQTAAPTGAAGSPHSPAVARTIAHHLSQYPEGIHGINSSPVLRQILVEGTLPTTLASTPSAPVNTAAQAPASSSAEANVPPLPTSPQSNAPVQHTLVSASTFNHVSVYLVAHQDGKLLYTAPIQSLSASIATRKVTAHQLILVGREEVDMLVTDPFTPPRTMPPKRTRIGFADISVAGEEAAIFFRSKTSRFVDADPGMKTISAAPIRFTVEPHLLLGNQNGDIFVFSLLQERIVQHINYNAGKPNVSAAIASGSNGVGSKLICSPVSCIAEIQNGIEKKITCMVEHAALAKRDRRRSFSTDDITTGLPAATNAAAPSYYDNDVPPSLYAVGFDDGQMLLVCVTCEGGWLLRHFNNQYFGVRPIHSIAVRVPPFYARLWTSHLPPITTAPHGRKRSTNESTGAPVPITTLVTATAALIVLEEHQLIAAISCSGGAIALVRLPGMEIIYSVDPTDYNAVGEILALQWMATMPDHLLTPDILVASGEDDTMTAFQLLEQFLVSAVEGNHHNGNDSVPHLSFTESVVANGRLRILEKKRFHRSWVNRLNLIPVAVPAATANAKVTSRSSSSSSSSGGGGGGGMPQYLGVCLVASSYDHLTSFWPYMFSRQGQGAGAEDGPDSTSAAVLAGCVGGASSREYAGTMRMSFPGGSLPLGRIAAPDRYVLVDGPTTAYPLHSELVIGVAAAGGGTSFFLATVCCRGKVKFWSVQVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHF3</accession>
    <name>A0A088RHF3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_030780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009372">
        <property type="protein sequence ID" value="AIN95313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701021.1">
        <property type="nucleotide sequence ID" value="XM_010702719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHF3"/>
    <dbReference type="GeneID" id="22571944"/>
    <dbReference type="KEGG" id="lpan:LPMP_030780"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_030012500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_030780"/>
    <dbReference type="eggNOG" id="ENOG502QW21">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275730at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN95313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="337" mass="39170" checksum="FC4AC35E54248EEB" modified="2014-11-26" version="1">MRVYSSGPPSIYLRHAFLHQDRLIRCFLGALEAVPLPSLPRMLLAEGFQRMLEGDAPQRELRELFEDAEVECRKTLLQMGVNEDGRRAHHDPRDREAWHAVTHDPLRRLLAYELRAACSYYARLMAVSSNPYVSAAVGVRTIIASDVRTDNFLVKMTLKFDRHPRNVETGERLGEAMPLVVEELMKELLLLERDAFGCFRFDPRGDNHHLVHSLKLADMTKTPQSYSIMLDPLMKRYANYCIERKEVHKGRWNQYKVHCGPEDHRIDQVLPPFESVVAKDPITGGALNMIVHYDEPICLRHKQSSREEKGNFGHTEVFELAIEQKNRTFWERHFLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHI4</accession>
    <name>A0A088RHI4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Intracellular trafficking membrane transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_020250</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009371">
        <property type="protein sequence ID" value="AIN95205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698170.1">
        <property type="nucleotide sequence ID" value="XM_010699868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHI4"/>
    <dbReference type="GeneID" id="22571835"/>
    <dbReference type="KEGG" id="lpan:LPMP_020250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000014500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_020250"/>
    <dbReference type="eggNOG" id="ENOG502SGN4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="438495at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046964">
        <property type="term" value="F:3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF8">
        <property type="entry name" value="ADENOSINE 3'-PHOSPHO 5'-PHOSPHOSULFATE TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="764"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="883"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="943"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="137"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="305"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="352"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="714"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="720"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN95205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="986" mass="105805" checksum="423B2600527233A3" modified="2014-11-26" version="1">MSRGHCLSPSASGASHEAMPPPPPGVQQVSPSSCLSPPAWSPPPRQPTTQRLCVLAAGVLIFHVLTSTLQEMIFHLPNFTNLLLLSCGETFCTTVLVGLLLVWDWCHPLPGRADPEHRGPHGRSAATAVTKITAEVTPQEPLSKSAPTVGDSSNTQGRCSGNAVSRSPDPFCDSEHQPPRQQRPFARGDGRGAFLSVVDGLPEAAAARADAVDCGNGSALTAVAARCPSPTRCASWYSTICHVLHPSTVSLRWYVCIAILFSCSLHLTNRTSFLLSYPLQVIFKSSKLLCMVVVHRFGVHDSHEAAASVSKDEAGSDNDDPRSSGHQWSTTAASAQHDGVFHAESDSGLLAGAKAPDASERHPCDEPQHRGHRDSSSSSPPLGLSTVVAVNVPIPAGRAFASSHPLDDDQQRSRWGALHSSGPRRRSWRWWWSRLWNQHCNDGVSRWCPARVWARVSSLAQCCASRPTTLPIDEWGHSQAVVGLRQRLSYHGGVYGGYSAVEVWCAAAARLVWWLQRLLRDTEMMACIAIVVGLISFTYASHLDMHVAAGHQSSKEGLAALAKAVSAEAAAEQHILAERLRGSAGASLAGSYSVASDVAAPVNTTGLAQPGAPLPLPPPSLPASSPSLFHGITAAVFRLSAPWMVTLIGVVGVLMSNTLDCIIYVLEEVHCFHATARSSRGYNRRVLRQHERVAEGRAPLLAGVQRKAVPLRHHASHRPPFSPSPPLSSSPPRTAVTAPSDLHPVSSTSMTELPELIPASPQELLFMVNGIATLLYIGGVIALWLHDCLLLFICRFTSSNAVATATGLHGGVGDFVSATVAGLPAARERLVVPTRPAGSAALPGEFSSLMDREEQQLQRLASLSGWPPWKTPSAPQRPSATEFPLSLCIILIVLASLTSLIGTLCLLRIIAEFTGVMAVVVTSVRKALTVLLSFLLYHRRFTLLHGVGLVGVVGGAVWYELQQRRRRGVCRREEERSGQVCRRSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHU9</accession>
    <name>A0A088RHU9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATPase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_051060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AFG1 ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="AIN95547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703869.1">
        <property type="nucleotide sequence ID" value="XM_010705567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHU9"/>
    <dbReference type="GeneID" id="22572184"/>
    <dbReference type="KEGG" id="lpan:LPMP_051060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_050014700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_051060"/>
    <dbReference type="eggNOG" id="KOG2383">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="548867at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040713">
        <property type="entry name" value="ZapE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169:SF6">
        <property type="entry name" value="AFG1-LIKE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="ATPASE N2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN95547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="478" mass="55408" checksum="06560742BD498802" modified="2014-11-26" version="1">MFRRAFFFLSLRPSEGYRQLLLRGDISNDENQVSALPVFDRLHDDLVKYAKDSKSTAVPKRRVELRPPNRLGIIPSFFLRREQEKKVEQAISDDNKAVYHPLSHVKGLYVWGGVGCGKTMLMDLLYDNAPPEIRKRRLHFHQFMLDMQKTSKLIRYKSKEEMQDPTHRSNMVSYNVRDDLRRTPDAEINLFDEVAQRMISDVDLLCFDEVAVSDVAHAMILKRLFHSFYKIGLVVIFTSNRPVDDLYKDGLNRGGFIPFIDLVKKQCIIHHMKSNIDHRLLGHQADTYLTPMNDENHSKFEKLFLEMCKAMPATERKLEVFGRDVIVPRACGGVCYFHFLELCGGEKSTADYEVIARAFHTIFINGVPQFPYENSDVKNRFLLLIDTLYEHKCKVMIHAAVELLQLQAPRGEAAGRIEGDAPRFDSLSEFERESGNKLMDADDSAFQMDRCVSRLFEMRTKEYLEIPHEQQDVDLSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHZ3</accession>
    <name>A0A088RHZ3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pescadillo homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_040760</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the pescadillo family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="AIN95400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703722.1">
        <property type="nucleotide sequence ID" value="XM_010705420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHZ3"/>
    <dbReference type="GeneID" id="22572035"/>
    <dbReference type="KEGG" id="lpan:LPMP_040760"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040013800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_040760"/>
    <dbReference type="eggNOG" id="KOG2481">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264910at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17709">
        <property type="entry name" value="BRCT_pescadillo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000108">
        <property type="entry name" value="Pescadillo homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03028">
        <property type="entry name" value="Pescadillo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010613">
        <property type="entry name" value="PES"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221">
        <property type="entry name" value="PESCADILLO - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221:SF6">
        <property type="entry name" value="PESCADILLO HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06732">
        <property type="entry name" value="Pescadillo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="BRCT" evidence="7">
        <location>
            <begin position="316"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="554"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="643"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="644"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN95400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="670" mass="77267" checksum="30AF8A40AD541CA2" modified="2014-11-26" version="1">MAHKKQAWAKRVKKERFKKKYLTRMQATRLLQMESIQFRRLCILKGVYPRALTRSKQKQSGNEKQYYLAREIKWLVRDHIAEKMMTYRAWEKKVKRAEAMGRADDLKALQSSRVKPRHSLVATIKERYPYFIDAIRDVDDAMSMIHMYAFLSPEIKSESTIEIHHSLTSGLSEKAKEMCHRWNRYIARAHVLTKGFISIKGYYYEAIIKGERVRWLCPHEYAHRFPPGIQQYVMLSFLEFYLEMMKFVLFKLESDLARDEADRLAIEDEEGLTRANAEDFASGAALAVLDVGANQAQAKVKEAESKRSLMEEELLKVRELFRGLTFYISREVPAKHFALIINACGGRVATDYVASNITHVVVDRPALPPGWQQHDQMEYVQPQYIFDCLNARQMLPVTGYRIGEDLPPHVSPFSVSITNSAEDNAAVEQVKKDHPRIVGYVPARVHEIRKLINPSYSPVDPEGKVAQLEDEYSDEEMHVAVPEMDMEDDVSLSGDELAEARKKPGWQEEEVTEEVQRPKLSAFKVKKQREMNLMNAPTNEVVARRRQALRKAQEKLRQSETPEARLQRKMSDVKRQEAVTRKMQLQVARKKAARFYKMVSGVVQGTAKKAATLEAKAKHIAEGKLHKTEDGKGLVNARLAARRQRAEAKGKKLKEKKADNPYKKLPKWVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RI39</accession>
    <name>A0A088RI39_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LPMP_050140</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="AIN95455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703777.1">
        <property type="nucleotide sequence ID" value="XM_010705475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RI39"/>
    <dbReference type="GeneID" id="22572092"/>
    <dbReference type="KEGG" id="lpan:LPMP_050140"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_050006400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_050140"/>
    <dbReference type="eggNOG" id="KOG0331">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4255at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000911">
        <property type="entry name" value="Nucleolar RNA helicase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002414">
        <property type="entry name" value="Nucleolar RNA helicase II, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059027">
        <property type="entry name" value="DD_DDX21-DDX50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012562">
        <property type="entry name" value="GUCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26142">
        <property type="entry name" value="DD_DDX21-DDX50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08152">
        <property type="entry name" value="GUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="86"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="117"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="332"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="668"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="86"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AIN95455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="689" mass="74779" checksum="3D829F64B1974959" modified="2014-11-26" version="1">MPRRAREESDEAKPHHTTKFTNSSDDDEPVKVSKTHTKASDHHNDIAAEKRQRTDESSKVAAAAAVTRAEVKDGEMPNNGCAATARPFSEFEMNPIVVKALQSRGIESMFPVQALTFNAIMRNTDVLVQARTGSGKTLAFGIPIVERLLKLQSHLTRGRGPAAVIFCPTRELAIQVQDVLCGISCGLIVTALYGGVAYANQERVLRSGVDIVVATPGRAKDFLEKGTLHFDRVVMACLDEADHMLDIGFKDDIELLLSQVAEQNGSTNAEKTVHQTLLFSATVPEWVHTCSFIAKDKEFIDMVGKEAVRTASTIKFYRRKCNFSEISSMLADLIKVYSGAHGRTLVFTNTKKDCHDLSINNTKLDSQCLHGDMQQEQRESTMKSFRDNKFSVLIATDVAARGLDLPMVDLVIQCAPPSDIDAFIHRAGRTGRAGRKGVCVLLYQPREEYVVERIERHAKMKFDVLPAPTREEILKAVARDAAEDLARVERRATNLFMEQAAELLKDADPVEILASALAVMSGYTSNITTRGLITGTPGYVTVQMTSDRPLPIPVYCSILRNNLGDDTFMRCRDITLLQDDPGCVFDVLEQFAEGVMNTPMRGITFQRIESLPPIIARELNSSRGGRGGFGNGGGYGGGRGGGRGGFSNGGGYGGGRGGGRGGYSNGGGYGGGRGGGRGGGRGGGFQRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RI75</accession>
    <name>A0A088RI75_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_060390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703920.1">
        <property type="nucleotide sequence ID" value="XM_010705618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RI75"/>
    <dbReference type="GeneID" id="22572245"/>
    <dbReference type="KEGG" id="lpan:LPMP_060390"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000023300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_060390"/>
    <dbReference type="eggNOG" id="ENOG502S7H1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265074at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN95598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="189" mass="20188" checksum="3DA0BB4CFC78A62A" modified="2014-11-26" version="1">MSHMTADLEYFKCDMCGVYLHRDIFCDHRRDCHGLGSTQLKRGECQRLAEALGRETRKLLLNKDGGDMRATSSSRGRAHPQTNVACTTTLAAGACKGVEARAESTMDAEGAAVTSSGQALLSSSVSVSSVSAGGVVPISATLSTEAMEKRQEARTRRTVSDRYQAGLDAKLSLLLTEDKKAALLGFLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIJ1</accession>
    <name>A0A088RIJ1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AP-2 complex subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_070070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <location evidence="5">Coated pit</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009376">
        <property type="protein sequence ID" value="AIN95693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704015.1">
        <property type="nucleotide sequence ID" value="XM_010705713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIJ1"/>
    <dbReference type="GeneID" id="22572342"/>
    <dbReference type="KEGG" id="lpan:LPMP_070070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_070005500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_070070"/>
    <dbReference type="eggNOG" id="KOG1077">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017104">
        <property type="entry name" value="AP2_complex_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037091">
        <property type="entry name" value="AP2_complex_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="7">
        <location>
            <begin position="23"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="4"/>
            <end position="5"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="51"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR037091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037091-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN95693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="960" mass="107462" checksum="392E9C836710EAF7" modified="2014-11-26" version="1">MDMRGLAHFIQDIRRATGNKKEEESRVDEELAKIRAKFIHTSSMTTYDRKKYVCKLLFISMLGYPITFGHMEGLKLMSEESLSAKLIGYLSTSVLLNENSDLLMLTTHTVYRDLLSMFDLSRSLALSAVANTGSRDFVEVMHEGVFSIVVDDTVNQHIRKKALLTLLHIYRKHPDIVDLNAVVPKAAELLLSTQDGVSMCAVTFLNGCISKETKHLYRGIPDKLIQVLARIILEKQTEPGYVYYGVPAPWLQAKLLRLLQYFPLPSDADQRNRIILVLRKVVKATDKVLKDAQTQQKQRGTKSRVSAMNAVLFEVVSLCIQWDVGSKLILECVALVTSFLSDKREANLRYMGLILLARLSFVDVPGFNFHMHCRQYQQQIIVSLHDSDPSIRKKALDVLVAMCNQSTTDDIINELISHLPIAADPNFKTSLVLSIALLAEKYCQDYNTYVDIMLTVVSQAGDLCPPDIAHRVVQVVVNDPSVQKRAANMVFEELRKTTKVSEVMLCVAAFVLGEFGYQIALNAESTPIVQLILLTQQLSFASVVTQSIIISTFFKFYTLYDDVAVRERIVKTLQAYTNSPHPELQQRATEFIALVEFARRELLEKVFEPMPPFRDDVNTVMNQVKRLHSGVQDIWGLKILERGVGDVNRTRKCKFKLESGDKHKEEKRAITLNDLSTMSTVPPVQGENTDQTNAELDDLLDVSLPPQDVDRVCSTYQEHRRRLFELSRADKGVLFSNESIELQCAKSTYGADTRMTVVVRDKTGQGLVQVAVEVIRAEPGLILQSRTKDGASVVAWGTITTEFAARSCFAFSSPPSVRVQYAPASDSAHVCTDALSLPILPTTFFTPYQVDSDANFSRLYETTKQASACAGWCKAMSPSTRVDTNTLMQLLELQGYRTKVTGSGAIVGVAAFAVQPKDCVEYVPVVCEIQTSAREMQVFVYSEDSVLQQGALDTIKFAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIK2</accession>
    <name>A0A088RIK2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein kinase, putative</fullName>
            <ecNumber evidence="10">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_060610</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="10"/>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703942.1">
        <property type="nucleotide sequence ID" value="XM_010705640.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22572267"/>
    <dbReference type="KEGG" id="lpan:LPMP_060610"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060011800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_060610"/>
    <dbReference type="eggNOG" id="KOG0198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273861at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001505">
        <property type="entry name" value="Protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000091">
        <property type="entry name" value="Protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000956">
        <property type="entry name" value="Protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF56">
        <property type="entry name" value="MAPKK KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="423"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="8">
        <location>
            <begin position="2369"/>
            <end position="2443"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="2589"/>
            <end position="2925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="663"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="884"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1097"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1172"/>
            <end position="1202"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1431"/>
            <end position="1487"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1504"/>
            <end position="1554"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1681"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1827"/>
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        </location>
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        <location>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="6">
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            <begin position="1967"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="2286"/>
            <end position="2295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2549"/>
            <end position="2565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="2928"/>
            <end position="2944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="2973"/>
            <end position="2990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="2991"/>
            <end position="3002"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="2618"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN95620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="3002" mass="313330" checksum="0ADBF3DB411E51F9" modified="2014-11-26" version="1">MQPPRLKPALVGTAGTADAAPPGAMVGTSLDYEGGSGKHENTEVNPCSYEEGDRDARVHSADHHGHPQRPVDMRDTTWRRSSPERQRSVLQLPTSAASLSFPPPAVAAPTSSSCSSTVDGAATDRSASVPLSPAYSGRFNNRVVGDYPPHNGTGSSWRGCGSSCVARADGSNERVRPGGDACGSGCSKFFLLRRFGAALLSTTAQTAPGCLLVLIGVVTGVLLFLPWSSNPVHITLMVLSAVVGCVCGLVYWHAERRWRHRCYDAHGAAAVYCSVGGAHRWHVQSSTSSAAARYRDHDASDEGSRDETSYWCCCSAGCACHFIDHQHFRIVLPTVQLLLLGIFVLVSPQVMATWTSTTASATELGGAAILADSGTGRETRYGARFYPVEVVWKTCLLHAWVGMGFSLPLLWALLVGLVHMAVLLAQFQHAGPGTLLTLVVWMSVPLLCLAIAMCIPRRRFAAMEERQQGQLLRVLPGGGEAAGYSTSYGAGAGAPLSLLASPSVGRSRDVFEDMYPPMYSPPSTVTAPASARAVQYHVHLSSPSVLPPPPVAAYSLASYPQAPSAMRAGGTYFARGTVGRYANLVRGGRMKMAAAQYDPIGLATPPDTSLALQHGQTRRASVCLYSPSSPSQAVPEVLDESAHDFIHAVGRMHYPTAFAAATLSSSGDGAHPSPPPPQASRRLAPYSRSPRASIGTRRTVPVRNVEPTPQQLQELRQQHKHKHMQAAQTRGAEEATALRTDAVDDDGAAVTITPAVLFPPELQQGRRSGSADTAAAAQAGAAAVSTAVDEGCASGVDGEAWYGGLPMPAGTSLEDACAPYLVLDSALVIVDVSWSLCSLLGTTVNDVMFRRLQDVLAWLDVVGREEVVKLVSSVVQPLHIAAGARRGQKRGAADHPTRKENAKTKARKDRHNTAEDDVRAENLKGHNAQAEAAKQLNNSPEKVVRDGVADGAPVRRVTLRGRCPNCVDSSGSPSESGTGRGSRRPLFAVCFDVWAERLDTPGVNVAGASSWTHPFSAGGGGQQSLAPHVIILRRPLLHGLCDALPLPVALVHPRTGEVLCWNRYAERLTGCSTYAMLGMSAYDSFVYEALPGAATAATSQGDFSSTGRQLPPPPPSPSVESTPSAHWQQRLPNRTALSAATEIGTVPNDEVASQVSALQLAKSASSTTVALLHPSQQTTPPTLSPLHGGAGRLSFAGQASPPQHAADLNDTFNAAALQQHRGAPLPGFFYVPYTRAAAGVAGVELALTSTSGDRGARLSSLSSTGGGPYWTSSPQLSWTLAGRGGTVGAAAGHADRLFSQSDAASQPSLFARVDVRGSGKEHNTSDTAVGAHCPRPPPPPPLAEGYQCATNAHDEAVIATAFEAGGNTEARGDGGDGDDDVRASPYRSVPAMVRGLLFRATLRPLRGALCCEEGGVVQNHLGGPLRTSARTVAGEHASGRGAEESPFLGQPPRTAHASDNTVLGGEDAGKEQASAPESNQAGGLINSGMADGAEVMLSGRHRERLQQRHHSLDRTAAGARERNRANEEDSGAEGELDMADNDDNDDPFDEHNFPNAMSAAINDGLMRAATLEQLFATKTMPCNFGLDRESPTWPRRSTASTGPATAMALVALLSSELMPQYSLREALQQLATSEAPLLLTLSEPPVYATACASAELLLQEQRLSHRRASSLAPVERGCYVSAPDSHLGTPHPPQPPLPRQQRPQVPALWGDGSASLQLVAAVKEAVESYRESIEEDSSGYTDLLGLLSLSGDSGGGCPTSGYAARNSPSFLEPTPIGDAPSTTVTTAITADAVRQLRLLKSLSDQLLQATAAYNRTRQPMSFATRELGGGVAGRMPPSSSSPSLSLGQLAAPAAPAADAAHVRYLNGRHPGSATTPSPYKAPPTSESLRVSAHQSPFQPPPPHSPLVLISDAAKGAHRRQKSGGPHRRQPDEPAASAGTSGSGTQTRIYRDPSGISSSVALKDATAVAPSAAGGNENAVLHEPPPPPHDDATHPRDTGSGVRSDMQDTGASTVKSRPRHAAKPSMTSVSRTSHAGAAHGTQDGAAASTPAPSTPFAPSDSAVGAGMKQRGTGYVGRISGGASFADSPHSGRGMGRTIGATPTATSPLNTSPFAVSAGFAPAMASLRPPAMGAGVSALDLATPQTELNSSPPRFDSVLFTGDDGESGRGGAGSEDVTAAVGFVHHSATSPCSWGHRLLSPSVAAAEMVEVEGSHGPDQRQQRPQPHKSPDAIFGAGSGSGATAARREPTSPRYRSSPGHRRESSLDILPGAPVASGSFSGNGGLVPTSNSASPPAGAGAGGQGTNSSSPHPARPGSSSLNANATAAATATAAVRLTPRRAGESAVWAVLVSRDEATIPSCCISVNLGEEFRLGRSSKCTTVVSDSFVSSTQFSIVRTAAASMTAQDSQSPGSGHGERGARRNKAFTVTLYDRSANGTYVNVKKLGKDKSCVLRDKALITFRLSTSQFFLGFVFILTDERGVPLDDRTGMVGDSGLRSLLDARLSPLPLTGRRNNGESTGGGGKESNSSQNTIMASPTVLSVSAARRNTPRALSTPDNSSFASGTPNGSRRAGGGAQRSSRHTHRETIEWKIGEEMLGKGGNAEVYLGINLTNGQLIAVKRVRLPTFAHSSDAEQDPEAKAILQQYRSLQEEISVLSKATHPNIVQYYGSSQNSTYFNILLEFVPGGSLRHLLDNFGALSPGVILSYVHQALEGLAYLHRHNIVHSDFKAANILITEKGKVKLTDFGTARLLNRPHATAAAAAAAAARSGGDAHSATSHTTSGRQKDDAVSAGAGGTLHVAGTLRWMDPALFHNAHSIGAADGAPAGAAKDSSDKLGGPTKAGDIWSVGCTMIEMMSGEAPWFEYDFESEEQIVNLLTYTAEPPETPECPECPDLVAIAQACLQMDPSRRPTCEELLCIVEEATARLQAQPMSSSVSPSREVSQQQLVTTGSMPGSGAGVRPNSATSTPQMEPGAGTAPATLAANPAAAYRPATDDRHRAERAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJP6</accession>
    <name>A0A088RJP6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_040750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="AIN95399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703721.1">
        <property type="nucleotide sequence ID" value="XM_010705419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJP6"/>
    <dbReference type="GeneID" id="22572034"/>
    <dbReference type="KEGG" id="lpan:LPMP_040750"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040013700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_040750"/>
    <dbReference type="eggNOG" id="ENOG502S045">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="278588at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN95399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="306" mass="34049" checksum="7B7842FA7D2AEAF6" modified="2014-11-26" version="1">MIDPSYDKARKPYVPIDTCSPGGTWVEERRYNHVRPTVTGAATAATETDARGASLRTAESLTAADRRPCRVLCGNWQEEDALERDLLAIQEAQQQLQQSRVDGEPLTSSSAPVQHMQTFLKSGWSPAATMEVITQKPNGIYTGGHTSTPYLTCDSRHPAMRDLKSTYRVDFSSTSSDVASLRRPDLGVRSQRLMEQTRAAAKEMQAANVRAHQEQLLLREASMKWMSRSSGPNISEYRATMCDENAVLPVVEELSQEYLSDEPITLYTGNPKTGKTMVVHGKTPVDPVSSSRFGKHSHFTEFKYAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJV7</accession>
    <name>A0A088RJV7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_100210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696743.1">
        <property type="nucleotide sequence ID" value="XM_010698441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJV7"/>
    <dbReference type="GeneID" id="22572757"/>
    <dbReference type="KEGG" id="lpan:LPMP_100210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100007300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_100210"/>
    <dbReference type="eggNOG" id="ENOG502SMHZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="260546at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039964">
        <property type="entry name" value="KIAA0040-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40382">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40382:SF1">
        <property type="entry name" value="RIKEN CDNA 4930523C07 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001838985" evidence="2">
        <location>
            <begin position="27"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="272" mass="29105" checksum="BAAA5B2BD96D3170" modified="2014-11-26" version="1">MAFRELTALAAVVAVTAMWVATSATAQAGQTCSDLSNPLANLDYSDAGVKACVVARCVATLNATPTTTSNGYCNGEPTSESSVPCYQLEVGYSAYYICLMRALQGTKTPGLIDVGAAATRFFNTPGFPYHLSLLGCYACNHFRLTVFPSLGSSCSNWTCGAVSSQSPSAPGYGQPDEGYNHRLCSTGCIAGIMMIPFTVAACAIFFACGCCWPSPLLKTTYKTMLEEEEEKYRKRFDENNPSNPVGLYYSGVNEPAPAANQKRHSEVVLEYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RK65</accession>
    <name>A0A088RK65_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cilia- and flagella-associated protein 45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_101060</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CFAP45 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696828.1">
        <property type="nucleotide sequence ID" value="XM_010698526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RK65"/>
    <dbReference type="GeneID" id="22572843"/>
    <dbReference type="KEGG" id="lpan:LPMP_101060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100017700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_101060"/>
    <dbReference type="eggNOG" id="ENOG502RNQJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1902038at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033253">
        <property type="entry name" value="CFAP45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043597">
        <property type="entry name" value="TPH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15504:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15504">
        <property type="entry name" value="NASOPHARYNGEAL EPITHELIUM SPECIFIC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13868">
        <property type="entry name" value="TPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="3 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trichohyalin-plectin-homology" evidence="10">
        <location>
            <begin position="121"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="102"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="181"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="357"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="413"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN96175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="480" mass="56829" checksum="5383664F54E53469" modified="2014-11-26" version="1">MTFFSSNPCDVFPPRRRGQSDGALRKELNARGAPRDSAIITKTELDIIRGMIDGRFLGSLGGTAATTAASRTHTGAAEEHRRRMQEFDAERTRNGAAPRTAEEIEQAQLRQLNLEKARLKLDEEYDEVKAMNRVIMEAKCVATREAQRLEKQKRVEEEAAYNRQMDALMAQEAERAQQVYLERERQRMEEQQRNAAMIKVQLHERDVERVRRLERHQQEQDAMSRHIELLQVEEKAEKLRRIEAARRLMEEAAIANAEQIALKKREREMLLEEERKMAEYIKQKEARDEAYAEEQARIRYEKEMEVARLRASQQRVQDKQAELEELRARRVQEAYIREERRKEKEAAERKNAMHADLQQARLAQVEERNRLKALEKAQEQEELDRMLAVQKISREQELERQARTRRLQEENSLALLKQMMEIEERRRRQRQEEIEEGNQIRKEARERQAALEAIRHRKLGELEELGVPEQYRRALLKVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKB5</accession>
    <name>A0A088RKB5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidine phosphatase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_130380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697120.1">
        <property type="nucleotide sequence ID" value="XM_010698818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKB5"/>
    <dbReference type="GeneID" id="22573148"/>
    <dbReference type="KEGG" id="lpan:LPMP_130380"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130007900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_130380"/>
    <dbReference type="eggNOG" id="KOG3734">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="414418at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051710">
        <property type="entry name" value="Phosphatase_SH3-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469:SF44">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="470" mass="52675" checksum="E81D0EBC2E5A2FE9" modified="2014-11-26" version="1">MLTAPQFAKSTKNIQSTARQQEEQLSDLFVLIRHGERQDHVDRTWKGNTLLPFYDPPLSNAGRKQSFETALKYFALRQERKVERRIRGMFTLFLVSPFHRCVETAAVINVIAFEGRLPMYVEPLLADWQQPKVFRTVPVLGGSYMTSGARSVPGAEGDRLLFRPQVEALRTTLIPFLKTRAAEETELLAEYNIGAEAASGWATLAEEWLRTHTALPVWTCAATASTIEAKVASQPDTAGEVRATSRRSAKSCHPSPPDTLNKGYRGCGVAHPEGKSDLVRRCEQLMGTHFLRRAGAESDAMVPLAIQTAVAAERRTRLPKYFQIWAERTVESRESAGPPALLPPMHVMAITHADVVSTLLEVCCPKYHDKGAGYSVPYCSVTTLQRHNNYYRIPTEEERQRREASAKTIAPAQKHGKYYAKKKFNMLPSNNQLMTPSLARPPSPLPVEWNVEAVGSTDLLRTRIMIQYTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKB8</accession>
    <name>A0A088RKB8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_120500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009381">
        <property type="protein sequence ID" value="AIN96378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697031.1">
        <property type="nucleotide sequence ID" value="XM_010698729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKB8"/>
    <dbReference type="GeneID" id="22573056"/>
    <dbReference type="KEGG" id="lpan:LPMP_120500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000046800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_120500"/>
    <dbReference type="eggNOG" id="ENOG502SKHI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="262473at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="254" mass="27182" checksum="23091EEB59907A77" modified="2014-11-26" version="1">MPHTDNAPLLFAEPPHPVDDNADCSNDEQIDPNDPHLGIMPDSLSCTLATPAGMQESEDVYDGSMPSTSAASTTMTALGCAAAPTLQASFTPGASTSITPAPVEAHSASGTLPFLQHRWVGNYDSGSRRLSFRGADRSTTASGYGLRLVGDDVEWLQGSFEDSTTSPREEVQPSWQHLQHQQPTDKSNAARAMPPTLSDAGASAVRKKAPEAHYHFERAVQSQPQRQTAYQSTDEEDSQAAAMLWAAQQMAALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKG0</accession>
    <name>A0A088RKG0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA (guanine(26)-N(2))-dimethyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.216</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_130830</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:43140"/>
            <dbReference type="Rhea" id="RHEA-COMP:10359"/>
            <dbReference type="Rhea" id="RHEA-COMP:10360"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74513"/>
            <dbReference type="EC" id="2.1.1.216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.216" evidence="7"/>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697165.1">
        <property type="nucleotide sequence ID" value="XM_010698863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKG0"/>
    <dbReference type="GeneID" id="22573193"/>
    <dbReference type="KEGG" id="lpan:LPMP_130830"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130012600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_130830"/>
    <dbReference type="eggNOG" id="KOG1253">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6349953at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160104">
        <property type="term" value="F:tRNA (guanine(26)-N2)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002940">
        <property type="term" value="P:tRNA N2-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:001098">
        <property type="entry name" value="N(2), N(2)-dimethylguanosine tRNA methyltransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.70:FF:000001">
        <property type="entry name" value="tRNA (guanine(26)-N(2))-dimethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.70">
        <property type="entry name" value="N2,N2-dimethylguanosine tRNA methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002905">
        <property type="entry name" value="Trm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042296">
        <property type="entry name" value="tRNA_met_Trm1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631">
        <property type="entry name" value="N 2 ,N 2 -DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631:SF3">
        <property type="entry name" value="TRNA (GUANINE(26)-N(2))-DIMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02005">
        <property type="entry name" value="TRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51626">
        <property type="entry name" value="SAM_MT_TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1 9" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="385"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="645"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="701"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="400"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="456"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="718"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN96512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="733" mass="79644" checksum="76BD49F1064F438E" modified="2014-11-26" version="1">MSVKSGQFNCDAVTRECPVGFSKITEGTTAVLEPPPNKKTSASSAAPAAAPLNLSDEEADGQQGSQAVFYNPAQVVNRDLSISVIELFSRLRLAEPRRRGGTKEGITILEALSATGLRAIRYYKEITNVRYIIANDMDADAVNCIVRNCAYNGVPVQYPTLKENMPSTAIELYADETETGKGELKSNVSPRVGVCAGGAILPNLDDANDLMFRLAMDSSAHPGKRVCLVDTPAEASSGPLLRPLLQQELMDVVDLDPYGSASPFLDGAFRCIKEGGLMLVTSTDSAILCGNFADTAHAKYSSMPYKASHCHEAAVRTLLACVERVANRQKKYIVPLLSLHIDFYVRCFFRVYRQPAEVKLSACKLGYQLQCSSCSAFWVRPMATVRQPRPSRQARHRQKHEMNNRQGRAGEKPANGDVEQQNEDETAESATVAPQEHHHSRHGAKRVRDDEDNDEAASHKDNGVRKEVYPASPSRHTNPKITPLTLQQMLNLAAATVSTASAPSRTAASACLVCGSNIVLSGPLYAAPTQNREFLEQLLALVEERAREGRLNAVARITGLIRTALEELPECPLFHLLPDVASYVRVRCPPTPCIVGALARLGYRCSQVHCAAAGLKTDCPPEVLYRVMLQWKAVQDALDLVGEAAVEDSGDNTEKKSPAASTAPRPLLVAPLTEADFTYDKDHDFRGRVIGVAKFVPNAPGWGPRRRHQGAAAVPEAVECHKDSGTDNRNGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLM6</accession>
    <name>A0A088RLM6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mannose-P-dolichol utilization defect 1 protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_141070</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the MPDU1 (TC 2.A.43.3) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697338.1">
        <property type="nucleotide sequence ID" value="XM_010699036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLM6"/>
    <dbReference type="GeneID" id="22573374"/>
    <dbReference type="KEGG" id="lpan:LPMP_141070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140015900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_141070"/>
    <dbReference type="eggNOG" id="KOG3211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271506at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016817">
        <property type="entry name" value="MannP-dilichol_defect-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 LEC35 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226:SF2">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023381">
        <property type="entry name" value="MannP-dilichol_defect-1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR023381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN96685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="230" mass="26017" checksum="8F655FF9B5298548" modified="2014-11-26" version="1">MSVESTMRYFVSNYLSYAVVVGASILKVPQILKVWQNNKAAGISLLSLFMELLSYIISTSWGVVRGLPFRDYGENFFITVQLIVLLLLVARLQKATRRASLVLATELLVLYMFASGQVPRTIHECALNGQVFFNMFSRVPQIYTNYQTRCRGQLSFLTFFLAFGGGVVRIMTTALNVSWEKGKMVMLIQFSVAAALNAIILAQMLYYGIAGRKSERENRRRTEAKSLKHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMD2</accession>
    <name>A0A088RMD2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_161350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN97010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697663.1">
        <property type="nucleotide sequence ID" value="XM_010699361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMD2"/>
    <dbReference type="GeneID" id="22573714"/>
    <dbReference type="KEGG" id="lpan:LPMP_161350"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160018900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_161350"/>
    <dbReference type="eggNOG" id="KOG2605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="246725at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF11">
        <property type="entry name" value="OTU DOMAIN-CONTAINING PROTEIN DDB_G0284757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="2">
        <location>
            <begin position="379"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="957" mass="102391" checksum="BF6EC65516AC44B8" modified="2014-11-26" version="1">MLNSLLNVPVPAMVRPLRMLGGGTPNSKDGRSGHRSSRQAQSPCSLPGFSSNKVNPRHTGPLADMVNTEARKSSVTPPPRPTITIFAELDKDDAQSGSMGFGNASRTTMKDYITRGAALQVDQDPLASTQTVLTPMGYSSLCQYANAEATAKMSTSFSNESAVVAGIRRKSGFLTSAGSNDSRENMDGTSLRPPSLADSSDLAAQRNSSFLSVLPTEKSWMHGRTSTYTGSEEAVHHPVRISATPVVPIVPHVAELLSRKRVVEDMQRLYGGAGGAAKSTAVDSASGSLQATVSAKTQNVSSVSSRTGSAAEASKSPAISNEKNSHHSLSTSFSSSPRKPGKGEKKAPLATGTDRQLAREQIIRVGVQRLYQRLSELRLVVYRVQNDGNCQFRAISHQLFGNENYHDIIRSQIVSYMRSARAESFDYYFESPAQADMYYDNLAKPGSWGDELSLRAASDCLYVNIHVLSSEERNCYITYRPSSDHAVSAPSFLVDVWKLRERRRAERRLLRTRGPQQQQPLQHAHRHAFGNLQQASSYTGFQDNTQGLGAATTTLPSDYRYPCRGGSSRSARGEHGKAAVDQRLLVPQGSAPGFSPRRQSMGNYENANRVKQDNDSDEEGEMDANAIQLALHRKLQQSEIRFSWPSSTMGSNNLGAVTPGSGGNVGNLSLEASTMPLLQHQSTAAPNQLEQAAAVPVPRLVSGNADASRGMATNQLEKFRAVGAEVQSLDAATQPVNIFTQSMETANTCGTDDVAVCFPRKPTSGATAPAASCSSLLQPQAQRSILTMTSGTIAETPLLGGTRQVDPIAAPPALSRTQRQGDEAGEVMLLASTTSRGPPNQVLQQSFSCLQSTTSAAGYADHFNTDTAQSCSPAILSPSSGGYGASSQLFGSFVPRTATPSFGLGADSDGNVQSGSDASAGVNPSVHCFSFEPRTEPIDIFLSYLYPLHYNSLSVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMI4</accession>
    <name>A0A088RMI4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cilia- and flagella-associated protein 206</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_170170</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CFAP206 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697708.1">
        <property type="nucleotide sequence ID" value="XM_010699406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMI4"/>
    <dbReference type="GeneID" id="22573760"/>
    <dbReference type="KEGG" id="lpan:LPMP_170170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170007100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_170170"/>
    <dbReference type="eggNOG" id="ENOG502QTGJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251073at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003356">
        <property type="term" value="P:regulation of cilium beat frequency"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021897">
        <property type="entry name" value="FAP206"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21442">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21442:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="495"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="503"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN97055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="710" mass="77376" checksum="2FFFF9EB61DB8178" modified="2014-11-26" version="1">MDVIPLVAQEVVSRYHKQAGDRPMSSAITLDLAALLTRLWLLKERDRLDSAGDVAASIPHIEALADDMLDYLLHRCSLPSLATLSLQVRCDTLCMSRKVQQHKAEVKKEAIRVQLEGALMSMEPEMASAEQVWGSLAVCFAHYYSDLGPVTSATVKADNGSSGTAHNETLSAVSSVLPRAQVAAFLCQDRVEQTCQLRQLRRITWGLRLYQKEMGRSAGMDLMSLSTSVDTPLAELEVKSAEAVAELEPRVNLTRALLVSSTCPLDAVAHQRLKEEYHHILLVQHVLRHVQCGLQHLRECMNNRVMQPYTLLLAELRQLLMPTSKVASAAVSSSANASAFDSSPTAVAAAAPGEAAPKKVVFPRFMELTDAYEAGMRCADELPLWAALLRAATESAAGYASTLPRVAAEDALALAEDAPAPPVTSASALAAEVTALLDSDTTRQRLPSGVHARYRADLPLHTVDPTVARVYPESLCGMRGYCPVQFLDGRPTSGLLLPGQAPSQSSSSSPSRTSLGCVEVSGSTSPAAMPRPLYFIFADAAAMRTFAADPWRYVEGCLHVFHAADPCLSLVMGRAGDLPRELYLEGSRVVERLTTDVENAQHAQGNRQDCGTQTGQIDAYIDHSYFWNEWDLRRHALKLANLMRMRTHSSQTAASHFRREAAMQADPHKDSATQTLHDAATQPPHVVHYLKGLRGTDTSAVEQVRKVVEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMJ8</accession>
    <name>A0A088RMJ8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_180760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697910.1">
        <property type="nucleotide sequence ID" value="XM_010699608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMJ8"/>
    <dbReference type="GeneID" id="22573966"/>
    <dbReference type="KEGG" id="lpan:LPMP_180760"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180010500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_180760"/>
    <dbReference type="eggNOG" id="ENOG502S9WW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="248409at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN97257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="110" mass="12496" checksum="F62130A85E10251D" modified="2014-11-26" version="1">MSSSAWASSSSAVGAEPEASALSSLRPNDRSYFYCAVCNTQFSDSYAAEAHKASRKHKKRSGELEWEKQQYKKDADVTPDDVWALVRRKQVELQVIAWSELKYSEEKSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMP9</accession>
    <name>A0A088RMP9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_130800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697162.1">
        <property type="nucleotide sequence ID" value="XM_010698860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMP9"/>
    <dbReference type="GeneID" id="22573190"/>
    <dbReference type="KEGG" id="lpan:LPMP_130800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130012300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_130800"/>
    <dbReference type="eggNOG" id="ENOG502S66N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052311">
        <property type="entry name" value="MMS22L-TONSL_complex_comp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46358">
        <property type="entry name" value="TONSOKU-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46358:SF1">
        <property type="entry name" value="TONSOKU-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="209"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="803"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="873"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="219"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="292"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="307"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="888"/>
            <end position="899"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN96509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="899" mass="94029" checksum="873BF4202807B836" modified="2014-11-26" version="1">MSTCEDEEPLDLTARGGGFGHTGVASLDTIIQSLNKRYEVYQRRRTAMTPFGTPGDPFIPAPPTPHPILGDSKMASGVSMNTGGVGGGGGVAAPQSSESPKESIIVPRAHPAPYWEERELYIVAEDLCCCLNGGINYRLLCEQNQRALEVLLTLVREDVQLCMSSELVLLPGGTVRPFLAKLKELLTESKRLLGEAGVSVPPRLANMIEQLPSSGGGASHASLHAGHNGAAVASAHRGGAPLSTTSTALHPGRSTLSASIMANGRLTGTSGGGGHPPGSAAAGGSIFEAAGSRSNHSGNLPSQYTQSHHSAPPHRSSPSAGLHGDSIRDGGVEGGNVAAAERRPSPAPPSRPHLVSPDNGYLHLGNPGSTNGNGLLRQPQPPVVSSFRHLSSAGACRNTPGLATTMDSLPVGCSGAGGEGASGVDVRSSHESGCSILRSGSGCLNSWLPGADLAPITKRKAFPIATDGRPPQRHAPPQPATTPMKQCAATESTSPVPTTLLSTGDVPGVHGHSHGVVSDNLVDSNSEAQMNTDVLAVKIPGEDAHDVLAAPAPGRRRRRQLEDLYGEFYAMDGMALLTDALGVVLTREYDQAASQQGEDAFAAFQRDVYAKVMPVLQSCESLQGCITDLEPLRSSYLASCLAHRVRPSGAVLERLKGIDEDRSVETLLLGGLHLGNRGLVALAESVLPRLYRLRRLDLSDNNVSDSALEPLLRSIRYHPSLEHLNLSHNPLTDGALPLLLRIAQTLPRLSELLLRSCAMKPAALQMVETEVRTPSTHAIPGEAGGLSLQPLTRVGSATVSATRTAAASALQPRPPSSLPRLTLPRGERRWSPMSMGRAESVPSGSSKGIDQSEKALKERLPIGMKVAQEPILPALATLSPNSLSDRSPPGRKDGAGDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMR1</accession>
    <name>A0A088RMR1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Vesicle transport protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_181570</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GOT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697990.1">
        <property type="nucleotide sequence ID" value="XM_010699688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMR1"/>
    <dbReference type="GeneID" id="22574047"/>
    <dbReference type="KEGG" id="lpan:LPMP_181570"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180018900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_181570"/>
    <dbReference type="eggNOG" id="KOG1743">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="204784at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045176">
        <property type="entry name" value="Got1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493">
        <property type="entry name" value="CGI-141-RELATED/LIPASE CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493:SF9">
        <property type="entry name" value="GOLGI TRANSPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN97337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="143" mass="15849" checksum="EB604B879E8B9B64" modified="2014-11-26" version="1">MDSLYSWDDSTKIGVAFTGLGVFFTFMGVLMFLDSILLTMGNVLFVVGVAMVMGPRRCKAFFIARQRASACFFTGILFVLFRWCFIGMCIQGFGALNLFGNFFPMLVRVLESAPIIGPILLSAPVQKVLSLMHINDGRSLRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RN56</accession>
    <name>A0A088RN56_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ATG8</name>
        <name evidence="7" type="ORF">LPMP_191510</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ATG8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698145.1">
        <property type="nucleotide sequence ID" value="XM_010699843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RN56"/>
    <dbReference type="GeneID" id="22574205"/>
    <dbReference type="KEGG" id="lpan:LPMP_191510"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190022700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_191510"/>
    <dbReference type="eggNOG" id="KOG1654">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6738456at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000309">
        <property type="entry name" value="Autophagy-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004241">
        <property type="entry name" value="Atg8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10969">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02991">
        <property type="entry name" value="ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="lipid moiety-binding region" description="Phosphatidylserine amidated glycine; alternate" evidence="5">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604241-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN97492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="120" mass="13451" checksum="B704D258F37B8EDD" modified="2014-11-26" version="1">MSSRVAGSYKKAHTLEARLRDAEKVRERAPDRILVICEKAENSPVPDLDKSKFLVPPDATVGGFLVSIRRRITMEAEKALFLFVGDSVPANSTLMSDLFNRYKDEDGFLYVTYSGENTYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNA5</accession>
    <name>A0A088RNA5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_141110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697342.1">
        <property type="nucleotide sequence ID" value="XM_010699040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNA5"/>
    <dbReference type="GeneID" id="22573378"/>
    <dbReference type="KEGG" id="lpan:LPMP_141110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140016700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_141110"/>
    <dbReference type="eggNOG" id="ENOG502S0HK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273650at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000567">
        <property type="entry name" value="Cold-shock DNA-binding domain containing protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="2">
        <location>
            <begin position="366"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="484" mass="51477" checksum="C0987171462C37CD" modified="2014-11-26" version="1">MGLSCALTSGLSLRGFSNTPARLGRSAGILHSSKLCFARFEARVPGKPHDASHSAVRLHGTVTAFKHRRGYGFVLAEGIAAPAHPLKRRYVALEPQAAATGDKDVKLQQDCLTSLGPAEAGKELPKCFFFTRSALLGGFYVTEGERVSFAVTPVRPGKGINRRVAGNSLRSRKNDGDHAVLASTDAAEFSLDSPEGGSEENSDASTRDTQSQANHIAVDLRYYDANTGKETPISPLTLYGKVVEWDAAEGLGMIAELDTRRQYHEDAPRFPFSSENVDLALGAELRPGRYVRFCLGPAAPVPSGGSEDFTATATTDAGASADVGEGVELEAQRVIIDASMERRKGAVGRPLILADAAPGTMTSESRFCGVVRELRADAFGFIQDDLSGESIFFHLSSASSRVKAGDRVTYVLREIEHGKHAGKKACYDVLVDQTAASRAPGVASDGGGAAAGAGDADGYHQRHAAERRSKVAHDEDDLDFELLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNI2</accession>
    <name>A0A088RNI2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridine nucleotide-disulfide oxidoreductase, putative</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_200060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698205.1">
        <property type="nucleotide sequence ID" value="XM_010699903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNI2"/>
    <dbReference type="GeneID" id="22574213"/>
    <dbReference type="KEGG" id="lpan:LPMP_200060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200006400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_200060"/>
    <dbReference type="eggNOG" id="KOG3851">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5376590at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070224">
        <property type="term" value="F:sulfide:quinone oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070221">
        <property type="term" value="P:sulfide oxidation, using sulfide:quinone oxidoreductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015904">
        <property type="entry name" value="Sulphide_quinone_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632:SF2">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="794" mass="86806" checksum="2B58928A0D111A2C" modified="2014-11-26" version="1">MRRTRLHRMYLPRVPKKDPNVHPLQVQSAQRFLRTAGAGAVLAVLLSAFLALRKTQQRSRLSEKELLRKRQGQHVVIVGGGAGGSALAALLANSAPDLRITVIEKDKQQVFLGHVPLAHVGHRSYDIATSTGVDVVRSPAAWNVTRDANLVAAEVLRVDPNAKKVYVRSTKAMLIAAAAPNEDDAGERRPSWGADLLSRYWPSRHPQVSTVSVNEDGSANLSDGTTVFSYDALVVAAGANRSLGSLVGQVQPAQLDTYRIAVNPGTTRDSLVNLFSGNVVHVKVPPASFVLQIEAARALTTPLRAASGSGVPSLELGVTVSPALCTPLPTAAPSTPSSSAARTPLSMPAPLARWYGTSRAAATSPETAGAALIPDEVAERLRGVSGLTATVSPLNTLAKWCMHYSSRQHDSTFVSSVNTIWKFLHYYNKLGLCQYTVVTADPQPIGPAPRAVNTVIERFWRERQLACQQPSGDFPERFHLLFHSYLAAVDTVTNVATLYDYLNNAEVRVPYSLLVLDLPLCAPSFVRQSGLHRTRYVEECVMPALQRGTGEAAAAPQLRKHPFLGKAKKELEAFFADEASFMDVNHETLQHRRYADIFALGDVAGVPSSKSYGAVYAQVPVVAHNIRQALANQRIQAQLESDLTEVSRTETSAAVTQAPALPKASAKYTGYSSFHVVMTTWRAMWPEMCYDAPQTELRCLSPPSSPADLAEAATKRELDVVAPLAHCDHHLWNSLAWRDLRGFLNGLFHELALYELMYFFIFSRGLWHSPSWFYVPTYSPIDGTPHVPTWRDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNS0</accession>
    <name>A0A088RNS0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_201060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698305.1">
        <property type="nucleotide sequence ID" value="XM_010700003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNS0"/>
    <dbReference type="GeneID" id="22574313"/>
    <dbReference type="KEGG" id="lpan:LPMP_201060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200015100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201060"/>
    <dbReference type="eggNOG" id="KOG2084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="62495at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052097">
        <property type="entry name" value="SET-MYND_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165:SF2">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="5">
        <location>
            <begin position="223"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN97598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="700" mass="77758" checksum="DC331A0A2304244B" modified="2014-11-26" version="1">MSFSNALTAASVPGADGAESKAPMTDQNSGDMYPFLQALQEDFPANGGELPIGELLMLLKERKSDVFVRLDEFFETARRVSGLDEAMALKWKEKGNTEYKRRQHQQAVLSYTNGLLCAEAPETLAVLLNNRSTVFFDEHRYADACVDADRAVQYQPTYWKAMQRRGRALVELGLEELGQKDMEASKQESSDAANSPEAMAKVFGETAGGMAATCLPPRARVNGEVRIERSAKGRGLVAVSQLTEGSVLEETPYAIVARTEALLSVCSYCLQRSTCLYHGDEYRQHHVKSRGFFCSPSCAKAAWEHYGQQESQHPFFLCCPNDALLAYRMILGMRAYPDLAELSASPELDPVTGNDFGVNHIRTLEGSFSRELQPNAAVGGCESIVAAIGFYVGALTEPEAEQLRKAQRQILLNAVDVTCTMQTTTSASAANSSMLLQTNTTVARLGKAVYAVGALFNHACDPNCYMSFEGNPQGSCARLIVRVIRRAMEGEELTVSYGGISRFSFHSMRHRLHTLRECYGFFCSCQSCRNQVDEPVLTAEKEKYIQASDYYQKGRRLVREGDYATAVTVLLQSYEIIMRYICPPPHPPQWMLIKTHDALAQAYFHLKQRDKCVQHLREALQLDIKIHKNENRVELINEHTRLAFLALSPAEKKSHVDKAVELLRRFYAPSSMLDLQIAYVESSLKATPDTPPAVAAAAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNV9</accession>
    <name>A0A088RNV9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Flagellar protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_202710</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the CEP41 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698474.1">
        <property type="nucleotide sequence ID" value="XM_010700172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNV9"/>
    <dbReference type="GeneID" id="22574481"/>
    <dbReference type="KEGG" id="lpan:LPMP_202710"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200032900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_202710"/>
    <dbReference type="eggNOG" id="ENOG502QR8A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="70250at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00158">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000123">
        <property type="entry name" value="Rhodanese-like domain containing protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051889">
        <property type="entry name" value="CEP41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44390">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 41 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44390:SF1">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 41 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rhodanese" evidence="12">
        <location>
            <begin position="104"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="215"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIN97767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="249" mass="27930" checksum="D4812D95751F1BE1" modified="2014-11-26" version="1">MSINPTIGDKDVLQRRTAANPKYNGVQAVVNSGMTIQLAQYMRNNKIKTKKQPGELFQRLHIDVIAAFLNRQEPKSVLEDGGFARPMDEYGGPENALDKPAISYLLLDCREVEHYEACHIKTALHYPKIKLHHSTNPFLPGMYAYKNKENKCIVLYDLEEEAVVSLANTMVQKGIENVAIIAGGLREFAQDYADYLTAQSPVPIIPRDLRLKRRADEATQARSDARTTMSHKPKSLSSSLARSARKGTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNY3</accession>
    <name>A0A088RNY3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein kinase, putative</fullName>
            <ecNumber evidence="7">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CRK</name>
        <name evidence="7" type="ORF">LPMP_160950</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="7"/>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN96969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697622.1">
        <property type="nucleotide sequence ID" value="XM_010699320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNY3"/>
    <dbReference type="GeneID" id="22573673"/>
    <dbReference type="KEGG" id="lpan:LPMP_160950"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160013800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_160950"/>
    <dbReference type="eggNOG" id="KOG0594">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276735at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000737">
        <property type="entry name" value="Protein kinase putative (CRK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF552">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 2 HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="7"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN96969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="466" mass="52022" checksum="4863F72263A53E30" modified="2014-11-26" version="1">MSTAGRYKHVVKLGEGTYGSVYKGTEIQTGKVVAFKRMVVTSDDEGVPGAAIREICLLKELRHDNVVDLFEVLFEPPKITMIFELCDCDLKRFMESRPKRLLDAEAEMRPILKQIFIGLEYLHSRNVVHRDMKPQNIFVNVRAPDFAALTASPSYHHHPQPPHFSGVPTSVGGDGQLTAGPSERSSLFTGAGGVSPWEAAAEAPTNKPNQLIVKIGDFGLARVEEIPVKKYSHEVVTLWYRSPDVLMGSALYSYPVDIWSMGAIFFEMATSKVLFCGRHEDDQLLRMFWLLGSPTRGTWPSMLSYPGTVERVERASRAAAERPDLRFGSDVHVQQQSSSSQSHNGTRAPDLLTQIAYKRFYHNLKVVQQREESARSSANTYQLPVELWFDRPLFNEYMSAVGLDSCVTAEGVELLRQCLQYEPSHRITAAAAVRHAYLHAVPVPTAGALDVLMTSLLQTMEACHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RP98</accession>
    <name>A0A088RP98_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_201360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698337.1">
        <property type="nucleotide sequence ID" value="XM_010700035.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22574345"/>
    <dbReference type="KEGG" id="lpan:LPMP_201360"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200018800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201360"/>
    <dbReference type="eggNOG" id="KOG1893">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="303066at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071260">
        <property type="term" value="P:cellular response to mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050982">
        <property type="term" value="P:detection of mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027272">
        <property type="entry name" value="Piezo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031334">
        <property type="entry name" value="Piezo_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056770">
        <property type="entry name" value="Piezo_THU9_anchor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13167">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13167:SF25">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12166">
        <property type="entry name" value="Piezo_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24874">
        <property type="entry name" value="Piezo_THU9_anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="363"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1017"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1062"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1095"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1131"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1225"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1268"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1296"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1448"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1746"/>
            <end position="1767"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo THU9 and anchor" evidence="4">
        <location>
            <begin position="1224"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo non-specific cation channel cap" evidence="3">
        <location>
            <begin position="1534"/>
            <end position="1836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="729"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN97630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1867" mass="203899" checksum="0C62153480E194E9" modified="2014-11-26" version="1">MSELPYAIANSAYLFLVLHLLFVLTVVWQSIVAATLLVAFFSFSCLESVTSGVPETRQQPHGSPNAEHVVVGSSTVDVQEKEDGGGTEVFVSAVHATRESPSLPREDRSSVVITSWMKRNDDLLSPAVDPSSNSREGEPCSDAGNTSAELYSPLRNGADDTIAYAGSALDMRNTERLIAENVHTEAGHDDEQMAVQHRRRDAPAPQSQVRVQSFYLAPRSGWVFATAVTSFATVCASGVLFGCLYTSEQADLSSADSTLPGWVTTPAAELFLTVCFGVPVDSPNAKRQFCWTAACLAVVSLTSWCLLLCRVLGRCAHEAHEAASLTVASSFVTSTSTWSRVRVWWNVAVRLLAGFVTSAPYSVVWVCVAGVGQATTLGLLSLAVAMTTVLLFSSRVGQVQRQRQGNPRQRLWSLYTCMLLFLWEVQVIVLLPSIQQSLKTTSVWAKHGRWLAAVGAVPATSHNSMPCWRIIAAIGLWWAGAEFVCYYGSVYGTSPVARFNGGRERRALLRRGLAQRDGKQWSDAIGQQRAAHGKLQELRLERDAYLFRSSRGSSGSGRRRTCAPQQHGTSWCGNHQYAQHDRQHMSGHAPFGTSVSHCCWLDRGHSQHLPSYLSSRSDSHEYYLTLLHNKPFPASNARVHGNNACGTADTLRSSPLYSNSSVYGCFPGRPVPWQYSEITSTLPSLTITESESTVGLIAATATVVLSESAAEPLKHHDSEVESSPYMWQGWSRAPTRSPGRRGVEGNEDDAGVRHRSCGAYSNGEHSVNRCALPLQHSCAHYPYAFSVASSGPRASHSRLSGVTYVDVSLRPNGSSGGSSNQCWPPMTCGMPPGASVADGASSFEEAAARQCLSLPPKDQARPEQMRAEYTTAPPTMTSDGGAQRTADACALVSSLLRSLRSRARLAAHKVLDLLGDYLQRHTAPLPAEVDDSAGGCPTGPRADAPHAQRQRCRQSMERMTKHSQAGFTSAALSTDAEGVTAPLGTLVGAPPSSTSHPETVHVRSLWKMLELCAVQHWPYLCALLMLVQFTVSGTAVNLVPSLASIVYALLQRPWPPLWYWRLQMLFSSFVFLVKSGARVYLLTMGPSVSLTTCRWLSLLVLRVDVAASAAPAAPLLSPLSSIMFGSEFHRYMWVDLALSGCVVAAVAIQWSIVYPDHCVLWRREGEGDAPVSVSAAVLTSVESTGAPAHERRHDSPYRGVAELCKICKRHLHCWNAHRCGAGADYYAAQLFFDGLSLVLFGCAYYAIVPEGAAISEGNLLHAVQQNHLPGIFVVTALGLVVVLFLERILYVLQALVAKYVLHFFLATVYHALYVLWHTVQESKRGRGATTSVATTASVSLLLAAKFASLWCSALQLRHGYALHRLHDPFTIKTDLLHWVGHVTFRAVPFLMELRVLLDWSFSATALKVQHWMLLEDIHHTVYRRYVDMHDLHYTSHHQGRSFPYLVRLYQGVFGFTVILLVLFFPLFWYSTFSPQVRASHVTAWSTEVTFARMSPVPLFSADSTVCPSSFHDVAALFGGGTVVRAEKLLRYAAATDTWQTAHVAPCSTRMWSYTPAALRELLDRLGKTTDAVTLVVRNRVTRDRASEPTMIAVDFEESYTLPPASQALLADALKAWHAADSADSADTTDYLASPWRTVVVPLPSLYAPYVLSSGTGISFFSGLDVGGVNCSLTLHRVGKYSGFSCLTCDEDGQRNTAKNTLATDAPTSPAGSSKIASAVEIDETSSPLAFVIVSKNVAIVQSSFSLIPSVGIIALYTSFVLVMSSYIRNSFAGDAHRVVLLQLANPEPVAELLRYLYLARSSANSGQVGDLVLEQLLFVELLDLLRSPERLLRLGGRRVDDYADSTYRQALFEATKRPFSLPEGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQ10</accession>
    <name>A0A088RQ10_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zinc-binding phosphatase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_205670</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN98058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698765.1">
        <property type="nucleotide sequence ID" value="XM_010700463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQ10"/>
    <dbReference type="GeneID" id="22574779"/>
    <dbReference type="KEGG" id="lpan:LPMP_205670"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200063900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_205670"/>
    <dbReference type="eggNOG" id="KOG4471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271628at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14507">
        <property type="entry name" value="PTP-MTM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF128">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3,5-BISPHOSPHATE 3-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="4">
        <location>
            <begin position="243"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="440"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="463"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="480"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="1">
        <location>
            <position position="645"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="581"/>
            <end position="582"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="645"/>
            <end position="651"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN98058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="992" mass="108556" checksum="EE4C97C0C3663AFA" modified="2014-11-26" version="1">MSCFPPFRTLEGEVLDLHVCSSIDARDAVALLYFCGGDEKACVVQPCSLALSQYQMHIGPLGREACVEVPYMLIATWGIARASSSATKAFVQVQQQAEEKARTSSGTAAISTTFTSGVASPASPSATAAVAIMTPLLSAPPAHVPQPVPLPSRPRYADPLPTLYVVTLQTKHVWQHRLIVQSERLLKNIRAHLTVVHCLALVSDLPAFHYAEERQRWQQQQQQQGGSAEEATGRAAMWRTEFGWNLYSPRREFTRQLCVDASRPASEVATEAALQEGLIGLHRDLRPWFTLVDLREAERNVGRGEHPADFKYTCSPTYPWLFLQPKLVERELLLKAMAARSRARVPAVSYVCLRTGAILARSSQPLMRSSQLSADSDVCYTLINMGYAPHYARPRRTAAPALVSPPLVISPLAAAQATARGGSPAAAASLKSSPVVAATTAVTRPVRPPSLFDDDSDGDGQPTCAASTSNASSTHKPESMITNGNRRTSVTTPPSTAPKSSRTSIVTSGAADAVYLGALSLAETPHSPAPSTSTNANAAKVLLVADCRPQITAAGNAQLGGGYESGSYYTFCQTNFFEIDNIFGVAKSFEKLRSMLARYQGNTVEKTFLRRLYDSDWLAIVQRVLVCSVTTAQSLQSGVSCLVHCTDGWDRTSQCTALAMLLLDPYYRTIVGFCTLIEKEFCSFGHKFAERSGHQLPGRTTLFAQSGVAGSDTEQQHGGSGSGSAPRLDTSPIFLQFLDAVFQVCRQYPTCFEFTPELLAHLSEVVYSCLYGTFLCNGEQERHLEGVRLRTASVWTDVLRRAQREKQGEVPLCFVNVHYDAATAWRFISQRRRGRGEGGAGGVAPLRDFVLLPNCSSKRLVFWEQLYTREDADHYLSYNPHVHTVKTTQRVSWGPEFDGFLNAEMEEACADRESEMESLVALEGFMEAEANTSATPLPAANTARSSWCVFDAVNCFNCYKPFGMWSTKAQCAACKQHFCTDCHVHDCILQQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQA7</accession>
    <name>A0A088RQA7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_205590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN98050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698757.1">
        <property type="nucleotide sequence ID" value="XM_010700455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQA7"/>
    <dbReference type="GeneID" id="22574771"/>
    <dbReference type="KEGG" id="lpan:LPMP_205590"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200063000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_205590"/>
    <dbReference type="eggNOG" id="ENOG502SEXX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="262305at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="886" mass="94092" checksum="2F38F4F44DD81E12" modified="2014-11-26" version="1">MTLHVNWSNWGASLPPKGYTMSQRNISEAPADYGGQQSSEQASRQHGEGDAVAGRGQLSAAAPLPGSAHRCKRRRTEHVLFISLLKEVFMYLDTIASTQQQQPDHRRVAGHAEEDEEDKIQGTTALPLHAAASRYSTACPAIPHGLWARNRDRSGPLGAASAPLMSVDSAVRDTLRVLQQCWEYCGAPHDAFEPIRLLSPITVHLLLTYGHHTVTHDGQYVVLRGGAEHLPWVGCLYSILLVYAYRHRAAPTIAVATGTDEGDGSVALGSECISRLLLLNCHSFGWLNHNGAGEYECSHRRLYQVREALLELLEDPRFTALGRPAGCHLCASSMVGGDAWTLVLLGDTIVMEGGVPSLGLAHPRDTFTAHYQYGRGIACCVPDRGGDLQLDSTGTPVVAGRVAHTPTAGKGLCAVHRESPQPEAMQASREWHPDPHQQHRHLETPSGGCQVEESFSTLVCSGGHDGPLPGVISSSWLTSTGAAPCRLPAVCCGVCRALGVLGQAVLLGPTGSLVIHLQFDEREWFDMSAPIVPAATAHGWLPTATADTTAACPPLSSHWASQYAADPATALAAVLYAVLQGGSATSFAGQHCHASVGGHRSSPTHVGGSVSLAEFVEWLVWLLNAPQPALVVEWHVSTSTSTTTTTCTTHKCEDVTPSLSRNLGVCGGSQVSVSSPCTPAAQLHSPLVSSRSPVTAPPHSMHSCGATFGSKSSFQVTRAYGRDEGYATASLSTDHPQYEGYLTSSSAPHGTTTSVPLGTLTQPRRPTVMQLLETYSDVVQSRAAVPAPPATTLPTSSVGSSCALPFTHSNGTSEHAAEAMKPHRLLDCLLAAQESLRLCEATSLFDGVERPLVLAKELEVAAEAERLLNASSVVTSLQFRPRSARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQS7</accession>
    <name>A0A088RQS7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Epsilon tubulin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_211210</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698907.1">
        <property type="nucleotide sequence ID" value="XM_010700605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQS7"/>
    <dbReference type="GeneID" id="22574943"/>
    <dbReference type="KEGG" id="lpan:LPMP_211210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210016300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_211210"/>
    <dbReference type="eggNOG" id="KOG1375">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02190">
        <property type="entry name" value="epsilon_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000017">
        <property type="entry name" value="Tubulin epsilon chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004057">
        <property type="entry name" value="Epsilon_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01519">
        <property type="entry name" value="EPSLNTUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="6">
        <location>
            <begin position="39"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="7">
        <location>
            <begin position="265"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN98200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="470" mass="51872" checksum="E399B4393DFACCDD" modified="2014-11-26" version="1">MPREIVTVQVGQCGNQLGQRWFDVMLQEHKAHPHFSEARDAVFLEGMSRPGRLKARCVAVDMEQGVLHAMLRGPLRDIFDDNFFVSDVSGAGNNWAVGHMEYGDRYIDAISEAVRNQVEQCNCIQSFFVMHSLSGGTGSGLGTRVLGMLEDEFPHVFRICPVVMPSEVDDVVTAPYNSCFSLKELIEHADCVLPLDNDALARMSDRALSNGRNGRGVMASGVPQPHSFSAAKPTDTKGLPYDSMNGLVAQLLSNLTCAMRFPGPLNMDINEITTNLVPYPRLHFLTAAIAPLSVSSKHAVVGPRSVDAMIAACLEPAHQFVDARHGQGSSMTREAGKTLAAALIARGPQTTVGDLTRGIGRLREEMVMPYWNEDGFKTALCGVSPLGHRDSMLLLANNCVIRAKVGSMLSKYERLYSVRSHVHHYEQYLSDAYFTHTMETVRMLVDDYAYLDTAAPPKDMPRSMRDLIYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQT0</accession>
    <name>A0A088RQT0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_230250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699184.1">
        <property type="nucleotide sequence ID" value="XM_010700882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQT0"/>
    <dbReference type="GeneID" id="22575229"/>
    <dbReference type="KEGG" id="lpan:LPMP_230250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230007900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_230250"/>
    <dbReference type="eggNOG" id="ENOG502S691">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276446at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="160" mass="17840" checksum="ABD4511C3A00C247" modified="2014-11-26" version="1">MQRNIDKAAGRPLTGLYDGPTITTKDGARPLFASEHARHPNRGQAPRRAPTPPHAPQFAAPSATREDIIAPQSDSYQRDLRSDPTYADDLEHVVAARQRIMTAQSDSYGEAMRGMVAPPPPLDPHAPPAYRQPRVQLDDSWWLLMWSFVVLFIVLAMYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RR22</accession>
    <name>A0A088RR22_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="1">PPIase</shortName>
            <ecNumber evidence="1">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CYP6</name>
        <name evidence="3" type="ORF">LPMP_221330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="1"/>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699135.1">
        <property type="nucleotide sequence ID" value="XM_010700833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RR22"/>
    <dbReference type="GeneID" id="22575179"/>
    <dbReference type="KEGG" id="lpan:LPMP_221330"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220017000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_221330"/>
    <dbReference type="eggNOG" id="KOG0865">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097014">
        <property type="term" value="C:ciliary plasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000049">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF480">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="2">
        <location>
            <begin position="30"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="229" mass="25236" checksum="17A345C75D5F7EC7" modified="2014-11-26" version="1">MWRLSRAALQSNRAALYMPYTPVAANPVVYFDITAEGDALGRVSVELFRDVVPKTSENFRSLCTGERGYGQCLLYYKGIPFHRIIPGFVMQGGDILTKDGRSNVSVFGYPFSDESFEGKAGKHLPGTVGMAHSGPNQNGSQFFFNLGRNEQLDRKFVVVGQVLGGWEIINQVVKLCGSRCGTPVSRAWISDCGQSGGYMAEETQEALRGERAQHAMPGKEVLDLIQPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRC4</accession>
    <name>A0A088RRC4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mitochondrial DNA primase, putative</fullName>
            <ecNumber evidence="4">2.7.7.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">PRI1</name>
        <name evidence="4" type="ORF">LPMP_230840</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic-type primase small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="4"/>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699240.1">
        <property type="nucleotide sequence ID" value="XM_010700938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRC4"/>
    <dbReference type="GeneID" id="22575288"/>
    <dbReference type="KEGG" id="lpan:LPMP_230840"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_110009200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_230840"/>
    <dbReference type="eggNOG" id="ENOG502R9D9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277469at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016817">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002755">
        <property type="entry name" value="DNA_primase_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014819">
        <property type="entry name" value="PriCT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01896">
        <property type="entry name" value="DNA_primase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08707">
        <property type="entry name" value="PriCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Primase C-terminal 2" evidence="3">
        <location>
            <begin position="377"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="478"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="478"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="523"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN98533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="534" mass="60145" checksum="9E9A3C2FF3996429" modified="2014-11-26" version="1">MLNEIRKLPEGSIEEEPHDVAEHYSEETATAHEQYDWRTESHPTESQDTEEAHQNLCNDDTVSENISSSMHEASLREAEAAAALGSDNMDDAIYNNGSSSSRKTPMVKGYRIDEVAALCSSSDAMFARRLPSGGCQFFAWPGTPLSVASSAIVSMPDTIRTVHAVFGRVGTPIDIVMDIDSQVPQEYWSMSKVRLYQRKVLDDVLTPLKEEIEKIGERIETQVVLQSPNLKKASFHIHTRLKDAAFADFYSLHGFLFRFQERLPNVDLQIYRPNGMLRMFSCMKENRTSAIVVFDEPKWHIGFPGGKVSDEQAALHSICVRDPSTFSRVLTFESPRQYNMPAYGGSRVTHGDSNEGTPLPPQVLLPRTEKEAIESASRWLRQATEVEVGEWRTWIGLGLCAFRVAYHFRNAKNLPRPAMAEMLDAWTEASRKCPLKFHNGECEARWAAFNPERLGQNADWWTAYKRLGRLEVPMREAMEREAAHAERRTSRYHPTSATEMSPAPAPSKAAAAPTTGSVTSASRKMKQQKTFRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRL1</accession>
    <name>A0A088RRL1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Palmitoyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_231590</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 8">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family. PFA5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="8"/>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699315.1">
        <property type="nucleotide sequence ID" value="XM_010701013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRL1"/>
    <dbReference type="GeneID" id="22575364"/>
    <dbReference type="KEGG" id="lpan:LPMP_231590"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230023900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_231590"/>
    <dbReference type="eggNOG" id="KOG1311">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF23">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="11">
        <location>
            <begin position="260"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="91"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="397"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN98608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="451" mass="49488" checksum="5A2BC94499AE7A1F" modified="2014-11-26" version="1">MLCCGYCTPAFVALLIIGLALTSDAYCAYMIFRYKNDVWRVIVSLIVLVLTTVIAPLVLWSYYAIIFCSPGFVPHDPWAYPPLYAGPPLHPRAGGEGTTSPSMHSCSLRQQQQPHQATAQMLQTGAPGSLTRWPPSALGISRLPMTSSALVPAISDDTDCANPLLADHPQSSPDSTFAAEANSGAPHARDSIDVITIHVDEVAAPSSHSPCQSLPLHEQRVGPAGYFPALLTQSPEQHQDAGPPVYLNPYSVTTLDRNGGLRFCYTCQQYKPDNAHHCRACRRCVYNFDHHCPFVNNCVGRNNYKLFIIFLLYGGVGATLAGFLMIVIIFAVDQDPFTSKIGWISLPGLDLILGFSLLMFYCQHWVLLHNGQSTLDSLTAGSKSGSQGILCCGEGTRLNSEKKANEARRQKEKVERHIRTLLGKELLWWRRYSPLPVRTDDTADDTVPGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRP5</accession>
    <name>A0A088RRP5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_231200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699277.1">
        <property type="nucleotide sequence ID" value="XM_010700975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRP5"/>
    <dbReference type="GeneID" id="22575325"/>
    <dbReference type="KEGG" id="lpan:LPMP_231200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230019100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_231200"/>
    <dbReference type="eggNOG" id="KOG3379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="672793at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051884">
        <property type="entry name" value="Bis(5'-adenosyl)-TPase_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46243">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46243:SF1">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="3">
        <location>
            <begin position="201"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="289"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN98570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="351" mass="38103" checksum="511E80E68A69BAAC" modified="2014-11-26" version="1">MSRRLTHPGANFNFSSPGDTAEIRSMTADTPASVEKPVVNNNHAYLHIVERTPGDFTPNNLVYHQLQRYHLVPAQSTTAVEAGENAAVLAAFTALVTTLQQQPAQSPEEASAELLTAEETALAAATTAEKLQRDPLASKPDAQAHTAENLRQMHAYAAASVANTTPPILLTEIKDAHRFTFYPFPILAAVSIPYCSQHFCVLVNLKPIVPNHLMVVPIRCVGTIHGLTEEEVDDWGHVMRCTIQVLEHLRRQCYARDSAASSATAAIPSVGNYSIAVQQGSLAGQTVDHLHVHVIPFDPKGKLAGEPEMDEEGQRRRPPRTPAAMQDETNELRLLFAQYTAAAASLSTATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RS65</accession>
    <name>A0A088RS65_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_241760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699515.1">
        <property type="nucleotide sequence ID" value="XM_010701213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RS65"/>
    <dbReference type="GeneID" id="22575585"/>
    <dbReference type="KEGG" id="lpan:LPMP_241760"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240024900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_241760"/>
    <dbReference type="eggNOG" id="KOG4209">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272703at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF92">
        <property type="entry name" value="POLYADENYLATE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="129"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN98808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="245" mass="26625" checksum="EC5BD0BBA70EBFC0" modified="2014-11-26" version="1">MDSDLSAEIARIEAELAQDAEMRQQQQQQQQAPQLQQQPPASLFGFGQTVSVQPQQQQQLFQVLPQQPQQQQSNPFNVNASPFMLTPPQPDYSHQQQQQQSMGCAGQAVAYPSTATPTAHSFSKDTDSRSIFIGNLPRGTDGTPATTPEELVQFFADCGSILNCTVLKDRATGELKGTAYIEFADHTAMGKAIDTKNNASFKGSTIIVCVSTSPRFLLHFSFANVLKPCRGLIRGGSACEQSVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSQ0</accession>
    <name>A0A088RSQ0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein phosphatase, putative</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PP2C</name>
        <name evidence="6" type="ORF">LPMP_250770</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699647.1">
        <property type="nucleotide sequence ID" value="XM_010701345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSQ0"/>
    <dbReference type="GeneID" id="22575725"/>
    <dbReference type="KEGG" id="lpan:LPMP_250770"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250013700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_250770"/>
    <dbReference type="eggNOG" id="KOG0697">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000073">
        <property type="entry name" value="Putative phosphatase 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="5">
        <location>
            <begin position="23"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN98940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="406" mass="45123" checksum="54EA88177B975EE1" modified="2014-11-26" version="1">MGIPLPKPVMTQLQERYGNAIFRCGSNCVNGYRETMEDAHLTYLTDSWGFFGVFDGHVNDQCSQYLEKAWRSAIENEPIPMTDDRMKELALRIDQEWMDSGREGGSTGTFFVALKEGNKVHLQVGNVGDSRVVACIDGACVPLTEDHKPNNEGERQRIENCSGRVENNRVDGSLAVSRAFGDREYKLGGGGQLEQKVIALADVQHRDFTFNSEDFVLLCCDGVFEGNFPNEEVVAYVKQQLETCNDLAEVAGRVCEEAIERGSRDNISCMIVQFRNGVDYAAEPHFTVVPGPFSAPRNSSFRKAYESMADKGNTTVGALLEKRYDTLKAADALTPEETEELSQFEDGPDAKLTGAERQKWFSNYFQKLCEASTNGPGDQMERLQSLQQQAGIPLSILLSLMGEQTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RT80</accession>
    <name>A0A088RT80_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA uridylyltransferase</fullName>
            <ecNumber evidence="4">2.7.7.52</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">3' terminal uridylyl transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">RET2</name>
        <name evidence="17" type="ORF">LPMP_260390</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>RNA(n) + UTP = RNA(n)-3'-uridine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14785"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17348"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173116"/>
            <dbReference type="EC" id="2.7.7.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.52" evidence="4"/>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699860.1">
        <property type="nucleotide sequence ID" value="XM_010701558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RT80"/>
    <dbReference type="SMR" id="A0A088RT80"/>
    <dbReference type="GeneID" id="22575942"/>
    <dbReference type="KEGG" id="lpan:LPMP_260390"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260008700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_260390"/>
    <dbReference type="eggNOG" id="KOG2277">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2274644at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050265">
        <property type="term" value="F:RNA uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000016">
        <property type="entry name" value="Poly(A) polymerase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041060">
        <property type="entry name" value="Ret2_MD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF50">
        <property type="entry name" value="RNA EDITING 3' TERMINAL URIDYLYL TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18528">
        <property type="entry name" value="Ret2_MD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="16">
        <location>
            <begin position="76"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="RNA editing 3' terminal uridylyl transferase 2 middle" evidence="15">
        <location>
            <begin position="188"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="14">
        <location>
            <begin position="388"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00075952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AIN99153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="513" mass="58337" checksum="7C613CF083BC3619" modified="2014-11-26" version="1">MYTPTPLCLYAAVTRRLHYSGVGASSQSGAASSPSTASLSTSEGVSYASHLAASEDHYAQWGRALLEENNRRIGPEQMFRTAIRAQQQLQSLADKWTPDAKIYCCGSLVTHGQMEWGSDLDLACVFDDPYPDHSVQAKRTEKLWSVIKRYMPHYLRSNLMCLTEARTPVVKLRYVNDDKVGRARYTVLTEEEDRKSRTALWDIRNRYLGTKDLEYIATKMGRENVEGIWVERTTYGCRCAVQCTSREQAIEAVGFFPDGVIMTKGMREDYTRDMLDPRFVPEVFMYKWDISFVAYGVKNSYLLRHYLHSGPPAARHAAMAAKAWGKASGVGLGTAAMLTSYAVTVLFVHYLFATRQLAWIDPWSLAHPVHMPRYPDFSPLLDCDPVALGKLLHGFFIYYATHFDYETNIVSLSRPRVSLRSDVNWHFPQNKQGTFSYLLGIEDPYEDVGTGGLNLGRHLHPAKFNQVKQEFARAATTMERYVPSNLPEKTILGVRRASSSNHHHHYHHHNRFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RT88</accession>
    <name>A0A088RT88_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chaperone protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_262500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700069.1">
        <property type="nucleotide sequence ID" value="XM_010701767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RT88"/>
    <dbReference type="GeneID" id="22576153"/>
    <dbReference type="KEGG" id="lpan:LPMP_262500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260029700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_262500"/>
    <dbReference type="eggNOG" id="ENOG502QUPA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="16"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="414"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="474" mass="51812" checksum="076D732674FD73EB" modified="2014-11-26" version="1">MEAVQLAKSVLAADGQPFKILSLAQGFAPVTPETSVLEARRSYMRLAGAIHPDRLQRSFDKATEAFQCLVRAFECFADPKSRKRAAASAQRQAKTEAVVTTAVRGRQANAAPPSSTKSGPSASQPMMKGEKKREKSKSKAAAAPAAKKPRAADLTEEEESETGDDVSEASVADEEAWEACAAANKEPEVSTNRTPIGQLRVGGLYQLTTVGCPKCRSLWEPDARPQYSLFMGRWGKKVHCQLCLFHFGCATALHGCPHCRAPFDYDVSMYDSVQTCHRCRKQFGFPYYPVNQYLIDQVALEEWRERMDQQKASEREARARARRGGGDGSDGASAEEERMQLLVGTCIMEEVCPLCHKRIKSKHRSHVEGCMAKDPKELAASTGRAAKKIASPAPLADKVAKAPVSRAAKRDPKATAAPTKKSAAPTTPRANVPKGKKASVLQKRKRRRGDSSSSEEDEISTESTFSDDDYDDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTE1</accession>
    <name>A0A088RTE1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_261400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699960.1">
        <property type="nucleotide sequence ID" value="XM_010701658.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22576043"/>
    <dbReference type="KEGG" id="lpan:LPMP_261400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260019000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_261400"/>
    <dbReference type="eggNOG" id="KOG0229">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1729">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270720at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215:SF14">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="7">
        <location>
            <begin position="1730"/>
            <end position="1810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="430"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="691"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="881"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="971"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1135"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1300"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1343"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1437"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1773"/>
            <end position="1792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2028"/>
            <end position="2058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2215"/>
            <end position="2240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2279"/>
            <end position="2355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="695"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="984"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1343"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1443"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1474"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="2031"/>
            <end position="2051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2282"/>
            <end position="2296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="2304"/>
            <end position="2317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2320"/>
            <end position="2355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN99253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2413" mass="258728" checksum="DEFAD14CC4A5B1EE" modified="2014-11-26" version="1">MHWTGMADAAAGSDSAGVAPQYYDLSAPLTRPVTTIQIENFTPHKGMIPSLVLADGSHYFGPVMEEGRYRIPCGCGIILFQYDGTVKPNFTVAEAAAPDSGGGGLASFFFGRGAPQDGGASQASAAFSALCKRYQQGDRYGGDWANGTFHGDGVLVTNSFTYHGTWMEGQMQGKGTISYSRKYVDYRPRNTSGSDASTGGSGVGEGVSNLLLKGLSYVSPFELVATAAAPKEYIGDFDTIHYRHGMGLMQYYNGDVYEGEWRDNCRHGRGKLRKMDGEVYDGDWAFDQRHGNGKIMYPNGSYFKGSMEYDQRNGEGIMRFANGDEFFGTFMKDRIDGHGTMRYRNGDVYEGAWRDQLRHGQGKYTLKRTGATMHGEFQSGLIHGQGTVIVPGVSTFVGIFVRGERTIGTMHWHPQPSQQSQGELAHVEAAAAATLESPEAPPPDGTLFPDPGTSSPSATAAIATSIVASKASAKKYLCYQGQWQGEHMHGRGLLWYTNGDFYAGNFHKSHFHGAGNMRYAAEQAEFSGQYVHGIRHGLGLLQYANKSIQAGRWQQNIFVEGYEGEWDGSVFHGIGRLTMPVDIFLAMRSSNSALKLSELSAMLNNGPSIIPTSVPLITGGEEGRSVVSDGATWPAATDAFSSGAAVRRADLPPFFIEFFGLFRNGLRDGLGMLKLPALNSLVGGSWKLAEERKSGGGGGQGDSAGGGGDSDSAAGAPCRRDSTAGRASVPSMIIKGRWVSDVLHCEKGVWAFPNGVVYIGRFRNGARDAARACVWCPDGSVLESGWCGDAPSGDGIWYQRNRTNPVYRTIVPSLLRHSQSQRLSEKNPSTLQSIAPATVGGQSARDAAGADGKGASSALTGDLFSMSYLWGLIGSGLIARGSTGTGDGDGSTDDESDDDRPRRVLVDFGNHLTFFCSWCPYMMDLNTYTAVVLPQIGSQTAPLSDGMPWPQLYHSPSMSAAVCTSQQWAAETAKDGRRAQKNTAAAAPPAAAAGSGSGGSKASIPWPVPTVKQISTCANSLHLAEAPSSVAIGRASGSGVVYFDTGVVLAGEWLGNVPRLATPYRPWSAFDHFIMWQATRASSRNCAGTVPHFTAPRLQSCYTSVLAAAPEHMIGEPRRATGGRLTVTTSPLATNRGGAVETHAPVSPTPPSLQPSPETRCTLCGKNYSFFRKRTHCTLCLRSTCSFCLGHMDTERPTHQEDVKALLRHAYLTAEQAVQLSTAAAAKTALTNVSGSATRPITFPSFSVEQVDHAFDKKNIPTVPICSDCMRAVLWKLRYTQLWIPMSMFASVVEGNKHQREMQRNSGAVAAHQAADNVPSESGTAGGDVDGRAAEATNELTTVAYSQESSPQRSDVGQSLSLSPDRPAASAAALDERERHQQGGMLLDGSDALRCAATADPSEEVSADVSAHAATLEMDSAAIGEAAHDPLAITQAEEAATQSTPSTPSTGSPSRVNDGAVTDTSPAPAPPPASASSRSLRPSSHAETRWRTCSTVLPPTQYIIYSGYTSHTIPHVYGELWWGRQHYYRGGFCAGERHGFGTQYMPNGEWYEGGFERDAWHGEGVYYLDDGSALLGEFRKGKLHVVHYRGEVEESDVGGVRPHGRGIGYSPDGSTYNGEWVHGQRHGTGMLHLADGSSVYSGTFVSDAMEGMGKLVTISGAYYGEFTENRQNGKGLLFTANCVVEGSWVQGTSSGFTRIYERATGEVYETTYHDGNERDDCFTAPVMIEDDDAVECGQCGMAFSFFHRRHHCRLCGDVFCDSCTQHRATLPSTVTGNGGPNAKRDSGSPSASVVNGQQLRVCDACFFRLSQRRMIALRRYADGSVYAGCWSQGQWVSRGLYCRPDGVFVVMDTHGHALLPLVHIPKAKDQLQGDASGAIQESAKPSAVPPARGLGVGRRPLRTTGLPVSSSILQDAAPAKELLDGVAESSSRKDLDAFLLWWATTRSRCALQVPLDISLVTHYQRMPAQMLRGQEATVRAGSDVAMYLAAPARCILEAPRTPSLTPIRLFVTLADSRREMREMVEGELERTSASAASPTTAAAAASESTLSTEEKRTMDSDVEAAALRASRFMPVAIPRAPAVPITPATMPVTSASELPTGTPTVYPGSFHPEHHVPGADPPQVCNVDAWVTRPPPSIDPDDISDEDLAKMIQAEKLSWPTDASDDKHAAASTIQSLMPPTPAPPPPGFNTTVSWDVWTTRDVPRYTPPLRTAVAAGARPAGHSPVEKAAGSGEATAAPPPILRSEADMYFACPFWGPTVPDAQLLLEQGKMAQVTKLMRRLQQQHSQTLNPQQQQHQEKQRSDSGSSDCDSAGSDCRGATTSGRGKTQRSSVADASLSTLQSPQGGSTNASASSWEAGHLFSPEQRAQCGDGWAPTPMRGPFVFDISTHEKRRSADGLRWYAKVTQREVTNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTF7</accession>
    <name>A0A088RTF7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_260410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699862.1">
        <property type="nucleotide sequence ID" value="XM_010701560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTF7"/>
    <dbReference type="GeneID" id="22575944"/>
    <dbReference type="KEGG" id="lpan:LPMP_260410"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260008900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_260410"/>
    <dbReference type="eggNOG" id="ENOG502SAND">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="257001at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="98" mass="11287" checksum="EF83DC569FA86574" modified="2014-11-26" version="1">MADNLSKHQVMRDYYKESQQAASVPMKCPYCKRQGRFAANTYEIAKRIPSVMTEGMALCHFCKAPIGRQADMVLQLRSWYCGYCELCVCPGCQKKHKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTI1</accession>
    <name>A0A088RTI1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_231140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699271.1">
        <property type="nucleotide sequence ID" value="XM_010700969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTI1"/>
    <dbReference type="GeneID" id="22575319"/>
    <dbReference type="KEGG" id="lpan:LPMP_231140"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230018400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_231140"/>
    <dbReference type="eggNOG" id="ENOG502S6A8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273669at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="847"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="898"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1019"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="847"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="858"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="957"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="968"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="986"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1019"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1042"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1078"/>
            <end position="1092"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1100" mass="114430" checksum="9CCAE87D923BDA75" modified="2014-11-26" version="1">MVGSMIAPPTTFAEAGVPLHTRLLRAVESDGQAIAPTPLLIRVLRRTASDFADVIVDGRCATGTHQVGSAAAVWVHNEKVRANASSAAGLSSTLPQQRTKGSSPSSRGTTDADGSCAMPLYRTEAALSECRSLLVLYTLHCLLSATQEPNLDAGGGSNAHVRADADGRVQEVPLAARNWAPEVSIIVAETETSAVELHRMCTSLGEACGLRLNTVLQNGNEPPASLVLSPAISTEKNAANPEVSAAPAVESEADNDEDSGGRSSSAKKTTSAGEWPYLASIIVTTAHGFLSWNLSALLNAGVDVAVAGSGAAMADVDSAKDAVNTGATAAAAASSSPHMRRVHPHIVSIVVEEMGGASVTSPMGADKAVQQWREVYHTLYAAVLRQNSRYASTAHLHAHYMWVCRGPVSRLPATLRQCFSRRSRRYYQIQPSTYISPLTVSLMPHPHEGLSSPAESLGIRLVLSQSQLDKEAQLRRIVTDRSGLFHRVLLLTHNKEVSQLSALITSWGVSKEAPTASTVSASSSNSVVFTRRMDSLGAQQQCHTAYLQSCEAAEQVLPTAASSSPPPYSSPVVVTLVAWDALTSLDIMDVDVIIQYYPPQKSLTDQEWAEFIQVLHTTVDGEREIELSLRQNRNNKEETIQEKLQQLREYTTTRAAERSEPPQRPLPVLVTLMLAADFTLSAYFLHQYMYSGATGTLTRAATATSLASTGPAPGRPGVQEPVEYPVPVLDISPKHPYFIPLVCGHTGDVEWPATAPGSPPRPRAVTAGVSGTEAGLVSTLTSGEVITVKRVLVAKLQKEQRRLNSFANLSGTGSETNSMGFSGNISVAATPSSAQLLAQGSVTVAGTATSGGSARLNSTGSSGTTAGSRRVSSAERNSFTKLVRNAGVAAINYAASPTTGASDVRANSRAGNSASTGAVGGGGGNKNNNQRQHQQGGGGGGKELPLSAPSSGGGRNSSGNRNARFSALQNSSTGDRSGNNGKDGINSRSNGGLSSSNGGGGASSNTFAAAAGVAKTLGSAAAPGSAGRSDSGSKEDGKGNTMARSLSTSKSAALDSTAAYSGAKGVDSSSGGYGKVSANKRRSRNTRAKKKQQQQLSSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RU06</accession>
    <name>A0A088RU06_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_270200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700107.1">
        <property type="nucleotide sequence ID" value="XM_010701805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RU06"/>
    <dbReference type="GeneID" id="22576196"/>
    <dbReference type="KEGG" id="lpan:LPMP_270200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270007500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_270200"/>
    <dbReference type="eggNOG" id="ENOG502QWTD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270226at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:002119">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="4">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="278"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN99400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="365" mass="40262" checksum="BD7645D9FC979A1B" modified="2014-11-26" version="1">MESRSRVLGAVRTLSEAVSTHAKNEEARRLVIRVVSSSYESFSLPQLEHALCYFTNHNSNYTNVGNDEFHVLVEETLNNSIRSILVYDDFSGFFGDAEVYSLSMAFQYNLSVEALTLRGINISDEAICSLCEALVRSRVNYIDLSNTPLEDEAGRSIAALAHVNPYLRTVIVDDTLIADDVLDEIDVACQFNQSNFEGNKGEVDESLLRPADLGRLKHRLQQIIRAQERKTHYCVAHLFGCCPNGEMCLYAHSLGKSGMDEIDASLSAKISELFANGGNWEERLPPRPTDGPSWRNPEDEVKRAPRSNKARRRGEQVNSTPATAPVQRTRWSPVLSGAAGMCCGLILVGLAGVVARRLSPGSARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RU93</accession>
    <name>A0A088RU93_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquitin activating enzyme, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_280360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700379.1">
        <property type="nucleotide sequence ID" value="XM_010702077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RU93"/>
    <dbReference type="GeneID" id="22576481"/>
    <dbReference type="KEGG" id="lpan:LPMP_280360"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280009000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_280360"/>
    <dbReference type="eggNOG" id="KOG2014">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="412647at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF162">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="1">
        <location>
            <begin position="9"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="287" mass="30512" checksum="CA36D0B258EA28B3" modified="2014-11-26" version="1">MIDAEAVRYDRQIRLWGKATQQQIMHTSVALHGIAGAAAEVTKNLVLAGVRAVAVADEGHVTDVDVCTNYLMQGEGGGTRGARALSALQRLNPYVTVYDAVTKLDGSSGPRVTMATVASVEDALPHAHVAVPGADIVAFHVTCGPTVLALFLYRRLPARSLAEQWRCLVAEPSLLAEKPRGYQRVVLALHVRTDAVSLGFAAAAAKAYEVVERLHLQQLTAADVQEVLQSCAHDAGSGDCVSDTIAGACVAQHLIRQISALDQPPDAQSYHWMLCECGAEVECLVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVN8</accession>
    <name>A0A088RVN8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_262210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700041.1">
        <property type="nucleotide sequence ID" value="XM_010701739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVN8"/>
    <dbReference type="GeneID" id="22576124"/>
    <dbReference type="KEGG" id="lpan:LPMP_262210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260026900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_262210"/>
    <dbReference type="eggNOG" id="ENOG502QQ80">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="247693at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="811" mass="87974" checksum="0BBBCA718409B1F9" modified="2014-11-26" version="1">MADYTFDSAIRRADGVGTTATLDDSSLLRSLIKSAKSAHSTLGRALDNNLSHQRFGGAEMEPSALTMNWRERKRQMRLQHEMQVVCDDIHLRATGTRRDQRDGVPGASVRGTAPRPLAAFTFSATGMVMGCTADKSQLFIPALPTMAPSMTAAADDGTEVLGGTRIGGDGRGYVTLIGAVPTYNTTRLIEDNYELISSFRAYRTDALRAEQQTALRDVSAPHPDLLLQLAPLVQPVQSDEAAQQHLLVDQETLPYHLCQRYRQARASHSMSAAHVNEAAVAVDGGEEAAPHSPKSPPQVDGTAAVATAAKGTWPFTCQGRPAITGAQHSGTVGSAGGKGGNELHRRRLIGHRQPCLGQYHVRYTVVEPRVVGGYVAPQAPVRNTQQHDEANPRQDAEDSGSIFGQTQREDCRLTVNLHGSYSTGADATPHRGGSTHGQNIKGSSMFVSESPRQIGHGTAAPDVFYWPYPDVRSTTKRVPCLVQLDNPTTQRRREPLVSGVPGSVYEVCGDIAANQTRTVAMDRTTGRSSHWYGRAPPNARGEPLDVDEALRATRPKERAVTLLPRTHARDPSADSARTLAVVDTSVSVERNLAYPQPFIGGLTQLAHIRDFGKVLGRAKREERAMRNMGGGAGNDVLPGETEECEWTQRRSRAIVIHPRAPGHQPLHAPNATELGDVPSLALTKPRSGCTTDLGKGQARPMHLLPMHDLTYSAEPGYVLTGPRAKGTPSIGRTVSRQQARSRTAEEGCGALVMYNPTDYLTPRVKSVPDFEKQITKAHEFRGHRVQSERYLQLFPSAPGPGHYTVNYSQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVU5</accession>
    <name>A0A088RVU5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RanBP2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_300230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701058.1">
        <property type="nucleotide sequence ID" value="XM_010702756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVU5"/>
    <dbReference type="GeneID" id="22577077"/>
    <dbReference type="KEGG" id="lpan:LPMP_300230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300007600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_300230"/>
    <dbReference type="eggNOG" id="ENOG502S20U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="262731at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="203"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="233"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO00258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="432" mass="46942" checksum="B5D5E9FD3656B83E" modified="2014-11-26" version="1">MNYLRTIVSDVKLKYRASRVVDECVLGREKPEFPKFLTECVTIADGHPELILSTIRLYLIYSQPESAYGGLLLLEQLVSLCNYAFHLALARDCDIQDLIIHLAVRRGEGEAHRKAQRLARLTLLEYSRVFVDDRDLMRLSGLVSSFEHRTHRSLMRCLNVQNRRVRFREVGVNDIVLISPEECLGYPSSSAGRPVKPLQLSSAPEVWPCHVCTYLNAPSATCCAACETLRTTDTSEHHSSPDMPSKTSPAFSTPVPTATATSPGSRSPVVPPLPMAERGAMERGDSQASSHASVEDMDETFPINNLVSTSEVQLYPSHGPPTVVCVGPVHLSHSATSTAVPAYMSDASEPISPSTDSELRDGADEGDCNSIGGSTAHAVASHAQEKGGCRSEFEYEINKEPSDATRQTVCATEATLCSTAAALPLITRPNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWG9</accession>
    <name>A0A088RWG9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ubiquitin hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_300260</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701061.1">
        <property type="nucleotide sequence ID" value="XM_010702759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWG9"/>
    <dbReference type="GeneID" id="22577080"/>
    <dbReference type="KEGG" id="lpan:LPMP_300260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300007900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_300260"/>
    <dbReference type="eggNOG" id="KOG1275">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8191639at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06143">
        <property type="entry name" value="PAN2_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000028">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex catalytic subunit PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050785">
        <property type="entry name" value="PAN2-PAN3_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028881">
        <property type="entry name" value="PAN2_UCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728">
        <property type="entry name" value="DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728:SF0">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13423">
        <property type="entry name" value="UCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="7">
        <location>
            <begin position="844"/>
            <end position="1027"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO00261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1128" mass="125461" checksum="735F582DA5AFA4E3" modified="2014-11-26" version="1">MSLSSQGSAPWKFRGDATASIGAITAVEFDPDVELLWVCDAFGTLMSFSLQSQGQGEAPAWVNYSSFSVSSRPATSIFFLNIGGERMVTVADREVIRGYKRGGVLMMCLPQPTAVQSYIDLFQANNSTGTMFYTGNAGLTRLILNNQETDQLTVSVEATVVALKQCDQWVATGSASGAVCVRSASDLSVVGHVSPSRNRVMALEVFDNTVMVAYSEWSATSFVKVFDVRKMSEAVSTIQDIPSGNVTQMRRYQDGFGLSSDRAFLLSPGGFHIIQLDQEKPVFSSSPLSEGSCTAVAVSPSNMCAAIGNDKGTFYALAHPATRDDYVMSTFIQPVRPKHPVYHHSWEEPSIADGFDDSADLGTLASNWPEEDYMILTVPQKLRCVNYESHSIVPNEWGLMRADSCLPDPKDKLSSILPNPYPFNTQLGDDPACAQEALLELRKDLKRKHKSSRGGGGEYSPMEDSLQVCYSVQHKLDWRSYNEIAQRVIGIDNSFPECWITPLLQSLYLCQPPEFPIRKVILRHLCKREFCMTCEIAFIFANMLSTSASVLGMKGEALPPIVPVAHFIRAVRQIRAFTNAGVFQRPKSRDDAVAKMHMAQRLVLETLHKDLQDQKAYPFMNYEAPPEYEAAIAALFGTEFTSNGRVHIEPRFYWEVPGSALKVDEGLQHLLKQLEGYKDQVQIKRLPPIIVLLLNPEHSNLKPPTSLKISRAGKEDYNYVLNSNIVHLADDIEDTGNFVSQQRIKDDSFSLVNDYRVTAPMKMQELERLVPALRSYSAVVTFYALDNLTTPPYARLDDSRTPNLWHLLGPLLTNDVLSRPLLRDPAKQAFRSPLASYTEIRAGDLIAIDAEYVVLKWASRDEGSEMFYVSQRKPHMGLARVSCILSSKDGDERTIVDDYVHIPEEIEDYVTQYSGIHPGDLDPLESSKSLTSLKSTYLKLRALVDGGVVFVGHGLAQDFRVCNIVVPRKQIIDTLEIFHKPGSRYLSLRFLAYHVLGESVQEDEHDSIEDARTSLRLYRKYQQLKIEGTFESVLDHLMAKGAETSWYVPDTKSLFRDIPQTPPVSVMGSPVLEMGKTVTADDDKDVDTFAMAAVVAAATDGDDDDEDGDNDTPIASEVLEAVRKSMES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWH3</accession>
    <name>A0A088RWH3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_300310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701066.1">
        <property type="nucleotide sequence ID" value="XM_010702764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWH3"/>
    <dbReference type="GeneID" id="22577085"/>
    <dbReference type="KEGG" id="lpan:LPMP_300310"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300008400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_300310"/>
    <dbReference type="eggNOG" id="ENOG502SH2W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="258639at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO00266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="150" mass="16571" checksum="92872C541C36C731" modified="2014-11-26" version="1">MALSGLLCRASCCAAPLLRGGRFYRGGLSRASSTALALTLPISASSTSSSVVPLIRVDSLRDSKRGYAQHRNTHDSNTEDISNTYFDVQDVDADRLTHFYWDSNDDADTPYGDFTLDNFFGEGEGDEWAGESLAFVDERDQPLLDEEYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWT5</accession>
    <name>A0A088RWT5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Endoplasmic reticulum vesicle transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_310280</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERGIC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701418.1">
        <property type="nucleotide sequence ID" value="XM_010703116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWT5"/>
    <dbReference type="GeneID" id="22577454"/>
    <dbReference type="KEGG" id="lpan:LPMP_310280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310007800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_310280"/>
    <dbReference type="eggNOG" id="KOG2667">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270930at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF25">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="8">
        <location>
            <begin position="6"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="7">
        <location>
            <begin position="138"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIO00618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="340" mass="38300" checksum="1D50E1802C3AF126" modified="2014-11-26" version="1">MRLLLKCDLFRVVQDSENHLTPATPYGAAISIATTVVLMVLLISEAYGYFSGHKNCHITPSAFKNTLDADMQRRLDRLHFSIALPYMPCHRIATETVSGLEHNEETERDTDVWLYHIPYGSFASNSSAAYISGEALSEVERGCLVTGTAPIAARPASFNIILKDNTMADFRKHRPDFQIHYFSAGNAYKDWGVSQIRRQTLEPMSNFKSATDPLHRQFHQFFLQLIPTTVDLPGKDDRFGYQYTAFYSLVRYNGRGRAPGLYFSYRLSPFSMDCIVQYDTISHFLVNLCAVVGGVYTVAGMVGAGLEWLVRERRLKEVSSRNRRNAETLKNAAGEAPITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RX94</accession>
    <name>A0A088RX94_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">T-complex protein 11-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_303390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCP11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701361.1">
        <property type="nucleotide sequence ID" value="XM_010703059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RX94"/>
    <dbReference type="GeneID" id="22577392"/>
    <dbReference type="KEGG" id="lpan:LPMP_303390"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300038800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_303390"/>
    <dbReference type="eggNOG" id="KOG1981">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276323at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008862">
        <property type="entry name" value="Tcp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832:SF11">
        <property type="entry name" value="LD23868P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832">
        <property type="entry name" value="TESTIS-SPECIFIC PROTEIN PBS13 T-COMPLEX 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05794">
        <property type="entry name" value="Tcp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="346"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="387"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="873" mass="97267" checksum="3F9DD909FDF50958" modified="2014-11-26" version="1">MSSAADGASDGGDTASTKGAPAPKQRVRIADSMRELSADIQQLEDLGLSLDPLTPPSSDSVEHILITDSWSCSVCGATSAAICPFTGKPHRRRLVTIAQHALGLIERHVGKVYVRPAPLSQRVEGEVQVRTQRRSTMNPHTFLLAFYFASQAPATPEAAGAEARTPPCSRKPGAFSSRGGSEWTRECARHLLDVVREIKVYGASPTDDVYCHSLLKSMRSAWRQYSRQVKWELAEGSASESESPTARLSGESTQASPPKAVKARDELVNCTRQTLMEAMAHSRKDSDNQDLKRFTALLYHRLSRLCTADEFADVKRRVEQIEATDSTPRIEYTTPPCVMLDTNTTASEDEGGGAAASLVRSSTPGGAATPGYERRHAGPELPPGWYVDERGISRPPADHEERKRRERYLQKEFKAQKAYEAVMQMETDKGKPEQLQAEVVAALTQAELQLLSTDLNTTPPRLQRLFRLLTFVEDRFVEALPSRLRPRLRQEFHDVLDWNVIQRQACGNARYISNLVRFVGEKVIECSSPAREATMAARMTTVCGDIEHCTPDVGTAVANAFAFLVEAIRELREDVAKFSLVMINTSLKQNAVQYIQEFITECLPLPRKWAGSIAFLRRFINDERVLLWSSTSVPQAWISITPGERRVRGALLVGTLSLLRSGQHTSLDRWVDLPPEIFYFEKSIIFKAANTVQECTLLLLLDGAISSVLARRGIKAATVPGVIRHLHSQIMSLLAEDIRLNALKDSVIDFVESQLYHLHFGEAAHDCEDSLVALAQKVTLTDTERQTMRSTIDKMTNTEDPLYVTFERRVLQFMETVLLKNSSDVAPLGLVTDTLKQQVQLLQHMLVFHWEVYMPSYRELLPLLSLESVAAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXJ7</accession>
    <name>A0A088RXJ7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LPMP_313060</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701688.1">
        <property type="nucleotide sequence ID" value="XM_010703386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXJ7"/>
    <dbReference type="GeneID" id="22577732"/>
    <dbReference type="KEGG" id="lpan:LPMP_313060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310039000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_313060"/>
    <dbReference type="eggNOG" id="KOG0589">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08215">
        <property type="entry name" value="STKc_Nek"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000097">
        <property type="entry name" value="Probable serine/threonine-protein kinase nek1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000535">
        <property type="entry name" value="Serine/threonine-protein kinase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="19"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="12">
        <location>
            <begin position="329"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIO00888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="429" mass="48506" checksum="F90BB95F01E2BF2A" modified="2014-11-26" version="1">MSAFSSVLGAPGATGDLKYVKKKLIGTGSYGEAWLVERLSDKAIFVAKTMDLGKMSSRDRTYAYSEIKCLASCHHPNIIKYIEDKEDNEHLLIVMEFADSGDLDRQIKARSTDFKHFQEHEALFLFLQLCLALDHIHAHKMLHRDIKGANVLLTSTGLIKIGDFGFSHQYDDTVSGVVANTFCGTPYYLAPELWNNQRYSKKADVWSLGVLLYEIMALKRPFTSTNMKGLMAKVLSGDYESLPEVYSADFRDVVRKILVCDAAQRPSVRDIFRFPYVREGLKVFMHTMRKNSRIDNEVKEALMEHVTVILSSESVEEPKTATVGQINKDVFFSGYLNKLKGGDNHSWKRRYLQVQKGHFIMSEKESDTEGKALSLEHIQSVCPVPVSTAKRMHVFALHTTSGKSMWFEAASLESMEEWIHAIQRGLGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RY17</accession>
    <name>A0A088RY17_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_292080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700812.1">
        <property type="nucleotide sequence ID" value="XM_010702510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RY17"/>
    <dbReference type="GeneID" id="22576971"/>
    <dbReference type="KEGG" id="lpan:LPMP_292080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290023000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_292080"/>
    <dbReference type="eggNOG" id="KOG1991">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="760868at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF52">
        <property type="entry name" value="IMPORTIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO00155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1093" mass="121377" checksum="87A8B603B9157883" modified="2014-11-26" version="1">MTSVDVLQLLQLAYHGSKDERTQATSELEAAMQSPETGPNCLLALLRAGLEPSLPKEQSLSALLFAKNAMLHLIGDDIVTHTPGFLAEMESLLFAGMFRVPDGHRRILRACIMNVTSGFEWNYLGELMPLIDRDLSAVSVDEALGSLEFLYTYTKRFKTPGLVPTPLKLEVCTVLVRKLPDYVGYNDMRVCRFVFKLTECILETGLQLTSSKEMSGDALDGLFQLMLAFPQQHYNAALAAGGTMYAEYVKCLKRIAMASYSIVNDATRRKKPAPVAKHFLQAHSSAFLSTWLQWLQLCVSSTDRHTHHKSEMFALRYVKLCTLDETLYTQHLRPHAMELIEHVLFPYLCFHEEDEEVFADQDDLADYVKYMMEEGFGNAELSTRQAASNTILALFGNKKKFHDPAPLLQALLGVLATGFESADVTTATGSARLFGYLHLLSILRKFLKEVPAIWQGQMTQVLVRYVAPCLQPSIPSVGVRCKAIVVCQRYSKVVMPSETDFASFMQMMCGLIQDTDMRVRLTGIDAMCTLLEMKRARPYLTPILVPLVEECLVFLSKVQTTFVPLVILHLATHFAPELTPVMSKLAHTLVQHFLATMHDMEQQEIDGGVALGDDAVDVSMYEQAAFSADALLDAVLTVVTSCGENEATFVSVRVDALRLVRHVLQQPDNFDMIEKTLSVLLHVLYFSKPIPPECWELLPLVYALVDSGVGVDFFNSIEEVLDNFVSGAPVEFLGDTALMSATYKTCEKMLVGGVVCVAECQMAPAQLIEAMLHTAKANTEHPRLFDPYLPQFVGLLLQSLLHPDIQGGDVRVRIWVIAALMDFFYYDAAATFEVIVQVNAYPSFFDGLLFFFRGCINDGTAAAAAAGAGKAGRRKQKVKKEDAAEVVENLSLLTRKVAILGLSSLLVYATDPHLATSPPPQRSDFASRYLDPLTRVVQYCIFTNEETYAPRCTLSEANLEKIKLGVEDDIEDYEVNDEAVLGVDGGDDTVGSYEDASDDTDADLPVAQSDLELDEGDDYESPIDDINEVDFFLNWVHMLPQLSPAAQAAAHAVLRPESDYLRASHTAGRYRHLCKELEAALKKDFQMRAELTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RY23</accession>
    <name>A0A088RY23_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_320210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO00909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701709.1">
        <property type="nucleotide sequence ID" value="XM_010703407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RY23"/>
    <dbReference type="GeneID" id="22577762"/>
    <dbReference type="KEGG" id="lpan:LPMP_320210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320006900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_320210"/>
    <dbReference type="eggNOG" id="ENOG502S5X5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269392at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="125" mass="13750" checksum="56D51735C38B5DFE" modified="2014-11-26" version="1">MSASEVAGSTPTSKPRRSVANYTEPPKKNSYLVKLSRFYSTKIPMGIREFVIAGPLLLAALGIAYFTPSLIPAEQFTQGLTPHTQDMHEYTLEPIYDAHGGLRGYRRINTKRTSEECVGAKSAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYC5</accession>
    <name>A0A088RYC5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="12">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_321230</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="12"/>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701809.1">
        <property type="nucleotide sequence ID" value="XM_010703507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYC5"/>
    <dbReference type="GeneID" id="22577864"/>
    <dbReference type="KEGG" id="lpan:LPMP_321230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320017600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_321230"/>
    <dbReference type="eggNOG" id="KOG3071">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10259681at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF126">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIO01009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="328" mass="37452" checksum="2EC2FB6A6B38CC44" modified="2014-11-26" version="1">MISIERAEKIAAAIELPDWVLRMSASLMYSCFGPFVDAFERSVKMYCSAQYAFVESWMHAHAHPFAKRLPYLNPWHGVASILAYLCLILAFRVLCPFLSKLSCRSLGLVHNLGLHLLSLYMCLGLLISARAAGYSLWNNAAGTSPAEWRIAKLIWLFYVSKVVEWLDTVIMLLKQNHHQVTFLHVYHHSTIFVLWWLATLAAPAGESYYSAMVNSGVHVVMYGYYFLTLLFPTGNVRNVLNRFKFVITKGQMWQFFFNCLQSAYDLVWVPRENLKYSPALLQLLLCYMISLLALFGNFLVKSKKKPLRHHHVDAATASAAKRDRAAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYF9</accession>
    <name>A0A088RYF9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_321530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701839.1">
        <property type="nucleotide sequence ID" value="XM_010703537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYF9"/>
    <dbReference type="GeneID" id="22577894"/>
    <dbReference type="KEGG" id="lpan:LPMP_321530"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320020900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_321530"/>
    <dbReference type="eggNOG" id="ENOG502S0BV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275848at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO01039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="161" mass="18645" checksum="F1AF297E0C51D45B" modified="2014-11-26" version="1">MKWLSRLMRRTKRTPLPPKPYVDTASAGKHMVDARLYDSSDLTQVDPEKPHWQEMRFESREKVPFFDLFGCNRDWSWSLFKLSSLFFVMVFYWEMRSLAYMKDDPMRISSTTTVSPVPDYARDEKATEEELRKAGFAYIGVAQLDNLGIPAAASPEPGHKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYV7</accession>
    <name>A0A088RYV7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_330400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702133.1">
        <property type="nucleotide sequence ID" value="XM_010703831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYV7"/>
    <dbReference type="GeneID" id="22578193"/>
    <dbReference type="KEGG" id="lpan:LPMP_330400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330008500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_330400"/>
    <dbReference type="eggNOG" id="ENOG502QUQS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272502at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40430">
        <property type="entry name" value="T. BRUCEI SPP.-SPECIFIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40430:SF1">
        <property type="entry name" value="T. BRUCEI SPP.-SPECIFIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="370" mass="41169" checksum="7AC877FBCFEDE64F" modified="2014-11-26" version="1">MSDLRAMPGYAEMKDYYNGDYVPYDLLTRYDALQLELRKRREQHFVTLSQASDVAMSHDGLAATSTLPQLAVNSPYGTRRANEHQQQVLPWSLRSPHRATRHRSGSWGKGDSGGQRANRRGSIHRCILRPSMELEDIYAARQSSPSCIFGASSPTQNSFPLGSSARHIAPSSASTSHDGADAVAQPPTALSSSALRRHRQLPKHRSKPLAKAYSGEPSPGDPYEAAAEARRQEQFLSESKRLGKPFVPSGSSGLDVPTRFMLGDCVRMLYRSIAPEWRVATPVVVSTAEDLVAVYFSLDKLSKEQVTALLQYMNASLKYNTAVREFHLSKVDEGWDVLTNDGYVLYTFRPPWVKKRVFLPDTITPPHAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZ34</accession>
    <name>A0A088RZ34_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleoside triphosphate hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_331260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702218.1">
        <property type="nucleotide sequence ID" value="XM_010703916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZ34"/>
    <dbReference type="GeneID" id="22578279"/>
    <dbReference type="KEGG" id="lpan:LPMP_331260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330017700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_331260"/>
    <dbReference type="eggNOG" id="KOG0743">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="315"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="414"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="586"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="438"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="586"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO01418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="638" mass="70759" checksum="DCB5B58DD7CD9E5F" modified="2014-11-26" version="1">MDSYVDLLNLNFMYSLRTGNLLTDMMIAALLPLVSSAIAYLTRTWWPQLVSRVLSYFANVDSTSATFKTLEHSGGLYYGHTLRVALSTYVTKVLKPRFDVAELKYISIPGKLLRDAGSYTEALRDYCFVDAGPAKELPMRLTTHLELKQSVAGDDNDKSGRSKGEGRQGEPGNSVAAQESLFTITQYKHSFPTFMRGLCLTRANTTEASEASEAVAQLERDANANGDAIQSLLERSLEHYRFQYKEATKRTERYLYQPLLTRQKLGFGALVCNCYPLRSEKTFQSLFFPAKPRLIKLIDDFEKKTGKYAIPGYPQKLVLLLYGPPGTGKTSLAKAVAAYTKRDLFAISLSRIRNDEELIKCMFSGRFKVKEKQNDSNFDNCRGCRGSNDSMEVLDPAKLVYILEDVDATTAIVLKDESEEGEAGGEERKQQKRRRAEVSTTPPLSSDTKSSDRVTGENSDAADVVSSGKASTSSEKALTKHEMVKVTAKNQRAASALTIEGLTKALNGVLDFPQRIVIMTTNHIEKLHPSLLRPGVVTMKLHMHNFDAACAVAMVEHYFSHTTLLPAQLEELRSLLEAASVNTSKLDSTMSTSDDSANSSTPNTKDLSPAELELRCAECDTIEELLEVLRQGSRVNIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZI6</accession>
    <name>A0A088RZI6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_310870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701475.1">
        <property type="nucleotide sequence ID" value="XM_010703173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZI6"/>
    <dbReference type="GeneID" id="22577513"/>
    <dbReference type="KEGG" id="lpan:LPMP_310870"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310015400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_310870"/>
    <dbReference type="eggNOG" id="ENOG502SAW8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="263936at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839144" evidence="2">
        <location>
            <begin position="21"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="79" mass="8304" checksum="FF4833D3C8A06D70" modified="2014-11-26" version="1">MSAMQLLIVALAACVSLAAAKSKEEFPLVWVCLGITVVGVIVALFVAYKRPDELHLPGSVVMTAVESAPGNGKNSEEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZS7</accession>
    <name>A0A088RZS7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_332230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702314.1">
        <property type="nucleotide sequence ID" value="XM_010704012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZS7"/>
    <dbReference type="GeneID" id="22578376"/>
    <dbReference type="KEGG" id="lpan:LPMP_332230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330029800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_332230"/>
    <dbReference type="eggNOG" id="ENOG502SAWW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18412at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23024">
        <property type="entry name" value="zf-HIT_ZNHIT2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="3">
        <location>
            <begin position="3"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO01514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="215" mass="23512" checksum="97A94BEE1124E929" modified="2014-11-26" version="1">MKCIVCEADKASYRCRTCRSAYCSSKCYKKHRMPRAEAAAEVAQGNATTSSLAYLCETVVAAQLPEMERPEKRRRAEAEADVFLNTPHERAAAAHRSEHDAPSSTPPSVEDSAKTATEVLEENETVGAGPQPPAPEEYAGDAGAVYTLQEKHLCALEGHPRVRSALCSPSLQKLIKTIDSSRSRLDALEAAQYNNADFKEFCIEVIRVIAEVEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZW2</accession>
    <name>A0A088RZW2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_340150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702443.1">
        <property type="nucleotide sequence ID" value="XM_010704141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZW2"/>
    <dbReference type="GeneID" id="22578519"/>
    <dbReference type="KEGG" id="lpan:LPMP_340150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340006700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_340150"/>
    <dbReference type="eggNOG" id="ENOG502SKQ9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="262497at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO01643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="339" mass="38969" checksum="E34F04AC3BA6ADBC" modified="2014-11-26" version="1">MTGLDYAAKHGELERLVKRYCEHKKQQARSLHQQLREEVSTNVELRKYIAFLEGKLQAESKNAKQLGRLLDVRKNDIEDTLIDHKRHLDALTAGMESRLRMSERCERVCAELATSLEGRENQHCADVNAFHTSKALLEAGLAASNKTVPTELQYSHDVEDSVTKLRNGVPVRNKFVLVQECDMNLKTSYTKHDTFLERDECAARTNLLDAERDERQSLLSSFFRASATYLNHLLAEQQERDTRLYRAEDLLRLQQMDLTNRMNKEMDLQQDRCVHAEMQQRVLALQCKSVLRIVGDALESLPGLDVEAVMLELESRVQGVLQLPNSHVSNECRTHKSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S020</accession>
    <name>A0A088S020_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein transport protein Sec13, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_320060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO00895.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701695.1">
        <property type="nucleotide sequence ID" value="XM_010703393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S020"/>
    <dbReference type="GeneID" id="22577747"/>
    <dbReference type="KEGG" id="lpan:LPMP_320060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320005500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_320060"/>
    <dbReference type="eggNOG" id="KOG1332">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="364224at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090114">
        <property type="term" value="P:COPII-coated vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001024">
        <property type="entry name" value="Protein transport protein Sec13, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF5">
        <property type="entry name" value="TRANSPORT PROTEIN SEC13, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO00895.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="347" mass="38214" checksum="FD9F3D0CFC176026" modified="2026-01-28" version="2">MHFQAFPQPPRAPGMPPHLANGVASPDALQLPVAQVHTDIIHDTQFDYYGLQLATASSDRTIGIHLAREGAPLNRVATLTGHEGPVWMVSWAHPRFGNLLASASYDQKAIIWKEVHQGAPKWMPVHVIDIHQGSVNAVQWAPEEYGPAVATASSDGTVAITTYRDGCWQPSMKLSNNSNQIAHAMGATSVTFAPFKSELSKHVMVASGGCDGHVRLWVSGCSPERGLEFELHQVIEAHADWVRDVAFCPTSSASRFVILASCGQDKTVVMYRKPWNQLCAEINEGVSQATEWERSVIEFAEPVWRLSWAPSGEMLVVTNAKSEVFVLREGADFTEPWIKLPLKDFQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0L9</accession>
    <name>A0A088S0L9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.57</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_343220</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Displays methyltransferase, positive regulation of the poly(A) polymerase and transcription elongation activities. Involved in the modification of both mRNA ends and in intermediate and late gene positive transcription elongation. At the mRNAs 5' end, methylates the ribose 2' OH group of the first transcribed nucleotide, thereby producing a 2'-O-methylpurine cap. At the 3' end, functions as a processivity factor which stimulates the activity of the viral poly(A) polymerase OPG063 that creates mRNA's poly(A) tail. In the presence of OPG102, OPG063 does not dissociate from the RNA allowing tail elongation to around 250 adenylates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with poly(A) polymerase catalytic subunit OPG063. Interacts with OPG109 and OPG123; these interactions might help linking transcription to capping and polyadenylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Virion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.57" evidence="2"/>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702748.1">
        <property type="nucleotide sequence ID" value="XM_010704446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0L9"/>
    <dbReference type="GeneID" id="22578827"/>
    <dbReference type="KEGG" id="lpan:LPMP_343220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340038600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_343220"/>
    <dbReference type="eggNOG" id="ENOG502QQRD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270189at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004483">
        <property type="term" value="F:methyltransferase cap1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20760">
        <property type="entry name" value="capping_2-OMTase_Mimiviridae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000176">
        <property type="entry name" value="mRNA_MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025804">
        <property type="entry name" value="Pox/kineto_cap_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01358">
        <property type="entry name" value="PARP_regulatory"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51612">
        <property type="entry name" value="SAM_MT_2O_PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIO01948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="542" mass="61807" checksum="0D5BF93F0DC7C203" modified="2014-11-26" version="1">MGSGYLKRKRKRQELLNDFYSALWSSSPGIAGDQFSKLVKRTVYHYPSSLPFPDLLDDDFPAEPYRSRNKDIKSAIHWGQRKLLLSEIQLLCMYCRPGVSYHIVYAGAAPGTHLAFLDEMFACRHTWELIDPGQFDRAVLEPRANFWLRNEFFTNATAYSINARRLTEVLPALGFVYQHVAVESVQAEKKAIHEQLQGIVGTLDVARGTEDIPAMYEAPLSLPKGLVLLVQVALERNKPLLFISDIRSGSVALPNFEDHVAENMRAQECWTNILHGEHSMLKFRLPYTSKSTKYGGQGVVRETRLIREDGTVPYLRGDLLLPIWTRPTSTEGRLVVPQGAFQKDYNVTHVEDQFFFFNSRVREQVHFNHLVVHDDKLDHHYDAAAEVHCLLTYLRFMCPELKAAKTGDLRKEVLRVAHSITEHLGITFEDAARRRDALMINQAKRNQSKAVVDHKDDADGDEEAEDQEAKSAVFNMCAGSSESASVADTTAPEPRSEWELTMQRLVRLSTYDRNRPVWTRNVREEEHSKASGFWVTTKMPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0P7</accession>
    <name>A0A088S0P7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="7">5.1.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Pentose-5-phosphate 3-epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_343550</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="7"/>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702778.1">
        <property type="nucleotide sequence ID" value="XM_010704476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0P7"/>
    <dbReference type="GeneID" id="22578860"/>
    <dbReference type="KEGG" id="lpan:LPMP_343550"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340043000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_343550"/>
    <dbReference type="eggNOG" id="KOG3111">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1927044at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000004">
        <property type="entry name" value="Ribulose-phosphate 3-epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004076">
        <property type="entry name" value="PRK05581.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="RIBULOSE-5-PHOSPHATE-3-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIO01978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="253" mass="27930" checksum="7DEE80592A59A9B6" modified="2014-11-26" version="1">MATKFNHQDKSTYPNGRDKRQPIVPIISPSLMVADQTKLLLESLDVLSENGGSADWIHVDIVDGHFASNFSFCPATVSDLRKHLPNTFLDCHMIISNPIHWVDKFAKAGASTFVFHYEATEDPVAVCRKVRKAGMVAGVALRPDTLAERLFPLIDAGEVDMVLVMCVQIGFAGQTFKPETVEKVRLLRQRYPHLLIQVDGCITLETIDLVAAAGANAIVPGRAVFKSNDRKGSMEKLRSSIQKHITLRASSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S150</accession>
    <name>A0A088S150_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_010770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009370">
        <property type="protein sequence ID" value="AIN95176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696718.1">
        <property type="nucleotide sequence ID" value="XM_010698416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S150"/>
    <dbReference type="GeneID" id="22571806"/>
    <dbReference type="KEGG" id="lpan:LPMP_010770"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_010012000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_010770"/>
    <dbReference type="eggNOG" id="ENOG502SCIB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267186at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="488" mass="51567" checksum="331D425915A28B81" modified="2014-11-26" version="1">MASPLPTRRGAAAPSARSTLSSALSASLEHVCRPVATGTRCASGIPEAPTMPTASSGNSVSAVGDVRRDGIQGAVYARSTTQTSSHRRPAQDLRADTEGSVSAAGTVALAAEASSFRDQAPRQPPEQQQQQQSGTTSFTSLPPGSSPTSYHSDADVARVRAALAEAGYPSPSWDDIERVLAQLSATHNGGGGSAAARHGNAVPPPSATCLPQGIEPEDLGEEGQRVAYYHDSHGAAIPPPAASSPQQQRQKEDCPTGSSSLLHYLEPSLRLQRYIQLRERELEELCLRPSLGSLHTQQQQRRRGSAAAGPQAQRTRGSGAAVGASPAALGGVQVSAMATHHRRAANIVFDATGDQRFRFFPTTRTPQGISTLATVAPVPRTSTSTTSTKVLMGAATATRLGSYHNYCHCPRPNSCGTVGGQVSYLDPAGRTLRRKADPVKRGEQMRLLWAQDSFLSQRDRPREAWRTRQITMAYGQDTSSSGASIRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1C4</accession>
    <name>A0A088S1C4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Elongation factor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_350180</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702958.1">
        <property type="nucleotide sequence ID" value="XM_010704656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1C4"/>
    <dbReference type="GeneID" id="22579047"/>
    <dbReference type="KEGG" id="lpan:LPMP_350180"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350006800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_350180"/>
    <dbReference type="eggNOG" id="KOG0469">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="274892at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16268">
        <property type="entry name" value="EF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000010">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000006">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000003">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000058">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF10">
        <property type="entry name" value="EUKARYOTIC TRANSLATION ELONGATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="17"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO02158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="845" mass="94218" checksum="D34927335D0EFFF3" modified="2014-11-26" version="1">MVNFTVDQVRELMDFPDQIRNMSVIAHVDHGKSTLSDSLVGAAGIIKMEEAGDKRIMDTRADEIARGITIKSTAISMHYHVPKEMISSLDDDKRDFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCVEGVCVQTETVLRQALTERIRPVVFINKVDRAILELQLDPEEAYQGFVKTLQNVNVVVATYNDPSMGDVQVSPEKGTVAIGSGLQAWAFSLTRFANMYASKFGVDELKMRERLWGDNFFDAKNKKWIKQETNADGERVRRAFCQFCLDPIYQIFDAVMNEKKDKVDKMLKSLHVSLTAEEREQVPKKLLKTVMMRFLPAAETLLQMIVAHLPSPKRAQAYRAEMLYSGEASPEDKYFMGIKNCDPAAPLMLYISKMVPTADRGRFFAFGRIFSGKVRSGQKVRIMGNNYIYGKKQDLYDDKPVQRSVLMMGRYQEAVEDMPCGNVVGLVGVDKYIVKSATITDDGENPYPLRDMKYSVSPVVRVAVEAKNPSDLPKLVEGLKRLAKSDPLVVCSIEESGEHIVAGAGELHLEICLKDLQEDFMNGAPLKISEPVVSFRETVTDVSSQQCLSKSANKHNRLFCRGAPLTEELALAMEEGTAGPEADPKVRARFLADNYEWDVQEARKIWCYGPDNRGPNVVVDVTKGVQNMGEMKDSFVAAWQWATREGVLCDENMRGVRVNVEDVTMHADAIHRGGGQIIPTARRVFYACCLTASPRLMEPMFVVDIQTVEHAMGGIYGVLTRRRGVIIGEENRPGTPIYNVRAYLPVAESFGFTADLRAGTGGQAFPQCVFDHWQEYPGDPLETKSLANATTLAIRTRKGLKPEIPGLDQFMDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1X0</accession>
    <name>A0A088S1X0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 6</fullName>
            <shortName evidence="5">eIF-6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EIF6</name>
        <name evidence="6" type="ORF">LPMP_350920</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <text evidence="5">Shuttles between cytoplasm and nucleus/nucleolus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703029.1">
        <property type="nucleotide sequence ID" value="XM_010704727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1X0"/>
    <dbReference type="GeneID" id="22579121"/>
    <dbReference type="KEGG" id="lpan:LPMP_350920"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350014900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_350920"/>
    <dbReference type="eggNOG" id="KOG3185">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4155914at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00527">
        <property type="entry name" value="IF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.75.10.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00032">
        <property type="entry name" value="eIF_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002769">
        <property type="entry name" value="eIF6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00323">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10784">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01912">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006413">
        <property type="entry name" value="IF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00654">
        <property type="entry name" value="eIF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO02229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="249" mass="27141" checksum="E14FC04A0780F5A8" modified="2014-11-26" version="1">MTLRTRFESSDDIGVFSRLTNAYCLVAAGASQNFYSVFEQELANHISVVYTSIGDARVIGRLTIGNRHGLIVPSITTDQELQHLRNSLPDSVKVQRVEERLSALGNCVVCNDHVALIHTDLSRETEEVIRDTLQVQTFRTSIAENALVGSYAVATNKGCMVHPKTPAQDMDEISSLLQVPVVAGTINRGNAAIGSGLVVNDWAAFCGLNTTATEITVVERIFQLRRETVGGDEGNLLQNVRETLVDELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1Y7</accession>
    <name>A0A088S1Y7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNAJ protein-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_350640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703001.1">
        <property type="nucleotide sequence ID" value="XM_010704699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1Y7"/>
    <dbReference type="GeneID" id="22579093"/>
    <dbReference type="KEGG" id="lpan:LPMP_350640"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350011700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_350640"/>
    <dbReference type="eggNOG" id="KOG0712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050817">
        <property type="entry name" value="DjlA_DnaK_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="171"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="260" mass="28103" checksum="92F5101851F3FD45" modified="2014-11-26" version="1">MMTSNYNSTSSDTFAVDDLFGSISANTSASPSGTSASPLHFSSFAPATPKVTSSATTDTVSSVLNDLFAAPTIASTGQSENYGKPGAMQAMIYVDRSSDSAEDGVTNLFDLSKPVKKDKYNNAESLLEAFERQGKKSVSGGRYADEGETLANLTRNKDDNKVRARLLALMNYYDVLGVAPTASEEEIKHSYKKKALELHPDRVGRNQTPEEAELFKVITKANEVLSDAEQRRLYDTSLVDVAGQSATTASAADWWNHMQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S202</accession>
    <name>A0A088S202_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CYC2-like cyclin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_050690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="AIN95511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703833.1">
        <property type="nucleotide sequence ID" value="XM_010705531.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22572147"/>
    <dbReference type="KEGG" id="lpan:LPMP_050690"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_050011500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_050690"/>
    <dbReference type="eggNOG" id="KOG1674">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="337735at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF108">
        <property type="entry name" value="PROTEIN CNPPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="842"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1057"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1223"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1279"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1367"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="276"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="537"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="845"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1057"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1228"/>
            <end position="1246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1421" mass="151486" checksum="ADF07A1FD3CFD1DB" modified="2014-11-26" version="1">MDCVGACPPHHRRPSPLAHRPPTSVSGGISGVDSSGTNSARRACSVGPAALSANPADSPRSPYAELQQQPPTTAATSAPLTTAAHASLFSQADRHQDRHHLQGRTDAGAEITTPSQQQQQQVQYTKHLSLSTLSGSASNLTILIRSNTTASVTTAATDSSEYSTPLSGISSYKQQSQRARTQRVVETNYLYLNPCSSLRPSLGSRSSSHARENEDDEVTAEDDVASAACVDGAAVAGNDDDHHHHQHQHRRHGDPLLQQHGIRCSASSSKRPRPLPQSRLSPQPQPRQQQADVEDEEEESHLLHSRSAGMRIPDLSAFGEASSTRPATATATAESGSNSRDGISPRRNSNDSNSHPVSHPYPGWGSSRSTNGNGTHARVFDKVEYEEDQEVRRVLHPPPHLWRHEERGDGKCEPQDATASMTITPGGDAAVKSMSSACLSAPDATPVVPPPKRFATGEGEAVALDDLRYVCGSSTAGALSRMATASVCANEEDTYRHQEQPLHAFTTLQDDECGRASQQQQQQHQQRGSRSRKARVAGASSNCGVSGSSSSSSSRSRLASRRHPNDSITAGIPYDPSRFPPPSQPPNLAAPVTAAKEVSPVAAWEHGSEARRISTSQPSCATPPDTQQQQQQQQSLQLAGANDSAALVPARSPIKLIETRYAFLALSFMMRMLCKLHKGEPIPSSDFHSHCIPPMTVTMYVQRLVRYCACSGEALLCAFLLLLKYVFHSGHPVTIYNAHRLLITSIVLGIKLRDDVYYSNVYYGRIGGISGREMNKLELLFLEKLEWETQVHEDEYVALLDLLTELGIDAEPTSAQLEAFAAAHPDEAAAYVLDEEDNEVAEASTKLQQQGADSSAGSPMKGTATTAADLPAAEQQRLKVLCGAYRLHQWHTIVVPWLACLKQSTFDKAKANAVAAAAARKEEGLRWQQYHREDEASALRHLPPSSASSWISPLSVQKRAISSTTTTTAASAATAAAAAAAWASEPSYQSSCFLHDGSNVPYRSSSSAVVIGGGDVHSTATTSNGNSGFENPHHSVTKFSNDANGGCLGTSTATATPAAVSQGSRHASSSQSHTHCGSATLDRPASPSSSVQCPSRQQHTISGVASSSYCCYYGANSGHQHSGNGTDEAHTLSQVRYHTAAATAVAAMDRSPRAASAHFDITNRAAAALMDATAEPRQHTAQTQHQQLPSVGGTTAQLTSPVSFTTPGSGINVNAQPYYYVSSRMRKQQQQQQRQAAAASPASGDRSATRPGNALTIDTTTAMTQATAVSPYDYVASAQRPSSSTLEGGRGARSPSSSFTSPRCVDSMARFSTYAATSTDAVAGHPSQPSGLSSGIETVLSAMKMSGIYGGTSSACVHNFPTRTVDSCRRPDGGSEQATLTHVPRQPPHSDQQAQVHRRFAFSSQHSLGKKRSKPDSYKDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2B9</accession>
    <name>A0A088S2B9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thioredoxin-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_340360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01665.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702465.1">
        <property type="nucleotide sequence ID" value="XM_010704163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2B9"/>
    <dbReference type="GeneID" id="22578540"/>
    <dbReference type="KEGG" id="lpan:LPMP_340360"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340008700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_340360"/>
    <dbReference type="eggNOG" id="ENOG502RZ6K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000383">
        <property type="entry name" value="Thioredoxin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO01665.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="613" mass="65963" checksum="1E39F6BC594B9E8B" modified="2026-01-28" version="2">MLGFGTTLTEQERAVKRLKIDSPSASLECEDNSDNSTYVPHIVEVNPAPTDVHCTSLPSKQIGTSAVEAVNGASPEEVSLTNSSRSRYSSDDDGNGKDEDANDDLLSSPVARQCSSDTWRLTRTPMGSTLRATSTIAGGVASRPLPITTNGAITTLRSLGQLQTLVGSRNTASAKDNAHPSLRLKPGETVMLLLYFDETSLRSLINGATTELSQMRVFTLNLAKLPPQDYEVTPEKRLGAGGCTNSPDASVRARREGGTAAPAAGVTQATTHDSEDENEEELVLTVHPMAVSTAAAAETSAIAEKERLPHASVSVSGALTLDEVSSVSCLSVHLHHASDIISDKVHQMLAVDTILNPQASQQQRAHGNSDGGAGVVGKEPLLFPAMIVWRAAGAPREEYPPGPPQTYSSQPPPTQAELFCDRLSTEGGPLVVKEATGVDQVHSLTLFRPVFTMEHLFRTLVRTVAPSFAARGTGDKSRTVLYLGASWCPPCMRFVREMPQLMREDLPPSVVCTLKADMDLAKPIYDYFKVEVIPTFVVLDNEVLMKCYERVQCQRSSAASCNNSGGASQSDYARAIQEAFSKAELGRLQNSNRRLVSTFISKHSQSLSFDEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2D1</accession>
    <name>A0A088S2D1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Kinteoplast poly(A) polymerase complex 1 subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_352390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703176.1">
        <property type="nucleotide sequence ID" value="XM_010704874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2D1"/>
    <dbReference type="GeneID" id="22579268"/>
    <dbReference type="KEGG" id="lpan:LPMP_352390"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350030300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_352390"/>
    <dbReference type="eggNOG" id="ENOG502RX00">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="274903at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_bS18_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO02376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="325" mass="37751" checksum="2A33310395DB4DA9" modified="2014-11-26" version="1">MNRIPVAVRNAPVYATAMSQFAVCRQPWSEYLSLLTKDDAKPFHTTPQEKPAYRGRKRGREGWLFGQQVQLHYHRFPDEQLFTNLTRWRMGDTVGDVAIQQFRNAQPFDIEDKDPQGFQRPAPDVYMKLNYKNPATISRFLTRTGHMYPQDIMPLNPEAVAKVRVAKAQAIRIGLYPRFGNPFWFRSQSFRPKAYQENYDPTTYSTKHTMEHFAYNWVQTDRIRQYFKGLEELHQSRRTTVSSGGGGVTSEHKQQTQLYTLDNMSIERHRNAPSYRADVERSIKNPTVPGLMSTKGMKKKFHNLYASTSTKRMGFTNPTLGIKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2E9</accession>
    <name>A0A088S2E9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="6">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_352590</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="6">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="6"/>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703196.1">
        <property type="nucleotide sequence ID" value="XM_010704894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2E9"/>
    <dbReference type="GeneID" id="22579288"/>
    <dbReference type="KEGG" id="lpan:LPMP_352590"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350032500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_352590"/>
    <dbReference type="eggNOG" id="KOG0331">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10256233at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002928">
        <property type="entry name" value="DEAD/DEAH box helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="171"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="511"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="81"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="452"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="678"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="452"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="701"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIO02396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="717" mass="79272" checksum="54D3E1A85DE77EBA" modified="2014-11-26" version="1">MAGGPREADLLFDVLGEPAAPPLNAVLQPNAQNPTAWQALRNAPSGLSTDAGGEGRISDASTTACSQHIQQVVLQAVLDPLRSPPSQIDGSESHEAKRRESVAPPSQTELSSQYKVIMVDALGMPVDLPRGAPQSFEDLLQLSPSILQTQLQKLMERKHYRTLTPVQAAAMPFMLEYRDLLCIAPTATGKTLCYVYTALLHLLLKDMGHRPAVAATTTAGNEDSAVSLNRRQVETFLQEKIDKGEVCPYCELSISEVRVCPMTGFPHPSVSELETSLALRSKERRAMRLEELQSSVAEPRVLVLVPNSQLASQVAAVFRSLHCDYRIHCIVRASSTEEQRKYLQALEGGVDVLVASPETILPALYKHKLSLKRVQTVVMDEVDDIVSVNHFEPMKIILGALPKGALRPQRLLLGASLPPVAYGMIKTKMLLPSHRFVLVDLKTQAEQSRAAHSTLASSALSSSSPHQPNLGENGDDPAAALSATVTGGLLTARTNLRHLVFMVGRAEKVQKLAWLYETGKLNPDQRTLIFCNTRHNVAYVCDKMKALVSQVNFTTLTSHASSTAREGVLKMFRTGVSTALICTDLLSRGIDFQGVVYVVHYDMPADMETWTHRCGRCGRGDSLRGRGYTYTFFQPENIKLAKPLVGYLRQHQQLVPPKLREYAKQSFIDLFNNSLFHHPTRPHRKDDPQNSTPVLGRGTRRFPDYKQDTIHKHFRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2G9</accession>
    <name>A0A088S2G9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Elongation factor-2 kinase efk-1b isoform-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_354660</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703398.1">
        <property type="nucleotide sequence ID" value="XM_010705096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2G9"/>
    <dbReference type="GeneID" id="22579494"/>
    <dbReference type="KEGG" id="lpan:LPMP_354660"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350054900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_354660"/>
    <dbReference type="eggNOG" id="ENOG502SK09">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5987862at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031037">
        <property type="term" value="P:myosin II filament disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903013">
        <property type="term" value="P:response to differentiation-inducing factor 1"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04515">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.200.10">
        <property type="entry name" value="MHCK/EF2 kinase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004166">
        <property type="entry name" value="a-kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051852">
        <property type="entry name" value="Alpha-type_PK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45992:SF2">
        <property type="entry name" value="EUKARYOTIC ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45992">
        <property type="entry name" value="EUKARYOTIC ELONGATION FACTOR 2 KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02816">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00811">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51158">
        <property type="entry name" value="ALPHA_KINASE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Alpha-type protein kinase" evidence="7">
        <location>
            <begin position="134"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-type protein kinase" evidence="7">
        <location>
            <begin position="475"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-type protein kinase" evidence="7">
        <location>
            <begin position="856"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO02598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1134" mass="126912" checksum="573F5766AFDEDED0" modified="2014-11-26" version="1">MKGESAAKGEPESSETQSKANHGLTNQSNTRGKTASDTAGPTSYSGTMPGQKTYMDVDQASICNDAASLLWKLDAGSSTSNLPITDKASSMKDDDDFIVLSSNKRISAAALVCYVQTNRIGDAAPVIVRGCKYVFDNCTRRWLTHPVTVRVLHHNRGIHQDNYFATFAIELLDTGKPAVPMFARVYRHNIDGVVETDYYSLGQAQALCEEFARDYTRTDARHGYLKFHMPLLTNRVVVRLDLHSVLDPAIRHSRRGFFSYRTQDTRQILFLMEPNTIACETLGVSFASLEVEKGKRYERGDSTWLRDIYSDIAEGFSHFTYVRSRGCMVAHGLVRSNGYLLDPLFHTTDRERFRMGDGGRRAMSKWFERHQCSDTCRALGIFNASEDCKPFKNAPLFVNPLDMEENHYTSYLRSIRQMPAAVRMDTVHFSDEEAEEAVLSTVVGRSDLTSTTNANPLVSNSSAPLKVTCDAVKYVFLPSCDKWMEVPMRLTVCTPTVPVAVNDKYVSFTIEEMQEKGKPVPMRARFIPRRDARDADYYHVGDAYYLCVTLGQAFRKYRSNSVFERELDFYAVYTARVPKENIPDSVMPVMDDSSFFGRTTADSGDVMFLVEPEFQPLIPQHASNTGDMAKDAEGFDDLMLRQIVDAFSHFTLHKSGNYLLVCHLKCEHGLLKEPNINTSNGCGFGTLNGGQVGIDAWARMHKCNDVCKFLGMEPVPRRLKLYDISASQLMRYINLVQAHAMGTGCVFTLASPWCRMSDRMLPAAAATPNNETEGVPARFAAGASPATVGVTSFARPISSNGDEITLRPWVDDNRSPGAATAKKSAAQRRTLTQQELLHLQSKGINTKYIFSATRYNLNIDDLTWTSKRIFVRIVNPERGIGQGGMRVCFEITEVDPVACKEVVMVAKMYRRTIKNVVEKDYFTSVTVQKLSALFAKEFNHERKEDAPLRLNVLEGAVVALDRAVLSPELLAKRTGFFSYRTEDTKRAMFCMETKLAGPFTKYSGNMGEAYPTNECRLSLSAARERTMIFETVEALSHYSLERSGGGLLVCDMQGVKNDLTDLEVHTYDGQGLGVGNLGARGIQKFAVGHRCTSVCRSLGLQKLYNQQRTVTESVRMTNRFVVIFERSKEIANME</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2H3</accession>
    <name>A0A088S2H3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Iron-binding zinc finger CDGSH type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_341240</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702550.1">
        <property type="nucleotide sequence ID" value="XM_010704248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2H3"/>
    <dbReference type="GeneID" id="22578629"/>
    <dbReference type="KEGG" id="lpan:LPMP_341240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340018400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_341240"/>
    <dbReference type="eggNOG" id="KOG4605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="15717at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.90">
        <property type="entry name" value="CDGSH iron-sulfur domain, mitoNEET-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052950">
        <property type="entry name" value="CISD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018967">
        <property type="entry name" value="FeS-contain_CDGSH-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042216">
        <property type="entry name" value="MitoNEET_CISD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46491">
        <property type="entry name" value="CDGSH IRON SULFUR DOMAIN PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46491:SF3">
        <property type="entry name" value="CDGSH IRON-SULFUR DOMAIN-CONTAINING PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09360">
        <property type="entry name" value="zf-CDGSH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00704">
        <property type="entry name" value="ZnF_CDGSH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iron-binding zinc finger CDGSH type" evidence="6">
        <location>
            <begin position="29"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Iron-binding zinc finger CDGSH type" evidence="6">
        <location>
            <begin position="73"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO01750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="120" mass="13813" checksum="2405A8DCDCD5C7D1" modified="2014-11-26" version="1">MQRCRLLAASWKTKVDPKNPRRIVQLPNRIPCMVPLEAGTKYYWCSCGLSKKQPFCDGAHRAYNEEHKTDLKPKEFTVDTSKKYLLCRCKHTDNSPYCDLSHVGVLFRTIVGIEKIPGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S304</accession>
    <name>A0A088S304_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rab-like GTPase activating protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_356240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703553.1">
        <property type="nucleotide sequence ID" value="XM_010705251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S304"/>
    <dbReference type="GeneID" id="22579652"/>
    <dbReference type="KEGG" id="lpan:LPMP_356240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350070800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_356240"/>
    <dbReference type="eggNOG" id="KOG1102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="295078at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000016">
        <property type="entry name" value="TBC1 domain family member 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="162"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO02753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="427" mass="49395" checksum="E570936CDB64C6E7" modified="2014-11-26" version="1">MVVAGRIVILPHAEEVGLRHGSAPATITSTTGRLNLVVPDRRGEENREAVSYDRSNGCDGTEECSTTSASTNRPPRQHCSQATSSPEMSAVSAHCRATAMRRDTYEFHDMFGFCVTEAEKAAEDYERRKKGYSGVYLARWQYMLTCWDKVKHDTLKKYCRRGVPQPMRCIVWQHLLRSWGMRERFPGTYMSLRSQPLDSKDIEDVIARDLHRTFPTNRLFREGESGQGLEMLRGILHAYANYNTGVGYCQGMGFLAATLILQVEEEEDAFWAFVALMEDERYNMKGVFSHNFPQLQCAFHVFEVLMRQTMPKLYAHLHDRHQIQPYLYAVHWFMTIFTYYFNFGLVSRIWDMFLCEGWKPVYRIALGLLKLEKQRLLSLNTETELLLALKSIQESKRPVEVLRAALKISFKTDYLKDVVADYNAQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S322</accession>
    <name>A0A088S322_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Inosine triphosphate pyrophosphatase</fullName>
            <shortName evidence="8">ITPase</shortName>
            <shortName evidence="8">Inosine triphosphatase</shortName>
            <ecNumber evidence="8">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="8">NTPase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">XTP/dITP diphosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_354750</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ITP + H2O = IMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>XTP + H2O = XMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="8"/>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703406.1">
        <property type="nucleotide sequence ID" value="XM_010705104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S322"/>
    <dbReference type="GeneID" id="22579503"/>
    <dbReference type="KEGG" id="lpan:LPMP_354750"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350055700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_354750"/>
    <dbReference type="eggNOG" id="KOG3222">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6288734at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009204">
        <property type="term" value="P:deoxyribonucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.950.10:FF:000022">
        <property type="entry name" value="Inosine triphosphate pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03148">
        <property type="entry name" value="HAM1_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027502">
        <property type="entry name" value="ITPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="RdgB/HAM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067:SF9">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE/HAM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="81"/>
            <end position="82"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="176"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="208"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIO02606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="247" mass="26577" checksum="B30C85C627250C58" modified="2014-11-26" version="1">MATWGKVYLVSGNKGKQMEVQRYFTQAQLMVEAVNINLSETQNSSAEKISWDKAVEAYRVVNKMPVGEPLCHGGTPVLVDDTSLEFDALCGLPGPYIKWFLDRLGVEGLLKMVKGFAPPDEEDSTEAAPAYRRASAVCIVSLCYGVDEATGQPLVQQFRGVCRGALPAGPRGGVGFGWDSIFAPEAQTPAYAKTFAEMSVDEKNTLSHRAKALQMLTEYLQNSRAGTQGGGACCKGTPEEKVGVNGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3B1</accession>
    <name>A0A088S3B1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_344660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702885.1">
        <property type="nucleotide sequence ID" value="XM_010704583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3B1"/>
    <dbReference type="GeneID" id="22578971"/>
    <dbReference type="KEGG" id="lpan:LPMP_344660"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340054400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_344660"/>
    <dbReference type="eggNOG" id="ENOG502RKET">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269279at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="1">
        <location>
            <begin position="271"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="391" mass="43683" checksum="FCA7788E84E0A445" modified="2014-11-26" version="1">MPEGRAAAVTATSGWVCSNCKVEQAEDNTYCQVCQFARPLDRYGIPQIFSGYFVHFNGIIPRTLMHPSHSVEWRMAERHGATCCTTFDPSVVNIIVYRPGYERSEKCRICIERYSNVSCVPIGWMLDSLLQSRQIHPSLYRLTSVPAVANATVRGTNLPHHHHPFYQINKREYAIATSFPAPETKVAKVKKVKEVEPPTDMEVTTDMGGILPPFFDLQQPQYTVMDVYDAVVACATGMSADTGDDENDKMEVRKTKAGIELISSQQSYNRVNRALFTGMNVVLSPSLTEQKPLLMAIERCGGKITENRGSLEETVQSGVTHIIYHHNDKKDEIMVEAVHLIATTTPGLQLAQSNWLEDCLILGEVLPLQGMYTPTPKLLETLSKKYAKANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3J3</accession>
    <name>A0A088S3J3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome b5-like steroid binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_356860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703614.1">
        <property type="nucleotide sequence ID" value="XM_010705312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3J3"/>
    <dbReference type="GeneID" id="22579714"/>
    <dbReference type="KEGG" id="lpan:LPMP_356860"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350078300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_356860"/>
    <dbReference type="eggNOG" id="KOG1110">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="547796at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000003">
        <property type="entry name" value="membrane-associated progesterone receptor component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF76">
        <property type="entry name" value="CALCUTTA CUP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="2">
        <location>
            <begin position="38"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO02814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="147" mass="16452" checksum="BCF703ECB5633E97" modified="2014-11-26" version="1">MSWWGFWNRFFGSKDGEDTNDSGNTAAKPAEPAEVKSFTAQELAKFTGENGKPIYMSVKGKVYDCTSGAAFYGPGNSYAVFAGKEVSRCLGKMLISDEEANANWDDLAPEHMQSLDEWAAKFDSKYPVIGMFEPDEEYYVRQRKLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S4D3</accession>
    <name>A0A088S4D3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_353470</name>
        <name evidence="7" type="ORF">LPMP_353480</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703284.1">
        <property type="nucleotide sequence ID" value="XM_010704982.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703285.1">
        <property type="nucleotide sequence ID" value="XM_010704983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S4D3"/>
    <dbReference type="GeneID" id="22579376"/>
    <dbReference type="GeneID" id="22579377"/>
    <dbReference type="KEGG" id="lpan:LPMP_353470"/>
    <dbReference type="KEGG" id="lpan:LPMP_353480"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350042700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_353470"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_353480"/>
    <dbReference type="eggNOG" id="ENOG502S9KJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268566at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002673">
        <property type="entry name" value="Ribosomal_eL29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12884">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12884:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01779">
        <property type="entry name" value="Ribosomal_L29e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO02484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO02485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="70" mass="8003" checksum="02E374D5EFF0D7DA" modified="2014-11-26" version="1">MAKSKNHTNHNQSSKNHRNGIKGPMPLHLCNSKRGGWLPALVNTRRVRKHNQKAALKRRRERIAAFAAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S6M1</accession>
    <name>A0A088S6M1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_171280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697819.1">
        <property type="nucleotide sequence ID" value="XM_010699517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S6M1"/>
    <dbReference type="GeneID" id="22573871"/>
    <dbReference type="KEGG" id="lpan:LPMP_171280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170019000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_171280"/>
    <dbReference type="eggNOG" id="ENOG502RZXN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273177at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="516"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="585" mass="62602" checksum="46A8BAE16E1D7402" modified="2014-11-26" version="1">MHQQLSSNSCSGASRVGSTKYAHSPYTYRTSIDDGHFSPIRDPGCRQESASLPAYLSPRSFNRSASAQEAPANPVLKSVQNESAGQQLSQPSTPLSPSSGGQEYSQPIQVGSAPNVHPRYRRRINSPITQCGSNDSGSRSGFPNTPPSSLPPRFPFAPREDDTSAFARVESAPVQGHYSPPQYGMPLSGSFRSAAVEVDRRSQSPNPYYTAQGTPPPLPPLPPHVPSGIPGSLYGAQTPSRCASPTIVNGAAISSYAPASFSVPLTMVPVMNSGGSESYHGSLGGRGGLQSPGYVDPRSNHCFSSVMGCSNGAHPQSFVSAKNQKKHQSGPFPVRKYPNKSNSSSNSNRVASPPLGGVFMSSGPAGVTHRAEAPLFSGSYDTTMKTLSAMADETMSFSSKSSSSLSSIRDDLLLCPSDEECTLINDRKHQKKYAHTCRLHPCYHAHVVRHAKLFRHSPGQVLLPEGVSANMKISTHALASVNFSAISPEAPNAYRIYVSHGEKSYEIFGDWASVKVHTLKRYLHQVYHIAPTAQILSVLKTGNAMDDDISTVKAFGIEEDSVIQLHSNIEGSTDFGRIGISLDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S825</accession>
    <name>A0A088S825_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alba-like DNA/RNA-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_202300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone-like Alba family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698433.1">
        <property type="nucleotide sequence ID" value="XM_010700131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S825"/>
    <dbReference type="GeneID" id="22574439"/>
    <dbReference type="KEGG" id="lpan:LPMP_202300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200028400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_202300"/>
    <dbReference type="eggNOG" id="KOG2567">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="424402at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="entry name" value="Alba-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051958">
        <property type="entry name" value="Alba-like_NAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002775">
        <property type="entry name" value="DNA/RNA-bd_Alba-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13516:SF4">
        <property type="entry name" value="FI09323P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13516">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01918">
        <property type="entry name" value="Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82704">
        <property type="entry name" value="AlbA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA-binding protein Alba-like" evidence="5">
        <location>
            <begin position="28"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="130"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN97726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="198" mass="22011" checksum="C64E141D39E8D39A" modified="2014-11-26" version="1">MPQRPSREEYRRVRENRENHERTEGAENEVRVTATHGQHSYISYVIAVLNGEDGKARNDTVKISGMGGAIYNAVNIAEIVKRRIVGLYQVTELGSELVRDEYEPIDRNQNPDNVVVERKVSTILITLSRNPLDKTNPGYQDPISESEVTEQEKRDHTMSRRGGRGGGRGGRGGSRGGRGGSRGGRGGIGVDRRDDREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S9Y9</accession>
    <name>A0A088S9Y9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Beta propeller protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_230040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699163.1">
        <property type="nucleotide sequence ID" value="XM_010700861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S9Y9"/>
    <dbReference type="GeneID" id="22575208"/>
    <dbReference type="KEGG" id="lpan:LPMP_230040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230005200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_230040"/>
    <dbReference type="eggNOG" id="KOG0310">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="431715at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018983">
        <property type="entry name" value="U3_snoRNA-assocProt_15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924:SF26">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924">
        <property type="entry name" value="UTP15 U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09384">
        <property type="entry name" value="UTP15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="113"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 15 C-terminal" evidence="7">
        <location>
            <begin position="344"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN98456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="478" mass="54099" checksum="169412C485A0093D" modified="2014-11-26" version="1">MITDWTLPLRKVPTHATKDPSIAWNTVHLCYEQRFFGQITSLRYDHAGLLLGGTSTNQFALLRVPQKNGVVVNEQTERKNYSIRFREDDKLYIQAVDQRVVVRSPETAFERQYLGHSRDVRSAIFIGRHNFASASDDTTVKLWDLMSDDELGAARIHTDYVRCLEPYSGGSFLSGSYDHRVNLWDPRTGMDAPLQTSGGVITQAVEALCFVPNEEIVAVGAGDRLVIFDPRKGLGTPLFQGSFHTKSVVAVAYSEKLRSLLTGSLDCRVKMFSLDGSELRCIANKRFENGVTSLAVHPSSTEYAVGSTTGELSVYRFKEAEGLVDDLPEEFVLEKEKPRSKEQVMRDKMKEVQFLLGRYQYGKALKTALYSRHPDVLVSTFEELVRRGALHIALNNQNDRTVVRVLRFATHYVEMPQFTDTMFAVFETIFDIYSAYVGKSVFFHREILSAQKKIGASLAVMQRMERTMGIMEMIVHSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SB41</accession>
    <name>A0A088SB41_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Centrosomal CEP44 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_250060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699578.1">
        <property type="nucleotide sequence ID" value="XM_010701276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SB41"/>
    <dbReference type="GeneID" id="22575654"/>
    <dbReference type="KEGG" id="lpan:LPMP_250060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250005400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_250060"/>
    <dbReference type="eggNOG" id="ENOG502S8NA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="259598at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="18883" checksum="A75945D8B31CA0FE" modified="2014-11-26" version="1">MELASSFSLLHAKLSKLGFRDWTSVSEGDVMTGNPHTYALFLRFLYHRFPAATAALICKHEWFILEHSDVNIGAATVRLLAVEAGETHGISGAQFSRCKYASAKVAMCHSLLRLLRSLTPQSLPTRNLARVPVVSRTPKVLCKPATVLPASSVAADMIDQRRHELNSLRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SDA7</accession>
    <name>A0A088SDA7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Homologous recombination OB-fold protein OB-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_280720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700413.1">
        <property type="nucleotide sequence ID" value="XM_010702111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SDA7"/>
    <dbReference type="GeneID" id="22576517"/>
    <dbReference type="KEGG" id="lpan:LPMP_280720"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280012700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_280720"/>
    <dbReference type="eggNOG" id="ENOG502S5KG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="251909at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058570">
        <property type="entry name" value="HROB_OB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15072">
        <property type="entry name" value="HROB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homologous recombination OB-fold protein OB-fold" evidence="1">
        <location>
            <begin position="33"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="248" mass="25870" checksum="3CEFDD4ACB2661A0" modified="2014-11-26" version="1">MNPHNVLESLAREKGVGLTHLSEISSKYSRSAKVACCGGLMTRLVTESAADSTVLLRDGSGSCYCALHGDITNRYPDVLTTDALLFFTDITVLVVSSKVPPMLIACLQNLAGLLLPDKATSTAAATASSATAGGTQSTPPRTFFPRGAMPHNDGFACSDTWQLDLLTGVQRGYDNTGMFSGSESAGGSCTEPHASAAAVSLAHPALVGERRDSAPAEKRICTENTAAPAALDVDDEDDAECLELVDEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SDD5</accession>
    <name>A0A088SDD5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_281130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700453.1">
        <property type="nucleotide sequence ID" value="XM_010702151.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22576558"/>
    <dbReference type="KEGG" id="lpan:LPMP_281130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280017300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_281130"/>
    <dbReference type="eggNOG" id="ENOG502SB34">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266511at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1253"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1434"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1446"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1466"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1477"/>
            <end position="1486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1554" mass="165662" checksum="57468787F6DAD59A" modified="2014-11-26" version="1">MKKVKYAASAAVTPHSYDRGRDCHSATAWMRQLLCRRFSTWRPLFNRTPPRPLKSFTPQGAMRSSLFPQHRCVSSQATPSDAGAPAEKLSPWEKAFDEALYMGFTHQSVVGVADSADTTPSSDLANKNVAIRVAPCIEDLTESPSAVAIEVPEDTAGASITGSETLSVTRAAKSTPLAQTPRENPRPSSGVSSPPLLPSVSQSEEERRMHLITELAFEQALYGDPVVESRGDGGATGSHSTKTPDSTSNTPTERPTGETAGVVEESREGRTVVAAGVATLASPKSFPPPPSHLPLGGSAELSKSALSPLQASRLSEEKGQPMSATAVTMPRAAFESAEAAFERVLYGDLMVEPLSGKAKVLVPSDASIAEAGREGSTSTGAPPLLPTPPTLLGTPASTRPYPDAGVADALICSAEDVASCGVAEEKPASDIRESKAEKMPQGGGDVRQLVESPVTTGVPATADGGGADRIAVKEAIPPPTVSMRCVFSLDRRDSPADQFALFNALFRVTDHHTTVVTHIDPEDRVRRCMPLLDRVSKRELFFASEWVLDLERADGTNTAPLSTESAAGFAETSAPPPFTHREVIGRSKVLRTLVFRLLRAPHRWWDQVQELVLLAVKEAAALHPSCTTSVDTAASGEDTSLKSSGAGADDAAASVVMTASDTVAAGGVIRDTTAEDVQAAMTRVFSTDPQQVHFFSDALREVLAALGHTSGTDRSLPAFEGPLGAWKAFVLTQRHLTTGVCGPHTRPFSFGEGRPTITASDLAPLQYCEAAASWDDPPSLGPLPCATAVPHRAEVCLTKGERGVDEAHAGRASLPCMTLASTAAVDAITMAWDKMSEEEQNTFLFGAESAQLSQRVRELGGVYAVFGQNNTSFEMESMLAEAETAAQLREAQEKEEAEAKAAGVGSTHALTEASLLEVMRDREAAHVRAYDVDRVVLELTNGEGVAVARLPGGRSTFLSNLAAASSARGGRTSRQQGDHGRISAVAAASNVPFQRQLQNNEDVQLAALWQRFTRASTGDLIGNLLYVRRHASLLVHEAMVDVAVQKAFWLLFFARDEVRAVTHPKRTYETLWNLHRQLVSLFVLPSTDGSPPSPAPGQVARSGEDAQAINPAFESLSLHSQVSYACFGCAHVLPQRDESAKSSYLSTLVTEPAGVGDNPITHSGVCKPYASPKDLYAALTGTYSGRVARREGATAVPSTSAVHSQVADSVRVNFETLSAFQQLAVAFCFPRNDAERDEAARLVSGRSGTTAVNALTTTTRGAADAEEDPQNERGEPSLGTGSHLTAEGKLLDDGCARQPSLHVEERIKGASKVKTHDNCSTGGDTWLQQVQCALEGSVYECLRSLRAARVLATPLPSPKHRFSDTSVILATFSNEQRRKVQRAVQDITATMIEGDTVESSVGASSLAREVLVPAKAQIKQHLMPPLDSTMADALASPRRRGRKARTTANTPLSSAMSVVRDKRQQVTETMPTNNLSLRRKRGRKPRAASCEGIDSAPEKQTAGAVLEKTKRLKTPSMERSPGHRGRNRGGERQESGVTNEEVARVMALFCEGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SF79</accession>
    <name>A0A088SF79_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_302440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701267.1">
        <property type="nucleotide sequence ID" value="XM_010702965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SF79"/>
    <dbReference type="GeneID" id="22577297"/>
    <dbReference type="KEGG" id="lpan:LPMP_302440"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300029000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_302440"/>
    <dbReference type="eggNOG" id="ENOG502QWMJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277813at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO00467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="349" mass="37019" checksum="7AA436C3C3E32E75" modified="2014-11-26" version="1">MTDAYEPPTKTACRLEVMGKVSSIHYDCVTSSCLVSTILNGTHIFNLDDTFYGANLAAGVSASSVESYPYHTMGEEPLMASCFFNAGQLFAVGSSSGSVTVVSRRSRALTSCYATPDSLPIRALSEIPTESNCLLMCTEQGAAIIDVERSQPRVSLANPAPGRAVAAVPLQRQTFVVANYDGKVLLYDTRYRSSPSSVLSLPDQITCLAASPDTSEVCVGTVGGRVFTLRCIEGAQREQAFGMSKKRSPVRCVAMDRGRIAAGDLAGRLALIDTADVPDPTVYWSAETLLRLPRQIYRAGALDRHIDTASAAAAFTSTEVTAAALAQGTAWMSFCSSKNAVSQVVAIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SFJ5</accession>
    <name>A0A088SFJ5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_303500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701372.1">
        <property type="nucleotide sequence ID" value="XM_010703070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SFJ5"/>
    <dbReference type="GeneID" id="22577403"/>
    <dbReference type="KEGG" id="lpan:LPMP_303500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300039900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_303500"/>
    <dbReference type="eggNOG" id="ENOG502R0MA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277888at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052405">
        <property type="entry name" value="Mito_Transl_Release_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203:SF1">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION RELEASE FACTOR IN RESCUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203">
        <property type="entry name" value="PROBABLE PEPTIDE CHAIN RELEASE FACTOR C12ORF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839390" description="Prokaryotic-type class I peptide chain release factors domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="464" mass="51821" checksum="E9BEAC9E3007F98D" modified="2014-11-26" version="1">MQALLARRAPVLLWSSVFSHTICDGACFVHGSGSVEKRPSRRRYAAFNTSGRCGEAKELVHAMKKMSAQDAKALYDALHPRVRLDIMRLLSEKRRKRQSDRVTSKLTKYYSVPFEKNYFFREEDVEEMSTLGKGPGGQATNRRMQTAIVKHVPSGLIVKFSRFPSLWLNRRAARELLSLRLEEHLLGPTSQLGKIRVARERRRRRQQRTLKYLSEKGARLQTKDTRRCHWLAFLTGESPLPTAAVSQMALEEDAAAVPVTTAVLFGPECNTWWPKLRAASQSTAAAAPDSTGDGGVPLFLQYLFPVAYADSSPAEREEMAACKSSKAVRTNVRRALSCFCELFGLRLRRIATSAPIEASRVVLERDGLNWVERKSRLTKNGSMTPLARACWPRVYMSVRELGMSPEARAIVVFFKKEVRTALGSASGAWAVEALQCLTEAVRRSKSAVAVQLSSGTSSPTRRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SG87</accession>
    <name>A0A088SG87_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_312390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701627.1">
        <property type="nucleotide sequence ID" value="XM_010703325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SG87"/>
    <dbReference type="GeneID" id="22577665"/>
    <dbReference type="KEGG" id="lpan:LPMP_312390"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310031200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_312390"/>
    <dbReference type="eggNOG" id="ENOG502QWR0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271685at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="630"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="832"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="861"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="880"/>
            <end position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="889" mass="97574" checksum="5A870B022201F843" modified="2014-11-26" version="1">MFYTYAEKQGNVFFDSWQMREIAFDTLRRHLYYSDCVSPEKIAYPNANNNPFPTVGASDDSLENREDTDSSLGTTGNNPAVSQLIMRPPVSPLNQRVHFNVAPPPPNDPEEVQWRKKIKVDMVVAVGKEHVFLLEDTHLKETDLFQVEIHGEVRPRAPGEIPSPGPLLCPSTGLSGLPDRCTVENDEFIRDPFFLRELYEALRYQFSNLRMERERAELASGLPVMAPNARKTQTLESPRPKNGGVFHGSRIKIILRMRTDYEFRRFVYVVQTVLGYDKLIVRPYRGLPPYDPRNGLIFSVIPMCVWHTFKSLDKAVFYSFLRGDLVGRNSSNQLYVALRGAYLCITHDSVLVMRDTGGIPRWIKLQEVRAFYYNVTSSRPFVAFLSDPGAPDIIFLPQPPIFGPEAVRRFSPSLEVLRLRHVIHETCFASLEIRRVINIEIAEASVRSFVECYERETRRSLDLDPARCYPGVLSCPLPKEQLAQVWREVQSFYATRDPAVASCAAIPLYQNNTNDTALTPDQLEALSRRLARERASRDDIVGLSYEEAYRIQAPTRRDGRLHSRHHLTPLHPDVEATTQSTGDVPEAQSDPHSNAASAGVGRDRAMATTSNHLHRTSMATVEDLEHANFQRSTGHEADADIRGGSPPRDSSGTSTVMSPTWVAVPSAAPLTTSHSTAAVSTDGNTRLPSDVAVSTLSGNVPSSSGRGGTLTHSNAGCAQLPNHRLETPQLSSSFSGGAAGLGASLPMGMSPGLVSGSFTSSQFGGNSVQYQMPGARYLSADEIVGAGSCVAVDHHTILMSETPVSTDGAVNALLANTEPNVSDIVNKSISAMQAASPSTKKRPSSAGRAVQTPRGGEGKVTPTPLSPLTTRRGRSTSRSIPHNNSSIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SJ35</accession>
    <name>A0A088SJ35_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Autophagy-related protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_342110</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:38663"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:38895"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATG2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702637.1">
        <property type="nucleotide sequence ID" value="XM_010704335.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22578716"/>
    <dbReference type="KEGG" id="lpan:LPMP_342110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340027000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_342110"/>
    <dbReference type="eggNOG" id="ENOG502S8KM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273029at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026849">
        <property type="entry name" value="ATG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="72"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="191"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="272"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="908"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="958"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1309"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1531"/>
            <end position="1552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1755"/>
            <end position="1789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1856"/>
            <end position="1880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2135"/>
            <end position="2158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2408"/>
            <end position="2446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="973"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1531"/>
            <end position="1544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1856"/>
            <end position="1865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="2435"/>
            <end position="2444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIO01837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2960" mass="314815" checksum="DB7A3D83ED5255AD" modified="2014-11-26" version="1">MNFVNTYLLLPLQRKIFKNFGHYDYQTSTFHLNEERVNEVFFDPAYNPFVDVLRETSHASAVASSKAAAATAQQQQQQHLRSFSPSVRRRNTTNDADAGLQVSPPPPSEPWIGPGPNEAAAVTVAEEARRNKELPASAPRSPSVRLLSGKIRSAGLVSFLRRVTTQKSLTVESIDLVFDVATTTIAKSTDGFPTDTSSLATQSMGVPQDSEDDTVHQRDGAPLPDPAAAALGLSLEEDEYTTPTMQHLFSRRIRRDEVGTLARSYSIEDHSCLRNKAGDPGSSPDAAGEDFGYLDAGSGSRGADGSTRPVSPKEGSTTQFHTVEDLMTYLKQQLQGVAVGVQEVRLTFCVPPAGAAGSLLCSTDSENRCSGRPHGAARPSAMGAQLRMRSGTRVLHLSCRRGLRFTVDESTGAAVEDMQCTASIQDWQCYVHVMADDGPLPSEFSLDDLVLATSTTFTAGDTGQSLRSSARDDSESAVGVPFTVRVARRGASAAADAGTTSPSPPLVSTGVPPPPKVLVEVDAAEGWSVVLSAVQMAHLVDMVKQVIGDTTGSCGDAVSAGSFSEFSSAVELPRTTTELEKQVAAASLHSGEAVTASALTATQLRAAAKYVSVHCGGCSISLLTQSVVDTNAVACAWRCALSSQQLALLDPRTYDPFQQRTAGLTLPVYEALTTAHFTYVMRDVDVLFPNIDAEAPLSPSTSLLSASGVFQQSARKRKIYRRIFDNKLADPAVTEQLARAHTAAASFNSGSGASFFLGVGSISFLEYRHATAATAAASGQRNATLPYSSSNANVGAAPFLSPSLGHSVRPAKLMHAERSPYALVIFHRSTPPLPEQVSSVGVLVPPPPPCLHIYQETIVVGVANISVQLDPGLVEVLTMYGTTVEELIRRMGCAGQGCKREPNRTAEALTGATGSSARQLSSPPLPTPSPSPMTRTRSSVKVLLESVDASIRFPLQTNRATASSEHPLDLVDGASAPTTSPASAAGAPQSLLLARLLQRLRESSLDAHCHNRALLRRHARQAKCDESGIATSPTTAKLAEVTVDSMIAVQEELGFPEDVDRRARFLPELLRFSLRDLQVVHTPSATTVSRGVDVAAPTAAVYRPASTSVKWREAVVYLQDILEQTKSELFRVDYSHEMNINVTHTSLPGLAGGAWRALERVLALQVRLGEITTTALTQDDYLLATHYVNELLLTLSRCRQRLHACRVAAAAREPASSASPGGQATMAAVVSVQSAGLLVPDEAGAASMDVSDVSRSLNMSVDGVRPSECREESFKHPAGTVAEAFAMADARTADRGSVGARVSKRVASVDIQDSTSGPKPQDSGSGYDGGTTGSLRNAVPELWRLLDTTCTSLDVHISRIRLGLFAPRLSPMGQVVGEPLYRCLPKAQRRCLVDLNCLYHLYIMELVDVSVRGLSGDGALANAGQANYARVRLGDFSLWERQPVRVPPLTSCDRRETGGETEVAAAPLLSRSYVSNPVGSGNTLPGSHGLAGGTYRDLAYYMPNPKAAYPGHRRSGNLVQLVQSYTEVQANEKEGGGRRQRDGYDVTEGDGDCGGQWVSSSSRVLSEIWSAYVRELQSMVPMAGPAAHAPLPSARESGVCEVRLLEIAMALPIAAATHCRHTTPLVPTSCSAELVPPNRRYLWLQLTGLGLHHAVAYNGDHLAAVLKQYFSGGDGTVAPVGSVVPGGGEARGAAEGLATSVLTEEPLWTTKVHVNIVNLMATYRPHGAGRSLAVLLLPRASVLIKLPGTAPASTASSEAKETIIPPEELGNVGAATRSPATSSPPPASADLSVPLKMHAQAWLHTSLPLYVCNDCDVEALVHEVINPAESDDWGVDLESAGFVRLCEVVSTATFSSPSSRTADMQESTDDADLPSVPRSASFSPTPNLFLTVRSQGLGASGPGADGGGSTREESGSTDCAYLAPAVSMHLQHVELSAFMAKDSFEVFRELVEAWGSGADLEATEAPAALVMRSGPGFEWVAEEVARSCAPMTFRVNPYLMTRDRTAEADASSRGVLTSPFGEPIMRTIASVDDYTSHCPFLPSNTSLRSSHDFESPWTVPESSQLGPAAGIGGFSASYLACRSSTSAYGYNHWLDALRASHGRDPKLYDTYQTRAAQLLDGAPWVPLRQSVHLDSSHASGVRQEGKRRDASASRPLELSTDAVSKSRRYAEVWDTISVPSDDDDKLTEEEEVAAVAPTRGGSDARGGASFLSPRLQLQRKVAAAAAEISLSSSFSDLEDMAASGAQLRWCILASGNPVASSFLSSGDVRHCGDHVVSNAVDGGTPEAAEASIDLFAACNGHPHFLSCWSRERVEAAWQRRAVRLNRLDGTDDSLLHDTAEKYLYPPVELEFFLSDCSLNLSFYEGTDLMSAAVRRQRRGYLQIVSRGASLAQAAPYIFGGDRRSEPALRAMSSNSASADPGAPSFRADTAAPAHDPSHTHDGGKKSLISRYSHSTTVDTGATWALHTVSSESSALRLERLQDRGCRSGFGDRDANKRLVLSCRDITVQMDTFSQGSEEDLWFHVVVGEVTVFDCINTSDVHRLLTATPKPPASLAAQQRRDSSDVRFHAEVSDVKHGGIGIHSGASDARQLELTGLLTSSKSVLMAASGGMTETSRASFTVSHFQQGGSELSLVIRLQPMSLTWSGASVDFVQSFFSVSASPPTSPGSSTGAAAIAALAPSVPATEAGIISGTEAPPLFYRRVVILPTTLTAAGSFESNKGVLAALSEGNSLDALRSIPVLSWISLQEIPLPIPFIRVEDCSNVAMLLQRIVEDSNCVSIRFLLTAFCCGLQPLSAVTRVGEAAKGLLLLPLSNYRGAALHHAIRTASSVFMQELLTQASGIAALLASGSYHASRSLLEILVEPQYCALTIEEPSRAAQPTGVADGWRQGQEQLRVGLQESLTMASCCTGPDGSLLRVPAAALRLLMGVSGAATTILWGVRNSQGSALRERDGHIYKKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SKQ1</accession>
    <name>A0A088SKQ1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C-4 sterol methyl oxidase, putative</fullName>
            <ecNumber evidence="7">1.14.18.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_352600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.14.18.9" evidence="7"/>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703197.1">
        <property type="nucleotide sequence ID" value="XM_010704895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SKQ1"/>
    <dbReference type="GeneID" id="22579289"/>
    <dbReference type="KEGG" id="lpan:LPMP_352600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350032600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_352600"/>
    <dbReference type="eggNOG" id="ENOG502SDX0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1658724at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="205"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO02397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="393" mass="44959" checksum="27196DB6E4A8F996" modified="2014-11-26" version="1">MESTKKPVKIPPIHTLRPCWSSVALHTAIYLLRHDFVAAVLAIFVVQPLYQQLILQNSYLQHLSTPALFTLVFAGLCHCVPWAFFNSIFFFFDSLHPQYGINGLKSNALLAPLGRRMAMYKLPRKVQQLPSAALILNTLVHTVINQYLVIPVVLYTCLVYTNSCARAPPPEAVIVGFTPEDIANYMSGRNLKKLPMRLVTITSHFLLANVINEVGFYTSHSILHSNPHLYRMFHKKHHMYTGTISIAAEYATPLEDILANAIPTVAYFSFMFFHYTREEAAESAFITSARAWPLFMTWVWARLWETYEVHSGYCFSDTWLGKIGLMHGHRARFHDFHHTHNVCNYGSGLFMDALLNTMDPYLIHRYPDKHRCTTTQHDLEAANTETDKVHKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SLI5</accession>
    <name>A0A088SLI5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VHS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_355260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703457.1">
        <property type="nucleotide sequence ID" value="XM_010705155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SLI5"/>
    <dbReference type="GeneID" id="22579554"/>
    <dbReference type="KEGG" id="lpan:LPMP_355260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350061100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_355260"/>
    <dbReference type="eggNOG" id="KOG1087">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="957735at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03561">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044836">
        <property type="entry name" value="TOL_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45898:SF4">
        <property type="entry name" value="TARGET OF MYB PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45898">
        <property type="entry name" value="TOM1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VHS" evidence="2">
        <location>
            <begin position="29"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="475"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO02657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="510" mass="55368" checksum="387ACECB6F8F3C0E" modified="2014-11-26" version="1">MVKLSFIEEIKDKAARLIPTPYMEIVEECTASHLLIPTYEHVKFLCETVNKKPEAIVDVVRALRRRIACPDVAIQHLTIQLLESMIKSCSTSFHMEVASQKGLLRDLVTAACVQPTTGRAMQAKEAALLLTLNLSIWFRGHPAEESYILTTLADDVRNQLGPNCFEGLKPESNTRMRVEVYAANRNRQQLDVRASGDDKVHGTRSQGHRRQKHHIVDAIPIDLPTSERVSAMLEACMSFSEYVNNTELNREVSLREDEVVQSYLSQVREDHIYVTILLSSNLQVDRDLLRTVADSQSAVLAKVEKSTSRPRVDAMLEKKSTLPPVPQQTLVRSAGDTEQQYSNSSTWQGTTIPPRLTPPHAKVPSENTTVTSSSPVPVAAPPASTAVSEANLFGEMQPEPQVAESMYIPPESSSTEQVSAAAPVPPAAHHEETAPVAGPALESSVEPTPNFVDAAAPLSSIGAEAGEGVKEEEAPVSASTVDPSSAPAPTAATLNGDDDFDAFLEGRTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SLR2</accession>
    <name>A0A088SLR2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rab-like GTPase activating protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_356230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703552.1">
        <property type="nucleotide sequence ID" value="XM_010705250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SLR2"/>
    <dbReference type="GeneID" id="22579651"/>
    <dbReference type="KEGG" id="lpan:LPMP_356230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350070700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_356230"/>
    <dbReference type="eggNOG" id="KOG1102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000003">
        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000027">
        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000016">
        <property type="entry name" value="TBC1 domain family member 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="4">
        <location>
            <begin position="223"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="52"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO02752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="491" mass="56312" checksum="0A94FB44A057CE88" modified="2014-11-26" version="1">MVESLRNVRGSHSSKLLPKSTVTTKTPPGELGCSEQEVELVSSPLFVVASDEEEELDRVVSPIRTPRAVRAPVSSRPDVPPSATPCPTSLTPKNVQSVGEAHLTRPLRRSQLRVAPTGGSDSDTQGEEDNADRLETPDADGRHSRPGNDCAREAEENDAEQQLVDEFGFVIDEDTKERDGKYIRRIDGKQVVRREIKWANMAADWNTTNTKMHAKLKERCRKGIPSRFRGVAWQLLMGSFHHLNSEENSGVYVALRDKKLADKEVDAIISRDLARTFPTHILFQDTGGVGQVFLRNVLHAYAGCDPEVGYVQGMSFLVAALSTQMAEEESFWALHEMMYNERYKMRELFRPGFPLLQQFFYQLERLIARLLPRLSKRLDELEIQPSFFASQWFLTLFVNHFPFRALLRVWDIFFSEGWKIIFRTGIALMKWEEPHLLTLSFEDMLLALKSLQDGKDARELLRRAHRVKFKTAELNRYGDEYWEKMGFIHRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SLS1</accession>
    <name>A0A088SLS1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_356330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703562.1">
        <property type="nucleotide sequence ID" value="XM_010705260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SLS1"/>
    <dbReference type="GeneID" id="22579661"/>
    <dbReference type="KEGG" id="lpan:LPMP_356330"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350071800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_356330"/>
    <dbReference type="eggNOG" id="ENOG502SJDP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23244:SF498">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23244">
        <property type="entry name" value="KELCH REPEAT DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="484" mass="52223" checksum="45EB7A6BDBA632A8" modified="2014-11-26" version="1">MTQSFNSVSEFPYAEAATGSAKRTSLIQQGALPPWTTSTVESTTVCTKDKVFAIGGFDVYKQRTVSHARMWDSGTRVWTRMPDAPFRVAHASAAAVPGEGSVVLFGGWEDEKCSAELWYLHPRRPGSTAVGVGEVSPPGRGEAAGGDPTPAQASARGRPSKGDGEAALQWDRLEADTRVSSRPVGRHGHALASGVSSPKARWQTSPPSPPAAESLQLSDESLTPGAATVLSGVPTVTGVEPVLYLFGGSDTASLLNDVWRLWLAPSIQRRVAYWERLEVARGVSPCPREDAVLAFDASRQSLWLYGGRTATGILDDIWYLSLTGESSSSGLTWTPVQVLGGHPLGPTRRNLSKWCMPAAAAVEDGSLYVLFSDTSMSAKRLYSNGGVPLYRFCLTTHQWLSFSFSEEEAASSRSSNSQQALLTLAQHANSFRFVASCACNRFLFWLKESADDEAINSHSTPTVVHVELNVPATKTTKRRTDRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4W6</accession>
    <name>A0AC62A4W6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3520230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="XUY36855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="267" mass="29377" checksum="81DCF79934054BDB" modified="2026-01-28" version="1">MYMRRIHTVAPQGVVNKIESTAKARKETMPRLCVEYSKSGRAKCSNTSCGKKIEKHELRIGTEVIMQFRDEEIESWKWRHLCCFTERQLSNAKETGDINAIQGEDDLAPADKALLQEMREGRLVGDTSILGRIGDVTHSPVADELKGKGGKVAKSKAKASLSADNRGSPSATAGEKRPRLPLRKANMTNATTKDDDADSEATDEYEVAVETVTGNLKCPYGANCFRTNQEHFRQYTHGDENGTAADAAVPSDHSGAKLKPVIKRKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4Z5</accession>
    <name>A0AC62A4Z5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase M20/M25/M40, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3320400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="XUY36748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="472" mass="51182" checksum="D9528480A5A26E51" modified="2026-01-28" version="1">MGDCDWTVIQKAVGAEWDASIIPALSAYIEVPNQSPDFDPHWATNGLMEKAFHILIDWVKGQNLLGLSYEFMEVEGRTPFLLVEIAGTERTNNTVLMYGHMDKQPPLRPWAEGLDPHKAVMRDGKLYGRGAADDGYAIFSAITSVSVLQRHGIPHGRVVVVIEACEESGSFDLDYYMAQCKERIGNVDLMVCLDSGSLNYDQLWLTTSLRGVTGGVLNVQTLTEAMHSGVAGGVVPDTFRIARELLDRVEDSKTGTVLLPEAHCEIPDHVAKSMVSMKSVPFKQQFAMADGVSAEPGDNVELALRNFWKPSLTVTGANLPEPQIAGNVIRTLTSLKLSLRLPPLVDSGKATQAMAKLLTTNPPYGAKVWFEPEVPGDGCATPELKPWLSNALNEGSKMAYGNPLAYQGMGGAIPFISTLTKMYPQAQFIVTGVLGPKSNAHGPNEFLHVGYAKGLTLAISHVVAAHFLLAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4Z7</accession>
    <name>A0AC62A4Z7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_311700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="XUY36696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="585" mass="63513" checksum="6A303CA54A27FC81" modified="2026-01-28" version="1">MSNHASMSNGETHRPHSPVHYSQEHTHHAQNKAQQPSHSQPRRTGCLGVLQCIRDGVIKAVCTIIPPGGILSAAFNMASASIGAGILGLPSATDSAGLILAILYLIVITYFSVFSMYILALAAQNTRIKSFEGMARWLFPAGKYAFSYWAAFIRCFHGFSASVAYVISIGNSITPMFAGAAKQHPDNSAIQFFATTQGNRVFTVIIWLCVMLPLLIPKHVDSLRYASALAVMFIVYFVIMAVVHSIRHGLPETSKHIRLSGNQVDDDKLEHNTVFLFRTGNSVIYTVGIFVFAYVCQVNAYEVFWDFRPEIRTAKNYTLAAFIGMMMCGTLYLLVCVFGYLDFGSKNLLGKSLLLMFNPLDEVDIMIAYVGIMVKLCVAYALLGIAARNSLYYLIGFQHRYRNRPAAAVAGAAEELGAVDGCAAATAQCSANPVVAMTDIAVVQSGGLVGADNNHGPAEATKDRNSSPSLNEDSVDEEYVDNTTEDTTYVDNIPFWQHLLVVLALSVASLLCGLFIPNINTVFGFAGAISGGFIAFVFPALFVMYSGSFTVAQVGWFTYLNTYLLLICGVVGIVFGTAGTIYETI</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5D0</accession>
    <name>A0AC62A5D0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">40S ribosomal protein S4, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1320240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="XUY36995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="273" mass="30638" checksum="FB7447105E4D98B9" modified="2026-01-28" version="1">MAKKHLKRLYAPKDWMLSKLTGVFAPRPRPGPHKLRECLPLLVIIRNRLKYALNAREGEMILRQGLVHVDNHPRRDGKYPAGFMDVIEIPKTGDRFRLLYDVKGRFALVSVSEAEAQIKLMKVVNLYTATGRVPVAVTHDGHRIRYPDPHCSIGDTIVYNVNEKKCVDLIKNRQGKAVIVTGGANRGRIGEIVKVERHPGAFDIAHLKDASGAEFATRAANIFVIGKDLNNLQVTVPKQQGLRMNVIQEREERLIAAEARKTAPARGARKARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5K9</accession>
    <name>A0AC62A5K9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1320020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="XUY36973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="776" mass="83995" checksum="8955A0636EDB567B" modified="2026-01-28" version="1">MKKLFGSRNSANTSSPTPRTTAAAVDSNKRDELYEAAVGDGKGGVLNKDGDMSGSTMTDAASIYTGGRQGLDPAKRHGSCYIGGTNGRCGTCGLSKIACNCQTCHCCGRFLMSPSSRRHCRQCWRATCADCSTSVRTNDFMGGRVTLTCNFCAVPKALCFVTQMRYSSYDAVGAVDLTMGNGAVRNDDVGAKPPQANMRAAMEPCTFRWGVYALGCAIESPRRCINPSCPAPLSYAEVCVRCKMPTVVMTFHDQRHIVMQNTSVEGKRPDANDSSVRMVEAVEDAVRSAYDNMATSRTSADEEEIFASALPSGMETQLFSSALSGPAVRKVLLSLVACYIAGESSGTPCVSLALTDLPLYGRLLRPTNVTELFTVFDGPGRTRFISFSSGTTRRPALHQVLGTRMVPRELWSNATMKKENVVGKVVGGKEAARKGGLNTNVATWTMRAGLLAYMAEDNIMDRVQSLALRIVKSSSEVVICGHGVGGAAAAWLTTCLLLENTPETRDRLMCVTFGAPLIASQSLSEVLVKNDLAKNFHHFVYGSDMVPRLCYVDSLLLSGNTAGCTLSVGLEEEAASGRRVQECTAAWVALHEEPHNPADIAQAMAEIGDDNLSLTNFSSSAQQAPIEGPIDAAPPDKKELSKQPTQPADTAARTAATAMGDLFLQSREPFGNTSVRTVHKGDEDAQGAVVAGHFNVRDADFKYFSSQQHRDRQVMDPFGFYHFLWHPRKKYMCTDDPKTIIAMLSDRTELRIQLSDHLLSSYNKGMLEYMYSACPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6S3</accession>
    <name>A0AC62A6S3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SLACS-associated protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0220230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009371">
        <property type="protein sequence ID" value="XUY37408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1015" mass="110719" checksum="E6492489CCB0FFC4" modified="2026-01-28" version="1">MYPDTAEQEEEDTGSAPRSAEPRTETHTPPTQPPGTEGEGEENDTAESANTEPDQTVEDVSQTSDEARHRFHHGENTAAQQTGTIHCPVCPRTWTSRARRQQQTSHLNTTHAREVVRVDALKATGVDRCLSCGEFVIASGNARRAHGQKCGEFVTRAVRNQKRARTEQSTPRQDAVAEPTPETPPPPTRHRTRPTEADAEWVQEFPATIRTLRKQEWGHWAEAVGHTLLGYTAAAAAGRYQRQLALTELVRTRLAKPRAPAREEDESHQEEPSETPREGGRDEPYTGHAGATRRANTEEHLPTRDAHTAEERRARRILHQLSLGAVGKAARTLFQAQLPRARASEALDQLRTLHPQEDPAGYPCPPQTPFPHGLKPEKVRNVVLKRLGRAAAPGLDGWTRELLVPVVENAALLAETTALMQDILAGNVSASFAFRLRACVVHPFLKEPGSPKVRPITPESVWLKIASHLALDAVEKPFRDIFQGWQFGVWGDAAEAVTQIRETYASESADTLVALDATNAYNRVSRAWVLRAAYRHHALHHTVGVVDLSLGEPGALGVYEGGRRVEQLWSTRGVRQGMVLSPSLRHRRGGDTAADHGGTPARQSDGVSRRPDRRRSTGGGPGVPGRGGASARGHRLRHQSGEKPPPVEERGAGTGVGRRGGGAAGARRGAHPRRRFPRQRRTGGRVGVGENPPVRGVLHRPWRGRAPTTRAHEPPACVGAAAPDLSTADPQHRRATRQRGMVRRPRPPHAVGPRGRRADRRRGRTPCQAPPCHGRMRAAVAAGYLALRGAKRRPERRAEGTHAPTGPTQPRGPQNTPPGACPRDREGQHGARCHARARRPSASPGRLPLRGPRPPAAPPTGSPSRGAVRMRGGRGQRARERMPVGPRGPADPAPQPRPYGHRGVGQTTRVRSGRGAPGEQHERRTARPEHRRGGRDLRHGRGDHVPRPSPQRPAEPPSAGTRREEAEVGRLGGRNRHHVCTGVARVDRGPPQGELPVAAGRRGLRQLPVLHANRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6S9</accession>
    <name>A0AC62A6S9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATG8/AUT7/APG8/PAZ2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0920040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="XUY37321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="124" mass="12846" checksum="4224028B6550883B" modified="2026-01-28" version="1">MSAYVSSTPLEARVARCASLRATNAVPVVVEEAQARGGKAHFSALPRETTAAQLVAAVRAFRGVAANKPVTLTVAGCSVSPSATLGELHDACKQADDGMLYVAYTAERSMGAATWKPCGSCSWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHJ1</accession>
    <name>A0A088RHJ1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_020350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_020008500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_020350"/>
    <dbReference type="eggNOG" id="ENOG502SHIG">
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019073">
        <property type="term" value="P:viral DNA genome packaging"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021304">
        <property type="entry name" value="Adeno_L4-33K/L4-22K"/>
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        <property type="entry name" value="Adeno_L433K_22K"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="39"/>
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            <end position="518"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="EMBL" id="AIN95215.1"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000063063"/>
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    </evidence>
    <sequence length="2853" mass="288829" checksum="7B7AD5596F186D75" modified="2014-11-26" version="1">MSSLAPSSFTGPPTGSFQVLWPPRDDVIAAPLGTVPVDFSSPLPVPLSTRGDEPDSVSRAGTGRSSTFDGPFSPLAMVGVMHRGSTGSGSGVGAGVLRGLLTPAGSFNAAHQQARYPPCQWQARSTSPSAAVRNPPNSSLSSSAAATTASGIASPLSRNPGPSSHGATRLVSSHGIQDDSAAPPRSSRASLRWMVEEPTHTGGREMAGTLAATLGQVNASDGSGDCSASMPPSSAQLTLAATVNSSVPPYTSRVWQASTTPPFQYPPQAPCTGHRADCIGTGGIGGERTASPLPSSVAAGTAALSGAAEGTAPRSCVPVMLPTSSSLSSSSLPMRPPSHAGLLAAAPTAGSLPMTSIKRIATGAGAVGVGNAVACAIPSLCDASVARLRHSDPEVRAAAAELADGQQQPQHCQLQGHIGVAVDVSAVVGSCEGSDGAGNNRSPRQSRPRGLVSASSHAFRACRSQQPSPQLAESGKHVDGEEKGKPARQRLWLSHDDSELSGLGPSSSAPGAFSMDCGRDREAPPFVAARSWSSSLTESSSRSPLAASVAQLHDCHTASTAAALGFSTQTPPIALVTVPSAATSTAPLAPPALPSWKRGKLRRLAAPSLGGAGLVGRKLPPTVSAAASIIQGRSPRTPRSQREAHLMPLMRVALIDARSVRSHLEELRALLPKHRSGPAGATTAQDISGAIAGNSESAEATYRATAAAAVDTGDAQRTGPSGVADVRAGDDDEAEGVDNMLNSSDDPVGIVEWTTAMSPASFSLRQKVLRDKKTDGIGGGGDGGSNILQARASDGKASSQLPCSQGLHWNGSDVDGDGNNDGDGSPAATFNVRGLYTSSLNGYRHQRLTRLTEQHLKSLWLGISVVAKSVCGVAVEDCARMALAQGQAPMDEQALGSPCERGAAMSATPPSPPSTAVTASPTPCDPPKPSSAAVTAQDGEATTAKNASSGASKPLLSEGPPDTTPSFHFSSPALAAAPAERRTLACGEQAPTTATTMRRLGGPMRGNPSSGRHRDTQHRRFDEAALLDSVLAGGNGSAPSSLLGRTAVLAAAVNGSPTVFTGDEEGSRMSFSSSTAAPTSLARRTSASPSTSTALAQCTYSDCYRSGDSNSSSHHHSTTSPTSLSKWRNTSPSGTIYIHNTMTSLSSAETMTSVLDDAPSSSGSRMHNSSSSSSSRGGGGGYAVGTAVSALSGLPRPAIPTTAMTGSGGQSLYTLPSTLLPLPALQQGSLSQLAPSTRIGGAASPNNYRPPPVATVTPLSPPLHQPLAHGGTAPTSAPPTAAPHHSPSSAWYSEVGVDGGAADISSSCPLAAGTSGSMWMLPLPSPVPPPPPVAVHRGTTAAAAASGGGASRVLAVVPTVPSASSTSYGAANSGAGGCASALQRPCARSSGVVPATPFTSPPSATSTPTLLFAMPSPPVKAPFIKVQREEVVADTTPDLDSNARASIVPCAAAVVTAAMSASGTAIHAQDEGCGRAPTSSALPLTGHERPGEIGMEARSGTALPPSSAAAAAVVMVAQDEMSRAPHNVGAAATLPPAIASSHDTQIEGERSDVPPTYGSMELIACERHGSDDIPTPSGAALVMMPDSLLPRQSGADTCTYYSPVLRSSATGTAATSALSADGDNQLEESSESDGADAAGKAPHKLPAHAASEGAARAGKVSREDVIDGAGASSGFSIVYESAASPPSLSQRQSERGAVSAAAHPCVAPARGLSFSYATILASRAEAASAVATTMTVAEACISSSAPSATPPPPPRAELQPRHRDDGRSSPPPMPTSDSALHDLRGGEDADRTVKRSSSSGSSNIVEGSALQTPPQVALPGTPTKDRSLHAVPQWAQLHPPQTPTSTTTSLETRSADSAGVLWMQTGDEEEVNAMSALACATSLPVHPSSSATDERESCPPPSLPTLTELIHTEVVHSTPATEAELREGATLAKQFKGEESAADTPSSMVPFPTLQSWAAHVGRHAGLCISSAAAALDVEQSEALTTSLQLSGSVCMPAYADRYTGEDCGGASEAKEAKGDVAPDEATARDSEDGRDLLSFYVNIDAHDLPSPSQSASARHQALQQHQHHQHQLMQTWSSILTISSSGHSAATASSLRTTLTSVTLSASMAALGSRLNTSSTMTSGSSTALPSVAETILGISVAAGGGGDVGAACDTDFDAPCLSTTFNSTFTSTARTQHVLSRLKPLPHFSPPQNYPFPLLGVSSPYVLDYRGFEEDGDDVDTDSYTQDTDDTDLLGADPEFEDEGRHRTETPVCGEASGGGSAYDDSGVEDRGAVAKSAASPSQCHEDGKDGVEASPTQPLPESSTSEAKPFTTLAGSTAVAVAGASGQCGAAAPTRHDRSSRGGRSGVSSHAIRTAALESQALPAAPFPEGASLLTATADDGGARGASAYAVVTSRAALVQASRAIEEDKDEDDNTTEDGTSSAHLSMRSLGVPMAQLPAPVGADSTTTAADTVTTLVGKGEANTILEGRGDPLGMDKGIQMAAAMTPSAQAACDVESSELEDAASVVMVKVTREPTEEAPTVGAVTFLVATAAAAPIALLQTSPPSPSSSSSDAHATPVRCSHESQSRCPPPALLVSAPIDRVRVDTAALSPSAGKEKLKKRHDGDRRAADASAVLSGASLETGGALLITSTPLAVTTALRATGASGSDGLIPCLPLEAASSAAPARAPSTILLEPRERPSPPLPQTRFSLPSYYLAQCEDGLADVAGSLHRWHAETSAFFPETESASTPCRTHGRRNGSSGGPAHLYLSISALARRRAQQRAFYNSAGLSGSAALPPMKATAVDMLSSASAMPVLPSRVSATPDDTEKAATSPTLSSAAAGATHNDRLLGSMVRALWLTGGGDHGGGAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHU1</accession>
    <name>A0A088RHU1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
            <ecNumber evidence="4">4.2.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LPMP_050270</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:45812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="EC" id="4.2.1.134"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.134" evidence="4"/>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="AIN95468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703790.1">
        <property type="nucleotide sequence ID" value="XM_010705488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHU1"/>
    <dbReference type="GeneID" id="22572105"/>
    <dbReference type="KEGG" id="lpan:LPMP_050270"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_050007300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_050270"/>
    <dbReference type="eggNOG" id="KOG3187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="46988at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102158">
        <property type="term" value="F:very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007482">
        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035:SF3">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AIN95468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="224" mass="24891" checksum="5FACEE3494E1C487" modified="2014-11-26" version="1">MGIRDMYLLAYNASMCVGWGAILVKVVKHFVDGGDAASVYPEIAQLLCVAQTGALAEILHAALGVVRSPVGTTLLQVLSRLIVLYGAVRLGDTEATRGLAFVQMVVAWCLSEVIRYSFYGANLLNATAPPLTWLRYSAFMVLYPVGITGEIGCLYKALPYIKKHKPWTVEMPNKLNFTFSWYNSVWFILLGVYPYGSYVMYSYMLAQRRKMFAKAASERAKKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RI48</accession>
    <name>A0A088RI48_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_050240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="AIN95465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703787.1">
        <property type="nucleotide sequence ID" value="XM_010705485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RI48"/>
    <dbReference type="GeneID" id="22572102"/>
    <dbReference type="KEGG" id="lpan:LPMP_050240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000024700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_050240"/>
    <dbReference type="eggNOG" id="ENOG502SPVE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277778at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="129" mass="14626" checksum="817D3AF29B3B19CE" modified="2014-11-26" version="1">MHARLSRVHPISSQSSPDCPKVRCASASSNSLMPRAYYKPFTAYEEAFGFHATRRNAYIMCSVLFGGLLLKCMLLMKYSSIATPSWTSPLEDDPRYQEMMERRLALAEDLSTQESMKRAIRTRRSAPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIC4</accession>
    <name>A0A088RIC4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Double-strand-break repair protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_051090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="AIN95550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703872.1">
        <property type="nucleotide sequence ID" value="XM_010705570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIC4"/>
    <dbReference type="GeneID" id="22572187"/>
    <dbReference type="KEGG" id="lpan:LPMP_051090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_050015000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_051090"/>
    <dbReference type="eggNOG" id="KOG1213">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10071381at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039781">
        <property type="entry name" value="Rad21/Rec8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006909">
        <property type="entry name" value="Rad21/Rec8_C_eu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585:SF69">
        <property type="entry name" value="FI11703P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585">
        <property type="entry name" value="SCC1 / RAD21 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04824">
        <property type="entry name" value="Rad21_Rec8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04825">
        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Rad21/Rec8-like protein C-terminal eukaryotic" evidence="5">
        <location>
            <begin position="518"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="452"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="470"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN95550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="572" mass="60489" checksum="AE41C84C124C9E4E" modified="2014-11-26" version="1">MFFSTYVLTKKGPLAKVWLAAHWDKRLTRHEVKVVDLSQTILHIVRPVVPIALRTSGELLVGVVRIYALKVKHLLKEATEATLFLRVTTLATKGSKAGLAGQHRTTSIDGAVVPVKGSDVEAVTFDWNADIAAKHGAVADVAEALGEGRFSAIADLLGSGRRIDVADTDKEEALLASAWYTVHPLSQAAGDELHTTQQDYDEIAKMRADLMAFGERASGSASTSKSKSSLSSMEKGRGSVAAGVNDIAFPTVGDELDIGVPLPDELPAGFPALDGQAPSGMMPTDPFLLPDMITMNEEAAAAQQAGPGRKVRPVNVCDLASTTLSREAFEKCMADRSDILNSGLRRGPHDAQEEADRYTVTRSSNLANTVATNLLIDAAPLSGVLSPALRLAYAAALQPSVEEAATMTARALRTSTAQRSEVPAGGGGALEAEDAQVAAADLDGSAMLLPEEVTQQPRKRGRYDGDGVDDSTTAAGVSTSAQQTLERIRTELSLRAAHGRKKSRVESTASLVGASCLLREVCHGLRRRDAARTFVDVLALASKQYVSAQQGPGSDEVQVTLNELALRLLAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIN8</accession>
    <name>A0A088RIN8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_080430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="AIN95852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704174.1">
        <property type="nucleotide sequence ID" value="XM_010705872.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22572505"/>
    <dbReference type="KEGG" id="lpan:LPMP_080430"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_080009300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_080430"/>
    <dbReference type="eggNOG" id="ENOG502QW44">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273509at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="609"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="659"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="764"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1099"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1408"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1500"/>
            <end position="1520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1535"/>
            <end position="1565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1890"/>
            <end position="1987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="509"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="699"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1416"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1538"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1948"/>
            <end position="1958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1959"/>
            <end position="1976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1977"/>
            <end position="1987"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1987" mass="214002" checksum="3CDC27644E677B03" modified="2014-11-26" version="1">MYKLHKRIDASPRVDGDISSGGADVHCANDGREYEQPLTGPQSIPEDGVRDAQQLYHSGQRGYEYGHSAESGAGAGAEGPDDPVAGSAEGYRDYGPEDSGAYGVASYFGQGSSTQQQQQQVGMLAPQGYAQGGETQGDGEDEAHMFADYRGPIDGERAERYNRRLQQQKQYDDIPTPPDDADPREVFAYYRKLIGLVHFVPPRHWREIRFDLPANVAELRLYPQRRERVQDREPIRPTSCIAISLKGMLPENTTPSEYAAQMVQYMFDLLNYQNASTAITELRFVKKGTELLQMVVTLGKDTRLAGRVLTELQAAGLRAYYGKPVFEFPPNATFQVIDYRRTLHDGRGISADDVTYLLEPIRQYNTVDINVIEGYEPGVFYAPVKRPETVYSFLWNYFCSYKFQSDLFRRYGVLVTMAQCPHEFLQKGIPYHIQKQQLEEKIRAELQRKGMAKREHDGSGGGADAGGVDDDSDDGMNGGVDEGTGEGPPPAWAANAADEIDIFSSSPRASHAQQQHSTSAAASDSLGYGSASSRAAATATAAATANTVATAITFVDEDGLEDVDALLRQYNAVTEPTPSAVKAKDAAVKGRKAKEAAMEASTATVGGCGVGEEVSAPPDPGSQNGPYIPPPPSVAGAGWGGGHSGYGREPYGTLPGYTPEAGTYGYPQPPQYYQSSLSYGGGGRDAQPDSYYGGHHGAAPPPHVNPPPNVAQRHSASYAAPPYAYIDRSTHSTAADALAATATASGGAPSAYPLLVDEVDDEQGVIPHSQQQQQQQQASISWTGDGFGGDYGELDRQQQRPPSSFEATAPASHEKDMLLSWSMDEGLANSTASGYATTGFFSAPPPPHSQYVPGNAFGQEDSEGGSAMQSHGSNWPVFSDAPQQQQLLLNTYESGALVGGVLGDCDTTLPPYYSGSDGSGYLQQPPHAAAPWGYADSGSGAPMRYGEPMPMPMPPHVREAAEIVADLEERIRAAFPATWTTAFDASAQPFLLDGEALAGQEMQSTLEESSCVLEHLPDAAAAAVANLPAPTTEIEELLSFLHRNVSLVGRLLHKTTTTTVEQAAEVAVFRARVARALLIGATMTIGASESPASPEAVRAAWEQRSADGSAMPAPPTPAHHNKGGVSADAEEAAAETQLPALLPYLLRTPSGVDLAMLLAFHYPQAFSRRFLPYAPAYLFDENVVRVVITTALRRDAQADNVLVRHVLAHWFPLAQWLLRVAHHKAAAKRDGGGASAPVAGVEESGRRTVAMKHLVSSIGSTMDAVLAALSTVQREACRASSDACDYVTAFAEAVCSADAHDQAGDGGALPLLWGPDGALYRSLVRLYVNADVCDGAKVALHMLCCGRSASSPTLTSLTNSEVCLTRDHYYYCAVLLSRSHTAPVLGRETAAFCGTFLKLLELQHTRWQQQRRQETESGGNTTKTPSAGEAEAEQLLDTALKAMETIDVYTALRDAYLAVEVPITRFEAVLARLSPAEPSAALQLQVPTLEEWYDGSNSCRGRGDHNAGHPPRKRGAEAPAIPSIFYYRPPARRDARWTQLQQQQPQASRVASKAPGPGGANGQTSIASRWRQEWTAAMRTYPPSGVPFTALPEGWTSQPSRECGHYYFKPPVPASSTDGAAAVDAAVSATAPTYKHPVDGKEHLVTPQALLLQEAAADVSTPSATLDQVRTRANAMHAEEAAAIGLPPPAELTAADAEAWASDQRRRNVFLDIATVELLDVKYRVAGRPGPVTVEAASASGVKRGRDAGAAALTSEQLHQLLHKAIPNSYPPVGMPYPALSRGWSVYLNSARGQYGFKCPSSGSSQPPLFVHPKTRKHYFVSPQAFVQQRKVNLEVVARDAGVEKKDVESWMTDQRTRHAAIDAAVVKLIPITYSDVDKVMEKSAAVVEAAEEKAASPPASTSRDRDHQHQPSSSSRHRLEREGRGSSGGRRRRRREESGSNASYSDDGNHDNHGDSRSRRRRRRRRRDRSPRRRGGNSGGGDVRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJD5</accession>
    <name>A0A088RJD5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amastin-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_100230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696745.1">
        <property type="nucleotide sequence ID" value="XM_010698443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJD5"/>
    <dbReference type="GeneID" id="22572759"/>
    <dbReference type="KEGG" id="lpan:LPMP_100230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100007500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_100230"/>
    <dbReference type="eggNOG" id="ENOG502SFS5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="258050at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009944">
        <property type="entry name" value="Amastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297:SF4">
        <property type="entry name" value="AMASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297">
        <property type="entry name" value="AMASTIN-LIKE SURFACE PROTEIN-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07344">
        <property type="entry name" value="Amastin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="303"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="418" mass="46297" checksum="B00CCD35CD2BA288" modified="2014-11-26" version="1">MSGKFQRESLNGSEMGNKQPSGQGKPDDTNASLAFLRTDEKALEEAPGVDLRAVPTENSGRKVMIAWIIFSLGSFGFMLVASCPVPWLRDRQGGKWTLWRDVNGTPWRMIECDHRRQMFQAMEAFTILGCLLSLASLLAGILQIKDRGHLGVTILLGSLTVLVVLADWALLVNEYYKYSCLGQIAYAAGVNRLNAGFLLVLFSFLLMLFGVITLGRWMNTTFSLSEVQCAKYSSPALTSAFISGCVLMIATVGTTQTMWVHYDTTISLKINYWHIEIYHRNVSLSEIWPLSSYHCTQFTLRMLISATFSIISDVLLLFTFLFTVAAVYKHPCKWIAVVLGVISWVFLLVCWAIAISVRHTTLCTSGVVPPSTAIYGAPLDTVEQQVSFKGFVITDGLGMIISAWCFTTANVIYLAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJU9</accession>
    <name>A0A088RJU9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_110770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696925.1">
        <property type="nucleotide sequence ID" value="XM_010698623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJU9"/>
    <dbReference type="GeneID" id="22572942"/>
    <dbReference type="KEGG" id="lpan:LPMP_110770"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_110011300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_110770"/>
    <dbReference type="eggNOG" id="ENOG502S7NZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277516at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="21129" checksum="2E0D27E9BD1B1200" modified="2014-11-26" version="1">MAAADQLRYAAQLIELARSEETEDGNPLTAVRYYTTAMEIIASEASNLAASITRNEARRFFLFQVRSKLDMYYQRAELLLQVASGSGLLDKPSIGNGDTPPFQVSYPPALYTPAVASDKSNSGDGAGGGGSVLGIPLLPQQMMPTASPPQTQSGHGNSNELPISLYLKPDDDGTAAPPPVTSELDLDKLMKNLGAPPDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJY2</accession>
    <name>A0A088RJY2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_101240</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Sodium-phosphate symporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696846.1">
        <property type="nucleotide sequence ID" value="XM_010698544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJY2"/>
    <dbReference type="GeneID" id="22572861"/>
    <dbReference type="KEGG" id="lpan:LPMP_101240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100019700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_101240"/>
    <dbReference type="eggNOG" id="KOG2493">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="259826at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF96">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="261"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="261"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN96193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="493" mass="52415" checksum="8D050B68C047E48E" modified="2014-11-26" version="1">MADVNPYLWIVIVGSFVSFLTGAGVGMNDLANAFGTTYGARILTLTQIVIVASICEFSGAVTLGGEVTSTISSGVADPKDFAKQPYVFMYGMLCACGAAFCWLAIATWLRLPVSSTHSICGGVIGFALVYGGGGSVNWAKKKSEFPFFSGVAPIVASWFISPVLTGVVSALIYGLVRFLVLRPKNCVRRAMYTLPIVVAIAFFLESFFVLFKGASKRLKWSVDRAAWVAACIGAGAGVLSCAFIPLLKRLVARDEARALAASEERPSTTEDSNQREPLSVEDVRKPREVTGDVVNESEASDSERSEERKVTGASGLQVQQYEWGAERVFRYLQIFTAICASFAHGASDVSNAVGPLAAIYQVYQSGSVEKSSSVPIWVLCLGGAGLVLGLSTFGIRLMRLMGEDLTVITPSRGFAAELSAALVVSFASGYGIPVSSTHCITGGVIAVSIVDVGFMNIRWIMVLKMYGGWVFTLVITAVISAMFFAQGVSAPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJZ0</accession>
    <name>A0A088RJZ0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_111280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696975.1">
        <property type="nucleotide sequence ID" value="XM_010698673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJZ0"/>
    <dbReference type="GeneID" id="22572993"/>
    <dbReference type="KEGG" id="lpan:LPMP_111280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_110017200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_111280"/>
    <dbReference type="eggNOG" id="ENOG502RJTS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:001014">
        <property type="entry name" value="Nodulin-like, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010658">
        <property type="entry name" value="Nodulin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF158">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 12-LIKE CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06813">
        <property type="entry name" value="Nodulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="460"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="495"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="519"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="553"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="595"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="Nodulin-like" evidence="6">
        <location>
            <begin position="27"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN96322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="626" mass="68215" checksum="AEF33E326434DED9" modified="2014-11-26" version="1">MANGETGLLPGRTYRVGLFEYTLEKAWFCQFCIGILICVNNGACFSFAILSPYLKGEGFRYSQFQIDAVSTVGVFLSYFSMPTGFLYDYKGPTAILLVGTLLNTTGWAGMYLIFTNVLTHSPVVMAIFFGLSQFSASFYETGSVLTNLKSFSCYKGRVILIQKTFMGLGSSLVAQLYVAFFEKASESLAPFFIFLLLYSTFTGLLGILYVHFPTPDTECVGINVEDADTIARGGGEPRMFAFPFNIGTGILCCSVTFVLLTSLVENYVNPLSTAVRVSIGVITICLTASFISMIFTTPNYEVNRRRGAGDEGMGDANDRLSAFGPSIGSSSKAADKMSIGASMDNEDGRRSGDRDDLSRCVVLPAEVELTVLRKDELTSPEMCYKDVPTLPQAELGVACGDTQEGYTVLNDKSLWENVKHIELWLLWFVCFGAWSAMTVVSTNSSHIYQAMSHGSFSLTINSVFVSIYGVASALGRILVGALYPQLARRQVSESLMLLVAPILNIIGLPLFLICPARFLFVPFFVVGLAVGFSWGCTVLIATSIFTSNSGKHYSFLYTAGMISPFIFNMALFGPIYDNYGAKQGHRNDGTCDGAICIAVPLIVCMVVNILGVPSAYVFYKLTKAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKC4</accession>
    <name>A0A088RKC4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_130480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697130.1">
        <property type="nucleotide sequence ID" value="XM_010698828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKC4"/>
    <dbReference type="GeneID" id="22573158"/>
    <dbReference type="KEGG" id="lpan:LPMP_130480"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130008900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_130480"/>
    <dbReference type="eggNOG" id="ENOG502S2PT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271172at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN96477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="325" mass="35302" checksum="0D47A3BA7465FD72" modified="2014-11-26" version="1">MDVLNLISLVVDLRDYPGYATCTRATEYPGLALCEYSAATGMRYTVPLGYAASVVYFYFYHRPRLSFADRSLTKLHHYFYPSAGYSAPLGIIGGVLYGAGECAQGLTPAALEATAAREKAAALMAAEQYSQRHRAAKRRLKAEQSFLSKALVLLRLREDPVQAELARMGLGEDIIAWETLLVPQGYLWTQLHSTVHDIARYRDYGTPVVAGAAVLTSADGRVGEPSDAAHTPCSSSFTFLSPSRVYFTKPQVDAVVSRIGTLRVSPEDDRWMRSAGRCGAYGVLGMLLTWNSGGALFRAQMGLGLGVTIGGLASATRLDQIFTHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKN3</accession>
    <name>A0A088RKN3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial calcium uptake 1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_070130</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009376">
        <property type="protein sequence ID" value="AIN95699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704021.1">
        <property type="nucleotide sequence ID" value="XM_010705719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKN3"/>
    <dbReference type="GeneID" id="22572348"/>
    <dbReference type="KEGG" id="lpan:LPMP_070130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_070006100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_070130"/>
    <dbReference type="eggNOG" id="KOG2643">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="186625at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990246">
        <property type="term" value="C:uniplex complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036444">
        <property type="term" value="P:calcium import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039800">
        <property type="entry name" value="MICU1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12294">
        <property type="entry name" value="EF HAND DOMAIN FAMILY A1,A2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12294:SF14">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001838996" evidence="9">
        <location>
            <begin position="23"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="80"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="118"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="297"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN95699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="361" mass="40904" checksum="444156EE19331109" modified="2014-11-26" version="1">MLAGWCVGVALCIAAGTTVVLCRSYDTPPYLIPYYLRDVRSRFLHYASVRKRKGGPMYMTVEDFVLALLASPEKVLPNPAIVQDLQRLFESMDANGDGYISFPEFRFLMSLLTSNPRDVETLFRIVDTDKSGTLSLEEFANVLRGATKDEAVVRSLLKPSTRRNGVVRALFGDEAAPRKCSLSELEAVIRSVRTEVWKAEFRQYDVEQHDCITAEEFAALIARQVLGSHLPYYLVENIRCLHGSGDVVTLNMWLGLNEAMLYADQLAAHVEMFLSSGMPVTKRDFHRLMSMTEVSALPNTTVDIIFALFDKNGDGSMEIDEFLFIMRKKVRYHYSVPPRMRKSLPRRFLECSSELLTDLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKU0</accession>
    <name>A0A088RKU0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_140410</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DZIP C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697275.1">
        <property type="nucleotide sequence ID" value="XM_010698973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKU0"/>
    <dbReference type="GeneID" id="22573308"/>
    <dbReference type="KEGG" id="lpan:LPMP_140410"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140009300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_140410"/>
    <dbReference type="eggNOG" id="ENOG502QRAI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="515971at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032714">
        <property type="entry name" value="DZIP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051241">
        <property type="entry name" value="DZIP_RILPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21502:SF9">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21502">
        <property type="entry name" value="ZINC FINGER PROTEIN DZIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13815">
        <property type="entry name" value="Dzip-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="158"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="174"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="270"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="382"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="422"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="564"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="696"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="817"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="309"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="443"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="471"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="504"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="519"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="594"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="709"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="722"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="736"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="752"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="820"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN96622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="839" mass="87169" checksum="2FE7242439DA8523" modified="2014-11-26" version="1">MATTAFQFVQGNERLDWGILVSIDVERLMKSTNVGTLQRIIENIAFSRVTRDEAALLTPDHILHLFQLCQVVIQYLVYSQEILANINVKLNDRMEGQQATAHEREMLLQRLSDETALLKKQAKTQRRTLLAYEYNVHAALARGVTGSGAAPGVPATLYICPYCGDEYHKAESMQSHLRKRHNTTAGSTNSPVAGTATPPPPPIAGGGGGPTYGNHPESSIPPAAGGCIAAAGDAETLQQLRHRVEQLERDKEVMERQQRENLILMMLGASRSQPTSPPPQQQEQKPASAPSSTSLHPLVSPSLPPPSPLSSATAAPSATTTESALNTIPEHLQGIPVVPDISAMMNYNLSCQREASENALRRQLVSLEAEIRALRASKSSAASTVLSEAPPPPPQSTPGPCITASTGVPAGAWPAWVAELENAQQRQHQQQQQSTTTEAVPSLTPPSTPPPAPLLPPPPQQQQQRDYTTGVTAPSPVSPPSHSQSSSTQPASTSPAAPLIQAMPSLTAQSPLRSSSLAPQPSYGIQQQQQQHPPTVQPSTPSAPGLSTAVIPIPSPTTAAITEAGAPAAPTPTPSVSIPQPLVVHPKPHHRVESSTNSSLTSTSTLPPHRAVSKGPPGISLSHISATPWTLSTLTSTGVLGGAALATAAATSTSVAPIPLPSTTSTGLLAPPVSSPGLGVGSYFSSRTSVPAAATPALLPITPPPAARDSSSPTQQYSYTAPLSTVSPSVSSTHNSPPPPATVPEPSVPHPTSVQPLRMTNTPLSHAPPLPVPVVAGSTSGNTTSVNSWSLPAPVPSIATVPVPAPAAVSGAVKPFRTLSSSSSSSSGSRFGAAGRYEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLN0</accession>
    <name>A0A088RLN0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nucleoside transporter 1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_151160</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697491.1">
        <property type="nucleotide sequence ID" value="XM_010699189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLN0"/>
    <dbReference type="GeneID" id="22573536"/>
    <dbReference type="KEGG" id="lpan:LPMP_151160"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150016900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_151160"/>
    <dbReference type="eggNOG" id="KOG1479">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269989at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034764">
        <property type="entry name" value="ENT1/ENT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00939">
        <property type="entry name" value="2a57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332:SF10">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01733">
        <property type="entry name" value="Nucleoside_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="447"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="246"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="263"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN96838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="478" mass="52481" checksum="DB593A69CB377082" modified="2014-11-26" version="1">MTAGEFYVYVVAFMCGVSMMMPTNAIFSAPGYIMTYYRYAMHDPDAVPRHANFWNNVMTYYNLISLSTSLVIEPLTLLSWFRRIPIKTRLFSGLLILIMEVIVLMVVPVRGTNEAGAVATLCCGGFIGGLGKSIFDLTTYGMFSAFPSSFTSIMMGGVGVSGVLTSLLQIVVKGVLPDTYEGVEKQSKLYYGLDVGIHAATFVALFLLRYNNFAKSHFGDLGSAKSKTGTGSLGIVLHSPYEHLDEEESHKSSASREPATDELQVSSAKSEGSATEQDSLDEYLGGARKDRWPSEGGRPKSNEMLVATAIVSTLCCIKWMFVACGFDFLITMFLFPSIAVSAFPNSKWFATIAVLIFNVFDMLGRFSPSLKFMWPRSRKQHWIIVAASFARVIFVPLLLLHSYHYIPGEAYGYVMQVILGFSNGYVVSMALVLGPQSKGIDNDGKRFVAGTLMGISILVGGVIGTLLSIMTQTIRERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RM73</accession>
    <name>A0A088RM73_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_111050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696952.1">
        <property type="nucleotide sequence ID" value="XM_010698650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RM73"/>
    <dbReference type="GeneID" id="22572970"/>
    <dbReference type="KEGG" id="lpan:LPMP_111050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_110014300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_111050"/>
    <dbReference type="eggNOG" id="ENOG502SEJ2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266877at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="665"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="665"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="797" mass="85934" checksum="EDE236986A0A0D5B" modified="2014-11-26" version="1">MRLAQLSSPFDAVNLHHPSLASPRQGISLPRSRHSGDAGGDDPPFAGDTAGSLPSTSTSTLYSGALLQSCQALLSTQSLGSTVLMERHSFSDWCATAALDDPSSGSCPSSCSWSPLNQTQPRSAVRATATSPISPVGTITTTLFIDGLPASIENKWQLQPCVPPQGLMALRVKSSRGRNVGFAVYDSIAAAHGALTWFNQMRIIKEVVLTSTFGAPPAVGSAPSTGAPPGLVSDDPCVPSGGVTSACFTNSPVESEPLPLKYEDYLCTQQLPGEFASLLRKCTLLRVDWARCLEIQHTPVKVVGAAAPPPSSLVSSPLSHPPSPWRMGAVAVRPPPPPPMPTSVPHVSPYPRGDNDGCFMSEPARHALLLRAPPQQHPPPPPSSSPPIVLSPRFQLPLQPPHPCAPAGWSDAQATHPLEPHPLAQTTLYHGPSPVTHRTWATSAPSSFLQRTELRSSCGSGTATPAYYQPENPTTWQPLGAHLSSHVAERNDQHERVDDWRGVPPKLPGSSYRYEERHPQQRHMAHHHHQPAREPPLPSRTLFVRLIHNFEEPQCLQHDQLRSTTGGGTDSATAVPINPSFATVGPRSTTSGTMAMPDAAAACAEVVALPAPTRARSQTTPSFRVSTSTAVSLSGAAGIHPLVSVVPHHHHCMLYQSPALPTLMTTPQLRSPQDSHTAQAYSPLRPPVSSQLTSPRDDRHSSSAGAADEAVLQPAPNAEDLEFFRFAQSVLRKEYFSERFAGFVRYREFLRPPYYGGCFVLFERGEDMQRCLQWMRKDERLMKLFAVSPARNDSFGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMR2</accession>
    <name>A0A088RMR2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytidylyltransferase, putative</fullName>
            <ecNumber evidence="2">2.7.7.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_171300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.18" evidence="2"/>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697821.1">
        <property type="nucleotide sequence ID" value="XM_010699519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMR2"/>
    <dbReference type="GeneID" id="22573873"/>
    <dbReference type="KEGG" id="lpan:LPMP_171300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170019200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_171300"/>
    <dbReference type="eggNOG" id="KOG3199">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="422187at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051182">
        <property type="entry name" value="Euk_NMN_adenylyltrnsfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039:SF0">
        <property type="entry name" value="NICOTINAMIDE-NUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="1">
        <location>
            <begin position="48"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="307" mass="33638" checksum="B8C6C07BC12B1603" modified="2014-11-26" version="1">MLSSTAAPYALRTDKLKPLEGCAASCPTSTAEAASQVTPLLQPVVLVICGSFNPIHNAHLKLYDAAKRSIEGVDGRVVLGGFLSPVGDAYGKPGLRCAADRVQVMEKALCHHPDLNVDTWECQQPTYTRTFFVLRALEEHVNAWYAQSEPAAMEWLTSHGRHVRVVFACGADLFFSFWRPGCWSLCLLRQLLDSFPLVVVQRGGARGSISDSDDFARVCQTAPLLWETAEDGERIEIDMLRYTFTFAAFSAPDDTSSTAVRNAVMELAKTPVDEVTARTALQSRLRTMLPEAAIQLVVDLYGEGLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNN8</accession>
    <name>A0A088RNN8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_201730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698374.1">
        <property type="nucleotide sequence ID" value="XM_010700072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNN8"/>
    <dbReference type="GeneID" id="22574382"/>
    <dbReference type="KEGG" id="lpan:LPMP_201730"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200022600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201730"/>
    <dbReference type="eggNOG" id="ENOG502SAVQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272254at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="309" mass="32504" checksum="5FF50D5853F6F907" modified="2014-11-26" version="1">MSDTLLAPSRAKVHHKCAVYLGSSTFVELDDDPSTITLEDLCEAFGTPWESGMHVRHRATGRVVATLPFEPMPSLDDVSDVTIKAEVIAATAGTGDTTLPTFSGNAEEEDADAAEEGETTYAVIYDLVTPTAPGDGEDSELAAAVAAAGLSENLSADADGAPSIGETMRQLVELGAAELLTAQPLSVSQARREYNPPDAPGLLRRIVYPASQYSPYRLDRDPLSEDKLSLCQSSAVATGAASGSSPLTCAGSHALPMHDLGEGGPYTSYLDSYSLTCPIAMSFVESPVTDKRAVVIPLSDDEHHRIFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RP91</accession>
    <name>A0A088RP91_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleotide cyclase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_201310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698332.1">
        <property type="nucleotide sequence ID" value="XM_010700030.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22574340"/>
    <dbReference type="KEGG" id="lpan:LPMP_201310"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200018200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201310"/>
    <dbReference type="eggNOG" id="ENOG502QWRW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2021138at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1169"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1302"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1428"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1571"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="89"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1175"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1310"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1438"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1453"/>
            <end position="1469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1590" mass="175134" checksum="4B4A0F2105856303" modified="2014-11-26" version="1">MEGLAVLFDTPLDACMKEKDAHLTNLILEKREAAKRIEGLEAEIAVLRAQLQQATPQRLFSYGSEPLPTSAQEKTAQNNTPIAEILMWNEELINTVEQLQRSLIQLEADSKAQLITVTDVLNQARKENERLLRENDSLKARVGDDVLRQRQTNRMEVACERARIAARVRAAGLQRLEAAEANLMEAHDDVYHVQRWDAMLLPQRDVSFVFHIVSSVTYPLHGITEFIMMVYQQFLFHRSTGLRGYRVGFYQNIEVFAFQAPSDALLFSKECHEQLMRLSWLSCIENTPSFSTILENNTVLYKGPRIHTCICSCSPESYVDPVSGKYAFFGPEVEEAVKAAIEQSPIGEIAVNERWAQLMCLQSQIRENRSAPAASSVAELRECLGSMWDIVDFPGAHHIIASILPSELRSRRGVPAPVLHPSCKYPCLELNDSAFVVRMVVKAMRGMLCNAFESLEEVGDDSNGGGGVILQQMRRRATFLHKAVAKAPLATSAQERNPEFSERAAQLLELFLVREERNNIMALCRKMEAASAALERDRMESEDRFEIRKHKTLNPSETAYICTIDTGDDTLWKRLLLKSISDEQFESIQNTIRGDVHNAAKVHFGFFMNGNDSDVFTYVFREVEQALAFVSDIYIKVNRTGTKYAHTSLGKGRDIFLFRAGVASGPMGAIYRNVENGVLKCTGPAIRLSGTLCDLAECGEILAMEDVIRSFHSKNENLLDTQYNIVNQKSQFIGSYAAPAAVHSILPKPFAYRRPQLRTFGRTAMQNKRLYLPYRSVLGTLMRRRDELPRQAVLDMMEQQQRRLELSEMARMSAEDDYERPWKVGTVAAPLLRNPWLLLDQPQAEEQSENASVRRSFVRFRTVEEVEAEVMHARRPTKPLAFLYCDVAGARTIARSVAPPLLKLVWAHYNYIVQNAVLNFSGYVAKTNSTTAYLVVFEGPLRALEAARQIQLEMVKSIWPEELRLLETTLHVKDPKSHTVLFNGPRPQIAVHLSDQYVWRLISCPPSPVARKNDASSKGACDGGGDGGRTTAASWIPVHISGVGVDETFVLGRHAHGGEIRLSRPLLEAAATHPRGKLLLEQLRMEVVVAPGVICPTEGATKDSRTATGSAKKVQSESELKTVKANIFTGECVVSVPCQLEGRLALILPSASATFSAAKLTKEALAMATTSASEDNAEGPSGEEDVADPVDDTEKLESAAAMSLATETTGHTSTMLPRAILLPEEMVAQHAWFVEPKKSFHPLPAAWRTDWSTVVQQPTNQLAELDFWKEARRIQAALQELLKMFPSGPLLSRALEDVPDDAASEFPTELVTSSSTNPPASGAAGKKTSAENRLPTKIPAPPTSLSAARGSANHTRRLKGTEPSKTSAASTAARTATPAAAVSQYVHFMDFSKHLLTALLNALEIGVDQHSQTSLSILRGGQKSKIKTVGLPPMSGKSGRASVIGGSAGSSSQKYSRSTVNGQIHSSSLGPIEYSPSGSLRESSISLSGISPLSGRPLNSNPAEACVSLTSPSLSRDAELQVMSTSDSRHEDVQVSSERPFLIALDYLDDACRTLTQLSGTELGKLVPIPAAPSSKSKTFPGRFSNARHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPM7</accession>
    <name>A0A088RPM7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">RNA cytidine acetyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">18S rRNA cytosine acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LPMP_171210</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in 18S rRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51424"/>
            <dbReference type="Rhea" id="RHEA-COMP:13575"/>
            <dbReference type="Rhea" id="RHEA-COMP:13576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a cytidine in tRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in tRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53876"/>
            <dbReference type="Rhea" id="RHEA-COMP:13670"/>
            <dbReference type="Rhea" id="RHEA-COMP:13671"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697812.1">
        <property type="nucleotide sequence ID" value="XM_010699510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPM7"/>
    <dbReference type="GeneID" id="22573864"/>
    <dbReference type="KEGG" id="lpan:LPMP_171210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170018400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_171210"/>
    <dbReference type="eggNOG" id="KOG2036">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10067491at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990883">
        <property type="term" value="F:18S rRNA cytidine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051392">
        <property type="term" value="F:tRNA cytidine N4-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904812">
        <property type="term" value="P:rRNA acetylation involved in maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051391">
        <property type="term" value="P:tRNA acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002218">
        <property type="entry name" value="tRNA(Met) cytidine acetyltransferase TmcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03211">
        <property type="entry name" value="RNA_acetyltr_Nat10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033688">
        <property type="entry name" value="NAT10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007807">
        <property type="entry name" value="TcmA/NAT10_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032672">
        <property type="entry name" value="TmcA/NAT10/Kre33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013562">
        <property type="entry name" value="TmcA/NAT10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027992">
        <property type="entry name" value="tRNA_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925">
        <property type="entry name" value="N-ACETYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925:SF5">
        <property type="entry name" value="RNA CYTIDINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13718">
        <property type="entry name" value="GNAT_acetyltr_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05127">
        <property type="entry name" value="NAT10_TcmA_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08351">
        <property type="entry name" value="TmcA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13725">
        <property type="entry name" value="tRNA_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TmcA/NAT10 N-terminal" evidence="13">
        <location>
            <begin position="6"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="TcmA/NAT10 helicase" evidence="12">
        <location>
            <begin position="288"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="14">
        <location>
            <begin position="520"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="Possible tRNA binding" evidence="15">
        <location>
            <begin position="777"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="675"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="964"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="677"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="635"/>
            <end position="637"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="642"/>
            <end position="648"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="744"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF13725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AIN97159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1062" mass="116384" checksum="8DD860A209F2AB12" modified="2014-11-26" version="1">MVKRKVDDRVKTLIDDVAHHKHRGLILLVGDRAKDQVVNLHLMVSRANHNAKVNILWCMRKDPDFGSTGKKQQEKRARLEVKGGLSTEASKEAFQTFLAQTNVRFCKYAETHRILGQTFGMAVLQDFEAISPNTLARTVETVKGGGLVVIMFRAMRSLRQLYTIAMDVHARYRTESKRDVVPRFNERFLLSLADCDAAMCVDDDLNVLPITEKMRTYGKNRKSDAYDADLAVQGRLQHEADLANVKERLRPSEDVGPLVQLCQTVDQAKTVLSLMQTVMEKRLDSTCVVTAGRGRGKSAALGMTVAGAIAQGYSNIMCTAPTPENVQTLFEFAIRGLKELGYRERTDFEALQGVSEEFAKCFIRINVFREHRQTLQFVSATDTAKFAQAEVCVIDEAAALPLPLVKRILGPYLVILSSTVSGYEGTGRSLSMKLVADMRRGSSSGAADARHLKELSMSDPIRYGPGDPVERWLNKLLCLDATMEKAQLTTSPHPSTCELFYVNRDALFSYHPLAEELLQRIQSLLVAAHYKNQPNDLQLLSDAPGHHLFVLCADSVESSAATAPTSSTSAAARQPIPDILCVLHACEEGQVSAQSIKSHLSHGLRPSGDLIPYTLSQYYLEEGFAKLAGLRIVRIAANPALLRAGYGSRALALLHQYYSGSISLTAAEPKVMAAKHRSSDAEADTRGQAGSDHDGESSAATAMLAPRSHITSLLTPLVERPYELVDYLGVSFGLTTELLNFWKKALYIPLYVRQAANELTGEHSCVMVRPMGFDLRPLQHEFQHRLLSLLAMPFRHLPTELALSLVCDLEAHDPHKLSASTDLSEVDHHVVRVDGVVQATSGDIAATFTAGDMRRLRLVSTAFVECGNVLDLVPILAKWYFGKRFFRCPDGTDGVVLSHAQAAVLLAVGLQCQTVEELAAQPAFSAVSTQQLRALFLKALSRLSEHLTTLQKIAKAEQHEGRSVSVREGKCAPSQSGGAAGDSITIGGTAEDVEDAEEIYDSHGNLKGLKVARKVKAQVSVDTTLLRDTSSSVSGNASAACQGRDSLQDVFYRPKKKASRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPT4</accession>
    <name>A0A088RPT4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7">40S ribosomal protein S27-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_180530</name>
        <name evidence="7" type="ORF">LPMP_353860</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697887.1">
        <property type="nucleotide sequence ID" value="XM_010699585.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703321.1">
        <property type="nucleotide sequence ID" value="XM_010705019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPT4"/>
    <dbReference type="GeneID" id="22573943"/>
    <dbReference type="GeneID" id="22579414"/>
    <dbReference type="KEGG" id="lpan:LPMP_180530"/>
    <dbReference type="KEGG" id="lpan:LPMP_353860"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000045900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_180530"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_353860"/>
    <dbReference type="eggNOG" id="KOG1779">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5567124at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.100:FF:000001">
        <property type="entry name" value="40S ribosomal protein S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.100">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00371">
        <property type="entry name" value="Ribosomal_eS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000592">
        <property type="entry name" value="Ribosomal_eS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023407">
        <property type="entry name" value="Ribosomal_eS27_Zn-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11594">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01667">
        <property type="entry name" value="Ribosomal_S27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN97234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO02521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="86" mass="9783" checksum="B58683B952DFAEC6" modified="2014-11-26" version="1">MGFFDADLSYPTVRTERMKHKRRRLVQGPNSYFMDVSCPRCRQVTVVYSHATTAVECKGCSKKLCRPTGGKALLVEGCGYRRKPDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPU7</accession>
    <name>A0A088RPU7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytochrome c oxidase assembly protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_203650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698567.1">
        <property type="nucleotide sequence ID" value="XM_010700265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPU7"/>
    <dbReference type="GeneID" id="22574576"/>
    <dbReference type="KEGG" id="lpan:LPMP_203650"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200042800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_203650"/>
    <dbReference type="eggNOG" id="ENOG502S211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268590at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018793">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_Pet191"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10203">
        <property type="entry name" value="Pet191_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="97" mass="11683" checksum="7BFA4C76D613783D" modified="2014-11-26" version="1">MEKEHKSICWRPKNALIECIVMTKCFQEKESVEDCIATNDCFLERRNWTLCKMNAVNPRYRLRGNPYDLATEDQKKIEARNERIRQRELEEEGLFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPW3</accession>
    <name>A0A088RPW3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_180930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697927.1">
        <property type="nucleotide sequence ID" value="XM_010699625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPW3"/>
    <dbReference type="GeneID" id="22573983"/>
    <dbReference type="KEGG" id="lpan:LPMP_180930"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180012200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_180930"/>
    <dbReference type="eggNOG" id="ENOG502SEXF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266967at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="265"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="764"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="568"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="293"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="893" mass="96345" checksum="825636F2614DA7FE" modified="2014-11-26" version="1">MKSANRSAAGQPAAAPTAAAMATGSLLQEVYFEKQVLKLGMDGSKLPRRVVVTDTHIYVCVPSGGITRTIAVRRIEWVTLCPREDVADDDDADSHAGCTETSDSAAAPGGAGSDDPTKPLSTRKREKATSLFTSAFSQSGGIASKKELETPHTSRADVSPASSSHHHSSSTAAKVGRKVLTSAAAERSVTVVAIGIAQEPALALQFYSAVDGEDFVAALREASHMPTTAVFNVPNEEGPADVAGRLLPLLPGRCEGPIAPRALKREADGLNVDNHKPHTGDRRGVEKVQLSPPRSPRSPTAPPQPAAHSALLPQERRGSGGSDSSHGKRSRSRESVRTVEPEQAAQPCLGLSDRLLQHRSGDLPPPATSTAAYAPDTKAPWHSPLQEPSKSQRLTNGLPLERWTPSPLRAAPHREVPTPPLLKLIHSSPTEDRSGSIFCSHGINAIQSLHDAANETGRALSQEWLPDLTDASTTSSAMLKPAPFCHKVAAPVTSQKASNGLWRCRRDSTRVAPASLTPAEVTSCRSLFSGEVNTTQGVDPIPSTLLAAAPQTSSMVTRGGARDAPLDMNALQAELATQSTTVAQLQRTLQAHESLLIELANAKADLRGLWATLSERDAQCDRWQAACSQAEERVRVLHRQHECVLAEQKERLQAAHRAELETVQEAFEKYDAKMSAFVEQLQHSHRKEMAQWQHERRTLLFQLNEQQQRDIEVYHRLRAAEVAAQAQYEAQSRCSSAPHVHQYANTHAHQDACRSVKDKLERYNAQRQSSAVVAGAIHSPRDPGTLSRRGPQELSMQRNPVSAGWPLPRATSPSNTMPQLSAHRLLDSDPDVEDEVNQGHPTANYSTAALTQCSRSYIQAHLQTPSPFPLGDCIPSAADTGKGGHTLSRRSYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPZ2</accession>
    <name>A0A088RPZ2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heat shock protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_181330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697967.1">
        <property type="nucleotide sequence ID" value="XM_010699665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPZ2"/>
    <dbReference type="GeneID" id="22574023"/>
    <dbReference type="KEGG" id="lpan:LPMP_181330"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180016300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_181330"/>
    <dbReference type="eggNOG" id="KOG0103">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="434160at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11732">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSP105-110-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000171">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000004">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF4">
        <property type="entry name" value="HSC70CB, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="530"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="766"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="777"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="791"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN97314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="820" mass="91421" checksum="BABA1A7675268D36" modified="2014-11-26" version="1">MSVFGVDFGNLNSTVAITRHGGVDIVTNEVSKRETTTIVSFLDEERFIGEQGLDRYVRNAHNTVFLLKRFIGMRMNDPQLDVERKFLTCNITGDSNGRLMFSVNYCGEDKCFYPEQVLAMMLQRLRTYVNEAATTDPRVKADVRDFVITVPCYYTAEQRRLVYQAAEVAGLHCMSLINETTASAVDYGIFRGASLKETESEGQVVGILDLGYGVTDFLVCKFWRGNCKVLARTFDRNNGTRDCDYLLYQHMVSEVKSRYNVDVSENKRTRLRLLQACERLKYLLSANQSAPLNVENLMDIDVSIPSFERATMESLCQGVLQRIKKVMERGFAESGVNRDDFHSIEMIGGGCRIPMMKKLVEEVLGRAPSFTLNASETTARGCAIVAAMLSPKFQVREFKVSELPTYPILLGYYAENPRSPTSVPFLPQVNKVVKLLGAADSYPKKLDVRFPCSSAPRIYAFYDYENEGVKEIVQPCNYVIGEWEMGMPSKSKGAVNEMRVRICIQPDGLVELEKAEAIDVFEVEEAPAPAAAPAAENGEVPAKENEEAQADPPKPVKKMKEAAIGVPVKPNLEVLGHCSESVVRFRKAEEEMHERDSCIVRTRVKKNELESYILDYRPRFLPGGMLVEYATAAAAADFVRQCDADEQWLYEDGETSTYDEYERRVQTLRAIGDAAHSRLRNREEVEFAAKGFRARMAAAQQKALDFIGKKEHITEEELREAAATAEAACLWVDQQIAAMQAAPKTQETIVSKTDLDKKASGVEQGIAKVMKKPAPPKPKEEAGKAEEDAAAEAAAAAENAPQQEGPEEKAPEQTNAPVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQ03</accession>
    <name>A0A088RQ03_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kinesin, putative</fullName>
            <ecNumber evidence="5">5.6.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_181480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.3" evidence="5"/>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697982.1">
        <property type="nucleotide sequence ID" value="XM_010699680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQ03"/>
    <dbReference type="GeneID" id="22574038"/>
    <dbReference type="KEGG" id="lpan:LPMP_181480"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180018100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_181480"/>
    <dbReference type="eggNOG" id="KOG0239">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="123929at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000198">
        <property type="entry name" value="Putative kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="KINESIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115:SF948">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="4">
        <location>
            <begin position="1"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="484"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1019"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="878"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="486"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="522"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1029"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="98"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN97329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1093" mass="119870" checksum="43A4569CAFEC597C" modified="2014-11-26" version="1">MYSSSPPPSFSAAEAPTTHLHEEDRSAVLGGTATAGRSIGSRGRVLTITSPSTRERRQYEFGEVLEPEVTNTALCERLIPSITEQMAAGFNVCVLCYGQTGSGKTYTMNALAPAVAEEVFRSLDVNNEVVEMSYIQIYNNKAYSLLDGARGGKFGVELSRPLTSCTGSGSNGGASYLGSALEPKALIQSSAEVLKRMKAASRLRVTRAHTLNAHSSRSFTLLSLHITRFLDGAPLTTTRVTLADLAGTERLKKSGAAGEMVNQAIFINMSLMALRQLMESSGTEAEALHFRNSLLTTYLAPCMHSWHLILLVTVSLEAGSYEETKSSLEFATNARRRKVKKVKSRVENRLLSTVARVYGRPSSLSPAGAAGGAGSRSGWNVHEDNADNSERQGVIEVLRYRLRVLEETLKLEQQRNAMKVVQSPLTEVPADSQIAVPASVVDANATALAPAERLQRESQYYRHLLEEREQDLYRLQSHFPSANTKVSSVPSVLSNSPDTSSLSSEEADAGAGDDQPEFATPEASAESSDSSEVQVRASEVDVDDAHAHLLWCVRQLRSHGISEDEWGGDVLDRLRNAVLRATEQYEDVREQLLVLSSSLSGLRTQNHQLYDEVLHANRRLLAIDMERKEERAVLQASTRRAATAETVLEQLRLQLFQTYADQSIREEMTRLYLDAKPVTANVDEAVLDDRQMEQQVELEKVQAHQQVLCDKITELVDNVEQLTRAVAQKDAFLAALESLITPAQRALFHTLSNTATAIAERGTTSVGGSDGGLAGTTTAAIVVDDGRSTADCFSLLQSRVSELSSLLTQEQQQHQFTRCELLEAREDARRSRQEQRQAFFQQQEEARRVDQLMAENYELRQQNERHQFYLDQMCVSFNEKLLQLRHRHDEEMAELRSAAREARLRPDGNDDTVREACDKKGEDQDDAVLSIPVHASAHRGASQEVPSGEYWLSGGTALDSTAVAPSVADLVGSGDAEWRASSQQIQRPGRVQRWSAKSNERRRGKVHEAAAPMIDNAGATAAASVPSRGVRRSSKVARRSASIGKAKQRLFTTYGETANPSDASAPLVKSEVIASAPLNKRRRVRASGAAGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQ15</accession>
    <name>A0A088RQ15_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA polymerase eta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_210660</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698854.1">
        <property type="nucleotide sequence ID" value="XM_010700552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQ15"/>
    <dbReference type="GeneID" id="22574888"/>
    <dbReference type="KEGG" id="lpan:LPMP_210660"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210011300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_210660"/>
    <dbReference type="eggNOG" id="KOG2095">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5723at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009314">
        <property type="term" value="P:response to radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000008">
        <property type="entry name" value="DNA polymerase eta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000102">
        <property type="entry name" value="Putative DNA polymerase eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052230">
        <property type="entry name" value="DNA_polymerase_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873:SF1">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UmuC" evidence="11">
        <location>
            <begin position="4"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="643"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="343"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="643"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="671"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="731"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN98147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="742" mass="79811" checksum="8D55CB51EE23B4EF" modified="2014-11-26" version="1">MRCIAHVDMDCFYAQVEAVRLGLDCRVTPLVLAQWGSLIAVNYPARARGVKRFSRVSEAQALCPELIIALSPSYRMGEATYQYHPHPVPDSYKISLEPYRHASRQIFAILRSEPGVMVGKAGIDEAYVDVTEAARRELAEVRAAAAGASLDPLVDVMEPSTRLIEDRRAEMEAWLCARGTSLAAVFDEPMRALVRGECGAGLEGSRAFCVGADDAAYAERCLLLCAASRVVHRLRQRIYAELHYDCSAGIAHNRVLAKCISARHKPNQQTLLLPDRGASALFELPLSGLRGFGGKLGAAVSVVCGGVTECREAWLVPLAQLYKLDGTHDVGVGADAEEDGERRKSRPLARKRRRTALSSLERDHQGLVAHTTSEYVFYLLRGFGEDTVSNRPLPKSIIASKNFGRVTTSAEVVRSWVTVLASELCSRYNEFTALYHLRGRSFNIKLGNSGFRSMSGLSSNTVALPEAIQPDVLAAVAMREVHAVFRNKPDAAADSVTLTIGGFVSDGTGETGAVPSLTAITGERTTAGKKRVARGHTRQQTLLSSFIAAVADGRGTGAACQQSGDGVEEILSGDERWLDDSDSNDSVHIEDDAGILSLSSHSLCPSGDDTSSVVLVGETPPLHECDVVPETYSVAKVRTLDVSESSPWEAATAPPPPTLLFSSPLPTGKAASEESPEKSHSVTKHREEHQHHLGGHSHVVSRPAPPSVLALPFLSPPRSSPTSANTVVFNGEEDEDGVTVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQ84</accession>
    <name>A0A088RQ84_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_205330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN98025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698732.1">
        <property type="nucleotide sequence ID" value="XM_010700430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQ84"/>
    <dbReference type="GeneID" id="22574745"/>
    <dbReference type="KEGG" id="lpan:LPMP_205330"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200060100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_205330"/>
    <dbReference type="eggNOG" id="ENOG502SGYZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270485at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="299" mass="33728" checksum="41E5DAA22148B4ED" modified="2014-11-26" version="1">MQRLDIEQQFRLREAEKTQRQAAETALSLSYLHEEYYAAASNAIILFSGICATTGVLFLASALLIKTRLTNTVRMSFQCSGVSLIPQWTSPSVFSICMAVWMGLLGMQVVCDVLREVAQQHYRTIKETNVSSLADVSLLHRIHVGTVNPHPLWGLSTEITEQYPPLIQWVMTPTALLFAAQYAGMVCIWCYMLFFGRPPEAGLMGALLAFFPSFYEALLLSGNEPHRWVVWVTLVNFTLALVCLWSFGAPLVWREYREVMKELQGHTAQALFKDRSETRKMHARGAARVGGACKKWKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQF8</accession>
    <name>A0A088RQF8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_220580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699059.1">
        <property type="nucleotide sequence ID" value="XM_010700757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQF8"/>
    <dbReference type="GeneID" id="22575104"/>
    <dbReference type="KEGG" id="lpan:LPMP_220580"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220010800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_220580"/>
    <dbReference type="eggNOG" id="KOG0419">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9984419at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000090">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2-17 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="90"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="260" mass="28490" checksum="8ADE6530E26EB866" modified="2014-11-26" version="1">MQAARLATRNTTGDGEDGPQRAPVDAPMTTAATVEQETAHPQQPVGEPMTTMEQPRFQSPSYEHLAARQSRNSAIADKMGGGQQLKDHTTAQRRLMQDYRTFQQNMAEGTNSDITALPVDGDFFHWHAVISGPCDTPWEGGLFKLDLIFGDDYPFSPPKVRFLTKGMFHPNVYVDGNICMDTLKGNWQSSLNLETLLISIQSLLSDPNPLSAANGAAARLLTENRSAYDEKIRALVEESLEQSFSVDGDSDDAAVNGEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQS9</accession>
    <name>A0A088RQS9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="9">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_200820</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPP phosphatase family. PP-1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="9"/>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698281.1">
        <property type="nucleotide sequence ID" value="XM_010699979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQS9"/>
    <dbReference type="GeneID" id="22574289"/>
    <dbReference type="KEGG" id="lpan:LPMP_200820"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200012200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_200820"/>
    <dbReference type="eggNOG" id="KOG0374">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000047">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF396">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="125"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN97574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="304" mass="34768" checksum="48110B28C0D18038" modified="2014-11-26" version="1">MSNSSAPTSSGVPQMLIEKLLAVRGASSQRQVLIKEDDIHVVLETVREIFMSQPMLLEIRPPVRVCGDTHGQYYDLLRIFEKCGFPPYSNYLFLGDYVDRGKHSVETIILQFCYKIVYRENFFLLRGNHECASINKMYGFFDDVKRRYNIKLFKAFTDVFNTMPVCCVISEKIICMHGGLSPDLIDLTTINEILRPCDVPDRGILCDLLWADPENEVRGFLESDRGVSYLFGEDIVNDFLDMVDMDLIVRAHQVVQRGYEFFASRQLVTVFSAPNYCGEFDNDAAVMNIDDKLQCSFLIIPGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RR95</accession>
    <name>A0A088RR95_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldose 1-epimerase-like protein, putative</fullName>
            <ecNumber evidence="4">5.1.3.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_230470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldose epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.3" evidence="4"/>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699205.1">
        <property type="nucleotide sequence ID" value="XM_010700903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RR95"/>
    <dbReference type="GeneID" id="22575251"/>
    <dbReference type="KEGG" id="lpan:LPMP_230470"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230010100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_230470"/>
    <dbReference type="eggNOG" id="KOG1604">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="274691at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09019">
        <property type="entry name" value="galactose_mutarotase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018052">
        <property type="entry name" value="Ald1_epimerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047215">
        <property type="entry name" value="Galactose_mutarotase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF0">
        <property type="entry name" value="GALACTOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00545">
        <property type="entry name" value="ALDOSE_1_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN98498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="408" mass="44444" checksum="24959FC373C73D56" modified="2014-11-26" version="1">MFGSQPVPATATPAHGPQVDPFGESFAITLSSEHLRVQLLSHGAALNSVKVRKPHAAASGSAAAEQDGEWMDVCLGYTNPEEAFSTDAVIGHTIGRYAGRIANGELEVKNVPYTLAKNCGPHNLHGGPVGFQNKEWKYLLSDGKDETSVAFHLVSPHMDQGFPGELFVTATYSIIKSAPAPTLKYVLQASLSDNTSVDMTVINLTNHAYWNLNGVPRPAEADAVAPLPRSITNHYLQLQSRYFAVTDESSIPNGDMRPVEGTLHDYSELRCIAEGMEATKEEGRDGGGYDDPVALETWDSTLREAALLYSPATKLRMRVCTTNPVIVVYTANALPADASGAKGQRFQRHSAICLECQYFPNSPNVPAFPSTALKKGEAYKETTTHEFQFMNADITPEERQQRHHYPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRT6</accession>
    <name>A0A088RRT6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine/threonine-protein phosphatase 4 regulatory subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_240180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98653.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699360.1">
        <property type="nucleotide sequence ID" value="XM_010701058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRT6"/>
    <dbReference type="GeneID" id="22575427"/>
    <dbReference type="KEGG" id="lpan:LPMP_240180"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240006600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_240180"/>
    <dbReference type="eggNOG" id="KOG0211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="340346at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000909">
        <property type="entry name" value="Hypothetical_protein_-_conserved"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039918">
        <property type="entry name" value="PPP4R4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21467">
        <property type="entry name" value="PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 4 PPP4R4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21467:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98653.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="812" mass="91030" checksum="A172AEC3D9AF05BE" modified="2026-01-28" version="2">MDYRSPFELRQQLLEGVRAAQTTLPPKKTKCKAKGGYGDNCATPLPTQYSAGKDSSGFMPFTALPDDPTALVREVPGAENIEALNAALEREEAVQRYVEKEKLSVEESAKYIMANGSTGQRISYFAHIREQLVELPSKAISKVLETLLDSMWTQDPELQCRAPENLLKLVGLLDSDTATEMYDVTKTMLTVQMPEIRVAWCELLLGLIDYLPVSVLQSDLIILTVNKSEHAQSQDQRELSCKLLGALCQHMVADKVEELILPRALALCQDTNVGVRQRMCQQLCAIAHSLGVEKAKIRVAPDLFELLTDEEQVVSRAAFSCLIDLVEFFGSVYRREKLFPIIKNFISNPPSEVFGLLVGEFGRFLDAIKTDIVSEDDVTLFANFFCTAATRHEEDARRHCAFNFPAVVASLPRSVFATHLSKALLSLSADSCVAARLSAASGMHELLPLLHTPAADLLERPFLRLIADPDASVRAALVQHINNLLDYFRSELKNSDRLSFFSAVLDSLLAWVSEPVVNWRTMQHVMQIVDHYIDLFEERTLTEQVVPRLWEYAKTGATILKADCATLIMHIASRIVNPITKAQIFSRLNSEYGRSTSCYARQTYIYFVSVTFRFFSLRCVRERMLECCLELQRDSVTAVRLALARSLPLLSQTLRKSNAGALEDEFTAMIGRLCEDVDEEVREEAAKYAVGCKRRAGEDTAALRRSHGNEEEDGRREKAELAMLEHAKETDKAERRAKLRDLLKSEREKELVELPSPLKGRKPVPPASTAPPPLTRRHGSKHFILPPVNSVSLPRIAPTKQTPARSTSRRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSD7</accession>
    <name>A0A088RSD7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_241730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699512.1">
        <property type="nucleotide sequence ID" value="XM_010701210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSD7"/>
    <dbReference type="GeneID" id="22575582"/>
    <dbReference type="KEGG" id="lpan:LPMP_241730"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240024600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_241730"/>
    <dbReference type="eggNOG" id="ENOG502S6WX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272543at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2380.10">
        <property type="entry name" value="CGI121/TPRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036504">
        <property type="entry name" value="CGI121/TPRKB_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="271" mass="28880" checksum="803C2E5F86EA1461" modified="2014-11-26" version="1">MSLRIGSFAVRCYHDCTNAAAIHAEMKRRHIDAAVVDHAFLFSPLQLAVALFRVEASADALATRVPSTISLLSAEAPSPSSASTDTSLPSSPPQQQQQLAHRLSSSRQIFAALSLSHNLDRILQVLPPGPQTTSVVIIYKYSGSTHPAAVSATDDVRADSVVASAVQDGENLDAIIHACVQVTNSTAQSHTFAPITEPFWTGSAFALADASKVALFYGISESMLLAAQRSMTRLDVRRVCLGTPSQAAQMQLLRWHALEICVTTLLAACTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSU4</accession>
    <name>A0A088RSU4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BAG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_220140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699016.1">
        <property type="nucleotide sequence ID" value="XM_010700714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSU4"/>
    <dbReference type="GeneID" id="22575060"/>
    <dbReference type="KEGG" id="lpan:LPMP_220140"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220006600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_220140"/>
    <dbReference type="eggNOG" id="ENOG502S2ZE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="247597at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.120">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036533">
        <property type="entry name" value="BAG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003103">
        <property type="entry name" value="BAG_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02179">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63491">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAG" evidence="2">
        <location>
            <begin position="395"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="454" mass="49392" checksum="01F25D2630602E67" modified="2014-11-26" version="1">MPYYGYEPEQTKAQIRSTRGETIDLALPVTCLVGELRTFLIKEYGYDPNTRLLYNGLVTDDNSYVCDYPFGSLIIALPADTQPQHQLPSPRHPTAAHQPPQKQHALPEPTHPATHHFSTASTSADAIRKNKSVEVMPTHTNAAARKMSPTDTPLEIAKAKRDSTVVKDRFKNSARSVLSTSSERARSHSRPTKVDGFSAPTRTFPHPSTPTPPPVLAPARNGPSPAPGSGRAVSGTSARSSPWPQGSQDATEALSSAASSQAANLSPSPHSAQSSAAAEGLSCEDSNGDDSQRRRVRLMVECNIPSLNQVVSIPINSEFTVLDLIRAVEAAVPTLTPEAQVVYRGKLLPKSLQAKLFDSGIRSDARVFIAAGEYSNTEKITLLEIEADTAVIESAMKSPLTDPQRKGYYEELMRILFRTDGLQSLEGKWRQRRKDVVNHITSLQDKLGVDIKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSU6</accession>
    <name>A0A088RSU6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Enoyl-CoA reductase, putative</fullName>
            <ecNumber evidence="11">1.3.99.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ENCR</name>
        <name evidence="11" type="ORF">LPMP_251850</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.5" evidence="11"/>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699755.1">
        <property type="nucleotide sequence ID" value="XM_010701453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSU6"/>
    <dbReference type="GeneID" id="22575833"/>
    <dbReference type="KEGG" id="lpan:LPMP_251850"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000017200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_251850"/>
    <dbReference type="eggNOG" id="KOG1639">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="540503at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003865">
        <property type="term" value="F:3-oxo-5-alpha-steroid 4-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF28">
        <property type="entry name" value="VERY-LONG-CHAIN ENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="10">
        <location>
            <begin position="164"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN99048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="309" mass="34547" checksum="47E03471FAEBBB88" modified="2014-11-26" version="1">MKVIVASGQNGSRKHEVELAANATLADLKKAYRSEVDVHRKSFKVPGPIAAGGSAPTADGTKPRPNLITLSEKMPLSQQGVKDGTVITYKDLGPQIGYRTVFYVEYAGPIAFMLLYAMRPSFIYGSAPMPAYGYTQKLYIGLFIAHFLKRELESMFVHKFSHPTMPMRNIFKNCIYYWSFAAFIGYVLCSPFFTATSAAQSNFGAVFMVINELLNFAVHYQLSTMRKSDGDTTRNVPQGPLFALVSCPNYFFEIMSWVSFSIGTNMLSSWFFTLAGFVQMADWAKKKHRGYIKADPANKKKAAILPFLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSZ0</accession>
    <name>A0A088RSZ0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldo/keto reductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_261190</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699939.1">
        <property type="nucleotide sequence ID" value="XM_010701637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSZ0"/>
    <dbReference type="GeneID" id="22576022"/>
    <dbReference type="KEGG" id="lpan:LPMP_261190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260016800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_261190"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="28"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN99232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="421" mass="45130" checksum="3D5E95419ED671B6" modified="2014-11-26" version="1">MQCTVGATPAAAAAASGLPSLSFGVPPIGIGTYELRGDACVNAVRASLQIGYRLIDTAAAYRNEELVGEGIASSGVPRADLFVVVKIAMKSMGADEAVRQGVLDSIRKLRIGYIDCVLMHWPGCGGLKPQDAAGNQAARARCWRIMHELQKQGKVRYCGVSNFLPRHFKELNCFNDSDDGQHTESEALAAAAQLRVLSTSERKEEDVVHGHYSGSSGGCPSSSSAPALPSTSSELCLPPILNQIELHPLCIQRDVDMYCRRRHGMLLQQYSPLGKGDVRLLQHPGLLKVHAQCFPSQSGGNHASAPVPGASPEAAKSYSVVDMILMWGLAQGYCVLVRSHRLDHLRANLDAARDYFASVKAVAKEMGNSGGGSADESMASASTARALLTAEQLDVIQHLRVHIGVEDDQDMHLCWYSSQIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTC9</accession>
    <name>A0A088RTC9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_261200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699940.1">
        <property type="nucleotide sequence ID" value="XM_010701638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTC9"/>
    <dbReference type="GeneID" id="22576023"/>
    <dbReference type="KEGG" id="lpan:LPMP_261200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260016900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_261200"/>
    <dbReference type="eggNOG" id="ENOG502QVZZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1904536at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050576">
        <property type="entry name" value="Cilia_flagella_integrity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973:SF9">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="142"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="253"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="527"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="606"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="646"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="259"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="532"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="552"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN99233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="666" mass="71907" checksum="D2A6638BF16A3BDB" modified="2014-11-26" version="1">MSSTGISSTNGVTSTAVSDTSGSFAAPLDGASSTTNMLTTDAIIRECIKQGFYRNPICNEKLYLHNRGYDSIASTAFEPYTDVKVLWLEGNGFSVLPCGKGYTQVRPPVRVDPFAAELEVAEAERAAAAAVLSKCSGQHVDPNTEAISHPDSPSQNGVAQKEPSLPLATDVPPNDRDVFSSLYPTVRQLYLHNNLFRFMPDLSRFERLDAVNLSGNFFTTVEPHCVYYDAAVRGRHASEVVDGVAPTSTIVSGARHSPSQSVQCEQEQSCQQLPHGPHSTNETAPSAELAVVTSSDDAKRQRAGQMARCRHVADVFSVFCKHSPLPESEEAKEVRGEGHQGRVSSPLLKQPLPLAPEYRNPCSSLRSLNLAGNRIESFEECLGLLCYHSLAVLDLSHNHIADGEALLLILERLPRLQSLKLSGNPLVRSLPRYRKRVLSRCKRLLHLDDRPVFAEERRLVTAWAIGGEDGEEKERAAIQQEKSAAEKKRLADFRRLISRHQRTDPTKGPHADYIHAITTVAALSAAADTAGSHGQNSATRSSRAPRHRDGRPSTSDPDSSSTSSESEGDSDDDNHVGRGAGEQSAVARTTVIAYDSNTAAQAGMIVTQQENNPPRETPYSSSSQQQRGLNSNQRVKAAVSIAAVGGATGSGEDDGESGDIFVPNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTL6</accession>
    <name>A0A088RTL6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-oxoglutarate-dependent dioxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_271150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700204.1">
        <property type="nucleotide sequence ID" value="XM_010701902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTL6"/>
    <dbReference type="GeneID" id="22576293"/>
    <dbReference type="KEGG" id="lpan:LPMP_271150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270018700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_271150"/>
    <dbReference type="eggNOG" id="KOG2131">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="203487at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02208">
        <property type="entry name" value="cupin_RmlC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050910">
        <property type="entry name" value="JMJD6_ArgDemeth/LysHydrox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480:SF6">
        <property type="entry name" value="2-OXOGLUTARATE AND IRON-DEPENDENT OXYGENASE JMJD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480">
        <property type="entry name" value="ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="176"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="484" mass="53928" checksum="6369B34CAF241E32" modified="2014-11-26" version="1">MLELDGTTLTYEVFRAACLRPNRPAIIRNACRDASDGICFDLAALKRRLCPRELCRSLGSRALVPVYPVFSTVQVASYDSTPAARVERLHEPPTTVKDEEREEDEEGCCKEVPLEVVLRSWATSASAAACSLSQPHVYYLKDWHLQATLENTATTAITTASSTPSSQRSEYAKRRASGTHGDGLYRVPKFLGADWMDSFCSRNVMPSHDVHNRTSPADDTGTRAHMGFGDSESDYRFCYMGPVGSWTPLHCDVFGTYSWSFNVCGDKHWFFPTMAGNAYLHTHLLPLFPTPSDIRVLTGFELDTVVQHPGDLVFVPALFYHQVHNISGEVLPLFVDEGVATEEVRRRDGTVMSFASAEVNAQLSAALTVALNHNWCNAFNVGRMAAAFLADARQLSSHLSTDDLAVICDTHDPAVWRRFADRMLHNGTNWSFASMNCFLDYCLARLDLGADVTDGTEDERNAAADELRRLRVRVADEYARLFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RU16</accession>
    <name>A0A088RU16_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Heat shock protein DNAJ, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_272430</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700329.1">
        <property type="nucleotide sequence ID" value="XM_010702027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RU16"/>
    <dbReference type="GeneID" id="22576421"/>
    <dbReference type="KEGG" id="lpan:LPMP_272430"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270032400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_272430"/>
    <dbReference type="eggNOG" id="KOG0712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000033">
        <property type="entry name" value="DnaJ family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000074">
        <property type="entry name" value="Heat shock protein DNAJ, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0346">Stress response</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="6"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="8">
        <location>
            <begin position="120"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="5">
        <location>
            <begin position="120"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="346"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN99622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="396" mass="43402" checksum="A1F12E95E1CA2A94" modified="2014-11-26" version="1">MVKETGYYNALGVSPDAGEDEIKRAYRKLALKYHPDKNTEPGAQEKFKEVSVAYECLSDPEKRKRYDQFGKDAVEMQGGGVDPSDIFASFFGGGGRPRGEPKPKDIVHELPVPLEAFYCGKTIKLAITRDRLCSQCNGTGSKVAGVSATCKDCGGRGVRMVTRQLQPGFIQQIQTACPACKGKGTSLREEDKCLSCRGQQIHKDKKVFEVVVEKGMHRGDSVTFSGEGDQIPSVKLSGDIIIILDQKPHPNFIRKGNHLLMEHTISLAEALTGFSLNITQLDGRELAVSSSAGTVIDPATMYSVNREGMPVAHTGGMERGDLILHFRVVFPKTLRPTAVPELRKMLGYPQQPPTKDGAETHTLQESHVDLEKEARRNAYDDDGDQPRVQTAGCAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RU20</accession>
    <name>A0A088RU20_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_271380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700225.1">
        <property type="nucleotide sequence ID" value="XM_010701923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RU20"/>
    <dbReference type="GeneID" id="22576316"/>
    <dbReference type="KEGG" id="lpan:LPMP_271380"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270020800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_271380"/>
    <dbReference type="eggNOG" id="ENOG502SIFI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273760at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="313" mass="33945" checksum="2D40C7B2474B88CD" modified="2014-11-26" version="1">MRNSKVRPPPPPRRAPPGPAFVKMSSNTHIFSHTLLHLSGVALLSQQLLQVKDSVNDIKVAIVTADDSLKAISVNPAVWPSSLCDGATTGGDDVQSLAFASVTLSKLAEEEKAQDAFYASLSEMATVRAEVQKGSRDATLQRYKQQVECQLASSVVNRSLPEQQQVLLNPYSTVRRKILSTLLTVSPFTTTPNATAESLYRPTSATKTNACRPPTSSVAPPQQSSSYSIPVGSEYNSPYPFTAEGTPSSVYARYGAMTAPQQPSQTPPPVRYGAYGYESLPQNGTATDGVRYGQQQHLRRYQQQSGRPHYQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RU26</accession>
    <name>A0A088RU26_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNAJ domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_241060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699446.1">
        <property type="nucleotide sequence ID" value="XM_010701144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RU26"/>
    <dbReference type="GeneID" id="22575515"/>
    <dbReference type="KEGG" id="lpan:LPMP_241060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240016600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_241060"/>
    <dbReference type="eggNOG" id="ENOG502R90M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050817">
        <property type="entry name" value="DjlA_DnaK_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="369"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN98739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="429" mass="48818" checksum="8B55925012DDF664" modified="2014-11-26" version="1">MFLRTRALCYTVHTPRGINFDLSADDAICRIQDKYGRRWFGAQLDYLRLDTPSKEFLPFYLCSGRIHASFVGNVSYSVNTTSGDGSSKRSSTRYVSTSLQTLDSVFEENKTQIYAGYKYNIAHVHHALRGDQLSYSLRKMYEVDTTGATINLFEQSTTTMMKFVEMEVRQQAEETARSLVRSFHPSADSVAVEFKEFSFHLDEVTPTFVPCFVVKAEYDVERYTLYVSGLNGQVGGPYLLNSLYIARTTALATLAGVMLLVPNKVAGFLFGSVACVATYYAAFFAARWFPAIRRNWNRRHRERLRRENLGIDQGGYRPNTSSQRIQQEYHSSTYWDTHAYQQRRHSDWEGPRSASSSSSSTQSVSDPLGYYRALGLHGNESVNEIRSAYRQIVLKQHPDVGGSNEAMVKANEAYRVLRDPKRRAAYDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUX2</accession>
    <name>A0A088RUX2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATPase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_281900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. PCH2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99823.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700530.1">
        <property type="nucleotide sequence ID" value="XM_010702228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUX2"/>
    <dbReference type="GeneID" id="22576635"/>
    <dbReference type="KEGG" id="lpan:LPMP_281900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280025500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_281900"/>
    <dbReference type="eggNOG" id="KOG0744">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051598">
        <property type="term" value="P:meiotic recombination checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001527">
        <property type="entry name" value="AAA family ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044539">
        <property type="entry name" value="Pch2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058249">
        <property type="entry name" value="Pch2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991">
        <property type="entry name" value="PACHYTENE CHECKPOINT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991:SF1">
        <property type="entry name" value="PACHYTENE CHECKPOINT PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23242">
        <property type="entry name" value="AAA_lid_TRIP13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0469">Meiosis</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN99823.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="583" mass="62474" checksum="F468F5A63052AA1A" modified="2026-01-28" version="2">MMLRQTSASPLSPEGKSARYLVVIEVRTTADTAAWPELSSLVRSYVRVQASRRLTAGHLPPFLPGATISLADAPPLLRDDVVSVRVCDVSFPIGCSWTNVEDVCFCMRLYRLCGEAGCAPLSAVASTPAAQSSLPAWCTADHMHRGGEDDNTSSFTLTPLPHVSLEGQWESLHYGESEAASIAFKRDIVSYVDTAMRFARAGVSPNVVAWNRLVLFHGPPGTGKTSLCRALAQKLSIRLASSVYARACLLEINAHSLFSRWFSESGKRVLELFEQVRCIADDKECLICCVMDEVESLAAARASAMKGNEPSDSIRVVNALLTQIDRLQDCQNIIVLATTNLTAAIDTALLDRADKRVHVGPPGLQARFLILYASVQELLDKGLVAAPQAGTSVLPDEPNWLSAANEPSEKGRAVPEGNVGTYGSLDSHSLNGGGGTSDAVHMWNEELNASHDRSSRFHKPPLEAMASPTSLGTVSAPHPAHHQPPLHCLSGAAYTISTLLHHIAEVCAGLNGRTLKKLPFLAYGACMCSFSSSSGCVGSESAWQVNQSGRVDAPLPLRDYLEALFKAAQEAAAMALFDANRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RV59</accession>
    <name>A0A088RV59_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_290970</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00048.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700705.1">
        <property type="nucleotide sequence ID" value="XM_010702403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RV59"/>
    <dbReference type="GeneID" id="22576861"/>
    <dbReference type="KEGG" id="lpan:LPMP_290970"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290013800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_290970"/>
    <dbReference type="eggNOG" id="KOG0065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF91">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO00048.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="721" mass="79544" checksum="40D9BD1FB161E9C1" modified="2026-01-28" version="2">MISESTPLVGNSTAHSYQLSDGELCARRCSENSCSAEVRNQRMRQYYHSVFCSGGIDVAVRNVAVVQRPWLQRCYPNRRRGRICCQGVSAQFRRGRLHVVADVDGIAASSLMTVIAGRGTQASGDIWVDDVAVDAQTRLRLIAYVGTESLFIPFLSVHDNLWFVVYLHRKEQRSWTQELVLAAASFVSLDLRKKVTDLSQSEKFRLQVALELVLDPPALFFSYPFDTMGLVEQNECTQLLSRVCVVMMKTVVLSTQLMPMSLHSAADTLLLFGVGGVVLFSGKCQDAISYFNCLCIPKHVPQPLWKEVLGPGLEAHFAEEDRRTFHAVSFPTSNSSSLSQRFVDGSGSLLYSALCTPPRLSSRLFLLDDLNGTSPPPVYRRTAEGDTAPPSAVVEVATSGDLMDLAVEWAESESQTMFYAAKYYDSSVHAALLSSLDPATTRSPTTTPPPLPPLRALPTCVWRFGVLLTYTLKQIVADAELLLGVVLLSVGLLVLTVAVHSQPENQGGMYNIRGLIFIAFVLVLLSNLAAIESMRGQLRVALDHRKRKLYGSLSFIVCLGVRVVVIRTVYLALFLPFVLFVLRSSYSLAILVGLVSCTHAAFQYLVALLPSRRWVIWVSYAYFGYSIIFSGFLLNLRTLPPLLGVLSFLRWGYGAVIYAWLHGKAFQCDGAGNTSYCYTGDDYLAMEGLQDESVMSSALTLAVLGASMMTLLLVLWSLRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RV78</accession>
    <name>A0A088RV78_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mitochondrial RNA binding complex 1 subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_281920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700532.1">
        <property type="nucleotide sequence ID" value="XM_010702230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RV78"/>
    <dbReference type="GeneID" id="22576637"/>
    <dbReference type="KEGG" id="lpan:LPMP_281920"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280025700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_281920"/>
    <dbReference type="eggNOG" id="ENOG502S6GE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="278493at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="CDD" id="cd23679">
        <property type="entry name" value="RESC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058774">
        <property type="entry name" value="RESC7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26165">
        <property type="entry name" value="RESC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA-editing substrate-binding complex 7 protein" evidence="2">
        <location>
            <begin position="60"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="145" mass="15388" checksum="A4C24E0F87A1146E" modified="2014-11-26" version="1">MYGSVNVSAAADASAGRATASCFLIDARRFYFASSRVCMDETSSTAGQHQQKTSDSGAPAETSSAAANDRESALDVAMRVNKMKKAHQSGGAGANKKEMEQEAWNALNSLTEDQINNAEGKAVSLLLNAWAYFAKFWAKGKDGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVF0</accession>
    <name>A0A088RVF0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_261060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699926.1">
        <property type="nucleotide sequence ID" value="XM_010701624.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22576009"/>
    <dbReference type="KEGG" id="lpan:LPMP_261060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260015500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_261060"/>
    <dbReference type="eggNOG" id="ENOG502S7H3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266786at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="634"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="841"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="930"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1096"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1257"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1308"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="846"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="945"/>
            <end position="962"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1902" mass="202014" checksum="FF5FD502620D68E4" modified="2014-11-26" version="1">MQKALGGLCSASPRRGSGAAAATLHRTTPAQSQRDDNNADDSGRHYDGEYDRLIFSPIHPNRAAFTAAPGSLLSHNSVHHYSESPPLSNARHSPPSRGLITASQAAAALDRLPELPTSQRRQAASSAVTALIAGRAAAASTLSSTSCRPCSKTPPAVSTDALPLQPEAWWSTLDGTLSATNTLLGDESQQLYHIAETPAPAPSHPFLTPSLNSTLGRADRAAIVLSTHLSRHTNLAPGGSVATGVLRAKDGDADASVSSADRTIKDDEATAAAVAAVAMRLSCATAGSSLSGGFSGAANTMLSNASRGSGRQNTLQRLRETLRRTQSSPVELEIPAPNIAPHCLDVSEEGYGSLSSSNKQSKPAPSRTTGTSRTHRWISEGVAPPHGSQDGGTGIIKRGGGTQRIRGPAVHLYAQNAPRAPAQVMPLLPASRAFLPSELLPGGTAGDRAGKVMRGLHQAPSAIGSRMHNSETSFVGSTADPNAATQEGAGTHTDDKDGRMNAASHALPPPLHRHRVAVAVTAAKPALTLPWERDRLTLEAMERRYGAQSAVHTLRRRRRYHGYRRSEVPPAADRRPRGSHAETLALLTSPVASSVPTSDFSAASLTSSIFIRELGEVEAARQMLEKHRWRLATPREAVSSASDDVAQRSRSPSRHGTSGTQVHLPHGMTGKEAAAKAYRQEQLRLYVSHLTTPSTLPTDGPVAVEQGQLDAGRPLRGTEHHTAGASANDALLACAPGGDAASSTRRSRAGAATFGASNTAATVAKATASKLTAVATSGRNALDRALQARAALLRRHAQDQSTWKRQLHQVRQWCDRTHVMVRFDNGVCAEQMAAAPLHRTVARQHQRQDRQEATEVSHRPSSGDAHVGAGIFVTKMSDDAAGQHFVYVDDPIRAHDAVMQQLAEEDNEVQRQNELQRCRERRHAPSLEWCIGDSHASPPAPPMQSVASSRAAAQAISSSSLSHRSENHDATRTQFSGAVDAGWDLLKSMPLLIGLDTSPAPLQVGQHSVQFVISATDELASKGTSSVLLSQASPLSIRPPQMSMHTALCARLQTWGTDVAEEEEALSRGGSTTIDTAALPPADAASAGLNACTAPPTWQGARKGSAPCSRRATLPADLSENSPGRSANESKGEPGDLAQKRTTQHGATPSLIHLQRASLSQSVQAILTRVERDLLSFVLTCASGDGGVERLAALFSLCSGRRIDNSAVECPSDSAAGEGRSLATPLPPALVALLTMLDQSPQTLVCDGTAVKAAVAQETSSSGATEAKEQHGVGRESPLASPRDLEVKITQETTDVRGDAYAVAGFPRIDHESGNGKGSAATTLPTDRASAAAPTPEKTVPPWSALVTSLLSGYNILDLSFLRQLHLLLWHYETQEYKRACITVAETSKEVVAQSALPPPPSTTMPYRSQRAPPAVFPLSLQLSTSQEPRMDFRTSFRLSDSGRSTLSTVLVDAADLLNAITATTLLRWLCDACRQSPTSSWAELVERVPATCAQDWQNALMRCIEAASSEVHPPQCASSKASLWSDELRRLSAPFPTGPAATTAPPPSPRQLECFAFDTASALESVKWRLRRIHDVLHRASLRAEQERITANTAAATDATVGTLFTAGSTSNAVPAAFPCVGDTPYLPGVEARARYPLDMRSLYLLSALAAEDIDARVVPQLREARVQYADALQAATATGTLVNVSGSSSVSKISPLAFSRSAASLPLALQQRVPLDRLFQIEQRFVRLLSALWNAEQSIFAFNRHVAPFNAFTAAEQRCWGSLYRSSLKVAYFVCEELTEKGMESVSTELLPFVSIVASFTGCCGGHRELLSKLNAIMLDLAERAKKVQVPLESLSWQKKRPQVLAEAIAASKIACRRAAAVVSCLTTEADVVGLPLTELAMPALRLIHVLPLSQLPGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVY8</accession>
    <name>A0A088RVY8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial oligoU binding protein TBRGG1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_300830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701118.1">
        <property type="nucleotide sequence ID" value="XM_010702816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVY8"/>
    <dbReference type="GeneID" id="22577137"/>
    <dbReference type="KEGG" id="lpan:LPMP_300830"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300013700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_300830"/>
    <dbReference type="eggNOG" id="ENOG502QS3C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273156at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="695" mass="77842" checksum="EE549E2C815AF449" modified="2014-11-26" version="1">MSLFPPFLRARLKQADFSLYFIISMSPQRYLHPRPLIKRLERERTAKDQMLQRCATLAGTPLWARGYSTALSGCAVLRQRGGYQGRGGGPRRGGGGDRGYENHNQGYANHQQRYDDRPQRHDIYQQGYSNRRQNYDDRNQGYNNRRKGFNNRQEGFGNRQDDGDDRQLAPRRSKEQYLAQDADKLLKMKHEYKKAKDTKERFGILKEARRLLRRIRIDPSTQDERSVSIVINCAATFSIPAKTEAVEQAFQWIRSNIGGISPQNIALFANALGVIFPPEAKQVMVGEVMPIVQLVMREMVPVEVVMVLQALQRLRVTENEKLQDGLLSHLEPCLSSMPVQQLSTLASVLHHHSMQTRDNAKWKQIAHETLARALAGVEGMHSREAIVLLCAAPFVDASQKQISQLLVRVAETAQFHTDEQVGELMNAILRIRQQVSEPSVELTAAVEGLHTALMARLEKVSAFVGPRSATHIWNYAHASNIEISSTIQESMCASLIRLMTFRTIPFQSLVRLMASLSTQKLPSAEILTVTANCSVGVRPPRPARTAPQESEMPEDGEDHETIRAAAREVLYSRHFGTLTELRINLENAFAKNDVSPNDALAKTLPEHLLKHASEALPRQMLTAVAAIALAPADCPCRNKTHDAAVCATVLKTLEDSPERFKSDLSPVFVDWFVRSIPADSNSEAIVAAVQRITAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RW18</accession>
    <name>A0A088RW18_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_270820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700171.1">
        <property type="nucleotide sequence ID" value="XM_010701869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RW18"/>
    <dbReference type="GeneID" id="22576258"/>
    <dbReference type="KEGG" id="lpan:LPMP_270820"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270015200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_270820"/>
    <dbReference type="eggNOG" id="ENOG502SGS4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272873at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="476" mass="52949" checksum="0C1249C44576D1EC" modified="2014-11-26" version="1">MPSATAHGSLSASSPEETRRTIDSDCPLFNCFGVLSGGVIIDPIDESFVEFTSSVVYTPSTMAVDDDTEHSTHDSPARRTLQQANEHVFRTGETHLIRPECPLTVCTSELPLPPSGSDPCPKHFTCRTSSFSAAGNTGPTVTSPRHAVKIGMDNVNRWLSRLATRPGHQGQSPKCQAWRTVWTDAEELRLFMRSHRDVRGSGVSLYLPPRLPFPLRFRGQPISLVEDVESQPATGTQQYPPDLEANSAAAVPPDGVRCVAASFTCYTGVPRFAAATDTTPRFDAVEFARGTVVTRLRKRLRPYAETASLGRCRDSSDPDEEERFLVPLTGSTPRQAAFALFLMYFNHLGILCNGVRITGEAVASSCVEGLDCGTTTWDLCSKCLYDVRAEVERKRRITRQLREQPEHIFAGGTRWSTTARNRDAVAAAWTALLLSSREALLERIMELNRHIHNLHEEKQRRRHTEEQQSLCRRRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RW85</accession>
    <name>A0A088RW85_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alcohol dehydrogenase 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Alcohol dehydrogenase IV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_302050</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="PLoS Negl. Trop. Dis." volume="10" first="E0004326" last="E0004326">
            <title>The Dynamics of Lateral Gene Transfer in Genus Leishmania - A Route for Adaptation and Species Diversification.</title>
            <authorList>
                <person name="Vikeved E."/>
                <person name="Backlund A."/>
                <person name="Alsmark C."/>
            </authorList>
            <dbReference type="PubMed" id="26730948"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">L967/96</strain>
            <strain evidence="9">MHOM/PA/71/LS94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KM411810">
        <property type="protein sequence ID" value="AKK31255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KM411811">
        <property type="protein sequence ID" value="AKK31256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701228.1">
        <property type="nucleotide sequence ID" value="XM_010702926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RW85"/>
    <dbReference type="GeneID" id="22577258"/>
    <dbReference type="KEGG" id="lpan:LPMP_302050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300024900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_302050"/>
    <dbReference type="eggNOG" id="KOG3857">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="339764at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006113">
        <property type="term" value="P:fermentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08189">
        <property type="entry name" value="Fe-ADH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000003">
        <property type="entry name" value="Alcohol dehydrogenase, iron-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1090.10:FF:000001">
        <property type="entry name" value="Aldehyde-alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF102">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00060">
        <property type="entry name" value="ADH_IRON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="6">
        <location>
            <begin position="23"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="7">
        <location>
            <begin position="201"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00074847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00076695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO00428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKK31255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKK31256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="399" mass="43781" checksum="83E2790390DF1CFE" modified="2014-11-26" version="1">MMCRAYQLTLCATTYLLRWRTPTIIQGAGSLAKLPNLVRGARLQKGLLVTDAVVMRLGLVDSFIDEMNKQSTELVIYKDVLPNPTVDMVEEANALYKTNKCDYIVAVGGGSVIDCAKLIGVRQARPRTALLYTRGLFRVLWPLPPLIAVPTTAGTGSECTIGAVVWDPARNDKFAIMDPFLTPSHCVLDPVLTVTMPKFVTATTGMDALTHVVEAYLNIFHFRTVDKTALSAMELIAKYLPCVYKDGTNLEAREKMLQASYFAGLSFTRAGVGNVHAAAHALGGLYNVPHGYANAVILPHLLNMYGSAAHRSLARLAEAANIPGANDADKAANFIMWVREMNVLMEIPTTFSAGDPRWTLHKKDIPFLAKHAVTEANPLYSVPVIFGEEEMTELFHRIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RW98</accession>
    <name>A0A088RW98_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">UDP-glucose:glycoprotein glucosyltransferase, putative</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_292140</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700818.1">
        <property type="nucleotide sequence ID" value="XM_010702516.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22576977"/>
    <dbReference type="KEGG" id="lpan:LPMP_292140"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290023500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_292140"/>
    <dbReference type="eggNOG" id="KOG1879">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27683at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003980">
        <property type="term" value="F:UDP-glucose:glycoprotein glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06432">
        <property type="entry name" value="GT8_HUGT1_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000283">
        <property type="entry name" value="UDP-glucose:glycoprotein glucosyltransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040497">
        <property type="entry name" value="Glyco_transf_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009448">
        <property type="entry name" value="UDP-g_GGtrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040693">
        <property type="entry name" value="UGGT_TRXL_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040694">
        <property type="entry name" value="UGGT_TRXL_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040692">
        <property type="entry name" value="UGGT_TRXL_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226">
        <property type="entry name" value="UDP-GLUCOSE GLYCOPROTEIN:GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226:SF0">
        <property type="entry name" value="UDP-GLUCOSE:GLYCOPROTEIN GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18404">
        <property type="entry name" value="Glyco_transf_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18400">
        <property type="entry name" value="Thioredoxin_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18401">
        <property type="entry name" value="Thioredoxin_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18402">
        <property type="entry name" value="Thioredoxin_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06427">
        <property type="entry name" value="UDP-g_GGTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839129" evidence="7">
        <location>
            <begin position="42"/>
            <end position="1787"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="8">
        <location>
            <begin position="55"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="9">
        <location>
            <begin position="429"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="10">
        <location>
            <begin position="607"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="domain" description="Glucosyltransferase 24 catalytic" evidence="11">
        <location>
            <begin position="1503"/>
            <end position="1778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1356"/>
            <end position="1376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIO00161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1787" mass="197558" checksum="5DB79C5DBC9DB9B1" modified="2014-11-26" version="1">MSSSMAGTGRGAMASPLRSFFALLRLLVLLSLGITSPTVHGKGIRATVEASWNETSFYQEGCEWAARSFGDEAFYSCLEALWSPPLKGNKSSVNPEEAREAMSARFRTQQQQYMTLLEVLFDLPETRGANRAFFEVEMAARVYSPAVEAHYALTDKALRETTSPQYFSERAYNDEDKRGSGSSSSCGDPFAVVYTRTAPGALLQALRVETPSALKSAVDGVGKSHRGALVSVDEVTFARFDHRYMSSSPSATREVPAVVVLYGFLGSAATHALHRAAVELSSLADAASASTTSAPAYFWRHLPVSVSRLCAAAGVPGRSFSAATTSMWDSPLVVQGYGATVDIKNIEYNVLDEKKAAQQRSKEESLAATATGSLHDATNAAAAAKGAPEAHGGRIVGGFRVARLKERYPGLAALLDEFATLLDEEVGNDDMKVGFDVWELQKIGLAATQYILDVKNHSRRLYVLEDMVMRFPTYATALSRIATQPERLVEVQNTLSILHQTISPGQSALFVDGWRVGEEELSLFGVLHALHEEERLIRCIKTVLTTRAVPAKAEVSSEDVKREVRTVSWLPAMLEKVSGYVKQATRRAISTPENGADMEVAYAIPAKHTIWINNVETSPQLEGLSSELSIFTATDDITQIPRRNVLNYVFLWNPVSKTSLQILSLLFRHRQEGLNARYGLAVVDPTWSPVVETGVQSDARDFKGEPTRSQAALQVFALVYHLAAMDENAVLAFLVELFQTSMKINTDTIPDAVVFRVCKKTAGRLLRTSVAELTSKADFLTYYHETQAVLRRFPVPQYPATFLNGVLLGDDLAGMSAALRRELALLRRWVSSGVLRDEMKDMYNAILKQRNAVDHLQPALVRTPVTMRWSDRPSTVAYVEGMPYVYSAAYAGDALALTQLVTLPCELTTTMLQQVLTVLKSLEECGAVLEEDTVTHEVCRSLRLSLVSCPTATSLVHRHIEALQQQLTRSRAPKVTWHTALRRYVLHVVESVTSTSVDMNAVLCTETVLAALTESPLPDDLQTLVGVSSSTGENTSPQWDREQVHFWTAFEDAYKSSADNVALITNGRIVAMDTSFSTADVLTAARLVAPITKAALHVVMNVNFAEMISAADAGYTAEELDTNFFAGKAACLSSVFVDEISRHVAKESLSAPELMREENMVSSAKSWKRLQGVLFTVRNFRAEGVPSDNAGEAEEESVTASGLQPLHHVTAVVDPSSRDAQVIVSLVHYLVKSQLQVHLTVLLNPSLDVKYPIRNFYQYVASPTLAFEETSGRVIVPPATFTQMPSLTLLTLGIDEPPSWTVFSQDAEVDLDNVMLSRLPRGTLFATAVYRMHSVLITGDATYVQTRVPTNGLPLSLHSSSRAGGAPEAAPTARSTDTQVMANKGGYYQLQANPGLWYLSVKEGPVAAAYCIEAMDGHAVLECAGGGKGLSLTNWSQGQHIPLLVDSFLGRYLSLRVGHTPNSAVAADLHRILQQIASGVEPTWPPFRSTHHTPPERPRKPTLNIFSVASGHLYERFLRMMMYSVHNTSSDKYGANTTRIKFWVIENFLSPQFKRYIPLLAEQLGFEVGFVTYRWPWWLPRQTEKQRKIWAYKILFLDVLFPLDIDRIIFVDADQTVLVDLHELYNMNIGIKPVAMTPFCQKFKNKATASFRFWEQGFWKSHLGLKPYHISAIFLIDLRRFRAMRAGDQYRGTYAQLAGDPNSLQNLDQDLPNYLQNIIPIFSLPEEWLWCETWCSETSKSRANTIDLCNNPLTKVPKLENAKTIIPGWEELDNKLQNLSDSVLASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RX55</accession>
    <name>A0A088RX55_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_282110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700551.1">
        <property type="nucleotide sequence ID" value="XM_010702249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RX55"/>
    <dbReference type="GeneID" id="22576656"/>
    <dbReference type="KEGG" id="lpan:LPMP_282110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000037300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_282110"/>
    <dbReference type="eggNOG" id="ENOG502SSA2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="259573at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="109" mass="12107" checksum="32687CA5FB4AB38B" modified="2014-11-26" version="1">MACATRMCCSVGYYVCLAFICIYLVFCILAVPQYRFVALMIFALMGLCATSAWRLLPSEQIVVRQMAEVMARQCYTSPTVAVPFITSMTTTPAVTVPSSTSHELYRVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXI9</accession>
    <name>A0A088RXI9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside triphosphate hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_290440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIN99994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700937.1">
        <property type="nucleotide sequence ID" value="XM_010702635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXI9"/>
    <dbReference type="GeneID" id="22576808"/>
    <dbReference type="KEGG" id="lpan:LPMP_290440"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000043300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_290440"/>
    <dbReference type="eggNOG" id="ENOG502SK1I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1861185at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033065">
        <property type="term" value="C:Rad51C-XRCC3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071140">
        <property type="term" value="P:resolution of mitotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090656">
        <property type="term" value="P:t-circle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46487">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46487:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="644" mass="67808" checksum="E5785FC2CE0C585A" modified="2014-11-26" version="1">MPAAHVRRDAGGCVPCPLSAVHPCRGGGDEEPEEDPTSDLGNTTTPLDSLYRSTALDVLCDVLTACTCAPALPPSTAKGSGPSSLLPGALLPSGWETRQTHEALEMLVDRVAADLGVSSVRRGHGESPTDLESARSRVSVDSLLLYLTAEGPNLRAALRCHRRQLLPMPPPDSATTHSESGAYASSHAASPEDEALEVLIRYAASVVLANRHLGGNMREGRQVARTPARRVLQTCTALSLLRSTSSFRQPLRAAVGSTDAPQFAMAAVDAPPYWCSTGCLGLDQALGGRGFRSGWVTEVYGEAGAGKTQLALQCLLQQAATDVCHEAVALALANNAGLTPHAHKATVAEMCGSSSPAVKCGETFDRDAVEAARCAVVYLVSEDVPTSRLGPLATAAVGRAVRAVRLHPLLKQLPSCVMETVWSCVESTCTVPIVLSRLQIRHVASVAEVLRLLEPLPHPQLAQPSRITFSTTMARKEAQQPRSTSLVDAVRVLAGSQGHVVLALDSIAAAVVAGQWGMQGEAQADATVAAVGVRLRHAAITHNWCIIVANQVRAVPVTARQCQRALAPIKRARSPTTSATASTSSATRAVVPALGFSWASAPHCRVLLRKSLSHGVRQLVLRHAPSHPPAQVSYLITERGIEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RY60</accession>
    <name>A0A088RY60_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_292680</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700872.1">
        <property type="nucleotide sequence ID" value="XM_010702570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RY60"/>
    <dbReference type="GeneID" id="22577031"/>
    <dbReference type="KEGG" id="lpan:LPMP_292680"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290029300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_292680"/>
    <dbReference type="eggNOG" id="KOG0589">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08215">
        <property type="entry name" value="STKc_Nek"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001074">
        <property type="entry name" value="Putative serine/threonine-protein kinase Nek3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000971">
        <property type="entry name" value="Putative serine/threonine-protein kinase Nek3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="15"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="363"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="409"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIO00215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="517" mass="57516" checksum="D2D7C54C0EAC36A6" modified="2014-11-26" version="1">MSGETAAAQQRMRDYEVFEHIGSGATSDVYRVVNKTNNRSYVLKKMSLANMSDEEQLRAKQEIIVMDNVDHPNVVKFRESFIDEADNSIDIIMEYCEFGTLEDLIDRQRYEGRPFPTDVLLEWMAELLCGLAHIHSTRILHRDLKTSNIFVTSKNHLKLGDFGVCTILSNPHAKAERLIGTPLYFAPEVCNSDPHNERSDVWSLGVVFYEMCTLRRPFEAGNLFTLIQLILESDIKPFGNGVDSSLEGLVRQMLDRDPSRRPTAQELIDVHLEVPVSHPSHPSQKPSRGRLLQQFSGPELLYTKKWPPPEGTATAAEKGGQTRATGEWIHTGSALDVFVQLQRTLHCISTGANAKDGATSAETLQSAANAAPKAPCEAQRQKLQKSAKKTSSKGGEASSISSRRRTRTKASEHTGKQNDDVVVNSSPPRFTMRELRLDVQRRRSAMFGEECSLNIDDVPVVIEMQESFLAEAWWVSRGGRGTFGSQSDSTVAEATTLKETSSLLNVIAAVIDRPGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZZ5</accession>
    <name>A0A088RZZ5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_340560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702483.1">
        <property type="nucleotide sequence ID" value="XM_010704181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZZ5"/>
    <dbReference type="GeneID" id="22578560"/>
    <dbReference type="KEGG" id="lpan:LPMP_340560"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340011000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_340560"/>
    <dbReference type="eggNOG" id="ENOG502SHQI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272841at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="41564" checksum="E057C056420AA297" modified="2014-11-26" version="1">MLPYGTLWKLDQMLHPAGPPQRRTVALRRRQALFLFFWGIFLVSVFLVPFHYAALRRVRIDSERELLGLVVPTVDLEQLHRRQDQAVQRLRAWTTARWTDSHPERSGDDSIGDADVTADFALAFYLHSSSRTRLDGVFAHPYVRALAGGGVGVLWPRLGDAAETPDALQHLSRARTLSEVAVDAAQDASKRAKCLIALRRNLLQVGASDTKSEEKADLINALQATLSKEAELYRIDVGRPFDAGKVAVEAGDWRAATEKVLATLLLWLTNRHTRSHTQEEVISRALAACQAPLSRTLRTSFDWGAIPDVSHATTTIAVAVQEEETAPQYLCLCSQYGVQPPAALVEPSSGTVTPLFLVDPARLEASAQTCADACLRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S006</accession>
    <name>A0A088S006_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Actin-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_340720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702498.1">
        <property type="nucleotide sequence ID" value="XM_010704196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S006"/>
    <dbReference type="GeneID" id="22578576"/>
    <dbReference type="KEGG" id="lpan:LPMP_340720"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340012700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_340720"/>
    <dbReference type="eggNOG" id="KOG0676">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7340501at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="512" mass="53136" checksum="D0663C1197FD7241" modified="2014-11-26" version="1">MQSQQRHYTASSTLCPTLSGADVTSTPVFILDLGSRTIKSGLHTATTPHLTPALAGTPKYPRCLPETSPSSDLSSSISTSRFVVGRDAAARRSLLRLSRPIQHGGVIKDWADARALLLQSIQNALTPPPLSPVARQSLVKEGEEVIYSLVESPFASRQQRARWAELLFESPGQESVVSDGGKQQRVNPRAAGVFCGVGPLLALYATGQTTGLVIDVGDGAVSTAAAVDGYVLPQCLQREADSATGAVVTSYLTRLLYQSGVLGPAAVAPSLFGTTTSNFSNGAGAGTQQERELVYAIKEACCNVSATPLFSTKSSPATAGASAAATPSLDELNSALIAAAQRTQDSRFGGNGAAHAGAPSSRPFTLPDGRVVEVSAADAAQASEVLFYPVLMGSEGRGVVDVALDAVAAAPVELQSQLLGNLVVTGGATCSTGFGCRFFKEMQQRVRGSAVLSTGGTSNQRLCVSAPEQRAYAAWMGASYVAQLSSFASSMVVTRAVYEEEGESALARKLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S017</accession>
    <name>A0A088S017_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_340870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702513.1">
        <property type="nucleotide sequence ID" value="XM_010704211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S017"/>
    <dbReference type="GeneID" id="22578591"/>
    <dbReference type="KEGG" id="lpan:LPMP_340870"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340014400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_340870"/>
    <dbReference type="eggNOG" id="ENOG502S1CT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="259075at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="260" mass="29268" checksum="81FE7C4C7B14ACBA" modified="2014-11-26" version="1">MWRRVGFNRVLATVHPWPDATAPELASCSIAALMASRRSGSGSGSRVCHLQSYLGARPSSVTGIAGPSHVAVSVAASPLTSSVGVMRPTRLLRRPQTIKPNPNEAMSGQFEKSFEKLADKIESRLPFRQHHVLHGNIYEQQYGDRSEHDMWVEAQEDLHGREKEKPAARQARSYFSDEDLSPEALHVRSPQLKVAQNFQRQMYDKKILKTTAEPAAYYYPEVTMEEKRLYRWMLIAGWSAVGVMTLIGLRRLGEYMRTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S066</accession>
    <name>A0A088S066_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Profilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_320530</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the profilin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO00940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701740.1">
        <property type="nucleotide sequence ID" value="XM_010703438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S066"/>
    <dbReference type="GeneID" id="22577794"/>
    <dbReference type="KEGG" id="lpan:LPMP_320530"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320010100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_320530"/>
    <dbReference type="eggNOG" id="KOG1755">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="421374at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00148">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.30:FF:000019">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048278">
        <property type="entry name" value="PFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005455">
        <property type="entry name" value="PFN_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036140">
        <property type="entry name" value="PFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027310">
        <property type="entry name" value="Profilin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604:SF0">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00235">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00392">
        <property type="entry name" value="PROFILIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00392">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55770">
        <property type="entry name" value="Profilin (actin-binding protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00414">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO00940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="150" mass="15885" checksum="A02299AE3F352D8C" modified="2014-11-26" version="1">MSWQAYVDDSLIGSGNMHSAAIIGAADGSYWAYGGSYIPQPEEVKHIQKCLADFSLVQSSGVTIYGVKFFGLQCGTDGDTKHIFFKKGAAGGCIYTTKQAFIVAVYGDPGDTSSLQQALAKNASHAAAVNPADCNTTVKRIADYLVKLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0A8</accession>
    <name>A0A088S0A8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kinetoplastid membrane protein-11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_342070</name>
        <name evidence="8" type="ORF">LPMP_342080</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KMP-11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702633.1">
        <property type="nucleotide sequence ID" value="XM_010704331.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702634.1">
        <property type="nucleotide sequence ID" value="XM_010704332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0A8"/>
    <dbReference type="GeneID" id="22578712"/>
    <dbReference type="GeneID" id="22578713"/>
    <dbReference type="KEGG" id="lpan:LPMP_342070"/>
    <dbReference type="KEGG" id="lpan:LPMP_342080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_342070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_342080"/>
    <dbReference type="eggNOG" id="ENOG502S6FH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="257661at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004132">
        <property type="entry name" value="KMP11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03037">
        <property type="entry name" value="KMP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO01833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO01834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="92" mass="11156" checksum="76376801E25783DF" modified="2014-11-26" version="1">MATTYEEFAAKLDRLDEEFNKKMQEQNAKFFADKPDESTLSPEMKEHYDKFERMIKEHTEKFNKKMHEHSEHFKHKFAELLEQQKAAQYPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0X1</accession>
    <name>A0A088S0X1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_322650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701950.1">
        <property type="nucleotide sequence ID" value="XM_010703648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0X1"/>
    <dbReference type="GeneID" id="22578006"/>
    <dbReference type="KEGG" id="lpan:LPMP_322650"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320032700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_322650"/>
    <dbReference type="eggNOG" id="ENOG502S3DD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273098at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO01150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="665" mass="70988" checksum="879A1E34B58ED80E" modified="2014-11-26" version="1">MVSHGESVAQAPGLQWRGSVGGASVKMITTAVGRLLADYVVQLREDIQSTGMTSDIPSNAGCGVEEGSVVKVEDGGSGFTADSAAATHYMAGSRRTIDTADEAVPLTEADVAEFRQRLQRLQRVKHLLVHFSARTDRRRAHTGVAEVSRLSSGSLATADPEEDDACGVSCETLRQNPVLMIALRRFDRIVQCFQGTAPPVAVVQGQGGGLHEAGTHASVSETSNVCCIQPLLILVPLAEGVLHAFSRNVNIVYRRRPNAAATSAAGKRPRDEASDSAASFSVSTAVAPDPLNYWDLLATQQRKRRFALYTSRSALLPRVNAVCAPLYVSPAVQELAQLNSEAERFMLRRAWCVHTKAHLLREVPWVARDVAAYRVALREALQSFTESQQDAFLSGVVYVEFVCAEDGIVRVCVQHGLFLDLTYDVRRRQWVLIELHWNLFTTSAGASLVTSKTALAVPHAQAPPVPPAAPTTAALAPSIAHGSVHGPAESTSPLSDASAPASFVQVVPHDREALRNFLKVAFAQEGLSGGLHAANRLVCAVVLDTFATQLRSLQESFFTGGGLGTLVEAEVRPGTQISLHISLPELFVSSAPVAHVKMTMVGGTVLLECVRGTDLSTRQVTLPLSTSSLVVSAAPGTSTAARGPLMPMVDMEAFLWKCVCAFAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S146</accession>
    <name>A0A088S146_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CFAP410 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_343150</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702741.1">
        <property type="nucleotide sequence ID" value="XM_010704439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S146"/>
    <dbReference type="GeneID" id="22578820"/>
    <dbReference type="KEGG" id="lpan:LPMP_343150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340037900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_343150"/>
    <dbReference type="eggNOG" id="KOG2123">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1517790at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055004">
        <property type="entry name" value="CFAP410_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849">
        <property type="entry name" value="LEUCINE RICH REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849:SF18">
        <property type="entry name" value="LEUCINE-RICH REPEAT PROTEIN (LRRP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22800">
        <property type="entry name" value="CFAP410_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CFAP410 C-terminal" evidence="4">
        <location>
            <begin position="267"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="189"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO01941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="303" mass="32709" checksum="76A3C999A13BEFDF" modified="2014-11-26" version="1">MAGVLTLNLVLQKSKTDDIRRVRKLNVCASQIQDIGVLRQAVALEVLSMSLNDISELGALSNCHRLTEIHLRKNQICDINQVLHLSRLSSLEVLNLSDNPISRDPNYRRFVVAAIPSLERFDDRDITDEERDSALAVFPQLLSFAPPPSRYAQPMEGIAPPTIQERQAHAQASRMYARSSSATMFAAGQPDVHHRQAASSASGGGGVGGYNGRGDSAAGSNPPIRRAPPASVHQDPQYGAAPTPARSSPVPRAQAVNDYRTVSSFLPGPSEEGVVQAVKVLCSELSPEGLDDVRHFIDSLSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1D1</accession>
    <name>A0A088S1D1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein-tyrosine phosphatase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_030460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009372">
        <property type="protein sequence ID" value="AIN95281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700989.1">
        <property type="nucleotide sequence ID" value="XM_010702687.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22571912"/>
    <dbReference type="KEGG" id="lpan:LPMP_030460"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_030009100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_030460"/>
    <dbReference type="eggNOG" id="ENOG502SE2N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267921at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF10">
        <property type="entry name" value="OS12G0136300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="605"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="647"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="764"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="818"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="965"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1050"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1173"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1270"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1500"/>
            <end position="1524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1595"/>
            <end position="1618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1905"/>
            <end position="1939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="672"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="823"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="967"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="984"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="995"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1173"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1272"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1595"/>
            <end position="1605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1607"/>
            <end position="1618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1915"/>
            <end position="1937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2287" mass="239651" checksum="ABB4D66ABCBFAFD8" modified="2014-11-26" version="1">MNEEEVDAEAQQEGLSVKFLDKNKTEAAAAAVGASSTGTLQPAQADQRSDASNIMPKMEASAGDQQAKERTRQSTAATATGVAPDPRSPPPTLARVTNVMVVGTSAALSTVPLTWSQYLFRGAGGGVRAVAGAQRGGAAPVQGASSTLPHSQSDGALAREPKTTAGSPAGLTAAPQSSVSSSIFHAQYLPSLEEFQRKLEEHKHRQHLRQQQQQQQQPPTLSATRLQQHLQQQQQQQPSQSRHRCRRAATNKTFFYSPTPSVISLATTAATTTVNANPEHEYSEEEQQQQRQLSYSGATATSPRSPPVLTAARGNSAAAFSGVWSLSSSPPSPPSSSPASQTRRHIHQSHHLLDGNRIPLRRCTSSTSSLDHLGGDDEEAEPGVGATAVISQMLYSTPHSSRPSPSQPPHPSVMMRRAADRLCASIMHSSARTKSPLLLLRTHDVGTNRGSRASSGAAAREDGGGNERGEEDEEWTSSRHGTSGSGGGVWPSSSCPASPTVSISAMSFSRVWSRTVSGRATPRTTLATGVGSGCSYASPYSTTKGGRNARRRRKAMCTRRRRTMRVYMPSITEGPKAASLYTAPTAEAQELLLLLQHRAASSSLTSGVTGRSMGGHGASTTSTVFSMPSSPRTYSMVAGARVPALPAATTSTTPPVLQPSGVAARPRPSTFAEAARARCGSGSGSSNGTSAGVVASRQQQQQRSLASSSVTPSMAPRSPGEAERTPHFLTPSHSRCALTPPAPALIAGTSFTRLPSPQAIVSEADSSTVRAADGSPASAVQEQHPHPPRPTPLLSAPRAFHCSLSPLVLGAGSEEVHPFGGSAASSPQSHEAATDSSSASWSGVVPAPPPEAAAVPTSRSFTPAGSSGGGEAGDVGNQAGVAGRADVPRDIRTDRSAEAHHLQSSTPVSSAGPATPVELPQWVRERPLSALYYQPWGLELLARYEAARHDQQLMRARIARRVRPGVGSNTTAATSAVSEVGVSGNENKPPSSAASMHNSSVTSLSSMSSPSAPISSSYMTSTTAATTAAQHAPVLSRSSLGTSRGGCAHTVIATGAGGPSPTPSPSTPSISWAAALRQPQRTYLTCSSNNSSGGGFGLTTATTEASKITATTTMNNCTTTTTTTTATAAVTLLQQHPLRRPPAVVPEWPPELSAAEERDAWEEAYYFGRVAAPSSPSLPQSQPQRHQLPASHSTTKLLSRMLQDTKLGQAEGENASTTADLAGCMAGSSGQVGGRVSSSRVPSTAAASAAVLMRQQWWLNKEIQPPTLYLSRQRRTSRRRSRAAYPSDTFRSSAARRAGATSAAAELFHKRKDAHLRATIDATAVAPTCVEAVGEAAPVSNAAVDPPAGSSSTFTSSAARGDLTLYNDSYPRKKAAQLFYPVASLHSGGTPPLPPAPPHFFDSDHRTLSQGAGTSRAAAALLPVSALGDTDAIERGGDIADAQQQQEVEEEGIEVGSSAAGGQITIETSAALQKGNAVEQVVENDGAELDAAGIGFGWRPPNRLSTDDPHRTGSDLVSGVESDAAASRPRDDVDVIFFLQKFIRAALIVFIVQVRLRQLQKQRERELQADSLHSATCPAGAYQLDPQAQGQWMRLKGRHGGHPSRGKPPAAAAAAEGSEEGGLSKLERCALSFVRRYMADYRHMITAYVMRDDREVARRSAQAIFSPPRSAASALSMLLSSADTLTGTTPGATDRTFSPTPDPLFQQDVLTRCLNAARVTTAYEEAVRAATCDLPCSADENPPATPLDDVESLRTAQVYISGKDAAWQPLLMELLQVSRIVQCYSDGLAVTAPAASVTTPQQLLLENLEKFLAQPTLPLLRHAGPDPAVTAQALATTLARPAAASTGTITAASSSLASDMRTTTTPSLTPVQEAAAALMVEESDAFRNYLLSGYLRNKAAGDSTASAATTETTTLRHSQSAPTLSARATQPRQQPLLSSAAAMPSCPVTCAMSQQPESPSPLFSTRSLLQPLVWYPYAHMPGTANPYAEGTDPSTTHITPAQAATASSMTLYVTMLPLSGKLLWRWVVPAEDTDNFNLSVFFQSSLFSFMQGGPLPMPSAAPAPGEWTAAATAAAAAVGAAGFVPTPMTVFTAPPPSPHPSLTWPPALAARIDAQLRSDAFISAWGEVPPPCMCGAAATVDGTSHRLCAGGWGELPEVTLVHCSAGMHRSCGILIAFLLWLLYQCRQVLRTEQTLALHPLSGTRAPAHPLHAGAEAADDAALKALLLDGRDALAPAEASASDMDASWMTSCLLQRAIRHVHQQRSIAVPIRTVQCLLQSFANELQLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1R9</accession>
    <name>A0A088S1R9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit L</fullName>
            <shortName evidence="4">eIF3l</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_350240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit L family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702964.1">
        <property type="nucleotide sequence ID" value="XM_010704662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1R9"/>
    <dbReference type="GeneID" id="22579053"/>
    <dbReference type="KEGG" id="lpan:LPMP_350240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350007500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_350240"/>
    <dbReference type="eggNOG" id="KOG3677">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="15082at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03011">
        <property type="entry name" value="eIF3l"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019382">
        <property type="entry name" value="eIF3l"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10255">
        <property type="entry name" value="Paf67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="472"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="479"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="509"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="524"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO02164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="539" mass="62293" checksum="3F483C03B380802E" modified="2014-11-26" version="1">MATNPDIETDIPRDVYQFFRGLNRAVERRDAAAMHELYESQFDALTKNYYMAGHGQFRSWPALRLEQVSSCFRGNRMAELVYSFLFYKHLFMDNRSVRAPDAEGAWRTYSDLFPLLKSYELPNWMLWDIFDEFLYQMTVVYQKVFASEGTWAVPEVSRLLNEVVDNSRLFELMKEPDFLDDIHRGPNTGALSGFYAIVTKSKLNVLLGDYYSALTDLEPLDVYNKGRAVLSRVSPCAVSVFYHIGFSYLMIHRFEDASNAFRRCVTVKLNGRRFSERVQQDAAYMYVCARVLGGMPISNLTSYLDSRKVAAFEDDRESLRTGDEERFRDVFDRCSPKFLTVPPSDGLPVKGSEGRELQARMFRRAVQQQQDIIKLRGYFKVYQNTKMNLLETLLEVDDGYAPLFALKMRSRQLVHDGVTADLLQGVFTSSSEFDCIVQDDNVEVVPSMTFGGIEQKLLNKIKNTQRDIEMAKRKFNQARNREEGGNRRKENREQKRRPNQQLLHGGAGNANRNSNNTNHPRQRVTAQPMTSNLFNRNDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1T1</accession>
    <name>A0A088S1T1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin-protein ligase, putative</fullName>
            <ecNumber evidence="6">6.3.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_345220</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.2.-" evidence="6"/>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702941.1">
        <property type="nucleotide sequence ID" value="XM_010704639.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22579027"/>
    <dbReference type="KEGG" id="lpan:LPMP_345220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340060500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_345220"/>
    <dbReference type="eggNOG" id="KOG1426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="258495at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042469">
        <property type="entry name" value="HECTD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46654">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46654:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="4">
        <location>
            <begin position="1742"/>
            <end position="1947"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="5">
        <location>
            <begin position="6299"/>
            <end position="6618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="34"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="2">
        <location>
            <position position="6586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO02141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="6628" mass="735802" checksum="CF32033C78165392" modified="2014-11-26" version="1">[encoded data, 6628 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S245</accession>
    <name>A0A088S245_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Enoyl-CoA hydratase/isomerase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_353360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703273.1">
        <property type="nucleotide sequence ID" value="XM_010704971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S245"/>
    <dbReference type="GeneID" id="22579365"/>
    <dbReference type="KEGG" id="lpan:LPMP_353360"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350041400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_353360"/>
    <dbReference type="eggNOG" id="ENOG502QR73">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410701at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF100">
        <property type="entry name" value="ENOYL-COA HYDRATASE_ISOMERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="3">
        <location>
            <begin position="343"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="3">
        <location>
            <begin position="731"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1141"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="334"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1148"/>
            <end position="1169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO02473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1169" mass="131545" checksum="A2821E6722807933" modified="2014-11-26" version="1">MLGRRVCVVPSLAVGPAAASSSATPVSADSQQRRSIKTLDVREYRPLGTPIEFRFYQRYANHPNRQSGVQFLTHYNTHQRFRVNKDFIDYMHWGKEQGQARLPHRHQRVAFDFDDSLQPTRAEGDTSHWFAGQDPTMGPHPDISTSFDPNKKLFSHPEHWNKMFSKRRPGEGDIKLDVIPSNSLLGPMVTQTDTQEMAYFKTETRGPTHGCVPGINAPFKGEMDCKMMQAMSRPLSSSRTLTGNDGRFSKTIFINDPKRHQALSAVLAKELNREVDKATNGLYSKLTVLTSAQSGLTDFFCGGADLQSIGFDLTMAQLLRKEAEELSKWDASGCKKVEAKVQELLRDAERYEERADAVLRENAAVIWRAYTSPRPLMTLVNGKCRGTGCGLALAAKYAGLQDASEFIVDGPNVGLTPYSGMTRLLARPETSLKYPGLAEFVMLTGASLFAGDALRLGWSDLFTSLPDMPYHIKDWFDSTEHMHNDAVAWQLGHLLEKCFQMKDRSHTGAMERCAMTPIRARWVEDAFADQPSIEEILKTLSAMEKLALTDRHNTCDPSYATPYTLVSVAEGVEKLRASQLRYTLSPWDVTPPVETVEVRQAAEIFTSYVLERRGKVNIVTHRDRQKVEAWRKQREHEYAMYSNVKSAPHRRHVYARLEGCEGTLVDFDFTINPASNVAATSATKGASMGSNDEVLHTASVDRLKRAILQAMSMPADRDVDLCWYLPTLDTCPIRNDEELVDVLHSDPGLEDPSAQLRYPPIYFLVKRNTLHLSEWAYAVKHQLLLQSPYALKATLQLLQEVRGDGSAEAMRSLADTLATEYRYATRLLKRPDFYEVGQHVDKSPEEWDVVKEERARNVHKAHLPTRPLPDYEVVFERHVQLDGHTFQLRPRWSPRTVQEVTAESLAPLASPLDFEKDNAVEFNVVVHTSKADRLAGMIDDAGGFEVVANLGEVDKEGNPKVPPLQGDAHVPTNVNFYEMARHPWEDTPSSWRRDGFTAGSKEYFEQQYKKAEKAVYDEAGREQYNYWPSKDAVDGVAGEELNALLEERFFAKLRDAELGVESWARQLRQKAVEGKLDNRTEIATQQEKIYDDEYYRWFIQPGHNPNPSGLLRGRKGADSGSNSVDKDLEVFLNQLLSETAARGADGATSEEGEEAVLPEEDVDEAADGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2F4</accession>
    <name>A0A088S2F4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Multifunctional cyclin-dependent kinase pho85-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_352640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703201.1">
        <property type="nucleotide sequence ID" value="XM_010704899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2F4"/>
    <dbReference type="GeneID" id="22579293"/>
    <dbReference type="KEGG" id="lpan:LPMP_352640"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350033500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_352640"/>
    <dbReference type="eggNOG" id="KOG2421">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1058301at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08572">
        <property type="entry name" value="GDPD_GDE5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051578">
        <property type="entry name" value="GDPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE PHOSPHODIESTERASE GPCPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="3">
        <location>
            <begin position="601"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="384"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="994"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="421"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1001"/>
            <end position="1017"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO02401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1017" mass="111788" checksum="E8F32D9042E14D19" modified="2014-11-26" version="1">MTLMNVCVYGLSSQMLEAFFVRECARSAHPLVASSASELRFGLVAAGESMGAWGMAWPVALEWCQCQRTPCINVPYLSYHPHHCEGGRQSSVEHYVAQVRFTSQEMNRLRDQQSDAEHLSMPCRLVILEEAFLRASCAPESSICVAPGTVIAGVDQRYSQPSSLCITPFEPKKNVLMECDGEAPQWLAVLDVRQCHDGSDIEDGDPLGCIGRNGAATAPVCFGSTGEQFAFLYNLPALPRRTFAPVLKTVSSGMNFLASEEDADVRVGSPNGSIPPFCECLPDSGKRAAADTPGPLLSLTFYANDPTQPFDQAAWESRLTSHQSEVMRRRMRETTDGVPSTTVCHVTDVRPVPVEGSCWCRSHLPMPVPSKRQLRQVHMKRVAAAASGNVDQDNYSTASPPGSSTSSVSTISSPHSGCYHSHVESSRRSARDGETRPSAGFLAKGWCVRPLQTIKPVLPLTGLADSSGRAPLMAARTQHAWTCLLNLHELEEFAIEVTVKVPYVADGTVLSLQGNTVLFSGMLHSSTSGTVLLPVYCPAPAGAPEGVASLWMKLYVQYLLTFPLEGCGQRGPLEIVRSLESLAWLTVSTLIGHRGLGKTYTRSSSPRRGAPLVIKCSENTIPSFQAAHARKCNMIEFDVMLSEDRVPVVIHDPLIELMALKREGVRACPDKAEYTSVRAAVHRLNYTRLRGLHVQCCKPLDRVFATKDLLVQHWDTLIAWARNCQPKLLKGSSSSQNSVCNCSSVRTVESSVMRMEDFPNGVPSLREVLEQTPPSLSFNIEVKYPFQPLVDSNLFLQSDAFEVNGFVDEILRVVFEFSDDGRNIVFSSFDPNVCLALALKQSRYDVFFLSDTKEMRDLKDYRSFYVEGAIQFAAAQHLAGVSMNAGTLLSPEDEVVLPNIPEVPLHGSAERGPVIADLFHADDPQHAPPTVPPSFGAYGRAMIAEMHHRNLKVWTWGDMNSYLYFAYVQATKMRVDGVIGDRMPVLPSLKQCGQHSTLDMKPSDEERVEMEKLGSDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2G6</accession>
    <name>A0A088S2G6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transportin2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_352790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703216.1">
        <property type="nucleotide sequence ID" value="XM_010704914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2G6"/>
    <dbReference type="GeneID" id="22579308"/>
    <dbReference type="KEGG" id="lpan:LPMP_352790"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350034700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_352790"/>
    <dbReference type="eggNOG" id="KOG2023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="951172at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:002073">
        <property type="entry name" value="Transportin2-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="6">
        <location>
            <begin position="29"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO02416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="938" mass="102518" checksum="D14F23B3837D24D2" modified="2014-11-26" version="1">MYTPTEGDLVNVIQLLHNNGVEVSNSKAAYTQLKQYESNPAFCILLSAVFGADENPVAGMVLPVCWAQYRQLAGITLKNNLTSVRHALGEDAVKEAARFALKSLANPPDTRIARTSAQVVVKVTALTSLEWWMSSGVGDLPNILLNDLLPGGDLKTIAALYCLQYLMEDVPKQIGESSGQIILRVSQLAVSQCAPVTIRKAAFRMCFNIYEQSSLLDWNVDTLSPLQVGLSKASQSLSSVCTSLLECSCCEDPAFMILVLRTCSLLLDYFDFFTQISPSEMQRYTNWWITNSAQLIRNSQNSINGNQELVAAAIGLISTTVDLYDRNGGETGVAFLVSGVSQLIFSLAPALVRYALLSAEEVASIMDTDDYRIRDSTAVSFEVNGGTKDISEDNMMDDDAAAMTLRSSALKLVDVLSTFSSDATYQAFIGPIQQLWSSSEWREREAGIVLVGTIANGCAHELSAVLDSLVEQFLQFISNPCEHVCVVSIAEWSLSRLSETVLNSSPCTMDRIIPLLSSRLKSTSKRIQITSVSALNVIYGALENNGSTSMVMPHLPSLLESACACLSVYSTTNLSLLVDFLSKLIGLLGDRSTAERLSALLQDERTKRASLFEQSYTAMYIREEPNVLLDKDIFSLDRAMIAFISIYPSNEVAIRNLSTWSDVLADIKSRNVTDDADLIFNTLLICSAYTNSVSTAILEEWLRSTLWGLPVSAAHFLTNSRTREVKVAGITVLCGLLHVVGSAALPTGLHDTLMRWGTSEVSEAEDPQLKEHLVRLIGKTTSCYPGQLSAVATEALKAANAALRSDVFGDSAYYFSAMAFDLCSVLGAIPNCAAFFRIDTLSQLMAQAENTMDKSEATIHLFQALVQLPADIFSGVFSSTIKIVYSWQQAAVHYPGTKEAIQSFLFHARKTCPSMFQSILEGLPAAFRNMLVSFYQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2J2</accession>
    <name>A0A088S2J2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_353420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703279.1">
        <property type="nucleotide sequence ID" value="XM_010704977.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22579371"/>
    <dbReference type="KEGG" id="lpan:LPMP_353420"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350042100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_353420"/>
    <dbReference type="eggNOG" id="KOG1893">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="303066at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071260">
        <property type="term" value="P:cellular response to mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050982">
        <property type="term" value="P:detection of mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027272">
        <property type="entry name" value="Piezo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031334">
        <property type="entry name" value="Piezo_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056770">
        <property type="entry name" value="Piezo_THU9_anchor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13167">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13167:SF25">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12166">
        <property type="entry name" value="Piezo_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24874">
        <property type="entry name" value="Piezo_THU9_anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="385"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="621"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="647"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="673"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="773"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="797"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="827"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="888"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="963"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1037"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1081"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1104"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1133"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1290"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1315"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1346"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1645"/>
            <end position="1671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1683"/>
            <end position="1703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1857"/>
            <end position="1876"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1896"/>
            <end position="1913"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1925"/>
            <end position="1944"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1956"/>
            <end position="1975"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1987"/>
            <end position="2006"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2067"/>
            <end position="2088"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo THU9 and anchor" evidence="4">
        <location>
            <begin position="1856"/>
            <end position="2089"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo non-specific cation channel cap" evidence="3">
        <location>
            <begin position="2139"/>
            <end position="2480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1492"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2505"/>
            <end position="2538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1559"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2506"/>
            <end position="2523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO02479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2538" mass="277630" checksum="CC494EBAF9705ECF" modified="2014-11-26" version="1">MTSLSVIVTDGGPESISPRHVAALHALFLVLATISTITLRAPVWLIGALFYCSRHRRALVGRRLFPSPLWQTLLALLVTSTICNVAANVLTTLQRNTTWVQKIVWQFLFPVWALLGVQQWDARDYVNTMVCPGATTVVLGTYLLILRHTLSGRVLSRSDGTRMAQDRSMLRRLLSRWEGTRIATCRLTTRSLLFLFSWVTAWTAEPSVIGLCLEGLTFVFAAVFLHVEHHIRQPSHCAVRNGPGAKRHVPHIFGTAVAVVLVFVCATQNTAFLSATQAHSDWCRLLGIGPAALDTVAGLRYAMQMLGMAGVFLGATAMHHDMASSESPIPESSAGTATSADGVTSRLLPVGNQRLLRTPVSDAPLPSMAAHDGGLCSRQRSIPQVVAIVCLTAILGYAVYYPSLVSTAMWLLHLCCCAGGLVQRPLAPPSALRIALACVLAVLCCMIFLQYVYRMLAGNPRTAAWGQWPPAKPAYPDDGRAVGTQVVAEHLIALLCGVYVTVAGVDDTGGSSIVSSTSEGAVPAAQSSSPVNRMVLSAHAEAHPADSVQVTWLRAQLRDAAANRRKLRELFGVAVGRSPRTVELDAICAAAVQELDGSSPAASRGGLTAQEVTHLLASGPFYTYAVILCMFVLGTSSATIDFLHATCLVVSLGVSVIGSNAVLYRRVRTVPPVWVAIVVGVQLCYSVFTVKDEKRPQQQQQQRWLISAVAQPSFIKLSLGGYAGLAPIAWGDCAPYLYAQLVLLWCSRYTPKWLTDWTHISQCLIFRCRWARFLHIVHQVAGVVVLAWIALLLPRSASVTVLILLLFAAALLQHLRCHKLAYVWRRFLVVGYCGVVLMSMLTAEFAPVQPWLWKLLHALGCPPGSEGRCAQDIGLPADSATWLTPLSIPWWLVIVLATATTSLYPLPSSLPPSPDAASATGVPEASTARCWRALVLWPQVLSDVLSLALLVSMVHTAVQRPRILVALYLVGPGLGIFPCWTFGLAAVHAALQCAYQLWFSPAWLDTQTRLGLSPAELIGLWRPSFAMGSAENLPPTLVVAAAPLLVGAVQSLQLQCALQARWRARNMEAAVSGPGRMWSRLRRTCATHLYLLLLWVLLYLAQKIALGWLVGLLVVVVWVSAEVRDCGVLQRRRWLYGACASVTAALMALAYVLHWLHAVFPSWSALAMYPWLLGGAANGGKTGIGLRSVCCTAAAACAVLRVSSGAPRDGESEQLFRHSHGPSFIDWLRGRFRRSCENREGPAASLSQVLPDEAHEFFRDVADVFRCAEEIAEEADVLLLAPSQVPPSKGSVVVSVARLVPLVACGSIAVGSAKTSPPCVLSVALLLAGLCLAMRHAHLHWSFWRWWRLTVILYALLPLIALVAACPCVRDVIPTLPAWVGLLIGLSQDASHVDSDALVFSHWQVMLFSLLWLQSCVYNCPGWCAALLRQHDEERRLGETRHAALQRQLLSYMARAAEEAVRVDREIRSCLDALRAGDNIVDASLLRTRRGAEYGREEDGDERGDDTERVRVSIPSPPPRTPVAETEELDGVLGGTGTWSRPSLLLSGAGGRSDAAATSPPSSHQPQPSRSLWWRQQCVRWLRRLSNQLAAYTYHPSEYRLSVAASSAATADSSVATLWQLGQRTVLTAVQVVLRHTPLGLLGCLLVNSLLTGCLWELIGLCYVVQVALAYHPYAPRVVYKAFGVYLIAGVLLKEAVTIWTFFDNTDSFIITVLSWTLLPLKGQGHRSSNSNQLRTTMPSSRGALRYDTLWMDVVTMGVLVLHDRMCIIHGVYVEQKQGSREHDSTRIVVVQEGLASSAEDAPPSTTATAATTALPGVVSLLFPTLSHATSSNNAFRAFVVDYCNNLLAVPGIGEDWYIFYTSVDFLALIVVAVFYSRIAGNDNATLQDNVQNNLLPGPMALLLCMSVLQLVMDRMLYVQRCMRLKALANGVCAISYTLLYWWWRNAVAVSGHAAGNTYFVIKVVGLVLSVTQVCHGFPVHRCHHISAAHLGSLVSYSSFMVYRSLPFLWEVRTLVDWTVLRTSLTLQEYLTVEDIYVYIYRCRNRYLAKHRNGEKLADAVPPTSKWAFGVSYLALVLLALLGPLLYYSTYNPSTAANSATLLNFQLSFFGAYDFFSTTVHDNVTTPEGWWTWIERTRPTLGAYRVMTAEKTVQLMEFTSCSSSLWMASPQAIRQVLASLRAAASNESSAYILQTLEISRNVSGTATAAVVSLANHWSIPWGTAQDLVDILEQETSGTRTATVVDAQNDSSGSIVIASASLPFFYSPFAFNRASRIDGLPTNLRFPHRNQHNCTLELNHDKDVALNSLVRYWCLHCAPLFPEGNVPSKNVSDAAEWRCLTTGEGCDDFNYEDVADGSGNRTMRTPLAAHMNTKVAEAQVPMYMVVISDTVVMGISFLKGIGIVALYTTLVLALGRLLRSVLANQASTLLYSNMANPAVLENMVRWIEMAREYGDLKLEHTIYLEFVDLLRSAERLFRVTGSLRCMYTDTGDENLFRLGQVRRRDSRRNPSLDVHEGAAGEGHGDSAVSTAVPHPKRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2Q8</accession>
    <name>A0A088S2Q8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_353700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703306.1">
        <property type="nucleotide sequence ID" value="XM_010705004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2Q8"/>
    <dbReference type="GeneID" id="22579398"/>
    <dbReference type="KEGG" id="lpan:LPMP_353700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350045100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_353700"/>
    <dbReference type="eggNOG" id="ENOG502S3KD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="29"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="103" mass="11724" checksum="FAD51B98C370D94D" modified="2014-11-26" version="1">MQRSLIPGHNNNRHLAYEEVENNIGGLPVTDNRIQELFDSLDVNHSGAVPVEVVKNFYVGLEHYGLNLSEKEIDETVRKHAATHDDTLTYEEFACFVLSLAQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2T3</accession>
    <name>A0A088S2T3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chaperone protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_070850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009376">
        <property type="protein sequence ID" value="AIN95771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704093.1">
        <property type="nucleotide sequence ID" value="XM_010705791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2T3"/>
    <dbReference type="GeneID" id="22572420"/>
    <dbReference type="KEGG" id="lpan:LPMP_070850"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_070013900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_070850"/>
    <dbReference type="eggNOG" id="ENOG502RYUV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="32"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="380"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN95771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="439" mass="48926" checksum="7C7134C080311E1E" modified="2014-11-26" version="1">MASGGPFAAAAWYMARRHASTGRRPTFAEIAEALDVLEVSIDVDPKALKRKYRELVKKNHPDAGGEEATMARVTVAYERLSALTNREREEFKLQKTFRGGGASSAASRRYRPGPPGGFGYAAPNGPFQSQTVNMYGQYYPQDANTAYHQAHSSKGQQGYWNHFHSRSGSGGFANNPFTTNNPFSMYAQAQRARFSSSSSLLIQGLVVYLVLSTIFLFVYRSYRDWRHDDGWRMSESLARHEQMQEIHRIRQEMNERARTMQQRDDDYAAAAPYGGRQYVGESPKDRAFEYARQRRIQMMQERPEAAANLPELRGWPKIGEEKGRIIKRAQDPSGIVFFEPCKADTRRRQVEVRRRNNDFVSCSPSESPPTQLCGAAQGGPPSDAAAATAAISSSLPAHSSVSLPPESNVSSIVMKPVSGEEEAQAVMHRIFGGLRKISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S345</accession>
    <name>A0A088S345_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone deacetylase</fullName>
            <ecNumber evidence="3">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_080880</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone deacetylase family. HD type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="3"/>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="AIN95896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704218.1">
        <property type="nucleotide sequence ID" value="XM_010705916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S345"/>
    <dbReference type="GeneID" id="22572550"/>
    <dbReference type="KEGG" id="lpan:LPMP_080880"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_080011600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_080880"/>
    <dbReference type="eggNOG" id="KOG1343">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="424012at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09992">
        <property type="entry name" value="HDAC_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF5">
        <property type="entry name" value="HISTONE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="10">
        <location>
            <begin position="209"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN95896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="615" mass="67036" checksum="FD564B367A7EB33D" modified="2014-11-26" version="1">MCVAYRASPMPPSRFARHESSGTVIVRRFQFPHHETEAHIRKGHLREPLEAVASRVGLRARCSTGPSFADLCLVDDQELLLMGKLVDRGVYYITGGTCTDVEGDASPRSTKSTILNSATCGVAPQPPDITVGWCFDARMLLHRSEINRSPETPHRLQRAIETLQACERACDILPVELLAPFRVHIDGTLEPNLGRVAPSISAANRAQWIPARLATYDEVCSFQDPRVYHDFLKSGASLVSLKSDVYCSDEASSVAARLSAAAVIDASVAALRGVAATRSGGTSSAAGCVLPLVSFCLVRPPGHHCAASQPSGFCLVNNVAIAAQQLRTRHASVLPSGPPRIAILDLDVHFGEGTASFVEGACDPTSLLYLSLHRYDKKSFYPFDSRGDTSYVGGSRHTASKGSICNVAVHTNAQHPTQCEQVISDHLMNSVLEEIFLRRLAQFRPDLIMVSLGFDAAYGDPLGKMAVEGGFASVLSRLKEWCLHEGRSVGLVVALEGGYNPEAVAQGVLSVALALSLPRTDPLLQQLLVERPPKVWADLRQRQERRHREWQNLRRERAEEGIGGVLIGQSSEMKPPASEEPEKPQEDALLLDRHRRWCAALVAKVQQIHRDAMAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3P3</accession>
    <name>A0A088S3P3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SET domain protein, putative</fullName>
            <ecNumber evidence="6">2.1.1.354</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_350200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.354" evidence="6"/>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702960.1">
        <property type="nucleotide sequence ID" value="XM_010704658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3P3"/>
    <dbReference type="GeneID" id="22579049"/>
    <dbReference type="KEGG" id="lpan:LPMP_350200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350007000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_350200"/>
    <dbReference type="eggNOG" id="ENOG502QS33">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5792673at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053201">
        <property type="entry name" value="Flavunoidine_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12350">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12350:SF19">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="4">
        <location>
            <begin position="304"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="5">
        <location>
            <begin position="430"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO02160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="473" mass="51707" checksum="2C39DC62D04FCE99" modified="2014-11-26" version="1">MPISRNVAVVHDIATTPEQLDAFKRACPNSCNFFPVKDAVQLQCVVQQIYAASPSTYGAVVNLCADGSGGANGGITSALATLLLHHASLPYTGCRATTLNHPFDILLMMLFYAEVPLPPFAIVDSVEAARRAAHRLKAPVQIRNTCRLFGLYDECCTMQGDVEATLVRTFHEHGKIVAWEVNASKERAVRVLVAGGSVKGAAAAIPLESCAAAPSWAAHAEEVARRYGAAVSRYVLYDCGVASLTLNTLKEEPGKWCFEDIVLNPAIAHLMVQEAVPNLLSEAPSTAELVASLLAEAQKCHPSPTFEIKLHADSRKGYHLCAAKTLRKGDVVFEDECRSFAMVTRPYVEQHWDDPLKKRFTEYAWPLDSEGHLYAIWEEDPQRWRPVNHSCDPNCIFAAPHSLNVIAAREIAAGEDLSMDYATFCDGTMKPFRCLCGADCCRGLITPDAASLIKYGEHSWLRKVPSAVKPLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3V0</accession>
    <name>A0A088S3V0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA editing complex protein MP61</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_351080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703045.1">
        <property type="nucleotide sequence ID" value="XM_010704743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3V0"/>
    <dbReference type="GeneID" id="22579137"/>
    <dbReference type="KEGG" id="lpan:LPMP_351080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350016400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_351080"/>
    <dbReference type="eggNOG" id="ENOG502QT77">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000021">
        <property type="entry name" value="RNA editing complex protein MP67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39671">
        <property type="entry name" value="COMPLEX PROTEIN NUCLEASE, PUTATIVE KREPB1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39671:SF3">
        <property type="entry name" value="RNA EDITING COMPLEX PROTEIN MP61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="1">
        <location>
            <begin position="239"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="598" mass="66655" checksum="110F66B84A119B2A" modified="2014-11-26" version="1">MSCCSLNRALSQWLPSGVIAGHVRRTPGGAGSPHLPRLTHVTSSSSVALHVAAASIGSSGSSIIRSSGKKASVYYNFATPVDVFRDGADGGSVCHRRQRREALGREGGPLLVAPRTPDPGDPLQRLNIFRRDFSDYSVSARGSQNIMVSVDTTTRRFLDMFCDFDAKRCKLCNETFTQWHVHTNGIPHAGREGMLLELVRPYCGTPEELIEMWWQRLNSCAAFHRIPALSHNNPHERKRRLLYLLKLLKDRGILVETFNVSDSQSINSARSWEFERLEFVGDNVVKYILNSVISCTFPPHEGGAKGKLTCFQFVMDGNDGLARGYDHLDLQQLASSVRVVSKFKSDIVETLFAELQMYLWSTQHDVGTSPLVFPFTRDIYTLRALVQHVLYELAIELFLYHISYINGMLQRVMRENHLQFVKTDAALNPTTGANIRSWGMKASHGDWTDRGEDHSLPQGYGAPAMPAPTVTLMKVRSQRAHRQGSDAALFFESTNYDNFKRVVPIGGLLPRAFAREELSVIPNYMPHLQSDGTMTLKMRKAGNAGWSTLYASAAAVVERGVVADGLGISATMKPRVDREPVRLSVPRLKDEELIPELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S4F6</accession>
    <name>A0A088S4F6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_353740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703310.1">
        <property type="nucleotide sequence ID" value="XM_010705008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S4F6"/>
    <dbReference type="GeneID" id="22579402"/>
    <dbReference type="KEGG" id="lpan:LPMP_353740"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350045500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_353740"/>
    <dbReference type="eggNOG" id="ENOG502RPF1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="274786at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO02510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="198" mass="22720" checksum="9B5A3D59083D74C6" modified="2014-11-26" version="1">MLKSTCPKRAVFHNAPSVYPFAKPFHDTPYDQDRGRFDKTKNILRENKWPAWMDHGADGTGFGIGLNRTHPLSKLRGNLRRNPSEIPRVLNMMIQGVWHKSGNKLYFRGGKPPNPSTHPYLTGEPCPVYGWKVTDPGVIREFNLPQPERDKTRYKPYVALQERKIMGMQAPIKGQSAVPTSTESTDSKPLMKRLFFWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S5W4</accession>
    <name>A0A088S5W4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dihydroorotase, putative</fullName>
            <ecNumber evidence="6">3.5.2.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_160570</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="6"/>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN96931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697584.1">
        <property type="nucleotide sequence ID" value="XM_010699282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S5W4"/>
    <dbReference type="GeneID" id="22573634"/>
    <dbReference type="KEGG" id="lpan:LPMP_160570"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_160570"/>
    <dbReference type="eggNOG" id="KOG0370">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="434at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004038">
        <property type="term" value="F:allantoinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050138">
        <property type="entry name" value="DHOase/Allantoinase_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024403">
        <property type="entry name" value="DHOase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668:SF2">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12890">
        <property type="entry name" value="DHOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroorotase catalytic" evidence="5">
        <location>
            <begin position="14"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN96931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="405" mass="44191" checksum="32B3E52AF8E69043" modified="2014-11-26" version="1">MSSVPSSAPAVIQLPPLIDCHVHFREPGLEHKANIATESTAAYHGGITSVCDMPNTIPPTQSIAALADKVARAKATAHTHCHLFFFFGATAEAHLQELEELWTNPAHAELKTHCCGLKLYLDNSTGNMKSSQPVVEKSFETCGRLQIVLVTHCEESQINEAAAAQHPYDGPASHSLRRPAESEVASVQEAIALARNYRTPLHLAHVSTAQSLDLVRQARAADPTLHLTCEVTPHHLFLTTGDYSCCGARLKVNPPIRPPQHHEALWAGLLDGTVDCISTDHAPHTIAEKDHCGAAAQPPSGMPGIEVVVPLLLTVVAGQWPHPTAPKPSTLAAAEQQGRPLVVDDVVRLLHTNPNRIFQLRQPHTPDRIFDLDCEWTVHGKDLHSRCQWSPYEGWRLRGRAIANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S5Z2</accession>
    <name>A0A088S5Z2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Flagellar calcium-binding protein EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_160870</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN96961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697614.1">
        <property type="nucleotide sequence ID" value="XM_010699312.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22573665"/>
    <dbReference type="KEGG" id="lpan:LPMP_160870"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160013000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_160870"/>
    <dbReference type="eggNOG" id="ENOG502S6CU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272063at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054322">
        <property type="entry name" value="FCABP_EF-hand"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22592">
        <property type="entry name" value="FCaBP_EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Flagellar calcium-binding protein EF-hand" evidence="9">
        <location>
            <begin position="1381"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1158"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1505"/>
            <end position="1534"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="352"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1506"/>
            <end position="1518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN96961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1657" mass="185629" checksum="93999940B68BFAC2" modified="2014-11-26" version="1">MGCTSSSLSFRDVYIDLQQRWGLDPKLYGVLEPNGVSERSSVFASRASDAARQASQEFLLRDGRLFTCDSLLVEQASLLKYFLFPSEGKDTPHPYNAVLFRRLLSVVSAEHARHAATEVFSIIREGSFISRWDYRVWMVACCEFYHVLAVLQEQKALPKSTKAFMKALAQLSEQSALLQQSTEGTVLFQDTLEEVWREGSAVQLTSSMLEGLAMEQLHSQMLSVLAYTPKSTSTSTATSSDDSLAPRLIALATEYEKRVVPMTERQSSNPLCSCDIASVRSSVSLLVFAEWAAMECALSFCGPEEDFASYGVAPVPLSSVLLQPKNSLRQQWRTRLLHLSEVKCELAELEPLGHLSEAYGELLAKKEALEREMEKQVERWRGNCEALSAEDVEGMCWGLLEVRESLPNRTVHQILSRKAFEHTSGVGSTISTTSQLCNYLRHYLALHDLYCDVLIRQLKRSDLEGLDDESCLPRPTDFDTFRIVLVAAQARHDTCLDPLLGSAAGCGPLRAALTLDIMRRLFNSVAENDMEDGVRGVSFDALCAMVVRGLAQGRHVSLSLRSIDELRSAVGIDQTKQRHAFIESFLREVFTLNQEDLSACGPLLAAKALEGVVGLPQYTDHSACVAAMVVRYASLEPRCWCALSASDEVELAAVTRWLYRLRSESLDRLSLMENSTCMEFAVRTLFCVAAAQRGFEDTAPRAEKSVNSDISFGDVQLSATRPLMTTGVTQVHFVRAMAAICKYLECPADVLLNNSNALLLPTSSATDVLATLTMSPQFTVESAFRSFQGVPHSAVDCHGYDDGEVEQRNAPDRTPTARVRQILFVIVFNYTRQHCFMDWRTHTQYADGSVTSSAAEDGSSGDYPKWEGESTLLALSHAMPLQTLVGCYRVFAQLTEREAQRNGPAESARGRQSLFLHALYTRYMLFFQQLHLDEDHVAEVGARALQFIVSQSGCGTCDHGELGITRRGFSSFLQFILGYLMTEKAYESAVEANTGVRGVAQDGTVEVFLSEQDCLNLLAYFGRLTKGGISAIPTLEEAQLWLRSHCFENTYKGFISLQNMCLWYGSYRAEHYALESLYDWWRESYAQRIPFTTSTEHRCERQSTMREILRLKQHREHLSESYPVEASEDEDGFLPVEITSAVLERRWGVREVTTRVFGMDEESTAGATPPGDRGEAQASSSSSSVPLWLDSCECGSNAALHRTDPGSRKVHRSDFRFFLQYMHHFVSAYISLYYVLAVLEASSGAVSSDGSVHRVPSTPVEYQEKMTELLSQSLLPLLPLIAMPAEMSSTLSSVVTDLWHDMQTTGIVPDVTCRRGAHSIAAFLVSHSHLLSYRVRQSYLEGIEAQDIHEMLNTQGALLGEMDSYDTSAKLSYWECLRVLLPFGPSLHQRQRRRELFMWMDRRQRGYLTMSDIARGLMDRVQLQSFRADFSAALLRAFRATKDVAAERQNVIYLTQHTEEQVLMPWEFNAFLAYLYRYLELYFMFDVLTCGGHVHPETLHVVQKQQRYDTADPDEGRSGGESVGARRNKRADGAEDAAVAADGVAVTLHTRSAAVDLYEASTRPYQITLEAGLMKKEVSLAQFRIARQLLRQWGAHVENPVEVFEHVDRRCHEEGKMLFNGFAIWASEHDLHPAANDYGYVDSVDAIAIMEEDCAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S6J5</accession>
    <name>A0A088S6J5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase, alpha/beta fold family-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_170980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697789.1">
        <property type="nucleotide sequence ID" value="XM_010699487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S6J5"/>
    <dbReference type="GeneID" id="22573841"/>
    <dbReference type="KEGG" id="lpan:LPMP_170980"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170016100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_170980"/>
    <dbReference type="eggNOG" id="KOG4178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19657at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF7">
        <property type="entry name" value="ALPHA_BETA FOLD FAMILY, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="58"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="360" mass="39703" checksum="DABB8F59A48ECE4E" modified="2014-11-26" version="1">MTATLTAELDAAAGLPKELHGKAQPLPLDKFARVGKCASTGKEITLCYRTLGNPDNPCLLLVMGLGGTLLNWKNEFVQRLLQAGFFVVQYDNRDTGLSTHLDGYTIPAIARMILPAWASIGEGIPPYTLYDMGRDAWGLLTALGIQSVHVLGTSMGGMIAQCMALQHPERVKSLTIFYTHSSGPHVKPQTWQMSFAMMEKPSGPSFEEQVNFMVHINSLFRGDYPHDEQEARSIAAANLTRCPVDNDGVMRQIWAVRRAESRENDLRRLKGVPTLIVHGMKDTMIPFENGVQLARLIRESRLVAFAHMGHSIPRELYRDIVEEIKLQKALGEEAKAQTERSSSGTGATDSITPTEDTVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S7M9</accession>
    <name>A0A088S7M9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_201040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698303.1">
        <property type="nucleotide sequence ID" value="XM_010700001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S7M9"/>
    <dbReference type="GeneID" id="22574311"/>
    <dbReference type="KEGG" id="lpan:LPMP_201040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200014900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201040"/>
    <dbReference type="eggNOG" id="ENOG502S374">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="194"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN97596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="231" mass="23841" checksum="B66C7DECE95EFA05" modified="2014-11-26" version="1">MGNLKQRLSAFFPQLTTKEYKFLVEDPSGSTGGCGAASGAVRTCSAARHGGIGAARSSSSGGEAAPIDGSFSGEGGTSGAGGPYTNGTRAGLDVDQLWDLINSFQQLQRSLGGGQVGPTEGHNTPSSGAAPTTAFNTSLDAYLVGSQGNAGARAGEGGFDAVAEAFRIYDPRNSHYVEEDILSCIMARVGFGDLSKEELAVLVSTADFDGDGRISLEDFRHLVCMKGRFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S830</accession>
    <name>A0A088S830_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Phospholipid-transporting ATPase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_202350</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698438.1">
        <property type="nucleotide sequence ID" value="XM_010700136.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22574444"/>
    <dbReference type="KEGG" id="lpan:LPMP_202350"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200028900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_202350"/>
    <dbReference type="eggNOG" id="KOG0206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0210">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF19">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="486"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1285"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1326"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1350"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1391"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="8">
        <location>
            <begin position="23"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="9">
        <location>
            <begin position="1173"/>
            <end position="1417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN97731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1510" mass="167931" checksum="BED9104501BACB2F" modified="2014-11-26" version="1">MRARVRQLFAKSAKDHSCQERTIQLNDPRGRTDFCDNRMYSSRYNLFTFLPLNLWEQFHRPINIYFLLVAVLQFIPSVAPVSPLTTIFPITVAFLVNAMKEGIDDLRRHRQDAEVNERVYQRVRSGTLELEEVVSANIRVGDVLILHPFEVVPSDVVILLTSHDDGSAYITTESLDGETGSKQRFAILHHMFKYSQTAASPVPSMSRCCRPTSESTTAPGSDVAGVGASAAKAMGKSAQGPIWEGKCCCETTEDHKLHCLRYALCSRLVLHSEGPNAQLHSYHGTAKVRAPRSSSQTWGKIQPLALGPGSSAGDAVRTGGTALEALQSCRYDPFPASAALRISSDSPCADKAVMGDAFPCPPPAPMMSPLPFRLRATRTLESPIEASSPCIAYEHSGLLESVDLSQASAPLRQSSGEVKADAQNYFDVPEKTLSVCIDNVVYSSSRIGNTHFTIAFVVFTGCETKMSMTRNVRLTKCATIDLRFNYLTMIVFLVQFILVLTCAVISYWRPKAHAPLWYLGDSVDPIKFRECFPLLSLRYLMMLSPMVPLSFKVMVEISKVYVSYVIRWDDDMRAEDESVSVNNSALAEELGQVEYIFSDKTGTLTTNTMTFHALALVNDAVFARTEGTIGSDLHHPLAEVGKAIKARMARGQQEDYYLMLTMIFCNTIEQTLSPRLGTRSSGVSTNASMSFSSRWMSSSPDEVALVEGAEQCGFYLRHRSRTHGSVGLWGEAGASLEVEVVLTLPFSSDRGMMSVLLRYPAVAVMNPEAKLNDSADTAGESNADSSMNYVLLIKGADEKVLPRCTDTHSSSHLKEIMNHLARFSREGLRTLVYGYRILTEEQVREALHHFTAVKESFAATATREAELQHIYARLERDFTYCGITAVKDELQEGVPQTLVQLRHANIRVWMLTGDKTETAKQTAVACGLLATADHVVTLTPSSENLLTPTGHLAYVSAKLSEVMGPMDQEKSAAEMTVVTRWERVRGWCRRFFWESSGLEDFVHEFTQPATYECIRPVDHPLATQLRSAIQAHYGPVSPRVRDMAPRVCGAACRQPGMYFGSAFTISSLPNTCGLKRRYCVVLSGETLRLLEKEDVISHGQSATVRLFQMCLLQANTVVCSRTTPSLKSYMVNLVRRSGHITLAIGDGGNDVPMLQAAHVGVGVKGREGSQAKLASDFAIGQFRFLSKLILVHGHTAYQRTAMIVQQSFWKTVLIAWVQVLFNVSTDFSGVSYWDSLSLTLYNAIPTVPVTFLCVMNMPLSQWLLCSTPKLYTMSQRGRYLNATTFYGYVARALLHGSMVYYLSVALQHGAGAIMAKGWVLDRSGDFYAPYIAVVTVHTYTVLTESHSITIAHWFCFLFSIWTCFLSFWLYARVPASSNRTFSVLLTSPSFYLVYFGLLTAVCISLAIYAIPKALWFPDALQLERLLLAHLRQRRVWHSSTPVRALRTFFQEDNPSQFWKSVSLYHALRCSPPPRQTFTISEDEDGEAEASLISVTRRIRSPHVRKRAGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SA20</accession>
    <name>A0A088SA20_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNase III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_230400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699198.1">
        <property type="nucleotide sequence ID" value="XM_010700896.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22575244"/>
    <dbReference type="KEGG" id="lpan:LPMP_230400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230009400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_230400"/>
    <dbReference type="eggNOG" id="ENOG502SMK8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416741at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040545">
        <property type="entry name" value="DICER_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040715">
        <property type="entry name" value="KptA_kDICER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040562">
        <property type="entry name" value="PPL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18176">
        <property type="entry name" value="KptA_kDCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18177">
        <property type="entry name" value="La_HTH_kDCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18188">
        <property type="entry name" value="PPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="2">
        <location>
            <begin position="1050"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="893"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1114"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1644"/>
            <end position="1684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="904"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1663"/>
            <end position="1672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2215" mass="245552" checksum="70E0022EBDFC5410" modified="2014-11-26" version="1">MKRNDCGGSTVEDVFIECISEAALRVVSPQIIMQAVKLWLTQQSVFKSINPEGFFAQPDTFGWSAAPEFLRYWVPLVAQKFNKFAASEYAFLHPPSHVGTGCLTSKTATLLSLDHLQNTFHQQLQDLASTGAMLPWQWTYKEAALEIFLALIFVLIYHSQPAIAVRAVEPVFLSILTHKDENFMAMPQLLSYFLPHTSFQGIPFEERVAIVADQLILRGFQFSVALTYADTVAAAAGRVEMCSTELVPMSVREVVQRVRDISSAFNTASVHIRSFIKRIDGETSEVEGLTLSKYISLVLQECRGFYLRCRQASKCRIQWGEALQELQPVDVCLVMRRLKKMLRFGSPYYEHFVRKGVWAHILCSDGWVPLQLIEEELAADTTTPVAKLPSKEKLKIVESLLCQHDNFQRFEVGYCLLRRSPFNGQRCARSLYAHEIRNPLLYRQIICQRERLVQPDDATAVSNLPLFGWVALPQHPSKALGVHPSLFPLFDNIPFIVAMPAEAIGVFRDYEERTPKAKKYDEKLRKPHLWFAEVYLRAIARDGQVMTGEADGGPASSPLSSSVMATRSTSLSSIISATSWAVEEGSHDCDTAQSATCTEVYTRVGSTSNPATQRWYVFPQYYVKWLIKAMAKSSPSHCKATDTTATATDELSSQPATGQCDDLTVYRQDVGRYPGVLGLPKLFFTGRIAELRESTSTEIRCHAASHDGEGTAKVGAARRTVAGACGAEKAGAKSLEHNDAAPECSDAVDEGRDKNWNREKLQARQGPHRRRGTPQEFCATVEDIDCSNGVALATADSATCGEEEEMKRQTVLWKYTIATYHASSSLLPSVVVRMCCRDTAATDATTMIGLSSMEVASAYYCRCFPPSRVQSIFTDYVAEIMAEVIVGTENDKKDAQHNGATAAAHQQKNGRLNNKVSTLPPRNKELELLPSASYTAAASEGEFAEKVFNVASLLKTLNAFIASNELSCVVSVRVRTAAGLSLNQCRQGINKLKAFARGMGLQYVLLAKCSSRGTAASDCGRNAGGSDHEEVLDVEQYEFRKRVTWSVRELEHILHELHLQSIDIPAATLAKALTRQCEDKSFNYELLEFIGDAVMDFLVVSDACLLSNAARQRGISSDTPSAPTPLSPRTAAPQGKWEPTAWPLPLPQYCWLDAGVPLSSVMENTVNATVCRNIVIAELLPPTASRHFNDKHYPHLTFKVRADVFEAILGAAYRSGLGLDRIRVLLRRLFSFLPAAARMARAAHSESANALSQALLSCPYLLEDDALRVEQLFSYRITQLFEQAPRLLEGAVSSDNAGARETRFSTHLASSTLPRIQGKVFASMFTTGSPMYSYRRLHFLDTARLHNRILHLFSERSIGYVNEIITNITHLVLDLDKVSPHSWGLLSIIWDWYQQYYRCPAAAFALDSSGVSVVNGKWKDSCHVHFPQVTVSIDTWASLVEHIRAAVVIHLAEKEARLRNFLVAHTADYRIWLHRKALVQAVHAAGGQPRPHMWDYCDAASLLVLSCTSRAVRLSIFEHVAYVSQTLPGLASFAEVSSCADVFYGDWKENEDMVVLERHRGAPWHRLIVPLQWAKLYFAASSSSETAPVVYKPEDFWKEAIDEGLIKSKKLRLYLNDKCDIKYGTEKRPLVLDTLLVVSSHKEHLKQQRRAKRESSSPPADLIKGERKKKEAGGAVTVPETHTRPAGAVADWLRRWPNEGAVQYHPQRHNQPLMQTTKASCTRRSRLDDTRKEVQRRIRCVQHERAVESGAVPRCASPPSSPPQRWIQPIKWDYEGPYDDPAEGWVVECAHSSTLTLSSLRTCEYRGTDQKMYTSWVDCAPVTDPVHGEQAAPPAPLFAKEGTNDILASFEDVYEHRVDLPDRLKCTSWSTWINACVLRAPHTPFKAGSKVNAWSPAWWDFDPQHSVTTLYVATEPILRLTGTDSLAAALAPPSTVCGGGGMERFAQLFIPQISYANVPPVKLSTATYGPNVFPLFPDMSVKRIEAPAERSANKAVKFPGVAEMGSTSSAPPSVPAAVACGTWSRDFFSPVPKIVALPATLQVPAAAAATLASADPTASPALGWVGRAIQYVFSATAARLEFGRLPLVVCESNSVYDRVQAEMCTSGAARPHPSLLFVLSLQDMKGVRFFVKTMCSDGNRGLQALRHIFVVVDSDINSAAVTPASVALMGRLQTLWNILRLSAVTHTNECPLLYVSSDAIREQWHRALNPLRQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SBN0</accession>
    <name>A0A088SBN0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">mRNA 5'-phosphatase</fullName>
            <ecNumber evidence="7">3.6.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CET1</name>
        <name evidence="11" type="ORF">LPMP_252180</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67004"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
            <dbReference type="EC" id="3.6.1.74"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:67005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fungal TPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.74" evidence="7"/>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699788.1">
        <property type="nucleotide sequence ID" value="XM_010701486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SBN0"/>
    <dbReference type="GeneID" id="22575866"/>
    <dbReference type="KEGG" id="lpan:LPMP_252180"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250024000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_252180"/>
    <dbReference type="eggNOG" id="ENOG502S89T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272147at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140818">
        <property type="term" value="F:mRNA 5'-triphosphate monophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004651">
        <property type="term" value="F:polynucleotide 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07470">
        <property type="entry name" value="CYTH-like_mRNA_RTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.10">
        <property type="entry name" value="mRNA triphosphatase Cet1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040343">
        <property type="entry name" value="Cet1/Ctl1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004206">
        <property type="entry name" value="mRNA_triPase_Cet1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037009">
        <property type="entry name" value="mRNA_triPase_Cet1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118:SF1">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE CTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02940">
        <property type="entry name" value="mRNA_triPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="mRNA triphosphatase Cet1-like" evidence="10">
        <location>
            <begin position="85"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN99081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="312" mass="33724" checksum="4899184744FB49DD" modified="2014-11-26" version="1">MSTSRTPPPQEAADVSASAIPTAPASQKAAAVELEAPASAPVAAETSTEEAASSSPGHDEAPPNPPPLLEVAESLLARLKPFLRESHIEIEARICSIIQSKKRTHSMMKGHVGATATTISSHDAPHIVEGEHRRIQVGVSAEDFARMKAYMAEKPEALPFQESVTEDVNTRTGRYTYAIANDGSESFIGCIEKRRLCNVEVRVPGCPYDIRVSVSTEVPKPAMDAPAVKPHGCVRRKRRWTATEKTFEYAFTRVSTVDHKYPVFEVEVEGIHVSCQAGVTKAWLADLLGRLVALAQLKGNTGLPHRLACDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SBY4</accession>
    <name>A0A088SBY4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulator of chromosome condensation, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_260720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699893.1">
        <property type="nucleotide sequence ID" value="XM_010701591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SBY4"/>
    <dbReference type="GeneID" id="22575975"/>
    <dbReference type="KEGG" id="lpan:LPMP_260720"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260012000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_260720"/>
    <dbReference type="eggNOG" id="KOG1426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="34"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="273"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="325"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="471"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="533"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="589"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="657"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="707"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="843" mass="90169" checksum="C385D1A7566407E5" modified="2014-11-26" version="1">MQPVMETAGALYTNMENASSATRKLVERYISGDGVIVGWGFCRNGELGTNFRYNLVTPMMIGGHDKPIRMACGGLSSVWLGVRSILMAMGGGMWGELGVGNPRFCPRVIANEANMPICPGQVDVIPFTQDDVVVDVAAGSAFYACVSLKGSVFTWGANNCGQCHPDLNNTCCGYGQLRIVPGEKVVEVVCSNYSVLARSMSGAVYGWGEVTLLGDRDAVAEKLAAAGVKLVHSPQSESRVVARVPVCISSLDDKNIKLLSSGPWHYAAVSEDGSVYTWGVGNSGRLGHGDQDDHLVPKVVTAMKGKRVVDVACGSFHTIFVADNGDAYACGDNQGGQCGVVGEYSVPVPTKINITGGRKAIHASCGRLHTTLLLNNGDVVVYGTGLGLGVGIGYGMRMVRCQAILENYTTLWTKSGPTHGLSLTIPKNTTMFVLGVPHRGVPVSVTSIGLKEGILSCGVGAGFTLMISRRGSCYSFGVGGWGQLGFDTAQARHFTQDRVPVYPQATRIGFFSRTIITSVAAGFSFSMAITEGERVFAWGNNSFAQCGLGVDPKKYQRISQPREITWLADKEIVQVSCGSYFALALSVSGQVYSWGTIECCGVGLEPDPKVVPAHMIMRDVSGETRGVVLSPLLIDNLKGIIHVAAGGWHGMALNAIGEIYAWGVGTGGRLGTGDCEHCYTPVRITHGAFFTRIGCGCYTSYGIDDRARLYVWGVNAKNQLGMLDGKVMTPTLVLENVREACLGKYYSLALTHSNTFHLSGVMEFGSTSYTSTSFDDTDSLPEKLKPENIQSENLRGLKLFGGLEHVIVLLEKDPIPEAVITETVMGLREQPERLVRKYAAQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SCL1</accession>
    <name>A0A088SCL1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_270640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700153.1">
        <property type="nucleotide sequence ID" value="XM_010701851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SCL1"/>
    <dbReference type="GeneID" id="22576240"/>
    <dbReference type="KEGG" id="lpan:LPMP_270640"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270013200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_270640"/>
    <dbReference type="eggNOG" id="ENOG502RZ0T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268819at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="19537" checksum="139CA776C61DC0DF" modified="2014-11-26" version="1">MKVELTLQYLDEWMLRWRKFQTESDWQIENNRQWWRQANMVTAGAVMGSLVMYTSGAATLRRQFGAPHFFDVGVDAKIKEAICDTMTSRWRYTPQGYGRLMLVGLPTFFVFAIAEHIQERRRLRAYVNQNTVFGEQARRLVQSGKVEEYLAVDIKASLPQSQMQLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SDP2</accession>
    <name>A0A088SDP2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Translation initiation factor EIF-2B subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_282430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700583.1">
        <property type="nucleotide sequence ID" value="XM_010702281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SDP2"/>
    <dbReference type="GeneID" id="22576688"/>
    <dbReference type="KEGG" id="lpan:LPMP_282430"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280030500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_282430"/>
    <dbReference type="eggNOG" id="KOG1461">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="424572at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051956">
        <property type="entry name" value="eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056818">
        <property type="entry name" value="GlmU/GlgC-like_hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24894">
        <property type="entry name" value="Hexapep_GlmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-1-phosphate adenylyltransferase/Bifunctional protein GlmU-like C-terminal hexapeptide" evidence="2">
        <location>
            <begin position="417"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="764"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="764"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="813" mass="87984" checksum="C365982470B42930" modified="2014-11-26" version="1">MDIAAVRRGVAGRGDRQGPKLIAVIIGEALLPTLLRGGHVTFVGPLSPLSPSPRLPAALLPVCNTPVIDYVLENLVLNGVDEVTILLNSCSAAQTIAHLSECRTARGKPWMLSDSIDVRVIECARRIATLADAADEMRERNVVPQNGSFLLVPIDTVASFTNLRECYQTHLERVRKVSKYAATLLCVSSRPALAAALRNSLVNHLAETEEASSQSPVSPIGDSGRHGVLSIQQTSDMLRLRNYPAPVLPRERHTMFVFNKATQVVTYMARLESGEEAPEPPAVVFSSSAPQSVRMDLLPTGYLFCCCEALSLIEFHIRDLYSFLSTSLLGQVEIYGNVFGLIELPASSSVVESISSAEAYIQCNLDVCARRLFPMTRESCFAEALAKYAVSSTCETVYLHTTSKCANNSLMGPNVVVGEEVSVPASVELAGTVLGARVELGDEASLRSCVVMEGARIGRRCMLQGCLIGPHAVIGEGAELSYAVVGERCVLDGVTTNGTPLVVQHQAIECDAEDTIGADSDSAEGHKTDKVLTGASGRGHVLEDRYSSNILPTSALFTEDPVARPAQSGDEDDSSEEDDEQAVFRRSIQRHVQAALLQPSRIESSSYDMSTVCLSSGFGYPELCEIVTELLMEHLLGAHRDESPADMVEAARDLFHTWCRPFYNNFLSKNQQPNVDAMVATLEGLCGAIGEVSCPLRCYGPQLVEMLYYGCDDDLYNERGYCIVSGESLIAFDAEMEHRLQVLQRYTAFNGGRDKSRGVAGLLSSDYDTTSSSTSSSSSGDDESRDLHEEGKVLVAVSCHCFIMGVKDFLDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SDV2</accession>
    <name>A0A088SDV2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_283040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700643.1">
        <property type="nucleotide sequence ID" value="XM_010702341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SDV2"/>
    <dbReference type="GeneID" id="22576749"/>
    <dbReference type="KEGG" id="lpan:LPMP_283040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280037300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_283040"/>
    <dbReference type="eggNOG" id="ENOG502SBHZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272860at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="407" mass="45254" checksum="AA76F32AA330B71E" modified="2014-11-26" version="1">MSLAVNSTAPIPEPPYEVKGASTMDDLAVLIQREYTQQYTEARHQYKASHARFTARAKRPPLSWLDQYCRDAFHDLSFYTSAPNAEEACAPSACTHGVRRIGLHLLNYELRLLAQERLRTTPVKPKRGADDVVTLLVAQEAAEYAHLLKLEAASFMGVARAYYKEIFGPTNEVLWLEAQARRSFEDEYSHTTMAFLAQLREELWGAQQRLFLRAMGMYPAALPHVAQLRLMAAESYALEQAKLAVLDSREAVPLWHRVGAIRGETESEEAITFRRISLAYVVGTHSISDGYLRRNTATGRLQRTYKEVPAFMQDAIDYTMQFEAFAVVLEEEAHRMQIAEEAENTCASLIAAVASVADTEGDVSSPLSLLPPLQLRATPGSQRQGSDGVQRVPATGTESHHNGGRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SEK2</accession>
    <name>A0A088SEK2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein kinase, putative</fullName>
            <ecNumber evidence="6">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_292500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="6"/>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700854.1">
        <property type="nucleotide sequence ID" value="XM_010702552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SEK2"/>
    <dbReference type="GeneID" id="22577013"/>
    <dbReference type="KEGG" id="lpan:LPMP_292500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290027300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_292500"/>
    <dbReference type="eggNOG" id="KOG0192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF103">
        <property type="entry name" value="KINASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="164"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO00197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="447" mass="50402" checksum="24D7118C12B521D0" modified="2014-11-26" version="1">MSWHKCSMCQSRLQDNELNFCISCRVAVCGTCTQICYPNRMSVALCMRCAVPDYVFSCGRCHQHISYEGLEFFCDMCANPICFSCVASGTSFECGKLKCSLCCEYPMSQAARNLVIRYVVDDAMLRQLPMPLVSRAAPVAPSPPQARVTAAALVATMSTKYRNLLGREKLGEGAQGVVYKCRTEENEVVVVKEMVFNKTDVTAFEAQARQVERMRQLNHPHLIRYLDVSVKQDPLRICVVMPFYNEGDLKKFIEMQRKPVTEVKLCSIVLQIAGALSYLHRQEPPLVHRDIKPENILLLNHKEQVLLMDLDLCRAVDVTASVIKRREMSPTYEYRAPELATSCGDTKADVFSLGVVMFVLATLPDFPCVRTDSGEALVLSSSEWSPSSLERAIQREIKGVQGYTYSREFIRLVVAMLLHKPAARPTSESVIHRLQKIMEQRLMEGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SES1</accession>
    <name>A0A088SES1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LMBR1-like membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_300570</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LIMR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701092.1">
        <property type="nucleotide sequence ID" value="XM_010702790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SES1"/>
    <dbReference type="GeneID" id="22577111"/>
    <dbReference type="KEGG" id="lpan:LPMP_300570"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300011000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_300570"/>
    <dbReference type="eggNOG" id="KOG2296">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="203099at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051584">
        <property type="entry name" value="GPCR-associated_LMBR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006876">
        <property type="entry name" value="LMBR1-like_membr_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21355">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR-ASSOCIATED PROTEIN LMBRD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21355:SF0">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR-ASSOCIATED PROTEIN LMBRD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04791">
        <property type="entry name" value="LMBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="464"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="540"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="556"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO00292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="609" mass="68517" checksum="F6046979D5F2F1CB" modified="2014-11-26" version="1">MSSGYVAVTVIFFVLAFGVCLLVYRYYTKESIKRMPIACAVWHVIALYVCMLPFPLLVVDVDASLAAQNDPSQKQNWMRPIWITIFAVTYFCAWVSLPLAQMYTEVGEFTVKGRLLHSIKMNLILYAVIIAIILVALCYFVIITDSYRSVSNVMKVVISLANAWGLLILTLFMPAGLVGVPRMLWRYADAKRLLCSQLYEATDIQENLDFAAMDLAAIKAELISIDPQVSEEDRPHLAFMLELISAADREIPMYHMAALRVKAVPSADRNDVSLLHLETLNQRLKKAIKIVNRANYRWNSTVRKCGSLDQIVRGVKGTNNPLKRMWFPIRQYVYYTCCFVCSVLTIFILWSELTMPLRDWAGKPLGVIELMMKSSIHFIGSVVLLFYMAYCAYWAAFQFKVHDVYVIYPSIADNASLCFNETFLVRLLMPLCFNFLLISGLSSTANETRVDVAYGHVYRSNMDIGLLFGSYVNKLLPLMIPFLAATVFFQLTQQMLSIVGIEVHNPNDVENPAVRQRIIDGRKLVEAELGYQLTSPFLPGEGVDEVKSPSVPPRAARPDRDGAAESDAKRGQRYREYLQKKRGGTAGGADGGSEMMNFGSAGSAREEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SHB2</accession>
    <name>A0A088SHB2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FG-GAP repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_323070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701992.1">
        <property type="nucleotide sequence ID" value="XM_010703690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SHB2"/>
    <dbReference type="GeneID" id="22578048"/>
    <dbReference type="KEGG" id="lpan:LPMP_323070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320037100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_323070"/>
    <dbReference type="eggNOG" id="ENOG502QPN1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270568at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34284">
        <property type="entry name" value="FG-GAP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34284:SF1">
        <property type="entry name" value="FG-GAP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="675"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="727" mass="81006" checksum="7C3490D6620731C4" modified="2014-11-26" version="1">MRIRDIIIIGVAFVCIIICWSQEGSLNFQRGFMIPIVDNKFTETIMPKPILVDPDGSGSRILLSSTTVGYLNIYNTQYARRRIDDNFVRLSLSTELNVYAPIVGIGAGYTELNSSIVLCAIVTEDYQLIAISIHTSPPSVLWKSQLVAQRYWTDLTHASISIVPERSWTEDVGMIAVAVKVVDTSGVEMMMYSAFDAKTGARRWGYFSDGGNEMDDVVREANSEMTQADGRAPELRLLTHEGEGKDGANLHDYLQGRKYEQPWTTFRESVMAAMPHRYAHVWDAQLYPHVFYRAKAKRKARPSRGKAKRRATFRYNDQVVHMATEDDGNLGDKLSALRLSLKQPTQTSLAENATRQRRRLSNVFVFHGEQGVEVVHMYTGNIVTNVMPLRADGTYYDDINDDLVLESLSTQIGPRSIVFAKRGIDLSYDCLGMIETGVPLSADELFNATVCNTQGLFGNLDLIHHFVDGDIRGEEAPRALNTLELLGSRNVASAMTRATPPLILQVQQNMGGGLQQVERYAAFMIDTGLVTCIDPSRRRVLWRAQTGGRFAPSPSDDMAEARKIRYQVNSDVRPFPQMVPYSLLQKNRETDVTFVGGGGESFRRVDTYVLAMGDTEFSIIKTKNGKVTRSISLSEPPVAPVLVVDFNGDGTNDLIVVSKYHIFGFVGSSRASSETMAALMLLLVGLLGILFAVREKKIAEEGQDDYTLPVHTGDKVQRKKTFKRSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SIE1</accession>
    <name>A0A088SIE1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_333020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702392.1">
        <property type="nucleotide sequence ID" value="XM_010704090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SIE1"/>
    <dbReference type="GeneID" id="22578455"/>
    <dbReference type="KEGG" id="lpan:LPMP_333020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330038000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_333020"/>
    <dbReference type="OrthoDB" id="263829at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO01592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="277" mass="30108" checksum="86165E3B3FD872C1" modified="2014-11-26" version="1">MIRPHKRPACDKTCAIVLGCVLSGFALIAFILLWRCLAAKRQREKRLRMENDACCKGYLYASHEEVGTNENSAEVPVSTMVEKDILPNPFSANTRSSASPLDSWNPNSHINNPLDGVSAADSSGRGSVVEQVLSSCIPIAEDQVVAFPQEQPTCLAPQVEAPQVEAPQVEAPQVEAPQVEAPQVEAPQVEAPQVEAPQVEAPQVEAPQVEAPQVEAPQVEAPQVEAPQLNDVAQEEEDLQAIKSNRRPRMRRRNHLRGVSAAACPEDNVIDILDNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SIM2</accession>
    <name>A0A088SIM2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_340140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702442.1">
        <property type="nucleotide sequence ID" value="XM_010704140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SIM2"/>
    <dbReference type="GeneID" id="22578518"/>
    <dbReference type="KEGG" id="lpan:LPMP_340140"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340006600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_340140"/>
    <dbReference type="eggNOG" id="ENOG502RZ84">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="239978at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO01642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="255" mass="27951" checksum="2B5B7C927E69A0D1" modified="2014-11-26" version="1">MQRFVPAWTVQASQEGDTPTRFTLPLPSHFINSGDSADDFEPRAFFLEKALPEGTNIGGRTPVFPRCGHSGLFFAREEVVDNLQAAAADLKFSSPFWLRKNHPGLESGYLQLKEGNETIVISLTASIVGFGDVETIEAAKLHPLLRKAIKGDINSAGGLTVSDELPLGMNALTGAVTKNPFVCSLPNRGLWLSQDQLLHHNIKLSRHIKQAVSAFTLVEIDQWELFNADQLQVPGRLGLRQSLNLAPNESVFQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SIW8</accession>
    <name>A0A088SIW8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_341350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702562.1">
        <property type="nucleotide sequence ID" value="XM_010704260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SIW8"/>
    <dbReference type="GeneID" id="22578640"/>
    <dbReference type="KEGG" id="lpan:LPMP_341350"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340019500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_341350"/>
    <dbReference type="eggNOG" id="ENOG502SAYG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272696at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO01762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="290" mass="32618" checksum="0CBDFBD923E17943" modified="2014-11-26" version="1">MTQIGQLYVDRAAGAVRLDQVYRAQRTTFLVDNRHLRGFFFFDTASGDGAPQDGNGNGSDKGPSQRCHVFYLPHKVAPFCVPQRYTASSRKSMVRGVPVIRFSGMERYDHTPLLEQHFYVLNATYAASGAPMTIPWRLELSARSDLELSKITAVPYESPHWRFFGHPMFDELVLSPAQESQVQLWEPVYNLFTVDFYNYYPTTLTLDVFAVPPQCTAVLVKSTSTGNSVAEEASALTRGRTTLAATEPLELVTAQLFFLQWHVLHNASAGLHVAKKIYELYGKGRCGWHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SKG4</accession>
    <name>A0A088SKG4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_351750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703112.1">
        <property type="nucleotide sequence ID" value="XM_010704810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SKG4"/>
    <dbReference type="GeneID" id="22579204"/>
    <dbReference type="KEGG" id="lpan:LPMP_351750"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350023500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_351750"/>
    <dbReference type="eggNOG" id="ENOG502SMPE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273361at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO02312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="556" mass="59382" checksum="19B6855621030619" modified="2014-11-26" version="1">MLSNNDPLFYIPPAGLLRTDSSTMTNASAFSHMHLVSNPDWMSSLSANQQVAAARPARVPPAPVAVRPSAPQPLAVPVAIGTPAAAAKKSFLDIFYRSSSTAAPSKEMSQQASSAAFTLMSVPPKALDVFDTPPLRALPVDAQLPMVYLSKLDKVDATISAAPRHVPPRPMALGSDTWNALSSVPLPPKTKTRFGPLLAPPISIDGVSSGDPTPSWKSLFFSSRFRGTAPTLEAFQNAPPEPIRSTSPGSPQHWITTTSTTTVATAPIPVPPKPVTGSPLRGATVRSLEAGATAAMQVMHHEPRTVAHPLVPVGEDTPAVVKSMLKPVQQAPVISTMFVNPAPNPVSATSPAKEPAPLSLTRNEPEQVWLPEHVEESVSPLPKEFTKSIAGPTMEQAQRDEARTLANVRNFISTLFSGGRDGETDSSTTENKKADGFSALEFVMNRRGTQAKASQPADYSSFFNTSFFDDDCDEDSEEGLEKLRRVISIVMQSAKNHDGNSVSEPISQSCCRGEGGDGTGVVTLTPFPSKYTEFSASYQTTSNNANDNEWRQFAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SKL5</accession>
    <name>A0A088SKL5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline transporter-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_352300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Choline transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703167.1">
        <property type="nucleotide sequence ID" value="XM_010704865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SKL5"/>
    <dbReference type="GeneID" id="22579259"/>
    <dbReference type="KEGG" id="lpan:LPMP_352300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350029100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_352300"/>
    <dbReference type="eggNOG" id="KOG1362">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="44736at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF4">
        <property type="entry name" value="PROTEIN PNS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO02367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="508" mass="55683" checksum="8884EB85BA438ACA" modified="2014-11-26" version="1">MSKVYTDKQGNGKLGKGLTSTDAGIPIRGGDEYTSNFNYYPPADVNYEQFSGTPADGTLLYPEVTSNAAEAPRLSRFRIRGFKDVWASIVFAIFVLFSIAWSIVQLATYRFDPDTSGRSPFSSASGPRLMWIVIACLLSAGASVISSSALLIVAQRIPVQMIYVANIMTILMFLASAVAAFLRLNIIVGLLMVICTIFQAVWFFLVRDRIPFAAALLRTSAKLISTYKSTFVLNLVLCVVTLGYVVLWGYGVAAPIDRFYKETANGGYGFVIAVLVFSLMWVSQVMPNVMHVTSSGLVATWYFAGSNNMPRNPTLASFKRAITTSFGSICFGSLVVAIIQFIRWLVESSGSDYENGFLRCLLECMLRCLQSIVEYLNRYAFVHVAIYGCGYIEGAKRTFALCKQCFFAAYFNDCLLAPTLNMFLFAISLLYALIAGVVSRSWPIGVLVFCVAAMVHSLFFVPVDSAVTTVFVCFAECPDALRESDPELYAAIYAADANGTNNNALPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SLQ1</accession>
    <name>A0A088SLQ1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_356080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703537.1">
        <property type="nucleotide sequence ID" value="XM_010705235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SLQ1"/>
    <dbReference type="GeneID" id="22579636"/>
    <dbReference type="KEGG" id="lpan:LPMP_356080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350069200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_356080"/>
    <dbReference type="eggNOG" id="ENOG502SQGE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266822at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO02737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="523" mass="56892" checksum="AA8259F17A75C27D" modified="2014-11-26" version="1">MYSDSDIDGYVSEVFSESSDLLTNSEEASLLLEKHEQAISTLVSGYACVFEASDGFFRTQFGSHFLSPDAEDQAMAAVCTCRLSATDVAELLHVPAEEQIADNLRNNGDASPSCAAMPSDHPLTATSLQLSESLKAWVEEGKSSPASRFLCANRESCILIPVDKALNRTMLCSAHQELFVGTKGVGGEGLDIVPGYDHSKAIGWALPLSTDPAVLDVLKSLHPGWRGATPSDVRFWTKSQSKTGSTCIANKVQPKPSRRTWTRGAAMLMLSKERLLARIAAAGDWSNITFVAVDTEAYAVMAHSVPLPAEYAFLPIHSSHASTSSAVLSPLHFFCHPGNVEAENEENVLYNCLNTHLIPYHSATFLTDNFYDKAVLVDRQFVRNPSVILISKGAPSSPTLMDMQALRWLYAAAALQWHNGHTFTALEEKGALEVGNWIPSAEDIYCFDISVLEAVALERGGIADSQGTPSLTHRPNRGARREENGYCWYHSVVNECDLIQGDVHCAMHDAYTLAGRIKAVLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4J0</accession>
    <name>A0AC62A4J0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Membrane associated protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_322400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="XUY36704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1785" mass="205594" checksum="5571306B44E33392" modified="2026-01-28" version="1">MWGFLSDVRESVRQVVAPSPGVSNAASAAVPSVTSTTTNLREMDFEGAVDQVTTGLLRLWRKVDQTASKVLRQAFDGAFSPREEAVPRLFTLTAEALASLPQDELLDIIRDAISQTNDRMHQALNEANFLLSLGIEEQIAHTNDYTGCYEWWDRTVNRRLIVCQDLLQARFTNTSSTQKQLSTVMALRAQMAAIRAASTQPMAAIAARGRLLEDERYDLLQSLPAILPTEGSMHPAPVPPQALDYTLSADDHDIHLPHSQPTPTHSVESVGTAIQHEPYKSPFHPLNTSTPPAPPTSQHDANTVILKGCTLSSSATQLPSEHASLLPVLHSTEEQARLERHAEEERLARAAEEEQARLERHAEEERLARAAEEQARLERHAEEERLARAAEEEQARLERHAEEERLARAAEEEQARLERHAEEERLARAAEEQARLERHAEEERLARAAEEEQARLERHAEEERLARAAEEQARLERHAEEERLARAAEEEQARLERHAEEERLARAAEEEQARLERHAEEERLARAAEEEQARLERHAEEERLARAAAEEQARLERHAEEERLARAAEEQARLERHAEEERLARAAEEQARLERHAEEERLARAAEEEQARLERHAEEERLARAAEEEQARLERHAEEERLARAAAEEQARLERHAEEERLARAAEEEQARLERHAEEERLARAAEEEQARLERHVEEERLARAAEEEQARLERHAEEERLARAAEEQARLERHAEEERLARAAEEEQARLERHAEEERLARAAEEEQARLERHAEEERLARAAEEEQARLERHAEEERLARAAAEEQARLERHAEEERLARAAEEQARLERHAEEERLARAAEEEQARLERHAEEERLARAAEEQARLERHAEEERLARAAEEEQARLERHAEEERLARAAEEEQARLERHAEEERLARAAAEEQARLERHAEEERLARAAEEQARLERHAEEERLARAAEEEQARLERHAEEERLARAAEEEQARLERHAEEERLARAAEEEQARLERHAEEERLARAAEEQARLERHAEEERLARAAEEEQARLERHAEEERLARAAEEEQARLERHAEEERLARAAEEEQARLERHAEEERLARAAAEEQARLERHAEEERLARAAEEEQARLERHAEEERLARAAEEEQARLERHVEEERLARAAEEEQARLERHAEEERLARAAEEQARLERHAEEERLARAAEEEQARLERHAEEERLARAAEEEQARLERHAEEERLARAAEEEQARLERHAEEERLARAAAEEQARLERHAEEERLARAAEEQARLERHAEEERLARAAEEEQARLERHAEEERLARAAEEEQARLERHAEEERLARAAEEQARLERHAEEERLARAAEEEQARLERHAEEERLARAAEEEQARLERHAEEERLARAAEEEQARLERHAEEERLARAAEEQARLERHAEEERLARAAEEQARLERHAEEERLARAAAEEQARLERHAEEERLARAAEEEQARLERHAEEERLARAAEEEQARLERHAEEERLARAAAEEQARLERHAEEQRLARAARESLEHAIASVEERETVERAKLAREAQEIFATLYGKLMMSWQGMVMGTRSPSESRTMVFPAVTTSNDDSGWGEDDEFEEINMSHFKREVYSPHRGSSYGAVYPSTPLSTLSGCTQLQTPASAQRDAPMTRRTHTPSATPLPGAQGVGVVATAATVLDRQARGVGFRKKSPPVRVATGSAALTPVHQSHGCISRSSSLSIPYSAAANPSLARPRPRPAAPQSVFSSPGAAGKQPKRQVQIEDDDKWDDDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A524</accession>
    <name>A0AC62A524_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Elongation factor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3520010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="XUY36832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="845" mass="94218" checksum="D34927335D0EFFF3" modified="2026-01-28" version="1">MVNFTVDQVRELMDFPDQIRNMSVIAHVDHGKSTLSDSLVGAAGIIKMEEAGDKRIMDTRADEIARGITIKSTAISMHYHVPKEMISSLDDDKRDFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCVEGVCVQTETVLRQALTERIRPVVFINKVDRAILELQLDPEEAYQGFVKTLQNVNVVVATYNDPSMGDVQVSPEKGTVAIGSGLQAWAFSLTRFANMYASKFGVDELKMRERLWGDNFFDAKNKKWIKQETNADGERVRRAFCQFCLDPIYQIFDAVMNEKKDKVDKMLKSLHVSLTAEEREQVPKKLLKTVMMRFLPAAETLLQMIVAHLPSPKRAQAYRAEMLYSGEASPEDKYFMGIKNCDPAAPLMLYISKMVPTADRGRFFAFGRIFSGKVRSGQKVRIMGNNYIYGKKQDLYDDKPVQRSVLMMGRYQEAVEDMPCGNVVGLVGVDKYIVKSATITDDGENPYPLRDMKYSVSPVVRVAVEAKNPSDLPKLVEGLKRLAKSDPLVVCSIEESGEHIVAGAGELHLEICLKDLQEDFMNGAPLKISEPVVSFRETVTDVSSQQCLSKSANKHNRLFCRGAPLTEELALAMEEGTAGPEADPKVRARFLADNYEWDVQEARKIWCYGPDNRGPNVVVDVTKGVQNMGEMKDSFVAAWQWATREGVLCDENMRGVRVNVEDVTMHADAIHRGGGQIIPTARRVFYACCLTASPRLMEPMFVVDIQTVEHAMGGIYGVLTRRRGVIIGEENRPGTPIYNVRAYLPVAESFGFTADLRAGTGGQAFPQCVFDHWQEYPGDPLETKSLANATTLAIRTRKGLKPEIPGLDQFMDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5D1</accession>
    <name>A0AC62A5D1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_344960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="XUY36831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="368" mass="39399" checksum="CE4FB99A2022BF22" modified="2026-01-28" version="1">MAHHLLSPLDATAKLPVRQKEFKFDSLCVNADDRLTDGMAIKSEERRGFRPHTRLHPSNAGRTRGRTGGALEIGFMESLPFRNEALVEEKPSHVVRPRARQLRASEGNTDPLSIPCVKAKGSVARSLHATPTANPSTQSLWVEGSSVLNQGAGLVSAAVAHRSDSVSPESPPQGGVGGGVSGEDSRAVRRCETVHAVLHRSGTYATPTSIGDKVVSDALAVARCSVIANALAGTRRNVVRTFCSRRLCAARDPVSGPRLLPNIARLESPKFAMTFFSSVPGGTASSLDDSYASPSHSVSDYLEEEEVHRIKQLYFDYFDCEPVSISSVGTSGSDMSMFAYGATASPRPSSSVSRGDRRSFSQRASNTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5Q2</accession>
    <name>A0AC62A5Q2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mannosyltransferase-II, putative</fullName>
            <ecNumber evidence="1">2.4.1.232</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">GPI18</name>
        <name evidence="1" type="ORF">LPMP_1820080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.232" evidence="1"/>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="XUY37119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="685" mass="74879" checksum="57A033B6D7B7A41E" modified="2026-01-28" version="1">MALLQRSVVASVSRLLASVLAPYAGFSFNLLDYLSTCTDTALVLCIVVARLLLLCLMWFSRTVAPILFRAPGGSFVFDTSEELYDDARFSMVRNWDGAHLFFIAQHGYLCENQVVFFPGLPVLIRSLEHVTRQLAPVLHRIAPVAFYVCLVNITASCLAGVLLRRLTILTFLGPEAVQCTCRWRSAKRPSSTPELEKSSNYAKMQLSEAAEATIQSTTEATLCYRLMCGMTGTVLDAPDIHAPLPATVAEAKEAALRRRRIVGGAALAWVITPAMVFTVVVYTESLFALVTMFGLYLLAWHEPLPWAVQLRIASYLSSVTTPDSAATTTSKAPAQARLAPPPPLAQQWALAASTIGGGATARSRIPGIPSLLRNITPGASGEITMVWKQSFLSSAEVAAVLLFTLAGSFRSNAFTFAGFLFFPLAVQLALPAVYEAQASAVLAGLSARMAMSAAAKHGGAGKDRPCRVARCPTLRPPLQRIPHPLRIFIVALECTCVTLPYFAMNYFGYQRFVLQVWNATDKAHIGHALWNLYPMLQKKHWGVSLFSAYTFINFPNVVLALPVALLTIRCICIYYLAPAWLNLRAAAAPSAGAWRTTQQRMWIAAVALVRSSNVVHLVALLALALTVMHVQVTNRFVMACPALYWLLGTQLATRPTSLVSELTLLWCILWGMLGGIFFPNHLPWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5R5</accession>
    <name>A0AC62A5R5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATG8/AUT7/APG8/PAZ2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ATG8B.1</name>
        <name evidence="1" type="ORF">LPMP_1920120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="XUY37133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="127" mass="12834" checksum="EF18415DD8E68F1D" modified="2026-01-28" version="1">MSAYQSSNTAEARRAECARLQAKYPGHVAMVVEAAKSSKAHLLALPRDATVAELEAAVRQALGISAAKVTLAVEGCTPAATAAVGDVADACKHADGFLYVSVRGEQPMGALLAGFAGPCFASDSGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A631</accession>
    <name>A0AC62A631_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amastin-like surface protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2020890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="194" mass="22191" checksum="6A5C0B5FCE518DDD" modified="2026-01-28" version="1">MEFNPFIIVYAAIQFIAFLLVVVGTALDMFRLQSRENFEDRPCITLWGLKPYCNSIVYSLSSDERFSLCPVRRKRFHMAQILAVVSVGVYGTAFALGVIMLYCCLHLRWVCLLLNIVGFVILPIPLALMVLSYKTDENSLCPKLRDDYDFGVGFYIFATAVGMDFIDIVFLLIPWQYDYLDVTCNSKEGNSQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A665</accession>
    <name>A0AC62A665_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histone H3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1620700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="XUY37081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="66" mass="7238" checksum="D87F239EB5F19D1A" modified="2026-01-28" version="1">MPCARCRACRRRGGPALPEQRDPGDPGGVRCVADGCHEPGQHPREACVTVRPKDVQLAVRLRGERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A677</accession>
    <name>A0AC62A677_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amastin-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0820180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="XUY37298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="187" mass="20790" checksum="A795E9BBC66A4B78" modified="2026-01-28" version="1">MELTLALLLYAVLQLIAFLFVLVGTPIDMFRSRDEAPFGNTPCITLWGFKDKCYSGMLSQNSDDLWSPCPRRRDSFRAAQAFAIISILVYGLAALFGFIMLCRCPWLRVVCLVLNVTGAVTLCIVWASMVVAYSTLDRPCFGLRSRNNFGSGFVLLVLAWCLDIINMVFLLLPSQAKDPSGIADTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A684</accession>
    <name>A0AC62A684_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Serine/threonine-protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2020510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="986" mass="104426" checksum="99A3EFC9452A5545" modified="2026-01-28" version="1">MRASIDDENSSVAVTLLPSAQVSPLISSQFPTRTGAISTATADTDAINAPGSGAASPDGGDTPSSMATMTTTNAVLYYPSAQLPTPPPLHRPSSSPALMQQSQHEVPAAVRAVPYCPLSCESDSNEEPLFQRPPPATPIVPSLAYTTSSSPLFFTSMQAPQPDRLCGAVSAKPEGGGHARGGTALYASLLPIPSTPTMATTETPGTLAGKRSAVARETSNYSLAEPTKTHVSASSSNAARIHGGYAGSSNKSTAETTVGNHSRGDRGVQRPLLMTAPNGVAVASASPAAPVTLTNVGDTVLVAELLPPAKQRRTIHTGVGNRGTLPSGGIGAGPGLSTTAASTGAWALGAATASAAAAAGGASPKPSLRIATPLRGFGRNPVTSHASGSVSRATTSGAGTAPPPQSFKLYRREGSRKRSADVLSQFSALDLDETPTTPFAETGACNFTSIIPNSNVHNAFPSQPSPPTTVYRGAGGGSNAIGAVSPLIIDYATPVTLSQQIGGSNTFSQVLLHPSQDVLDVSQADTECSNFLARRILTEYNEVRLLGRGSFGTVSLFKEISSGEYVAVKMSPPLRTPEMERRYRRERSVMGMVRGLPHIVQLSAAWEEGRVPRMYMQLEYCPGGSVASVANEKQDRNEPWPEAEVKVFLAHMSIALDALHRTSIAHVDFKPDNILIDRDGAYKLSDFGCSVLLDERGRPRPETRNGYGSPARGQRAGEVGGVTYVNPNSGPVVYTGPGAGELATALNPDSWNDGNELSTTSVDEGDCRYLCADMLNEKQHFKAGDMFSLGMSLFELMSGQPLPRNGDQFLALRRRVPVEMLHRRGYSADLVKLVVALLRSDPTQRPTARQVLQYLRPSSEQLQLLSSSSAMQQWTESAESFCRLQVEEQQQLLGNDGAVTATVDALRCVSALMEASMWLFTTTQQDVHRLAAPANPGKGEEEDEQRCQQPQPPPLPLLQLPRGRRLEMPIPPSQRDEACTPTTLNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6A6</accession>
    <name>A0AC62A6A6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amastin-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0820020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="XUY37282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="187" mass="21250" checksum="68964CA9A4383FB9" modified="2026-01-28" version="1">MEFTLVFLLYAVVQFIAFLFVLVATPLDMLYDKNGSRFDNRPCVTLWGTKDECYGLTYEMTSDEVWNVCPVRRNRFRAAQAFAIISIFVYGLAAVLGFILLWCCSHLRFVCLALNVTGIVTVGFVWASILVTYYKTEFPCLRENLYTVLGSGFVLLVMAWCLDIINIVLLLLPWQAAHPSESGETKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6N8</accession>
    <name>A0AC62A6N8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0220290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009371">
        <property type="protein sequence ID" value="XUY37414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1125" mass="126583" checksum="2E0341F370585352" modified="2026-01-28" version="1">MSFSSPLDGGGADSAAEPRASLFTAAENTEFQAILAECSTFPSYERQYQEVLMTLEGDDVLDKFRAEYEGLHRSLLRSHESEGRLLRKCTDLQSDIEACAERAVTAAGLTLGDRDTIAHLKSETERTSNRLVQVKEKEAQLKEAIDTLKRDIAEQQAKAQDPIDIPEQEAALRSLRGLHEALQREEEQLVQQFRSASLDVAATQRRIAALLNNNSTNAAELSLVREMISKTEEEVQTVLASRAVKEQELKAVRDTIARRIASHTSQQHTLDALGEDHERNGQELRNIRHEETRLTEEYQGVCRQLQHVNTALQECSEENDLWQQRAHEKAAELQAYQAAVVSMHRRYIKAQKVVEALQRRNAVTEEQRSEQLTKHRELATQLKSEEAALARAKQAAHATTQTAASVKGEVNLLQQHIASEAAEQQRNAAWLAEKLGQLRVLESVLASSEEHIQRTHQEVYVLTQEAEISEAGAKKYASACAHLLSDVENKGAMVAQYEEQLTAVEARVKQQQALLESMVGERNTYTSHYDQLKQGLSEQQHHFTLLVAKVQSMRSAIEKREKDVTLEAAHVQLLQKQQKDIEVHVVDFERRANKKQLCAEALGQEIRQLRAVLSDAADETRRQQRRCHDVVHERDMLDRQVTDRAAEVQALYEQAHTKGFLLRRHEALYNDQAQQLEHLEYQTVQFAQQLEKMRTFVARLPELRVLLNNATRELQREKVRVQVLLDDAARPVNVHPYHELASAEPETHALLQRVQRLQRVLVQRRNELEEKEVAIQSVEQRYMNAKATVAHQPGPEIAEQLTAYQQNLTKKHQDMRQMQEALEFFRSQTDHFKARHDVLRERLADMGKAYAAERAEKERRTRAGVIAGAPPITPRADSPSATPEPVVYRGFVAPPRAAPTTAFTPHANPDEGSDLPPPWGSTRERGTAVVTAKALRTGGTGSFSRNAPPSLSPFSHWHFTDDVQVCVSLLFSLFHSLRRTRSPAPLSLSLFPPSPSLAALQTQLKRGGKPRRYCPLCSSRVLCPLHKAPPRRRESERCGGARHVVRHVHLSRCCSPSTLCIPDPQGLGGWGLRDASARGVSCTSAPTLRGKAKQPPLFPPMLNLLSGGGPCHHLRYSEARAMHHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHA6</accession>
    <name>A0A088RHA6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Anaphase promoting complex, subunit 10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_040350</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="AIN95362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703684.1">
        <property type="nucleotide sequence ID" value="XM_010705382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHA6"/>
    <dbReference type="GeneID" id="22571994"/>
    <dbReference type="KEGG" id="lpan:LPMP_040350"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040009400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040009500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_040350"/>
    <dbReference type="eggNOG" id="KOG3437">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="24948at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000233">
        <property type="entry name" value="Anaphase promoting complex, subunit 10-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016901">
        <property type="entry name" value="APC10/Doc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004939">
        <property type="entry name" value="APC_su10/DOC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03256">
        <property type="entry name" value="ANAPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01337">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51284">
        <property type="entry name" value="DOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DOC" evidence="7">
        <location>
            <begin position="44"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="177"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN95362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="339" mass="35656" checksum="57943983A4A4DD39" modified="2014-11-26" version="1">MEDSGDYDRESSVEELTQSQESEPVVSSASALPDTSSSTGAAVPSFQVLSAPQLAQWARAHNQMDVGGSGNTVWTVSSAKHGNGVRHLMQHHDLNNFWQSDGVLPHVIRIQLGQLTPIEAMAVYVNSAVDQSYSPRVIRVKAGTHSGDMTEVAKVDIGAGQECGWVLIKLGEAAGDTSEDLGGGENDGGGGGGGVGRSGGAAKRQRQQAGSTRSRGPWGAASPSPSPIPYSKVAAALRHGNHAASSSAGTQTPAAIQMIAHNTSHPADRWLWCTVIDVCICENQFNGRDCHLRGIRLMGPRYEELERVSNADAADMVTCAGPLRGGELLEGTADELQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHE8</accession>
    <name>A0A088RHE8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_030730</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP009372">
        <property type="protein sequence ID" value="AIN95308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701016.1">
        <property type="nucleotide sequence ID" value="XM_010702714.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22571939"/>
    <dbReference type="KEGG" id="lpan:LPMP_030730"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_030011900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_030730"/>
    <dbReference type="eggNOG" id="KOG0606">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0610">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="243301at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE GREATWALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="45"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="178"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="226"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="311"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="416"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="701"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="866"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1239"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1472"/>
            <end position="1505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1546"/>
            <end position="1581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1883"/>
            <end position="1955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2042"/>
            <end position="2120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2365"/>
            <end position="2408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2436"/>
            <end position="2461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2474"/>
            <end position="2581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2593"/>
            <end position="2629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="490"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="534"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="556"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="904"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1242"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1486"/>
            <end position="1503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1554"/>
            <end position="1581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1893"/>
            <end position="1905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="2054"/>
            <end position="2068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="2084"/>
            <end position="2093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="2437"/>
            <end position="2446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="2447"/>
            <end position="2461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="2518"/>
            <end position="2530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="2542"/>
            <end position="2553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="2555"/>
            <end position="2574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="2618"/>
            <end position="2629"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN95308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2629" mass="273906" checksum="D1B4E08FAB7581AA" modified="2014-11-26" version="1">MDSPLTGDRVTTSRRGSAGGASHPQQQPTRRSRYVSSAARSLQDYELIAFLGSGTFAEVTLARNKVTKEYFAVKKISKQRVKEEGCVERTFTERQLLAKLHHPFLVRLYQAFQSQTHLYLVLDFAQGGDLYYLNMQQLWLRSMRRRLAKMQYPYYQCASNTFTPVLVPIAPVPGRTGAAAATAESNAQQQQPKTSLPPPLSLQAGGSRLTTGLTLRPLFLSSATTQPPKATLNAQPQQPSGSNGTTTTERDALPAPSAMVGGLGPDAVSGASQSGIAATSTITGTARPLPPAQGGYASGMNDDADDAVAAVTKEEEDMTASDGAIGNNDSLVDAPPFMVMRRQEQQGRPSQRGVADRPNPSPRIAAGWPHYTADTVDEVNFSCRGSAVAFKAFTAGGEGSRSSPTSVIIPSTSEVTGLAAMEESTPAATRDTKAASSPTPAAVLVMSKTQVPPLQPPMHSQDKKNGSGGYSNNDGAGGAGEPLRDAGGTDATNVKKSRKTPSSAHPSTTEAMQKLPLASDNSRTATPTRHAVATSPTGMRTQRGSSSRRKMAKANLLDDRGKDDEALTSSSLPLSASATTTSFAVATAGQGAAPTPASLGVNLATSFHQAAMEGSTGVLPRLLSAELAPDGGHRFPLRLIAFYAVEVALVLQYLHREGFLYRDLKPENILMRGDGHVMLTDFGVAKYRKGAAIIPSASGDGVNGEDATNSSSAVGTGADGRANSFTGTTQYMSPEMLRGQPHDSRTDWWSYGCLLFEWANGRKAFDAQNQFALFRSIVEEDVKITPEDYRLTPLEVHTRVAQLHYRTEEVRLECEEWVARRLRRSFTSPLQRSRSPSTFIAEVVYNPDNRSFDVLLRSPAMSARSAQPDIDGSFAATEGPEGAVANNSVSSSTPHRHAYPRLHSQGYASPQSPAAAAGAPTAAMLDDSFASQLGTLRLPKAAGAEDDPPGPPPKLVLNDSLEASSFVATGFSSSLSLCGAPTNLSMHLTTTEDGATTALHQQEQQERYRHHQRRRLRLSCLTLDEATRDRYVGTAVAQMDEAQALLRDLTVKLLDRRVEHRLSGEAVLEHPFFTCSYIASQLYYEVYQRRVLPTELRRLVRASLGPTSPTGPVASTWDEALQQSITPSSPLPSTSTAAAASPVQSSFLPAPLQQPTRPEDWRQLFMERRIRAPYTPRLRTRDDLRYFPAAVTATGLSAAVEQHRRIKQVKEQQRELMMMRANKAAAAVMNNSLSGGGRFTPTLPSSRTQVPANSSGGGGSFAALQPLDAEAVQQLPATTTPSNSLSAYNYDGASHLPALNPNKAAAADISDVKTTRGASQAATAPAARSQGPTEVLQSLQLPPVEVMVSVTADLGGAAPSPRRPADVLAQSPAACDARRAGVAKEAQLDASPVQHPLLHRHSGALPAYTGETAAGTMEGVMREPSPLSPTPTTTPMTAIRRVEGERAEATASLPHPSRATVLPLAERYSTEMASSCASPEDTPPSAGRVSSAARGGAAADGVEAGNGGAMTTAVVEESPSDLFDRAATLPQSFVDAALAVAAAAQKKQQRSVGPTAAPGATAAAAESPRSPASTDVARSTGADASALAAALPTSLGAPPLPQQQQQQQPARVDFAALGCSILSAGHGMAYAADDGADARLGRILPKCGSIDAHSVAGAEIHAEEVVDEDEDHDGGGGYYEQDAFAEDDAHVVDAGDATVVEEVVSIAERTTASNSATATAIASAMDASSCDDSHVSARTVTPMQQATMFRPSTVCSSAGTSEWGNSAANPLSPNSGGGVDDKVNNAGSRGNMSPGGLFSLVPIEVPPTANVSLSFSSHTHSLLDDGATRPMHDFLRETPVHVSPLLSRGCEEHCSLSGFAASSVSSMATMPFDDLQRSLSASLGTSGADGADGTSSTWAMSSPTDPASAERGHQRRGHHNPLLDIDSNESQGGSDKASHVLPSLTPGEQHHQQQQLLSALTSIVSPLSPAGTTSDTVLSGEAADVLSCATVPTAVQRLADTRVSVTSGGGAEAPPESLCDAKRHSTNDACAGCPQTSAAFPDVGHRGAHPSRATAASITQVASMSASNDGADDGETTTTGSSSERVDGGKSESDVSGLGNSARRPVIPAPASTWGGNVAGDTRHSDSALSLLGSSVSSISTTTSTSAHTFSMSSGASSINSETNSDTAVAADAGAAAMYHTTTCPSMVMLAGDDRRGAGGLSSSFGSHNRGGATSLSPYGTLPSLDAGSGGHRRRHGNGHRIPHWYAHLGGDAAHGGVGTTTPFAAADEMVGNPTLGSNPTASVLSLFTENSGSTLFGTATPSAVNLSTTGSGTGDAAVFWGPLTTTLSGVAYNVDDEASMGTFPEMPVTPLGSCDGNSGSACRPSLDYSGRGQGGKDAIGNSSNRGSGGPSGTSERRGVQALWAQQQRKRIARGLQQQQQQQPDLSPVASLLLHGADTESGRRGTSDSGDQQWYGTKRNPSNATIFADRLVGFTSDDGGAGQPLGRRRNSVVDQPEPRQPSLGIPYHRSVGDDGAAQRQSSSPQSGGEQSRSHNLVGMRGYQNSSLANSDNQGGADGRTGATSGGGDGGGGGLDHFQNFSFTSPQILQQYLASSSFGGGGSGDREGRLPHYQRPRRGRLDGGGADRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIA2</accession>
    <name>A0A088RIA2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_060640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703945.1">
        <property type="nucleotide sequence ID" value="XM_010705643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIA2"/>
    <dbReference type="GeneID" id="22572270"/>
    <dbReference type="KEGG" id="lpan:LPMP_060640"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060012100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_060640"/>
    <dbReference type="eggNOG" id="ENOG502SK7T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267542at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="703"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="785"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="879"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1246"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="737"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="839"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="892"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="922"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="991"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1255"/>
            <end position="1271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1271" mass="130514" checksum="A261C4BA707DD437" modified="2014-11-26" version="1">MGGACSRSKTKSAKHNHDSATGADASRNNGGSPEAPVADAMPSASSNPQYPISDHNSEVDGLPRPLGAGSFTCSTSGEPRNSNTSGDLSKNSGFISTKAPSRESAAKANNVVTAMSSITPVSPSMKNGGASSSPVKGGPGYEAYFPPGHDTGMKLGAGKYTGVGESSLSGLSSSDMQSLASTPFYNAEMRKQLDQAPHRGTGLPLPNPMIFSDEDTSIVETGSSAFATPRELQKGSSSVAGFTDNASIISRGSMTSQQPHDYRYYNSSTVDANNFPVPSSVSRPPFVATVSLTPTAALLNNSQRQQFQQQPQAFFPTPSATRAARNARTNRQVPATFSFGGASTPLTRQSSIAGSDRFQTCRSYTEQGSSVAGYLPPSTPLGAPAEADARFSSGYPASNAGGVPSTGRPLYTCRSTYTPVTNSLLVPSPAAAASDPAHQMTLTYSHNRERLSTVPDVSLLPLFSPQRTSSGAAALNTQHAQQLYERRQASLCSGSMDVPASEAFSVPPSSREFLDAPSIAASASADWIDIDRGFTNTAAAANISHQSTATSLTGSVGAARKPGKGETSDVSSLEPNGSSFFDKAAAPSSLVDAPVLPKTRLPGEQEVKSAPAEAGGKAANQSDSNGSRSGARPRKPLYKRSDDFSPNPNPPLQTKLVISTGADAAVATTSKVHTSSLPTVAASTATLADNQGVNANLAFSSATSKTSAEEFGAADDSTATRGGRPTQPYIEAPLTPPGAAAAPAAAAAGDGNTVESLISPSASMESFAMVLLPHQRDYAVAASSRGSWELPQPQESNVTSRRGPLSSLGPGGAAPKKRSRRASAAFRSATAHKGKTNRAPATTATKGAGAAAGPASASALVPLIENPKPWVPGGAAMATPVATPKTARGMTHRSSLSRSGSTPKKSGSHTRAVTTPGHKGAGARPASGATVAAARRSRGGAANPGPGRKARRQTQASSSVSRPSATSVCNPKAKRTAKVEASPKQLPLAPPTDTLAPAAATDREPPDAEEAESIVEYALCIGDAMEREEVGVNPLPNNDDASISGLQRAAVAPFQRQLQPEHVSRPNDSVGVNDIEAGLLAQEHLPQLHDSSVEDADQPPLVGFRASPEVSNATAITSAAESAFLQPYTEAQLSAQSYLIASGLHDDDEHQHPISEDDRAAIAAASGEAVTRQTVYSSNSDEQGPYSVSTASGEEVAVVATSSSAMWNNAGSPITKYESTLPLAEEDVMPAGAVVSNGDAMCMAPADHSAEELSSRSVSSGSPTRTPRSCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIJ2</accession>
    <name>A0A088RIJ2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_060510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703932.1">
        <property type="nucleotide sequence ID" value="XM_010705630.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22572257"/>
    <dbReference type="KEGG" id="lpan:LPMP_060510"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060010800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_060510"/>
    <dbReference type="eggNOG" id="ENOG502SMKW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267446at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF190">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="818"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="902"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="999"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1087"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="903"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="917"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1009"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1117"/>
            <end position="1129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1821" mass="191104" checksum="B7C918181967F370" modified="2014-11-26" version="1">MASPPLSKLRNVTSATGEIHAPLPLHLLPPSPTSATAVLYERVRLTPSALQSIIGYLPCNATTTIGSTSNNTRNGGSSLGVGGAAAGRSVRSPLIMADALFAKAMQAPSRSAATAASTGVPLTPPVPVAVTRPLAFMAVSPQSRRELEMYLTGGCALPPLGSLVLQVRPHRPSPATAARLSRVGVLHASRRRAASPVQVEAAHQRDETVLAAPLALLFVSSTNVMITSLPFQPSLSPSIPPIKQPQAPAMTTLARYSVSRALPPPPPPMLLFRPSTPPPPARAVGYDDNVGRTPSSFSATPPLQQQYQQLSSRSTVHQSRRIPVAAVTPPTSFSPLSPVPVVQRHTSPVSAPHCLLNTTSPTSTTQEIFDMAAAGTESQAVFALGTRGVTAARIGFSTSAPLPVRLAHATPSATPLPAPAPPPTSAALQTLCHALWWVRRDRLPVSLSLVRYKQADTQALWAMLSEAPPPLPQERAGLVMADEGTGQPSSPMHERYGQATRPLGESQGSCDPTLASEGDVVCGGSHSADARGFRAPVDDLNRSFVSHLSEAAAMAANAERATCITQVTTTTIASSGCVRHAGCSVDFDPELTQPICSPRASRGEGAAANDNDDTLDYHLGRPTDTVLPLLGAPAAITLRFPVTHLHVHGKAADAAMATLLPAHPEVRSLRLTHGNLSDAQLRHLACVCPGVTHLSLAMNSQIQTTTFLCPPLSDTSSVSTTVTTATTTETSRTAATVAATAMGSPNPDFVQQFSRLNQRGVDHTAVTTTSTSMAVPALSSLSSRSTCAACDSGGDASHARLRSLWGAAAASDAGNALGTRREGSYATDASPVPSPSHPSHTPCSVRHSSQLDLFASDEEGELEMRISLWQAAQTEAEERRQPVFILRPQDVVLGRYGGTAVEDGGGSGASMSGGGRDAAAGATATTSSRTLQGSAIEPWTPSRRWSSLRTEATAMSSVSAHARPAHVLRKATSGAPLLRASSAAVPGAVLSAHRLPSATHASASAPIRTHADPRRDLPPRSSNILYPDLTVSPLRSYAPTLTSAAVAASSSSLSLPTPHVATAAADEAGSSVASAKGVDVRALAVPSPPAPAAPVHPDLSSSDWAMEPALPPDSPRHRSRERRHHRKGHSSSSSRSRPTYWADTLVDLDLSYTQVFDEDVARDLPQLRCLHRLSLEGCGRLSQVSWLPLLLHLRELNLSLSSVQGHALHPLGRCPRLVWLMLEGCSSFTTVHQLWSREADATAVDEATAAGSVEAAPLLTALRVLIASSTGLTDAGLRSLSKMVGLECLVLDRCPGVTDVSVAATLPSLCTLDVSRTRVSAEGVAGLRLSRTLNQLRMQECPALSRLPVLLVARDKSEASTAGGGAGDELSRLHHPKATTTGIAHRLLHKCPPLAVLDLSYTRQLTADGLTGLVADEETLTAQATAAVAEHLAWREVVPDDPDGMDLAVAADEPLPPALVFPHVRHVLLRSCDAVTHIRPLRGFTNVVELDLYHTNVTEAALTAALASWTALEVLNIASTRVRSLAAWCPYEPSETVGTAAAVARRGGDGERAEDDGDLQAVPPPLPWHGRLPAFAATLRTLALSNTDITAAGLAALAFFPQLEVLQLASCRRLSSLRFLALAADGAARRSTLTELTVTGATHLTNAEAFPYIMFCPALRFLSLVGCVQLGSGGNPPGARDSQHRHLLSCTDDDVGVLGCLRGLAELNLSNTGVDLLDLKCMLRASTSPSSLTATAAQQHQHLSQHVSLSLQRLWLRGCHHLDENALISTATAALEYGEPPCDGSRSSGGGPMTFRLLPLLREVYLSHGKYGAAVLSSLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIK7</accession>
    <name>A0A088RIK7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_060660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703947.1">
        <property type="nucleotide sequence ID" value="XM_010705645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIK7"/>
    <dbReference type="GeneID" id="22572272"/>
    <dbReference type="KEGG" id="lpan:LPMP_060660"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060012300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_060660"/>
    <dbReference type="eggNOG" id="ENOG502SEKF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267952at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="381" mass="40384" checksum="F4FE3DC35FBD66A4" modified="2014-11-26" version="1">MIRVFAKTVVPVMDIIELQGKIVITEEALSAARDAKERRRASRREPRRSGATNSGTALGEGTSGTDIGLLSLSTGSGSSSSCCSDSTSDEEDGECSAHATAGPSGDADFAIRRHGAADSLCGPASALRGPSSTTGASPAAPPRGPNSFFASRRATVVKVPLGHVVQDRLNGHRCTLCIDTLRVHGSRFSFKHPWLVLRECTPVRMRKLRRQMARTPVVRDDTHARELLTAGNGEGGGAPVAEPADDAASSSSVAPEVTMLFSEWLHQHPDMLSLNSLFLDDFDTGEKDDACARGPTSADPTCGASKSASSESTPRSVRGLKRPREAENVEDTALDCRSFSSHSPASTSNISSAATVYKNYEIVGVVRSAVLFNSKPERVFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIW9</accession>
    <name>A0A088RIW9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_070440</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009376">
        <property type="protein sequence ID" value="AIN95730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704052.1">
        <property type="nucleotide sequence ID" value="XM_010705750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIW9"/>
    <dbReference type="GeneID" id="22572379"/>
    <dbReference type="KEGG" id="lpan:LPMP_070440"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_070009500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_070440"/>
    <dbReference type="eggNOG" id="KOG2765">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1436450at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35, MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="526"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="593"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="620"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="409"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="141"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="270"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN95730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="646" mass="70301" checksum="9F22FF869AFC5CE1" modified="2014-11-26" version="1">MPNWPSLSAQESAGGAAEIDDAPGSMIIATQGSGLRELADRAYNKGLCAVDHLRSSMALSKYSLGVALILCVTVIWVESSVWIQHIFGTLEFNKPFFLTYFNTTGFCLWNTGFFLSARWRRTSWDETSQTQPVCVEDARLYSRESSSTEEAERQEAIEEGTEDSAGGEHSGERRRKREQHVGIGDDTRLPPVRVGAAREMLHDRRAVSGVSLTLSHSALRARSNTECGVQRSLNLGSSSLHPLLSAGLHATQPPLYGGVHLSRLAMSAASDRPARAAPSAPPSPLRQVRRGGGVTDRSVLADNDGIGGDGHVDNVNGVARSVMQLYVADECRDYSLSTSSASSAREEVVSVILTDEDALVDAAPWQVAEGREIAITSSMLRYNGTEVPPRRRHHQRARRQRIRRYSLRRIWQCALFFCPLWFLANYLFNLSLSFTSVASNTILSSTSSIWALFLSYVLLRQRVSAHQLVAVGVSVSGTILVGLSDKNAANGRNTLGGNIAALLSAFFYAAYTSVLKFHLPDDERFAMGMVFGAVGILNLLLLWPGLVLLSVTGAEKFAWPTWQQLWPLLMNSLIGTNLSDVLWARSVVLTSPVVATLGLSLTTPLAMVVDVIFKSARFSGVYVTGAILVMAGFLLVNLPIQTSLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJ12</accession>
    <name>A0A088RJ12_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chaperone protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_080850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="AIN95893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704215.1">
        <property type="nucleotide sequence ID" value="XM_010705913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJ12"/>
    <dbReference type="GeneID" id="22572547"/>
    <dbReference type="KEGG" id="lpan:LPMP_080850"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_080011200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_080850"/>
    <dbReference type="eggNOG" id="ENOG502S58B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46620">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN SPF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46620:SF1">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN SPF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="22"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="164"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="326" mass="36681" checksum="8C870501A718CFA4" modified="2014-11-26" version="1">MSEVQQAAEIARLLACKARKASPFEFLQLDIATCELADVNRQYRKIALLLHPDKCQLANSTDAFHAVEKVHKSLSQEAIFYHLKRAYQRQQDRLVEEGTSATATGSHSVPAAGAATGQKRAREAETALPPIAFGFLTQLATSGLSSDAQKAAEVRRVLQCKASDYFIILDVDPSTCTVADVDRRYRRMAQALHPDKCQLPHVQEAFTVFEKAHKELTDEKKLVRFKVAFEQQRKREAALEAAAAQRGMSGSGTGTSEFGPEEGLTAEERLQKRRMEALRDQQLEAARLGEEAARRRKLKEEKEKEETALAVELERQRKEWRDLELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJ68</accession>
    <name>A0A088RJ68_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_080360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="AIN95845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704167.1">
        <property type="nucleotide sequence ID" value="XM_010705865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJ68"/>
    <dbReference type="GeneID" id="22572498"/>
    <dbReference type="KEGG" id="lpan:LPMP_080360"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_080008400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_080360"/>
    <dbReference type="eggNOG" id="ENOG502SIZZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267854at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="640"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="680"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="728"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="826"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="935"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="782"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="847"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="882"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1164" mass="121966" checksum="82CF89D56AC33A68" modified="2014-11-26" version="1">MSRDAEAGSASGSSVTSFPSTSLLPRLTRSYSDGLLISQCDSASSHTGSLSAHGMPTNSLTWSPPRPVTCVNVAAPAPAVQSTNASQVSPVWALSTPHPTATVTSARTAAAMERTSASRATCRVVAGCRISPKLTELLRAAATREDGDAPFLDVPAEVLLLESSCGTPSTQHTRRGEPATAAPLQGIAHAYPTEPPLTATSGAHRRTSPSSPASISAAEALMVDPDAPRSSRQHLSYKIHAAPRNGTNSARTSGVLAPLSGTATPPTSPFTKSGARTPASSPVVAYRTTAPPSITSPVSFGGAMLILLTPKSSLSGAEVEVTPALLLGGGTAVTPSVHPSAAQSPGVAATTTSSFSAATGALRPLPSSTPSNAHGGGQHVEVPLCFQGFAVYRHNQLERHISVSSRGRSSPAASAAVTTSVLERSRRTSSVASALSMSGFTDAPYDFDGFLDGAAVSFVGEADDLHGDPLYNGNDSGDTYEDGEGYRMVDDNDDDGDGSCHDVVQRRQRKVVMKGAMPPAAAVAASESESELELSQGQELTSMQWNGNVYTCATANFNVSGPVTRIPIAAHASSSRTERHLRISLMHTTGRSNSASSCGSGGGGSMRLSTFDRTTLTMPQKLFASQGALLRSLSTQTHISTSGGSHRLAGVRSGTAESPSSAPDLPMFVSTSYSPCSGSAAAAAAGGSGAGDRFLPPQVGKGSTCSWERVRCTPAGTVARPATRHCSTRWHGYNDSRTTRRLSGSLHRPLSNLLDTPGGAPKRVQQTRSSSGAEGRTWSSERCGEGRGRGRDRDRPSRASSGGENISCNRSSAQWKRFVIRPPPLHLCNTSSRRRRHALGSPAAADGHADGDDRAADLHECATSASLLPPPSRQALSWQSPATSSTTTGAAAEGQERDLHSAHVRGTTMVTPVPLPHEDIMHTQNRSTMPLGGANGSKVPRPLSCSHREQGQCHHRHGPHRDWHLRLPRLTLPYGTLGVLLTMATLVVAHVIVQCILSNSLTGRHTYVFSELVLFVEDFTLLPVMSCEVFTSSRSKDPARPSLRDLHWTPPKSITRLLCAVIQFMDLTESVPTLSHASQSPSEPRDEKRCAPLRCDDNLGNLSAVAVPTEQPQPITDGNWEGEHSMLDSSMVCISTNSSSIAFRGDIEAAHVTGTRTGIAGGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJV6</accession>
    <name>A0A088RJV6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Kinesin, putative</fullName>
            <ecNumber evidence="10">5.6.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_110880</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.3" evidence="10"/>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696935.1">
        <property type="nucleotide sequence ID" value="XM_010698633.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22572953"/>
    <dbReference type="KEGG" id="lpan:LPMP_110880"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_110012200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_110880"/>
    <dbReference type="eggNOG" id="KOG0242">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00106">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="25"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="320"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="535"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="904"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="964"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1138"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1193"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1366"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="482"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="657"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="726"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="535"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="578"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="993"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1032"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1138"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1204"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1225"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1243"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="128"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN96282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1490" mass="155856" checksum="AA70BD6E8B1C96BE" modified="2014-11-26" version="1">MSGSPSISSLPLSLAARDEVVIDEGVGIVVRVRPLSTKERADTRVHNCIQCLPDCVIIGGSPPTRASRRAGAAVPTSQPTRATARPYQFSVDHVFNTHASQIEVYEQSCKRIVEGVFHGINGSILAYGATGSGKTHTMFGSTMSAAGIVYQAVQDIFAEKERLEEEEGKRVRIKCSFLEIYNEDVYDLLAKPTGENGGSAKSLANSGTGALGRESKRVPLQVREACGATASASAGFDACESDTNSNGGLHIHGLTHIFPETLEDFARSIEYGHAQRFVAATGANAQSSRSHAIITVEIEVRDGNTCATIGGCGFASSMTEDGDASETNMELSPSKRAAKKKKKPPGSTVTIAKIQFADLAGSERAAATSNTGLRLREGGNINRSLLALGAVVQSLAQQKVRRRQTGGKGGGKMFIPYRGSKLTRVLRSSIGGNCRTQILFCLNPSTKHTEEAVNTLKFAMNAREIQVEAYRNEFAINSSQLAKTQEALIEELREELTRAQSALAAYTGDVGGDDSYNSSGGEGSQSRLANTVLATEGGASSNGSPLMTPTTQQGSLPTTLDSPIVPLSSGDRGRSSPAPTPTVPAVPPWPNRNAQRGTITPSAATAGGGASSLSMNASHTPMSVSGADMPRGSSVPHSSLNCRTARPSVFAENTPLFSELEAKLKNFSAQKESLYHEVREAQERQRDRETQLREQKWRLATFLVSNASGNQAREGVDGNCTTAVGVAGLRKMIAALEAEQAQQADELKVLTKRLDDADRQFAATRQDLLRERQGTSLELLLDNARLRQGCTEAECLAAHYHQECRSLLNRQAEYAEALSKCVEAIQCLCPYLAQLTSLTSSLHSSGNGNAIVAAVKRANVALLYALLPTTSTAQMMAVFEFTLRLTMQSPLLSPALLSVSALSHSPSQTPSFAHPPLAPSPTNRSGGGGSSSSSPLRGGGSSGTRSSNHLASHFRDLMATAESMHLTSSSEQETSDKTEGVRTRHGHLILPTADSSSSPERCPSIQQASKGDGLRGRAPAAGTSGPSKAFRRTGSSTGLTRGTVSPPAGGQKRRSGPGPDKTSLSGLTGEHVLRSTNGVAGGAAPKKNLGGGAPSAHELQRSVTAPLQFGSVVSHSTRAARKPKAVGDLGSATSSLARRHAGTQRVALHRGPQRTPDGNPGGGDADAASPCAFVRSNTASALRANASALHSAGYNLRGRPNHRSGVSSSPPKPTQASAEATGHNGSSRSMPSRSGPAKKKQNSGSRTSGGRLTTSTSSSYPDVDGGQPRAPLHQERRCSGDGVESHLLASALPSASKLRRSNTKTDKLTRFQATTAAGSPSRMARTAGASVQRRLDCAEATAESLTATVIPSRILSSSSDSISQSVSCESGSSGYNRSLDGQIATSGAGTSGKKKAANGALSSPDSTPQLTMARLLECAAATAVPALPQYGAGCSPNTHSSDCANKENGQQLFQLRTRTSFTDDLMVSISTCLSDALSPTSRGQVSSSYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RK44</accession>
    <name>A0A088RK44_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_100750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696798.1">
        <property type="nucleotide sequence ID" value="XM_010698496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RK44"/>
    <dbReference type="GeneID" id="22572812"/>
    <dbReference type="KEGG" id="lpan:LPMP_100750"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100013900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_100750"/>
    <dbReference type="eggNOG" id="ENOG502RNP0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="247084at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="400" mass="45821" checksum="1A80049579190F8E" modified="2014-11-26" version="1">MTTPGASPGGVEYSKKRQDDAEASELRRRTVRRATDAQRAGQEPLQQQEGLSESDKWWPPANQNWSGRMFGSPFDKNKKKLDGMFVPELKEVFSPEKPLELSYEGDNFFINSDFHMADETFEETRRFVPPPSFDPAVDEIDDDGFTDSKVMFDIQAALEEDKKRLEAFGNPMTVEDQVDHLLAPQRDGQENIQQRQEFNGFVHWGLLHGAHLVLEENQDAKRAHEFVNRYMRDIDLFEKWLEHPKVRTHIQKKFGIDMSAKFDKLMALTMAMYTRSKIQVYEDDPAGALKSLTASMSFITEGADLKKERHRKALGAVLVARGMIYCKLKSFHRAEDDLTRALAFVKANRSATLYQLRAEAREALGRIDEARADEERAAQIWEEAEVIRPGMDGAPRKFVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RK91</accession>
    <name>A0A088RK91_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kinetoplastid kinetochore protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_120100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009381">
        <property type="protein sequence ID" value="AIN96338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696991.1">
        <property type="nucleotide sequence ID" value="XM_010698689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RK91"/>
    <dbReference type="GeneID" id="22573016"/>
    <dbReference type="KEGG" id="lpan:LPMP_120100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_120005800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_120100"/>
    <dbReference type="eggNOG" id="ENOG502QTBS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="274987at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN96338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="23001" checksum="9B21D1046EF2B23F" modified="2014-11-26" version="1">MHSVLPYTTNPAQMASIEKLKLINPSSAAATGPYVSVRDPKLVVGGLLHNWDAEAAHALLNAPKSVQTWDLSWTEDETNWEEQVHRCTYPEEVEDLLPAKWIGYCVQSDVDETLARVCKLCTALVNKFISLSQGNNANLSTAKWRQRQALYDRLGAVMELLEASVGEAIPILKLKDPEFIHNCWSQMQDDERVEIMSALGTKEYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RL26</accession>
    <name>A0A088RL26_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_131020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697183.1">
        <property type="nucleotide sequence ID" value="XM_010698881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RL26"/>
    <dbReference type="GeneID" id="22573212"/>
    <dbReference type="KEGG" id="lpan:LPMP_131020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130014800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_131020"/>
    <dbReference type="eggNOG" id="KOG2382">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8119704at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050228">
        <property type="entry name" value="Carboxylesterase_BioH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194">
        <property type="entry name" value="HYDROLASE ALPHA/BETA FOLD FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN LPX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="33"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="411" mass="44563" checksum="F042D87061BD0A6C" modified="2014-11-26" version="1">MQQRGATVRPVNLAKKVFSAKTVCPTAASQLYVAHGLLGNSGNWATALHHLVEHPALRDKLRRAIALDMRNHGNSPHSSDHTNAALASDLEALVLREQQELKRTFHDPSSCTTRHAILIGHSMGGLAVIGTLLRRANEDYLLTSWADHCDDGGTTSSSSYGAWPAEHRRQCAAGMRAVHEEFDFASSQPISKVLFSNCDASSSPSTDSGIASRISPLGRIAGAVIVDITSTMRPLAEYSGSDNIKETLERMTRVRLDAIHSYEEVTAELIRVGIADQAMRNFLTTNIVLGPKDMSKPAQWKCNLPVLASDYGSFLPSITSWFTSSVATGVQASSATAPQPPPRPCTLPVMFVFGSKSPYNDLNYRQQISRFFSNATQVVVDGAGHFVHYEKTKEFANAVAPFIASLISGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RL93</accession>
    <name>A0A088RL93_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_090480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 1">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN95964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704286.1">
        <property type="nucleotide sequence ID" value="XM_010705984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RL93"/>
    <dbReference type="GeneID" id="22572618"/>
    <dbReference type="KEGG" id="lpan:LPMP_090480"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090010000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_090480"/>
    <dbReference type="eggNOG" id="KOG0374">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="256429at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00144">
        <property type="entry name" value="MPP_PPP_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000058">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF489">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="3">
        <location>
            <begin position="419"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN95964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="646" mass="70367" checksum="08EEFC19B04B7433" modified="2014-11-26" version="1">MPSDLMELSREELISYVLDLQSENNALSRQLRSMATKRCSGSSPNQVLPSGSGGVGAVHSDPSMLITASPTAMRRNGSLSIVSEGPLSAAERLSGRVGGLPPAPSFEISMSVIVIENGAALSVPLSSVLDKTYGRQDLRDTDTPVVSSKYLRDTSSFRTQRFSLGSPGATGCAGTDASPSLNIDEECFSSVSPGRLSCALGRGSVLMHGSGAKAGNGGEEVDDEPHPKDPRAGSAGVAVSSLAQRAGVAHLNLRRDLLFARDLSLDADAILTHQTLRLFNQQFARDANMLSPMSSYGNAVYHYIVKTFAVRNGCEHSPDDVEGFGRTLINLCEEAKCILVNEPRHGSVASPCYVFGDLHGNFRDLFYFMDNLISFQDLRYTPHRFVFLGDYVDRGEFSVEVVAYLLSMKVLAPHKVLLLRGNHEDTLVSGDISGYGNTSFRAQCHSTFGAALGEELWHRASEAFAHLPLTANIDNKIYCTHGGIPRYSGGVDDRLDILKSADFPVMESFFQAPENETPQHRMYRQIGMDTCWADPAENESELDMFGFGSNPRGTGVILFGSKAVDDFLDHFHFEYIFRAHQEKSDGLKLSKNARVFTIFSTSAYVGHQNGAGVVLVAEGKIRLIVKTADTYEEEDYVTEEGDGHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLC7</accession>
    <name>A0A088RLC7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cilia- and flagella-associated protein 299</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_090780</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in spermatogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN95994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704316.1">
        <property type="nucleotide sequence ID" value="XM_010706014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLC7"/>
    <dbReference type="GeneID" id="22572648"/>
    <dbReference type="KEGG" id="lpan:LPMP_090780"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090013300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_090780"/>
    <dbReference type="eggNOG" id="ENOG502QSP8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2136125at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027887">
        <property type="entry name" value="DUF4464"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33588">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33588:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14713">
        <property type="entry name" value="DUF4464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN95994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="232" mass="26477" checksum="CAF4F4D3D9E6EB99" modified="2014-11-26" version="1">MAATDRDGGNHNVLDFNTYEDYLDQQVTGEDLFYLEDQDAARRIVELGYKGKDVLSRDEFEAAQQLARTGPLKRRESTEIITSAGKDVSDSPLLTALAKREALVRTGKLATVLFLRDYVGGQEVSAYIDYGHRLRSENFEAYFNKEKKLLPKRSDLSYYNWKTHTLFYNNSPTFQVLADSSLGLVMKHKRDRKAIHVDPSSPSPGENCSRTVVPCKDYLQVVIYDHVTRRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLE6</accession>
    <name>A0A088RLE6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP diphosphohydrolase</fullName>
            <ecNumber evidence="5">3.6.1.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_150030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.5" evidence="5"/>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697381.1">
        <property type="nucleotide sequence ID" value="XM_010699079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLE6"/>
    <dbReference type="GeneID" id="22573419"/>
    <dbReference type="KEGG" id="lpan:LPMP_150030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150005200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_150030"/>
    <dbReference type="eggNOG" id="KOG1385">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6372431at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004050">
        <property type="term" value="F:apyrase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017110">
        <property type="term" value="F:nucleoside diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009134">
        <property type="term" value="P:nucleoside diphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF83">
        <property type="entry name" value="GUANOSINE-DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01238">
        <property type="entry name" value="GDA1_CD39_NTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="201"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN96728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="425" mass="47423" checksum="70E63BA2EB15ED78" modified="2014-11-26" version="1">MRPYSSVRRMTQQSNRLRVIGALVLSAFVLFGFVIYSESPWLSPCNSPYSNVYDIVIDAGSTGSRVHVFQYERSSTGVILLRERFKRIEPGLSSFATDPEGAKQSLAGLLRFAEKAVPQSYQRCTSVTLKATAGLRLLPEADQQVLLDAAQQTLKAFPFQSRGASIVSGAQEGVYGWLTVNYLLNRLDKEGATVATIDMGGASTQVVFETKFTSGEWLPFNYAHQLRTPKRTIAMYQHSYLGLGLNEAKKTLMTLFAKVNGTSSFSCFPRGHTEHLNGVELRNGDSTDFDVCVNLFREHVITKPICRFDACGARGVPQPPLPSKQHPIYAFSYFYDRLYHFRSEGFPVYVSSYKELGREVCQRESADQTTTPKETACMELAYLYSFLTHGLGLSDDRTLEVPNRIEGIAVSWSLGCSLSFVLMME</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLH1</accession>
    <name>A0A088RLH1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleoside triphosphate hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_091240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN96039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704361.1">
        <property type="nucleotide sequence ID" value="XM_010706059.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22572694"/>
    <dbReference type="KEGG" id="lpan:LPMP_091240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090017900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_091240"/>
    <dbReference type="eggNOG" id="KOG1802">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273495at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF495">
        <property type="entry name" value="HELICASE SENATAXIN ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="2">
        <location>
            <begin position="1997"/>
            <end position="2088"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="2">
        <location>
            <begin position="2153"/>
            <end position="2229"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="3">
        <location>
            <begin position="2237"/>
            <end position="2477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1408"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1465"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2117"/>
            <end position="2151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1465"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1489"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="2139"/>
            <end position="2148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN96039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2599" mass="280884" checksum="195FADCDC9404B6D" modified="2014-11-26" version="1">MGELCPPLSLTFLPCRFPPPTPPWQPSPLLVTFRSSPPAETPLETTATGVHTPPLPPFTPSSPLPRHAHRQAPRRCCTHTVKRTGEVIMDAYRLCVQRSSDPSHWPQWVPLVAELNASLPSPPQSPSSPPSNYATSSPSIDEDSREAWMAAVLQYVTQWMVILPRGVSSGATSELNYAETTTSSMSTIDTGRAPLALQPVALLNAMLVSLPTAAASVPQVQQQHQRPASSSHPKEIVEPSSSLSSTNVPELTPIIEDDLTRPPQLMDVVTRLLRHSGWLASGLSHAAGPAPRLPSATLLSHAYQHALLAACSADWVTQPHRACKAEAAADGTTAVKTNHVELTAPLPWTLPPTSRVVSPASGEALHPIAGYRGTLLLLLFHPLRVVRVWARDMLLRLMTCTTPQQGAQASSESSGDSGERALTTLVAFALRLLCTLKHVSVLPAQISFLGHHAHPSSTASASSARLVDPVKYVRQDLVRTVADGIFHLLTVLTAWDKHFEKAVETLTTPSTATANRTAAASLPLLLGRCRATVLLLGGSLVLYGLQGLHQGINRALLEVWRDQQRRHPLNSSACVDPCRASQTAMTQLLDPLNTLLSSNPRMPRANAVSAITIRKVLAKVLVHCLLDNASGLASSKEEEAWRRARLEWLWTFAAALEPPTLRTTAPLQADRAGASALSPADTTDSVVTGYQDSSAINGAGQDDAATGALVLVPGRCAGWLLRPLLKNAAQQLQWEKAMAAARAKPDAGGKASVTDGADDSILVLDKAVYGVSMLLDSLVTTLPRLVCTTYLHDTLAAHESQLLTLAIGGIVHTRSTHALRLHRLLFFADVRAFAAGAAAWEGNETAPTDTAGVPGVCLQRVWLTLPPLIVQLCKSGAVSPAHGGGHAANGTSGGPLPLSETLACLCGMLLVLTDEDAMPCPQWLFMSSAAVMSRAPPPFQWVVQRCMRTMTDMLHEQHELLKRVWLELPSVTTEAVYGAAATAAASRVLAQEKSLLRLLFALRVVAADDAEAGKLAERLAAIFCVGLTSSVARTLSAEAFVWVWRRVVVTQPELRLHPPPPSTASLAAAATAGGSCTAWDLEDAVITNTARMQGNRWLMLLCECSWDQMSEWEVQCGWWMAALLADVVTLDAEQRRALAEQVILTLPTAPMLALSEAAACVMSSTHQAVEIAAEDHRRTTENSEQQLRDRLAEAAQPRRNVVQRLFIQVLRKAEQYPRTSLASVLLRVSDALSPAVTARDVQFQQQVQPLLVQLCSRFPDVQQRINQDGVTWLRRGTEQAMQTMNECLADQERRFRQFELEESTLCREKAEAAQAAATAERLRHANEAKRVAELSRQRGVTRSTAVSKISRNGSGDSAVGLCMGRSLTTVSPHSDQDNAVAGMTTRDPRQQQLFPDQPLAHLAVKRARTPHAGSADTRSAENAPSRPAGSGTSAMIELDVDSDMENVMVAASTVQLLDSLARPPSIPAATPPPPAPTAMSTAKVPKTFPSTTASTTARAAPTRLQHKLQEINACNTHRVHHAEQLRQLQDRLRQVAISTNLLHLQQPLVHDIIGPASQCMAAKVPVLPEVFVSASDGLRRISSDGFAVSAGGTSFNTCISMPLGNAPNEYAVRFAPHIALELRYDIIRNYEDFMDRVCMGSSRCDTNLSHHCRKSAARSPMTAGEEASPSPADRVWSGLLPLHPGIPPVCVAVQNSCAVPHEHNGVTMPDPHSLHFSVQACANPAVDAYLQQQQQQAQGTHSSLQRRTTASPAIYPKFVDAAVIAAAQQGLSAALSEGDVVAVLLPLQAILPTWVERELRRPLSDCPFAELQRRVHEILNTLPHSWRTLGCAAQVCHVQSLSLGGRTAMLCATPSVVERSSGHDGPPSLRFFHVFRMAYDTASSATFYLTKLTSVNASLMELEALHKVDYTRFAATLYDPRSTAPVGVAFYGWATSFLSAAGPSRAMPLIDQLRARLLLQQQLNAWQVRAIAAVLYAVCPGWDDGMAEQSTQAPMPRSPEVLVIEGPPGTGKTQTIASLTLNLLHHLSRTRSGALRLLVCAPSNCGVDEALLRVVRLREQLRVAAPVGVQQPAHAALAGGLLRIGVRDRVDMEVHRLQQPVFFDDVVELHLSSTSATAGGLRRGGRAGDSRGSRNINGHGAGGSGAAGGSAAVRNTVRTHTLESAAIVFSTLGSLHHITRHAQGLAFDVVIVDEASQGTEPAVLQALTLAKSKSVLVGDSRQLQPTVLSWEASRCGLQRSLLVRLLACGHPSFVLRTQYRMHPDIVAFPNEYFYGSKLLTDRSVLARSRASDDPTAATPTIAQKLGGCPRFVFVDVRDSPMERRRGRSLLNRREATAVVDYMRQLRAFFKLTVQEVAAHVGIITFYTAQRNTILSLLTREERHCGVQVATVDSFQGKEKRIILLSCVRTLSAAQLLQLERCAEQGEKERHGDDGDSVVREERSANRRLGRYGLGFLADWHRLNVALTRAQDLCVCFASRDTVHAVGMAAMASAAPSHAVTTVDSSVEEVERQLNADDEDPLALYRMLSHAETHDPTLQPRTTEVVLLDTSADSIEIVDAPATTRSRAACVTHHSKIRLLKELTMRARAAEAQGSRHDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLI2</accession>
    <name>A0A088RLI2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPI-anchored surface protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_150560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697431.1">
        <property type="nucleotide sequence ID" value="XM_010699129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLI2"/>
    <dbReference type="GeneID" id="22573476"/>
    <dbReference type="KEGG" id="lpan:LPMP_150560"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_150560"/>
    <dbReference type="eggNOG" id="ENOG502SM46">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264636at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001838997" description="GPI-anchored surface protein" evidence="2">
        <location>
            <begin position="35"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="35091" checksum="475025191B6EA77D" modified="2014-11-26" version="1">MTSSTSVARPVPMRLGSLLLGVFSLLTAAALTRAADVSYQTDPRALLGCSAYADYFPYMITTTDCPVRDLCITRKRCCKNRNETNLGKCLDITSFSCDTAAMCANYSEGTSRSSSSTNLWYPETQDGGASLMCCQAGTTTTEAPAVPPLDSSSLEEVSQDTDLPPASMCDDTTSTACTVMSMFAPIVRAFCQNPNLSMYTDAYINENVPHMCCLYTAAPLNGNSNESVTAGKVACGSNLLDLPLTGEYHCMLDLRGAAKVCCNGRIEDHLSSSDGTGSAASSGQSRVFTYISHECLFNPDTNGNSAPSPAMSVTQRLTVAVLSVMAAYLCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RM87</accession>
    <name>A0A088RM87_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sucrose-phosphate synthase-like protein</fullName>
            <ecNumber evidence="3">2.4.1.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_160910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.14" evidence="3"/>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN96965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697618.1">
        <property type="nucleotide sequence ID" value="XM_010699316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RM87"/>
    <dbReference type="GeneID" id="22573669"/>
    <dbReference type="KEGG" id="lpan:LPMP_160910"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160013400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_160910"/>
    <dbReference type="eggNOG" id="ENOG502SDT9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="448893at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046524">
        <property type="term" value="F:sucrose-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050194">
        <property type="entry name" value="Glycosyltransferase_grp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45947">
        <property type="entry name" value="SULFOQUINOVOSYL TRANSFERASE SQD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45947:SF3">
        <property type="entry name" value="SULFOQUINOVOSYL TRANSFERASE SQD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="2">
        <location>
            <begin position="280"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="464" mass="52323" checksum="22202348CDF75A5B" modified="2014-11-26" version="1">MTKEWLIFALGTNNWQGSEQFAPGSGILHQGQHVAMNMLNSCHCYSIWPSDLQKTPTDRDDYRVYEIPHPIPICESVGPQSSKRWHSMSDEEVTSYCDTLLKKCIDFIAYIEKKHGKRIDLFLAHHCFMNPVIMSEINERRVAQGIPQVPLVVFAHGTALKMYENEINKLSEFPMKYYDWIRGTKSIFEGTGHVSGVFAVSAQQKSTFEKLFPLFPIERVAITPCGYNQLVFHPMPGMTREKAFGHMPQVLYDGFDATQLSSMQCNVRPGQCIPNVSAYDRVVVFCGRFAHWKRIDSVLKAASMWEKEDKKILTLIFGAGSQETRKLYVDMAYQVLGLKDTFFLGPQSQPDLANIYTVVDLSVFPSHEEPFGLVFIECMGCGTPVIGAKSGGPLDFVSDEVGTLVDEGTNDEVAEGVYAAVKQALVEDWKKIKGPQCEQYALKKFSLTTQAELMLQFVESHFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RN66</accession>
    <name>A0A088RN66_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleolar RNA-associated protein (Nrap)-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_180940</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NRAP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697928.1">
        <property type="nucleotide sequence ID" value="XM_010699626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RN66"/>
    <dbReference type="GeneID" id="22573984"/>
    <dbReference type="KEGG" id="lpan:LPMP_180940"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180012300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_180940"/>
    <dbReference type="eggNOG" id="KOG2054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251401at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005554">
        <property type="entry name" value="NOL6/Upt22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035368">
        <property type="entry name" value="Nrap_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035369">
        <property type="entry name" value="Nrap_D4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035370">
        <property type="entry name" value="Nrap_D5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972">
        <property type="entry name" value="NUCLEOLAR RNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17404">
        <property type="entry name" value="Nrap_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17405">
        <property type="entry name" value="Nrap_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17406">
        <property type="entry name" value="Nrap_D5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Nrap protein" evidence="3">
        <location>
            <begin position="451"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="4">
        <location>
            <begin position="646"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="5">
        <location>
            <begin position="832"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="162"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1149"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1238"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1253"/>
            <end position="1268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU364032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN97275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1268" mass="138296" checksum="4D6DDB08AEED8CC1" modified="2014-11-26" version="1">MALQRYQLSWSDQLMTRVEAHLRDIHSVLHEYYESCGYPTEVETRHVAIIQRAVTGTREESEFATVTAAAPALQLDVVSPVGSFLLRTCVHDTPFPELHAQRGVGADLVLSIPVNRCTAADLKGGLYLERRQSFLHEIQGYLEQLVSGAAKQKSDSSAAAAAVDVAASDTDSDRDSEEGRGASSRSRQHGKVTQGAEKEELNVAAAARLSRVEVRVVPIHGCYALADKQILQLRFRRRRAAAAAAVDAYETFFVNLHFRPSAFPGHAVDMAVVRRHPYYSYCILEDYLMPHYLKKLHEVCIASASVRRAIVVLKCWAHHTGLMSAASGHPEALNGFVVAAIVLRLLEEGIVTAGMSLDNIVRAVWVQLSRGFFLGTPETVGSSAARPVKVPAAEEQGEVSVLRLAGEPHNILFRTSAAFFRHVVGPAAEEALQHPFAVEVVDRIAFQPLPLRYDVALTVQLSQTTTSPVETMDRSPAAIKKSSLWRAPRVEAIQDTLRVLKEALGVRCNYITVWRTDADRLRVVVQLTSEAEGRNRLTRGPPIEDTSAVERFNTFWGTGLTSTRQFSDGAIYRCVLWTFPEDQGTHTTVALSASTVLCRIVEFALRAHVAPEAAVAVLLGGLDGYLAERVGGEWRDAAPLMQRSLLEATKAVQYMLQNLPRGSVPCRIVSLDVIAASERHTEVFPVRPHLALTYTTDDLADASFAGLSTAPTIEPIHCVLNIDDNHKIPDTMEAIAMMKGAIAAQLAKTLQAHYGGKSSSSDVVRSPIRTQCTSQSVDIIYRGYLFRVYVAHYREVSLLRALQRDTEANLLEMKLHWTAQHAKFMRTIAFGHHSYSHAVRLAKRWIGAMYLYEFVQPEAVELLVAHAYLQPAPHTPKTPAGGFLRFLQLLATHDWSTPLVLPFTDDDNDKTAVAAAALVRKLGDQQGMFIATPYAPAASPFTVLTPRLMIMGRLVQLAQSVVAVLLRHLEGHNATAGEVEAFTSSPCAFDFAMKFHPRLVLQPDRALSIGAAAASVASALHEAAPPSGIVLASSEADTLAAEEAAAAANAVIRLWQLDELDADTNGREYINQLVEREPAAHAVRIARAALRERGMMFYDALAPSSLYVVGISAERQVAKSRQLHDAILQVGRGALLPAPPSAFTPVVEVSHSSDAAGHAGFESKDDHRPHVPAHHQGRAAPRLRGAVLHKQSEKAATGALQLPQHHHKRSRSTKDHRGPAAAVAEAAHAKKTKRETAVEASPSTEASPAPAVAKKRSQKMAKATKVHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RN88</accession>
    <name>A0A088RN88_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA-type ATPase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_200350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97527.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698234.1">
        <property type="nucleotide sequence ID" value="XM_010699932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RN88"/>
    <dbReference type="GeneID" id="22574242"/>
    <dbReference type="KEGG" id="lpan:LPMP_200350"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200007300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_200350"/>
    <dbReference type="eggNOG" id="ENOG502S9FR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97527.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="798" mass="88189" checksum="D2A8FADC3C15864B" modified="2026-01-28" version="2">MEISERVEAPFATGSSTSLASLFLAVVVPFLCLRAFAFLYRTWPNVLYRRLTSCFDRQVAAVMERVHPNRLIQDDIMIRSIMGYVSYCYVRAMQCSADACDAVAAADYEYCFLFDKSDMFEEDWVPYSTRFHSLFGRVIASCMELSVVPSSGHSIQVEPGLFVRSLPNKYVTGGDSSENRRPAEEREPNSERANSGRRPSAMAGALNQVDKLNQYLFYSMRKYTEHMDEHPDPCVDGRADEVTSEEGPFGPAAQNNQVRGKNGSDDYGRQSDSTFFNDSQHAPEERIILLEYRRPLPHEHSRALCNSNNTPGGVRDYDVSRTADDVIEAFLGRVHAWYLGHMAHTKRTALMAIYPSTRMANFAKIGAKALKTNISDSDADFSGKYYVLDSAAPASEEATSMAVVSSASSAAEVRTTASESAIVPRLMTTLAGGHVGLRSAAPSSGSRGKTFNSLFFREKARVLSIIDDFVEERGCFGVPGVVPRLTFFLHGAPGTGKTSFVKALARYLRRNLVVVSMSEILTTDELQKILKPFTMEVKQGGQTCSRGTAFLSVSSHQSVYVFEDFDAIGDAWEVLMKVQDQRKKLAEECSLLKTEKLSGDEVTGSDDSDDEKSQVASPSSSAGSRTGDALNSHEDFDDDSGSDGRDMFLLDNDVYEQLARDHLTIERFMDLFNGFNLPDSFIAVFTTNHPERIHPLIRSSTMMDVTLDMGMLDEECATQMVEHYYAIELADETVDGGSRRHLSTPQRTALLVALRAFNAGSNKLSGALLEKMCIECETIAGLTARLSSVNLLDAADVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RND2</accession>
    <name>A0A088RND2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_190030</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697998.1">
        <property type="nucleotide sequence ID" value="XM_010699696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RND2"/>
    <dbReference type="GeneID" id="22574057"/>
    <dbReference type="KEGG" id="lpan:LPMP_190030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320009600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_190030"/>
    <dbReference type="eggNOG" id="KOG0877">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="260777at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000067">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000004">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005711">
        <property type="entry name" value="Ribosomal_uS5_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_uS5_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01020">
        <property type="entry name" value="uS5_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718:SF4">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="RIBOSOMAL S SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="9">
        <location>
            <begin position="91"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN97345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="268" mass="28988" checksum="853A4DA515807615" modified="2014-11-26" version="1">MADNQPAQEAPVTEAPRAERGFGRGRGGRGGRGGRGRGRGGPGEEKEWVPCTKLGRLVKARKVTSLEEIFLFSMPIKEHQIVDTLIVEGQLRDEMMKIYPVQKATSAGQRTRFKAFNVVGDGNGHIGIGARVGKEVSLAIRASMIAAKLNIVPVRRGYWGNKIGEPHTIPMKVTGKCGSVAVRLVPAPRGTGIVAAPVPKKILEFAGVEDVYTSSCGKTRTHGNLIMATFYALRKTYGFLTPDLWADTEPSRDPTDEHAELLAEMTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RND4</accession>
    <name>A0A088RND4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Peroxin-12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">PEX12</name>
        <name evidence="16" type="ORF">LPMP_191110</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698106.1">
        <property type="nucleotide sequence ID" value="XM_010699804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RND4"/>
    <dbReference type="GeneID" id="22574165"/>
    <dbReference type="KEGG" id="lpan:LPMP_191110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190018400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_191110"/>
    <dbReference type="eggNOG" id="KOG0826">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="107372at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16451">
        <property type="entry name" value="mRING_PEX12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017375">
        <property type="entry name" value="PEX12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12888:SF0">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12888">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 12 PEROXIN-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pex N-terminal" evidence="15">
        <location>
            <begin position="221"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AIN97453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="461" mass="50613" checksum="A3D616ACA7C97683" modified="2014-11-26" version="1">MFESNLLSQINTSSPLPTAVEVQFTTSISQSLYKAFQFAHTLLAEKSDRAAALLPWSDEIYLAVSGMLERLMLQHADTTFSEMIFALRRAEIDGPLAAAPLLSTSSTAASGPSSSGLRPGARGRYLRWLLLGPPPVTTPEERAINFINSNVPSQMRVHASAPADAAVAAIASPKAAAPIPLADIIVTDAKAAVGSEVDAAALSQLKSVELLKAEHAPYGYLRFKPLSHRNKIISLFLLTLKPYLERKAEQWYVRNTDASVDAVAMRNAYAYRYPHRAAFLRFLAQYVYPIYHVIKQGSRLLYMMCFLLEMTLYTSPLHRVFGIALRRCTLEDSLTTSPRAQRALLIARVVLLLVFCGFRLLDFTRNADGASSPRQIQEEGLPIPPPPALGGDVPLPEDRSSLPKAGECPVCRRHVTNAAVCLVSGIVGCYPCLQGYVRAQRTCPVTHQSMGVEQIRRVFEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNE1</accession>
    <name>A0A088RNE1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Heat shock protein HslVU, ATPase subunit HslU, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_150090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpX chaperone family. HslU subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697387.1">
        <property type="nucleotide sequence ID" value="XM_010699085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNE1"/>
    <dbReference type="GeneID" id="22573425"/>
    <dbReference type="KEGG" id="lpan:LPMP_150090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150005800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_150090"/>
    <dbReference type="eggNOG" id="KOG0745">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1721884at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009376">
        <property type="term" value="C:HslUV protease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000220">
        <property type="entry name" value="ATP-dependent protease ATPase subunit HslU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001919">
        <property type="entry name" value="ATP-dependent protease ATPase subunit HslU1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050052">
        <property type="entry name" value="ATP-dep_Clp_protease_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004491">
        <property type="entry name" value="HslU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00390">
        <property type="entry name" value="hslU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003544">
        <property type="entry name" value="PRK05201.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102:SF3">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE ATPASE SUBUNIT HSLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="46"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="6">
        <location>
            <begin position="315"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN96734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="423" mass="47551" checksum="230A4DB090B207A6" modified="2014-11-26" version="1">MRPRELMKELDRYIVGQSEAKKAVSVALRNRWRRHQVPSDIREEIAPKNILMIGPTGVGKTEIARRLAKLVDAPFVKVEATKFTEVGFHGRDVESIIEDLYKASLSQTKQNIRRQHEEEAKVKAEDRILKSLAGVSDGFREHLRSGALDDIEVMVELQEKKEKPKTASGEGVFISLDIPSMMGGQRQQTVKKVMKIKDAFPAVLQEELDKMMDTEDVTAEALRACEEDGIVVIDEIDKIVTAAGGYKGHQASAEGVQQDLLPLVEGTTVSTKFNVQVRTDKILFICSGAFHSVKPSDMLAELQGRLPIRVELQQLSKEDFHRIITEPRFNLIAQHKAMMATEGVDLIFEDDALWEIASIAAYINSTVQNIGARRLITITEKVVEEISFEGPERKSEKFVIDAAYVKRAVDKMIKKVDIKKFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNE9</accession>
    <name>A0A088RNE9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_150250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697402.1">
        <property type="nucleotide sequence ID" value="XM_010699100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNE9"/>
    <dbReference type="GeneID" id="22573441"/>
    <dbReference type="KEGG" id="lpan:LPMP_150250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150007500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_150250"/>
    <dbReference type="eggNOG" id="ENOG502SF9T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270259at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="215" mass="23217" checksum="322E1EB7F8DB1CCE" modified="2014-11-26" version="1">MLEKAGLPFRKSLRSAFEAENGLTDIPLLFSIPVDGVTALKTTTHSTNLQVPVVPMLGSIEVSSIAFNTAVGSLQRKVYLFMQRLDCDGKATGPPVPLAVTDTVQFSVPLKLKLFAGDRARLVLYQSGTGLAVSEVILSGCILANADCYFASGRTLVAMSSWTPEPFRFVRDSTMSASRKRSHSPQPMRNQKNCVSSDEPPTLIYAPVFGGDDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPK5</accession>
    <name>A0A088RPK5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory subunit of protein kinase a-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_202550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698457.1">
        <property type="nucleotide sequence ID" value="XM_010700155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPK5"/>
    <dbReference type="GeneID" id="22574464"/>
    <dbReference type="KEGG" id="lpan:LPMP_202550"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200031200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_202550"/>
    <dbReference type="eggNOG" id="KOG1113">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="417078at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034236">
        <property type="term" value="F:protein kinase A catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF152">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="361"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="482"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="642" mass="71163" checksum="0BDB8C9E52079939" modified="2014-11-26" version="1">MSSFDKCVAQLVKRMGDDVPKEVRVKILQNISHSIDDYQHLRDLADAQALMDAEAAKKALEEERCRKLRHQASAPLFSSSMSKTTTPPCVMECASRKHMRLKGMSASRLSRMNASVSTSSKRERPRTVAAASARTTVRPKTYAVQGRSVDFGFSKEISVQLHKLGNRASGKRPSVHRSKPIGTASASASAKPSVGAVSASAPTEVNEPAARQTNSISIERPKRLSPPPLDQTAMKESESVNSTTNGIHEAPRISRSETISYQETFKGFRFGRQDTESGKSTTLEMHSQGGEAEQEAEEAEEFIDDREDERRRTIQMQRPSRGAISDSSLDVDEARIANFPTTPKSQEKVKTISRVLVRHFLFSTLDDSDIAKFASIMDIEEFVAGTKILEKGNANDTFFIVLDGEAEMTIENDGEVVAAPLVRGSTFGDLGLMYEVSNDADVVARVSMQCASLERRTYKMITSRAMEDKRHRYIDFLSSLPVFAGLTSHQLEAVAECLKEDSYVEGQRLIVAGVPNHWMHIVIEGTLRVMAPDAESGDMKEVALLRRGDFAGHIEFLYHHVCVADVVVANAVVKTAKLSRRSFERIPSEARERMIRSVEEDETYAPYHQRMRSATPPPFDTTPPFDAPPSHLLHTMCSHKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPL1</accession>
    <name>A0A088RPL1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_205460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN98037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698744.1">
        <property type="nucleotide sequence ID" value="XM_010700442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPL1"/>
    <dbReference type="GeneID" id="22574758"/>
    <dbReference type="KEGG" id="lpan:LPMP_205460"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200061500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_205460"/>
    <dbReference type="eggNOG" id="ENOG502SJ0A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272440at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036310">
        <property type="entry name" value="Smp-1-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101601">
        <property type="entry name" value="Smp-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="189" mass="20126" checksum="AC29BD98287323AA" modified="2014-11-26" version="1">MGCGSSAQNADAHASNQEVKALSIGMKTRFAAIDPEVLGPYKEDATAKLVFMYGETASIFLLITPPFHKPCPHSNPEGEESSTEEGEKKAPAVEETRWTIFNDSKSDATVEATFFHAEALRAARAHGAAEDAASPVQLEPLDNGRVKAEVAVPAGATVAFVEGPIKGYMWRCSVLDFKTGRFEPAVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQM9</accession>
    <name>A0A088RQM9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_211910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698975.1">
        <property type="nucleotide sequence ID" value="XM_010700673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQM9"/>
    <dbReference type="GeneID" id="22575013"/>
    <dbReference type="KEGG" id="lpan:LPMP_211910"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210023100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_211910"/>
    <dbReference type="eggNOG" id="ENOG502SPWB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="263326at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="136" mass="15101" checksum="0BEF81BC76077508" modified="2014-11-26" version="1">MSASQQSRPLTAEERARSLDVLADLLASTFDAQVSAAEVHRALARGNTAGGDDDNNSWRVSMMKCIHEHNTEVTSEAAQRDSQEWICPMCETVNWSLDARKTLRRQQEETSCRLSRLVTEPLRCECCGYDGTAAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQV9</accession>
    <name>A0A088RQV9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_201020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698301.1">
        <property type="nucleotide sequence ID" value="XM_010699999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQV9"/>
    <dbReference type="GeneID" id="22574309"/>
    <dbReference type="KEGG" id="lpan:LPMP_201020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200014700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201020"/>
    <dbReference type="eggNOG" id="ENOG502SD98">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="263258at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="427"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="616" mass="67308" checksum="8D3A20BDC1680A60" modified="2014-11-26" version="1">MGSSSLSLPSAPCCSCVLGTLPDALRCAVTQGEHGGVTAYLASELPPNSQIWKDSSRGQVGNAYASAESTGTYAVFEDAINCCQWTVELVAASVFGDGDTGDTWWANPEDLAAIDATEAAEPISCVSYQQDGSSGGGCASRITGMRYYMKPDTWRQMFLSRRHETTTTGRIASAVPHSDSAGTAEATRSYPRESSRDAHTHRQATPSALSTVSSVVTATAAEEALSLSTASSPLHDLSLHQLMEQHAALVRRLVQVLAPQRHTISHVIREVCTAAVPSPSSSVKRRVCILSSSDASNAETMQYTESDVAAAIEQLTSSHPRQPRLRELKTDGYLFMNVDGFADGETRHKAVNRAYPALALHWPASGQQMDRMERYVDRDVVLDTRKRHPELSGEKADQTPQRKRDRSLSSAASHAPSEEEDEEHRTGAPGSASAPPSSLLDTAAAPEKTATMATTQRFFQSLREYPKSLEPGNLHVWARGTAAQRAREYLEAAVRLTQRLASTAGAPSDAATLGPLPVTKEEDVAALRNQYDALTASESLLEEKLRAYRDTVHELRGWYHSELCTQQFCYELEAWLQTQEESRAVLTDLYVQVHTARYRLQRDLFDYLHLHALGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RR18</accession>
    <name>A0A088RR18_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MORN repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_221280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699130.1">
        <property type="nucleotide sequence ID" value="XM_010700828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RR18"/>
    <dbReference type="GeneID" id="22575174"/>
    <dbReference type="KEGG" id="lpan:LPMP_221280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220016500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_221280"/>
    <dbReference type="eggNOG" id="KOG0231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270720at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.110.10:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 4-phosphate 5-kinase 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23084:SF263">
        <property type="entry name" value="MORN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23084">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="417" mass="46997" checksum="F3AC78336C2CA51E" modified="2014-11-26" version="1">MAIPKDASRLLLHPLNAQRQQQLAFALSHNEQQLEEFDKQGRLEMLQHQQARRAAWAQASAAAESDMSAVWECVSLAIRDRLTSLQPEGYQTFMFPDGTAIYEGDWKNCHPHGQGCLRRSNPMNDVYEGKWFVGQRCGTGTYHSGEYQFLYQGSWFDDKLHGKGELVEPEGVYTGEFVENTLHGYGEYVYNDGHVYKGDWTCGLYEGNGTYLYPSGAKYEGGWLRGREHGRGTKWFSNGDVYIGEWMHGMPHGHGSLTSTCSTAARVTGEWRYGSLHGQATCVFANGSHYAGEWQRGRFHGRGTYEVPCANGELQRYTGAYANGKRHGYGEYTSSTVSYAGEWVQDKKDGEGSLQVRGGGTYYGRWKADVPEGEGTYVSTYRKGHHDEMHCEARHGTFTACVDQRTQQRVDMRLLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RS66</accession>
    <name>A0A088RS66_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dynein arm light chain, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_240820</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the inner dynein arm light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699422.1">
        <property type="nucleotide sequence ID" value="XM_010701120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RS66"/>
    <dbReference type="GeneID" id="22575491"/>
    <dbReference type="KEGG" id="lpan:LPMP_240820"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240014200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_240820"/>
    <dbReference type="eggNOG" id="KOG4001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273640at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019347">
        <property type="entry name" value="Axonemal_dynein_light_chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13183:SF0">
        <property type="entry name" value="AXONEMAL DYNEIN LIGHT INTERMEDIATE POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13183">
        <property type="entry name" value="AXONEMAL INNER ARM DYNEIN LIGHT CHAIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10211">
        <property type="entry name" value="Ax_dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0243">Dynein</keyword>
    <keyword evidence="3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="157"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN98715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="237" mass="27275" checksum="1A536354C8C6A43F" modified="2014-11-26" version="1">MSATVPSSLVKYETPVLLSEALHKKSLASKRPVANNGKPQPQSEDVLFSILPPREFEKDGQRWVQYPSSTPATRLDVIRLQEQLDTLLAERQARETGVCPIREELYGQVFDELIRQVTISCAERGLLLLRVRDEIRMTLDAYRSLYESSIAFGMRKALHAEQAHVELEARVRALEREKADLQRQVEELVEECAQIEQDEAQRRQDEQKKHDEEVAFFRRTYETLTANLQTVVNPTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTF5</accession>
    <name>A0A088RTF5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="6 16">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">LPMP_261600</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 16">Belongs to the CDS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="6 16"/>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699980.1">
        <property type="nucleotide sequence ID" value="XM_010701678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTF5"/>
    <dbReference type="GeneID" id="22576063"/>
    <dbReference type="KEGG" id="lpan:LPMP_261600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260021500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_261600"/>
    <dbReference type="eggNOG" id="KOG1440">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10260889at2759"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016720">
        <property type="entry name" value="PC_Trfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773:SF8">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, PHOTORECEPTOR-SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01148">
        <property type="entry name" value="CTP_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 16 19" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AIN99273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="430" mass="48823" checksum="8FFCEC0B6AFF9B23" modified="2014-11-26" version="1">MPKEKKERVVLLPLIPTGGNWSPAVDGTMATDKPSTGDVATGTSHPATTSTSAADSKKVGYKDIINRTVFTILMAYVFLGWISVGIRFGLFLLFVIETTMFYEVTRINQRARKERQLPSVLFIKWYFFVVSYIFVSVSCNREPLQNTFAWFEKVYDLLPFVFFCCVMLGLVIFVLSLRKGMYRYQFIQFTWTAMMLMFSQVQFAGEMRNMVRGMIWFLLPVSCVVNNDIWAYIFGKCFGRKKLLSLSPKKTVEGFLGAFLFTVIWSFWFCGFLSYFPQMYCPAVGFTNAVNTQCIRNPVFFQEEVAFPQWVQQVSGGMLKTFLVSPAQKHAIVLGTFASLLAPFGGFFASGLKRAFKLKDFGDLIPGHGGMTDRMDCQGLMGLFTYCYLRTYVFHEVKCPGANDITRCALGMDAKHRQTLVSQLLQSLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTJ1</accession>
    <name>A0A088RTJ1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_262060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700025.1">
        <property type="nucleotide sequence ID" value="XM_010701723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTJ1"/>
    <dbReference type="GeneID" id="22576109"/>
    <dbReference type="KEGG" id="lpan:LPMP_262060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260025300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_262060"/>
    <dbReference type="eggNOG" id="KOG0374">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272731at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00144">
        <property type="entry name" value="MPP_PPP_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="6">
        <location>
            <begin position="400"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="594"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="781"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="627"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="640"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="781"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN99318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1019" mass="111515" checksum="8FBDCABF9F305657" modified="2014-11-26" version="1">MSAHRTKGIGSVVHVEDAAVQFVPLHLQLSTRGGAGVATADEHLYGPHTSTIRVNSYVRCVHDSGVPKIRSLQELLTQKVQPTPAGPDTPCLRPSHGPAEAWAQSPELSSFNDKHVTMTSAHCQIASQCHRDPPFSGAPAACNPSPELFFTADSVATPNTFATVKTHEMRILSRLTKRLRWSERHQDMPCGEPMEMLLVEVGGDEDEDAEEVTEDKDADVFDVVRTDSLDILTPFPGDLFQQQDEAGVQFLPCTTREKAEAASREGAVGCAAGEEAPRPFAVVSSPVAKSSLSPRQVLHSSERIASSHSSTGVCCAFARDPTPADGGKSHVTDVKHAGYSDTSSRHCHYTCEPQREHSQSAVVALRTMYPAPVARLEESPYHYIMRNYVGGTFLYYRTPESKGYFLRLCHRVVAQVRPLLEQETLSPHHGLFPRINAPAFVFGDIHGNFEDLSFFLKRLLIFHDFNLTPANILCLGDYVDRGPFSLECVMLLFSLKIMNASKIVMLRGNHEDRVVCGDLRTYGHSCFLAQCHTVFGYTEGTKLFREVTALFKYLPLAAELVIPSAPNLSFLRSQQTVMHPNLYVSRPALLLHDGDRTRQARPTSSLAPDSATRMPSFDSKPFCTPHRNGEVASGDKESADALSQNSASAAAASPLPPGYSTIADASLAYGQPSRHEAHEERILCAHGGIPRFDRSPLVENALAFLRSLSFPRMLTLFPNNPAVKDDVECMPDYFVKQELEVLWRRYPSAAPPGFTAACRREDAEAAAAAGVATTTTLSVSPSSEALSSTSNRCRMKSSSSVGRSAGNHEIAAAAARLEAETLSRTSLCSVASSLSSTTRSPSALHSEQERCQSHKSLTVARRSSDFLPQLTEGDVRKGWYIMFDLLWSDPTSMELEKEAARADWEVSRDAGAVQDTAGATARRPTAHMHVNEWGFTVNTRGSNVVSFSAKAVDTFLTAYHYSMLFRAHQEKAHGLRWSKSNKVLTIFSSSNYMGHRNGAGCVVVTANGEVQMIEKVVTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTU9</accession>
    <name>A0A088RTU9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L17, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_240040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699346.1">
        <property type="nucleotide sequence ID" value="XM_010701044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTU9"/>
    <dbReference type="GeneID" id="22575413"/>
    <dbReference type="KEGG" id="lpan:LPMP_240040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240005200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_240040"/>
    <dbReference type="eggNOG" id="KOG3353">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="274658at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.10:FF:000016">
        <property type="entry name" value="60S ribosomal protein L17, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_uL22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005721">
        <property type="entry name" value="Ribosomal_uL22_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01038">
        <property type="entry name" value="uL22_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593:SF10">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN98639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="166" mass="19049" checksum="71E9FCB9E9B68200" modified="2014-11-26" version="1">MTHYSRKPQVSSKSAKAKVSDLRCHYKNTFETANVINGMPLRKAQQLYRQVLAKTRCIPFKRYNGKIGRTAQAKEWGQTKGRWPRKSVVAIMSLLKNAEANAIEKGLDPNQMVIKHVQVDQAARMRRRTFRAHGRITPYMCSPCHVQLFMSEKKERVPAPKSAPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTW5</accession>
    <name>A0A088RTW5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_240250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98659.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699366.1">
        <property type="nucleotide sequence ID" value="XM_010701064.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22575434"/>
    <dbReference type="KEGG" id="lpan:LPMP_240250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240007600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_240250"/>
    <dbReference type="eggNOG" id="ENOG502R62I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="278691at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98659.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="3178" mass="354337" checksum="AA14580F5A443FB5" modified="2026-01-28" version="2">MTTDASPVNPYLLFSRADEFSTDAKIDYALRYYHLYDSKGNGTSSLLTSLNAELDRRMLIRTLEELKRGLSLGDRLLPVTPSTCTTANTNVSAFSSLEGGRSPLFDGPNDGEVSNALFDGTDDLDAKPWDTAASSQANYWNWETEVLYQSYHVWIALDYGRGAFSVMRNGVVLVDRMPTIVASLLQVVETTLHAREQDQQLLRNFVEAAIVDEQTRSRVMQQVWNPTVFVSVVLLNVPQEVEKAVPFSPPASSDREVARDDVHRHRQRQQPAIIMCPPELPRFTALGADCGARSRCSAVPVLFHCDARTLLSDSGFMDRLRDLLCRYENVYRAHSTPQEWPQSSLSASLEYLACAMPEKTPECNTLVLVSDGGAMASSDTFTFLENTVRRKNLIVSIVALNRMLVLDSPELTPLTRFLSSVGGFAVHVDYWLALAAHRLNHEWCRKFEGARCVAQQIFVHLIKGFPVTIPGATQRDLFADTMCEPVVLYDGDHGLPDFLIGASTKEVLRATAALRFNQGWSVLIDYQDASATSHMAARYVHDFRRGTIALHYEMNINRPAVYRRLLVSGTKALVDHFCKTRWDDEATNTVGEGTCRWLAYLSLLRAQVMMWMKAEQALLQLVNADPRQRPISAIPDLACLSSAEGVLAQWFNAATVSSLGVFFRFAQLPPSVLMRYTCAQVTNGAQTEAASRACVRAAMERRHRLIGCEEDLTYLHTERMTTSFSGAVNATRDVFSVVQFFPQYETSSSSGFGLAGAFECRVSCVLCDGATQDALVCALLNDIEEAVRERNRATTRKDWHLLVRVSNQAENKQALQLVKASLSTRRGQLPTSYTEETLIPGVDISSAVVRASRLPVAPEKAAHASGVMQFFRDPLSSFPWPLLNALCFRWILGCSEFYPFLVEEIFSHIVARRMHAGFALIVYYTSSLKAVLARRVGTPETHSDVCLFDVLEALPSSAPAPAAQISVQRLITPFKRARASLWMYMRDIQEDLHIATAVFTCKVIATQQHRNRCLLARQMRELGFSPVVARVESILFSLQVRYTEYVELRSPPSLGVKGCVQLRDRLLNIVSCVGDRSTVVKARLLQTDYVQRLSSGADVVDPDTDVYISVLSPMRYETILCVLVLERDTEAGTGRHVVKVALAALDGQLLEYAIAQKYHHCRPSQPARDTATAVGNEEPAETSPSHVAMPECIADRAVVLSLRHLLVAFTSVYCARELISFIQRASPETAASAIAELTNTYAHLGNYAVEMDVTPLLHIVQRRCCEAPGGVPWREKVEEVLTDVLAAQQHSFSVHPTLWLPKLGSDQALQPNETSCIGCSSPDEEADGEEGRVYDDEGESVSGMRGNATSEDDAEEKSAHLDLLPIAVKACMLLLPSASGVCAEENTECRWLSLAVDKCDERWQNTLRDRPKSTISSVSLKDPPVPASASPLEAVDVTTGRLALRLFVKTAPADVLLLCEEESFCPPPKVVRRTLGLLYYHFASEEAPVAVGRSSALLALTFAAAPSYQATADEAALAAVDELFAEPMAVVWNRQRCHDAFYSCTGRSSPPARVKQAIQRITERLKWRIAVYCLQNACYLAPFRQLRARVEAEPAALTAVAGTTIDGAAAVATAERRDDRALETRSRDAVLSHSERMRATELMRNAELQALLCDVVTPALLSSQCFVRDTFSVEFTEQETNVSRVVPEEAIKDVFRHCVEEDWMWVLPTLPLSYVVVPNREHFGERWVVVCVTTKPPHPIGDARILIYDAQRTAAALETMRNYSSHLRTHVCGKIKQVSQLHLLKQLRESFNASAQLIPPGWGDQFSKNSGASDCSDSALHGSPLTCSQDAYATGSPFYLRGRNVLEIPIYYKLQHQCKKILHRIQCHCSRLELVAIFNRDQCFLVADDVEGDTFHYLRLVFVKDTAHTVPVTSRPPPLTSSDRCPQLVVQLFSATPNASVQRPLQRLQDFCYLLAVQELQGHLNYVQHKVISFNDLVFLQNQRLEPIVVNLHTIFDSALSDSGNDAPHESSHDVTAFQERQREVAVTLLFLNLREYKFKPFGIQDEPMHATSNFVEHYNLEKSLTLDPAEDSTPSQGGCNRALRAWRFVKIVDGVTDVLVSCCLHVHPDNPHIIVLDRYLTRIPVERYINGDSENTVLAHLGHSVERTMAQLRFLGLTSPDQSSFPLLRSSIPTTVGELLHISQETPSNDSSLLRHRHFSLENVSPALLPMLMERICGSLSRYGPTCFTYTAERSTKGVVHVPSFSWKWMEGIQNDAMADSMQMYVTCGYDVMDSLAETAPLAPTRVVPYVVPGVPITSVTTGESQMSILGEYQLCERGCPLLEYRIVLSVSLMEGLSLALFNLRDTEYVVRLLGYVVLAMEEKSALLKDVLLQRMGYTIPSFFKEADLACNCCGDDTNVIRTKALSISCDTYRRRVNNVRFRSRPDAEWDEPLVVILEGLYNRGLIVNYVFSVEDAIKVLFDECPQHSLQECVRIVDALLEAHVLCDSPKSALEPQVPIFASLLQAEHLRSDVRNCRLSEVSGVPADALVACGYHRHILASHIIVEAQNARSGVAEVLAKCDVLWRAGPQNNVIELAKAVVTLQLKSKEVFGARVPDFSLRRERWQHEDDVLDPALPTPTQQNVSYARPVDASLQLYVEHLRRLYPSMCIIDLDPNDSLTTSDEVLLNRLRCRYGKVTSEDGGVVLFSPHLYYAVIPFVDLLRCGNFYERYSSLADALGEEAVISPITTSGLFIIEVGFQVVHYALDFFVINGDAVPPGITAKIAAEFKQTLLFESVLYDAAVRRLAYCLRTHSVLLAGQQKLHMAVRNLVKYYPFPPMHCRNIVEAYTITDARVMRLKNLTPSGAANNCELHVDAEGVLYLSPHKNNFLQPEQPSEMYTYSGLITWEWAQLFVLLTSAQNVSKAWRESNHDLSRLALGAKHLLLNQLLDSTQQERLDAAWRKFLTDEHLATAATAGRGNLERDMPSYDEFELLRGHSHKIVLHSYVPMLQMILRPMEWNGDGWRLQALCTQLYPGHVLRVIGLQRSSCEAQKTPTPTPHARYYDLNTGSLAGAVLPKHAAAASPAVGPIGGYDITRLFMSPCLTGWFVVTFASSTAEESGCFLAMECFSDPHRPFGASVVVEELSLYCKPSRAPHQHRIMTFLNEAEQTLVEQFVRLVNSAVWFSILPCVSQFMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUH8</accession>
    <name>A0A088RUH8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GTP binding protein, putative</fullName>
            <ecNumber evidence="5">6.1.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_271810</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.1.1.3" evidence="5"/>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700267.1">
        <property type="nucleotide sequence ID" value="XM_010701965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUH8"/>
    <dbReference type="GeneID" id="22576359"/>
    <dbReference type="KEGG" id="lpan:LPMP_271810"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270026300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_271810"/>
    <dbReference type="eggNOG" id="KOG1491">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="424823at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.300:FF:000004">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="entry name" value="TGS-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00092">
        <property type="entry name" value="redox-regulated ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF18">
        <property type="entry name" value="OBG-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="12"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN99560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="372" mass="41711" checksum="9F07A630EB21B216" modified="2014-11-26" version="1">MLRLSVARWKRRAAGIVGLPNVGKSTLFNALTCSQIAKTGNFPFCTIHANTSRVPVIDERLRQLARFTGAEKIMDVEVDLTDVAGLIAGASKGAGLGNKFLADIRTCAVLLHMVRCFESSKDGFDTPNPLEDIHVILSELVLSDLEVVERRMHKVHKTAKTRDTEYSFLKRLQQWLGEGKTAADMHAEAKLTVVEEDFLQSYDLLSNKPMMFVLNVSERGVRDGNAFSREVEAAFGVERTCRVSASIEEQTAQLASREEQQLFLEEYGIDVPRGQVLMRQVYALLKLQSFFTVGPKMAHGWTVVQGSTARQAAGEIHSDFEKNFVRAKVSAWDMFVSMPNLESAEMQMRMVNDRYVMQDGEVFIVEHNTQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUI6</accession>
    <name>A0A088RUI6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Zinc finger protein kinase-like</fullName>
            <ecNumber evidence="13">2.7.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_281790</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="13"/>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700519.1">
        <property type="nucleotide sequence ID" value="XM_010702217.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22576624"/>
    <dbReference type="KEGG" id="lpan:LPMP_281790"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280024300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_281790"/>
    <dbReference type="eggNOG" id="KOG0690">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272861at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05123">
        <property type="entry name" value="STKc_AGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024311">
        <property type="entry name" value="Lipocalin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045270">
        <property type="entry name" value="STKc_AGC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13924">
        <property type="entry name" value="Lipocalin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PX" evidence="11">
        <location>
            <begin position="111"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="628"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="12">
        <location>
            <begin position="909"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="13"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="287"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="491"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1174"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1186"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1224"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="657"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIN99812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1297" mass="140337" checksum="95D6EB8B80D9FB3C" modified="2014-11-26" version="1">MFYGLFLRPYTARSAPASSGSHASGDNGTSTVPVGPSELHNDNASPGAFGLDGVVGATALQHSNDTAVPAAAHGGDRRAFEGEERLLEHPHAPRQYPLDPGKDADVLVLLAQQYSITSVVITHYRVKENYVEYVIECVRGHYAWRVYRRYQQFKALDHDLKQLCSSRHGSSHGAYGVVPVLPGSHWMDVTNQSPELVEQRRRYLEIYLQQLLVPKNLFYVARTQLYDFLHDGEVPTHLRLTGIQPLLGLMSTCTDLVSDEGDNEANCHEQQEPTSVTEGAVAAVSGTGENSALPLPTSDSTFPALPADCESPTRVTSGASSPEAPGNAKGEVSSRRASDATAVATSSIPGHTVALAPSRGPSTLLTTSEACTDVRKTSVAAVDDADDDGEANSLKGQSENAHDTNEVMLVEQSLHSLACGAAFMGAYTTPVSFADERLPPASANCAQCNAEFTSFLYPCRCFFCLVQFCSACLQKLAVLESASATAADRINSVRDSVPEKAPSSADAKGAGSGVPACRQCAENYIRRLDRCGTAPGSGFYRGMQSTFGTPAQSGSPVPPGRLSQLSLAAGSSLTINTRSCVGEENGQVMQQQRVINSTSPIPHSSLLSPRGSLVSRSDNLSPVGLQDFQLLTVIGRGTFGKVLKVQLRATHKVYAMKIMNKATVYRRCMTSYMKEEKTILTSMHPNPYIVRCHYAFQTEYYLVLVMDYLPGGELYDYIYPTLRLSPEAARIYAAELVLALECLHRQDVVHRDLKPENVVLTADGHICLTDFGLARRSFSHSRRRSFVGSPEYVAPEMIQGEVQTAAVDWWSFGVMLYEMLAGRTPFHARNNNTVYDNVLHNELELPVLRADDSAGAAVATASQSAVAEGSPTFRGFSPDAASLLTGLLARDPSMRLQDASAIKQHPFFRGVNWEDLWHRRMPAPCIPGDMRDNDVRHFKREFVSEWASVPPLTNMTRASIEALTKCFNNFPLSRTAAPAGSALVESTSTISTSPASGTPLPATHSPQQLYRGARVSSPSLAPPLSVLVTDSRMAREPVRFFHSMTEAQRHFHGVWRVVSIEVHAVDDGRVIFPWGGNVSGILVYTSDSRFSLQLTPSTRLPIGPVQRVTQLSKEDLCDTYCSYVAVFGHFHLAPSSMDDGCGVVQHFAEGHLCPNLMFVNTVFEYRTDTEPLYPSAITNESKNKGGSKPTGATSSAATTAASACTSSMTGAEDGSGGGSLSGSEGERGKGEKSGEKTTVFGYADQQHDEGSASTTGRPPPSPPVPERRILLRLSTRPQRVPEHDFLAFTSLVFEKVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RV06</accession>
    <name>A0A088RV06_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_252310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699801.1">
        <property type="nucleotide sequence ID" value="XM_010701499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RV06"/>
    <dbReference type="GeneID" id="22575879"/>
    <dbReference type="KEGG" id="lpan:LPMP_252310"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250025200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_252310"/>
    <dbReference type="eggNOG" id="ENOG502QUAN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276167at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058392">
        <property type="entry name" value="DUF8079"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057419">
        <property type="entry name" value="PH-like_2_kinetoplastida"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26290">
        <property type="entry name" value="DUF8079"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25405">
        <property type="entry name" value="PH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH-like" evidence="3">
        <location>
            <begin position="269"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="384"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="507"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN99094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="642" mass="71701" checksum="6128F4E50E424687" modified="2014-11-26" version="1">MPRQPTKNRINMHDIVEQPLSAIPDAVDAVLRRPEPLDELEVQSIFFESSYILLRAEEALSAKDGNAFCALFKIFSEGFAHSEASFEEGIRTVVQNDSLLQTMHSIFKVVVEQEALPLHSAGTVELIQVLSSLCDGAALKDKCGAVFMRGFAKVLQRAYSNAEEARRHFHVQRGTATALINLVKGSKQNKQRLASWKFVADCCAASVDVFFQLQCVELLFRVSRQNKDVFSHLGGSLPLATIEELRALPNDGTLLSRMTLLIEHLNEGRAQVLRYPLKEVVAAETTLTSSTNAYFTPNYVIVMVTTANADNITIPYRIIRSITLGRDGRVIVRLEEFPVKLELLLSRTAGMDTVTFYMAQEDLATFKQSPVRQWIVEALQARKEEQHHHLPPQAPRSPDSTAKPAGKVEWATHKPLSSTATAASGAAAAAPCEASGDIDTARKKARLESATTAAVVPYTNQPPIGALLHGVDALIEQAATPNEAQAMLLQLRRLMEARKEVQRGKSLDDLSDAMQRIQSRVDETRRTAKENRAAWHQAMLEELERVEALVVGAQDKAAAGVEQLNDHLKKVKASNQAINERIACMDVELQRTLEELREEERRWTSEIHTKCMREAERLEFEVDQQLLNRSRPMTLLSDYMRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RV42</accession>
    <name>A0A088RV42_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cysteine peptidase C (CPC)</fullName>
            <ecNumber evidence="4">3.4.22.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_290820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Thiol protease which is required for parasite excystation and invasion of the proximal small intestine of the human host.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.-" evidence="4"/>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700690.1">
        <property type="nucleotide sequence ID" value="XM_010702388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RV42"/>
    <dbReference type="MEROPS" id="C01.098"/>
    <dbReference type="GeneID" id="22576846"/>
    <dbReference type="KEGG" id="lpan:LPMP_290820"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290012400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_290820"/>
    <dbReference type="eggNOG" id="KOG1543">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="640249at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02620">
        <property type="entry name" value="Peptidase_C1A_CathepsinB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000096">
        <property type="entry name" value="Cathepsin B-like cysteine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="3">
        <location>
            <begin position="98"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00060028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO00033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="340" mass="37278" checksum="518E4C033C7778A5" modified="2014-11-26" version="1">MRCYTKFLLLVAVVLVVLLATTLSTLYVVPRNTPLLSNRFVAEINLKAKGQWTASADNGHLVSGKSDEELRKLMGVLNMSTAALSPRIFSAEELAQELPTSFDSSDKWPKCRTISEIRDQSNCGSCWAIAAVEAMSDRYCTVAGITDLRVSTGHLLSCCFVCGMGCQGGIPTMAWLWWVWVGLTSEVCQPYPFPPCGHHTDGGKYPACPSTIYDTPTCNSTCTDPHTALTKHKGEKSYSLRGEREYMIELMTYGPFEVALDVYADFVSYKSGVYSHTTGDRLGGHAVKLVGWGVQNGTPYWKIANSWNSDWGDNGYFLIRRGTDECGIESTGVAGLPSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RV46</accession>
    <name>A0A088RV46_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Haloacid dehalogenase-like hydrolase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_281470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the HAD-like hydrolase superfamily. Cof family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700487.1">
        <property type="nucleotide sequence ID" value="XM_010702185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RV46"/>
    <dbReference type="GeneID" id="22576592"/>
    <dbReference type="KEGG" id="lpan:LPMP_281470"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280020700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_281470"/>
    <dbReference type="eggNOG" id="ENOG502S29Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27226at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07516">
        <property type="entry name" value="HAD_Pase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47267">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47267:SF4">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE PHOSPHATASE YIGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01228">
        <property type="entry name" value="COF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01229">
        <property type="entry name" value="COF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN99780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="402" mass="44345" checksum="D2B4B8B214E3535D" modified="2014-11-26" version="1">MANSEHVVASTVYARKPKGVRVPTGLNPYKLVACDMDGTLLNSRHSISDYTRTVLSQLLARGVHIIFATGRPFTDVYRIKRRLNIFAAAKSIPTPGFQVVTPVAASPASRYPSGSTSSSCNSGLPPSPSSACSGTEFNNTEKIIPRCFAITSNGACIYNEVNERIYERTIDPHIVQELYLMFMDDPEVNINVFRGVDEADRQQKGYINPSDQPGDKASEEWICRYPSDLEAALYKESRFTFRVVSNLEKTFPVDHVSEIFFLCYNPEKSSMVESGINKRMAELTQELSLETSVRVAPSATHCLDIVPSDVSKASALQHVLDKLGLTMDDCIAFGDGLNDVELLSSVGKGIIMANAHPRLKEKLPHLEVIGRNDDDAVAHKLSEVFDIDVECDYMDTPLKSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RV67</accession>
    <name>A0A088RV67_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_281770</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700517.1">
        <property type="nucleotide sequence ID" value="XM_010702215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RV67"/>
    <dbReference type="GeneID" id="22576622"/>
    <dbReference type="KEGG" id="lpan:LPMP_281770"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280024100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_281770"/>
    <dbReference type="eggNOG" id="ENOG502S1UA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="252503at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF98">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="269"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="424"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="570"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="275"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="291"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="351"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="456"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="579"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="629"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="711"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN99810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="847" mass="91182" checksum="3FBE9EF2BD06BA3C" modified="2014-11-26" version="1">MIRKKVLSISGNSATLLVQDTEAGGALRVLRRMNVAGWTDAEVSAAVRMYEELHKCRLRGFVPIHTILIQSSFLSVVASYASEGDVTALIEEDEQNSFEEISVLRWLCACALAIRQLHLHNLFFPGLTSDRLLLDHHTGGTANILLGVPLPLPVYYAQLQERRKSGVRIALDYPPEVLAAPAAHLSSGEGTSNITKGGVGYHPTLSDVWCLGRLGVVLLTARGTNMARRSGSTRQLLSRMMADEPATRPSMESIVQSLVALAGKVSLGQPPWPAEPATTPSTTSAQTTPVSPTPAMPSRQPPASAPGSTGWSAGTVAQQAAVANSSVGGGGSKPKGVMKAASQRSAPDHPPNTTKSSSSPDVPATHAHNSQLSSAGAPVALAHSSPPPPIPAPTPYLDHSSSLASTSSDSWHRRAGEKFELLQRMNASPPKQHTFRSGEASLGSSRGEHGHHRIRGSTSRLLNRKSLSPRRNSRGGYLDHNTRMLDEMFAEQGGLRLQARSWHPSPQGRVEDPKQFQREALRQLRLETAARQQEMRKHFTEWQRQNNQRLTDADNVEVIDQDGIVIVAPRPAPPHEFLPTATAEPAAEGGESNTGMESLKSKPQPMEDAQSEAEPRQTPLPASLPPPNSTSRSTTPRTKTPPGGSTSAAAGSAQSTWYSGNEPRASYLSMSTQAEPGARDTGFSALPLHNPTSPRLSPLPSAVQLYPLRSSDPSGKGTSPPSDGSERPTHRTGGGRRLLWNNSSDVGTLSAVEWTVDGIRSTLRMLLRNRDLYGETMQEVALFIRQPEEARLAARANEVFMKRLRELLHDDAVFFGVAPLCAQLAALEGLNNTLRGSSGDHPSRQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RV92</accession>
    <name>A0A088RV92_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LPMP_260300</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="11"/>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699851.1">
        <property type="nucleotide sequence ID" value="XM_010701549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RV92"/>
    <dbReference type="GeneID" id="22575933"/>
    <dbReference type="KEGG" id="lpan:LPMP_260300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260007800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_260300"/>
    <dbReference type="eggNOG" id="KOG1046">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275509at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000006">
        <property type="entry name" value="Puromycin-sensitive aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF174">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 11 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="14">
        <location>
            <begin position="14"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="12">
        <location>
            <begin position="248"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="13">
        <location>
            <begin position="542"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AIN99144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="877" mass="96794" checksum="EE8C9DC1012A12B7" modified="2014-11-26" version="1">MTTARCVLPRNVRPTHYHIAISPDLEHATFSAEVTIDVRIAEPTNSFTLNAVGLTFSDVSVRATVGGGAPVTVQSIMESTEDQRISVQVDCAVADAAQLRFCYTAAITDNLFAFYRSHYTYEGVTSYVGATQMCPAEARRVFPCWDEPAIKATFALDITVPAKLQVWSNDAPLEVVQLPDGLARWVFRPAIAMSTYLVAWVIGELDTAEVTAPRSAAAVAGQGGALASPSSIVIRAITPRGKIEQAQFALTVAAQVLPLYETYFQSPYIFSKLDLIALPNFAFGAMENWGCITFREQTLLASAEASATQKERVAMVVAHELAHQWFGNLVTMAWWSDLWLNESFATYMAMWAVSKIFPEWVVDTQFVYNEGSGAFQLDAMRSSHPIELPVVDVQEVDSIFDAISYSKGAMVLRMAAKFVGEAGFQRGLVNYLSRYAYAAATSVQLWDALSGPAAPNLKGVLHNWTREQGYPYVQAVHDAEASTLTLTQRRFLVLNDATPAEDAALWKVPMYYTYGTGDGEVNTVPIVLADRTVTVPIDGAVWVKVNSDQIAFCRVQYTEAMLRGLVGPLSTKLINGTDRYSLLADYAAFARGGYCDTVQAMELLSHYHSEEDYTVWCEVAHFEKNLRSILGGCLPEVRAAFNDFCDRLYAPAMQRLGLQPRHDDGHRTQQSRLLIFSRLLACSNAETVAVAQELYDNRATSSISLDMLGCVYSVHIHTHGAAAMAEVQELIAKATYAEERAQYLGALAAVAEPSTDVPRLMDYLLSDAVNSQDMLTVLLGLAEGAQTQRVFVEQLIHKWPLLSQKAPSVLLARMLKLLEHCSDEAMVTPLRRFFDCMPGEMQSRTRMAFEQGVEGLRCNAAWVARDGAKIARYLLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVH7</accession>
    <name>A0A088RVH7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heat shock 70 kDa protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_282930</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700632.1">
        <property type="nucleotide sequence ID" value="XM_010702330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVH7"/>
    <dbReference type="SMR" id="A0A088RVH7"/>
    <dbReference type="GeneID" id="22576738"/>
    <dbReference type="KEGG" id="lpan:LPMP_282930"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280035900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_282930"/>
    <dbReference type="eggNOG" id="KOG0101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="242658at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10233">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000055">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="617"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="617"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN99925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="654" mass="71302" checksum="17158A359508D667" modified="2014-11-26" version="1">MTFEGAIGIDLGTTYSCVGVWQNERVEIIANDQGNRTTPSYVAFTDSERLIGDAAKNQVAMNPHNTVFDAKRLIGRKYGDPVVQADMKHWPFKVKTKGDDKPVISVQYCNEEKIFTPEEISSMVLLKMKETAEAYLGKQVKKAVVTVPAYFNDSQRQATKDAGTIAGLEVLRIINEPTAAAIAYGLDKGDDGKERNVLIFDLGGGTFDVTLLTIDGGIFEVKATNGDTHLGGEDFDNRLVTFFTEEFKRKNKGKDLSSSHRALRRLRTACERAKRTLSSATQATIEIDALFDNVDFQANITRARFEELCGDLFRSTMQPVERVLQDAKMDKRSVHDVVLVGGSTRIPKVQSLVSDFFGGKELNKSINPDEAVAYGAAVQAFILTGGKSKQTEGLLLLDVTPLTLGIETAGGVMTALIKRNTTIPTKKSQIFSTYADNQPGVHIQVFEGERAMTKDCHLLGTFDLSGIPPAPRGVPQIEVTFDLDANGILNVSAEEKGTGKRNHITITNDKGRLSKDEIERMVNDASKYEQADKMQRERVEAKNGLENYAYSMKNTIADTNVSGKLEESDRTALNSAIDAALEWLNSNQEASKEEYEHRQKELESTCNPIMTKMYQSMGGGAGGMPGGMPDMSGMGAGAGPAAGASSGPKVEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVN9</accession>
    <name>A0A088RVN9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_291340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700741.1">
        <property type="nucleotide sequence ID" value="XM_010702439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVN9"/>
    <dbReference type="GeneID" id="22576898"/>
    <dbReference type="KEGG" id="lpan:LPMP_291340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290017700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_291340"/>
    <dbReference type="eggNOG" id="ENOG502QVRE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="238526at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO00084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="296" mass="34013" checksum="684AD5D2BFBB07D5" modified="2014-11-26" version="1">MAGAAWASLGNEFKSVAEEKFLKPVPDQFLTPRATTDVQPAEELLSKLVEENAERYKGIDVRDPSSMAIYEGERPRWMTMGGQVRAVSEFISGHLCHHISLSEWKDLFDLEYAEMDLTYWLYVLHIHLVSRRATSIPIERFNRRREVLEELLVTMFDGWAATSEDIMGRPPLNKIKYYIRDMYYVTAVNFEEALLHDGPGADMMLVGFLMKFCPLPRPEDVPMFTYYTLVHYVRFHTALFDRIPDEEFAKGNFNFLSPTDPLIFSQYSDIAYDEVIRGWTVEEGKGSAASPAPSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RW05</accession>
    <name>A0A088RW05_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Reductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_270720</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700161.1">
        <property type="nucleotide sequence ID" value="XM_010701859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RW05"/>
    <dbReference type="GeneID" id="22576248"/>
    <dbReference type="KEGG" id="lpan:LPMP_270720"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270014100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_270720"/>
    <dbReference type="eggNOG" id="KOG0534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004128">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF179">
        <property type="entry name" value="B5 REDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0274">FAD</keyword>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase FAD/NAD(P)-binding" evidence="6">
        <location>
            <begin position="35"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="1"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN99454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="200" mass="22842" checksum="4C040E0164B8CDE8" modified="2014-11-26" version="1">MTNHLFGMHVGDTLLFRSVAFKIQYRPNRWKHVGMIGGGTGFTPFLQLIRHALMERSDSTEVDETKLSFLFCNRTERHILLGGVFDDLARRYPDRFRMFYTIDLAVDKEKWLERENHFLGYVTTDMICRSMPAPEEKKKIVMLCGPDPLLSHVAGTPISTMSSMSGSLNIQPMATDINNLVSLGGLLKELGYDNTDVYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RW21</accession>
    <name>A0A088RW21_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_301280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701158.1">
        <property type="nucleotide sequence ID" value="XM_010702856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RW21"/>
    <dbReference type="GeneID" id="22577182"/>
    <dbReference type="KEGG" id="lpan:LPMP_301280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300017800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_301280"/>
    <dbReference type="eggNOG" id="KOG2231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3838338at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057634">
        <property type="entry name" value="PAH_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044288">
        <property type="entry name" value="ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938">
        <property type="entry name" value="ZINC FINGER PROTEIN 598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23202">
        <property type="entry name" value="PAH_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="34"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="541"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="694"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="541"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="561"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="571"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="605"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="632"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="669"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO00358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="725" mass="79561" checksum="1211C7D1ADA90751" modified="2014-11-26" version="1">MSGRRNRNQAEGGGGCCNAAGGLSSDDKEVPVECLICADPCRALCVFQCGHYTCYSCGLRIHSVNKGSCPVCRKEATEMPIITQKVSREEEQFSAEEVASMRRVVTTDHYLRCVIDSPQLACEMAKLYEYTCPIESCWCQGYQDPFLKINVLKDHLWVDHELMYCEVCLQHRPAFLCEQVAYSSTALQHHMEGRCRHDRSSFTGHPPCRFCKRTNRFYDGESLLKHMQQQHYTCDVCNRGQFTFTFYASRQKLDQHFQMCHKICDHPDCSSLDLMMRVFGNEIDLMVHKQRVHGVKAKVTFSPAMFGEASGAPAGSGSTGTAPATASNANVIQITFDHIFRVETVAMMPTKENCHGGGRHGGGGGGGQRSVDTVHAPEENGIPLYYLHSDTLPILTRPVASDVGTASISARSGGAWRNDTRSDPSFSAFAIAEDMRNYNVRNKLPTDRKQIEQRLNDMLSKHLRSPVAYAQFRSYTRDFMESAMLTSKYYDVLARECFPNPQVFHGVFPLIVATVPVAAKQAALQEVHKMRMAPEMQRIARAREEDARKEAEARTAAASAEEVRNCKAEKNNSNTNGGNKKSAPAGAPSPFGRKNAKGEGGRQNAWLTTDTRSKFGVSSSAPAQHQDPFLNAHATSPTTLAPSAAASLKSNSNSGPRAWGSATVTSLGPSSTTPAAASAPVSTAVHVGGGLVINEETFPSLPNNGIRRDPISKAQRAKPNAWFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RW72</accession>
    <name>A0A088RW72_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Succinyl-coa:3-ketoacid-coenzyme a transferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_301880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00413.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701213.1">
        <property type="nucleotide sequence ID" value="XM_010702911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RW72"/>
    <dbReference type="GeneID" id="22577241"/>
    <dbReference type="KEGG" id="lpan:LPMP_301880"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300022500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_301880"/>
    <dbReference type="eggNOG" id="KOG3822">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1933379at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707:SF60">
        <property type="entry name" value="ACETATE COA-TRANSFERASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00413.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="432" mass="46787" checksum="E9A291C84B487136" modified="2026-01-28" version="2">MHSDIGPLARDRQIAKVITSYVGENSVLAERLLNGEFEIEFCPMGTLVDRLRAAGAGLPAFYTPTGYGTAVSEGRLPVRFVPGNPMRVAEYSHPRETRQFGGRWCTLETALPADFALVRAWKADKRGNLVFRGTTQNFNLACAKASKVCIAEVEEIVECGELDPKTVHLPGVYVHRLVCPPSIRRAAEFVVERKAGLSSGTGKDALAARNIIARRAALEIKDGMTLNLGIGIPNLVVNYIPHEMDVVLQGENGLLGIGPYPLPEEVDPDVTNAGKQTVTMSKSGASLFDSAESFSMIRGGHLDLTMLGALQVSSSGDIASWWVPGKVLRAAMASEASGGGGVAVCCCLCARVGERSVGRLSPFFFCFVLSFSTQSLCPCHLFWERQLTASCSEEMALFSFSSPWWCVLSVPVLRCTAFDLAFCFSFRVVCRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RW87</accession>
    <name>A0A088RW87_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_291990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700803.1">
        <property type="nucleotide sequence ID" value="XM_010702501.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22576962"/>
    <dbReference type="KEGG" id="lpan:LPMP_291990"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290022100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_291990"/>
    <dbReference type="eggNOG" id="ENOG502S6KD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273609at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="264"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="517"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="726"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1430"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="190"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="819"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1543"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1612"/>
            <end position="1646"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1791"/>
            <end position="1839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="522"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="726"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1968" mass="216153" checksum="5F92BCEA6177F5B7" modified="2014-11-26" version="1">MNAATTAVNPSMRSARRDRSPRVVVALTERAKQRHTARLLGRSNELLQATRAFSVWVAAIRERRLQTHLKRCSTMLKYHSLRQGYSRYFMQWLAFTQTRTSESMRSAIRLRQDVPLRSKADFLHLARRYFAKWRLKLRERNQRTVTNVELLEALNKERLRSRMLLKWWSFHNAQTAKHHAIEILERENAILDLQQELQKTAQATKSLRNQLDSALQQQSRLQNDLEATRDDLGASKQQHETEVNELREAMRQAVKLMEGSSSLRLHSLQESDPTAANPCSTSGASTPLPSLLQSSKKLLESARQSKHTAETLLHAVGDTLASLTLVAKMPTPPASLKECVAHLGNRLSEEAREAATIKAQRDELALAAQTTRATLAAASPLLRVDSAADSGGESSREPSLITSPIRCGFNISGRQSALRISGGGRRSGAPAVTFGHSSSAASVVNGATPSLSSRSASPAERSLIDFQKLSRLLIEDAKAVVGAMQVVHQDGRRSTNEVKDLQDAALRAIDALGGRGATNTDFMEKSQESDEDRASRSANIADSLRNLCEDMVVVLVLTSLWSGRGASERVSEALERLWHRTQDLEAAHADYRQQLEQYAMVVHTTVAILRPPPAIQQLTMSQRTAALLARRRTSAPPDDAMATPEQVDVARRIAEKLADKGDRRPTELLELCLQAQQRAAAEQSSVPENELDGLVKSAHEIIAVVVGKTHSRELGVELSLESASQRSRLSRSAALPETSDSAAEAEVSQSRSVDPPTAKVVATTLKAVAAVAAETLRRTDGVADSSLLDALACSWEQVDQLQEQLKALAASEQRNAEGKKRLQMELKEAVQQSKASENIFKQHLDDLEKARGAAERDLHQQVKALQREAAQRAQDCKKLEVELEGLEEDNRAKDLALHAQTEALEKERREHAEKIRRLREEVESLQSQLAAAEVENSLSGEANEVLHRRLVDQQRKQLNYDAAVAEFEGKLRFAHETIETAAAARQELTAQLLAVEEENRTNIAIGVFLRDVLRDCLTRLHHMTRNLGDTAASEPSPRASLTLREAHERPPPILTCDSNPSEYVEYILQLDGNNSTGKQLVQEHLRENVVLHGLRALCVDGGAAGTSEAESRAASAGRSVSFDDADPSTWEVLAELHDRFVILYDRIAQMDKSAAEQRAHLDALTAVNDQLTADVLAGLVELQPWLSVAAVASQEEHHTALSPGANGAGSPPHTPALRAACAEVAQALEAMRKVAALAQPLMEMRSSGSPPRRANISGPLNIPGTDAAATKRLLSLVADVQDMADCLQHLSESVIHGILALGGTPDEAALNTTNGMAHPHNASSPMATAATNGGAAKHHSQIGVQSGCVDSHLLAARLEAICKETGTSVQEVKQLMDAVDGANNASSASSMPGSSRMVRLSDMLPFIRSKMQELQAVKRESEQMLTGLDRAFKDDDDDSISTSMSSTQRSLKPKQKPLPAFQGTPESGLCLMQQEMKSCRKKASRRPGDFASVLQDTKATVRERIGDLQNLCLASRSLLQVLEGRFLKDDKAEQPPRYGEALVALLTTQIEDLKQALPETEEALAGYRSSLLNVTVGTRLHLLCSVVCSLKLERDSLKEDLARHGRQGNMLLNDFSKEAKLLRAEIARLQEEKERLARAKTSASDEVEAQKCNVAELAATLTSFQQERNVLCEALAHSLRGLPGTPYRRVPLVSVQENLLAALTKEQGKPLTVSVEAALRSSDAHQQRLQDILHGSLGELRCGMAVLRTQVENCWDLYGRPMVNAAAQQFMEATEVLALENNMLRPRAIEREKLVRGKAELEAALADAEEARADVVARLERADDENTQLRRALRDAQMAQALTNGDDNEEDKNKWNQRSGQLLRTHSVEWERRMIDGATELTMNAVNSMSGTSMSAVFGSVVEETLRIYAGVRRSVQGIEAAYVASRGKDDHHVQAEVEQRLQELRTLSESANYLSARLPVLYREPYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWY5</accession>
    <name>A0A088RWY5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_281310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700471.1">
        <property type="nucleotide sequence ID" value="XM_010702169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWY5"/>
    <dbReference type="GeneID" id="22576576"/>
    <dbReference type="KEGG" id="lpan:LPMP_281310"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280019100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_281310"/>
    <dbReference type="eggNOG" id="ENOG502SA7K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="240081at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="444"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="470" mass="50446" checksum="96AC1B72CC1736E9" modified="2014-11-26" version="1">MSTSATAPVGKWVIVRSDRLVVSVDKTNHTYFLGRGRQLPAAQLLSHKYASREHLAMVWHPPHLCMVQVGKNPSFLGASCTPVPRLRGDATTTESEENSPPLWQRAQVRFRATAAVKEATAHQSAGDVITVDVPLSDPLTVTHAPDRHWIGAATVHFPDELGLPTLTVRFEETETTREDATAAVTTKTTAEMLTVPLARAVGGDDDDDDDGLSDGEKRAGLSSQGRTRADEGAAADDGSGKPEWRGLLDVALQQQQQREGTSVSSPAAQAYEARPASQHVPAAFAPSTKVSVGSVADKTPPPSAAAADPAPHRVGLWEWKNHGKGKDNGATSWSKYNLAVAQLLEEAYRDASIATIKIPDSAMFGKAEARGYTYGVCFAEKALDGAMIQYSLELPGNFCLIRRTGGPPVDRRRAKKAHVIPTPPSSEDEESDGEADSSDDSYSEESVSSSSSSSSISTDGTPQWKKRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RX01</accession>
    <name>A0A088RX01_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_310590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701448.1">
        <property type="nucleotide sequence ID" value="XM_010703146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RX01"/>
    <dbReference type="GeneID" id="22577485"/>
    <dbReference type="KEGG" id="lpan:LPMP_310590"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310011100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_310590"/>
    <dbReference type="eggNOG" id="ENOG502SBFP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="240601at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839132" evidence="3">
        <location>
            <begin position="19"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO00648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="510" mass="54862" checksum="C9469EDA11E250AB" modified="2014-11-26" version="1">MSYPSLLLPFLCLSEISASCCPNPPPCPPPHCWLPHVYRQLYGIRRLVRRPPGSPTSHTFQSIGLMVSEASAPPPLLSESAENHCAADIYALHHRLSRCVKQVEMLMSSSAGSCAASHYQGNRASTSCIRRLGELLREARRLEQRVAEAAFNMTGNAQETSETVDDSMDAPLRAYYRQQLQARFTHLQHDASAAQRLLTQYLSQAPTLAHFPVSCVGTAPRTLERGLTAVTDASFDSAGRIYSDVVPPQAAYIPPAAVHFIEGASPAATGAQDVSPGLGSVAQPKENPDDKERGPSAAASFAVHPLGTPAAAGAATTPEDCIMKDIQQAIHQMKDGALQMSALMEQEKSQMKSAADLLSVGVAKGQANMHELDRVSYVAEGTRVPWMLKCVPGMAILWCTVLQPMWAFLKQTLMMASIIAVTGGVLLLISVVPRPTVYRVQQSHIHDSRASTLQSTATPPFHELPVSLPALYGKGEPVASELPVLAETVEEVSTLPPHTESPSAELSEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RX15</accession>
    <name>A0A088RX15_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_281660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700506.1">
        <property type="nucleotide sequence ID" value="XM_010702204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RX15"/>
    <dbReference type="GeneID" id="22576611"/>
    <dbReference type="KEGG" id="lpan:LPMP_281660"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280022900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_281660"/>
    <dbReference type="eggNOG" id="ENOG502R3JC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271145at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="26724" checksum="E97C0532C92A418F" modified="2014-11-26" version="1">MDSVFGRPQTKVKLDDVAYDKSAPHYSGTVFGLPADNVIFYSKVAAGTFATLVVVYIFFKGYVLLSRFSLQTVARLGFMSGFACCLISYTVALSLIRRYRINADTVYNQSIALVMRNEKVVQHLGTHPRTGDFRTYNATGGFKLPLMRRIRSGSYELSDLLGLKQRRLQMLLTLKNPSSGNEGLVSCDVRKESTGFLSSTNVYKSLSITLYSENKKAEPETIILIGKPEDVVYRSLILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXJ1</accession>
    <name>A0A088RXJ1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">cAMP-dependent protein kinase regulator, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_310470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701436.1">
        <property type="nucleotide sequence ID" value="XM_010703134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXJ1"/>
    <dbReference type="GeneID" id="22577473"/>
    <dbReference type="KEGG" id="lpan:LPMP_310470"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310009700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_310470"/>
    <dbReference type="eggNOG" id="ENOG502SK1Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="260642at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034236">
        <property type="term" value="F:protein kinase A catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF152">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="39"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="174"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="473"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="704" mass="78477" checksum="D7CF0010729DFB8C" modified="2014-11-26" version="1">MWWWRSPPYNASDEHDSEGASSDEWVLLRQVLCTHPLFAICRHDAWILHEIMDAFERHETQPGEVIVSPGDTCAFHVVVMGKALADVDDYGAMTVQEKGQRQEWTARDYFGSEGLLYILHPGYEGAAVRAEGTPDASLPTVTWRLSRVLYQQLMRTFHDPAHLQIIKYLSQSPLLQHLSRAHIRLLCEKAEIVTREISARVLQVGVVPTDLFLLISGTVTLEHEPRHCGGNPDVAHLPTAVFVAGDCVGDAELLFHRVAAEKESTDASKRLTVMPSCYTYTVQQPAQLICIPIEVLLAVLSWDDLQHMRDRSRNVREMELHQVQVQDDLRNLKAQCFLSNLSDTDSNSSMHAPVLQGEPGGAASPLSGELSHDSSQDVYAKGPDATVFFLEQIFPRQTYRRADGRERGLSIASFAPHQRYPAGTVLFRVEYAADHHSVVRAGGGVSPHREENGEGSTADSSTAATPPEVPGRLYAIVSGEITVVNSDTGEPVYRVFRGNTLGEETLLPPLRCRSATTPLRTHAVVSSSDGCEVFELSRRAFKEFLQRPYCDALRDFCDWFSVSPFKGRLPETCWRFLFNCTTEREVVGSDLIGLRGASCKYVSLIFNGQIGAYVRSSVSDSGEKQENEEETSVASFLAGDIIGGWEVMEGRPFPVAYVCECRARILCVPAESFPSLFRPAMLYLQFLWSQERYQRVMDVSSVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXP5</accession>
    <name>A0A088RXP5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_310930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701481.1">
        <property type="nucleotide sequence ID" value="XM_010703179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXP5"/>
    <dbReference type="GeneID" id="22577519"/>
    <dbReference type="KEGG" id="lpan:LPMP_310930"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310015900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_310930"/>
    <dbReference type="eggNOG" id="ENOG502QSXB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272923at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="753" mass="80980" checksum="518C368F5A443AF7" modified="2014-11-26" version="1">MDTRGLRHLKSYLGKAGEKLARAKRATDVVPVLATRQVGTAAARAKSVDFTTVPETVLGPLSHSVMVYLEGRLTSGATYKLSRTQMAVVAALAAPGSLPTRGGAEGSKSGETTLAVTRAKVADMAAVVDTLAVSALELAARRADEGKAVKRTAAEGAFLFVLVDTSSEAAEVAEQLEERYGLTVLLLSGANTCRYPMFPSIANAAGEAGASKPRSAASATLAVKRRRTQSNSRRADEVAPKDETTVSTPVLTGAVVVVVATSAAFLTVDRRSAIWKFIGSCALLLRRAPTHTGSLLHTLKGSKAASSSSTGTMAELLNTHRWDCLGHVPAIAVLAAEQKWLAEPEVDLLTRLRVERDLSSGVGGASTSTASSISSAVAALRSPVTVHYAVAQGAHRFQFLFGLLKGLVPQRGIVVHVATRECVTFLYDALYSLLGELPSYVQLLSDYGGAGTYTNMHTRADRQRLCVTFDSTVEWGRNGKTAAVLLSCHGLVPRRGTVFLQYDLIPDVLNYSQFIADVLSPGAVAADAGNDKGGTTPFTAAEVAVRRETTARQRKRSTSPIPVSMTARKVRTGATNADAEEASLEGKATGPAEVNYTHILLLLRPNEVAGALHHLRQDGSRRYRLEFRELGPQTSGRYHLVGEKLKSMNKKLFALQNAAYYAYKTTMRAYSTIGPRDVYDETKVNLKKVAEEFGFTELPLLDLRLKDTAFRPKEDYYRAARQKQDADRRAYKAFAQANIIGEAPEEHIADNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZD1</accession>
    <name>A0A088RZD1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_330710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702164.1">
        <property type="nucleotide sequence ID" value="XM_010703862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZD1"/>
    <dbReference type="GeneID" id="22578224"/>
    <dbReference type="KEGG" id="lpan:LPMP_330710"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330011700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_330710"/>
    <dbReference type="eggNOG" id="ENOG502RXYK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="274710at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO01364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="152" mass="18873" checksum="D39FD5968C40755D" modified="2014-11-26" version="1">MLRVTHFIRKNPVVFKQGQGMFSHQLKRILNKKSLHKYNWDPLPMYDPRKLVHANRYIDHDTYEEKYDPHWERNAHLVPDQQLYHIPVPKEYRDAYWWRDLQARRIQCPIEWVHFRMHTKDKLKYDFQDLAVRKKFEYSYEDVVANAKDMRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZG7</accession>
    <name>A0A088RZG7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinteoplast poly(A) polymerase complex 1 subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_332620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702353.1">
        <property type="nucleotide sequence ID" value="XM_010704051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZG7"/>
    <dbReference type="GeneID" id="22578415"/>
    <dbReference type="KEGG" id="lpan:LPMP_332620"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330034100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_332620"/>
    <dbReference type="eggNOG" id="ENOG502QW1G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271563at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="678" mass="75429" checksum="BE5443F54DBF16B4" modified="2014-11-26" version="1">MITNPGPLRVTYSPDYLDWLYRAYRAKLKYADERKKAEEVFNGLLLTSQTDVQGSAAAATLPGAPPPGQTLRPRHSVRRQAGEARRAAAQAKLDALAQQQGMLDLFERQPQFPAIHIDKAARCHVVELFKEMVLDRAWKPEEVWDKALLYRAILAERQASYPASYRYILDTVEAVSLAPRESGSNATHTSSSSVGARSLTESSRVTVGESTLAIPREDDYVYFVYLVRRYYIDNAVEGHVVLRCHRHPNASELLFSHPPPKDEQEVLRNLYSPRTARATQSKAVSAETEDQAAAMSKQKLSTAATIARPRPPSSYPPIEALWRCAENEALLRVLVFGELNLLVSENPFVRFPNAQAYLTRPSSSTLAPGAAGSSVNGAEGYGGQQLQPRRGGGYRDAGSDGGISLSSVIAEKRGHLLAPLSRNVAMMIDSRANDVRRLQQRYEREDAAAFQKMLRGGVQAEENPSLYSAYSDWSYFNPRAVRAEERDALSRQTVAALKTYDQASRDIYRVGFEEAEANGAVRPVEGVNNAPSYVPTLPHFVALVKKDPCVSFLAHVALPEEYNSASAAATGVSEKHQLEKLVVQLARALYRTALEFHKQSLRRVNRQKVQVAASLLDRFVVERWRVYCVAHPSSEGVRDMARRFSAYVPFEGRILDESGFPTDARVEDYERWMAAPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZW5</accession>
    <name>A0A088RZW5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphatidylinositol-4-phosphate 5-kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_312550</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701640.1">
        <property type="nucleotide sequence ID" value="XM_010703338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZW5"/>
    <dbReference type="GeneID" id="22577681"/>
    <dbReference type="KEGG" id="lpan:LPMP_312550"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310033200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_312550"/>
    <dbReference type="eggNOG" id="KOG0229">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4280">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270720at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23084:SF256">
        <property type="entry name" value="CENTRAL APPARATUS ASSOCIATED PROTEIN C1A-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23084">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Kinesin motor" evidence="4">
        <location>
            <begin position="623"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="310"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="577"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO00840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="970" mass="107961" checksum="76A4F1DC0593E8F3" modified="2014-11-26" version="1">MGNKHGKGQFAFFNGDEYVGSWKENQMNGYGVFLLASKGDRYEGYWRDGIRQGQGSLYYDNGDLYDGEWCSGLQDGLGVFCQSNDDLYCGQWHDGTMDGKGVLREKGILFLVEYVGGYLISKQRQSEALDETEKEWEPAYRHYLAWIEHHQGPVAPTRSRKEEDRLTSELQAAHAENSILRKRFEDLLALHRQTGRSANAGGESHPTFHSAALEEAGAEYWKESMLKLESKLKLLECTLAERVVELRKLGDQLKSRDARVHELELEKVTHKLRLHGAKHRSTNETLPFEAPTLSAQQSPTEMDTIDADEVEELKDQNALLTRMNNELQQKAAFLAAENAKLVLKEEAAEDQYNKLLEEMVEIRATLENERCINMDSQQLKASVTAAAETDSKPGAAQAPSPVSLSLTAERNLEAQELQQRLTQAKQLNIDLRLRIDKLERTTQAKPNDPGSPFPSQEAAGLARENEVLRSLAASLKTELAAMHSASSNAEQKITLAHQRQVELEDALKTITRRKAPNPQLQETLEWKSERIASLELENAELARLLDETRADTEERAAIPAAMKLQPSIEPMSAGGELASVQKEVKKLQRRIKKLTAERNDVAEQLYQSQVRLARRDRALAALQGQLIVVASITNGGGGAAVEGSATRVDAADPTKLVLCDCGEETFHQYDFCFDKDACVEQLFAELCGPLAFVWSGYQFALMTVGELRSGKSGLVKDILPFFTKYLSKAAEEDPKRFFFSFTYRVAIVEISAHGGFDCASGEAVTEVNYDSNGFVQPRNVHFIDCTSGSIPSVVDSLLTKRRQHYNGRSHTWIQLQCVRTNVVRQCQTIGRLTIFDWCGCGSLASQSKDIESARFANASSQALRGVVTALAGKLPVIPYTKSVEVSLLFDLLGGNSVTAVVGRIRSSVEHIEETLRTLHVLTSLFGVRNGPLLPDNQTSDEIRWRGIVAALASDHQAERELQTVENIREC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S010</accession>
    <name>A0A088S010_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">D-alanyl-glycyl endopeptidase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_332990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702389.1">
        <property type="nucleotide sequence ID" value="XM_010704087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S010"/>
    <dbReference type="GeneID" id="22578452"/>
    <dbReference type="KEGG" id="lpan:LPMP_332990"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330037700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_332990"/>
    <dbReference type="eggNOG" id="ENOG502S56V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272188at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051705">
        <property type="entry name" value="Gsp_Synthetase/Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30094">
        <property type="entry name" value="BIFUNCTIONAL GLUTATHIONYLSPERMIDINE SYNTHETASE/AMIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30094:SF14">
        <property type="entry name" value="D-ALANYL-GLYCYL ENDOPEPTIDASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="52481" checksum="3A9C31C9A181EFB8" modified="2014-11-26" version="1">MSTPRQNLPDDMNNDDGGSRSRHRARPNPLAFPRDRAYGTLRDDNDGEGGCNAGVRNSRQSGLLRSSSTHRLPSSDSMPLWSHVSSPIIQIRDHCHQQWLAVLLTIVLLFLTFYFVFCLSAPMRAEWCATPFGSLLGESSGVAAYSNCRNDYGGDRMERFVSVGLQRLSTGFKWKALEYARRYWILKLLLTFPPLPREDYAILTEAANAVNGLRGGRGSSVVPLERYANLFLPSVVLQNSSQDMPAMKLNGEPNNLSASVHLKNRQKALVQPYDIVVYAKNSRTLPSGHVAVVIAVHGPFHSVTAAGKEVHWFIVKNASTLGRQPMAPWSKLPQQLLSQGNGFVNDSVAQPKNATRYDTERYSASSECENASAKGKANMISGCSVLYYKVFIAEQNWDNSYWGTLSYLTGSPPHNNTANEPSSRRRRKTAAGMRNYTRVLLLHEYSNPHGFFLEDTHNNVILGWVRASSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0G6</accession>
    <name>A0A088S0G6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_340450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01671.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702471.1">
        <property type="nucleotide sequence ID" value="XM_010704169.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22578549"/>
    <dbReference type="KEGG" id="lpan:LPMP_340450"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340009800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_340450"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0586">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF92">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO01671.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1714" mass="183677" checksum="ACE58E7F1AE76377" modified="2026-01-28" version="2">MQLVRQAMSWNATSFFTGSFDLEDEVKVLGDYTVGHRLGEGAYGSVYLVKYLPSGDRYALKILQKQDLFSTSGIYPIAYYHSYGGASPREGDGAESCPLGGVPVSMASALANTLEQQIISEAMVMQALEHPHVVKFYKFLNSTTAFYFMMELAEGGKLLDLILFKNYFSEDEARMYFQQLISAIDYCHRNGVAHKDLKAENLLLSNDGRLLVCDFGFSLKVAKENIDDPEKTIVTGDNAALLDSTGNGCVFGTLHYTSPEAVMASSQQRKLTFVRDSMAVPAETSGIPEDQSEGLAHCPLAPTVAASSSSSVSSSSLSHSVSFAQGWRRRAAGLTTSKRWKMHGKFSVKGSGTNLDASHRITPTGEAEAVQRLPAEEGRVRPSPSLRRTGSAQSLAGDTNGARHKGVSPTSGLNRFGEGLSMFVKFLMGSSVNSSGGRQAHDSHARSSHAKSPKAKQRATAVLSSAEATAKLKRSSSTASFPDSREMEGGTSEAHQPLRHLSADASSQERVLMLSSDVSSSVSPTTSPFATSLSSELVDMAAARIAAYPSATATAKPSMPLPSISSPTTSKPAVTSPAPRHPDTEDIVAVSDVNANDLYSPDTAFRRDAVSAQRLALPAPQMTASVLDAPRSRSAFPQFSHHCHQTHDHKHHQRRRQQRSDTSSWVFSASTPNKLQPIIVDPFQQDLWSAGVILFFMLTGRLPFDGRDDEETLHLIQVTEFAFDEEEVKRISPAARRLVMQMLAQEPTDRPTIEQIIVNQWFRRDLQLEKDFPHRKDLIEALRGATPDSVQQHPLPQKSAKGAGLAADGYGGQSGAGCGSDGSACASTSRDVPNSFGSNVANARAESPLFHSSHRDMRIPATQVPSCNISFCAGSSARPGSAPGLGPSSGPQRDTPTFATCDFLDFSTHHPVTPEEERVLETAFRKVDSDGYGCITRDQVRDMLTTLHGDFVPTEDVDELVRLFTGDASAASITFEQFRDAWVSKDLAHIPFTHSSEFQLVNIIGTEMDAVEQGVIRELRTAFNSLDENHRGVIQLHQVQRVFEKHHIPVHKEECLSFIKYFHETELTRCPKRAFFYSQRWGATPTTMSLSPPSGVSLPLGFAKARSLPFTTGITWGRSSTTTPQGATSSTLPSTNDASDPVTGTTIPTTRGTVCSGSQTSLPPPDSPMSPSSIAVSFDSFVRGIVKSDILLKHPLGRKLAAATNLAALFQSRNVTECIQHGFLVTGLQGVILEKLTSVPERLLLLYSGEIISNTENIYSFRYLGSSVLTTGATMRTTTSPLMSLSVATTASSTEPATPSVSRCCPVSSDASNGAAGSTVATSSPGSLPHNPVVSSSDRSTVCALSACTQPPLASLHNLSRANSLGSATDFLSPEQVSCNTLTGRSVLVLQSQQSTTVPVLRSSNRASATVNAAAHPATTLSAVARGMNRSRSLALPCRSSLLQPLPVSHRTGCNGDDTHSTVSCSHNSSPIVNAAIDDSHSNSSRGALSFGLGEELEGLTSTPAAGGRRRAKDDVKPPNPASRGPKNNSLITTAGKAGVCQRRQHDTTDPAALGEAEKRKERSKVSAARGPAKGARPLRHSSARTGASLSSRFAAAARLTPPPWLTSTQSTGVEVSSSLPYNANVSSSAKVFPQTQVAPSLLAAHSVAAMNDVCDMDVILSPASMGYTMVQFRLIRGKTSDFHEAVTFISNVLEREREQAMQDTMTCGESELM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0U2</accession>
    <name>A0A088S0U2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_344010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702823.1">
        <property type="nucleotide sequence ID" value="XM_010704521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0U2"/>
    <dbReference type="GeneID" id="22578906"/>
    <dbReference type="KEGG" id="lpan:LPMP_344010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340047400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_344010"/>
    <dbReference type="eggNOG" id="ENOG502SI8H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267581at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="417"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="583" mass="60286" checksum="62BFEB191AAE2AED" modified="2014-11-26" version="1">MNSSATPVLKLQPRSINTTHGSVPGAKSVSSSSSKVRTRSIRVTSAPCSEVRPRGATMTSVLSVTRRTIRKVKPISQDQPHVALVEASEPQTRSSAPVSLLSIFTKKSCIGDSVMAPPSAGAASKLSVHCVKPSSGAAVATPSVVLPNRSASRADSTCGSLRGRSNRGFADLRQLPPTVPRVGQLSSNVPLMRSATVMTASIRRTSSVTTIIPTASAPGSQLCSRTPSVHEVAVPLSPRRAPLPVRPYTSAAASRVNSVNSRLAEGIARPMRQPSQCPHISSVRPVTKRSNSSASTTGPTRTTSPIAPLSNRAAMTADDGMRAPSAALGVPPRSMGLRPLVGTNHVSTPKSGGVTDASRLRILHPSFQSTLRADRGTRSARGGASSGRNSNAANCTSARGASHQAPVRQHQHQQPLSARCAASASPSRKVTRKLGSDSASVAVAPAPPAPFQKTHTGYTPLVSFAGFVQGPGVSAVPRGPVSPIRRTSTACPSAAQHYPAASAENPARASRGLASPNTDAAFANPWIRPSMLSTPTNRGGGRDASEAPTLPYEGSTGQRGSLSLSPRTDFDAFSVSGRLSYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1F4</accession>
    <name>A0A088S1F4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_330970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702190.1">
        <property type="nucleotide sequence ID" value="XM_010703888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1F4"/>
    <dbReference type="GeneID" id="22578250"/>
    <dbReference type="KEGG" id="lpan:LPMP_330970"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330014300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_330970"/>
    <dbReference type="eggNOG" id="ENOG502S6T5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264750at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="520"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="861"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="534"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="882" mass="96479" checksum="B443DB5849042219" modified="2014-11-26" version="1">MNAQATTSLSAMATLRSNKAAQSTSVAGVPGSRQPHSLRLAAPLSSSAAAAALALTSKQRFVRKDTLHSIAFLLRHVAVQIEAAALQDVMADPVASEYIMASVDRADELNSTTASASAPAAPCFPSDADRPAHRSMSSSESGADWVADAWVPSPRHDTVTQGMDSPLSRPTTVSNNLVRVPSMPTSSSIGSRSRHGRPSLPLSELHRQSRSAVSRTPIEQAIHAAIAAARSQTPPYSFPEKWFGHPAEAVALHSAQSLARDTVLNPSMRRALAATAKGFRPHWQAPEFSSKHALTTSTSFVTVSQSESPGTAVTLPPPPPPTRPVTATHRSPSYNRADQKKVLAVATAQPPLFFDNVLLDPETNRYLFRGCAFREEARVLQAPAVSASLTTASYVGDRESRDHANKPSRGSLSPSLLLVREYIPISAECSVVGEELQPLDASRDDTDAVVVQCFSLLPSQLAHIRPNQYQLLPESTIVRCLLVALPGCVTLATPLDAFLHNVRHSLLMVAGYSVDRLLGNPHGATKETRQPGGTRTSSPTATMTSSTSTAHESILYSSSSLEVTCGGGASIISASGAATKASLDTTGRDRDAARIAVVQEKLAQVVLPDILDEAMHAICSTLVVYCTQREQWRHMRVAVDAVLVLQRFFRGCLAVKERAVRRMMRLWRRLEVDARLKLQEHRPLPSAVEKIDSVANNILQEHMLTSTSYKRAFIEEQWAQRRRSFAAWRQDKEWDSVFASAGWRKQSSVDDNATDSAAEKRLRSARLSAAEQLRLESEFNKRRGWSSTVMLQCVVPPSSPTAAETYAEREQVAIRRLLSWYIDPRELLYLSHQRLLETLKGSVFRMEEVQLELKRATNRVMQEDSTTPLTDSVSCNSVHQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1H4</accession>
    <name>A0A088S1H4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_331180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702210.1">
        <property type="nucleotide sequence ID" value="XM_010703908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1H4"/>
    <dbReference type="GeneID" id="22578271"/>
    <dbReference type="KEGG" id="lpan:LPMP_331180"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330016900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_331180"/>
    <dbReference type="eggNOG" id="ENOG502RZ8S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271875at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="536"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="591"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="631"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="668" mass="70768" checksum="FF50036ADEFEBA09" modified="2014-11-26" version="1">MRHCRSWRAAPLLSGLLVVVLHFFTLYSAAARTRELQLYCLPAEAEPHGVISCVLQGQDGYQVATANFDHSDFIALTRTSNAAATITKSALVRGSDITTAVFTMSVSTGTDVLIWVYLQDTSAIGGYSDTGEVRRSGTTVSVPPWPTLPLGPITCSAQAAGLALRCSTVGRVALYSENNTLSTVHSAGVLFSETSVLGSFTFTSGAKELVLRFTESPKTPAPVSMLMLKVHLRSQDANVSGGGVQTVQIPLLYPSEVPLSKTTGLQCTADMGRITCAITESDTQGPSAVNATHFRVRVEQSVETVAGAADALSSLTTNDSDAAARYWVDVTNTVSLSVIRSALHPYAGIVSWVLKSNDAIYEARFRVLSSMNGQEVHTATGQSAATAGNAADVAGSPYAFRTVMLPNAQSVTLRGCRKSVIAAGNTTLCFIDLASGVSGDTAFYLITTSQRQSSVSNVTYVTYDAACMCRSLWFTYHAPIDLISRVDDYIKVSVYTDAEHSASGMVIANNVPLRLDVLPVEADSGHDTSAAPTDAILMSVGLLFYGGILVVGCGFIVRRSRKSARIRRERARKVRATMQEMDRHQCVPTPSAGNLANNASALTRTPEVKSTGIRAGPDASGYDTPNLLGVGAREAGSEGSSSRLSPLEPAAVVSNVAVPQDRLHSESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1L8</accession>
    <name>A0A088S1L8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_040510</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TTC21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="AIN95376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703698.1">
        <property type="nucleotide sequence ID" value="XM_010705396.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22572010"/>
    <dbReference type="KEGG" id="lpan:LPMP_040510"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040011400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_040510"/>
    <dbReference type="eggNOG" id="ENOG502QQAB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10259630at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:002011">
        <property type="entry name" value="Predicted tetratricopeptide repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056832">
        <property type="entry name" value="ARM_TT21_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056836">
        <property type="entry name" value="ARM_TT21_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056835">
        <property type="entry name" value="ARM_TT21_5th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056834">
        <property type="entry name" value="ARM_TT21_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056833">
        <property type="entry name" value="ARM_TT21_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040364">
        <property type="entry name" value="TTC21A/TTC21B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14699">
        <property type="entry name" value="STI2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14699:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 21 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25058">
        <property type="entry name" value="ARM_TT21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25060">
        <property type="entry name" value="ARM_TT21_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25068">
        <property type="entry name" value="ARM_TT21_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25064">
        <property type="entry name" value="ARM_TT21_5th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25063">
        <property type="entry name" value="ARM_TT21_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25062">
        <property type="entry name" value="ARM_TT21_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Tetratricopeptide repeat protein 21A/21B N-terminal ARM repeat" evidence="7">
        <location>
            <begin position="14"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Tetratricopeptide repeat protein 21A/21B second ARM" evidence="6">
        <location>
            <begin position="300"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="753"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="787"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="domain" description="Tetratricopeptide repeat protein 21A/21B fourth ARM" evidence="10">
        <location>
            <begin position="789"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="1050"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="domain" description="Tetratricopeptide repeat protein 21A/21B fifth ARM repeats" evidence="9">
        <location>
            <begin position="1051"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="domain" description="Tetratricopeptide repeat protein 21A/21B C-terminal ARM" evidence="8">
        <location>
            <begin position="1433"/>
            <end position="1554"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="1475"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1187"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1280"/>
            <end position="1324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN95376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1560" mass="171418" checksum="C32322488F93715D" modified="2014-11-26" version="1">MTATILRTNYALLLFYVRENYWRHAEEVCLSTIQSTDDHMFRVWHALTLERQGMANDAIHEYKAVESRRATAVPALMGMHLIYKQSRDQEGVAQTESKLDTFEVANNLGGWVQAAALCWAAGDTNAARDILLKLTDNEITMAHRDEYTNYATIRGWVDLLSGRGALLEKAGTLFSSVLEMEEAHYSFYQADTKPGGGGSGTTKWTDMNAALGYVAFLERKTQFSKAQSLLDRLIVLYPSCSIPPLVSKARLLMHAEDWEQAIEVTRRILTRDKDNVEALTLEALYALAKDTRYDAAMVRLRRLLDAVRAKEPRNATLLHQLALVFSRLAGGRWDLLNITTQFSELACALQSRSGDVLCGLGYQQLYRHDYKTAMATFRKAAMLTDTVAPLLGTVACLLREGDLEEAATQLQFCNQLQPVAQRNAELSMLNAELRWRRRGMEEETAVLRYLDQAAEAIKHDVKAHAGSGMEVYVHLNSPVALAVAHAYLMHCRNEPPDPMFKHTDVIGEKCGRHLEFLVQHLPACMEAQLMLAKVWFVTGEVRKAQNLLKSTLLVQEQPLPEAFLLSSQICQYMGDVKLASRALEQALTLDFSLQEQPLYNLLLGTVQGTTGKSAEALASLQRAYDTVKSAVTTSSSGKPMQSLSVPELVTLYLQLAQAQLRVRDVDAARTTLMEAAFKFRDSTQVGRVAIAQAMLAARTDVDKSIELLRQVPSKSEFYIAAHSQLGKLFLTQKHNVAMYIRCFQEMAEAAPSAPSYVALGEAYATVQEPEQAIAAYEKAKALSPSSNELSVRVGRALVAAHDYAKAIQYYQDALMSDPHLSTVRTDLAMLQWRLGRIDAARETIMLSPVYDLSSTSGTEAGLAPSVVAGSEETAGTAIERINLYLLLYKVLRDQPWTVPLSAQGTADTGGDGDAALTALLRARSLQQRLLEQQLRAETANVSAEQRVVMSGICTELGVRCMYSTPAPPPASIIMTDKKIEAAAALAIQSAVAVRLTNAREYLREAITYDESNERAHLESAQLCYRTKDTDGCERHCKTVLHMAGGSTSNAEAVILLANLYSQQGRPEDAREMFEGLLKKTPQHYEALVYYLVLLYHAGQLTEAKDALDRAAAAVPAGQRVDPGLSYARGLYEHFCNSNAEALRHFNLARLPADNPWCTRALVRMIRIYLVPTTQDLWVRSASPAAAAASSPTQQQQHRKSLPSNKSSSAALPMGAVTGGTDLHDSIRYAEQLLLLLPVYSEERRILQAYCAMATRRPEELDTALHLFLECIVAAETGGVSGTKARSGATAGEERHSSGNHNKSAVAGAAKPSRHVGNSDSEDDDEDLQLLASMHEAAAQRVSGSGNSTATLAFALQCTVVHPAAFLGLAITLFVSGQETAARNVLARLLESKNVVTRVQAVMPADQNKGDASSNDTAAPSAPVIISPPIAIINCSEDDTVERAMLLQAYMDTQVSQLEDARFVLRQVLTANQSCGAGWNALGMIYERQKKHKEASRCYQKAWELVQESDPAVGYKLGFNYLRGGEPVKAIDVCKRVLAHHATYPRIEADVMDVAYSMLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S248</accession>
    <name>A0A088S248_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Coatomer subunit beta'</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LPMP_333320</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasmic vesicle</location>
            <location evidence="1 14">COPI-coated vesicle membrane</location>
            <topology evidence="1 14">Peripheral membrane protein</topology>
            <orientation evidence="1 14">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Golgi apparatus membrane</location>
            <topology evidence="14">Peripheral membrane protein</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="14">The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the WD repeat COPB2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702420.1">
        <property type="nucleotide sequence ID" value="XM_010704118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S248"/>
    <dbReference type="GeneID" id="22578485"/>
    <dbReference type="KEGG" id="lpan:LPMP_333320"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330041600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_333320"/>
    <dbReference type="eggNOG" id="KOG0276">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261470at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22947">
        <property type="entry name" value="Coatomer_WDAD_beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000016">
        <property type="entry name" value="Coatomer alpha subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000001">
        <property type="entry name" value="Coatomer subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016453">
        <property type="entry name" value="COPB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF2">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005567">
        <property type="entry name" value="Coatomer_beta'_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 14" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <keyword evidence="5 15" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="96"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="139"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="182"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="16">
        <location>
            <begin position="322"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="17">
        <location>
            <begin position="595"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AIO01620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="904" mass="100277" checksum="DBF676AF56BFD365" modified="2014-11-26" version="1">MSAGTMATVEFTAPSQRVKMVDMHPKEPIFIAALYSGGINLYNYQTQALVRSFDTGTGLPVRCVRFIPRLQSFVCGCDDMNVRVFNYHTMERTKIFQAHDDYIRCVAVHDQLPLVLTCADDMTIRQWDWSKGWTLQITYEGHQHFCMAIAFNPKDSSAFASASMDCTIKVWRINTPIPNYQLEGHEDGVNCVEFYPRGDKPYLLSGSDDRTVRLWDYQTKACLQVFSFHDENVASVLFHPDLPVIYSISESDHIAAFSTETFRLLYSCSHSDMGRGWSLTAKRYTNMLIAGFDNGVRAYKVGVDKPVFSMDANGRVLVVTGNEIMRMDIKAVGSETPDGEVLSVATKDMGAVEATARSIFHAGNGQFICVLGDDNYTIISALSLRPKSYGQCISFVWGPESGAYAVLESSTTLKIFKSFKGRAVLSLPAVADKLFGGPLLAVRTNNSIMFYDWGTLALIRQIDETPMTLEWNATGGLVALVTSSGVFLLKFNGDAVAQYLEQNATTSDDGLDFSFDLVEELDEKARDVAWVGDCLVYINQVHRLNYYIGGEVNNIAVLNRNQYLLGYLPKENRFFCIDKEKNITSYRFEVNVMEYMAAIVREDFDAANALLPTIDVSLRDKLSRFVESRGLLEIALEIATDDEHRFDLAVQLKQLSLACEIASKANVASHWKQVGDIALEQGYFDMAIESLEKCNDWSGLLLIYKSLNDMQAISRLGDCCLQSEQANLAFTCYHLTQRHAECVELLQKTGKMGDAAFYARTYCPNLIEDAVAKWRASVASIPRVSQALANPAAYPNLFPSLRYADLSSRKEPKADVPLSMSEPAKVVADIDSARDHTPLRGQLAAEILPQPMHTPMEASQSSVVSPPPPSFQAIGVATTDAAPVHDTVGSVSNEIQELVDESGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2H1</accession>
    <name>A0A088S2H1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_341190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702545.1">
        <property type="nucleotide sequence ID" value="XM_010704243.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22578624"/>
    <dbReference type="KEGG" id="lpan:LPMP_341190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340017900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_341190"/>
    <dbReference type="eggNOG" id="ENOG502S6JF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273748at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="923"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1098"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1358"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1637"/>
            <end position="1702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1108"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1127"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1156"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1373"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1390"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1401"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1426"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1682"/>
            <end position="1692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1693"/>
            <end position="1702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1702" mass="185775" checksum="5491D86906713292" modified="2014-11-26" version="1">MTTTTATGVNALHDVLPPLPPQVGVTGSALALDRKVLQALFASLRMSIPQDVQRRLLCNSAEELQFIIARQPRLSAFHHRRRESLRHPALAMATKNYYRECRRRRLELQLQPTATMEGQSLSQATGSPVGQVRSGVRSAQRESALVDLLFSEYAQQSAGYAKDQDRQGDHYGTNTSNGTSGSGGFAASRTSLSLSTYTASAPSRMLGRVISEADYEASLQLPTTPRGDHAVDFSSTLASNRSGILLHRPLSLRYPKSSNEESASAFSDGLNTASFTRFGLSATGIENAESGGGARVRGMGMGVSTASTADGARFFARRIGNNNNAAVHRGGSGGCGGGDRFAPSWTGEMRVLLQRRMEEELETGTGNDPYLFISARPVEHLLCCYGGFSRDPVAMALGAASLVECDNNNTADTDPFFNAIVEEDLRWDQLAECQRQLLRAACGPCRAAATAVASDPLVNDVIRRFWDRLTVSTAAQHAHMTQEARKSRAAADAAIAAAASARSGRRNGEADEDDLNEISESDDRGREDAVAGGTGSGGGDVSRRGASAVSISRTNRKASKPSRTPKTGLKLSKKKKRKGGSAVFFGGSSGAGGGSPQHTSVAYYMTPLQYVYLHTRIAHVLLPDCDAAEVELLPYIQEDLLVDAAYDEGDAAQTFYFGEAPRLVGDSRRPHRESTTAVGARGTSWTSCMDDKLHLGNYDSAGGDSMFAGGGKAQRDALLLQRRFLSVRRNGYALSRSTRVDATGVGGMYEMGLGDDRMSIGVRSSVAVTIDNSTVMRLASEFDEVIGRSPATASLSLVPMSFTVAQLPSLTYPQFWCSMMELADNWTCCAGNPVETAIFMWELYAEVFAHNWGEEDKLLATAVESKAAKSALSAAEKAELAKEVADTMESFQALLTEMREQRSQPSLRRDSLNSITSMTNVTHTAAGRSGSCRQQFKTKRGKGTHSPSMGSADTDDDESLLLASYVDLSPSELKSLAEAKDEGDHKWVYVERIGEDGMMHRYRRRMYHGGRRSSSCNASETGSHRGSYIVEEELDEDGAVVSQRKLRWRMTFSSDSWQSGSNSSLYTADEGASEFRRRKYYEDRPKKLRRLELWRHVSASRGGRDSRSSSMTSWSTIDDGNSDDRRNGHRRRRHTRHTGLRRDHPRHSREDDQYRGRKSGRRVGRRLPFNEGVPDSGGRGSRVHRSGKSRLTQKELEYLLERKEWLCSMLEEKGIQLPPHMLDDPAEQVLLYEFLRLAEGREGGGDQGSCLSGSEDYYHLEDGEGGDAGNLSRLSALLAQVQGLTLDDLANSTLMRRLLEESEAEGAPRHHITPQQVQAILMALIKMQRPGDARADAGRTEQKSVRERRLELLRMLKKQRALQQQGHKESAATGLSDNSLTKATFGLTEVPPPFPRPPSSKGPQGSTSFTKLPKFAASPHPHDAQSIPSFATSSPQRDFSCESLGLPERRTPTSRESSAPSTARLFANSMAWKILPTTLAERKELERLFRELEAYWADRVSQGGRFRVDIIDYTPEQLEEFFAHLHLGPRQRALLRGRAPLAGATSLVGGTMHQDGSHLTYSDGVAVAAQQQHGHGACGQSAPSRMPLPPPLAPAPVKLFTLTTENTLEGALRCSYQSYLRDKAFSEALHGNVKLDTARGAQASTATQSPRPPSLPRLRLRESREKASGQQADGRPTTFVAPSPPPPPPPKSSVPSSSLPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2H4</accession>
    <name>A0A088S2H4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_352890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703226.1">
        <property type="nucleotide sequence ID" value="XM_010704924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2H4"/>
    <dbReference type="GeneID" id="22579318"/>
    <dbReference type="KEGG" id="lpan:LPMP_352890"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350036300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_352890"/>
    <dbReference type="eggNOG" id="ENOG502QVT8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271885at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO02426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="598" mass="67069" checksum="7E6C8B3C7E146D75" modified="2014-11-26" version="1">MFFIYPTPQYPRRTLEFVFKSLYTLANAVHLASLVIFMSDFFIRLSNSMPSYYRNRNLVISDSILLVMENCTYNGSILLGNVRGTVEVTSGNIGYGLMTMAQYVTGIFVLEFLLLVNNLVAALNYTKGNRHLRIFGVHVPLYHITVMLTQVYSIAIVVLVWAFDGNRQLFQRALQYCAEQMRETNYEQLLNSEFDNFTIFSAIVYLPFAATCVSELIYISAVIVLCYFSSDEGIILLSEADAPWESRGLLCNTSKPLLKLHTAQRNAIIEDARNAIKKGQKVRIVRSYQLTTEEAFEALVQAMREQVARALKEKRFEQLKRTFGDNESQLDKMGFAWRENLMAARPDEMSGGVEGELPSGLEAGPGDQFFDVPFEDYFTENEANGIDRGRFGDNDGAVGRSEVIYSDEPLSIHEGGFGDDGGTYGYWNNGFTLDPADDSGATQDAWSPQEGEYTMEGAGEIYDPSQSQQYSQGASHTHHRRRHRRRRRDDAKDDIDDRAEPSPRMPLQGQQRVSGKSDLHGGDTYVSPSNYYNANDGMAYGGGGDYALGTGQGGRLESTNSNYPLSTRESGQRRQNRGRQAGLEQEDDVADELSDEFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2J1</accession>
    <name>A0A088S2J1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutamine--fructose-6-phosphate transaminase (isomerizing)</fullName>
            <ecNumber evidence="3">2.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_060920</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="3"/>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703973.1">
        <property type="nucleotide sequence ID" value="XM_010705671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2J1"/>
    <dbReference type="GeneID" id="22572298"/>
    <dbReference type="KEGG" id="lpan:LPMP_060920"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060015400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_060920"/>
    <dbReference type="eggNOG" id="KOG1268">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="15235at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006047">
        <property type="term" value="P:UDP-N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00714">
        <property type="entry name" value="GFAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000001">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000052">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GFAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047084">
        <property type="entry name" value="GFAT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001484">
        <property type="entry name" value="PRK00331.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937">
        <property type="entry name" value="GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="GLUTAMINE--FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 10" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="8">
        <location>
            <begin position="2"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="9">
        <location>
            <begin position="347"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="9">
        <location>
            <begin position="519"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN95651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="670" mass="73515" checksum="4A5A1676179348B0" modified="2014-11-26" version="1">MCGIWGYVNHNVQRTVEQILDVLIRGIQKVEYRGYDSAGLAIDAGIGSENDGGAAASAPTPRPCVVRSVGNVSQLREKVFSRAVAATLPPMDAKTSHHIGIAHTRWATHGDVCERNCHPQQSNNGEFTIVHNGIVANYATLKELLKAEGYAFFSDTDTEVISILSEYLYTRKGIHNLVDLTLELSRLVEGSYALLIKSIYFPGQIAASRKGSPLMVGIRQTDDYGCVMKVNTHDLLDLWKSHELFFASDWSSFVEYTNNIVHLEDDDVAHYCDGTLRFYKAEGLSSSTVKREVQYLDAKPESLSKGNYPHFMLKEIYEQTESVISSIHGRIDFSSGTVRLSGFTPQSIRAILTSRRILFIACGTSLNSCLAVRLLFEELVPLPISVENATDFLDRKPPIQRDDVCFFVSQSGETADTLLALRLCCEAGAVCVGITNAVDSSISRLTHYCIPLNAGVEVSVASTKAYTSQVVVLTLVALLLSDDSVRLQERRQEVMRGLAELPVKISEALKITHDSVKALAARLKESSSILVLGRGYDLATAMEAALKVKEVSYVHTEGINSGELKHGPLALIDETVPVLAMCTNNRHFHLSKTAVQQVSARKGAVVVFATEADAELKAAAREIILIPNTVDCLQCVVNIIPFQLLAYYMALLRGNNVDYPRNLAKSVTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2L3</accession>
    <name>A0A088S2L3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_353570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703294.1">
        <property type="nucleotide sequence ID" value="XM_010704992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2L3"/>
    <dbReference type="GeneID" id="22579386"/>
    <dbReference type="KEGG" id="lpan:LPMP_353570"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350043600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_353570"/>
    <dbReference type="eggNOG" id="ENOG502RY1R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276065at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003352">
        <property type="term" value="P:regulation of cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021298">
        <property type="entry name" value="CFAP298"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13238:SF7">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13238">
        <property type="entry name" value="PROTEIN C21ORF59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11069">
        <property type="entry name" value="CFAP298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="338" mass="37974" checksum="07F92B912324E4B0" modified="2014-11-26" version="1">MVFIVVKGTSYPDEFTVERALTDVLSSSEQSSRGTADLSSPPSVYMSSSRDTIVPAIAHILNKRHHVRLMLMSAQELVTLWPQQQRRFDDTANTEARENHELDEVVGRYQALIDELNRRLKDTKAPVSANEFDNAELELRTFATALYPSLCTHANGSEAAVEQLYAKYEDPDLDEDTRLVVYHCRVLLDSEWKANERVKEDEAALWFCGKPMEATLAKYCGRNEKSKVIVKVAPRKGPAPSCEPRMRYEDQRALYHAMCQRRETYKQLDDSELRDRVVRQSRGAEHLLLGATAAASSLSTGTPIPPSSASGTSNAAALRTDGLRPIFSRKEERELPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2N1</accession>
    <name>A0A088S2N1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_070250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009376">
        <property type="protein sequence ID" value="AIN95711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704033.1">
        <property type="nucleotide sequence ID" value="XM_010705731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2N1"/>
    <dbReference type="GeneID" id="22572360"/>
    <dbReference type="KEGG" id="lpan:LPMP_070250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_070007400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_070250"/>
    <dbReference type="eggNOG" id="ENOG502RXV5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272657at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="617" mass="66203" checksum="99BD5DAFC4925212" modified="2014-11-26" version="1">MRYFRALRARQDIVEFLVRRGRLADIQMLNFFSIHLDREISAATAAAAVPRSTPEAGSAGSGEESVHPAKQDEKAAVAAATSDTKSTEAAAAAEAGAQRVQKLEARKKAWKAFRDRSDVVRQLATKEGPMAWLKEVYSGDDKWSSYFTAVRAVVTHAGGGAPTKLKASGMATAISSGYAQIAKMAAGSEGGQCRQHGSTYATPAAHALPKSIRVVLRLEGGKGVAPKYVMGSVPLNQPGAVEQRIVNGVLQVRLDNADAVQCESLSVEQVTSYQHVLVTMAYSAILRKMAEVGALHATNTVRYDGLLIRNPAVQMRLAQLACFRYGIDCLTDYVVGDPEVTDGDDAAEPFSSFSEPLQIPLMESIMLRIYAEHALMDGIDGMWEMVRDTSLVVAVPHRSNPTKIIDYPYIAELFNSPKYLLTSSNGTTEEQSMAFLYPLLAQCSSSGSRAGGSRTGIGGMLEGLIGLTAGHSYGSVRLAAPHVNLTGLAKTLELDVAKLLNVIATEKGKLDPGFVISVAQYISEILANLAVIYRCTAALNVDEEGRGHREWLLAQAFGGSSAVRRQQILDGYIMERAATSAIRKSNSLDNYSTHPIELMNASPRNAKASSTDKAAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S328</accession>
    <name>A0A088S328_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amastin-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_080670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="AIN95876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704198.1">
        <property type="nucleotide sequence ID" value="XM_010705896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S328"/>
    <dbReference type="GeneID" id="22572529"/>
    <dbReference type="KEGG" id="lpan:LPMP_080670"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000051900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_080670"/>
    <dbReference type="eggNOG" id="ENOG502S5SU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265473at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009944">
        <property type="entry name" value="Amastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297:SF4">
        <property type="entry name" value="AMASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297">
        <property type="entry name" value="AMASTIN-LIKE SURFACE PROTEIN-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07344">
        <property type="entry name" value="Amastin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="186" mass="20875" checksum="A7250D762CFC9093" modified="2014-11-26" version="1">MVFTVTLLLYAVLQFIAFIFVLVATPLDMFRVKDLGRFGNTPCLTLWGGKENCNTVRSDTSYVELWSFCPDRLARFRLAEVFAVISIFVYGSAVLLGFIVVFCCTCLRWICLALNIGGALTVCVVWVLMVFDYQHADGLCPAINTRFNFGNGFGLFLAANFLDIINIVLLLIPCKPMDPSKENTQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S386</accession>
    <name>A0A088S386_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Adaptin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_355380</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703469.1">
        <property type="nucleotide sequence ID" value="XM_010705167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S386"/>
    <dbReference type="GeneID" id="22579566"/>
    <dbReference type="KEGG" id="lpan:LPMP_355380"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350062600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_355380"/>
    <dbReference type="eggNOG" id="KOG1060">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="302453at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026740">
        <property type="entry name" value="AP3_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037096">
        <property type="entry name" value="AP3_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="7">
        <location>
            <begin position="49"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="277"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="709"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="803"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="736"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO02669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="850" mass="93296" checksum="0866EF62154D0BD3" modified="2014-11-26" version="1">MNGAALIEQATFVTERAWEYASNTTSVFSKARSLVAGDAQFFSVAPRVDDLRRSLSSESLHDKRDGMKRIVAQMCKGSDMRHFFPDVVKNIHVPYIELRKLIYVFIVYYAEDCPNETLLSISAFQKDLLDPSMHVRALALRMLASLRIHAIQPVVLVAVRKCASDMAPLVRKTAALALVQMHTVARQELDRDTVRQLLRTFLSDRSPEVVGAAAMAYMRICPEEWDLVHGVYRRLCRILKDCEEWGQVVLLRLLLRYARRHFVDPRRPFAARAARCSRGSSGMSGKGTDGDDDDDDATSSSHFSIAPPSREYEAQRGDAAAEAQMDPDLLLLLSSTRPLLWSLNSSVVVAAIALLCHCGTQRFQETCVKSAMRLLSTCTEGHIAVLHVIYDLLLLQRDAFLPYLKSFFLFPLDAADVRHVKLRILSHLVTSATSAEVSREFRSYLRQYNDAAVVEAIQGLAQAVQQYPPFAAHTIRLVTPLLSSRTSSPVVVADAVAILRVLVLQGTDPVRISRLACQLTLDIMEERITEPSAVSTILWLTGENISKHPSMAAAAPDCFRVFAKRFGGLTSEVKRQVLTLGCKVWVQLQGNSELSERFKQVYHYVAELARYDDDYMIRDEERLTEATFDRQSDTFTGVRAALLRAKPLPDVNDPYSERAGLEIGTFSNLLGPAVRVLDPLPTWATEATDGTLRRSFEEMNTSAAAVALFERTSGEKESGSNDSSYTDGEESDDSGDAASSSGSYESSYSASSDAENESGKSSSHSDGDVAAPSRAPAMQKVSSGVSTAKASLPKFAVKITMQSVPPSVPSPAPAQATMTATEKTDASPAAVPELPPAPETVAEPQSVVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S395</accession>
    <name>A0A088S395_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mitochondrial chaperone BCS1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_355530</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703484.1">
        <property type="nucleotide sequence ID" value="XM_010705182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S395"/>
    <dbReference type="GeneID" id="22579581"/>
    <dbReference type="KEGG" id="lpan:LPMP_355530"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350064000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_355530"/>
    <dbReference type="eggNOG" id="KOG0743">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BCS1 N-terminal" evidence="6">
        <location>
            <begin position="85"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="308"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="15"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="378"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="383"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO02684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="547" mass="60378" checksum="B2C9036D0D8C2D23" modified="2014-11-26" version="1">MALLYRRPGKEVNFLPAFASPPPDNRSDARHRHGRERRRARQQRGDRFTSRTWDQERHDGEGRKAGASSGPLGNNQVIGLVVAIFLLSALWDFFTAQKSVVWHAIKNSVVTTLEVRSSSQEFAMIVDWMGRQPCGQRIRNLGLKPITVQDEQRMVGGDVPSSLSDDAAASAHADARVMLVPGYGSHLLRFGSTWVYITRAEDSSKQKAAAANRVDRENDKLTLTFFTRRRAVVEQFMAHVQESWRANVRNTVHIYLSEGYGPRWHLLSERIRRPLSTLYLPTETKAVVEEARLFLQLKGTYAALGIPWRRGYLLEGPPGTGKTSFVMALAGELGLPVHILSLRSDHMDDDALLSLTSSLPRRSILLIEDLENVLKTHSGVGRSAGSPKASDAAATAAAAETTSTAPASPYSTDIGGGPRSAMSLSALLNALDGVSSSEGRLLLITTNDTSRIPFAEVLLRPGRIDRRIRFQPLHAEQVRAMEASFQQALQACPCSAVEDLRLLSASLRAHEDNNSVTRTPAQYQQKLLDAIYAFFMSRSQSESKGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3M0</accession>
    <name>A0A088S3M0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_356530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMA16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703581.1">
        <property type="nucleotide sequence ID" value="XM_010705279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3M0"/>
    <dbReference type="GeneID" id="22579681"/>
    <dbReference type="KEGG" id="lpan:LPMP_356530"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350074700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_356530"/>
    <dbReference type="eggNOG" id="ENOG502S3U8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270284at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.170:FF:000004">
        <property type="entry name" value="Protein_of_uncharacterized_function_(DUF2962)_-_p utative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.170">
        <property type="entry name" value="Translation machinery-associated protein 16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021346">
        <property type="entry name" value="Tma16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038356">
        <property type="entry name" value="Tma16_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13349">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13349:SF2">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11176">
        <property type="entry name" value="Tma16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="228"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="250"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO02781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="266" mass="30624" checksum="D1B3D3721E65DDFE" modified="2014-11-26" version="1">MRRALLNSAREKRAVPHPRDRSVRQLEKKEKRAIRLDAQKTRLKTEKTLQLMRFFWFREQCITLGYTTAAVPDETVAQLVQLYVGRNKEEMSALQMQRNPPVGRIKALEATLQVEEDELNSAKGLRVPNMTDAHDVEILTEIWDGTQETVTVVPVTGFSMQHRTPPTKEALEELLQRLRPVAEIRKEAPVKLPKGVIKFHAAQPRNKVSVKKTEDTAVSVRLRVKAREEAKQQKRLTEQRRAAMARRRGVPTEDDAKVRGEPTWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S4K1</accession>
    <name>A0A088S4K1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_354320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703365.1">
        <property type="nucleotide sequence ID" value="XM_010705063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S4K1"/>
    <dbReference type="GeneID" id="22579460"/>
    <dbReference type="KEGG" id="lpan:LPMP_354320"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350051300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_354320"/>
    <dbReference type="eggNOG" id="ENOG502SG0Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="832" mass="92249" checksum="3D556143A60B59BB" modified="2014-11-26" version="1">MFRKRRSSKEMAPEVLLLLRHPSRYPGDLLQGVVIVDIPFPSDILALEVRICGDENSILGGLIMPDKNPEARNTIYYDQFITLRGIDHDLLEMKRSLQDSRRTPVSRGAVARESIWLPDEAQGLRTGLNGTLCLPSSSTGDEVPEFAASMVHDASGATVHLIPGIYSYPFSLVLPDNLPASRELSRGSDGRCVLQYRAIASLIMTSGKIHTSVTGFRVNPLPVQVQRWYQLHGAEQQLCGDAVDGSTANGNEADSRPGVMSRLMSSAGTVRASKAKEDRENVHQRRLHHYLQFSEDQLALESAVYAEAAGRRAKEKKHRMRERNARENGSLLMAAETKTVTKKGTSRKLRSQQELEEVEKRSLDSMDDAVSAANVLDYDANDEIYAFVPDVCSPTVAESINGEEEDGNVSVHHSKEETSVVRSSVLEVRGERRKWRHHGGENDVINSPTHTAMVKSNVVTLTCTPSEKDFPTHLEVRHANRTEVVSREAAGGSNVEERKGRRSRNTKLHRRRRRFQPPPWNQEFFINLRSGFLRTGKVRVVLSLRSPLVTVGVGKVGASVLIDNSDGTGAISRVKYSLVTRCYIRSKAEVYNFQVNTVETNCDVAVEKGSVLQLPEVELPVSKSTPLTILTEGMGTLTFLSVRLYVNTTLKTFSRSVATEVVLVSGQDILNCSRRLLRWSCFFRRRRGEDARDITVHPPTINLSEKNSKLHIMYTGNRGATEDPDGFLLQSNDTDMSLMAPAAVSRSMRILRRSQRISQATPPIDTRVLTRALNYEEAVFVPHDDDDVMGFPKHMDPIAGLNPFAAPACDGKSTLTAGDSDKTLCGEVLPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S4P9</accession>
    <name>A0A088S4P9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_130470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697129.1">
        <property type="nucleotide sequence ID" value="XM_010698827.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22573157"/>
    <dbReference type="KEGG" id="lpan:LPMP_130470"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130008800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_130470"/>
    <dbReference type="eggNOG" id="ENOG502S3BK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273165at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="439"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="628"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="799"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="900"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="740"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="439"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1531" mass="161305" checksum="78B0B2A8F089A514" modified="2014-11-26" version="1">MNSNDAVSSVVYRATVPSSIRAIAMDPVEPVVWVAVGDDPLAALRLSGRELIHSKSVKDIEQVHCMAVVRIAEERATTFKSDSTSPCATRTLPKAARAGKRKKGGRNSSGIRKSGKLRAGSSALLGRSLGNGGGGEADMGNPWSSDDDDDYGDDATTSASPLGHERQGVRFSNYLWCGLSRGHVAVVNMSNLEYQLIHNAHNQTINKMWYWEACNKVWTAGREKGVNVWDPQRRVVLKRRNIAAILTDATYAESTGKVFAVAGDACVRVFEPSGENVNVPKGQENRIRMKLDAWVIQYHRNSGLVWVGLARGSALMSTSTLDVVRTLPYTFSAILFKGNYAIITGQESPNAEGRLMVLDVANPREPSVLAYSKFAGPLPLGLHIVPRTRFAVAAQDDPKKGCMMTVFVYDGSVMPTHATSSGSAPPQRTEWVPRGAATTATVGSLSSPAQLTQTPDHPNGSSIITSTPVPPAASNIGTYNAATAPIVDRATLHRGAVVKTAPDNRIDRKLAVEADRSSLVEAIAPDAQDIKSALKHLVKTTDEVRQSLVQQRSAEATLADFSRVLRGRQQWLVEQGSLTNLPVLPSAVADRIDRDYATIEGKTIATSIEQLQQLYTVALAKQQQLLHSRDAGGGNGDESRGVATSLPAESSARVLRMSSSTVLTSPLVLGSNAKDEQHDLLGSCVVGDAAAAGSGHHQPGVHPVEDGKLPEGCSPSQSGISVPGSGSRDAALPPWALQLASTLQRERALHSQQLNALQLQMERLVERNTALSAAFARLQAHVAALGQQGLALAMGAESTGSTTAGSEKSPLSFSLQRRQPSQAHQLSQPSSRQYKVTAALFAKLSHGQYHKPKYVRRSTDLLVKAMDEVVRLAQSLRGSSGDRDALGGILAMAHSITGTAGTDSFDDPDGSADTAPHTQPPCIDDASLSPTSPPVVLPLEAPLSAEEVSDTRGEQSSSTAVDVALFEHPLTSLLGVCSMAEVELRNLVERNAEVASLWARLQSIRSQPRDADSGHHIMEQHATSAGPVADVTADNAKAVEGQLPLRVPIAGAAADASVAGATPALLTGLMTARVLQAVCWAECAQTVLHELTHAGSMNNIFLAGCVHNAIISPHATTVGRCGGRASSGVRGQGPLEVLGYESTQEQSMVLAKVSQMSKSATLELLNTSRIREELQQQRCLGEGKEGINGAAAFAKSDFRLHRLPGALRWSLTALRLLFLFVSDAEAHLLASGSHADDSEASRAAAKVARAAGGSRKTSAIPRGGDDAAATGALSAVAVAMTHWAMFLLNLQADLTAVHHAARLYHAWRWGPSALSLTAAATSSPPHRTGGAVHDRAGTARSGGLGVSAHSQTTEDACGPVSIGAPAASDSLASLAASLSTKGKLLLLYMQWHFPGFATTSTDRAVAPAGSANTLPGSLATVSSSLSTVGLPALFRPAEDNDIATSAAAVASCSASECSRLLGDTVVQARQLLSRARLLLGYTHAIRARALMALGESRDKAVVQVIASFALTAAPDLDARVPTEQERAFLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S527</accession>
    <name>A0A088S527_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_140240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697259.1">
        <property type="nucleotide sequence ID" value="XM_010698957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S527"/>
    <dbReference type="GeneID" id="22573291"/>
    <dbReference type="KEGG" id="lpan:LPMP_140240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140007400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_140240"/>
    <dbReference type="eggNOG" id="KOG3275">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="672793at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01277">
        <property type="entry name" value="HINT_subgroup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039384">
        <property type="entry name" value="HINT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648:SF1">
        <property type="entry name" value="ADENOSINE 5'-MONOPHOSPHORAMIDASE HNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="HIT FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="6"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="2 3">
        <location>
            <begin position="98"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="1">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN96606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="142" mass="15647" checksum="8BA1510C762C5C03" modified="2014-11-26" version="1">MAVNCIFCKIITGEIPCAKVAETSRAFAFMDINPLSRGHVLVIPKQHAEYLHELDMEGAAEVGVLLAKTSRAVAGSDGSMQYNVLQNNGPLAHQEVPHVHFHIIPKRDGETGLKIRWDTVKAASNELAEDAKRYSEAIERIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S5I6</accession>
    <name>A0A088S5I6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/beta-hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_150370</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697414.1">
        <property type="nucleotide sequence ID" value="XM_010699112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S5I6"/>
    <dbReference type="GeneID" id="22573453"/>
    <dbReference type="KEGG" id="lpan:LPMP_150370"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150008700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_150370"/>
    <dbReference type="eggNOG" id="KOG1516">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6495301at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049492">
        <property type="entry name" value="BD-FAE-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF33">
        <property type="entry name" value="KYNURENINE FORMAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20434">
        <property type="entry name" value="BD-FAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="BD-FAE-like" evidence="4">
        <location>
            <begin position="570"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="218"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="260"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="337"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="462"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="836"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="367"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="390"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="484"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="839"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN96761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1063" mass="116070" checksum="EECEB50F6F0406CA" modified="2014-11-26" version="1">MLPYAVRQLVWMLTSALQLLYALSTGVVWVAQMLRLFVYSACVAVCFIPHCWWYLTSPNIIRRVSYRSSEKTKRRNILRVLEAEGVDLHEVLRKDSIVQAMQPPHQVQLSSSSAVALAVARRRRRLETAAATGQRDGAGKDCTGCQSRQWPARGPLTPRHHRLVPCRSPSSACREGEAEAPAVDQRMRGFSGDHRLPHAIDGEIDDRALSLLYPTSLSSPLRDGEASGGGCDQRLPPGLNSEPLGRGSDKCDTIAVVSSSLQRRPHPSPSHSAFNGPRHGGIDASTCDPHSVTALERLVGTATCNLNPADGSAMRSLPLRQPQHPQLQRFSIGDTVAQRSREPEGAEQQQQEAHSGPSVADAARAKVQSSLPSSSGTENQPYKLRRSAAGDEAATTRAAPADSMEEPMNRCNHLGSQQHVWAYEGRPVYYETLPKASPSSDPMLRDVLAAFHDAEGVKVTAGLSQDDHSSGPHSRRQTGGATARRQRRRGGAPPQHRRGRAKREASAHALRTPHARTFSEENFFVDLDEEDEEDRMNLHNRATVDIVLPAPLDTIMKTLQYAQQSKRLRRKRFPIVIDVSGAMWIIGSHLWSTMIARVLAQRGYVVFCPDYRNFPQTTMEGMTLDVSDAIAWVLNNAERYNGDLNNVTLIGHSAGAHLTMMSLLSQAQLSAYRCNAEQGTYEGVPPPSDVAYNVPRYNPRESIHRYVGLSGIYNVEGLVNHFQAKGLYRDVLYQIAGGKAHMARYTLNAYFDDRRGGDTGEVLPDNIFDFFPQRMFFMHGDADKSAPIGESSSLVGMLRAAQERYTQRRSVRNEEARRHAQRSRRLLPGVLAAAAGEARSSSTAPTTGVSTSASAQRTAAVGFANVGSTAMTAAEGPFGTAVKLTDPSETILVQNSDPFDTDAAPYLPQQQQPYATDAPLFSILSPMSISPIIPSSREDRAQPPVEVGFLVISGGGHSDAFVDECVAAGRSCCVDFLCDYESAIDLQGNTSEPVSHRLDCEGISGNPLSGSVWTASMTAEDRTPLFGAHASKMSVMPDAVLPLAVPYEERSLPLRLCTMISPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S5K5</accession>
    <name>A0A088S5K5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Threonyl/alanyl tRNA synthetase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_150690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697444.1">
        <property type="nucleotide sequence ID" value="XM_010699142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S5K5"/>
    <dbReference type="GeneID" id="22573489"/>
    <dbReference type="KEGG" id="lpan:LPMP_150690"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150011300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_150690"/>
    <dbReference type="eggNOG" id="KOG2105">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="288942at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002196">
        <property type="term" value="F:Ser-tRNA(Ala) deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000019">
        <property type="entry name" value="tRNA synthetases class II (A)/Threonyl and Alanyl tRNA synthetase second additional domain containing protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051335">
        <property type="entry name" value="Alanyl-tRNA_Editing_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43462">
        <property type="entry name" value="ALANYL-TRNA EDITING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43462:SF1">
        <property type="entry name" value="ALANYL-TRNA EDITING PROTEIN AARSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="495" mass="54058" checksum="4ACA61FF839CC5DF" modified="2014-11-26" version="1">MHSHTAASFRRVGELACQRDSFLRELTATVVSCEPTKAASTEAKKAKSAGDGAAAYDVILSDSILFPEGGGQPCDFGTLRVVPGDENKADSTCSATAAPLLSITNVRRVGDACVLTSPAFLPVGTTVHQTVDWPRRIDHMQHHTGQHLLTAVVERIDTLHLPTVSWSLTHPYCFIQVDVGAYASDPASPYHAYITKEKKISDDMVAKIEALCNDAIIHSTPVQCDVFESLEVYQQEQDRRHQAAAASTGLGEEVLRSRGIPEDVTGPIRIISLDAIDSCTCCGTHLHTLAELQAMYLLHQEVKGTMVKLYFITGERAARQFHTMYQRERQLMPELSGSRPSEFVSVVQRRSKNTADLEKLVKRWTLELASAEAQRIAAAVSSRDSGTVIVPLRRDDVELEFFSEVRARLDATGLRRVVLVSAWATERCMTGTLVNTKDVAGQVFITGGESPADMEKAVQLAKETLKGMKGGSSKLGFRGKGTLKEWDALVAQLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S8C5</accession>
    <name>A0A088S8C5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TPR protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_203560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698558.1">
        <property type="nucleotide sequence ID" value="XM_010700256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S8C5"/>
    <dbReference type="GeneID" id="22574567"/>
    <dbReference type="KEGG" id="lpan:LPMP_203560"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200041900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_203560"/>
    <dbReference type="eggNOG" id="KOG4234">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1872379at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052769">
        <property type="entry name" value="TPR_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="31350" checksum="E22CBE1AD76FD1FC" modified="2014-11-26" version="1">MPAVVEQLPSSDDDNGEPSLAPPMQCAQLDKDSSLAGAPQVEVSNAGTGAESEGRAQQDEAVCSSAERVVDVEECARLKAAGNELFKDGDISEALTLYRKALWCAPIKPVPPRPATTSTPSASRTSDANVPAEGEDAATKCDKGEAEKQPEDTTDYTLTAQVYCNAGFCLMKLDVKEEAAHMLSEAIRHDDSYLRAYIRRAECYYSMQKWSSAYGDYECYEKLGGVLDAQGHAHKAASKAKVDEEMQKMWGELKSLGNKILGNFGLSTDNFKFDKDPNTGGYSMRFER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S8H1</accession>
    <name>A0A088S8H1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine/threonine-protein kinase TOR</fullName>
            <ecNumber evidence="9">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">TOR2</name>
        <name evidence="13" type="ORF">LPMP_204120</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="9"/>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698613.1">
        <property type="nucleotide sequence ID" value="XM_010700311.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22574623"/>
    <dbReference type="KEGG" id="lpan:LPMP_204120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200047300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_204120"/>
    <dbReference type="eggNOG" id="KOG0891">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016242">
        <property type="term" value="P:negative regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05169">
        <property type="entry name" value="PIKKc_TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000039">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000022">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.150">
        <property type="entry name" value="FKBP12-rapamycin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009076">
        <property type="entry name" value="FRB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036738">
        <property type="entry name" value="FRB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024585">
        <property type="entry name" value="mTOR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026683">
        <property type="entry name" value="TOR_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF126">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08771">
        <property type="entry name" value="FRB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11865">
        <property type="entry name" value="mTOR_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01346">
        <property type="entry name" value="DUF3385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01345">
        <property type="entry name" value="Rapamycin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47212">
        <property type="entry name" value="FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 9 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="11">
        <location>
            <begin position="1346"/>
            <end position="1860"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="10">
        <location>
            <begin position="2035"/>
            <end position="2358"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="12">
        <location>
            <begin position="2405"/>
            <end position="2437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIN97906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2437" mass="274312" checksum="C2AB36A9628FD4F2" modified="2014-11-26" version="1">MSSVDSERLAASIRALASSRDERIAFVTEGVKQAKELQGKSVQEYEMVVSSLLMCLESFEVVHGTSLDVFCELTVLDILLSLDLSVIQLSQCNSYLRLCLMAVNEIPVAAAAAKTFAQTLRYSMTTDFVRTQIGETLEWIALSDAKSQPRRICGILVLTEVALRIPMVILPRLSEVFDRVWDCLAEHDEEVRSRALSLFTLCAKLLVNRPATIRAETCDTLMSHLKANLVSKSKDKRIAGLLAFEPIVINSIGTSSVRYEDLSVLLAPYIMGDGANVSADISDLLCRCLVVLCRFSAPQFVTKQLKDTVRFALDSINCNTGRNTAFDMLSEIIPIVGKAEFSPFVEETCEVIKNIFVQSPSPCWKALQCFCIICRDCRPSKMETYVDSCIESVFVWGLSAELIECMRTIIESSGAQYRAKLEESLLDMISVTLCGLPFRQQINAPRVSGSSADVGASEYQISVALNALKQFGFSNSELMGDFLRVSVLPFIDNSSVAVRNAAIYTIVKLLIPPGEKGDLSIARRMCVNTIITRMLVVGLSDPNPVVRHTILSAFTENFYPYLSEQQYLFRFYSALGDESINCRVAATEQLCQMIRYDPSHILPALREEMVVILNFITSTFNMDTVQNGFRLLAAIATRAPQIVVNFTDGICEALLPYFSTLSARSGILLSFLHCCTAVAAAIRKFGSTLLSSQREVALVCELLESLPTDRSYHVIRLACLRFLSATLAPLMEGTSPYVLHPRLFQQLCTVLHKTEESIDIRLEALRCIGVIGALDSHVFQSVNLSEEKADGVSAVVVDRVTHVKCCRIVLRAVAALLDPESKRSAGAREGLLRTGVQTMLNIFEHVPCSKSEISLVIGPLARVIRQLPGGRLFATVLFEFCNIIRYAGVMVLNDASEIYSVFDSVWEFQVNYRFLAVRMLSFVANFEGSGNRHYGQQHSRILPQLFDTLNRTELRPDLKYSVLEYIVRHIDALQPCTEAVVDNLLGAIQNPENPLDFVNHCVVALKEVCLKLYVDELVGAIVRCLLACLSVDLARKTRGRDSVALCNNIMGVFCVLIEEMQGDFLKHSTYIIQALKNYRITNTEFGVMNNRVATGLRCARSPASIQHQNAEVAALLKTCESVVMKSMSRVGEVWSYANLNDDNANSVLAEDRTMPINEQRLINPMKVVPLTKEEWVKWADQFAITLLQESPFQVFRCTAVPIGINAAPLVEKSTQFVQDTLQIAFRSMWNYASSALQAAITDFFRQSFRQAMMSTAVPGEVVTTLLGIVEYMDHVGEALFISYNDLSECAWNRGMLAKALFWREAAYRDDPVGTVESLISLYSELHMVDSSVGILNMASEEQRRSLLQTSLVKLARYTEALKLTQKELDLDAASTGAKSSENVSKGYGYKNGNRDWSRMLHYTTNSDPTTSFSRTEESGHDHRVEVNARLMLCLSELGEYDKVLKQWGIMVDNYKDRVAESDEMHIFFFVSQYAADASIRLQSWDTLEYILNWLPPDMVLYHVSKAALQVVRGNYDDALVSVTNGRKVLLEGLTSLLHESYARAYEGLVVAQQLTEVEEVIVAKQTQKALNSTAHIPHLCHLWEQRIRTMNATVPTWKQVLGTRGLLISPHEDVKTRLQFTKLCRQENARQLEKFTLAELLGFANPTLEQLTSRNANPRVVMQYISFLSDTNALGPDSAFGTESDLIKKMIDVHTKAENSAVLARAYTRLGSKVGLIESVECFKTATLYDPQWFLAWSKWAEANAQLLHTDKGDRTCRNAIEGFIRSIQLGTSDSTLIQDVLKLLTLWSNHCDCDHNLKELRERVFDVPSRVWHLVVPQLVARLDIGSDDSCRLVADVLTNVGYDYPHTLVYPLNLCTMSDSERRKRYSNEVLSKLQERYPVIVLQGRLMIDELIRVSALIYEQWYDKLEEAATAFFGRRSKEEMVRTLLPINETLTKVPETVVESEFLSRYSKRLTEAWEWLRSYSSTRNTGDVQSAWKLYHSVYGDIDKQIKASDTLQLQFCSPKLFEARNLSIGIPDARPVREESVAKVHRFQKDLIVITSKQRPKRIGIITDGGKSQKFLLKGREDLRLDERVMQLFSLVNILMQSDSRTSKNLGFQIQRYSVTPLKDNVGIIGWVDGCDTLHEVVKHFRERKLIPVELEMRMLNQIITFDNTKAYDYLTIMSKVEVVEFLSDHTSGQDIRKFMWNTSPNCEVWYDRRRMYTTSLANMSIVGYILGLGDRHPNNIMLQRASGLVVHIDFGDCFEVAMTRDKFPEKVPFRLTRMLRSALDVSGVDGAFRACSETVMCVLREGSHSVLALLEAFIQDPLISWRLINRQGQEPQSSNDHKTIEQQVNIANMNKATSTAEEESICESIEQRNTGSFSIAKHLFGEEVDVVHQGVFLFNRLSSKLKGQDFIAAGTEPLDPRTQVGQLIDEATDVTNVAQSWSGWYPFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S8V8</accession>
    <name>A0A088S8V8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein S17-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_205750</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN98066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698773.1">
        <property type="nucleotide sequence ID" value="XM_010700471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S8V8"/>
    <dbReference type="GeneID" id="22574787"/>
    <dbReference type="KEGG" id="lpan:LPMP_205750"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200064800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_205750"/>
    <dbReference type="eggNOG" id="KOG1728">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275814at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.1000:FF:000004">
        <property type="entry name" value="40S ribosomal proteins S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_uS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032440">
        <property type="entry name" value="Ribosomal_uS17_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF9">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16205">
        <property type="entry name" value="Ribosomal_S17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS17 N-terminal" evidence="5">
        <location>
            <begin position="18"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN98066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="173" mass="19938" checksum="71DC8C12855CEC2D" modified="2014-11-26" version="1">MSAAPQYYHAHQVDATIQHQKAYQRQTAVNENMHRSSRKHVNKSGHIRYAKKIGLGFKTPAKALNGKYIDRKCPFTSNVVIRGRILRGIVHSTKMHRTIVIRRNYLHFIKKYQRYQKRHKSLAVHCSPAFDPKQGDEVVVGQCRPLSKTIRYNVLEVVSKSAADKMGKKFAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S9C5</accession>
    <name>A0A088S9C5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_211480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698933.1">
        <property type="nucleotide sequence ID" value="XM_010700631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S9C5"/>
    <dbReference type="GeneID" id="22574970"/>
    <dbReference type="KEGG" id="lpan:LPMP_211480"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210019300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_211480"/>
    <dbReference type="eggNOG" id="ENOG502S9YD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264866at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.20">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="350"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="444" mass="46242" checksum="A1D6FE9119DA4462" modified="2014-11-26" version="1">MPQGLPKPRPLALQRRSGRAFGSDAAEPGKSRVAGTTPIDAVRLQPPAHPERNGQRHTSSGASLSTAANDAAATRSAPVGVPGAGCRPSAEQQNQQQRASNNPPYALQDMNELVFTDPQNWKTEEELPGVVWSLLEGVALEAPYTSDLWTQAYVCPAGLLQAPKGNASALPAMCLHREGQQRTNGFYACVRCGTPVCDPSHQVIPASGSLRGIAVFDALNMSGVELRVAMPTVLDKAARLSREGCSSLTSIRVAISHDRPEGAAELDATAGGLRFLVHCRHCNGCLGAMLLGEVKCAPSADAPRPSVLAVTSAASPATALFCANSVCLEYMPYRTHTRLDQAILDKPTSDSEAGSSGRRGGRASMLGGASAAVSVEPGATLGSLFIPQPRSVAWGVGEDVDGDRSGKQGGTSYAGDDTSLDSLLEELNPYGDSAPISSSDDSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S9S6</accession>
    <name>A0A088S9S6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_220980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699098.1">
        <property type="nucleotide sequence ID" value="XM_010700796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S9S6"/>
    <dbReference type="GeneID" id="22575144"/>
    <dbReference type="KEGG" id="lpan:LPMP_220980"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220013200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_220980"/>
    <dbReference type="eggNOG" id="ENOG502S5WQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="239465at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="216" mass="23879" checksum="2B9C7247F615DFB0" modified="2014-11-26" version="1">MNSPAPLTEAEQLDLLVAGERLDDTEAQDTTRFLGTNRRHMYADGLLSCAVYTFSGLQHIQGQSNALTLLTMWTVGTTFLVDVAERKHLHESLQSTLRIATATSKAEALVLHDQPQDDTTTTSTLGKAAVAPALSTASGTVSSVRMKAAPQDKEKLAEQQRKVFLTQAVASWVWMLASFQQFKVHKRLKWCGYSSWVGLGCTGYYTTRHLYNLLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SBL5</accession>
    <name>A0A088SBL5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Kinesin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_252030</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699773.1">
        <property type="nucleotide sequence ID" value="XM_010701471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SBL5"/>
    <dbReference type="GeneID" id="22575851"/>
    <dbReference type="KEGG" id="lpan:LPMP_252030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250022400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_252030"/>
    <dbReference type="eggNOG" id="KOG0244">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000196">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="5"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="530"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="609"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="944"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="318"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="544"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="609"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="962"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1004"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1028"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="77"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN99066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1043" mass="112739" checksum="384E385E5A7D5418" modified="2014-11-26" version="1">MSSSSIKVAVRCRPLFGQERPAGGLDIQNRRILLDSKTYDPDFTFSPASTQEDVFQACRPILQCVKEGMNGTIMVYGQTGTGKTYTMLGREGGEHGLVHMVVANMLEHVQQKTVDGAQCALTLSMIEIYNERLTDMLSPNGEEEVTLISGFPRFTHKATLCRVNDTIETIQRGLSWRHTAATLMNERSSRSHVVFIFDMEEYNAFTEQTDVAHLFMIDLAGSESLKKSQASGVAAGEAGKINKSLLALKSVFLALSNTNEATRPNHVPYRDSKLTEMLQDSIGGTARTLMIACISSVGRDIEETKSTLLYAVKARSIRNAANTEKEKLLVRLRSMEVENQKLRNRLQERVSERGGYYVSKEEHEQTQEVAESYDKLKEAVEQLMQDRQSSDARQHIWESQVKVLQGLLVDKEAELQNFKEVYHEALKRFEYQATILQRMVRGGVAEAKDVVKSSFADNYARLHAWRTELLNALEEPVPTTLPSLPPPLPHACSPQSDAAAGTAVVNEESVQYQKADESASRCALNVVEATTPDRRSCTPPPSQALLSGGTQSLSQPTGSRGIAGLVPSGSPSRTAVAAAAVSQPGRTMVATAPYSARCSTALPLQRGSATSGALSASVSPTRRAGRPRGGGGGIATNSGPRRCFAGNNSATSALRGSGAPPMTLLPATAITEVLTQDGSEEYRVSTMTTNVVAAPAPLPVSRTTSTSMAPPAWSTVIAQYDKQCLRIVHRLNEAVEAMLSECLQSLADYKEHAEQVELKRRRGVEEICQRLRSELDSSLRRLQRVEDVALGDVQEAREHFGDRLRLKAKMPFLADAAPFQLAVRDACAEVVRHATHVFPHPSTPADAEAALDVIVRNVLRCSTAFTLQSLDPLSSSDVNAHATSVAACGGSSSSPQLTGLVPMSPLTSPLVYESPAAASFCSLTGSLGKEEVLDCGPASVHLLQGSRGTTPVSSSQQQQQSTRPSSLRGSATLTAMPVNRNRGGDGRRGGGGSNLLRPHKRTRSTATSSTSSGRGVPRDSNASIRSLRNIDRDTDARSREGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SD88</accession>
    <name>A0A088SD88_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Katanin p60 ATPase-containing subunit A1</fullName>
            <shortName evidence="7">Katanin p60 subunit A1</shortName>
            <ecNumber evidence="7">5.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">p60 katanin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">KATNA1</name>
        <name evidence="10" type="ORF">LPMP_280400</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.</text>
            <dbReference type="EC" id="5.6.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
            <location evidence="7">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.1" evidence="7"/>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700383.1">
        <property type="nucleotide sequence ID" value="XM_010702081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SD88"/>
    <dbReference type="GeneID" id="22576485"/>
    <dbReference type="KEGG" id="lpan:LPMP_280400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280009500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_280400"/>
    <dbReference type="eggNOG" id="KOG0738">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5334845at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008568">
        <property type="term" value="F:microtubule severing ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051013">
        <property type="term" value="P:microtubule severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21748">
        <property type="entry name" value="Kp60-NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000142">
        <property type="entry name" value="Katanin p60 ATPase-containing subunit A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000159">
        <property type="entry name" value="Katanin p60 ATPase-containing subunit A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03023">
        <property type="entry name" value="Katanin_p60_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028596">
        <property type="entry name" value="KATNA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048611">
        <property type="entry name" value="KATNA1_MIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF19">
        <property type="entry name" value="KATANIN P60 ATPASE-CONTAINING SUBUNIT A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21126">
        <property type="entry name" value="KATNA1_MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2 7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="271"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="189"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="279"/>
            <end position="286"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN99676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="523" mass="57550" checksum="4648956F423F571B" modified="2014-11-26" version="1">MPASVASEIVNAVHKARNCALYCDYKTALQYYASIRNEINSHICSLDDVLRAPWTSLLEELESEVQIIRDTQAELHLFIDPNAAKRREPPDYDENPGSGNAERAVVPRTGIKKKARIGASLTSSCGPYISAQNERLYGDKDRFGPAEGPHISPAMRQSARSGPFSSNNGAGVAGRHVAGAAAVGFRQGAGATNGTGAAARGRMKGRSAASRFAGRPGEEELVQLIEADMHIGKLPVTWDDIAGLEEAKRLLEEAVVYPVLMPDYYQGIRRPWKGVLLYGPPGTGKTMLAKAVASECNTTFFNISPATLTSKWRGDSEKLIRVLFEMARHYAPSTIFIDEIDSLCGRRGGNDEHEASRRAKGTLLAQMDGVGVDTDKIVMVLGATNHPWDIDEAMRRRLEKRIYIPLPDATDRVELFKINTKSIKLGSDVDFVKLSNLLEGRHYSGADITNLVRDAAMMTMRRFMKEADKTTLKENAAEIGRQVAEQPINMNDFLAALKKVPSSINADNVKKFEAWKKEFELNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SDQ1</accession>
    <name>A0A088SDQ1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_282530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700593.1">
        <property type="nucleotide sequence ID" value="XM_010702291.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22576698"/>
    <dbReference type="KEGG" id="lpan:LPMP_282530"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280031800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_282530"/>
    <dbReference type="eggNOG" id="ENOG502RZ30">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6344460at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1470.10">
        <property type="entry name" value="Photosystem I PsaD, reaction center subunit II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053233">
        <property type="entry name" value="ABRA-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21715">
        <property type="entry name" value="RH04127P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21715:SF3">
        <property type="entry name" value="WW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="75"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="485"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="636"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="953"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1024"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1224"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="348"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="424"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="808"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
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        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="959"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1024"/>
            <end position="1047"/>
        </location>
    </feature>
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        <location>
            <begin position="1230"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1253"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1304"/>
            <end position="1318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN99886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1339" mass="145543" checksum="4E19E8C33BB4D139" modified="2014-11-26" version="1">MPPVRNVKHETDVVLPKAGETYVADDGTVSQVLEDHIDANYEPTEEEVLEFADWIGMKLPQDSEFLWLAREGLKTPLPKEWKPCSTNDGEIYYFNFKTGESSWDHPMDGIFRQRFEQEKARTCKPAPAAAGNTASRSISGLTSSIHSSNTSVMPQTHVMMTETGVLRRDIGPGTAPGPSPATTSVSGSSKGPGAGNARDEDKPFMHYPLQQQPQPTSVTTHTSAKPQSTTALSNTTAATHSNPARASTRHAPKKVGTTEVSSAASLRIVSEAERALEERVQREMQLALEAERSKIEDAHRGAMFTLQINFDKDVAEMRRADAARRATASQQQVEERERCLQQTRSMCEEKYGDELRSLEREAESYATKLQKLEAEAARATSGNTQRAIIEAELKTALVKQRADAEATAKRQHDTAMATTQSAHAAALQKIHDEERDRVRAAQQAWQRKFDEEERVLALKAEAERKRLEGQLKEFEGKLASVATRAGASTTTCTPPAADSSLPGRGESLSERLARVAATKAARLHDIKAAAAREQSAVRTECETALAELAEQVLLAQQVGRLLPTGAPPIDLLSRGASYSPDGSGAVTVQGGARPTPRTLSVAFAQELNRIRLARGKERQELLAKLRADREAALATIESPSHSASSAKSRRPDLNGGADAAPVGGSGSRPTTVEELKAAHTAELEAKKVLYANMEEDLKQRYARELADAAGATTATQQSTLVAKAVDTEMNLYTQEVTARYDCMRAEAAAKCAKALTDHQLAMEAYERRKLETETRLAQEQREAQESFIQDRLDTVVAAEKKKLATDYAAAMARLAARYDEERDALKAEVEEEMEAYEAAMRQSIMTSVTTTGASHGRDQGAAVVVARVGTTTAPSSTAEARGGTAATVALCSQAEKQHADRHAEWMSWKRLQAAQRAELEEKQSTLQAQKQRVERRVEALKEEVAGLVATVHTAETQQPSPPSASGPSSPPPASTSATVTPARGYLRSVHEASMQDLEQGYRSQEASLEVELRTWREKTRALQQSQTLQSYTSTSLSTSQQQLLSDTTHSEGAAMRPASSPYVLRRQPSPIATAAAGVSLLNTPTIPMALEDSSLQPTIRSSGPLMKTEMVARGPSVTTGVSGTTEAVLSYQQRQYILQQRQASLEAARETWQLYRRRKSELQQQEQSRLSLTALVAPSEDGHRYEGVEPRTLSANSGVSRSRNEFLNLLLTCLIERLDTVTRQAMEPPQRQNRTQSATRAGAHAAMVSSPHARAHSVHSHQHVARGPPQQERAMSRAALQSHHSMLVNAAAASASPKGLPPSTRASFSDSTKASQYIQHGRRGGGSVGGPSFNKVSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SEC9</accession>
    <name>A0A088SEC9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">REH2 DRSM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_291690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700774.1">
        <property type="nucleotide sequence ID" value="XM_010702472.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22576932"/>
    <dbReference type="KEGG" id="lpan:LPMP_291690"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290021100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_291690"/>
    <dbReference type="eggNOG" id="ENOG502RN4A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273195at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058737">
        <property type="entry name" value="DSRM_REH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42260:SF1">
        <property type="entry name" value="DRBM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42260">
        <property type="entry name" value="DRBM DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26536">
        <property type="entry name" value="DSRM_REH2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="REH2 DRSM" evidence="2">
        <location>
            <begin position="162"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="REH2 DRSM" evidence="2">
        <location>
            <begin position="407"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="REH2 DRSM" evidence="2">
        <location>
            <begin position="870"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="domain" description="REH2 DRSM" evidence="2">
        <location>
            <begin position="1111"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="929"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1055"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2054"/>
            <end position="2074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="555"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1070"/>
            <end position="1082"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2206" mass="239152" checksum="43ABBD32D6757A43" modified="2014-11-26" version="1">MPRRLCVMMRRRQVDVVALYTYPCGGSTLPLLENYALPLRNGSFMAYRCTPPSSPLRALTHEVTAPRLVHLRAAAPTATLVQRCFRSSFSSQRHPSTASATAHDKDNTDDWSSIEVEVLMPEPELAASGNSGTVFTTDGATVAGHSSCVSPTGSSRLATTIETIDTIDSYAKAKVSNFVRRLLQPSVSGASGATPSSSVVDLEVRQVQGCGKAAQYHARWRLPLPVEFGERYGEGFAPTAKEAEAVAAMHAERVIDALGFQLFQLSSKQRKHAEAARAAGRWAPMPAANIITAASSSDAPITAAEVVPPPDTPSPPPLRLLGLSAQQRQEKELQIDRVHFSPVQRGGFAPLAFTLASPHYFDSSSHVRIERFFRVHRTSLKANLRLVLLKGCRSGAMKDDDADKGSKTRQRLSMPEGLFLAQLILPLPVRFGKRVAMGKAPTRKEAVLLACMHAELIIDAVGFALYPDNRENQAVHAVECAKMQRWCAQPGDFTYRYAAPSPPPMELVEELHPSTVAAATVVTPGPGRAVIEAPLYSRAADGMTYSRRDGGGSGASPSPRSAVGARAGTAPPSEESILLQHQQAMLAVRYFIDEPSLRDFESAHLLLERYVGQFVSQPAPHAEDSAYTSAISPTNFLLAELMLVEELGQRDRRVFRATITVPLSTPGAALTAEQDVDVSSPLPYTQSFVAIGVSYTHRLAEVAAAVHALRTLAALNRLCLVRGNAAMAQALESFAMRAQIPLYDPAQPMLDPSQLPPESLPAPVRVMEGFVGRIAASGLNLRERRHLSKAVDTENASGHFSARIPLLSEEAGTLVNTLNREDDLLRELRACQERLPRMHWDAAPDADGRIIVSPDQDVHKSRMYNHTLSSVRQPDVMATTRLRDYLERHGKSPDMALSIVRACSKREGSEDGALYVAKVVLPVTLRHRPKAKRRPPLVDESHTDALSSISSPSSEPQPPMPEYIAQGEGPTRDDAVLLCAAHAEMLLDAAGQPLYDHPLLQRKHADTARALGRWAPLVRGAALPPESLHRIPPPLRKVTSESAVWARVQEQQRTSTCEAVTTDSAEHEAGMPSIASSTSSAHAGATAPASAAGVDDEALCDIASLQFVYHTDISQRALRQVAEYFANNGSDVYRMVRQYAVRHPELGTIHRAIVEMPLPASYGRRYAVGCGATKRQALFLCCKHALLILDALRIPVFSQYGRQRRYARAAAVTGRDAPLSGKARGSSDTPSPPGLYYLTTCAAAKEKPPEVPKLPTLRDRRVLTLWSTFVQHCASYVTRRRETRVMEAVGVAGSPRVPRSNLVAEDVTSDVAGDMPSDKFARRQLGDLCRTARLPDPTDNAPSQSLALSLNERRFFTCKELVGTPYTMRGVSDVTPADSRHRAFGHGIQLLLLVVRPNSVSTPTPRRSWWDGQQRTLCIIDLVRNQITPHGCLWVLRMWAAMHYPPLYVRVMLRKAELPAEGRGKVETHPHESAAATLPQLASSMSAPGTSCLPTTYQGIASVAEFRDGREQVLYYAVCETAGATITTPPDSVHRALRQLLSDVQRVPTMQTLYRFLSQQPQLHIPSFRVLADPEDVVHRLHAVVCHSQSSARTTHPAEPLPVGHVAVLLTLLAHNERPTAYFYTTWCVEMLQMWVGALSSAYGWATTKEGGAGCGETPHHPLPSTLELTFASYGLARAASSSTKALPTQAMKFRPASPAVPTPLAGALALLCRCLPQLSDVPMNKGNGKNVAAAQVVRNTASSVERDRTLPLQLAHLILMGLLLGCTPWAVRAAAIVACAEHSLEWYDKYQLLSAGAAGSDTSAETPPLPISSLVPYVSVDVTDAVLASLDTTVPPLPQVVLRYASEVEERLEALWVEASATAAAGETSPLPWLQPPEEWCACLGKADVKKRLSSPETGVLTLAERRILRPLLQCAVATSAAPHAVWVRAVRPGREGDGDEVGHDGTGGSWDETEAPVVRLIFQHRHAARYAAVHVSTRDLTQVETIESAKDISEMATCFTVFGCAVYPTESLMTSTLEQELASTLSHLSHAAGDMEEETRANDDDADDAAYAANEDEGDEEEVGKFDDADDDDDDVDVGQFTRVFGACVSPLAAALVAAAPTRSASLQSHHSTSATPDDVVAGGALRAVGEHLPMLMTAFQETVPLLVHRHGSVQLLSSLSAQLRSRVETTTPFTPEERRAISQLFTLTVRSATDGESRCDEAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SEY0</accession>
    <name>A0A088SEY0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_301320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701162.1">
        <property type="nucleotide sequence ID" value="XM_010702860.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22577186"/>
    <dbReference type="KEGG" id="lpan:LPMP_301320"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300018200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_301320"/>
    <dbReference type="eggNOG" id="ENOG502RWCX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272946at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1381"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1542"/>
            <end position="1594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1393"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1542"/>
            <end position="1557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1575"/>
            <end position="1592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2003" mass="211974" checksum="796C1CFD20C79F0F" modified="2014-11-26" version="1">MPFPSAASFTQAKWLAFFAELTAKLTHHNALVVMEGAELLKRLLLSRVSIAAVLQQGDLLLRLLDAWRGCVLAEYPHEFLHRHDETAFALSAPPPPSAAVALNDELSFVLAESISQCIDLMVSLHTDGDPYYSLLVLARAGPMMEVLVDVIQMAPPQTYGITASLLQQLLALPLGRDPLGSMCIGDSVDDARGEGVRLGFDKATLAQLRKSIPLQQHVHSLAEAVQEHRVLLQHATDTLAELLAVQQGPRRLAAVSLFNQASKRLRKCQLRHGCGATAAAFVSGGDDPPGIPPYSRYSARESTVDDSDLNVTITGAALAPRLSPSPPPNAVSLCAMDDLEQGLRAAEKRRHSSAAALPGKTEEARGAAAAARSDVSLAKEAARSPSPPAANPIMESDKSPAPPSHPHDVSAMVDAEPPRLVCAVPLTMAEESLRHLAASRSHDAFFAAFDWLWCLTVADAPVVGEALTPEMLRCGLGRYLMSAPRTRRDRVLFTLLLLWIGHMHSVSALREETHNCVLGLAASALLPMLRAELAEDGGRTSPRQARSNSGDHGISSLAVSAITPTNTNIAAATSATMLSAQAAMNHLDYGGVGADPRVTGLSLHPSLFRYGEGRDGGSDPSVSGSALLPYATTRKAQEAALLLRPSIGVILLSFLLNIHTGAVAHMQRAWVLQGRVLEVAQMAVRRAQGCRSVLLDTPTSIDGALSDEVYLEYALRSVRTDATTVAVLGCRLVAAVLGDEVRWGAAAGDRLAVTSAPTFVPAGKALSDGSDTAASIQAELALSAQSLIPLLVDVAVSNPDVTAAQESGAASSVHHVPLNLRCSRYTSLGECALVALDACLQYHAQAGHLRSRRGFPVCVSSFTIEDLVRALPSLTGVSQCSVHPPVRAVPYRLLLYLSQRLEEVLVVLRYMPSLASAAVSRVLDYGPRAAQWEAAAAAEWLTVLVDLLIGAETVTQAAAPSCEAKPPSPSQQRRRLPTGAELLNEYFHFDDSPLSRKLLVTIASGRRSTSTGSAYAVNALLQLATHLQSYLQARRRRTLHERHCHPQQLSPSSLCSATREGVAMEEAVTFPLCPAGASSIAQWVLLLQGITADNRRLARICRAFKHSIEGDHRVTCRGSSGVIKDACSRAVTAAEQIALQYNFTGTLFRALEALLCDAAAEVQAASLSSWILCDAVAAALTLPTPSNVLGMLSRRFQAALAPEAGATDAAHSSPSWALPPALVFGYQAATQWASRVGASWLTGSYGCVAQTEVGTSGGARVRGGLPLKQGCVGLVEDICTGALSAMQETSLGVSQRTRCLAATLLSAVVDACPAEQLGVLESHGAALFAASTTLQRLPCVSGLQCRLLRRVHSAAMRAATSGDGWLDENITSLKHTVDSFKEHTRLSSSSAKKGGRNSHRRQSPQPHSAKQAARDLQRFQVLVSLLTSLVSCAGATVADNAVHTSNPRAEDEEKSPAGRQPLLTSAQRQALCAVLCDALRVDQLQPTVVLALRSMAGTHEGRRCILTEIASTGDPLGRTLFGRLLALTLHMPSRWVRADSASGTGLSSHAFSPTSASQDRHRRLRSASSPQHSPSITCAGATAASSASPSRTLPHGGTALCSDRGTISAVGCDVCTALCGLRSGEAAEGATALTDAGPSSVPTSSNVFLSAFVRHRGMEYLARAVVEADREMRRHGRDLAVPLHWLRLAAALSLHVSIAKLFLQESDFFSVLLELAGTPASALHAPAATLALLAIRNVCFADGLKSALCQDARVLLTLKAAGMGITAVSQLIEWRPQPSPSPRSKRLLTAARPTVTGGAPPLTSRTGAHLEVMLREDVIDMGNKTEVDWGKQACVYARGMTQFGEEPSTDRRDPASCDAAGVVLTVEEKSAGVVPGGAVGVDRVAAIPLPRHLFGDVTNRSRAAEVEGSLLEIDATVGGGSPVKRVENEMLPVLVAATDSEVHRRRYLAATAVVSLWFDNQRGRSAIAGVLAAEPCWSMEDVQAAIKAPVAPPMSTKAERGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SFC9</accession>
    <name>A0A088SFC9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tetratricopeptide repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_302950</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701317.1">
        <property type="nucleotide sequence ID" value="XM_010703015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SFC9"/>
    <dbReference type="GeneID" id="22577348"/>
    <dbReference type="KEGG" id="lpan:LPMP_302950"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300034200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_302950"/>
    <dbReference type="eggNOG" id="KOG4626">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1926212at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050498">
        <property type="entry name" value="Ycf3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44858">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44858:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE SPINDLY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="92"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="411"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="445"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="479"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="513"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="547"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="581"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="615"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="649"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="683"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="752"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="238"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO00517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="849" mass="94466" checksum="412251BC5DC47EBA" modified="2014-11-26" version="1">MRASTLSLAGATTSHLTISHYNPCLSPEGAVARYTDQIQRGTETHLTRLLRAKAYVQLHNYASACADLESWIQKTGYTPPDTSGDVAADSLTEALFYRGVCRARLSQVKDAVGDFTEVLQREPEHRRAQYERAACHARLDDYVNAIADYEAALQMDEVGGKKEKLHRYRECRRCSEQQQPGQTRSESLRPRLVPLPLGSFAIRSPSPVISPLLQQVSTLGSESAQLVNGLLALEQTTPRSPVSSRGSAASSGRRVSVEEASNSAVATVSLLKYTTPAAATGLTSLSEALGRRYSQGHSHHKHYYLEGDSSSTESSPDDSVMNVDKAVKVVNTARKHEIGASYGPHCEDSESGQDTLTAMDPTCILSSNSTEYDERLPDDEVGAETWQRHPQREASHTAASTATAGPPLLDEHYFYQRGLQHRQSGELEAAVAMYTKALEISPTHFKALFNRAFCEDKLKNYARAIDDYTAALELDPRNPFTYYNLGISYDHTGRHACAVQAFTRAIELDDHHPDFFHNRGFMQRKEGAYAAAIADYTAAIFLDPNHFKSHYNRAYCFAKLGYYDEAVADYTAALKIDSDNSNVYHNRGAALAKLGKLRAAVEDFNRALKRDPKLAFSLNARGLVYDQLQQYDRAVADFTEAIRLDKRNPTWLHNRGHTYRNMGELELAIADYSAAIKMAPHGHTTYSSRAYALRKLGRYEAAIEDYTKALHEQPDVRTKVLNSRAYCFARLNLFEYAIRDYSEVLATDPVDAHALYNRGISFEMCGKYNAAIDDFTRAIRRAPEAPSTANAYYSRGTSRLQLHQVPQAVGDLKQALRLDLMACGLHGEALHSFQAEHPAWCLLQDLGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SKK9</accession>
    <name>A0A088SKK9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_352250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703162.1">
        <property type="nucleotide sequence ID" value="XM_010704860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SKK9"/>
    <dbReference type="GeneID" id="22579254"/>
    <dbReference type="KEGG" id="lpan:LPMP_352250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350028600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_352250"/>
    <dbReference type="eggNOG" id="ENOG502S69H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10033309at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21450">
        <property type="entry name" value="DLC-like_DYNLL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000006">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF60">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="1" id="KW-0243">Dynein</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="1" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="129" mass="14646" checksum="F6997B0DDB00B1DF" modified="2014-11-26" version="1">MADEEDYDVELNKNEANKIERPERLIEILQHDTNRALTGEMAEHAQAVLDFMPAEHTYKDVAVKLKRRLDDTYGGTWHVIVGKHFGANITNDDNTLINMKINGVYFLAMRSGPPDRPHDIAENEAATVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SKW8</accession>
    <name>A0A088SKW8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="3">PPIase</shortName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CYP10</name>
        <name evidence="5" type="ORF">LPMP_353200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703257.1">
        <property type="nucleotide sequence ID" value="XM_010704955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SKW8"/>
    <dbReference type="GeneID" id="22579349"/>
    <dbReference type="KEGG" id="lpan:LPMP_353200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350039700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_353200"/>
    <dbReference type="eggNOG" id="KOG0865">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097014">
        <property type="term" value="C:ciliary plasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000067">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF488">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="4">
        <location>
            <begin position="17"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO02457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="200" mass="21830" checksum="FBB71148D0E9E109" modified="2014-11-26" version="1">MFTRSVISRSTASRHAFMDITIGRQDPQRVSFELFMKKCPVASENFLKLCTGENVLPRVSSIDGIGEPSFRDQFLPQLTYRNTTVHRVCKGYLVQGGDIVSGQGTGQLSIYGEFFDAPEEVKASKFDRMGLLGTAVSAPHLNGSQFFILTADKAPHLNGTCICFGRVVDGWAVVKAIEAIPLTVTGEPVERVVVVDCGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SL33</accession>
    <name>A0A088SL33_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA processing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_353820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703317.1">
        <property type="nucleotide sequence ID" value="XM_010705015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SL33"/>
    <dbReference type="GeneID" id="22579410"/>
    <dbReference type="KEGG" id="lpan:LPMP_353820"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350046200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_353820"/>
    <dbReference type="eggNOG" id="ENOG502RVTN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275196at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002747">
        <property type="entry name" value="Hypothetical_protein_-_conserved"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF17">
        <property type="entry name" value="POLYRIBONUCLEOTIDE 5'-HYDROXYL-KINASE CLP1 P-LOOP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clp1 P-loop" evidence="3">
        <location>
            <begin position="110"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO02517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="452" mass="49435" checksum="D58E887A62C44AEE" modified="2014-11-26" version="1">MPPKKRSSRRLTLNAGEEYTLVGDGAVQITLQSGLLDVAGVMLDTNRPYTFYLHTDRQAVTLFTLEGAACMLSSDNKVDTHRGVARAGKLVQMTRRTILTAKRTKVLVIGRPRSGKTLAAHTLCNLLMRYGNDKKSVFLIDLNAESNCLYAPGCVSCIQVSEAPLWPGLTASPKLLPLSLYTGAAVRPSASNVNSLLHYYDQLNETVMAYTQEVSGAAAVTASQQSASLYASSLNETRSHVVVDAPAPLADLQEGVWYKKLIEVLRPSHVVIVSSREDGEERWSTFLQEDVQRVLPDCEFLFTDPVAHPCERSSSRELMREYFTGTPFYSLGCSKVVVPLKSLMFVEEASEGSGPGSADGVLMRVVHPDASFQALVCALSHAELLEEAPLAPIAGLVTIVYVDEKNEEVAMLIPAAEEPLLRRLIIVPQSRYRDTLRMTNAQVATMEECVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4F3</accession>
    <name>A0AC62A4F3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Beta tubulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3320290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="XUY36737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="443" mass="49744" checksum="1E1DE6A6BC45CBBD" modified="2026-01-28" version="1">MREIVSCQAGQCGNQIGSKFWEVIADEHGVDPTGSYQGDSDLQLERMNVYFDESAGGRYVPRAVLMDLEPGTMDSVRAGPYGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELIDSVLDVCRKEAESCDCLQGFQLSHSLGGGTGSGMGTLLISKLREEYPDRIMMTFSVIPSPRVSDTVVEPYNTTLSVHQLVENSDESMCIDNEALYDICFRTLKLTTPTFGDLNHLVAAVMSGVTCCLRFPGQLNSDLRKLAVNLVPFPRLHFFMMGFAPLTSRGSQQYRGLSVAELTQQMFDAKNMMQAADPRHGRYLTASALFRGRMSTKEVDEQMLNVQNKNSSYFIEWIPNNIKSSICDIPPKGLKMSVTFIGNNTCIQEMFRRVGEQFTGMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATVEEEGEYDEEEEAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4U0</accession>
    <name>A0AC62A4U0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">60S ribosomal protein L5, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3420250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="XUY36789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="305" mass="33978" checksum="53D9B3392DB961EC" modified="2026-01-28" version="1">MPFVKVVKNKAYFKRFQVKYRRRREGKTDYHARRQMVLQDKTKFGSPKYRLVVRTTNKDIIAQIVQAKIAGDEVLMAAYAHELPAFGIEHGLTNYAAAYATGLLLARRTLAKLGIADKFQGAKEADGSYSAVRTKKDDQGDDEARFPFKAILDVGLARTTTGARVFGVLKGAVDGGISVPHRPNRFPGYSKEKSALDAKVHRDRIFGKHVAEYLKQVKEEASSNPDEKCVQFSKYMEAKVAPESIECMYKKAHAAIRADPSKSLPKKAKKEGAKHKSYKTKKMSGAEKRAAAKAKVAAIRERLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4Z0</accession>
    <name>A0AC62A4Z0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucose transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3520340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="XUY36867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="559" mass="60283" checksum="888C26B6B67E74D2" modified="2026-01-28" version="1">MSSKLQANDHPSDSISEKEPARDDLKKSIDDQSDAPPFLSASNAKVILVQAIGASLNGYSIGFVGVYATLFGYSTNCASFNSEQGCVTVPNADCKWFTNTNSTPFCGWTDITCRRTYTYTNLSGMPAAITQCEADPRCRWSYSSQECQNPVGFSSAESGIFAGSMIAGCLIGSMFAGPLASTIGARLSFLLVGLVGVVSSVLYHVSCAENEFWVLIVGRFVIGLFLGVIGVACPVYTDQNAHPKWKRTIGVMFQVFTTLGIFVAAAMGLALGQSISFDQNKDQMVMARMQGLCAFSTLFSLLTILLGIVMSESRAQFGGGEEGAIELDPNEYGYLEMIPRLLMGCVMAGTLQLTGINAVMNYAPTIMGSLGLAPLVGNFVVMLWNFVTTLASIPLSYVFTMRQLFLFGSIFTSCMCLFMCGIPVYPGVSKKLEVKNGVAITGILLFILGFEVCVGPCYYVLTQDMFPASFRPRGASVIQVAQFIFNLIINVCYPIATESISGGPSGNQDKGQAVAFIFFGCLGIICFVIQVFFLHPWDEERDGKKKAAAPAYGKREVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5C3</accession>
    <name>A0AC62A5C3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1420010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="XUY36998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="311" mass="35660" checksum="8FEFC5C1E1B1A305" modified="2026-01-28" version="1">MGLFGKDRVGIFKPTDHTGRNFTWTIYNFSSHAPGTVLDSKNIVCFRNVKFHLHLSLSKAGDIGFYIHFKDPPVPKYSYLFMNVQEETMRQQTAHTIPENSVRCGHWNVCNLNDMKEFLGKDDTLIVIFTFDNDKLTVDKENDDNTITVLWKIPRLCKQYLCPYSSRGFYLNNSLIVVRLDTKCKSSNARAKYNHKDVFAYIIFLFCRKSTIPPHTIELVDADGDPYYTLEKNDGESAPIPLVERHVVDENLSQNGALFVRITFATTTNPLELLNAHNDTGNNDMDEQHDGSNDETVELGEKKEVYNLMEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5F8</accession>
    <name>A0AC62A5F8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histone H3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1620230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="XUY37034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="66" mass="7238" checksum="D87F239EB5F19D1A" modified="2026-01-28" version="1">MPCARCRACRRRGGPALPEQRDPGDPGGVRCVADGCHEPGQHPREACVTVRPKDVQLAVRLRGERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5F9</accession>
    <name>A0AC62A5F9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histone H3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1620120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="XUY37023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="66" mass="7238" checksum="D87F239EB5F19D1A" modified="2026-01-28" version="1">MPCARCRACRRRGGPALPEQRDPGDPGGVRCVADGCHEPGQHPREACVTVRPKDVQLAVRLRGERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5N1</accession>
    <name>A0AC62A5N1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleoside triphosphate hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2220100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="XUY36886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="709" mass="77484" checksum="68DEDC5EF592BBBC" modified="2026-01-28" version="1">MTSMTRISSSVISDNKSHENDFSLFNGETPAQLRQLGPLIHTTVSAFASALEYWSPFAPEWLLLLAPFMVGLVQVVWPTVSAGVSVWRSGVGRRYAFRVLVHEAPLNLYDDVNNLNELMVNAVLMYVCGTLWRQNPVPESQLRGLQMRAVLMDPYRCYKSNDYDSPFRCAYVESDADEGQKLKEETVARLRVAKVPLDAYLPVQVDGIELCYEEESFHRKGSRDPWTRHKLTLRCANSRDAGAKLDAFVQRALEVFAEGAPGKEEDDGARWFFAYGGESDDKVYFNQYVLRSNKGFDTLFFPQRDATLTLVDQFAQRRGRFAVEGFPQRLGFLVYGPPGTGRHAFVKALAAYTGRHVVSVPLSKLRTNQQLYDIFFVREFQSEEGGSVQKLRMEDVIFLFDDVDAANPVVCARDGSRVVQRRAAARLTARAGLRDAPLTTCVIEMDTSSSRPVVRTEDSALPLALLMEIMGGGASKDGGGGSKSEGGSRRRTEKRAAVTAGDAGAGVVGGNLFEINGMLFGENKDRLDLAGLLNVLDGVLDAPGRMVVMITEHPEWLDPALVRPGRFSVRLRLDYMEMEALVQMLGLYYGDVEHSPRGIGAGAGAVGADAGSGVGAARAAQCPAVGAAGRAVHRELSEAQVARVRGAVAALEEEAEAAAAREVDTDGSGERKYCFQVTPCEVEMLCMGQDDLEGFLTQLAGVVRGTGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A642</accession>
    <name>A0AC62A642_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amastin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2021220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="203" mass="21906" checksum="9648C3E3D02AD108" modified="2026-01-28" version="1">MCNIPCRAGIVMYCVLQLIAFLFLLVGTPTGQFRVPNKVAFSGGSCLTVWGLKNKCTSTKWDVRTSNLWAGCPERLKRFHAAEALSVASVVVSALAFLFGVVMLCCCRCLRGLCLVLNILATGCGCAVTALMVDAFYNNHENGPAQYNTSCYALRKNGSVTQPQAIADGDPVVTNYAYGAGFAVYIVGWSLCFINILFLMLPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A687</accession>
    <name>A0AC62A687_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amastin-like surface protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2020490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="211" mass="23929" checksum="1253835B14A1A697" modified="2026-01-28" version="1">MSSVYVDKAAKPEKAGATVIGTTVDRFSFFGLSLAKVKNRMCILAYVIVQFFAFFFVLFGTPIDMFRLRNPVDSDIIVVTTLWGLKAGVFNVEYGLSAAEQWKDCPDRLYRFRLAQAFAIISIFVYGIAFVLGFIMLYCCSFFRWVCVTLNIVGAVTLCLVWTAMVMTYITDEEPFCPEEKRYHTYGSGFVLIVLAWILDLLNIVSLLLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6R7</accession>
    <name>A0AC62A6R7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Calmodulin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0920240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="XUY37341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="149" mass="16825" checksum="5D55062862170230" modified="2026-01-28" version="1">MADQLSNEQISEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDQDGSGTIDFPEFLTLMARKMQDSDSEEEIKEAFRVFDKDGNGFISAAELRHVMTNLGEKLTDEEVDEMIREADVDGDGQINYEEFVKMMMSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RGS9</accession>
    <name>A0A088RGS9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_010360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009370">
        <property type="protein sequence ID" value="AIN95137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696679.1">
        <property type="nucleotide sequence ID" value="XM_010698377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RGS9"/>
    <dbReference type="GeneID" id="22571765"/>
    <dbReference type="KEGG" id="lpan:LPMP_010360"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_010007900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_010360"/>
    <dbReference type="eggNOG" id="ENOG502S8PT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273676at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN95137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="258" mass="28271" checksum="7A35E6BAF68B9E97" modified="2014-11-26" version="1">MNNSAVELQRARRRYKVLLREREALASRGTSDPVVEDEIHKLEANHSGLRPPSSSPLPDHSVATSVPVATSASSEELAKPSSSVARSVSPSTKLHLKTLTLQPRVSKDKLCVGTLVAEQQTHVTPSRVDEQPLAILNGRLVLFFLRLFNESHQKSFLGCWNCVAIAVLSVAVAVLHCTVLDPSSTVGTLITPSLLCYLVHANNLAVLYTQRRQQLSLPMFIVYVCFDAVPSLALDLVVYNLSLTLMGFYGVRPVSFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHZ1</accession>
    <name>A0A088RHZ1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_050760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="AIN95518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703840.1">
        <property type="nucleotide sequence ID" value="XM_010705538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHZ1"/>
    <dbReference type="GeneID" id="22572154"/>
    <dbReference type="KEGG" id="lpan:LPMP_050760"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_050012300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_050760"/>
    <dbReference type="eggNOG" id="ENOG502S3HJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="257140at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="147" mass="16927" checksum="33E5F29992D20E11" modified="2014-11-26" version="1">MLASALRHSAAGGHGSTASTVSKIPSIERASPYLRFSTLRLHPHHEPNFRARPAGWKGWNSKQCMDPWAPYPLTTPVRHVDRQCAGMWFGMGHFALKNFFGPLHWKFWLRLSFLGTIGWIYSLLSYALRMHRNGWEWKNRGAVYSMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIT6</accession>
    <name>A0A088RIT6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable eukaryotic initiation factor 4A</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">ATP-dependent RNA helicase eIF4A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">LPMP_080080</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family. eIF4A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="AIN95818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704140.1">
        <property type="nucleotide sequence ID" value="XM_010705838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIT6"/>
    <dbReference type="GeneID" id="22572470"/>
    <dbReference type="KEGG" id="lpan:LPMP_080080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_080005700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_080080"/>
    <dbReference type="eggNOG" id="KOG0334">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:006127">
        <property type="entry name" value="ATP-dependent DEAD/H RNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 19" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="18">
        <location>
            <begin position="231"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="262"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="476"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="682"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="833"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="231"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AIN95818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="869" mass="94112" checksum="DE54E51C919A2220" modified="2014-11-26" version="1">MPKRVRDADDDLGPSTSESGETDSMKDTVSGTSAMYERLHGPLDDDSSLASSTTTTSSLDPEDSEDDNTSKRLLLYAKVTAGAKAQAAGSMSAAAAAAQSGPAAFLRGLNSSTSTTSASAAAAALNRLKSELLKPVAQPTALTVVNAEDESAHVLTSIVSRKLPPPPAGDAKKLRQLAYVDHSQMHYAPIRTDFYVVPPDMTNLTADEMRALLKELDGAKVHGQNVPRPMRSWDGTGLPDRVLEELEKHGYRCPFAVQSLGSPALMSGRDLLLTAKTGSGKTLCYALPLLRHCADQPRCEKGEGPIGLVLVPTQELAVQVFTLLNELGEAAGLRCVASYGSTSLAENIRHAKTGCEMMVATPGRLLDLLTVNGGKAMSLSRVSFVIVDEADRLFDSGFMEHVEAFLKNIRPNRVTGMISATMPKELRGAVVQHLQNPVVISVGGKPTPASNVEQQFFFVDEEVYDANNIKADMTPRLVKLLALLGEEGGNGQNLILIFTQRKEEVDELLGRLTTLGYANRVATLYSGMDPIDREFALEHFAPGKQFILVATAVAERGLDIPYLGLVINYRLPNHYEAYVHRIGRTGRAGRSGRAVSFFTRGKDDDIAPELVEGLERAEQRVPEELYEVAEKVRALRKSGDARYNSGFFRGYRDAKVQFFTDRNKKEKVREAARAAGLEQFLSSSSSSDSDASSDEDANITAVPVQSRARAASVEEAGANAMALMLHRGALNGALTLSSAQEDRISKALAFAQKTTTAATAAADEMTTVRFQSEYPINDLPDAVRGKLQSGTFMRSVAEMTETSLIRKGVYFDPRYKHSRRMKEGEKPLYLLVVGKSMEAVRAARNKLDEVKAELLSKQKKTVSVTGATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIU1</accession>
    <name>A0A088RIU1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_080130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="AIN95823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704145.1">
        <property type="nucleotide sequence ID" value="XM_010705843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIU1"/>
    <dbReference type="GeneID" id="22572475"/>
    <dbReference type="KEGG" id="lpan:LPMP_080130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_080006200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_080130"/>
    <dbReference type="eggNOG" id="ENOG502SF35">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273729at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="911"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1024"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="531"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="675"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="938"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1043"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1077"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1105"/>
            <end position="1121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1144" mass="120777" checksum="CCD4DD71B9C55C07" modified="2014-11-26" version="1">MLSMFKDKKGFSVLFRGEGGARQSGRVTDTSVCRHSDIQLPGTAARPDGSGVAQHQCQRCSKRFCELESDDDTGVVCRCHRCGYPTCLQCREPATGTPPWVCCVCNGFKSIMWLLEKTRAGPMLVTRIVDYCDPRGQRLMRSMFRFTLQQYQAVTPRPSLKLAGRPSDVPASSGTQSSSRPASQTPPPRLTSGARTSSRLSGERSGARLTQVPPSFSNVRRPLPYTHPKHASLLRSVRRSDSGAAFALDAGAIGGAEGSAKENSPVEEDIVRGSETLRRLEEAVGVVEYSPESKWWASGEVSEEAGGNAELSSSLPDGNERFAQPDDRCAAVADIYHARTPRALACGATLRGDAVEAETLSPHARPSGCAAFQREPLQPQLASTTDPTIQTMCGSAVMRVAVAPAPETSSMRITPLSQPCRLGHSLSPASSVSGRSVSPAPRFPTFGQFLDDHAGFTAAQTHLPRESNVLVTVSPETEEESEESGGVIELGGGRRGDHLVATSGNAKVGLHTPRDTELRTPPSADGGGSSGLRSGRRTSGLCDFTPTRALDMSSARGTLQHRSSSCRRTTRGSLGEMHAPHLYDNSSSKASMAGNPRRSGQVHDSPYAYTLPKQFGSHLKSASSMYGQLRRQQPPLPTRTAGHTLGSDSRQRLGRQNSRTTTPLQRTASHRNELQRTPSRSGALARTNSFFAPLKRTASSHVYAPSFARTNSSTTRALACTPSHRAHRIGAVSGCRGLQRTESAKIAVSGLSHGATARAAQQGTAASQFGYRTPTAAGASSMCSSPLKRTLSSWSPLKRTASHMCLRGGGAAPFGRKQSASCFTRSATTNNGFVGTRSVPALGGGAPLRRTPSAFTRTATGTHLFHYSHGRVYERARYTPGLSPLSPSAAVRGSGYGEPRGYHRVAAASPVRRVPTATRTSTPTMGRRRLPTPAALSRTPTGTRNFERLQSSARREPAGGSGRKAGRTVDPAPTLVGVTRRKALGSSLRHAPSASGADGTAVATPLQPRRFIIASVSTAATAAAVNGGGSHCGPRPVLSSGASIPKSRSSRGSLSSGGAAGPSSHTSSVPTAAAPIEEQKAADVEPRSGRANTQRRRPLGGAIIAKEKEPLRVATLSRRETSGSATTTPRPSIGIAAPRTPFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIX6</accession>
    <name>A0A088RIX6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_080490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="AIN95858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704180.1">
        <property type="nucleotide sequence ID" value="XM_010705878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIX6"/>
    <dbReference type="GeneID" id="22572511"/>
    <dbReference type="KEGG" id="lpan:LPMP_080490"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000015200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_080490"/>
    <dbReference type="eggNOG" id="ENOG502S48X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273155at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="276" mass="29589" checksum="AA66E8F99649B090" modified="2014-11-26" version="1">MAQLTRDEVHTYAKAMIAAIKTPAFQARVRAAMSREPTPADAEAVMERYEEVQADYFTNHYNTEADDVCSGISAGEGNGDTSSAGGTSASTQEASETLAKKVYDMSLGRASDVPTLDGVHIVEQLKSAVCVYKEAETVRLITQLCLLIESQVTVLPATVPALQHLYNNSGHGAPTLQQLQGASAQAGDGHNALPGMNPSPQVRQMMEMAMRTLSPKQRETLERVQRAMLNGSPPSPEDTRDMLLIQRQLGAFMQTIQRFAPTPNGRGRGGGGGQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIZ7</accession>
    <name>A0A088RIZ7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_090410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN95957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704279.1">
        <property type="nucleotide sequence ID" value="XM_010705977.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22572611"/>
    <dbReference type="KEGG" id="lpan:LPMP_090410"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090009100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_090410"/>
    <dbReference type="eggNOG" id="ENOG502S1ID">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267411at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
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        </location>
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            <begin position="119"/>
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        </location>
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        </location>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000063063"/>
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    </evidence>
    <sequence length="1995" mass="208659" checksum="CD39381D65004A92" modified="2014-11-26" version="1">MPTSLPEYHATLQPTVAAGSDSGVLLPYPFDPSASAASTAAELARNSAHCASNTSIAVFLFAKEKLLFRYPDTDPFVVDVAAQGCPSTSCSSAPTGGCAASAAAAAADASNKKAAGDSNASSTPGTAHTSSSRDHHRSRGSHVEQARKGGGGVVGGNTSSGGTCLDPDDASSGQTAALSISGSGGSRLKKSPFIHVTMTMDAKDSHHHHGACPDPNASVSSSSGGVAPQRGMRRPASSYLLGNDHFSGSGGSFGHGQSAVSSGGGGTAAVEGRRGLTARGLPGNTPGTVTQAQQTPPGGMRRPLSGAAAGAAAVSSSTSGPSNARKTNNASAGSAAGGGGVGGSASSGSRNGALQQLAATTGAATCVGIAPNVLMHLLRGALCGTTTINMVNCTFLVFPLLIGAAAPNAVSGQDGRTGSSTGSFASLDRLRLPHRSGTALLVVAMKEPDTDVGAITNFTQCFVNILCREEHRCQYVSTELERMETLTNHWKVGGAAALASAATAPAKKRRPHGEKAHQQQFVAGGAGESFRADASAVTAPSPRLGVQASRGSRPASASVSPASDRRHRALSTTEAPADSASSRGGDTDSSAASSDNYDYLFSPSRPAVRHTRVPAAASDTANEKTNLTSHSDSSAASGTRISLRSGYIEQHHHHHSRESSPSAALQGSISGPFLGWADPDDNAGGDDSAHREDGRDADHVLSHSALPSNGRSGEHSSNRPGDPSQATAASSPLTASASSHSLYQQLAVHVRLAYEVLRVAQCIDVWNRTMRGGCRAGNGAWGGAFEGSVWSKRTSRMTSCGRGATAALRKPCRGQSIAAAYDEQQQLTFPSAGTTLDALPEALLINRMLLLPTSHLTGAERQEEAQSLRSACSRIHPCSVLTIEADQLTEQLQHRYLEVMGWRYSKLVPLSTVYALLQALPSPRRAGSFYRSLELALLEAVQRHHARAAAAAAAADNANTTSVSSRFDVGATATSVAQADLRSSREMTDEGTNAFHASAAEAAATTAAGLDFLAMEIIDFLRVNGAISVASEMYVCFTHSEVTPVALMDAAVARRRRHRLKAERRKRKAAAAAVGALKGSGDSDAARHGKRRHRPHYTAHDLEKGAGIGSNNEMDSGFAVMRPRPQWKTISESASASEGWMSFETMDIGPTTGASSAMPGAVTDPFEAVLDMETAPAMLVLHILERVVDTQQHLHQRQQEEQYHSLAVIGGSERREETAALMESTTGSPKTHNTAAVGSVLDRTPPSSSTDASAVGNTSSHGGYRTDEQDTSLRPWGSGRSTLAAVNATPSPSLHFVASTTAIKSVSPAATRCQSSTSTHPMPTSASRSNVADTGAAATAPQPMSPLTVPGPLSVYCAWGSACPLCELLVAHPQCWTTRSHRGYTLGYYTLNPDRHRRYSSSPAIQLAFPSLDESVCTCARHARHLRDSADFTALMQNSYTGNGSSSLLHSMQPWFMRPRMFITPVTAAYGMSPYEVFERMSYHCNLLSSGSGHRQRLPQHHSSYSPMTRESVTTPTPVLAVNNTSILIEPDPRDPLISRAQAHPHETSMLTTSHDAVVGSAKEQAHTLLQCADIPEAVAEYLRRSADVIKQRLDYARRQLSLLERYEQAWEEQNTAPASTLSFAATATSDAALDAAIATQSASSAAMTVAEPVSSSAIRMPPAHSVGSAASFSGTARGSGGGPLSSSSSSAPVSATVKQLGSCADSLPRSLRYGGRLLPLLTAPRPLSSRALLFDSTTPVAADSGADAPVPQRQQPQGQQQNYTSSTRTNPGMQAIAGASTAIPLDGVGSLLETERSLPVEVLLQYMLHHVIALTWGKRGLEVDTLVRLLEHNLRRLPPLLANLPYILQLRSAGYTSASAVAASASDTTRNEAGAEATAVLSSVFTTVHTRIAAPQPSSAPTFEATLQRSSHCTSPDRSMTSPYSAISHAAASARVTEAEIELLQTYEVLDQLSLMRPLSAYATWPVRTVPTLLLLHTVVNEFSDVLYVDSSMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJI8</accession>
    <name>A0A088RJI8_LEIPA</name>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN96068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_010706088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJI8"/>
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    <dbReference type="KEGG" id="lpan:LPMP_091550"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090020900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_091550"/>
    <dbReference type="eggNOG" id="ENOG502RQGI">
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    </dbReference>
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        <property type="component" value="Chromosome 9"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="33"/>
            <end position="89"/>
        </location>
    </feature>
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        <location>
            <begin position="124"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="249"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="550"/>
            <end position="577"/>
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    </feature>
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        <location>
            <begin position="609"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="663" mass="75086" checksum="D71E0CEF136F01F3" modified="2014-11-26" version="1">MSATPVMGAQVNLALGLDEECSPSETAGKDGHVAHLLAQIAFLHREVERLEKLLCSMRAKSYADVRALTSQYEQTLRQKNAELEDLRHTFGSHGEVVDTGRRCKLLEKQLAAANSEKSVACMEKADLQTKLRKLQSLLKTRKEEVLKAQGTLEESKVERSSTITALKMTVETLTQERERLSSELAEQAKRQRVERRSIGTDCVRQRADAGSETTPLERLTQACQVCTLQGTMTISGEDADPPHSLAALLEEKTRECDQFRGTLEDLSAMQRDALAMLEVTKSQLNTETERRRIAVADVENLSVQLRALQQRCSDQTAAERTMGDKIRLLGEERQKILVEKSHIEREKNHWEEQLRQYEADVTQLSAAKNHTNRQLSALANENENLRAEMQQVCEREAHALYAVKAKDLEVQEILSAYQKSAQENESLLENQRFLERELDNVRAALASKEETVAYLQEQLRSMHLREQQLTLDIQSLEYENENHHQRLARGDHEAAELEAKCAELVQLVHAKEQCMEELHQSLSELSKQVVVKDNESLLLRHRCDALLADNASLRATFANEKAKVEELEASNARLVAREVLSLSEAADRRERSQELADERATVKAVSEENEQITASCERLAEHNKELEARVTSLEKSLQESAEAKERLHRIVLDQNKALSRLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJL9</accession>
    <name>A0A088RJL9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Phospholipid transporting ATPase-like protein, putative</fullName>
        </submittedName>
    </protein>
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        <name evidence="12" type="ORF">LPMP_090890</name>
    </gene>
    <organism evidence="12 13">
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN96005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_010706025.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22572659"/>
    <dbReference type="KEGG" id="lpan:LPMP_090890"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000026300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_090890"/>
    <dbReference type="eggNOG" id="KOG0206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF51">
        <property type="entry name" value="ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="824"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="880"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="2235"/>
            <end position="2257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="2263"/>
            <end position="2286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="2293"/>
            <end position="2315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="2345"/>
            <end position="2367"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="10">
        <location>
            <begin position="65"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="11">
        <location>
            <begin position="2121"/>
            <end position="2372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="169"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="670"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1046"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1233"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1430"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1648"/>
            <end position="1668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1903"/>
            <end position="1928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1940"/>
            <end position="1994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2419"/>
            <end position="2458"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1999"/>
            <end position="2026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1057"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1238"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1255"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1910"/>
            <end position="1922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1940"/>
            <end position="1972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="2433"/>
            <end position="2449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN96005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2458" mass="266183" checksum="A72D54D023C4EDF0" modified="2014-11-26" version="1">MQKAKTALGSFAATVRNTFGCANASGNVIGNDDKTNFMVGTAKDGCSSGSEQSAFVEIDLLRNGLNRQRKFPDNSIRTAKYTLLTSLPLSLLYQFHKISNLYFLLVMIITLVPGASPTNPFSSIVPLCIVLGAGILKDIWEDYKRRKADQKANEVIVYVLRARTELPSNGVTSHGSAATSSSDGGAAEAHRVKDPAKKGKVHGAHNCQQKLLRWWQDVAHVFSRPDSRTGDTMVRRSNRSHDGDGMDVLDEVEMSTDGRGCGTSKAAPTASNLRYAPVQSRGSTTPVAAAEPVVTFHPVRSCDVYPGDVMLFRLGEEVKADCLILNTSLPDGLAYVETSNLDGETNAKTRRAKIQTVEALGTVEDVVEQALGVSASDAAAVQARMSSTATGPPDAWGGSGETTAPTKVYVDCCDALGGGNTARVTDRLMNTSIEETAVTNPRRLNVPLTTTSSAALVKGAEQPVLSAKAAARNGDVMTFPTAIFESIPSLEDLSNSSSPHQHGLQTSVYQPYEEREATEHYLAGAARERSAARLYKHHVRCFSDPQQHFRHFVSPRTGGIPLSRSYAYLGVAESETLHNRADHVTPDITPKRILHQRLMTLNDRLAEEGQLPMPPQLQQLSEQYERTVHSRTNSAGGHLLPLVCTSALHETSSHVWPNDAANRTGESESVFAKDATSHPPHISGELQQKSASDPQPREGAGDGPCSPSCGCSALDRPLVAHDEPLHGSGSATAAAPGSPPASGVVLVSCPPTPDLSIWFGQLRLPTGEMVPLGIDQFIPRGCVIRNTDWVLGAAVYTGCHTKMLLNLRPKPHKITSTTRRLNHLNVFFVILNQVLMLLLCGLAIWSKHRLLRKVPGAKSDHSTWYIQWNLERYSDSFLFWWRYLTNFVLVSYLIPMSLYVTLEFNKAMQMLQIAADKRMAVFDEFTGAIKKARPKTSELNSQLGHVRYIFTDKTGTLTENLMTYVGGIVNGHTHNEMQKPGGIGLALLRRRAAHVPTSVLPSAMDPGGEPSLRHDHHHHINFSLDKEAQTLDADIEDNSVGMQGVSSLTSAEPAADKSSSGANGGSDYNTPAHPLQGVAAMMASHLVVADGDKAATRHRDNQGPAQTIAAISNSVAQGAISYILPRVLSDGGATQPCADDESARAALRHAIQEAHQHTTSSRSVPLFADGALGNGGVGSAAPGADGSGPGGFGCSPGLRNVSEAVLERDPLFCYLRAIALCHSVVCFPVDAGSGGNGREAKQAAKKDNGAPQDTKKRKRRHRHHHNQEGDSAGKRMPKRRRRSSASTVGPVPSAVHHQRSREAAHPESEVVPLSTVLSLTEISGGNFVEIPYAVPAGPGTCEDCELCTAGGANSSRSHNLPAHGHVTCASAAPLMKAASTDGRSHYQHYHHQTSATSMALLHGRTSSASWYQNRYLNRTLHSRNFSAQTINDGTGRGRQLNRGPSSGSASGCLGQAAAPAVVGGSAAASASIGITDLEQFIDRSKIYEGQSLDEIGLVNAARENGFSLFERTTRQMYVKALGRVLCYDIVAELEFTPQRKLMSILLQRRPDLDAEAVTTSLAAGTSAHYHRRAPENAAAGAVTAVGGGKSPKPFADIASRVLPDGGAASQSNKDAQLPRVQTRSPFTSFMATDVPPPLLGQSTALSSRATLPGKAEKQQETEGGNKSTDAAVTRVLLPHNAPLRPPSSGAQHLLHQSSLGEMSLYHDCLGSSTDLGFAATAGVLSSKPGKYLLLVKGADSSMIGIVNMQKRANVRAKDKMQKELDAMSQLGLRTLILGQRYLSEEEVREWLPIFNNAQCAMQDRSEKLHEAYALLERDIDIVGATAVEDKLQEEVPQTLEFCIQASIVVWMLTGDKRETAVTIAQTSGLISIGCADYVCHLDLSDILEEEALMLQQQRYKEQRQLKTNDGSLGEPSPLSESSSDAENALQLSEVSMTTRAYLSASSDTQSPQQQNTCPTQVGSTDRTFSTGSPRYETVGTSAGDRHRGAESSTTVDAAQSFLTRKCTRIEEQLRTAEDKCNEGQEVFNAHVVVIVVDGKTLDFIFEDSDRARRFFLLGSRCRSAVCCRMTPLQKAKVVRMFKRNTNAVVLAIGDGANDVSMIQESSIGVGIMGLEGSQAELASDYALPKFRFLKRLLFVHGRFSVFREAHCVVFSLYKNVIVTVGMVSYQFFVGFSGQTLIDSWLLALFSVFFCSLQPLMIGILDKDVEDELAESLPKLYPPLSREFMYFSFPYIFKWLADGLIEGLLFFFVLMYTVGVQDNLYTYMTAAIEDYGATFFTMLVLVADLRAGTLVTYYMIPFALVIGLGLILLPTIEFLYSSLNDLADSNWFVRVAHELYSTSGKFWLMLFFACGVLILFTMALNMYIQLFAPWQNAGFAMRAARRSHHRIPYTCTKESLKAEYARLLARYEELTKAQQQPKEAAVEGSNAKGTAPTVTTAPAAAAVPTTEKARVTVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJR7</accession>
    <name>A0A088RJR7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoenolpyruvate carboxykinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_110260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696875.1">
        <property type="nucleotide sequence ID" value="XM_010698573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJR7"/>
    <dbReference type="GeneID" id="22572891"/>
    <dbReference type="KEGG" id="lpan:LPMP_110260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190005300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_110260"/>
    <dbReference type="eggNOG" id="ENOG502QTTP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275771at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004611">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017076">
        <property type="term" value="F:purine nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="PEP carboxykinase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN96222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="598" mass="66243" checksum="68C56F68EC9A4B84" modified="2014-11-26" version="1">MQVKMMGLSCLGATAAIIASSSSSPLLQQLRGARYANIQETLKPIPGQTAGQISILNEICCNPDAEEERRKPVFRAEVMPDATTAADDNYLRTMYKWGYDSLTLFKKTNEDPGPWWNANASTLVSNWSQVGDYANAGMWSGVWRYTYGIGEYNLRPYELRGRAWGSRDPKTGAVVIRYGKRSTSKPLQRLCFPHTKEHEQHHRIKNPTNIGVTAISALHGKRILRELQYHLGQGLRFYLVDGVFGSDSPTATPYRIITDNPTHAYFASMAAIRAFNYVARQEVTLVKRLSQSPIDEWGWRRPGVLVYHAPSYDFESPRIVEEFGGPRPKDMGLSHNRFIATEPYSIPMKCAMGGEPSCDALLDSTAMLCGRWGFYADEKGYLTVPGESIISKDGRSLTLVITCTEAEADVLRTSPRLYGSRHHRIADGTVSRAWDVVSMPASAAGAKPLPTDIVEQDLQRVQRSLPTRMNLPHTLSHRHHGRRHVSEYGFKWPHNYTEDAATKAYAGGHLFKAPKSDKLAGHQPRPSRFAMSDVDVVIIGEGTDAAAAIVSALMDRGLLYAEEAPLKDAMATALNAAKSVKVVPRGNAKSVLEKLTHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RK03</accession>
    <name>A0A088RK03_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_100610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696783.1">
        <property type="nucleotide sequence ID" value="XM_010698481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RK03"/>
    <dbReference type="GeneID" id="22572797"/>
    <dbReference type="KEGG" id="lpan:LPMP_100610"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100012600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_100610"/>
    <dbReference type="eggNOG" id="ENOG502SJAH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273838at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="126"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="237"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="375" mass="42111" checksum="B6EDE595E4773CFB" modified="2014-11-26" version="1">MLNHKRMIVPAEHPFLIPRDLISPRATRTVAEDDQRPTDASDVGNCVVAAEGAARHPVHCYGDRPVLLLDCTGALRQRRLRRQRRLELQSRASKLVAARADLLRTKNLWSMRCIRARRRNKDQWLPEPAECNAGGHADRGGGDSTVSAPSDAARGGVPAKHLMSALSVQRKAITREVKEVRRELLTLLQEKRTQAATRDGCVLMLPSPETGEVRLLPGHHYRTVCFVGDELRDVLPSDARDTDTATVQRRQRRAPPLREPASEGTTCALSDEGGAEGEHTLAKETKRPLWAMAELLGYVLYLRQCHRNPDYHSRRGATLGSDSIDYQEVREGRVDYDKIAATISYDMVDDYLALPTCEIAMYREWAIDKFKLLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RK23</accession>
    <name>A0A088RK23_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_110620</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696911.1">
        <property type="nucleotide sequence ID" value="XM_010698609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RK23"/>
    <dbReference type="GeneID" id="22572927"/>
    <dbReference type="KEGG" id="lpan:LPMP_110620"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_110010000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_110620"/>
    <dbReference type="eggNOG" id="ENOG502S6IB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8026949at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="252"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="68"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="423"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="423"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="443"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="466"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN96258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="610" mass="64103" checksum="691C6F8F64B88818" modified="2014-11-26" version="1">MMDLRGAPLSKGISTPSGFVQCSVHNVRRKAECCEMKPVLNADMEVIDYRCVCKPAFTCKSASERQSSDLAGGAVTADARKSARNGESSGSTPLVIDASSTSMTAHSVHHHHQGQLSAAGAADRKAGMGTLFAVSFHAASRSAPDASTFAKTAVVSPKSFPSDREGEAGDNDEGKDDENGEGTRGDGMTISDSDADDVDALDNLPSFTAGAAPATATAAAASLPTAPRGRSRYYDSVQNAGTGGYAPPAKVCWSCGMSGHEKPACPNALCRTCHQKRGPYGLPHRCTPVITPSPFIVCPTPSEWRAATQKTATAVGEPKGMAAVRCVACNEYGHFDCSTVVLPSSYALIASSPPGPAAVPQTATPTCCFCGVRGHTVFGCLQREHVNPDYFERRNQLVADALRCGRGNAAAGVSFNNSGGNLSGSGYSSQQQYQQRSYGSPTGGAQSSFSSLTGYGNNRDGAGGVQRRERGWRDDHGQRGGGNQYSNNRREGGAYHHNSGCVDRDHQRQCYESPSLSRTGGGYASPSLSIPRSRDPFQGGRHGHHEGRSLDKYGGSRHSHSEGEQGGVGSRGHGQRSHYPQQSKHHYHQGSRSGSGYGGDSGHYSGDSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RK52</accession>
    <name>A0A088RK52_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_111040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696951.1">
        <property type="nucleotide sequence ID" value="XM_010698649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RK52"/>
    <dbReference type="GeneID" id="22572969"/>
    <dbReference type="KEGG" id="lpan:LPMP_111040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_110014200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_111040"/>
    <dbReference type="eggNOG" id="ENOG502RZ0U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="278380at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839005" evidence="1">
        <location>
            <begin position="20"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="268" mass="27548" checksum="4C5DB1F7E9830252" modified="2014-11-26" version="1">MSKSIAIIAAGAPAALVQAASAMVSKATCGAVKTTQATSAASNAVVVGMQAPRGVYACVTEPPSTPSEPYAGVKTVVVRAILPRGAPDTMQVRDVLDVYPASGIACEAETAKAVENFTKAAKVAVEKAKAMKASRVTLVVKPATKYERLNALFRETCTKTIEASGLSVEASTTAAAANILTMFPERMSVAMVCDDPVCENVQYAYAGIVGGVHTTYYTDAGSKIHGGHSYKSVAMALAEELKSLGMKAEAAKVEAAAQKSPRNAAAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RK56</accession>
    <name>A0A088RK56_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_120740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009381">
        <property type="protein sequence ID" value="AIN96402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697055.1">
        <property type="nucleotide sequence ID" value="XM_010698753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RK56"/>
    <dbReference type="GeneID" id="22573080"/>
    <dbReference type="KEGG" id="lpan:LPMP_120740"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_120012100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_120740"/>
    <dbReference type="eggNOG" id="ENOG502QV00">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="258902at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36219">
        <property type="entry name" value="WW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36219:SF1">
        <property type="entry name" value="WW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="423"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="439" mass="51058" checksum="0FD8E1D9EA290E76" modified="2014-11-26" version="1">MLRTTSSKYLRATPLLRVWAAEEDDPNAPPTTFKNVKPGRLLRLWRQIRHRAWILYTWDEEWISPIQEGYLHQQRLEQVCFAPLSAYGMVPGSYCDPLLYNTKNTSPFRWHVANVQSDIVGHWYVDADELFRIKDWQPKNPDDPLEMFPRPPQMLLKWDESLDEHGNRTFRYKYCYDMMGPTGKWEAYPRYPFSHLYQGGPDQHGRAEGYGFKQGHLLRCNEEEEEVLRRIMEEEDKEWEMVKRTEVVQEPWSYPGKIRPKDFEGAVERAKARFREQIRYGKETDPSEDPEYDLVQAGEYVEPRDGPRAEWRHLWTSNRKPGESLPFQVTFNDGLRFEDNEGRPPVHPVAHYEETPKEAPYKKYEDADSAAARAAEAAHKAACEKSFEEAMGRHRKLFGDTSGKPRGPTAPLPTGCPPMKDAPCSPLPSDSNPSSKPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RL57</accession>
    <name>A0A088RL57_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_090130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN95929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704251.1">
        <property type="nucleotide sequence ID" value="XM_010705949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RL57"/>
    <dbReference type="GeneID" id="22572583"/>
    <dbReference type="KEGG" id="lpan:LPMP_090130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090006200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_090130"/>
    <dbReference type="eggNOG" id="ENOG502S2KH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272121at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="159" mass="18846" checksum="7B779DFC02F744F3" modified="2014-11-26" version="1">MRSLYRRLLKAGEEGSMMQRCLTVNSLSDSLTYGLRLLRLHRGLTTVDAMAQQTPWWRVGRRARQGLTRRYYAWSLQSLRLQLRSRNAIADVLVYLLFITICFLLYEIYYTCRIGVNRAEERYRTLAIPIIQTLDALEAAQARKRELRKEMENDIVRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMW0</accession>
    <name>A0A088RMW0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_190500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698045.1">
        <property type="nucleotide sequence ID" value="XM_010699743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMW0"/>
    <dbReference type="GeneID" id="22574104"/>
    <dbReference type="KEGG" id="lpan:LPMP_190500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190013300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_190500"/>
    <dbReference type="eggNOG" id="ENOG502RZ1A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="261536at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="569" mass="65429" checksum="28D54A76B7A9D996" modified="2014-11-26" version="1">MSTLFKTNAWERSPPSQQNGAAQPNNITTADVSKASSLALLSGCGRDQGTVQDGTSFTHSADALLAAGNPVAETDVLQAGGASTVQYGLVVTKSNKGGAVVVAHQPATFPGLYKDVDYPVYTVFAPPKPPGDMPPRVKRRARPGPVYKNDISTAGARQHRAQREVSRMWRGVLCRRRLQQARTLDEVLNNRVRRIQCWWRSLQARWRLRQLHAIRKEWAKERMARYITGRVENTKNIIYWQHCRYGYAAVLIQRMVRWYLREKQRRECEAQGVPESEWPPALEHPPTHKHSLYFPWRRPYGTAEACQPAPTAGELVATGENALHNRTLLQFREVRAPVPPPTQEEVEAINANMRERNAQQALALTTPETLSRAEWKTENIHRKDLDFNAAVVQRLYRSKQAIVKVNTKKLTEKYLEKNVRIISRTFRMYVLMKRLRIRRATTESQARARVARRSDEKVEALKVAAVWQRDLMDASAMCIQRCWHWYRFEHQGVVPASYAVMQVVPTPPPYGLIDAHLKREREMRWASMNLMERHELEKQKRQLYLRYVPSRVIVCEHIGRFVAAPLAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RN78</accession>
    <name>A0A088RN78_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_200250</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698224.1">
        <property type="nucleotide sequence ID" value="XM_010699922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RN78"/>
    <dbReference type="GeneID" id="22574232"/>
    <dbReference type="KEGG" id="lpan:LPMP_200250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000028000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_200250"/>
    <dbReference type="eggNOG" id="ENOG502SM5Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272349at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF2">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0736">Signalosome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN97517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="595" mass="65320" checksum="F9C38CEFF3EEC0B2" modified="2014-11-26" version="1">MTVYTMVMPCLQTYARLSASVLASSDKGETQAALSLLLQYFSRQSCNPSEVEALEQWGRKQGNEEWLQECGTDVMEVVKRRVTQRARALSEAVANRQEILMMDARNAGVPAVIRAADVYDRKRSGTATLVQWWHLSDDDPWSFTAAASCSHAARDGYDGYRFICLREALALVGPYLDLMRQAAATGDWDGVSRFFIEAASNIDRVSLRDDPAVIFGSLELSRLHLVLTFASRGGVASVENALQSTRVNDDMRRAAALLDRLGTKERDTAEEHLSHDASAASVSKVQAYWRLTLSYSAFFNTVAAYVDGLLGKFERCAKALLGDGTGTGVSLWGAARYPNIHFLPDSTAHVKHPGAHPGRTKMQSGACSVMSAVFPCSSNHIRATSSDYYLDEFAPLVTRVIAPASSFSTLVVLSAVGTLPLHVALTQLRTCVEFREVYESCGELTSLLDALWRGQLGVAWRCAQEAATRHLTREPHVQASVAKKLLQYVRRSLCFHYLRVRRTTLMADAAVDLGFESSEEIAETATALISGNYIDARIDLVRGAICSNELDNERCEETEGKIEAAALATLNFSALKVQFTCLSAERNLIALRDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNB8</accession>
    <name>A0A088RNB8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_181500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697983.1">
        <property type="nucleotide sequence ID" value="XM_010699681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNB8"/>
    <dbReference type="GeneID" id="22574040"/>
    <dbReference type="KEGG" id="lpan:LPMP_181500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180018300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_181500"/>
    <dbReference type="eggNOG" id="ENOG502SJD5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265657at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="25"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="420" mass="45160" checksum="4AAEB0457C8FFC9C" modified="2014-11-26" version="1">MAALVTSVSPKAGRSSAIDDCDDVVAFVVDDSQHTLYFSKRALMNHTPFFRAYFTEHATASAGESSSNTIVLRYVNPRSAEAALHLCHSANHADDELFLSLLRECEGADAARQPEALLAVLSLYAACVKFELHAHARAASATAARAVTKRTVYDALKTCARYATTLSPETQRAVGLDALLAACHAFVRVPGACQGERRWRRLYAQYPKLAEMVAAASAASAVSAAAHSTSTAHGESSAIASAGNTPSQRRTLLSPRKEQDTIEESAVMIPQSAALLPDVFTGHLRQTEGLALAAQWRCRAMSAEVAALRESWAALESTTRRDEAAATEATLYLGEVRVYLQALRCAEAEVQRLCDAAAATCAAPSLPTSASTLHELRYTLQHASEWAAERKAHIDELLAIEQGAVRELDAELAQLRGFFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNJ3</accession>
    <name>A0A088RNJ3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_150870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697462.1">
        <property type="nucleotide sequence ID" value="XM_010699160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNJ3"/>
    <dbReference type="GeneID" id="22573507"/>
    <dbReference type="KEGG" id="lpan:LPMP_150870"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150013800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_150870"/>
    <dbReference type="eggNOG" id="ENOG502SIBI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268055at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="316" mass="33138" checksum="F5CFB84992FF6BF6" modified="2014-11-26" version="1">MDSHSSSPTMTATTATAAQQESLEEAYVRLCTQLLLHLQRREISAALRMAEVIRDVLLDSPPTAEHSNGSSSGSGVAGSPSGADLFHGSPAEQLLQLRGQLKTLASAESTRARGDDDLDAASESQSTSSETGNGNSTIEASSDDDDVETDETGLASSSEVDDDVEKIEEVMTVGSSSSHGPQQQQQQTAARLLAEVLKAWPKASTKSAGTPPAEASSSVLSLAKSRTSKPGQLQPRPPLPCHKVYGKGKDNASAVEEGRGLTMPGTPSPLPPLLGEGVAGDEEDESLDADAEAVWVRMQAQVATEMNRLAIVRKHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNK9</accession>
    <name>A0A088RNK9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="2">1.11.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_151070</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="2"/>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697482.1">
        <property type="nucleotide sequence ID" value="XM_010699180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNK9"/>
    <dbReference type="GeneID" id="22573527"/>
    <dbReference type="KEGG" id="lpan:LPMP_151070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150015700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_151070"/>
    <dbReference type="eggNOG" id="KOG0852">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="185659at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03015">
        <property type="entry name" value="PRX_Typ2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000003">
        <property type="entry name" value="Peroxiredoxin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF171">
        <property type="entry name" value="PEROXIREDOXIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 9 12" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="6"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="10">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN96829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="199" mass="22475" checksum="696DB9D21DFD1239" modified="2014-11-26" version="1">MSCGNAKMNEPAPAFEETALMPNGAFKKISLASYKGKWVVLFFYPLDFTFVCPTEIIQFSDSIKRFSELDCEVIACSVDSEYAHLQWTLQERKKGGLGPMEIPMLADKTKCICRAYGVLDEKKGVAYRGLFIIDPKGILRQITINDMPVGRNVEEVLRLLEAFQFVEKHGEVCPANWKKGDATMKPERQASIEGYFSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNM3</accession>
    <name>A0A088RNM3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sfi1 spindle body domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_201430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698344.1">
        <property type="nucleotide sequence ID" value="XM_010700042.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22574352"/>
    <dbReference type="KEGG" id="lpan:LPMP_201430"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200019500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201430"/>
    <dbReference type="eggNOG" id="ENOG502S78M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265608at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="994"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1062"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1168"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1066"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1173"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1198"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1237"/>
            <end position="1256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1308" mass="147167" checksum="969BFDE4270FD243" modified="2014-11-26" version="1">MSSCVEESALFSFSTKDLVTAHQGTCTVVYQAVCAEAIRIIFALYELSQSGAAELGDELRHCRTVISECWHSPLDVVDCLTPQSQIRSSPLLSCSPSHEDTRLRPQSQSKEEFRALSSSAEVRGRITNASLYGLLTAAHLLRCSTWTAVSLVPRTWREGHSAGTQVSQLLSQARAAEELRTRESGWCATALVQLTEWMLFSGSPHVPSSVASTLLSRALSVAEVQRTPTDRRDHFLCSTPPLRAADEAPSDPLPLYFPLLLDGKECSRTSVSSPWQPSRVSDAVEGGCVHGWLLDDLPQWCAQVSLEAQSKAWHRTSLLRRALERWRARRGLRVVAHLSHAAASAPEVEPHQSALTAHSFSLVPQVSMLSNAGSRKVVEEALPRRLKLSDASEAVTLSHTTVTQTAADTPRISKVDNRGSGVPPAWSFTEVREFDVSTIEIDTAPPSPSQSQYPPCASLPAAPMLPCADHGDDAASVSKTCRLESVLRGVTTMQSPPSLDMGAGDNTSTLSEECGQSPHRRPREIPLLQRRGDVEDSLASSTPARTLSSKQRFLADANCTSASSGPTALSAHGVFGREAQQEERARFIVRRRESAILHQVFFHWRDRRLYESLATRFIQTQRRETTRAQCWARWRRRRAALLQRDKEVRDVERCDAYTKLKALQYFKRLLQRWKMTVVVRRFCISTLGHRVLRAWGCTTRFVQAQRTLQQKLIGARRVKWQVWTQWQKRRQESVADRHRAEKHGTAVLLLMKEACVRQQALRVATSQCNAVILRRALQRWTLRCTISAQLRSFIASKRPHSSLTRQAWWFWRSRCLERQRRREQEHRLRAFRVAQFARVCFMRWVQRWRRETHIRTCVARQQRRHLLYSLFLQWHQRMQVCMIVRQGQQELALKISEQLQGRRVLRTWRRRATQHAADSQRLREAIMGTDAERLLRLSRLARTFYHWRTYSFVLQRYNVDRRRCLPVTANSTAGMRSIRERGAVLRITGDSRVEHQEEADVGEVDSESTTNPAAMLPLPPPARSAVSKVVPTGRSHLSRPEHASRAPTHYATFAQSSQKSAAHCGSATAMRRSTAAATAARDGSEGTGHSGKNEGGRTTTFTAPQGGFRAVLRRQLSIPLRKRTIALQRQLLAVQLQQRLFFSSASCVQALATSSRSMPPAQPVFAELPYSITPTPGRTTRVRTPPPTRAIDQHWHSNESGSDTESQAPLRSCTATPLFSARKGERAERLRRKAARRQSAALVESPHSSLPLQPHSGTHLRDNNNYVTVRSSSVSATPTQHLLSQMEQLARRIRTLEAGYTTEAATAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNY5</accession>
    <name>A0A088RNY5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_203060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698509.1">
        <property type="nucleotide sequence ID" value="XM_010700207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNY5"/>
    <dbReference type="GeneID" id="22574517"/>
    <dbReference type="KEGG" id="lpan:LPMP_203060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200036500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_203060"/>
    <dbReference type="eggNOG" id="ENOG502SMD5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264200at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="716" mass="76589" checksum="400C16498013E4BE" modified="2014-11-26" version="1">MMLLHTIPLFNNDLRCTHSRGSARQHMANKRMDDSQCISPATDSAETGTSAKAAWIGTHFFSPRLTKTVPPTASSLLEVEKIAWVGLRFLAVKTRQRQLLLVRSGLTERMSSSNSECDDDSQLATLAETHGGQRDANAVCVSFARVADFCTTTTATKRGNVGKESSPVSVMIVAGLQRVTGVVCCCGAAPAANPAQKLAQPQPSQVKEHTWNIGPFNHVASTSLTDSQVYICATSPSGNVEVYTWTVDSAGEDAAPVCVHQVLMALGHSFYGIAVTSAVVPEHETATPATQDVSFWVMGGESAVTHTDRTVLGGDAEAETSTLPALRGLHGRVLQVESQTSQSSGKNQSSNGSHAAAPAFNSAPRTLNSLWAASSSGSPQTTEETIQGATVSSATAPALAATPPTVFEAVSSLRMQEPCFLPSQRRGALQNGVDSAHPRPCCELIRRYALLVRASATRVIVTDRGSPAISASSPGCVNDEQKVSWSSAVLSLDNADSAAALDWLAEASSEAGTPPSFSIASVAPTHVMEAKRQASSTTIQQHMHSLNIFTPHRILQLSVSHQRDSTDDSIKQLRFEVQGTYDVNRPQRIIGIAPLFSPKAPAPLLLFYGLASSIVTNSDGSDEDARSVYGQQTRKSTWAVVADVQASLLHELAPWSSSVKAEVTPKRSIDVQEHHCEAELFGKIQAIVQAEGTRLQRHLDERMNRLEAMLQRLLQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RP06</accession>
    <name>A0A088RP06_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Electron transport chain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_203320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698534.1">
        <property type="nucleotide sequence ID" value="XM_010700232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RP06"/>
    <dbReference type="GeneID" id="22574543"/>
    <dbReference type="KEGG" id="lpan:LPMP_203320"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200039600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_203320"/>
    <dbReference type="eggNOG" id="ENOG502S1SM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275715at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20261">
        <property type="entry name" value="Complex1_LYR_LYRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045294">
        <property type="entry name" value="Complex1_LYR_LYRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040330">
        <property type="entry name" value="LYRM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14273">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14273:SF0">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN97827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="173" mass="19987" checksum="768E3142170B1D0F" modified="2014-11-26" version="1">MFAAKPTIREIRHAAESPYRAQVLSWYRRCLRAAFSVPWSSDEDALYVLEETRRLFHQNRGIREVERIERKLREVEMRYEMALHYNIPYPRPFNKMQGSMQESGVPYAPYLDSAYDHMVNPNIGVNAEGSANLGIMGGLEKSSYYFEDNIGEADVDGRTNPYDTEAEPPSTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPI0</accession>
    <name>A0A088RPI0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acireductone dioxygenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Acireductone dioxygenase (Fe(2+)-requiring)</fullName>
            <shortName evidence="11">ARD'</shortName>
            <shortName evidence="11">Fe-ARD</shortName>
            <ecNumber evidence="11">1.13.11.54</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Acireductone dioxygenase (Ni(2+)-requiring)</fullName>
            <shortName evidence="11">ARD</shortName>
            <shortName evidence="11">Ni-ARD</shortName>
            <ecNumber evidence="11">1.13.11.53</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_205150</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:49016"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.53"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16723"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
        <text evidence="11">Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the acireductone dioxygenase (ARD) family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.54" evidence="11"/>
    <dbReference type="EC" id="1.13.11.53" evidence="11"/>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN98007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698714.1">
        <property type="nucleotide sequence ID" value="XM_010700412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPI0"/>
    <dbReference type="GeneID" id="22574727"/>
    <dbReference type="KEGG" id="lpan:LPMP_205150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200058200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_205150"/>
    <dbReference type="eggNOG" id="KOG2107">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1867259at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00878"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010308">
        <property type="term" value="F:acireductone dioxygenase (Ni2+-requiring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010309">
        <property type="term" value="F:acireductone dioxygenase [iron(II)-requiring] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02232">
        <property type="entry name" value="cupin_ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000099">
        <property type="entry name" value="1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03154">
        <property type="entry name" value="Salvage_MtnD_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004313">
        <property type="entry name" value="ARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027496">
        <property type="entry name" value="ARD_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010357">
        <property type="entry name" value="TXNDC17_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418:SF0">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03079">
        <property type="entry name" value="ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06110">
        <property type="entry name" value="TXD17-like_Trx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 11" id="KW-0408">Iron</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="3 11" id="KW-0533">Nickel</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 11 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="12">
        <location>
            <begin position="219"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIN98007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="344" mass="39252" checksum="827DCDD37F3EB498" modified="2014-11-26" version="1">MTECWYIPEEVADRREENRLSPNVPGSYEALSEAGIFFRHFDPKEVSDDIEGFIQPLLKKLNYHSYDVVNLSPATLGEEKFEALAEQHFMEHTHEDDEVRLILEGQGYFDVRDANDKWIRLLSKPGDCIVLPAGMYHRFTTDHSKCIKTLRIFKEAPRWIALNRGPETEEKPARKEYLARLHAPAETAVGAANSHTIFSLHYPLKLDAELTVITKRLLEQHSKKPLALMIFLTGSTDPTTGASWCPDCIPAKPQVAQRFAELQGKYGEERAIFLQLPVERAGYLGNPEYPYRKHPTLQLASVPTLLVLTPTKDAKETGDVQWYDRLEVKMRTCDIDKADVLCLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPK0</accession>
    <name>A0A088RPK0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GPI transamidase component, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">GPI16</name>
        <name evidence="3" type="ORF">LPMP_202440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698447.1">
        <property type="nucleotide sequence ID" value="XM_010700145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPK0"/>
    <dbReference type="GeneID" id="22574453"/>
    <dbReference type="KEGG" id="lpan:LPMP_202440"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200029700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_202440"/>
    <dbReference type="eggNOG" id="ENOG502QTWF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="278477at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="693"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="395"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="741" mass="79702" checksum="EB5FA9F671E13377" modified="2014-11-26" version="1">MHLLARRRNALGVLLAFIIVVLPWVMAVATVSSSSYAAHTAGRYSMMVEELTGSLDEVGTSPTLVSIAVEMSLTLPAKPGAATAWEGDTKASDIDDVAAEHLTFDEDFDPIWYYVLRRRGFERLDWSGCGGKWRPEWSIPRARQCRDGRSGDTAALSVEKDSTSALFARLRHFLSHHVVCTYSSVSFCGASRERDAASQFQWAAQFVSTLTSSPLSWTTTTPRHSRPNGIVIQNASSHASGSGDAYWCSYHLVYHDTLCTQHVSPLLNGGRSGRGVQEGLPQGIFKAAFPSLSMYFSAPFQHFSVRATQDRLPGNGTVAQPPTVQLKVKIRMSMVVGEASDLEALGDLWSRELPAYARDGRLQVHIGPGGLSQQLRTALSSMAIVSSPREDQAKTTPAAVVSTSASPSSRVGCSPEVQYKVHTHGKDHGYLTVELQPALLLLDPHSGVDVEKCEEADGDNQESALLQSFLLSEGDVVRTLLLFPLHLVRPSLYNMESLLGLTRIVSAHTDVVSNTLAVLLETTVTPVHVAAYEAAYAHARKCHEAASGGGAGARDCRAAGGVLLGRFQLFFGWSALGDMPPDDNSNRLVPQPVVVIHRPGSSVKVDAAEASSKSDFCRVQRRHAALLSAIPQIDHGDSLATVFQLLDGTCAWQDGKRGPLSAMMGALKEGDACAYWVRSTVASGTTIPGPDGAMIFNVPSIGLVFLAVIAGIVTRLTRRWTCKSEDLANLLTAEGATTAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPP8</accession>
    <name>A0A088RPP8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_205760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN98067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698774.1">
        <property type="nucleotide sequence ID" value="XM_010700472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPP8"/>
    <dbReference type="GeneID" id="22574788"/>
    <dbReference type="KEGG" id="lpan:LPMP_205760"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200064900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_205760"/>
    <dbReference type="eggNOG" id="ENOG502RXWK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="261603at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="400" mass="44418" checksum="FCD3F51B1114C339" modified="2014-11-26" version="1">MQLVSDLQQRPKKGRLSVEKNIVPFYDLCTAVQFITFLIHTVTTVIGASRTFVHNIIVQNDFELTPALVHKTRNCSFSTVRNMYAFDSVNMTFTQSSVNDVFVDQAIQMRLAIFVCAATFFVGAVNRTLVDANVFVIKFRNFYFWKDIISATELLLLAYVMQITATIVQPASLLRDYLRHCGVQASSYLPFISIINLWVFAGVGYLTYVVGIALYLNNTLPKYGVMTPQEIEEYKAWLRSRRTEQEQVRMLIDEAKKAHARLHLMNSTDYKQGESNALSLPPSIMGPNGPTYSYPYSAAFPDYAPPAPGIPSAITDPRLPAPQLFGAGMIQTSGQPGMMPSSLYNSGEPPAAGPSFYETMPPGTTAHVSSAPRDPMSLPINMPRRRTAPSPSQGNPPTYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQ81</accession>
    <name>A0A088RQ81_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_211540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698939.1">
        <property type="nucleotide sequence ID" value="XM_010700637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQ81"/>
    <dbReference type="GeneID" id="22574976"/>
    <dbReference type="KEGG" id="lpan:LPMP_211540"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210019900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_211540"/>
    <dbReference type="eggNOG" id="ENOG502SGMB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272595at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="162" mass="17916" checksum="76193DB3568A3C78" modified="2014-11-26" version="1">MHLPGRASSLRRQPSFGGHPARPHSALSSFPLLMLIIMLGGGIVGPSFAVVHAKDCLTRGSNAMIAWKHEGGTFQCDNCLRADAVSVSSNTIPRHWTEYDKDRHAMNFFVEEHRDGNNVLVRDEIRGISILLRSDLSGIRTEGEQNFRQLYSGAFIPVVDCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQC7</accession>
    <name>A0A088RQC7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_205740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN98065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698772.1">
        <property type="nucleotide sequence ID" value="XM_010700470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQC7"/>
    <dbReference type="GeneID" id="22574786"/>
    <dbReference type="KEGG" id="lpan:LPMP_205740"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200064700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_205740"/>
    <dbReference type="eggNOG" id="KOG1309">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1898560at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06466">
        <property type="entry name" value="p23_CS_SGT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000081">
        <property type="entry name" value="Phosphatase-like protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007699">
        <property type="entry name" value="SGS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044563">
        <property type="entry name" value="Sgt1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45862">
        <property type="entry name" value="PROTEIN SGT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05002">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51048">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="2">
        <location>
            <begin position="7"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="SGS" evidence="1">
        <location>
            <begin position="118"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="213" mass="23637" checksum="DA8EA8F0EFB75CEC" modified="2014-11-26" version="1">MPTVPFTGQVQMEWYQSVEQIHFIFYVKNRTNDDVAVTKTATSLEVTIRLDDNGREYSCSYDPLFAELTDDPPSISARPMKVEVSLTKAQPYQWPTLERKADAEGAVVAPISDAPSGALPATAKDLRYPNSKGKDWSALKLEVEEDAKPEGEAALNKLFQQIYGDGSDEQRRAMIKSFTESGGTVLSTNWEDVKKKKVEAQPPKGMEAKTVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQH7</accession>
    <name>A0A088RQH7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pseudouridine synthase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_200020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698201.1">
        <property type="nucleotide sequence ID" value="XM_010699899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQH7"/>
    <dbReference type="GeneID" id="22574209"/>
    <dbReference type="KEGG" id="lpan:LPMP_200020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200006800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_200020"/>
    <dbReference type="eggNOG" id="KOG2553">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10256309at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02568">
        <property type="entry name" value="PseudoU_synth_PUS1_PUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.660:FF:000035">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041708">
        <property type="entry name" value="PUS1/PUS2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF9">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="7">
        <location>
            <begin position="542"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="250"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="300"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="343"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN97494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="698" mass="78230" checksum="26125E059EF2B56B" modified="2014-11-26" version="1">MSSPCADGVMPAPAEEAKMSEQPAPKAPPLEPIIPGCTPYKYYRVPEGLKRKRRKQKVGIIFGYVGECYCGLQWNHLPEYPTVEEALMKALFETDMISEVNFANFKVQQLLNFERASRTDKGVHALRNVVSVAVMLPYDPAYAKRRLAAMQEHTKGTAAGETHNVDGDSEEDANDAIFSCEEAKRLLNKALPRDLHVYGVVPVTRSFNAYLNCGGRRYEYYLPTFSLMTEEEYSKTYFPTSLAPSQPTLKEVGFVPGKHGKPSAPRAALATEEEEEAQRRKHKNSGRKNKGHFPKRKTAKAAARTVETAEAGTAPPDSTPTLEGEGGDSVPETVAPRHAELLDSSSETAADSTNPIARNDGAARECDSDTESQGSDVEVQAALERVSKRRPYEDNYVTHFHDGLFESMILFRTIPTDAMRHIARYRLAAEQLQHIRRLFHEYEGTHCYHNFTPGGRSYDASCYRFIRGVSVSDPFIVSPEEALLQDSIDCWSLNHFYSPDERVTATYAEWMTEGETTELQNTITFALEQGKLHVPKSVDTALQERMRQHIRDVYAGGIEVVRIELDGQSFMLNQIRKMIGAVVCIAAAGLPLNHIRDVLLRKGVRRGIPMVPANGLFLSYLDFSGYNRRLKRIQSDGNNGSGKATLDVEAGVDAEEVESQRRRIIAVVLRNEMAEDIMGKWMRSLRHVLRLAWKHTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQP8</accession>
    <name>A0A088RQP8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_212160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699000.1">
        <property type="nucleotide sequence ID" value="XM_010700698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQP8"/>
    <dbReference type="GeneID" id="22575038"/>
    <dbReference type="KEGG" id="lpan:LPMP_212160"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210025300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_212160"/>
    <dbReference type="eggNOG" id="ENOG502S9SG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266525at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="445"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="593"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="684" mass="76851" checksum="2E63317C28853AA7" modified="2014-11-26" version="1">MKKRDGLYVTRARMTNPTALYDRGIKELQRISAKREAMRAKLEEAELAEATFHPSISPRVSALKRSGDIAGVDRDSSAQLRYRLHLLELPDGLADASHRYTPRLSHTSEMIVRACRERGGAELPPEERLYRDYFYRQQTIDEARLVTPPPTVVRSKRDIDVHIAELYAFEEQRQHAITAAREALLSASAGVHPRVYVDPRALVERLTKNRSLSQRRTAAAQLEKDQWPFQPQTSANARMLAHQARLRGLHRWVRYFCGSDILSLPVLSTFQGQAAHEAARLYALLWQHSPAKTEWSAKELAEAFLDGVKDNPFVAELWRRRPPVGEASVTLSELTYRPCLNPKSAIIVEKMEAEHRCGPAHDRLFLDARAKQLSQRQQELEEEQAELESKQREQQRRQRRQAAWHAQEAHRLEVYLAEKAKESCKNATAEATAAHERPHPRTATSSRRLFLPSSSPQRHRGDSASKLSSSSPRPSPVTETNTVILVPRSPTPSMLGTPSAPPSEVARMRSNKTGGPTKATNSGGHSSASHPRYPSPLFQPTTTSVQAVPSPPRSASNILLSVETWPEAEKHKLDRAAEALRDLLTDPTRPCGASQQASAASSQRSPPAATRIPPCDMKLPHNSRDKLPARTLDVVLECARLRDPRTLPSGERERLDRAQKRQLRELGRLLYSRYKSNIYSTNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQS1</accession>
    <name>A0A088RQS1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_211110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698897.1">
        <property type="nucleotide sequence ID" value="XM_010700595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQS1"/>
    <dbReference type="GeneID" id="22574933"/>
    <dbReference type="KEGG" id="lpan:LPMP_211110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210015000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_211110"/>
    <dbReference type="eggNOG" id="ENOG502SHUI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266585at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="422" mass="45053" checksum="365F26189254B04C" modified="2014-11-26" version="1">MPRLSRVSALSARRRCTSAFQETWLAPTARFHRQWHSTAASSPRAGAAATPAARHADPCPAAAPCSTQVLSSHSCPTAAVLVDTSDSAHVTLPYCLADVQERVRAQLRLLLLQRLLAPLVTESLMDLFGEQPREGSSDIHAGGSGDAAALASTVVHSVTQSPSTLRYLAFSHKNPRLRHPSWAPLWAASPQSNTPSTSSCTPSMELNVDIHADAKRPDEAAVDAFDVRVTLVEQDAAETLVRPCLGEVAPLLGSHMCGSFRAVTTAAHSAMSTTLSSSTTAAEVLSAKPAAPSPLPPPSFTAVTYWECCRVDSYLPSYVQVQAAVRHLLLRRRPTADFTANARSAVPTAFVSVPQLPPARPLALVAVVAPDHLTALYSEFVDMLEREGRQRLHQPQGGATCGGPVHLLLFNSKELVRKNVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQY3</accession>
    <name>A0A088RQY3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_230720</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699229.1">
        <property type="nucleotide sequence ID" value="XM_010700927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQY3"/>
    <dbReference type="GeneID" id="22575276"/>
    <dbReference type="KEGG" id="lpan:LPMP_230720"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230014400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_230720"/>
    <dbReference type="eggNOG" id="KOG0245">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000134">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115:SF601">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="KINESIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="7">
        <location>
            <begin position="47"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="471"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="153"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN98522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="720" mass="82390" checksum="794EEE5E72EC0AD7" modified="2014-11-26" version="1">MTPRRNTPKKRGSVSQSHFQDPNHHLTLADAAEGTEAFKNRVSEITSFRVVSRVRPFIKEELAEMEGQERRSIVEMAGTKTILLDPKDNWAPKAQFEFDASLWSIPPTHRIVHTFQDTKHKTYATQKDVYNLIAKDLVPHVFNGFNSCILTYGQTGSGKTYTMMGLYDPNASCGGDGEEGIIPRVSNDIFVILKERIEEEARTRSPQSVTKFRVEVTFVEIYMERVRDLLDPTLRHTRGNERLQDARIRQDPYSGPFVEGVTKYEVSNWGQCCILLERGSQHRTTCATAVHNQSSRSHAIFQLTVIQEVVVPNDNKYALPTFKTQAGRINLVDLAGSERGGFQDYVKESAAINTSLLALRRVIDNLTERQNMLMEMAEAEITGKRYQERPLPQVPFRDSVLTWLLSDSIGGNARTTMVATLSPLVKNYVDTLATLQWSSRARNLVTLVKMNDQAVVQNGMAFHAGALDKALRIQRQNLDSLRETLRAKQEAARQLARQTKALKTSLNKAHSRELAIKKDRAALIIQRTFHRFMFYKKLEAYELQFAKLRSAEKNDTTDNTGLQRIQKVAEVREQAAKEELKAVEALTDEKAAAVAKYEMDYNKRAARRREAEDRRAQILEAININEVLRQYGEKRLQEVAALRRLADIEREERELSAQKLADMERVIAVSKTIEHKLMVVEDQVRLETLREKHEQARSARYEALRTLQSLRERHRKVTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQY7</accession>
    <name>A0A088RQY7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Membrane transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_220950</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699095.1">
        <property type="nucleotide sequence ID" value="XM_010700793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQY7"/>
    <dbReference type="GeneID" id="22575141"/>
    <dbReference type="KEGG" id="lpan:LPMP_220950"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220012900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_220950"/>
    <dbReference type="eggNOG" id="KOG1330">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF9">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="472"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="23"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="210"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="601"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="682"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="765"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="641"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="652"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN98388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="854" mass="90066" checksum="5E83CFBFCD9BD741" modified="2014-11-26" version="1">MTSSTNRLLDPDTPVDQGTVYCNLWLFIWLKTIGSFDSGAFSAALGAPNGISETWDLSTKLQGTLISSVFLGNVLGCPLAGHLFSRYDEKRVLCAALIVHTVFTFLYAALPIYGVALLNRFFIGISLSFIVVYTPVWVDEFAPKNRQSVWMASHNAGVPLGIMLGYLLAAGPPAFTSSISWCWSFYIKCVLMVPTVAYVARLDARSINTHKAGGSGGDRKGDDDGDDDHFGGPSALSEETSNGVAGTMAFSPPPITASARGSASAGAPRPAKWEKSISQTLRMLEDRALATIRNLYYSMTPLFSNVVYMCSVVSLTSLYFVATGLQNFVTQYLREPPFNASMAIITVGFGSAVVLAPVCGVIAGGILLDRIGGYKRNLYRVTFFTLAWGVCAVFFSVICIFVHTTRGFLLVMSVVLFCGGAIIPPGAGLTMATLPDHLRSTGAAFSQVIYNLFGNFSGPLVCGWVADVTGSLRYGIVTLLLSSVLGVVPLIGIFHVAFYGGGSGIGSAASALIDSGGDHDGAGGAAELVDGNDEVLEVPSSGAVVEEDAGTAARLDGHSYNRDGAKMRAGLIATQEGSFTVPPTTASVRSGASRLAQELQIESPLQRSRQPTLEDGVPSDSGTGTARSKEGAASLSFSMLMRSARSPSAPAAAPPPPPVMPPTHSTSLTAAAVRTFNMLGPLRGPGTARPVTAEFSSSPTKGATELPPTFSLNYAERRCEQQKAEVELMNLEAKAAKVASLPNQRAFGIDLVRGWMNNEVQEANLRPHPSSSSLVRGSSEAGVTHSPHMEPPLAYIASSSVASLEGASAAATTLPQRRGCTLPQRYGNSVEHVTDEAGVRQIHTRTHAGGRMHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRB5</accession>
    <name>A0A088RRB5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MYCBP-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_230730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699230.1">
        <property type="nucleotide sequence ID" value="XM_010700928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRB5"/>
    <dbReference type="GeneID" id="22575277"/>
    <dbReference type="KEGG" id="lpan:LPMP_230730"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230014500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_230730"/>
    <dbReference type="eggNOG" id="ENOG502S07E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273750at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032707">
        <property type="entry name" value="MYCBPAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48421">
        <property type="entry name" value="MYCBP-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48421:SF1">
        <property type="entry name" value="MYCBP-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14646">
        <property type="entry name" value="MYCBPAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="918"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="926"/>
            <end position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1092" mass="117297" checksum="980167DF966900C7" modified="2014-11-26" version="1">MKTRAGMVCRGPADAGHATTDLYDERHRQTKALARWERQKAAWMRMQTHLATTTGSSSTTGKGDNRKLSSTAATSHRSAASGSAGASPARNFTGATPAARAKREDFGILAVAQPEVIKDGSHAWEGLLRCTDTRSARRLVPIGRTSFPYQLYSEARDPTTLPEDHMIYTRVVSEGDVTAGQDTTVESHRFVDSTMQRVEQRAAAQSRVRAALTAATPDDSEIGTGSKGTYVAGQHEKGSGGVFYYEARLRHVAPYVQERLGHFLQPRAFLHVDGHPAPCASAEELEAQKHEWTAAGPSSAPPVEYYPPPPQTQLWASIPTSAAPSRLASTVKPADSMRQRKGLSTVAASRAHSHGASTPATLKNHGCRADGEDALAEEGDREMEDLLSGSVATATPSELPYDSSVGLIDSSVREKCSRTMYAAPTSPLHPLQVNKHGISLRHQQSYTAVSEDLEEVMQTSGPVMELSTRSLLFQTCPHELVQGTVTLHNTGTTTIYFSWVPVDSVEERLGQLERDSRDAAADIEEAESGEEGEEDKCKRRRQLQSDRDGTAATRITHSLAAHQRTARDSFFFLSSPMSGVVLPDEEGIFAFSVRANRVGLFQHTYELLTVPPAPERIFVRLRALVQNDGPSLEWLAAPVAEAIEAKVVLDAQRRLVQRISVDVDAIEGSALSAHIKALDGAAEAATAAERIRRRAQEEAWNLANRFTFDHIPYTAAVYDKLERLYTVVQDTCRTLGRQKNAEADEASQEPAVAVAAPSLNARVKPSGLYASLPAPVSPPKQEPAAPTTDIVETVSVSGQWDGSLLILLQLMMAVRDAPTRQTFFAAFLVLLRAARASQQCSSRSGSIECLDQETLPLPALLVRAATLLADSVQSRRAAMLERECENMLGQKLATAATPFMQAFAAASGAFAFRGAATTRDTGGASPSGSTAHRPQSVHSKKRATLTCGRSGTAAAGDHVGGAAATDVLAPAATKVTTAQRMVLDSISEEELLHFSAIQAPPKSVAALERAEKVALHAQRSLALAAERSAWIELYTALFLEAVDAACDRGPLSACAAARLAELEDIQTSSLLPIDLSTDPIIPLTTGKGGKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRH5</accession>
    <name>A0A088RRH5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_230540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699212.1">
        <property type="nucleotide sequence ID" value="XM_010700910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRH5"/>
    <dbReference type="GeneID" id="22575258"/>
    <dbReference type="KEGG" id="lpan:LPMP_230540"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230011000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_230540"/>
    <dbReference type="eggNOG" id="ENOG502SD3T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273131at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="21140" checksum="D0C5F03B3E00049F" modified="2014-11-26" version="1">MVGRSLRTPPAAVSGAKGDEILQHTTAKFVYAAGAIVAELALLKLVYHEPYRNQRKNRANRFFATAAGFILSVLLTALPNDLIDTSLVGIFYFQLSSQVYTPAIVCGQLLRVYLAALVPALPPLSAAYTAFLAYWADGFAGGFSATQVREAWAEVILTLVVICAFVFSMSARRGASVAPSLLPLEPESDGDDYYVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRQ6</accession>
    <name>A0A088RRQ6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_204250</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Sodium-phosphate symporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698626.1">
        <property type="nucleotide sequence ID" value="XM_010700324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRQ6"/>
    <dbReference type="GeneID" id="22574636"/>
    <dbReference type="KEGG" id="lpan:LPMP_204250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200048600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_204250"/>
    <dbReference type="eggNOG" id="KOG2493">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="260807at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF96">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="515"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN97919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="542" mass="58218" checksum="0A38104C88D3E84A" modified="2014-11-26" version="1">MARPFFWIVVVGAFVSFLTGAGVGMNDLSNAFGTTYGAKVLTLSQIVLLASVCEFVGAVSLGSAVTATISGGIAKPADFEDHPYIFMYGMLCACGAAFCWLVIATWLTLPVSSTHSICGGVIGFALVYGGVDSVSWADNQDEFPFVKGVVPIIASWFISPLFTGVVAAVIFGSVRWFVLRHANSVQRAILTLPIIVAITFFLESFFVLFKGAQGRLHWDVDHAAWVAMWIATVSGGLSCGFVPLLKWRVERMEHRVEVLVQQHVSTPDNVENEMELHRCVDELPTDRGWTEQREAVEPACAAPVSSPLPSWPPASSCAPAQSRCSDDNYDKTETAPGAVLRKDAGIEDNATLSLRELHTVTASGLEVQLYNTQAEMVYRYLQVFTAICASFAHGASDVSNAVGPLAAINSVYQTRSIQATSLIPVWVLCLGGAGLVIGLSTFGVRLMRLLGEQITVITPSRGFSAELSAALVVSFASCYGIPVSSTHCITGAVIGISMMDVGVLNVRWMMVLKMYGGWVFTMVFTALMSAIFFAQGINAPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRS1</accession>
    <name>A0A088RRS1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_204460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698646.1">
        <property type="nucleotide sequence ID" value="XM_010700344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRS1"/>
    <dbReference type="GeneID" id="22574657"/>
    <dbReference type="KEGG" id="lpan:LPMP_204460"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200051300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_204460"/>
    <dbReference type="eggNOG" id="ENOG502S19G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277814at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21203">
        <property type="entry name" value="ECM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839038" description="Transmembrane protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="28845" checksum="5AE33D14F1722F3B" modified="2014-11-26" version="1">MVSLWKTVSLLLTVLALVFSIVAHATSQSYVLERRIGSDGEWAKVGSFAISHLSSQTPARISTQLAGEVSLSREERSSFAAADLVYYRAYPYQEGKPVPKCAPTVVVTPCSLIRGFDAIDSKTVVLHENIKIVPGPNTSLIGLQVSSETNFFHSKMQKGDECDRSVVQKLFPTVHLNTKVGLVQPLKVARKVRYEDLRALVEAENAANTKGKPKTEKRQVSNAEGDATEVEVPVDDRSFLQKYWMYFVIPIAMSVLQNMKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRZ7</accession>
    <name>A0A088RRZ7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_205220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN98014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698721.1">
        <property type="nucleotide sequence ID" value="XM_010700419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRZ7"/>
    <dbReference type="GeneID" id="22574734"/>
    <dbReference type="KEGG" id="lpan:LPMP_205220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200058900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_205220"/>
    <dbReference type="eggNOG" id="ENOG502SMR6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266914at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="718"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="953"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="446"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="573"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="774"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="790"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1029" mass="109709" checksum="DBAA54259DEDF549" modified="2014-11-26" version="1">MNKAFELLRRSASKVEANRKDRKQKGDRNGRGRHPRSPRTTSSPLKSTHQHINRDSGSSRGEKKWRQKLAESKILKRLMQPVYSDDDTGDNCHTRDDMVSNGDAHRLGEIPARSKYLLPDQKSHFANHPTYLPLAEQCRPLQPSSLTSLTPRQGCHQKPGQSSGDNNDGEVGGHTYGAMGEEVGVDDDNYAEAQQTHQERHHGIGHVGSLYEGAVKSIQGNPHRILTASIGSSVSGASSVGPTGLALMPQFRWVPKQGGGGLGFNPFMNFRYQPQQECIASMLPTPWMNTPTPLSDAQQPDDETPELLHGVASPEHEQQQNEGQLHVSGRHNSYSMFYALPSPPPAPQSVPSTRPHCETGTLSFYGPIGSIGIEASCKRRAVEQQSGTDGAAEKAYKERSSRRPAEREETSIQLLTQLWCDVNLLRDARIVDSPGLSCNDDENDDSASGTSSSTSNIESNNDNREFDEAAMAAREKVRQRRQQYSARSPSFYFKDGDLAALRVEDNAEDSTLAPAPRATAVHKPVAVSAQHQQRSVPSTVKATSPAALTGGRRAVGGVAKTSVRRLAAHEVASSSSSSGSSDNDSGGDDSNSDECNTGERSSGFGSDDDNESVDSGDAVSPHRNDNDAHGNLTHLHSWKKRSSIHASTGMSRSVLEYGQYDFMNSFTMNESFVSHMPDGGGGARINLLYVPDDYNDGGEAAAVGDLVLNYTPRHVSTKSAETSVKMKPHPPLSPSIPSQSQERHGSPSMSVARGSAVGPSGNGAAVTPRRGQRRVNNATDIRSATVQNTSHHGGSTSSSSHHHDGGGCGLGEQLAYGSSFGLGSRHNSYLATPCDEAHDAASVSLSVYGVVSGNPNTISSGTSMMDGDGEAFITRGVYRDSRDQTVTPATFGVVSRGPAAPLTVGCGSAVKTCNAASQQLTLPLIDRGSVSPATYSRPPSAAQRLRVPVTPTSPQRLARGTKTVYPGGYLPPITPPVTPTAKKTPAQRNKNAVSTSSFRDLANASITPGLGDIVGGKSYTSLAYELPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSF3</accession>
    <name>A0A088RSF3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PCIF1 WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_241980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699537.1">
        <property type="nucleotide sequence ID" value="XM_010701235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSF3"/>
    <dbReference type="GeneID" id="22575607"/>
    <dbReference type="KEGG" id="lpan:LPMP_241980"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240027100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_241980"/>
    <dbReference type="eggNOG" id="ENOG502QW1U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="193787at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016422">
        <property type="term" value="F:mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099122">
        <property type="term" value="F:RNA polymerase II C-terminal domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039881">
        <property type="entry name" value="PCIF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022035">
        <property type="entry name" value="PCIF1_WW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21727:SF1">
        <property type="entry name" value="PCIF1 WW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21727">
        <property type="entry name" value="PHOSPHORYLATED CTD INTERACTING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12237">
        <property type="entry name" value="PCIF1_WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="PCIF1 WW" evidence="2">
        <location>
            <begin position="279"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="588" mass="64572" checksum="AAD7C48D854202D6" modified="2014-11-26" version="1">MKRDSNGDTADAHHPALAFHREVLIIQQWTKIRRDFLQALEAVAASGVVQWREPRKLWRHAQEALGKWILSQVARVHLPAPDALHDGRSQCTSSVARLLEAEIRFFPSADQLRRVMVNTRGEHVPCAAATGSSPMEGRQELRTYDEQLVRDLSLKSNGTHDPAAVAALVQLVKDFFLAKRCVAAAEAIEAGMQGVTPTQALKPRIRRLEATDPQRTPQQQRIAGPIAEVSVQWPRHWRREQCRDCPPVSLPWAAMEKLRMCYDFFSEASEQAHYPTTVLSADARQHRFHLRAATVILRYEGGLATGSLQLCADTRLKQHLHAAGYHVMDLCASPINAYMKVPQPGRFKGAASDTDDAGAKEVPNHFCSAFYDTDQYFGSIGSAVAVDPQRIYADAVINPEGRPLLLTLDVPYDEDLCELLFQKLVRDMRSATAGGGAVAAAVVDYVLVLPLWWDIHMKIEKRLFGGTGAAKGLSSSSSADPLHIAQLVQERAAMLREGHTVPYSWPEALAAAAGDARTATAAASGAWVCFDGLFIDDDYGYFCAATNKWLHGVTATEVIGLAQPRASPPLKMALDSFYTVPTVSPPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSK1</accession>
    <name>A0A088RSK1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Methionine aminopeptidase 2</fullName>
            <shortName evidence="9">MAP 2</shortName>
            <shortName evidence="9">MetAP 2</shortName>
            <ecNumber evidence="9">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_210940</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9 10">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="9"/>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698881.1">
        <property type="nucleotide sequence ID" value="XM_010700579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSK1"/>
    <dbReference type="GeneID" id="22574916"/>
    <dbReference type="KEGG" id="lpan:LPMP_210940"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210013400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_210940"/>
    <dbReference type="eggNOG" id="KOG2775">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7848262at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01088">
        <property type="entry name" value="MetAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000370">
        <property type="entry name" value="Methionine aminopeptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03175">
        <property type="entry name" value="MetAP_2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050247">
        <property type="entry name" value="Met_Aminopeptidase_Type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018349">
        <property type="entry name" value="Pept_M24A_MAP2_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777:SF2">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01202">
        <property type="entry name" value="MAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="12">
        <location>
            <begin position="154"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIN98174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="465" mass="51781" checksum="70F0FDC593BD5EB6" modified="2014-11-26" version="1">MPPKNASKNKQQPKQQGGNRKGKGSNDDTEDFDAMLAAAVSATMANTAKNHSNNNQAKRNSGGNGATPANRCLAADEPVVPSSADHPENPYPKTESTYPRQTWPEPTVPVSKQFPAYRFPTGEIVDHPGEMNNFRRSSEEKRALARANEQQLQEMREAAEVHRQVRTWAQSWIKPDLSLMLMTDRIEKKLNELIGKDGIVRGQAFPTGCSLNHVAAHYTPNTGDEKVVVTYNDVMKVDFGTHINGRIIDCAWTVAFNPMFDPLLQAVKEATYEGIKQAGIDVRLGDIGAAIEEVMESHEVEINGKVYQVKSIRNLSGHNIAPYIIHSGKSVPIVKGGEQTKMEEGEVFAIETFGSTGRGFVNEDLECSHYMMQPGAEVMQLRSEKAQQLLKHIHKSYSTLAFCRKWLDRDGFDRHLMNLNRLVDEGAVRKYPPLVDVKGSYTAQFEHTIYLGPTAKEILSKGNDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSN8</accession>
    <name>A0A088RSN8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ubiquitin protein ligase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_211510</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698936.1">
        <property type="nucleotide sequence ID" value="XM_010700634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSN8"/>
    <dbReference type="GeneID" id="22574973"/>
    <dbReference type="KEGG" id="lpan:LPMP_211510"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210019600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_211510"/>
    <dbReference type="eggNOG" id="ENOG502SHW1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969:SF69">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969">
        <property type="entry name" value="RING ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="168"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN98229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="278" mass="28970" checksum="BA43CDC70A1038C3" modified="2014-11-26" version="1">MLPSSFSSPTAGSGDNTDDATNTHMHVHTVVINLGDADRIAAGANVGMVNVLSAVPATVSAVMTAAMDLSDLPGLVDLVSDTTPANNAAREWNARSCSPFAPEEVISTFDIVQPPPPSPLTAIAFTSGGGTEWADTAASASPPLSAPEVKECAICLEPLFRMSVRRVAPGNGENLPNSAPYRSNLSAADREAPAAPSQAPPSHPPTPSLPLSVAPPDAAASSDATQPPARDIVAEAAMDVKTVREVYCGHRFHEPCILRWITLGHYLCPLCRSPFVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUA2</accession>
    <name>A0A088RUA2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">vitamin-K-epoxide reductase (warfarin-sensitive)</fullName>
            <ecNumber evidence="3">1.17.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LPMP_272190</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VKOR family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.4" evidence="3"/>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700305.1">
        <property type="nucleotide sequence ID" value="XM_010702003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUA2"/>
    <dbReference type="GeneID" id="22576397"/>
    <dbReference type="KEGG" id="lpan:LPMP_272190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270030100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_272190"/>
    <dbReference type="eggNOG" id="ENOG502QYG9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="17010at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047057">
        <property type="term" value="F:vitamin-K-epoxide reductase (warfarin-sensitive) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042373">
        <property type="term" value="P:vitamin K metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12917">
        <property type="entry name" value="VKOR_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.130">
        <property type="entry name" value="VKOR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012932">
        <property type="entry name" value="VKOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038354">
        <property type="entry name" value="VKOR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042406">
        <property type="entry name" value="VKORC1/VKORC1L1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14519:SF5">
        <property type="entry name" value="VITAMIN K EPOXIDE REDUCTASE COMPLEX SUBUNIT 1-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14519">
        <property type="entry name" value="VITAMIN K EPOXIDE REDUCTASE COMPLEX, SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07884">
        <property type="entry name" value="VKOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00756">
        <property type="entry name" value="VKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839082" description="vitamin-K-epoxide reductase (warfarin-sensitive)" evidence="13">
        <location>
            <begin position="25"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Vitamin K epoxide reductase" evidence="14">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AIN99598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="162" mass="18097" checksum="07F66535B05E3F84" modified="2014-11-26" version="1">MVQFNLTLMGLCLAGFLLSSYAYSVEVHVERAKQLGVPYRAYCDIGPFSCTEVFSSEFSSTTHLFGLPKVPNALVAMIYYMVEMLCCWHPTLILIISTPGILVTVCFAFILTVILHDLCIVCCLTYVVNVSTVYVAYRWWRQTAARNVAAAFSSSTKSKKHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUE9</accession>
    <name>A0A088RUE9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amastin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_281190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700459.1">
        <property type="nucleotide sequence ID" value="XM_010702157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUE9"/>
    <dbReference type="GeneID" id="22576564"/>
    <dbReference type="KEGG" id="lpan:LPMP_281190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280017800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_281190"/>
    <dbReference type="eggNOG" id="ENOG502SKVM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264655at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009944">
        <property type="entry name" value="Amastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297:SF4">
        <property type="entry name" value="AMASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297">
        <property type="entry name" value="AMASTIN-LIKE SURFACE PROTEIN-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="27652" checksum="60B439CB8A55FD89" modified="2014-11-26" version="1">MLQSTRLNGDASSDSNRQSSPPNAGMRGTSAAKSNYPTNGSFDNAAANTYRNIDLNDFEYIPTPFNPRRIARCRADNFVILFVLAVTFVASLAALLTPIFMYRSPTSTVYVDSRNVWGIKGDDVQQRYKIYTLFCNNYTVKSDGYLALHIMVLLLTFIGFCLALCPIICARVLFCTYLVHSLLCVSWLFVLIAMILGTKMYTDKLCRGTSLMIVGFRYGPAFAVTATLFSLLSVTGIFLIVRTIRNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUG8</accession>
    <name>A0A088RUG8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic peptide chain release factor subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_271710</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterodimer of two subunits, one of which binds GTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic release factor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700257.1">
        <property type="nucleotide sequence ID" value="XM_010701955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUG8"/>
    <dbReference type="GeneID" id="22576349"/>
    <dbReference type="KEGG" id="lpan:LPMP_271710"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270024600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_271710"/>
    <dbReference type="eggNOG" id="KOG0688">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10254527at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000006">
        <property type="entry name" value="Peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.60:FF:000003">
        <property type="entry name" value="Peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.960.10:FF:000003">
        <property type="entry name" value="Peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.960.10">
        <property type="entry name" value="eRF1 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024049">
        <property type="entry name" value="eRF1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004403">
        <property type="entry name" value="Peptide_chain-rel_eRF1/aRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03676">
        <property type="entry name" value="aRF1_eRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10113">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03463">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55481">
        <property type="entry name" value="N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="7">
        <location>
            <begin position="7"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN99550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="453" mass="50798" checksum="86FE8FDAB72A0E4E" modified="2014-11-26" version="1">MSGEKELTDAEKTIERYKVKKLIQMLESARGMGTSVISVYMTPKEQISGMVAKLNNEYGTASNIKSHTNKLSVQSAITAALGRLKQIPRVPTNGLLLYSGTVMTADNKEKKLTLDIEPFKAVSRSLYLCDNKFHTEELRRMLESDDKFGFIIMDGSGCTFATVCGDVKEKLGSFTVELPKKHGRGGQSKNRFARIRMERRHNYVRKVAESAVSYFITNDRPNVRGLVLAGSADFKEVLFQSDLFDPRLKEVVVKIVDVAHPGDVGLNQAIDLSADALSGVKLVQEKKLLQTFFDQIAMDTQQYCFGVNDAMRCLEAGAVETLICFEDLDVNRYVIIKNKGAEDEATEIHLLTEADARKKNIHAHEAGKTQNEIESENFVDWLAQNYQKFGCTLELISDRSQEGTQLVRGFGGIGGILRYKMDVIALRDHEKKEGEDERIAANNDEFDFDDDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUL7</accession>
    <name>A0A088RUL7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sn-1-specific diacylglycerol lipase</fullName>
            <ecNumber evidence="14">3.1.1.116</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LPMP_272110</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:33276"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="14"/>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700297.1">
        <property type="nucleotide sequence ID" value="XM_010701995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUL7"/>
    <dbReference type="GeneID" id="22576389"/>
    <dbReference type="KEGG" id="lpan:LPMP_272110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270029400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_272110"/>
    <dbReference type="eggNOG" id="ENOG502SI9X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052214">
        <property type="entry name" value="DAG_Lipase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792:SF8">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="16">
        <location>
            <begin position="464"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="408"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="742"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="408"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AIN99590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="845" mass="89280" checksum="ACD3A48F99BACFBC" modified="2014-11-26" version="1">MRQTQACEVLSPAAHQILSSSSTPASSSPTTSASPTLAAVATGIASSLTASRPFSWDRVKAILESYLHTDDGAYNRRAANVKAVLGGVCALLDKVIARYPTMTPLTFVKRYSVMQDLSSAHQTLYAACVASLDDTALLRGISWDEVRLHQQARTGVTATTSPTSVFAAMRPLRVDRLVFENLKTSVSGAGGNGFFPSPFSREATTPMTAQWTASNGNEDATPSTWPIAHYPVQFLLWQAMRYATAVYGEVYRRGSLSSTLSAALLFTINRSAVEVPKQVNDAAVTTLLGLPPSALQLSRWGSQVTEPSYVLLVDDVAGSIVVSFRGTLSTFDIITDLAATTQPFCGGHAHQGAAEVVNTLFDQRSSRYGERVEQRKKTGAAMTAVAGATDKTSATAEDATRHLNVRAAAAPSPPARRVVSVEEPTSFHSTSSKTDDIGAPEASKESVMTVLEPCALQPLDTPDGLLDGLEQLAAEHPSYSILITGHSLGGGVAVLFATRLHYDQALPPAVLKRIHVIAFAPMPTLSLPAASCFDEVSTRGDGGYSSRDTAPQSTPAACFPVWNVVNGFDCVPRLQLNTVDRLLRQVVEPQIAASAEVPSAAASSALTPATADAEHQVLRELCERDAAAHGADTGAHEEMGMVGMSAMPTPIVTVKASLARLPKDNTATAADDTVEDPVQASVFGVMSKVRTPSGLVGAGAGAVGAEEIGAVVAAPKEKAIASSSTASRSATSVAGTPQFDELLTSTDGGAQGRSHLGSLPLESEGRTYNVRDLSHELHHPGRVLLLTSPWDIITNRLVDVPRGHPVMHELFLMKSMLMQHMVDAYSASLREIHEAPRCASGEERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUR4</accession>
    <name>A0A088RUR4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Microtubule-associated protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_251460</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLUAP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699716.1">
        <property type="nucleotide sequence ID" value="XM_010701414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUR4"/>
    <dbReference type="GeneID" id="22575794"/>
    <dbReference type="KEGG" id="lpan:LPMP_251460"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250020300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_251460"/>
    <dbReference type="eggNOG" id="KOG3647">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="438545at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019366">
        <property type="entry name" value="Clusterin-associated_protein-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21547">
        <property type="entry name" value="CLUSTERIN ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21547:SF0">
        <property type="entry name" value="CLUSTERIN-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10234">
        <property type="entry name" value="Cluap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="4 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="290"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="166"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="441"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="453"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN99009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="468" mass="52766" checksum="9C099CE6BF4F4BBD" modified="2014-11-26" version="1">MRLLGYPRLISMESFREPNVELVADCLHWLIIRYEPSAEVTFNIEREHNRVTFFKQVCEVTLAKGRIKLNVKKLYQADGHAVQEMLKLANVLKKAMKATDAEEPDFTALHQMAAQKNVSDAKAVQQLCSELTTDGSSLFFLVEAELNSRGDRQRILSRATEVGEFERRLRELLTNVAQEVDQYQQSIVNLSADETNLEQKIENKKAHLERAQKQYKSAMATNPAFLKEYENHEKKLQAQFVNYLEQYRNLEFLEHQIAKYNAKEDVMLEEQETKLKVMRERLRKEELKNIRADNVASRPSGRRGSGSGSLTPAISDTEDDGYDYTPRMNGGVRIRNAAEEDSSGEESTSSGDDESESDDSRPRQQRRPQNTVGHSRGSLGHGGTVNTDNDNHEEEDESLVNQMRRPRVATGTRPPAAGGERPRYLANNPADTDSSSETDSSELSTPTSSGEFSSDDSSDYSGSDESDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUX6</accession>
    <name>A0A088RUX6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_290160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIN99967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700910.1">
        <property type="nucleotide sequence ID" value="XM_010702608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUX6"/>
    <dbReference type="GeneID" id="22576780"/>
    <dbReference type="KEGG" id="lpan:LPMP_290160"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290006600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_290160"/>
    <dbReference type="eggNOG" id="ENOG502RX0T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273587at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="569" mass="61057" checksum="2BFEA54A90FD02CF" modified="2014-11-26" version="1">MASSTRRGLLQLGAHSCVVQSLHIVFVALFTEYYVHGFLLVVDTPNVNTAGLTDMRGWRLRMSKLGLCALIAAQLVYIVCSALDRAGVVAFSSVAARAWRLAPQQCLGSNEHRFTFVFGVSWWVLRLPLVPSAVSFTLATAVFSIFSDRCTAYAQNAAREMAAQRPKEEPWVQLASRAASGGAAVVVLVAALLYDGSSPTREPLRGFHWYLLVLCIAAVCVLSGAQRWRRSGHGEGALSAAREECSVGSRSVSGFGDAAMVEFHTFVRQTWQRRSMRAFLVVRGLHCYAHAAVVGFFHLFLTLGCAPHLSASVRAVILTLVVAAPSFLAPMHAAGVNVVGKKCLVLVMLLGMFALSLVSLMAAFLTRGAADVAAASTFGEGSTAASSVAAIWLCAVLLTLLRLLLDSVRAVLDLAQEDVVEEDVVIFDRAAPMAAWSERLCAVVTAPMESLGRITALLLLAFTHAFEGVAMVSTATTSSTANPRVASMTPKATTALALRRAVSSSVSPAAVVTTSMAPTVLALLSLHTCGVTLTMLVVWHRYYNLEGRHLRFVQMTTRRRKDEQSVALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RV16</accession>
    <name>A0A088RV16_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_290520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700660.1">
        <property type="nucleotide sequence ID" value="XM_010702358.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22576816"/>
    <dbReference type="KEGG" id="lpan:LPMP_290520"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000044100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_290520"/>
    <dbReference type="eggNOG" id="ENOG502SEJK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="246689at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="588"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="752"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="886"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="970"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1074"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1192"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1322"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1388"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1567"/>
            <end position="1586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1776"/>
            <end position="1799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1933"/>
            <end position="2059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2132"/>
            <end position="2283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2302"/>
            <end position="2471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="304"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="752"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="762"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="822"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="889"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="910"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="927"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="938"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="988"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1401"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1423"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1782"/>
            <end position="1795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1933"/>
            <end position="1954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1957"/>
            <end position="1968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1969"/>
            <end position="1984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2002"/>
            <end position="2013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2014"/>
            <end position="2025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2037"/>
            <end position="2047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2191"/>
            <end position="2200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2201"/>
            <end position="2216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2346"/>
            <end position="2360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2396"/>
            <end position="2405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2406"/>
            <end position="2418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2923" mass="304741" checksum="4765A31A53BE1274" modified="2014-11-26" version="1">MHHWERSERLRKAASTPHAASFHHVGASLSPQMHKGTGALHESRDQGEGCGEEEAIVQRGKEEYSSQLASTQRYGGRPPMSAATAHRQVEGSVYTPHRTSPHASGELPSSTGPSTRFSDSPAAYHLRPFSLVEEDAAPNSAAATGGGGVIASPHRSAVGGVKERERDVVDSPFPSKVHCRVCEVTVFQSGWETHQLSALHQRQLRDCATACGGSSSSSRDPSARLAKVAVQGSNTLQMTAAAGSRTSQRPLISGHAQETSSSARPSARALTLSERNHQGRSQAAAAAVRRSSPSPRRCRRKLDSTSSETSSSTYSASSNSTRSGSSVSTGSSGSSSSSSSSNSAESKSSAARGHSGVSAVPYATPPRPAGPPSAPAAPSSATPSFVLPPLSPSGFSAASSASAAARPAPLPVKPLGSADAATVVHYVEFTEEQQERRHVQMLEQQLNKYLYHRENKVLAACVRRWYESMFTKATATITDAGPPKRGGGAEVVAGAPGSSEGCAVASLSPTTARARCITVVSPSPSPVSAMARKSVEAVPHEPGTLSVPSNFTGLAASASAADAMFLTQGRANYLNDMAKERVDEGYGGSLARRSNTRQPGSPSVSSPQCGMVPQTNHSAGVGAKCAASTGVVGAPPMHSEHAGMLRGSGEGESTCAPFFTTCVKSYARVHVAADGRVFPAEARRGSSDGSAENESQDLEVMQTKVSWLVQPVSQPVTARSSSSEPSDSVADGRDWRSVVGCSAAVVGAAAATASTAAPGSTYNSSQPSANSRGGETASGQARDKGAGWGDSSRAQPHHTTKSERSTVSGGRSFPPGQLHVAPSTSVTGYASDSNGGDEGVESGAVAPRTQTPNEEEGHASEVHQALHAAPASGTETISAAQAVLHTGGEDGGLDGVGRTGAECHLPEWTAGRRDGKEKSDRPDLSDSAVTAATATPSRETDTNNEEAKEMSCEPTPLTPEATVRIHAAPTRPADPLYCRSNLLDEVPPQQPSYPPAPKSTLSTRSLSSHAGALKGNHVTAASSKSPLALTGAQKELSSSATSSSLSSFHSNSISSESDIAGLVALLSPRSPQRVSQLLRPGSAASLPTHSTGAPKASACVPDTHPFHEFDLAAAVVSAVRRPINASIAGQGEPAAQTEGALEAPLRYLSDSPPPASASLIPHDAHERGAATATLSVANPLFDALTGVLGGDGSHAAAPETGERSAAHGPHHHHHRYSGYSRGASTAVKLPKALLALHVMSTRGAGSSIAALSADALDERVSEYDGDAAAPPLEPSTSFAVDEMRAEVGWAPSPSDHPYNVSGPTCFGSGREWCGGFSRPVEGQREEVARSGTSSSRGGRGRVGPHFFLGAKFAERKSGNDDESSVAVLPSTERYDDCFFVCTRESAATPTHNADEGGGQQGTDASEETTSLENNGNGEGALSPSATPLNDLSIPQSPVPPSPASATAVNERDTRAPIGVPPAAQALASSFAANAQAEPAVVQLPDAEICMHAVREAQWSSAIVAPSAGLAPGSDGAHSKGAAGVGPLCTTTHLHKAVSDGPDAVLPSTNCSPTASFFTSPSGVMTAAKPAGATAPNSAPAQQHLGPLRGPLQSIDQEAEERLLPLDHDLHTATLATSAAIESGGDAPLWRPSPVSGSYGAKPTCDAPQNSFQPTTTAEVAGSSAGWSDTAGASSTALVRATAQLSTSPCAAVAPCSTVDSVDASLYDLPSLEMPVLHPQGDGSGLEKGPPRLTSSRQLRYAHLSRATAAEAVAGCGNVSLSAPSALLPSVKSAECSPETFAQPPQSMLGTHSPRLSRTPRLSDAEAGICSLGGGTVACSLTQPPVATEAGALSGALAPVAVGTARTVSCLPPNVMPAAHPYCYATLKGSAGDGLRTKRGGCTSSRGSVATAPRLSFAALLSLRAALKESVPNGASALSTVLTPLTAATAAGLGAARDASRRTSSSSSCSRLGSAGVHPHRQKLRHHRHRDESAASQERRRAERREKRRSKQRSHRDGDASPRHYRQHRHHRSDRRREENSYDKAFRSQHQCHPCPREKHRSPRHKRDRPQTEDTDAVAASRVHPSLQCVLEAARQRRHRDADFRDPHYAAKGGGTELPFGSHTPHPYWLGLPSVPVGPSASGHEVLIMRGKDHDEQPGAPCNDDVTHAARQHRSHRSGNSSGAPCIRDGEEDDDAAPRGPLHRRPSERQRVPGHRNRCRRMPSTSLSPTSSLSSRSTGRDVSVDSGRGSEAARTGPTRRGGATAWISASPSRGGNATRGPENGGVPEVGTEKVSASEHDRSNALEQSLKASLQQPILSIEPRRGECGAQPPFGSALESAGDHSRLTRASADLPEISGPSATAKAASDAKSDDFVRGKDACSKGICSLDTRQPPERASSERATALELPAREDGAPFSTVSHTSNRTSLPASAPAGLASGRPVPGVQVRGSGAHESAFASSTELGNPRRFSADTATTTTGRERDATDGQPTLPQHGDLFYCDVAGRFHRVSSAELESLLADEAGRRISPQRGQSSSGSPRRPLYVVHNPTLSPSATTRWQQHRAWTITNPTGSLGCGRLNPYCSSCRAKYNLMFVDPQMRPVQWLSAQSAKLNQMGDCRTHSGYIFGGGNTASERDAMLAQQRLRAKRMAAWPELPHCDRDHLVVHEEDLDGPLRQLAAPPQGRFVPIVYKEDTRRHINPALRHRGPPAAASARQCFVFSPSSAALSQPPRHPSPAHFFGDALRFNTSSARDRTNGCPPASSAHLHHSTTRSGTCCHDSYLHNTQHGQSSSHRLHMDSGFYNTNDVGSASIIHLNKFAGVADAESGQAPPRSHQTLQAVGAAKGMVGSDAAASASASAAASGMPAEPSSVAALRREERRIKRALKQMLWRDLPQQRGTAQWERYVRSLSEGLRQRPHFALFPLPSLSAQTVETVQPTPIDGAAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVM5</accession>
    <name>A0A088RVM5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase, putative</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_262070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700026.1">
        <property type="nucleotide sequence ID" value="XM_010701724.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22576110"/>
    <dbReference type="KEGG" id="lpan:LPMP_262070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260025400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_262070"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0586">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="245043at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001848">
        <property type="entry name" value="Protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF31">
        <property type="entry name" value="PROTEIN CBG02007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="635"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="676"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="984"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1024"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1065"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1137"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1237"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1456"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="591"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="732"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1032"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1203"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1458"/>
            <end position="1468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1780" mass="188336" checksum="9CB30D71F03D5DC0" modified="2014-11-26" version="1">MSDVPLHSGRTTIHSNNAYHDVGEEGDQHLGQQKPSVRDSRATTSVEPMTAVQVVDRLRWWRTYRVREQPIPVDHVVLRGCYANYSSFGTRPLASGVARLLQKARAVREQYLRAQQQQQQPQQQEEEAQHQSRQCSSLLIASTVGTSVRSASSERLHNGAREMERATGCMADEEEGHYGGRQQQQHRAMNEKAKEKLDNKRRAAVTSSSLPPPRPLSEDTAAFRGEPAVQRGSTTTHVLCSPLSVSGSVGTFSPFVRAAAGSAQALDTHSCALYVPSEQEARAAERLLMLFRPRAASAPLRSCRHRYAAGHLDVASRELSGESPLQRDRGCKDAAEPHHKRMTCISASDEITDVHRVPGAAEAVIVLHHAPRLILYEKGLNPKAALWASDVSSDAFENLNDAAAESSAEVFALRNLPLCAFERFFYQQQLRGLAETEGSREPVLPSTSPVAVNAGAESAGVPAGDTASAPTGAAATTGISRGDNCVVNGNDTLFFGSPLTAVLACSLKGTVSLLSAAAGAPSCEAGDTSARRVAPYRGSGRGSGRNNRRRGGRAALRAVSVPVLPPVYKGGCPEMGAPASHRHRSSRVRLQRQQQQNPSHPSSILPAGLRSGTVSQDVAHLCLRVDDLQDVYVFNPVVDMIGKGAFSKVYAAVPILRGKEGLRRFASPLLSRQVAPCSSAELGGGGPQEGGRSASIARRESSTHEALSSPALRVDSAAETAVGDTAGPLAEDESRNRRPHEESLTVSLRSIPVVALKVIPRKARQKPKAPLGSLAAMPSAAAAVTGSATSNVQQAAQNDGDSVRRELVEIEREVSILRRLHHTGCSQFFEAIRTPDAFVIAMRVFPGSMDAQHYISRYGAPSEARAALLLFQLVSTVQYLHTTFGLIHRDIKLENILLSEADASVPDTRIFEVLGETVLKSDASTIMTMSACGRQGCASTTVAVGTRTAAQHSRSRASHNVTRLLRVTLIDFGLARRTRVNALSPTASASHGRGSVARHGSLNASSTSPTYIASFPPTSATLAAGTAQVHRNTSNSSFSGSLGSPASLSTGGAAGAVMHFNSGNSSSDSYAAAKRAPPRPPLLCRPPSTTVGAGMTHHGPGGTEFGGMECTMSRVGMPSPMPSTANMFTRFLDVEEEMDEEENGGAGGAEEWCTPANPLTRARGFGPSSRQDMAEGEDDSGAFSTGMSASETDDEWEGGSTAEPKEGDTQEREEHSKSWPNKEHGARAALLSPSVLTAQPQTPPGAAVIPPQPVPPTLPLQAGTTAVTSSHFNAESSGSCCTTGGAGLRYRCASCIYTSQHQLPPATAADVHSTPDDTEATLLLTPCGTEKYLPPEVLSWILENGWARRSTTVGLARAMDLYAIGIVAYVLLSGCFPFNASSRATLLQQQQRVPRCNSARWAGVSSAAISFVQQLLEPDPRKRMTAKEALEHPFLHEARQLAEKLSLVPHVEGEEVSHPSTWRDSSQIDNHHRPGSGSPGRYYDDDANVHARWHWATSTTATTATATGSLLRSVPSPTHADHTCSGAAMELTSAYQNAILSFATNDAQRPPVADQNGVVIVNESSALNSSTGAHHRSAGGSGELAPLHRVEGDTASMAIRLSGSCHLPGVPSVCRSSDECEEDDLLASITRNMLGGVPPLLQACKESLSPTRSLAPATTTTSTPCAATMARAVPIELLASPSLATRPVKLSSFSTPLSPATGAAPSVDGAAAKRATLPEPTSAAAAAASVPALVPSGTYDANVNRNVSPFRAVTTTTAEVVESGGDDLFESLYNNIMLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWB2</accession>
    <name>A0A088RWB2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="6">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">MKK</name>
        <name evidence="14" type="ORF">LPMP_292340</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="6"/>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700838.1">
        <property type="nucleotide sequence ID" value="XM_010702536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWB2"/>
    <dbReference type="GeneID" id="22576997"/>
    <dbReference type="KEGG" id="lpan:LPMP_292340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290025600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_292340"/>
    <dbReference type="eggNOG" id="KOG0581">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000744">
        <property type="entry name" value="Putative mitogen activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF9">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="63"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIO00181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="372" mass="41684" checksum="58AADFD3D8AB2783" modified="2014-11-26" version="1">MKNRPSLVLDAAVVEKFQQDSKSYQINSNNSLQFRAFLFSEAGMYTKDGRELPSTVKKDDIDYSSKRNVGAGASGDVFFARLKTGTSIALKRIPISSKAHRDEVDRELQVFMARGDSPYVMNNYGAFWDAEDDAIVIPMEWMPYTVKDLGLFWGGFNEQLLKAVFFQVVSGLVYLHDVKRVLHRDLKPNNLLISENGYVKIADFGVSKLIQTLAVSSTYVGTMCFMAPERLEQGMYGFSSDVWSLGLTMIGAVTGKNPWAPPEEMNLYQLLDKMANGSTPTLPKSGTFSDDVKDFVKQCLERDPDTRPTCAELLRHQFFAGVTTKSAVAMVKMAVEQMTRLINNNAQKEKEVARSHESLEKDVKAQLDKMVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWL4</accession>
    <name>A0A088RWL4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_302010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00424.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701224.1">
        <property type="nucleotide sequence ID" value="XM_010702922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWL4"/>
    <dbReference type="GeneID" id="22577254"/>
    <dbReference type="KEGG" id="lpan:LPMP_302010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300024300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_302010"/>
    <dbReference type="eggNOG" id="ENOG502SI5Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO00424.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1208" mass="132719" checksum="96E856FF0E4D911A" modified="2026-01-28" version="2">MASLPDASSLAPLPDSLAEVEMELQKTHETLIDKIQDELVCVVCGSVFIDPRILQCQHCFCLRCLYSTVSRERTSQIEVPCAYRCAAVTVTQGDIRTLPKNHYITNTCVLLRQQLVHRARLLERKLSLNAAADNEALTPSAERRGDSAALALTAAAASPVTVAAFPSQAAPATVTHTVLKKEMDAAKELYECEWCSCASPTCEVCPYCWSRICVECRGQFSDHQYLCLELHQPGRRPAEGWLPGASTATVSDTAQDAAAGQERGVTAMNRRGSAAEMGAEAAAVAQTPDQEAPFPYFITPFFVPVLVKECLMKQQGVAMRPSEIDVTAVMAVRLAVPEVEVQCQHHTTGFGFDFRIHPSFKTMEGVEVDLTMPHWAEDGGRPNATLSFLANTARLGETVLQDLRRLSTVVSNVVLELSSAAHQASVRRNKGFHMYAVHVWSLARSQCVIARDALLPHLERSRLLENMMGDLVVYHFQQTASHASPPQKHFIRDKCVAFMKAEVQLCRQLDQIMEGVDAVCRGIHTLLTRMYTVMKELAQPTAHRREENRRSQQSRLRFSTRMFHSRQQEPQASGEHESYACASTSVDETVLSPRTRVRMIRLLSRRLPRAGTVPVEVEAPLTPLPQNVADAVPDTILSDKVGEPDCSFHVQVAEHGAMTRTLTESMLSILRCFMQARVWQWSLSNTCIRECGLSEGDRRTLLAVEEELQLITDNLLHCMWASSRMTYIMEVEQDAAGPASSLDILMDAETLELLKGELECPMYDHSEVFESLKALSQLRAQFVSFSSAISIVARNPDTQQELLSMMSSVLSSTMTHQTTVLRLVAQATTSLNEYYADYLRTRQMNPTVGERPSPSEDTLLAVDVLKLLQLQSDEQLADSLAVMSKMRDHRDDDGLRGAHARQGIHCANLSAATQGGRLSDTDSAPAGGGTALRSRCPFRTDFSLRDTALSSCQAYGEALVRAAHGEPLQAGFVPEGQPQGQQSEEQASDAEVAAEAVAEMPSPSAGAPKHSTELVDRTVAEQTEEMVPEPLMSSTASSRTVDADAQRSASMLRTTTAVATPVAHDDGGRSARDDDTPYRESLFSADNNESVVALTRVSPSAADLDGIRKAAKLFGAAFQLPATTTSVGRRRLVLLPFYHGECIYKGLSTPFYVDGQTGTVHMDPRTLSATGKSQYVLEVLSSPLFFILFNATLSIFLHRQCKVGIMYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWL6</accession>
    <name>A0A088RWL6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4139 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_300980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701131.1">
        <property type="nucleotide sequence ID" value="XM_010702829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWL6"/>
    <dbReference type="GeneID" id="22577152"/>
    <dbReference type="KEGG" id="lpan:LPMP_300980"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300015000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_300980"/>
    <dbReference type="eggNOG" id="ENOG502QWQ0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10068793at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011935">
        <property type="entry name" value="CHP02231"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037291">
        <property type="entry name" value="DUF4139"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02231">
        <property type="entry name" value="mucoidy inhibitor MuiA family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31005">
        <property type="entry name" value="DUF4139 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31005:SF8">
        <property type="entry name" value="DUF4139 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13598">
        <property type="entry name" value="DUF4139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4139" evidence="2">
        <location>
            <begin position="230"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="167"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="579" mass="63821" checksum="FB036A6845442C61" modified="2014-11-26" version="1">MSRVTLKPKLEAVTVYSDRAQLTFSAPVVLEPSASITAVVENIEQWGDVDWGTLQVRINEATDPGVAAAVLLQNISPVRETVSQDVRADVQWQKDVIKRMEEEQCAFEEEVAVLQESCEHLDRIKSFVCCAGRGDCAVPPENAVHLQAYLQAPARWGAMASFFATRRATAQRGIAELRTKLREMEERLAEAHRQLKDLGGDSGVRWYTKNALEATLVVGAGVASGTKMVVELSCVVSGAGWSPLYDLRVDYAESMLEVLYSAKVRQCTSLDWEKVRLRLSTATPHAGGSPPPLWPRWTISMRPPVSVRGVLHGGQQVHRRMAPAAITFAVSNNMEFLTAPVAPMVKQACVESCGSSLGATVYAIPGLSTVRHNNVDVKVTVARERFPARLRFVCVPKVDPLVHLSATAVNATDYEFIDGPAKVFYGNTFVNQSQLAHVSPGEEFEVSLGTDETVTVSRTLVRRAESEKMAMFSSTKSQLRYHYAYTVECAALPNNAPVTVVVRDNYPVSDDTDVDVVLEQPKATERGENLRSAKGATVTVDEDTHEVAWSFLMTRHEKRTFDMVFMAKYPVKTPVFGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWU2</accession>
    <name>A0A088RWU2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Superoxide dismutase, putative</fullName>
            <ecNumber evidence="1">1.15.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_302710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.15.1.1" evidence="1"/>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701294.1">
        <property type="nucleotide sequence ID" value="XM_010702992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWU2"/>
    <dbReference type="GeneID" id="22577324"/>
    <dbReference type="KEGG" id="lpan:LPMP_302710"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300031700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_302710"/>
    <dbReference type="eggNOG" id="ENOG502S57Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275227at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42769:SF4">
        <property type="entry name" value="DISMUTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42769">
        <property type="entry name" value="SUPEROXIDE DISMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO00494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="268" mass="30118" checksum="223CB2A8372A97D3" modified="2014-11-26" version="1">MRVSVLQLFREYVPKGAFTHVSLALATPHGVTRAFRTTEMAAAAADAERDAKGFFHLPRIDYDVSQGVAPLMTRKQFDVQYHVFHKAAVDQLNTHTLGSELEGHNLNVVLRNSSFDASRAVIHTAASEHFNYCFWYRSLRPWGTAVPTRLRDGLQLQYSQNGTVDAVGEVQRLFAVTALSQQSVGGWVYLIWTGKAFDVLAFDHGTCPLGSDLIPLLALNTHESARCYDYPLAEGDEEGDNVERFVRNFFKTCNWKLAEHYFLQCGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWY9</accession>
    <name>A0A088RWY9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chaperone protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_281360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700476.1">
        <property type="nucleotide sequence ID" value="XM_010702174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWY9"/>
    <dbReference type="GeneID" id="22576581"/>
    <dbReference type="KEGG" id="lpan:LPMP_281360"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280019600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_281360"/>
    <dbReference type="eggNOG" id="KOG0714">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44743:SF10">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44743">
        <property type="entry name" value="PUTATIVE, EXPRESSED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="19"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="450" mass="48813" checksum="DD09DF00A5BBB165" modified="2014-11-26" version="1">MAAENTKLNKMPSKASAPPHYECLGVDPSINAVDLARHYKKLSLQLHPDRAAYRNDTDNEMHVRARYQRITEAYAVLSDPEKRSAYDARHGVNFRSRLVHLQTAIGQHNTMAMQRTAKGQKTAGLASSSSSLTHPCATRHPSAAPQNISAEDSDDDEDYAPNEVSVPLRGARHQGSSNVSPSEGSSYEEGDCVARLFSLHLRRGAEAAPQTCNGVPVTQYQALTLTRAFSSPGSPYARTWGLIVEKNELVGLEVEYPEELESITGLAAVPFPSVVHQIDGTVVLPTTDLPLLLSRLYDAECARRSAALAATSHTAPTSNNTHFCESEKLCEAPVEVSTASVPSSSTEHLQLVLAYSTVAYDLVGEVHLLGDDDVIDRLVPSCCGVPQLRLLMPDATVLSVNGTQVRSSTELRTALRAAVLDDEDEDAMQAVKRARTSRAVVVEFCQLPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXH3</accession>
    <name>A0A088RXH3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_310800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701469.1">
        <property type="nucleotide sequence ID" value="XM_010703167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXH3"/>
    <dbReference type="GeneID" id="22577506"/>
    <dbReference type="KEGG" id="lpan:LPMP_310800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200033500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310013300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_310800"/>
    <dbReference type="eggNOG" id="ENOG502SHJI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265961at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="432"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="508"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="596"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="633" mass="70605" checksum="F7F541D036580317" modified="2014-11-26" version="1">MEERPAFPSHEPTNTTEMRDGSPQAQTHQESIRVPNRDNGADADHQVNGNHPSGFPTVDQPVLIEDMVARVVLHESRPIENLPKMISPELKLIGRCVTFQVKRSPNGAPGDPYYYTGLVSAVTANTATLMHVNRYTQHDFKTYQSREQRLAKGKVSTVGKDRDVGNHRRRPFDQEPTAPSSGLPAPSTNHGLSFYGYSADGEVGVAEDGGISNALDPPALLDLHASGSLAPSAALITDTQLYAVGLLEQEQQQQPRRNHTPVEVNQQLSRASGVAWCKQFRAFVGSIGPIPYVTFLRKNINNVTFGRDPRSSFYSLFKDPARHIRDMQLLRMFVRRYLVHTSQGNNPRQVLLYAFLSVRCAWPDVDRELVNRVALEELPTLLKADCAIEKERRRKLLRVQYREQEVQHYRAPAGLFSNTGILYLTNIPQHSFIAGIVLIVFALLFAIYLGVVFGTTKDAIIVSYVRKFILPFVISLVTWTVTGAAVMLHARTAHIPLLADYLGLGLRIVGSVASIGCCIMTLLVVFWRLTKEAIYLLMVEYKETELCTFYARHSCTGLFVACGLGVADPELCLSCTGMPVTNTNCYSFLWTQIERAVVPLLLFSCVIMVAAVYTTYLVVKMLLFVEVLMGRIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYM8</accession>
    <name>A0A088RYM8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4200 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_322100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701894.1">
        <property type="nucleotide sequence ID" value="XM_010703592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYM8"/>
    <dbReference type="GeneID" id="22577951"/>
    <dbReference type="KEGG" id="lpan:LPMP_322100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320026600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_322100"/>
    <dbReference type="eggNOG" id="ENOG502QSDI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264063at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051147">
        <property type="entry name" value="CFAP_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025252">
        <property type="entry name" value="DUF4200"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21683:SF3">
        <property type="entry name" value="CILIA AND FLAGELLA ASSOCIATED PROTEIN 100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21683">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 42 LIKE-2-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13863">
        <property type="entry name" value="DUF4200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4200" evidence="4">
        <location>
            <begin position="103"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="524"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="117"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="428"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="524"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="551"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="578"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO01094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="745" mass="82051" checksum="91BC6EF49CBD130E" modified="2014-11-26" version="1">MDSSARTNPFLAPHGGGIQMESACISKELLQEVRRGDAAMADDLVALAPRCGRAFRLGTSVASPVDGVAVSGTLSRAAASSAACGDSSGYSVDVHDTLTTSDFVQQKREVGLVRMSLTTKKAEIRRLEEKLHRAEKRLRQQQEQLSNTRDKFNNFLKFSNLEQDAAVRRADDETRSKHAKTVEIKKLSALISNAEAEMRKMRLEIENCIAYKNFLESLARPQWFYDTLSSLRIEDATEKILLDAEEVYQARSAALRAQEAARLEAVLQAEQTKEREGASYGKRNPTSVALATQRMGVQHGKDRPVVDEEEEPEVVPLEEQLEHLYSSMEEEARAAIAASTASIRAEVSSMALAAVKDELHHSYNEERLPMCFVSVDDLLEVFINVEEGNLFLIQNCHELEEELEGATMGFMQEQEEMNTMFTQRTAQLEALTRSVAEAQTKLQELDERMEVLEPRGKHQANTTAGSTATAFKRATAGASSTGGARNTAGGALVANMTPEELRKKVEESIGHIFHLLRTGDQQLKITAQSSNSRKTTEGSKIAGSTIRDQSRAASVSQRGPQASRPSTTLVVRKKTATGGPSSDSQRAPSAVGQSVKKSTVALTAAAATNAASQQHQDASMGPVELLTIIENKLEEYHRYLNDPANHVDLALMKAVMKQSDKQRRHQARIVHLACQEQEQEERIRRALERSQAPLIHKTGKQVRPRSFVSKPMDKKSLRKAERAAAVLNGSHASIDSDEDGAEFFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYP8</accession>
    <name>A0A088RYP8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase alpha subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_321810</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase alpha subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701866.1">
        <property type="nucleotide sequence ID" value="XM_010703564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYP8"/>
    <dbReference type="GeneID" id="22577922"/>
    <dbReference type="KEGG" id="lpan:LPMP_321810"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320023700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_321810"/>
    <dbReference type="eggNOG" id="ENOG502R95C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="245242at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.60:FF:000013">
        <property type="entry name" value="DNA polymerase alpha/epsilon subunit B, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016722">
        <property type="entry name" value="DNA_pol_alpha_bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061">
        <property type="entry name" value="DNA POLYMERASE 2 ALPHA 70 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061:SF12">
        <property type="entry name" value="DNA POLYMERASE ALPHA SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="7">
        <location>
            <begin position="335"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="202"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO01066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="730" mass="78900" checksum="CA0A2D2595468D9F" modified="2014-11-26" version="1">MQVEGNWKAAANLNLLLGLEHPPARLEKTLLTPQQCRVGSSGSVKVEARNTASFRSSSYCGLQDKSAPTIRKHVIDYYKEMLHRVPLWHGLVKTQTESAGWNKVVKPEPQDEDSVPGMDPQAGGTAPTFGGSLFRAVGILTQVQDPSALSVTTQQTPWEFYVVQNMDDDECYRHALQAMGQTNCKAEASFALLQDASHTGFSARTSGRLDSSTGRSSTGVAAKPAMGEAWEETRGRAVEADEEAAVRDGIRLSLYTRQVSRFTGLYPGMAVGIIGEPFQRSTRGVLTGILVREFVLPSRPMLPWRVDRPLLSASMTSNAGTGGLTDGSVSSVRIHFCSGPFPRRDVSALLRMVTCQALHRGADILVVGGPFIPPFASEFERDLLPSLGATFNEVMEGFVDILEETLKNYYSTRPLLPHMKVLLVSHRDDVTQVPVLPTTMYAIADTDDILIRSNPCRLSVNGVHVSVCNEDVVGDMRERMVERWPTAEGSLRRVVEALVNGRLYAPLYGFPVTTVDLKHLPHLRMDYVPPQNELLEMKPIAAVSTSNSAAKVRGRSDAESGDALTSTSSAISSRGWEAVFNVSAQPSTAMTGSVKEKIKRVKLEELAGDQEGEEEGGGAAIASGGLVIPSTAAAVPTTEYLPHIMFLPSSRPQFAIVTHQSEEVDGADLDNAASASGVLVVNQEVWSTRSSPTFQLRVAEVTIPNTDLVLRRGASSANGVACGVLHIYSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZ75</accession>
    <name>A0A088RZ75_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Conserved oligomeric Golgi complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_323370</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702021.1">
        <property type="nucleotide sequence ID" value="XM_010703719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZ75"/>
    <dbReference type="GeneID" id="22578078"/>
    <dbReference type="KEGG" id="lpan:LPMP_323370"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320040200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_323370"/>
    <dbReference type="eggNOG" id="KOG2211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18786at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019465">
        <property type="entry name" value="Cog5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048485">
        <property type="entry name" value="COG5_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049176">
        <property type="entry name" value="COG5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228:SF3">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20649">
        <property type="entry name" value="COG5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10392">
        <property type="entry name" value="COG5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 5 N-terminal" evidence="6">
        <location>
            <begin position="5"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 5 helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="655"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO01221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1036" mass="110938" checksum="8F14C4575A271D81" modified="2014-11-26" version="1">MFSNEQLVSPDFDEVAYLRYALRSANYNAEHARLESCIAGVKRDIQSTLAVHADSLIDQARCTYKTQHEVTAVRQSTDALQKAAGRLRIMIEEPYMQLQSRVKELEATQEVMQLLQATLRFISLVARLQEQLATTSALDIVRSSYTLKELEEVLQDGAVRTLQVVEAQLPAVERHATTIRSKAHELLAMTELTAPPNNTSAAGAVTSTTASTSRLAAQVSTGLQCAYVLCMLSRTVQSFMTERRREVLRTIMRELDVQAIEEHISSEYNRLSRSALSGQSGAVSEQAVTAHVVLQRIQKTLFIAVQHTRCVILLWRLLLQRRDTQSQEAYLFSIDSPVQLLVEYWSTITEKLRERMNSLQKRHAIRLALVSAYPRYHHLLVSFLSRTDVAAATEGPLNAGAPGGASTDSVGSTAAGGVGPAAAFLSIYVTQCGMGDYLDLIDAVDAAVRHGVAGGGGQGAPYSIPDESPSSALPGTVTLPRTDTQDMRRTWLSQVSDEARDGFRTHVLDRHREVIGGVFARLSGVVPPSAAAAGQPAAVAPMPMHGSSRPSIPAQVKSLDMAVYTRLVKQEMQTFCQDPHILDVLLDCVLSTLRQVRAKLTEAIKKYPLPPLPAVTAVPTLAQAMHLCIANSCTTLAYDCATVLVMVPYHTTSQTAGGGAGAGGTTAAPNAMSGTHPHAHQDPYALILEQVGTKRMELQQLIHAFHSISEQSTKPFAESAMALLLPTLTQAVDNVLRHELALSSTTVSASAVSGEGMRVSPAMPLGSSRGGDSRMALVQLQSQCRQFTDRFFFLVDARTAGWMETCQYVAGALLARLVTRLATTPPPPTLRGTPLTIAPAYAHTLQVIVPPLLQFVQMVQSAGEVGRTTSLLRGCVRQVEGFYETCGGLDATSTGDGASAAAALRAAVLERLRPPIPYFFAKLLVLQYGLFTIASAPSADSQGAASPSALASALGVSEEGLLECLEGVLLTESVASTIAASSSAEGCGASAAGATRANRKEEVVAAVDACFLKVVAAAPDESVAFLQELWASIDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZB8</accession>
    <name>A0A088RZB8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vesicular transport protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_310350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701425.1">
        <property type="nucleotide sequence ID" value="XM_010703123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZB8"/>
    <dbReference type="GeneID" id="22577461"/>
    <dbReference type="KEGG" id="lpan:LPMP_310350"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310008500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_310350"/>
    <dbReference type="eggNOG" id="ENOG502SJR1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140284">
        <property type="term" value="C:endoplasmic reticulum-endosome membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055777">
        <property type="entry name" value="DUF7353"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053012">
        <property type="entry name" value="ER-organelle_contact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46384:SF2">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46384">
        <property type="entry name" value="MOTILE SPERM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24044">
        <property type="entry name" value="DUF7353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="64"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="993" mass="110628" checksum="2480B144B3961AF8" modified="2014-11-26" version="1">MFQCPCEHVAALREVKRAMGVHHDYLDGWLYLFLANKKFDIAETVAKLRRRDDMERTVFAKYTMTDSLRKSMRAGIVQYIGRDKEGHPVLYFNTARDRPTAAQRPERQANLDMFLSWAVRCDRKNPTAMVTWLINQKNASVLRNTDLIFQKEMALRISKFFPGVVARIFVCNMSSALTYVIRPLLRQLPRTISECIFLFSASDINKGELLKLIDPEVLPVEMGGNNDCDHSPNYERFATTIECYFDRCIRALSEGKSIKEMEMMEEFDVDKHGAPVAPATEGVAAGYTNSTPTPNDATVIGSTEAYQNMSTAWSNTTTTPSEETLDFAIIQEPCTVVVDNEGQRGRIQGVVQPDQQGERLVPLTSGTVAIDWNTLCASSSASLPSLISHVPSTNLFDCVSEPGESMGDFADSTITREGLYRVHLSSIEEFSYSVILRKYLAQGQGGGCGGAISEQWDACLRDWISFRCQCVELVPKLEHLLEALRLGAMLSEDEEDVVTQLRRCSHFMLNLFPQTQRMMRFHLLDWYAVGATTHYRTAAAAAASTTSNKTVADHGVVDLLSVNPRRLAFQLDCTSPDNVLLSAQAGAIEFVENWDDLIALDQRMGRVVRRLLLTWPPQTGRVTFEAQLHSRARQLWEQLTPLFRVYIEAKVGISLAEFIQHYGLLVPGGYIDETAEWYRLLFAAVLRYRELHRRSWLFHVFPPLGHADVRAAEPPTMEELLQAHGDAVTDVKAAVSLTMLVEQSLRYTADQLSTDGAGGAVATRVTVERYLEASQAKVFIPYETQRSGVLPSESIAQYRRAAATCLKNAEAPLQEFLFTTVSLFVLQREYPPDMTEAEIMAALQRSKKQSAVNMQERREHQQVAISFAGVCSELQGSFGSDIHGLLTTYSAPDMPAYGYALGLELLLAVAILKSRRSRSGSGGRGGTPLQTSCKLLSSVTAFSENDICAMSDDTEVRDVGAPSLVSAQSLLETLNAMSHPALRLASLKRMHIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S040</accession>
    <name>A0A088S040_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_332800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702371.1">
        <property type="nucleotide sequence ID" value="XM_010704069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S040"/>
    <dbReference type="GeneID" id="22578433"/>
    <dbReference type="KEGG" id="lpan:LPMP_332800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330035900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_332800"/>
    <dbReference type="eggNOG" id="ENOG502SH36">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267070at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="699"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="760"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="508"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="760"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="770"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="840" mass="88818" checksum="0A4CD457073693A0" modified="2014-11-26" version="1">MSTYEWVIEQESPDGVTTRIVFDFADGEVDSHGNGGRMNMSSSSYHMQNRRDGRARGMSGGASAAGGFIALKEAARSEGGSSRRSSKRSNGSRSHCQRRHHLGTSSRDSTFLGGARGNGGSSENVRGTMAGSTSSVFTSAGLRQRYQRILFGGGRGGIAAPVAGVKRVVTATSDTTAFVLTTGPMASTRVDASAGMNGDAQSFISSSPHGATADGPLPSTLFMSAYGAEMADEDENQSSSSCPIQRSRRSTRKGGCSGGAGVSSVGCVSAAGDLTDDTFTGYGTARHSSVQVPSATTAAPLPLSDSHHRCGETCNDSSDDDLADDTNIVKEDDSYSMLRDVWAARAACPRSLTTTRAMDFPTFPPLHPISVEEESEAMETMAESCRPLAGGPDVRDVLSGAAGAKTTYRVPFATTTSQEATPSQTRADATEDILRYNKMLLKKERQRRRGRGWQSAGPSGGSTHSLGRTFGLYVGETSRGLCDGESVSVKRYRRNERAVVPRGKFDSYRSASSSRSSDSNEDDVDYESCDTSSLSSLECLSTSSSDDFDVRELRADSVFASTVQSLASRAERERKKMEAREEQMLWSEAVQNTGALIKRRSQLHSDTIFEGLLPSANVAAVTTPASPVSLHAVPRRGDAALACGLVRNGAVSGTAYRNDSVSSFFISPIHQSVAAESAAWTAGTGFQYLGQGGLGGNSTMTSSVLPSSRPAPLQRCGSASAPGRPTVSRRRGRSDENNEGCVENLNDPCGGGALSSAAQAVVSDAQTGTRRARKKRKRGDRAHQSVVGQCGGSRALRPVAAPSNGPPLEVLPCSRKDMREDLLEAFLMEAMLDEDDFQLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S045</accession>
    <name>A0A088S045_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Guide RNA associated protein, GAP1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_332850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702376.1">
        <property type="nucleotide sequence ID" value="XM_010704074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S045"/>
    <dbReference type="GeneID" id="22578438"/>
    <dbReference type="KEGG" id="lpan:LPMP_332850"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330036500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_332850"/>
    <dbReference type="eggNOG" id="ENOG502QUEN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269740at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="CDD" id="cd23733">
        <property type="entry name" value="RESC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057320">
        <property type="entry name" value="RESC1_2_CYTH-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25477">
        <property type="entry name" value="RESC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RESC1/2 CYTH-like" evidence="1">
        <location>
            <begin position="176"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="501" mass="57005" checksum="23411C3AFF3460A2" modified="2014-11-26" version="1">MSTTAGSVLHRHLTSHYRASGACFRFASSENAATALAHSLRWQSSAAPQKDFSHITHDLVWGLWNEGNLFSLSAAELMYYLQQHQQRSDSSMLVIDPQAKKSTLVRQVEEVLSAEQANITVPQDVSAAVVMTGSDRVEETLDEADEYGDWGAEPGFEERRHIDYMEFNPLRMGERYEALVPRAYQLLHSELSADIGMTAVDPSKFPGQSKNKLAYLVSKVNVDKANEQHFRRGLEWCLANLWNTNMSGELNIGAGRIIFYRTIAKQNRNTLPLWTLQRHLYAYHPYVWFAIASASNVEAMEKLAERLGMKLVQDATTSYKVNIRRAGDLLDGELNAQLQCTKVNRPWDRFLITHYVRSQMPDLRFLVRARHPIKKRIVDAYLEADILRSTRDSVQSVLSPELGEVGYCCERVIRKWAMRTQTGVTLQLVETRRTPLIITKAGDEGERLEYEWIVVLPQKAERIDIVALSEELWGYGNLLAKELEPGMEEFLSRTMTAAASY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0I0</accession>
    <name>A0A088S0I0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 5">1-alkyl-2-acetylglycerophosphocholine esterase</fullName>
            <ecNumber evidence="1 5">3.1.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_342870</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30909"/>
            <dbReference type="ChEBI" id="CHEBI:36707"/>
            <dbReference type="EC" id="3.1.1.47"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.1.47" evidence="1 5"/>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702713.1">
        <property type="nucleotide sequence ID" value="XM_010704411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0I0"/>
    <dbReference type="GeneID" id="22578792"/>
    <dbReference type="KEGG" id="lpan:LPMP_342870"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340035000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_342870"/>
    <dbReference type="eggNOG" id="KOG3847">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000584">
        <property type="entry name" value="1-alkyl-2-acetylglycerophosphocholine esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016715">
        <property type="entry name" value="PAF_acetylhydro_eukaryote"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272:SF0">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018169">
        <property type="entry name" value="PAF_acetylhydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR018169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO01913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="453" mass="49893" checksum="4270564E0DDF2A54" modified="2014-11-26" version="1">MPPISDYILSIHYFPAGSSALLSCLALTLGVPWKTSLMVTFVGALMSCLAFYVQPLKCFTPLGGRFNVGVREVRGERGAMKPPVTVVYPTTCGTPRGGIEYFPFGERGYLVGLARYAKLPYILVKDICLLRTKMRPNAEPAPLFQRNGAPRPMVVFSHGLGGFPHLYSTLLMDFAVRGAVVFAMTHMDGSAAYCRDAGGDIRIPLNTQVGWTTEDRAPQLEVRIRETFNTMKRIWSGELLLALGYDQATVDKYVSMAPSIHLVGHSFGGATCLAAALGDTQDTNEANRVSGIASVVVYDPWMVPLLKKMFYDKLTNKEHPRHFITPTLQIFSEEWMRDKEQYSFFVKVKAIVEAQERTAEEAALVAAADAKLNELKLSWYTIKDYCCTGHSTCTDVPLISPVLYRSSYMTASPRGSIVGIAADTLQLIEKLSGPLPLDTKILNNPELAAVLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0U7</accession>
    <name>A0A088S0U7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Carboxylase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_010050</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP009370">
        <property type="protein sequence ID" value="AIN95106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696648.1">
        <property type="nucleotide sequence ID" value="XM_010698346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0U7"/>
    <dbReference type="GeneID" id="22571734"/>
    <dbReference type="KEGG" id="lpan:LPMP_010050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000031200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_010050"/>
    <dbReference type="eggNOG" id="KOG0238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000028">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000010">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050856">
        <property type="entry name" value="Biotin_carboxylase_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041265">
        <property type="entry name" value="PCC_BT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006367">
        <property type="entry name" value="PRK08591.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866">
        <property type="entry name" value="CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866:SF33">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18140">
        <property type="entry name" value="PCC_BT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0092">Biotin</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="10">
        <location>
            <begin position="5"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="9">
        <location>
            <begin position="124"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="8">
        <location>
            <begin position="590"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN95106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="665" mass="73930" checksum="5682C55626A47D08" modified="2014-11-26" version="1">MPAPIFDKVLVANRGEIACRVMATCQRLGIKTVAVYSTADEQAKHVKMADEAVCIGPPASVESYLRIDKIVDACKRTGAQAVHPGYGFLSENGELQSALQKNNIVFVGPDAHSIEAMGDKIESKRLARDAGVTCIPGFIGEVRTHEDVLRFAREVGYPVMIKASGGGGGKGMRVAYNDEQCVEYYDMCKEEAKAAFNNDKMLVEKFIENPRHIEIQVIADRKGNTLYLPERECSIQRRNQKVIEEAPSVLLDAKTRKAMGEEAVAMARAVQYVSAGTVENVVNPQKQFYFLEMNTRLQVEHPITEEITGIDLVEQMLRAAADLPLSITQDDIKINGHATECRVYAEDPTKNYFPSIGRLTKYQEPTGPGVRCDSGIMEGSQISVYYDPLICKLSTWGKDRTECIERMEKALDEYVIRGLRHNICLLRDVVTEPRYQSGHLTTNYLPEQYPDGFKKAALTAAETQLMYEAAACAHLKRERTHYTQGTAPSERQFYVSISAKQEGEVPVYVRQLDDSHFEVAASKNSPFKKLEVAWKVSYPIIRVNDGTKETVLQFWGTNEVAYSIQMKGTTFDVNVMSDLQSVLSHFVPVAETVVNTKQVLSPMPGVIVAIKVQPGQKVVAGEEILTLEAMKMRNKIHTQADGKVKGVRISLGATVEESEVLVELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S160</accession>
    <name>A0A088S160_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromosome passenger complex (CPC) protein INCENP N terminal</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_343820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702804.1">
        <property type="nucleotide sequence ID" value="XM_010704502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S160"/>
    <dbReference type="GeneID" id="22578887"/>
    <dbReference type="KEGG" id="lpan:LPMP_343820"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340045500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_343820"/>
    <dbReference type="eggNOG" id="ENOG502QWAK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268393at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO02004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="604" mass="73063" checksum="8953512C118E35DA" modified="2014-11-26" version="1">MLRRTALARRYPFNKRGPRERKSWKHHVLTEPPKPVEWRDPKVWTKDLSQMKSFDAPQWDLWLNRSRSQDMDEALQPFMDMPQSLKDRRYDIPWWANPFGAWYLQNVLSVELMKLPGRTNAEKIAIYRGRKHPATWDKSKEGLMDDEVLLKQIVKERWRTLEFGDRDAGYPCTFSDYIQFLNEWFKSLDEEGLQRLREHFDRKIRPLLAVMTHVDLMWLEALTQNSVQNKEQLERRIGFQTSLGTPEFFDMSKRLRYEINEDYKVRDELGPELFALWSKAPERWPPERLAKMYGLDFTLVRKILVWHHFKACYDACVEPDWTLPKRLFALEWIRDVRARKQGLFYGKLRFAEQKITFYSDKFLFRDLVNRREASYANVWEMDDPYRFLQTEQDYEDYWGDNYDVYRRMFPEMIGKTGEPVQQYSQMPVWAGPHRDHANKSEHNWMFAEIGVNVGHEPLKKLELDPTNEKRRRFVIRQPDGSLRSAKMSEMRAWYWKEEWADFRFWAPHMEWGVENTPSLEQYQEHVPDTPDADYRKQRRIQSRPVKWFYESHYSRSGNFAGFQPLRFMQRRTQREVRWPDVINAAVQIEKSKPSSYVFKAIPEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1B8</accession>
    <name>A0A088S1B8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RIIa domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_343940</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ropporin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702816.1">
        <property type="nucleotide sequence ID" value="XM_010704514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1B8"/>
    <dbReference type="GeneID" id="22578899"/>
    <dbReference type="KEGG" id="lpan:LPMP_343940"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340046700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_343940"/>
    <dbReference type="eggNOG" id="ENOG502RXN3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22984">
        <property type="entry name" value="DD_CrRSP7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003117">
        <property type="entry name" value="cAMP_dep_PK_reg_su_I/II_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14952:SF19">
        <property type="entry name" value="RIIA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14952">
        <property type="entry name" value="ROPPORIN-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02197">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00394">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47391">
        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIIa" evidence="5">
        <location>
            <begin position="23"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO02016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="279" mass="31850" checksum="75A29100B3E09980" modified="2014-11-26" version="1">MSTETFRERTLATQYQPRQHLPPNFSDVLKEYAREVLRNQPPDILEWSAAYFKKLALETDPLQAKQPPPDHYTPLVEDPERAMLANKMVKVFSTMDLSGSGRLPVLEVRRVLTEAFELTGSQALYLLTAPFTTIIEDDGSGLTDGGIEYTLFSHSAVRTIQYFQQHPNFFFDVDGSDANTTVHGMNRYDIEQGFLRIFRLLDEAGTGRLLLHDYQGALENAPYHLTHRDICVLRLECRTCGNDGNGGPREVEYERELPHMFERLLLAEAFSLFEEEGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1F5</accession>
    <name>A0A088S1F5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Elongation factor G, mitochondrial</fullName>
            <shortName evidence="7">EF-Gmt</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Elongation factor G 1, mitochondrial</fullName>
            <shortName evidence="7">mEF-G 1</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Elongation factor G1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MEFG</name>
        <name evidence="9" type="ORF">LPMP_350590</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702998.1">
        <property type="nucleotide sequence ID" value="XM_010704696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1F5"/>
    <dbReference type="GeneID" id="22579088"/>
    <dbReference type="KEGG" id="lpan:LPMP_350590"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350011000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_350590"/>
    <dbReference type="eggNOG" id="KOG0465">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="198619at2759"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01886">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000001">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000175">
        <property type="entry name" value="Elongation factor G, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002295">
        <property type="entry name" value="Elongation factor G, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636">
        <property type="entry name" value="ELONGATION FACTOR G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636:SF2">
        <property type="entry name" value="ELONGATION FACTOR G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="8">
        <location>
            <begin position="27"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="103"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="157"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIO02198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="746" mass="84290" checksum="FE6304EF19B83012" modified="2014-11-26" version="1">MRRSALAYVLRSSIPLLATPAFLEYVKHMRNIGISAHIDSGKTTLSERILFYSGRIGKIHEVKGGTEVGATMDSMELEKERGITIRSAATQCRWKSSTINIIDTPGHVDFTIEVERALRVLDGAILLMCAVGGVQSQTLTVDRQMKRYGVPRICFINKLDRDNANPQRALKQAQERLGINAFFIQLNMGIAQDFEGVVDLIDEKAIYFDGPFGETIRYEPVPSYIKEDVNAARKELVSRLAECDEEMESIFLNDQEPTAAQIHAAIRRATIANKFVPVMVGSAYRNKGVQLLLDAVERYLPSPEERHNSGYRVKRVKDEDGNVSNVKDGEVALLTDDEKPLVALVFKIEETKKSGLSNYVRVYQGKMRKEHLMNIRTGKNFLPPKLVRMHADSAEVVDEVRAGDICAIQGEVDASSGDTLMKAGPQAGSQLFSCEDMYVPPRVISASLRTKDDKEHSRVRERMLAFMREDPTFVYYRNSETNEDIVEGMGELHLDIYVERLKREYGLQVELGKPTVNYREIITKRQEFDFVFKRQSGGAGQWAHLKGYVEPLPIDMSVEKGVKNKATTRCSNGDIRESLQKTVVKQLERKIFVKGELMHAPVWGVHFHLSGGAMHEVDSNDQAFKNATQELWETLLLRLKPTLVEPFMDVEMTVPATNMTDVATEFSKREGVVTETTVNGPDAVIRGETALDTMFGFISDLRRLTKGQGDFSMQFKEYRPMQQYKAQMRMDERNSDLGRKSFKLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1M3</accession>
    <name>A0A088S1M3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Translation elongation factor 1-beta, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_351460</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the EF-1-beta/EF-1-delta family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703083.1">
        <property type="nucleotide sequence ID" value="XM_010704781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1M3"/>
    <dbReference type="GeneID" id="22579175"/>
    <dbReference type="KEGG" id="lpan:LPMP_351460"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350020400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_351460"/>
    <dbReference type="eggNOG" id="KOG1668">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="331763at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005853">
        <property type="term" value="C:eukaryotic translation elongation factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00292">
        <property type="entry name" value="EF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.60:FF:000001">
        <property type="entry name" value="Elongation factor 1-beta 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036219">
        <property type="entry name" value="eEF-1beta-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049720">
        <property type="entry name" value="EF1B_bsu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014038">
        <property type="entry name" value="EF1B_bsu/dsu_GNE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001326">
        <property type="entry name" value="Transl_elong_EF1B_B/D_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595">
        <property type="entry name" value="EF-HAND AND COILED-COIL DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595:SF21">
        <property type="entry name" value="ELONGATION FACTOR 1-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00736">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00888">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54984">
        <property type="entry name" value="eEF-1beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00825">
        <property type="entry name" value="EF1BD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 6" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange" evidence="5">
        <location>
            <begin position="120"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO02283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="206" mass="22681" checksum="E07F71EC7D1C4D71" modified="2014-11-26" version="1">MSTLKEINGRLNSQPFVSGFSPSSEDARIFGEMFGSNSNVIQWVARMASYYQAERDEMISSGSEKLAEPAKKVAAPAPAAADDDGIDLFGETTEEEQAALEAKKAKDAVKKKAKKDVIAKSSILFDIKAWDDTVDLEALAQKLHAIQRDGLIWGDHKLVPVAFGVKKLQQLIVIEDDKVSGDDLEDMIMSFEDEVQSMDIVAWNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1U8</accession>
    <name>A0A088S1U8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_350160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702956.1">
        <property type="nucleotide sequence ID" value="XM_010704654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1U8"/>
    <dbReference type="GeneID" id="22579045"/>
    <dbReference type="KEGG" id="lpan:LPMP_350160"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350006500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_350160"/>
    <dbReference type="eggNOG" id="ENOG502SI8U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271989at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839192" description="Transmembrane protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="31597" checksum="8C568335E99712E7" modified="2014-11-26" version="1">MLQFLASACILFLVLLCVTTVRGIGELQYGTWDVSTLLPGRGAVQPNYELTVQPEKWTVRERDAGRIGRFFDYAAARVGLVYAGVPSSEHAVCRMPPSLALKLAAVRTDDGIRLECQTVWFSAFALRSFEMDGLLHRRFDPAEPLYSAENGSCLSTPWRVQELFVARMGEGVLLLTGVLVGGTSDTREPCNVYLEVRHRPISSAKDLSSANAYAPVTMLLVVVAVRLLPRYILTRRGQLDKTSYRGKNPANLTPAQRLQLLRQQKEIIEKMKAEDRANAARGTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1V8</accession>
    <name>A0A088S1V8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_350770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703014.1">
        <property type="nucleotide sequence ID" value="XM_010704712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1V8"/>
    <dbReference type="GeneID" id="22579106"/>
    <dbReference type="KEGG" id="lpan:LPMP_350770"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350013300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_350770"/>
    <dbReference type="eggNOG" id="ENOG502SJPH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277017at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37562:SF2">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37562">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="464"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="464"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO02214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="528" mass="59809" checksum="A79FFA315049A0A8" modified="2014-11-26" version="1">MFSMDIANSGNQQMVYRNNQPPQQRQQHLQHQQQQLPQHQMFSPQYGYQQQQPYLAYPSIASPNPGKGAMNFIPSQQYMPQQQMFPYGYPQQHQAPLNQQFFPSMMTPPTQPPPPLVRYNQQGNNNSTNQCVGSHASGHSRYHGGRGRGGIHGGYGGQLHRQVHNSYFYNQQHHYSSNNAVPEKTPTVHIIHPETKKVLSVKLNRIYSTMADIRPQLQHQQSHSNSASVSNNTSVMNESKLEKAHKNEKPKEKADSSAVHKFDPKTTKLVLCLSFLSPKGCMHGSGCDKVHIAGLEYTWPQVEAKEVNKDGKKAYAAGFFVHCYDPTLTRYYKVPSGSVYVTKGSADYVSMFNDHGDNFKMKFKLCALTLERAECDKAEECEDIHCSIADLEVVRENSANATHINNPEAMADVPRLPSDMTVRVFNQNSFDTWRDYPGSNLLITEGAKAYQKQYEQEMNSVPTRKRMQHCAHFRLKDMCRLGESCRFLHVLPTEQEIKERKETEVAEAAVQAAAKGKEEVGDEANTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S254</accession>
    <name>A0A088S254_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_353460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703283.1">
        <property type="nucleotide sequence ID" value="XM_010704981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S254"/>
    <dbReference type="GeneID" id="22579375"/>
    <dbReference type="KEGG" id="lpan:LPMP_353460"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350042600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_353460"/>
    <dbReference type="eggNOG" id="ENOG502S5I5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="249894at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40736:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO02483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="138" mass="15214" checksum="959C37BEB4D26EC5" modified="2014-11-26" version="1">MFRRSSSVMRRAASVFLKEPGQAKPFQETLAACKAENRDLASMLSSDFLLLQSKLFKYRIARLGEETRYVMKHPLDCFPSANMMLVHLITLPVVFFSALCIGRGSNRPLVKPPVAETEEAAAGRAPVAAAAGDQKDQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2C7</accession>
    <name>A0A088S2C7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_352770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703214.1">
        <property type="nucleotide sequence ID" value="XM_010704912.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22579306"/>
    <dbReference type="KEGG" id="lpan:LPMP_352770"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350034900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_352770"/>
    <dbReference type="eggNOG" id="ENOG502RXBY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276888at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="605"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1403"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1403"/>
            <end position="1413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1442" mass="167347" checksum="7081215D9713B247" modified="2014-11-26" version="1">MMRRARSGSSTRCLSLSYKGCIGYPTQWSSLRHQSQNSLGGSRDRQRGQPNADPNTGSQISVVESPDLTPHLQFGLNNLEHVKLPDMSDEARRRSDIDKEREMRAKFGQYGPGERLTKSSPQMRRDMLEEQQDIDGLPWEVRWRKSLIPTSEEVIQDIRDRFDLFIQDPIEREQEWYLHWKDRSFKIQKDRMIWPQGYTDYLDHYDENGRRRVLPTDQRWSDSSWKHLADTRYKDRMWLIEGEERKAVHQSLQTDWALLKEEEQRQSEMADVYHGILSGVVDLDPDQTYQALSGTADPLEVAKTKMKLQAYGAHQALTAGKGELNPAQIDPISGFPKADMEPLPTGITVEQGAAIATQACIQYEMLEQGAEASRQAGHDPVVAAVKAHHTTSKQYGDRPMLRAQVEANIKKVKELEAERQMLEPGKTTRALTDGETVGKIEALLLAEAAEVQPAVSQTHLKASATPAESVPGAVEVSTSAGFIHITERPQNAEPDVPSELFRVPHSRELNEMPKWYRETLVETEPMIRQYSMVHDPLEEKQPEKEYYLPPPLRDSDRVTLDDAPSGESAFDEMKMHKLKSLPELVAGYKPLPLFREVAKDGSLEGATEAQEKEMKEKKLVNKDGEPLKKSQRQRLERQERLRKSKLSYDSDILLPNLPWETDSIVDPYRGVDAVDAVKFDKEDLEKTWRAYRDAFQQALTEFGNLTQVTSEDKCEKMLYDTMERFREGSIGDHPDVPKEQEEVFRLIFEAHTKHFLADFYKFKGNRTTEANTVKAEADEILRRASAKSKLLGRNFMNFVEEMTSLELDTIRKNPVQRYAIMVRDRKYEPLSQPFMRWIKNELGEFIITEFQSAEQLETHKEFLHRHLNDAYVRCPSRVDGIKDSSRDAAVEAFYQWCRGALAFYAGKKFHRMYIDFADSRFRSRAEELFEDSIELFSNYAKASKDIVQIPVPDSDPPYEYDEKEFLDGENAVFAEITGHLDKAEALWHSGSSKRWYPLTDETEYMWFNERRGRLTLATDISDRCLENVNKKTHPSIHPFPERARVFLEGAPLTQETAEHLWLRYMGDLYWEHSEFMQRQGRFQTSWSYREKCLNLYHLAVRTARERLPASWKAPLLTEAKYMLRVYEPGDHVLRHLQDVETVVDKLFAQGEPRHWIEPFSELPYRVAVVHANLPAYGEAITKEVHRRLKWQPSNELLLKDMELRARGGSVTPQLIPYYNTLNAAAETLFRRKILKWRAKEHEGSDPFLFWTHMYFAFRVHPKDRDEVQRMWDMYEPAYVYIYTQCALASRIRGHRLINDALRRLCQILLAGDRAQKLTLMEELTKVREKMAHLIDRRELDRTINALEAHLEDPAQQAYTYGTSLLYKEAMLHEKVARNPLLRTQMAAKEYTEMRKRQEELRVNGTTMNPQQAARMQEKEGGLDDESLDAQPSLTTKEMFAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S301</accession>
    <name>A0A088S301_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_080370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="AIN95846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704168.1">
        <property type="nucleotide sequence ID" value="XM_010705866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S301"/>
    <dbReference type="GeneID" id="22572499"/>
    <dbReference type="KEGG" id="lpan:LPMP_080370"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_080008600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_080370"/>
    <dbReference type="eggNOG" id="ENOG502SGW2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273825at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="576" mass="60180" checksum="3C428573471B131B" modified="2014-11-26" version="1">MTTTTQYTRSTILAWANDVLETSYTTFQDIPSHEVGLLLYGIFLGSTSRGNATASGLEDAAATATSASVPLLTEAQLHTHHQRHKATCMRYLQLLQFPSTPSPTTPANTAPPVAAAITWTTAEASASSPGRTSASALPLFPDGHHVVTSAVAQQRNAEHVLALIRALSAEEAELLRAEANDSPARGGGSTANAVLLLGSSMTPEAWLSGGAFVEELKLWRWVRLMAERHRISPRAIRRTIRAYLQHEGGSVVSVVPAPAKEAHTSPPSCAQSRGASPAPQSPTFVSEMRNVAEVALGEVRGGPLPSKSTQALPEEVSGNPAFQEIKRMRPEMLPSTSPPPANPAAATTAAITGPAMLSLTPLVGPVSPAHVLFSPIKEVAATEDGAGPDDCNATSLSWAIPGSSLHSPSTAAITSYVAQATELQAALRSAQVALENELTLHRAQQQQQPLRLPTCASGSTSPRSSGGDMLDGAGAVRKVAQLLAPATNPSDAQESLCRQHMVNTVFAKTLGGRGDSSLSSPVPDALTCDVCPSIMAHAIQCNLTAIDDLENVRARAIAACLKKDPVTLLATLQSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S307</accession>
    <name>A0A088S307_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_343390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01965.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702765.1">
        <property type="nucleotide sequence ID" value="XM_010704463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S307"/>
    <dbReference type="GeneID" id="22578844"/>
    <dbReference type="KEGG" id="lpan:LPMP_343390"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340040400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_343390"/>
    <dbReference type="eggNOG" id="ENOG502SJEG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266922at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO01965.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="428" mass="45420" checksum="21EE1EE20FE5731C" modified="2026-01-28" version="2">MSVRSRNTAKAAEARASISTARATGGLMDPTTAVYVRQHYLASTTHSVAQVLCDMEGDLLRHPRQCRTGELAAPEAMRASVDTTLPLQLLLSSFTTTSLSANPGGESKISSKLASSSLPAQDAAGSERATAAASQAAASDLSHCLRPVDAVFASKDDAAKADICRCIALHCERALTGLGLVESWGGRLRWAHVAPDGDGGGERLGVALALDAFRCWQRVVLPLLQRIRDPASRGLTADTATAETLFDYLVKRPAAVAVPRSDASSPLAPAFTCEEAAYWCFALLRGYCQDFPETVWTSILRAAQDAAAQQSSSNAVCLPPLPGEALLLRSFIAHLACSETNTACVTSAPALGQAKCGAIIASHMSSAVAAARARAEFWVWVEVELLQRTFADTKVSDSSLSALLCADGYWAVLMQPYTAMLAQYYMWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3C0</accession>
    <name>A0A088S3C0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_355940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703524.1">
        <property type="nucleotide sequence ID" value="XM_010705222.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22579622"/>
    <dbReference type="KEGG" id="lpan:LPMP_355940"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350067900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_355940"/>
    <dbReference type="eggNOG" id="ENOG502RCRT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="278628at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="CDD" id="cd23515">
        <property type="entry name" value="MPSS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="826"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="842"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1864" mass="205508" checksum="6595FD2FBE0F1E24" modified="2014-11-26" version="1">MALLRTAYLLVGASRLPLILLFSPPLRQSSSLFQTDAQQILNPSAIGHQLRDSVPPISRRRNDAAPVSSAKQRDVKRRGFNAIIRWCAYHQDTERLGLMHGGNLTGEIAGMDSSVLRWVQESIDSFSCGQCLVLLSFLCDVLDRQRKVAGGNAPTETVPSEFIRGLCRCISLLTAHTTCSEQLKIQPFLILLSAAYGLHRVTHNNPLKLPSETLETLSAPPALWLALVHQVNLYCSTTAQEHSSILESTAIEALLTTLLLFDPLRCQQFLAAPDLSLIATVTRRLDALIVPVLKATRQECKPAPSGAAPGVAHLKPGVSPEAQLPSGLEEYVTSSNTTASLSASLVPMPSRVCMSDFARIISNARTAPPACRVNLMEYLLCVLRHPSTFSIEENRYLPAIMSAVRSRNLCRMSGVPDDIIKHSTTMEFDVLAEVLCYTKRRSLYRDNIYQMLRSRFQRDDGTDVLAESQLAPNVALSLLLSLGLQLPWSLCRQLLLYSLTVAPEVLRKMQTTAKGGEENDATLRRAENSPSSKVPLSLDLCAILYFLGKCHQSLNSAQHLEQAIPEAGTEINQMIRALVCSIDWKGCTVKNLGESTRSKGNFILVGVAALGALSAYVDGYFMHQCLSDDDTMDERVLFSVLVLPILKDRTPQRVKMESLPILAKAVGLFTTEEAKRRLVTHMIRLISDGHFYSFFAFVRFVAPLAIEFKATTSEHIALVFRQRVLSVRGIPEHILRHADALKVQTTMLLRTVRYVIAIGALDSGNTAVNAARRESVRVWFEHYLQCLATTEKSSKNTALTTDSAPQAEALSSAGETSCVVNREKQTPLIAEEDNPPATDKSPEEDFEDADDAPDEHRADTNDARIALDAAFTTSVTDADVEEVLSLMLQVGCRQPYRVMLVAARRLTERASMIAEDQVSPVWCTAAPAMAGGGNRKVSTQNHAWSEPTMNSDSIATAGDEHSCPALLSVPPLAAHFVCAVRIDFAIALPSMLPTFVSALLARCDIRIFYHVVSAILMAVKRRRRVPALSEDLQIGVIAFGTLQRRLAMGHLVDSQEQSTTVLKLIVSFLHHLTLAVPHLCVAQLAFLLANSQRGTASTLVSNNRASSQLDCMAGLSKELQGVVPQDEAEPGDLDDAVDDKDVFESHVAIHAELEACLLRLVPYLGAVELKQIGLAHLQRLSLFFPHASPFVAQQLQPQLSDFSQRELLQLVAQYPAGTAEVLALLSKTDLYASIDLNDYVTIAKRLPMQINEVIVAAHLPHMTIAWIARVLSALAARHEEVPMRLLRSLLYRVSAVAEDASESDKSLLMMVLQGYLLFRSDRGTLVERLAEMKSAAAESSISHIDDVLWSMTLTAHKVEEGEQQERRELIRTSFDRLLSLEHISTLDALRVFLISYPTFLHQIREQGVVAKVEQQLLPNILATTPVQWRELAALVQLLAEHHVLLPSTVDILLKSVFTAAQLTSLYKAVMASSDSNTVSALETLLQIAAKCAEAAAPGHSPFPLLPVTELVLSIFNAVQHWLAAVTGLLVTTTSSLSASEETTGRHICWMLLNRSDELKPSEFARLVQSMSRLKAWDLMAIESKPSPAGTATAAAGESLAFDRALASCYERADAHSRCILLKAIAMDTSVLRRFETIVFPPIQNDVPLLPSEDLELVLTAVLQVSNEAIVEPVLDAIDTRMLPILDQCRRSAIVRLVQCHAHFSINDEIVVTAALQALERQATTEVKLDVSQLLSILQAVASLTVSQLPERLLVLCFQRLEKMASMLTPLQQYQVGRLILDLEMGYSSSVSALVLHILDSRDGVRGHKQFQAMTEELCDVFEVELPAQLRACRLRKVRNKQRVKDFWSAQRRLKQQAMLHHCQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3C7</accession>
    <name>A0A088S3C7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_355200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703451.1">
        <property type="nucleotide sequence ID" value="XM_010705149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3C7"/>
    <dbReference type="GeneID" id="22579548"/>
    <dbReference type="KEGG" id="lpan:LPMP_355200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350060500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_355200"/>
    <dbReference type="eggNOG" id="ENOG502RXTB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272920at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="620" mass="66954" checksum="AB3671A1D17AE511" modified="2014-11-26" version="1">MPSRNLMEPSTSSISGLAGDASSSRGTDRGGRSTFRGGRGSSDRRGRGHVFSHGSNDAFRGRGRCRGSACWRSRGDGQREGRGFVSRKFRRHRSLSGKRGSYKPGEGEAMVKREKKDQKPNSNFALLYSMLGDAATIAEYIRDYHSSEKFRDAKSVNTFLQAVSQRPKVVYEELMSHYKDEVFTALERLFALYALGKTPITPPAHEFLIRCEQEGVRKSGWSEGVRTLPANTAEAGTTVSAKGDAEGVAPPPPPPAPVALPMDTEAASLLSPRELLSNLASLDAVGRLQRLIEMARTVDDIQVCAKKLTNVLTDAQNDVQNGNQLSRTSAEKFDYAAKCQLISKLLSKARRVVEPAFALPPKATTKGTSGDHVDELAGEATARQEQQVPGGDGDAVLSQTTTETTSSAASGTGVATATPVVAQRRDPLTKSEIAGFQVAISVAFHALETVLTQRLPSVTQQPLSKFAKMLEWCKERSLLAAEDERFATLLEQQAEKGIAEQANQIETVINIKSLAAGDTDALREVVNQLWEAGGTKCLSPSSQDVLSAIAVAASVEGIAADVKRMVADRLLQTQCHLTDAIVLPRRALRFVNGERNKVKQAAIAKQLLEEAGKDKTEHDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3D1</accession>
    <name>A0A088S3D1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_355250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703456.1">
        <property type="nucleotide sequence ID" value="XM_010705154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3D1"/>
    <dbReference type="GeneID" id="22579553"/>
    <dbReference type="KEGG" id="lpan:LPMP_355250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350061000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_355250"/>
    <dbReference type="eggNOG" id="ENOG502S1G4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270586at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO02656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="278" mass="30283" checksum="50197DF9304F8296" modified="2014-11-26" version="1">MSAPPSYEDLAKVVRDYLMKGSDVTGWHLDAKEDVVPNRLNAYPFASPNAIGVHLFYECPDCHTTVKSRVSAAFKSWREYLPTIIYQTKLNDVSEKIEVDAAAATVKVAAEHPVFNASCKTLLLDGFTTNANVATRVSNQLFAGASLQYDPKRSGVRDFTAIMVRYACPNIRNGDLLGKYSLQNGFSVHLRVPLHTYIDAAVVAERRCFIAGVQGCSPCGARIMLNANVSDGTYTATAIRNLNDIWKVTATLTAPFASGDGCAAPRFGLKFTNMNASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3G7</accession>
    <name>A0A088S3G7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_356510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02779.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703579.1">
        <property type="nucleotide sequence ID" value="XM_010705277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3G7"/>
    <dbReference type="GeneID" id="22579679"/>
    <dbReference type="KEGG" id="lpan:LPMP_356510"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_356510"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO02779.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="110" mass="11586" checksum="C4C3626895A4CE32" modified="2026-01-28" version="2">MMEGFSRFCSLKGAREVHRKRFAMPGVETLQVLHTVAVWQGTEASAVTQGSFDRPIPARVSGGSHVRGDSAHEAHGTGRPADDGGKHFKVAGQGGLTADRDSGQSTGRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3R8</accession>
    <name>A0A088S3R8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_357140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703641.1">
        <property type="nucleotide sequence ID" value="XM_010705339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3R8"/>
    <dbReference type="GeneID" id="22579742"/>
    <dbReference type="KEGG" id="lpan:LPMP_357140"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350081100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_357140"/>
    <dbReference type="eggNOG" id="ENOG502S52M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269021at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO02841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="135" mass="14548" checksum="8B57FC92B1D8FE8B" modified="2014-11-26" version="1">MRLSKLLLQGSAPASLIGDLSIHACVGVIQSPSRGMLQGEPEWSCKLLLTECGSPAQWPPALRTVATQQVFRLRCRGAAMAGYCFANLKEGELVHVVSKLVHKPRYITVHGTYFTATELLVTDSLGSIVSVAQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S464</accession>
    <name>A0A088S464_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fanconi-associated nuclease</fullName>
            <ecNumber evidence="5">3.1.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_352680</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.</text>
            <dbReference type="EC" id="3.1.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FAN1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.1" evidence="5"/>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703205.1">
        <property type="nucleotide sequence ID" value="XM_010704903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22579297"/>
    <dbReference type="KEGG" id="lpan:LPMP_352680"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350033900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_352680"/>
    <dbReference type="eggNOG" id="ENOG502RYXS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="76364at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070336">
        <property type="term" value="F:flap-structured DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004528">
        <property type="term" value="F:phosphodiesterase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033315">
        <property type="entry name" value="Fan1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014883">
        <property type="entry name" value="VRR_NUC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15749">
        <property type="entry name" value="FANCONI-ASSOCIATED NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15749:SF4">
        <property type="entry name" value="FANCONI-ASSOCIATED NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08774">
        <property type="entry name" value="VRR_NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VRR-NUC" evidence="7">
        <location>
            <begin position="1656"/>
            <end position="1731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="63"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="787"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1333"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1476"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1487"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1515"/>
            <end position="1530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO02405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1746" mass="188953" checksum="ED1BA37C0E531336" modified="2014-11-26" version="1">MSADADATPTDPFLKPRRSPKTSRSSAINDSAMLVEVVDAGQTTSSSSVAAAALFAARLRPSVTVATGASTSPRDTLTPLASSAATSRGAAAIMPHTRKRKRPAAESASAGSSTSTTAAPPLAQKRQEAAQRKSEPSRRTGGAARTAMDHGQHSKYSSDEDALGGATVAGGGDDAEGYGSGEDGEGDAEERALVATASSLMAGQGAFATTSAVSATPHPWLVTDAFHVCLWYVLRYAGSALSAEDLWSCRALVSLTAVEATEKAHAGECGLLKGAISGTAGAERMTAAFAAERAPGTSMQSDGWDWTGSEESELLLRLLLRKSHSFTARHLELRYGDWLHVQSALNALTQRRFLWWATKGASLDSAADGVGTVPLHGAEEEAATDLTETPLTPDDELTEMAPSQLVKHYDGARVARLLLNSCDEGRTQCSHAAAIGESMPTFGSMEAVIRVAQAVRVTEFRTFLTMLRHRSKARAAMDESAQEGDECITTSSIISTSASTLGISENIVCKDGGAGRDVVAEQASVLRLKSCGRAADIACARPRQMSDNSLYDVIPGRKRDMIRYLVERRYSVWAPSSTVKGSPEVSATPNTVAMDTTVPSYDAPCTAPHALCSAPLIASPALRGAVRCTSASVGATSRPLFRRCFRTVAEEADAVAQCWDRVIGSVYVPHSGLKQHLTWMTELFHVLSSNHGAGMMSEKGAKSVVATMTVATPPTLLMTRPQLLLLLQTLRAARRQERPSLPESSLSTAAHLNSNVFAESVPYALLPRWFSPPPVAKATRAVPRPCRQLDRGIPSNGGAGNTMESQPCPDVSVEPNDDESNAMDDIVYTTHLFRAFGAAGDDVAAQTFATPPRVRLFASPAILQEYRRALSIQRKLYYATDGATTAAQRHRGKSRTFVSCMYDTVMAAVHAGVAAVKQHPLHARSASSASFVSGEMRHFVSMYPPALPVVSDTAPSPKLSTPSVTVSLESLVYQQGCYAEHLLTFTPLYRWFACLELLFPLLQSGQRYSDANACLHHLLYEPIFVLHHLPVSGSRSPISPVTYAFCFKPHKRGKWLARMAQNLSHQKRYAEALAVLEECQAGYHELASHAMGDARLAPAAAAVGNGVYVASAKWLPCDVMTNSTAAALCDVLMGNRSPTSESALPLKVQRRGRMLRVLWGAAAAASVLPAANNSTTSLPQAEKPSPVSLALLHAAWEYVRDRYCRRQDRLTLERLLAVVHRKVHQWTSLAAHRDLATRSLVDVAVRHVGGVRDALNRILWREPSVQAHGLTTTSTGGVVRAAKSMTPSEVRNPQHHPALPVELFVLQHYLNRWNGASSTTATAAGLATVPQHRRRNDTMATDPPKGETERSDGIGDVKVASMWCGEHCEGQWIACFARAFLWDCYWSFPPVFFPLDGFPVNACDHKSNRPPLQTCPTHGVLWLSAFQDGPLDLATPIQFLWRRRALVEARLAKLERCTREELVDFVAARIKVAGNTEGARPSKARARGRDTEVEAPRAEDDVVQRADEDEGYSGDEERERHRHSRDEGGRSPRRPRYTARVEERCCVSNDENSVRIASSFSATPLLFTEFTTPSLLLGQVGREASAEMERVGLMRESGDASLSSCSSTLAIPEAWKVPVGSLPLLDILRAIPLEPLWRLLRCLYLSPVTEGVPLEFSGFPDLVFWRTGGCGGGNYRYAAIQPSAEESSTVLRASFCLMEVKSPNDCLSTKQIAVNDLLRRCGFEVFVVHVDEVHDDGRRVSTKCIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S4K8</accession>
    <name>A0A088S4K8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_120940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009381">
        <property type="protein sequence ID" value="AIN96421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697074.1">
        <property type="nucleotide sequence ID" value="XM_010698772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S4K8"/>
    <dbReference type="GeneID" id="22573100"/>
    <dbReference type="KEGG" id="lpan:LPMP_120940"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_120014400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_120940"/>
    <dbReference type="eggNOG" id="ENOG502RZBW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271917at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37561">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37561:SF3">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="475" mass="52759" checksum="4226C03D6A9088E8" modified="2014-11-26" version="1">MLHLASEPQRKKGPAVPEYSRFLFGLALLLTILSDSSMNSHFAELSTIITANSDPSALQQLATFAAMEDVAEEEHLDWGSTSRLVHAQPTSLAKPRSAVPPNPLELDSVSPRTHHRTDSDNMLSDSHRSLTGTSTDETAGKSSTASSSFSRRRPHRRHHCRRSTASGAVSDVLSNSEAAAKLSAPRPVHSYVMWTKFHVMELAYSTGSNNFVHITERFLQYQRMFPIIYRCGLSKVDCPYEADLLAFPKVGLAASSRWACESCGKKHNVVCESCLRCRTPGPYAKLLIGQVVKAVGCTESLVRFFYATHPDIMIHRAECHYDTDGGVAGGGKGCASIYIRREDAAPLQQKLHHNAFFDVDSETEELLVYYVYAEQREWLQRYVQQRISTAERRPLFLPLSPLVVKESTPCAAPARRCIGRGRGRQHQGWGCGSTSFTATPAVHQQGGSRRGEHAMRQRRYQLREPCSHESEASGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S4U2</accession>
    <name>A0A088S4U2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNaJ family chaperone protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_355090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703440.1">
        <property type="nucleotide sequence ID" value="XM_010705138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S4U2"/>
    <dbReference type="GeneID" id="22579537"/>
    <dbReference type="KEGG" id="lpan:LPMP_355090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350059400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_355090"/>
    <dbReference type="eggNOG" id="ENOG502QU69">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="244432at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="18"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO02640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="353" mass="39677" checksum="085A2839FFC1C681" modified="2014-11-26" version="1">MFSRTLCRSAPVIEDVVAAFKVLGLTYNPRAPTPSRPRVEDVRRQYREMARLHHPDLSSGDDNRMKVINTAYELIQSSGILQGTYDAPAGATDDAAGQQGGETRAATRFARKAGTRRRRMPDDFASGDDSSWAMKTSLDWQAMMNSTETITVEELKNPANHPFSHSRFFTFDDDLTIYRMIRGGATVRQVARTLGKPATFVERRLQNAQFKLRVQYVLRQDKRKAAAASSNAAVSSHSMRQTTSTPIAEPATRRALRHSPYDETHGGNAAHIFSTASMRKREWEPSYPEWRAPRYRVQMTLEEQGRLDGLLRETPRASNVTGKAVASADSARRSAASKMGRSYENYKRLRSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S533</accession>
    <name>A0A088S533_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_356310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703560.1">
        <property type="nucleotide sequence ID" value="XM_010705258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S533"/>
    <dbReference type="GeneID" id="22579659"/>
    <dbReference type="KEGG" id="lpan:LPMP_356310"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350071600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_356310"/>
    <dbReference type="eggNOG" id="ENOG502SKZH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265004at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016543">
        <property type="entry name" value="Fis1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247:SF0">
        <property type="entry name" value="MITOCHONDRIAL FISSION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 11 TPR REPEAT PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO02760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="364" mass="39172" checksum="204DD9129B6A4FB2" modified="2014-11-26" version="1">MSAASASCATRPDLAEPASLLESLQILRSENPQYMAITHPSPEQVDDLNSVIQCLRLQLDGGVDGATGDETAYELAVALLWHSDKSLIEEGVLLMEYLLKERWNHYWSTVIRRPPDTDVDDDEHGKALCSDLVESAPEEDGLDDGRPHDNEWLGISGSPSDGKSASSSSAAAAADPCSTHCTNNEMVESAENTGPSVILRGSAVQFATAPPPPEVGYGSAPPSLMRDRAQPSACRWGASGMTVASSCSSATTAAMTSTQCLPKALGVSCTSPSTAGSSTHRHSSNCEDAHPHYERLASCYYHLAVGYTKLRKNEKALFYVNNVLRLIPCSEEGQLLRRLLCARLYVQHVFIFTVPLLAVGFLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S613</accession>
    <name>A0A088S613_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_161110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN96986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697639.1">
        <property type="nucleotide sequence ID" value="XM_010699337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S613"/>
    <dbReference type="GeneID" id="22573690"/>
    <dbReference type="KEGG" id="lpan:LPMP_161110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160016500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_161110"/>
    <dbReference type="eggNOG" id="ENOG502S4Q7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273083at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="342" mass="39794" checksum="328E43A8110668D4" modified="2014-11-26" version="1">MLDEHEGREAAFGYDLKNFCATEVPDEAPHSSDDSTTVESTEETTPAGSGYFACFRRPFHRRRSVAKTAAPAVAAQSTGTTAQQLSTPTTNYGELGCKLLLWERELRHQLVRHEQEELTQMVWSVEKMLLPVMEALRYVNTLSVAQEEVVWRWTIRNDYYHFLLGVTQLQEVLHRRSLSFAEEPRDRKEIENVEVPHWIAARRLQVTRETQESAAAKEEERERRLAHFSFIQQQLYQIFLLGEEEQADRMDVERLQRLYAGSILEAMAKVYRHVRLCQLRYEAMGLELQPEVTRDLVADEALHRALLRQDQALGFKKMQADEIRNYLASSRQELLNRRVEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S7C9</accession>
    <name>A0A088S7C9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_191400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698134.1">
        <property type="nucleotide sequence ID" value="XM_010699832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S7C9"/>
    <dbReference type="GeneID" id="22574194"/>
    <dbReference type="KEGG" id="lpan:LPMP_191400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190021300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_191400"/>
    <dbReference type="eggNOG" id="ENOG502QVQF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277900at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="872" mass="97560" checksum="C29E44B1626C53E1" modified="2014-11-26" version="1">MPPGGFEDALPDSFGRHSGKGELSTVNLHSKRQNARRVKRCRRKLRVPPASSPPPTLAKVKGELLHLIQQTREAREEALSRPTEVVGMSAAEVWSPLSASRVLPTEVADSIYQGEERESRSTFHSPHTTFFGCETGDSAAAVSAASASSPVLSLAVTSSPEEAWPSHEDAMERLYAVKPTSTIFGSDLDRLERDMMREYHQRGARLPPCDRVYAEFGGSQRGRRMQWEPSSSFDHLATSDFRFDARSETVVGDSTNRNLAAYHFYAEAYQAQQEENRRLQCSRTTNSKGISLCRVDRGASVGAKTDLPASENPHFPAEGPDDAEHLRTLLSADVGAPDMALLGGVSSAPKEVVVDARTDYKSRLSIAPSLPCEGEDTNCIVYDAYHQRPTDNTLLEVRGVDYWVDDENRCRVEERSAHRQESIAREMLQEGAVDTSETEYSTNKVRKETLLYFQAHPINEMIQEPFVRIRQFMPPGGGPRVSFNPNEPLPVPPDSEYDGRSVIESVNMDVDIPVSAARRMAQELGLDLIRIGALYSQKTDRRIIALCMIGDHREHMREMIKFKIQKLGVQPPPTKECIEVPFKGGTHPHAIRFKCVGVAKHLLHRHVIRINLTKFGTPREGFPVFQSILDELKRQCMRLKAYHTAGQIQSNYDEIFCYLYPSTGRSPKATVTHPTPQEMMEARDDRILENEKEIYFDDLQDKVTRKQRLQYKLKLENGTAWAEKDEGMSLQRQRAIKVMLGYLPKGNRELYAARGDVNIPAPFRASHPTSVYKWSYPSESNLEQASRGAAALGKRAAMPISEMHDAGETPENPTQLDHFYYTAQGPALEMGEFKEALGLKDNRVRRPPMGAGFATLGVEAADEAVQTGFATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S7Z8</accession>
    <name>A0A088S7Z8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">G-actin binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_201970</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Interacts with G-actin; ADP-actin form.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698398.1">
        <property type="nucleotide sequence ID" value="XM_010700096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S7Z8"/>
    <dbReference type="GeneID" id="22574406"/>
    <dbReference type="KEGG" id="lpan:LPMP_201970"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200025100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201970"/>
    <dbReference type="eggNOG" id="ENOG502S44T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10006997at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11284">
        <property type="entry name" value="ADF_Twf-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028458">
        <property type="entry name" value="Twinfilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759:SF1">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ADF-H" evidence="9">
        <location>
            <begin position="168"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="303"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN97691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="331" mass="35837" checksum="6F1F723E78B3E8D8" modified="2014-11-26" version="1">MLQIELSIAPDAQAALEESGKQNTTTVAVLITIEKEVLHLLAPPVSFSGDGFEHDLTTTRTFLDAKSVSAAYIVVRSAPSTQHVVMYVSDSAAAKNRMLYSTGLRSMVEATPHAQKQTIQISSVNELLPSLFEAEPMNVREDLMTESERHRAAIARMVVAPQPVALPGVAIKMTPEASDMLSQFAGGAVDVATFKIEAEQLKLDQVVKQLGGDFNQVKSILTDTDPRFVLLRYPSPKTQRAEAVMVYVCPPTCSPKIKIQYASSVAAFREQALHYKIKFAHKVETDTPSTLVEDVHSAFEPFPSGAARGAQGEAPSCSSVSSAPKGHRMLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S839</accession>
    <name>A0A088S839_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_202450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698448.1">
        <property type="nucleotide sequence ID" value="XM_010700146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S839"/>
    <dbReference type="GeneID" id="22574454"/>
    <dbReference type="KEGG" id="lpan:LPMP_202450"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200029800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_202450"/>
    <dbReference type="eggNOG" id="ENOG502SITI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272754at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="282" mass="29330" checksum="7D43F9F298F1B1BD" modified="2014-11-26" version="1">MSRLSSATCPLSDCTLAVDNAENIRNSKDVSLLALKVAATAVAIPSTPRQRALLRNAKAIGCSAAAEAVTLPACRERVSGTTHSTNITASTAVVNTAAEMPPFSTNAVYRSSSLDCYLFAKPFTPASTLHRNDPYSPCLLKSTCSPEDSFYACYSEVDEALAVVAMNPANTPTRLPVVCQTAALPSETQALLELLSKTTVSSSLCMSPITAPMKMCDSAEQSPASLAAGGGLTTTPSLASTPERAASPSSRQLCAASARVIRKVVSCGVDRTSGRPVPKPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S884</accession>
    <name>A0A088S884_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytochrome p450-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_203050</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698508.1">
        <property type="nucleotide sequence ID" value="XM_010700206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S884"/>
    <dbReference type="GeneID" id="22574516"/>
    <dbReference type="KEGG" id="lpan:LPMP_203050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200036400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_203050"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="3">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN97801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="546" mass="61711" checksum="B878001C6CD2938B" modified="2014-11-26" version="1">MIPITLPVKAAAVVATVGALTYATMRALQAVYSAPPNMPEPAIPPNPEDGPLWSVVKRILYRHFYVVRKGDPLKTLQRWCTEFEYKPFVMKIFFRPHVVLSCPGDIEHVLLRADTKFYKDTGYDIVRIVVGRVGLVAVGNKEKHAMHRRILMPIFRSQNIRGLANEIIRVHALHMLGGLFDVIQCGSRQDAAVNLSDHIFRMALSAIGEAAFRASRSESLRVRTHFNAMMKMSRMNYFCPYLKSAAQRNARKILREMSVGLLDKNMQMNQIGARRCVMDALIDELYVHFSMEDVLDHVVNFLFAGHDTASHTMEFLFALLGANKEVQDRLYEALEDLMPSICTCPTVEELMECDYLVAVVKEALRMYPAAPIIYRDAAEDVYLPESRVVIPKGMTVVITLFSLQRNTHVYGDDVDVFRPERWLYEEGEALRKRCGRCGYIPFSCGKRSCIGQEFGYLELLIVTALLVRHLKMELVGKFPEARYNITLVMSHPVSMRITARDGISVSQIYERIANVLDLNDEDAESAGNAAREAGGMMGCKETTVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SBW1</accession>
    <name>A0A088SBW1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pseudouridylate synthase-like protein</fullName>
            <ecNumber evidence="3">4.2.1.70</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_260420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.2.1.70" evidence="3"/>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699863.1">
        <property type="nucleotide sequence ID" value="XM_010701561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SBW1"/>
    <dbReference type="GeneID" id="22575945"/>
    <dbReference type="KEGG" id="lpan:LPMP_260420"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260009000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_260420"/>
    <dbReference type="eggNOG" id="KOG2553">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10256309at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004730">
        <property type="term" value="F:pseudouridylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.580:FF:000036">
        <property type="entry name" value="Pseudouridylate synthase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF26">
        <property type="entry name" value="SYNTHASE I, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="570"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="570"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="689" mass="75410" checksum="F60A9157F4080396" modified="2014-11-26" version="1">MRDRGARRRPDPRRMMVGKAPKDQVHIGLCLLYSGSGFRGLQIQVHAPTCHTVEGMLIQALKDTGIIADVVRGRPAGEHHHFARSCRTDRGVHAIRNMVSLFVPKEVFDKVGQSGGICERLNRRLPATVRVASVMQLSGSFIPRHCCNRRVYRYMLPLYALLPPCDTWAAVEKYYSGCLAYVQTLAKEAVAAQRTQHGVPYVDLEKMSAAEPSADGQASQSSWLRHLQASTNRCNQLLRSHFTGSRRYHNFSVDIDSNRSGVSAKVIQPANDEALRVIYRSEVCPRLFFFPCSIQGGAGDEAPVLLHGESRKEYDMNLLRYPPPTSALMDGANGDSPVASATTVSSGSSTTPTTCLPPTTTVLPFLIFQIEGESFLLNMIRKVIGSLLAVCRGARESILEEALSPERRVTTPLAPGPYLYLAQSTYHGYDRSIGGASCSGPPGRLTRVQDAWGGAVSEAAELFAFHNIAADIVDVDLNAMPPLDDILAARDRALSASRPHTVVEDAHLIEMREYRSVLPTRTPWPVSSEMTVFLRLLRVHNWSVRPIQLDPDCKALREIRNRKERAAASSIAAAASPGAEAVEASEVDGNDTKRREATEEQAAAPIDDLSKVPSEGGGKSSVPESGEDGWVYVAGTPNEASAQRQAYFARCWKRARPWEYDDETAKSLTGGKHVRIEGDVEVGDDSVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SI60</accession>
    <name>A0A088SI60_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycerolphosphate mutase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_332210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702312.1">
        <property type="nucleotide sequence ID" value="XM_010704010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SI60"/>
    <dbReference type="GeneID" id="22578374"/>
    <dbReference type="KEGG" id="lpan:LPMP_332210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330029600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_332210"/>
    <dbReference type="eggNOG" id="ENOG502QTHF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261749at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052765">
        <property type="entry name" value="PGM-Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46192">
        <property type="entry name" value="BROAD-RANGE ACID PHOSPHATASE DET1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="393"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="431"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO01512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="501" mass="55731" checksum="764AE26AB5D1FE21" modified="2014-11-26" version="1">MWWTAARRRLSYPNQIFTSKDSRRIQHSWLPRRLLLVRHGESVANVNQEVYSNTPDWKIPLTARGREQAYDCGKRLRNIIQGEKLYIYYSPYARTRQTLCEIRRSFDESQIQGEREDERLREQEMGNYQPLNEMNATWAARHAFGRLYYRFPFGESGADVGDRVSGFFDSLLRESIGLTVPNMNECTEQCTRGDQGYQELGQCSADNDGLAGSACDFHAPLSQGGPVASSMGSGTASPSWKPPSQEAPTSSTGLRRTIWRTAPHHSLPLDDLCEPEAHGVLPPSDHRASVGDDQNVLIIAHGLLIRLFIARWFRVPMEVFETMCNPPNCAIIVLERDDRLGRLVMTDMSKCLFGSDPLLQMMRFDGCEDTHWYREKFLGIVDPTKAMEEAVAEDDDENHYSMSNAHNSGVGAPAPPPRQRKASTSMATGFSPSTSASPSCTSTSITESADALASTAGHAVLSASDCATQPMSSSPCMNCTPNCDWKFCRDTDDAPKMGSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SJR9</accession>
    <name>A0A088SJR9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_344360</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702857.1">
        <property type="nucleotide sequence ID" value="XM_010704555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SJR9"/>
    <dbReference type="GeneID" id="22578941"/>
    <dbReference type="KEGG" id="lpan:LPMP_344360"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340051500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_344360"/>
    <dbReference type="eggNOG" id="KOG1493">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1681166at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000460">
        <property type="entry name" value="Anaphase promoting complex subunit 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024991">
        <property type="entry name" value="RING-H2_APC11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12861">
        <property type="entry name" value="zf-ANAPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="34"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIO02057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="82" mass="9382" checksum="B2CD13E08EE26F30" modified="2014-11-26" version="1">MDVKIKSIHLVAKWMWDCKGETCGICRQEYEAVCPTCRVPGDDCPILTSPCHHTFHLHCITRALEKEEGQPECPTCRAPWQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SKA7</accession>
    <name>A0A088SKA7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_351050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703042.1">
        <property type="nucleotide sequence ID" value="XM_010704740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SKA7"/>
    <dbReference type="GeneID" id="22579134"/>
    <dbReference type="KEGG" id="lpan:LPMP_351050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350016100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_351050"/>
    <dbReference type="eggNOG" id="ENOG502S9PD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273175at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839464" description="Transmembrane protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="413"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="509"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO02242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="551" mass="61655" checksum="BA2350DE701F1067" modified="2014-11-26" version="1">MLIMRILVWLACVAAFGLLSLVAADTVFSHDTRSHTVTIEPGVLPEAQSFGRLRLRTGEWMYSFNPGEEASFFSSEDSASRQWLEWKAELRLLQEYRQRQHLGRYSTGGEKTDTSANQGNSEGRDPTALPIVDYFADRNVRRRHAERLRKQSLYNLSDSEEAADARVLVENEIAAMWHLVQSTGRSNGTNDQEFLGLVERYFSHTLTNRSAAAPSRFLPSLPRALLRLPLVLDAEVVPFMEREVGHVRDLWKLRLADGVAPAASSDEVESQLQLLSTTIEDSKTVATAVATLVEPLADAALSWVASSLTATREAIVMNDESTEAKRSELKRLLKQQSVLHKMRPTLEKHSKVYQGVVRRGQLPNTEATLFALQLIAKQRFGDNVSGLVEAVPSLSVTAPLTGLLEQEWRVHVLAPYGICVLATATFIWLCEELKERLLSRVRARRLCPMPRSPCGMTTSLSNCARQAYMLVSLLELVVLPLLPVIVLLIHLRGVRFWICSLIALMRPCQLTVCLASGAFLLAANYLVARVVRRVFQIVSPSVYRRRLAKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SL99</accession>
    <name>A0A088SL99_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_354500</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703382.1">
        <property type="nucleotide sequence ID" value="XM_010705080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SL99"/>
    <dbReference type="GeneID" id="22579478"/>
    <dbReference type="KEGG" id="lpan:LPMP_354500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350053200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350053300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_354500"/>
    <dbReference type="eggNOG" id="KOG2001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2192946at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1900:FF:000028">
        <property type="entry name" value="Spindle pole body component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF13">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="136"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="537"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="70"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIO02582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="873" mass="95225" checksum="675386F96CF3D276" modified="2014-11-26" version="1">MGSRPDWIRFLASLEKRGVRFDQVQYATDRQEVIRATGITDALSIAVVETEWQRRCSHGGDAADAMNLDRQGFSASNPTGARTLAPLLSPPAPREGGSTTLSRASNGGGIDLPALHDVSQLAKLPEELQDTVLATEVLAAAVGLGGMFLQHTPASPGTSNGINTKDGFHISPLVPASMRSLCETVLPIADAFVALRCIEKAEYTSRSLVLMALGEVVSEINTSYAYQVSRLQLWSEGRPMPLMGVVSEILRVGHHVVRLRQVLPMDLISTALADVATAAPSSSTFASPTTGLVGPRILNHLYDQVNKYSGSSEDHELLMLLLRRSLVPYLRMLQRWMHSGVLDDPYGEFFISETHHPARPAPTAASHQQLRHTGQLFLNALASTTPGTGRDGELGAGGSSTAFQGRFGPHRRAAAQQDVVAFDRRFSLNKSLVPVFLSTPSRIAKMVFFAGKYCCLLREYGAALPAFRVASLPGGAAGSTLSTANAAAAAATCGADGLGEAFLTWSGADQLQRQVQESFEIASGAVIQLLFSSSVDLLGHLKSLKLYFLQERGDWVVDFLDSADSLLAEYPDRVKQYSMQVLLQAAVARSCASDPYHDLIGCSFANCTLEELLQEQNRQRDSGRDATTAGVSDSATATLPFRRNMDGGGGEVEARRSLELLQLETDLQWPLTLVLDSKVTHRLNVIFRLLIWVKTCERRLCELWYTNEILGEFSAAYGLKHQFVQFLRQFQFYAAHFVLEPLWSRLIARIGQADSVFTISQALTEFFDGVETGLVLSSTQRFRSLAHILELTERFCAVGMHSSTATMPLIDATLHSVEDQFLSALSELASPIGPDYPQLVPLLTWIDFSRFYDQNNVYHVQHGAASSAAGRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SLV9</accession>
    <name>A0A088SLV9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_356790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703607.1">
        <property type="nucleotide sequence ID" value="XM_010705305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SLV9"/>
    <dbReference type="GeneID" id="22579707"/>
    <dbReference type="KEGG" id="lpan:LPMP_356790"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350077500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_356790"/>
    <dbReference type="eggNOG" id="ENOG502RXB1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="278480at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO02807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="750" mass="82904" checksum="058B62F84B44D231" modified="2014-11-26" version="1">MAYRHGSHPCHGFDELAAAPAGRQCSVCKALSDGSDVRWFGCVASPCEFLLCEKCFTVQEELLAQPQVVIRNPMLDYDDGKAAVHTRPREQSYRLSPLYAGRLLRVVSTAADVSDPSREYYRIASGGWINRSHVVCVHPHPSPSMQLLSEVHLNNRKLGSDIASGAVSISVLYDLLHECMQTIDENEAYGIVMSALVMYPLLSTLEIHCCHFRTAPDPLPLVEYVHFVLHFVLTKLVERMDMEEAQFVFKLVDGAMAFLFGDVLARCLGAAYHLAFTWKVRLPSSFAYLVSRALATMDRLLRLLPEEASEQSPALCAPAVTLIHNSRSVERQRLGRLIITMTDMGSCLLQHCIRETRLDLDVLQPLRDQLCGDHRHHLSKVFCEALATMAEVDLLRVQRTYLHLDALEVVGGLAANSCLAESQVAVFRLVKYLAKQCPHNIAMLSAVLLDKLLKMLADTQSPAVYVEAMECFYEMAFNDPRIRGADAGASEMPQPQPHACTAHTGTSGGTAEKANTPYQLLCVYRLPFGGVLMPLCSYCAMHHPPSGGDLMERPQYAYFQCHCHHCSTVVTRSALQVPQLPTIPQTTALNILEEHLSKKAFALSAYLQIPQALNALGRLLLRVALQDEVLVRVIEELVRYPSLESVPYAALVVKANAHLPAVKQCLARYANTELSRYVHGTFEVATPAKNYVDETPAKSHQRSELGLSASPYTNSTVQSGSMYDMRGVFSCSRDGARGVQLFGAGASVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4M5</accession>
    <name>A0AC62A4M5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_311370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="XUY36694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="643" mass="66708" checksum="7AEEA5FE2E430D98" modified="2026-01-28" version="1">MPRSSFRVGLIALFAAAALLFTFAAPVTRATVVSPWDTMKDHAFLDNLANGARASFALSAEERRNTLKVMQAFAAALPSLGWTGDDFCTWNGVSCFDSNVTFVAAGTAAAGTLPEMPDDVDYSKVKIDQIDIFNKKTYITGTLPSSWGKLSKVRLINLAYTSISGTLPASWASMSSLKSLALSSTGISGTLPAAWGSMPALEVLTLSTTQITGTLPEEWSTMPSVQRIHIQRGKLYGPFPASWAQMPSLERLALQTNDFCGCLPASWLSTTTLLVGVDSRHRKADCATASPCPETTTTTTMEPAPSTTTTTTMEPAPSSTTTTTMEPAPSTTTTTTMEPAPSTTTTMEPAPSTTTTTTMEPAPSSTTTTTMEPAPSTTTTTTMEPAPSTTTTTTMEPAPSTTTTMEPAPSTTTTTTMEPAPSTTTTTTMEPAPSSTTTTTMEPAPSTTTTTTMEPAPSTTTTTTMEPAPSTTTTMEPAPSTTTTTTMEPAPSTTTTTTMEPAPSTTTTTTMEPAPSTTTTTTMEPAPSTTTTTTMEPAPSTTTTMEPAPSTTTTTTMEPASSSSSPATTARPTSPPSHCYVPNCVSCDPNNSIRCNTCCKGYTLTAIGVCIKRGCADAAALPVGTVGAALVSATVAMLSAMLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A550</accession>
    <name>A0AC62A550_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Heat-shock protein hsp70, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2820130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="XUY36929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="654" mass="71302" checksum="17158A359508D667" modified="2026-01-28" version="1">MTFEGAIGIDLGTTYSCVGVWQNERVEIIANDQGNRTTPSYVAFTDSERLIGDAAKNQVAMNPHNTVFDAKRLIGRKYGDPVVQADMKHWPFKVKTKGDDKPVISVQYCNEEKIFTPEEISSMVLLKMKETAEAYLGKQVKKAVVTVPAYFNDSQRQATKDAGTIAGLEVLRIINEPTAAAIAYGLDKGDDGKERNVLIFDLGGGTFDVTLLTIDGGIFEVKATNGDTHLGGEDFDNRLVTFFTEEFKRKNKGKDLSSSHRALRRLRTACERAKRTLSSATQATIEIDALFDNVDFQANITRARFEELCGDLFRSTMQPVERVLQDAKMDKRSVHDVVLVGGSTRIPKVQSLVSDFFGGKELNKSINPDEAVAYGAAVQAFILTGGKSKQTEGLLLLDVTPLTLGIETAGGVMTALIKRNTTIPTKKSQIFSTYADNQPGVHIQVFEGERAMTKDCHLLGTFDLSGIPPAPRGVPQIEVTFDLDANGILNVSAEEKGTGKRNHITITNDKGRLSKDEIERMVNDASKYEQADKMQRERVEAKNGLENYAYSMKNTIADTNVSGKLEESDRTALNSAIDAALEWLNSNQEASKEEYEHRQKELESTCNPIMTKMYQSMGGGAGGMPGGMPDMSGMGAGAGPAAGASSGPKVEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5M3</accession>
    <name>A0AC62A5M3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histone H3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1620310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="XUY37042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="66" mass="7238" checksum="D87F239EB5F19D1A" modified="2026-01-28" version="1">MPCARCRACRRRGGPALPEQRDPGDPGGVRCVADGCHEPGQHPREACVTVRPKDVQLAVRLRGERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5V2</accession>
    <name>A0AC62A5V2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tuzin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2020140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="596" mass="65648" checksum="F9C9C1B1D310707B" modified="2026-01-28" version="1">MLGPATRCCLLTAVRRSAFAQPGLEGLRIAAYAPAEPGVPPSPRRLPVAVGRVVAQLSPLVFAVDFRDSPPLPAVSLGSRVYVAYEREGAAPLPQQGGGVVDDAPGRGFLMGGFVVRVNPNGTLGVLLENNRVDLGVPPERIAVTEGVCKFVRHPGYLQVAEWVRSAGLSGADEVEGTACMLYHRGWRAERLHLLEASDTHCMTHLSQRSRMSLMEKAEWQRDHHRQMRSLSSERVKERDRRYTAAKYAGILSASVAFCGALSLFGWNYRNHLTHQRTSQMRFAVRTLCKAAPPGASTTADAAHQLSRQTRREALERWIRPVFQQLDTAHPRIAVITGSFGCGKSSLCRAAMREEGMVGVVVDVRVREDPLRSVIKALGVPHVEACGDALDFISEACCRAKSMMGGKTPVIVLRLREADSLARVYNEALALACERRMCHVVVEVPLEALTVTSTLLPRLDFYTVPNFSRSQAHEYIQHRLDALDTEAFLDTVGTSRADLDELLAAAHQRRVSPAEYTSERLLRAMRQLQAAWGDDAQLKTAVKRLAQRPYGEGRHVGLDGSSLSHPSLRDVVLYNPVQDAWHFRSRVLHTAAACLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A655</accession>
    <name>A0AC62A655_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amastin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2021190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="203" mass="21906" checksum="9648C3E3D02AD108" modified="2026-01-28" version="1">MCNIPCRAGIVMYCVLQLIAFLFLLVGTPTGQFRVPNKVAFSGGSCLTVWGLKNKCTSTKWDVRTSNLWAGCPERLKRFHAAEALSVASVVVSALAFLFGVVMLCCCRCLRGLCLVLNILATGCGCAVTALMVDAFYNNHENGPAQYNTSCYALRKNGSVTQPQAIADGDPVVTNYAYGAGFAVYIVGWSLCFINILFLMLPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6F8</accession>
    <name>A0AC62A6F8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SLACS-associated protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0220090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009371">
        <property type="protein sequence ID" value="XUY37394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="712" mass="77612" checksum="62560553E01BD8D8" modified="2026-01-28" version="1">MYPDTAEQEEEDTGSAPRSAEPRTETHTPPTQPPGTEGEGEENDTAESANTEPDQTVEDVSQTSDEARHRFHHGENTAAQQTGTIHCPVCPRTWTSRARRQQQTSHLNTTHAREVVRVDALKATGVDRCLSCGEFVIASGNARRAHGQKCGEFVTRAVRNQKRARTEQSTPRQDAVAEPTPETPPPPTRHRTRPTEADAEWVQEFPATIRTLRKQEWGHWAEAVGHTLLGYTAAAAAGRYQRQLALTELVRTRLAKPRAPAREEDESHQEEPSETPREGGRDEPYTGHAGATRRANTEEHLPTRDAHTAEERRARRILHQLSLGAVGKAARTLFQAQLPRARASEALDQLRTLHPQEDPAGYPCPPQTPFPHGLKPEKVRNVVLKRLGRAAAPGLDGWTRELLVPVVENAALLAETTALMQDILAGNVSASFAFRLRACVVHPFLKEPGSPKVRPITPESVWLKIASHLALDAVEKPFRDIFQGWQFGVWGDAAEAVTQIRETYASESADTLVALDATNAYNRVSRAWVLRAAYRHHALHHTVGVVDLSLGEPGALGVYEGGRRVEQLWSTRGVRQGMVLSPLLFATAVAETLRPIMAAHPLAKVTAYLDDLTVVGPRAAVQAFLDEAGPALAATGFDINPAKSHHLSKSAAPEPVSVAGVVVPLARGVVRILGAGFRGSGAPVDEWVGRKPARTRRTSPPLAGTSSHDTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6H9</accession>
    <name>A0AC62A6H9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SLACS-associated protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0220180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009371">
        <property type="protein sequence ID" value="XUY37403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="827" mass="90794" checksum="DC11A89E8539BC2C" modified="2026-01-28" version="1">MYPDTAEQEEEDTGSAPRSAEPRTETHTPPTQPPGTEGEGEENDTAESANTEPDQTVEDVSQTSDEARHRFHHGENTAAQQTGTIHRPVCPRTWTSRARRQQQTSHLNTTHAREVVRVDALKATGVDRCLSCGEFVIASGNARRAHGQKCGEFVTRAVRNQKRARTEQSTPRQDAVAEPTPETPPPPTRHRTRPTEADAEWVQEFPATIRTLRKQEWGHWAEAVGHTLLGYTAAAAAGRYQRQLALTELVRTRLAKPRAPAREEDESHQEEPSETPREGGRDEPYTGHAGATRRANTEEHLPTRDAHTAEERRARRILHQLSLGAVGKAARTLFQAQLPRARASEALDQLRTLHPQEDPAGYPCPPQTPFPHGLKPEKVRNVVLKRLGRAAAPGLDGWTRELLVPVVENAALLAETTALMQDILAGNVSASFAFRLRACVVHPFLKEPGSPKVRPITPESVWLKTASHLALDAVEKPFRDIFQGWQFGVWGDAAEAVTQTRETYASESADTLVALDATNAYNRVSRAWVLRAAYRHHALHHTVGVVDLSLGEPGALGVYEGGRRVEQLWSTRGVRQGMVLSPLLFATAVAETLAADHGGTPARQSDGVSRRPDRRRSTGGGPGVPGRGGASARGHRLRHQSGRKATTCRRARRRNRCRSPGWWRRWRAAWCASSAPVSAAAAHRWTSGCGRKPARTRRTSPPLAGDELPRHARMNLLRASALPRLTFLLRTHSTDELRDSAAWFDDRVLHTLSVLAGGAPIEDAAALLARLPLAMGGCGLRSQLAISRFAAQSVGRKGAQKAHTHQPDQHNLEALKTLPSRSLPSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6M1</accession>
    <name>A0AC62A6M1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SLACS-associated protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0220170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009371">
        <property type="protein sequence ID" value="XUY37402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="603" mass="65918" checksum="D0B4A664F718E8C8" modified="2026-01-28" version="1">MYPDTAEQEEEDTGSAPRSAEPRTETHTPPTQPPGTEGEGEENDTAESANTEPDQTVEDVSQTSDEARHRFHHGENTAAQQTGTIHCPVCPRTWTSRARRQQQTSHLNTTHARGGEGGRAEGHRGRPLPLVRRVRHRVRKRATSTRPEMRRVRHQGGPQPEARPDRAEHTPAGRSGGAHPGDTATTDTPPHQTHGGRRRVGTGVSRHDPDPPETGMGTLGRGGRPHPPRLHRGGRRGTLPAPARAYRAGAHSSRQTARTSAGGGREPPEEPSETPREGGRDEPYTGHAGATRRANTEEHLPTRDAHTAEERRARRILHQLSLGAVGKAARTLFQAQLPRARASEALDQLRTLHPQEDPAGYPCPPQTPFPHGLKPEKVRNVVLKRLGRAAAPGLDGWTRELLVPVVENAALLAETTALMQDILAGNVSASFAFRLRACVVHPFLKEPGSPKVRPITPESVWLKIASHLALDAVEKPFRDIFQGWQFGVWGDAAEAVTQIRETYASESADTLVALDATNAYNRVSRAWVLRAAYRHHALHHTVGVVDLSLGEPGALGVYEGGRRVEQLWSTRGVRQGMVLSPLLFATAVAEHCGRSWRHTRSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RGZ7</accession>
    <name>A0A088RGZ7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">D-3-phosphoglycerate dehydrogenase-like protein</fullName>
            <ecNumber evidence="8">1.1.1.95</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_030030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.95" evidence="8"/>
    <dbReference type="EMBL" id="CP009372">
        <property type="protein sequence ID" value="AIN95237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700945.1">
        <property type="nucleotide sequence ID" value="XM_010702643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RGZ7"/>
    <dbReference type="GeneID" id="22571869"/>
    <dbReference type="KEGG" id="lpan:LPMP_030030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_030005200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_030030"/>
    <dbReference type="eggNOG" id="KOG0068">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="418179at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047545">
        <property type="term" value="F:(S)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04901">
        <property type="entry name" value="ACT_3PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12176">
        <property type="entry name" value="PGDH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000041">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008759">
        <property type="entry name" value="PRK11790.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF282">
        <property type="entry name" value="D-3-PHOSPHOGLYCERATE DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="6">
        <location>
            <begin position="13"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="7">
        <location>
            <begin position="116"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN95237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="408" mass="43824" checksum="2E36D7E34ACB2B8C" modified="2014-11-26" version="1">MSSALIDSPYRALLLEGVDPAAKELLESKGCTVEAISSALPHDALLEKIKDVHFLGIRSKTRVTRELLDAAPQLLAIGCFCIGTNQVDLDYANKRGVVVFNSPFANTRSVAELVIGEVIALSRKITQRSEEVHQGVWRKTHLGCYEVRGKTIGIIGYGHIGSQVGVLAEALGMNVVFYDVVPTLVIGNATKVVHINDLLTFSDFVTIHVPETDITKGMIGEEQIQLMKKGSYLINASRGTVVDLEALAKALREGHLAGAAIDVYPEEPRANNELHVTPLQGIPNVILTPHVGGSTCEAQKAIGVEVGSALALFVTSGSTAGAVNFPQLVPPPVAKQNFRLTNVHVNVPGALKDINKIALDLDCNIGMQFLATSKAIGYLIMDVDKDVAAELRKRIAELKCSICTLIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RH60</accession>
    <name>A0A088RH60_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thymidylate kinase, putative</fullName>
            <ecNumber evidence="5">2.7.4.14</ecNumber>
            <ecNumber evidence="5">2.7.4.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_010090</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thymidylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.14" evidence="5"/>
    <dbReference type="EC" id="2.7.4.6" evidence="5"/>
    <dbReference type="EMBL" id="CP009370">
        <property type="protein sequence ID" value="AIN95110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696652.1">
        <property type="nucleotide sequence ID" value="XM_010698350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RH60"/>
    <dbReference type="GeneID" id="22571738"/>
    <dbReference type="KEGG" id="lpan:LPMP_010090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000031600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_010090"/>
    <dbReference type="eggNOG" id="KOG3327">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="425602at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:dTMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050145">
        <property type="term" value="F:nucleoside monophosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006227">
        <property type="term" value="P:dUDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014505">
        <property type="entry name" value="UMP-CMP_kinase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344:SF4">
        <property type="entry name" value="UMP-CMP KINASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019736">
        <property type="entry name" value="dTMP_TKRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate kinase-like" evidence="4">
        <location>
            <begin position="70"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN95110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="272" mass="29654" checksum="EE85EFFE2AE87947" modified="2014-11-26" version="1">MPSIAALSRTLHGGTSVYRSRLDSLKVLHAVAQSSPPWWTPSCSSFLRQAESLSTSTSAASARRHPVIVVEGLDGTGKTLITRTLAEKLSGMAVSTPPPQFAEVRETFRSQEEVVARAFYSAANYIAAEGILAASQSAVVVVDRWWCSTCAMALANAHNYDSLPPSGDAVYRWPEDLPAPDAGFLLCVDEAVRVARIRKRAPEDFEEQRLSSQSEMRRVAMEAYRRTNMLTEVAAPTYHVAVNSILRLLPESGVVHCAAAFTQAELDSIEPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHF2</accession>
    <name>A0A088RHF2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Probable eukaryotic initiation factor 4A</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP-dependent RNA helicase eIF4A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">LPMP_010760</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. eIF4A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="CP009370">
        <property type="protein sequence ID" value="AIN95175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696717.1">
        <property type="nucleotide sequence ID" value="XM_010698415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHF2"/>
    <dbReference type="SMR" id="A0A088RHF2"/>
    <dbReference type="GeneID" id="22571805"/>
    <dbReference type="KEGG" id="lpan:LPMP_010760"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_010011900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_010760"/>
    <dbReference type="eggNOG" id="KOG0327">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17939">
        <property type="entry name" value="DEADc_EIF4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000849">
        <property type="entry name" value="ATP-dependent RNA helicase DBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 21" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="20">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="57"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="241"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="15">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="AIN95175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="403" mass="45327" checksum="7AC069DCC7227164" modified="2014-11-26" version="1">MSQQDRVAPQDQDSFLDDQPGVRPIPSFDDMPLHQNLLRGIYSYGFEKPSSIQQRAIAPFTRGGDIIAQAQSGTGKTGAFSIGLLQRLDFRHNLIQGLVLSPTRELALQTAEVISRIGEFLSNSAKFCETFVGGTRVQDDLRKLQAGVVVAVGTPGRVSDVIKRGALRTESLRVLVLDEADEMLSQGFADQIYEIFRFLPKDIQVALFSATMPEEVLELTKKFMRDPVRILVKRESLTLEGIKQFFIAVEEEHKLDTLMDLYETVSIAQSVIFANTRRKVDWIAEKLNQSNHTVSSMHAEMPKSDRERVMNTFRSGSSRVLVTTDLVARGIDVHHVNIVINFDLPTNKENYLHRIGRGGRYGRKGVAINFVTEKDVELLHEIEGHYHTQIDELPVDFAAYLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIB3</accession>
    <name>A0A088RIB3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavoprotein monooxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_061230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704004.1">
        <property type="nucleotide sequence ID" value="XM_010705702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIB3"/>
    <dbReference type="GeneID" id="22572329"/>
    <dbReference type="KEGG" id="lpan:LPMP_061230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060018700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_061230"/>
    <dbReference type="eggNOG" id="KOG3855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="683240at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000402">
        <property type="entry name" value="Flavoprotein monooxygenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051205">
        <property type="entry name" value="UbiH/COQ6_monooxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="1">
        <location>
            <begin position="231"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="503" mass="53292" checksum="B05B7DA193F00131" modified="2014-11-26" version="1">MLCRSLSMHAPSPAAAHANEVIVSGGGVVGAAMMASLQQLRRHLHSSSAGQGGGGAASLLTSQLTHLMLVNSGKRPVYDAANMMDRLRTVSITPVSSKIIDNLGAWDRLTTKHPYYRIAVRHEQANSPYLGAGSRSSSFFMTSVLGNSTSSEPLLEFTDLRKPVGFICFNTELNSCMMDVVEAQQCALADTGADAAHDTVCFGARLEGVRIPSRGTLGGPWGSAKLAVGETTTDVTFGLLLGCEGRDSPLRDVLSTPALQHDYAQAAFVCTVRLEKSDDGNVCAFQNFFRDGKIVAMLPTSEDTANIVFSTTPQHAKELLASTQEDLVAELNRRLCAFASNDIPKILEVPQTSTSDGKVHRAQGSFPLKLNVATTPYAPRAILLGDAAHSIHPFAGQGLNLGIYDLCALTSVLEQAIRSGQDVGSSVAVGQVFAGHMLSHTAPVIAGMEVIKKLTYWTPGLASVGMKALNSIPVASTLAKDAILQVSSGALFAAQHRRSYLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJH9</accession>
    <name>A0A088RJH9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_090490</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN95965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704287.1">
        <property type="nucleotide sequence ID" value="XM_010705985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJH9"/>
    <dbReference type="GeneID" id="22572619"/>
    <dbReference type="KEGG" id="lpan:LPMP_090490"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090010100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_090490"/>
    <dbReference type="eggNOG" id="ENOG502RG3Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273257at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005242">
        <property type="term" value="F:inward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034765">
        <property type="term" value="P:regulation of monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1400">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016449">
        <property type="entry name" value="K_chnl_inward-rec_Kir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013518">
        <property type="entry name" value="K_chnl_inward-rec_Kir_cyto"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767">
        <property type="entry name" value="INWARD RECTIFIER POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767:SF102">
        <property type="entry name" value="INWARDLY RECTIFYING POTASSIUM CHANNEL 1, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0630">Potassium</keyword>
    <keyword evidence="2 7" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <keyword evidence="3 7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="328"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="351"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="374"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="442"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN95965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="672" mass="73239" checksum="4535506E73CED5A6" modified="2014-11-26" version="1">MLRGVSLTPQERAVKVPHDLPSELKSSILGVPLFDVPPDYGSTGVSRPGFSVRGASSPAWCGVSQTQGLSRRPALASLMSRMCCTKHRDPRSLTGQVPVFDDRGHLTAHQVGVNTFRFRSLSLFYFLRSQSWTILLTYSVALYLIIVLLITGAYYAWGMACGAQVNVVSAIYFTVVSLAANGGYMGEDEDVMSVATHRCYSGRTAIVMVCSYVNILFVGLVAALVVGKAAHTDKLGHRVVFSDFCTLTGLPGRANPWRLVFRMANVDNHIPLARGKLRLFCVTAEPLKEYHIQQQQPQALRDAHLVKELAGSTGECTHQHLLRVVLVGGDGEGKPQRTAVPATESDENRHAAKAQKRRKKERSRQCSPPAPHDSAGRSSREDKSRPAPAQRHHRRRKQRDQQLHTTGSGIRAGEAASQGGHRGQRSEGRGGVQCTEREAHQSASSSPSRSSSASSSRTTASSTLSTSASSSHSSGASSSCAASAVKRSVLPTGIPEPDVSLSMQSHGFVENNGHVMERVHLCVREMRWTCAGERYLDHGESGQLSLWYPTEIIHIIDERSPLHPFLELPHVAASLGSGGTSAEVPSTFASRADVVRAHFQIVAVFDATEMESGSTITAKRTYTSEEIITHYKFSDRLVHIHSQSNEVMLDFHYFNSLLPVDLVEPSTTESDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJM8</accession>
    <name>A0A088RJM8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Spermidine synthase, putative</fullName>
            <ecNumber evidence="6">2.5.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_040540</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.16" evidence="6"/>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="AIN95379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703701.1">
        <property type="nucleotide sequence ID" value="XM_010705399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJM8"/>
    <dbReference type="GeneID" id="22572013"/>
    <dbReference type="KEGG" id="lpan:LPMP_040540"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040011700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_040540"/>
    <dbReference type="eggNOG" id="KOG1562">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="38125at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004766">
        <property type="term" value="F:spermidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.140.10:FF:000015">
        <property type="entry name" value="Putative spermidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.140.10">
        <property type="entry name" value="Spermidine synthase, tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030373">
        <property type="entry name" value="PABS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035246">
        <property type="entry name" value="Spermidine_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037163">
        <property type="entry name" value="Spermidine_synt_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002010">
        <property type="entry name" value="PRK00811.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00417">
        <property type="entry name" value="speE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558:SF11">
        <property type="entry name" value="SPERMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558">
        <property type="entry name" value="SPERMIDINE/SPERMINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17284">
        <property type="entry name" value="Spermine_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01330">
        <property type="entry name" value="PABS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PABS" evidence="5">
        <location>
            <begin position="9"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN95379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="300" mass="33146" checksum="699736EBC8B35155" modified="2014-11-26" version="1">MPGPGLLSDGWFREKSSMWPGQAQGLKVEKVLYDQPTEFQHLTVFESDPKGPWGTVMALDGAIQLTDYDEFVYHEMLANLSLTCHHKPERVLVIGGGDGGVVREVLRHKSEKEGIVQSVELVDIDGAVIEQSKRHFPQIACGLANPCVTAMVGDGVAFVGNAPDNVYDVVIIDTTDPEGPASELFGAEFYKNVRRILRPGGIVCNQGESIWLHRPLIEKMMSFLKKDIGFTTVKYAMIYTPTYPCGSIGTLVCAKSVDTDLTVPRRPVESLGFADELKYYSSDMHRAAFVLPRFAAYLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJN5</accession>
    <name>A0A088RJN5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_101030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696825.1">
        <property type="nucleotide sequence ID" value="XM_010698523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJN5"/>
    <dbReference type="GeneID" id="22572840"/>
    <dbReference type="KEGG" id="lpan:LPMP_101030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100017400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_101030"/>
    <dbReference type="eggNOG" id="ENOG502S0W7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="239418at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN96172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="139" mass="16275" checksum="CF623F880066F69C" modified="2014-11-26" version="1">MHDANRFGGRTAYLREIGPIDHKKKGRLFKRDLATLQFNVDVWCAQQSLRKQWKGRDWDVVEMPFELAPKELQRVVPEKYTDVPMMTDPVHHDYMNIRRKVFDREALQGALYPNGGADQSPYPAIQRVNRAAMTLDKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RK42</accession>
    <name>A0A088RK42_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_110940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696941.1">
        <property type="nucleotide sequence ID" value="XM_010698639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RK42"/>
    <dbReference type="GeneID" id="22572959"/>
    <dbReference type="KEGG" id="lpan:LPMP_110940"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_110013200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_110940"/>
    <dbReference type="eggNOG" id="ENOG502S4DX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272691at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="101"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="320"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="377" mass="42567" checksum="D2A33849EE3965F8" modified="2014-11-26" version="1">MVFDVNGDFVENEQQFNEAARKSINLTIKLQNTSGMSELIARVLEDDDRRASGAISASGLDFDELLRTTPRFNFLSSDHPLFRRYNKRLFQQRQAAALIAQRTAEAELQRQIEIKERLRKALEEETALQAKKEQEKAERQRMISAQEPARFVPEEPFLKIIKDESAFGQVERELKKPELAAEPKVDIKAEVGLSEAITNSATCTSATPSNDAAATLSAEELLVLVGVPTEKIETETPALEDLAEAIALPPSENTATYITLPAEEYTLCSGERVVSIIKKRTGPIPAPPPGKPPVINKAAASRLNESVKRAKPAKKIARNYTPSDEQQYKRQQCSRSPRSRRRSERDHSSKEHSRRHRRDEAPSYRHHKTSRDSKYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKD7</accession>
    <name>A0A088RKD7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_060650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703946.1">
        <property type="nucleotide sequence ID" value="XM_010705644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKD7"/>
    <dbReference type="GeneID" id="22572271"/>
    <dbReference type="KEGG" id="lpan:LPMP_060650"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060012200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_060650"/>
    <dbReference type="eggNOG" id="ENOG502RZCK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271070at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="244" mass="27721" checksum="DD815C6A9945472E" modified="2014-11-26" version="1">MGAKGSKTSSSSSAVLAATTTAGEKQDMAKRWDGSVGNVSDADLGVTPDVSLYSSISTPEENAAKRKAYAHLKSPYAKRRPGASAKVERGGVGDSSAATSFTPHMNLIEQIYNEDFDTIDHIQALRLPPVVARQLKSTVRDEAERRCAEVEKRMARCLQDKMWTSWKCQKERDTYYRCVEDTEQRNLRPDPVNPDWVDMLTSFRWKYNLGVFHGEIIGRNNIMREIWREHYPDRELPHPWVKDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RL05</accession>
    <name>A0A088RL05_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Calpain-like cysteine peptidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_140830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697315.1">
        <property type="nucleotide sequence ID" value="XM_010699013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RL05"/>
    <dbReference type="GeneID" id="22573350"/>
    <dbReference type="KEGG" id="lpan:LPMP_140830"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140013400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_140830"/>
    <dbReference type="eggNOG" id="ENOG502S2FD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="274748at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000033">
        <property type="entry name" value="Calpain-like cysteine peptidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015232">
        <property type="entry name" value="DUF1935"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036310">
        <property type="entry name" value="Smp-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47047:SF8">
        <property type="entry name" value="CYSTEINE PEPTIDASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47047">
        <property type="entry name" value="PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09149">
        <property type="entry name" value="DUF1935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101601">
        <property type="entry name" value="Smp-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1935" evidence="1">
        <location>
            <begin position="6"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="115" mass="13084" checksum="8407310BDACF5099" modified="2014-11-26" version="1">MSEIKYENAQPTYSGNTVVKCFKDNGNGLLFRIVNDEEHKWAFYNDTTNYNMVVKVAFGKDSRVEPIGNTTMQRDEESGEFKCELEIAPMVTEMFIEGEPNGFKISFEANPIPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RL87</accession>
    <name>A0A088RL87_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="12">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_140730</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="12"/>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697306.1">
        <property type="nucleotide sequence ID" value="XM_010699004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RL87"/>
    <dbReference type="GeneID" id="22573340"/>
    <dbReference type="KEGG" id="lpan:LPMP_140730"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140012500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_140730"/>
    <dbReference type="eggNOG" id="KOG3072">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF17">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIN96653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="297" mass="34034" checksum="747EAA170085B606" modified="2014-11-26" version="1">MAPAVLQAMLNIGGLPSQFDGNVAENFFDDYFDVLFYSGVLYILIVFLGPKAMENREPFKLKYFIAMWNLTLSLFSFCGTIAVGTLLMYMLEDRGMYETTCQLDRSLYEGELAFWIFAFMLSKIPEMIDTVFLVLTKKPIIFLHWYHHLTVMIFCWYAGYLIIPSGIWFAAMNYFVHSIMYFYYFLCSLGLRKVIRPFAPFITAAQLLQMVAGTAIVLYTFYYSYISERGCNADRRTIRMGVGMYGSYFVLFATLFARLYIKKSGTAKRKTAAAAFNQADKSVEAVMNGCNGTKKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLZ9</accession>
    <name>A0A088RLZ9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_170390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697730.1">
        <property type="nucleotide sequence ID" value="XM_010699428.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22573782"/>
    <dbReference type="KEGG" id="lpan:LPMP_170390"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170009300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_170390"/>
    <dbReference type="eggNOG" id="ENOG502SH9Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267461at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="621"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="670"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1012"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1089"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1198"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="709"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="752"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1022"/>
            <end position="1031"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1324" mass="141185" checksum="8D091700AC870D61" modified="2014-11-26" version="1">MSRFPNFRRDSDFRHDEESSKSMSQVQTRPAICLDTSLSFISTASVLAGTTSGPASPLLGPLSCDSVNDVCNSGAAISSPALFHTRDPNVEASGQHRLQSLKATRSRTISGSRSVHSSSRPYSKQQQSQHQHHHHPLSLSSCSPSVNRDYHAHSRLQRAEQAHCLASEADCSKLEVLESEATVLTRPSDPRPYGTGADGEPGVHSQRVMSATVSPVPRHAVTLSNDFEGVVSIPVSEGAEKYDEEASRGGSSTYAAPTNGSEKSIVDHDARAEDHEDDATSPPRTTPPPRRAFVLSRRCSGTDVEGDALIDNAHPPRPAAEGVERRGSTRMLPVDFAADAPRGSTVLVMDNGDEDEECACRNDKSAATIIAHPFAAADAPLAEDPAVLPLTLPVSRLAHGVVMEGTEKDMHRSAAFTARRASAAERNSVSSHRGRLSSAGSSMMSPMPRPVPHSTQTTAASPRLSPARAREGLDEKVVMAVRAVRDDAGDTTEQQQHWAGTKVTLANDAANASAHATTTTAATAASTTQDLLSFRMHSCILPGSSMLESELQAVPTIPAQLDATTALTTTADDEPASVTPLSSLTMLNSVAGPSLSVTTAAMSSLWLVSGSTPTPLRRLRDRDREVSTTLDVQEGERKEVSKGSDSAPDQTERVLKLVDDASTAAVTTPETRAELHGHVNSSSAPADNSVEAEQPLTSAVDAQRPRRSSAPQYTTARLATSPSIAAPSFSPEPARPQAEAHRPSSPCLTAGTDASISIQLNPLPSNNDAVAPADPRPLPSPEAATTQHRYCTATPPPFAIAGTHCRLADTASSMSSPSSTESARVSEEVKELVKRAQAEVCRTRESLLSTLRDHRASFHLSEPSPTPKNTTSATVLTVLAQSTAAASTTACVSPSVSPTPTRSLLLPTALVTAAESSTPPSTALTTVSVPTTRTSGDWRSAAVALRPQLRAAADAILRRLQGYDARDHGVLPMETVVRVTYFVITRRQMPPATWSLRTAEGTLAVTPMQASMAASGGGATPRSESAQLSSPNVESCRAALLSGVPLGRQLSSSEAGGPRRCVAAASHRVFETPCQQRFSLNAYDATTRAGVNGSPFSSSRPVGQTRPRDSSELGAAANDEDETARAECHGRPATCISPSRTLEHVMTLQQRRAEEGLYLKFYLTVLEAFKQVFGERYAWRHLGATNASRHDCTITVAQPAQKRRRTNNAPASERSDHRGQAYLTRVEVDAEEVQLEVTNEFNDVREPLETLFPRLRQQYALIQREKRDAAVTPTVSLTANTSDLLTAEPARTEATAAAMGLANRPPPLDVLVYYRTFIESLREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMR9</accession>
    <name>A0A088RMR9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNaJ family chaperone, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_190050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698000.1">
        <property type="nucleotide sequence ID" value="XM_010699698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMR9"/>
    <dbReference type="GeneID" id="22574059"/>
    <dbReference type="KEGG" id="lpan:LPMP_190050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190008800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_190050"/>
    <dbReference type="eggNOG" id="KOG0714">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051964">
        <property type="entry name" value="Chaperone_stress_response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="5"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="432" mass="50600" checksum="B56E214F86F0DDA3" modified="2014-11-26" version="1">MDKQDYYTILGISRAANKDAIRQAYKLKALQLHPDKNPNGEAIFKLVVNAYHTLNDPTKRSAYDRELTRRERGFGAHPYRQAAPQPSSPAAYPSSSSGADAGTSRKPRFATDEQLFKDAYEQYKKTPFSGTPNGGFRGATSEGTFAEWFKKKQEELRRAEEVTKAKAEYAKNLEREEQRRAEEWRNMQRRREEEREEEIRQAKEQRERDRDMLRRKSEAEAKEQRAAEQKARMEAYAEVQREQQADVERHLRDVASQKRELAEERRRLAEERAEVTNLAAEHRFTRDMAQKQRGQELADAVRRADAKVREAQEQQAFREASERAKAEERVREEKRKHAEEERASETEKVRELQRQKEAEAAQQERTRTTAELGEQRKRVMAQMMSERRKHEEEVSAMRKETDRIEAEMKAKLEALRAAKSSGQTINLDDWKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RN07</accession>
    <name>A0A088RN07_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucosidase II subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LPMP_180090</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; N-glycan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697843.1">
        <property type="nucleotide sequence ID" value="XM_010699541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RN07"/>
    <dbReference type="GeneID" id="22573899"/>
    <dbReference type="KEGG" id="lpan:LPMP_180090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180006000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_180090"/>
    <dbReference type="eggNOG" id="KOG1066">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3237269at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090599">
        <property type="term" value="F:alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06603">
        <property type="entry name" value="GH31_GANC_GANAB_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033403">
        <property type="entry name" value="DUF5110"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF54">
        <property type="entry name" value="BCDNA.GH04962"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17137">
        <property type="entry name" value="DUF5110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10 16" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839014" description="Glucosidase II subunit alpha" evidence="11">
        <location>
            <begin position="22"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="13">
        <location>
            <begin position="123"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="12">
        <location>
            <begin position="244"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="15">
        <location>
            <begin position="586"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5110" evidence="14">
        <location>
            <begin position="690"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AIN97190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="812" mass="91045" checksum="E678953F43D15576" modified="2014-11-26" version="1">MLRSALSVILFSVLLLGSNVALSVPVVTTEGGLALEAFGYTNGVVRLTAKPEKSWTYQPDGIILPAAAPLLAIKGVNGAQWSIPHGDCMLTVSIVTPHVRFEFSCHGNSLIEATAFSNATAAPEVNFTFPVAQTMYGLAEHAADLPLQGGQVYEMYNTDSFHYPVNSTVALYGAIPFIMAYGPQSTCGVLFLNPSETNVEVSADSAAPSCRWQPEVGAIDIFFMPGPTPANVQQQHATLTGPTVMPPYFSLGLHQSRWNYMSTKDCLSVDEGYDAHNMPYDTLWLDIEHTDKKKYFTWNPYTFPDPKVLTDALASKGRKLVTVRDPHVKRDSGYNIHQEAKEGQYYVKDASGMDYEGDCWPGRSSWPDFLNTRTRDWYSQLFHDDHYPGGSHDIHTWVDMNEPSVFHGEKATMAKTAVHTLDNGQTVEHRFVHNAYSFYSVLAVHKGMMEARGSNEAPERPFILTRSFFPGSQRYAAMWTGDNMARWDHLENSIPELLSLSISNYPFCGSDVGGFFFDTEEELFVRWMQAGVFVPFYRTHSHCETQRREPWTFSVEAQSLVRNALALRYALVPYLYTSFYHAHTEGNTIMRPLFYEFPGQPELREVQSAYLFGPSILVQPVVKPNVTEVTVPLPKETLWYNYFSGELAVGQHTMSVDKGTMPMFLRGGHIVPLKLRLRRSTFAARLDPFTIFVALNAQGNSYGDLYIDDGVTYDYENGAFVHRAFSYSNQVLQSSAYHDSPGDTVLFHATNVVERIVIYGYVGRASKVVLSTRVDQTEVATPLEFEQVGQTVVLRKPNVLVVADWFISFENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RN25</accession>
    <name>A0A088RN25_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amastin-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_140480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697282.1">
        <property type="nucleotide sequence ID" value="XM_010698980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RN25"/>
    <dbReference type="GeneID" id="22573315"/>
    <dbReference type="KEGG" id="lpan:LPMP_140480"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140010000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_140480"/>
    <dbReference type="eggNOG" id="ENOG502SIPV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272145at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009944">
        <property type="entry name" value="Amastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297:SF4">
        <property type="entry name" value="AMASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297">
        <property type="entry name" value="AMASTIN-LIKE SURFACE PROTEIN-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07344">
        <property type="entry name" value="Amastin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="276" mass="30562" checksum="4BCB287D74D3B2D6" modified="2014-11-26" version="1">MPSDFNMNHEPLTEISSLRTSRRPSSLHRRKSKIGGRTVLYIPYRERVFIALAAVMQVAILALLIAAVVTDIFKVDGTRAIRIGADLRAVSAGLNVSVTEGSRPFCYSLWGARKCGSTSFYTQEWYTARGIADKGFPSPVTLTMMLGAAAFAVLAVCYSLVNIIGIALVVCLQNYTAVLCAWSFSVWITILISWALSVGVYARSILTMNSTTIVGRKVRVRDYCDFSSSFALSMAAFVLHALQFTFTVLYVHMFESRMKSLVTEQKQLNEAPHDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RN67</accession>
    <name>A0A088RN67_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_140580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697292.1">
        <property type="nucleotide sequence ID" value="XM_010698990.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22573325"/>
    <dbReference type="KEGG" id="lpan:LPMP_140580"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140011000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_140580"/>
    <dbReference type="eggNOG" id="ENOG502SHJM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265224at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839009" evidence="2">
        <location>
            <begin position="20"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="633"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="690"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="744"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="857"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1048"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1187"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="642"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="750"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1059"/>
            <end position="1081"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1309" mass="141817" checksum="64387FBE75FB0EA2" modified="2014-11-26" version="1">MVFLRLSRVPALAIGLTLASPTFSDSGSEAETGTAMQWCYVERSSSYSVSYDVLWSHWATIVTPPPGRLTGSKLALVPYFAEAHHDEDLITWRRLQHYAERATAVLFGEQPANSTTPESRRLCALLAVLNDARAWATRQPTTNPLPVLLSDETSVPQRLLFQWFMFLGIQNASSSQCRPSIELSTEIHAIAFAPGWWAELRTCNSLCSLGQWLDLVSQWLTVRALEAALGLLPSTLQWRTGSASAVETHLLFRADADSSWCCSADLCSRAEGIACPTGKEGGFAHLRLSRWMRYRATASRAAAAPLSLPFIEAALPEISKAEAVLVWVLERLMCAVIGSADGSRKLPCGSATAHALLLEPEAHGVVTCRLHLSSPPHKWQCNGSLAPRVGAPSHSLFPWSSSAPPLGRAAQAPVVAALLSWYAVDFEVVFGRLYRVWRLAQRHHFRCLTGSRNDIGAADAAAPHHNDPWRGVVETAMRCCSGDAGGSAQAHEGPALGLLGHCLLLAMWMSLSVVDVDEGVGVASLSPPLARKGTLYYSSRRNVLHVRDWGTALHLRYVASCLSIDEGQVIYDDTEHAGALQNGAQRRREYCGTVVKQTVSIVVSAFARARTAAVATQARARLQAQSNTRLSCCETHDSPGHTTTASRGAGDSAGSGTCRILDIWDDDGAAAEEGAECVLLSWSCAAAEEASESHEGSPGVTLVQHQQSKQRTGDDAPLASNDLLCSSSLQSSWMDYSIEEFADENESTISQSPASHASAPQAKEDQEQSALDPAVVAPLLDLESHLRELLTRSAVSELLRLVGLAERLARHSCEDVEAAAQPRLVSHARSHSVRMEAQQRSWSSSALHVETVQLHEDEQPPQHAAPAYVDVPLPTPPALASTASSRAAHLREDEASVRRTLCGAEHRLRQWLHVRCTHTGALLLLQSQETHRRLHLSQLWALEQEEWQMRWRTVLVPECVLRSLLSEKAAAGVWKTLPQQEEPQQWQQCGCQPQNGRLSYSSQRHQRDQRCSVAAPKIGTPPAAPTAEEARAHQVFLLYGDVEAIDREAPDRSLKRSPPTRTEASHGSPSCQRNQQESQFRLSAPLRSPSLAMWPRHVPRQRHSIKSGASRPASSCATAGAAHSAVPVLSVSLCEAPSSTPARGSTGRCLNELPLNHRRTDARLACITPPSTAMGWGLLTGNGDALVNREPSSGKSGPQRHGGAHCDDAARRRLSAGGSASVAFAETICTAAALECKRADRGSRSTPLGAVPPAFHTAKEKVAPDADHRISAAPPVPRHTTIHSLSAASVPPRRLRKPVVTWLEDVQQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNJ4</accession>
    <name>A0A088RNJ4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_190720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698068.1">
        <property type="nucleotide sequence ID" value="XM_010699766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNJ4"/>
    <dbReference type="GeneID" id="22574126"/>
    <dbReference type="KEGG" id="lpan:LPMP_190720"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000052100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_190720"/>
    <dbReference type="eggNOG" id="ENOG502QTI1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="15794at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026669">
        <property type="entry name" value="Arsenite_MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43675">
        <property type="entry name" value="ARSENITE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43675:SF1">
        <property type="entry name" value="RIKEN CDNA 2700097O09 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="520" mass="56690" checksum="A91A9834C478B42F" modified="2014-11-26" version="1">MGRVESMLSALTPILKRHQLGSWKPAEVERLCTMLRKYGKHEPQEKCGTYCNSGITTTAASLPSPSSAPSPPSSRDDNVQGESDTDEEAFVGAISEVDRCLNLVRNFLKRRMPFGVVVEPTVPAGIAEPQAPQSSITGTSSKKRARSPSGEARVSAPASNGVHSGAAVVAAPVYAVDAFLYSEADIEKLVEAKKVAREYCCRCGSTDIRLSEFITHSFSQDQLLYLSCFLLPHLLEVVVASDEASRPLSIVDVGSRLGIVLWACAFALQWGILAPQRSVAAAPEVQLVGIELDATFVKISQDTVRRFFAPRRRHAPKLSLPLQTAGAGDVSRELADVSSSIQLLQSDCFEGDAAAALCSSALVVMHNVFEYFCASAVEHARCWLKLHRLVHRSGQLLVCSPALEVTFGTFTDEVWLQACQLENEKDAGATSTPLAWLESYVEPFDTNDVTSDFLTLRALSREGCNSDGDGAVHDENQHDRHHGHRCGHLHHSRSEADEGDEEAVSEAVEQIQRIYVYRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNN4</accession>
    <name>A0A088RNN4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycerol uptake protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_191180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97460.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698113.1">
        <property type="nucleotide sequence ID" value="XM_010699811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNN4"/>
    <dbReference type="GeneID" id="22574172"/>
    <dbReference type="KEGG" id="lpan:LPMP_191180"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190019000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_191180"/>
    <dbReference type="eggNOG" id="KOG3860">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="420606at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97460.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="749" mass="84034" checksum="7D1AA7E3896BCA54" modified="2026-01-28" version="2">MRLPQPRDAAALLPPPPSSTLTTSRGCRLHLLSPTTELDIGAAEYSTIYSRLCSIEYLLPAATCLLLILYGFAILASFCNKNFSSYKLNVTEAMPLLGRMGSKGYDNTMDDQWTGFSTNYNTLVCVALILGGFSAFYRKLLFRQTASSSYPSSGAAVSPLLLVNDELSAALGSRVRAQTSPVVCGKPHPRCRALRPLSVAPRGCTAFLQGAWILPAFYTITGFIFVAAVHGPHFFLPLLLIIANYVIFSRLQRLCPYWLFMATMWATHVAGLYIIEIANGFEGTYWLQYFFTTSADEALNLLGYEQKPLWDTNMRWAISFRMSTLRLISFNYDLWEATHAAARARERATAKHDATCIECAQLREQNAALAAALPAEASRCYKYRTEYPRDPADYNFVNYAAYTLFPPLYLGGPMSSFNAFVSYMRVPSTSMPLRKMVTYAFAIFRIYATTVLLLHFVHVPALARHSYLITEMSLPEQAHFVFLTLAYLWLKFNFIWKSSRLFAMLSGIEVPEDMRRCFANTLTVRDFWRDWHASFNLWVVRYMYIPMGGSSRVALSVLPIFLFIALWHDPVLHLVKWALCIAVMFMAEVAVSGCFGWTVAAFRREMAAVALTGAVNDATLERESPITDPVRRRLLARLARLCARRLSPRVQSFLYRQLRVAAGMSSVFGLIVANSVGFSMQNGLTDSNGGAKPAHADADFLIAKALMRVTPTFTLGVVAFMYSVSSLAVIDREMTRQQTLSLKRLYCLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNP3</accession>
    <name>A0A088RNP3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cardiolipin synthetase, putative</fullName>
            <ecNumber evidence="3">2.7.8.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_201780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.8.-" evidence="3"/>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698379.1">
        <property type="nucleotide sequence ID" value="XM_010700077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNP3"/>
    <dbReference type="GeneID" id="22574387"/>
    <dbReference type="KEGG" id="lpan:LPMP_201780"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200023200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201780"/>
    <dbReference type="eggNOG" id="ENOG502RKKV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="14911at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030572">
        <property type="term" value="F:phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09110">
        <property type="entry name" value="PLDc_CLS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09159">
        <property type="entry name" value="PLDc_ybhO_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000059">
        <property type="entry name" value="Cardiolipin synthetase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000058">
        <property type="entry name" value="Putative cardiolipin synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21248">
        <property type="entry name" value="CARDIOLIPIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21248:SF22">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="620"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="726" mass="82556" checksum="772A5C5DB3AAE60E" modified="2014-11-26" version="1">MQLLTSANMKPKLRQVFLSAATTYGQFLEVAKALEPSPSVLAFSASTPSPSPQPLPESSDSSEAGGTAAFYLDKMQHTFKEAKRYYNSTPFDQRWDDILSSLAVLGRMSRGNRVVPFHDSAMAFESMWAAVKEAKERVHWQTYICKDDFIGQGTVRRLVQAHQRGCDTELLYDCGGNISGRARLTGELKLCGAKVIPYRPFFRSVATYFIKGLDWRRSPGLRNHRKILLVDTCQGFCGGLNVGNEYCGKAAGGTGKFRDTHCGVVGPAAAHLAEVYRDTKQPHPWKYGWRRWRQIASQQITRRVKQGRMRMERNGLYRAFQEERGRSGRRLQNVSSASMKVMRRRWHNQKNQLLTLMQWSRARLSSNVLLGHEALRHTQEQSDVRLDGKEANVKVGTVVNGADSPKSNVKAACQAPGLFAVKDANDGGTASASLSSYELSTSSAGPREGARAWPSSPLQSSDGKLNAPRSSAMRRKLLAARREALYRATDLPHKRTYTDMLRQVPILDTEPVPEAEMYLQHREPITQVLSCNPRYRDYSIQYAFWQVTRKCHRRIWITTPYYLPTRKLFSALIQAARRGVDVRLLAGSNQTTDPWFMWHASNYITEKLLRAGVKIYEFKGQQIMHAKTVVVDSVWSSIGSYNWDLMSNRNLEVCLCHLDLEVAHSMETQFLRDLTQSVEVRLEDHKQRSRWLRFTSWLFYNFVFLLDRITFRSFANEDVVDVPGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNP6</accession>
    <name>A0A088RNP6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA uridylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_191290</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>RNA(n) + UTP = RNA(n)-3'-uridine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14785"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17348"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173116"/>
            <dbReference type="EC" id="2.7.7.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="2.7.7.52" evidence="3"/>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698123.1">
        <property type="nucleotide sequence ID" value="XM_010699821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNP6"/>
    <dbReference type="GeneID" id="22574183"/>
    <dbReference type="KEGG" id="lpan:LPMP_191290"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190020000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_191290"/>
    <dbReference type="eggNOG" id="KOG2277">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2274644at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050265">
        <property type="term" value="F:RNA uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF98">
        <property type="entry name" value="RNA EDITING 3' TERMINAL URIDYLYL TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAP-associated" evidence="9">
        <location>
            <begin position="478"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN97470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="934" mass="104932" checksum="A86660F234F3035C" modified="2014-11-26" version="1">MGEEEENDVIASAFSTEAILEAVSRAVALTYEKCSLCGNIIEGEIEHVLREHPHLKHIHAMVAKPIPPLSACRSHGAAAMDLGSFAVATSSKADRGEVAFRVVHRAQAQLHRLLSGMHGCEGHVYPFGSIVSMGSWDGIGDGDFSFVCPELCYAPPQDEQAVVPVEAVEQDSDDETMTEGKKGYEVQESSASGEADTTGAVAATALRYMDLAESVENAAMEKVQSSMQPLCDEKRIIHKIAARLRGAGFRFEELDLVLRTRIPVVRRKRAEQEPPPLNPVPQASFICIRFDTASAENEFRKERLKRLIYIYKATEILSRGRQRGRSLVLSVPDSTDAIHLMAQRERIRGVRKEWLDNHRSPEIFSIDFDISCRHHGIRNSWLLRRYFAQNEVFRVGNVFLKMWSKACGVNNSRVGFLTSYSISLLWIYFLLRRGEAAFVNPADIPELPNREEQMEVSYIPLWPAVANAKANADRTSRLGGLLQGFFFFYGEEFCWDTHVVTIRKPYDTATAIPTKEDLGWDKSDTLSLVLRDRCYHIFSIEDVYEEDLDLGRHLTPNKAAWARLQFRLAYRQCCTAWRAGPGAGASPLWQLFDTPRKRAEDVLRARLYAYLLRNTKDAAAPIANILEQLCVSNESNPGNVSAEEDPMYLPCAYELGNRLCDLWFDNAQVAQDIAFHKMYIRRNTDYTPPANPMMHGEWAAVCTDDLQEHHDPKTAHQQRSVRLAPPVRKGSDTTASNLQAMCASSHERTMQLVTSRRQYEECVLMLRKHPPIPKQLPAAVVGVSLKDHAGTLYPHCFYPLQGHRLFGTYEARATFIRCVGDVVEELARLRGNNTPRELEQGGNVLHNRENLLLHLKKQLCPSTVATDPTYKAVLKFICLPTEPYIQATQLQPQGKEPPTLHPTPLLLSLANRNSSGFSVAAKPKDSRAPPPLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNQ1</accession>
    <name>A0A088RNQ1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oxidoreductase-like protein</fullName>
            <ecNumber evidence="6">1.14.13.39</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_191340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.14.13.39" evidence="6"/>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698128.1">
        <property type="nucleotide sequence ID" value="XM_010699826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNQ1"/>
    <dbReference type="GeneID" id="22574188"/>
    <dbReference type="KEGG" id="lpan:LPMP_191340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190020400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_191340"/>
    <dbReference type="eggNOG" id="KOG1158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004517">
        <property type="term" value="F:nitric-oxide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000084">
        <property type="entry name" value="Oxidoreductase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019180">
        <property type="entry name" value="Oxidoreductase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF128">
        <property type="entry name" value="NADPH OXIDOREDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09791">
        <property type="entry name" value="Oxidored-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase-like" evidence="5">
        <location>
            <begin position="3"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidoreductase FAD/NAD(P)-binding" evidence="4">
        <location>
            <begin position="429"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN97475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="586" mass="64176" checksum="65ACACE568F82621" modified="2014-11-26" version="1">MKRPRKPAPGECCGSGCTRCVWDTYYDELARFEEFIAGGGDEEEGTQSSEEEEIVNYIGTVVVKYIDPPTSSVSTTRFPDEWERAEMKARGFFPIDRIELASCSTPSFSPADPGISIINLFTSAKGKAMLPGDVVEVLVTNSHGTQDANDVERLCKALHLDPCAWCELHRSPFVPEDNFPPWLPLQKPLMLGQLLSVYVDISSSSYLLQHSFFASLLRVYNDSKSSSASSTSTTPSPDPEKVRLLEACAFSEIGPQLLRSLSRSNAPLCYPSLVDVLEAFSFVNIPLDRVLEISGPLQTRKYSLANWIPATFPPSPLQLCMREVCAQRSANVPAATTVSADALQVADMFNRVAQEASGDDSNFFFGHTSHPLCCAARSMTRNPAASSPRGVYISFSLFGNSLFAQQLQAGCTALCNPAHTKSLHSGLFLIGCGTGIAPLIAAVTQLMLRRASSVAGSAPFSCWVFYGVRSKAELLYDETLKEALRTGAIAKYEYALSREDDRGKHGMYVTDLVKRNRLMVTDALQSAGQVFVCGPAKALQSVRELVKCDLLAEPDDDDSVQEQRLLLLEDQGRLNFNIWSTGNIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPB1</accession>
    <name>A0A088RPB1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">REH2</name>
        <name evidence="13" type="ORF">LPMP_202930</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698495.1">
        <property type="nucleotide sequence ID" value="XM_010700193.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22574503"/>
    <dbReference type="KEGG" id="lpan:LPMP_202930"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200035200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_202930"/>
    <dbReference type="eggNOG" id="KOG0920">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5600252at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002676">
        <property type="entry name" value="ATP-dependent DEAH-box RNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000500">
        <property type="entry name" value="ATP-dependent RNA helicase DHX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058737">
        <property type="entry name" value="DSRM_REH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF119">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26536">
        <property type="entry name" value="DSRM_REH2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="10">
        <location>
            <begin position="987"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="1386"/>
            <end position="1551"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="1643"/>
            <end position="1844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="479"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="669"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1305"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2218"/>
            <end position="2250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="689"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="2230"/>
            <end position="2250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIN97788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2250" mass="248046" checksum="049581E4B3692C83" modified="2014-11-26" version="1">MGAAGCTGAPTWLWAHGLSNTAKEAELLAAMHAEQMADLLGYHVFTLPSKQHKHAETARAAGRYASSPKDKDSGPSTEKRMAQWPLPLRRILTDEETEGGEWHLVNTTPSLRHYISSEHTLLSPCLLDPKSRLRIEALFARAPRGCPSFAQQLSVERVRTLTASSAADGGEEAMVARLVLSSQVTGIANPSTDLVASGKAMERATAVILACMHAELLLDAVGVAIFDDLAMQKAHAMAAWSYGRPAPLPGMRPKNPLHVHLPQPLKELVVRTAGNGRARTSSRSAEEDWFHRHNVVTEQSGSFVETVVGESTAVEDITAFLHTRGAMRAAAPFLQVAIGARVKSTVLLPLPDLYGIRGGVGIASNAPDANTLAAMHALDVLCMLRVPVKAETAMDIAWKRARRERVPDVPCESADVSTPSPPARRCTAKKLITQVAVVAAALSEDFASVDEEQTKSCNTVSTPTPSRCRVVKRARLATEASAPDDDLSKAEAKATLDSTPPKVSVHGTAKMADEERLAAVRAVVLKEFWDMQPDTPDGYIMVAPGVPEGSAVAAYAITSPRRMDKSAKRRVLDYLSTVGRRLDDVIVVRQALSEDETEGRPRHRCALKVPLPAVCGEARLALGEADTIADAENVACMHAELILDALGVCLYTDLVKQKRHAEACAQWGRWAPSGPGEEQSSSTASPPPLRREHPGSLHWERQKEQNKRRGHSLGKTQGVTKQWLAEEGDREKTARLRGSAETAKADAPTAEAAVVDAEAFEYVVESQLDTVSKYRVQYYLRYENLKATPVTFTSNMGHSVLLHVATWSLPMPARYGSETVEQKCLEYIVKGAASTRRDAELLSWMHAERTLDFLGIPLFPNLPKLQAYHAKRAQVEGRVAPALITGTTAPLPHPSEVPLKPLRLRMKRFNIDLTAPLPPCPSTDSEDDSCVTPGAWEAYVEACAAYVLAKQMAIKNCFYEEQRVPRTGDVVIDAALAEAEAKPVDPDARLRLAAYCLTTLKRFVPRYDSYLVGPMHHRITYATIPLPGFEYLLGRGVGHNKVVAQRRAAMHALAILRRVDESYDDKFPAVAAYVQKVNSDKKWKEDTQAVADGEFDLDTFSTLPLINADAESSLTKQEKHHLSRFSSLFVTQAAWYSKQHVFTVDGKKRAVCLYTVCFDLPPPEEHLLVRLLPREESEMAFTKPPSAGNLKLEMESVVATHPEANRVKTGAIFSACVSIVDEDGQKMTASCSGGGTRDNILSAYEKLFLMMEGQVPAMKSIVDLLKLNPYLLPELIPSLTIPDAVQQRMQACLQNQQDLSAAMPCSGGTASLTSHRKSLNESNERLTGGGGESCSTRTQQAADKETEESARLLEQLQRRITNPVYLEKFATRRAELSIAEHKHEILEAIRNNPVTIICGTTGCGKTTQVPQYILDEETLKGNGGRCSIIVTQPRRLSAVSIAQRVAAERLEPLEESTGYIIRFDARKGRHITFATSGLLLRVMQTDTLLDDYTHVIIDEIHERDMNSDFILMLLRQVLEKRRDIRIVLMSATLHAADFQAYFGGAPLIQVEGHVFPVKEYFLEDLVPFAREHNCFTPLLKEAACVAESSEHKGCNASAQPDIGVTHAPIVVSGEDCATACIPRSRYGFLEASTPVDYPTIQFAIEQALRMIDITDSSILVFLSGWDEIHKARDVLERNTSYYVLPLHSAVSAESQLKCFLPPPPGKIKIILSTNIAESGVTIDDVGVVIDTGRMKQLGYATRIRTLVPKSDPQGYDSNRVEDTPTVVSPSLVPEEAQGKFSRLMSTYASRANCVQRRGRVGRTRPGLCIRLFSREHFRSLHEFQTPELLRTPLDKLCLTILKLEVGAPQQFLKTAMEPPLESEVDCAMKRLYDLGATDEGGQLTPLGHRLAKLPVEPTIGKTILLGAAFRCLDTALTIAATTEKGVFTCSFDARVSSRLHREDLSCNTLSDILASVNGYNYWVSLLRERAHGQVAEQIRARQLSVPALIQATQLKRQYCNLLVDDNFIGEESRVPTSMHRRGFTSEDIVFIESSEHSRNSMDVGLSKCLLCSNALPKVAMVTGPQVLRTFFENYIAIMNDSVLKTSKLTQESNPFVIYDGLRKIPEKETLMAHHLTSVSLWSVLLMSTRATRTDYHHELKLGIVSGWIFFRSSYSTIELVRQFKALLDRRLSHKFDDPKDAVNNAQLDKLCEIVQELANMRYHPNRLQPQSVMWGEQGKMISPDSNVDGDAVKETSETELESSKASDVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPD7</accession>
    <name>A0A088RPD7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_201460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698347.1">
        <property type="nucleotide sequence ID" value="XM_010700045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPD7"/>
    <dbReference type="GeneID" id="22574355"/>
    <dbReference type="KEGG" id="lpan:LPMP_201460"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200019800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201460"/>
    <dbReference type="eggNOG" id="ENOG502SKPC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272796at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="262"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="324" mass="36390" checksum="034DE6714687AC10" modified="2014-11-26" version="1">MLRARRPAGPGRAPLSDLSSSSDNSRREPMLEGRPKRCRTPCQDEVAFKELQARKLDVQTRVRQQIEVLSGLESNVLDFYYTHMLRFEPLLEFVFHTPLSAATAPASVSNGVLGEGLTEVFPELKSTTALVGICDGCPPSLTREPVPIQPAAVPAKTRYYYNSALMRLYREVALQEKDLAQEYASETTRLAAAELSVQRDIIDGSLAGQLRIEQEEQEALNKLLEFLAGVTAQCAAYRQLVQAAGERIKGIEKAREACLARKTNLEAKKLEQMGNAERIKEEVAAYRRCVEVAATELEKRKLINRSLEDEIEKRRAAMKRRRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPP5</accession>
    <name>A0A088RPP5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12 13">Diphosphomevalonate decarboxylase</fullName>
            <ecNumber evidence="2 12 13">4.1.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LPMP_180020</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(R)-5-diphosphomevalonate + ATP = isopentenyl diphosphate + ADP + phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:23732"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57557"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="13">Steroid biosynthesis; cholesterol biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12 13">Belongs to the diphosphomevalonate decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.33" evidence="2 12 13"/>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697837.1">
        <property type="nucleotide sequence ID" value="XM_010699535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPP5"/>
    <dbReference type="GeneID" id="22573892"/>
    <dbReference type="KEGG" id="lpan:LPMP_180020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180005300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_180020"/>
    <dbReference type="eggNOG" id="KOG2833">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253702at2759"/>
    <dbReference type="UniPathway" id="UPA00063"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004163">
        <property type="term" value="F:diphosphomevalonate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000087">
        <property type="entry name" value="Diphosphomevalonate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000015">
        <property type="entry name" value="Diphosphomevalonate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005935">
        <property type="entry name" value="Mev_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029765">
        <property type="entry name" value="Mev_diP_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053859">
        <property type="entry name" value="MVD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041431">
        <property type="entry name" value="Mvd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01240">
        <property type="entry name" value="mevDPdecarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977:SF3">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18376">
        <property type="entry name" value="MDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22700">
        <property type="entry name" value="MVD-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015950">
        <property type="entry name" value="Mev_P_decrbx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0152">Cholesterol biosynthesis</keyword>
    <keyword evidence="13" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="3 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 12 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 12 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="7 13" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-1207">Sterol metabolism</keyword>
    <feature type="domain" description="Diphosphomevalonate decarboxylase-like N-terminal" evidence="15">
        <location>
            <begin position="21"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Mvd1 C-terminal" evidence="14">
        <location>
            <begin position="196"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR015950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF22700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AIN97184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="393" mass="43484" checksum="E4A3F34A2252383B" modified="2014-11-26" version="1">MESMQENFPPVPAPIRVTVEAPINIAFIKYWGKREGGEKLILPTNDSFSITLSTKPFRSKTSVELRRDATEDELWLNGKKSNIQETPRIQSVLSCIRANCPSHLKSLKAYIVSENNFPTAAGMASSASGYCALASALVKAYSATVDVSMLSRLGSGSACRSAYGGFVIWHRGEKPDGTDCIATQFVDEKYWPDMQVLCAVLKGEKKDVSSTTGMQQSLKTSPMMSDRIASVVPARMKAVKEAIQQRDFNKFAEIAMADSDDLQEICHTTAPCIQYATEDSYAMIRLIRAFNAKKGYNAMAYTFDAGANCFMFTLKKNLPEVVAMLCAHFPTSWEQMFFHDAALLEECKAYKLPTSFEGLINYPKRPLEMLLQSPVGQGVIHLDDAESLISPHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPY0</accession>
    <name>A0A088RPY0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Calpain-like cysteine peptidase, putative</fullName>
            <ecNumber evidence="4">3.4.22.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_205370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.-" evidence="4"/>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN98028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698735.1">
        <property type="nucleotide sequence ID" value="XM_010700433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPY0"/>
    <dbReference type="GeneID" id="22574749"/>
    <dbReference type="KEGG" id="lpan:LPMP_205370"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200060600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_205370"/>
    <dbReference type="eggNOG" id="KOG0045">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268518at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000058">
        <property type="entry name" value="Cysteine peptidase, Clan CA, family C2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015232">
        <property type="entry name" value="DUF1935"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036310">
        <property type="entry name" value="Smp-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF423">
        <property type="entry name" value="LEUCINE-RICH REPEAT PROTEIN (LRRP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09149">
        <property type="entry name" value="DUF1935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101601">
        <property type="entry name" value="Smp-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="3">
        <location>
            <begin position="175"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="418"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN98028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="689" mass="78545" checksum="CE95DFB5DE03FD34" modified="2014-11-26" version="1">MSMIAKSGKVDEFDEGSVVQKKYGPRDYRYGEPVYKGDATPCFDDGLLFRIVEKNNNRWSFYNDTTHTQMRVEFVFGCNSALRALENTKMEKLKNGSYRATVTVYPMETELFVEGQTNGFTSNIRALPLSEDYLKDMARQDYEFIKQETATLYNAVDKAATIDDMVRTCVQNKIKFVDFFFPPEQKSLQIGSLMKLKVLPWERPGMFLSDENARQARLFRNGVHPSNLDEGDLGDSWLTGAMGVLSEYPDKIRDIFRHPESVEQGQKERECGIYRVTLNKNGWWTSVIVDDYLPVAGGRPKFARSKGDPAELWPAILEKAYAKIFGGYGFIVAGDPLHALQDMSGFPCSSFDNAFVESTINETYELFTHLKNYSNLGYQIAFTTPTREAIMTARGAISCGTSTQAERAYEKANLLLGHTYSVIRVGYFEKYGLRLLHLRNPWSQTASDWNGPWNKRDANWNKYTEVADYFHFDSADDGTFFMEWPDMQDYFVGCGVCFIQSPMYDYRIRGTFFQNVPTTCMEISVRRPMVINIILSQDDKRGTDKGENAPIMISVAHGMGAMGPMRVDMNSGFDNDHPSPEYAFLQSRDVSMFYEFTPENSPYLVVPRAMSQFAKLPFTLGLLCPYEIGKETSEVRVAFRALAPENRIFDNFQKFNCETVATETEFQAKGPKQFFPDIYVGTIIQTSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPZ7</accession>
    <name>A0A088RPZ7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pumilio protein 2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PUF2</name>
        <name evidence="8" type="ORF">LPMP_181380</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697972.1">
        <property type="nucleotide sequence ID" value="XM_010699670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPZ7"/>
    <dbReference type="GeneID" id="22574028"/>
    <dbReference type="KEGG" id="lpan:LPMP_181380"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180016800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_181380"/>
    <dbReference type="eggNOG" id="KOG1488">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000004">
        <property type="entry name" value="Pumilio homolog 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF12">
        <property type="entry name" value="MATERNAL PROTEIN PUMILIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUM-HD" evidence="7">
        <location>
            <begin position="159"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="214"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="264"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="300"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="374"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="453"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="535"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="721"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="825"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="576"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="754"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN97319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="849" mass="93220" checksum="615AE80F3D7C27C5" modified="2014-11-26" version="1">MTANWTAAPDAHLRVEDIDWGSTECEDMFTSSADDLLVADPRAVRRAETAPMVLTIMGTGGSLCVGGFEEVNPDEEYRYTEEYHQLYYSKNPRDPRMLLPLTRRRHHLVREARAPGALAVPSGERPSVSSTNGAVGDRVGNGDSDCDATAAVPEASETLSSQALVKLYVDTFRPDWDYAQIKAHICTFCRDQDGSRLVQRLLEKPENIVPIFNEVIEAFGELATDVFGNYVLQKMFDVVPKVENDLSALQEIREARLLDRLTEKVRGHLLEYSVQTYGCRVMQKAVENMRAADRDAIIRELDGRVVDFVFDQNANHVVQKVVEVCPAGAQFVVDAFIPSLGELACHAYGCRVLQRTFEKCHDVEGVNIRPLMEAVLSRVNEFTVHQYGNYVVQHAMLNAPEDLRHRFVVQLTPQLYALSCSKFASNVAERIVTTATEEERDAIINELKKPLSDFQGGNYLVNMMQDTYANYVVQRFFEAVSATQRELISELVQPHIGTINQSVYGRHLLRKMVSNNILTNAFLLGQGIDVSGPDYGGNANNNGHRSGGHRGSTNNTDGTDNRHNGGGSTHASRNGNGRGNRAGRSGRGGNSHSNNQHSDGKSNALRGNDGSSPSSMLLLQPHLQLQQPLLSGYMPLPQQYQYGNPYGIPQLQQQQPQVTPQAFVYPTASAAPQLYQPQQAYMPQLTPSDFGAFPGAAAFPTPILQQQPASYALQYGTPMQQLTTMPPQQHPARRGDTQSPQVYVNGGYNGAGQAHQQQSPQNSGFFHSPTPPQPQPVFQGKSDLADATVATRKGGRSGKGNASAVSNNASYTNAVSGDKAGAFLTNNVTSNQQRAGYGNRRTQQQETGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQL2</accession>
    <name>A0A088RQL2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome b5 domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_211650</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Radial spoke stalk protein that binds heme under oxidizing conditions. Required for the coordinated beating of multiple cilia maybe by functioning in a redox signaling pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698950.1">
        <property type="nucleotide sequence ID" value="XM_010700648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQL2"/>
    <dbReference type="GeneID" id="22574987"/>
    <dbReference type="KEGG" id="lpan:LPMP_211650"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000006200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_211650"/>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="260091at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000027">
        <property type="entry name" value="TAX-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052320">
        <property type="entry name" value="Cytochrome_b5_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21281">
        <property type="entry name" value="CYTOCHROME B5 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21281:SF0">
        <property type="entry name" value="CYTOCHROME B5 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="10">
        <location>
            <begin position="5"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN98243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="221" mass="25315" checksum="208093C39919CDA6" modified="2014-11-26" version="1">MSRLYTAKEVRAHAFDDDAYVSLNGKVLDLTPLIAAYKASPKFAHLTKPLVQVAGTDISHWWDAEADDLRTCVDVTSGMRTYAMPLGRVLHMPTIYPDSNIDLNYDIPWWKDPQYIIGALTSRTRRIRIVNTLTGDETTLEVCAEETLEELLRERYLSINAHARSYTWTRLDPDPRELDMSRTLEENGIHDEADSFEDLGLNADYYIPAIHLYYNDDLTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQV1</accession>
    <name>A0A088RQV1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gamma-butyrobetaine hydroxylase-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_211620</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698947.1">
        <property type="nucleotide sequence ID" value="XM_010700645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQV1"/>
    <dbReference type="GeneID" id="22574984"/>
    <dbReference type="KEGG" id="lpan:LPMP_211620"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210020700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_211620"/>
    <dbReference type="eggNOG" id="ENOG502RZ9H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19707at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010376">
        <property type="entry name" value="GBBH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35303">
        <property type="entry name" value="OS02G0197800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35303:SF5">
        <property type="entry name" value="OS02G0197800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06155">
        <property type="entry name" value="GBBH-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-butyrobetaine hydroxylase-like N-terminal" evidence="4">
        <location>
            <begin position="208"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="142"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN98240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="318" mass="34647" checksum="A248D9B390798A5E" modified="2014-11-26" version="1">MNGVAHRTRAVTLPSCLRRRRTAASSPSLCLSQEHAACASAPARYLFTSSLLSKLGDSVASKVSQLAESVWLADEKLVTEPRRKFEPKRVANTSLAERLAAQRNVRRCLVPTSIKVDKSRQYVEFTWPEEAVEAMRSVSLKTHTPDVAESPKTSTGKSSSPAASSQVAGSATASVDHASARDQSSAPCPSPRLLCVPPGMPLRTRALAEYLRAYTPSTDGALGDKDIVIYGRRGIAIVKVIPVGNYALRFVFSDGHSGGIYSYEYLYYLTGPTTKYGLMRGYITELRQRRKSRDPPKRSPSIKYANLLAQNAATAAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RR19</accession>
    <name>A0A088RR19_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_220360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699037.1">
        <property type="nucleotide sequence ID" value="XM_010700735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RR19"/>
    <dbReference type="GeneID" id="22575082"/>
    <dbReference type="KEGG" id="lpan:LPMP_220360"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220008600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_220360"/>
    <dbReference type="eggNOG" id="ENOG502SIAA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266385at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="31758" checksum="5C04094225A1D2C9" modified="2014-11-26" version="1">MQFDHYRDGETRSILMKDSQSFLCALLAAKKQQANELFGSWDVKGKGYIAIAQLRPLLLSLFPAPSSVSEQDSGTTATHLSVSQVKTAYESVTGRPWPPRASLSTGSASAKQSHRHQDSMYAGPTLSEVHAIIDVLCGGEREPKVALTHCSRDGVGNASTRPFAGRKGPTPNTAPLTLTSSATESSTSAVPSLHHRSLTSDAGAAFLYGSIEAIYRSFCRAAASPGELEPDTLPIDAVHLERIAWNVQAQRLSVGEGHALHRLLAAKATTVDPTTAPPTSTGADAHLTLEAFVKLLCAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRH0</accession>
    <name>A0A088RRH0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_240480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98682.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699389.1">
        <property type="nucleotide sequence ID" value="XM_010701087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRH0"/>
    <dbReference type="GeneID" id="22575457"/>
    <dbReference type="KEGG" id="lpan:LPMP_240480"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240010700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_240480"/>
    <dbReference type="eggNOG" id="ENOG502SB8Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266132at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98682.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="781" mass="85270" checksum="D8076A7713DB4597" modified="2026-01-28" version="2">MEQQPQLPAVAQLLQQHQQQCTADTATSARNTNEEAFDSVRQAAVVMFKQRTKDLTRLAQVETQCQAIDAELRHAQMCVTKLVSQQATLDALVEEEQQRTRQRESQLQELHSALLQLDEEHQTNGKRQRSAEAAIGAATAFIRRFTNADGRLFQLLAKANVQTAGRSARELQRLLAEAQQGLVAAEAHREDLMCLPSFSLTAGASPSGDLSYTTAPSLTAVMSANVSTTGVSHALQEWVAKVDWAQHRELADVVQITQQLVAWLSTDGSTQEEGQKAAEVGGASCEWNLPRLSLPTCTEEAVTEEHWFGSPSLLSTTLQAATHSCSSEKVVAEEDGSHGTLQLKGYLMDIDGNMVPNGEAVQHVLQHHLLAPLQAILTYNAHLVAVCAQQHLQLPADAPLLADSVTETQQRWASLYEAWQQWREEVLKTQAATEAATAAETELDAAQATLCALQQHCEEQSHHYASREEEVANLKEAEIGHYTAAWSKGMRTLQAQRNSFCAVSDAISSLTKEVSVLSTALHDDSEQHAHETHALDIALAEQQEQLAVTRQRVAAAKERVAEMEKECAEAQRMQQLVRDQHEVLLSCATRCFQSSSGATGNNDEGTQIRQTASREVRERPAAQCATNVARTLLQSATKFSPTHAAWTERLVELASEADDAAGGDNSGALLTSSVSPFFASLMAHCGDGHAARSESDNKLVLDATAARLAMQDAVARLRLPSDLFLDDDVVDTGLLAQMPYIRTSIHAEHAIRASVEEHRLFMCDATAEISLLRSELATVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRV4</accession>
    <name>A0A088RRV4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_204810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698681.1">
        <property type="nucleotide sequence ID" value="XM_010700379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRV4"/>
    <dbReference type="GeneID" id="22574693"/>
    <dbReference type="KEGG" id="lpan:LPMP_204810"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200054800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_204810"/>
    <dbReference type="eggNOG" id="ENOG502SIHR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268029at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="575" mass="61906" checksum="705A7996519E8BE4" modified="2014-11-26" version="1">MDAAETGNTDVVELVSDHYFPSDTNEATYQQQQLRGNGNRDGGPSTQLGLTSTSGQELEGYIYSDAAVLDLQSHAWISVPSAAVRRRRWRLVNCMWEQNPPIAITITDLSLSVKPTQESLWVVPQEANASTTDALQQDSSFLQVPHEKASAKASESLRDEHVVTDGSVAAKDSHPLVMAPGSAGSWNITKWRLADAPYLHRGFTSDVFPSECRQLLEDLPMGTQMEDWSMFVVAATLSFYQRQAHEWATSWWTWCAELSGRGGILLPGWLTAPSAGATVDGNLLSVAGSVTTTATAAASAVLAPLLSVLYALSCLLRAGHHALAQLLSYETLLTLPAKDSIMWSLVTNDLWRLQMELMLLSIAFILLFVCALVVMRYRKYTETLESWEAEMTRHNAAEVAKWAAEMDLRQRVARTTTSAGVATGEPSTHANASGDSSSGLFKAPARASSASLSGCGSLRREPLAEMPREVLDSVSKCQDGSLWYVDSEGAASIVSSQRQLRESSDSGTSDASMPQFSGELLQDSFRGCGATADGGVDVVGGNATKPVRVSASLFLTEQEPSVATGDEWVVAGGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSB7</accession>
    <name>A0A088RSB7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_210330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698821.1">
        <property type="nucleotide sequence ID" value="XM_010700519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSB7"/>
    <dbReference type="GeneID" id="22574855"/>
    <dbReference type="KEGG" id="lpan:LPMP_210330"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210007900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_210330"/>
    <dbReference type="eggNOG" id="ENOG502SB26">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="261755at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="242" mass="25529" checksum="B7B85F82309BB462" modified="2014-11-26" version="1">MAFFASPWARWAATVQRRCKVSPSSSSTTRSRAHSNFCVGTAESKSFQVKPNIGVPVWKPSAKYRKCKLACWLSNNLLAIAAYQLALEVGLTAIFGGLLYAHKITAQGVCEGLAAYHYPFVDWIDVEGGVYTEPVCVGPFTLNAQKMTALHTGHNIASGILPLQVLLLVVMLLPLQHASRLLRHTASTTVGASRAASGVGGGNAAAAAAATTAPPTSVLSGPRRASYARAASPKKPPATRPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSG0</accession>
    <name>A0A088RSG0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydroxymethylglutaryl-CoA synthase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_242080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699547.1">
        <property type="nucleotide sequence ID" value="XM_010701245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSG0"/>
    <dbReference type="GeneID" id="22575617"/>
    <dbReference type="KEGG" id="lpan:LPMP_242080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240028100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_242080"/>
    <dbReference type="eggNOG" id="KOG1393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1269963at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004421">
        <property type="term" value="F:hydroxymethylglutaryl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00827">
        <property type="entry name" value="init_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000086">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl-CoA synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013528">
        <property type="entry name" value="HMG_CoA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323:SF2">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01154">
        <property type="entry name" value="HMG_CoA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase N-terminal" evidence="2">
        <location>
            <begin position="11"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="501" mass="55178" checksum="9CD0502AA4CD93AC" modified="2014-11-26" version="1">MMRSTPLSLAGVSGMAVYAPHCRVDLEQWCKWTGNNWDKVSSVVGQSFRITNHNENTYTMAANAVLRLIVNNKIDPTKIGFLGLGTESSSDNSAGAIIVKGMVDKGLHALNMPAISRHCEVPEFKHACLAGVYAMESATRFANADGGDRIAIAVASDIAEYALGSTGEQTQGAGATAMMLERDPKLFEVQLQYSGSASDYRGPDFRKPHRRHFMNLEEYTKSSANGKMADFPVFSGPYSTLVYQEEVTVAVEHMLARLQQSPGKYYDDVTALFFHRPYNMMPIQAMSFLYARGLARATSEEHKVHFAELCKQGKADPAAVVKELDVDPHYFQQIESGTDPKDAFPDTGKVAKVLRKDKKFIDLLEKKMSMGSPAMGNFGNLYTASLPCWLAAGFEEAYTRKLDIAGKPMVMVGYGSGDASMSIPIVPVPGWEKAAANINVSKALESPVCLDRAQYEALHTGAEKNDLAKDSRKMEFVIDRLGNRNEATFQDVGVEYYRYIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSJ2</accession>
    <name>A0A088RSJ2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">MICOS complex subunit MIC10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_210780</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MICOS complex subunit Mic10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698866.1">
        <property type="nucleotide sequence ID" value="XM_010700564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSJ2"/>
    <dbReference type="GeneID" id="22574900"/>
    <dbReference type="KEGG" id="lpan:LPMP_210780"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_210780"/>
    <dbReference type="eggNOG" id="ENOG502S6B0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="263676at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007512">
        <property type="entry name" value="Mic10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21304">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21304:SF0">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04418">
        <property type="entry name" value="DUF543"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN98159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="10053" checksum="047DC5ABB3006A3B" modified="2014-11-26" version="1">MGDSTIIDRDALTESQKWSYITDNTLKMMSFGFLCGGAISMVVFRSVAFRAAVTAFGTGCGIGKSYVDTKYILGHDIGAETVWSAQVAPLKSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSX5</accession>
    <name>A0A088RSX5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleoside triphosphate hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_252100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699780.1">
        <property type="nucleotide sequence ID" value="XM_010701478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSX5"/>
    <dbReference type="GeneID" id="22575858"/>
    <dbReference type="KEGG" id="lpan:LPMP_252100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250023100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_252100"/>
    <dbReference type="eggNOG" id="ENOG502QXKI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416765at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="302" mass="32937" checksum="83BD36EF00280F41" modified="2014-11-26" version="1">MQKATLQILREQDDVCSSCVLALLKDNADFQSLSKSEGEDILKRDNEDAEKLSDGIRIAIRKGILSGKPDVSPVTKLNVVGLSAQEVTDKIMAALPSKNGNVIVLQGLSGTGKGTTVSKLKDALPKCITWSNGNIFRSYTYLCNEVLSAQGKEITRENLTDELLSLVEKRITFLKCDDGIFRTMLDGTTRVEDVQNTLLKTPLINSKVPTVAQQTQGEVIRFGTGAVKQLSADGYNVILEGRSQTLDYISTPLRFELVIPDVAALGQRRAAQRVMAKALEMVANGTPDEEIRNVLQKAVEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RT52</accession>
    <name>A0A088RT52_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_262050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700024.1">
        <property type="nucleotide sequence ID" value="XM_010701722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RT52"/>
    <dbReference type="GeneID" id="22576108"/>
    <dbReference type="KEGG" id="lpan:LPMP_262050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260025200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_262050"/>
    <dbReference type="eggNOG" id="ENOG502SR25">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273075at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="113" mass="12725" checksum="55354B3F5FA93A05" modified="2014-11-26" version="1">MNVAALSRLIEGAPIMIDSVPVGIDYYAALQKAWSRAPERPPSLPPLAMVSDVNLHTIEEMLSGDSEGEELRPPVPLGLIITYFIEDWRDSGLYDIVRKREETLSQQPHKWKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RT82</accession>
    <name>A0A088RT82_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_262440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700064.1">
        <property type="nucleotide sequence ID" value="XM_010701762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RT82"/>
    <dbReference type="GeneID" id="22576147"/>
    <dbReference type="KEGG" id="lpan:LPMP_262440"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260029200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_262440"/>
    <dbReference type="eggNOG" id="ENOG502S4UB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269117at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="122" mass="13913" checksum="A902564546E5D588" modified="2014-11-26" version="1">MFHTAFLAASKRHLRLRCFQCTRLLPSEHFPKRSGPLNTLVCVGCKEMCFGCGLRQPRSSFSDAGSNICDRCLAKQHVAQENVYFRYPILTYRACPFSVEEARGELCQEAQQEKPPLPCMPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTJ4</accession>
    <name>A0A088RTJ4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Stealth protein CR2 conserved region 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_231240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the stealth family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699281.1">
        <property type="nucleotide sequence ID" value="XM_010700979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTJ4"/>
    <dbReference type="GeneID" id="22575329"/>
    <dbReference type="KEGG" id="lpan:LPMP_231240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230019500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_231240"/>
    <dbReference type="eggNOG" id="ENOG502TFYM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="263283at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047141">
        <property type="entry name" value="Stealth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021520">
        <property type="entry name" value="Stealth_CR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031357">
        <property type="entry name" value="Stealth_CR3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24045">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24045:SF0">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-1-PHOSPHOTRANSFERASE SUBUNITS ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11380">
        <property type="entry name" value="Stealth_CR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17102">
        <property type="entry name" value="Stealth_CR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Stealth protein CR2 conserved region 2" evidence="4">
        <location>
            <begin position="158"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Stealth protein CR3 conserved region 3" evidence="5">
        <location>
            <begin position="375"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="508"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="508"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN98574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="690" mass="77602" checksum="4BA744C0986D2347" modified="2014-11-26" version="1">MLYSPSGATERFCYSGAAGEGSNVEQEFLRVAASYVSSPYEGPAGAYYNFFAAHHATLWTVDAATRVATPMRLDVVYTFVNPTASSFRRNLEARHVPLEQRRYRDWEELRYSLRSLRQFVLASGAFAQYHHRHAADVQRLSELGYQVNVSDAGVVDGVVSLVRRVYLVLSDTDQMPAWLDTEKFPELRVVTHADMFSAEEAAWVLPTLNSNVIESGLHRIPGISRFFLYFNNDMIVGRQLSFFDLFRPLSPPRQILEMANLQQADGVADVKTAQPYSDDTRVALFFETIFNSDGYVPPPSRSTLARIGARLVPQSWCAHLADVRPTGGLADRALRLLCTPAKISRPEQRGDALNHFARYCVQEELPGIAPSIEYAHMPRTFDREVLRMFSDDPISGFGVAVKEMRKAYIRDMNSFSPVHIYESFALAMRRARTAALWCQSDVRCAASLRPMHPLTTRKWRQRRTASCPGHPLEGGSQAVRLQHSDMLARWNSYEEKWLSSITTLPTSATETSQGSLSRSGVSAQNTATPLSASAPKQLYEPSQVVRMLLSERTARAPHKVSYQMISGCQHGGPVDASRVQSLMLDVHHHVFVADLTFSFFIVEDFQRLAIILSHLEHIAGSGTAPRASTLPLFITVNDDLESGVLDKQLHENHLMGWNRSHLTHAAFRRLLWLCSYMAPQAPWELWPVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTL9</accession>
    <name>A0A088RTL9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA ligase k alpha, putative</fullName>
            <ecNumber evidence="8">6.5.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_261320</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="8"/>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699952.1">
        <property type="nucleotide sequence ID" value="XM_010701650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTL9"/>
    <dbReference type="GeneID" id="22576035"/>
    <dbReference type="KEGG" id="lpan:LPMP_261320"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260018100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_261320"/>
    <dbReference type="eggNOG" id="ENOG502RICY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="411785at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08041">
        <property type="entry name" value="OBF_kDNA_ligase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000375">
        <property type="entry name" value="DNA ligase k alpha, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029319">
        <property type="entry name" value="DNA_ligase_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025487">
        <property type="entry name" value="DUF4379"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050326">
        <property type="entry name" value="NAD_dep_DNA_ligaseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47810">
        <property type="entry name" value="DNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47810:SF1">
        <property type="entry name" value="DNA LIGASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14743">
        <property type="entry name" value="DNA_ligase_OB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14311">
        <property type="entry name" value="DUF4379"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="7">
        <location>
            <begin position="386"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="129"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN99245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="634" mass="69131" checksum="80487778760A0E83" modified="2014-11-26" version="1">MKATVLLRLGGGGGSGLIGRPTLLRRQTAKRVATTKAKGTTTGGRNKKATAPTADGGWCSHKLSLADFHPAIARTWIAAASNKMLQPQHVTPDSRKLAWWICPSCHHQHNKRIDRHLAAGGACPQCGAKPTLDVGRSARKDASSPRSASNAASLSTKTKRTTAASAQKSVPAVAVLRHRCRPSSTLDTIAAPNANLLSKSVADGQYLRVQETRNLLPMLAKSYDKERWKIASDEVLQVSPKLDGIRCVAAYRVDTKQVLFFSRSGTLFECCDDAIEPALRHLFEKDPTLVLDGELYNDSVNLVQLSTVRTAAGKSPRLSPTAALSEEDPVSAFYNSLLAAAYGNKKHKHNSVAAAGVAQTDLPAVIRFDQLTSAIRTTRQWLTPEVSALQRQLQYHVFDILYSREFPGGRGSAVPFSVRYGVLERLLASVTVHNLAHISRYDPLVLRRVPSYLCTIDAVDTVLHAAMRVGYEGIMIRRECRGATTVADRDRNKKLESAIKKIKRGSASNEGKARAGAATENSDGGYGYGQRSSTLLKYKVMQDAEYVIVGAVEGSGKWKGFLGSFICVTPDKKHRFTVTPASTDAEKRRMWQSWKTAYKGKVLTVQYQEITPDGVPRFPVGKCVRGAADGHDWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUC8</accession>
    <name>A0A088RUC8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA polymerase II-associated protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_272390</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the RPAP3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700325.1">
        <property type="nucleotide sequence ID" value="XM_010702023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUC8"/>
    <dbReference type="GeneID" id="22576417"/>
    <dbReference type="KEGG" id="lpan:LPMP_272390"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270032300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_272390"/>
    <dbReference type="eggNOG" id="KOG4648">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="629492at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101031">
        <property type="term" value="C:protein folding chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051966">
        <property type="entry name" value="RPAP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025986">
        <property type="entry name" value="RPAP3-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46423">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46423:SF1">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13877">
        <property type="entry name" value="RPAP3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="160"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-polymerase II-associated protein 3-like C-terminal" evidence="8">
        <location>
            <begin position="370"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="283"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="321"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN99618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="487" mass="53296" checksum="B7DFB575B1A84813" modified="2014-11-26" version="1">MDRSVAEAIRQQSEDLRDELKELEQWEDAMQAREVARTQRKVPLSANAAVAEPPIRGTVPSLKGAIQQQQARAASAGGDTAARAVVDPIQQAKDKGNALFQSGYLSEAVAAYTVGIDLDPASATTHVLYANRAMCYLKLGQWTAAEKDATTCVHMNTRYVKAYYRRAVARKQLGKLHEARADLEAVLALAPKDVSAQQEMESVTRALQATRAAASQASATAGTSAKKRIIIEEVDSEDDEAAGEAPVTSVSKLSAEEEGLRQACIEEDLRRLAAARESREVQARQEAQREAAAQAQRQRRHERVEIIEEEEKSSTEEKKTASSPAAATPAVKQTPSSVTSSPPASSSPSPTSATTRARPRPSIAKESLTAPKSFSEFERRFREVGQQPELRDYYVRQLNPATMANLFGSNMTPEMLLGILQAVKTFHSTVALQYARGLCQVRRVEDLTLFLNAQEKAVVQDVLDLLRSAPDIPAKDIEHIERKLKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RV44</accession>
    <name>A0A088RV44_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_281420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700482.1">
        <property type="nucleotide sequence ID" value="XM_010702180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RV44"/>
    <dbReference type="GeneID" id="22576587"/>
    <dbReference type="KEGG" id="lpan:LPMP_281420"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280020200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_281420"/>
    <dbReference type="eggNOG" id="ENOG502SKJB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264226at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="35349" checksum="8F6C0B78B60EA946" modified="2014-11-26" version="1">MTEHRQLFSERAGLLPAPTTSPKRHASSIKSASDFPSVSVRVTSASSAATSPPYIDDRAWLFHTALLPPIRKSAFGRDGSGQQHPSSATQEKPARLIVRDDVPPVEPPKLEPQAGSSVEAEPPPVLCMEPNRLFFSDAPSPSGVGESLADRYSLRTLYTSRCSSLGMRCPLDCLLRQLPSEAGQGAADELRMLVLRDTYVPAKACQALTVLLPYCTGLEYIDLSNAGLRSKSGFMTGVNALLDALIFGVENHGVGAALHTIDVSFNKLSDRTGWRLVRLVQRQPHLRVVNTDGTEISDRVKTRIDEELHSSLKASVPPMLLGEADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RV91</accession>
    <name>A0A088RV91_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glucosamine 6-phosphate N-acetyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_283170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="2.3.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acetyltransferase family. GNA1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.4" evidence="6"/>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700655.1">
        <property type="nucleotide sequence ID" value="XM_010702353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RV91"/>
    <dbReference type="GeneID" id="22576762"/>
    <dbReference type="KEGG" id="lpan:LPMP_283170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280038800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_283170"/>
    <dbReference type="eggNOG" id="KOG3396">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10039976at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000105">
        <property type="entry name" value="Glucosamine 6-phosphate N-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355:SF11">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="7">
        <location>
            <begin position="5"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN99948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="148" mass="16266" checksum="FE6B2B80756730CD" modified="2014-11-26" version="1">MSGSIVIRDLETRDLGEVLALLSHLTSTPVLSQEELEQVHARRVLAGVRTRVAVDSTTQQILGTASLIVEPKFIRGGKCVGHVEDVVTHPDRRGQGIGRKLLSNLVEIAGASNCYKVILDCTDDMVAYYCKAGFRKCENQMRLNIDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVB9</accession>
    <name>A0A088RVB9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclin dependent kinase-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_282370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700577.1">
        <property type="nucleotide sequence ID" value="XM_010702275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVB9"/>
    <dbReference type="GeneID" id="22576682"/>
    <dbReference type="KEGG" id="lpan:LPMP_282370"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280029900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_282370"/>
    <dbReference type="eggNOG" id="KOG4164">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5353095at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012388">
        <property type="entry name" value="CABLES1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22896">
        <property type="entry name" value="CDK5 AND ABL1 ENZYME SUBSTRATE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22896:SF0">
        <property type="entry name" value="CYCLIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="402"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="476"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="577"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="906" mass="97854" checksum="4D1C571078222235" modified="2014-11-26" version="1">MSVQRATAFLSAISPTELHPHPLRGTARSSAQKDSGSNSNSHSDSLGGSFNNIETKEEGAVLDGMSRALGPGTGSSGVLRNFTIHVPNTGGLVAPANIRVGGLASAATQSTSAPSAASITSGNDPDAPVTLDAVSTARAHFSRSICGASVSKAVSQVTPQQLQHRRRQPFAADASFRNRRQESFLKSLGNSMKPVKRRRRHNSSSSSSSSSSSRSESRRSATSLVNSGVTAVCGLGAGAGGVRQDAGTSAANPGVTAADRDLSGTTLSGGATVPGGESNLPPPQGHRRRVSGNNGGKPPLQVHDLVKREGQRVRLRWIYSDVQQHRSSSSSSSSSPLSRRSSSSPQGRGKRSPKYVPGGGDGTAEVKGSLAASGAGQPPDPLEGEWSGTPQHLSSVSHTLMPLLSLSSSSSSPSSDGNSRRCRTRSKRRWQRQCWAQLAATPLSLCTILTKFEPCVTSVWKENQVIQPYRGESNASSSRSSSSSKKRSSSSSSSSSSSSSPSHSWDCNELTCEYQDFVVNSQYLAGNYADRRHVAEMTSVAGSSRSSDAGLKIHSLYLSLSSKAHSDSGTHSCRGCGSRTQSDSSSSHGSSCSSSRRNRGSSRSSRSHSSRSSRSSSRGSLNVRHRRHHHSRGKGGIISGEGDIRSYRKVLARQQCRNNPAFLNAYFLDTGNITGGERRRKMISLPSYRVSMISFVDKKILKKDLNHNFYIQHPGLEVRDIKLTHLRKIKHELLVYALEDNSLLDLTTTAYAYWYFERLVVQGMVGKHNRKEIMAACVLLAIKFLETGDLMKKIAYFKNRWRRFHNVSGVHVGNVNAMLGGGGAKGVEEDDEEVVHVDWKKVEEQEFPVYVGLDFTLLPGGDGQVIKTHIERLLQLINVTSQEYYSKKFVSPAYLNHYNCYSNLYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVG3</accession>
    <name>A0A088RVG3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA replication initiation factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_261210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699941.1">
        <property type="nucleotide sequence ID" value="XM_010701639.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22576024"/>
    <dbReference type="KEGG" id="lpan:LPMP_261210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260017000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_261210"/>
    <dbReference type="eggNOG" id="ENOG502S6JK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="251770at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00027">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13561">
        <property type="entry name" value="DNA REPLICATION REGULATOR DPB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13561:SF20">
        <property type="entry name" value="DNA TOPOISOMERASE 2-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="420"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="500"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="816"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1035"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1216"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1407"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1674"/>
            <end position="1728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1740"/>
            <end position="1782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1821"/>
            <end position="1893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1920"/>
            <end position="1971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2085"/>
            <end position="2218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2280"/>
            <end position="2357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2490"/>
            <end position="2516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2652"/>
            <end position="2673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2862"/>
            <end position="2904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="516"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="820"/>
            <end position="829"/>
        </location>
    </feature>
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        <location>
            <begin position="1054"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1221"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1771"/>
            <end position="1782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1828"/>
            <end position="1846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1882"/>
            <end position="1892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1954"/>
            <end position="1967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2280"/>
            <end position="2290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="2335"/>
            <end position="2350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="3073" mass="327365" checksum="999F516108C2A3DB" modified="2014-11-26" version="1">MTDHTQPLPSLTKAFAAMRPNLVTHKNHQLDRTELQRRTNNAEEDAQTTRESLVHERSHDTAHTGDISLSSFSSAEAAAGPTCLISFTGFRDEDVWGGNDAEGNDAGHDPLAHAAGGDAAPYANALSVCHKMASALPRVRVESKLTSSTNVLVARRGFTKKRLLAARQGIPVVLPKWVVMGCPALPTGNGITTTTATASASSYDLYAVPWLHGYVFSTTGLSTSEKAAIGSVCAAHGAVVEASLTYKCDVLLASAECVRALHQVLHADGAGDAAKRSRNQHLHHAEVQRTDAGLKECSGTEMLTLGKGGSVPHAAWLTDKVRFALELDIPVVDYVKLFAMLRLNRLPPPTWTPGPAVLLPKSSWKTRGPCDDDMENKNRYADALNGSDFDEIVHVCRVGAPAGGSAEWARILSVFTNAGGSSTAGRGPQRDEGAADQGPENMGLSAPLNGIALREGSMQSSSSSFTDSASTVSDPDLWESLLSRALVPSFDEPPIRGVETYPEVSGMPDPTDAADHLTGTTHATTTASPSSQAAWDKPAVSTADVEDFANARTEEPSTLHVSLPDYYSAATGPELAPYSSSQWGYARQEVLTTTEDPSWGTTTVDPSPRLTTNALLHREAAPPRQLRHTSEPLACAQPDRAESVALRQRTAAYYEMRRSSDRLPAQLPARDAVAISREAAPLHAPAGSPGYSLVALSQTTMVGGAPLAATQVLVESCVSAGELELASMQQVDAHQTSAFRATAARQALPLFAMHPPYLTICVLGCTELELRKTARWSEQCRLLRSPVPTSTTDIVLLGSRILTKKRYTMSYAADSVNDESSAKGGEKQRQQRPTRHRNPLSARSGGKNRHRRDHAGGGVTVAIRYWEMDAAVARTLADVCGVPLSRMAPLKWLEDAASEAKKACEKAMLAEESVAAQRSASHALAVDSDESCTDTCWMTATTPPDKLVGLLEEHLAAAAAAAAESEERVALHQRQLFHPLPPLSPEQLPDMADPKYFIRVRQAAATLWASNAAPLVAQRSHNISAGASLAGLEVEKQAKRSERHHHAQQAAGGSATQPASDSATLLTRNEKSAADRAPVEGDDSLTAAASRSVDLVPAISMSTVQLGVRKATSLSTEDEQHSYEAALATAERRFNQLVALFRVSGDDGNIARVMNVGAAEDDRQGHSKALEACHFCCVEGEYARVDWAVVRGLIRYGGGRVEKRAADDWQTLLQQQQQQQPRVTATATNSDVQQDQQDQHFTRALRWSVEYTKLRQKLLRVMRDVELSHDVSDQTRAGTLPGCASAERENAAEIARLTAKLQRVSLLCQQAPVLCLCPHSFQRPAADERGMAATADATVRHMKGLPGRAAVGPASPCKRLHALHRLPAVTMDYVLACVAVGYCLSPHSCFLFDVSIPSAPDMRLFQRQHQRQGGGGAPSQKASARHTGSKLGLGLIGSNTPEGSNDEAGKRLQPGAVSAGNGCIGRGKAPLHRPALSSWVLERRYTKTDSVGVCISFLWRLPTPPASESERCWSRVDMASPPAKSAAVVPSLTPDASLVPLLRVLLLGLRNAAEALGGHVVDTFSPSAVTHVVSVDIGGILSGTLRDAFTCDVVEKTSAVTGSGGGDRPFPYWPVYSVESIARYAARDEVSLVGLEWLAACVEWGVFVDEAAYAPPPDLLALVQAEKQKALLASAQAARTKQHRRAAQVQKRQPPRQSLNHCHLTQHRAHVAAPPPADPALPGALVPPAARPVSHLEWHWKRTGTPPRGGSDTAAPHTPPPPRLVDYDSPPNRDDEEKEEHECCTPVIRGILSASTTWCDSSAGLCTPPVREAPLPDNVVRRCQQSPPLQPLSSPVPPPPPRPQTLPDPDSSSQCMNFRARSAGTPSIGDHAHHYQHRRRSSPSASQQNTRSLLEEKEAEAYVEHLGSLFNFFSPGSTPLPSSARRCGERSTARYADADASTPRRLRSPFLPHTLSQSHPPNVTSSPRAPHSRCELMHERGMPRTSSSLLHTQALTPSKTSAALQMTGAEKTSSAVGLSNALSTPRRRTLRGAAAVCISSATKKSTLSSPDRQHRRTENFAVAVSSSVTNLQVWTAVAGVGDAPCDVESDAPDANAPPPQPLVLPSLLGGSTELSRDGTVDAKPVGDSSTASICEEVDTKQRQRQDGGCTESMWVSQTPNALTPEGKKQRSNGAATGTAPQHRAHKRGRVTGGQRDGSRASASVSWMHDASLESPQQKPQDIAVVECVDVEPMSGEVLVDATFIAATPEAYGATPAATSEASVGERHCKAAATLVLAGDREEVEHEDETKGVPPGPDVVDAAHNPLILRPPSTTATASPLAQKAMRPRLASCSAPRPPSPSPYSPPPPPRRMAMDGDGGASIVANVAEEEHQCGTPCAYTDSNAPALSSWTRHRPLSISSRPSRSPPLVSSPLHMEPTALVTGTAVAVLPRTTVATSCRWDCLRIYALHDLPLRTARVRRCEEALETFMRHCGGVMPRSYIDIGLRTAEPPAKDSDQCGGVGVGSDSTRSSPTSQPTPPLFFVSRCEDADVLVTHQVNLRESVLVGVAGGCWVVRPGFLECVVAVLDGACWSGNRSTANSMRGQRHLTHPSAAAAASVFCALRLREALPTYEWTAEALPRVPALGCPPESNSVTPMQRALAQQCRRQRERRERAAGADVVNGDAEQTSTASRPSERIFEGNSFVLCCSFSANAVPAGGTSAERCRTSSRVRAIERVLETGGGCLCCSVQVGCAPAEIGVKTDEITGAVATATHVPPIVQPPLQCCVWAPSPPKQGNRRLQRDFAHTSSPLVMDAALYHDLLWLICNQVRQMPSETLFVLLDESLLGSNTDDAQGGTVVCVSPAPRTTVAGATAAAARLNGKDAGNEDLLTTPPLSEHHHASKKRRTENVEAHNSPQPTTASVPEAASVAAGALASSDTCTVAAWLSSWLLPSPDDGRCSKAMDGRPPCHRGYAPAAAHAMRAHLGACCAAVRGAADEIRGSTCTSGSYHLADVPFDVPSVEEVRQACTDGEGGTKAGSTMSASRGVVRRIEFRSTSWVGACVAAGGSAMMAAATEAWMVEWEAHTRWGVLSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVK3</accession>
    <name>A0A088RVK3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_290050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIN99955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700898.1">
        <property type="nucleotide sequence ID" value="XM_010702596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVK3"/>
    <dbReference type="GeneID" id="22576769"/>
    <dbReference type="KEGG" id="lpan:LPMP_290050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290005500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_290050"/>
    <dbReference type="eggNOG" id="ENOG502SHSY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272593at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="677" mass="73713" checksum="61B8B888F5954416" modified="2014-11-26" version="1">MCVSQMRRPEPWQRLLSHVRHTIATPFILRIGTGPPGSAPPLAVATHPPSALPTIATNYCELSAFEKDYAARCLEYVANQQDDTQAEESDSIVDTTSSFSVAPVFPTDERAATWRPLFDLLVLPDGSVCVGWLRHHALDVWWGHHVAAYVADLWQKSPRTLWLHCREKLNRLVRRQLPMRHRHLSVFQPNDTVSTAETEKSLQAAVRSLHVATSSAYQLERDVLLHTSNSGKPTLLYVRALMHDIERRDRELPTGTAIALMRLLVWTFAMYYDSMPRDLAEAIVTSAGHICDLASDSGCHQLLTWGALLVGCTDVHSKGPSELVHADAATQALTLTLLSSIDMPGHGREAALRWQAEQHLHPLCDALVSEEALLLDALAAFGSDAKNAEDRAAFSSRGSAGDGLVDVDAKNSTTVRGDVVASHFSRALDQKLGEAEDEGVLRWDPVRESGQLPLAWLPGTGTDAKGCWCTLLTHSTILLSHGEASDHTASSNTASRYAAAVKRVHCMLRIALVRRCLFSTTDANISSQYSIVTHLFSSAEAHLARLTLIHLAATDVLREVIDPEAPQRALMGFLFLFPSLSLRSVYGGTVACAQASLSAGACTLQCSSCLDSSQTSAAQDTSLTVRIPATCAKSLASRLAGRDSALICVVQRVPDDPTAAFLLEDLYMHLYAILPCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWD3</accession>
    <name>A0A088RWD3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_292640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700868.1">
        <property type="nucleotide sequence ID" value="XM_010702566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWD3"/>
    <dbReference type="GeneID" id="22577027"/>
    <dbReference type="KEGG" id="lpan:LPMP_292640"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290028900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_292640"/>
    <dbReference type="eggNOG" id="ENOG502RZ1M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="422827at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="3">
        <location>
            <begin position="50"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="789"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1066"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="791"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1071"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1081"/>
            <end position="1090"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO00211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1238" mass="134108" checksum="D6162EEA55A72187" modified="2014-11-26" version="1">MPPSLSSHPLTIVAAAAGVVTGTAVFAWGILHWDRRQQRHEGPDSPDSSWTAQQVAAWLRENGVSKSSVMLCCRYRVDGDTLMRLTAQDLYHMSVPLRDARMILAAIEDIRNCPVILSSVLPRSVSRRRSSPSLRGAQLAVPSSAEQFEAAWRALVRTCTLPANNASPAEQQQRLAVYTGTLLESFQVLTVSEQAAALSLVAAAEKVRVFPSGNMSREVHPAPLSTDTPTDTSFSMEAMEEKLKPLHGMLDGFLDFLRSPDLDAVAPAEFEELGERVAAQVKRVLRVAEQLPPELKSLLRRKCDDVFEALSNRQRTMPGASGSKAPDRATLMQALRNVLSVVEDPALRALPTAQRMQVLSSLAKKAEAIEAIVAGSVSHAPKDAEVLSTVQSLLRIIQEETRSSQRQAEADAQPAADEEGEEEKVPAAEDADATGGSISVIVATVQDVQATLQSEAFQCAPAAAKVELCTSLLQRVTALEDNLAALPPPAQAMVRDLLLNTKKVLAVMMATAESEGGHGAEDLPAEDEADEEEQDSDGDAEAAQAEREKSERANSSTGIEASVAQLERIFDFLTSDSLGKATVRERQQVASKLLQRVEAIKVDVAAHDTQGTLIRELIGPLEELLFDMAGNHSASPEFLEITAPLRDVQLLLTSDSYRQLPRSEKLRIAGKVLPQLHQLTSSFSSLSDSERVAAEALVQPINEELLRLSRRCDPATGSAQEVLNRLQAVMRSIQGAEFTAMLPAERSSWATNTVAELDQLRDCCVTLGAKGEEVLPLIERLRNQLSGLLPDRSDAEGDEGHGDSCDGVHVSDGDNGEAQQKQEGKPVDLVWGAVRDSRAELLATERTATSLPPERLKRMLRVMSEAAELPGMSAQQEAALQEFGNLLRRHVEAMTGQVNDGGGGAKVADAESDCDEGNAALHALRRSLQMLMDEVHGENKATTAELSVVARKTEELISGADAANINWRGDSQCARAMRSILEALQQLRGSEDGASGARVPSKVESVLQSSLEGLIVNPPTSMEDFAPYIRVLELTQSSAEQLTNRELMQLKRLQEAVIKAMQQLPELPPPNREKYGPKADDEAEEGCNDEEVDRVEAVFDTLRQMSYKLREGPFSAEELDEFEKVQEDLARFLADEGVDVGDSIKAVREQIRLQREALTNGEAGDEEELELAGNEEDDIDVLQSELQCAEQQALDSLPAEGTDAFNEDDDDGVCSNGAAVISGLSPGYVQHATGGERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWS8</accession>
    <name>A0A088RWS8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA processing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_310210</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701413.1">
        <property type="nucleotide sequence ID" value="XM_010703111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWS8"/>
    <dbReference type="GeneID" id="22577447"/>
    <dbReference type="KEGG" id="lpan:LPMP_310210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310007100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_310210"/>
    <dbReference type="eggNOG" id="KOG2749">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="258143at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1030:FF:000006">
        <property type="entry name" value="Hypothetical_protein_-_conserved"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1030">
        <property type="entry name" value="Clp1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032324">
        <property type="entry name" value="Clp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038239">
        <property type="entry name" value="Clp1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF7">
        <property type="entry name" value="POLYRIBONUCLEOTIDE 5'-HYDROXYL-KINASE CLP1 P-LOOP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16573">
        <property type="entry name" value="CLP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clp1 N-terminal" evidence="4">
        <location>
            <begin position="46"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 P-loop" evidence="5">
        <location>
            <begin position="136"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="254"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO00613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="522" mass="57318" checksum="ED46BACA221282C4" modified="2014-11-26" version="1">MVALEREYVLGPFCELRIITSLSSTQLSKVTLRKPVDEDGASTATRAEVFGTELIPGVPVHLPPGRSLSIFTSTGCTLLLVAPPAVLQRCYATSLGATWVRSVLDFHSHLERARVEARGREDVGPRVLFVSDRHHCGASTYVRWLSNFAVRLGYHPLLLDGVLDTPAFAFPGSMALFHAQHCMDIEEEMNLTPALYVQVGQSRVANPRLYQHWVQQLLPHGMEKMARSERCRVGGLFFDYGVVEPHAVEQAEMAAAAAHSSNDPTASASPAPSALGSDKTQTNPLDTLLDTIVAADIDHVCVVGSSWLRWKVVQRAWERFGGERSMDIVHAMLDPRWSVPQEVGCGGGQHFRLFLVDTVGLVRSVPVTLWKRQRWLQYFFGTPTSPVKPTLVTLEASQVRIATVGAAAIDTMSTLLPMMDSEDADRQKADVAAVSFITLQDVALKDRIVALSTATEYERGPDGELHSLSFSVFERSIRQGTVLGFALVESVTPERLTLLVSGCPLDKELGLCFLLTEEELKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWU6</accession>
    <name>A0A088RWU6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GPI mannosyltransferase 1</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">GPI mannosyltransferase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">GPI14</name>
        <name evidence="12" type="ORF">LPMP_301980</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic subunit of the glycosylphosphatidylinositol-mannosyltransferase I complex which catalyzes the transfer of the first mannose, via an alpha-1,4 bond from a dolichol-phosphate-mannose (Dol-P-Man) to the glucosaminyl acyl phosphatidylinositol (GlcN-(acyl)PI) intermediate to generate alpha-D-Man-(1-&gt;4)-alpha-D-GlcN-(1-&gt;6)-(1-radyl,2-acyl-sn-glycero-3-phospho)-2-acyl-inositol and participates in the sixth step of the glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the PIGM family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701221.1">
        <property type="nucleotide sequence ID" value="XM_010702919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWU6"/>
    <dbReference type="GeneID" id="22577251"/>
    <dbReference type="KEGG" id="lpan:LPMP_301980"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300024000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_301980"/>
    <dbReference type="eggNOG" id="KOG3893">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1741594at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990529">
        <property type="term" value="C:glycosylphosphatidylinositol-mannosyltransferase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051751">
        <property type="term" value="F:alpha-1,4-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007704">
        <property type="entry name" value="PIG-M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886:SF0">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886">
        <property type="entry name" value="PIG-M MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05007">
        <property type="entry name" value="Mannosyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 11 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 11" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="73"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="160"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIO00421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="432" mass="49695" checksum="F00E5E1DB1C7512B" modified="2014-11-26" version="1">MSKATWLDRQSIRQLLLYGGLVRLVLLIYAAFHDYYFRVQYTDIDYMIVVDGARELLHGGTPFDRTTYRYTPLLAVLVLPAVLIANPLGKVVFTLSDLGAAYYCFRILLRFSTERSAKWMVIIMILFNPVVLNVSTRGNSDMLISFMCMGVLAKFAEGRYFTAAAILGFAVHFKIYPIIYTLPLVLGVWERAKQNRFFSRLAHTTSVVVGCGLCFTVSFAVPTYVCYAVYGQQYLDEAFIYHIHREDHRHNFSPYWLLMYLNMGRRDLGVGVDYSAGLFAFLPQFAVLCYASWKLRKNIAHACCVETILFVAFNKVCTVQYFVWFLPFLAFVFCDPARSTGLTYATAAPKSERRRPLWSVMVIFMWGLTIPLWVWTAYPLEFQGRNHYGRLWIVSCLFYLATVGLAAWLGRLCYRNSMTIAMMDVSLTRKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXB1</accession>
    <name>A0A088RXB1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">9,11-endoperoxide prostaglandin H2 reductase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Prostaglandin F2-alpha synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">PGFS</name>
        <name evidence="20" type="ORF">LPMP_312000</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>prostaglandin F2alpha + NADP(+) = prostaglandin H2 + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45312"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57404"/>
            <dbReference type="ChEBI" id="CHEBI:57405"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; prostaglandin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701588.1">
        <property type="nucleotide sequence ID" value="XM_010703286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXB1"/>
    <dbReference type="GeneID" id="22577626"/>
    <dbReference type="KEGG" id="lpan:LPMP_312000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310026900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_312000"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000015">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="10 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0643">Prostaglandin biosynthesis</keyword>
    <keyword evidence="5" id="KW-0644">Prostaglandin metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="19">
        <location>
            <begin position="23"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="16">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="18">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00067802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00079905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="AIO00788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="284" mass="31871" checksum="6FE539250F7B7207" modified="2014-11-26" version="1">MTNVGKTAVTLSNGVNMPQFGLGVWQSPAGEATENAVKWALQAGYRHIDTAAIYKNEESVGAGLRASGVPREEVFITTKLWNTEHGYESTLAAFEESRKRLGVQYIDLYLIHWPRGNAILLKEGKKYLDSWRAFERLYADKKVRAIGVSNFNIHHLEDVLAMCSVPPMVNQVELHPLNNQAELRAFCDAKGIKVEAWSPLGQGNLVTHPLLITIGEKYKKTAAQVMLRWDIQHNLITIPKSVHKERVEENANIFDFELSAEDMANIDALNSNVRYGPNPDEAQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXS7</accession>
    <name>A0A088RXS7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_291290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700737.1">
        <property type="nucleotide sequence ID" value="XM_010702435.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22576893"/>
    <dbReference type="KEGG" id="lpan:LPMP_291290"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290017100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_291290"/>
    <dbReference type="eggNOG" id="ENOG502SJNI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267710at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="679"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="764"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="914"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1026"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1439"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1599"/>
            <end position="1619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1654"/>
            <end position="1706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1797"/>
            <end position="1816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="681"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="920"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="983"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1026"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1441"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1671"/>
            <end position="1687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1694"/>
            <end position="1706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1962" mass="207748" checksum="6C53CC8EC42C5A24" modified="2014-11-26" version="1">MPSTYAHEPDIRTLVAITRCVSAMQHSEVQSCAALFTDTHHALTCSSCTSHARALREVTPACYASGTREPLPDKQRSATMRRNGWPHVARSAPVFEVSPLPPPPTSSRHTAHQESSAFLSSRRLAGESVRAGEYVLEIGSDRNASDARYGGAHHTQSAASRAYGSFGFPQDDRHSIKRSTGVRGIHFRSSDDPGASRAASRVPLGGTAARADLPFSMRLSHLHRQPPSPSRSEADGATSGFNAHSLRLNISADVENKSSRASRSDDFTLFSLGISKVNGVSRISRADPASFMDEMCTASHLNLAQASTTRNSSHATVQPQLDCWEQHASSRSSRWMTSQGGEGSLVSPLQKLVHHGSAAPSVAASRSPPSVTAAVARNGRSVTSYDTEALWSSVRSAGAHAPPQSSRASAASRSSYPVSSLEHGGRRRASDTTSVRCSSHTQETATAVAGSSVPRILSHASLPVAVVATADDCTLDARRHLSDAVHDSSSLPRDPQHEGAEQLGFPSPVSALSHVASPLQILRSGTRCIHNSTTVLTCDTPPQPACAPRNAGELCLVNTTSSPRKQRHPADRGTDVVSVSALGASLDHTQCATHAASGELLSADRAPSHPAVSSPDLERCPLLEVSTRLLSASSLAFTASETSPVSLTSRSLRFSPPSAATVAVPDGVCVVEACPSQKSAQTREGKHVRHEAASHTSAASFRASASASASISTSAKSSLFLAEASTMRPDVLSRPAVASASAARRQYPPSSPLPSACFEPSSFADLQRAGGSPQRSLSLHSSCGAEPGSERREDGPLAPPVRTRSPSYSIPRRRRSSLKGAAAVSNMAERAAQSLASTVMGTCDVARLVQSTADENWRIQSNPTGLLGRGGEVLSDVIQRPHTTPPPESIGTADEPLTAVSEVEDDVAREEGIHTSANASSGFSREGSEEGQGWQQQQQPQQRHRFLGYVPPVRGPGASPLNQRSVAAAATHRGKAPLPLPTSPTSSATALRPPLAYCGNRGRRFCGGSGDNTSAGLPTNNARREVHEAASRSRDACPCCSPRASNRKMEHLSRGEATTTPTETPEHPRLSSYLPSLVDASGDERDTGTGSAAVIVHLDSRDAPSLAGDVIMMPTSPTMRSGAVRLISPARSHAAVTSLRESEEGRVSYRRRGCDELQVGDLDSKDVVNDSCINDTEVHRPGGYHRHRNPTTRSSVASILATHHTPCESLHSVSSDFDWVMDDYAAQQRLQSYADDEGSLTVPLPLDTTVTESPPELTALETRESSFRRGCALGSQTPAAPPLTCATVVAEDLRQNDPTLQVRSAASSTSHFALLLCTSSNLQPPCQNSQHSPHTSVLGSLVTNSNGSLCMDSFASLEHTPAGRSITNEAAMENSATGCDAPAMSTFFAGDHVADATPAAVAVRGVAEERDERVAGDVLATETPVMEVDAKLKSHARTRLAMNNSEPVLRSSVKQSSSPGSRNTDLSSRVTHSAVHTPGDVCVGVADTTPSISSATRNELAAGSQSSLLDSRLHSNSVFKTAWRRHTQHEANTAVSRGVWEVHTRPSTALSANAVADSRDGDDVENRFDDVPTLRDRYTPCPTPVLGIDGCDTHLIVPSESTPPPPPGVLRKPGEQLHQPREASLCLSSAHLIDTEDNATALKSMAIAQEIEGQQTEVVEASRRRVAPELSSSPFSINAASSTTAASLPQRGRHPGERQEDKREPDDLLETDHRQCLQQREQHQQVRNDYDDGAQSQTLCGAHGSDFLVSRSYPGWSSVSTQPYDTEGSHSRGDMQDELPGEPIMIMNAGGGGSESCGDCVVSAPSSPQSREGSMRDKAVVDSAAAESREGELATPAHLFTKAMATTRTTVTTTPEYHPSASGQRTHLSVPAAFSKPPMGSGVYRPLLGNVLRCSSAYAFRGGDSVVPSEEAGSHPRRQWAMAAAADKDAHVAEADGFGAEVDDDEDGGYCTYGYESDLIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXT0</accession>
    <name>A0A088RXT0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_320860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO00973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701773.1">
        <property type="nucleotide sequence ID" value="XM_010703471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXT0"/>
    <dbReference type="GeneID" id="22577827"/>
    <dbReference type="KEGG" id="lpan:LPMP_320860"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320013600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_320860"/>
    <dbReference type="eggNOG" id="ENOG502SIMR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273330at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839116" evidence="2">
        <location>
            <begin position="19"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="695"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1142" mass="126453" checksum="46EAF16930C23860" modified="2014-11-26" version="1">MRLGAHGWCLVCVYSGAAMRWLSTHTSHQVAALSYLLRDPREFPVVIVAGRSFSACTTLYRTLPTATYTAYNSETALDRGTAERSATYPDLPHSSSVRLVPHTSAFLGPELCEERDAYLDIMQGAAEPVGAVDTDPLLDADDGDAAALDKSGRIARDTRDEEEMRRSIASSFTEHFLSSIDDTWHPQSTYRSGGETAPMQASGELYARLVPHGGFHGIDSDFLVSRHDVKRGALVPRVHWVVSRWLTDYKVDVRKAIDAWSSVLSHSRPGEVASLVLFVNVEVVDIDALIGIGGGHRLQTGLNLKCCATVNTRLRLASPPPCGCAACSAVWWPLSARSSLWVSLHPLHAQATIFAEASFACASSAEATGATALARREGMQIGAAAGLPRRRRHVEVAIVNCWDTANREAEGGHATHFIALTASAFRHLFSVVPTDLQTHDHRPRPGHGHLQRIPDPLPKWQWVLHKDSSPCAVPPSGAMLSRALPYLVVSDAEEQQREHQRAMRRNAVDAATLQSLNSGVLSAGLSTAVCDPTSAPLPSPRYFTTLISDVGSLLACDGCLSDLFVLEFQPALLEAEEGLHYQRLMRTKIPRSDTGSTLRRYHARLELLSAAEKYVASALPSTSLTRDFLNRAMGFLYNCGRGRGVLAWPLIDPAEGRRCLRLGFTLSYEFHTNPLFFFQHLRGAARAGRAGEARMYRPSSGDDLVSSPSAAGPGESQPPLAIETVKEVICYILMNMRRLGWVLVWQEDHHRWPTAVPPPHMHPNTNTLPFDVSLRRYPDLGLQARIAASLEKWRQEQLRHSSKRYDVDVSAKALKAPASHQMVEPARMAAEGAVTASPYTSLDVWQAALIPEDAGVYLWEGQTVFLDDGRPGVIVEFRPPPEELFTPVEHHPTEAKRTYWREQQLLHADFIRFYRWRCHCCAAAHPRHITAAFTSLPHYVRAREMARFPVVKLLHASATGKRLLVQVLPRRTMWYHIAYPRVRVVSAAEQKRWHEAHGQTVFAESELQDEVRLLSATGVDGRSASSVMLLRLPLSPFRIEVAASLFVSRVMELSKLPGGYEAQHALWHATSPNTRRAVLQRLHTKWAIHHGNTIEKYGSAAQRLRAAQRLGHISWRSFAAQHHSTAALCFAGSTARHDAALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RY88</accession>
    <name>A0A088RY88_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">lysine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_300140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.1.1.6" evidence="1"/>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701050.1">
        <property type="nucleotide sequence ID" value="XM_010702748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RY88"/>
    <dbReference type="GeneID" id="22577068"/>
    <dbReference type="KEGG" id="lpan:LPMP_300140"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300006500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_300140"/>
    <dbReference type="eggNOG" id="KOG1885">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21243at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000163">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001756">
        <property type="entry name" value="PRK00484.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918:SF1">
        <property type="entry name" value="LYSINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918">
        <property type="entry name" value="LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="6">
        <location>
            <begin position="112"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO00250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="536" mass="60553" checksum="E8EF84D6C602BE95" modified="2014-11-26" version="1">MGRILFITIRSGEAQLQVLRQVSESFTKTDLRAFADALHTGDILGATGVPGRTAKGELSLYATEASILAPYVCTDQALCPDLRGFVPLTDTDIKYRYRFVDMMSNPSVLQHFRKRHAITRALRDYLDARSFIEVETPVLHSVASGASARPFITHHNANGADLFLRVAPELHLKQCVVGGMERVYEIGRVFRNEDADRSHNPEFTTCEFYAAYHTYEDLMVMTEEIMRHLALAANGTTKVVVTSCVAKEPVEIDFEQPFRRVSAYDAVQEAAGVELPPPTELNTPRGLAYMSAIMLRYNIPLPSVRTAAKMFDKLIDYFITDRVVEPTFVTGHPLFMSPLAMEQRARPGLSARFELFINGIEYCNAYSELNDPQEQYYRFQQQLLDRQTGDDEAMALDETFLKALQAGLPPTAGWGMGIDRIVTLLNGSATIRDGILFPLLRHDATSHDARRRCKTASFFGFNRNMTLFCLNALEEEMLKRAAPTESLEKIRQLRRYLSTMPHRDMMTYAPEGSASRGWRYEATMAMLRFFCCGGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYT7</accession>
    <name>A0A088RYT7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_322170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701901.1">
        <property type="nucleotide sequence ID" value="XM_010703599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYT7"/>
    <dbReference type="GeneID" id="22577958"/>
    <dbReference type="KEGG" id="lpan:LPMP_322170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320027300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_322170"/>
    <dbReference type="eggNOG" id="ENOG502SRFR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271360at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="91" mass="10253" checksum="F21E20928D6DCCED" modified="2014-11-26" version="1">MRLTAGKIYFWGAVAIVFLTAWNRHSTAHLRTVVDGLREERLREAERLRQHQRGGEGGAGGDSVPTSVSTMPKYFNPYYKQQEIENASTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZ21</accession>
    <name>A0A088RZ21_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cyclin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_323500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702034.1">
        <property type="nucleotide sequence ID" value="XM_010703732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZ21"/>
    <dbReference type="GeneID" id="22578091"/>
    <dbReference type="KEGG" id="lpan:LPMP_323500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320041600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_323500"/>
    <dbReference type="eggNOG" id="KOG0653">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044772">
        <property type="term" value="P:mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20507">
        <property type="entry name" value="CYCLIN_CCNB1-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046965">
        <property type="entry name" value="Cyclin_A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001771">
        <property type="entry name" value="Cyclin_A_B_D_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="54"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="6">
        <location>
            <begin position="155"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="171"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO01234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="303" mass="35131" checksum="B4880816D7F06608" modified="2014-11-26" version="1">MFVERERQAVARFNEGNTSSGPTNTGTLYAYYASPEYLQYQPEINEKMRMILVDWLIDVHLKFKLHAETMYLAVNLIDRYLSCANNKADRTTFVPRAQLQLVGVSAMLLASKYEEIWPPEVKECVHISANTYTREEIIQMERSMCTALSFRLTVPTPYPFASRAWTVLEGDDFLGVGTDEEQRRQHFAIVRHATSFFMEHALLDYKCLQFTPSQIAHASVFLALLVLRTKLELPKASNFPVWTDALRYYTKAEVHEFRGCAEVILEYVNYVPTTKYQAVRRKYNSGRYMEISKMLLPNELPTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZZ0</accession>
    <name>A0A088RZZ0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Squalene synthase</fullName>
            <shortName evidence="11">SQS</shortName>
            <shortName evidence="11">SS</shortName>
            <ecNumber evidence="4 11">2.5.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_312810</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2 (2E,6E)-farnesyl diphosphate + NADH + H(+) = squalene + 2 diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:32299"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2 (2E,6E)-farnesyl diphosphate + NADPH + H(+) = squalene + 2 diphosphate + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:32295"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the phytoene/squalene synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.21" evidence="4 11"/>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701665.1">
        <property type="nucleotide sequence ID" value="XM_010703363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZZ0"/>
    <dbReference type="SMR" id="A0A088RZZ0"/>
    <dbReference type="GeneID" id="22577707"/>
    <dbReference type="KEGG" id="lpan:LPMP_312810"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310035900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_312810"/>
    <dbReference type="eggNOG" id="KOG1459">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="431150at2759"/>
    <dbReference type="UniPathway" id="UPA00767">
        <property type="reaction ID" value="UER00751"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055056">
        <property type="term" value="F:D-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051996">
        <property type="term" value="F:squalene synthase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045338">
        <property type="term" value="P:farnesyl diphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000003">
        <property type="entry name" value="Farnesyl-diphosphate farnesyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006449">
        <property type="entry name" value="Squal_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044844">
        <property type="entry name" value="Trans_IPPS_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01559">
        <property type="entry name" value="squal_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626">
        <property type="entry name" value="FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626:SF2">
        <property type="entry name" value="SQUALENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01044">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01045">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIO00865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="414" mass="47254" checksum="0B9ECFFBBCCB5801" modified="2014-11-26" version="1">MGLLSDSLAMMRVKWQMRSVKLQVPPEEADLRFCYEVMDDVSRSFAAVVAQLADQQLRDAICIFYLVLRALDTLEDDMSVPVNVKLKEMPKFHTRMSDTNWSMTGVGEGRERELLEKYPCVAREFKKLRKEYRDVIANICERVANGMCEFLQRPVVTLDDYNLYCHYVAGLVGHGLTHLFARCGFEDSHLDEDLTNSNHMGLFLQKTNIIRDYYEDICDEPPRMFWPKDIWNLYATELKDLKRESNSAAAVQCLNAMVADALVHVPYVVDYLSTLQDPSVFRFCAIPQVMAIATLKEVYNNPDTFHVKVKVSRPESCRIMLKTTTLYSSLSLFRDYCVELQEALDRDDPSSTSIANSLAAAIERIDMELKKCQDVSYTRSLLARYPGLGGQFVLTVMDTVSGFFGGRREIVGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S019</accession>
    <name>A0A088S019_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA repair protein RAD51 homolog 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_332600</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702351.1">
        <property type="nucleotide sequence ID" value="XM_010704049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S019"/>
    <dbReference type="GeneID" id="22578413"/>
    <dbReference type="KEGG" id="lpan:LPMP_332600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330033900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_332600"/>
    <dbReference type="eggNOG" id="KOG1434">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5957327at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033063">
        <property type="term" value="C:Rad51B-Rad51C-Rad51D-XRCC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033065">
        <property type="term" value="C:Rad51C-XRCC3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000707">
        <property type="term" value="P:meiotic DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052093">
        <property type="entry name" value="HR_Repair_Mediator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3 RAD51C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="9">
        <location>
            <begin position="218"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="62"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="143"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="316"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="147"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="410"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIO01551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="684" mass="73040" checksum="F7C88D1EBF197CDF" modified="2014-11-26" version="1">MALIECSESLSSATKAKLRDAGILYVSDVVALLSSKCYRAGDDSEDQVLSVLRHPSALLRHQVSRSDSCPPRRLKPDTPGESGGAFDDQSEPAHVSALRETAMRSTLRKVAGASRFLNLTEDEVNEIVEMAIHATVMADEASKKHSVTASSAQGRHSSYGALSSSPPRPPESPSRFTNSAHNTRENAHATDSHTGAIPGCRTLRELYAEVEARQARGLPTHVTTFSRQLDGILGGGIPVDGVTEISGPPGVGKTQLLMQLAVSCAMPVEFGGMGGACLFVDTEGSFVVERLEQMATAAVSLVRTILFSRSSLPRSETAAAPPAATRQPPGSHRKRCRSPPLEPHTVPYSHGSCPNMGGIPGIQEEFTVESVLQRVHYVRVTDLAGLLALLYSLPSWLEEERSDEAKAVDTGSTAATSTCSSRQDKSADSGVRATVRMVLIDSIALPFRSSDDFHRGNFGRSTSGGGDSAMDLLSCTGRGAAPNSLLLQSPYGLLSKHGLWQRSRLLFQCSTLLEHVAATFQLAIVVTNHMTTKTLRDVALNHTTNGSATEGSACSAAAAEGNAGQLRQSVLVPALGDMWSHGLSTRLLLSFHHYDIPVCSFVDLPTSPTTATVCTEDVVYSLTARQQASLRSVAQHRVVRVLKCSGQPRREACFLITSKGIRDACKDMVSQRFANSVGSSESHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S024</accession>
    <name>A0A088S024_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">carboxypeptidase Taq</fullName>
            <ecNumber evidence="8">3.4.17.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_332650</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Release of a C-terminal amino acid with broad specificity, except for -Pro.</text>
            <dbReference type="EC" id="3.4.17.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the peptidase M32 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.17.19" evidence="8"/>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702356.1">
        <property type="nucleotide sequence ID" value="XM_010704054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S024"/>
    <dbReference type="MEROPS" id="M32.003"/>
    <dbReference type="GeneID" id="22578418"/>
    <dbReference type="KEGG" id="lpan:LPMP_332650"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330034400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_332650"/>
    <dbReference type="eggNOG" id="ENOG502QQRM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275647at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06460">
        <property type="entry name" value="M32_Taq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1370.30:FF:000003">
        <property type="entry name" value="Thermostable carboxypeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001333">
        <property type="entry name" value="Peptidase_M32_Taq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34217:SF1">
        <property type="entry name" value="CARBOXYPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34217">
        <property type="entry name" value="METAL-DEPENDENT CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02074">
        <property type="entry name" value="Peptidase_M32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006615">
        <property type="entry name" value="Zn_crbxpep_Taq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00998">
        <property type="entry name" value="CRBOXYPTASET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52034">
        <property type="entry name" value="PEPTIDASE_M32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 10" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00066553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIO01556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="498" mass="57267" checksum="CB7613186057BBE5" modified="2014-11-26" version="1">MEAYKKLETIFTKIYRLDHFLSLGHWDMNTNMPPKGEDARGEAMAVLGELRFSFITAPEVKDLIENATKGSGELNTVQCANLREMTRAWKSATALSTEFVGRKMRLTTRAHSVWRDSRTTNDFKKFLPVLKDLVELAREEGSYLAAGTSLSPYEALMNQYEPDITTQKLDEVYASVKSWLPQLLKDILQKQSGDSVIEYSQKFPQNKQEALCREFMKTWRFDMDAGRLDVSPHPCTEMTKEDCRITTNYIEETFVQSLYGVIHEVGHGKYEQNCGPRELITQPVCNARSLGIHESQSLFAEFQIGHATAFIDYLTTRLPEFFEAQPAFSQENMRKVLQRVQPGYIRIDADEVCYLLHVILRYEIERDLMMGKMEADDVPRVWNEKMQAYLGLSTTGRDDVGCLQDVHWSMGSFGYFPTYSLGAMYAAQIMASIRKEIGDDKVDQCLRTGELDSILEKQREKIWDHGCVYNTDDLVLRATGEVLNPEHLRRHLEARYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0J4</accession>
    <name>A0A088S0J4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_321750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701860.1">
        <property type="nucleotide sequence ID" value="XM_010703558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0J4"/>
    <dbReference type="GeneID" id="22577916"/>
    <dbReference type="KEGG" id="lpan:LPMP_321750"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320023100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_321750"/>
    <dbReference type="eggNOG" id="ENOG502S6BH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266492at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37028:SF4">
        <property type="entry name" value="ALMS MOTIF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37028">
        <property type="entry name" value="UNNAMED PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="326"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="421"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="510"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="620"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="741"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1052"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1144"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="421"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="437"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="647"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="741"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1067"/>
            <end position="1081"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1204" mass="131119" checksum="6CE839FEEBFAA035" modified="2014-11-26" version="1">MRPQYTENHSALQLLPQTRASQMEVNAPNEVESASSSETTLVVTTSGPSSQRSFSKSALAAPTASPMQQREANSLLNATTEKIAAQLVTQPTDGFALHHHSRCSSDAESLDYVDELASSAFQDCRSAAQLLTAYSQSQLTSYMDAMPFTVGAASSEPPRTAQMSALHCLAGDDSEDSNEGHGSEDHAGRRIEKTGVSDDAADDAFAAQNTTIEVLLPVDDDDAAAVQHEGHEDARGVGCTCHGAEDITKDASSDTPESLLKVFYGKERWAGKQPAISRGDLSTRDAKLALTPAAAPSSAAPRHTDSADWVATRKTALDQLRTKFNERSTAVASRAPVNRVSSPFAQREGENAHRVQSTSNSVAHRGHALQPSDSFEDLSKVPLAGETSVSSRKRSPPRAEATTAASILDKLMGDSWVSSTTAIPQTAQPQRTPATHSDLDEGESHTSLGERSRTLVKPTGDLAGARAMTTGESGGRFIVRPALSTDVSSISPIKNEASSILADLYSTLDTRPPATAAPQPHPGSLATTTPPPRAQQRRGGPSAMEKVHEASVDAVTADFCTAQTAPSSASASWTDSPVWGRVAANATVTTAATANEIEHLPPCPRASRLNHAPPLDRGRVHSGIVLNSNDGDTAGSGLRPDAEVSVVPQSAPNSWDTSRVSKWRSSDHEELSRLEQSVVDTYATTPSQENTALTRAAEWRQQRVKEEMRAKEMAECTFHPLLSPGTRVMVRLAQERELERTLQQEEKDAGAESAGTHTKSARINCPQPSLDSSTLKATLQTVYERLYPAELSATASRRQIIDQEMEYRRLAREELILLRRRCGVARCASRNARNNGVPWTRDTFSSFMSTILEVDWEEAATASSVPLSAAAASCHAESRTTGSAAAPVAVVQTSYKSPMAVALLEELNAKRKYNSRRKAEMQGRHAKGSGAEVVVGRGHRHGTAQSPADGTEAAPNEESFRVALFDEFLLRQNAYYFNRSRTVRELEKKMTPAFTPSTTEASTRLVQDMVSRSLLNESMGPETSSIVARRERQRIPFTSSFVKQHTSPYVDPCTFQPSISPAARASKNMERRHPSGKRETMAEQQQSFFERLYTEQQRRAQRRENAKKRAEAAEVEGLTFQPTLNVKCNTHVRSLLNPRNYQPYQAYLQEKRQLLEAKRKGQEEDARQAEEDVCSFRPQTTKKPAYIGKMAKSFGVLRQQDTEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0L6</accession>
    <name>A0A088S0L6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">rRNA processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_341670</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702594.1">
        <property type="nucleotide sequence ID" value="XM_010704292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0L6"/>
    <dbReference type="GeneID" id="22578672"/>
    <dbReference type="KEGG" id="lpan:LPMP_341670"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340022600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_341670"/>
    <dbReference type="eggNOG" id="KOG3080">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="443772at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008610">
        <property type="entry name" value="Ebp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028">
        <property type="entry name" value="RRNA PROCESSING PROTEIN EBNA1-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028:SF0">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EBP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05890">
        <property type="entry name" value="Ebp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="176"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO01794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="31228" checksum="2FB4CE0559B7CEAD" modified="2014-11-26" version="1">MPVYDIASRKRKNLLRRRAEEAAPHSEDKDHSQGEDEEEEEGFEDEEYLDSDEEVEEVGEALPKASGASKRGASDAASKSAAATACATRVEFSEPAQWVERMALTSTRSLPSDLNADDDPKREEAFIQQTLLSVVRGISLLEEAGVPWKRPDDYYAEMYKSDVHMNDVRQAMEASKARIEAQAHRRTMKEQKKYGKEVQAEVMRQRAKYKRDMQESLSDWRKKRRGNGSLQDMLSDDEGDRDAKRFKAQRTPRARNLRPGGNKRPGKNARRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0Z3</accession>
    <name>A0A088S0Z3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Small nuclear RNA-activating protein (SNAP), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_344520</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNAPC3/SRD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702873.1">
        <property type="nucleotide sequence ID" value="XM_010704571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0Z3"/>
    <dbReference type="GeneID" id="22578957"/>
    <dbReference type="KEGG" id="lpan:LPMP_344520"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340053200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_344520"/>
    <dbReference type="eggNOG" id="KOG2664">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003681">
        <property type="term" value="F:bent DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001046">
        <property type="term" value="F:core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022042">
        <property type="entry name" value="snRNA-activating_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13421">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13421:SF16">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12251">
        <property type="entry name" value="SNAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO02073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="430" mass="48100" checksum="5B54AD1F826000E2" modified="2014-11-26" version="1">MTLRRIADEVANIPIAELRTVNEEPLASMPADAILEPGTKVRLPVVLDYPGSPYGMVLHLGSAEAQLQDCEVLLDSLVSSWEGEYGSHSLECLPPRKVCSQTEAVLAKVHEEAIRQLPKVEAGLQQLGNREAKLPLLVEVEAIKAAERSIEESFQQSVAGLESFKKESKACGKVGLAPLSSNDLTPASLHTKRDESEDYCVMHTHRWEFAVHGVRSKEPREVWAVLSCQPLVALLDAIDCPTTRDPLTTSRNAFLFIRGVFYIDDRHRSHGDFADLSEVIRRNDPLQDASSFHALEHQGFARCPVRSAAETAFKDLNVKMGESCLLRHCGGCDHYFFLSHVRSLTGYPRTERHEFPHRVAKARDQARRCLLCRLFPATVVLYEDPLSPESPAFYCAVCFDLLHSGDTPEEAAQYQRREAKDFGEIYFKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S283</accession>
    <name>A0A088S283_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein-tyrosine phosphatase 1-like protein</fullName>
            <ecNumber evidence="4">3.1.3.48</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_352270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.48" evidence="4"/>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703164.1">
        <property type="nucleotide sequence ID" value="XM_010704862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S283"/>
    <dbReference type="GeneID" id="22579256"/>
    <dbReference type="KEGG" id="lpan:LPMP_352270"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350028800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_352270"/>
    <dbReference type="eggNOG" id="KOG0791">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF449">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="104"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="412"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO02364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="518" mass="57071" checksum="0CF8509EE8A9FCD8" modified="2014-11-26" version="1">MSNNDSCVIQPILLSESPSSSGSELPNLSSLTAAATVALTQPSLKMQSGDVDVSGSANLSYNNNDLGSSTSTAEPLTNASCSQKERNPKFNMYKLSIEEQFDLIEEEFAAIEARTMNPRMYNFTTSNANPAKNRYINVLANEETIFPPACSESVPPTTGNPRLPTSGCPPSMSLASSSIKSLTSTAQNVWKAAEKRLLSTLRSGALAKEIEGNEEPTTGCATKRRPQCYINANVVDMRVEPVFVASQAPVQECIDDFLSVIYSCEVTLVLMLTEVEETGFVKADRYWPADSAPVGRIESFGNMCVYKDQEDPYTYDATHELVRRPFYIRPSATSTARAHKIVMYQYVGWPDRGVPDSTDSFEELLKIIQQYVVAPSAPRESVAGLENAPRNPITTSNANSTRSDTRAGKLTPPVFVHCSAGIGRTGTLIGAYTAIKLMEAGLLANTSIRRIVADMRKARFGMVQRVEQYMFLYMIVLQHLGIDVRKFSACMQPRADMYNMRWMEAKQKALLEARLAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2B5</accession>
    <name>A0A088S2B5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_060520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703933.1">
        <property type="nucleotide sequence ID" value="XM_010705631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2B5"/>
    <dbReference type="GeneID" id="22572258"/>
    <dbReference type="KEGG" id="lpan:LPMP_060520"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060010900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_060520"/>
    <dbReference type="eggNOG" id="ENOG502RZUG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271732at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN95611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="311" mass="33351" checksum="D99E3303DDC0AB09" modified="2014-11-26" version="1">MSSNAFSSGSAPNVSSAAVGTTAQQADTLTRNFILGIPRGGLLPNSPEAADLQAAEAFVSDIQQEILAYDIANARAIESYAVRCWSAVPFFGRHAKRALEAEATATAAAAAAAEETHKSTDTAGVAAAVDGKVSSSGGHGLHLSPEEAAAALQVGGVYLHRQTSQTPRGFKVERTSAIELKQLSQFTDGARDASGSKAASKSAVAVAASKTAPAPEVNTWLFRRQHPSWVPLMQRWWVPWLCCGSIVLIWTPDVWKLRTLYFCDHQYALFRQSIHKAYWWATMSPEDYAAHMADITAERPSRVSGASCPFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2K7</accession>
    <name>A0A088S2K7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_341680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702595.1">
        <property type="nucleotide sequence ID" value="XM_010704293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2K7"/>
    <dbReference type="GeneID" id="22578673"/>
    <dbReference type="KEGG" id="lpan:LPMP_341680"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340022700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_341680"/>
    <dbReference type="eggNOG" id="ENOG502RBKW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268690at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102405">
        <property type="entry name" value="MCP/YpsA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO01795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="739" mass="82458" checksum="F845A8B0BA3A5C96" modified="2014-11-26" version="1">MPSESCRWYPDTVTHHKQGDSYTVSRGRNHNPFDLATCDARIIEYARTNRHEAKASAVINELHPQFRGLVRGVTCEFLLRSSITQLGVNAVNIEIDIDPKQRRAIITMDLVALAPLAVLMLDYIAVGAHVGKLFALESNRVVRNMDYITRLLNAVNQRGQPLLVYGTDEAPNWDLKIVDGRAVAYLPVLPGTFTYSGEIHGLLPTIGMALRKGTAYKDLIRLHQQFHEGYTRVAASLGVLMVRGHAMHFRTVFGRVVDNLLPKGLHSMSSRLIEPEEGLADAHSRERVFVFYGDSVDELTHVPIEFYTLESYREQVPFSLRKTLADRCSTTSSILRAFKSAPKGDLPCCAYVCKGGQFTEMREDDWIVADPKQTTYVGIENPVEQQELVQRYTYQQCEYAILSAIAIDDITSDGVLFTRYFPSPCLKSLILSRAVCKKLRAIFFTRASRHYGSFFSQEDAAMLGDLNTFGIGVFEVNEQKGEVYQYIRRPGRDSGAFVPLERRQEYLSATFFGVYGSNLIAGDFEAELMTLLSGILHIRKTCQHPLLNEKKPLALVTGGGPGAMEVGNRVAKSLGILSCGLIVDFGSVAAKPGATINEQNQNPYVEAHFTYRADKLVERQSDFNLDFPIFLTGGIGTDFEYALEEVRRKVATVPPYPVILFGTTEHWGTKISGRFQANLQSGTIRGSEWICTVPWVVSTGAEALEVYRHFFEGNLPVGPNQPTNDRGFMVAAEYLAKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2T8</accession>
    <name>A0A088S2T8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Generative cell specific-1/HAP2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_353960</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAP2/GCS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703331.1">
        <property type="nucleotide sequence ID" value="XM_010705029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2T8"/>
    <dbReference type="GeneID" id="22579424"/>
    <dbReference type="KEGG" id="lpan:LPMP_353960"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350047600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_353960"/>
    <dbReference type="eggNOG" id="ENOG502SHW5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272303at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007338">
        <property type="term" value="P:single fertilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040326">
        <property type="entry name" value="HAP2/GCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018928">
        <property type="entry name" value="HAP2/GCS1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31764:SF0">
        <property type="entry name" value="GENERATIVE CELL SPECIFIC-1_HAP2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31764">
        <property type="entry name" value="PROTEIN HAPLESS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10699">
        <property type="entry name" value="HAP2-GCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0278">Fertilization</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="534"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Generative cell specific-1/HAP2" evidence="12">
        <location>
            <begin position="25"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIO02531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="570" mass="61095" checksum="8CD841E8D9FFC8E6" modified="2014-11-26" version="1">MSGTATATAYVRHCDATSSATPPGCVRKLVVDLTLDDSTLAGAILETEVTVEHALHQSLFPHDAASDVAGAAATSLQVSLPPIRVALRRSAVQVRYMLTYLRTFPAALRDYVKVLHTAMSCDDGVTRCPSYTSMTGGLVSAPLGVCCLCIGIECALTNEFCNVSMRGHFCFRTGAAGSICVQNEGIVYHGWSVGSPLPYYTLRLSASGQGIAQTTLQLTTDAPSAQAGASFLHLVQTSGVSPGEGGTTVDIAGRVLFVPSAESSSGSTSHVRDDDPAEWLLLPASLVSNSGNECDKVGISPDYFYSQSSTTQCNAQKGTCVRHQLADYREEDLAQIAQGKGGRYIAAFLSIFTRQRVGQQEFLLEAAQRIGGAVLRWTVNADQLVFKLFPVSGVLDTVRFVSGTGALYVTVRNNNTYGGLYYVAVAQCQRARVSDCANDGVTSECVREALVAGANTSSMFQFSMMSDPAEETGSTASCTVVLRDAANALLASTNVSWAIEATTPAPNLPKAEQCRRCVFSDLRCFFSTVCEWQMLVWTAVAVTVTWAPYAILAYWRMVWHFGSKYVAWLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2Y9</accession>
    <name>A0A088S2Y9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2 domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_354440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703376.1">
        <property type="nucleotide sequence ID" value="XM_010705074.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22579472"/>
    <dbReference type="KEGG" id="lpan:LPMP_354440"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350052600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_354440"/>
    <dbReference type="eggNOG" id="ENOG502QRAD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="262033at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39670:SF4">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39670">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="243"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="819"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="977"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1563"/>
            <end position="1632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="987"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1598"/>
            <end position="1616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO02576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1632" mass="178625" checksum="77EB2DC8AB94CE70" modified="2014-11-26" version="1">MPSPHRSTSSPSRRTRTATTDQSSGFPIHPTRHSRHSRASTRRSYQESSTSYYDVDEARKEVADCATPANQVSPDTPHLSPYRQYETNSTGRGEQDRSDDAPQDYPRLAYHRNGSVSQMNQSILKLAGGRRRRTRRFGTVPIHPSSRYVSVTNRDVSTPHSRKPSKSSAGRHATDVHPSRASRMVEFSVDIETLEDYKTPIRRRQGGVGYVYDHGVGHTAAPLAGRVGRHDREDLPTVVYAHSNGNVDESKANSTAAAAPAEPYHFRVRLCECQGVFADLEALSRTPPAVYFAVHTVKERGHSGVVEKGSYNPVFCDEFMFSSADPEQDALVCTLVSVSSVNDSRGGSMQREKKVAECVLALHNLAWQVERKVWVPLVRHPGTSQAYEQGEVLVSIYSADFGYDDVATEAEEAACSTAIHDILTHYAPQELHRLDWMTGAYVNKGPEALSQLRASYRARTIEPVPVRVTVQRIDGLTDEAGCPTRASDIYVVVGDGCVEQLSKTVLYRRGAIINQEFDLVLLNPAADTVSVTVFGNSRKLGEAVAGLTNIQAGKAKEVKLMLVRSAETGDASNGGQATITLQTEKYSSPRQMTAMQETRLRNRVLAYLWRYLRDDLHRLDAIVGRIDNEEVYMQEWARAVGPEQKPTRLTVRVREARNMFSDGGLLPRCYARISAGPATVRTGLATVRKGLVTFSDTFSVQVYDPAHDAVEVMIVADGDDGECEVSRVCFGVANLPRQRCVVRTLHLVAAATKRVAHVQGELTVELVAEDFGLTGALAVASEASIGSSSSLHMQRLEVIIQQGTPEKLHRVPYMLDTAPPGECERFIEDQEKQYGAHVAVAPMTVKILGVKAFKPVGNFYVKVYLNKEPILRTEDVKGSTEVVMNIEDNNETTVRLKEASQTVLFFKIGQHRALRKTAVLGETEVALANLVRGEKNVLWLPFFHPSTESASGYGGGTHLGSISCVSVRQNNAVKLKGNRMPDSNGIGTTQQQQSSGAALAHHGAATPSPEGLLGMELQSLAFPATTVTEYKLDDESGRRGVSVQEAVTYDMTSLIAKMRPSELTKVQPRIAQCASLKSAHDELRAELSRTPIAATIYVNIESVELATEAGKAQEAQGRIAVEAVYGSERQRSCKRTEFANDALHQRQCYTQIRLDIPEKLNSTTNGHNGATSRAAGDAKGVPPLELRLVGVHSSDWAVGAVLGKTGSVGSGGAFDEGGRGMNHYDATDSASDTTADSCYVGGENNIHSYIKRPKYRSGTWAIKRQKEGRVGCLPNTPILPRQHSSRTGVPTVSSYSNHCQSYAEVQHSNYCDVDEEFYLSDAKTIRSYVDSPWQSRQQSAHCVEWTLPRHHSGQANLKSITNYPSSMSLSATTASVPYNSCAPCRGEIGAVCLSLRALLTKPLYKIGETLRVPIVLPSMATKLSHRGPCSPEVNRRCVVGHVTLRLTLPAFESIPESLRLGSHHVMSKVMPSYVHYYERRIGAYMRSHNAAGLVSLHYNLYERDVASGCWPVSLHGWMQALIKRFGPETDSFGPEPPLPFDPEEWKRARQCSEVLRREREEALTLSEKGSEGATLHTDKHSGAHCSHSVGSSAYLGGNSPNRVTAAGTTKRSSSANGRPDAATAPAGAEHSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S343</accession>
    <name>A0A088S343_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">U5 snRNA-associated splicing factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_343830</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702805.1">
        <property type="nucleotide sequence ID" value="XM_010704503.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22578888"/>
    <dbReference type="KEGG" id="lpan:LPMP_343830"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340045600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_343830"/>
    <dbReference type="eggNOG" id="KOG1795">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1931567at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000002">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.40:FF:000002">
        <property type="entry name" value="U5 snRNA-associated splicing factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.230:FF:000002">
        <property type="entry name" value="U5 snRNA-associated splicing factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.40:FF:000002">
        <property type="entry name" value="U5 snRNA-associated splicing factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.40">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012591">
        <property type="entry name" value="PRO8NT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012592">
        <property type="entry name" value="PROCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012984">
        <property type="entry name" value="PROCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027652">
        <property type="entry name" value="PRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021983">
        <property type="entry name" value="PRP8_domainIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043173">
        <property type="entry name" value="Prp8_domainIV_fingers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043172">
        <property type="entry name" value="Prp8_domainIV_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019581">
        <property type="entry name" value="Prp8_U5-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042516">
        <property type="entry name" value="Prp8_U5-snRNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019580">
        <property type="entry name" value="Prp8_U6-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019582">
        <property type="entry name" value="RRM_spliceosomal_PrP8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140:SF0">
        <property type="entry name" value="PRE-MRNA-PROCESSING-SPLICING FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08082">
        <property type="entry name" value="PRO8NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08083">
        <property type="entry name" value="PROCN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08084">
        <property type="entry name" value="PROCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12134">
        <property type="entry name" value="PRP8_domainIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10598">
        <property type="entry name" value="RRM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10597">
        <property type="entry name" value="U5_2-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10596">
        <property type="entry name" value="U6-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="JAB1/MPN/MOV34 metalloenzyme" evidence="8">
        <location>
            <begin position="2186"/>
            <end position="2318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIO02005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2425" mass="277726" checksum="080378985F683714" modified="2014-11-26" version="1">MSAAAPPGFAEAVSGPPGFEDEDDFADVNSALLAEMEKEEQKESRKRQILTWQRMNTERYGFRSAYRAAVGEKDLMPPEFIRKVVKDNGDLGGKRFKSERKLCVGMLPYMPLALFKLLENMPMPWEEARYVTVVYHVGGVLTIVDDTPTVAEPLYLSRWGSMWTKMRANKVELLQEGGGFRRAVHKGDENEPPLDFADYLMDRVPPPPVRDDLDEEDNAGIAGWFYDPFPRLVAPNQIRGPRRPNGYYFTIDVIEALYRNASPILPTLDDRSYFYLWDLKSFYSAKAMHLSIPRGPKFEAPPAIRVKQDEDDDWTEFNDLRRIIHRDNPRKPRFTMLTERQIAFPFLYGSVVDGVELGPYHYPATVRVENDDPELPCFTFHPSLNAIKAVERNYTDVPRAQAVLCSSTWDRAGVQHAEGAVDVPLELPDDFEPFLAALPLEQPNTKTGLSLLFAPAPYNSFEGGMKRRIDVPLCDKWYQDPPDLLTTDDRDKILRSYTQLLKHHVKRSLQHTVRQRGSAAAASAAAADMSAIQEKHRLQKMAEMRYFSKTRMEWLEAALQVMRQGHNMLAQLINMKCLPYVHIDYNFEAKPTRTLTTKEIKKSRLGPAFHMIRELLGFMKRLIDMHVMYRLGSTDALQLADATQYLFSHVGVLTGVYRYKLRALRQIKRSRDLKHMLYSKFNVGGVPSGPGNGFWGPAWRVWVFFMRGMTPLLQRYLSNLTDRVLHGRVQKGKTTGKKITRQRVEPDKDVNIKEAFRRELREMLPDSVKGSVIVTMDQHMNEAFRHWRAGIPWSVPGLARPLADLVGKYVKLRSEEYIRTTQLQRRRIAEGDTVDKQAFMKNLGRLTRLKLMDEQRRQRRYMTGEDAATILSPDEATEIYRMMANWLNDRGFKKIPFPDPSKTAELSLLQLSLNRLRDQHNIANRLTANQREEQARIEESFNAPHEALSRIVDALAHQRRFKNVEVEYMDNFSHLYPLYTVVPQEKMIDSFLDQYLWYKTMNVQRLFPNWVKPSDVEPLPQLLYKWCEGINNIPDLWDVSHDESVVLLHSNLEDAFYDNVDWTFFRPMLELIMDKSLVDYVVSRHDVVVEFKDMSYHHYKGLIRGFMFSPFLAQYWGLVMDVLLLGTQRSKEIAGTAVKPNPFMSFFRDPYLATSHPIRAYCRYKNEVYIVIRYTKTEADEVRRRYLEETKSDPEMHAINASVYGFKNAKEWPRDARMRLFLSDVNLARAVLWEFRGRLPPSMATINDANSFVSVYSKDNPNLLFEMAGFSVRLLPVVRTEAEILENESMWSLRNNTTKDISCRAFLQVTKEHINMIRNKARRTVMMVGSSTFHSIAAKWNALITEIVPYYREAILGTEELQAILARAEHRMQARVMMALNSRAKSRFPPAMFYAPSDLGGLGMLSVGHSLIPAKDTIYSRTTSTGVQFFYAGLTNEEGIPIPNVLQYYTPWEAEIKESEKAWLEFRTREREAKARGGRVSLDDIEDIIDKGIPRIRVRFSRHAPLFHFDTGFRVRMEFQRYLAGKYLKNWWFHMEHDGNICGGVMERYRADMNNALGGVEAILEHSLFKGTGFPSWEGIEFDRSGGFENTKKDTKLAKQQRAGLSKVPNQRFALWWSPTINRSDIQAGFESKVETTGVFMCGKLETIKKSLIKIFSGSLWEKSHGAVVNDVASKLKDSLIDLGAASITLQQQHPQKSYTFTSSAADVILVSAARWSVPSKPTSLADEVGDVYQQNTTSKFWIDVQLRWGNYDSHNIAEYARKKFYEYSTARMYPFPAGIVVAIDLAYNCHSAFGYWIPGMKLFMSKLMPVIMKNNITLNTLRDRMKRDLGLFSSAPTEASLSDTNIAELFSSGMRTWIVDDSATYVTSEQPTPDGGKKFKSENGAVLVFEPVSGSLKMSVVHRSVFAGQKRRSKLAREKAAEEIASWLRSCPPSERPGKIIVTRSRFRQTLHNMLVLDYPNIIIGQSDLNLPLPMVLRHSRLVELRIAAMESKGWEFCIYDDWQQSLQFQPITCFNLLNLVLRGYHINLQRTRQILVPDLHVEVSAAHFWPTYATRQEWEQVSIRLQEMIIADAARRMNVSPKDFTEKEKEGILLGKRMTNLEIQQEEIKEIEAMRRTKLVEAQTVSVVTSSGDVVKRKVKAAFDFGATAFNNNWRPRSLADAAFLDENTTITFDAAGATGASDQLIFSEDAVQKLLACCDVKVQCCAYMFGHALPDSPNIKEVLCVMIPPQFGTAVEARTPPRIPYDAAPLREANLSFLGLMRIGESEAQLTSHDLALQARALIANEGMVPQGFLTAVLEMSEEGVIVRCYSTTADGIAWAQVEYERLLKKTPEATDPVFSSPCRGTLSSEVRSFFLVPVERVWNYYFKGALWRENTEYDVVVDLPLHFFDALHRPDHFLNFTRMGDDAEVMDEADPNDVFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S399</accession>
    <name>A0A088S399_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_355580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703489.1">
        <property type="nucleotide sequence ID" value="XM_010705187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S399"/>
    <dbReference type="GeneID" id="22579586"/>
    <dbReference type="KEGG" id="lpan:LPMP_355580"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350064500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_355580"/>
    <dbReference type="eggNOG" id="ENOG502S8IG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271467at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839213" evidence="1">
        <location>
            <begin position="31"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="433" mass="48769" checksum="D034F559901D5AE5" modified="2014-11-26" version="1">MVGPPRLPSAAARALVTFLLLLGLVHLAYGWSSSDAYTIVLLNDFDTDLVLQDQFYNAPNGTLLTIARSGYRLMERGIAPSTSASTLTATKGASALAGEAAPTPVYALDERLSTAMAYQGMKAVNSPLPFRCRLSGEWVVWSKERPRGSGVDEQPRGKDAEPEPALLHCRLPLPQNQMEQALQQRRYIAHNRAAMSAALEAWWHTAASEQASRCLYGDGEKALTGTERYYELCPAGVVYRVQHQRLKRLLQIPSQHRGTGDDFMRMEDTPSVLHFLHKMHYSPSNRDAILQNSQYNGVFEPIGRYHSRLSKPRWNMEYLVWESWYPSTNPCVTHYTLLSDFSGAGVSNENTTARTRGAPRAVRPQDAYWKTVVRFRCPSHRSEKRTHKTSLWTVTEARQLCEYHVEVMSDLVCGWEQELDSFHVNPVPCVVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3D0</accession>
    <name>A0A088S3D0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Choline/ethanolamine phosphotransferase (CEPT), putative</fullName>
            <ecNumber evidence="7">2.7.8.1</ecNumber>
            <ecNumber evidence="7">2.7.8.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_356050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.1" evidence="7"/>
    <dbReference type="EC" id="2.7.8.2" evidence="7"/>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703534.1">
        <property type="nucleotide sequence ID" value="XM_010705232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3D0"/>
    <dbReference type="GeneID" id="22579633"/>
    <dbReference type="KEGG" id="lpan:LPMP_356050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350068900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_356050"/>
    <dbReference type="eggNOG" id="KOG2877">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="196717at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004142">
        <property type="term" value="F:diacylglycerol cholinephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004307">
        <property type="term" value="F:ethanolaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000032">
        <property type="entry name" value="Choline/ethanolamine phosphotransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF37">
        <property type="entry name" value="BB IN A BOXCAR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015665">
        <property type="entry name" value="CHOPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO02734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="417" mass="46725" checksum="EC5CE451408BE9F8" modified="2014-11-26" version="1">MPPKMTARRKSLNPLENEYISPAYLPNLKKYKYSSTDFSIMSRYVLQRYWNFVVNLVPMTVAPNCITFTGFLIGMSSAVMLLYFFFFEEGVYPSWSLYYASFALFTYQTLDAIDGKQARRTGTGSPLGELFDHGCDAFLTPFVLLNVSLVTYMTPVERFWLLSFSSFSLFTIIWEQFSTGVFVLGYVNGPTEGIILNCVLFIVSGVYGESIWDTPAVGPYDVAYPPALAWLFPGSSGVVHIESIRSVLFLIYLICCLFTILTNVIHVVVRSTVHDSKVTPMLAAVPILSMTALMVHVSVVFSNLKVHFPFALEMSYGLLVSITVTRLTLARLSLMPYKTTNWHIVLLFIALTTALVLHYAGNASMPHEVVERVLGWSLTGLSVFAAVQYGHMILSAFTQIARYLNISIMSIKPKKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3N5</accession>
    <name>A0A088S3N5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dienelactone hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_356730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703601.1">
        <property type="nucleotide sequence ID" value="XM_010705299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3N5"/>
    <dbReference type="GeneID" id="22579701"/>
    <dbReference type="KEGG" id="lpan:LPMP_356730"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350076900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_356730"/>
    <dbReference type="eggNOG" id="KOG3043">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2147163at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="29"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="240" mass="26246" checksum="D200B54714891B1C" modified="2014-11-26" version="1">MSSEDPNRCCPTEKGPAKCDYTPVGGDFYMVGPHNSKAGVVVVSDIFGMLANSKRLADMLAEQGYLVVMPDFFGAQAWPMSEWPADFESARWIQHKAKISKFDTFAPRMENAIALLRQMGCAKVGIIGMCWGANLTFMMAAQGKIDAAATAHPVNLTSDNVKAAKVPVLVMPSKDEPPMDEVEAAIDAHSVAPHVYVRFGSLPHGFFGARYDPDAYTPEERKDVETARGLLVDFFNKSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3P6</accession>
    <name>A0A088S3P6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Organic solute transporter subunit alpha, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_356880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_010705314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3P6"/>
    <dbReference type="GeneID" id="22579716"/>
    <dbReference type="KEGG" id="lpan:LPMP_356880"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350078500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_356880"/>
    <dbReference type="eggNOG" id="KOG2641">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO02816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="372" mass="42551" checksum="CA9518B2F47A3284" modified="2014-11-26" version="1">MGLFSALQRWKTERRKMYYWAGTFACVVGLLFFIYIILSTVLKNQSVVPNFVAGYCAVFAALLSCFQILEHLTCFSDPECQTKIVRILFMVPLFAVISSISLLAPGAAEYLNLIRDTYESYVIYAFFQLMLALMGGIDTVYRTLMIEDRPPVRQVFPFCYLEPIKVTPTFVQNCRLCLFQFMLLKPLVTIIVVILTAKDAMGSSMFDLTKGRFWTYLVYNISITVAFTALLYFYMGLKDLIEGRNVFLKFLCVKAVIFLSFWQGLLIQLISAAGLLPKLSYWKPEDTPAALQDLLICVEMMFVAFGHKYCFGSDEYLIHNVADGCVIEDISNQDGLQTRTIPPIRYSVAENLKYTLRHEDVLTDVRDIVHNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S433</accession>
    <name>A0A088S433_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_110010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696849.1">
        <property type="nucleotide sequence ID" value="XM_010698547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S433"/>
    <dbReference type="GeneID" id="22572866"/>
    <dbReference type="KEGG" id="lpan:LPMP_110010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190008000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_110010"/>
    <dbReference type="eggNOG" id="ENOG502SPFE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265801at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="59"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="176" mass="20504" checksum="68D84289E2A62774" modified="2014-11-26" version="1">MTRLQSVEGQLKECSRIRTAAPVSELSERRDFERTSVNCELAEKLRSCENKSTSLGVKNRELRREVVVLQAENEALRRQRKIDEDTLVDLQKLVDECKQKEHRLLEKIAARELATGTLLREDEFLEIIRSSQQQLRAFYEDKISTMQDEMDRFYSHASACIREKNAIIDTLKSESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S435</accession>
    <name>A0A088S435_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_352280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703165.1">
        <property type="nucleotide sequence ID" value="XM_010704863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S435"/>
    <dbReference type="GeneID" id="22579257"/>
    <dbReference type="KEGG" id="lpan:LPMP_352280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350028900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_352280"/>
    <dbReference type="eggNOG" id="ENOG502SH76">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267534at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="590" mass="64855" checksum="56D13BE5DA064ED9" modified="2014-11-26" version="1">MSNDMCAGVPRVPARGEDMAQGGEGCDEGSATRPIAVRTGFLPRPGSRYVSTASRQQQQLLELATMPQYPFPPLNRATTAPEDEIQRSALGRNMEEDEETDADDETGEEDGDGRCGYVMQSDPLRVSLDLAQVRKVASLARTAATVAADSDGAVQQAEEAEAILTGAQEGSASHCHAQLDDTNTCSLEAECDVREVSKARARLEKRGWDDIHRRAMQAATTPTPPSELLLDLLQHLPSAPGRAIYDRSNCPPTTVASGFNEDFHKCVQKLMTHVVLQRDGRTGNAEPPSIPVAGAAVAQQVNASPGPRGSTQRKGARQNPKVAETEQLAEVVERGIAPDVRDVVAYAQFVMQERLHQEQRRKSNYRSTLLRTAVGESGEDRCAEDGVRANVDVLTSDQHQQLAKLRAVVEKKLSLMRTAAEATDEVGEAEREALRTQRTNKKRGNEDGSNEMLLPNDVTPQEPKAVLVAAHTRFMDVVRSAAASRREKVEATQAAEQRLEAAVATWRKSYDTLLTRERHRHQAGQRQDKQSRVEALLQALQLQQVNPQKVQRHQPPADLWGMAKGMRKKERKHLNKLVKAANAFPLPPFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S4L7</accession>
    <name>A0A088S4L7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L22</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_353350</name>
        <name evidence="7" type="ORF">LPMP_354530</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703272.1">
        <property type="nucleotide sequence ID" value="XM_010704970.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703385.1">
        <property type="nucleotide sequence ID" value="XM_010705083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S4L7"/>
    <dbReference type="GeneID" id="22579364"/>
    <dbReference type="GeneID" id="22579481"/>
    <dbReference type="KEGG" id="lpan:LPMP_353350"/>
    <dbReference type="KEGG" id="lpan:LPMP_354530"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350053600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_353350"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_354530"/>
    <dbReference type="eggNOG" id="KOG3434">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275442at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.210:FF:000004">
        <property type="entry name" value="60S ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002671">
        <property type="entry name" value="Ribosomal_eL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038526">
        <property type="entry name" value="Ribosomal_eL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064:SF0">
        <property type="entry name" value="FI24544P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01776">
        <property type="entry name" value="Ribosomal_L22e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO02472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO02585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="129" mass="15054" checksum="E53AF9631CD3DA70" modified="2014-11-26" version="1">MVAVRAKVGSRSYVRQKQLVKGKKVFKIDCSIPAADGIFSEDVLGNFEQFFHDNTKLNGRKGKLSDKVRLSMNDNVLTITTTMAYRKKYFKYLTKKFLKKKDLRDWIRILATGKGTYQLKYFNIQDQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S516</accession>
    <name>A0A088S516_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inosine-guanine nucleoside hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">IG-NH</name>
        <name evidence="3" type="ORF">LPMP_140130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697249.1">
        <property type="nucleotide sequence ID" value="XM_010698947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S516"/>
    <dbReference type="GeneID" id="22573280"/>
    <dbReference type="KEGG" id="lpan:LPMP_140130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140006100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_140130"/>
    <dbReference type="eggNOG" id="KOG2938">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="432381at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02649">
        <property type="entry name" value="nuc_hydro_CeIAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.245.10:FF:000014">
        <property type="entry name" value="Nucleoside hydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052775">
        <property type="entry name" value="IUN_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46190:SF1">
        <property type="entry name" value="SI:CH211-201H21.5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46190">
        <property type="entry name" value="SI:CH211-201H21.5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="352" mass="39067" checksum="173AC1CF246CF782" modified="2014-11-26" version="1">MPRRRIIIDTDCGGDDAIGIMTALADPNTDVIAMTVVWGNVNADQGMENLGKLLCVFERDIPFYKGAETPLVSDPETVQWGGFGKDGFGDADFPPSTRVPEQSKTHAALAITELLRTAKPEKDTVYQLVCLGPLTNVALAMRLEPGVFDVLGSETEPAITIMGGTSEAKGNSSLTAEFNIHCDPEAAYVVFNQRNMRPVRVVSWEVTVECCMTWTFFDEWLGRQKDGTKEQNRLQVFIAKVFQRLEAFTRPLPDGTKADAGDAEVTQDNTCVIPDAVAMVAALYPDSILDRFLTHCTVELHGRETRGQTCLDWYGTEQSMAKRGRWRNCELITRVDNNRFLEVMNGIIKHPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S5F7</accession>
    <name>A0A088S5F7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar protein 14 C-terminal Fig4-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_141450</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VAC14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697374.1">
        <property type="nucleotide sequence ID" value="XM_010699072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S5F7"/>
    <dbReference type="GeneID" id="22573412"/>
    <dbReference type="KEGG" id="lpan:LPMP_141450"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140020500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_141450"/>
    <dbReference type="eggNOG" id="KOG0212">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5574975at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070772">
        <property type="term" value="C:PAS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026825">
        <property type="entry name" value="Vac14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021841">
        <property type="entry name" value="VAC14_Fig4p-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023:SF0">
        <property type="entry name" value="PROTEIN VAC14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023">
        <property type="entry name" value="TAX1 BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12755">
        <property type="entry name" value="Vac14_Fab1_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11916">
        <property type="entry name" value="Vac14_Fig4_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Vacuolar protein 14 C-terminal Fig4-binding" evidence="5">
        <location>
            <begin position="457"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN96721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="686" mass="75171" checksum="8B7EACA2691E2BE8" modified="2014-11-26" version="1">MMADPLALQATRKALIEGKADARSRAAQAISSRTLQLYKDVPTTEAEEVLVLELRSVGDQLLRNTAAVYRRAGLICVRAVCAGLPHHPLGSNLLIHLLDPVLRSMGDADPIVRIAAIEACYELVRHHGVEAWAARFADLFTALSIAVSDRDKRVFLLAEEVSCTLKESVSRSGAAAVDINAFASFVCETLGSHTSSSRSLVVDVGAAVSQWVLQWLRFVLELPGCHFAASMASLLRVLLAASDSNDTNVFDILCECRQGVSQHYLAETAANVCEVVDILCTSVHDATSARTRVFCLEWLSELVHLGIGDDVFQRHLSCVLQATLPELSSHDGATRAAAVTANQEVQHAIVPVGASISAGVADLLLRSVLELLDSGAGEETLIGGLEWLLILHHLAPSTSENLLNTVLETITVLLDVAAESVALRATEVACVLTSNGHFSEVVQLVLQRLLHHNRDGLLLRRFPDVVRRLHTLRSRLEGEDLRESVLVHFARALSDITDLRFVSKVVLSLQSMLATFPELDDVRVLLRRGLTNSATAEMFSALLQCWRYNAVALLSLGLLCRHFVFTRRICEHLGEGEMSVATYVQLDHLVQQLESSTFTFLRVSLLRPMSCPALVQTLYVLLLLLPQSSPHYAILSQRLQPVTVLVQLDRMASEPLTAEAQADVPESDWDHYIAAQEALLQYEQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S5V0</accession>
    <name>A0A088S5V0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_160420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN96916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697569.1">
        <property type="nucleotide sequence ID" value="XM_010699267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S5V0"/>
    <dbReference type="GeneID" id="22573619"/>
    <dbReference type="KEGG" id="lpan:LPMP_160420"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160008400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_160420"/>
    <dbReference type="eggNOG" id="ENOG502QUYT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273529at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="546" mass="58951" checksum="42A5A579FB318AE4" modified="2014-11-26" version="1">MVGRAAATTSACGAQNACATHLVARASLLVSFSGLGAYSRFRGATRKAVGAAGDHRRGIVSCTQALFLGGKRQFSKLEAISLEAESRARLSDPIGTSTLELNLLEDPTAGLATGPAEELTPTELETRVRVLVSGYTPSLYRLLYMPFIDVVALLVKEGLVPTADAEVLQSSSPSASSGSVTTTTGGMGAGTISTSLRPVRPEEIMARWFTDGPATLKRPHATAEAMGKRRWNAFCRALEAHWASFEDVMPLTRVVQRHHLREELYIPLFRQLAMELVDPTKRASAVATLPGIILSLANGRAPRSLGLPENDTERVRLVSNLFLGVAQEAGNTDLAYLAVQLLRANNLTTPFSAQKQITNAFAAASRIETDWQMRATSLLIESYPKWLEYFRRVQLDNMVALEALQRGPAATTSSESAGAGGSDVTTAAPKSAKRASLPDKRHGKRSKGRTADSRRDGQLADHSPEDTGERSAEQYRYFTSRQQDDVTRVTALEANIEAALRSRVSELREVQMNRRRKKSKEEAVPSGTSSAAGAERGGRSSSKGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S7I5</accession>
    <name>A0A088S7I5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_200540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698253.1">
        <property type="nucleotide sequence ID" value="XM_010699951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S7I5"/>
    <dbReference type="GeneID" id="22574261"/>
    <dbReference type="KEGG" id="lpan:LPMP_200540"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200009700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_200540"/>
    <dbReference type="eggNOG" id="ENOG502SMN5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265987at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="647"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="677"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="694" mass="73271" checksum="1971A36C5B573393" modified="2014-11-26" version="1">MGSCCCVSDSADDAEATVPLPPRKTNITAQLPSPAYPSLSKPTVDLTPESPPGPVKRSLSTISVLRMNDTKEASRTATPAARPDAIKQHHTTSFSSSTPAAGPPAAQTHRNMLTSSPLRLSPTLRVVRENEPSDNLDAVVFSDPEPMSTKKSTPCATEEIHQIMPTAHRSESETAKQLLVAAAVPTPSSADVTPERATDPTAIPREEEGRTRGPSTAQVDEVPPTPKEESNKALPADDARVLQRAPPPPPPPASVSPVTPMEAGQDGEKHSIDEVHQTYQEATNSATRKDSVTVADEDEEGAEGQQESNPLADIIRTWQENQKHHPTTLSIEAAEDAPLEINRDKVNSPLSVATEAHAKGKPSRPSPLPPSESVNGGNLNDSDDDVKATPKASMATTVATEQVDGPTSDPVYNNLQQHQWSALTKRGELHGILSNKRESHTNLTTSEQKPNAAESSCADEAQLTQQACSIMELSQMEPISWSKERLPEGTPLQGKNSHEADVSPSLYHPRRLGTDVPGRTECAAASEVTCKISTAAAFSDLFSGETKVEEQGVARGHGDDAEKPIIFTATSERGRELEAVEVKSNHVEGTPTMDKVPVHTTGNTDVVDKPQSIAGNAVPSVALGASIGTADQPIASPEQHATSALQAAENSASGGAEAPHSKPPLILCHSSDEAHATPPPSRPAPPSIMSPSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S7K4</accession>
    <name>A0A088S7K4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_200790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698278.1">
        <property type="nucleotide sequence ID" value="XM_010699976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S7K4"/>
    <dbReference type="GeneID" id="22574286"/>
    <dbReference type="KEGG" id="lpan:LPMP_200790"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200012000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_200790"/>
    <dbReference type="eggNOG" id="ENOG502S0N1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270967at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="469" mass="52289" checksum="0D64866C2E215A1D" modified="2014-11-26" version="1">MSQFGRPQAPYDWGAGVRVRVQRACQAPYFSLFREENTRQADAVYEGRLSRAGAGAYPAIKDDGQRLLYFPYRNAESVYCTTAEAAGVASEVVTLVGATGTVGKFVAEQYLRRGVSVTVLVRDTEKAKSLFLPIADGQRERNRSASMGYIYLGGAAEKRELTESLDYRDSRRGDRHVLRYEFRTSHSVGGSSAGNADISGNQRVTLELIEGDAGSAEDLEFSMRHASVVFYLAAAIEEAPSPALRADGCPSSSAPWWSPGSRFGSGRRFGSFLHALDACRRVDAHFVVLTPLWVRGSRLSPLYWYRRLVAYPRGYCKAVQLQEQTLLSQNGNPNVHCYFGTEELEERQSGGAWNSWWRMWLSTEPHGDLLKLRSPVRFSLFRLSDIVFPSFNERIVAAKNNRVDDDFHTKPIRQGDLDARLLANVLVKSIGLCNSVVASRIDVGGCMRDGTDMRDSSAVFDLFEQLRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S9E8</accession>
    <name>A0A088S9E8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Letm1 RBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_211780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698963.1">
        <property type="nucleotide sequence ID" value="XM_010700661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S9E8"/>
    <dbReference type="GeneID" id="22575000"/>
    <dbReference type="KEGG" id="lpan:LPMP_211780"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210021800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_211780"/>
    <dbReference type="eggNOG" id="ENOG502RX9Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268525at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="394" mass="46506" checksum="ABD15EAB6C148D43" modified="2014-11-26" version="1">MQGTWGVLKRNCVNFIPGLALFASQSREAFTTWMKIYNRGYQYGPQDFYEQAEVYTPDYWKRGHSQDKNMWVDMKLSEEVSQKELAQLMHYKLDLWRMAHGLGVGLFLGGYALIPAFFWLSSDTFSPSCFCKTEEEKKAWREAQDMYRYRSAPSYIMDTKWHFDFHAYPWNPTQERAWDDLFEKNNVRRDPKVLRPAAEMYDGFLQFYQIRRKSLRHLARSMNFPTFPLLSRTCASTRVKDYWNLAWNEDYMVITQKLHSQMSDEDLQDYAWRRFLAPYDKNLSREELMTRVNDYHEFLGHKFVEEGKAPNLIILTNYVLGYYNDPAYLVEDISALDGNDFEYMAHYGKDAFLRRLEFENGPLRDQVEAHTQKLIADRAAAAAKAATKAPQVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SA80</accession>
    <name>A0A088SA80_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_231010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699258.1">
        <property type="nucleotide sequence ID" value="XM_010700956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SA80"/>
    <dbReference type="GeneID" id="22575306"/>
    <dbReference type="KEGG" id="lpan:LPMP_231010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230016800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_231010"/>
    <dbReference type="OrthoDB" id="268003at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="873"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="903"/>
            <end position="914"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="993" mass="106891" checksum="73FBC40E81F2086A" modified="2014-11-26" version="1">MMDRLLLEQSGRAHTSGAVNRTEATLPIARHALNNGESSRPSSGERYVNASAEGLRRAPCPSPLQLLASPVLDTRRPVGGDAAAAAAQISRATGLYPSRRLTPIHDCEQTAVRERHLAVAAAPTLPSRKPSGSPTHSASSNDIGTSASTPFAYTSLQHRKVPSPALYPVIPEAYRDEQLHHHQPDGGGRRYLTPPWWWRGGLEEREEDSGLVRGVAHHFNPSMSQRRAGTGNLSLRTAQARRDHGEKRWLSSPSAPTSPPLRSRPPSACEERPPRPRSPLASSHARLYTSSKLQEAEGDVSPLTFVEPGAYRFDDIELRITRSGDGPRDPCARAHQPVRQFGRMSSRYSLRHGSLPASPSMDLAQPRGPSSAASSSKTTPSGSARTVTTDSGTEATSQCTALSNVLATSSGSKFRLRVYQESSNHPSGFAVPQRGAGTAAPVQAIRSGLAALPQTAADRCAIERATNAIPRSMIYGSSNHASALALVAYRQGVAAETGVDPAQLRQGPLSARYDRVRSGMREVVVEQADDYGGGGGGASLMHTATRLRVGALRTRELYDPVSGLARKPNEVPAAYLKSMVAAEAARKHLHVTPSLQAAAATAVPYRYDSVDSSASSDASGNPSVLLKRGQIKSGLSARVDTLSRLAQRRRQRANARAAQLHTTHGVTGLPLRPDERRLYWAEHVPLHAAPVRGLNAVLQGVGEAEEGLFFESAGMRGEWAERESSGKGASWSGTDVDMCREGDTEVTLDHPHASLEESSFDDDGADHEDEVRLAAGVAGSHRRGRKGRGEFQVDSAPLRHARLSPHAVERCPFFSASPAMAGVSAHGSRGVAADASLAYMERLNGLVDSDADGGTTFTSVGDDMRTRCLGHDGRSHHRTVSGHHTGMPLAEQSRGTLPPRRSHPQDQPEYNRHGDEDLLLYPPLLTPLLQEVDACLRFHGLPTMAELWRWGVGDQEVILQAAGFKRVERQTILWELERMIRVSSTRCTVPSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SAW5</accession>
    <name>A0A088SAW5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_241540</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699493.1">
        <property type="nucleotide sequence ID" value="XM_010701191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SAW5"/>
    <dbReference type="GeneID" id="22575563"/>
    <dbReference type="KEGG" id="lpan:LPMP_241540"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000010500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_241540"/>
    <dbReference type="eggNOG" id="KOG0123">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6159137at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009967">
        <property type="term" value="P:positive regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001249">
        <property type="entry name" value="RNA-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000383">
        <property type="entry name" value="Sex lethal, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="231"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="320"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="442"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN98786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="682" mass="71749" checksum="33AEB03CB9036123" modified="2014-11-26" version="1">MQPPHTSTQLLPQDSPPDLSNLTTNAFSPLPSSVGAPSTEDRQQQQQTATVHFYGDSQLESFMRVAAGDDKSSAMSPEPAANNLLGQLTVSALAVQNAAPASPPQPKAFHLHQFTPLGASACSNVSRSSAPSHGSGSVQMGCGPQMYSGDTSFPYPNYIKEALSLTPSQSVHSQPDGFAAGVVTPPTTPMNSSTINDNMSASLSQVMIGGAAMSSGVTMPFSQPNDAEVRSNLFVCGLPVSVRDKELLELFEKYGEIESAKVMLDIHTGRSRGIAFVKFKSIEHAENAVDTLNGTHINGHQITVRVANSRAAYLPGNPTNKTFVRNVPLTVSRSTLFDYFAQFGEVTDLSIKSDTAQGRHNQSGRSISTADDSTDDKLNIVFITYSTKEAAAKAAEATHTKTPFKECKGVPLLAKVAEDTVRRMERLSRRQRTTMGAEGTRDANTAGSGGSITSMGRLAASSLGAVLPPGMMVSPMMAMPDSFPPGAFVSVPTMGSPPDLTAPTMMSSNMAGDHMTAFCDVNGSTIYSSAPPNPTAAASGMAYAMPGNMAQPSMFFSAQPPPPLSITQSAPPQPQQIPPQAQPHALYMATPNGFATAPQPQPQPQQQLLQFFPAPPPLLPVQQQSQSAVPMTGATPGQLVYMQTANGSVMPVVYGGAQPAAGPMLPPMSPYFVMMGGQQLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SBD4</accession>
    <name>A0A088SBD4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNAj-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_251130</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699683.1">
        <property type="nucleotide sequence ID" value="XM_010701381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SBD4"/>
    <dbReference type="GeneID" id="22575761"/>
    <dbReference type="KEGG" id="lpan:LPMP_251130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250017500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_251130"/>
    <dbReference type="eggNOG" id="KOG0712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000013">
        <property type="entry name" value="DnaJ subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839362" evidence="6">
        <location>
            <begin position="25"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="54"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="8">
        <location>
            <begin position="174"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="5">
        <location>
            <begin position="174"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN98976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="395" mass="43806" checksum="900E6FC16C50066C" modified="2014-11-26" version="1">MLGPRTTRVVVALLVLAWVVTLLAEVPLVAADAADPRDEDVKAVNALLQLPEDDFYAVLGLGEAREDSTERDIKNAFRRLSKKYHPDVATGDQDSYRLVYQRVQRAYGVLGDRRKRKVYDILGVDGVAKMEKPQQEQHVNPFFAFFGVGQDTNGERGKDMELLMVVPLEDIYRGAAHTSRFAKRRICRACKGTGARSAEDVVKCPHCQGHGRLVQRVQIAPGFVQQVEQACPHCQGKGTHVAYMCPVCGGKMVRPGEAVLSVDIEEGLPEGHVLTYELEADQTPGQVPGDVLVTVVSAPHPLFRRSGNDLYANVSITLKEALLGFEKTLAHLDGHEVELHWDGVIQNTQQVRITGEGMPRHHVPSERGDLYITYNVVLPSELTAEQRAFFQEHFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SBJ5</accession>
    <name>A0A088SBJ5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1935 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_251830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699753.1">
        <property type="nucleotide sequence ID" value="XM_010701451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SBJ5"/>
    <dbReference type="GeneID" id="22575831"/>
    <dbReference type="KEGG" id="lpan:LPMP_251830"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000017400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_251830"/>
    <dbReference type="eggNOG" id="ENOG502SH9G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="274785at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015232">
        <property type="entry name" value="DUF1935"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036310">
        <property type="entry name" value="Smp-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47047:SF4">
        <property type="entry name" value="CYSTEINE PEPTIDASE, PUTATIVE CYSTEINE PEPTIDASE, CLAN CA, FAMILY C2, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47047">
        <property type="entry name" value="PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09149">
        <property type="entry name" value="DUF1935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101601">
        <property type="entry name" value="Smp-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1935" evidence="1">
        <location>
            <begin position="16"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="139" mass="16338" checksum="5527F7572DCB220A" modified="2014-11-26" version="1">MGCGYSTYSAQDDIVWKYGGPPEEPLKALKMFPKHQNGLLFRLLYDDGERWAFYNDTLEYEFHIRYYFSSDSDIEALHNATLSELENGNKLVEIIVYPKETQDFIVGVAGSYTSTIEAIPITERFQWERSKEKYEQKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SBM0</accession>
    <name>A0A088SBM0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NPHP4 Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_252080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699778.1">
        <property type="nucleotide sequence ID" value="XM_010701476.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22575856"/>
    <dbReference type="KEGG" id="lpan:LPMP_252080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250022900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_252080"/>
    <dbReference type="eggNOG" id="ENOG502RGFA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271255at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058685">
        <property type="entry name" value="Ig_NPHP4_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029775">
        <property type="entry name" value="NPHP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31043">
        <property type="entry name" value="NEPHROCYSTIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31043:SF3">
        <property type="entry name" value="NEPHROCYSTIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26187">
        <property type="entry name" value="Ig_NPHP4_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NPHP4 Ig-like" evidence="3">
        <location>
            <begin position="1248"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="454"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="820"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="881"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="280"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="480"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="820"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN99071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1342" mass="146087" checksum="64A5E5056D83D346" modified="2014-11-26" version="1">MPHSGSAAWRSRSAEQTARLLLSNAFRHDTWECAAARKQVQSHGGAVHTLRLRFLELTKQPVMPSDVEAVNLAIFDPERKMFVGATYQLEARDMTRSLAVQVAPTQLLVVETVVQDIRPSAPLEEYRVTRWGFCPVEEVKSGTISVKLRPGSAHLLLVEMNSWPAVSLPTTPSDVALICDVAMDQDTALTQLMGELVPPGIFVSEDFTRATPTPGTSLFRLCVRSIELSGSTKESALNLADPDAEWSVAAVAHNGFQQLGKGSEVSLVLKTSNDGGQRNSSSITSSASTRRLSAAPDANTVLLRSDLPLEIDRLPVHSATSLVLAIRRRAPGSRIFAVFGFCVLPLCMMPMRDRDIRVENLPALKGPFSCEDARLLMVDSTSSYGRVPIAVTLTVEYHDTGISAGAPPAGAVAATSAVAAQQQPEEITKDEVSYSSLTSSASSVFATPRPTQVLSTADVPGGGVAVGPTSYEGLPTPTESGAAAAPGLSAPDSGDSVGVFKLLCSIMEELHKVRESQDMILRQTRGEGGSSGLSALSPALQERLNRGLADGRIDVIDLAPRPLAVSWRALKLMQEGVQPILHPLHGTLLDDTAPALGELTSSLYGFRVEGITVDNALHMPADVCLLFSFGPLPHQQVGPLHAVSVEKTPTNESFKVYDDRHEAGFVWCEPTEALQSGAMRKYKSASNATVYVHLYDALSMFYVATASLPLAAFRRPISAMCAMTSMDVVLQRDLSMTEQVVPPKVFPVMRHAGQLHLTVFCVGISVASGDERSCAAALATVRLPENVQSRVIIAKKLRHADRLSPTGLITGSSAINGTAVTNGGASASPTTDASPGKQAKSATDGAGTLHWQRAQYFKAQQREQQQSVGAAPQLLGVPDTHVQAAQAAAELEYRLRHLERERAAVKSQRIAEALLNRLTVEHDVLVISWRPEVVRTPFANPFSCAMEFFVEVDQRDTDVCTVIGASNFVLGPRERTELPLAIRLSIPRSVWSKPGSGANDQQLKQQNITARVYSEKRELACCIRIHATVEPPVVDRRYEIFGAPGTEVVKSILARTFSPASFPVISDKTALLQRMRELCAFVAVSGEKTSVSTNVVLDPITQTYVTAWEEATMTTKIPEETGRQRIEYVALFYDAAMSRLYETWEICVFACDSFMTRDIYWGQTTALGLPAEGTSDLYCSDTAVTVERRGASYVLRLHPRDVGTQRMLLHTLQNDVLKKTLLTVSTVHPTPTYTQVMELSLAEVQGPVLRRLTFVNRGEKEEAFQVNHNYRFNLLVSPSKFTLAPSDTQFVSLQFDLLTLPPGQLEGRWPVWIFINNSEDKTVESYHLQLVVRAHPVVRVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SEL6</accession>
    <name>A0A088SEL6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_292650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700869.1">
        <property type="nucleotide sequence ID" value="XM_010702567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SEL6"/>
    <dbReference type="GeneID" id="22577028"/>
    <dbReference type="KEGG" id="lpan:LPMP_292650"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290029000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_292650"/>
    <dbReference type="eggNOG" id="ENOG502RYK2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276144at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO00212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="424" mass="46185" checksum="A735425D3B153728" modified="2014-11-26" version="1">MRYPYDASKGFAGIRQREAGRVFNGYGPSAVDDMMNSLMDPSVSTEERTRAAHLLYARSASQETKIEMLKKGLVPMLVATLQRCPDHLLKHQCLLLLRSLGVLPQGCFALVREGAISMVAAELRTDSPSVASLEAAQACYVAAAHVLYQVSSNMSGLRWMLGLSHDPAFEGIEAALVEELLSPEALVSFIAGGLASEAMPATATVYLVQTLARLTSLERGVEAFLAVPGAVDILVEYLRRLPNLPTQDTELCSVTLEAMWNTSLGPVGRAAMEERGVPDILFELLATTSGIVAQVPVCVQRQLTGALSAVSQLTSVKQRSTQAVSSAEARIRIVVLVDYVREWNTLIATQYTNTAKPVPSAAAAVVTNVVQCIRLASELKPVRDLTYAILDAMEQEGTSEAFYFRRQLYFHTRWEAEFRASVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SFV2</accession>
    <name>A0A088SFV2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_310680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701457.1">
        <property type="nucleotide sequence ID" value="XM_010703155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SFV2"/>
    <dbReference type="GeneID" id="22577494"/>
    <dbReference type="KEGG" id="lpan:LPMP_310680"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310012000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_310680"/>
    <dbReference type="eggNOG" id="ENOG502SIPX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265702at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="484" mass="50402" checksum="B2361243DBE6BB27" modified="2014-11-26" version="1">MQQPCSDMDDATGEAYVDIRVCDLLVQQGNMPKGLDSGFPIDGLYVVLRCREEVRRTSCLWPSVSGASAKERQSSDTQPDVAAGTLEEQNEDDLVWNEMFRFVVPPALQPIAPVATPLGPHSPPSAHGGDSQGGFCAPYTLPFHPSGSSNGTDGGARGLPYGAALPMCTSAVGGIRGPDSSGFALSYSPPPSFLAIPTSPLRSAVAQPQPSGGDNSSRATEAGVGNSPSHYPSIELELWRSTPLSENLLGCYTYHLPIELMQGGYDLSTLDAVVERVVLLRTKEAPSIMGNLYGWSEHRLSLRLRVQAVGLAPLMAAWSPQQGSKAMPMTAANMTGSGAYPGPFSAGMPDGTVAGASPYAAASVYGTTFGTLNPVLANILAPLGVSMGGSAVQHVPPGGMMSISGGIGGDHLQKPGEPPFLSMLPPFQTAAPVGGRLFHPHLPGAPSATPQSPDQGILGDGDLTWQSSITQPTVYSPYGLPQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SGE2</accession>
    <name>A0A088SGE2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cilia- and flagella-associated protein 43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_313050</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CFAP43 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701687.1">
        <property type="nucleotide sequence ID" value="XM_010703385.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22577731"/>
    <dbReference type="KEGG" id="lpan:LPMP_313050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310038900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_313050"/>
    <dbReference type="eggNOG" id="ENOG502QQ39">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="64353at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056297">
        <property type="entry name" value="Beta-prop_Cfap43_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056296">
        <property type="entry name" value="Cfap43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14885:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14885">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 43-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25828">
        <property type="entry name" value="CC_Cfap43"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23185">
        <property type="entry name" value="CFAP43_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23184">
        <property type="entry name" value="WD40_CFAP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Cfap43 N-terminal" evidence="12">
        <location>
            <begin position="10"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Cfap43 second beta-propeller" evidence="11">
        <location>
            <begin position="322"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="998"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1182"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1431"/>
            <end position="1458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIO00887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1471" mass="162894" checksum="EFEB483A5AB41FE0" modified="2014-11-26" version="1">MVMLQSVARVLGCSAPAVFAVHGNRVFVPADNGVVVVEDGYEYLWAPFPIGKYSIDKIAVSAEGVLCLAEKRLHVALHFFDADSMQSLGVAEAEVFVSIADIVFSADGKELFVLGTVPDTTVTIFRRSTPNGSYSLADRVPLQHSEEPKGLLAFGFEGSVLRFGIWRSGCIAGYAHGEDGKSFQKCFSVEASIESACVSGPSTMCYITKEGSLHVYSHESRTFQDVCEGLLAPAAASMIVWDGTVFIFTRSGDLLSVNLCDGTHHRRSLGCLPSCTSRIVVTSAAELLLSTQRGLLAVTVPVVTNGGAADSRLVKGWTEASTLRCLSVNNGASAAWVLRDGSIALYKRDDVRVLTPCGVRRAAVHACILNSSEIVILFEDGTLRCFDCVGEREVWSHQCLEWAPTFVEADGSGTVACCGRDALRFLRCMDDGVEDRGVIRTTLLASICLVRWVPMETCLLVVCQNGDAFLVEVPKDGDAETTHSAEAFVRSSWRLDFPITDALVCYVTPDILNLFVHSADHDSKVYTLDRQREGDGKVSRPLFLIHDHSSGGSCLLRLNDSTVISCGRDGSIAARDLTPYQTQMTPIPPSREKRKPLWVHAVRSSFGGGITTVATTDTGAEVICGGNDGVIQCVTLKAEGAHATWQEPQWTHAEAARLGIVGDKIAAVQAGDAAPEREALLLAVSRVRELWMKVMSDKDTEVPLEAFLTPEQRDQFAAECDSAVFDMREGHYYHAILNEYLQDTLRRRCCEAMEVTRMKVVSMNTSELEVHNFHIHRRTRAEASLSRKALFLRQLQKKSAVGRRTVPGLQIMSKTATPADGSSSGTEDLDAAMLNDADVYTQSRMVLQSLLVKGRSLALKDAFNTRFTDLQDLKRQSMMQVEERTLRCITIGKQLGSLPAQLFTAVVDPEEDPNSLFVVEDKELSAEAQALIAPSMGATVVSPVDEAALPLWMDGLEKEVVRLEVHVPLPDFADDTRDTFIPPEERTEEQTRIIEAYAKRLKEENECVEAKREALRGEFKSLQEKNRETAAKLDEQLHQIRQLRLNTAEEVDEAELQLALLFQHRLCVSAAYRQHQSLAQKRETLRDGRTEAESTVAQQKHLLRAAQARLAAAESKTGGYAASVRALAPFEDGTTGEKLHRRFVRWQRRFVDGSAALPDADTSAADCTAEQWAAFCDHCQAVAELQQLVNDAEAEVQRAAVDVREAQRHCKLITDEIDVTGEAMAAVRGSSVACLLDVHALCRLRQGQIQDEGATTATAFLSSNLRWRDDVSQYNDLILQSEAESRALLIKAFAQQKLMRLLDWDTERLRYCTGTLQLELRQLHTLRVTRQMQEWLSGDAEVSEEKMLAHLQRHMDMVEMNMSRKIEELRSVGRRLKSQIAERVTENTIVDAQCDDLDDTVRANTAVYRLMETGADSLHARAARAKEIFCTSELEELARSQQEELVRLKHEVDRLRERTFPSFAVVSKQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SGJ5</accession>
    <name>A0A088SGJ5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_320500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO00937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701737.1">
        <property type="nucleotide sequence ID" value="XM_010703435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SGJ5"/>
    <dbReference type="GeneID" id="22577791"/>
    <dbReference type="KEGG" id="lpan:LPMP_320500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320010700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_320500"/>
    <dbReference type="eggNOG" id="ENOG502RY8T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="333024at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="877" mass="95515" checksum="A2E4A9FF027ED039" modified="2014-11-26" version="1">MPLMNCKPMMDRLRGLVACGASEATANNILAQFLGASLKLEELCLVDCTLTNTAVALVEAVTRTEMKCLSLERSNLGVGSADSDGTGLAASFCEAVKVNKFLTSLNLANTNLDTDFVVALVDALIESDTKLLPEDLGEDPEEVTEWSLEGRLNDAMFISGAGPDDGNAALTDDETVSDDDDATPSPDASESGASEDATGDNESDDEEAGVDIEDEDCSEDDEEADHMTKAQEQRERQEKEERQAQQKRIRQQLKVFSQSEVQERSKLAHEYCQELRNVVAANSGPIANRRAAERQQKKEEYCSRRSGWSRLEKLVLRGNQVGDRGCKRLACVLRDEVPLSEDEATQRLEAISAVRDRFGERLGATRSAVVREEKKAWRALLRKAQRESPAFVTARSTSISTALSDLDEEDEYAKEAPPVLLTNVERPHSGSSSLDGDPASDGDGDTNGSSDFTSEEQREWQEWAAQALPHVSVALTKKGMTTIRVIDVGSCGISRSGVQALAEVLKTNKVLEALCLRHNPIGSSAPVKKRAQPVDGVAIFPEFAEFAEMLSVNRVLCHLDMGYCHLHPDDVRAVAEALRQNTSMVTLILEGNQLGVDEAYEQQRHAHSYIYELWMTAARPGSALCNLNMNHNNIAACLWQEEVAALAAVCGQLTSLSLSHVGLQLRHLQAWSEALPPADASYSPTVRILHLARNELASEVDGAALGLLLRHFTALEELSVEENPLLGSSGMAVALEYLPVTMRRLNCIATGLTTPCVGAARNPVLPVAVAEKLTCLLLGDVEAPTVAGLGEWVTFLKRVAPHQLQLLSLWSRGMADREADVIPLLLDLAQTCPSLLHVDSGFQPQFHTSTLASSCFEQVERLLLPRRIQCAAQQCKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SIS1</accession>
    <name>A0A088SIS1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_340810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702507.1">
        <property type="nucleotide sequence ID" value="XM_010704205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SIS1"/>
    <dbReference type="GeneID" id="22578585"/>
    <dbReference type="KEGG" id="lpan:LPMP_340810"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340013500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_340810"/>
    <dbReference type="eggNOG" id="ENOG502S3FF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="263350at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="520" mass="58531" checksum="C442E0CEE6DA4BE2" modified="2014-11-26" version="1">MMAAPATTSLDKVRAQLTALQNQNRISAEEAKRAAEQRQWEKLVKEQKEQEWVRAGIGLTHRKERDDSLTKLIQKEYSRLNKPNDAFRVGKEVVEGVAQRSFLLQERRFRDADEVLRKNGNSTDTQRYMILAFSSSPEQRIHLVEVLKRMQAQWAAECKRLTSACGPTQSSSNDNISGAVEVGSVTASQLAWLTVLEGLSEEDIHALWEAGILDAETLLSLFSDLSLEAPLPTESNVGVERTQNDDGQDTSDQYAPADLLLDEKIRYVQQLHCLQEITNTIRETELGDVPPIDLAPTIVKTRRRQFDNITEGELRQLEQYEESAVMNLSLKEPSPSAGASHAVKDEACNVGVPAVMLDRALFPSNRFLNAVAQKDAALRRSLERMERIKRETLLDPVFQEAVRFAHAVEEASVAPHLRGWSNSDGDDGKISSEKKCTPLRATRRIVSKHDKRVARSRQLRGPMALSPYSPEVIPYFYNDMRSIVPPRGAFNLPDPALTKAERAALRGRRRRARKGVRYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SLZ6</accession>
    <name>A0A088SLZ6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">U1A small nuclear ribonucleoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_357200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703647.1">
        <property type="nucleotide sequence ID" value="XM_010705345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SLZ6"/>
    <dbReference type="GeneID" id="22579748"/>
    <dbReference type="KEGG" id="lpan:LPMP_357200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350081800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_357200"/>
    <dbReference type="eggNOG" id="ENOG502SJKX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266020at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO02847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="164" mass="18147" checksum="6E4C1277AC0F4ECE" modified="2014-11-26" version="1">MEFIEVTNVAFPVGLEHTRRTLLRLFERVQSVEDIVVDVRQSRAMISFTESSAAQEALVLLDGFPLFGRALCLHVSPPPASPIRGYIVATKPSKYLLVRNTPYLTVVVKLKHIAGVVAITSAGVNSCFVVAESVEDTILLKEVLLSHPSRWGTEVFVSYLRKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4R2</accession>
    <name>A0AC62A4R2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ESAG-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3420300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="XUY36794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="648" mass="73470" checksum="1B69F30F5D0BB356" modified="2026-01-28" version="1">MAQTFHRGVAHSHRWRLSRSWRRCAGLFNRRAVPLVSAFAVVLLVTAAVLLTPRRYAQVPDGSDLVIPYRSKAAVYRQNAAFVAPFPRGGGIGVANTSTETVPAAVHSRSCRQEALEAEIETYLASHGIRRERRLRVRFQIVSNVVDWNLCTTLGSAALAGFSIPVTGFNATYSHVRRFESYLKFVEREELHDEDIVVTMDSDVYWTGADFLPFLGKFARFSPEKESDLDVAAVRAWEDYGEKKAPLYMQRLQAEMYNGTAGLKRPLLQMPPVVYNTEVPCWWGQNSEGFVQCPLGFATLERMIEVARNHASTIDVHKAASYAKVSAKTLRSELKKSFTGKQQWMVDDMLGTPNAASPYTTQAKRSRDDPLFYNVTVVSKSNPTVPLNAGMHVSRVWALRRLAKALATYTATETPVAEGEDHHTSKWWCDQGVLGQMYVRGRLYEVEHNLLAGPPLSRRTPPVPYDDRYGPPGLIGLDRRSEMAVVALSMLYSKTLFHSSKYLEEQFPGSNRWWIWNKAELLLGKNEPQGHSLKHLQTTRGGALVTPPLLWRSATAEDRSRGFQNEAEEDPDVVRIPFIHYAGPFKLKWFANQRHYYSWMVAARHDSRARESVTNALRKELVELWFNEERVFVNFTLMCKDPTLLSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4S1</accession>
    <name>A0AC62A4S1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">60S ribosomal protein L5, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3420245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="XUY36788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="305" mass="33978" checksum="53D9B3392DB961EC" modified="2026-01-28" version="1">MPFVKVVKNKAYFKRFQVKYRRRREGKTDYHARRQMVLQDKTKFGSPKYRLVVRTTNKDIIAQIVQAKIAGDEVLMAAYAHELPAFGIEHGLTNYAAAYATGLLLARRTLAKLGIADKFQGAKEADGSYSAVRTKKDDQGDDEARFPFKAILDVGLARTTTGARVFGVLKGAVDGGISVPHRPNRFPGYSKEKSALDAKVHRDRIFGKHVAEYLKQVKEEASSNPDEKCVQFSKYMEAKVAPESIECMYKKAHAAIRADPSKSLPKKAKKEGAKHKSYKTKKMSGAEKRAAAKAKVAAIRERLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A517</accession>
    <name>A0AC62A517_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NADH-dependent fumarate reductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3420130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="XUY36775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="543" mass="57545" checksum="4BC5586EA8412D02" modified="2026-01-28" version="1">MVSGTHAARLVLKKGHAKPAAPGRGRPRFPGRWRGMMATARGAQRLASDEAGVPHAKPRVLRHAGRFLLRGAPGECAARSRKNGSAWGTAVQKAAGVHDSGELFEKDTFASGKGGSCQPELVRTLSDHSAEAIEWLSSFGIPLTALTQLGGASRKRCHRAPDNPDGTPLPIGFTIVRALENYIRTNLSDIVRIETNARLISLMHSKEDDAVVVQGITYATQTASGEGKIRKLQARAVILATGGFSNDHTANSLLQQYAPQLSSFPTTNGVWATGDGVKAARELGVKLVDMDKVQLHPTGLLDPKDPSNRTKYLGPEALRGSGGVLLNKNGERFVNELDLRSVVSQAIIEQNNVYPGSGGSKFAYCVLNEAAAKLFGKNFLGFYWHRLGLFEKVEDVAGLAKLIGCPEENVTATLKEYKELSSKKLHACPLTNKNVFPCTLGTEGPYYVAFVTPSIHYTMGGCLISPSAEMQTIDDTGVTPVRRPILGLFGAGEVTGGVHGGNRLGGNSLLECVVFGRIAGARAAAILQEGGAGLPLQGGGQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A530</accession>
    <name>A0AC62A530_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Heat shock protein 70, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3020120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="XUY36962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="659" mass="71525" checksum="2AB403526B56502D" modified="2026-01-28" version="1">MFARRVCGGAAVSAARLVRCESQKVTGDVIGVDLGTTYSCVATMDGDKARVLENSEGFRTTPSVVAFKGSEKLVGLAAKRQAITNPQSTFYAVKRLIGRRFEDEHIQRDIKNVPYKIVRAGNGDAWVQDGNGKQYSPSQVGAFVLEKMKETAQNFLGHTVSNAVVTCPAYFNDAQRQATKDAGTIAGLNVIRVVNEPTAAALAYGMDKTKDSLIAVYDLGGGTFDISVLEIAGGVFEVKATNGDTHLGGEDFDLALSDYILEEFRKTSGIDLSKERMALQRVREAAEKAKCELSSAMETEVNLPFITANADGAQHIQMHISRSKFEGITTRLIERSIAPCKQCIKDAGVELKEINDVVLVGGMTRMPKVVEEVKRFFQKEPFRGVNPDEAVALGAATLGGVLRGDVKGLVLLDVTPLSLGIETLGGVFTRMIPKNTTIPTKKSQTFSTAADNQTQVGIKVFQGEREMAADNQMMGQFDLVGIPPAPRGVPQVEVTFDIDANGICHVTAKDKATGKTQNITITAHGGLSKEQIEQMVRDSEQHAEADRVKRELVEARNNAETQLTTAERQLGEWKYVSDAEKENVKTHVAELRKAMENPNVAKEDLAAATDKLQKAVMECGRTEYQQAAAANSGSSSNSGEQQQQQQGDQQQQQQNSEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A576</accession>
    <name>A0AC62A576_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Eukaryotic initiation factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2520020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="XUY36904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="166" mass="17812" checksum="AAD7DA0BA8339A17" modified="2026-01-28" version="1">MSDEDHDFSHQGGGDNASKTYPLAAGALKKGGYVCINGRPCKVIDLSVSKTGKHGHAKVSIVATDIFTGNRLEDQAPSTHNVEVPFVKTYTYSVLDIQANEDPSLPAHLSLMDDEGESREDLDMPPDPALATQIKEQFDSGKDVLVVVVSAMGTEQVLQTKNAAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5E3</accession>
    <name>A0AC62A5E3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3520140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="XUY36846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="641" mass="71864" checksum="4C154660689DF93F" modified="2026-01-28" version="1">MKSRRFQANPDEAVDPLPFDYTLLSHLYVHSDGTDVIDFSGLAVGKESHCRVHSLLKNRSFVPGMMEAEPEAVGSYLHLRVDEDGGSTLDGSGDYKIHGARRPDPPRGVSAPASNLVRIEDRAEHWWFVCQAAEDTALYARLFNGTEDLLRYLKQHKLHLPTGLNSESGTANEAWAPPKPHHDSSNSVSDTTEPVLPLAKWLDIQVDRSNPLSVERVTQLLNHLPISQETKESCLYLSTVDSIDINSQNTGSVSDSMSGYVFLNLLCTPVVENGGRRATTSTATTAREAGNTGSTSNQKGFLHRLCGFKFDFLRTDKRRTTKRLKIPRRAAAHVSPHGIPPTTQSVMEMRFEAARINAPRSSVPDPVAVAVIVFADWMITIHEKPFAEMDDMLRMLQLHCSPPEVTTSHLGYTARLSSSMRRRFTAPFAMSMLLQIVVGHHLDSITLAQAVDELGDCVFDVREKQEDQDAVLQHITAVRRCFGECGTDTVRREVLFASLLQPIFADRFFVADPAIRHELENAQAHLWHFQREISDCRDTLALSNWHHNVAIQWLLLRRGNRALRMALLLTEMTNIMQPIVILQTLYSMNVPLPFEAEGNPPQTTLAPFFFLAAIFLIYCTFTIGAIRHIIVRKSFQTRLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5I4</accession>
    <name>A0AC62A5I4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2920080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="XUY36943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="297" mass="31535" checksum="97B738E6226232F3" modified="2026-01-28" version="1">MVDCSSDRQYLARCAYGDSEKSIEVHGAKMETFNVDIRKNGAMRNRAMVLSSLTGLCAAAGVAAVAVGAPQILVGLQSVRCLPCMILCTVAGGVCLAYVSTSSFSFERTIYDLELQREMWEIDNHLSGELQEMLAIYKGQGLTEEEALIVTRIFARQKTVFANLMMVEELGYSRLEPPTTSEAAMNVGGPAIMGFMIGVATPLLCLAGALRAFSCGQGDSVGSNCRGAVAGSSVLATRTKLLGAGIFCTCNAVLSYVQTEVFFGAYAHMPALIHTTVSNAIGIGSVFGLCYLAARWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5N6</accession>
    <name>A0AC62A5N6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histone H3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1620460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="XUY37057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="66" mass="7238" checksum="D87F239EB5F19D1A" modified="2026-01-28" version="1">MPCARCRACRRRGGPALPEQRDPGDPGGVRCVADGCHEPGQHPREACVTVRPKDVQLAVRLRGERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5S4</accession>
    <name>A0AC62A5S4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histone H3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1620220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="XUY37033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="66" mass="7238" checksum="D87F239EB5F19D1A" modified="2026-01-28" version="1">MPCARCRACRRRGGPALPEQRDPGDPGGVRCVADGCHEPGQHPREACVTVRPKDVQLAVRLRGERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A627</accession>
    <name>A0AC62A627_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amastin-like surface protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2020600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="192" mass="21604" checksum="BD3955FDF87A05E1" modified="2026-01-28" version="1">MEWNIALLVYVVLQFIAFLFVLVATPLDMLRFKPNFRRIEGCVTLWGHKTVCNSMFYDRNLYEAWGICPSRLMRFRVADAFAIISIVVYGAAFILGVIMLFCCSCLRFVCVLLNIVGAVTVCVVWAAMVVTFFKDDDEDCPALQGFAQYGVGFALLIIAWVLDVINIIFLVLSMTTAALSANGQVEQEERKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHP8</accession>
    <name>A0A088RHP8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arginine N-methyltransferase, putative</fullName>
            <ecNumber evidence="7">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_030550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CP009372">
        <property type="protein sequence ID" value="AIN95290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700998.1">
        <property type="nucleotide sequence ID" value="XM_010702696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHP8"/>
    <dbReference type="GeneID" id="22571921"/>
    <dbReference type="KEGG" id="lpan:LPMP_030550"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000023800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_030550"/>
    <dbReference type="eggNOG" id="KOG1499">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000434">
        <property type="entry name" value="Arginine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF118">
        <property type="entry name" value="N-METHYLTRANSFERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="5">
        <location>
            <begin position="78"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="6">
        <location>
            <begin position="186"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN95290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="405" mass="44365" checksum="9F0589EFC3F50EDD" modified="2014-11-26" version="1">MPSRKSTHMTASAKRSETHSANADRVVLTESLLATEAEKNATSKSLYGDSAARISSNISTIHDHQRLRAYEVIFRNVRGKTLLHLGCGMGLYSMLAARGMAKMVIGIDSSAIVDAARVVAEQNGLKNIQFIRGRLCEALHQLPSDMKFDYVLCEWMGPLLLNERVLTDALYARDHLLTESGALCPNRASLHVVAVSDYAFRLDTEDFWSNVYGFQMEPMKELVRQEVEMCAIPGSNIVSAPCLAHTIHMDTLEGLTAEETATYEAQANQAAAIRDNEEENPVEHCWVPAAVAQKGYEAAFTLSIARSATVHYLTFYLDAAFTSKTNPGANFVLAVRPGGQNNWTEVSVGLREPLPVNAGEKIQGTVRVYTPADKGGKVTVVEVTAKTAGQVATIETFGTYYYQSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIB2</accession>
    <name>A0A088RIB2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Dipeptidyl peptidase 3</fullName>
            <ecNumber evidence="4 15">3.4.14.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 15">Dipeptidyl aminopeptidase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 15">Dipeptidyl peptidase III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LPMP_050940</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity. Also acts on dipeptidyl 2-naphthylamides.</text>
            <dbReference type="EC" id="3.4.14.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 17">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15 17">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase M49 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.4" evidence="4 15"/>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="AIN95535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703857.1">
        <property type="nucleotide sequence ID" value="XM_010705555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIB2"/>
    <dbReference type="GeneID" id="22572172"/>
    <dbReference type="KEGG" id="lpan:LPMP_050940"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_050014300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_050940"/>
    <dbReference type="eggNOG" id="KOG3675">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4694525at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000001">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000002">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005317">
        <property type="entry name" value="Dipeptidyl-peptase3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039461">
        <property type="entry name" value="Peptidase_M49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422:SF11">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE III-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03571">
        <property type="entry name" value="Peptidase_M49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007828">
        <property type="entry name" value="Dipeptidyl-peptidase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 15 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 15 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15 17" id="KW-0862">Zinc</keyword>
    <feature type="active site" evidence="16">
        <location>
            <position position="429"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="485"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR007828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR007828-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR007828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AIN95535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="679" mass="76022" checksum="9445EC2A8484425B" modified="2014-11-26" version="1">MSHNALYVTPRAVPYCTLAIANAFKDLTPKQRHYAHHMMVAGWCGTPVVAEQLSPESLPLLRLFFQVLSAQPLDTFKSNSTNAGVDPNEVSQFLEYFAMVYSNMGNYTSFGDTKFIPSIAKETFAKIVTSAEGSPAVDTQLLDAIYDLEDGKLTLDFPPRGLTRYYSPNITREDAVVANDFLALKRIDGVNTRVFKAEDGTLVIRVAAATEKTVPAVEFNGRTIAMYYGDYKEEMARVVAELRKARPYAENETQVRMLDHYIEHFQYGDVDAHKESQKEWVKDVGPTVETNIGFIESYRDPSGVRAEWEGFVAVVNKEQSKMYGALVEQGEKFIAHLPWGKAFEKDVLPNPDFTSLDVLGFASSGIPAGINIPNYDDIRQTVGFKNVFLSNVVNALTFKEKLDYITEADWELYKTSILAATSVNVGIHELLGHGTGKLLLENSDGTFNFDKNTVDPISGQPVATWYKPGDTYSSVFGGIGSSYEECRAEAVSLYLCLLPDLLEIFKLKTAKEQQDAIYICWLNMVRAGLVGLEFYTPEKQQWRQAHMRARFCILQALVRAPNSIVHISEDAKEGLLITLDRERISTDGRQAIGDLLVNLNVNKATANVKRGSAYYEGMTVVNDKYVCYRDIIMACRKPRKQYVQPHTFISGETVEVREFAGSVEGVVDSFVTRHREIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RID4</accession>
    <name>A0A088RID4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_070310</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="CP009376">
        <property type="protein sequence ID" value="AIN95717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704039.1">
        <property type="nucleotide sequence ID" value="XM_010705737.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22572366"/>
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            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
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        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
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                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
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        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22977">
        <property type="entry name" value="WHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="681"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="940"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="209"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="246"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN96037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1159" mass="127714" checksum="8514112F2B6E9C62" modified="2014-11-26" version="1">MLQRLCEYGALQVPEFDSDSAYLAAKDVLVYLKHYGYLVSAMTLSAAILRNVELVGLDFRQHCVPCMNAITQLVDYLINAQLRKMQLPPRVVRLSERLRLSAKAARTLEYLLVCHCGRYAPGNIADPLRPASIAYHNELTPQELLSILSESGVLWKQGLIFSDIKMRTTFMECKYALPMETIAALSGDRLSEEQLIKLERTALLEVLSEEQHAKTTNTAAASPTPRTEKHVGGRSSVSPSPKHDDEEGDVIDEEDDNTDAESAITPDEEALENVVDEIDPSVLTSKDQDRLHEAVSHDLRNALSSSTATPFDGCTTVAAAAKNAAVAETEEAVKDGERSKEELVIVTPSTTPTALPASSVAEITQPPEGVGEATTATSAPRKARLVLADINPLAQRYRNTGTGVGTAVAATSSSPSTTAHTDSSMRGVPYESDIEYMDAAFRILANMIRIRYAEGDMKDEEDSYTPKSKVEASIRELKGKVRVAAAVHESRLQATLATRAFTPRVEQLAQRLQLTEMEKQIMLFMVGNVISHDMLVAVNGRYVMRDGQRLITVGYMLFVLCESLEERVVARRAFYQSSPLVSNGVLSLTLDSVGRSCFNTDLMDYLVDIDRKIVDDVMGITAETAEMVPGSQLYFPEVELANVMLPTATMDRVLSTIEHYSLFEQCKKGSGFGDGLGTSKGGLVMLFHGPSGTGKTMLANAVAHHLRKKILLVSVSQFRSSTKSESDALRFLFREAKLSDAILFFDECESLFEDRTSNGTVTALLSEFERYEGLIILATNRAQNFDEAMNRRVSLMMEFRPPDHQLRLRIWKSHIPRQLAVNADVCLEKLALNYELSGGLIRNAVLAALSKAVAREKCAAPELTMSDLDEGARLQLRGFFLAAELPEGMSEFYLTPKRTLAELVVESSLTKKLEGIASSTKSRNTLYTDWGFSEDANDDCGTLYLFQGVSGTGKSLAAEAIAYECGATIRLCNVAELLLREEMRVHAVFEEGRRLGAIIVFDEAQVLFNESPKSLQLSQLIQYHARRYPRPVIVIATTASRNGGGGRHLFSTTSINSHSSCMLFQSELIFALPSRPLREQLWRKAFPERVPTASDVDYGRLSTTSISPKLIRTIAFNVCCTAALLPVSERVVTMAMIEAEMERTMTRERSAVSTSAMFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJ77</accession>
    <name>A0A088RJ77_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ama1 protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_010690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009370">
        <property type="protein sequence ID" value="AIN95169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696711.1">
        <property type="nucleotide sequence ID" value="XM_010698409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJ77"/>
    <dbReference type="GeneID" id="22571798"/>
    <dbReference type="KEGG" id="lpan:LPMP_010690"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_010010800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_010690"/>
    <dbReference type="eggNOG" id="ENOG502SM6E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="257806at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="234" mass="25299" checksum="AAA47CEED1DF62D8" modified="2014-11-26" version="1">MSKSDLAKDSQAPLPAMVLRFGDDVGDASYPEAALVVEGIAAPCKAETKKVNTDRDDNASSTECAPPHAQHCHQPPRRDFRSGLFDCHESWAVCLDACLCTYCVASAHHNFLMNDTAGVYFPACCGLLCVDAGLSALSSCLPSSLYLHTYLMRSAIRQRYGLHSADGRVDSDEHDSGSYRVCSTESLLDLLAVSLCLTCVIAQHQREIMHQGDWCGGVFSNRSSLQAPATVHTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJD0</accession>
    <name>A0A088RJD0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_090980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN96013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704335.1">
        <property type="nucleotide sequence ID" value="XM_010706033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJD0"/>
    <dbReference type="GeneID" id="22572668"/>
    <dbReference type="KEGG" id="lpan:LPMP_090980"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090014300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_090980"/>
    <dbReference type="eggNOG" id="ENOG502SMQ6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267967at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="795"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="887"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1006"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1061"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="574"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="799"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="817"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="840"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="948"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1061"/>
            <end position="1073"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1090" mass="113543" checksum="775150738EC31AFA" modified="2014-11-26" version="1">MSSSAAENSNVEEEEEAKSMTTVATVTASANTRSTYGSKEWKVRLMNWRGVGGSTQSNTGGSDGSGTSEVAAAASEVTTEKGEALDQKSAEGSKSSATAPAENDAAAAAKTNSATAHASPARPMNIWLRRALERQAESAIAAEIHDAKQASVGAVVESVAGVALGAVAAAAAKVAASEPEGNGAVAFEKRLAAQTRFAELMREHREGPRQPSAQPPVKATKVVKKPKVTEPTSPVVTPTAEEKSSMSISNKKRAAESAGQAHAAPDTEPGTLSPSEAKTGKAEGGPTQPTSMAEVDSSAAPFAAAAVHQATVRKRKKATSSASAKRTQGASVDASTATTPTHVTTVKGKASLEELRARRNRTTAGGSASRRDDPNSSEGSTGMAGSSNAGNAVSGHSQQDEYNDCALDAISRLLLRYCLGDSTAPVTPSAATAADSADVSSSAEPAVALTTESSPVPTQMTTELEFFNELMELCENDSLTPASLELLRELFQHVRVLPRSSSVSDAGKRGESADASACTVQDGEAAMEETDVEAYREAIRRREYVQQVIMVLLNRLKHMKMQEQRERQQSDGDTAAAATSAASAPLPAPAGKNQRSNSQCAPMPPLSPQHKSGMIYPGGQTMASAAPWPSMAEMAGAYPDEVTAAFTSAMMTYGYPNPYAHLTVFSQHQPVAPPVGWPPLLHAPIPGARHGRHDHHDSNSNVAARLVASPFPGAFPIIPPPATADTFAGAEDREMQELLRMIRAQLTQPASMKLSGMSTADSRVESSVNLSGAAPVEVSQAERAVLRHVQMDFKKHLEQQQQQQQAAVVASPAEGSPAPPMATLTPPPEMDTTQPRRMHATPGTAAGTSASVTGAATGTAMGTTAASHVGSENSQHHHTLLGHQASGLEETGEAAGESPSARSTTAPAQEEEGIVTDEATPAKSRGTTLNLNAKPFVPSGARGGNGSTTTTIIIKPTATPDSTPTKTTFNYYAKPFLPSVRVNLPMPTLPQKRAQMNVAAPAFIPKQQQQQAPSRTDAPAIPPPPPGCVTDPWASYEMFARWRDMMEAYYQNVFAQQNAATTKTGTAPPSATATGGGPAPPIMMTSPHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJD6</accession>
    <name>A0A088RJD6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LEM3/CDC50 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_091030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC50/LEM3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN96018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704340.1">
        <property type="nucleotide sequence ID" value="XM_010706038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJD6"/>
    <dbReference type="GeneID" id="22572673"/>
    <dbReference type="KEGG" id="lpan:LPMP_091030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090015800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_091030"/>
    <dbReference type="eggNOG" id="KOG2952">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="340608at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005045">
        <property type="entry name" value="CDC50/LEM3_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926:SF73">
        <property type="entry name" value="LEM3 (LIGAND-EFFECT MODULATOR 3) FAMILY _ CDC50 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03381">
        <property type="entry name" value="CDC50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="499"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="590"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="590"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN96018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="613" mass="68300" checksum="996609EADCC3E71C" modified="2014-11-26" version="1">MRQRSKPATAVPPPASDGGPEDSGGKPVFSPAGTTPWSPQRDASPLSTSSEVLSSADSSSACESSPRSSSSCSDGDDEQRRVGNRGGVTGAANAAAASADYSKSRSARAKRWLKKNLIPEFVHEYGRTVYGGNPLSQQTLPGVFNYPSPFILVPIFYVLMVPFLIVGGAVLVKGRQQHIIEQEYSHIHQYQYVPSNTSVNINQGILQFTADGVTHVQGTRTWLEINISRGILAPVYMYYKISNMHQNHRDFHRGRSNSQLRGKSTIDKTYTCQPYTYPGFRNNKGETPITITDATGRQVTRPARYFTYNPCGIAPWSKFNDTFVLYRKLTPAEVLQASISGVPVLHGGVDGTTPVELICNGTDFGLKGEPLDGSVAVNRCSKMGISWKADRNIRFHNMTLREDWWSLYYPYPTTNEYLRNGWYLDEPGHSLPDPSDYDLQVWMRASFTSNFRKLYRIIDMPLYPGTYLVDISEFYDVVSFRGRKSVVLQHTNWIGGPNIGLGVIFILMGCLSFILGVTFTVECLLQLNGVNRYERLDEPKRSWYVFPPNEPEFASYYQLRLRRHIPMAQLQSLRKAVAVLEDLVHASETAPLTQQQSNSDTEVSGAGGNGHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJE5</accession>
    <name>A0A088RJE5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_100330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696755.1">
        <property type="nucleotide sequence ID" value="XM_010698453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJE5"/>
    <dbReference type="GeneID" id="22572769"/>
    <dbReference type="KEGG" id="lpan:LPMP_100330"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100008600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_100330"/>
    <dbReference type="eggNOG" id="ENOG502SKS7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="263705at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="474" mass="49446" checksum="A3623CC6C3F83F02" modified="2014-11-26" version="1">MPAAITVHPLVLLSVVDHVTRVGLQHQQQLQSQKRGNTPDVAAASPPAPAFLSTAGLLMGTTKASGPSDASTCGADGSSRVLTTTLSASFELPLRLQPTDGVAVNVAASGDATFLKRVLSDDTDWQGVQKHREQLSAVMPELDVVGCYVVCAGSRWTSTTHRRGGDDGDGFPLSIESAVKKAKGEAIGDVGGIVAIANCVQQLLRSTALLPPTATGFVLLVVYDKEVTSATSETGTAAPSLQQSPVAVRLPFDCFYVSATTVSDALSSEEVEVGPADIEWIALANETVMPPRRQGSTTISSAAQAPAARETTNTRTPSMASPQNFSAAEELVGSLRLVMRLLAKMTESTLSTTATVPGDVELLRTVATCLRNVPDSRPSPSPGDSTAPCALQTVEVLSAVLALEVQCALHMRSLSKAQQQLLSSNRPAMEALHSTTRSPKAANAPPPDAKVGRPTHGRDKRSGVPTAALGHVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJT1</accession>
    <name>A0A088RJT1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_091520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN96065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704387.1">
        <property type="nucleotide sequence ID" value="XM_010706085.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22572722"/>
    <dbReference type="KEGG" id="lpan:LPMP_091520"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090020600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_091520"/>
    <dbReference type="eggNOG" id="ENOG502RW9F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="243088at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1637" mass="185105" checksum="5AC57BB9A1471746" modified="2014-11-26" version="1">MVLLFSVENPTGKDGGKEDGKGEVPYAWSTFKDRIAVIYDDRKGVQPSEEEIEWQLQVAQFPVTPHFFVTPFDGVMDGNDEQESKALQLVFEDIMHCVQRRENVTVIHRGVNAEAHLETILISFLQAVRSSAEYGMQVVADEIAKEKQMQRLLQMNANSGDADATEARGTKAHERDTTGQGGGGVQLSKALRRKIAKLRQEYHYPHPADRQVAARSRYGLISAAHNDLLYPPRNDSSLLRPQAFIAYPPVSRATRTSRAASLAAAKSTRSHTILFNQMQRRNTAKMLEELREQEAVGDCEPIPGNGWGDKVTFYTFDGASSVMALPGIPNLDEVIRELAVDFWVRTDLKPADGKRVLMQMMEGQREDVGQLFQLSLNWYEDMPDSLRVVIRDSANRVLEAVGSVAKVGLTDGTKFHHVMLRVHSLEEGQLSCEVDGRPINIQLIQQEHPVAFNPWSHRLFVGGYLDEVNSPALVFRGVIAELRFWSGVFPSHPIVRWPLFAVEGGMLQEMTRTIPADHHETLLNLHAVEESPPRSAPSFDGNLVVNVGTLPLFGQLMHNWRMELSFRTDVSSRMMTLVGVTDRNFKMQEFGIVLNSEPVITKERLRYHELHTTFYIVDAFGACCSALLRGTERQNLMDGEWHKLVWRCIDSETNNFSVKVDDVLQDLLFVSREGPTRFVIYDNWIAVGGHNVRNWKIQRPFIGQIGHFFLSLQRCPYVTLAMDEGPGAYVLQDRSHHNNHGLLINSTTNVVRRNDVVWTQGPADKSDDVDNAAWPDMRIFKNNNVSVAAVVFTCAFGERSVAHETLYDVLSGKFHEVENAPHILTERTEAQWKSWYGLPAECYHALDSVARLEESINVVLRAEAPRGHLLVTVHIGDCFASVLHIREPELPADAVYDCNMLKWHYPYMVEGMQGRRELMLNRMIEGVERVLLSDTLKPYVTAKLGPLNSGSRSVLTDDIIRSLQNIGWPWFLPVVLHTHLLNAEFGSTLHLIQRVRPHMSANEAAAVSFVSKKLTDGVRENASLMIQRNWRVRLAKREAARRSELRSLNDRKVEEIRALRMNATVKMKGSLCALLITLHHPQCPGVPAIDSDTGPLQDALRQQGYEVTTLEDPDMATMLRAVSQTDTTKSNFIYVSGYGGALNLRQPPVFGFESLAVYVEEEAQRATLDCDESGTFRQLMVQMKAEKAMVPVKKSKKKAKKAAAAARPRKTAEEAELQQRQLEGLLFSYRQEMEMEELSYRDSLVHEYESMNQLLSRQLRHVTAVTREYEERYKSKGPEGDAQNYVYTGKSRMIESFATTVVDMEDVIRAALHWQDPPPGLQCVVAVDLQPVMPYSCGVACLASSTGNTFRVPYRPQQRELLSPILVKAFNGQLPKISATSKYAVLSGGIETAVNQRDWKSFASYVVRKLQPYCPPERFRMLCGELDRHLPFVAELVPVRDIVMDAEARDRRRRERDTQKVKAQVSFGVGSAKIQSDMFSLFRDFLEGVTVSELAFVNTIRILFTQQNKGIDGIQVEEVIGALEKCRPAVCSMAFEVRVTAAGVEVQFKVSEVGDKLLLSQWLNVVSLRSLTWQFHQRPLFGMGRLEVDYIEYLYDAKFACSASRYWQLCKQFHAFPVPKPYVRFVQARVLMSSDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJV5</accession>
    <name>A0A088RJV5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_100880</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696811.1">
        <property type="nucleotide sequence ID" value="XM_010698509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJV5"/>
    <dbReference type="GeneID" id="22572825"/>
    <dbReference type="KEGG" id="lpan:LPMP_100880"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100015300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_100880"/>
    <dbReference type="eggNOG" id="KOG1465">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269919at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10470:FF:000027">
        <property type="entry name" value="Putative translation initiation factor eif-2b beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051855">
        <property type="entry name" value="eIF2B_beta_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="155"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN96158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="533" mass="57802" checksum="196265E48FAF0AFC" modified="2014-11-26" version="1">MLGNVPEEPEKLVRQVSDLAEAFITNLKRGKLAAARSDEESLSTAAAVEMADMMSTIVRLFQDAEKDPHSITIQLLKAGYPAAEVASMQVSRLLILVARTGDTLLRAQFATLFLMNVTRRVLSIVRESAANSKATDAELEDEAKSILNDLASDNEEVVVESPADTRSSSSNRSGRDDSAELSNPSLHGKGMKPALRKDLLASQPLPRIGFSVRFTGASIGTEEASGSHVRQLQQHSASVASDFGGPLLQRTSSIVAREIPGRQLLKRAPSRREQVLVEGGGEIEFPVRMENFYQDALDAIDEFKREIEGMTGELCRRSPRQLHSSDTIITLGCSHTIRRYLLEAAHAGHHFKVFILEGAPLPAEGTQEFAEALCSRGIAAQLLPDSSAYVVMSMCTKVLVGAENVLANGGMLTAIGTHVLCVAARHFAVPVLVATTTLKMSPYYPSDQLCTRLVRIARSGAQEMPWSTYGSPEDVWPSPFGVAVSDSGRGLTIHAPVTEYVPPELITLFVTNDSELLPSQIHRIVRANYSDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RK16</accession>
    <name>A0A088RK16_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial glycoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_050770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="AIN95519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703841.1">
        <property type="nucleotide sequence ID" value="XM_010705539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RK16"/>
    <dbReference type="GeneID" id="22572155"/>
    <dbReference type="KEGG" id="lpan:LPMP_050770"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_050012400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_050770"/>
    <dbReference type="eggNOG" id="ENOG502QZ8X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="278212at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.280.10:FF:000017">
        <property type="entry name" value="Mitochondrial_glycoprotein_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.280.10">
        <property type="entry name" value="Mitochondrial glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003428">
        <property type="entry name" value="MAM33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036561">
        <property type="entry name" value="MAM33_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826">
        <property type="entry name" value="COMPLEMENT COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826:SF9">
        <property type="entry name" value="MITOCHONDRIAL GLYCOPROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02330">
        <property type="entry name" value="MAM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54529">
        <property type="entry name" value="Mitochondrial glycoprotein MAM33-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="340" mass="37262" checksum="F014950511F9F8B4" modified="2014-11-26" version="1">MARAYATTTPPLEGSHNDPADEGVHRMNDGSVGAAAAHLQHAPTLRSALPPSAVELPEESFLKCIDKEIFDEKVRLDKEDGPPPVPMGWTMHHTEGTSFIYGRRLWVPPPSSSSSPRPRSRDAEAQGNDVSGSSTQENRDGEQQREVRAAPRAVERHFLRIQLTARDASLDPECDVRGEHFPFSFFVQRVLSEEGDGGSGAGVTDSSSGEQGTTASSEDTLHGDVSEEHTFYHNSIEARCDVVDGELIVDNVVYHGPPPHTSNSPSSSGVPQPRYTNPFGGYPGPNLDEAEEEVLDGIQSWLAERGVDDQLGEFVGQYSIWVEQAEYERWLQQLRDYVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKC9</accession>
    <name>A0A088RKC9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MINDY4 N-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_120650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009381">
        <property type="protein sequence ID" value="AIN96393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697046.1">
        <property type="nucleotide sequence ID" value="XM_010698744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKC9"/>
    <dbReference type="GeneID" id="22573071"/>
    <dbReference type="KEGG" id="lpan:LPMP_120650"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_120011100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_120650"/>
    <dbReference type="eggNOG" id="ENOG502S4YU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10263628at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059022">
        <property type="entry name" value="MINDY4_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26038">
        <property type="entry name" value="Dimer_MINDY4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MINDY4 N-terminal dimerisation" evidence="2">
        <location>
            <begin position="26"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="346"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="530"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="620" mass="64995" checksum="C839145D7C7C1247" modified="2014-11-26" version="1">MTQPPSASEKEKTARLVESLSRHEQVKLLAEALLREYMHRRGLRETLRTFDAENPRDERTISSRALMRQLLNIPVEGRPSRLQLTASSLAKPQAPTFMEELCSYRLTKRSYRIPDGKQSGKPHCSQEEEEDPSDVELRALHASADAQRAAKALCEQKQREYEELLAAEEAYQQRKEMHKDKKKRKHKGARRHRDKQRVRGDADSSDDGAESESGNSDGSENEEGSALSIGFSHTSRKAKSVSSSKCRMPDESSGGAKEAAVAVGAHWQPPGSAARAGANHNTADDGVSRHSAKRIFGRTADLELDSDDHEVSSDNEKVGLFGLSGASQQVLMARIRAGSEHWPTQAHGGATHAHASSTRNHNSGVSASGNSLSAAPAALSTVAGRDAGGREFGSLRSTRPVGRAAVDFDPNGAYESPSFSGSLSATVPSGVNGGVAALRMKTSPIPIPGLSADGAASGLSNTYSSGFSLARSAAKSASGILVRHRDAPPQRDRGAASDGPIHSYDRTAVPRSSALAGRSDGSNARTALRSSSPNASAMSESTSSGSCHTPSRSFANSMGGAGGSGGGGGSGLRHGIGFRTSSTSAEGTALASTSVTGAAALAAGAAKPSRKERCVKLLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKE5</accession>
    <name>A0A088RKE5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytoplasmic tRNA 2-thiolation protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_130680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697150.1">
        <property type="nucleotide sequence ID" value="XM_010698848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKE5"/>
    <dbReference type="GeneID" id="22573178"/>
    <dbReference type="KEGG" id="lpan:LPMP_130680"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130011100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_130680"/>
    <dbReference type="eggNOG" id="ENOG502S05M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25129at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019407">
        <property type="entry name" value="CTU2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882:SF14">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN96497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="676" mass="72619" checksum="EF31DBAC149FF300" modified="2014-11-26" version="1">MSQCFKCKQAIGTIVSRDGPTKLYCSNCFLTYCAGAVRENAFQECLVPSDTPLAVAVSGGPNSMMLLHEFGQLRYKAHDQIRRKQLAQQRQACAQGAQSCGIYASSSSATSTSLVSSLVLLPFHLCEDELVLPPLPPPQSSSPPSSSSLHECSGRHEAIEEVRSTMKEQFTKLRKYVQHQPPRWVYHTEVLSEYKSAKKKQNTLTAAMGTDVARAGGACVATPGLSVSSGGSSASPASSQQQQRHVEASGETAATDARLFDEAEMRLFHYSDFLSERYVSEVRHALHASKLSLSDREALYARVRQQTLCRAAQRVCREHRQREAAAAAAAGAGGMKHEEAIRRGETCCSEAQERFDEHASLHDTSWGGKSHVLLGNNAARCAIAALEALVTSASGEGVVHGAGFRGFTHEVVCLRPIRTMLPKETILYTRLHGIVCSYTPALCTCTATRSIHRTLEQFVLTMMASYRTMIFNVLNTVQRLGVHPAAVQELVSGEGSAAAGNSQLAGKTSRKALPGRTAQQNRDDGRLTALLHVHRDPRRLSLKEADRYNAIAMCCVCGCPASLAACHCGHRTDTAERQLALFALCPISEATPRASEVSSLTIDGAVSSETSVMPSCFVCYACRGLADSWSPSVFGSSSTTGNGESGDASSTATGVASRHDVITSTASVSQLCKLFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKU8</accession>
    <name>A0A088RKU8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_070990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009376">
        <property type="protein sequence ID" value="AIN95784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704106.1">
        <property type="nucleotide sequence ID" value="XM_010705804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKU8"/>
    <dbReference type="GeneID" id="22572434"/>
    <dbReference type="KEGG" id="lpan:LPMP_070990"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_070015200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_070990"/>
    <dbReference type="eggNOG" id="ENOG502QR99">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10258956at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035082">
        <property type="term" value="P:axoneme assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060294">
        <property type="term" value="P:cilium movement involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044458">
        <property type="term" value="P:motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055316">
        <property type="entry name" value="RSP9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22069">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22069:SF1">
        <property type="entry name" value="RADIAL SPOKE PROTEIN RSP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="338" mass="37112" checksum="9718B02540CBF66E" modified="2014-11-26" version="1">MSVANAAYLTLNGSCLTAGEQTALQCSLPLLSQRYRGTPMQLWGKVAGIKTHYWVVQAFPNGEFAPAVSFYSVDGGNTWAMLSALTEEQAALCEALRGPYQGVPSYEYRMRQDLPAETDEVAVTMPTPDDTVKKAEEDIAAARAAGGANSDDDDEEQSDEEEEEDEEQDGVAVPAPRKRTAKFRILSITEAMRLAHFVLLHDTDCRLAVRGMFVLQDGAAVGVRNSTFGGQPLHHAKKPSCYVKMACAGKEERNRVLYGPTYNPHTDYLMPITDDAPAGVWSVKYNATANVVSVRNLFYEGSLFWYRPGTLECGQIYCGSGERNFDVCFMLSTVAPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RL14</accession>
    <name>A0A088RL14_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_140990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697330.1">
        <property type="nucleotide sequence ID" value="XM_010699028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RL14"/>
    <dbReference type="GeneID" id="22573366"/>
    <dbReference type="KEGG" id="lpan:LPMP_140990"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140015300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_140990"/>
    <dbReference type="eggNOG" id="ENOG502RDKY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="238752at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="333" mass="37430" checksum="7CC8CDF3E606466C" modified="2014-11-26" version="1">MTEGRLETIHNLRPKNWDNRRHWTNWHHLYDCEEDHITRESAPFHDLRAGGQFQYEYSGGGPYAAPIEPHHVNDRSAGDRMDFALGRGTDMGGMGYLPLDTEPGRPVKPSKLPRQTAMFTRNCPLKRGLFSEYPHMLEDNGDTTGPSPRAGVMKAGGPCGYLGGAAEHIPDPYSDKPNRGRIWHFRTGPVKHDYPKWMPQGEPEKKPRKTYGPFRAGKPDHLHIGGDVEWIPDPYDKEPIRNNRHPFRTWHTRTKWSMPVLAPWSTGLATSEARKGAGLDLTENSLPSLKTYRKVNLTQTIGAEAALSSMSSKRRYDGTKSVSVRGGGGQGTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RL68</accession>
    <name>A0A088RL68_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiqitin hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_090230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN95939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704261.1">
        <property type="nucleotide sequence ID" value="XM_010705959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RL68"/>
    <dbReference type="GeneID" id="22572593"/>
    <dbReference type="KEGG" id="lpan:LPMP_090230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090007300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_090230"/>
    <dbReference type="eggNOG" id="KOG1870">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="73004at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF92">
        <property type="entry name" value="CARBOXYL-TERMINAL HYDROLASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="1">
        <location>
            <begin position="153"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="916" mass="101610" checksum="493971DAFC97A173" modified="2014-11-26" version="1">MSSTTSSRGQPRHELLKEEPMISFEVELDEAIELPCDVGTVAPTDAALSSLHWRKQTVTPVARTTPEDMTTQSGSSTASLRAAVCGNGMGLPNTTMTTGGVTSPVATSANTVATTYMAAAPSRKVTWKDTSASQRRAEAQASREDDFNPMVLCPLQNLGNTCYFNAGVQLLVNCPALVYAVRNSPFARRMQSHSAFNVYNVSVPVATVAAAATAKLYPKGGVATHALFQEFAALLARMEVGCSAGERAISPIRALDSLASVHPQFEGRSQQDASEMMTSLLTSLEEEGGQYVELAQLLQSFEEDAAALQQDAPAARIVTTVNPPFLGTGPSSPSEQHQRYYSEPYSVDEYSLSSRHPSRTDAILPGPRSAHFLAVLRLMEQVNRENEVLEQRVKHRQGKPYTGSFKPPRLHFNPLLDSFRGYTLSQVECHNCRAVSRVVSAFNGLMLDVPTAKQRRRYAMAHPNVPRRADWEEQLQHVKKPFRLSWWNPFSLCAAAWQHLKRLLQDPFPLPLWLDECLDIHFEPEMLRGCNKYRCETCGTTSEATKSETLLALPEYLLIHMKRFEVGRFFNSKKTDSVFFPASWRSLTEAQAAALLNERSETRSPLPEYLDLRRYLHSSVAPFAEPIPPCLLDTGTEPYQQQHASESRTRSPTSSIATTYTLDGIVNHHGGYDSGHYTVFLYKATEERQAWVYISDDEVVQAEDVVATDTEYVLLYRRQPLVQVAPESDEAEQLRRKACYYLSPSSSPYLTAYAAANVASPAISKSHSTTSASSYLTDSAAGGLPSATAVATAPWVYISRMWLQRVAFMHEPGPIVNRLCYCRPEDQGRVSMYQTIFPATVKVPAEVPHVHGPPVDWFYVPITEKDYAIFYNAFGGNVAVTANEYETLRAMQEKFCADIDAAERQRSGAARRASQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLG4</accession>
    <name>A0A088RLG4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_150290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697406.1">
        <property type="nucleotide sequence ID" value="XM_010699104.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22573445"/>
    <dbReference type="KEGG" id="lpan:LPMP_150290"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150007900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_150290"/>
    <dbReference type="eggNOG" id="ENOG502S568">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273543at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="499"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="603"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="682"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="818"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="48"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="512"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1920" mass="204760" checksum="1E1BA42ADB56E41A" modified="2014-11-26" version="1">MRASTGGSAARMAADLDEMDEKLRRLGLDVDPPITTPPSFAPSAAHNNADYIRSIRAAKEEKQQARLDRLARLATTAEKQQPLSCAPASLTAGAVANTSRADHATADDKALLVSDVVDATLRASEKSKSDRAQQRRAERTLKAAADHRQCCTKEHNQLLSASPSSSMVALSLVLTAPERRERKRQEAAVWCAGVARGLVKLAMEVSDNRHLPATGFGGRSVYRLHQDLAVTQWRQWVEQLVFPTSLSTAAVESTRRGDDGAADIDSEVADFPASKSAEVQQQLSQQALSANLHLEAAKCIASATEADTQEAVRAQAESVACVLAKLQAEVARQRKAAEEVVRLSADEANRPTLMAAQGNADVSGIPCRAELLPGWTQRMPPAACFVYGDDLSGARLLADTIDMCVQRKLHHQQQPPSSQSPHRRLTSLRQYSPVTGEGSEATAADVSSTVSSAAASPEDLLSLFAVSEIGVEGSDPALVEGGAVATYVTPRTLLSNGALSSAGGDAKRSGSAGRSQRAQLHSSAGSSNPALGSGASQGVAPTIGPGTSSGAASRAGQRVTASSPEGRRENEQLIDAVVREVVRVHRHNLGVLAGDLMPSWAPKPPVTATATGSIATEEDSKQPSFAPLASAPLRTLFLVGFPETTSFTEVLAWRLRQATATAETELIEIEGRRRAAEQQAAAATAAAAESSKQRLSPSAKGTKGGSPGPARSRGNRPAKTVAGAEEQAVSAMVEELQAAIAMPPLSVLATFLVYDLPTRQRRLKAASFATDPAAAQRSSGDDCEDDLSNLSAVVGGVLLRSVGQEYTHPVYNPSAEDIQSCGPPSMAKELSPARPTSFRQGGLSGALPSPSLPGATPTVTATPSLCMHTWSVERLRIELKQQHAQQQRQRKDWAAAVVVRKDRGSVDNLTGVLLSSTASFRHSAKRRDKPTASVNTNVATDLDRANALQRRASMSAMSRVAEPSAATAIKMLEDKGLPRALFFVHIQDVSDSTTLSTSSGDCQLDPTSLGTAIWRAAATWQPHVNDPQQECAEARARTVNELITQLRLLCRPAAGRVLTNESLAPRQLAEPFRLGDYRLTEATCVRLKKTNKAFLGTLPASPALEPFRQSGALPGGAVGAAARDALMAEAEVWAVVLQYSEQLYRLVAEEVFMDGVAHPVRPAAPPAAAMLSTTAWFTSIDQSYTRAKEAIAAYTAYTIASLEDCLALLLRFSVDVCLGQLTASVRLLCDSIERHHRIETPALFDPFTSAFVDSGENIGEELLRIVPRLSAEVARALIDSMNRVDARSASSMLSAKLGEVYWPQVTAVTAEVAVRHFASRSLHNLAGVASSATNAPQVLQQVPLVPDESESAGGSNTGAAKDAVALKSEAKIMAEEHIPSVVQLLLEHAINAPAPLARVAVLLQKPQQMVRATRDGAEAWLELLYHEVLGLHPAAPVSTVPRTRRPRSLDELADGPQIVLGSDNHDATNLPRPSPWRCGQLDLLLNSVRPAKPNIMIPVETFERGLLVYQLQRLWRFLPDVSADLAAKAKYLIGAHEAKTPAPAALLARPATSSASSGPPALPDPSLDAYLLTSCPCRPSAEQHFPFLTTADVKQLSAAAVAEAATTAAAAKPVVMVDVELWLQNLALQRCCFCANFCDPTTRVGSRQPERGSMQTPQCVRVCTAMPSSGAVRRTIATLPACVLAQHATFCTTTTPPLPSLVTTPRSSPSEMPAAWALVEWWWRGWCGDNSWSQSEDMQRCYALWRILLGHILPNPPASPDAAASTPPEMVPLLSSLMRLLVGVGKRADATEERVRRAFHCLAALRRVREGELDTRIATAEGDVNADATIFIEDEMTLTIDECAALGRLLSPTVYAVGSNAPAPTAAGSAAVAKTSEREISEHEFMTDVQLLLQVECTKGVTLPLLLSSRWASLLMKEHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLK1</accession>
    <name>A0A088RLK1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_091560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN96069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704391.1">
        <property type="nucleotide sequence ID" value="XM_010706089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLK1"/>
    <dbReference type="GeneID" id="22572726"/>
    <dbReference type="KEGG" id="lpan:LPMP_091560"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090021000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_091560"/>
    <dbReference type="eggNOG" id="ENOG502RYRR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="260887at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="20486" checksum="F7288B733D39C79E" modified="2014-11-26" version="1">MGGSGSKAKCTTAVEVPRYEDSPPESTNIGDLVLSGRYKVASPETVEMMKQIQSPREGNKMYPDSDVKDIKQYIIEQEGLHIGQARRRALSQQWRFFLSCEPMQRGLDAGIILGSLSAFVAFRKPRNRIPLKIAFIFLGGFCVGMVSVPLMVVGADSYNSQRIRKLEQELFEKQRSEFYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMV0</accession>
    <name>A0A088RMV0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_190400</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698035.1">
        <property type="nucleotide sequence ID" value="XM_010699733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMV0"/>
    <dbReference type="GeneID" id="22574094"/>
    <dbReference type="KEGG" id="lpan:LPMP_190400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190012200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_190400"/>
    <dbReference type="eggNOG" id="KOG2906">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="282152at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF12">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839039" description="DNA-directed RNA polymerase subunit" evidence="8">
        <location>
            <begin position="20"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS-type" evidence="9">
        <location>
            <begin position="116"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="6">
        <location>
            <begin position="4"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="4"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN97382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="162" mass="17316" checksum="8C484EEDDCBE04C7" modified="2014-11-26" version="1">MFFCPFCSTLLLVVPHVEGNAFMCATCRYVHTVAGTSQRVATNALGEPVLTIQHSFVEHNRQLVDAGEDPGAEAAASSSVAASCTADASTPAAKTETPVEAGTAVMDNSAEGGQITTIPCQNEDNPCRSTKAYFIQIQMRSADEPATVFFKCVECGYQWRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RN43</accession>
    <name>A0A088RN43_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_180590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697893.1">
        <property type="nucleotide sequence ID" value="XM_010699591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RN43"/>
    <dbReference type="GeneID" id="22573949"/>
    <dbReference type="KEGG" id="lpan:LPMP_180590"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180009400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_180590"/>
    <dbReference type="eggNOG" id="ENOG502S6QG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272588at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="251"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="350" mass="39684" checksum="84154A42D72F08F3" modified="2014-11-26" version="1">MIGHQLFCPHEQAQQPEDGDVEYAAISFVARDGAIHKESSIKRFVFKGDKLTGVLSDVYFNGHAVYVKEEDAYIFVSTAVNEADEKKVIVFRSEDGFVYHAISVISKLEEAEQHYLIHEGGRKLSVVSSFNRLYYTSVSSGYAGKYWSTVKMLNVSTPPASVMFSSGVQLQYACSNETSELAKWYVADGKERHTITTETPELPVVSSATARSPFLAFALKAPDSDEKKLLVLQAESKGDRQTHVRAFHFYVDDSAEEAEKAARMAKGLEEQQKKEAARLQATRERLEREKAQRRERIRKKAERKARFITLDESNVRAAKGFLEKDGEMILVRRVNKDSITWEKEIFFSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNE7</accession>
    <name>A0A088RNE7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ANC2</name>
        <name evidence="18" type="ORF">LPMP_190180</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 16">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698013.1">
        <property type="nucleotide sequence ID" value="XM_010699711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNE7"/>
    <dbReference type="GeneID" id="22574072"/>
    <dbReference type="KEGG" id="lpan:LPMP_190180"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190010300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_190180"/>
    <dbReference type="eggNOG" id="KOG0749">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269142at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000096">
        <property type="entry name" value="ADP,ATP carrier protein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF14">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="29"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="130"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="226"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AIN97360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="321" mass="35533" checksum="EEB5E3C916A03B28" modified="2014-11-26" version="1">MSAHNTAPAAAAPAPNKAHQSTPKLGFWEEFMISGVAAGAAKTAAAPIERVKLLVQNQGEMIKQGTLDRPYTGVVNCLTRTMKTEGLYSLWRGNLSNVIRYFPTQALNFAFKDQFKRMFNYKKDRDGYMKWFMGNMASGGLAGAVSLCFVYSLDYVRTRLANDTKSSKKGGERQYNGMVDCYIKTFKSDGLMGLYRGFCVSCVGIVAYRGFYFGLYDTLQPMLPVNSFIVNFMLGWVVTIVSGLISYPLDTVRRRMMMTSGTGKNYRNSFECFTHCVKSEGVVSLFRGAGANILRGIAGALVLSGVDAIKPYYIKARANRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNK7</accession>
    <name>A0A088RNK7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">tRNA pseudouridine synthase A-like protein</fullName>
            <ecNumber evidence="6">4.2.1.70</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_190880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.70" evidence="6"/>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698083.1">
        <property type="nucleotide sequence ID" value="XM_010699781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNK7"/>
    <dbReference type="GeneID" id="22574142"/>
    <dbReference type="KEGG" id="lpan:LPMP_190880"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000022400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_190880"/>
    <dbReference type="eggNOG" id="ENOG502R26P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271910at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004730">
        <property type="term" value="F:pseudouridylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.660:FF:000021">
        <property type="entry name" value="tRNA pseudouridine synthase A-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.660:FF:000050">
        <property type="entry name" value="tRNA pseudouridine synthase A-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF0">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="5">
        <location>
            <begin position="412"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="330"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="330"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN97430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="525" mass="58743" checksum="1AC23DB096E7DD58" modified="2014-11-26" version="1">MFAESARHLQWKEEHHQQPHTSPEYTEETASARLVRSPYSTVKANQREYALDEDENGNAASGTADTTLPTPLVATTDADVLEQELLDDNFLYYPPLTAISEASATEALHTHSCGEPARYVPGQQIIPPGLTRYRVDVQYQGSDFDGWYKSVQRTNKKRDAAPAGNTTVGVADYGAGSHHFARVVLEEALAVALDVPMVGVVAAVIPETGVSVRRLTCHVDVPSEVELQPRTILQRSTLWLHQRRQPLAILSCHPCHNQDFHARHSGVRRVYCYRILNRIAPPLFDAGLQWHVDRYLDVPRMQRMARLMEGTHDYGFFADTKMANALRRAAASSTGSSRGGPVVSSAHSVEHEPLTSHGLARGEAPAAPKVTIERGLSQLERAAALPTFNEYGQRVVTYQAKPHEYYKARTNLPTVRTVDKIEVVRQEDEVLIWFVGQSFLRHQIRNMVGVLKAGGHGLWDDQELQHALQSGFEVSRKKFKRERLPPAPVHGLTLWDVEYPAQHRSDFVPYVDAGPYEPIDISTQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNN7</accession>
    <name>A0A088RNN7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_201680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698369.1">
        <property type="nucleotide sequence ID" value="XM_010700067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNN7"/>
    <dbReference type="GeneID" id="22574377"/>
    <dbReference type="KEGG" id="lpan:LPMP_201680"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200022100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201680"/>
    <dbReference type="eggNOG" id="ENOG502SAWC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="261608at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="164" mass="18517" checksum="861F8475F3EE3F16" modified="2014-11-26" version="1">MLCCARLTRSAVFWATTGRRSGDAAAAAQKTTFRVRAFTDAVRDTVASGDAQHSRVDTSLQHAKEESDMPLAHVEKAPQQMPKFLFQSRRGSSSSEYYMTRSNAGHPDTVAELLGAGRTDPEWMWLKLLCFLCVSSTFGTTLYSYFFAEHMKYFKDEPWSPFTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RP03</accession>
    <name>A0A088RP03_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-isomer specific 2-hydroxyacid dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_201490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698350.1">
        <property type="nucleotide sequence ID" value="XM_010700048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RP03"/>
    <dbReference type="GeneID" id="22574358"/>
    <dbReference type="KEGG" id="lpan:LPMP_201490"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200020100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201490"/>
    <dbReference type="eggNOG" id="KOG0068">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333">
        <property type="entry name" value="2-HACID_DH_C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE NAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="3">
        <location>
            <begin position="13"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN97643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="213" mass="24157" checksum="D81C5700B25F675A" modified="2014-11-26" version="1">MLYFNRFPWRLVASKNEKKWNRFNCIELRRQKMVIIGYGDIGQACGEKATALGMEVTGIRRSGDNKADKFGVMVRGNDALDESIREADFVVGVLPGTHDTKHFFNKEFFAKMKPSAVFINIGRGMSQCEADVAEALNKGIIRGAALDVFEVEPLPKDSLLWEVPDCKLLITPHCGNLTENVIERTMEIFMDIFEEFFTHSRISAHTVCLKRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPW0</accession>
    <name>A0A088RPW0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cyclosporin 16, putative</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">CYP16</name>
        <name evidence="4" type="ORF">LPMP_180880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697922.1">
        <property type="nucleotide sequence ID" value="XM_010699620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPW0"/>
    <dbReference type="GeneID" id="22573978"/>
    <dbReference type="KEGG" id="lpan:LPMP_180880"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180011700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_180880"/>
    <dbReference type="eggNOG" id="KOG0882">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271386at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000073">
        <property type="entry name" value="Putative cyclosporin 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF6">
        <property type="entry name" value="SPLICEOSOME-ASSOCIATED PROTEIN CWC27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="3">
        <location>
            <begin position="897"/>
            <end position="1051"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN97269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1054" mass="112584" checksum="6D63509866CC0CBE" modified="2014-11-26" version="1">MHISLQDAHDVFSAETPASAHTTSLVTAQAIHDVCVHLDSLGALIATIDAAGVVRVWRKLPRGLLFITELNKVFPPACSVGATAGHERRTCHYWAHAYTALQVLVFVCVEEEAEFDLDASAAVAQTPLRTVRVHMRQVNSVTLTVEERDSFIFQVPVQRVVSAAVSAGGTALHRNDGVQRRAHDSRGAQDGACWTPRTSLAYTRRPAFLTHQYAPHIAFFVTLPPSSATPGARSGGSGVVMCPCFTSAMSTGGRSNHTAGTVRSYAPTRLSVANAIVACAQQELGLERTGTSACVLIDSGGVVDYCIIEAATAPNTLSSTASGGLTLSVMAGLAVVPPTSREARVWRQWIRFDRRQRTGFFSLVQDAQQALKVCKVDERQATADKITGAIAAADVQVLPATVQLTSDGRHVLMWSFRLLRVAATPAAVVSSQPASRIPSTERRYNMTVESCLHLLDFTTGMCIGRHTEPVGVFTTSEDLAFGATEWADYVQLRSRALALHLHTEPSATAKNQFYVMVPELPVEQLLGVRAVSHEAAEVATTEVAGRMVHVYEVTLEAAVSSPSAAQSSATVRRLSHAPGEWEAIVRRGAEHPLHGSHHNPTDVGKDSCWSGLVTSQTAWNVLHLLSPNEYGLTVKEGSHTRDEACSRAKATARAHSGLSICRAPLVLLRRAVTTSQDLKNLIAASPIGAALGADARKGLFVAPRAPDTTGGAAPGEVLLLASSVDMSSAALLVYSRERPWGSAAVGRILSEAAPLQTEEQLSEEGERLQEQRRHETWAHALRELHRGRDDVCGTLLLAAVAPQAFSTAAAPEAAGEATATSPSIIADVAGSSTNNGEAQQEKTTEAAAITSARIATTRRATPVTDEEAAVRKLLKDLIPPLSTFSPPVALVHVRGYGSIRVHLLPSIAPLATDNFVRLARRHYYDRLTFHRVIPAAIVQGGCPRGDGTGGESAFADGALFSDEGLALFPFFSHTANPLCCWLCMANAGPHTNGSQFFFTVPGGEAMPWLNGHHTVFGYAIEGLDVVRAISVAARDKEDKPLSPIMMERVDVLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPW7</accession>
    <name>A0A088RPW7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_180980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697932.1">
        <property type="nucleotide sequence ID" value="XM_010699630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPW7"/>
    <dbReference type="GeneID" id="22573988"/>
    <dbReference type="KEGG" id="lpan:LPMP_180980"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180012700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_180980"/>
    <dbReference type="eggNOG" id="ENOG502S4XZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272408at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="77"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="191" mass="22280" checksum="82EE03E5D3A5CB3E" modified="2014-11-26" version="1">MVNRRIAKGHRLARKKKLKITKKTSVDESAARAGAGKNARKRKTAATRVRVVNGVTKKQQHRFGEIESLKKQKSKLLKQQAAERMVLKEHMRDLEARKNRIRRGETAKTERRELAKYIRQLKQEQQVKHASELTNVEMELKRLINERDKVRTARVADGMNEEDVDWEDIGDADNDDVNEDELQRMFAHLTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQ18</accession>
    <name>A0A088RQ18_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_190020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697997.1">
        <property type="nucleotide sequence ID" value="XM_010699695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQ18"/>
    <dbReference type="GeneID" id="22574056"/>
    <dbReference type="KEGG" id="lpan:LPMP_190020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190008200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_190020"/>
    <dbReference type="eggNOG" id="ENOG502SE6T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265721at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="253" mass="27610" checksum="EE1E67BC135A1010" modified="2014-11-26" version="1">MVRQRTNAAAEGRGAKATPPPQKGVESQAQTPELPQTQLNPVQQPDHAQPEESSEEEVVVITTVQAPAVVEVESIPEPPAPAALVIPPHYVLEIERVVSVKLPPRVTQTAETQRGLYMFSAQAGKPPTPPPTAQQHAVYRPDTANLGTRQWSLGTDSRIQQPPQQQQAWPSASQFDYWNNSERVPASRPFMGTQAQAPYNSYPSAVPFSHQRTSGNAFPVRFRSSEVPESALRQQSAVPFNRASQPTNGGGVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQD4</accession>
    <name>A0A088RQD4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Soluble n-ethylmaleimide sensitive factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_205790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNAP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN98070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698777.1">
        <property type="nucleotide sequence ID" value="XM_010700475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQD4"/>
    <dbReference type="GeneID" id="22574791"/>
    <dbReference type="KEGG" id="lpan:LPMP_205790"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200065200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_205790"/>
    <dbReference type="eggNOG" id="KOG1586">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9984275at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005483">
        <property type="term" value="F:soluble NSF attachment protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000700">
        <property type="entry name" value="Soluble n-ethylmaleimide sensitive factor,putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000744">
        <property type="entry name" value="NSF_attach"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768:SF8">
        <property type="entry name" value="ALPHA-SOLUBLE NSF ATTACHMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768">
        <property type="entry name" value="SOLUBLE NSF ATTACHMENT PROTEIN SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14938">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00448">
        <property type="entry name" value="NSFATTACHMNT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN98070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="282" mass="31851" checksum="B0EC0D79F376C5C7" modified="2014-11-26" version="1">MSSADSMFADADKKTKKTFFKDFEGAFDLFNKAGVRYKLDKDFMRAGDAYSRAGDCAVKLGDKAGAGMAFADAVNAYKKIDAGKAKTMLDMAVRLQIENNRLSGAARLLLEFATSLEEQGSGMDAIPHYEQAMQYFKAEDQKAQAQKCMIAIGKIYGENDQYDKALMYYERIANEMLGGPLKFQAQDYFLRAMLCRYAMVTNDNRFEGSEECRDALQQYMSADIYLKNTREAEFLQLILDAVTDSDVEKFEIGVSLLQDIRKLDDWKTHVLLVVKHNMESLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQQ8</accession>
    <name>A0A088RQQ8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Small GTPase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_210840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698872.1">
        <property type="nucleotide sequence ID" value="XM_010700570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQQ8"/>
    <dbReference type="GeneID" id="22574906"/>
    <dbReference type="KEGG" id="lpan:LPMP_210840"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000050700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_210840"/>
    <dbReference type="eggNOG" id="KOG0088">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002608">
        <property type="entry name" value="Small GTP-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="236"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="286" mass="29910" checksum="DB548903254873F0" modified="2014-11-26" version="1">MDVCMKGLSFKVVLLGEGRVGKTSLISRYVYSMFDEKEASTVQASMCSSKAVPINNPSNAPGAIREVELALWDTAGQERFHALAPMYYRNADGAIIVYDVTDADTLRKVRTWAKELYAVVGEGNIQLVLCGNKADASPTEREVSEGEGAAMAAELKAAHFFASAKTGQNVAEVFSAIATQVVRSREVTGMGGGAVASGSSSGGGAYSRIGGCTPSRSRPRRGLMVVTEDGEAVIPARSSPSEGRVYGSITPPRVHRYGSSGTNQPITLSADSSLDPAAAPSNSGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQU6</accession>
    <name>A0A088RQU6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Translation release factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_211520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698937.1">
        <property type="nucleotide sequence ID" value="XM_010700635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQU6"/>
    <dbReference type="GeneID" id="22574974"/>
    <dbReference type="KEGG" id="lpan:LPMP_211520"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210019700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_211520"/>
    <dbReference type="eggNOG" id="ENOG502QSFB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2019491at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="222"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="156"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="681" mass="72744" checksum="FFB58BF78DBD45BB" modified="2014-11-26" version="1">MLRRNTSVPVLQLRLLTTATPHPSRYAAGSVALLATRRAFFGSFGKQSGNTGSAGTSSGTTTGSCAGNASSTSSKNPSTGVPPGFPPGLDLCELQTMQQLFNSQPKERQEQMMKQAMEMQKLMRKIPGFGKLTQKNTKVLEELLKMPPQTPPPPSSSTTATSANTKPASASSTSVAASVASSLRHDLFSNAGALNSQHLNGSGSSGGPSLDELRKVNLGPEIEALFQELRTIRSRKNEYRDKYHQVQSALEKLEREHKDVSTREASLRSKLTKAEQEVMLLTSENMELRDSSKSVRQLTQSNRQLKAEVDQLKTAAQSSTAPGTTTYADLQQLLHEREDALRSLQRKLDRMRRRDPLLQFSIACSNVSRLCASPKGGDDAGGTDAAAAAASEASQEAAEKAFAELQTKYQERQQAAWEAAAHDHAAAAAAYVAVVRRYVMRSVPHSNYDAVVAFTGDAAALHACFSGIGFQVEMLAGEHGKAHVTATADALPFSTTPGPFGYALALSLSSGMARVESGRAGATLPPPAFTVTSAHPFVSAILVQNTKRCRVTYDTARASGPGGQATNVAETQVYAKLAIDGAPAFTAEAQDSRSALSNREAALDKLHQQRRLQYNDTLAKQEKVELVKAQLVANIRGQGGFALEEDVHRLVQEAVIAKRVTAGDAALVKMLQQLGLLASAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQV2</accession>
    <name>A0A088RQV2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Serine/threonine-protein kinase, putative</fullName>
            <ecNumber evidence="7">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_200970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="7"/>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97589.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698296.1">
        <property type="nucleotide sequence ID" value="XM_010699994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQV2"/>
    <dbReference type="GeneID" id="22574304"/>
    <dbReference type="KEGG" id="lpan:LPMP_200970"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200014300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_200970"/>
    <dbReference type="eggNOG" id="KOG0601">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0612">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5337378at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001015">
        <property type="entry name" value="Putative serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF186">
        <property type="entry name" value="KINASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN97589.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="985" mass="104312" checksum="935099E39C2E2DF8" modified="2026-01-28" version="2">MRASIDDENSSVAVTLLPSAQVSPLISSQFPTRTGAISTATADTDAINAPGSGAASPDGGDTPSSMATMTTTNAVLYYPSAQLPTPPPLHRPSSSPALMQQSQHEVPAAVRAVPYCPLSCESDSNEEPLFQRPPPATPIVPSLAYTTSSSPLFFTSMQAPQPDRLCGAVSAKPEGGGHARGGTALYASLLPIPSTPTMATTETPGTLAGKRSAVARETSNYSLAEPTKTHVSASSSNAARIHGGYAGSSNKSTAETTVGNHSRGDRGVQRPLLMTAPNGVAVSSASPAAPVTLTNVGDTVPVAEPLPPAKQRRTIHTGVGNRGTLPSGGIGAGSGLSAAASTGAWALGAATASAAAAAGGASPKPSLRIAAPLRGFGRNPVTSHASGSVSRATTSGAGTAPPPQSFKLYRREGSRKRSADVLSQFSALDLDETPTTPFAETGACNFTSIIPNSNVHNAFPSQPSPPTTVYRGAGGGSNAIGAVSPLIIDYATPVTLSQQIGGSNTFSQVLLHPSQDVLDVSQADTECSNFLARRILTEYNEVRLLGRGSFGTVSLFKEISSGEYVAVKMSPPLRTPEMERRYRRERSVMGMVRGLPHIVQLSAAWEEGRVPRMYMQLEYCPGGSVASVANEKQDRNEPWPEAEVKVFLAHMSIALDALHRTSIAHVDFKPDNILIDRDGAYKLSDFGCSVLLDERGRPRPETRNGYGSPARGQRAGEVGGVTYVNPNSGPVVYTGPGASGLATALNPDSWNDGNELSTTSVDEGDCRYLCADMLNEKQHFKAGDMFSLGMSLFELMSGQPLPRNGDQFLALRRRVPVEMLHRRGYSADLVKLVVALLRSDPTQRPTARQVLQYLRPSSEQLQLLSSSSAMQQWTESAESFCRLQVEEQQQLLGNDGAVTATVDALRCVSALMEASMWLFTTTQQDVHRLAAPANPCKGEEEDEQRRQQLQPPPLPLLQLPRGRRLEMPIPPSQRDEACTPTTLNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQX6</accession>
    <name>A0A088RQX6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">26S proteasome non-ATPase regulatory subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_211980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698982.1">
        <property type="nucleotide sequence ID" value="XM_010700680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQX6"/>
    <dbReference type="GeneID" id="22575020"/>
    <dbReference type="KEGG" id="lpan:LPMP_211980"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210023800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_211980"/>
    <dbReference type="eggNOG" id="ENOG502RZGJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271435at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="49000" checksum="C73172F454D1CF3D" modified="2014-11-26" version="1">MHFTAMDADNIHQLAINLSSDDIAVLSDATKRLQELLRPQQIVAMLKDTSTTHALRVLLGEMELVGNTDVFHFIGRALENVFTQPSRESNAILFAPAAQFLVEFIVRSAAAADTAIASSVSKVLTQLITIAGDNAEAAAFLGPCLDSNFHSERILRLIDCDAVESVENKTVCRFLERWTSLLPFMFDATLDAFENDPLLQANYIIASGVTCRTVAVPSSLWQRMMDILRTNDDALHFVYVCRFWSIALLRHEANGKRDAAACVSAVMPAVEGSERDEKGTEAIFDLLGSAASTQAGWDAVTGQLPCKTLQVRLSGTSASLRLSTLNLMHSMLTSSHMSASFFTKDLLLDAWKTRTTPDDVVRLALWRVANAALLQESLSQMLGAMFASFLSSDAHEENVSVRLLKLTAAKQLLYHSTLPENVKTRLSQVVERGLYPAGSSGVSLTTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQX7</accession>
    <name>A0A088RQX7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ribosome maturation protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_201150</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SDO1/SBDS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698316.1">
        <property type="nucleotide sequence ID" value="XM_010700014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQX7"/>
    <dbReference type="GeneID" id="22574324"/>
    <dbReference type="KEGG" id="lpan:LPMP_201150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200016700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201150"/>
    <dbReference type="eggNOG" id="KOG2917">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253092at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.900">
        <property type="entry name" value="SBDS protein C-terminal domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018978">
        <property type="entry name" value="SDO1/SBDS_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037188">
        <property type="entry name" value="Sdo1/SBDS_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927:SF1">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09377">
        <property type="entry name" value="SBDS_domain_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109728">
        <property type="entry name" value="Hypothetical protein AF0491, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="7">
        <location>
            <begin position="16"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS central" evidence="8">
        <location>
            <begin position="112"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="276"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="321"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="392"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="338"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="455"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="468"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN97609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="530" mass="57681" checksum="6F686CAF0659ACE5" modified="2014-11-26" version="1">MSARMQVPLSQRRHTNIAVVRYSKNGVKLEIACYKNKVISYRSGTENRLDEVLQVERIFANVARGYLASEKEIQTVFGGEMTELEAIKYMLNHGELQVAQQERTAEVDEMFKDIAVIISQKCINTKTQRPFPSQVIEQALRSIGAAVKLDQPVKKQALSLMHLLIDSNVIPIARANMKIRCTTTSEAALEKLRVWCGDNDADVEKVTVMSNASGTDNGGVGHSLVLLMQPNLFRDLDHFIKEELPSGSTTHMVDAVVTEIGDSDFLLDAKTVSRANAQPGRAEETATMSGSRRATATPSLSSAGGVSGGRTDVSIVLGWNAENASSEQHPSYGEGQRGRRGKKKSTARHDHRGRRNDDSDDDDLLDSGTDGSAKGGVTVGLDIAAELHKLNLDPSRNFQDDSDDDGGRGRGGKGKRNKKNASGTGGVPPQSQVDGAKKADVGAIAMDDNDEGDRKGKKAKKNAKKGKKVESAKSVPEVEKTFSDSDEELMGNRKQRAKKQQEAHAQQGGNDWEEEGFDYSEEEEVGEQVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RR02</accession>
    <name>A0A088RR02_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_220100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699012.1">
        <property type="nucleotide sequence ID" value="XM_010700710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RR02"/>
    <dbReference type="GeneID" id="22575056"/>
    <dbReference type="KEGG" id="lpan:LPMP_220100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220006100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_220100"/>
    <dbReference type="eggNOG" id="ENOG502S640">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270452at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="244" mass="26854" checksum="34D661C450A3492C" modified="2014-11-26" version="1">MCASLLVAQTSGMPLVNTGGKKQEVTTHITSSRFTVSYASRAASLSSTVLVEPSYARSDMALQKAVVEVQKKAELTAFIAKHEKACTISEADRRLSIIMLLNSAAQRDIDEGIQAGYPKQVVNFMHQTWVAFIQQAKDFYKADADEPFTMELSHNALETTSSIGIWFIGPQISLPLRRYSVQVVGADGTLQDIIAVGLLSFTYSTYVMHLRSMSQQRVLEGLTRMQEQLGTDSLFLPQLLVAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSP3</accession>
    <name>A0A088RSP3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_211610</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698946.1">
        <property type="nucleotide sequence ID" value="XM_010700644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSP3"/>
    <dbReference type="GeneID" id="22574983"/>
    <dbReference type="KEGG" id="lpan:LPMP_211610"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210020600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_211610"/>
    <dbReference type="eggNOG" id="KOG1314">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="432"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="9">
        <location>
            <begin position="323"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="114"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN98239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="596" mass="66535" checksum="316C879D1DA70F8E" modified="2014-11-26" version="1">MDDWELVRYALERRQYLVAMWITLHKPRFIATFVASARVMGWPVIALGVALVTFTVVIIARNVVPVLATPGTVSYGLLQALVVLVSFNIYVNYFCATTFSWQIGKAPAEYAYRDPHATNPADAPHVDSNSSEDSHEDSEHANDGGQRISRNAQEMSSVAPRLQLAQHAFSSPHKGAEAPGGTFDVTLNASSSPRVPLPAVTGGAVSSRPPLPVTNFAGIRVVHVYRGYDSADRDAAVTVPLSQPNAAVVHRRGGMGSLLACPISLTRRARTVCPGRECHLGCMPYHSRPEASLATLLELETLAGVAEHYPPRLRAARVLDAPRRYCHHCRRLKAPREHHCVICDECIAKMDHHCPWINNCVGAENQRYFLLLVWWLWAGTLLASTFMGYGYIHERSNARKLRHLRRQWRTSPYKAAVEAELRALRMPYGPAGVLLTSSLAILTLGLTVIIFLCMSLFLYVNQRLVLENTTAIECIYVDEKRKRVYQSTDFTYRNPYDLGKWLNFVDLFSPARDPFVKMELEAEAETARKATVNRPGGWASDRGPRWRSTARQLVQRLAVVVWLTGFPTFRPIYGDGVHYPIFDSLASGEPHPLLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSQ5</accession>
    <name>A0A088RSQ5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNL-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_250820</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699652.1">
        <property type="nucleotide sequence ID" value="XM_010701350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSQ5"/>
    <dbReference type="GeneID" id="22575730"/>
    <dbReference type="KEGG" id="lpan:LPMP_250820"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250014200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_250820"/>
    <dbReference type="eggNOG" id="KOG3277">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="512667at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024158">
        <property type="entry name" value="Mt_import_TIM15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007853">
        <property type="entry name" value="Znf_DNL-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922">
        <property type="entry name" value="DNL-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922:SF13">
        <property type="entry name" value="DNL-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05180">
        <property type="entry name" value="zf-DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51501">
        <property type="entry name" value="ZF_DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNL-type" evidence="6">
        <location>
            <begin position="142"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="63"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN98945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="235" mass="24936" checksum="242FFBC21381DB8F" modified="2014-11-26" version="1">MLNRPTLLSVSRRLAVPRGSHVGTRIVSALDQRLQPALRTRTSCASFSVSSLVAASRRWCSTGSLSSNASNPRHSQVKTPSTDPSAVASTSLAAHHDATASATSVEEQLKMLSPEDQEHIIAALNAPENEKSSVMGGTGIGPANGDMVAAFTCGPCDYRMVKRFSKHAYTKGIVIVECPNCRSKHLLADNLGWMEDTATNIEDILKAKGESFVRIGETEGDYQVVADPAVGASSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSU3</accession>
    <name>A0A088RSU3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Galactofuranosyltransferase lpg1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LPG1L</name>
        <name evidence="6" type="ORF">LPMP_260530</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699874.1">
        <property type="nucleotide sequence ID" value="XM_010701572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSU3"/>
    <dbReference type="GeneID" id="22575956"/>
    <dbReference type="KEGG" id="lpan:LPMP_260530"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260010100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_260530"/>
    <dbReference type="eggNOG" id="ENOG502SM91">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="260282at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43179:SF12">
        <property type="entry name" value="GALACTOFURANOSYLTRANSFERASE GLFT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43179">
        <property type="entry name" value="RHAMNOSYLTRANSFERASE WBBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="157"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="172"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN99167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="652" mass="72033" checksum="C42C3008DCEB6984" modified="2014-11-26" version="1">MCSRLFTSLASSVPTSLRLPTDAGHRLSAVPLLTPFWELWAAEKTQPQDKRAHLCVCASAVMYRRRLPARLALRYKNQSRWRAPLTGVCVLVCLLLGLFVLLHTSWSDGMQPTVSMVPVPSSSLLPRLTEETILGASGPTLVSTGAPLSTLTTAATAASQPSLASDNRDNTARATGAAPAGTTHTTSDASQMMEGLERDAGELHSRYAVEIAHLDALDVFPLRPRERRISFVEFARCLGTRLSVCPDTGVEAARDDLASDRYAPFLITVTLENTQDLKALLCNLTVPYRYIVLAQNGDTPEATPFFQLLRRVFAFTTRLTVLQFLDNVGFAGAVNAGLREALAHPFSEVPFVHILHNDVRFLFSSLEQAVAGAYRTTAKDMETIETLEKEVATEPNEHTPLIWQPNGLRAPLVPGAPLPQQYSRKPVVVTSALLPDRARYMTPSQRAGMMTGHTSFMFANSRGEYTSVFLSRLAVLTVGFFDENFFPILYDDTDYRWRAHLLGFVEDRSSATSDQVISFDLDCVNQAVRDGDGDGDVEGRLGLHKRASGPTLSPEGRALQRDCRRAFYAGVQYAYMQRKWGVKAMAELMAPHTPREPFSGEAFAGKRRLPLDAWVVDTGRLTKVRRWLRDVGRIPLDVDSYNTDVILQAVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSY1</accession>
    <name>A0A088RSY1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ferredoxin reductase-like, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_252150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699785.1">
        <property type="nucleotide sequence ID" value="XM_010701483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSY1"/>
    <dbReference type="GeneID" id="22575863"/>
    <dbReference type="KEGG" id="lpan:LPMP_252150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250023700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_252150"/>
    <dbReference type="eggNOG" id="ENOG502S06W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00322">
        <property type="entry name" value="FNR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03467">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.102.10.10:FF:000032">
        <property type="entry name" value="Rieske_[2Fe-2S]_domain/Rieske-like_[2Fe-2S ]_domain_containing_protein_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054716">
        <property type="entry name" value="Sol_Rieske_ferrdox_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21496">
        <property type="entry name" value="FERREDOXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21496:SF0">
        <property type="entry name" value="RIESKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22543">
        <property type="entry name" value="Rieske_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="6">
        <location>
            <begin position="10"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN99078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="546" mass="59211" checksum="56C335B94F5A3736" modified="2014-11-26" version="1">MSADTAPDRVYVGKRLQFTNDSRQLVRCGTRNIAVVCHRNELYAIDNACYHHGGPLLLGDIEEMGGHPCIVCPWHSYRIALDTGEGLYWGIEFNPNGGKPQQAVRSKGCKQRVHKVVDLNGEVYVLVDLSGPKRESDTYASMELANGEAPMSLPVDGRARGSRAPGIHSHAGVERRSGHVFQHVELPTAGGGSTGSGGTNPLDETQKTRLPMGLTLPPKINPPGRTCSSPTTSLMVSCIAITNICPGVRQFDFVHHAGALLRHAELGEYVVLELPIKERHPTGDANVGHFPSSSITAAAAGEAMRRRWTICDVGRKGGLFSLIVKATSADTQASGSAWLHHHSLHVPLPVAHVGGTFTFADHHDTIRRVGGRVLWLTAGVSITSAYAFLNSSLGDSFYVETLEPLHVAHLHANHTLETVPKLDEFVRWQRDFPRSELETTEKASGGSDARHLRKTYAMELFITPTKDAGAGRDTSTETPPLNSCPVIPITHRRRMQPADVFSAVQKYFSADMPLTYVCGPQGFVKDCTNALLSAGVPESLILTDDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RT58</accession>
    <name>A0A088RT58_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_262140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700034.1">
        <property type="nucleotide sequence ID" value="XM_010701732.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22576117"/>
    <dbReference type="KEGG" id="lpan:LPMP_262140"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260026100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_262140"/>
    <dbReference type="eggNOG" id="ENOG502S6D3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266254at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="825"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="874"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1099"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1275"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1333"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1441"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1480"/>
            <end position="1523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="840"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="874"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="905"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="953"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1289"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1299"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1346"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1484"/>
            <end position="1493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1502"/>
            <end position="1516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1546" mass="163252" checksum="E21371BCC4218411" modified="2014-11-26" version="1">MRSRRQTVSDAVSVLGMDPWKDDRVRDFVAINTIQRLRAYHLPASAPMPVVEEINTARALNLILLPRAVPDYRPCLGEQPPSRAQLRARRCAKERQERQELRRGQQEADGGDRQGGSLSESSSASASSSSSSDDGSSVGSDTVAEHGATMPMTNPSFHTDTITPNKQSGSRSPMASGSFIAATPSTRCAIDRARSIFFGALSFTSSTSPRRLVNSPHVPLTPSTPSTMALAGWSDMHVPRSPEEALLSTTASPLSSDTRVAQRLGGREVVAAATKDDSTTAVPPVLPALSATRSLGMELDAYTEANSTPLRPPPPMRHTGVFTEVQANKTAHTVTSAEFNVSKSGMSPNTFVVASHETSTPTADVLRESTPAKAAATASPSATEQLPAALQAIPAAVGPLLPKLVGAEGDGATPPPPRHGRSSSGGAADIMHACDACDAIIQYYQSMLTRGVVLDRYNHKDLAFVWWVLGRNMDVAALENCGPLRREALMITLRNFYYTLLSTEEAKAKAAAAEAEKSHIERGELERVGGAALSAAPGDQVSLPQSADATATGDDHGVAKDTEEHAMGASGKATAHSSSAAAACAAASVICRPSQTCTRDSYKTSASVAPATSRRRKNSSVGTGRGSDTTTLKRSRPDKPFVSSKSGNKELDGNPVEEDGGTGNDKTDEQELLPAMPTRGRSRASLLPKKAHKKGTTPESRRHTVAGGAPGISSSEREKGLAVTLGVEGDEETATAAAPEGSDNVLDRKADTLHMRIESGAASLVSLATMSRAGSVAQSSTGKSHRHHRCAAERNKIIEETWISTRTERRTAAIKVATKLELHGGAEAMTNRKPMEAGPSAAASRASRTATAKTSKEKTFATAAVKDVDDTAASVAPSAPSSGSATSKVQRRNSTALKRERSPSRESSTSESHGSHSSGGGGDVVPTTGEASGHTTEVPHPASYERARRGKNTTAARAKASAVRAEKASASSAAATTTSTKAGRGEEHRGRPRGSFKTPRISPPAIEDQGNCGLVSVARSSQRRRDGGAPSTTVLTGASSEMAVRDQRFDAVGIAVASPFPELFKDGEGATPFEFPVSEIPLRLTPHERAVRSRIQQRMGMPLPAPPPRRSTGPISRDSNIDAQWPTVYSSYTFLLSSFRTAASTQRSYGGRSHERRAITAPFLWYGQAISPVVASESTSTSSSGVDYRRPASGKTVAVAVTSTRQRGRKRRIEGGVDPSLRGNVLWHDQAALERLVNGRLAQVAELGQAAVSRVVGGGQSKYCAAWSVIAHMKQEQRSGSEEEEKNDDEAHAKREEAAAVPAVGSPVPLTGSSPVVAATTSFDRVLRTGKDEAATGEEPPLPEQHPNNSAQHVLSPQTSDFGDLPYAQQCLLVWSAAGLLERHAHQRQMAAARRERLLARCSRMATRRMAARVAAVMQSGITDGDGCGNAEDVATQLAGELGGSDVDSNSGASEEESNVSEEERAVAEKACSCLLGRPSKASRKAEVEEHPSHLGRTSNQSTTSRSSSAASSSTSSEERLCRSIRPLPRRVYDYWAAYRSASDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTD3</accession>
    <name>A0A088RTD3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_261300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699950.1">
        <property type="nucleotide sequence ID" value="XM_010701648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTD3"/>
    <dbReference type="GeneID" id="22576033"/>
    <dbReference type="KEGG" id="lpan:LPMP_261300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260017900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_261300"/>
    <dbReference type="eggNOG" id="ENOG502S0XJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272326at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="CDD" id="cd23652">
        <property type="entry name" value="mS38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839070" evidence="2">
        <location>
            <begin position="20"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="277" mass="30618" checksum="18D5237CE7992A46" modified="2014-11-26" version="1">MKCSAALFHVASAVAAAVARNHSSTPYREENETATVRNCRNQSTLIDHRNQSARYRGGRCGTFLDVTPLTPPASAFHAAAANGSTFVDQNSSTVATSFNENYRIKSFRQRVCAATDVSMRPLLLLLKDVPELNDVAANAGIVSPAAATIASGRFKYGELLERLSCRWAAKFYGKVTYGPRNYPYPSSRWLARRFQMKKHRILKRFRFRRYKLAAVANLPFAKMIRVGMLPELKSSKTKKGDTVDMGLSSQLVSAARSSAGAAKTKGKRSRPKSKYQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTH0</accession>
    <name>A0A088RTH0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_260610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699882.1">
        <property type="nucleotide sequence ID" value="XM_010701580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTH0"/>
    <dbReference type="GeneID" id="22575964"/>
    <dbReference type="KEGG" id="lpan:LPMP_260610"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260010900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_260610"/>
    <dbReference type="eggNOG" id="ENOG502RZKA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271130at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="416" mass="45320" checksum="D69E56C10F90358B" modified="2014-11-26" version="1">MYREEADGSALVWGIPAAPFVPVQHFQIDVSTLNRLSSYCLRLARERGWLQTPDDVVHATPYAQRNEAHPLVGQGSHVYTGPDSTFFFAGTEEILEDPHPNFQFPPTLSTLFVKAHFYLVHVGSSSYSVYTKLYTYLDGQEETARDLLGSFKVTAVWVSKKLRIPTALPADKQLLLRSIAAKNAAKLSSSDSARTKRISVSDLLLHSGWFANAAAIASMELAAYSPLSAPPASEFLVSLPHVHSAAPLWLLHRRHFSLREADIDFNLHVNQLVTKLFVIDTFRGAAGDARCAYSRLLLPGVPLNRADLLLRKFRIDYVREIPMGCAATEVFLFPADPGRAKVQFSSVGTSTGCRDVDAATAAAALHSDAALAPPAAADMMDIGFFVVGVLRLDGASSSDRFIATVGVMTAATCFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUY0</accession>
    <name>A0A088RUY0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_282000</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99833.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700540.1">
        <property type="nucleotide sequence ID" value="XM_010702238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUY0"/>
    <dbReference type="GeneID" id="22576645"/>
    <dbReference type="KEGG" id="lpan:LPMP_282000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280026500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_282000"/>
    <dbReference type="eggNOG" id="KOG1311">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4096362at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF43">
        <property type="entry name" value="PALMITOYLTRANSFERASE APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN99833.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="457" mass="51622" checksum="A480A38017ABA8DA" modified="2026-01-28" version="2">MSLSTHRPVKGITYGVVCPACCNPMDFECVSERMYGARCPTCNAMVDLRNPAETLPDPDTGIYENDARPREAVFYSAEVEPSTGMSASAQVNNLLARVEAEKRMTMPTQMTGETKQAFFAQRQQAFSEKFSLFFPVTYVVEYIAFGREPYARIGHVRIFRKRIPFYGYVNICAPRMTTSYAAPATLTLGCFLLFRWFCIHMGLEWMAAYYYVELTLVSLFYTLLFRLAYSDPGYVKPGYMDDEGGDSAAAAPEVMTLRDIELNQRESIWEDVNGVPMERKWCSTCNMHRPVRAAHCYICGLCCFDHDHHCGVLGICVGSRRIEMFVTLVSVVAVACILPTVVVTCALWTHSEKITTPFQVVACALALVVPGFLSIVLTMTAVSMCQSITHEATTRERIQNVYAHKRNPYNRGFLGNLYYHFVQRRVEKSLFSDEFVKRCALRTQERELGTGVTVTCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RV11</accession>
    <name>A0A088RV11_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_280860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99720.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700427.1">
        <property type="nucleotide sequence ID" value="XM_010702125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RV11"/>
    <dbReference type="GeneID" id="22576531"/>
    <dbReference type="KEGG" id="lpan:LPMP_280860"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280014000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_280860"/>
    <dbReference type="eggNOG" id="ENOG502SIEF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="262576at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99720.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="248" mass="26877" checksum="070ABB422C7E9CE6" modified="2026-01-28" version="2">MISWTRRNHARCASLLRYRGEVAHFSSDTQTGLVRLVTRLCANTAATLSGISVAAMRDEEVKLQSQAACGAQCVAFSSKQVFVPATPLNADTVQDEDALEATAECIFPCYISCGCPVLVQILPGHQYSNLSEAEEKSVSCAPSSMQVRRLYMLTPAGSKHGIHDPQRTSYYTRLPDATFQCWQKHNKVIDSVLDAGKECLTSPLHKRFTGLSSLDVEVLELLNLTKTLGCVTDGSGAASVNSTRNTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RV25</accession>
    <name>A0A088RV25_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Qc-SNARE protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_290620</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700670.1">
        <property type="nucleotide sequence ID" value="XM_010702368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RV25"/>
    <dbReference type="GeneID" id="22576826"/>
    <dbReference type="KEGG" id="lpan:LPMP_290620"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290010300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_290620"/>
    <dbReference type="eggNOG" id="ENOG502S969">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="261831at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15853">
        <property type="entry name" value="SNARE_Bet1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039899">
        <property type="entry name" value="BET1_SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="48"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIO00013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="139" mass="15739" checksum="AF737E1DCC28ABA9" modified="2014-11-26" version="1">MIQPQSTLFRRREGGADNDGAFSSPSSSPAPYQTRPGAAAAAPVRADASQEQENDVLMQALLSDMRRAKKSFTRMGDEVREQNAVLERLRASFLTAQNSLRQTMRHLDKVGWGGFKHMWALALFVIVFFMLLYLMLRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RV88</accession>
    <name>A0A088RV88_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_260250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699846.1">
        <property type="nucleotide sequence ID" value="XM_010701544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RV88"/>
    <dbReference type="GeneID" id="22575928"/>
    <dbReference type="KEGG" id="lpan:LPMP_260250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260007300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_260250"/>
    <dbReference type="eggNOG" id="ENOG502RSP2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273242at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1106" mass="119292" checksum="3971D9FB961E64D2" modified="2014-11-26" version="1">MDTSSCTRVADELSVVHLSSLHEGVLQLRGHLRSALLADSPQTEMVVYTSLYKLYREFYLPFYCAKSHGSSRSLPGVDAAPSPDARPPASAEAWFVMTSYTQDVLAACVYLLDPASLPTTYTVPSLPPGCEEAGNEANASSVYVSAAQRRFCGLIFLYTCWSSATLPLHIVLQALYPLLDPGVPGAPPAAAAALSTIPSTLPGPQRTNLTENHIAAELFAKERFASHKRLLSDTLTGLVLTRPNGVRALLRVLLLNDRVQTDMAGEAVQLLVQLLTSPVVTLWRQQQQLDEAVGDRSSLSAEGEEEGALSVVVTHVTTGLSVEDHVRLLAPQLLALLEEHADATSVVSSASATAVRPRFLARLGAGHLRLPAETLEQRLHLVLTVLLNALVRLPPRSRQDFPRAYRQFFYTNKYVLSPGFGCLALRCDTLVTEGETIAALLRLRSLLKGVSLGAGCGVIAQVLPATAAGVLSICALLSGSVDGEGKAAQFVSPLLSATLRRLLTELLSNPSLYEVCARALVSACGEARSQYYMQVNDAQSRLRYAGRVCRRGYLAAGLQWLLLDVAATTPDFVQACVDVMVETCHLELFAAGVEDVAVPPVPRLTETMSSTLATTSLVDAPTAKVDSSPLVAVLERLSLEASPEALFGARDVSLASTLELLGRMLRLSGVLYRWALGLMEHLLSAANVESHLCGGGTAAERRRNLSRLQRCTRSILASLTVLNNPTHSSEVCHSVVDGGNALLPLTARAGQALEACLKRIDACLTSSEAVAQLPDDNSRRQGEVITAIRAEWLQLAERLRAALDSRAAVNVAVTLTMLAHRVDDLVFAVTDPQPLYASSRLLLQLLVRALFEADDIGAALRAVHCVTWLGMYRFDSKDSSYMADVMWSVLTEDRLPSWLAASTGCNCATQAAAASRWCRLRVRVLDILLSWTDYDEDGCTLRNLDDTMRRKRHTSLYEVLVALCHSTQDAFVQVAALHFIGAYALAMQPHVPIFEICELCRDVFRLSRHEMAKAACAATLGKVVASLCQTSGATLPAVSEVDIGTLQTLASAMSSYRGRPLVESSASVTAHALNAAVEVDLHDAVIQQHGREMLALLRGISLDSGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVI4</accession>
    <name>A0A088RVI4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_291850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700790.1">
        <property type="nucleotide sequence ID" value="XM_010702488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVI4"/>
    <dbReference type="GeneID" id="22576948"/>
    <dbReference type="KEGG" id="lpan:LPMP_291850"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000008300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_291850"/>
    <dbReference type="eggNOG" id="ENOG502S6RQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271035at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="60"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="332" mass="37668" checksum="DA4785A8FF60DFBD" modified="2014-11-26" version="1">MEYVDTYGGSGGGGRLRSGAQESTTATGATRPYLEQRTAAPVTSALGQELDRLVGGTLAAQEYRDRLEALTRSVQASDEKVLNLTRLVKLSQSIQEEKETDLQRQNDELRARLKRQEQLTTQLQRQLEDMQAAVDVQAFHQVVARLEGQVSAYKGRQEEEWVSLQQRIGELEERLQRTSTCTAEHCEQRLMQLDERLQQITHSTADATNQWAKRNFIRLKEHVDSLRVDLDDVRGGQQELKSTVQSASCRAEVEYKKVLLLLQQKTKEADALSSLVEKELQHLQKVAHRHQILASKDITPAFEFDEKPYDALKFAGEGKRRGAVSAADRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVL1</accession>
    <name>A0A088RVL1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WD repeat domain 34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_290100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIN99960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700903.1">
        <property type="nucleotide sequence ID" value="XM_010702601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVL1"/>
    <dbReference type="GeneID" id="22576774"/>
    <dbReference type="KEGG" id="lpan:LPMP_290100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290006000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_290100"/>
    <dbReference type="eggNOG" id="KOG1587">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="445052at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097014">
        <property type="term" value="C:ciliary plasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001472">
        <property type="entry name" value="WD_domain_-_G-beta_repeat_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF26">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 2 INTERMEDIATE CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN99960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="535" mass="58719" checksum="10522F7BB5B38F9B" modified="2014-11-26" version="1">MADACEFKNQITGEVTIPPRRKRETTLEDAETQMSKLKVKIHEVQTDVSCFQVSDQLDKGVGTEQRSSQATLEGLQYVYSGVPHNEAELSTFLEQSMDKLLAILHRNATSSVFDDYSPSWSRKNTKLSVLYTLTSPAAKEHNLEALGVAWNAHGNIVAAAYGLMETSGWCHKKGYVCVWNLARPDLRENSPHYTLEMRTSATSIAFHPTEPCMLAVGTYSGEVVVFPSVTESVPQQYSSLASEVAHTEPVTVLQWVKNPQEPRRDHRYVLCSASQSGLIILWSPMNKLSRPVAAYSVRSRRHLTVGITALTYGGVHSERGIYSPALDGVLLVGLENGEVGCGRTWPLPIGTNSQESCTTVPLELDWLESHCGPLQSLSASPFLRHLFLTTSSDCSARLYSDLERSPLLTLEPSAETKGYLYDGQFSPFRPSVVAVVSRSSFLRVYDLQRDQLGPVYTAAVPSEGGVLKVAFNSSAAEWLATSDARGVVHVWRLPTGLSQVTELERAALRASQPTRDGPKEVQGLTALLSLFGSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVN3</accession>
    <name>A0A088RVN3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_292310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700835.1">
        <property type="nucleotide sequence ID" value="XM_010702533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVN3"/>
    <dbReference type="GeneID" id="22576994"/>
    <dbReference type="KEGG" id="lpan:LPMP_292310"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290025300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_292310"/>
    <dbReference type="eggNOG" id="ENOG502SMJR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="263863at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="413" mass="42413" checksum="7B248EB517E082DE" modified="2014-11-26" version="1">MFNPYDPRRVYIDPNPSSASISFPYTSATDSTQVPLGSRPEGNVLYVTPPFPSQVSGTPSASNSTTEFANSQLLGTHSASLKTGETSTAATMGAPATAASSVSLVNLMQPSQSPSNISYDPSRMSSNTTTSFSRYPAAQTVFSQPNTPLQATQTQILQQPLVLQAHSPSQAFTAQGAAATPPSRQRLMLISGPAPTTSMNPFYPYQTAAATGAAAAIQSGSSHHPPSTTTQLISPLQLTSPTSQGHAGSGNFAYVVESGSPAPLLAYSVSQPPFVSIASQHWPPAAAVTMLSSASETPTMAPRESTSGVDAASLQSPTPDVLSRGAMESQGHYPGSFLTSSDTALANMSAVRAGGTTAAAGGSPEGMQPAALGVRNFSAPEPVGSCLLPNLPLDPIIPPLALPCPRWGKLPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RW06</accession>
    <name>A0A088RW06_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_291460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700753.1">
        <property type="nucleotide sequence ID" value="XM_010702451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RW06"/>
    <dbReference type="GeneID" id="22576910"/>
    <dbReference type="KEGG" id="lpan:LPMP_291460"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290018700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_291460"/>
    <dbReference type="eggNOG" id="ENOG502SKE7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267202at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="787"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="925"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1121"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="787"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1121"/>
            <end position="1137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1256" mass="133144" checksum="6F1AB1DD34D05609" modified="2014-11-26" version="1">MDSQEQQQQHRSSVQKSENICHLLQLYSGHHQRKPSQPGAHHTSSPATSNKSPVMVPDVRFSVCNTTPPSVLPPNRKPLEHPDLPTFAITSILSPSQVLNASVSTSASSIASSTPVRARPTNSMHSCAPESLQLQQCPLPHFGEAVLPLSPRKTGDARPLRRSHAVSCENGHGVNAPLAQCLSSSKRSVQDARGAKTGLGDIGMHVRISATGLMPILPVTATHPAAATDYPMSAATPSLPMPRIPHQKRGDRRALHRCNDSGSGNPPRVTDELGELYPSITLVPPLTATVRVTQAKAATGRSTTLQPRPPFTCVPFMPYHPSVVVRPQPAQSSNPSESRFGAPDAFGRSTLAESLSHTSHMFATGYGASEGSEQLRLLSPHPQASLKLLDPEEVSEDRSDSLKVLSPWPPSQLQSSLTCPFSTPDGAEGKSHTDSFVGVSDTLYSRQLDSERFPILSSTCRRVAYSVNASRDMPVVLPFIDPFAEFEGMPCGRRTSSSTTGLLASFGTPAGTMNSSDSVLENSVAALPGSGSMQTRSWALGPPPARSGGSSCATHAYPSSGRVSMATMCAVESSYALAEAQPGRFLCPASEEKQHQVCEQPPNHDFQKICDTAALTTPRSTHHSAAHISTLEASINGCSVVQSSLTAITALCARRKPLDGQKRKQLLGSCTSQHCRPREMRGTSTRVDSVAAISDTVTATTIFTTPSFTCTVLPQGTATPTTLSSRVSLSASKLLVGGIVLGASPQVAVAAAATQAAEEGIETGMSHGSSLRLLERQWASPSCSASTLSMCSSPRGRSNRGPAAAGGRSGRGGQRHDDFQCPSFISVPPLVYGAQAPPFCSLTASGVRAWVEECSVDAPIDICATSLSSLFCKTDSQLRTADSSVSGRRNLRGSMPHGECAVGVSGVLRPSYSFHRSRLALPSEAKRSGGCSSRRKSPLPPSLPATVDNLTNNSPFQGAVFVDSCAPSVVKGHESDAGSVAATTTTMTTTAVTTIARLTSRVIASQRGPSNTYMEDEGTEMVSDMRMSFAPARNAAIMISTVREEMRPSRIRLMDTMLEHPDAPPFAKAAAQRLHERRTHQLQQAQSPGTYCPPDLVRSDVVSAAAEVPVIVTTTTSIRSCSGMSNSCTTQPQTSSGAAAGADDPHNQEQVLPLPSHKQGRARQLSASLVPCLYHAYHYPCDVHKHSKQQQHTTMVSFESVKAINPLQPNALVPRAIVDASTPVSGCLTATEEHLPKVLPVKPSGLHYSIKCLFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RW22</accession>
    <name>A0A088RW22_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_291630</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700768.1">
        <property type="nucleotide sequence ID" value="XM_010702466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RW22"/>
    <dbReference type="GeneID" id="22576926"/>
    <dbReference type="KEGG" id="lpan:LPMP_291630"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290020500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_291630"/>
    <dbReference type="eggNOG" id="KOG2111">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1667587at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="55"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO00111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="374" mass="38672" checksum="0460B6C49142D756" modified="2014-11-26" version="1">MYRPLNPRGVLDLSAAVPSRKAGGDISYAVAFPQSARGYRGDVTVLTLHSVPPTSLRQMQAGDDGRPVSAASASVDTGRTSTGTTAAGDVITSSAFGTATPPTEQRTIPAHHHAVAHLRFRPDGQLLATASELGTTVKIFDSVTGALLVALQRGHRPAAVLSLAVQQDAHRVAALSANGTLHVFDCAVIVQAWESARVTSVSSPLPARSAPSPTMIGGAAGASKVRAECKHKVTLMPRPAASASASLAKSTHRRRGNSFMAAAAASSRANTAASYAEASSPTPGVGVAANDGWLHCETGFAADGQTVWVVQVQSTEAQLQHAISIATSKSATQSPRLCVGSLACFPLPSPNRCRFSGAILPTDKGEERYHYVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RW80</accession>
    <name>A0A088RW80_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ferric reductase transmembrane protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_302000</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701223.1">
        <property type="nucleotide sequence ID" value="XM_010702921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RW80"/>
    <dbReference type="GeneID" id="22577253"/>
    <dbReference type="KEGG" id="lpan:LPMP_302000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300024200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_302000"/>
    <dbReference type="eggNOG" id="ENOG502SGFT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="261545at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140575">
        <property type="term" value="F:transmembrane monodehydroascorbate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045150">
        <property type="entry name" value="CYB561D1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422:SF45">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422">
        <property type="entry name" value="OS05G0565100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="12">
        <location>
            <begin position="108"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIO00423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="235" mass="25873" checksum="4285350E0E2AF9A1" modified="2014-11-26" version="1">MTTTINEAKQLDIHGISPSRGDLKSLCRRLAAIGIIAPVSIQLFHKSGSYTDVFQYHPICMMMAFVMVMPDVVSSIRRLRLARQRSPRKSNDIAKPLDEQLSRSEIIIRHQLATFVMELAAAGGFAAVEYIKITHNYQHLKSLHGSVGALCGVTIVCQMVLGCILRYVLSPVDPKRLMVRRAHKYVSATIAVLAMMAMCGGFLATEYAEKMIPCSMIRTVIVLASAATTVAGFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWS0</accession>
    <name>A0A088RWS0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="13">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">LPMP_310160</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="13"/>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701408.1">
        <property type="nucleotide sequence ID" value="XM_010703106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWS0"/>
    <dbReference type="GeneID" id="22577442"/>
    <dbReference type="KEGG" id="lpan:LPMP_310160"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310006600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_310160"/>
    <dbReference type="eggNOG" id="KOG0214">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.150:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1070.20:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000014">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000013">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13 22" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13 22" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 13 22" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="18">
        <location>
            <begin position="50"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="271"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="19">
        <location>
            <begin position="480"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="20">
        <location>
            <begin position="580"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="21">
        <location>
            <begin position="669"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="15">
        <location>
            <begin position="718"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="16">
        <location>
            <begin position="1091"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="AIO00608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1185" mass="133649" checksum="A5EE2ABC2F6F38B7" modified="2014-11-26" version="1">MAQDELLDLEDPDMVLDDGFIDERDDENPNDDLDSEDIWEVISSFFREKGLVHQQLDSYNDFLMRIPKMIESMAVIPRQDDQYDPGVTMEEQRDQPRLVLQDVVIGNPSHQTHSYFAGGPLPPLFPNECRLRDMTYDAQAQVTLGVELYHPHADTPHDTFLRNVELGRIPIMLKSMRCNLSGKDEDELPRLNECPHDQGGYFVINGTEKVLIAQERQAANHVYAFSRQKGLLCEVKSIVEGSLNKPRTLQIIMPYRNRGPGSGFESLMCRVAQMDETIPLFVLFRAMDMVADKEILQTVVPDLKDTAMLELLRGSMSDASTLQIFTREEALGYIGRRLGKQDAMANLQREAESLLMRDLLPHMGTDPSANRTKCLYMGYMVHKLLLVALGRHEETDRDFLGHKRIDVAGTLLTVQLQTFLAQVRKEMIKTLQDHAANPRGVFSFGRVIHSRLVTDGLRRCLATGNFGDLKTGNIKTGVAQTLNRLTYSSSLSNLRRIQNPIAASSKATRPRNLHCTQWGYICPVETPEGGSIGLLKNVALMCLMSRGTDHAEVVQAVQARIDGFRTIGLEDTADVRVARVFVNGTMIGVDRNPERLLHDLRTRRRNGELSNEVSIVRDIRDREIRVFSDGGRCLRPLFVVENCHLKLRKSSIRDLLVSEKAGGKKSISWNTVLKKGYVELIDCEEEDSLLVAMTPSEVEKNYYYSHCEMDPSMILGICASIIPYPNHNQSPRNTYQSAMGKQAMGIYASNFNMRMDTTAHVLFYPQKPLVRTKAMTYMHSNDLPAGHNAVVAISCYSGYNQEDSIIMSRSAVERGFFRSAFWRSFKAKEERQKRDALETFENPNREVCRVKRADYSKLDTDGLIKPGMRVLGGDVVVGKTIPLPEADLDKLTTGNTKITKRDASITSRTTEKGVVEKVMLTMNNSDRFAKVKIRTIKIPNIGDKFCSRHGQKGTNGIQFRQEDMPFNRDGVVPDLIINPHAIPSRMTVAHLIETLAGKVACYKGGEVYATPFCSVVVDDFGKALHALGSQRYGNECLYNGHTGLPLDHLIFFGPTFYQRLKHLSGDKIHARPRGPLQPLVRQPTEGRAHEGGLRFGEMERDCMLSYGASQWLRERLFRVSDYYTVHVCNHCGTICVADTKLNRYQCKGCENDTRISQVLMPYACKLLFQELMSMTILPRLGTGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RX89</accession>
    <name>A0A088RX89_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_303340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701356.1">
        <property type="nucleotide sequence ID" value="XM_010703054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RX89"/>
    <dbReference type="GeneID" id="22577387"/>
    <dbReference type="KEGG" id="lpan:LPMP_303340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300038300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_303340"/>
    <dbReference type="eggNOG" id="ENOG502SBWJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268010at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="154"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="375"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="403"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="434"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO00556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="552" mass="57821" checksum="8F7AAA585865713D" modified="2014-11-26" version="1">MGGCCKGERCPFSHELVQLAPKGVDVSGGYFISGNVANYKAAASSTAAPSSSRSLASRWDDPTTSSSTDGLSTLVSPSSCCVTMGTSLSAEAKEWVSADSTAASSSTNSATASIKPIQSQRGATSPNICARFSSLRYRSAAARRTAHAVSPLLMPHAQGNSKPQPQQVQTQPQPQSFQEKLPSPPLPPSPQPHEQHKRQYQQLPQPRSAANTLSALLSNHSESSAAAEARPTSPVPAHPAATARTVPFKQSSSDSGALPIATLASFNAPCASTAVLSATPSSAMLQPSNVAFLRRHDDQTPPAAAAQSFTSSRTATILATATPTPAHGSRRTATRGQHVESPLPRTREALATDVEHHAATVANARTLQSTAALTAVAAPKSSPHYEVRTVSSAQTRVMPPAPRSQQQQAVHQAQQHAQLQPRQQETQPQKQQQTVYMVTTSRPPATTPWQGSLAAPAQLPLGYTLAYAIPASTSTAPMTTPILISEQPSTARPAYTLLSSCPPQSQLQSFRTTTGTVLYAAPVQALPQAAAPSESEAPRLVLANIDGIFTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXB8</accession>
    <name>A0A088RXB8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptide methionine sulfoxide reductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_282820</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700621.1">
        <property type="nucleotide sequence ID" value="XM_010702319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXB8"/>
    <dbReference type="GeneID" id="22576727"/>
    <dbReference type="KEGG" id="lpan:LPMP_282820"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280034800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_282820"/>
    <dbReference type="eggNOG" id="KOG0856">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="44061at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.20">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46081">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46081:SF8">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MsrB" evidence="6">
        <location>
            <begin position="22"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN99914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="146" mass="16330" checksum="EB0AC050474DA49E" modified="2014-11-26" version="1">MAKPLTNCAAPHEKDGSKDVGDAEWRRVLTSQEYYILREKGTDPVGGKYDDVFEEGVYVCAGCKTPLYLSSMKFACGCGWPGFYDCIPKRVREQPDRDGHRVEIVCNACNGHLGHVFRNEGFRNPPPNERHCVNNTSIVLQPTKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXF3</accession>
    <name>A0A088RXF3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">AAT25-1</name>
        <name evidence="7" type="ORF">LPMP_310550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701444.1">
        <property type="nucleotide sequence ID" value="XM_010703142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXF3"/>
    <dbReference type="GeneID" id="22577481"/>
    <dbReference type="KEGG" id="lpan:LPMP_310550"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310010500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_310550"/>
    <dbReference type="eggNOG" id="KOG1305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28208at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF690">
        <property type="entry name" value="ACID TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="406"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="75"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO00644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="472" mass="51293" checksum="257981F9875BD443" modified="2014-11-26" version="1">MESPVAKQELNILPEQDVPQEGNLYVNKLIGLDSPHGNKPSAQVYQDGSSDSKSKSDSNLHTISRLLQVMIPYGGMVSSCFSMASTTIGAGILGLPAAFHSVGIIMATVYLVLITAETVYSMRLLVQVSDRTGLHSFEQMAKHLLHTHADIFVAIIRALHIFGGAVAYVVTIGDLLKPILSSFASTPSLLLTSVGLKLLTTGLWLVFMFPLVLPRKINSLRYVSAFGILFILYLAFVVIIHSAMNGMSASPRPTTRLINSGNTAIEGLGVFIFSYMCQINCVEVALEMRPRNVRRFTICATVSMTICGVLYYITGLFGYLDFGEVQGSILLHYNPVKQPQVFVAYVGVFIKICASFGLLNNACRSALFPLLGWDPYTVVYWKYFIGAVSLAVLILMLGLFVPNVNIVFGFTGGFCGGFVGFILPALFVMFAGGWSLRSVGVINYCCTYLILIAGVVAIVFGTAATIYRIVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXS3</accession>
    <name>A0A088RXS3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_312060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701594.1">
        <property type="nucleotide sequence ID" value="XM_010703292.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22577632"/>
    <dbReference type="KEGG" id="lpan:LPMP_312060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310027500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_312060"/>
    <dbReference type="eggNOG" id="ENOG502S92X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266530at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="593"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="935"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="985"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1442"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1520"/>
            <end position="1557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1800"/>
            <end position="1896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1977"/>
            <end position="2013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="935"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="985"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1453"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1811"/>
            <end position="1832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1850"/>
            <end position="1861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1882"/>
            <end position="1892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2013" mass="214342" checksum="5A4D94280CB36314" modified="2014-11-26" version="1">MSSAARQAHPVDVAASEGATSFLRAKNLPEAISLTNTPGKVCSSAASAAEDASARSCASGVSLMSPSRISSEVYTSSHHTESRQRSSSSEAQAGVMPEALHEMGIIGSARNGKDLPATLHTPTTKLKAQKHGKPLAVKLHPPPSAAVERPTLPPSSHTPEKVQPTFSSFNPLRKDSAQPLSDLFSLQIPSSHTQKSKTLSSEQLPPTHPKITGAPKVPQNLDQRGMSSVACSNVHLSVLADLLEKKVFSEEDVLLELEAIRKRSLLTSTPFNRRLLPILAWYLLRDKFGEEAATRYVFLLTSPAGVPRSDGAVNTTLTIASFLPRVNTIRRVRREAKESNRKKPMHHYAIAPPACPTETAKLCDVKGAHHQRQHLRRVPAFDALEDASDIPTACPTDRFSLKSPITRSSPCLRSVSPLQYGRLRVYTRAHAAVDRQAAKAEDRPVVDVIMDAADPQARAKNAFEIVQAEASSVVEEPSVFHGFGHQSPAARGPATKLTSKRRSPIPPASAHPTGALAEATARSRHGLQVHGSQGCEMLSVTPSAGAFSGIAPATDTEEGLSLFYRERAEGVGQECMPSASVFWQAITPPHTSAGGKASGRRCLPAKHSQHRHLDRSASPADVMGAVTPCLSSILAVRDYDASAQQSGLASETVNAPDLSTMTSATTSSHSWVEYSHGVAGDRKYYNAELDVILEDAPSQALTSATAYSALNDLHESPVGDDDAEHAAGTAHCPAISSPLQGRSVAEASPPCAPEVTDTSRYQREQQSYSYMNGAENSMSRTVKATEHYSMLLNTSTAAHRPACLLCSRSAEVRENSNTKLPGMAQAFQPESTIEKKHSYSSLLESHIDTVAKSSTERIATERRDSDSHTVAEYSAFICAEASAMEPSTSGAVQSQAIKTSETWRSDTSATTAAAVSIVDPSANMVHSTQQSTCGILNTPTTSRSRMPCSDLHSSRRVERKAQLCGRPATESSLDDTPVYSISFSRTNTHHSSPSTRINGSSYAASAPGGESGFGNLLRTNVEASALGSGDDLRGSLAESFPSIAFPGASVHQNSVLPGGTSTNAEGSCAYQNIRCSNFIQHSANQHGQRKTHLRTSASLPPTASATTLLRESPDHRPSSSDANVRRSLSDALAAPFGDSFSMHNLTAKANDTSQTIHSHHPPPTHSTTAPAMENFGSLVEHHSVHLRGGYGSVMEGDSAVAPDASLALRSAGGYGSVMEGDSAVAPNASLASRSAGGYGSVMEGDSAVAPNASLALRSAGGYGSVMEGDSAVAPNASLASRSAGGYGSVMEGDSAVAPDASLASRSAGGYGSVMEGDSGFPLCSQTGISAIPSALTATIIDETASWMCTALWRCGRGDAETLNSSMDPAELTEALQKLGEGQGSCVKDNSACTFGEVGCYCDTERRRTCTMAATTQAPRLLQPAPPLEANSRGQAFDRFAMRSSPSEKGAGSESRSTAPPASVPLQTMLNTAVQYQCHQRTSCVSSAEILGQRSGTPVRVEGGLTLRVFPSPARCAEKVSTKQAPQHLSAASKLGTATVAPGKSASPGRCKERDASHTKSFLERNGFRSHVTILTDPRSSTDLSVHNIPDICLSRGDKSIEQLCEHEYLDYEVSGHHRVDFPMIAPVSILQNSLGNSRLHDTKTSEVARPPAAAAAPCRVKACDGETVWGMETADDSVATGCISPFPLPPDATVVNPTAGALSDESLRMPRNMTTMLFVDANQSGRLSFMQAVHGEASTARDSEEVDKPEVSLGVCATRKNLPTCLVHSWLDASHVIDNHRAFRPDASAAAVRMRLSNADHSRSVGVSHSENTEKDVTAVDEMPMDRSDESSKNATSAGRETGKSGVLVSPSTDPTNTQPAANMPECRFAHRPSLHPYSCTGDDHNSSVRREQRPRRHTILDVPGVPYVASPDISLHTDMREAQRKEKERELFAMRWAQRGLMWQRQENEAQRYEEYQARFGAGERVSGCPRMKKLSLQGAPILQRPGPLNDPRSPMPMRPRSLGYSPQGRHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXX8</accession>
    <name>A0A088RXX8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Paraflagellar rod protein 1D, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_291770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700782.1">
        <property type="nucleotide sequence ID" value="XM_010702480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXX8"/>
    <dbReference type="GeneID" id="22576940"/>
    <dbReference type="KEGG" id="lpan:LPMP_291770"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000007500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_291770"/>
    <dbReference type="eggNOG" id="ENOG502QSFS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="259843at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007824">
        <property type="entry name" value="Flagellar_rod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053120">
        <property type="entry name" value="PFR_Component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34732">
        <property type="entry name" value="69 KDA PARAFLAGELLAR ROD PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34732:SF2">
        <property type="entry name" value="73 KDA PARAFLAGELLAR ROD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05149">
        <property type="entry name" value="Flagellar_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="479"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="595" mass="69230" checksum="2A6C834CCF1D1D06" modified="2014-11-26" version="1">MMSPEDATGLEAARKQKIHNLKLKTACLENEELVQELHISDWSETQRQKLRGAHEKGEELLASVEVGTKWNLMEAYDLAKLMRVCGLEMSQRELYRPEDKPQFMDIIGVKKVLQDLRQNRNKTRVVSFTQLIDNSIAKMEKVEEELRRSQLDATQLAQVPTRTVKMMEDIMNTTQIQNALASTDDQMKTQLAQLEKTNEIQNVAMHDGEMQVAEEQVWTKVQLQERLIELLKDKFGLIGKCEEENSQFKEIYEVQKQANQETSQMKDAKRRLKQRCETDLKHIQDSIQKADLEDAEATKRYTGNKERSERAIKENEEMQEETWNRIQDLERQLQRLGTDRFDEVKRRIEEVDREEKRRVENAQFLEIAAQHKKLLELTVYNCDLAMRCTGLVEELVSEGCASVKSRYDKTNQDLAALRLEVHKEHLEYFRMLYLTLGSLIYKKEKRLEEIDRNIRLAHIQLEFCVETFDPNAKKHADMKKELYKLRQGVEEELAMLKEKQAAALDDFKESEEALDAAGIEFSHPVDENNEEVLTRRSKMVEYKSHLTKQEEVRIAAEREEIKRARLLRSGGESAAAQITSGSLRADNAANAQLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RY55</accession>
    <name>A0A088RY55_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Autophagy protein 10 (ATG10)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_312990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701681.1">
        <property type="nucleotide sequence ID" value="XM_010703379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RY55"/>
    <dbReference type="GeneID" id="22577725"/>
    <dbReference type="KEGG" id="lpan:LPMP_312990"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310038300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_312990"/>
    <dbReference type="eggNOG" id="ENOG502SBSI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270029at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO00881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="188" mass="20757" checksum="51E3DC805801CFC6" modified="2014-11-26" version="1">MKIDAAAVHCTRESFSQYAHQRCANSPWELRSKRDAFGASVEWLEATYNVDSSLDATTRTVVTTVCVLFNAEYAVPQLGFYNSTVTSLADLRVAVPNLTLVNMPSSVSLADAMGASRQPLASFSWCQELGQYMWLVHPCDTENVLRCRRYDGEQGDVLSIFLRAMSDYFPFAPLLVPRAGGNGDAART</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RY67</accession>
    <name>A0A088RY67_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_320670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO00954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701754.1">
        <property type="nucleotide sequence ID" value="XM_010703452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RY67"/>
    <dbReference type="GeneID" id="22577808"/>
    <dbReference type="KEGG" id="lpan:LPMP_320670"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320011600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_320670"/>
    <dbReference type="eggNOG" id="ENOG502S6RD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="239543at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="303" mass="33192" checksum="7EE290EF3670812E" modified="2014-11-26" version="1">MRERERRKGVGRGGSGRERGGRRERGDRTGRRERGDRSDTVLCRLHRQRRTARQMREVAVGVFECTEGSRCKQTSDRRIGAVGGRGTDDRGRFRDQRGPSFVERGAGLRQRQRRGERAPRPPQDQHYEDANAAAWAPSAGTVAGGGGATRRRAGRAERKVWCALHGKHLPVSQCEFVQDCCYVCLDPSTCLATPLEAPAMLLTRGCAEVLCSKHHTLRSAGFLELTEKPVAYQCMPGHACRGVTVPHMGQEADSAAAAAVGGPAAMPYAMADMDDDEEVYMGARVTSTFLPQSGREAVSSFFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYA8</accession>
    <name>A0A088RYA8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sphingosine-1-phosphate phosphatase, putative</fullName>
            <ecNumber evidence="11">3.1.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_322420</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the type 2 lipid phosphate phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="11"/>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701928.1">
        <property type="nucleotide sequence ID" value="XM_010703626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYA8"/>
    <dbReference type="GeneID" id="22577983"/>
    <dbReference type="KEGG" id="lpan:LPMP_322420"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320030300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_322420"/>
    <dbReference type="eggNOG" id="KOG2822">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="301434at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03388">
        <property type="entry name" value="PAP2_SPPase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF28">
        <property type="entry name" value="DIHYDROSPHINGOSINE 1-PHOSPHATE PHOSPHATASE LCB3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="300"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="10">
        <location>
            <begin position="242"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIO01128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="636" mass="70348" checksum="2CE2BA994F885B11" modified="2014-11-26" version="1">MFVTTSMPSTHFAPPASAPDFTPVASPPLPKTASMRGSTAHEGVSATVAHTGGGRNNINNGGTASGACHSRSSGAGPSPRGGGDPTGKGTASGETSPKPLSIVAEVLGREENKLPALTVSSESLDKEASQGDHTVKSAVTISTTAMPPTAVSNAVPVALRTVRENLVQWHRPLRQVAFREWYISCYCNEQQVRWIEKIQHMCDPLQPLLVRYFQLWSLTGEAEFYTLLIPTMIWLGTPLSGVKISSLLCVGQYVTGTMKDFFCCPRPPCPPLQLHGKRDTHDKEYGFPSTHSCHSGVFSFFLYCELVYVFPNHAFLCCLAAVYYFANVSFSRIYLGMHWIGDVIGGYVVAFLTIVFHIAFLDRWEAYILERTDTPWWAYVLVYVTLHLLSMAHATPRDPCPCYIDSLRFTGAIVGSTLGFWSFYSIYGTLAARPKPDHLFDVVFSFNFLLQWVVCITIVLASKELSSLTAGFVLKVVFKFVSGAYAARLPRPLQEPYLVMAKVIGLTTLGNERESQSNIPLTAHNSVRQHCSFNDDCLQDGKAATAACNRNTPSPRIDIEAAERPDGYLNSQQVWSLRTHRHWWLWDVHRRTVSYIVTGFVASFVCQVLLREGFGVGHELADHTAHYLRPLLPSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYR2</accession>
    <name>A0A088RYR2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_323870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702068.1">
        <property type="nucleotide sequence ID" value="XM_010703766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYR2"/>
    <dbReference type="GeneID" id="22578128"/>
    <dbReference type="KEGG" id="lpan:LPMP_323870"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320046000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_323870"/>
    <dbReference type="eggNOG" id="ENOG502RZ6P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276664at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO01268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="155" mass="17938" checksum="D1F1A155E11C73CE" modified="2014-11-26" version="1">MSSWLLFERFFHSPTATWCRCGLVVLGAFGVGSDYYLTHYYQAFDPSEGRQYVVDWSPIGKPRCQMLLIPNNHYTNYSPWTPKNGDIVLARDVEDEPNYLQLINGRFVERQTCGVTLLRPLEEVAQYEREEQLQREKLLSHMSSTGGTVRSPTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZ93</accession>
    <name>A0A088RZ93_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_330260</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702119.1">
        <property type="nucleotide sequence ID" value="XM_010703817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZ93"/>
    <dbReference type="GeneID" id="22578179"/>
    <dbReference type="KEGG" id="lpan:LPMP_330260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330007400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_330260"/>
    <dbReference type="eggNOG" id="KOG1311">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF147">
        <property type="entry name" value="PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="218"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIO01319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="572" mass="63468" checksum="2DC32AFB20E2F627" modified="2014-11-26" version="1">MVCCCERSWSDIVVVAALVCTTMYSAHSFYTYLFPNTLEALATAFLQPFTDVSADGLLGKSGAKNSTSGMNKRWSRVSSMSTTTLRDVKLWGWLLFLTSVFLLLMDMWAYTMAVIVPPGRVPAVFRQRATKSASLALCTFYEPLASSDASAALYPHGRTGVSTQKHGRLRTFGAHAAIEEGSSQSAHSPTDAAAPLTQAPREQFFFNPKANSYTSVQNNYLNFCPICATYKPPRTHHCSRCNCCVLKYDHHCPWLGQCVGFFNYKNYLLTLLYTWLLTAWALALLSIAIVVYVLDAKKNLFGLSPLSYAAAGASTAAPLPRTGLGVGSNIVEEFDVGPPFFGVMVCIAQCILFFAMTTYLLKRHFTYVRHNITTIDMVIYENERRLFSHGTSGDSDAEANATMSRSDVNPAAYGVRTFQSYIRRNIYDLGIQRNLLQVFGDAQLSNPGEDINGNPLPRRCYTDWMESDIPRHQHFVVRWFFRLLPTAAYPPQRTWALFDMSTHSASSSIHIAARSHARYGTVPGQAEGADAATPGREKGGSLLTELGVEEEQLLGLRFPTRSSMGLRFDEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZA4</accession>
    <name>A0A088RZA4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Guanine nucleotide-binding protein subunit beta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_323790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702061.1">
        <property type="nucleotide sequence ID" value="XM_010703759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZA4"/>
    <dbReference type="GeneID" id="22578120"/>
    <dbReference type="KEGG" id="lpan:LPMP_323790"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320044900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_323790"/>
    <dbReference type="eggNOG" id="KOG2919">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="239865at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051150">
        <property type="entry name" value="SWT21/TCAB1_mRNA_Telomere"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13211">
        <property type="entry name" value="TELOMERASE CAJAL BODY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13211:SF0">
        <property type="entry name" value="TELOMERASE CAJAL BODY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="425" mass="45740" checksum="5607BE686DD38538" modified="2014-11-26" version="1">MPPFRKGQAHVRRLYSAPDTSSELIATCDKTYVPFLAYTASTNSAVVVAEDGTTTPRVQLPFPAIDLAWCPFKKGTENAAYATACHSQPIQIWDLEDAELRASYAATNDSGCHTHAHALCWFKAPTHQHWIAGGYGGYEDATQVRVFDIMAEGSQPIWTYGDRRSKGMVSAMQDCRWQGTAPLLAVGNYNAPSVHLIDCRKRCPAAQLHGLKRGVRVIRSGMEGVDPYCVYAGGSQGDSRIACWDVRKPCVPLFTLCRPIHTQQVFEFDLLSLSPAAVSAASAAGCSRGLVSTCSTGGVLLYRWRAGEVPVEGAEVAIGASVGPTSGLAIVGPDTVVVSTGTRKYDICSVAPKARPGNLAQRSPCRDNEHGEGNSPPRVLGHRRQRSPMQDDSDEESSTAERELFSGSEATNIAVLSLAQPPTWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZB0</accession>
    <name>A0A088RZB0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_330460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702139.1">
        <property type="nucleotide sequence ID" value="XM_010703837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZB0"/>
    <dbReference type="GeneID" id="22578199"/>
    <dbReference type="KEGG" id="lpan:LPMP_330460"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330009200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_330460"/>
    <dbReference type="eggNOG" id="ENOG502RZ3Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269259at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO01339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="216" mass="25357" checksum="DF3CFE1B10659C9F" modified="2014-11-26" version="1">MLEKVVPIPFLGKEVSGWLYRTTRWMRKHPYRATSILLACVGSSILYEAQVTHRNRMPSPNVNNHLEYQLKEASLWERWLRCASTTQQGVKGTQAAALEDPGDMPVPEDVVRQQRLAQRTIADAERLLATTTDPEERQSLKEIIEHEKKLMVGVNNTTMLIRSGQLEVRAPHWEIRNNERNWSILSRDQQQQRDHYWYRLERSREDDFARNTYSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZP4</accession>
    <name>A0A088RZP4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_311600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701550.1">
        <property type="nucleotide sequence ID" value="XM_010703248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZP4"/>
    <dbReference type="GeneID" id="22577586"/>
    <dbReference type="KEGG" id="lpan:LPMP_311600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310022100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_311600"/>
    <dbReference type="eggNOG" id="ENOG502S32W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271314at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="275" mass="30665" checksum="5AA7E21CC4B2ED2F" modified="2014-11-26" version="1">MPSPPTCQYGSYHQCECYGHDTELPNYRRDISNPRTLQGYYAPNGGCPCPAKFGAEKNGLYCSARGADPSAMPKVTFRAADGPHTVHTSANVDGHGRDTATNTRTAFPNSRNYGGTVAQRGPTTLNTRPQLEASRKARAEAKREERAQERKNFLRSVLRDEMLARMDAEGKRAALEAETGLMATHHADEYEASQRVAGNIRGGLGSTSHDRDTALTLGEQYGEIMDELEYVADQPVGSKYNIIRLHYLVEEENRLNRLRWQERMRKAAEAMQSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S030</accession>
    <name>A0A088S030_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_332700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702361.1">
        <property type="nucleotide sequence ID" value="XM_010704059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S030"/>
    <dbReference type="GeneID" id="22578423"/>
    <dbReference type="KEGG" id="lpan:LPMP_332700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330034900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_332700"/>
    <dbReference type="eggNOG" id="ENOG502SHIA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267814at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO01561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="571" mass="59034" checksum="38CC2C050F364FB4" modified="2014-11-26" version="1">MRCSAAFLFSSTPPAFADTASGLPQHSSQPPPGTYHLDYESQTGLKDRAMHRVVCCPGNVSTRGCSRAPRPVTARQLCRAILGMNHADVRAAAIGKHCDCHATQEPHTHAFSSASTCIASAACGGGDEVGSDRHGLCDAVSSARLGEGTIQLDSVACHRVVVCGRIVRCVDAFSNGSVAAATGAVTSSVAPTVMPYDLLWLSDATGVVCVLRFRPALVHARTLVSAPSSLYGGWPGVSACDWRNHTLAASAGGLSDVFAADDIDGAAHPSLPPRAGVRLANGSVCHPTPEAQQCATEVYSAKVAHRAISYGMDVTAAIANFGLEHEDDCVLDVNDYVVCVGSLAFADVDVQMKHALQPYASDLRQSTWAAATSSWPLFSVCPGVATSSIGAGDDVDAMGCAECGTDGNNGTTCGKGAAASAQGCSVAVPPSRHQYVLLPSSEVPLTLDAARAELGLVGSLPSSTRYLTAAEAAQWGSTPRDCPSYDSTLSLPTAPALHDRNGGINSAVSADCGTSTPPGCAVADMNGVPLMGIKGYTRLVLDTNECLFWWLAAVETHLRLRAHASAHPIHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0F2</accession>
    <name>A0A088S0F2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_340230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702451.1">
        <property type="nucleotide sequence ID" value="XM_010704149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0F2"/>
    <dbReference type="GeneID" id="22578527"/>
    <dbReference type="KEGG" id="lpan:LPMP_340230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340007500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_340230"/>
    <dbReference type="eggNOG" id="ENOG502RZHD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271968at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO01651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="718" mass="75157" checksum="79FA142DE8449D00" modified="2014-11-26" version="1">MSTSTRRISVTSEQLQSDALRAQLFSACCAYGVVEWAQYEEDPNYNTTTVHIQFQKLSSAERLRSDVQQRGRIWQIESKQAVLCVGADVLLSSADLLRLGRLTAALPNFACTALPSVPVSSTSTTVTTASESPSPTFEEKSFLLHGRSTAPCPTPASSKATAEQEAALWSGFDKESSAVRHSCLGPYCAVLHFRSPHDANEFLCHHQLTLADQHSVYAIHVGTAPGCALAVSLPKMLSRHALADCAVEGRVVRGYVVAMPSNTYCVVDAGLYPAADQANVTTLVYSHTNFLSVSLGDEVQVQLSAVGGLSVAGEGMVGGKLLRVTSVSAFSTRRSVAKAQLPTTTARTLRTSNVARSLAGALSTTPHQPQARPCSGGNAISVAGAERRGTLHNKRNAAAAGGGNGSAVTSKPVGGASAKALASKIFKGIQQRGCSGGAAVGGSAERICAYPAGLGAYARLLVRVERIEGDGLHARCVEDAENCGYTGPVFIPAELVPADTSSTGQGWRTFAVVGERMHVALLYMVAVGGSAATMRAIASKKEADLRHTATIAAVTAMGATPEDLEGTSVTAGTTMTAVAMLKLSPGDLGVPAASPTSPYFPAFLLRPGLHASALLRQTVLLLPLSDLGTLDPTTLLTSPASLIVSEVVNDVMRGQYAVVLPCAVYAERQTQRAVAQEQRKAAEVEEVKHRLAAVMGQDILKVLNAEDEPTAKRPRAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0N1</accession>
    <name>A0A088S0N1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_341200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702546.1">
        <property type="nucleotide sequence ID" value="XM_010704244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0N1"/>
    <dbReference type="GeneID" id="22578625"/>
    <dbReference type="KEGG" id="lpan:LPMP_341200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340018000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_341200"/>
    <dbReference type="eggNOG" id="KOG0191">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="74910at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815:SF3">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839208" evidence="2">
        <location>
            <begin position="30"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="521"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="51"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO01746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="564" mass="63669" checksum="71FDB8B6003074C2" modified="2014-11-26" version="1">MNPAMHCAPWRTLLLVLVILSATLCLSHAWAAAEDVNEHTSETLELIFEGSTTTYKLPDSIVVLNNANFEPYLFPSKHATPRAFLVLCYSPWCSHCKALLPQFLNASLQLDLMRVPHSTFAVVDVQKNTAVSEYFNVERFPTLLYTTGKDRQWHLYEGSNTQEGFMQFSAYLQHAVDNGSFSEDVTDVVRFNEIEESSGTTRVPCYVYVPATSISTPENQRTASWSHAVDGAASVSNIRFAVIYEKSQAEGWVEHAGEKYKKVVEKAKACVAAGKAGGPEGEALVVFSDRYRAPRCYSGPWVEKRSVAKTSKSRTGQATGDTMAMSTSLENFLALHGFHAVEDASSAMFATLEHYPKNYLGVVMTNRPINDKDTEYVPVLREIAQAANDALEKEHGRDLSIEEEMRIPRVSWSYIDVVEYEMWRSRYDVELDQLPAVMIIDTKRDRFFKMRTHVPRFEAIKLNTPWRVGGEQHQLIAQFAQDVLADVYKAQKLSVAGAVAEYLSHYPGFAFLYETLNYEDFVFDVVVMALGFFSFLLFLGLVMEPLMEWHDGRSKKAAHKAKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0U4</accession>
    <name>A0A088S0U4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain dehydrogenase/reductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_342000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702626.1">
        <property type="nucleotide sequence ID" value="XM_010704324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0U4"/>
    <dbReference type="GeneID" id="22578705"/>
    <dbReference type="KEGG" id="lpan:LPMP_342000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340026200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_342000"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF284">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="440" mass="48501" checksum="A6E89A126847B750" modified="2014-11-26" version="1">MKFGYKSESNAFFLGAATVAVCLFIPRRYLAAAIPLWILASRLVARGAMNHARPVTDADTADRQAQSRFVLSHDMPLTKRPVAIVTGTNSGIGYWTAVGLAVEGYEVVVTCRSAVLTQQTAERIRQEAERCRNAHPQRYAHSPASILVEGHLPLECEDFDSARTLAEWVTKKYAKRNVQVLVNNAGGMRKELTFSQYHPNLELHTAMNFLGPLLLTELLLPVLEKNGGRVVYVASEAHRFPQTLLLSSSFSAWKTVKAFPKCNCLIGGKLLNALKEVNQGAGKSSGPLQASSTRQAFVRYGTSKLLNTYHAHVIARRYRDVKDEAHRVYACSLHPGCVATNFSRDILSSFVNSIFAWMSLLFLKTAEEGAQTSLHCAMCPREELELVSPSGEKPTSSADAVSPYFVECADQTTSMLRAYGWDVSEAEAILQWGRQQVGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S188</accession>
    <name>A0A088S188_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GTP-binding protein, putative</fullName>
            <ecNumber evidence="5">6.1.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_345140</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.1.1.3" evidence="5"/>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702933.1">
        <property type="nucleotide sequence ID" value="XM_010704631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S188"/>
    <dbReference type="GeneID" id="22579019"/>
    <dbReference type="KEGG" id="lpan:LPMP_345140"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340059600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_345140"/>
    <dbReference type="eggNOG" id="KOG1486">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1708588at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001436">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000003">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="65"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="294"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO02133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="374" mass="42257" checksum="9E9AB52F5CF1BAE5" modified="2014-11-26" version="1">MGLLERRRAIEDEIARTQKNKKTEYHIGRLKGQLARIKTEMMENAARAASARGGDGFDVRKSGDVRCALVGFPSVGKSSFLSRVTQTESEAAGYEFTTLTCIPGKLMHKGTEIQILDLPGIIEGAAEGKGRGRQVIATARTADMIILILDATKAEPQRFKIESELESVGIRLNQCFPNVTFKKKASCSMNVVSYSSTMPQTKGLSEQMVKEVLKDYGIFNADVALREDITVDQFIDVIEGNRKYMPCLYVYNKIDMITMEEMDRLSRLPHSVVLSLLWDLNVDEVIDEVWEHLNIIRIYTKKHGEHPDFGKPFVVKRDANVEHICKRIHKDIASRFKYALVWGTSAKHQPQRVGIAHELEDEDVLQIMLRTANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S195</accession>
    <name>A0A088S195_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cleavage stimulation factor 50 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_330320</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702125.1">
        <property type="nucleotide sequence ID" value="XM_010703823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S195"/>
    <dbReference type="GeneID" id="22578185"/>
    <dbReference type="KEGG" id="lpan:LPMP_330320"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000013100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_330320"/>
    <dbReference type="eggNOG" id="KOG0640">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="14421at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005848">
        <property type="term" value="C:mRNA cleavage stimulating factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001781">
        <property type="entry name" value="WD domain, G-beta repeat, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044633">
        <property type="entry name" value="CstF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44133">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44133:SF2">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="331"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="382"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="300"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIO01325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="511" mass="55690" checksum="FAB6F5633A94061D" modified="2014-11-26" version="1">MAGGAQPHRKRPRQGVLVDPLSREIYQMVVRQLHHDGFLAAASAVCDATGVVVGNVEDQGDRLARVVAAGLSVNEMERRAEEEFHSTQVVERFLSASKLYMPLSLSSRWSVGRRCLRMRERFMSASLGGVVRDISFSPDGAYVTCAGTNGLAAIFSLETIEDLSALDEARAANRARALDGSRDAGSFANGETAPKGSALRNANEVTELAMVRRFHEHTQSVEVMRFHPTKPIVLSGGRDGNLYLRNYAYPDSRVVLKIHDTVPIRDASFHPSGEYIVLAANHHLPRLINVQTEKVLTPPGTYASSTAHTGPQWEAEESGTATTSYRPSDRGAQHSAALSSVCFSPDGRTMISTSLDGTWMLYDGVSGRVIYRAENAHSGVPVTSVVYSRTGNVALTAGMDSTARLWDLRRLHATSRNYQSPEVTSFGEPTKCDHRSIRAVFSANEGHVHCHDSTLLAVHSYCVYTGVVTSTVTTQPSFMQRGLAASPWANCIVTGGDDSRLRMWTPAWLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S206</accession>
    <name>A0A088S206_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="6">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">MKK5</name>
        <name evidence="13" type="ORF">LPMP_350890</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="6"/>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703026.1">
        <property type="nucleotide sequence ID" value="XM_010704724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S206"/>
    <dbReference type="GeneID" id="22579118"/>
    <dbReference type="KEGG" id="lpan:LPMP_350890"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350014600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_350890"/>
    <dbReference type="eggNOG" id="KOG0581">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06623">
        <property type="entry name" value="PKc_MAPKK_plant_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000744">
        <property type="entry name" value="Putative mitogen activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF9">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="59"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIO02226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="526" mass="56568" checksum="3ACA6185BFAEF1FE" modified="2014-11-26" version="1">MSRLKINLEAIERDGASVTEGFCADGVRIGSLLVSSEGVRDSQGNSYVLSLSDLEVVPETEGGFLGKGSSGSVRRAVHRRSKMVAALKEIKVTGQAHISEIRRELEALHACDFATPYLVHFYGAFAHEGSVFIAMEAMDGSLDELYKPVPPPVLACITRLMLKGLAYLHRTRHLIHRDLKPSNVLYNSCTGDIKISDFGVSSNLESTKADAHSFVGTVTYMSPERLRGEYYSYGADIWSLGLVVAELAVGVCPYAGLRGGSSEARFWALLQHLSSDGPALELPPEMDADLADFISACVVKSPDRRPTCTDLLRHAFIVKHASSTPVSEAKQCWTTTPTVPAPGELLPPLNSHSPAVGSVAPLACEGATLRASSSCPAASPPSTMLPSPLERYDGETDADVADRTVIARWIHAMMKQEAFRRTKENGYEVSHLEPLADVSVSTAIDSNEGGRTVGAPALTLDRSRASALRELPAGRSRDRHSDDSGSASIAHECTTGGHPLICNDVRRTATVESSVNLDDELNKLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2S6</accession>
    <name>A0A088S2S6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glycosyl hydrolase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_354210</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycan metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703354.1">
        <property type="nucleotide sequence ID" value="XM_010705052.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22579449"/>
    <dbReference type="KEGG" id="lpan:LPMP_354210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350050200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_354210"/>
    <dbReference type="eggNOG" id="KOG1066">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3237269at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090599">
        <property type="term" value="F:alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF54">
        <property type="entry name" value="BCDNA.GH04962"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="9">
        <location>
            <begin position="552"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="876"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1298"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="876"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIO02554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1467" mass="156495" checksum="52036E560D518F1D" modified="2014-11-26" version="1">MAKHSFGFRGVRNRRSRHLLLRSALALAVLVTLSLIALLWFFAYESREGVEIPGERHFSPLTQHMADEEVDADGTIPFRRPSSVTSTTCAPVAESSSGVGAVWFNPKTGDASHPNTSWLHSAFTSAGKVRVALPFGAHADTGAFVSQKPRLFAFLASWRAYERMLMGRGSQGDEATAAADVDEELPVFARRRVAPVKHVEVRLLRQRSSRNTWAAPTETMLPIVGILPRESTTLVSAEELLVESALSKEGLEPLVAAIQPGSDNKESTVVGIDTRLRASAAKERGGNASHSTGDGTSLLPFPLLELSIAPRRSATSPASSTAVNSDVIPATTLVKWRTGHMTAPASGEALEITLDIVHPSRPSLDASLYTEESEKTRSGARGDPYTSTLEANVCSTHIVRLYGLSPSILSVHTHGGSAGASAVAEEGGLNVIPLNMSEEVELMVGGETRLSSGGARLSGVVPLLYLELSYGRTADVQQGAAAGEHQTMGLLWLHPGSFFISTLTSPTPTGGHVPPRTCVRLRGTAGATGLYLLPGPTPAEVLRQYYTLTGFPTLPPRFLLGYHHGLQGADVTTQQAAEDLSEAFRNAGVPLDSVWMTNSAVAAGDTPFTWNHTRFPDPLLMQSNLWYGGRRYVISRSVPTVPITSRSPLLLEGRRGGLFVSLSAVDTAGWPALSVDGVSSHVVDFFSPAASKWYSGMLKYRRYVGSSNHTFISLHHSAPIVRASSVPTAGEEAFLCLPPGLRVEGEVLPMNVGHHGGVQHNQVHQLLTVHFARATHEGMLRRTHYHRRALTFTESYFVGTQRYAVVRVETQPRCADTVPPDPASILREAWGALQTAVRQCAQLGVIGIPFSGANLAGGLSSRLLLLLLQLANAPSTAATPTTPVPGVAGSGDGGAAAEKNGELTVSSASPRGAMEEMEQLLVRWYAAGVYFGAMYTDESAVAADTTNTGGAASLQPLATGPWWMRLPVAAATRQAIHANIYARYALLPYLYTAAYHASEEGSIFLAPLAFTSSEVSPPSKDMSTPTCYTAGSALIVCPVTQPVHPLRDVRESDGPRSVVGTGFFDLWTGVWHGSVSSAAGRASWWERAAQNGGPTSKELAWLATNNVDPLQVLPVAASLAPVLLRSGHIVATQNVIVSRASSAHVSDEAIVDTRAVHSTHMGANWTITVALPSLPVAGSVAAASPVTLAEGDVFWDEGSHNGQHQPPTMKPGDSVPPYMPYIPPNVHHCALHMKCLYEDAGASAATAQLTVEVTQTSESCAEALAELVSHWNEAPQGFEERLASAKAHRDSRLHQLEVEQNAQEDKGLRGDRGGVKDFPEASTLTREDLRGLRLPNAHDEATRNALWSSHILQRLRFLFQSEEDAARLSRKSSTSSATAIVVVERHSSTGNTPGVQAGEEGAVRASVCASHDVPDAHAVLVHLVCDVHGEGIAASVFGARKTVLADGSFGARVPPRHTWSFSFSLMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2S7</accession>
    <name>A0A088S2S7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_355330</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat WDR6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703463.1">
        <property type="nucleotide sequence ID" value="XM_010705161.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22579561"/>
    <dbReference type="KEGG" id="lpan:LPMP_355330"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350062000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_355330"/>
    <dbReference type="eggNOG" id="ENOG502S33R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272652at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051973">
        <property type="entry name" value="tRNA_Anticodon_Mtase-Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14344">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14344:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1139"/>
            <end position="1167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO02663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1457" mass="153708" checksum="183746C4B7186E29" modified="2014-11-26" version="1">MLCDVCDAPITAIACPSNRDEVYFAVGNTVHCSRTASLECSTSVNSPRVTSATVHIATAPPGTTISAMDVAYPSSQLPIVLMGAADRVLARCGAVSDPSRRPCSVVLHADEGRVLRIVVDERRGVVCVATASNDLFYGALDRIAQALHAQTTSSHHDVSACCAFSRVSGPRLGVVLAADCQVQHPLLAERYEGLIASVAKGMSCVSCRIFSATYAGEVVEWEAAEHDDCARVPGTALRQPSREWAGSCSVVSRVQAHPSGCAIFAVRANTTYPMSCGTGSTQGDATALARTHLVSCSDDRSVVLYERRFLIASNGNHLEGHAEPQESDWVLLWRGSGGSFARSRIFDVALHSTWRLSVSKDPEQPWCSCAVYVGVAGEDGSVQVIEVNPSDNGNLVALSLNNVTQGASMQAVATPRLLRCHQHRGHGVYRVAFSTPSPDSVTLISGGFDGAVFAHMLPFALQREKDGEGGAVQLRTHEVMLQPPIVPTATICGNVATDREEVLRPHSSFSSSAKKTDQVRAVHVDSNGFLLACTGRALCVLCAHSPLHSWWIALLPDASRERYKAVGDEPALDWGFPATLESVIAQCCVPSARRENLASIGCALVGTTVGVLRAVPYCYYNAELGVSLPVAALAAAPTRRPEDELLATLALQTFGKITQVSALHVPEGSVSAVPHALSGDSDAVAHSSSDTIKSEFIVATNHVRNTIVLSRMLLAVCHAGSSGGDASTGERSVELCVSAAWHILVVYSDCPGPLTTTLSLLPIPCGLCSMSRLSNESCCSVTGNVVLSLWLLAGDKNGCLLGTRYDVLTCSLEAVSNSLDSHALPPATSLKVVATVHRYVFAEHLHIAISAVCAEICSSAPTGDGVREPGATLITVGGTGGVVEYVYLHASSSSSVGEAVKGSPLPSPAREPLRLPFEVSDVLSVSPCLWVVQCGTTVSFLHRVPGHASWVPVGSCDGVRAPRLLTARIVASSPTGSPIAFFAHCSDGRTVQQILVRPDPTALLPSKLPVFGAQTALLHGVGFPGKDYNCVAYAPAPLHCLLMGNEDSSLALYPIRAARAAMGMPHADSLFGGVLTPLNVCGAHHSNILAVTVLPGTEADVLRFVSVGGGAMVNLWSAGRIFSPLQLLDWWCGSGTPPLHNTTSSPPDGASSADVKGDSVSREPCISSTRFQRRRRKRVVAASASLTLTERNPRFMAVTALSSTEIAVGSSDGTVLLFHVHEDRGAKGRAPQATGATLELRWQGVLNTHRTKPVMCMSSAHDGGCDSLTCSSNADLALPLVMAGDTNGVVYAIDAASHIVRAHARVEQSSVNAISELQRIQKVLPPHAEATTHHWRFAALHDSGVVHLMTLEVAIAQGEGVQAAELQRLWSASTGLTAGRSVHWPALSMPLIVVTEELIIEFDPEAAQRGELRHVHAQRVSVRGVSGAAVVNQTSRNQPLPIRSRVAVVGQGFELVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2W7</accession>
    <name>A0A088S2W7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_355780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703508.1">
        <property type="nucleotide sequence ID" value="XM_010705206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2W7"/>
    <dbReference type="GeneID" id="22579606"/>
    <dbReference type="KEGG" id="lpan:LPMP_355780"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350066300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_355780"/>
    <dbReference type="eggNOG" id="ENOG502RYR3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="79090at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000245">
        <property type="entry name" value="Hypothetical_protein_-_conserved"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="401"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="490" mass="54201" checksum="811CC39FF37B3447" modified="2014-11-26" version="1">MTDAAARDAYTAYGVDLIRTAGLLLRTTPSTIYRASILFQRFEASVETHFRSQYIGALDMPAYRNCLSEDLKRAQLELLAASSSSSNPSMTDKTGDASSKHAHPVGVEYLVPNHVQLKMRTGLVPLVDLHAPLDYCIHHLSDQDDIMYLVAACLLIATKMEDPSIRIRAVVNVCMRLSLRRSGTPVNDQVKPSLLRYEDFKACVVEAEEAVLHQLGFQTFVESPYKYVLLYLNLLLEPASEETHSDISGDGSTAVNGATRPSVATVAKVARPPAALTQWMIRAVQVVNDLPRCRRLLAVPADALAIYAIQQSCPSDLTLPDKWSRAFGVSERLLKAISYRYGVYSSSSVGSRRATAALADARAFSTVPLYRTVAECDQYNLAMKQLKVAREATTEASAKDAFSVSPAPSPSSSDSAGQLPASFASPASIEELRNLIDASFPSDDIHDTSRRRPRQSDDENILVRKSKHGKRHHRRHNDTRESRKRRHHHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S354</accession>
    <name>A0A088S354_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_343980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702820.1">
        <property type="nucleotide sequence ID" value="XM_010704518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S354"/>
    <dbReference type="GeneID" id="22578903"/>
    <dbReference type="KEGG" id="lpan:LPMP_343980"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340047100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_343980"/>
    <dbReference type="eggNOG" id="ENOG502RU9W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276532at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO02020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="422" mass="48582" checksum="1EFE38FE0558A5A7" modified="2014-11-26" version="1">MKDTMATFGVDMHNVSADEDPPYVQEHQRQRMVQNVMSSSQNLRSMSKMDRLRLALDQVRNEPAGHEKWNEVYLFLRTTEMCTEVLTNGSDMFPKGKKLWIEMELCEEKRVPVLMVLPNGMPVLPIFTMEEYMDSYFSRTNVYDSCWFPVPRSGTQWEEFCKLPFPVCVTGNIQHFSTLATVALGNHQLGILVNPGMRSSKFITYPEMVTLTQLRQQRRKHHQLAVTQSTTADGRAAAAAGKERLFDSNLMMTFDTTRILLRRLEPQDLDGCMAQRPPIPPVAQLELHLLLHVYPEIESVYIRTVDRPRWRRMLGAPEMMTQIDVVCNPARKPDASFVEHLQQWSFMKEFNSDVHVELTSRAPVQEGSTGAFMCVYSNEVDGKPLRAMTTFKGRTLADQLNFNEPITDSEGNKPYERYVSYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3W0</accession>
    <name>A0A088S3W0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mannosyltransferase</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">GPI10</name>
        <name evidence="9" type="ORF">LPMP_351230</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Endoplasmic reticulum membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02260.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703060.1">
        <property type="nucleotide sequence ID" value="XM_010704758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3W0"/>
    <dbReference type="GeneID" id="22579152"/>
    <dbReference type="KEGG" id="lpan:LPMP_351230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350017900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_351230"/>
    <dbReference type="eggNOG" id="KOG1771">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416834at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF4">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 8 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIO02260.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="622" mass="70171" checksum="A10E1700A4E3F4FD" modified="2026-01-28" version="2">MDVLTVFSLWPRPLRSWRVLAVLLLYRIALCLTLRTAESPDEWWQSEEVAYHMVFGHGHLTWEWHESIRSYAFPAIFACPLFVLKWTGTDTAMTVWAANRCVQAVIFFAQDCTMLALAQRLDDLRCGLDLSTSGRGAGSFSPSSAPSSSTKTAGGIPTIASTTLAMLVVEWFLNNTGVRGYSNVAESLFFLLSLYQARYSTFLLCAGAACAVRATAAIAVLPVFMVHIFRLCRRKGIARGLAVLAPLTVSALASVSAAVCLVDYVFYDRLVFTPYKFLKVNVLMGVSKYFGVHPPYWYLVVLPVMAAPFVFFLAWAPVCWKRMQVAEGHHVSGSTRYADHTLLTCTSSRTLRQEIKRWVFVGVLSLMLYSLVDHKEMRFVYFLLPILLVLSSVVVVDLCTSSLSAQKNSSSVQSVRWSLVVPSAATARRLFTLCWVANVALTIVLLYGYRRGSPTLWRKIRDADWHFRHLEVLTHCYATPGFAQLHGKVDRLELVDCPVKLDPVLGVREVTHDLLFREQQKAYALWRYLRLPSKLDVEEVGMESEKKLSKGAWWRGAHHLMPAAEPPVLPDGIVLFQNTAISLEADLLRPMGYRLIAVVFHTPYSFEQDEDRYLELWSREVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S453</accession>
    <name>A0A088S453_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acid phosphatase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_352530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703190.1">
        <property type="nucleotide sequence ID" value="XM_010704888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S453"/>
    <dbReference type="GeneID" id="22579282"/>
    <dbReference type="KEGG" id="lpan:LPMP_352530"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350031900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_352530"/>
    <dbReference type="eggNOG" id="ENOG502QWMV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="258392at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF137">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013017426" evidence="2">
        <location>
            <begin position="16"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO02390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="406" mass="45756" checksum="A340A8C3C720BFF5" modified="2014-11-26" version="1">MCVTALVSVFGLGSAGPNEHSAGPDPIDAAHPRLDINWTEQSVNSHKTKAERNEILESKLVLTKLVVLNRHGHRAPNAPFWKMCPNDIKSKKRYDVGAEDLTGLGMEEEYNFGQFLRDTYRDFIGNKFNRTLHYLRAVGEPRILQSAMAVAQGIFPDGFGPGGYLPSRPQFVPIFSDMDTHEYLLDNVPCFRRAENDSHQWVDKHFKDFINDPSTSRVLSMIKKVCGEYTGKAGAYAYIKTVADGLTFNSDFGLKVAKGKLAPKMLLSIRNVSLQLLMQRLYGTDEQQTYMAADLPRSILQTLSHTHLGETPEQLNDFTDTRQESTFYFMHREALYPLAQFFGFQCSVPGLPPGEVPVATSIIMEKLALHRDQDSHNASTYVRMTLWTPYNGIYTIPIPTCRIPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S6K3</accession>
    <name>A0A088S6K3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Kinesin, putative</fullName>
            <ecNumber evidence="11">5.6.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_171080</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Ungrouped subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.3" evidence="11"/>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697799.1">
        <property type="nucleotide sequence ID" value="XM_010699497.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22573851"/>
    <dbReference type="KEGG" id="lpan:LPMP_171080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170017100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_171080"/>
    <dbReference type="eggNOG" id="KOG0240">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270747at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000874">
        <property type="entry name" value="Kinesin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.380:FF:000023">
        <property type="entry name" value="Kinesin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000123">
        <property type="entry name" value="Putative kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022682">
        <property type="entry name" value="Calpain_domain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022683">
        <property type="entry name" value="Calpain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01067">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00720">
        <property type="entry name" value="calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="10">
        <location>
            <begin position="8"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1179"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1253"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1333"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1214"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1179"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1265"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1333"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="93"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN97146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1433" mass="158533" checksum="3C5C4CFCEBF523DF" modified="2014-11-26" version="1">MSKAVVSRPRVYVRIRPLNEREVREGKGELACRGDARQPDVLFLKKDETLEQQVRFDQVFDHCSNQQLVFDQIGLEILRTLFSGYNASVFAYGQTGSGKTYTMEGDKGGGMSGGASSEEQEGLMPRIIRGIFSSFGSNANITDALVEVSLVQIYQERIQDLLNHRKQVEIHMDRTSQYIARDATWRTVRSLEECMKLYGEASRMRATSATEMNLVSSRSHMILMLRMQWDEPTLPGSHAQLNMIDLAGSERLNESGATGETMKETITINKSLSALGNVVGKLVEQAKRPNKRMHIPYKDSKLTYLLQSSLGGANLVHFVLAVSGSAMWRSETASTIEFGKRALQLVLRPVRNAIDYTRLAEMEAVIERMRSHIESLEEELQLKRNSEAAGFLQLRQIAQSDDEAMQRQRRWKDKSANHKHLKRQTELTRIMANLPETFDDLTSHCILFPESKVTFRELGGLEKLIHFVERSASNYYRASAAQTVASVIDEPGREVFASLGGLDALAMLLCVQEERCKEAACVALEAVCRGCMTNKTSLSADVYAELVDLVYGYSNQQVQEAACAAIASIVDGYPEATRRFEKLDVVPKLLETIRTCPAEVVNLTKAATNCIGRLAHGDREMLQTIASLGGVDLLIDVLFSSSGDRDHQVPILASYALVNLCCSSDENLKVAMGHERYGEVKFRLLEGLARAFGTNASREGFGRATAQETAGPFPYYGVTIQDEWTYASSGGRPIFSTFMDNPQFYLYVRVETDIAFIIQDTLYEARLRKKRRNNSVYMGMAIFEGDPTLAKLGLKQLDFHGQMIEIGHYTSNCENVLHCTLPASDTPYMVVPFTSQKGRHTHFALSAFGNHPIELTSVPDQVGWVHTVLLGKWTEFTGHGGESFDWRCNPQIKLKPKEACRVVFVLSYLSLDEQRAQLRQEEEEEEWQNTRPRLHGRLFSNAFAADKRYLKAIVPLPQGSTFVASNTFASNSYITTSATLDKNGDYVYIPFTEAPYQDTYRVSVYCDSDEVEIKPMQGQASEWMCASLSGTWQGKPISVDLDTTGKMVVVMYSPGAFVRPRLLSAATQKRIAGIDSYWNTEAAVEYDSKGKLTVQVEAMMRSGALNAAGTRGTIEPGSSPTTQVLAKDIRFDLFIFTNTKCTLTQVSFDASPSSWPCPTQSTSLGLLAYPQLVEDVDAIDGVDGDDEDNSDDLASENSYGERNGISAAAREARETELLKSLEKQEAENRLLQRQLAQQACELEALRNSGVSVVTPTNCDRRRGSSAKSSGSKAPKGVSSAMVDNYATLPEGNQRSGKEASGGGSARVALQAVGRNTARGSIASPVDAKRAFTKTLSTGPAQQGSDVTRRRPMAPAGAASPMNRSGTADNMAPAAPLPQVKESVEYTLMKLREMSKRATTHARLAGNKEDTVWRAILEDIGEVQQRLLKAFHML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S7Q4</accession>
    <name>A0A088S7Q4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_201270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698328.1">
        <property type="nucleotide sequence ID" value="XM_010700026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S7Q4"/>
    <dbReference type="GeneID" id="22574336"/>
    <dbReference type="KEGG" id="lpan:LPMP_201270"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201270"/>
    <dbReference type="eggNOG" id="ENOG502S9M7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267176at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="284"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="561" mass="60641" checksum="91CE41187EBBC67F" modified="2014-11-26" version="1">MRPSVFTSAKGPPLCSTTVLRPPLTTPQCTAAGYSTIRLDTYHDTSDLREALRKIEAAFMCVEQEAAGVVKPAAEVMSSTADPSTGNGAIKGTADVQLERSDRRALSVSTILFKKNAATASMPPRRGLPVVLQLSPQLVIYCFSFCNLQTLSVLCRVSVRMNVLLTRQGDALWLAAAQRRRIPIEVPACAREELRKVLLRRARERNAEEAHYEAEIARMEQRLSARAQEIYAQNVDVDFALRTSGAVSTQVAANTESFGLRQQRIPQAMAGAGVDFAGTTPAAVSQSAEMYAKLQTEIEALEEMKRACECRLNLQEELLLRQDAQLLQWQSLLLPCKLPKSYSPLAPAEGGAATAPIQTEKESADAAASLPALVSAAQVDNFERRIARLVLNGPVATSSAAITDESPGESSLPVVLRRGVENFASLELVLRAVGNGVPVTGSSPANADAVLASNAKATATAAASDTAVRAAVRRWNAYKKICPTNEEYQKARLFLKAQVLRTVPGPMARVQCNTDGHCSAKADAQLQQQPSVREMPALIRLSGFVRRVEAMSDAQVLQEWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S9P8</accession>
    <name>A0A088S9P8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_220670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699068.1">
        <property type="nucleotide sequence ID" value="XM_010700766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S9P8"/>
    <dbReference type="GeneID" id="22575113"/>
    <dbReference type="KEGG" id="lpan:LPMP_220670"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000049300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_220670"/>
    <dbReference type="eggNOG" id="ENOG502S669">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269016at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="120" mass="13789" checksum="904C5D26BF51B7BA" modified="2014-11-26" version="1">MLQATLVTRLFSKPIAQGYVAQLPRPLPGSKGRSWMRAMDANSDVRDFYTADEERYNAWYRETYGIEDLSDGSAASGAASNRLLDDTRNMQQAAEEYDLQGMREELEFWGDEFQHITQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S9X9</accession>
    <name>A0A088S9X9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Abnormal spindle-like microcephaly-associated protein ASH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_221520</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699153.1">
        <property type="nucleotide sequence ID" value="XM_010700851.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22575198"/>
    <dbReference type="KEGG" id="lpan:LPMP_221520"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220018800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_221520"/>
    <dbReference type="eggNOG" id="ENOG502QQ4Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10060824at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056343">
        <property type="entry name" value="CFAP47_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053879">
        <property type="entry name" value="HYDIN_VesB_CFA65-like_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058952">
        <property type="entry name" value="Ig_CFAP47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45912">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45912:SF3">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24529">
        <property type="entry name" value="CFAP47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22544">
        <property type="entry name" value="HYDIN_VesB_CFA65-like_Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26579">
        <property type="entry name" value="Ig_CFAP47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HYDIN/VesB/CFA65-like Ig-like" evidence="7">
        <location>
            <begin position="392"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Cilia- and flagella-associated protein 47" evidence="8">
        <location>
            <begin position="1367"/>
            <end position="1575"/>
        </location>
    </feature>
    <feature type="domain" description="CFAP47-like immunoglobulin-like" evidence="9">
        <location>
            <begin position="2577"/>
            <end position="2684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF26579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN98446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2797" mass="302970" checksum="A98062ACCE0C7CB7" modified="2014-11-26" version="1">MPAFSVHMQRDPSRGARGISDTKKSLQSFLPASLNRPAAASPPKPRMEVTPPAAEFTNYDVDTAYVMPLEVRNRTGEILTLRFVKPARHPGTFRLVNGASVRVAPGLAHTVEVEFTTHAPKDYADVLVILSSDGGCVEVPLTACRVPLIEFPSTVSFGKVEQQLVCPMRTLTLVNRGRKDAAVTFVLDEKEEKGCDVTCGVALSSTDVTVPAESRTYVTLELKPLPPGLYTWHIPVEMNGQRLPHLLEVTAEVVDCRSRLFDPQTHKEVVSVEFAETFAGNKASHPLEVVNGGSQAISFAIRSAHDISEGGVMPFRFVPTQGRLPPQGRLTVTALFTPQLKVRRTGWSATPSNALTETAEVRKYEALFSLLFVETEQTQTFRMVGTSCETLVRLSTSVIDFGTCVLKGLRESTLTVTNGVAHLPMRYALKCPPHFSVTPARGVVAGGGSATLRLAFRPRRLEPYVEVLTLTANNTVTCTVELRGTPLYREGAAAPATARSSGAEDEVAVPVAVDLGMIPAEGLTPPSLPRQVPAVVLIAEDTAMRSCRSGHVAPPVFDVYSLAKRRFHVTPTTSQERRDCKRELTPMEVLNVVLPSKSLDFGRVTIHADAVASLFVYNGTNASIQVSVPTEAEGPVTVEPVSQVVPARRMAQFDVHLRFGAIQSFQQVMRVTVNQQHYMRFSVLADVVPVEVTLSQTQVLLSLTGQAEEPVCTAQVALTNKGNCAAAYRWYLSSPSCEFEVEPQMGLLNAGEQRSATFYFLPAPGTSKASCEARLEVVGATEDKVLLLTGSVAPAKCVWGTSATFTSLPVAPGFKEAAAVSGVVALGRIAAGVPALAVLPITNKGSTNAYFSVGALPAWLSVSPSQGRVCAGETEELTVRVRHAVAGAVVHLVECNVAGMRRPLVARVEATVVAPSLSVELDGKEQGETHLDFGHVYVGCPQSRSVTLRNGGDVAAAVRVNLEACTYYSLDSAVLEEEGQQDILESRLSLSAMGEAQRSRLMPRMRSLRSLSVADRKLSFGVAAATVVVPPLAEYTLHLSFNPLRAAATQHCSVRWHQLGADDVHPLPPFTLEATALAPPVVLSATTVSFPGVVVGQRPPPQVVFVRHGDLSMPPSLPERRPVVWRLEMEDSTPSFLVEPHRGVLGVGEEHAVTITYLPMSAEQVQTYVLLKTEGAESPTGAPCARCAISASATDPRVRSDRTSLVFPAVPLGVAVETTVLLHNEGYDAVRVEYLGSCDPPLQVSFPDGHSMGAALRSTLPVTFTFCSPAPISVRSAIRLHTDAGGCIDIAISGSAVNSIISTEAFVSYMSLVTPTTITAGAADEGDDASYVLQCWASDHESVLMAKLPMVCTLPSAMDGTHGCSHDLVDAVEESIDWEAERAWLTAWWNAFVCRTPVQNLVEALQTTRGGIAGDMTYQFTGKRPRRAEALESSLTASTRVGKGGNAGPAATATIRSRKGTVTAHGGTRRQRALEVANTPLSSSASTIPKELRTLHTLIQYVRSCGGCLRDVELPFLLPFDAFLEHTAAHSSSALERLSGVAEDEDLELVFERRATALWVAVMRECLRLFYVSQVRVTSATSAPPALLGWLSSSLSQRSLSRSNIYSEEESLLLRWVTACVETFANGDNADLHNRLSAALPRCFEDLRDGQALIIVVLTYVPFLGRQVREAIVSAEQQSCEAHAAVLLDLLHTLRIPGLPLADAFVAAPPTQVVLLLTHLFVYLPKFINTVPVSFHGRALTALTETVTVENTSSQPHEYCVLLPDAPLFRANTDKLTVAPRSSAELTLSIIPRTRRPVTGQCLLVDCSSQVPPAERVPFVFQLKATPTMEPLQTVYMETPQYECLQSELHITNPFSVDCVVSLRVAQTRLPTATQKTDAGATPEVAAPWLDSDDASFWRHNHDAPFTVATEVLSLRRGEPTRLPFSFAPLSRGVYRLLLTFWEEWEGEFTWAVEATSGWPKPVDSNLELRVELGESCTSILDVKSSNPSLERCVKLYEDRAHNTQRTDLSRLLSGARYVVHFVNERMEGPNPFFATSEGSCLAPTTPAATWPVTFTFKPQCVGVYRTYVLLMSEADVRLLLVVGECVPRGDRRTLQFACPARQIILQQITLCNHSAAEDWLFAATFEGSAQFSGPHDVRVPSGRSKEYTIKYAPSWISEEETATLVLLNGITGQMHTYTLVGTAGAPLSEGILTLNCRARDHETLEMMVPNICSQDTTYFVKTDLMCCEGESSSLVIPRASSRRFALEATPNIGGDYSGHVTFTASNGRYVWYAVQLHVAPPEKEGLIELRTNVRALMVANVSVTNPLDTALMFKVHRYGAGLYGANTFQLAPKAAATYSLLFVPTQTGESTGRLSLVSEAAGEFWYELHMTVTETEPEPLPFPPTPIGQSQVMQVNLPNRSDVTSVLTVESTDAACFGVRPPRVVLPAHSESVVDLLFTPRCVGVEQTALVTLRNPELGCWRYKCVGTGTAPLAAEPLTCTCDVGTTATILLPFTNVLKCNTGVEVQLSGDTAAFALRTVPNGVVAAGASASLVVAFTPSLVKRHDAVVEVRPAVRRSDKTCDVTWTYPIEGYCVYRQTQPALRLRCASRMQCDDTVYVHAPGLTPGLAADFSVVFEADPQQSYAVAAAASVSCSVTMPSPYPDGFELNLKFTPLRPLVGSGWVVLRGAECGVWQYRVQLESTPAPVDDTIVLYGDYKESTSVSFDLYNVFPYRSSFFAYFTADSSNDFAVSPAHGVLLPFVCGQRGAATATNLQISAHPSSRIPQIEGTLVVDTDDMQWTFRVLGKFGHQFLPPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SCE5</accession>
    <name>A0A088SCE5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">p-glycoprotein-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ABCB2</name>
        <name evidence="12" type="ORF">LPMP_262640</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700083.1">
        <property type="nucleotide sequence ID" value="XM_010701781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SCE5"/>
    <dbReference type="GeneID" id="22576167"/>
    <dbReference type="KEGG" id="lpan:LPMP_262640"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260031300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_262640"/>
    <dbReference type="eggNOG" id="KOG0055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000836">
        <property type="entry name" value="ABC transporter B family member 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000244">
        <property type="entry name" value="ATP-binding cassette protein subfamily B, member 2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002064">
        <property type="entry name" value="Multidrug resistance protein 1, 2, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="266"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="701"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="749"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="856"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="927"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="963"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="47"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="363"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="705"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1027"/>
            <end position="1265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN99376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1268" mass="139986" checksum="8EB297B38AC8B5DE" modified="2014-11-26" version="1">MMSADQKTKVKATLQDAEEPVSEQIGGQVPIFKLFRYRSPGEWFAVIVGSTAAFCSGGVTPLFMYFFGRMTNNAYDDEMAPQLTRNYAMLMACVGILSMVLVFIKTATYQVTATRLVGRIKCAYFSAVVNQDISWHDGRKPGELISRLTGDTRVVLNGINDRFASWIENLGTGLIGITLAFIASWELTLLIMGSFPLIGAMVYFLSAASARHVSVTRKQYARASAIAQEVMQNIKTVQSFNREMHEVERFSEMVVGSRKAGIKKDFLVAMAGASVMGVILCVIGLAFLLAVYLVQSGRADVGSVAATFLTVMNGAMGLGQVFPALLSFVEARAAAYPIFTTIDEQPAIDLNGPGKEATFQRCIEMRNITFAYPTRLDQVIFRGLSVEIRKGQKVAFSGSTGCGKSTLISLIQRFYDPTEGAVYVDGHDLRDLDLRSWRNRIGIVSQEPNLFSGSVLDNVRMGRRSATFEEVVAACKQAHIHDMILTLPDGYDTNVGALGSQLSGGQKQRLAIARAVVRGADILLLDEATSALDRKSEVEVQRAIDDLTQNSKMTVVTIAHRMATIAKMDCIYFLDGSRYGGSSIVECGTYEELIRMNGRFASMVMMQDTAMGNLRTVVHDTSFYLYPGALDENAGDSVSSVDSYCSDNSWDSNSNGFYEEDDRWSQYSNVDNVPFEHRTDWEERKTSVSMWRIMKMTKSRWWAIVLGLLGSIITAIVFPCVGLTISQLINSLGNYRQTQDKKHMQKQAVLYAILLILLGAVYFLGAVLTGFYGYVGEYLTCELRSLLFQRILRQDQTFFDMPHRDPGGLTTLLSGDCEAVHQLYGPTLGSRLRSVCALAGGIIIGIFMQWKVALVCLATMPLFVGSIVAQQIFFADSEKVRESGIDTVVNEALGSIRTVASFNMQNRVIKRYKRIINIAEQTAERRIVLISILTGVTEITLMGSMALSFWYGGTLIEKNETHFSNVLVAAMAITMGSTLAGAEAGSFATKLRDARDSSNRVFTVIDRVPAVDSYEYGKVNFEEQVGIAFHNISFAYPAREGAKVLNNVSLNFQAGSSNGLMGQTGCGKSTIVQILARFYPISSGTVLINGQDLSFLDLVTWRDQLSIVLQEPSLFSGTIRDNIKYSLPDATEEEVIEAAKTACIHDDIMEMDNGYDTEVGYRGQQLSGGQKQRVAIARGVIRCPKLLLLDEATSALDSITEMRVQRNLDLFQRRFDVTTITIAHRLTTIRHSDQIVLLDSGKIIERGTHEQLLALGGEYKSRWELSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SD74</accession>
    <name>A0A088SD74_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pantothenate kinase subunit, putative</fullName>
            <ecNumber evidence="7">2.7.1.33</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_280140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.33" evidence="7"/>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700358.1">
        <property type="nucleotide sequence ID" value="XM_010702056.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22576459"/>
    <dbReference type="KEGG" id="lpan:LPMP_280140"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280006600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_280140"/>
    <dbReference type="eggNOG" id="KOG1256">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2201">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275583at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd24086">
        <property type="entry name" value="ASKHA_NBD_PanK-II_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.510:FF:000012">
        <property type="entry name" value="Pantothenate kinase subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000157">
        <property type="entry name" value="Pantothenate kinase subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004567">
        <property type="entry name" value="Type_II_PanK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280:SF20">
        <property type="entry name" value="4'-PHOSPHOPANTETHEINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280">
        <property type="entry name" value="PANTOTHENATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03630">
        <property type="entry name" value="Fumble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="363"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="6">
        <location>
            <begin position="27"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="455"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN99651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1459" mass="162113" checksum="0184ECE79B53BC0C" modified="2014-11-26" version="1">MPTNDGGCASARVLSYNFNILPRGSGGYQHERIETFLASIDAYDVVLLQEVYATSYFPYVLQKQLCYQKMLLDGLKAKGLHYYVISRQPSYLTMLRYNVCSDNGLIIASRFPIWHRGSYTFRNHERGEATVSKGCLFAEVEVPAAHGEGSQRIVFFNVHLRPQDNLPSESSQMQQVHRFVEAALTQVREQHNGNNAPGVRQRKGAEVPFIIAGDFNIYGIDPVTGHSSKRFQEMLNQFQDIGSVRDVIYEETGQNPPTRPPILFFPELSKLERYESTPQRQDYFLAEARIQVEKPHLEKYVVSRRRPYTYLSDHFGITCRVTLPLNESDNFQARSYSRLNVSSLVEAANHEHSNPTSDARLEAVLIAVLAWWLFSFSFTSLMLCAALVWLVRWAQHYSASPVLGEPPLLTMEALKEKGDMCFANTAFNPLAGVRTLGEMWERSVARFRTFKCLGATSELGEPEWITYGTVDIRARELGAGLLKMDFRAGDLIGVACEPSRSIVILEVACALYGFTTVPLAGKRSTMRTLLDRHKIRVAVGDRNSVVALLTCRSTKLEAVLYTSAFVDESDHAAAKDLNIRLIPFEFVEQKGRLSPVAPLKEHVTTDSVFTYTMDNTDSVACGDESALLPVRHSTILYDLSLLLMTGVLPSSFKGESMVWFSPMALLFHRVCVLGMLSQGNAIATVDAAHLQEAFVKFHPTLLVTSPALFSTSRLQLSRAQHRHSSVYNWFFNRTFQLRSRLIHLKRQDSSLLRFIFFRAFQEQLGGCVRKIILSVSQESTTFSLLEHISVCYVPLVCEVSYLNCVGVCTIDGTPVPSMQADLEPISDLSNSAGIGQLVVTKKGEPRRRLEIAAQWKRDGTAVFLGAPLGILWPVAYQYAIAAELERIFSVSRYVNAIFVYCDSLKPIIAVVYPNRDTIEFEWHLSHGGDGPARQLGWKELVEYAMSIISADLASIAGEAHLHPSQIPEFVHLYPHAFSDHSTFLTPFGKIRRDAVHSYFSSVFERLYNGSETLPLAALSVDWQEDVSDAESSLTRVSSMCSFDLQVPVTIDIGGTFAKIAFVMPPMTGPLPTFPSIIHEASSLSEKLGVRTFHFFADEEAANNELRTRPHSRVGTLRFLKIPSQQIPRFADYLASIHAIKYFKPQYTTQVRATGGGAFKYASTARSVLGIDFSVVREMDAVVKGLNLVLRIAPESVFTVDSITGVHQPHQLVSSGDGFSPFPYLLINIGSGISFIKCTGADGSHVRVGGSPIGGATFWGLIRTMTNLTSWEEVIEIMRLDGPGDNKNIDLLVGDIYGYNANDLPAMLFSETVASTFGKLGTERFYDLSRGDSTTHFADDDATGEILSPKASKAPSMVSKRPARNGTKAASAIDIVRSLLNMIASNVTQLAYLHARLHGVPNIFFAGGFVRDNAMIWSLISSTMKYWSSGECHAHFLEHDGYLGALGCAILNSHRDATNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SFS7</accession>
    <name>A0A088SFS7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Calpain-like cysteine peptidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_310420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701432.1">
        <property type="nucleotide sequence ID" value="XM_010703130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SFS7"/>
    <dbReference type="GeneID" id="22577468"/>
    <dbReference type="KEGG" id="lpan:LPMP_310420"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310009100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_310420"/>
    <dbReference type="eggNOG" id="KOG0045">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="424753at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015232">
        <property type="entry name" value="DUF1935"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036310">
        <property type="entry name" value="Smp-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF423">
        <property type="entry name" value="LEUCINE-RICH REPEAT PROTEIN (LRRP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09149">
        <property type="entry name" value="DUF1935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101601">
        <property type="entry name" value="Smp-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="4">
        <location>
            <begin position="217"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO00632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="726" mass="80144" checksum="70F8DEEC666D181A" modified="2014-11-26" version="1">MGCCNSKDTKEPKESKEVKPDPVPEPEPVKQVTVVETPDAPLSPKHRSTTVVVDPRIERTRAVCAHNSTCPFRYDVCTVVGGDVKCYFADGIVYRIEKDGVWYLYNDSVDYEAHVEVRFGPGSTITAGDMALETEKTGWICGHCVLYPLQTLCCASGTPNGYKVNITVKPLSEEYRKEACAAANHTAESETDAVRSLVEDVTDEEAVLCRCVESKTPYVDLTFPPNADSVARAGKDSRTLPLMAMMRPTQYLQENKRMSANDFVGPAIPMCLDQGSLGDSWLMCAAAIAAEDEAVVRNMFALGSPEEKVVGAYRVMLNKDGWWHNVIVDDYVPTMSHMPVFGRSWDDPAELWPLLLQKAYAKVHGSYASVTGGDTLQALVDFTGSAMYRFDMEWEEAVTDASKAHSLAEALVQFSSAGASIVLSTPGIHSKSYLGCKQESDPAAFSAHYAEVGLRTGYTYYVERVVIVEKLHVLFKVRNPWRSSGKWAGAWSYGSQEWTQNPAACSLCGVQEDPQDCTFWISWDDAAQYFDGGGVLFSSTGATDYRVKGVFQETIPSAILEITAHESTQVLLTLSQPDKRGVDFKECSSLFAPIMLTMSKKEGSLQRVQKNTSCNPANPSENFNFIVGREVAMWVTLEAGERYHIVPRMHHRGILVPYNRPYVMGLISMNDLKGHVQVEAKQLESDSSAFTNYIAYNSEELPSVEVECQMHLPGKAPVTYVSATVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SGB5</accession>
    <name>A0A088SGB5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_312780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701662.1">
        <property type="nucleotide sequence ID" value="XM_010703360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SGB5"/>
    <dbReference type="GeneID" id="22577704"/>
    <dbReference type="KEGG" id="lpan:LPMP_312780"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310035600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_312780"/>
    <dbReference type="eggNOG" id="ENOG502SE4X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264790at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="245" mass="27124" checksum="6F7EA3CDE5EA24A6" modified="2014-11-26" version="1">MPPASNTPAREKEQLHRKFSAAANALADLYRESSNSYEAGYRDALLFVQRYLQSISPITERRLPPSSAFSMCETVNAQHMAQFLQNTIAARRERMAAVRGIHSLRRRGRENEQENSRFGDACMVSDDGDATENDIHGEEPYLTSQPSSGVTTEPLTDLPLLAASGVVSSAASDFSRATLVVVNRATPALNREREHVVYSDGIVPARLPYQPRRQRLRMERGQSHNSLGAANGHPLSAPLRIGRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SHG7</accession>
    <name>A0A088SHG7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-hydroxyisobutyryl-CoA hydrolase</fullName>
            <ecNumber evidence="2">3.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_323800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20888"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57340"/>
            <dbReference type="EC" id="3.1.2.4"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.2.4" evidence="2"/>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702062.1">
        <property type="nucleotide sequence ID" value="XM_010703760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SHG7"/>
    <dbReference type="GeneID" id="22578121"/>
    <dbReference type="KEGG" id="lpan:LPMP_323800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320045000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_323800"/>
    <dbReference type="eggNOG" id="KOG1684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1737613at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176:SF3">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="4">
        <location>
            <begin position="22"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO01262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="362" mass="38696" checksum="C1FCB4632688A737" modified="2014-11-26" version="1">MRSAVTCIKSPGAALCTDTATCRTITLSWPESLNAMSLPMVQDLHRLYITEPHPNEDAVYVVRGDGRRSFCAGGDLKALTGPDQGTHNPLFYRLEYEVDSHIATMRRTQVAMWAGHVLGSGVGVSVHSRYRVACETTRFAMPETQIGGANDVATSWVFSSLPVRGLGAYLAITGNALHGADVFHAGLATHYIPVEKFDAVEAALAALPSSEGVAACLRGFSADVAVPPFTLAESAPVLAKMFGAITASTRVRDIMDALRADGGAFAASALAVMERNSPLGMTLALENMKRQHAAGCTSVMDSFRGDYAAIQSSIFVAELAKGVEALFVTKEKRPQWKVGSVDEINVELVRKQFELTEGSLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SI66</accession>
    <name>A0A088SI66_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_332260</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702317.1">
        <property type="nucleotide sequence ID" value="XM_010704015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SI66"/>
    <dbReference type="GeneID" id="22578379"/>
    <dbReference type="KEGG" id="lpan:LPMP_332260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330030100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_332260"/>
    <dbReference type="eggNOG" id="ENOG502QW7U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262475at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001185">
        <property type="entry name" value="WD_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002657">
        <property type="entry name" value="WD_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001566">
        <property type="entry name" value="WD_domain_-_G-beta_repeat_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053299">
        <property type="entry name" value="ASTRA_WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44156">
        <property type="entry name" value="SUPERNUMERARY LIMBS, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="851"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="215"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO01517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="867" mass="92115" checksum="08B32D1C7C3E9686" modified="2014-11-26" version="1">MAHKGHTYDVVTTVEALNASFSFDPDCHIDRVLPDASQELVKQVLWATSRVSAVDGKPVADSPELKEALLAAVMRHHSPPPATGAEKKVPTLAVIFPKTRITVTFERTDEHASKVLIEGSVLSDGTVSKVEVLSSAAVQELINEIAPPSTVEPPPALPTMDVDLRGSFRRSMNGHPGVTAALLKEPISAASLNSNSAGGRGFTLATATGGAFQPVTRLLSSSPPPPALQSHNKSSGSLLDLDDSEAASEASSSDFDTVRIWQLKGTSPSDLCVTTPACATAAEPATPGLLEFEKMKLSMRGDEMLRHLGSGVSTFGHAGSDVAEMTVKGRIRRALDRVEMGYCVICVTQDINPIAEIELLALTARKRVVAFDLSIKLRLRPKPEVLAAQFAEAMRSGAWFVMVNAHKSISTCLVLEELLGDAHEHNLEGFDPSARIIIALESHPHFPKALVHHAVVLKLVSNFQGSSFLSDSMAASISRARLVTADALTLSQMGGPSARSSQSSVTSRATVQKPAKKHVRISAAVDIVDIAPREVVQVQKRDCPIDVSGSVALFKTFSGVSGDKFLCVRSAGEMGRFAVGSSCGNVYFLDSLGNSLLQAHAHNASIWDVSFIDKFHFATGCEDGTSAAWRLGGSLSGALVDDAVLVPTAATSLGSDVYCVCYLKNMNPSSLLIGGLHNSLVIREAESEAVHLVPIPSNAQVVDCLPNSATALVGGGDGSVCVVDVMMAKPVSTLIDHTRKLPALAVRDDNQFFTGSFDSTILSWDLRVPGGVTSFLQDGAAAAELSAHTMHTLKLKNYVTGLDVDDVHLAASVGENLYLWDIRKLHTVLGGYPQGWKGLSRGVKVQSLAHLVVTASPDGFVRFWNFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SJN8</accession>
    <name>A0A088SJN8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Non-canonical E2 ubiquitin-conjugating enzyme C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_344050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702827.1">
        <property type="nucleotide sequence ID" value="XM_010704525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SJN8"/>
    <dbReference type="GeneID" id="22578910"/>
    <dbReference type="KEGG" id="lpan:LPMP_344050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340047800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_344050"/>
    <dbReference type="eggNOG" id="ENOG502QRJJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="406045at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018553">
        <property type="entry name" value="E2_Ub-conjug_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057668">
        <property type="entry name" value="E2_Ub-conjug_enz_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31560:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31560">
        <property type="entry name" value="UPF0652 PROTEIN C16A11.03C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09418">
        <property type="entry name" value="DUF2009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-canonical E2 ubiquitin-conjugating enzyme C-terminal" evidence="1">
        <location>
            <begin position="33"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="492" mass="56631" checksum="3A460E550AC6F805" modified="2014-11-26" version="1">MGLLAMGRCRRGAEETYEFREEYAVLDAPIANADHIPLRLSPQERKIQRLMRGVILASSYTDKVDSASALKLKNRELLIVKELTNALTGLIVGLDMRKAAPFVRDREFTLYQHEIRAAIEMCRRYKMMNPDLLRTDYVKFLYMIQDAVQSDMTREALGFNVVKELVTVGRYCEMHSIQDILQDPRLPHCITPVPLMKDRNLLNRCLRCKDIVVGRLVKQYSSEHRLPEDEVEVVVRSLNDANCFSNDNVETSERLLELLKQYFTPSSCTPLTSLAIDEGADGSRLTHSHRMQYTFVLQSLSLWKNMCRKMYILWSIAEEDMLSPNEKYELRMTGQGLQRVQKAPKLYKAVQQVLQETKEELGEWVGSERIHLGDDQVPNAFHFIDKYGQVSRIIIPILRTLGHIDHLEQHAEHAAYLREVWGGGEQAKRAILRDFFRHGFDGSGGDNMDDAGSCIDGRLTSAWNWCNNIRFKEFYPLFLFSGFSSFDGDMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A503</accession>
    <name>A0AC62A503_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucose transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3520300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="XUY36863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="560" mass="60469" checksum="49C056364DF7F8D7" modified="2026-01-28" version="1">MSSKLQANDHPSDSISEKEPARDDLKKSIDDQSDAPPFLSASNAKVILVQAIGASLNGYSIGFVGVYATLFGYSTNCASFNSEQGCVTVPNADCKWFTNTNSTPFCGWTDITCRRTYTYTNLSGMPAAITQCEADPRCRWSYSSQECQNPVGFSSAESGIFAGSMIAGCLIGSMFAGPLASTIGARLSFLLVGLVGVVSSVLYHVSCAENEFWVLIVGRFVIGLFLGVIGVACPVYTDQNAHPKWKRTIGVMFQVFTTLGIFVAAAMGLALGQSISFDQNKDQMVMARMQGLCAFSTLFSLLTILLGIVMSESRAQFGGGEEGAIELDPNEYGYLEMIPRLLMGCVMAGTLQLTGINAVMNYAPTIMGSLGLAPLVGNFVVMLWNFVTTLASIPLSYVFTMRQLFLFGSIFTSCMCLFMCGIPVYPGVSKKLEVKNGVAITGILLFILGFEVCVGPCYYVLTQDMFPASFRPRGASVTQVVQFIFNLVINVCYPIATEGISGGPSGNQDKGQAVAFIFFGCLGIICFVIQVFFLHPWDDERDGKKKGSQLQEKEEIVDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A538</accession>
    <name>A0AC62A538_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">60S ribosomal protein L10/acidic, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2720020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="XUY36915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="323" mass="34448" checksum="72B5602498C20434" modified="2026-01-28" version="1">MPSITIAKREYEEHLVDCLTKYSCVLFVGMDNVRSQQVHDVRRALRGKAEFVMGKKTLQAKIVEKHAQAKNASPGAKHFSEQCEEHNLLSGNTGLIFTNDNVQEIKAVLDSHRVKAPARVGAIAPCDVVVPAGSTGMEPTQTSFFQALNIATKIAKGMVEIVTEKKVLSTGDKVDNSTATLLQKLNISPFYYQVDVLSVWDRGVLFTREDLGMTEDIVEKMLMEGLSNVAAISLGAGIPTSATIGPMLVDAFKSLLAVSVATSYVFEEHHGKELREAALSGSLVGAGSAAAESAAAAPAASSAAAKVESEESEEDDFGMGALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A541</accession>
    <name>A0AC62A541_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3420410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="XUY36805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="298" mass="32271" checksum="66516F3123C82883" modified="2026-01-28" version="1">MGEKQSKGYWQEDEDAPTCNGCGCVFSTTLRRHHCRNCGYVLCGGCSRHRAAIPMRGITEPERVCDACYLALRNSSVIGSSLSRGNPEPIVNPSETPNRPAAWTAGGTTCGPSADLRASDAASLAAAAQSSSAAPELSEEQREAEAFYHNPYGGAAGGQGNSDTTGAADARQETINPEALEKKRLIQRWNTVRQATVYVDILVQQSERVEPDTAVEYSRETEALILEPELPINQLGTRMLPLPRPTTDSARYLVELVTTIGVTGTMLERAAADLTRRLVTRIPARADSRESPDRFVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5E7</accession>
    <name>A0AC62A5E7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Calpain-like cysteine peptidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_270480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="XUY36913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="7420" mass="832032" checksum="47F06BA67E42490E" modified="2026-01-28" version="1">[encoded data, 7420 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5J1</accession>
    <name>A0AC62A5J1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histone H3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1620440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="XUY37055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="66" mass="7238" checksum="D87F239EB5F19D1A" modified="2026-01-28" version="1">MPCARCRACRRRGGPALPEQRDPGDPGGVRCVADGCHEPGQHPREACVTVRPKDVQLAVRLRGERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5R4</accession>
    <name>A0AC62A5R4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATG8/AUT7/APG8/PAZ2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ATG8B.2</name>
        <name evidence="1" type="ORF">LPMP_1920180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="XUY37139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="118" mass="12274" checksum="A4EBC961EE5BB0EB" modified="2026-01-28" version="1">MSAYQSSNTAEARRAECARLQAKYPGHVAMVVEAAKSSKAHLLALPRDATVAELEAAVRQALGISAAKVTLAVEGCTPAATAAVGDVADACKHADGFLYVSVRGEQAMGIFSLCFPFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6A4</accession>
    <name>A0AC62A6A4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amastin-like surface protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2020640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="192" mass="21519" checksum="A1C1C1B14E8B38A4" modified="2026-01-28" version="1">MEWNIALLLYAVVQFIAFFCVLVATPLDMFRFRVNFFNITGCLTLWGFKDKCSDISHNFTVYRVWDECPGRLRLFRAVEAFAIVSILVYGTAFVLGVVMLFCRLILRWICLGLNIAGAITVCFVWASMVVAFLRDGDGPCPALQIFAQYGVGFALFVVAWVLDIINIFLLVLSIGTTISTESGQVEQKEGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6G7</accession>
    <name>A0AC62A6G7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ubiquitin-conjugating enzyme, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2020760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="166" mass="18648" checksum="C69FB556B5389A7C" modified="2026-01-28" version="1">MSARTVRRAHMDFARLKELASRGSSTIRAVDMADEQGGTASGDAFHWRIRVMPPAESVYHGTTYDILFTLPQQDYPFKPPVVRVLTHIFNPMIAENGAVCEGLLQNDDWKPTTPVMDVVARVVKAIFLEYRTYAVLNEKAAGIMSTTTPEEFQKHVQRMRASDSCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6H0</accession>
    <name>A0AC62A6H0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histone H3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1020460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="XUY37380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="130" mass="14775" checksum="3B7AC1682C1CB152" modified="2026-01-28" version="1">MSRTKETARTKRSITAKKSKKAPSAVSGLKKVHRRWRPGTCAIREIRRYQKSTELLMQCAPFQRLVREVSSAQKEGLRFQSSAILAIQEATESYIVSLLADTNLACIHAKRVTIQPKDVQLAMRLRGDRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6N2</accession>
    <name>A0AC62A6N2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_030260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009372">
        <property type="protein sequence ID" value="XUY37417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2259" mass="250527" checksum="B06A3F653D48E113" modified="2026-01-28" version="1">MVPQDRWQPQNRVKVCQYQDCGASFGFFSSKFNCHRCGIVLCSTCATTKTVIPRYYNDQAVIVCQRCFQVVERYKERGPSAAGYLIHSGAVSSTPARNSPVPATQSTPAPVSPGAAQHYATEVPSTPTIPQKKPVLDHSRTLITDSDLHALQDIIQTLQKALAEEQKTSAALAAANRTDLHNLTEENTALKNALNLLQQQQQHNEQANTQHHDSSQLLQQRSELEAQVARLAADRDEARQQLGATADELQQRLDAATRQRSELEAQVARLAADRDEARQQLGATADELQQRLDAATRQRSELEAQVARLAADRDEACQQLSATADELQQRLDAATRQRSELEAQMARLAADRDEACQQLGATADELQQRLDAATRQRSELEAQVARLAADRDEARQQLGATADELQQRLDAATRQRSELEAQVARLAADRDEARQQLGATADELQQRLDAATRQRSELEAQVARLAADRDEARQQLGATADELQQRLDAATRQRSELEAQVARLAADRDEACQQLSATADELQQRLDAATRQRSELEAQMARLAADRDEACQQLGATADELQQRLDAATRQRSELEAQVARLAADRDEARQQLGATADELQQRLDAATRQRSELEAQVARLAADRDEARQQLGATADELQQRLDAATRQRSELEAQVARLAADRDEARQQLGATADELQQRLDAATRQRSELEAQMARLAADRDEACQQLGATADELQQRLDAATRQRSELEAQMARLAADRDEACQQLSATADELQQRLDAATRQRSELEAQVARLAADRDEARQQLGATADELQQRLDAATRQRSELEAQVARLAADRDEARQQLSATADELQQRLDAATRQRSELEAQMARLAADRDEACQQLGATADELQQRLDAATRQRSELEAQVARLAADRDEARQQLGATADELQQRLDAATRQRSELEAQVARLAADRDEARQQLGATADELQQRLDAATRQRSELEAQMARLAADRDEARQQLGATADELQQRLDAATRQRSELEAQVARLAADRDEARQQLGATADELQQRLDAATRQRSELEAQVARLAADRDEARQQLGATADELQQRLDAATRQRSELEAQMARLAADRDEACQQLSATADELQQRLDAATRQRSELEAQMARLAADRDEACQQLGATADELQQRLDAATRQRSELEAQVARLAADRDEARQQLGATADELQQRLDAATRQRSELEAQMARLAADRDEACQQLGATADELQQRLDAATRQRSELEAQVARLAADRDEARQQLGATADELQQRLDAATRQRSELEAQVARLAADRDEACQQLGATADELQQRLDAATRQRSELEAQVARLAADRDEARQQLGATADELQQRLDAATRQRSELEAQVARLAADRDEACQQLSATADELQQRLDAATRQRSELEAQMARLAADRDEARQQLGATADELQQRLDAATRQRSELEAQVARLAADRDEARQQLSATADELQQRLDAATRQRSELEAQVARLAADRDEARQQLGATADELQQRLDAATRQRSELEAQVARLAADRDEARQQLGATADELQQRLDAATRQRSELEAQVARLAADRDEARQQLSATADELQQRLDAATRQRSELEAQMARLAADRDEARQQLGATADELQQRLDAATRQRSELEAQMARLAADRDEARQQLGATADELQQRLDAATRQRSELEAQVARLAADRDELQQRLHGMVRRCISLEWEAEQRTDEIDDSQQPLCEVCESLKLRQAAAEAENADLKAHLRQLVEEERRLREALSCVRGGQLLDDAGEVQPVGLASLVERILDEADDLRSRLAGSTEEVKLYRSHALQERESARNQITKLEAEVAYLMSERDIAHQQGFRDLSEVQRQLDDAVQERDSARHRCAGLEAKMAIMESKLKAAKAELLEVSEKASSLWTRLSASYGGVPVRPGSSSPSSSGASDASTVLGVVGNSLVPQAAPYRDAALIAEVGRRLHERGEMMRLFAEGVELRECARPLEEVLTESLIEEHHTRDADAVATGYTRLSRNAAHSHRLDTREAQLNKRATQLKEKERQLLCVAHELQAKSRALQALYMRVAEKPPSASRLLLTADGGDAFHTTSQRHGTGTTFREAMRQLDGGVPPDDGTAETAMYSDPVSPLPRVPPQPLMQAVRRGAEMLDRSDEEVAVTDIVEETPERLTAATEAYRDVLYEHILESNGLQGMDALTRYLPRRAPGSGLRTPRVPSSDMAAKTRAMLRELEDRLGNSRAVPRGVDPAVQQRSLEAFRRLEAAMCALCGDRGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6W8</accession>
    <name>A0AC62A6W8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Surface antigen-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0920310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="XUY37351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="125" mass="12520" checksum="865C57B86962E871" modified="2026-01-28" version="1">MTSTRNKFLLALVALVLLATYAAAVKGDCSVENCATCLEEDATQCAECNNGYRPTDAGQCEAISCDVPNCATCAAGSTTQCAECNADYQLTTEGQCVAASDAAAAPHSGVAAVAALAAAVVAYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RGV6</accession>
    <name>A0A088RGV6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_010670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009370">
        <property type="protein sequence ID" value="AIN95167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696709.1">
        <property type="nucleotide sequence ID" value="XM_010698407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RGV6"/>
    <dbReference type="GeneID" id="22571796"/>
    <dbReference type="KEGG" id="lpan:LPMP_010670"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_010010600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_010670"/>
    <dbReference type="eggNOG" id="ENOG502SIR9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267459at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="292" mass="29814" checksum="43A806E0D6B06F88" modified="2014-11-26" version="1">MPGVDLLDAFAELVVRVVFSLPHTEPDRTSSSDEDVPCGANSSGTQIFSHTNLLEEEQQLLSDTSLAHITMNSTCVGSPAMLTTSCSNPVSRGSSAASLDLYPGGIWNPLARVPAAAAGNGARSSHPSSVVSLGTGDNLSTPRSGPSLWNRILGGSGRTQTPPRTPSFSPGPHTGLTTTMSSFVQLTDEELGVGAAVSGRGGYSGAGAAHSLGAGSGIWGGLSTTPITVFSGDSTPLRELCPLPSPPSSNPHQQPQFACSHTLCLGQSLTQSSSGNGGHRSQRSSSSEFDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RGZ3</accession>
    <name>A0A088RGZ3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_020530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009371">
        <property type="protein sequence ID" value="AIN95232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698197.1">
        <property type="nucleotide sequence ID" value="XM_010699895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RGZ3"/>
    <dbReference type="GeneID" id="22571863"/>
    <dbReference type="KEGG" id="lpan:LPMP_020530"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_020010500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_020530"/>
    <dbReference type="eggNOG" id="ENOG502S4V8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="278391at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="304" mass="32395" checksum="506B0534D8A94F8C" modified="2014-11-26" version="1">METPSLSGKDSNAEPSATTTDSPLPPASTAASVEDLKRLTALGTLLVNMGAASEEKVFGMKDSAPMLAYRANRMRELLVINRPQDDAAAHPFIWHKPWTWWSSGAQVSPIAVRRESTQEEGASAPGTTSRPQRTGSTQTEADVVAPPPPDTVAPKAAPPKRKKGLPAVDIRALTDEEAEALTPAVRDERAKLLRSEMRIHELLQGLESTRYRYLAPSHDFKCEAEVMAVIRCYAERNQARAASLAAEGGGAPPGTAAASHNGVSGGGEKAVVRADLLACGPHVKHLKVCAESMVMKYSQEGEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RH64</accession>
    <name>A0A088RH64_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_020130</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009371">
        <property type="protein sequence ID" value="AIN95193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698158.1">
        <property type="nucleotide sequence ID" value="XM_010699856.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22571823"/>
    <dbReference type="KEGG" id="lpan:LPMP_020130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_020006300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_020130"/>
    <dbReference type="eggNOG" id="ENOG502S80B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="46189at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033370">
        <property type="entry name" value="COG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="118"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="606"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="795"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1115"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1305"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="288"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="606"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1305"/>
            <end position="1318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN95193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1956" mass="204047" checksum="CF03F657984B8D18" modified="2014-11-26" version="1">MTMEEAAQEVRRILCQNDVGEALHYLSTVARSIEANQHDLRAVIGNSYRDLLGACDGVVGMERDCADILTIEEAMERLSAARDVDGCSRAGAADSQPLLPPSWFATRLRRQRRVVTAAPTSIATAGNNNNNTSSDTPSHRLVMKGYATTSRSSRRRSEGNRGANASSATNGDCGRNVPNRRELDSALGLPIVELPLPPVGPTYVKSKGAHQSAAVDGETGSVAFIGQRMYVSDELQTLHLDYMALESATASMGRGTAAVDAELSSLLANSTTLAASVLLPAHQLDERQDYHDSSHAHHSPHDAAALAAESRKKHEDLLCALERDLPLLRLARRLRRVQAFLLLYTDDNGSVQSSMCIGDAPTASSVALADVRGQSMMRSAKQPPSWVTGFQRRVTALETRLVKLMLLRLRRAADDYAWLVEQRNRLAEQMLKVATESDPRDSFSETRTVRAAEKRHLMYVWVTFAQFHGALRALRGSPTLVNALVACAPGAALPGKSGVRPSGTQDTRPAASSTGIASLEGAVDALYQLASQDVQSIVSAVVGTAAAPVASAAVGEVLPGVADPSRMLLAFLAVLLLRESQLNAVRWTAVAPSFMSDALPSASAQPQTATYSSSQPSSFLPANRGGGGGGEGTAAAVGRRWSCPKSEGDVTLLPPTATSTKTRVFATATHLSALGLVAATADHPTTSTTTPVAVGNETPNTAWALRCFSGLSFLLRAFADYVDLVQAASAEVPPAAAGLHEETVVLSLLQRACVADEEASGEPREVAGHVAGAVAGAQSLDELLQWRLRNASGSAAASGVPEDSPGTPLGSFAATDTLPSSLVGRSDTPMRDSDGIVAVNVALGVAPSPAGAVTRRRAYVELLRASVNTVDELQVSIAPSMAVGERLLSSLADAAATEDTSTTSEAADLVSLLRLVCHQLLAPCVSSLVVLLARDPVVLAGHSEGQRRLDTTPAMHEAREALRQPLQGGLPHRLLSGARGPRIPSGLSGLGQTWAAVDTARWWELVEQTTVHAALQRCVTVALESVSFVEVCISQGLITSALCMLQGSVEGSDTEHEHHVSGVSGDGNTYHGFTGASALENTWPALFSVLRLHALSTVDSASDAGVSGSLDGAARASRAETGQRGVPSFTGSTTLAPIRGHTGRRGERGGLSSAMAGIRWARFRPRAATGTAGSAHGTLRVTSGEGIFSEEGLEWGRAACRAARLPLSGMSDTVDAKGVEQQPALDAAAANAGLSASQQAQLAAILSGMRDMLFPDWEARFSAEQESMGGAQLCVPHMNGHAAELLHRCLLTLVEAVQAQTAAVQTSAGDGSAGSPPSTLSPPPPLHMRIERWLKDALHRVAAQLRNTGTGATPNETNAAVVHSYELSLLVRVYLAALQALRRAAPPSEETRLQQLCAEAEDLYERTQAPWQAMIIQLYRTALQQAYTSLLRPRESGGKESASPAVASRAGTTLRRMTHLYSAAWVRAPMVGDAAPGDSSASGSHGIAYPAQPTPAVMMLTQTVLRYLHQALYGVPTVFSDSPELFMPSSRTEATHDASAASRQGQSDAASAAASVRFSGARRCGLHMLVMEKERRRVLERLAETSAEVYEFELCPLVDVIGESGDRAAAALVSVVSVGNTAPAAAAATQSQADHVRLQWYMDVLFTSSVWCVGRGSAGSGSSSSAGLFATEADSPAMPRFTPDAGRSGVRADAAASFVDGPLRRVARHLESTCDPVRWRSGAPLVLSSFHRFISASAHLWVAHSEESHEGGVRDTRSGEALHAPSVAAAVASKPFAATGATAAAPFSAEQLLFPRERVNRLALLPIAVSPNAALAAAAASVGSGGTPSAAAASAAALVPQTYLRVPQTASELSPYQTSSSTGVLPTEPFRFGGASSAAVAVAAAGGGVGVSSLVYPTSGDHDASPGWALGGLGESDVIEVGGATAPAGSTSAAASAASALWGTTQRGWGQLWGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RH75</accession>
    <name>A0A088RH75_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_030920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009372">
        <property type="protein sequence ID" value="AIN95327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701035.1">
        <property type="nucleotide sequence ID" value="XM_010702733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RH75"/>
    <dbReference type="GeneID" id="22571958"/>
    <dbReference type="KEGG" id="lpan:LPMP_030920"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_030013900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_030920"/>
    <dbReference type="eggNOG" id="KOG0231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270720at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215:SF14">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="317" mass="35349" checksum="1901227D15883CB4" modified="2014-11-26" version="1">MQQVNIDEIDVVTGFKKAELYVWNAYAAVFLAEGTEPETDVDTWVDDFCQSSAENDVAFDRNFVKSVCTLGIYAGPRDEFQQRSGCGKATYASGDTYEGEFFDGKKHGRGLYTFVSKGCCEADRIVAKEVEQLTAAGKDPRAMIGEIATKLQLGRHIVDGIMQYGQRPCYQGDYVRGMRTGRGVMKNKDGSLYKGEFLENKRHGQGVFYYLNGDVYSGNWKAGAKDGYGAYHFVDGSEYRGEWVNGNFVQGQWILQGGSYYEGKFDKKNRPLDDAASMHYPSIEMAQRGTFKRGVWAPTSVLEVCSEVPVDGMAWAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHE4</accession>
    <name>A0A088RHE4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial processing peptidase beta subunit, putative</fullName>
            <ecNumber evidence="12">3.4.24.64</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_010650</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.64" evidence="12"/>
    <dbReference type="EMBL" id="CP009370">
        <property type="protein sequence ID" value="AIN95165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696707.1">
        <property type="nucleotide sequence ID" value="XM_010698405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHE4"/>
    <dbReference type="GeneID" id="22571794"/>
    <dbReference type="KEGG" id="lpan:LPMP_010650"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_010010300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_010650"/>
    <dbReference type="eggNOG" id="KOG0960">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251424at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000076">
        <property type="entry name" value="Mitochondrial processing peptide beta subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000008">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF149">
        <property type="entry name" value="GH01077P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="10">
        <location>
            <begin position="44"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="11">
        <location>
            <begin position="201"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN95165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="499" mass="55693" checksum="0ABA97D8EAD75D17" modified="2014-11-26" version="1">MLRRTGAVVAAALPHNMTMKDPLCQQVLGRCTPVVYSSLPNGFRVATEYVKDCPFATVGVWIDAGSRFEDIHNSGVAHFLEHMNFKGTDRYSKSDVENLFEHRGAHFNAYTSRDRTAYYVKAFTKDVDKLIDVVSDLLQRGRYRRHDIEAERPTILAEMREVEELVDEVLMDNVHQAAYDPTTSGLPLTILGPVENIAKNINVSMIEDYVRVHYTGPRMCLVSSGGVSPDAAHALAEKYFSGLPSTNNRPHLHGVYKGGHTVLWNERMATANTAVAFPICGASHPDSYPLQIIHNVLGQFREGQYDQFSSQRRNPNLPWERVPNLVQLRPFYTPYEETALLGYHIVTARMATSDNRSDNGFARDDAQTLILNYILSSLYDLCATKVEESLLEAAKAEFKASVMMMRDSTTNSAEDLGRQMIHFGRRVPLEEVFERVDAVTPESLRAAAEKYFGVVQPTVSCIGASSTLPKYDPLSLASAVVRPQLTPAQFPQAARTCPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RII9</accession>
    <name>A0A088RII9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MIP18 family-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_071070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009376">
        <property type="protein sequence ID" value="AIN95792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704114.1">
        <property type="nucleotide sequence ID" value="XM_010705812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RII9"/>
    <dbReference type="GeneID" id="22572442"/>
    <dbReference type="KEGG" id="lpan:LPMP_071070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_070016000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_071070"/>
    <dbReference type="eggNOG" id="KOG3381">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2746at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140535">
        <property type="term" value="C:intracellular protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990229">
        <property type="term" value="C:iron-sulfur cluster assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000005">
        <property type="entry name" value="Mitotic spindle-associated mmxd complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039796">
        <property type="entry name" value="MIP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIP18 family-like" evidence="4">
        <location>
            <begin position="43"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN95792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="162" mass="18606" checksum="C0C3A4372B9BBE0D" modified="2014-11-26" version="1">MTELVNPNPIVFEPTHDPLKGRTNAERAAEDDEDAEDPIDAWEVFELIRRIRDPEHPNSLEQLKVVEPSLINVNWKKRHIRVLFTPTVPHCSLTTLIGLSIRLQLERSLPEYTKIDIYVTPGTHEQEEQVNKQLNDKERVAAALENRNLLNVVESCINGLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJC1</accession>
    <name>A0A088RJC1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">EF-hand domain-containing family member C2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_080920</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="AIN95900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704222.1">
        <property type="nucleotide sequence ID" value="XM_010705920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJC1"/>
    <dbReference type="GeneID" id="22572554"/>
    <dbReference type="KEGG" id="lpan:LPMP_080920"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_080012200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_080920"/>
    <dbReference type="eggNOG" id="KOG0043">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10255210at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.170:FF:000004">
        <property type="entry name" value="EF-hand domain containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.170">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006602">
        <property type="entry name" value="DM10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040193">
        <property type="entry name" value="EFHC1/EFHC2/EFHB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12086">
        <property type="entry name" value="EF-HAND DOMAIN C-TERMINAL CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12086:SF11">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING FAMILY MEMBER C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06565">
        <property type="entry name" value="DM10_dom"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00676">
        <property type="entry name" value="DM10"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51336">
        <property type="entry name" value="DM10"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DM10" evidence="12">
        <location>
            <begin position="115"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="DM10" evidence="12">
        <location>
            <begin position="279"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="DM10" evidence="12">
        <location>
            <begin position="474"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="11">
        <location>
            <begin position="637"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00035003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIN95900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="859" mass="95977" checksum="9808C2CE3802531C" modified="2014-11-26" version="1">MSSDPRLRLSMANQSNVPKEYVRAVDPQLLPPRVGHNWNDQAFRAKQGKPQQLEAEFRGRRVFPATQNRTFPAQAPDMCRTAQQLVDALMSSSLNRNTATRKARAAEELRHVTLEDKVLRFYAFFNEPAPEAGAASFWHRKVVISFFPVDDTILIEEPHIINSGLDGGVFLKRQKVVADPRQREKFPGEEYVSLNFFNVGDSVRLNATDFFLYDCDNFTRDFLTALGVEVGAPVGCPDDLFMSEYGRYQERLKSGKFGLLSQDYAADEAERSVRFLRDGGMVLRFYALLDERDSVPGGMVRRLEVMLFVEDNSISIVQRQSSSESCRGLYLSRCWLPKCGSVAKTNELTFTHRVNGQREPDMGIPDAYYRDVDLDVGMTLNVFGRSVFLYDCDDYTREFFMQRYGVSLHPPIDVSNYLQGDARRTVLGTEGPTRSVDSVRGVVGQPASAADAGDDDGSLAVASVNSAAAAQDIPTDTLRFRAVLARPANHDDEQRRFTIAYYTKSEEFVVHESAFPKAGIHGGCIWKRKKVMKVPPKPGPRNAPKPLVVPGEVPHYTLSDLGEGKELVINGLPLRLYRMDAHTATFYARCSGTLTEDTTGGPAVVTDATGAMVTVDHLVSELRSYLQSRYGTGVASFLALDRDRDGIVSVPEFTMAMKAFQITEDKGAAAAIFARITPARDTGYFTSVDLMKWMDAASEDHRTTLVRTARMPSGGREAELKEIERRAVRSKVLRELKFRLDARCWKGADMFRLASTMPRAYGGRRGDLYSFTNPDRDTVITPVQLRRCIEEILTGTPTAAEMACILEFFFPSLPVEAYTQTRDNGTAHAVDLNEFQKRYYIMTKETMLPDDGEAAASSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJJ4</accession>
    <name>A0A088RJJ4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_090640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN95980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704302.1">
        <property type="nucleotide sequence ID" value="XM_010706000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJJ4"/>
    <dbReference type="GeneID" id="22572634"/>
    <dbReference type="KEGG" id="lpan:LPMP_090640"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090011600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_090640"/>
    <dbReference type="eggNOG" id="ENOG502QPTM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF159">
        <property type="entry name" value="LD03170P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="533"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="739"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="847"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="753"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="847"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="923"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="935"/>
            <end position="959"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1237" mass="131538" checksum="76BA88A6E8367F12" modified="2014-11-26" version="1">MSNLQMPAADAAVVCLRVLGHLLQDEEVTLAQLSYLIENIHNPLAQVCLPPSQRPIVVAAPQLSSLPPSVLNRLSPPSRYAYSSASSPMAATAASEAKARRLSPQPAVCETAPPAQQQQTTSAKKAKTTAKAHKTVYGASMKSVANAKVSSSSTSEAEARVPLTSRQYWDTFANLPALYTVYLALVRQLDTMLQRLTHIVEELHLATRDTANSGAAYNPSPGTALGEDMVSAVSHSSAATPASALRNPSPSAVAGACSVYREIGAIVCEFFESDQMKHFMAEHMMYAVKYTQRTAPQMLRLSRLWRWCAKSSTSSRVSVASLAHLSEVDQKTILQNELFVDFLWRSFGPSGIPEDGRVCIPASSGLKRPTTAGGQGQAPSTGTPVGGGGGGARRSYPTPAAPPPAAHLPPIPAMWEGFRTLLVLLATPLNILRRYSHVARCLVESDALLWEDRERLRSRFVNIAAWRISEETNLVMEELSLHDVKGIMALMDIQGASTNSGGGVGLAGGESINNSSASALTSAEISLDYSHRILIHYGRLLKRFGRGRHERLIFLFSDWLCYTEESSNGHLRVRGTIPLSGLHVVKVRDDTSLDTINCFELVLSSPPKRIIFYAPSPEQRDQWVDAIRYTVQRFGERQKNNQVVVSGSARDSKMSATARNGGVLRVMRPTAPMLMSNSRLSRQRRNDAVCQGHGDLQRRIAEMAPQPSRMISESAGASSPAVASGLECGSLSISVSHSSPLANAPSGGPSHDGSFSPQLSSSTHRQLDCDAPPCSQLASVDCRIRSQDFIASHQQHLADSSSSHIVPPTQTVGAPPGIGGVTGDTNSSLNCIVVPGLEASNMDRVSSVHTTERSASPHHQGSYQLSSPLISAPVVPPPAGRHSTSSLRSLNIDGMASTNGSGGGGGGSSVSTPLRRTVLGRFEAIKRSGSEKSQQRTNSASLRDSLTSTWERQPQQGSSPFPEKVSHRDGGSTAASPPLSHAVHNNAAMEEEEDEVAQMDLTAKVSESIEDDDQLVSLVSLRHAAAAVQSSLSSELLGLEAHQDKEDSTSSSVILHHLINPVDCPTLLNGGMQASNAPPPDTSCAQHSHSVTQGPINGNVDSIIKASPAAAAVHKTNRTGSVMSAGAPLEHSVNGSVEEDGSATPTAVVTACRPPRPAHRRPMAPTPSFVKKSRQVVVAHEKGNVPAPFRAFIDSPTDLGTGLAKGMGAEEPLNEAVTPCHVDPVVKGPHDRDSVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJL6</accession>
    <name>A0A088RJL6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_040370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="AIN95364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703686.1">
        <property type="nucleotide sequence ID" value="XM_010705384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJL6"/>
    <dbReference type="GeneID" id="22571996"/>
    <dbReference type="KEGG" id="lpan:LPMP_040370"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040009700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_040370"/>
    <dbReference type="eggNOG" id="ENOG502RY93">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="418911at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="184"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="312"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN95364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="360" mass="39094" checksum="61A50A08C10CA2D0" modified="2014-11-26" version="1">MAEPLTRKRTESLSKIYSKKPISEGYALWDRDYLLAAMRVFTFKAEGAPPFVLAPYLDSVAEITLQMHDLEDAAEQFAIAAGKYQLIDQKVLADLMRFKVTEVSSSAEIALEQVQAYLAAQDPQANGGGETSTAQTKSALARVYAYLADLLLGSLDEEKPDEAVLAQALTAAELAVRLGWDRDHCGWLIVGDVHAASGNYKKAKEAYGKALQRCPHYAKALERQTGVLQQLVRAAEECGDDASKAALNKELLSLLDRSIEVHPLANTFREKAFLLSEMEGDDAALAFVAETLEHPPQEEIEVIGSSAKETTSTLLKAKAAILADGNQLDAALEAATKALEVNPNDDEARSIICDLHESMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKW8</accession>
    <name>A0A088RKW8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_130510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697133.1">
        <property type="nucleotide sequence ID" value="XM_010698831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKW8"/>
    <dbReference type="GeneID" id="22573161"/>
    <dbReference type="KEGG" id="lpan:LPMP_130510"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130009200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_130510"/>
    <dbReference type="eggNOG" id="ENOG502S4JQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267483at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="308"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="426" mass="45199" checksum="DBE7C33D370F87AE" modified="2014-11-26" version="1">MTHMGRGADGYQRPGNNCQQFTPSSQSAALRTAVMAAASPAPVLATPIQTRPLQGNPFHPLLWNGSAGRGGVQTSFSQKSRAGFTLGVTVGSSSGPLSSSFSLSTPRSSCASVVGSGDGRLQRRASRDGLEGSTPLSSSTTAHVLRPQRPTQSRMPPLSSSPHALVGLTAAEASSAVSTTKLSRERKVAAVNYNALFHQELQQPKPESDTGAWPTPPLSRPTGAFQYAQLPPSASAVVHDTGGHSGSGEGGAVSPLPSVTALSAQACTMEGPLPPDVRRIIAQSCTGGSSAADRNTIIDAAEQQARRLISTGRRVKVYREELAAAEEERRDLSTSVEERQLVRSVLQSEVNDINARIQALLQERALVEVQLCAQDDAVAREGRKLTEAQERVTILREAIDGIVEETVVARLMLRQQVPSLHIENYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RL01</accession>
    <name>A0A088RL01_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CCDC113/CCDC96 coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_140210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697256.1">
        <property type="nucleotide sequence ID" value="XM_010698954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RL01"/>
    <dbReference type="GeneID" id="22573288"/>
    <dbReference type="KEGG" id="lpan:LPMP_140210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140007100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_140210"/>
    <dbReference type="eggNOG" id="ENOG502QS75">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10254794at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051885">
        <property type="entry name" value="CC_CF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025254">
        <property type="entry name" value="CCDC113/CCDC96_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15654">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 113-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15654:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13870">
        <property type="entry name" value="CCDC113_CCDC96_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCDC113/CCDC96 coiled-coil" evidence="6">
        <location>
            <begin position="281"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="410"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN96603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="443" mass="50942" checksum="CB14BE3A1F44A26E" modified="2014-11-26" version="1">MYEDAEEHRREEACQHAAASVIQRRWREYQELRGVVPDAARRSMFSSGLLLVAPGAFGGTDEKDGSEENDAHPPLSNGGFDEFAQASQTLEKKRHACVEEYRALLAKRKALLEKNLAYQQLLSRHYAEQRRRNGEDDVTQLTTPDAEAAYWVLVRQVAEERQRVAGRSAALKKDLELQRQRYEPIMEEVALQEQNFQQHIRELAASVRFMRSSRPIPTDAIAQYVEREVVQRSAIRASRVRYFQLKNRLLRLHRAAKGGAASPSSNSAATAATTGQDGEESNAANHHMFLIDFEQLKVENTTLNEKIEERSEEVLKLRSKVTNTIHIATHVREKLDCVRMENAGLRQHVASTDEELGGARDQLAKSKRRRDAHLRANTRMKERMPLVGSRDLLMDYEKRKAVIYDYRTRLVQLTDRHKELTERIKQQESTIISLQHELSHYPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RL34</accession>
    <name>A0A088RL34_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_141290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697360.1">
        <property type="nucleotide sequence ID" value="XM_010699058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RL34"/>
    <dbReference type="GeneID" id="22573396"/>
    <dbReference type="KEGG" id="lpan:LPMP_141290"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140018500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_141290"/>
    <dbReference type="eggNOG" id="ENOG502S1UT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="252229at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="363" mass="38857" checksum="74F561AE8AB467AA" modified="2014-11-26" version="1">MYNPALPNHYRDVVFTEYVRRRKREDEAVAEQQREPNALASALSASSLASQSLAAVSAPLLGLSAEELHQHRIKESAALGIQRAVMMEKEALEVEHKTRKLEGSDARSRISSRLDKLKALAAKSKAVTGTSASVGACGTDLQPDYPLSPKPSQGTASPSLATEAVPSSPLVFQPSSLAAGGYVMTAADPSLPGMLLRTAKRPSVHGKPSSTLLLRFLHDSPVQGWSGAAIAEASASPSAESPLCAPVLAQVQQLCRRFGFLRSMAARVYAEDAVTTSLTRARSQTGEETPVPSAEETRREQLRVWVRFDSVTEAFKAAESLTKEVSPGAPAGRPVFSVYFYPTGLYDSGALELREEDLLPPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLL2</accession>
    <name>A0A088RLL2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2 NT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_100100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696732.1">
        <property type="nucleotide sequence ID" value="XM_010698430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLL2"/>
    <dbReference type="GeneID" id="22572746"/>
    <dbReference type="KEGG" id="lpan:LPMP_100100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100006200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_100100"/>
    <dbReference type="eggNOG" id="ENOG502QWQ7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264966at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="464"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="607"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="667"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="282"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="501"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="521"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="609"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="731"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="755" mass="82568" checksum="6323F3A3E162840B" modified="2014-11-26" version="1">MPHETHVLRFKVVTVECPTMPTGQQYTIMYHRGRTSRSTPCYTAQSGVVNFATMPEGAALVHFRSGHGGMRYAPKYIRFMVEEYTRGQPRRLVGEAEVDCTQVLKDYSSSGSGILTVVFRLYGNAAKMQIAILVYPEHALPLSFDGLIDPNEATVLPPPQSVKVMNRGEAMMILMGLETLLERRRTMELEGQKKPQSREEKQLEELIKIRKALVNSEGLATEVIKTRCEEVVAMQYIAHARKYRNNFIGETGAYLREMAISNGDDFISDEGGKKGTTVLEQLNRVNHSIEDVRDQVKRLKEEQIALDRIQPKTDLTEDGRKNLDKVAALEKKLQLLQQSRTALTDALKKQAAKKDTPLSREMAAINARIAALNAEQQQMTPKIQHMMEVATSHVVKWARSKNPPEPEIRNRINVLRDTSDKDRDIFDGLLDDAGTSQNSNEPTTLADMQHKHVLKLLKGLAVTAPPPTAHSAASSSSSSGHRTPQNVFDGAGLPAMGDFSVTKKVEEEESAAKKPNAIAESVREDSPTPAREDPLKPSGLGIDMFSSTPASAIASTVQAGLPSMGDFMHSSASLRQQGLEPVFDFGTVLQAASVSPQMDSNFVLEPQRSEQPTSSFATAPPAVTNSYNKKDDPYYDEMDDFTVPAGTNNAKNYGTVEIVGDFPDFGNDGNSSVRADRDISSSPGYAAPRPTFDFGPSGGGDESSGMRGMALPAEAFSFGAAATDAPSANNRSDRSDHSDDPYRGVTNLPTYNFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLX3</accession>
    <name>A0A088RLX3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trypanosoma Tc-38 (p38) protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_160640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN96938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697591.1">
        <property type="nucleotide sequence ID" value="XM_010699289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLX3"/>
    <dbReference type="GeneID" id="22573642"/>
    <dbReference type="KEGG" id="lpan:LPMP_160640"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160010400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_160640"/>
    <dbReference type="eggNOG" id="ENOG502S8VY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266271at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045399">
        <property type="entry name" value="Tc-38"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20054">
        <property type="entry name" value="Tc-38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trypanosoma Tc-38 (p38) protein" evidence="2">
        <location>
            <begin position="237"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="659" mass="70603" checksum="046D2926B728D451" modified="2014-11-26" version="1">MSGAALHPSRTLRLYAKTLTEMVPRNAALLHGKSGAGNDWAAGNAGCGPRGAVDGDWDAGTQRSDAHDALVEGDEPMYQVSVVHADTVANQATAALRSLLGHPRLSSSAVAADADGEDQLTDAGAPATPERVRDSDEVRRGMAGSHLPAERAEPGCGDAVEGDCESNGEEELLENAEAFADEVEMVGREGTAAITAVKEAPLSEETIAQLQNSGGGQRPARSGVMPYSAGEPVNLYGSRYWGDIANALRSAAESRRFLSPFWSSQTAFERVGATVVVKEEEGVLVPTTVSVAVRLFNLEQTTLATEFRAATFVEVIARLRQLRGHETSSLSRGYGGNMQPLNLAGDSLSYQRTCAISDSPHFIRLQTQSPCWLSEHEVHAIGASVRSDEVEFYTLVPLSAFAPLQERRAAASAGAGLSGDARADAANVSALDGEASTDTSRGATRYYNVAQLDDPERFARLNPMRDPLARCFSSRGFRYASTTTWLMWEYCARYHFPLTGTPRIIFLTAETIFRLGGRVVQTKRYPLSCKQTYRVDDTTASSSSSSTAFADVWKAPLSTSAAAPPFEKHRATCHGELDVAPACGRVNTRTCSGFGVRGDADGANSTAADAGIVPPPFTMVMHGEVVSLCNALQTDIADLIFDRVCGLHEHQSRKWCVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RM15</accession>
    <name>A0A088RM15_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_161040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN96978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697631.1">
        <property type="nucleotide sequence ID" value="XM_010699329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RM15"/>
    <dbReference type="GeneID" id="22573682"/>
    <dbReference type="KEGG" id="lpan:LPMP_161040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160015100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_161040"/>
    <dbReference type="eggNOG" id="ENOG502SM7P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267068at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="604" mass="65648" checksum="39D6E1454FDF8905" modified="2014-11-26" version="1">MPPPPPPPPVSNQHGTPVEVTSVTTESVSSQPTWENIRLLQGLVQLTRCRRRVQPQFETFSLAEPDYIEYNLKGYGPQDLGNGDAVAYDRSARRQIGSDSRGDATVPAAQSLRSAGVAPPSPSAADGGPYHTGPYNVGRDPQPRCQARAAQSPPALPGAVCRGTFSRDHPSPGRGAEEEEWDTSLSGLHGVEGEYSDSGDGAGAAYDREAHDDARYHSKRPPPQHPKGQPHEYSSSWQPSAENSSRRPFTSDTRAEREKRQPGHSPASNSHRLSSDGGARWHSGHDGCGDAATAERQGVYDPRAREYNVESSHPQFIQGVLPVTAQRYERLPVAGANGGPSGTIGNDHNGEVHEGEGFHDGDGAAGWEDALDEWDGDEAAGGEEWRGREDGAYRSHDDGTEGEPSYHRLSPSSSKAQQTYPPQRAALPVEESAPLLPHPCQRFTRGVQWEAANVSTLQPPMLVEGDARRLSRWDNKKRRSKHNPRAFQNRTTYTWVSTNTVTSVMLPPVTVQLVPMPTCAMTEEGHSVDGRWAGPAAAFSPPSPHTLSSASVSGYQQRRSQMEVLDDSAESSSKTRNLVGNSLPYLPRRNKVEQGVVYRSMPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RN51</accession>
    <name>A0A088RN51_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_190260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698021.1">
        <property type="nucleotide sequence ID" value="XM_010699719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RN51"/>
    <dbReference type="GeneID" id="22574080"/>
    <dbReference type="KEGG" id="lpan:LPMP_190260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_190260"/>
    <dbReference type="eggNOG" id="ENOG502SNWS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265803at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="182" mass="19891" checksum="9761EB88B934EDFF" modified="2014-11-26" version="1">MHDSTKMYSKSVQPSSANSANPLDDAMCARVKQERRAALFKMLVWCPHLQQALGAALCLAPPESVSDFSAAVRANMLAGDLCSSARLTPVAGGSWRSCGNVDSFWHIAAPTTSARSNTREGQTAARSPWNTRCRVLQPPSSPSFFFIEPFLFSRCGLQLPTPIPPAFLGLPYVKPRWARHTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RN75</accession>
    <name>A0A088RN75_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">5-oxoprolinase, putative</fullName>
            <ecNumber evidence="6">3.5.2.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_181040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxoprolinase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.9" evidence="6"/>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697938.1">
        <property type="nucleotide sequence ID" value="XM_010699636.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22573994"/>
    <dbReference type="KEGG" id="lpan:LPMP_181040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180013400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_181040"/>
    <dbReference type="eggNOG" id="KOG1939">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3643at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF2">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="5">
        <location>
            <begin position="16"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="3">
        <location>
            <begin position="251"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="4">
        <location>
            <begin position="777"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="674"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="676"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN97285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1342" mass="144719" checksum="4E2EC4B9B27E9537" modified="2014-11-26" version="1">MSITVTAGVKRYPSFRFAIDRGGTFTDIIAHVAQADGTVTQEVTKLLSVDPQHYSDAPSEGIRRILRKYLPDTVAVNGPVDASHLEEVRMGTTVATNALLEHNGERCAMVLTEGFEDILTIRDQARPHLFALNIVKARALPEQVMTAKERIRPVSLKEQSAYASQAVWPSTWVRCGESFVIDVLQPLHTDDIRQKLQAAYDAGIRSVAVCLLHSYAYARHEQQVKQIAQEVGFPAISLSSELMALIKYVPRSTTASVDAYLSPLILNYITSFKANFIHNLAGVQLYFIQSDGGLTSAETFYGYRAVLSGPAGGVVGYAHTCAEDLGATVQAVGFDMGGTSTDVSRCEGPIVHHTVEAEIAGTTVQAPQVQVHTVAAGGGSLLRWENGMFHVGPASAGAHPGPACYGKGGPLTVTDANLVLGHLHPDYFPKAFGPNADQPLDKEASVKLFKALAEEIACDSSAKYTGPAMSVEELAFAFVLVANEAMCRPIRNITEASGYRCAEHALAVFGGAGGQHACAMARSLGMNKIYVHRLASILSAVGTSVTDVVEERMASVRLDLCAEGLTPVLEQQFGELIASATAQLHRLGFEDDHIIAERFLSMQYENTNTSLMIAEDNPQEVAAPVVLSTDKFKRLYLAQYQQQYGFVLSGARRIIIDGVRIRARGTVYSRSEREAQAASAATATQKQHQQPPYTTRPKKVPPQPVSMTRSYFASGWEEIPVYHVDPANGPLRGPALLIMSGTSVLLEHESTAYTNDRGNVIIHTAQVVEQFTTELNPLPLSIFSHRFMSIAEQMGNALQRTSISTNIKERLDFSCAIFDPDGNLVANAPHIPVHLGAMGAAVRWQRDHYGSEWKEGDVMLTNHPACGGSHLPDITVISAFFQEGKIMFYVASRGHHADVGGTTPGSMPPFSKTLTEEGAAIKTLKLVQQGTFNEDGIRETLLAPGKLPGMSGCRTIEDSISDLRAQVAANNRGIQLLQGLIESYTLEVVQAYMRHIQATAELAARRVLQRIAREYGKAGDSSSADMDLVTLQATDYMDDGTPICLRISIQPNSGEATFDFTGSGSQVMNSTNCPTAVVHSSIIYCIRCLVDSDIPLNQGCMKPITVVVPPNSILSPDEDLPVVAGNVTTSQRVTDVVLMALRAVANSHGCMNNFTLGSSDFAYYETICGGSGAGPTFAGTSAVHTNMTNTRLTDPEIFEARYPVLLRTFRIRRNSGGAGRHRGGDGVVRSVLALRDMIAVVLTERRVLAPKGLFGGGSGERGLNMLYVPVPPSGTAPPGVPAWKNAQDMLHDEERGPWMGEEQTTLYHPRNIGGKNVVDVKMGDIITLFTPGGGGCYAESAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNC5</accession>
    <name>A0A088RNC5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_141380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697367.1">
        <property type="nucleotide sequence ID" value="XM_010699065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNC5"/>
    <dbReference type="GeneID" id="22573405"/>
    <dbReference type="KEGG" id="lpan:LPMP_141380"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140019700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_141380"/>
    <dbReference type="eggNOG" id="ENOG502SHH2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="262843at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN96714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="416" mass="45879" checksum="9493CFB7A556E0C8" modified="2014-11-26" version="1">MCVCRMAKMQNRYPAGTKTVGDVLWFSASDTLSGAEQPRNGTARLVPPDMSDLPPRQLALLPTPQPHKPRLTAVVHRRSQHSSSVRSTSSRRPLDEALFCALIMESEAEVLRRLRAHGLAALMDDFQTVCSNLSLHNVRSEEFTFMCAAVLQCPVRPRDGEIVFAFLRGNRTPGGGISVVELLERLRTLFEPLEVLCALQLKCLLETRRLDYCNVALNELERAGAGLRSLLINNPLRDKVDAEWERLVAELLRLQVHFAVPVPTFRLLVRRSARALRSVVRALGWDGKIRWRLCREGEDEVSDDGVQEPLRAFDVSRLTACTVLDLCNEAGVQDSGTALLSAVTKTYNRGLTIRTKSPVAAEGLSPALRATVRATRHASPFGSPNSAADPTHPRFKADLYAVLPASPSCTAARMTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RP96</accession>
    <name>A0A088RP96_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA-dihydrouridine(47) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="3">1.3.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LPMP_170310</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>5,6-dihydrouridine(47) in tRNA + NAD(+) = uridine(47) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53364"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="9">
            <dbReference type="Rhea" id="RHEA:53366"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5,6-dihydrouridine(47) in tRNA + NADP(+) = uridine(47) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53360"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:53362"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Dus family. Dus3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.89" evidence="3"/>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697722.1">
        <property type="nucleotide sequence ID" value="XM_010699420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RP96"/>
    <dbReference type="GeneID" id="22573774"/>
    <dbReference type="KEGG" id="lpan:LPMP_170310"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170008400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_170310"/>
    <dbReference type="eggNOG" id="KOG2333">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="259935at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102265">
        <property type="term" value="F:tRNA-dihydrouridine47 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="14">
        <location>
            <begin position="234"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="199"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AIN97069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="590" mass="65720" checksum="A40B2E0DB0BB51DB" modified="2014-11-26" version="1">MSEVREPGGASGMPVASGHPAIWDAAVSLPEQPALVMPTPESTSRPPITTDKGVCPVKAEYLRPAPARVILDVEGRTRGMNKGAAREHSEFVQGTQRPTWEGEQNFFFGATLQKIKKTVREAKQRQPKQQQEQQRSLVSKDGAVLAETTSVETTEQTAAAVAAEEGELLVVGQKRERSSSAEKAPITAVPALDAATKFNSDEPTARPSHTEESLREVIARQSSSRGLFSEKLVLAPLTTVGNLPFRRICKSFGADVTLSEMAVVFNLSRLQKSEWSLLRRHESEDIFGIQLAVSRPQEAATFAQVLEASGFSYDFLDINCGCPVEKLVKSGCGCGLWERTGRLRDVVENLAIHQSRPVTIKCRIGFDEAMPTLHQQIHQYSTWGAAAVTVHGRSRKQRYTKFANWDYVDQCAQLSSLPVIGNGDIMSLEDVLEHRRRQPHITSHMIGRGALIKPWLFEEIKSGQVKDISSSERLDMLREFCGCGMAHWGSDERGVMATRRFLCEWLSFLHRYVPVGLLERLPQRINERPPFYEGRNELETLMSSDSVTDWIRISELLLGPVEEKFRFTPKHKSNSYEHAAGLDGDLRAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPM6</accession>
    <name>A0A088RPM6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_202840</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698487.1">
        <property type="nucleotide sequence ID" value="XM_010700185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPM6"/>
    <dbReference type="GeneID" id="22574494"/>
    <dbReference type="KEGG" id="lpan:LPMP_202840"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200033700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_202840"/>
    <dbReference type="eggNOG" id="ENOG502S2C8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272092at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="122"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="191"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="196"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN97780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="29009" checksum="785BFBEF7D4A380F" modified="2014-11-26" version="1">MSRSRHSERRESRHERRKESRYSVKKHKHHSSSGSSSRHRHAVSIEKLPVPRDFHCHICGKTHWTVHCDRLQRHPQNYPLMHAERGCHQCGQQGHSVSQCRIKKYLCRDCGGMHDTRDCIFAHIGEDWYEFFDLKTRHVYYANSDESQVQWNPPTHELDTVYWYCSRCQVMISTKFRECLLCHSIRPESKQQEMLTTDSDSESSSSSGSSSTDTSGSSSRSSTSRSNSSSDRSSDADDDEQNASGKPRNAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQ48</accession>
    <name>A0A088RQ48_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_211070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698894.1">
        <property type="nucleotide sequence ID" value="XM_010700592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQ48"/>
    <dbReference type="GeneID" id="22574929"/>
    <dbReference type="KEGG" id="lpan:LPMP_211070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210014700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_211070"/>
    <dbReference type="eggNOG" id="ENOG502S84S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="262994at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028110">
        <property type="entry name" value="TMEM254"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14934">
        <property type="entry name" value="TMEM254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="200" mass="22415" checksum="D7E6CA71F46B2F8E" modified="2014-11-26" version="1">MPSESKKAIDGGHSGVASTAAIPGGPLKRHRLPYRRPLPPFLPLVLLFLLLNYLAFAVEVDDKEGVVLLPEYVHGIARKRDALRQAAAAGQVLTEPIPFNVFLFFEESVMGTLFQVGRFLFRSHFGIQVVCVLAWLVHLFELGVCFRICWSCNASFLVALRYMYCTCVGGFTQLSPLIQARDAWVREMRATEELKSKKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQ99</accession>
    <name>A0A088RQ99_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Calpain-like cysteine peptidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">SMP-2</name>
        <name evidence="2" type="ORF">LPMP_205490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN98040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698747.1">
        <property type="nucleotide sequence ID" value="XM_010700445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQ99"/>
    <dbReference type="GeneID" id="22574761"/>
    <dbReference type="KEGG" id="lpan:LPMP_205490"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200061800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_205490"/>
    <dbReference type="eggNOG" id="ENOG502SP51">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="256352at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000033">
        <property type="entry name" value="Calpain-like cysteine peptidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015232">
        <property type="entry name" value="DUF1935"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036310">
        <property type="entry name" value="Smp-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47047:SF3">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47047">
        <property type="entry name" value="PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09149">
        <property type="entry name" value="DUF1935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101601">
        <property type="entry name" value="Smp-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1935" evidence="1">
        <location>
            <begin position="13"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="136" mass="14918" checksum="8C788DC8D39EFA86" modified="2014-11-26" version="1">MGGSNSTKRGVTYKNGSPAFKGDEVVKGFDKDNGLLFRIVKKKKKGGQTWAFYNDTTQYNMVIKVIFTTGCELTALGSTKLEREKGEWVATVMVMPGRTEMFVEGKIEGFKSNMDAYPVMGDNSGNHLAKVGMKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQA1</accession>
    <name>A0A088RQA1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_211950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698979.1">
        <property type="nucleotide sequence ID" value="XM_010700677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQA1"/>
    <dbReference type="GeneID" id="22575017"/>
    <dbReference type="KEGG" id="lpan:LPMP_211950"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210023500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_211950"/>
    <dbReference type="eggNOG" id="ENOG502SANH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272585at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="27073" checksum="7789E06E6D1C51A3" modified="2014-11-26" version="1">MLRQFEMHLLPRLATVTKRERHSLITGDHRRTSTDNDHSTTHTSGPGVSLHPLLGYASTVTLPAVYSAVVKVTGRVLSLSAAEQENRLSRETFHELLAFIGPLEVLSDEYVVKMFTTLPSYDVDSDTTEALAIFTLLIEHRHHPRLNSNVEALFEAFDADAKGIVPAEVLHSEVLMAWATQHTFGNLRDQWQRLAAVISTERRRNSDMLPLIPSMASRSAIRAALCSVTAIYVAACSLDLDGGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQA5</accession>
    <name>A0A088RQA5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_212050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698989.1">
        <property type="nucleotide sequence ID" value="XM_010700687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQA5"/>
    <dbReference type="GeneID" id="22575027"/>
    <dbReference type="KEGG" id="lpan:LPMP_212050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210024400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_212050"/>
    <dbReference type="eggNOG" id="ENOG502SA6S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267356at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="170" mass="20014" checksum="9FF3F7A98164E210" modified="2014-11-26" version="1">MSASKQTTDHSRKFGFKETREQYQQRKKQEKHLKWTEKLSKENIGKLHAELESLKRARFLAPQQNERKRLVHRMIQDLEATENKEPEEALAVAPTLSIVDSDSDDDLFFSKRTATNDENKRLFVPRSIRRKVEKKKTERTTQQLADEAEKELLTAQHDNDDIDSFLNSFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQI1</accession>
    <name>A0A088RQI1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">T-complex protein 1 subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LPMP_211290</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698915.1">
        <property type="nucleotide sequence ID" value="XM_010700613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQI1"/>
    <dbReference type="GeneID" id="22574951"/>
    <dbReference type="KEGG" id="lpan:LPMP_211290"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210017100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_211290"/>
    <dbReference type="eggNOG" id="KOG0358">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03338">
        <property type="entry name" value="TCP1_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000018">
        <property type="entry name" value="T-complex protein 1 subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012717">
        <property type="entry name" value="Chap_CCT_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02342">
        <property type="entry name" value="chap_CCT_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0346">Stress response</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIN98208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="551" mass="59685" checksum="E672824ADE2EB29E" modified="2014-11-26" version="1">MLAGVGNRAAGGAAASRRKGNESKKDNNTQTDVRISNITAAKAVADCIRTSLGPRGMDKMIINPKGETIISNDGATILSRLQVTHPCAKMLVDLSKAQDIEAGDGTTSVAVLCGALLRAVEELLNKGIHPTQISESFNECAKLAERVLEDMSIKIDIEDRDTLIKAAITSLNSKVISQNSDLLAPMAVDAVRKIIRNNGDVDLRDIRVTSALGGTIDDTELIQNGMVFKQKASRVAGGPVRIQDATIALIQFQLSPPKTDMESTVTITDYTQMDRALKEERKYLLGLCKAIKDAGVNVLLVQKSVLRDAVTAQSLDFLAKMKIMVVTDIERNDIDFITKTLGCMPVANLENFTKDKFGHAKTVVEEGTPSGKVIKIMGVQAPPPSSLNRELFGKTVCFFLRGSNSLMLEEAERALHDSLCVIRSIVKKRAIMPGGAAGEIEVCMQLGKYARERAEGIQTFCMRSYADAFEIIPYTLAENAGMQPISIVTELRNAHASGHVNSGVNVRKGCVTDMVEENVVQPLLVLTSAVRLASEAVMMILKIDDIIMTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQI8</accession>
    <name>A0A088RQI8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_220940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699094.1">
        <property type="nucleotide sequence ID" value="XM_010700792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQI8"/>
    <dbReference type="GeneID" id="22575140"/>
    <dbReference type="KEGG" id="lpan:LPMP_220940"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220012800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_220940"/>
    <dbReference type="eggNOG" id="ENOG502RMYW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271548at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="371"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="645"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="273"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="371"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="659"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="674" mass="76536" checksum="6B111EA396364CD2" modified="2014-11-26" version="1">MYKRTGALREVHSGISVGRLRLAQEFSTMEGWQRLQDPRFDEYVKEKRQRQYFDAFDQRVERAFRVAKRLHKAEVMNAFKRKVKGSSEGKWTAAVMLEVKLAVEERLRWLREVWSQIDADYRSGNAEQQARAAREISDALRGEPGAYMQWVYERKRENRFAGPKEKAAQEAELSTAELPEVTDDEANRYHNLSLRMADIEHNVKTCFGIAGQQHWAELQAAKDEAYEQKLDTAAKVYEKLLDQSARFDESRRTALLRSNVERVHQAQVRFKASMEMEKEREQLVEAHEAMREERKQQAKAERIAILQEAAELRRSGATPEEIKQLARQRQLEAHARRQAEYQLQERESLQQKKAYYLDLIEKFKDEVEMREGQEMLKQQESDARPQRSHRNVESSGAPKLNAFGFMDADRLDDPAESLLTASDAMRSSATLPENSAGRAAASLRRSEAQQSRRKALWDIVEHDRYEDPFMTIHQARLDAAATYDPLYAKHLAPTLAQGKKYTRQGFGELAAGGGMDRHVFKASARTVRPYQWGLSSNVVHDVDGDGSNDYFMGLHWHVRHPDTGDIDWRYEKKAGGAVFRGPLLYRMGAEREAGESGSSTMDPSTATVRRFSPLATTSSKAALKAALPSPARQAGVAAPLPVVRRGDANQPLSGCVTPNAGTLTAQPLPSWRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RR29</accession>
    <name>A0A088RR29_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_201400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698341.1">
        <property type="nucleotide sequence ID" value="XM_010700039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RR29"/>
    <dbReference type="GeneID" id="22574349"/>
    <dbReference type="KEGG" id="lpan:LPMP_201400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200019200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201400"/>
    <dbReference type="eggNOG" id="ENOG502S62K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="250181at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="879"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="879"/>
            <end position="895"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="932" mass="102236" checksum="F585E7F817D1EB8D" modified="2014-11-26" version="1">MMEPRSHSRSAKSTHSSTAPAANADRNKSQTTDAKLSSGVSAPASASGPRPASSSSRLRSSQRKGKRQVSSSFSPARVRGTNGSGSTVMEMSKITANSLASINHSLFTQAKLTSKQIRSRLLKEYLQAHSAGAHMIENQWAEEYQTIWQSFLDASYTPQSREIKRLLGHTQLVELTCQQKLQHAHTVTYCALSGIEQLVQRITDAGTCVRNDTNVLAEKPDLFLGPTDAKELCQHAMRNGSAASATMHVRGNPRPEVCGLDVVLSDPHPLAFQISQADHDERERLSRLFNSVLDSIGADSEERSVGGSTSSMYGTMQAASALGTQSMTDCPLPMPHSRNEEDSARCTECSSPTPPSTRWQSRQDDLERVEAKRDDSSLGNLQPERTQYVRDLQTQLDALGVGFVQLMNRIQAQHQRYQHTIASQQVVLDSQATRLKLADDVLRNTVAQGQIEALSAVAAAKQLSLELRERMEVSERSMNAALQALIEQSAEVCFDKDVLKEYDSRTTEKENCLCAFMTRMERQAVEQAEVLRKAQDGVEEIWQLREQWLLQLSSGAASEAGAILREPQAAARNVTPLPPPYGAKLKECDRATLLAFLERLTMHCPKATTHVISALDEHEAFCARHPQEAAASREELARTAAVVQLLQKLDEEGRLHCSAHHTNEALSVRLRRLVEQHDAYMDFNETYARALVRQADAERRQYAPDTVAFFDFRTPVPEQVSSVASRRVAPVRVQTNGEDHSGATSSSAAALYSAAELKTNLPALPKMPYLSIWTRKQQELRERQYAAGAIIGGASSSTVGAVVGYLERHPSCLAAPTAATRVAAPTADLFEATPSSTRSRLHTAISASALTCVSASTPPPPIPPRKGLASYVISTCGSTTENTEGSSATARQQQPPKEEHTVTKEKRKPLMLFRGGDHQFIQWESEVLVQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RR31</accession>
    <name>A0A088RR31_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_221440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699145.1">
        <property type="nucleotide sequence ID" value="XM_010700843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RR31"/>
    <dbReference type="GeneID" id="22575190"/>
    <dbReference type="KEGG" id="lpan:LPMP_221440"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220018000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_221440"/>
    <dbReference type="eggNOG" id="ENOG502QVS8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269394at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="620" mass="69222" checksum="5D60D54491945EA4" modified="2014-11-26" version="1">MSATASSALRTATASPGTLDAAADLHTSEAVKETFKLLVRRLVLVDTAEDNFQWSSRAKQQWGGGKPLFVSVSNKFKEHGSTSPRNMMFGHPQQSQQQSWSGIEWRESNSIAVPLEDDPVLMIEVGVLRHGKKNVLGLGIMNTQSILTENRQYTKFTVHVLPTHISIDASTVHVVAEVEIYSSLLRESPDLNFTPLEYNYGTVRVSTVDFYYPSFFLTGTGEYIVSNVLCAMNMTEFSSLAMQLVPLRSSASYIATEPSQVITVRPQQRVYFSATWNLTHRACMRTLEMQLTVNGSQKPSAPVLIKVHNQVPQTSSNTDVPFHYWVNTTCITNRQMLPSQELPLIHAVLPVYRFISRSAPIDQREGMIVAFDKDKGEHVLVRANGVPVTMGKLYGSDQQHQRQQQQLQPQLSMQKSGTGTYALSRLENMNFMGGGDMVPQFDFDVNASFVVCDNHVRNPFSSRGPLLNLSQKTCLCTIALGPIRGFPMVYEATTGLLPSFQVSVTLLDQRGWQVVHGETLPSYHSASGSLRWAEQLVLRKWPGATSQQFVRLNLTEVRPRDGDETPIGAGLISLPSMQRLYTQNPLSVAFYVYETYSLYDQLSSSSLLMKDVNVIFSELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RR67</accession>
    <name>A0A088RR67_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_220970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98390.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699097.1">
        <property type="nucleotide sequence ID" value="XM_010700795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RR67"/>
    <dbReference type="GeneID" id="22575143"/>
    <dbReference type="KEGG" id="lpan:LPMP_220970"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220013100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_220970"/>
    <dbReference type="eggNOG" id="ENOG502RSJ1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268044at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98390.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="788" mass="82998" checksum="0DDE13DE1897EAA2" modified="2026-01-28" version="2">MRTVLQTTTTATPPLLSQQQQQRQHHQPQQSHFHANVIALRSLQHRMQLRAEAAQPSHAGPSFHSHSASGPSASSPQHRHCQRCATPPAPLSSSPRKLTTTQTAPAIPGVPFSAWSPQLHAAVLRVADLGEVDITAGACCTALGMVRRTATAQLPEMCRLVHVASDGEGTPAAGRSPGACGACMCRRCDCLNRPYASREEQQHRNHRRHHSRHRKRHASSSSRRHRNDSAVPGPSSPGPPKPSTATTARLPSAIPLLAMPANTSPVASPFRDQDVLERIMAKYRTPPTPLAESAQQQQQPLHIFVHCGCDQTGAPAPATAPGPAKYTAAVASPPSTPPPAASLPPPPPAASVPPPPPAASVPPPPPAASVPPPPPAASVPPPPPAASVPPPPPAASVPPPPPAASVPPPPPAGAGPLVRSPLLVVAPPPSASVPATPPVAAGPPLTSGPTTAPTNSSIDKERQMLLEKADKYVWQLEQEVQHRALHYNVVLQQLAEEEARSTALRHDRDTLLALNSGLQASLGYTRGNRDSRQQHQNGSSTPSSSTSSRETTPTTSPQGASESTMNKPPPSQQQQQPARRLPPAVESVYASLQTPADASVAPVLLPAPPPLATSAPAPTATAAAEGRTSATQEVLQHVLLEREAALQSSPRPTAMTAATSTTGSMPHLGYSDGLRRYVDFLYQEAEAGAAHVRRASLPLAAPAAPAAAASSLAPSPPLTAYQLPQYYHTSPAGVGTVLSLANQAQVQQQRQRQLELEQLRLEVAVEGERMKTDMQRWRAYLQQQQQRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRG5</accession>
    <name>A0A088RRG5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_240430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699384.1">
        <property type="nucleotide sequence ID" value="XM_010701082.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22575452"/>
    <dbReference type="KEGG" id="lpan:LPMP_240430"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000010600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_240430"/>
    <dbReference type="eggNOG" id="ENOG502SJ60">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="263283at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047141">
        <property type="entry name" value="Stealth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24045">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24045:SF0">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-1-PHOSPHOTRANSFERASE SUBUNITS ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1364" mass="150905" checksum="20BE797C2EE67971" modified="2014-11-26" version="1">MTVVTVKYLYANYPTQCNLLILLGSIALLLWARWQRWAQRLRMVARSRMREARPVLQAFRRRPLNWRWIAGEIMIMLANARPLSVTTFSTLLVVHCVLLGIERHFSYRNAPNNIQLWTYQETHFDLTTMGPSLVSPVHDPRSLSPYGPRSSRTLAHFCGRPTASSYDGYTGAPHAAYIHHDVERDRYVVRTFGRGGTRVDERRRSGVGRSTYEAFCAAPRRVQLGTPLAPSPWLDGEANWQLGDAGAAPRHAVNGAFSFAVQPLAVPHAAAAAVASNATASRSADADFTKADQGLRTHYRRYTRDELLQRHAHLDFIYSYVNGSDITRGYTKPFAKTWECWNMIASVQLLWGEMQRAADIGADAPPLAEDAFSRHIAELLFVSSSSPCALSQLLADVNAGKDAMKRVEASLWWAATHPSQPHIKGAPPPPEMALTNMELLHALGADLESVKPDDIDADCDELRHGMRGLLLHTRSWHRGRMTVVTPYGNVPLWLNQSRNFFMRSLYAAATAPTARAEAASGAADGGDASVLGTAEARFVREAHTGKLHYTRIHIVDQRALMPPAPLTTANSYVVEPFVYRLRNASSVFIYMNDDYLVMKDVDITDFVNEFGGPLLRIRKSDSMEYYEANRDYFRRGLVFNTMLMHRDLDRTPADLEELVQPATAAATLTSMEGEAVVVQRGVVRASWAAFAAAVDARSSVATPGGSAQSTSTACARSSSAAVCAWADCAWGAPAGAVARGACAMPRVSAKGEPAWAADAAGTFALVPAPPTKPGSGEWTWTGHVQMPALVHWGRRVLDRVTADLIAPRYYLETETIALTKVEHEPIVLQMNSSSITEHLTGLRNAFASLQGDTQDAPKTKTTATYLLRMLMHTISTYEFPTHRIFKTQPRLRKYRMRLDSHAPYAQCRNMWGYIHKRYAPDLNLNMLMMRTRTTMDLLPPSTHTAHMLRHPWAASSQYLPYLIAKQAWRMQRGAGLSPLGSDASVFPAVDVALDNEDGCAPATYITEAEKSARYHEFRDDVSWNAKTMKRIRSYRDKKPFTNINSKFSSNEVGVTLRNFLEELFPTPMLLERQWSSALDSGNGTDELRVSSSVEEQSGAPNLQFMHLNVNFERLMRLPLILVSNDEEGFCPLLRSLRHVLPDFSGQRVVHVLVPPADGVSLRAARADRRHPYREFLPVARCSLSADRLRRVTLPADSSVADVVVAGLRLAREGVAAGLWEAPALVELRGRRAVQALVLDARTLRAGARGFTELSHALGVPAELLAYEDFAVRLLDAAAQSLVRSPTPAEAATVAAAVPIKEASRRNGAATADDFAASVLVLSEAEAEARHTHWAYGASEHDLLSAMPLPYGKVEDMEAAVQWVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRJ3</accession>
    <name>A0A088RRJ3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_231440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699300.1">
        <property type="nucleotide sequence ID" value="XM_010700998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRJ3"/>
    <dbReference type="GeneID" id="22575349"/>
    <dbReference type="KEGG" id="lpan:LPMP_231440"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230022400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_231440"/>
    <dbReference type="eggNOG" id="ENOG502SH93">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273832at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1190" mass="126732" checksum="CBFF4F204F735A70" modified="2014-11-26" version="1">MPLVVQQQYQHRTKPDSEEEGRITNAAAPAPVSAPQRDALASIGTTPADGAQTRRSSSSDYSHLLTLAQPQLTASEKTLFALFRSAQKERQLVRLQRSTVWPERFIMEGSGAGIGVGHDRRPSPFTDPLLHLRDLEEPCLLIPDTRDTFVSLGLAVGLHPTTDTPASPTSACASLAGGSAAARTPPALSPSSPASDVGLAAHAAATADSTIMDAFHIGLACTSTHYRSDYTSLPEHYVLGVPTALLSLLRSNSSISKHEVQKRKCSADAWRSRSQTPVDLSRWLAFDMATSQVLLRRRGVPSTNDPLVPTWVAALESQVFLAHTYSFDPKSAYQAAALQAGVPVPPSARSAESSTSASEASMPMMKMTSPPLYSLFFFTVARGQATANSRVSPIHAGVLYPSCFFSYMSEVPTTQHLAAEMATVAAQFPRLNHAGDSKPSMLMSSAMGAGPVDNASFFVPISGKRLRLGASASSSTPAHLWTAQLQSRKLGAIAVSALAPSSSPYVKQAELMTTGCRPQADSSALRSQGGRDSWRQSVVCQKMSESFRIWREAVASRASSLPLRTSTGATASAEDSAPSRAPPPMADGQQRLPAPLPRPEHPQQINKLMGSVPWPPASCEHGREAGHRSRLEEQLDAEGVALISDDGTLSQEWSAGFRFGRVAIAVAMPLLFPISTVVTDAAAASNPLPAAQQGLQTSGANAAINAAVRVIDAPLADALWSVLYAPVAATSPSPATLSGPFTPHSSFFSSTVTGTANAAAETVMASVLPMAEDRLMLARERVLLPFLLHQPRWVLPWSDLHGELPSSSPPVSDTGKGLRSACKSNGPSPVNVCPSLWRLDELEQICGWRCHRLPFNDAFGSFSGLLIHDLYIMIGRKTSAMLPGPIPATTLRVGQAGKQQATLSPVVLLNDVVYVERVLLPAMRCFAANTCTWVEGGLCVYRSPYEALSAEMCYEAEGDFTISKKPSTSSLSRVAPQQWDSQTSCNDEPAELPAETAVEVALHHWQLSLWLKQLQRTSHKLLRRWLAECHGRTSLDPALEARVRRRTGGVPAACLAFFVGSCSTAPSMLSSRASPAPYDGGSGGGDDHDDLGDFTAVAASAEAIEKGLQRLLSLTPDRIAVVPLLDFVVWGALCSDFAAASMQRLAHAADGCRAALDASADGLTAVKYCVRYPRHLCCHGGRGATVALLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRL0</accession>
    <name>A0A088RRL0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_203690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698571.1">
        <property type="nucleotide sequence ID" value="XM_010700269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRL0"/>
    <dbReference type="GeneID" id="22574580"/>
    <dbReference type="KEGG" id="lpan:LPMP_203690"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200043200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_203690"/>
    <dbReference type="eggNOG" id="ENOG502S9I3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="262418at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="270" mass="29702" checksum="3FDC58C995784FE3" modified="2014-11-26" version="1">MSATSFQLSDRTNETPSSNASSGSLPLQSAPCDEATRATCHAKHLHNEVQPHLDVIHRELEELKHRRERLEAQRKELLQGKRGSAEGQRTGWISGSVSTHAGAARTNSTPGLTGAHPRSEMESLAACPASHGSRERHSKSSHHDSLLLAGLRPIPSEQERRRMLKATPHLAIKNALRDAAQQDSTLLMGTFLLEDNPHTCTFSRERRFRPLLGQSGKYFLSTDFAADQCFNRSHAHAVTSLKAWGSSSQTPGPGAYTPRYSKLSRAPRAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRM3</accession>
    <name>A0A088RRM3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ family chaperon protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_203850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698586.1">
        <property type="nucleotide sequence ID" value="XM_010700284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRM3"/>
    <dbReference type="GeneID" id="22574596"/>
    <dbReference type="KEGG" id="lpan:LPMP_203850"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200044600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_203850"/>
    <dbReference type="eggNOG" id="ENOG502RIQX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="240298at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="29"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="255" mass="29338" checksum="28939A6EBD339EA7" modified="2014-11-26" version="1">MLRRSVVRCVYERFEGHISGDKGHMTLQQACTIFGYQLDEEWTKKDIRKRFQKLALRFHPDKGGTSEQFLTLKEAQHLLLTHRRDRGADRGAKGAKGEGDAGGINFRRMNYDNLTNTIHRQTADNPEYRSFSLQDFAIFLVCFTAAALYYFYKTYTTQMQVLRSRWSYSEDAIHADYKGKAPSESMWHPWMADAETRDRMDDIAILQGSVRQELIDEKRKVAPPTYMPWQSSGPFACHMAPARAPEVSKDAHASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RS02</accession>
    <name>A0A088RS02_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MORN repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_205270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN98019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698726.1">
        <property type="nucleotide sequence ID" value="XM_010700424.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22574739"/>
    <dbReference type="KEGG" id="lpan:LPMP_205270"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200059400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_205270"/>
    <dbReference type="eggNOG" id="ENOG502S7PK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266722at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="60"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="492"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1046"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1545"/>
            <end position="1566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1604"/>
            <end position="1625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1756"/>
            <end position="1844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="252"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1055"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1612"/>
            <end position="1625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1787"/>
            <end position="1796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1808"/>
            <end position="1821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1822"/>
            <end position="1833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1940" mass="203526" checksum="FEDECE60CD3E84C0" modified="2014-11-26" version="1">MASASTSLQQSLGGVENVSLKVRGTSFTAVDNHTPPPRVKYVTYAKLPCKCAPGPPIAASPSLRPRAASQATVVSGNPLLTAPPSLPASASPPPSPTTETATQLLPPQPTSPRTASVNEKGDSPFQAAQGFLFASGASLLSYANPALYFSNTSGLDASSGSGGTNTSCVEELSEEVQRNLLTSSTVAAALKERYDGVGATAVPGSSSIRNSSVDWKKIDWVRQQCRYTGEALLKSPLKTAHDSEAAARRESASLPTDVAAATAPPPTSDASSFSSPTATPGSTEVGERSMGARLMQSLLYPFTQPTAPSPSTIAAPVAPADNVVADTVVPHGDGVMTYLLYCKPKADGYGYPTGGLSSETAGVGASSSPILPVAPFLSPDLIPTAYCPPLTDIEITTAEVGLAPSGTVAATSAPPVPHLLLLSLIVYEGTFVHGRRHGRGRLTAYGRMVLECTWSEDVPSLGVPWLISPAANSTDLPAPTLWNVDAHVWTPTPTKPTPSVAQSTRRGPRPRTTATDGATVDEARRCPSSASSGTWLVRTSQTYMGSLMLATVASKKLLAKMEACMRSISSPLGAQVVPDLHGTRYVALPVPHPRSSSDGADLCDAFYGLGWANHVVLLPDGFGEAHFQADGGLVFSAPPPPSPMLTISALGGPFQPPLWVPETSSASSRTYTSFSSASPCWQYCGQWSAGLPHGFGAEAVRLTDPTAASLAFSASTAGAGPPQYPWRSLFLGQYVKGKQCGPGTHHGVQGSEATEVVLCGTWPRHGRSSTAAAPALHELEQTTANVVLLPLSSCTGVIRAAGVGAITAAASPSSPLVISSSFFSLQDARWSDNGTGDGRNAECSSSGGGFFPLAKLRQSTAALSGMWEPLFRVVDDVVARQSPSLLFGDDETGGRAGGECVGDKATASDASPSNKALLWQRAYQLMDSFVTSPTCVTVLSTFQACFAFMYGADVTATATAAAAAADSTNGMTPSGSKEATLTLLQLLESAAAVAPSSSSMAPLMGYPWCPPHSWCAMAHLGGPSVPLRGTQGGPNFAGCLHSGLSDGATHRHSPPTASHLGTQQPSGFSRTAYSKKGPNSASRRPPLSTAAAALEPFSAAHTFTHAMHTAAALVSSLRLRLLSCFAVYPNLCEVVMGDKESEDKIVQYCWDITFGYVGSVLVKKATAVAVADVHLVWELLGLKSERGRKETLTDYFVALRRCRTLTRADMVAVLHPDGVEACDAGNLSSLNEYARRFGELLELHAAATLSTPLRCTPAIRVSNELQTMSTLLSELHALLGTAGTISGRVKCSADHLSGSEVEGAAMTTTFTLAQQEALLRWVLLSATMGQTSAVSFASCSVAGRHPFAFLLLGHFLFSGRVIPAYPILAGDSCAREGSNNSGYPSRYGLLLLLADMARATRELMHTYPSIRSRALLSSSRATMHARMTSVVCPLDTLALKLEYALSPCAALHLCASSHVHLISGAAVGVTSSGLQVSGKGGPADETGGTALCNAGAPMGSIICIDMQNLSCEAQQWCRRELTDHLTVPLLEARLQGYWNHLTPSAAQHSSHHHSAQVDGSVEYRRDDASPPSPLMRWLLACLQSVLSAPFQPQPVVKTSIGAAPADSAPTEYRTSQSSSPTPGQFCSTPLPTRYTWKKFISAVFFSPSEREEWTSAHNPTITAAARALSLMDSCYVTALAYTLRELAGIELELRARFVFEDEDEDEEKSSDADRKASCRIGDVGERRGVSASATAPMQIASLNQWRRERKNIFLSSSSSSSSIAPSPQPNFFPDSGVPRATEDAHTGDSSSRSGNGSCHGCLPREEATATSTQSSTPTRQRCPTSQLPSTQESPCDGPPRANGRPWCQSVAAATSAASPLTSDPVGKEWELTLVLRHASDGGGEQETTNPPSNAFFSTLTWEVMEQVCSAVLHQLQVTAQVGDAAETEKLKKAKAAKVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSA3</accession>
    <name>A0A088RSA3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_210230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698811.1">
        <property type="nucleotide sequence ID" value="XM_010700509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSA3"/>
    <dbReference type="GeneID" id="22574845"/>
    <dbReference type="KEGG" id="lpan:LPMP_210230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210007000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_210230"/>
    <dbReference type="eggNOG" id="ENOG502RURW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="724" mass="78716" checksum="9E3EECAADB2BEF22" modified="2014-11-26" version="1">MSSSRRDVLFFGSIAVSIIGHKVHDEAVAAQLEQQNASIKLHATASTPYAKTEEVFGLVSTSPLYEIRSADSKASPAIPFTAQRGASHPRHHHQRAAFLPVVLELSPKAAVEEVPSIADQDGALLQLDSPMNDADPAPSYTSASLRIEVGVSRSGGDATVVGAKEVFLPSLNYLASRDMCTVVRVPVWSDTILKSAVGEVNVAELHRRSSQIQIADDSSSSSSVVVLGDGRDRNGRGDAVSGVALSVYAMVRVISLAEKVRLVCEADDAVRRLLDLPDPARKVSLALTQRGEAPYGAMPLTELYKHHWHFFGYYSNTIIKHSNVVMQRLAEAPRQREAEASFPHRWNALTVVDLRPTLLGEDAFAPLLVTLAYCPNLRAVYADGNHLGDLTCARLSVLFRRHRYLSCISLSKNVIHEAGGAQLLRLVRNNLRITSMPCQGNFFSDEMRSRIEEVARKNASVIAQDPLNVFSSSYDYLTDLSSLPKSLQQQGLRTWAMLSAAPVGDVDVMVRNFTTSTQRTLGDSPVAAMERAKAALRSRESLSLIPPAALAPLLSEVMRTVSVGVSRVLPDPLVRSLFSDMETVVAQEQKQVEAQRRDELAGGIRDASFLPPEVCDAMGGAHTPAVDSENMYARAFVRIVVAALRGVALRTPWAEIAKVLEGIGRVHRDLGVMPEDYWLAVHIFMTSLRISCGAEFYDADHASSFLALLALAVRTAAGTDAVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSZ7</accession>
    <name>A0A088RSZ7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Proteasome component protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_252300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699800.1">
        <property type="nucleotide sequence ID" value="XM_010701498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSZ7"/>
    <dbReference type="GeneID" id="22575878"/>
    <dbReference type="KEGG" id="lpan:LPMP_252300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250025100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_252300"/>
    <dbReference type="eggNOG" id="KOG1464">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="1">
        <location>
            <begin position="251"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="439" mass="49661" checksum="2CD9A6FE5C6CBEBC" modified="2014-11-26" version="1">MEDDYYYDDDGGYDEYYDNSADEVVDVDPLEVKYVDGKSFMQSNVGESLRCLQEVMTEDNEHGKWTFKALRMLARASRIAKKYDAMTDYYTRVVHFTHPDIGAAAVAKAMLKFTEESQQVPAEWRGRTLHVTLEVATAQPESYRDVIVPTLLRRATLFVEEAKYEEALLDLQAALQKCDESGVTTAQVNTNSVYHIRSLQLTVYRKLSRYAELRRAYYELDRVQAALPSLRMIGSVMESAGHLFLHDADWAAAHRAFSLALRCHTESGCAQQYSVIKYIVLAAIMDGTPTDVFAQEETLANHSSVRPVRALWQAFIALDISTFLHVLRAPANAVCFTKDAEFAPYVEPMMFQLRTNYLISYSKSFGTLSLLELGARLQLQEQPCKELCTSAILLGLIDARIDDSRKLLLFQRASRTVPSSVAVLRDLSGMTSELCCMYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RU78</accession>
    <name>A0A088RU78_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Multi-pass transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_241820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699521.1">
        <property type="nucleotide sequence ID" value="XM_010701219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RU78"/>
    <dbReference type="GeneID" id="22575591"/>
    <dbReference type="KEGG" id="lpan:LPMP_241820"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240025500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_241820"/>
    <dbReference type="eggNOG" id="ENOG502SJAA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273576at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="358"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="404" mass="44045" checksum="49766B10ADF9513E" modified="2014-11-26" version="1">MQRSPEKRTRCRRAGVWTASSAVVAVLCALLCSCCLAGTAVEQEPLVLHTSLVDLLNAENALWTVSLGTLNAAGQLAEWTAMREVRVETQPSESAASLLFTLPPPISLKHRIEDAEEGKYDEEGAATEKRGAMPSDDVSTRTHRRKSFHGVSCEEYRTGGRGQQGAMQGRCFFLRDDGEDFFVRYRVKSPDTEEAKSGGEEAAASKTTTAVHRHRPRRAPAKASASQQAKTSSDAEASGTEPWTVHSTSASDVWTERILPYGGSAAAPAERGAGATEEHARIGDVTIDEYIRELPDAHRSKKMLLTFAMLMVPKSTALAVQRSDDVMHVRLECLTGAFYEDMMRRSTAAVKASHTRVFHRWVCPVLLVTAIYVMVSATVRLVAWRKASLGSGAQLIVGAAKKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUQ5</accession>
    <name>A0A088RUQ5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_282590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700599.1">
        <property type="nucleotide sequence ID" value="XM_010702297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUQ5"/>
    <dbReference type="GeneID" id="22576704"/>
    <dbReference type="KEGG" id="lpan:LPMP_282590"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280032400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_282590"/>
    <dbReference type="eggNOG" id="ENOG502S81T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273452at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF5">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="2">
        <location>
            <begin position="56"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="399" mass="42536" checksum="F1FBA3F6ECD99920" modified="2014-11-26" version="1">MNAGVLACAHRVVNHVCAVVSAVVTRELSIDDMQCSAAAKETALAANDAPTAARRELHFSAVGHSMGGLILRAALPFLIDRIEGTYGEQSLGFAVHWDVFCTLATPHLGVKNMMSNTKMFLGQHIGCYLSTAIADLFCKSSVVSADLVSRDSLAAWARFKRRVLLSVVNDETVLMHSSSFVMPLHILKRVGAPLPTAEADLTDACSKTNAGTHHRQADCSALHLARLGIMCASSLEELRGNGVLLTEISPDLWPPGVLPEERALAEHILRDVGPLELHVVDFRPRLARLTSRDASHGRHGGDVALKPGIVARGMMMLGVNRFSHSALLCKWPFSYPSLFGFVLEYVASDLILTPLSSAVPAPTPQEALQHRSATSSGSPTVADSGEGMASAAEIASPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUU3</accession>
    <name>A0A088RUU3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_281550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700495.1">
        <property type="nucleotide sequence ID" value="XM_010702193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUU3"/>
    <dbReference type="GeneID" id="22576600"/>
    <dbReference type="KEGG" id="lpan:LPMP_281550"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280021600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_281550"/>
    <dbReference type="eggNOG" id="ENOG502SFYK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="242919at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="674" mass="75124" checksum="CC2CA270834CDB09" modified="2014-11-26" version="1">MEENAASQPLTVYHPQAGLQDTPAQVDLSSLFYDTSVVDITLSKRKFTKDDDDGSFMFGQVPRGHMKREQVLKYIDMDELTKASELLEVPDAYTYPLHRMDTISEAIMRTMQSRVLMCKYASLDDFYTMKRHIGTDEDVMRATLPGNSIYFQFIHLGGAKDADGPTSSSSLSSHHAKQQEVKAVRDAVEKILRRYVCRILEPFPNELAIDVTHYATYLPLLNVSRRNVSQVLKDVEDYIAKKPVNKEGIAGPPSEKEIEPLTPDALAAEIARIIRREVLTRHPQSASEGSGEATRTTDAQETPSSADAASTAAVRVCIGVATSPVLAKIACDAEVLAVMAKLRDEQAASLTAGKGGGSSGVPLVSIRSFHRHIRSMKASRDFMASFPVSRVPVFTPAFVELLKRIFGIVTCRDFYEKRYHLYYCMSRETAHACYAAAFGRMYFEEEVVTSLVAPENLRRSIAPLEFMASNRISIVNEDRTDYNVTMRSVIIGQLRKQLGNVGCKATQVPFGRLSTDDAIHRTAEAAMRSLHRYMYTKGFTYAGVRVTLHRSNIDPVMGRFEGETTEEAAVAVLHRVLAKLLPYRNCLEDSTEGQNTARYITLAVFGISLIPMVPPIMIAEAKKLEKLYFTAKGFFLLYQGRIMRRNEMLATGGAEAKRSGRKRKPGKVDSVVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUV6</accession>
    <name>A0A088RUV6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_280070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700352.1">
        <property type="nucleotide sequence ID" value="XM_010702050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUV6"/>
    <dbReference type="GeneID" id="22576452"/>
    <dbReference type="KEGG" id="lpan:LPMP_280070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280005600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_280070"/>
    <dbReference type="eggNOG" id="ENOG502SB84">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270825at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="528" mass="59813" checksum="095B5C99DA5BB9E6" modified="2014-11-26" version="1">MPRHTSVENMSSTTRELRRSASSIATELWSPDELYKADPQVDVLQPILSPLEVDARQFCAFRMSLLLAPFEVLEDYWAPQGEDTDLLVDYGVFDVTCREMRRDGRPDVSTTGIIAEQCKTTSWFRFTSTLSRRSFVVDRSAVHVQTLVEALRYSFSHLLFPTDSETSEGACNVLFQFIVHHWSRLSAYFPLLYFLFEVQERPFSAFYKQLATLVQTRKANDAAACDALRPKKSATMFSWFSSKPKEAELGMMDKLEIISTLKSMLPQTFEKRYMVVLANREQFRRMQRFSGEYVASLTREVSAYQALAEGFVVHPLASSAVEGWYSSSALEAMAEENAAVKQALTAVQQFVLRKSSLANEFLLSNVKAMLQCEYEISVIANSLVVFYEELVMRAKMVSENTMLLSGEVPLPVGCEASTRAESLSNAREVNQRYTLEFSKRHQQFDGEVVHAEAVIKTHMRRLCIFCGHVVKTIASYTNAEYYEEYLRPLAPSRTDGVTGYYSSHALKACLGVKEGEEESTFAIDREGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUW2</accession>
    <name>A0A088RUW2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_280130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700357.1">
        <property type="nucleotide sequence ID" value="XM_010702055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUW2"/>
    <dbReference type="GeneID" id="22576458"/>
    <dbReference type="KEGG" id="lpan:LPMP_280130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280006500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_280130"/>
    <dbReference type="eggNOG" id="ENOG502SA10">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="258750at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="182" mass="20902" checksum="3078BAE503D98AAC" modified="2014-11-26" version="1">MRVFRISVPLMCFFYHFVVMIVTFVNYIIVVRLQDTPQVLRSAYLVFCIIEAMAYAAGAGPLFVYSYKYGTTSAARLSRLLCGIAIMFLFSSVPMLFMEVAQFLSFDYQFRHPLDGTVFVLHGIAWIFGGCITWFAYMRVVAGCLQRWRGPERQIIDDSGNIPSKDVQLHLVKRSQRQPKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUY6</accession>
    <name>A0A088RUY6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tubulin-tyrosine ligase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_290260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIN99977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700920.1">
        <property type="nucleotide sequence ID" value="XM_010702618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUY6"/>
    <dbReference type="GeneID" id="22576790"/>
    <dbReference type="KEGG" id="lpan:LPMP_290260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290007700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_290260"/>
    <dbReference type="eggNOG" id="KOG2158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070740">
        <property type="term" value="F:tubulin-glutamic acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241:SF147">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE TTLL7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005413331" evidence="4">
        <location>
            <begin position="22"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN99977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="634" mass="69945" checksum="7D88213CBFB36627" modified="2014-11-26" version="1">MIVVSFAFLSTCGLCPYTSLSCSVVPSRYRGHLALLHHLTHVQEKRHARMYHAQQVPPMSSTGGPGREPPGGVVIDCRGTRYHVVRAAARMVGWTVYDTDSTDRVPAFFPDVPLEAVERVTAPLHAPQVIWVDKSVVSSRVGGLACYQRLNHYAAMNVIARKALLFRRLMQLLRLQTKEGAMSERRGCGAAVDCANCDQSPLERFLTLAVPASFSSLTDLGRLAAFQRELTVRTDPSSEPRPVFFIVKPNTGCEGKGIRLTTAPAEDLTEEERTDKRRECIVQLYVDRPLLMGGKKFDLRLYVLLLATVPQQLSRRLTVTSPAPSFSLPVPKPALSECRGGLTEVPRDVQGVELFVHQEGLVRLCAEPYAAPTEANCCNVWRHLTNYAVNKHSSLYVPAADGDGAEPHVDDRDFPRQPAAPVDQEGCNKQSLSALASLIDSLQGPGGWLSVRRRLDECIALTVLSGVEVLRRELIGAGGTRGYRADGRSCFELLGFDVMLREADLHPVLLEVNHSPSLFCDTAFDFAVKSTVLRDTFRLLETHIPPWGQHEGNPQKYEACMQGDTKAWMEEEADILVRGAAAEPFGFRRLLPHYSAGCSTGGAERTGDGEAIDDWLPAERAAQQRMVELSRRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVS7</accession>
    <name>A0A088RVS7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Flagellar radial spoke protein-like, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_290650</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700673.1">
        <property type="nucleotide sequence ID" value="XM_010702371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVS7"/>
    <dbReference type="GeneID" id="22576829"/>
    <dbReference type="KEGG" id="lpan:LPMP_290650"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290010600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_290650"/>
    <dbReference type="eggNOG" id="ENOG502QSU4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272202at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001534">
        <property type="term" value="C:radial spoke"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035082">
        <property type="term" value="P:axoneme assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060294">
        <property type="term" value="P:cilium movement involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006802">
        <property type="entry name" value="Radial_spoke"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13159:SF5">
        <property type="entry name" value="RADIAL SPOKE PROTEIN-LIKE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13159">
        <property type="entry name" value="RADIAL SPOKEHEAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04712">
        <property type="entry name" value="Radial_spoke"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="67"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="420"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="571"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="420"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="583"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO00016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="593" mass="64649" checksum="3C641BB9E80B6411" modified="2014-11-26" version="1">MAGVDEHQIRQSALWGHMTQVLAQVIRERPANAMDALSAASNHLLSGSAVPPTKGKMYVDPRPTARAEAPIDSFTSTRWAANTNTALAPPRPPRRPRRADGENDEEEEDDASANAGLDGQPRIDLADHPGTLSDVVMEQQYFNMVGLGLPRVEAYRLLVGLRQLIRSEPLSSVRFWGVVTGSSYDYYVAECQVDAERMQENADMNGEGDEDGDMEEEEEHAPVSKIADVLCTVARGRLARRGPRPSTPAEEAGTGLNAMCYYASTSADLTTWTRLPDVSPHHITVARALRCRFSGNFDAPVHGHPRFMGSEKHYLRAQIARITSACRIAPVQTFTTEGAVPDAEEEEGAPAHTPPTAVPAYSVVPPLLPQEMPDEEDTDAIAAVQAWFTGYSKEELMQTKGWSHIAPSVLSCGRVTTALAEEEEEEQEPADGEGENGQGDGASTSEPPPPPPEPEMVAPFLCDISLDAPLSFTGHSRAQLAAWTFRKAYEVEGSQTSVYVAKSLRWPGAATYAVTTTGRPGASYQMMYYGTGLKDMQGAYYAPPLPAPCCHEYVEAPGEFDGQWDCTIDEELRYAPPPPRPEAEEEEDEEEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVV5</accession>
    <name>A0A088RVV5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="8">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MPK12</name>
        <name evidence="10" type="ORF">LPMP_300380</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="8">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="8"/>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701073.1">
        <property type="nucleotide sequence ID" value="XM_010702771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVV5"/>
    <dbReference type="GeneID" id="22577092"/>
    <dbReference type="KEGG" id="lpan:LPMP_300380"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300009100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_300380"/>
    <dbReference type="eggNOG" id="KOG0660">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07834">
        <property type="entry name" value="STKc_MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000972">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="32"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIO00273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="410" mass="46280" checksum="B30DEE2239A055D9" modified="2014-11-26" version="1">MMLTKVEGPNAAGNKVYVFGVNDYRLEVPERYNVQHFVGRGAYGFVCSAVDAVTNEPVAIKKVTHLFDDAVDAKRVLREVKLLAYLNHPNILSLKDLFKSPDPVDTYNELYVVTDLMESDMDAILRSPRIRLAAGHGQYFTLQLLCALQYIHSAHVLHRDLKPGNLLTDSECNLKLGDFGLARGVGHDDTMTQYVFTRWYRPPELLLVCKHCSYSADMWAVGCLAAEMFTGKPLFPGKDYINQINLIVELLGVPDLARDLPPSTSQEAVHYLSSLPPIKGKTLEEYAPELRRRFDEATFFDGFDTELEEAIGAEGATIARPQPRPPEDYYAEFVDFIFGLLCYNPEKRRMAKESIAHAWLSDVRGPQENIGGCEAERVYCWDAEGTAFTIPQLRQLFVEEIEKFTSTRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RW16</accession>
    <name>A0A088RW16_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_301210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701153.1">
        <property type="nucleotide sequence ID" value="XM_010702851.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22577175"/>
    <dbReference type="KEGG" id="lpan:LPMP_301210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300017200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_301210"/>
    <dbReference type="eggNOG" id="ENOG502SINY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267722at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="697"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="752"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1130"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1185"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1246"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1481"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1560"/>
            <end position="1581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="703"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1134"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1194"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1210"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1496"/>
            <end position="1505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1779" mass="188662" checksum="9AC800ABE81A8260" modified="2014-11-26" version="1">MSSDSRRRPSRGEKVIALTHRHGETETTSVGAGTSPSSHPHVFSSSSTAFPEGMLDDEEDEDGGGGGRLVLQFDSSSSPPPSSPLSALRSEVAVDDIAPLSSTNGVKGVKKAVTVEATPSAEILSAHVGATAAPRISDAATAASTNATLNKTATENVEGSVSNAPRRLLLLRPGTDGAPCSLSTPSSMGVQPGVPLSATLDSSRGGRVLNINTVTSAKTDALSAVRIQEAPRTALPPSLVAPTTRATEAKKRAPNVAAAVPPTTFIRTSAASGAPERREWQPFLLSFAYPSGLTSATSTAQQAQPLPSAPTAMTGRRAVVAVHLEFTAVTFGEISSDADTALPVAPCSRGSVASCGWARQCRSRSILSPVVYSHDTARRTSHGYSIIVGDASWQSCCLMCPQVAAVLPEDNDCCCGTTCESAVNSGTGEVRAGPLLDVWVRAVSGRQLSAQQRRRCHRDTFPSSMEECMPNNQPQPQHGSVKLEGAMKDEGVCRVPAASLLSSEPSQPLFTAVFTASWLSQLCCVFTPPSIAVSPCRHPHTGDALWPRRARRSLWPSSRSSSLLWVATQVTQDCVVTHPRCLTDSTSAQRLCSSEVKGEVRYWWLRSDPRQSDVLHWYFCRVLACWASATAAPLATSSSHSCTSRCVANGAVEGSSLLDIIVTKANPPTLSLRGGAVGTTSSVLVAAETLHAAALEAEDAEEAPSTATAAPPVAAAGRRRPSPSALRARVAITAAVLQHLMWGAVARLSTSCTGETSRTGGAEWTEVSNSERRQSTPLPPQEQHVAHLEGMTSRLVCAARVLAVHWVCGSPSLLRSTPASLMDFLAEERLLLSSVLPVGRLLNSMRASSPKGVEACDPVKVPSTTGLDMLLHFESQYASASFAALAWLSQHAADIQLLRGEGFVSLRLHEAESLLLRSALALPESPQLGRLVAHHLHSGETSVFGLRSYTGEPHQRLPLDSGEAMVGLSAPQTPLRGTVNVRIEHAAVVNAFMVHLEWTTMMVAAACDTPAPAFSSGIHGAVELPFLLLVFVVEEDVRGVAHDSEDSSLTSGDDSFTGAGGVGGRAVRLYQVTPFSWRLGAAACAADGFTARTTQLVMHALDLVARRPDVFEGFHMEAIARFGSSKATTAATSARRRKTLKRTRGHWSGPDGADGTAERGACATTVSWKRAARVDTATVRRSGAPLRACKRRRTGVDARDVDRKGSEASGADEDGSSDVEVENDDASSPVLSAWSSRSFRAAAAAASPLDSTPAHRRRPDSGFPKNSGGRSLSVVDTARVVPVVVFREDAAAPLLEVVVSHASQLAAQLASFGSRAAKSTRRSKEEEDEAQEEASRVLCALLDHWIGFSSLHAAAPQYIADLQACQRHGALAPITQLGNMSTHSSALTEPCVLHAYTGLLRSLWREFERLSPLFSHSVAASPLESSPFTRFVSLGVLRAHVLTPACVAAAIEAAIAEYVRQDIECRRRSLFAQRDAAFQWDSEEAEEDEKRESGARRGKPKKHTQQQRVQEELATEAAARATWASVATQMEALVRVFYAEVLGEYPRPSPLLQSDARSRALHGATEKAPLSGSAEGGVVPWDTPNSREIAASERRAAFQSLLHSLLQRVEAEGEGQPPPPQHGDSTMLPLVPTARLQLTGASTDKSTSLRTVSSSWESLQRRTFGAGDVADLNVTVAQLAEACVTQFLCAPRHSCFCSAGATSTNTWCGEKRVDKVAPRSVVGEGAAAQRAAQLLCVSDAFLQSRGEGTSTASVHRHVTTAKLALPLAQLMMSTEAVLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RW46</accession>
    <name>A0A088RW46_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tob55, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_291830</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAM50/omp85 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700788.1">
        <property type="nucleotide sequence ID" value="XM_010702486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RW46"/>
    <dbReference type="GeneID" id="22576946"/>
    <dbReference type="KEGG" id="lpan:LPMP_291830"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_291830"/>
    <dbReference type="eggNOG" id="KOG2602">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1724197at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.50:FF:000013">
        <property type="entry name" value="Putative Tob55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.50">
        <property type="entry name" value="membrane protein fhac: a member of the omp85/tpsb transporter family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815:SF18">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY COMPONENT 50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY SAMM50 PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="domain" description="Bacterial surface antigen (D15)" evidence="6">
        <location>
            <begin position="253"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO00131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="473" mass="52610" checksum="ED06FD20A4FDF027" modified="2014-11-26" version="1">MTEATHQTVNICEDDLKVAMKMPIRAHVRLVGIEKTHPDVVARDLETIKRCLTIQEAVETITEIRSRWISAGIFRSVQYNFEPTADGNQNDICVRLDVVEEKPKKSIGVFTTETSIPEITVALENILGGRYSVKGNYIPPATRVHSISFSFLSNVPLIGQSAEYYIGRKTENKTYHLANSERVEEVKATTTNRKGKLATEFSVGFQRRTLLTKHMKSIPAEDVADFSATDKGYVRHQLTITDVAHHANPFLYNMYPLPIYGTQISFCNEFAGGPVGGDFSFLKSEFQGSKYIPLGPFFSMQLSAKLAGIYPLFGSRIPLNDRLFLSNCHVRGFKSVGPSTLDWGGNISRFAATGGNALWATSLSLNFPFLFFPNNGIASMHLFANAGHVRMTDSLDALKDAYRWLRDCACSIGAGIVITRIPIFGIAPSGRFELNMSIPLGIDKQGNVVCRNGRKSLFDRFRFGLVWSSNFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RW52</accession>
    <name>A0A088RW52_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_301620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701188.1">
        <property type="nucleotide sequence ID" value="XM_010702886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RW52"/>
    <dbReference type="GeneID" id="22577215"/>
    <dbReference type="KEGG" id="lpan:LPMP_301620"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300020500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_301620"/>
    <dbReference type="eggNOG" id="ENOG502S2DW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276226at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="128" mass="14546" checksum="7D0572BEF91424BF" modified="2014-11-26" version="1">MRRCFNRSVLRPTRGATSLATATSSAAIAMPVRQFHSVYGIIGSCLMCGACMLCFGSWANNYCNVKKYGRWRFRNSIDDVIMVSDFRGARYFGAFIGFLFWWFVVGPQKYRWNSNLADIPGNTRIGPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RW61</accession>
    <name>A0A088RW61_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_300080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701044.1">
        <property type="nucleotide sequence ID" value="XM_010702742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RW61"/>
    <dbReference type="GeneID" id="22577062"/>
    <dbReference type="KEGG" id="lpan:LPMP_300080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300005800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_300080"/>
    <dbReference type="eggNOG" id="ENOG502RXYH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276174at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO00244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="179" mass="20068" checksum="0188CADD429F42C8" modified="2014-11-26" version="1">MNPNAQITTRDAAGNMARARYRCHIESSGGMKLEILVRVQMGWISPRVVFSQIPYVIHLGKGIDVSIPFVLHFTMVSLLDEHGDNTGSFLYFSGTPILGFSASFSRITGGKMVLNPTKVVDPYVEVSDFIGHVHYRQMGFVLFKCLGYFLCFLACIPATQRMLQCVLPDPFHRHSEKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RW71</accession>
    <name>A0A088RW71_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mitochondrial solute carrier, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_300240</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701059.1">
        <property type="nucleotide sequence ID" value="XM_010702757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RW71"/>
    <dbReference type="GeneID" id="22577078"/>
    <dbReference type="KEGG" id="lpan:LPMP_300240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300007700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_300240"/>
    <dbReference type="eggNOG" id="ENOG502RC6T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276754at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="133"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO00259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="355" mass="40582" checksum="E2931A3AA281E265" modified="2014-11-26" version="1">MSFDSSRGYRSTFGYRTATPYQEPIAHRQGYTETQLTTRQHGAVIVGCSTACAFVTVPIAKLDRFYFLSDVPGESGRIYMSDKRAQLFRVVFHTRWWQGRSVVWLAADYGFLLATFAMLRHWLETATVTAQWNSRRRGFVAGAVTGVLYATMRHPYDVLRATAEALAGPHQFRGAADVLVTALRERPRVLLGVYRGFSVAVLSRSLQFALQFGLYNWMRYDGVYRHSMVLFLYCHLATFLGVMAQYPVHSLRQELRVLNAATRGRPKSYRSLFLDLRRRHGITKLYDGFFRSKPILNAVPMALLMTAYDMCTRRFTEYLHPEATAVPTHTQSFTSVAAPPYVTHPPPYEFVRKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWZ2</accession>
    <name>A0A088RWZ2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_303170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701339.1">
        <property type="nucleotide sequence ID" value="XM_010703037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWZ2"/>
    <dbReference type="GeneID" id="22577370"/>
    <dbReference type="KEGG" id="lpan:LPMP_303170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300036600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_303170"/>
    <dbReference type="eggNOG" id="ENOG502QPHT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="77911at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44927">
        <property type="entry name" value="FK506-BINDING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44927:SF1">
        <property type="entry name" value="FK506-BINDING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="859"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="295"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="358"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="467"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="869"/>
            <end position="881"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="881" mass="96766" checksum="B97B09FFE187B763" modified="2014-11-26" version="1">MSAVDFTCVVNAVLYSFSESAGTYDEYGPVSCALIGSKANDITFKLACYRDNKYICTATVLPSNDAGAHIARDGAYITFRDEKSHYWSLQFAAEDAAIEFCAQVVVAMFGSAGEPTDSILSCDVVKGKENRQIFVGNLVKAFYRAWVVQSNDSSDGLPRLGSLLEKESEDVVKFTAPASHQCVTSTMRGFEGLTVGMKEGGQRLIVVPVRAKRGRGPNVNMCFYVEIVRRKDQQSSLRYQSHRGANEKSQLLLTEGDGGIATGSLAQPLAAYSGFVDGHSATVASGFSKEQFLLVDRLRDQVFTLTEQLRDTRRELDSLCADLKRQERHSGTRSLTSAQIEYSIEHLLAESEAKKNALEDKRAVIGETESRNRELESRLAKFLQTTKILGEEAKAALDDSAGERIELDRQLADTQASIVRLDGEVGDLSRHLHALNNVLRANDVRLKEERVRLSVSVNDHEVNEEKLRTLQENYSEEVARRKLLESKLVSLQEELRRFQDDVQLKESLTQQIRAKTESDSVHYAQLIQQEREQAAIELRQLKQDLIEELASRDRQYGEAKERVAAEAYEQGMAQGVEEGLADAANEGDAIAHDMAVNAQRCKAESAALQVRAQANWAASEADERNFTAQIESLQASLTGALHDINILSTQLEAVQEEHTVKVGGVYQRLSRLIHFCGAAPISQPCLEAMMRAAESGAEFDPFSFQKLEAAKEAQLARDERVAVAAWVRASVYNERTRMPPLRPPFPYATSSKGPLLSPETMGTKVLLSPAVHHRLPVSTEMATSITTATPVLMESTTPVAPGVVEADIPEPSAALPPPLVVPASPPAVAVSQHSEPQDTAAIQKAPQRQRVQFPSTKIRYLSDGGTAGVMTTPTHQQPPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RX04</accession>
    <name>A0A088RX04_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_310640</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701453.1">
        <property type="nucleotide sequence ID" value="XM_010703151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RX04"/>
    <dbReference type="GeneID" id="22577490"/>
    <dbReference type="KEGG" id="lpan:LPMP_310640"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310011600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_310640"/>
    <dbReference type="eggNOG" id="KOG1099">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20105at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF19">
        <property type="entry name" value="METHYLTRANSFERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="5">
        <location>
            <begin position="2"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="172"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO00653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="331" mass="36716" checksum="80EB67E0BE97FCE3" modified="2014-11-26" version="1">MYRCQSAWKLLELNDRYRIFHQFHPSTVVDLAAAPGGFAQAALELMHIQETARPSSLPPMVIAVDQRPIDPMPGLLAVRGNILQHQRILQAVQGVFSHTRAPTASPSRLSSSTQTVPLARSVDMVLHDGVSVVKGQRAFSVTYAQNQMALSALLLAGKLFRRFGPMPDLPAEAEKHPSNKRDERISHRTSAPRSSPAVLPVCFVSKVLHCHHFEQVLTATRALFRHVKTSKLLASRSESLERYVVATDFQLAAWQRLTTAHLPTWPQNLQQHREQSRSTASASLFSMPPAPEDCGDVHHIVWNCLGCGRTCTGCQPCMQCGPYQPVEDARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXA2</accession>
    <name>A0A088RXA2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MRP protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_282620</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700601.1">
        <property type="nucleotide sequence ID" value="XM_010702299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXA2"/>
    <dbReference type="GeneID" id="22576707"/>
    <dbReference type="KEGG" id="lpan:LPMP_282620"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280032700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_282620"/>
    <dbReference type="eggNOG" id="KOG3022">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001119">
        <property type="entry name" value="Iron-sulfur cluster carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961:SF2">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="263"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN99894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="292" mass="31291" checksum="D6F81E7D88913E3F" modified="2014-11-26" version="1">MHFSRVSVPGIKRVITICSAKGGVGKSTTSVNVALSLKNMGYRVGLVDADITGPSIPTMMGVEGSQVETYRVAGSDRFGPPMNFGVKVMSMGLIVPYDEAIAVRGPMVNKYIRALLFQTDWDELDYLLIDMPPGTNDVHLTITQEVTLSGAVIVSTPQKVALIDVRRGIDLFAAVNAPVLGLVENMSYFQCDGCDTRHYLFGHGGVAHAAAELGVPFLGEIPFVSRIMQDTDEGIPPALRGDATLEAAKPYYELAERIHATLDGSERDTAGGGKGRVDRHAAPAPEPTITFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXK5</accession>
    <name>A0A088RXK5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Glycylpeptide N-tetradecanoyltransferase</fullName>
            <ecNumber evidence="2 5">2.3.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">NMT</name>
        <name evidence="10" type="ORF">LPMP_320090</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N-terminal glycyl-[protein] + tetradecanoyl-CoA = N-tetradecanoylglycyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15521"/>
            <dbReference type="Rhea" id="RHEA-COMP:12666"/>
            <dbReference type="Rhea" id="RHEA-COMP:12667"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:64723"/>
            <dbReference type="ChEBI" id="CHEBI:133050"/>
            <dbReference type="EC" id="2.3.1.97"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the NMT family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.97" evidence="2 5"/>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO00898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701698.1">
        <property type="nucleotide sequence ID" value="XM_010703396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXK5"/>
    <dbReference type="GeneID" id="22577750"/>
    <dbReference type="KEGG" id="lpan:LPMP_320090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320005800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_320090"/>
    <dbReference type="eggNOG" id="KOG2779">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="60315at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004379">
        <property type="term" value="F:glycylpeptide N-tetradecanoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.170:FF:000004">
        <property type="entry name" value="Glycylpeptide N-tetradecanoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000903">
        <property type="entry name" value="NMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022677">
        <property type="entry name" value="NMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022678">
        <property type="entry name" value="NMT_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022676">
        <property type="entry name" value="NMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377:SF5">
        <property type="entry name" value="GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377">
        <property type="entry name" value="N-MYRISTOYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01233">
        <property type="entry name" value="NMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02799">
        <property type="entry name" value="NMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015892">
        <property type="entry name" value="N-myristl_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00975">
        <property type="entry name" value="NMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00976">
        <property type="entry name" value="NMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase N-terminal" evidence="8">
        <location>
            <begin position="36"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase C-terminal" evidence="9">
        <location>
            <begin position="230"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIO00898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="421" mass="48601" checksum="7A68F04C24182074" modified="2014-11-26" version="1">MPRTPPHSDGKHAFWSTQPVPQTEDEAETDVFAGPMDEPKTAADVPEEPYPIASTFEWWTPNMEVSDDIHVIYKLLRDNYVEDDDSMFRFNYSEEFLQWALCPPNYIPDWHVAVRRKADKKLLAFIAGVPVTLRMGTPKSLKLKAEEKGQEEAAAKYDAPRHICEINFLCVHKQLREKRLAPILIKEVTRRVNRTDVWQAVYTAGVLLPTPYASGQYFHRSLNPEKLVEIRFSGIPVQYQKFQNPMAMLKRNYHLPSAPRNSGLREMKPSDVPQVRRILMNYLDKFDVSPVFSDAEIGHYLLPRDGVVFTYVVENEKKVTDFFSFYRIPSTVIGNSTYNMLNAAYVHYYAATSMPLHQLILDLLIVAHSRGFDVCNMVEILDNRSLIEPLKFGAGDGYLRYYFYNWSYPKIKPSQVALVML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXQ0</accession>
    <name>A0A088RXQ0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_291040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700712.1">
        <property type="nucleotide sequence ID" value="XM_010702410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXQ0"/>
    <dbReference type="GeneID" id="22576868"/>
    <dbReference type="KEGG" id="lpan:LPMP_291040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290014500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_291040"/>
    <dbReference type="eggNOG" id="ENOG502RZZC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273698at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31535">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31535:SF3">
        <property type="entry name" value="REGULATORY PROTEIN ZESTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="470"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="512"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="995" mass="104349" checksum="A4573B48C733041D" modified="2014-11-26" version="1">MEEASASPSAASTALTQVNIEFSNNDALVPAPKALVGTTDEGGRAPCNRNSRRIQFLDDGKLFEGHFTVQSRNLKTIIQYLANRQSEQDVIIQDLQKQVHLLRTRHVKARQRAGGGGGASLRTATAFGELPAGQGVVERVKSIEQFLQLWGVRLGEVAALVEEHGDPVITPDAYTSYLVDLPAFRFARRETRAFVISASQQAPMSTAATAACDTAARRRNTSNQPKRETASAGSFSDIEKKCDDDATETALEKATAALEKAEMLLEELRSIPARLPPPSTTKARRAESSVSVPDKGSSGGGGSAIDHEARADIEELADYVMRRFQELETQSIMTAATVARAAAAPRAEKGGGNSGGGGGAAAAAKAASARPKQAPAKKPVSNTISPVSAPAPSPPPGVVPGEVIDTVAREDAAASLDLLEELEVTMERRFKEVNGVLANIAVRTASMAKRISGGAPSEAETEKQQQRTGSPSSSKSVSSKSRSPSSGKHADKNTELKPAVEDAETEVEDARMSASASPMPSSTSKVSRPSKGKAKQIVSDPAEPLIPRAGVDQVAREETAILSDRVSDLEEELLDRWKAMEERLRIIGRAAMKQSAASAAAGPGGTTATAVSRAPVVDRKAREDAALSLMRLQQLEKDLVQLKRQWGSAGAAARCALGSADPPAGPNETALTPAVVSMEPSVLLRDTYGSKVADLEKEVEQRMADVNEAIAQLSGGAIGITPGLGSAGLAARVTDGTSRVDVLFNLHTLARTAPSAPSAESLAILPDQTQAHRSAVTSPSATSAQSHLTLRAVDADALPGVATEGCLPEVNPSRRAEMYQSLLALGYGKSSDAGLFTAYPMNDTPLGAKRTTISRLRPPDEPTFGSNLVQRAVIDLPADTTIAAAEEAVNAAERRISVASGTAAAAPLAAGAQREAVAAARSSHLEGRSFSVSPLPGAPNGSIARVRMSEVRGVSFTTPKSPRERRRETLGHTEPCLVVNCAWCDAEKAPESVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYW9</accession>
    <name>A0A088RYW9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Delta(14)-sterol reductase ERG24</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">C-14 sterol reductase ERG24</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Sterol C14-reductase ERG24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">LPMP_322450</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17813"/>
            <dbReference type="ChEBI" id="CHEBI:18364"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.70"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:18563"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="15">Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 2/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701931.1">
        <property type="nucleotide sequence ID" value="XM_010703629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYW9"/>
    <dbReference type="GeneID" id="22577986"/>
    <dbReference type="KEGG" id="lpan:LPMP_322450"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320030600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_322450"/>
    <dbReference type="eggNOG" id="KOG1435">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5326588at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050613">
        <property type="term" value="F:Delta14-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016129">
        <property type="term" value="P:phytosteroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902652">
        <property type="term" value="P:secondary alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000009">
        <property type="entry name" value="C-14 sterol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF52">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE TM7SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01017">
        <property type="entry name" value="STEROL_REDUCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="8 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="9" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="12" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="376"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00060638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00074394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00077841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00083315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="AIO01131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="437" mass="48845" checksum="5874E39394157856" modified="2014-11-26" version="1">MAKGSGAASKSVGNLLQPRTTTYEWGGPVGGFFMVLFLPTLVMALNSLCAGEQCGITQAMRLPALMTELVRGAWPMVPKAIGIELVWLAAHAVFSILPIGRLVHGGELRNGERLAYRMNAIHAFIISHVVLLGLHYTSIVSMAVVADLFHPLMIGAIFISFAMSVVLYAASFRRRNVLTALGGNSGNALYDFWIGRELNPRTGPLDWKLMCELRPGLIGWSIMNWAFVCKSVELGTVTPSIVLTALFESFYVLDGLLLEAGNLTMMDIVTDGFGFMLCFGDLAWLPFTYTLQTKYLVHHPAHLSPLHLCLCASLSVAGYVIFRGANTEKDRFRSNPKDPCVQHLHVMKTSKGKSLIISGYWGMCRHPNYVGDWLMALGWAAFSGTAELLPYFHPIYFGFLLMHRQLRDEQQMREKYGREDWNAFCRIVKYRLIPYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZE8</accession>
    <name>A0A088RZE8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thiol-dependent reductase 1</fullName>
            <ecNumber evidence="3">1.8.5.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TDR1</name>
        <name evidence="3" type="ORF">LPMP_330280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.8.5.1" evidence="3"/>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702121.1">
        <property type="nucleotide sequence ID" value="XM_010703819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZE8"/>
    <dbReference type="GeneID" id="22578181"/>
    <dbReference type="KEGG" id="lpan:LPMP_330280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000012700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_330280"/>
    <dbReference type="eggNOG" id="KOG0406">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045174">
        <property type="term" value="F:glutathione dehydrogenase (ascorbate) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041695">
        <property type="entry name" value="GST_C_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16865">
        <property type="entry name" value="GST_C_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="92"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="230"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="316"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="450" mass="50248" checksum="C85800B2040AE120" modified="2014-11-26" version="1">MTSRALKLYVAATCPFCHRVEIVAREKKVSYDRVVVGLREEMPQWYKEINPRETVPTLEVGCAERRFVFESMLIAQYLDNSCAPAGALMGASAVQRHRIEYFLTQVGDFIGAAHELLGDPLSAEKRSALSDSAAYMDELLAANQTTGPYYCDGEFTMADVALVPFLVRLKFVLMYYAGYDVFCKAPRMKALWAAAVQRASVLETLPTAEQCVENYRHLVPESAPMMGANGGYVLYSNHLCPFADRVRLACELRKFTVHAVEVPLHPQPEWYQHFNSLGTVPALFTPSGEAVHESQLILYYIDRLATGDTVLVPRGDAEKEYEVGFFLDNAGYFVTGLLSWFFGGSEDAKAEFEWAAGELEQQLAKHPFGEGPFFGGKTMNAGDVAILPFLVRVKSLTPELTNGYDFFAKFPLLNELAEAGMVTPEAKAVFCTPEEYKKHILQLQQKARDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S004</accession>
    <name>A0A088S004_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transcription elongation factor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_332930</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702384.1">
        <property type="nucleotide sequence ID" value="XM_010704082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S004"/>
    <dbReference type="GeneID" id="22578446"/>
    <dbReference type="KEGG" id="lpan:LPMP_332930"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330037300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_332930"/>
    <dbReference type="eggNOG" id="KOG1105">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="44867at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05162">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13749">
        <property type="entry name" value="Zn-ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000052">
        <property type="entry name" value="Transcription elongation factor-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF12">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PWWP" evidence="6">
        <location>
            <begin position="6"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS N-terminal" evidence="8">
        <location>
            <begin position="164"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS central" evidence="9">
        <location>
            <begin position="324"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS-type" evidence="7">
        <location>
            <begin position="432"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIO01584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="474" mass="51410" checksum="3AF219FCC005B7DF" modified="2014-11-26" version="1">METYAPGDRVWVYIEGDGWWPARVLSDEEMGTRTPGLDLAVQFYAGVEQPATLYELNSHADAANICFFETSSEKAVTGNPELEASIRHASADAEANPLKSASAMVVGTRVAAGGSGAAGNLGAVAVNRAAAKRVRDTGDGSMGTYDGGAAASRPVSGYHHLRSEELHELSRKISSAVAAQDVATVRAVLCRLDSVDVYLTELEDTKIGVAVGSVLSQLELKPLWPLARAMVSFWARHLPPETLAAIRSVQQRQLSFPPIGASAAASATQHSSPLGKQQRVSFALPGESAFMNSVSPSVTTTAAGAGAAVSVDSGVVASPQGKTFYDNVYQLLDSPLSAMRYDDAVIEKVTRKLAAEITDRDERQLLLLRLREEELSFIRDNLLSGEWTPKKYLDQPNEVFTTKSEKARQEQRIQEKIKAIEAADNARLNITALFKCGRCGKRHCTFYEQQTRSADEPTTKYITCLDCKHTWIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0H0</accession>
    <name>A0A088S0H0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translin-associated factor X-interacting protein 1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_342770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702703.1">
        <property type="nucleotide sequence ID" value="XM_010704401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0H0"/>
    <dbReference type="GeneID" id="22578782"/>
    <dbReference type="KEGG" id="lpan:LPMP_342770"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340033900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_342770"/>
    <dbReference type="eggNOG" id="ENOG502RVT0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272480at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839205" description="Translin-associated factor X-interacting protein 1 N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="229"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="585"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="307"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="229"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="590"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="616"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO01903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1186" mass="131765" checksum="265D95C8085C1C0B" modified="2014-11-26" version="1">MPCVLLLLLLPPLIPVLSHRCFSRTLLPVHTFRHPANTAHSSSVVNMSQQRSTRALPTLRHTTPGIHSTGTTRTARVYKKNAFSLDGCLRPLPTRVAAPLASPLGPAAGGDSLVNLGEAPSPAEALMAITCAPPAEKPVSSSSSLYPTVESWRSQLLRCETELRELLACGVHDPPSLNRTLKTMELFDRVSCIIQAQPNTSFIGDLLRLFRVEFCRSIFVAQSNDDAVGDNSDTTGSITGTQPHRGEGTDGDNLRRLKDGSSLRKDSGLTQTYFDEVESLRRAKVFLTAALGKSTSGESLVLLQRCVEEKDEQIAWYEAELERVRRQFDQVTDECRRLRQKLEADAQEAATIHRQLQRDIQNLHVENKDVQLRLFRLRKQVSSNVSNHLREGYRQLKLSKIAQTQSLFDEGDERVVLLVLLGQVESRVNEILDAYDNDFVLTTEASRRELRKAMTDDVVVLLEDMHFCDAAYRRLVAAHRTGGNSGKTMVADDDAVQAGAHGIPLELVHSGNDEEAPDETDGFVAILFDQRVYEYFQARHAMQARLQQYQAMNDITPLQTKATRTAPGSAMGSIELDPPMLHQESQTPMMHDRHGAGWREQVHSNSEQSGALARPSTENQGTLTSSHKPGSLGSQPFRPAAGLPTPSVTPKGRLLSKPPSFAQHARNSRAVVTILPDPPAAQGAPSLKRAGRGQRAEWVANILGPSATSVAFTIPRPNSEQAGVVVMRQKVSEVLPAETVMQRVLRHPMHDLSSERFLSTVEVFTGEDPVQQRLLCRMNYVDPSLSIQVPDATNFVKIKYAHAEKARVVAAASAGVRESVVPQSSSQSSNVGGGDNTGIYRGNPNLRLFKELGSKSLVENNAGLQYRAGAVSSTTASTVAFQRLNPLSPDRAPEWLLYQQLFGTYRSLTPRMIEVTTIDHLMACASERFFIRMEYRYDKCLERAAQQCANLQLRQDMAGRFFKDMYVLSDFQEALVDELEARYGYPELVGKTLYEILCYLDAVVEKDSVLAAYLDVIRGFVSPAQVHFVSYMLYHLSYCWPSADPTASVSADDVRTVFDYIYRNASALLVIDPEDVFKDYNIASRSAPLTFVSMRQFLASAMAHIEEPLLLLLHGRFHAHTQRRATDEITWDTYETVVTRCGRMKEERRSLVRFLASGLGVNRPTFPSLQQVTFLAASAWCSNLWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0H4</accession>
    <name>A0A088S0H4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_342820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702708.1">
        <property type="nucleotide sequence ID" value="XM_010704406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0H4"/>
    <dbReference type="GeneID" id="22578787"/>
    <dbReference type="KEGG" id="lpan:LPMP_342820"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340034400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_342820"/>
    <dbReference type="eggNOG" id="ENOG502RID9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271814at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="359"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="380" mass="40911" checksum="17831A1A7FF01120" modified="2014-11-26" version="1">MLKTSKTLAALLPSLSFGVNKTDFFTNLWRKPQTRDERVKEYVPEVLEESLVEQHAVLEESTSRDIIVELGNKILQEMDNKSPTPNIAPHLNRLLLEYGVKDVIAQRPLSYLLYPNSSALSAGEQAHELVSSFPDNFRAMIEEVERNGCSAKIPAPLLSASEAHALKAAPTVAVAGHDPTSSVDLGSGAATSGGPESPAPSDSTPGDDKASSPSRRRADSVIMASKDEYEPMDITMFVKVAAGLAMANLHCGDMRNAVRCVDAGIAYAKEASRLGGLLGLKAGLLVHQKKFVEAAHCAQLAVETSGNVQGYLHGAYALRKLSRLEKAVALLERGREDHPMNTQFETQIEAIQKERRLTLPASSSLSSTNTDAAQEALPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0H9</accession>
    <name>A0A088S0H9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_341230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702549.1">
        <property type="nucleotide sequence ID" value="XM_010704247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0H9"/>
    <dbReference type="GeneID" id="22578628"/>
    <dbReference type="KEGG" id="lpan:LPMP_341230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340018200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_341230"/>
    <dbReference type="eggNOG" id="ENOG502SHSM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273129at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="426" mass="46179" checksum="088796D13D0AA30B" modified="2014-11-26" version="1">MEGSIYTSTQICMACGFPRGSSVSCPVTQRHHGTDELITSGRPRTNHHRVVPKNIFKRMQVKLPVLVIHTSGKLIRVRNKHNTQTVREVHPLAPGAEGATADRTGGHSCEVDPSRAGGVGDPVSPKSRIADRKSGDSAQQHSGIDMGETGDTVNEDASQEGGEVQYYCYTDENGDTYWCTQELPDSMQQSQSDASAEVGDTSAQGCMTYYEALAGQYEAGGSVPEGSCICEYVDKDGQTVYYLYTPEVNNTQDNAAATPPQAPDTNDDSTASALAIAVAESKVVSAKESDPTTSSTRKPPHAFLSAITKAFKPHRSSRTRDRNNDLAAQCGGDVDSDFFTADWNAEPPAPLGTVASESPITSGPSEVSTYDNDVEEFMELLDDGEKKKFLKERKRLIKELAASEKKERESIMKQRSDGVEALRRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0Q6</accession>
    <name>A0A088S0Q6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_341490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702576.1">
        <property type="nucleotide sequence ID" value="XM_010704274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0Q6"/>
    <dbReference type="GeneID" id="22578654"/>
    <dbReference type="KEGG" id="lpan:LPMP_341490"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340020900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_341490"/>
    <dbReference type="eggNOG" id="ENOG502SJM0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="261804at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO01776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="355" mass="38534" checksum="6066F2B6F60E8736" modified="2014-11-26" version="1">MRPRILRDSGVLPTLVARSEDVFEESNSGCTLICTPTSNVAVVGERYDTTAGNAAAALPMKWDSNEALWQLKIALGVTPVLQGRSVSHLTHPAPRTHNSAELSVEPNARDEEVVTVTPTASTSTKLPPSALGASGKGNGLDSFIPPVYRFSSVSSAFSSPLLEAYLQSALTRIQDECDALMQYLEVGAAPLGAEGLQTIADVPDDELQAAQRMYFLAESSTLTQLQRRADAAILEKEYVFQIRDLLAAELQRRHVPLEAAQDDFHPFFEQVDRTKMALDDYYHVQSAMHTMTPMMEAAVAVAECLRDVDATTSAQGMQHLDGMETAMDSLLAQVQADAVVLQKNLAALQCRLEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0U9</accession>
    <name>A0A088S0U9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_322490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701935.1">
        <property type="nucleotide sequence ID" value="XM_010703633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0U9"/>
    <dbReference type="GeneID" id="22577990"/>
    <dbReference type="KEGG" id="lpan:LPMP_322490"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320031000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_322490"/>
    <dbReference type="eggNOG" id="ENOG502S3AN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1929236at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="829" mass="89472" checksum="3370A9BBEE7FBFB4" modified="2014-11-26" version="1">MSSELGLARYFNGLAAGDEMAELIRGLHSSIWRCYQDCLQRPVAVQVPASSVSANGAGGGVGAFANESAEHSSRSDDVPLRGSSLGNAGTRFTSPANQSDGAEAVLPIAAPAKPTPIPRGRLKAALRRQYWAATKAAMLFAVESPSVAEEATALHCSNIARSLLYNYYYPSDNRDIASSSPHARATLGIAPVISTLQQGEVRWVLSDTRIVELARKELKANRVDGAVCGWQRALALLRQVDPTPLTSAVELELYRRTDGHHWAEALGCLWRIKPAHWTEMDVAAAVRCLYSAGRRRHQESSVSMSPDGAEGATTEGGESTSPASNTVFVARLTAQALRIHHAVETAGVLRWSTSSTFNDTLGLIAFGTAGWQDACVLLDKLLASAAAGARSRDPDLKQNAARGVVGTGRGEKAVRSEQHRTGGEAAADDESLLAPTSDESKFMSQGEDTSVTAYSQQRAPSPVSLYHFARANAVTVHQTCRAFRSRWDVGLRYVQLLQEAFADTLNLSSDTAATEDVLRLCIAGQQWEAALRLVTAHKAAMADGAEGERLPAVVQDGSSIAAALKGHAAAVAAAPKRATLSQHRRHYRPDVFVQLVSLLGSVQASRWAAYDLIHRYAAPGAALSTAAVNLDRRNSTTVGLRLSKHYNTNTLSRAYNCLVQNADTLDAAQQVLEQVRCFQSPAREGSSVVTQDKKSCPGGNADRQLRDLDAELVGLETESVAHITYLSAVAGDWCRALHHANALLHEPRYRSTFFPTARLHDAVQYALEQASSPGPSWQVSLQLFTEMMERNVPISEVSFQSAVKRCFSGRVPDQAQKLFYFVLRKGVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0X8</accession>
    <name>A0A088S0X8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_342450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702671.1">
        <property type="nucleotide sequence ID" value="XM_010704369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0X8"/>
    <dbReference type="GeneID" id="22578750"/>
    <dbReference type="KEGG" id="lpan:LPMP_342450"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340030500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_342450"/>
    <dbReference type="eggNOG" id="ENOG502SKBY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273907at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="31874" checksum="39CBCDAE9FF87D2A" modified="2014-11-26" version="1">MKLQPRERRERQDYLVEHAAALQLGKLYLGWGRGKPRLKSKRATPTVESKQKVAKTSPRAPAKETKKVRRNPASPVLPVAKRPPGRPRKTSPPAARVESTPTKSKSCGRPPTTPAKAPRKPTARESVRSGKNLNPAVKPLSSKAVAAVGNGDKLPCKPPPRAPRKTAAVLTTKTVVQHRRRANRNAPPVIPNPVPTPALSLGEAEEAVDGSNVSVLVRTMNGTSFGLACTFESTLYDLKRRILEIIIPRAASASPAPAVRLPMLVMNGRALGPETATLAALRFPARPTVYCFPEPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S156</accession>
    <name>A0A088S156_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_345040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702923.1">
        <property type="nucleotide sequence ID" value="XM_010704621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S156"/>
    <dbReference type="GeneID" id="22579009"/>
    <dbReference type="KEGG" id="lpan:LPMP_345040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000023500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_345040"/>
    <dbReference type="eggNOG" id="ENOG502S58Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="2">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="2">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO02123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="257" mass="28659" checksum="27BAEA876A0A64A1" modified="2014-11-26" version="1">MSQQQWTPDQRRQQIAEFLRNKGLICRDFLLTGRCSRTPMCPYMHVANGETRPVPWSVCTFFTQGKCLRDGCSFFHGAQSQLQELHASGAPVYRPQDYMKVAVPPPEYLNPDGSIATHLSIAEVSMTPALHVVHGPTVSQENVVNPFHPFLLMQSNSQAIAPTVFASQIRTPNSTPQHFAFYTNTPITSSMPTNSTGTVLQPALHVVQPTAYYQAISTPLSQTQRHYAPALQLNTSQQQQSTQQPLGSHVYFHIQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S157</accession>
    <name>A0A088S157_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_323940</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SHQ1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702075.1">
        <property type="nucleotide sequence ID" value="XM_010703773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S157"/>
    <dbReference type="GeneID" id="22578135"/>
    <dbReference type="KEGG" id="lpan:LPMP_323940"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320046700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_323940"/>
    <dbReference type="eggNOG" id="KOG3247">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="73639at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000493">
        <property type="term" value="P:box H/ACA snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000080">
        <property type="entry name" value="Protein SHQ1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039742">
        <property type="entry name" value="Shq1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048696">
        <property type="entry name" value="SHQ1-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007009">
        <property type="entry name" value="Shq1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12967">
        <property type="entry name" value="PROTEIN SHQ1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12967:SF0">
        <property type="entry name" value="PROTEIN SHQ1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04925">
        <property type="entry name" value="SHQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21413">
        <property type="entry name" value="SHQ1-like_CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHQ1-like CS" evidence="4">
        <location>
            <begin position="3"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Shq1 C-terminal" evidence="3">
        <location>
            <begin position="361"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO01275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="577" mass="63620" checksum="265A035CDD7C43F1" modified="2014-11-26" version="1">MLTPVFDCSQEGGFVVIRLFLSAICKVMNAVFDIHETQFTFYCSPYYLRLRFDQCLGEGRGERATYDLETCVLTVYLPKADAAEVFTKLDNPAYLIATEKQRASLIQVLGGANSSDAATGAGDELEETEYVQSSPDATAAVGAADRSESLAPEEQCSYGFANAFSGLFQKLDTDVVREVVSLRCNPECTTREERRRLRLAAEMSDFDVDALLFAVEDAEGEVAQVLRYVPTHMRDFQNALQDSTTGPGREPVLPQVVVASIPDADGCASCRCDADPLEEEESTLLGGDDARPVTVWSGNVADFKKPLIEELHPVVNVERESASSATVAGAVASAVSSQTATKTSVPPEPRTRLAIPRVRPSLKFTRDETEILMRLKLPRLLFPPSQAEVEALTADLLFSEAYDDLVTEGSGCSESLWNLTQLSPALSYLDPADTLYDACVAFARRALVYPLHRHCALLQRVWAVVGTRLLLGRNYTLRALLRVRIILSHAEHKHLLSTIYLDPLIAYWMHVPTADDCLMRMGLEIHQHVSRIKSTTVSKSGAPALHSMLVDADRVTLYPLTLAYFGLPLSEEREDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1B4</accession>
    <name>A0A088S1B4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_330570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702150.1">
        <property type="nucleotide sequence ID" value="XM_010703848.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22578210"/>
    <dbReference type="KEGG" id="lpan:LPMP_330570"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330010300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_330570"/>
    <dbReference type="eggNOG" id="ENOG502QZ2A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271999at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1320"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1884"/>
            <end position="1910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1889"/>
            <end position="1900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2026" mass="218161" checksum="36CE36C77FF4978F" modified="2014-11-26" version="1">MEDDVAVCLGGFTKELVYQQLLHCSEEGSLLRLLTVELVANDGHTLVLAAPQPSTMGSDAASASPLLMDVSGDDRESAVQAAVTGDAAFAHPADLLLLRCQPRRPPANVTGRSGAASDSGAASGAALATHQEFITYNTSLFTPSDVDLWREAVEGNITVVVRWLAALVQQPPGLAQLAFLEAAAASSSPNAGGSAGHEGWRRTLQLPMLLCLKPDVMRCADAKTLDRLRRTVSFALRTLLAVFLHVESAMRLPRLCQRLVYLFLSSPLYVDGASQVAMQLVATDSAASTRQSMVHTLHSCLLLGLQYASDSAAVSMDSSLATAEVRRSARQACNGFELVLARLSRVWLQQSHSGRSKETAMDVSGPEEAIFEVLEAVAATGVLKEVLRWLQLEEDVRRSHDHLGANCSGSSDDMTDTLAELLVPPTLHHIQERRHLQDCAVAEQLTALRRTYNPYLSHEVQQFIRSTALAAYAELYASAARAVRHVTKLPGGAAELCRGRVDGVIAVRVSGLEAVGPRPGGLSEYSLAEVQHYAAFGLPVDLCVRGSRERRHQDEMKALVSALQLAQVSDTDASLFAYAMVQLTGQWVIFPLVLTHAKADSPSKEAGSSVSTTSSRVTAHVLRDADMLADFILTSAAAAEDGQTQAWIVLGAEGAGNQRRSSRRRRAALLSATAAPPPERLLPTGTPAMTYLDCLRRLHALSLSIRQAEAGVSSKGRTNNANGRGGSRRVGRSFGADAVSGLWTEHFTDGAVPMQRYVSSLTAPVAALLSGTGSGVDAVSSLRSSGSSGRLPGDGTFTSLQTLLALVNEAADFSSAQVEALHSLSAVTGLSRNGTGAVAQGNSGVPVSVRMVDGCTGSGKTAVLYASALVRGKLHAAARQEQQRNVQGSLKHAMASVKEAVAALRCASVAELFSTSADVRAGRSLLDEVSLVAAEARRLYQQLNEGFLYCSTPLLLRPAVATSTVPASVAQFLFEASKARPVEGQKRGRPNGSRNAPAAWQLSEITSLAALVKESHARSLNAPLTTQLNAELRRLQMTGMWSGVCRTAVSVAVPLLSLTLSARDATDVVACASVSSTPAQSWAEFIVSDFWPESDVAATLDLAAAAAAAHDGASSATWESLTAIPEERYAPVTMPPTTHLSSLSKEQLEGWHSVYLEKQSELAQHTHAAVHESVRSLFQLFLDLVWGVAATSQSTRHTVLTSTPMELTQGLLLPYLWCWQPSHMCVDDIDAVQDGFFAMLTPVSSFVYSLTSEVPAFQERRRSHERIVLALLRSLHTELRRTGDLTTTVLHDSLRCRRAEVQALLRYTIEDARALSKVTEELANSEGDGAQQDGGSGEAAEPLQGSTDSTVPPPPFTGLASYSAVEVWSHGVSMDNCVAADAAAAVFLMEYLSSYFPARGDSASATTKSPAQISFGVYTSNAAAAEAISAALSRSALAPSSHFRQSVRVWRESLEGAGNEAVSRDSFVTATPPVMATAMSSTSLDEVECEVEIGVVCLSGLLEVVIGALHKSRDGSSDTIVDGESHRPEARHQQWQQLWAESSDGSASLFVTRLQWWLWRLLRRVRHGVFLIGSRELFACIPLFTKAESLVQRQRRLLAPKNHRGYWLPSEVGASVLAMVCPDHFKCRRIAVVREHDDAEAAAEPSPEGDEEDVDAEDEFVTVEVHGPTECLSLCLQTYDACPSISHACLRPCHTQQRIGAAHLEENVSLTTDDAPHASCPYPCSAVLPCGHACHRVCSASCEPCTYAGLTELTCGQRVVSGTDSNQVVQYAFFHHFQERRCGEPTGYCCTPVSVLCKRCGTRSMVACHCVTAQLSRRQRVTEEEETRQNTVANDATYVLKETSCAGCVALYNKVAKKFGHELLEMPPVDHAQDSHHITAAGHLRGSADADDGDEEEDGEAMGTALPRHLLSTEAQTELRREFTIASKKSELLVRKEALEISSGRVTEKTDYEVYRAQYAALRATQKSQEKAWRDEYHTMLDGWAVKLRHALEVQTALSTELDTLMPRLVAEATEEAHLQRLQFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1G0</accession>
    <name>A0A088S1G0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_344700</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702889.1">
        <property type="nucleotide sequence ID" value="XM_010704587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1G0"/>
    <dbReference type="SMR" id="A0A088S1G0"/>
    <dbReference type="GeneID" id="22578975"/>
    <dbReference type="KEGG" id="lpan:LPMP_344700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340054800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_344700"/>
    <dbReference type="eggNOG" id="KOG0182">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5835702at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03754">
        <property type="entry name" value="proteasome_alpha_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000055">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034642">
        <property type="entry name" value="Proteasome_subunit_alpha6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 6 7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="8">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIO02089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="250" mass="27254" checksum="C43F9A7D039A9C09" modified="2014-11-26" version="1">MNRAGFDKYITVFSPEGSLYQVEYAFKAVTYPGLLTISIRCKDAVLVVTQHQIPDRLMRPDSVTALYEVTPGIGCCMTGRAPDGRALVQRAREEASDYHYRYGVPIPIAVLAKRMGDKAQVRTQQAGLRPMGVVSTFIGMDQSDEDGLLKPKIYTVDPAGWTGGHIACAAGKKQVEAMAFLEKRQKSTEFDTLTQKEAAMIALAALQSAIGTAVKATEVEVGRCTAANPTFQRVQNCEVEEWLTAVAEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1G9</accession>
    <name>A0A088S1G9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">YEATS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_331130</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702205.1">
        <property type="nucleotide sequence ID" value="XM_010703903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1G9"/>
    <dbReference type="GeneID" id="22578266"/>
    <dbReference type="KEGG" id="lpan:LPMP_331130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330016400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_331130"/>
    <dbReference type="eggNOG" id="ENOG502S6NG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10053467at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005033">
        <property type="entry name" value="YEATS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23195">
        <property type="entry name" value="YEATS DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YEATS" evidence="5">
        <location>
            <begin position="8"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="94"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="390"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO01405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="444" mass="48331" checksum="4949B2A4AD66F494" modified="2014-11-26" version="1">MSAESQRVVYGATFDIPYAIGSVSVPLDALAASSPPRVVPQEVNKAGPSPSSSCRRGLSSGNISSVRRCTHHRYCYVRDGGDLSQDAFYRWLEQQQQKHREGAHASSTSSPPNEDPGRPLTPTMGITSTNATSSALPDAPTSPSLFYASVKCVVFVLPNSFPHPRRVLRHPPFIIEDDTWAEHLVEVQLYFWPHLKIPPATVVHQALLERRLSLGPSTQPSGAVSAAAPAEDVREVWVPQLLASTYGKPKLLSVATNVTVRVPAHHATATAPDTTKAASRMVVVAEKVDTLHLYHPSLDVVRHIRAVLAMSRLPVLEAVREAFDAAYSTPPPMNANGSSHSATSSTLTDVEVTPGVAVDTSLSTPFAHSWSLPFEDTIAEYAEQRASTSVAVLQAVLEKLKRERQEMEKSCEGSMEQIGELATVALPTQLQRVHTRCMKLYRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1Q8</accession>
    <name>A0A088S1Q8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_350090</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702949.1">
        <property type="nucleotide sequence ID" value="XM_010704647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1Q8"/>
    <dbReference type="GeneID" id="22579038"/>
    <dbReference type="KEGG" id="lpan:LPMP_350090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350005800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_350090"/>
    <dbReference type="eggNOG" id="ENOG502RR8S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270594at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044189">
        <property type="entry name" value="XPO4/7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596">
        <property type="entry name" value="EXPORTIN 4,7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596:SF1">
        <property type="entry name" value="EXPORTIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO02149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1055" mass="115528" checksum="F72635AF944619BF" modified="2014-11-26" version="1">MRVAMASHIEQAAACLRCGNHNGAAAALRELEVGEGGRSLQTAVECLMNKDGVSDDVYVRFVAFKVLAYALTRCRGGRWQQSDTTVAFLLGYAYQMAEQVETYTWTPVVSELATATAVALKLGCVGDNLDVCAERVTTACSGLVELVQTCTPSSKAYLHRIICQSIVEEFGLFSGASRYRGLPVRVHRRCRELFAAEDRLPTLIQALVRGLLVSVGESSMSVDKGLTALVSCFAWPSHQFFEEDSSTEESCSVFYVAHEEWDRLLVSDMALPNGACVTMHSVLREWYACGAVNGVPVDQKKVIEVIQLLCSFKGSEWMEGQTLRFLVSSLSLCLDVFEHLSQGATDGDFHLFPLLANAILRLVSNYVEFFFHPQTHALISRLASLTSFLIRRDTSSSTNTDVMSCVDEMLSVWFHLTSYIDRSSFSANASETIAQVHLISKGCQFIFSTYLDTKVSTDAVELEVDCFADTFTASHLHLIAQVGRVCATNTCELLIQSLRSLRATLASILGAGDTVSPTLLEAIWTLLKIIGFFIADPLEGEQPYIPRCFLVMASEGSPLLLHLVKEVDPLLPLLQNPAVASPAVHTAFLDIFTHYITTYVEAEESCALYIDAFSGGADMVAQSLLAVVGVLRAAPFEEEATSAVCRLLDCVADKSSRVRSFCLNQEAFQGLTRTVQDIHRFRFYGHTRGRLIAFVLACCSDADSVQAHLRKFTLSPSFEADVNLVLELLSSLAGLFESLHNQQVIRCVFPTLLATGQQLIAVSASKFCELEIVIEFVQCVRNMFVTCSPLLEDNDIRALLDLVVAELRYSVTVLQTTSVWRSADGEADKAEFIISAARLLCSLAQWKALDCFLSEEDIRAVSTAVVETAGALLRATDERLLSLPSLEDCIFTCIELCAESFTSDFVFANCSDVFLSAMLYALNSERVNIQRVGISVTANVAAFLEASTPLVSNTSVCCDLLKVVLRALTSGKVFCNNLRQIARVLLILVRGMSYDSLVAALEAVEREVSNCDSFLAIIFPALQLVVEHVNTSESAFEELLQDALSSVHGTTIMGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1U1</accession>
    <name>A0A088S1U1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_350550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702994.1">
        <property type="nucleotide sequence ID" value="XM_010704692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1U1"/>
    <dbReference type="GeneID" id="22579084"/>
    <dbReference type="KEGG" id="lpan:LPMP_350550"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_350550"/>
    <dbReference type="eggNOG" id="ENOG502S1VZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269332at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="210" mass="23770" checksum="3B7ED5C631F53D0F" modified="2014-11-26" version="1">MGFLGFSGDSSESYSLSDNSSKVDDRIKLTYAETVVSLATAFGLVIIVLLDLLYRSTFRHAMLLRVQRETRFDGAYILGKPEGSRARIILENGLKTHAFRIIDPPQYSRVVPAVVSESRDAKKDCVEMLSKVRTILAKSYGRCAELMSMRCCLACVTGALPAEQSERFLRIYERVMFCSHRVNGDEKLVTSDDIRYMHAFFYNNVLKVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2C6</accession>
    <name>A0A088S2C6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Developmentally regulated GTP-binding protein 1, putative</fullName>
            <ecNumber evidence="5">6.1.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_352340</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.1.1.3" evidence="5"/>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703171.1">
        <property type="nucleotide sequence ID" value="XM_010704869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2C6"/>
    <dbReference type="GeneID" id="22579263"/>
    <dbReference type="KEGG" id="lpan:LPMP_352340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350029800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_352340"/>
    <dbReference type="eggNOG" id="KOG1487">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="603at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17230">
        <property type="entry name" value="TGS_DRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000003">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000740">
        <property type="entry name" value="Putative GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="64"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="289"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO02371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="368" mass="41097" checksum="25B50BFF2EF3336C" modified="2014-11-26" version="1">MSSLQKINDIEAELARTQKNKATMAHICALKARLAQLKRELIASESKKGGGKGEGFDVQKTGDARIGFIGFPSVGKSTLLSKMTSTHSEVAAYEFTTLTCVPGVVNYRGAKLQMLDLPGIIEGAKDGKGRGRQIIAVARTCSLILIVLDVVKPLQHKLIIERELDGFGIRLNKLQPDIVIRKKDRGGISISSTCPLTQLDQETIKTILGEYRMSNADVTFRGDYTADELIDAIEGNRAYIPAIYVLNKIDQISIEELDIIARIPHNCPISAHHEWNLDGLLECIWDHLNFIRVYTKPKGQVPDYDAPVILKKLPQPSVEGFCNRIHRQLMHNYKYAWVWGSSVKHQPQRVGKDHLLDDEDVVQVVKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2E1</accession>
    <name>A0A088S2E1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Caltractin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_352490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703186.1">
        <property type="nucleotide sequence ID" value="XM_010704884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2E1"/>
    <dbReference type="GeneID" id="22579278"/>
    <dbReference type="KEGG" id="lpan:LPMP_352490"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350031500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_352490"/>
    <dbReference type="eggNOG" id="ENOG502S9C9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO02386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="231" mass="25236" checksum="FD8EED71B41C0512" modified="2014-11-26" version="1">MQDVRRALYTITGQRVTRSELLKLIAFAQDAVAKQQQAMQHQQDQVTCLHRPKMASPEAQGSPSVTTITDGEVMSFSGNIRSPSQAGASISTLSVRAESPMNPQAAAATEASTPAPTVRNQICFVSPRSHLLDSSEGIDLDVFEQIVLRKLKHRNYEEELAYTFALLEDKSYLGFITKESVRRAATETGEALTEAEIAEMFDPLVTGVSTAAVDLSTFTDLQLKARKAEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2M5</accession>
    <name>A0A088S2M5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_353340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703271.1">
        <property type="nucleotide sequence ID" value="XM_010704969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2M5"/>
    <dbReference type="GeneID" id="22579363"/>
    <dbReference type="KEGG" id="lpan:LPMP_353340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350041200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_353340"/>
    <dbReference type="eggNOG" id="ENOG502RYZ3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="243965at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005813">
        <property type="entry name" value="Ribosomal_bL20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035566">
        <property type="entry name" value="Ribosomal_protein_bL20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10986">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74731">
        <property type="entry name" value="Ribosomal protein L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO02471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="194" mass="22461" checksum="7DD7C74EDF80A2CB" modified="2014-11-26" version="1">MLRLTGTSWYYRATAELDRLRGMLRGRARLERKVGLKRITFLMRTQTRYRVEYKAHWERAIVRKNVDSAAHEHGSGWQHLRNDLARQNLMLLPRTQQQLAQYEPLAFRAVMELCASRVAPPPPPMTAQVPEEAYATRPEDPLVAHPAARRQLKEAVERMLCAGRSEVLQREGPRATLTWMDAWKEYDVGATTPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2M9</accession>
    <name>A0A088S2M9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Actin-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_353390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703276.1">
        <property type="nucleotide sequence ID" value="XM_010704974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2M9"/>
    <dbReference type="GeneID" id="22579368"/>
    <dbReference type="KEGG" id="lpan:LPMP_353390"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350041800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_353390"/>
    <dbReference type="eggNOG" id="KOG0676">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="407" mass="43494" checksum="B5D36311D5644CC7" modified="2014-11-26" version="1">MPSASADVQSVVVDVGTRNTRVGFSGEEAPRTILRSCVGLPCTKRPRPTLLQHPFDIVAGDAAYQDGGLLALTFPVRTGHVHDYDALEKLLLYALVEEARVPPDASPFLFLEPADHSRLDRERLCELLFESFNIPLAGLLTNTAATLYSSGRTSGLALDSGAGRTCVAAVEEGYTLAHSVRSSSIAGEALTDELFAALRADGYPLSTAADRDIVEAAKEALCRVSADAKDEEAQQVGTHDHPDPADGFVLPDQERLFLLEHAYKVPEALFDDTYLTYTTDTSAGIPTTPTGYSQSNHVVKKTLGGWVGMLRDAAATAPRFLEQTLYENVVLGGGNTLFRGTEQRLQRAIAAVAPTGAQATCVAFPERGAAAWVGASIWGCSSVFPDTCLAKATYDEQGSSVVHLYTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2R8</accession>
    <name>A0A088S2R8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_353810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703316.1">
        <property type="nucleotide sequence ID" value="XM_010705014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2R8"/>
    <dbReference type="GeneID" id="22579409"/>
    <dbReference type="KEGG" id="lpan:LPMP_353810"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350046100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_353810"/>
    <dbReference type="eggNOG" id="ENOG502SGRQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270414at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO02516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="194" mass="21487" checksum="52DEB51197CCA486" modified="2014-11-26" version="1">MLRFCLALRAASVQRKPHLFRIDLTSKHTPGRLYLADRAVKSTAADPCFVCLDNAMACQTVDSNAAVVLRSCTTKDRELFQYGRMRFQGMSRALVFRHNHLVFQGIGDASVQTLEMSLHYNDIFALLGGIGADENISEWVRAVEKAVAEGDVEYVAEEMLLQLRCTTEGCTSVVAKISKFSTGLPEPPSYSHPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3B6</accession>
    <name>A0A088S3B6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Archaic translocase outer mitochondrial membrane 40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_344710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702890.1">
        <property type="nucleotide sequence ID" value="XM_010704588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3B6"/>
    <dbReference type="GeneID" id="22578976"/>
    <dbReference type="KEGG" id="lpan:LPMP_344710"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340054900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_344710"/>
    <dbReference type="eggNOG" id="ENOG502RMVC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275379at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="38659" checksum="C91405E3A0E4F7BE" modified="2014-11-26" version="1">MLKEWLRGSSSEAEKPVEKKPVSRMVVDAEKPLETHESAASKRRELYEKKLAESAKEGPPHPSKTVTYDGIFRKTQGVLLEGNNNEIQEGITLNIARNAQNTMVSTKWALVNPQMSHWEVNLQMNGFSDIVAASWNTLNRYQLMYQRVFSTGAMLVTQFMAQKQGGLSQGTVFAMMQYPWRFGGCTQVQYVKDQSLSLSHVQRLIRGVHIGTNLTFEPATHSSYLSHAISLMTAKRDAGFMAEMTPSKGTWKIAATAFDWAVNMDAAIELEYMEGRESMKSALNVGCRKSFVGGAQLTTSLLGFNIAKVNLDLPFGGEVPGTNQLRLTFNCQYDIHSGALKQGLIFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3D2</accession>
    <name>A0A088S3D2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_344860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702905.1">
        <property type="nucleotide sequence ID" value="XM_010704603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3D2"/>
    <dbReference type="GeneID" id="22578991"/>
    <dbReference type="KEGG" id="lpan:LPMP_344860"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340056500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_344860"/>
    <dbReference type="eggNOG" id="ENOG502SG1T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266165at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="494" mass="54662" checksum="D4005AB1FDC78B1C" modified="2014-11-26" version="1">MAYGKITEFELDAPTFIHAMIPTTRKQNCHRLLQRVATTRCALSQTLSRPSSVRSRGRDISVAEDDYVARLEGQLNACDASESPRSPEAQSSWQRQRSASLMTTLHAPHRPEGRDSVRCRQSFRSTAPSPHVTTLTKEWVKKDEEKAAMALSKGSTEAHTEDSLLAIPTYCTFPSRVGQSSTNSCEARLHRGRLKSFAGPSASNRSSAAAVGEYNAQGSTAQPPRRQRLLAKPIQSSLLLKDVMTTPVQLTRSSNASLLGSARIRCDTLERLRHGFVHQCIVLQSELEEKLEWRNRCRSALLRRNRPVDGATAVSTHSPASATSTLRAAGVNALHPKMFDEVFGSAAGFSMRLQRRSKLPQFSSFALHSVWSQEAARQAVQQEKHRLVDLLESFVVTCSAAALTLAATEELRAETIRRVWHPEGGGGSHNTSFLHCEQFLKFLQGRYELHTSQLLGAAEAMCPTDILDALPSQAEASFARYAYEILPSRAERRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3D7</accession>
    <name>A0A088S3D7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_356150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703544.1">
        <property type="nucleotide sequence ID" value="XM_010705242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3D7"/>
    <dbReference type="GeneID" id="22579643"/>
    <dbReference type="KEGG" id="lpan:LPMP_356150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350069900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_356150"/>
    <dbReference type="eggNOG" id="ENOG502RGYD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="262894at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012609">
        <property type="entry name" value="Spore_V_M"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08183">
        <property type="entry name" value="SpoV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="596"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="676" mass="74488" checksum="2B3F811D19BBCE59" modified="2014-11-26" version="1">MIQLDFVLYRFTCDISAFTGLFAEDAEGRHIPDVASFHCTWTHTPRAKPSPSSTAAEHYVNGATDDVHFKGLGTDMALLFPKLSHQLILDGMRDVITFAIRPSQYSAAGPLPVVAKGALDPRPYLGKPMKNYAIKLRDAVGGVVGKLLFSLRVHELDEEGQRAMPSDMVTSTALTSVPRNSPDRAQRAVQQDPSRDRLLKMPPSGERRVHLASNVVERQEAAPQQTYVATSQRSSPCRQKSRPSQRGVSVVQTMDILLERVAVKTTSIDLDHPAPLLLGGEYHMKIRYGTYTFSTTPAVCTNPKEVVYKEQQASITLQPAGSTEKLRFSLWEGKRQVAGFSLDPAKFKSDVGEWKEYAIPFSYHPTEQRSALDVRVRRVETDCSGFLSDWCAPSQPSPAPTAFSTIADIDTTRASRAVTQPSTYDTNPSNWYAEEGARRQTPLRFSPSPNRYVGMNLTRSEGPLAHACSSPSSNRGAFSLPDSITATLGLVPPLNANRTSTPLRAFDPCAESASQVMSGYRGAHVRDASPVHGGWERTPMRPRPPPLTSNLADLPADLRPPNEHEMYIAEVLARLDRQKGTARQQTSLMEDWAGWRNDPERSRCNSVSSMHLRSPSANSATSRADSMASVVSRRAVAPRPTKSNADNSVMLPFTPDTSVYRRRRSLPSSNPFNSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S543</accession>
    <name>A0A088S543_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U3 small nucleolar RNA-associated protein 25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_140400</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UTP25 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697274.1">
        <property type="nucleotide sequence ID" value="XM_010698972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S543"/>
    <dbReference type="GeneID" id="22573307"/>
    <dbReference type="KEGG" id="lpan:LPMP_140400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140009200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_140400"/>
    <dbReference type="eggNOG" id="KOG2340">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264378at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010678">
        <property type="entry name" value="UTP25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053939">
        <property type="entry name" value="UTP25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053940">
        <property type="entry name" value="UTP25_NTPase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933">
        <property type="entry name" value="ORF PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06862">
        <property type="entry name" value="Utp25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22916">
        <property type="entry name" value="UTP25_NTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UTP25 NTP hydrolase-like" evidence="6">
        <location>
            <begin position="637"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="domain" description="UTP25 C-terminal" evidence="5">
        <location>
            <begin position="877"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="566"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="266"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="566"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN96621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1063" mass="120990" checksum="177DE4D4E29C069B" modified="2014-11-26" version="1">MGRPSGFFRRLKAKEKRASSRKQRGTKGASKEERRRKHNERVELYAAKREAEQLAEVSSSSDDEPSTDSDAEEYRQTKSLRRLQKMLGVTSPSDPQAASYKRSRRQPTSASRRDDTHADEDEKVADGWNSCADDDSDNANARESLSTEGKQNRRPPPQRRRARHECAQAKASAACGDDDDADVDGEDWRLYLGAVSGSGDDDDDEGADGEEVTELGEETDDADNVVDTDLLMDMGDSDDDDDSVGKDEENENDDNPLFDLERSDGDAQEVDDDDDDGADLFDDAMMYDGEEEDEEEGEEREDIYVDDEDDDAAAGKERETDSQERLLLQSFQFNPSTVSILRQCGAVGEANGAKDNSSSSVLTERDEWVRKYHLNLHGALDETPLKPLPVPHAALELLAESNKRLQARAAERLKTTKDKKDLGIFFASPEEFAAVHPENVAVLATAHAQQHLLHAPFDVQRCAASLPPLSAPQAAEPWTACPPYLHPLLWEKWAAFRAGRNVPTFTAEERGLLDLLQGYADLLDTLHCWQNSESRREIFALHLLNHWFKARSVVLAHDTLLAKRQEAQRRRRCRDQQKRQRRHNGGTLDSDAFSADAKWLTQQSSTRNRGRQAKGKAPVSQQNKPEKEVTKSDEICCEADSEQQEHNLDTDDQELELRDRGFSKTRLCVLCPLRNHAYKFVYSLVSILQADPSRCPKLAMFEQDFTEIEEAVDPTFKRRPRDYQRAFEGNIDDSFCVGLRLEPDRVHVYSHPLNSDLLLCSPLGLRRRIEKNGDVLVSLSSIEVCLLEDAQMLFQQNWMHVTAVLELLNKRPTDTTHGLSDLRRVYAWVLEGKSGRHRQTIMSTNVCNATMLATFRTASVNNSGKLLLQRRADPGVLSRVLVPVRQHFIRFDPGSLATVDEDRFEFFTKQVYETKINAMAERDVRVIIFVPSYFDFVRVRNYLHREYRESYVALCEYTSLKQQRKALGQFSDLERPVLLVTERFYYFKRYFVKLAEALLFYSPPMFPEYYASLANRLVSTSPNAFTMTLYCRYDTHELNRLVGTSRMVQLLERDSGVFSFVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S5B4</accession>
    <name>A0A088S5B4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glutathione synthetase</fullName>
            <shortName evidence="9">GSH-S</shortName>
            <ecNumber evidence="9">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_140880</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9 11">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="9"/>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697319.1">
        <property type="nucleotide sequence ID" value="XM_010699017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S5B4"/>
    <dbReference type="GeneID" id="22573355"/>
    <dbReference type="KEGG" id="lpan:LPMP_140880"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140014000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_140880"/>
    <dbReference type="eggNOG" id="KOG0021">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2020073at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004887">
        <property type="entry name" value="GSH_synth_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03199">
        <property type="entry name" value="GSH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001558">
        <property type="entry name" value="GSHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="3 9 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 9 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathione synthase substrate-binding" evidence="12">
        <location>
            <begin position="289"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="498"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="533"/>
            <end position="536"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="561"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="587"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="589"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="595"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIN96666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="632" mass="69807" checksum="5AEA8E63D9EA5BB2" modified="2014-11-26" version="1">MATTATTTAATAAEDILEGLPSEEELAAKCLQLGLAMRQPPTYHVTHPALSLRPLPMKVEVLRELYGLQLLWNEAINRTARNFEFLRDSMRSTAESDRDFTGRLLSILERVYMTTPDGAKAPVYQPLMLGIFRSDYMSSVDSESSSPVSPAEAAASVTLSGAAAAAVATETSRQWKNIEFNTISCSFAGLSPLVQQFHAYLQKFREADMNARAAADLEHVEASSLSTSSVVAALPHQHAPAYVPDQMHSSAVQVPAALAKAVAAWRSAVPCAGFLRQYQHRTGVKLKPIVLVVVQKNEMNTADQYKLLLELLETHRVLSLRRTLAELHETMRLEHANLGESRCDHSTGTKEVVSEQLQPPFLVLEGKYVVAVTYFRSTYVPQDLPTDAAWQTREWIEESNAVKCPSIPYHLMTFKKMQQLMSNVSEVLAPVSFAGDQQKAAALAEHFVPQYSLNKDEYGRSGENQQCNDKDKVIDDPEYWIADAVEHLERYVLKPQLEGGGNLIAGEAMQRLLRDAKSDDPLYQKIRREYILMRKIHCPVMKGIFFRQNQIHVVESNVSSELGIYGVTLSSDANQYIMNEAAGSVVRTKPADVADGGVMAGIAALDSVQLIDEAPHEVAWSGASAVADERYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S5X8</accession>
    <name>A0A088S5X8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_160720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN96946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697599.1">
        <property type="nucleotide sequence ID" value="XM_010699297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S5X8"/>
    <dbReference type="GeneID" id="22573650"/>
    <dbReference type="KEGG" id="lpan:LPMP_160720"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160011200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_160720"/>
    <dbReference type="eggNOG" id="ENOG502SMBC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273102at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="607" mass="64951" checksum="7259D38C91F8AA04" modified="2014-11-26" version="1">MFRGHWIVADMDGTLTPTPTRAHGKYLTLSHCMQTGLGCGAHYKSCLPWLRLFLELGGTLCVVSTAGKRMWSQLYPDLAPALFRLRAAATAAGAAAAGGNDAPSGPSPPIGSLDAPGTLYLCGFTGAALFRSRPWEAVWSDMDRLHPHWRVPSAPHPSRFDEDERLQKGETAVAVAEVPPSGVALEEWTEYREQGVTPGTADSQATSSGAASRIATIDAATCMLAMDEGRQALVRFFEHSSYVCGHDAARAKDFFAACLSTKYHSVFADLLHQLLAEAHVTTRRGGDGASGAHTGTPHVCFAASKVLSSAALAKHGFFLRETGDALVDVQSVPRADGTVADDAAVAQVIVMGIPMRFSNHVFPATGSSPFNSSPATSRDWHCCPQCAAAGAGARQRLEAAGLELKSQPNSVCLHRRGVDKATCVRWLLAQHERHQLLFKLSQALAFGDMPESVDAPLTAFPPMQFISLSPQDDAAARLANIERAAVAGSTSADETGGQGERQQQPPPSGYLSDGAHYMFHVGGEEEGTGLFLEELLVSCTSEQQRSAASSSTAAADATRMANWFTADRVAVCATRARRRMEEELLRRRRQQQERSTARAQGTTHPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S684</accession>
    <name>A0A088S684_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_170330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697724.1">
        <property type="nucleotide sequence ID" value="XM_010699422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S684"/>
    <dbReference type="GeneID" id="22573776"/>
    <dbReference type="KEGG" id="lpan:LPMP_170330"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170008600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_170330"/>
    <dbReference type="eggNOG" id="ENOG502SKQM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267303at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="781"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="814" mass="85541" checksum="A0F8C27C162B815D" modified="2014-11-26" version="1">MGQAASYAESSVQRALLRLKEEEQADEDELLCACGYSRASLSSCTNGSAATAAQSRCGAESAGSSLPVTRSPDVHLPPPPESFGPLVSLTPEYYTLDELRDVLRYLPDPLWVSLYRVSLLYMLDNDHDGRINSTDISFFMDWGIKTVGRDVLPDQLAEVLQTYAALHCWHRCLHVAECIESERAATAATAQPRPGHRRSAGAGSSMRTHRRPISSSGAVGGDTLSLHQRAQRRPNQSVSSFMLLHFREAFLNTPAGGPVPLPGAIGIAAMNADVDNMSPSQSSALFESPRSAISQPVTDSVRYAAATHFAEWMLRVVQNQERDRRHERQFFERRVRCMATTAEVKLGNTTRLRHPSYVAQQSLRIRLSTSFLPAEAASADVPGEGDDLVVSVSQSSISGRQTSMISGILNGSAAVVAASSDADKATPELGVVPLTSAPQLPTSLSFEGPTAASATRLPHSPGTPAALKAFVKTLPHTSSHSRSAMPLSVPVALGGGGSGSPEGTRSPRSPRSPRSPPPTTDAGILPPIGSGSPDSHRGTAAGGPLFTGTSPAHQPSRPRQSAVAPTTQSMPSGGPPSSGHLDAAETAADLPAGASANANGIGISGKGEVEDGSFSNDNACSSSSSLASAAAAGAAATTAAATTTPNSGSAAPLLEHQVSVLLMDAEAFYVQLEATGWCTIGAVEEVYLDFAVEESYCMPFWSFCRLLNQASADEVQAALELPTDQAVAVLTSAAAVEEYRQAAAVRQLQRHVPGQRDGGSGSNNRYCGSVHGSGWASHLQLIPMFVVSEYTFVVFVAAFIHAYWAMLESMGVDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S718</accession>
    <name>A0A088S718_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Qa-SNARE protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_190090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698004.1">
        <property type="nucleotide sequence ID" value="XM_010699702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S718"/>
    <dbReference type="GeneID" id="22574063"/>
    <dbReference type="KEGG" id="lpan:LPMP_190090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190009200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_190090"/>
    <dbReference type="eggNOG" id="ENOG502S26F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="364348at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF38">
        <property type="entry name" value="LD27581P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="2">
        <location>
            <begin position="133"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="228" mass="25988" checksum="64D0DD5CC60F0A3B" modified="2014-11-26" version="1">MPLENGEVLSRSIQQVAKACSDAQSSMKELGTGRDAIARDRLHRIRLLVEQCSIRVEAILSDTEPSLEALKQQYMQYKAAFEFINAEATRRERQIFLQTDLDSVQKGDLDAVESQVTFCEVRPLDMSEFHTEEAIQREKLQNAREIESDVLDLKATYQEFHSLVHQQQENLDRMTNNVTESHSLIERGHDQIQDASSRQRSFRKLGCISGTVVTVIVVIIIVVVALTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S818</accession>
    <name>A0A088S818_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein phosphatase 2C-like protein, putative</fullName>
            <ecNumber evidence="7">3.1.3.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_202220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7"/>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698423.1">
        <property type="nucleotide sequence ID" value="XM_010700121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S818"/>
    <dbReference type="GeneID" id="22574431"/>
    <dbReference type="KEGG" id="lpan:LPMP_202220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200027600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_202220"/>
    <dbReference type="eggNOG" id="KOG0698">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF837">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="6">
        <location>
            <begin position="117"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN97716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="396" mass="42911" checksum="B709867FA5552E4E" modified="2014-11-26" version="1">MSLRPVHQAVSIELAIDMIHDSRSPHHKSRLSDSSSCFPPGYLNRDSFDLNSLTDHRLTDYSICGPVESYPHYLLPRELRTPAQHFTQEIPHNSSHSSLCSAFFSSVSDMQHQSVREVGVASDQGIRSSMEDEHVAVVEPEVCFFGIYDGHGGRQCAEYVRSRLHEITLTHESLKTAPQKAISDAFAQVEREFLEQNTSNISSAGCVCAAAVVQGSVLTVGNVGDCEVVLARGGKPVLLTVKHNPSCNDAEATRVKNAGGCIFNCRVGHPRLNPRMCSLAVSRAVGDAGFKLEEYTNGKPSGIIAVADTSEVLLAKEDAFLILACDGLWDTMSYAEAVDLATAYAASGADANGVADQLVREALRRGTRDNVTAIFVRLGWSAHAGLDEDEKEVQHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S8T0</accession>
    <name>A0A088S8T0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_205450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN98036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698743.1">
        <property type="nucleotide sequence ID" value="XM_010700441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S8T0"/>
    <dbReference type="GeneID" id="22574757"/>
    <dbReference type="KEGG" id="lpan:LPMP_205450"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200061400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_205450"/>
    <dbReference type="eggNOG" id="ENOG502SJRN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273763at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="688"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="785" mass="81420" checksum="2D48AA5B8968DE64" modified="2014-11-26" version="1">MGAGSSTASAGDAGVPLPTCPLFYNFMPNAQLIPASTLPTRGPDGLLCHPQGGCMARVIQLRSLPVVSEDSKRCAAQIIADAKKKKRGGDSTADREEANAVAAANDLLRNPSLHPSLSSCFLLSIAVDEQGRLVPLSTGDEHGVNAMAGGGGDGAQLATSKMSEKLTSPRSKIVKKGFSFSVFSSTVRTPLALGEGGSCEDSVAGTPRPLRGGNNGAAATKLVSVLSPVHASVNAGSHPAGDALLPDPPSPHRSEAMPRWRSPTSDSGGDGAQLASSKRPKGLTSSFASPPPSSAGSSNAACDTTIEGKQGTPLVTIPMCSVLAKQSHFRKPEEGQGRESTSVASVLPNVGATGGDGVIPPRIRRQLSRITLLRVPQRTRWFLFNDSRTHEAQVSALLCYRAEEKPTNQKNLIPGEETPMDSSGRTITAATPVPGDLRICCRPTPLSHTSLSSKEMKLQLQSMCSSTRSYVEVQPMAVEVLTAAIPAPKTPMEEEKLAEFKKRASGAAAVEVFVVLAPGATVYLAEGEVLGYKIDTHLVPFDKLASIAVLGRMLTPELVRNLKKKGESVNVKGYRHKLMFLAKPTETTAGAASAHGSSLAPACLTGSAMAPPPTAAARGTPKDANFIPPLSSDTPNVSPPDLGRSTISVTSATALTDSAGHAADATVAAAKTSAAPYWNRLSLQRRCKTAEKSANDENHSEGAGNPSSYNAPAAAAAVLAWPAADTTATRAGEMGNAAGVLELPVLGIKSLIDDLDKDCSIPRSHAPLEGGQLYSTSTSSLHISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S962</accession>
    <name>A0A088S962_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Metallo-beta-lactamase family-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_210700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698858.1">
        <property type="nucleotide sequence ID" value="XM_010700556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S962"/>
    <dbReference type="GeneID" id="22574892"/>
    <dbReference type="KEGG" id="lpan:LPMP_210700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210011700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_210700"/>
    <dbReference type="eggNOG" id="KOG0813">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="17458at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07722">
        <property type="entry name" value="LACTB2-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000041">
        <property type="entry name" value="Metallo-beta-lactamase domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047921">
        <property type="entry name" value="LACTB2-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041516">
        <property type="entry name" value="LACTB2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050662">
        <property type="entry name" value="Sec-metab_biosynth-thioest"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131:SF0">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17778">
        <property type="entry name" value="WHD_BLACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="5">
        <location>
            <begin position="36"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN98151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="333" mass="36730" checksum="3DCBA3372696CC8A" modified="2014-11-26" version="1">MHAGTGAEVAMPVIATLSSRVVRIMGLNPGYMTLQGSNTYLVGTGQERLLIDSGEGVEGYGDLLQKAVVQESTRLGRPVLISKLLLTHWHGDHIGGVETVRRIFPQVQLLKQPSQYVPTRVDALCQVPPEVVKVEGATLQLVHTPGHTDDHLCAFLQEEGALFTSDTVLGTGTSVFSSFKDYMNSLHVLKRIKPKRLYPAHGPVVEDGTARIEEIIQHRNMREEQILQVLCERTHESSAPDHDKGLSIRELVDTIYTTTPDALRTAAGINVFHHLKKLLSEGRVMVRYVPEDLVYFLKDVTDYTAFGEGADDSVKVMERILTELRVATAGVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S9J3</accession>
    <name>A0A088S9J3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GMP synthase (glutamine-hydrolyzing)</fullName>
            <ecNumber evidence="3">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_220110</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="3"/>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699013.1">
        <property type="nucleotide sequence ID" value="XM_010700711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S9J3"/>
    <dbReference type="GeneID" id="22575057"/>
    <dbReference type="KEGG" id="lpan:LPMP_220110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220006200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_220110"/>
    <dbReference type="eggNOG" id="KOG1622">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1724632at2759"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003921">
        <property type="term" value="F:GMP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000027">
        <property type="entry name" value="GMP synthase (Glutamine-hydrolysing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000008">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000044">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018317">
        <property type="entry name" value="QueC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922:SF2">
        <property type="entry name" value="GMP SYNTHASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922">
        <property type="entry name" value="GMP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06508">
        <property type="entry name" value="QueC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54810">
        <property type="entry name" value="GMP synthetase C-terminal dimerisation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 13" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6 11" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="4 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="12">
        <location>
            <begin position="202"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="230"/>
            <end position="236"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIN98306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="656" mass="71372" checksum="B4E3927AE1E7971E" modified="2014-11-26" version="1">MSLQGAPQGEYIVILDAGSQYGKVIDRKVRELRVETKILPLDTPAEKLCNDTKLMGVIISGGPTSVKDETALAYDKAIFAMRKPVLGICYGMQMLTGLYGGEVCRGRVREDGQDSIQIDTSSPIFAGLDSTETVLLTHGDSITDTGTELKVIARSSAGIIAAVQHQSLPLFGVQFHPEVGLTVSGETIFKNFLKLCGCKFSFTMEDREAVALRLIRERTSNGQKVLCLASGGVDSTVCAMLLLKALGPERVVCIHIDHGFMRLHESAQVVEALNAAGVRVHLVKAQDNFATASTAMTAKRGRAAYTTNKLCETTDPEEKRNIIGNTFMSVCDRVVKELQLDVENLLLAQGTLRPDLIESGSKYASANADAIKTHHNDTAVVRVLRDAGRIIEPLCDYHKDEVRDLGVRLGIPRHLIERQPFPGPGLAIRTLCTDGTPFRDANFADTEATVKRLCMGDDASFAEVAAFVQSVALSACILPVRTVGVQGDGRTYAYASALSMQTFPTTEQWVALMQLAKAIPKTAHAVNRVVFMFGPPQSESPSSVTRTYLTTDVLDKIRVADDKVNGILMKHQLVRSLSQVPIVLIPVGFDKTGCYSVIVRTFLTNDFMTGIPATPGSAFMPLTVLKEIVSELEKLEFVSRVMYDLTAKPPGTTEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SB09</accession>
    <name>A0A088SB09_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Transketolase</fullName>
            <ecNumber evidence="4 15">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LPMP_242040</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 15">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10508"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <text evidence="15">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="12">Binds 1 thiamine pyrophosphate per subunit. During the reaction, the substrate forms a covalent intermediate with the cofactor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 15">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="4 15"/>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699543.1">
        <property type="nucleotide sequence ID" value="XM_010701241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SB09"/>
    <dbReference type="GeneID" id="22575613"/>
    <dbReference type="KEGG" id="lpan:LPMP_242040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240027700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_242040"/>
    <dbReference type="eggNOG" id="KOG0523">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10267175at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07033">
        <property type="entry name" value="TPP_PYR_DXS_TK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000003">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000003">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000004">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055152">
        <property type="entry name" value="Transketolase-like_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005478">
        <property type="entry name" value="Transketolase_bac-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049557">
        <property type="entry name" value="Transketolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00232">
        <property type="entry name" value="tktlase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="TRANSKETOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522:SF2">
        <property type="entry name" value="TRANSKETOLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22613">
        <property type="entry name" value="Transketolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 13 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 13 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12 15" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5 15 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="16">
        <location>
            <begin position="350"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="409"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="114"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="518"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="14">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="14">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AIN98836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="671" mass="71640" checksum="FE54CF1C3535303C" modified="2014-11-26" version="1">MASIEKVANCIRCLAADIVQGGNSGHPGTPMGMAPVSAILWTEVMKYNSQDPHWADRDRFVMSNGHACALQYALLHMAGFDLTMDDLKRFRQEDSRTPGHPERFVTSGVEVTTGPLGQGIANAVGLAMAEAHLAATFNRPGHEIVNHHTYAYCGDGCLMEGVCQEALSLAGHLGLEKLIVIYDSNHICIDGSTDLSFTESCTQKYVSMGFHVIEVCNGDSDYDGLRKALAEAKATKGKPKMIVQTTTIGYGSSKQGTEKVHGAPLGDEDIASVKTKFGRDPSKKYHVDEDVRSVFQKHVEKCAMEQKAWEERLAKYMAAFPAEGSAFVAQMKGELPAGWEAKLPTNCSPIATRKASENCLAVLFQAIPALIGGSADLTPSNLTRPASANLTDFAPGSYEGRYIRFGVREHAMCAILNGLDAHGCLIPFGGTFLNFVGYALAAVRLAALSHHRAIYVATHDSIGLGEDGPTHQPVELVAALRAMPNLQVIRPSDQTETSGAWAVAVTSARTPTVLCLSRQNTVPQPGSSIEGVKRGAYPLAEVPNPQLVIVASGSEVSLAVDAAKALSGELRVSVVSMPCQELFDAQSDKYRKSVFPDGVPVVSVEAYLSFGWEKYSHAHVGMSGFGASAPAGALYKKFGITTGDVVATACKLVARFPNCTAPLKNSSFSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SC09</accession>
    <name>A0A088SC09_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ferredoxin-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_261030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699923.1">
        <property type="nucleotide sequence ID" value="XM_010701621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SC09"/>
    <dbReference type="GeneID" id="22576006"/>
    <dbReference type="KEGG" id="lpan:LPMP_261030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260015200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_261030"/>
    <dbReference type="eggNOG" id="KOG3309">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268593at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140647">
        <property type="term" value="P:P450-containing electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001055">
        <property type="entry name" value="Adrenodoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018298">
        <property type="entry name" value="Adrenodoxin_Fe-S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426">
        <property type="entry name" value="FERREDOXIN/ADRENODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426:SF63">
        <property type="entry name" value="TRANSFER PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00355">
        <property type="entry name" value="ADRENODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00814">
        <property type="entry name" value="ADX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="6">
        <location>
            <begin position="41"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN99216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="157" mass="17195" checksum="CEEE9E6C40BA9FE4" modified="2014-11-26" version="1">MARCLTGGTSPLCFASIAASGGSLLQSRRFHGHGGDRDKMVQVEFTLPDGENKMVVGYEGQTLLDVCAEQGLPMEGACGGSCACSTCHVYLEEKDMDLFQEPTDEENDMIDQAFYPEPTSRLGCQLKLKRCMHDGLKVRMPRATRNMYVDGAKVVPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SC73</accession>
    <name>A0A088SC73_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_261790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699998.1">
        <property type="nucleotide sequence ID" value="XM_010701696.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22576082"/>
    <dbReference type="KEGG" id="lpan:LPMP_261790"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260022400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_261790"/>
    <dbReference type="eggNOG" id="ENOG502RZXG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267537at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008507">
        <property type="entry name" value="DUF789"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05623">
        <property type="entry name" value="DUF789"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="603"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="658"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="791"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="893"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1028"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1062"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1112"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1206"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1354"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1531"/>
            <end position="1555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1567"/>
            <end position="1593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1869"/>
            <end position="1902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2077"/>
            <end position="2116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="451"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="675"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="689"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="724"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="921"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1123"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1206"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1399"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1531"/>
            <end position="1554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1568"/>
            <end position="1582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1875"/>
            <end position="1887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2286" mass="236742" checksum="835EF6578C1633C3" modified="2014-11-26" version="1">MYSSSRRQGGAAASVGARLTLPRSGANSAAMPAVYGGGEDVNGESLASNTGYSYNRYYGSDQANYFSSSTYGYNNNNQGEYPGGGGGSGGSTSMPYGSIPGPVVGSNSSGPGASDGQSMPVYSFPYHSSSSATANLQQCPNQHSTQYQQPQRQHQLQQHSPCSPQIPTVEQGGSAYQGYYQQTYQPQQPQMQLQQRSLHFQAASSTSQSTGGEGQYYGYCYGSSPGQRRSHARTASSSSGAHYYNPQQQQGCPPPSSYEGETLYNQGGTVQSSSQGGTTEGCYQQYAQCASYSYQSPSPSAQQQHSPYIGGEGQTFSISASYGYTLLGANKSSQPCSTTASAYGGESDVIQGASPALYSGGAYAQADSAGSTMNGSEVRVVGGHGYGASAATAAVGSGGSGVGCGSAIEGYYGTGYAGGCSAPVLHASPTQSVPYTDTGSDTVGMPLGPVSGKSGQAAASGSYPYPQQGNVADVEDGGQSYHGYAANGYRDYYYAAANQIGGCEISPGYGYTAGHTSSQQSPMSYQTSFGFGEAQPVSSATASPLIAENHHRGSGGPPLPQQPQYQRRGSFCALDPRYGGGGDGNGGSYDAYGYALQHPQQQGYYRGYSNPSQPQNRVDARSSGASLPVIRHSQCMQQQPETATRRYNAAEEQGKCGIAEQITKTQAPDDTVPMPSVRGRGPSRSSSSGGHGHGDGGVGGSVVPTPSRKRGKKGVGSGTAHAHSAADTEAAREAAENSEGREACGQRSATLSTTVLPASAKDAECQRQASLQQTDAPILEETLGAREPLVSLELPPSSVNAPRRQQPPLRHTGEGSTTGKSGGVPKGEVRSQQAADLCVPHKGGTDAATPDGGEYSMTGVKGNVDEEAKVDHASETFKDGSCGTATPAKAAIRMDHHSSSTASGGSCGQRRHSSSSTEFTAAHASPVSHGSGSGSGAQSFLRRSPLAPCLGAPFHTYICGAIVEQAAQLQANACSSSATGGRTGIDAASAGTPSVPLSTGSSQALPAMYTPVQRLLSREVSRGAHSVAAERKRRLAQASNDSGCGDEEGACAYGEEDVEYARDGAEAPEAASEGSKGEGAEGGLESVRDLGSMQSATTLLTADALAAVREAPNTPASLPPPGTTLTDNSLRSSGGRPHHMHLLAHHHSHHMRRSTPASEVSSPSAPALHHCRIYHSISPFLQPASLAASCTASLLAGGSAATNKYVQSPESASSTALPPRLPSGGGGGTPHLHRVGDGSREGSGAAATMQPQQLHMGSYPYQYNNQASIDLDGGRCAVVPEGGSGGAEELLHYSYQGNVSGGCNTTKPLLRQPPLQNPGTEDGTIDRCVGPGGALLTTSPATVVHSTFFNTLNQSSLPPSIGATARPGSSTPSPTSQHQHHHQRAANSGGASRFATSPDCASQQGGTSGPGNNMSSTYGSSHHVNSPAHHRYPSPTHPNGYFTGGSQINLQGGGHYPMLGTRPPYIYEYHVGQELLLEEFHAAMRFNAATFGNIACLVDAFSPQVPVASNLEFPCNEEQCQLICTRSSRGLSSPPGGDSSQHGSAPGSRSSPGGTFPVLLKEDARAIGGAGHNGTSGSGGAQEGPVLPAPRPAHADRTRYWDFSGFSYCEPVVTLKSIWQSFDNPFGCVVNLAEPIYPAPMRPAEGELVYTPLLSGFRIRFHPASSAYKRLAALREVRRQRHREEAAAGEGAGAATMDERAATSVEGAVRGGSSCHATGPYAEEDGVLKWSATDRPNNRNIIVEQIVELAKCDESYAELLTATTADVDHQSWVALMWQPVFCGGHSSKYSCGTFLAYYLLRAPRHLFIPFAYKSEGAAMNSSWSSPVFRGDRAALSFDLWSLQRHYHIARWVSPPPMTHIMATLSVDGEDDEADNTTSSCVSTSRGRNSWEEGQTGCASNRTTESFGFSTNGDSRVRLRDVYAGSASVGGGIDLHATTGTTNAATCPATAKTTYVRIPLVGLIPNRCRSEVWFKPMYDASLMGMRQHCGGGGGVMGGGDGAGAGVSGGGVGMGSSNGFGGAGSGGSGVGGNAGNSGDHAGLYAFYAPLFLIVTALQLMCWDAYNEWEHKSPTLTATAARPSTFSEARRDAEDPEVAVDGTAGAAGTPSSSFSNPLPAMMEETMSTAQRPQQQSDYDLEAATTAGTGGGNPTRGAVAHRRNLWPSYVTKGVELMTDAARQYRTVREVANLDAAVDESAGGSAMVGNNNGGFAAANEAGISSAEEKRPGEGDKSVAKQQRVGCAIVAGGTSSAMCDPVARVIAGLLDYYQWAQYDTSLTALATAYCAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SCX0</accession>
    <name>A0A088SCX0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dual specificity phosphatase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_271820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700268.1">
        <property type="nucleotide sequence ID" value="XM_010701966.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22576360"/>
    <dbReference type="KEGG" id="lpan:LPMP_271820"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270026400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_271820"/>
    <dbReference type="eggNOG" id="KOG1716">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="165342at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000130">
        <property type="entry name" value="Dual specificity protein phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46381:SF2">
        <property type="entry name" value="MAP KINASE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46381">
        <property type="entry name" value="MKPA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="663"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="727"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="940"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1111"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="415"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1137"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1175"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1205"/>
            <end position="1218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN99561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1432" mass="151371" checksum="B3DFA1E77E621731" modified="2014-11-26" version="1">MVANATTEWPRDMVQLFTPRGLAVPFSTDMTRPTLSSSSHGGAGHWHSPSVTPRTNGSTSGRLTPRSATAASAATLSSTLSATPTTPGNGCGVGGFLQASARSTPSLATPRASEFHFSVHLLTGKQADAIVAAAGLFTARAVEKLFLECAEFDRRLFYNLNVAKLKVMAGGYGMHPSPDVTSGRHSSGSGSNSTNAAARNPRKSPKASLSSRGGATTSTAITGNTTSRDVNNSNSAPSTSRQYRTAVLRASKELRRELLAVTRLSSVTVPVPCFNKRSSDHVTSTVVSSNPAELYSLNAVYRVLSGVRVGTPRWTHTGDVVSALNSAPYSVPGGASAGVAGGSSSGAAMLGATGPWYVDPLLSFRPPRRSVHGDGAAPSAATPSATMASIPSLNISSWLQRPQPLDVHRAARAAPAAMGPSGSAQPAATGATTPRMGRTPRRAWVPPSTPRTPSPPQLPSLALGVLSDDHRVGRVTPPGAALTSPTTLTLTASAAETHAFSLPLSLLCSATPGGAANVCSTKHSASAEQSITDASSLVSPAAALPPLQLLNVEASVKGEETVQRTSNPVPTADALSLPRGQEDGAQPDGCAAECCHHTRHYHHSHAGGGAQAMDGITGRYDIGAEGVSANRNGEASALPPVEDAEYNEVYVQQERAQRLKASQPVVTEVLPYLFVGGEDAARDRAQLLRKGITHVVNTVSCCCSNFYPDLFRYFTLSLSDAADEPIFSLFAVVNAFIENALERHQGRVFVHCQQGVSRSCTFIIAYIMWKKGLCYDRAYELVRARRNVCNPNLGFFMNLRLWEAQLSTPLLNSVFAYAPYTSTSPMPFCYQLTAYFDCATSSTVASAAASCSTLPLPVSSSCSPEGRLPGFLSPRDKEAHKQLRHDVLTRATDMSDAPQALPSTFSLDPRLAYLFLFAPGARAADRTSRSNSLCTDWRRAKEKGHQRPRLARSTNLGPGAGTCSDEDTSAVTGCVVMGPHCLNKVYTERALTACQQLLRFNFYNGEERTSLTNTGRVVHFHPMRPVRLLPTFSATCPPSTSSPFPPTTAAVPVEVVQQLLWTRVSSQLCIRMAQQSQWDALLSNTQLGAMLSYYIAEEDRLDSREAVRRNARERVTEGSGLHSSSSSSSRVAAGRPTSATGRTTLAPNFSLPVSPTALTSSLLRTGRRTPRTPRQLHTSSSGNSGYHRRGKESAKLASSDTAYWSSTGTSSSQRRSFSGSAPAVASTSVPQSAVSQLQHVTLLPIASSASAAAFPPHMESAGVSLPLQGISGLSLAAAAAHNENGPTHVAVRMAEGESFAYAYPFTASAKVTISDLDDLEDDQCYVLGFQQRTGTFVYLWRGTDAAESSTDVVSAFVRQLLSASDPAGQAAVAQALKAGEWTTCSLNFPRGDDGAAAASVADKADVATEVLAGVRVLYVEQGNEPKEFFTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SD02</accession>
    <name>A0A088SD02_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_272170</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700303.1">
        <property type="nucleotide sequence ID" value="XM_010702001.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22576395"/>
    <dbReference type="KEGG" id="lpan:LPMP_272170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270029900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_272170"/>
    <dbReference type="eggNOG" id="ENOG502QTIS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251741at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002190">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052993">
        <property type="entry name" value="CFA-57"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32215">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32215:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="607"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="912"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1009"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1454"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1211"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1274"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1392"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1460"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1485"/>
            <end position="1503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1514"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1533"/>
            <end position="1544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN99596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1590" mass="173123" checksum="8B950317AC2278F3" modified="2014-11-26" version="1">MDSRRALVKRYVFGTNHDGKSCLHWLDDGSLVYPVGKTVVLQQPNSCTQRFLEAAYQSSAITAIAMSANKKFMAIAEGGSHPQVQIIDTVTRKRRKVLSVTDLDSNKYVALSFSSDGRHLVTQGGAPGWNLHYWNWERSQPLASVSVRQLYSANVQVQGSKLSGASGGNATRIDSDSTRQEGDTQSLKAAASTVARSTLETSRTPPQVVTSIGICPLDPLLVTVAGIGFFRFYRYTEGLLQPQPSTGVPREQFDSFSTHLWVTEHNVVVATHSGGLLLIQDGRYLSAIEMPSLSPSELRGTVSDPLLEGVAVPAAVDVVTCIVPTNQQQHQQARHHSGFIAGTNHGNVLIFQGDGNATAAGGDVDGLGGEIAAGDATGYKFVCRLEVPAYEAGELQQQRLPHALQQASTGQNWAASALTTITDTTAAPLLGAATNTADAGSGGKRCTRRLFQLRDQVGTKGASAKVATAAAAGRRGQRGAADDISVYKSGVDSAGQALGGDAQRYSVSALALDQAEECLAVLMASGKLYGLNFKQDWPAREAMFHTSHISTTTPLFAGVVGGGEAPLLLPQLSSPLEHGGGGLGWASLAATPGHVSTRGVLFHPLYPFTHCGRVTGMDCSVRKPFLITSGSDHSIRIWSTQTGKLLMCQFFAQEPGAVAIHPDGLMAVICFPDKVRIMSVLWSSLRERRTINLRNASDVAFSKGGQLISIVHHNLVCIIDANTCELQGQLRGHLQRIKDFQWCSTTAYPTDNRVVTCSSDGMIMDWNMSEMRKQTEHTDKRFQYVAVASDDRSVWAVAAPTPATALDVSWKVLLREIDRQSLGTINVGTVKGGAAGGPGALGGAGAMAATSAGGGGVCSALGNSVGDYEFTETALTRLIVAPHQRVLVAGAEDGSVKAMTFPLQAGIQEAPIAAHALPVTRMALSFDERTLFTASADGSVIMWEVFAEKDTVKSTGAGATVLTAQHNDPASRRHTNGTEEVLVTRQEMEEQRVEIESLQQYIEKLKTDMESEDKRRAHEQGTRTRERSEELQQNAIALAAEYDALQRAKVDQEQTFLDSKNEKARDAAQTLENVEMQRQREVDTLADECGVLQHRLETAKVANAAELEALRASLAQTRAEDEAHFQDVLRQRTEAVRKLPHQLEQSQETNRVTLHQLELDTDSESQAVFQKLQATLQSLREGFLHLKGEGAVMRKSAVRLEREIEVRTNELQLLDGAKAALQSRLTDLTQQVAQLHQDIDERDSITEKKEKVIYNLKKHNQELEKHKYVLDHQIRELKGQIEPKQREIAELNVETKQQNANLEAQYTSNLTLRQNTEELKKDIAEQQRMLQARLRELQGLETYRSRAERDIGELAHQLQDPAALAAAVAQLYEVHVAPRDVKQIAPADPNVKNELQSQLEYLSTSVDALRRKLRSDQQRHKREVSAMMTENLSLIREIHSLRSEMDHLRARVAADTVSKQQQQYQLQRRTGGGGAGRARAERSGVADAGTTDTSDSAAADAVGRLIQFAPIESESTRSDTGMHRRGGDGGNSGQQPSIPQSEIEVNSRELRMLRAYIEKLERSLAGLPTSTAAAMASVRLPPVDPFATTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SFX0</accession>
    <name>A0A088SFX0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_310940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701482.1">
        <property type="nucleotide sequence ID" value="XM_010703180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SFX0"/>
    <dbReference type="GeneID" id="22577520"/>
    <dbReference type="KEGG" id="lpan:LPMP_310940"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310016000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_310940"/>
    <dbReference type="eggNOG" id="ENOG502S86C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265135at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="703"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="889"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="720"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="897"/>
            <end position="911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="935" mass="102100" checksum="F1BDE7D819BFDF81" modified="2014-11-26" version="1">MSFFSLLFGNDEKASQVKAVRVPSGGTNNTSPLAQVGGEGSRPNRAMLNTPTETASAIKRQCNGEPKRLQRHSATAPANRDRLSLWSRLLCRPEVYDPHVEAAPLTHLLDVEPADTQPQEHVAGCTDSGGASLQKCYSVRSSSGEGRCAATPLPEGDDENCNDSEDAVISGSVLSASIDVEEFEEAEVQSPSEESNTAELLLNPQVFHVFDTRRCRVRMSTVLSSPTSATNLRFTTTFPNDSGTLSMDTTESDAASSRGSVSSAERRLISPKELAKKHHQRRQQSKQAAKRAREYKEAWAALVASAQPHASGATDGEAAGQTDVRSAEGSGPPSIPPTCALGTSTVTSHLTNEALESLRESTQPVPYDLPVPFLARLCHYAPPPKKAKDGAEEENNRAESCCSRSSTDSSQVALDDELVNIETELPVMYGAVLRCRDSASRAREHDGKTSPSCTRLTTVTALRGSQRSPAGRYPLGSRAYVERVLFAQRRQQEWALFALLTEAHRQAREAHVRLAQLYYYYIIPILAQYRTEADVRGLERSLLMCGSGALRMYHTKFCRTVVYSRPMLQRSAHGDTSYSIACYFQVQPVDYQLVEYRFENTWRELFLEVKAYLGMQAREDASCSTLPTLSELENGASAVDGTTSTGPGSVCVAATMLHSMELFERQRHTHSAARDAEEWLTWYYYYFTPRVLSADSAEKRAAVQRSLLPPPPPPSSTRVSQREPRCGNDYSRTRASDSKAPQPALLESEYLPLSWIRACNTAEREKVLNYRRDLKLRVMKNFPTHRPVASGYGATARAVDSPGTVSETSSTLATAATSVKASRETVSANVAAASSGCQAVKHVSESRDLLNSAHETEGGWLLAEHVEADLKEAGLLKPSAEVLPEDAISRQSHDTAEVEDGNSEETDDEDGAIPTGTHCTVSAGCFGLSFFSIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SGE6</accession>
    <name>A0A088SGE6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nuclear segregation protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_320020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO00892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701692.1">
        <property type="nucleotide sequence ID" value="XM_010703390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SGE6"/>
    <dbReference type="GeneID" id="22577743"/>
    <dbReference type="KEGG" id="lpan:LPMP_320020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320005200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_320020"/>
    <dbReference type="eggNOG" id="ENOG502RIK9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273233at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042175">
        <property type="term" value="C:nuclear outer membrane-endoplasmic reticulum membrane network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039604">
        <property type="entry name" value="Bfr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027:SF2">
        <property type="entry name" value="LEBERCILIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027">
        <property type="entry name" value="NUCLEAR SEGREGATION PROTEIN BFR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="371"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="447"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="274"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="483" mass="55295" checksum="A389FD887BC53C3E" modified="2014-11-26" version="1">MLAEEEIAPVRPPAKKAPWQSMPGAPTRPDFAQYGPKLAALAEQRRGLIEQIKTLQRSVQEDAVTQSRNAERNAFMEELSGIDAIRKVQRDRRAAQDAEIAKLRKRRAEISDELRAVQAEVGGFTTIHEIDQAIDYMMRKMESSGGGLGAERRNQQRLHKLEDAKTHLQRLQPLTEAIKQMTEQEVILQQEYHAICEQIGILNKEYEEKLQQKRAMDKEAQSDGANRADVYRQCNKLRTQVSEIMHAMDSLRVERDKVSSEWDAWNKEARKKYFAQLEQQREQRRKEYEERRNAHKIEAKRARASQRQNPYSTEIDACSTLILYLKQKMMMARQDAEDRQRREAAAHFDPSVMAPAGCVLLNAGKWANNVPRSKTASKQQKQPQKPKEAPAPSNGNARFLQHPEGKIRLFQLINVEPELTLATIDDKIHHIEALMKKYEAHIQTGELVLSSGDDEEEEMDKISETSSKQAPEAAETTEEPATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SII3</accession>
    <name>A0A088SII3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter family-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_333390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702427.1">
        <property type="nucleotide sequence ID" value="XM_010704125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SII3"/>
    <dbReference type="GeneID" id="22578492"/>
    <dbReference type="KEGG" id="lpan:LPMP_333390"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330042300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_333390"/>
    <dbReference type="eggNOG" id="KOG0055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03228">
        <property type="entry name" value="ABCC_MRP_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003549">
        <property type="entry name" value="ABC transporter family-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="702"/>
            <end position="943"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO01627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="949" mass="103039" checksum="12BB3BDB994D6546" modified="2014-11-26" version="1">MGLADAPWFAIPLATATTVRVATTIVNFRNRRELQRRAGSKAARDAESLIGAVAHLAAHTEDCTYPSTENSTAAVIDLNTIPRRIVVSHARLRSLSCSLLPLFDCYAVACRCGTVPDAVKADVWNCLCAVVEAHIKAYVSASALSANISEASTALAVCELLAGRRYHVSRFLEPTRASSGLLLGSPPRHLLVEAVRKHRDECSTLRSLTLFVRLLHATCTLPEQLLLALLAIVNITYISRHVCSTSSETVPSALRYTVDVLNQATATGTAHYCTWRAFVRQVVTSSPGRMLASTTLGIVVSHLFTCAKEAASDAVLRHFHMTLKTDTVLALTRFDFVADTHWPLPGRVYSALAVVTNFSFADVDRLLDVVVERVQRWRTVWRIPVACAVGWLTRQGLDWLQRCWTRACLMTSFVACYGAGGRGCCAAPRERPGGSQRCPPPPPCRPHYGLQVLLLAAASPSGAIFSPSAVVQRLAEHTSWPLAPRPCLTATERVLQAVSTADGAAEVLRARYDAVRELCISPTEEAQAADSFAATLSLRRANGDGALGLSSWSPDLAVDVMILGGNLLEEVIDKALSTCNGVPIMAAVAATETPLRQPHDAPSPPPEDVVSAVYGVTRVADSGAVFVMPPARWWSPMSSFQFDVQTAQLRYHEHETYAQSMATLVHVQHTHQPTLDRQLWAHYNTPPSLLHLSGGTSAAWRVTFDHVFFRYPGTEHDVLHDVTFDVVAGGFLGIVGYSGAGKSTLLLLLSRVYAPTRGHIRINGYPIECMPPRALRRRLGHCWEGARGTCFLEGISVERNVAYGHLAAASVGAVTAALEQACVDTAVAARPNGLREPLRCSEWSGGEVARLMLARALMVPVDEAGIYMFDECTNALDSVTEAKVFSSHLYRRGNATRVIVSHRLASVRAADEILVLAHGRIVERGTWTQLLRGGDDSLFCTLYRAQTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4M0</accession>
    <name>A0AC62A4M0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Beta tubulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3320320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="XUY36740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="443" mass="49744" checksum="1E1DE6A6BC45CBBD" modified="2026-01-28" version="1">MREIVSCQAGQCGNQIGSKFWEVIADEHGVDPTGSYQGDSDLQLERMNVYFDESAGGRYVPRAVLMDLEPGTMDSVRAGPYGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELIDSVLDVCRKEAESCDCLQGFQLSHSLGGGTGSGMGTLLISKLREEYPDRIMMTFSVIPSPRVSDTVVEPYNTTLSVHQLVENSDESMCIDNEALYDICFRTLKLTTPTFGDLNHLVAAVMSGVTCCLRFPGQLNSDLRKLAVNLVPFPRLHFFMMGFAPLTSRGSQQYRGLSVAELTQQMFDAKNMMQAADPRHGRYLTASALFRGRMSTKEVDEQMLNVQNKNSSYFIEWIPNNIKSSICDIPPKGLKMSVTFIGNNTCIQEMFRRVGEQFTGMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATVEEEGEYDEEEEAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4Q1</accession>
    <name>A0AC62A4Q1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Beta tubulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3320360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="XUY36744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="443" mass="49744" checksum="1E1DE6A6BC45CBBD" modified="2026-01-28" version="1">MREIVSCQAGQCGNQIGSKFWEVIADEHGVDPTGSYQGDSDLQLERMNVYFDESAGGRYVPRAVLMDLEPGTMDSVRAGPYGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELIDSVLDVCRKEAESCDCLQGFQLSHSLGGGTGSGMGTLLISKLREEYPDRIMMTFSVIPSPRVSDTVVEPYNTTLSVHQLVENSDESMCIDNEALYDICFRTLKLTTPTFGDLNHLVAAVMSGVTCCLRFPGQLNSDLRKLAVNLVPFPRLHFFMMGFAPLTSRGSQQYRGLSVAELTQQMFDAKNMMQAADPRHGRYLTASALFRGRMSTKEVDEQMLNVQNKNSSYFIEWIPNNIKSSICDIPPKGLKMSVTFIGNNTCIQEMFRRVGEQFTGMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATVEEEGEYDEEEEAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4V1</accession>
    <name>A0AC62A4V1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3420670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="XUY36830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="171" mass="19444" checksum="6187D4B2C333D6AA" modified="2026-01-28" version="1">MSLFERPHRLTSVSSVVMGLNPATLREIDDYAMWMDEVHAELAGVYGEQAMQWKVSDITYATSDNPSRFSSRITQGLFESLHDYKALLEKIDAITTQLTEKTQLQELIETAISQDTEGGKSLRKQKRELRSLKANIIQLTRQGAELKYQLVCLSQQLSHVFKAKVVRISLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5S6</accession>
    <name>A0AC62A5S6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tuzin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2020020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="596" mass="65664" checksum="13F40C2DE73DC7E5" modified="2026-01-28" version="1">MLGPATRCCLLTAVRRSAFAQPGLEGLRIAAYAPAEPGVPPSPRRLPVAVGRVVAQLSPLVFAVDFRDSPPPPAVSLGSRVYVAYEREGAAPLPQQGGGVVDDAPGHGFLMGGFVVRVNPNGTLGVLLENNRVDLGVPPERIAVTEGVCKFVRHPGYLQVAEWVRSAGLSGADEVEGTACMLYHRGWRAERLHLLEAPDTHCMAHLSQRSRMSLMEKAEWQRDHHRQMRSLSSERVKERDRRYMAAKYAGILSASVAFCGALSLFGWNYRNHLTHQRTSQMRFAVRTLCRKAPPGASTTADAAHQLSRQTRREALERWIRPVFEQLDTAHPRIVVITGSFGCGKSSLCRAAMREDGMVGVVVDVRLREHPLRRVVMALGVPHVEACGDALDFISEACCRAKSMMGGKTPVSVLGLREAGSLARVYNEALALACERRVCHVVVELPLEALTVTSTLLPRLDFYTVPNFSRSQAHEYIQHRLDALDTEAFLDTVGTSRADLDELLAAAHQRRVSPAEYTSERLLRAMRQLQAAWGDDAQLKTAVKRLAQRPYGEDRHVGLDGSSLSHSSLRDVVLYNPVQDAWHFRSRVLHTAAACLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A676</accession>
    <name>A0AC62A676_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amastin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2020330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="218" mass="24213" checksum="9EFD9E76712432A0" modified="2026-01-28" version="1">MEWNIPILLYAIVQVIAFVLVLFGTPIDMYRFRPRYIRPNATVTTLWGVKKGAFNSTNLMTSDYLWRRCTGRRDRFRLAQAFAVISIFVYGAAAALGFIMLYCCSFFRMVCLALNIVGAVTLCIVWAAVAVTYHTYEGPDCWQESVFSTYGAGFVLLLLAWLLDLFNIVVLLLPISIAAGGAGGSSSKDSKKQDESSNDHSRESSMEGSRQNDLSEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RH99</accession>
    <name>A0A088RH99_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Adenosine monophosphate deaminase, putative</fullName>
            <ecNumber evidence="4">3.5.4.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_040250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.6" evidence="4"/>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="AIN95352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703674.1">
        <property type="nucleotide sequence ID" value="XM_010705372.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22571984"/>
    <dbReference type="KEGG" id="lpan:LPMP_040250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040008300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_040250"/>
    <dbReference type="eggNOG" id="KOG1096">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1723809at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003876">
        <property type="term" value="F:AMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000035">
        <property type="entry name" value="Probable amp deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.20:FF:000003">
        <property type="entry name" value="Putative adenosine monophosphate deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006329">
        <property type="entry name" value="AMPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359:SF5">
        <property type="entry name" value="MONOPHOSPHATE DEAMINASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19326">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="221"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1094"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1693"/>
            <end position="1724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1796"/>
            <end position="1832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1895"/>
            <end position="1941"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1733"/>
            <end position="1774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1707"/>
            <end position="1722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1796"/>
            <end position="1817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1818"/>
            <end position="1832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1913"/>
            <end position="1922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1923"/>
            <end position="1941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN95352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1941" mass="210209" checksum="5D750CD4A41FE485" modified="2014-11-26" version="1">MSAQSTDEAISLASISSYPGRQRSTSTAYAEDRAVNKNGGSGDPAAAFHGTSRVPSAPGGTGATAANGPSMSCRGRFSSSLFNSTSGGSVPIAAVSSNTGVGSGVSTQSRVRPTSLQYRQPSSVMWGELAAARGGTSAVGSAGNSNNTSAVTNVYTLQLPGDDGGVEMAAAQPRLLGALRMRETYKDVDKGHCELNGGGSSSSNGNGGVNRLASVSVFAAEASRPTQPVQGAPHPAQPTPPQQQQQQVLPQPPMTGPTTLQQVDGVFFWSDEKTPIASLAQFRADVLTLAACVQHPSCVAASRYRLEVLEEKYHLHRLYNTDVEENTDRYRRGGGLFANACRVDTCVGASTAMNAQSLVEYIQRTIDEHGNDVVGVSDDTPWGIGLVTTGTGSGVGAPNGEQLTLARVCELLGLPDPYLLTVEGLGLQPSVNRALPYYNALDPSMNGSGRNSAALLRLFLSIGEHSQRGTYLAGAIQPYLTRNELRTGGVQATEMTLEITGALAQEWENTATWVRTHELDSFCTNQFQLAFPVTKWCSRGGAAANRAPSLSFGMHTGRADGDEPRDDRSITGNDMHGVGHCLSGSGAGGNAVSAAALPSGASPDEVLNYDNYQQLLDHIFLPLFMATLAPEDPKYVDLAALLQRTGALLLTGNENADVMGSTAAGDGGRKRASGGGADGGVAAVDATALHGDAMSTGWRRRPADTPYTEPVSLTYLCYYIWANLCSLNALRRRRGQNVLQLRVVASSATMPNTSSAHDASLLLLSYLIADVVVDAVALDRQPVLQYLYGLHQIGVAMCPIARSSLGTTSLDEHPVARLLWRGLCVSLCTLNPLYYHSSQDPLLEEYTTAAKVHRLSPTDISEMTLHSVCMSSFEEEVKAVWLGTGFLRDGWRANAVELTSVPTARLQLRHESWTAERKLLLLSPGSPTGLMIGAAVPVAEAGPRLEDAQSGARRDVRTAPNRFTAVLSPGRSAVTTPAPSTQPGIVSAGGAAGALQSQAPYAVLDPAVDFPRAALIGPFDRDIQNAHLVQALHRALDLRHQYSSLPLPPQPSRSTVVATGDGVVSTDVKAGWLAALTHDPQTVLPHPTQSMSWAFKKSASSPHDKGVGGGHAPNATGASSYLQFDEDEWKYKTVEGIIVPHEVHQIPRLPQDMYHYTEFCNHVEEIRRLIDHIHVRDFALRRLQLLEHRFKLHAAVNHSRELGSTAARASHNRDFYQSTKVDNNIRMETGMTARQLLAFIVDKATHNGDDIVSHPQGKEPQTLRQLLSELHITADSLTVDDLNVQAGATSSDGGAPQNPFAPEGQRQDELLTLLLKTDNQMNGRYFAELTKRTFEELSRDRHTFTESRLPVYGASAEEWALLSHWFDTHGMSSSHNQWVVQVPRIYSSLRTAGRVASFAEYLEHIFEPLWRISLHPHSDPRLFHFVNHIAAFDCVEDERRPEVPLHLAMRAPHAWTSEEEPPYNYYLYHLYANLRSLNHFRQRRRFSIFSFRPSCGEAGSIDHLIGGFLLAQGINYGVRLADSAPLQYLFYLAQVGVTLSPLSNNTKLDLNYLHNPFPEFFRRGLRVSLGTDSPLLYHHTQEPLLEEYSIASKVWKLSPSDLSEVARNSVLLSNFSVKFKEEKLGPLHFLSSSAGNDTAKTHLPDVRVAYRFEAYHTEVGFLEYISGQHFHRAMLTLEMEAQCRQLCGVSTGNGSGTSAGEHDRGARATPATGSSGSSDAAGLIDTTPKEEDLLQLEAQRTRMQWQLQELTGAVNDLHRQNRLLTTKLAEEKERDQMAAQLRRQRVSDTLRERQGLATQQKVHATRNGSPSVPHQLTPSAASSSQSQSPLSSELLRVDAEAANVSPAAVAAHLALPLPPSTLHASGDSAFSAVRNRKQQQGGAVAQTRRLLARTESLWRTTSVQEEGGGKDMQPPPQLPPLEVPTSSTSQPSVSPVPLCKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHI6</accession>
    <name>A0A088RHI6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin-conjugating enzyme E2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_020300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009371">
        <property type="protein sequence ID" value="AIN95210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698175.1">
        <property type="nucleotide sequence ID" value="XM_010699873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHI6"/>
    <dbReference type="GeneID" id="22571840"/>
    <dbReference type="KEGG" id="lpan:LPMP_020300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000015000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_020300"/>
    <dbReference type="eggNOG" id="KOG0424">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6600758at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23798">
        <property type="entry name" value="UBCc_UBE2I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="73"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN95210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="223" mass="24662" checksum="2AE7212B62BA32B3" modified="2014-11-26" version="1">MPGLSLAQSRLREERKAWRRDRPFGFWAKPLEIVPGSCRLSGVKHMREGTQLTLPTASGTVASNTAASSSSVSISSSSATSGASAAESLTSAAAATPAGLDLLHWEAGIPGKPGTPWEGGEFRLRLSFTEDYPTKPPKCVFTPVLFHPNVYPSGTVCLSILNEEKDWRPNITIKQILLAIQELLNHPNLKDPAQEEPYRVYMRDVKEYEARVREEVRKHHWKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHY8</accession>
    <name>A0A088RHY8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L10, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_040710</name>
        <name evidence="5" type="ORF">LPMP_040900</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="AIN95395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="AIN95413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703717.1">
        <property type="nucleotide sequence ID" value="XM_010705415.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703735.1">
        <property type="nucleotide sequence ID" value="XM_010705433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHY8"/>
    <dbReference type="GeneID" id="22572030"/>
    <dbReference type="GeneID" id="22572049"/>
    <dbReference type="KEGG" id="lpan:LPMP_040710"/>
    <dbReference type="KEGG" id="lpan:LPMP_040900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040015800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_040710"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_040900"/>
    <dbReference type="eggNOG" id="KOG0857">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268456at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018255">
        <property type="entry name" value="Ribosomal_uL16_CS_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001197">
        <property type="entry name" value="Ribosomal_uL16_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003239">
        <property type="entry name" value="PRK04199.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00279">
        <property type="entry name" value="uL16_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11726">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005590">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01257">
        <property type="entry name" value="RIBOSOMAL_L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN95395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN95413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="213" mass="24613" checksum="22EB5FD2FC9B3725" modified="2014-11-26" version="1">MARRPSRCYRFCKNKPYPKSRFCRGVPDPKIRNFDIGRRRATVDEFPVCIHVVSRELEQIASEALEAARIQANKYMVKRANKDVFHMRIRAHPFHVLRINKMLSCAGADRLQTGMRGAFGKPNGVCARVRIGQILLSMRTKEAYVPQAYEALRRAKMKFPGRQIIVTSKYWGFTNILRTEYEALRDAGKLEQRGIHCKMIVPKGKITMRNVMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIL3</accession>
    <name>A0A088RIL3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_060710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703952.1">
        <property type="nucleotide sequence ID" value="XM_010705650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIL3"/>
    <dbReference type="GeneID" id="22572277"/>
    <dbReference type="KEGG" id="lpan:LPMP_060710"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060013100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_060710"/>
    <dbReference type="eggNOG" id="ENOG502SHN5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267167at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="610"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="946" mass="101165" checksum="C6FED3D73358E9D3" modified="2014-11-26" version="1">MMLSSSSSSSSGRWRSSHSQLVSQQPLRPYHQREQQSQEMLQGNAHFASLLQRPREGPPQPQEVTHTTVPGPLIAPALPARQQQQLPVPRPSSCATPATFSPRAFVQVQPQLQRGCEDVQHQRVPAGGTSATVASVGGGDGLDDSSSPAPSTANMAEWWSRDGSLLSHQDESDSTSCDGTYQLATTSSTMTDQRSASPKQAAPVELGDDATCLSDLRRRVAAQIEKCGPRRPAGPGAAAASTALVSQSLSTSSCGCPTSCTCRSDTPDGDVFGVSADAHRRARRASHARPARQPHTPSTAARRDAYPSCKARGTQYMTYCSDASSETGTTPVQWSSDKDSDSLCSSCCRCHCDCSLSFRERRHAQHEDIEFPPKLSTASSTEGSRGRGDDASLCSLCRGAAHAGAMRRRGTAASFTHQDDPCRDALRGGRLSAEAPLLLRLSTSGASRVPMGGSAGYAATRVELEQADRRLACLQGAPALLGDAAGERRGAYDGVTAAVRQPDRCTGSAQTEAVTATAPTASQSEEQRCRHDEKEAAEWKSLAAAHCAEVALPLLQGELASFEARTAVQQQAHLDVVAAQMRAFHDEVRQRTRELMDLQLQYQRQLEQQHMTQQEEAEAAGRTAARVDCATSPMETSRAAAAGEPTLKAAPPSVPLQRDVGTQHSDGALELLAAVRTEAASWVAQQLLFMEAERRDSVAQDEAESRDRLLNVVEGPCRSQLLLCQAQLLHWQQECAAVRQRTFLAADLHALELRERLARQELTGESSLAQHELFESFEKQRCQAAEEAVHSQVKLLKDELTNVQSKLKMVEAEHADTLEHARQLRLQLVHALRMPTVTLVDRSAVSTATCGAGDAAIAAAAYAYATAAAGTEHGGAVGILGDTSQGGTDITSNAHAASSTGLDTGAVGWHTLLSGIDGGLDLPVHRRFAHAHQEALRVTRAQSRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIY4</accession>
    <name>A0A088RIY4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Band 7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_010080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009370">
        <property type="protein sequence ID" value="AIN95109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696651.1">
        <property type="nucleotide sequence ID" value="XM_010698349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIY4"/>
    <dbReference type="GeneID" id="22571737"/>
    <dbReference type="KEGG" id="lpan:LPMP_010080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000031500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_010080"/>
    <dbReference type="eggNOG" id="ENOG502S371">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="244029at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN95109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="25085" checksum="00025971FFB6AF47" modified="2014-11-26" version="1">MPIAPPTKERPSSSGGVLLPLAAVGAGLLCLWKAIQICSVPVHPRCVTVVYDTRRKTVLCTSADREMHRESLPRVSHFGVSLYFGSAMMYWSRTWLLVPPSSFFGVFTLPRGVFEEPGESVNCVVEEVAVRDGSVNIMATVFYTISFDQMERYLAAIGPEPPNEVIGKAVAHVARVRCAEQSAGILLSKTRREATFMGPYKDHLTSKLMSEAAVLVNDVVVESVVLLEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIY8</accession>
    <name>A0A088RIY8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_010130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009370">
        <property type="protein sequence ID" value="AIN95114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696656.1">
        <property type="nucleotide sequence ID" value="XM_010698354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIY8"/>
    <dbReference type="GeneID" id="22571742"/>
    <dbReference type="KEGG" id="lpan:LPMP_010130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000048800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_010130"/>
    <dbReference type="eggNOG" id="ENOG502S66B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264387at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="364" mass="39921" checksum="17FD266E6AEB70D7" modified="2014-11-26" version="1">MVLAQPSSGALHSVQGGIGDASCADWRGQVVRYVNGAFTPPLLTEEVVQSSVDTFEDAAWVRDEAVRSYAEFHNNVESLHATMRTQLRPVWRTAMQLHPDILADVRDEWHLRRRDSIPDNIPISVAASQGIELQETILHDVEDALQVLRNTSVRFAAHFLSDKEKISMGANPAYLRAPDIDREVVMSRSQSISTSPQRTLPAMTASILSSPGGAGSGHVRHSTSSASVALHTPSRQHSGRRHSRYGHHHHRHYSDVAGLVSSNSNRRTDSCKSSRRSRGTGDDPLLEELRKQYQVRISELKARNEDEGERRRGRHGASTSARAAPPRHASWAHAAVPRSSSLSLTASSTSSSALTGTSSTRSRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJ01</accession>
    <name>A0A088RJ01_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_010230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009370">
        <property type="protein sequence ID" value="AIN95124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696666.1">
        <property type="nucleotide sequence ID" value="XM_010698364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJ01"/>
    <dbReference type="GeneID" id="22571752"/>
    <dbReference type="KEGG" id="lpan:LPMP_010230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_010006700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_010230"/>
    <dbReference type="eggNOG" id="ENOG502SMW9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266876at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN95124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="138" mass="14975" checksum="C96FBC28761D22F1" modified="2014-11-26" version="1">MYRTAPQILFQFVGGLSITQYAYPVLYDAFTAEKSDPHAATVAMPSNSGSFSGLWGSVRWSFRAPPVDRALSDDVAELLRTHYWFASAVLLLAVVSGGAPSLLGSGLSVYCNGGPEGKARYSRLKQQLRNFSEKGNHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJ43</accession>
    <name>A0A088RJ43_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATG8/AUT7/APG8/PAZ2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ATG8C.3</name>
        <name evidence="6" type="ORF">LPMP_090170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN95933.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704255.1">
        <property type="nucleotide sequence ID" value="XM_010705953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJ43"/>
    <dbReference type="GeneID" id="22572587"/>
    <dbReference type="KEGG" id="lpan:LPMP_090170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090006600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_090170"/>
    <dbReference type="eggNOG" id="ENOG502SPH2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="260833at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000221">
        <property type="entry name" value="Autophagy-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004241">
        <property type="entry name" value="Atg8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02991">
        <property type="entry name" value="ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604241-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN95933.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="124" mass="12747" checksum="547644016555283B" modified="2026-01-28" version="2">MSAYVSSTPLEARVARCASLRATNAVPVVVEEAQARGGKAHFSALPRETTAAQLVAAVRAFRGVAANKPVTLTVAGCSVSPSATLGELHDACKQADDGMLYVAYTAERSMGAAVCTPCASCSWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJB0</accession>
    <name>A0A088RJB0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Voltage-dependent anion-selective channel, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_020340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009371">
        <property type="protein sequence ID" value="AIN95214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698179.1">
        <property type="nucleotide sequence ID" value="XM_010699877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJB0"/>
    <dbReference type="GeneID" id="22571844"/>
    <dbReference type="KEGG" id="lpan:LPMP_020340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_020008400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_020340"/>
    <dbReference type="eggNOG" id="ENOG502RZ39">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269709at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN95214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="292" mass="32010" checksum="DAD7EE2C6F687580" modified="2014-11-26" version="1">MSREKSCFTGSTGKVYSTPSLFKDYNKSTNDLLNKNFPAANTWVLECKYKGPKDTFFINPQVNSSGKMLADIEYVAACNGGLKVTLTPDIMRELKGTAHYTLHGHKVEVMVQRLQNKCHYEISHETCVALSKLASINEKITPEHVELGMGIDVAPNCQVGCGAVYNICANDCNWNLGCRYADKGFEVALRTNRFKTYHTSASFPCSFMLCGNKCVVRAAVEVVCGCGCGDKGTAVTAGIESTCPVLPANTIKARMNRNMNWVVSYIAKMADNWAVCLSLDENLKVGVQLTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJS4</accession>
    <name>A0A088RJS4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Optic atrophy 3 protein-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_110360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPA3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696885.1">
        <property type="nucleotide sequence ID" value="XM_010698583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJS4"/>
    <dbReference type="GeneID" id="22572901"/>
    <dbReference type="KEGG" id="lpan:LPMP_110360"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_110006000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_110360"/>
    <dbReference type="eggNOG" id="ENOG502S55P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2129069at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019216">
        <property type="term" value="P:regulation of lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010754">
        <property type="entry name" value="OPA3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499:SF0">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07047">
        <property type="entry name" value="OPA3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN96232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="400" mass="42513" checksum="7D5F5F8E43FB4216" modified="2014-11-26" version="1">MVALPAFKFVFLAIRQVSRPVAKKIVSRATTKQALTYGVCIGLGRISLGLSGVISEWTRAEEQKQKEARRRLEEDNAKAAQAVNANAATNVAGATMDMMGKASTTARGSEAIATAGSSRGTTSAVSSSAKAQATGAAETHAAATAKSAATPATVIPRSRSLLQSIVYGPQPKGGVVDTYDSTIFLDASRTVGEAARVFIRYPSRSAWDVFRKTFLAPFPEERLVAAGADLLIELVAYTVLCTLLVVELYQQSRISAAKEAHMQARLGAIESKVNELVEYSNSTTLFPPVRELPPVRELRVTGRLNALWGAVAGGASFVGSALSGNSDGSDKGGESLVAQERGRLAQSGKAVVPQRKNGSNVVYAPPRDPTVKVSKHDETILLQEELDQLMRNVTQAEKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RK14</accession>
    <name>A0A088RK14_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_120240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009381">
        <property type="protein sequence ID" value="AIN96352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697005.1">
        <property type="nucleotide sequence ID" value="XM_010698703.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22573030"/>
    <dbReference type="KEGG" id="lpan:LPMP_120240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_120007200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_120240"/>
    <dbReference type="eggNOG" id="ENOG502S7IV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273908at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="907"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1256"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1336"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="920"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1262"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1336"/>
            <end position="1348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1577" mass="166091" checksum="4B7BFC63070115AA" modified="2014-11-26" version="1">MSASSNLEKLLPSLYEFLSVHPSDAYASASAAPTQRSGDDLYPGCSSDNGRSNATSPSAISSSSLGSDLACATPAIIVQSYTRWRRCITVWRRVIGNDSLFLTVLLHAGCLWCPNYAALYRAKRDITTRAQQQRRSAQATPASEDKFTLEVGSATLEGEQGGLVLRPWTAATSDTPHNSPVKRRSKRGGKVAAEAAAHSISVLAAAVDVHAELAAMCPASVWALHVLHFLRVEEVCTVPCCGSKAKSVRHGNLTRTNSETSSYASWSPHGDSGDSSENEFSSTSSNSRTSRSGSRDSHSSIENARANSDRTSDAVDGCIASGRKPAAGRGWGGGRRRGGRGDGGGSGQRGMKRQNRPERAERHLASSTSGDRTRRRRRDGERACEGRLPFDASWTKWAASSSLLPKLSKNEGDGGGGGDKHLRSTLAAVLSVLQQQEQQRVSARLRDGTVDGDVGETNDKTPHGKGEGFGAGYRTCDCGNSTLNGTSATAEQKHALLLRATITLVSEEEPLVQQVATALVDEWLDLMSVETSTPQSRVTTTSAPTEVMGEVTTLSDGSAPRRRSGLPRTQSSPCADASVQALHHHRLCDARNYWLSCLLKMVAYLDGVHSALREENIHMSAVLARQGIAPQDAEDIFTKSLPAIFNCVLVEEALHSAATALPASQPRTFTTWATSPLLASACGSPALRLWMPPPALLLPFHLIGRGSVFGVWVPPGVAARRGSIDYLPALASTRTSTRAHGRFVSYVIDSHGLHLGTEPYCRCGALVPESKSVDKERRGGVEALQSCKRASVGVNAQDMTAHPRPPRHSLGHCRLGFAVRCAEPESLLGTHYLTSLEYLLPVLRVPDVKSQQAANGDLPRDQLEQQPALRWWTCTLNETVGTPRMDVYASRTLLMLPIPTQNTLDSTAGHAASSARVDAGTTTNTLTVGGTHHAETRAKSGPSALASSSATVGARKRPRGGFHRGPTVSAEEQAVRRQHPLLYHAMRLQLRAGKFAYKGGSGGSESGDTELVLLYGHPRGEETTTLRHMGFTVRTGSHHRLGRGGAAFARRMDLPAGSSVTELNSGVGGGRGRLTLSRDALGTTLEGMYLIARRVLGLQGLFVSSASALTTPAAAAAEARTSGKGSPSVTGAAALGDGDACASLNGTTVTHMAASTLGPQTEKEALGTVAATLALMCLVLSHSLLDDLLEQPFLVLWTTELASFVLDVSLLMPRPLPRLLKADGFALALLPQPAQSLLLMVGLAATLVTREAHMAAASNQGSEGGDGSSGGRGRGAGGTSSTSTSTIPQSHPWWFTFRSTVLRDTELPSCLYSGVWPIVEKAEATLATLLAEARRDTSGNRQASDGRHSHPSLPVGSDGGEEYAGAGAPMHVSGRGGAGGRRVLSLSAPSPPTAAGRQPPVDALGTSSSKNRDVTPHGSTIDRANPYGHRLLLKESRAGGAPGELSVKATLNRNSNAAACGAGSVVSADQSYVPRRLCGHAVLCQDDGTWSAEAGSSDTHAASRALPFAEGVRVVSGIEVALLRTSLAHVEVVSPLSRMFSLSLSGVTLLPQLTAAFASALWVSLEAEEMYSGTSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKG5</accession>
    <name>A0A088RKG5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_130880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697170.1">
        <property type="nucleotide sequence ID" value="XM_010698868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKG5"/>
    <dbReference type="GeneID" id="22573198"/>
    <dbReference type="KEGG" id="lpan:LPMP_130880"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130013100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_130880"/>
    <dbReference type="eggNOG" id="ENOG502RZWC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273469at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="501" mass="54764" checksum="074AADD3A8BF5781" modified="2014-11-26" version="1">MARRDRVPRHKSHTHKRNKNAKLSPFQREQKRAKMANQVPTVTTIGSLDSIPHSQRHIFAYLQEKRSRQEARRAALEKARQEQDARVPPTTATSGGSSSSSSSSRGSGRTSEKEKQEAAEASSATIPAAAVSATPAASTSKKLSKRVEYASLNDELSASVGAVLQSPSSRHGGLTAASGGDSTGGEPRSVEEVIARKKERKHRRKQASRRARIASQLQEMEEALGKYAKTANGSGKQRRTKNGRGSDGTQVETADDVRERVNLAFERKLRAMKREAEDATFQRDAAEAAATGAHRQGGDGKARKRRRETPSAAGEHANGRDNGNGLDETAPQRQRKRISFNPDVEGRAAEAAGANRIEKRSAARKPRDFCELVDVVRYGERVEAPPVFDVVPNHNAAVSRWTNAPVRAEGRRGHGSDGATERHRLLAGGSPLAQQKRLACLGLAPAITHATRADGTAARMNKEEQIKALRDRVMATYQCRRRKEVAERKGVDMKHKFPQFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKJ3</accession>
    <name>A0A088RKJ3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">DNA/RNA non-specific endonuclease-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_131140</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA/RNA non-specific endonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697195.1">
        <property type="nucleotide sequence ID" value="XM_010698893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKJ3"/>
    <dbReference type="GeneID" id="22573224"/>
    <dbReference type="KEGG" id="lpan:LPMP_131140"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130016200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_131140"/>
    <dbReference type="eggNOG" id="ENOG502SAWV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266836at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018524">
        <property type="entry name" value="DNA/RNA_endonuclease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="Endo_G_ENPP1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020821">
        <property type="entry name" value="ENPP1-3/EXOG-like_nuc-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040255">
        <property type="entry name" value="Non-specific_endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966:SF5">
        <property type="entry name" value="ENDONUCLEASE G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966">
        <property type="entry name" value="ENDONUCLEASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00892">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00477">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01070">
        <property type="entry name" value="NUCLEASE_NON_SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase" evidence="12">
        <location>
            <begin position="376"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="ENPP1-3/EXOG-like endonuclease/phosphodiesterase" evidence="11">
        <location>
            <begin position="377"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="499"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="698"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="773"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="510"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="521"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="704"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="717"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="773"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="441"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIN96542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="888" mass="96859" checksum="FCBECAEEDCF73CF8" modified="2014-11-26" version="1">MLLRPDAITYAGSLSPSPHTHTLSALFHCCFPPALLSLSHIGLLLSLGAGGGCLDRRLHRSSLMEKRPTRPAVVPLSTSDPPRDCAAPESSLPSALFSLPSWCTRATQRLLHEHAYYAAAQLHVARAGPTAPPSLSTSASALETPSTPSRSAKLWLTCATAGVAGTCGVIVGVRLSPWLSRRATRLYSQREAKYRNPLRLLPSPAAVARPESWGWRSLWHPLAPPRGLEHQASTDARRPDYGHPAEWLAACIGYRWLPWRISQPTLLKLYSSVRHSQQSSTDRDTDKEVRWGTRMINKGAHTLTKHSTVAAATKPTTTSLIPSVLLFIVRLARAPLQKWQPRPQHLVDVFVSATCQSTEKPPSTSAAAAPPLLCLPRQGFALLYDPVARLSVWCGYYVTRDTVDRARRQSRCLTFFTDRSLEKTVRRVPAEMKARGYDRGHLAPHASVAASAQAAIEAALLSNVQLQHHQINRGVWRWLEAATRAYVRQLPLALTPRDLARQQQSVRNKTATGAAGGETASPSDAASFTQAGPTSLAPHCGSSVTPCCGRPPKSASSVPASSISCTHTRGQAAKRINPGGPRQVLLRDSELIARLLAAPGVGSGAAPHLRLHRGAVWGCAARTLRYCWAGQWRWWWRHCSGRALSRHCEREVAVNVGPLYYKQRNDVGQGDRQCCGTTALSTPATTAISPTAISLSRHCGSGSRKVHQRRRRGDRVSPPTWSSSPSPQSLFIPDAFFFSLWDVHTHEHVHLIVPNRPDAASIQAVTAAVAARRSRAAAGPTASKPLPSQRRRHNATPPSQLPSEEDLETTLRSLVVPTVKLERLFAESLVELRSRCRSASGMDVASRNTTSKVEHAASSVALRTSFSLFPVYRQRWLWRQGGSGSGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKK4</accession>
    <name>A0A088RKK4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">deoxyribose-phosphate aldolase</fullName>
            <ecNumber evidence="2">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_061050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="2"/>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703986.1">
        <property type="nucleotide sequence ID" value="XM_010705684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKK4"/>
    <dbReference type="GeneID" id="22572311"/>
    <dbReference type="KEGG" id="lpan:LPMP_061050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060016700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_061050"/>
    <dbReference type="eggNOG" id="KOG3981">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="70823at2759"/>
    <dbReference type="UniPathway" id="UPA00002">
        <property type="reaction ID" value="UER00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046386">
        <property type="term" value="P:deoxyribose phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000044">
        <property type="entry name" value="Deoxyribose-phosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00114">
        <property type="entry name" value="DeoC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028581">
        <property type="entry name" value="DeoC_typeI"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="DEOXYRIBOSE-PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889:SF1">
        <property type="entry name" value="DEOXYRIBOSE-PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN95664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="281" mass="29802" checksum="F3BD911A6937813B" modified="2014-11-26" version="1">MHDQQPIAKVNFDMPSRPGHKGELNDKILQRVRFIAAQLDLPRLEEKFAHLKETNGTWRTGSASDSIDLARYIDHTLLKADASHAAIVQLCEEAKAHHFKAVCVNGCHVAQCARLLAGSEVQVACVCGFPLGQMTSAMKVAEATEEISNGAQEVDMVINIGALKSKCYDDVFTDIKGVCDVCARANAVSKVILETCLLSEEEIVDACIMSVAAGATFVKTSTGFSTGGATPEAVDIMLAVVGNEASVKASGGVRDHNAVMQYVQAGVKRIGTSSGVVIVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKU4</accession>
    <name>A0A088RKU4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_131250</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697206.1">
        <property type="nucleotide sequence ID" value="XM_010698904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKU4"/>
    <dbReference type="GeneID" id="22573235"/>
    <dbReference type="KEGG" id="lpan:LPMP_131250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130017300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_131250"/>
    <dbReference type="eggNOG" id="KOG1277">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1666796at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF41">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007353567" description="Transmembrane 9 superfamily member" evidence="7">
        <location>
            <begin position="22"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="481"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="519"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="551"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN96553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="589" mass="66560" checksum="9C35FC4DA40835CD" modified="2014-11-26" version="1">MSPYWFLTVVALAYVVCVSTARELTHAYLDGDEVNIFVDKMAPRDNPYETYDYIEAPGCTLQKDAKPLTFGELLAGHQAYTLPTNIRFNHNTGTAVLCKYKTNVRETALLIEMIRGDYRYELVIDELPVRSAIGEETGENKFSIFLHRTFHIGVNGNRIVSATLETSSPAKLEADTIYTFTYSVVFQASSVEYANRLSTVLDTRYVSSRTRFVSLINSSLIALFLFSVITLIFSRTLRHERAKLERETQFRFEGQDIIDESGWRCLYADVFRVPRHTGTFCAILGCGTQLLVLSAVTILLSVMSNYRISMNHNLVTYTVFGYVFTSGIAGYVSGYQFIGCSFLAPPMASKWIRAFHVAFFLVPMIYVTAFLPSSTVALLYGSSQLPYLKGVLILLCLWVFVAYPLCLAGVLCSRYVFRRTERRRNIPHVNQISRLIPRPPRRLLAPQCLLLVSGIPPFISVFVEFSFVFTSIWTFKVFHLYGFLTITALLYIAISACVSIIATFLLLSTENHHWKWMSMGFGASCSMYAFGYAVFFYLFKASMHGLFMFVVYYSYCIALMLCLALIGGTVAYFAASCFVKVLYGQAKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RL45</accession>
    <name>A0A088RL45_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_150020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697380.1">
        <property type="nucleotide sequence ID" value="XM_010699078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RL45"/>
    <dbReference type="GeneID" id="22573418"/>
    <dbReference type="KEGG" id="lpan:LPMP_150020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150005100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_150020"/>
    <dbReference type="OrthoDB" id="259315at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36587">
        <property type="entry name" value="EXPRESSION SITE-ASSOCIATED GENE 3 (ESAG3)-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36587:SF2">
        <property type="entry name" value="EXPRESSION SITE-ASSOCIATED GENE 3 (ESAG3)-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839024" evidence="1">
        <location>
            <begin position="23"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="574" mass="65632" checksum="C75D8D36356EE2FB" modified="2014-11-26" version="1">MRRFKRFLLSTLILALVLPVISAPAVFWGLSASHCHYLFHPIEPVERAALGQREPLPHRSTDKRPDSNADLQASINAYLAQHNNTEGVQLPPVRIHFIAASNQTDWSFCMATASCALSGVELSVLGTETTYSHVWRFEQYLDYLDRAGVRDEDIVVTLDTDVAWTGSDVTPFLQKFARYSPASEEALDLAAVRAWEDYGEEVGSAFMATLRTMPEKQSRPLMQLPPVIFNADDDCFYHQPADGLFQCLSSDYITMHLIAAARNGASFFSHEDAARVSKENWENYKSIYSSFFAQGHGHRHLNTSLEAATFLRTPGDLFFYDGALSVGRNPSFYLNAGMHVSRAWALRELARGVLRFAKERRPRAKQEWFCDQSIISTLRYYSRMFEVNEGLLFGTGHRKDGELVRDYFGLPVGLLSVDSLTEFMFTSHLRRRKKLGELTAYYIRHRDEMFFTVPDSDLIAKSSGMFITSPLWGREVPQRCIDVPLLDDSVSIRCSRALRRRVFSSFIHFAAGSKQRYYRLYREWFAWYFATRHSSKALLSAMTVLEKLKLELWSNETLQRIPFFAVCPSPFHSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLD5</accession>
    <name>A0A088RLD5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TYRS</name>
        <name evidence="11" type="ORF">LPMP_141370</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697366.1">
        <property type="nucleotide sequence ID" value="XM_010699064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLD5"/>
    <dbReference type="GeneID" id="22573404"/>
    <dbReference type="KEGG" id="lpan:LPMP_141370"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140019600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_141370"/>
    <dbReference type="eggNOG" id="KOG2144">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="197206at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000085">
        <property type="entry name" value="Tyrosine--tRNA ligase 1 cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050489">
        <property type="entry name" value="Tyr-tRNA_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006330">
        <property type="entry name" value="PRK08560.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264:SF4">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264">
        <property type="entry name" value="TYROSINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN96713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="685" mass="75048" checksum="4634C6334E4DCB7D" modified="2014-11-26" version="1">MNADERYELLRSVGEECIQDAELRSLIERKPAIRCYDGFEPSGRMHIAQGIFKAVNVNKCTTAGCEFVFWVADWFALMNDKVGGELEKIRIVGRYLIEVWKAAGMDMDKVVFLWSSEEITNHAGTYWRTVLDVGRQNTIARIKKCCTIMGKTEGTLTAAQVLYPLMQCTDIFFLKADICQLGLDQRKVNMLAREYCDFIGRKLKPVILSHHMLAGLKQGQAKMSKSDPDSAIFMEDTEEDVTRKIRQAYCPRVKQSANVITDDGAPVATDDRNPVLDYFQCVVYARPGAVATIDGATYATYEDLEQAFVSDKVSEVALKSCLIDEVNALLAPVRQHFASNPEAHELLETVKSYRKDGAVLPLAEAALPAAPEKPHACMWMPALVKVPLDVAEGMIQAAKDFIAAHSEGTVTLVLPDWSAVASDEITGMEKDISAALHVNSTLLKAYGLPEAVKLVMENDVILGNPNDFWVSVIGIARKNLLSHVEELYGGELRNAGQVIAALMRVATTLMLSASHVISNSLDGQINTFAREYTKGRIECLQAQEGSVPALHRPGAAPAVLGADDVLYLDDNDMDIRRKIKKAYSAPNEGANPIISVAQHLLAQQGVLSIERGEANGGSVRYGTPEALVADCCSGALHPADLKATVSQLLLHRSAAARALLNGELKKSIATLRNMEKMAKRRSTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLE0</accession>
    <name>A0A088RLE0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA sliding clamp PCNA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_151400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processivity during elongation of the leading strand.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the PCNA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697515.1">
        <property type="nucleotide sequence ID" value="XM_010699213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLE0"/>
    <dbReference type="GeneID" id="22573560"/>
    <dbReference type="KEGG" id="lpan:LPMP_151400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150019600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_151400"/>
    <dbReference type="eggNOG" id="KOG1636">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="534348at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043626">
        <property type="term" value="C:PCNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019985">
        <property type="term" value="P:translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00577">
        <property type="entry name" value="PCNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00317">
        <property type="entry name" value="DNApol_clamp_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000730">
        <property type="entry name" value="Pr_cel_nuc_antig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022649">
        <property type="entry name" value="Pr_cel_nuc_antig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022659">
        <property type="entry name" value="Pr_cel_nuc_antig_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022648">
        <property type="entry name" value="Pr_cel_nuc_antig_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00590">
        <property type="entry name" value="pcna"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352:SF0">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02747">
        <property type="entry name" value="PCNA_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00705">
        <property type="entry name" value="PCNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00339">
        <property type="entry name" value="PCNACYCLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01251">
        <property type="entry name" value="PCNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA N-terminal" evidence="6">
        <location>
            <begin position="50"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA C-terminal" evidence="7">
        <location>
            <begin position="176"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA C-terminal" evidence="7">
        <location>
            <begin position="278"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN96862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="342" mass="37700" checksum="D84C6126504560B1" modified="2014-11-26" version="1">MGIRKPTPVRHTHTPIPAHTHIICPHLSVCVSYSIGHHLANNTPPLFATMLEAQVQYASLWKRLIECINGLVNEANFDCNPGGLSIQAMDSSHVALVHMLLRDDCFVKYQCERNIILGLNLASLAKVLKIVDSNDSLSLRHDDDSDVVTLTSENPEKTRKCEYQLKLLEIEAESMGIPEMDYRSTVTLNSSEFSKIVRDMQVFGDTVTIAISKEGVKFSSSGDVGQGYTFLQAAGVSDRSAKSEVKSEVKAETRDENDDGPISRKYNKAEGGNGAIGVEVTLEEPITLSFALRFMGIFAKGSTLSERVTLKFAKDSPCMVEYGIDNVGYLRYYLAPKVDDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RM90</accession>
    <name>A0A088RM90_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cyclic nucleotide phosphodiesterase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_170940</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697785.1">
        <property type="nucleotide sequence ID" value="XM_010699483.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22573837"/>
    <dbReference type="KEGG" id="lpan:LPMP_170940"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170015500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_170940"/>
    <dbReference type="eggNOG" id="KOG3688">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="546632at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="4">
        <location>
            <begin position="999"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="391"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="517"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="641"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="690"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="780"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1364"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="408"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN97132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1632" mass="170935" checksum="90B900FCB948ACA7" modified="2014-11-26" version="1">MLPTIPKRGRAPKPFDAGPAIPTPGRPDRETGEAGGRALSVELASPLGATGVFASKSLHGRGHLLHLGTFSSIGFADAVTTQDHPVPTSAGEAVRVGRDGGQPQCSLRPTVMDMLATGPTAAGVLPLPSEATSLQAADLVTGTPMISSVPTSNQSTPVADTRSVQLLQQLQQLLQSGVPTAMLQQWVSGQLLQATAPAASTRPAAAVVVVSPPSAGRLSPTALSAAALGQPLSPGVPSGSRPPRRPASAVSFSLFANQLSHTQQQRQQLSPQHGTPLDSANVAVQPSSAAPTVGSLCTANSGSVPSALTSAVDGGEVTLAPAMCSATSVAAVVLSEPEIGAPLSGASLPCSAGSAMLPPLESVPSSADDPLASGAGNDVDLAAAHHRGAGGSLLKASHPHPQHSQWRSFRNQSSSGVRSSSATSLGGKRPATVSGTGANISAPTIILHSKSPSPAGTPRHCRIASALHSATKAAIHATTSQLVAQNQQKNISLLLGERFSRHPENFVRRVTTRLPVVDSGSPGTPALSEATSGAALSARRSHPGSDSNTDDDICSLSTATTALERLNGSAGLLVAPQTRSPSVASVPLRVAERSVMAAVEFPSRCLPLISVATEASGGSPTSKFFTSCSPRSITSPALLTAATEHPGNGSSEGSFLQDHHSVSDDRGALSIAPCDGNDVATSAQALFSASVESAPAHQRSNNIPPEKPTDGEAGGPLKLSLHQRRLSSSLSGLMSGRTPTVAIEAAAEAASGDAAERVAAAEVPDVVFLIEIDTEATSASCTPAREATPHNTSSLFSGGDSGHLAHSWGGTATHAGERPQHPHRGSISTLPAVSASATSLAWVQPSPNSSSPAAALATSLSQFAPSPSAAARCTHQASVTPWQTTSFVSTTSSHLGCGGATGGHGPSVAFNVTHCDSLSLHDEIPSLGSGPTAGVSSLGEGMNGNRRGRSSVLHLSRSSMNGGVDPMEGVMASFILDDINGAPRRSGPRFLRSFCRHTPVRATESVAHAALEGLGVPFIEGIDHASVPTNVLAVMNAYGFTDRRAFYVAICLNVFLRYEFVQRFGWNVQKLKKFLEVAATYFRDGNPFHNPVHAVDVVMAAHQWLSEGSTGAALSDDEAMTFLLTAMVQQIAHTGADNRLLGQLKHPYAMLCSYASPQQGATVALVMALLSRPELHFFPDPCLATAHTTGIGGAADPAVVQEWTNSRELQMYDMLADLIMATDERNHATLRHNIMRMGEENARLHGCMCASTHADRSYSILSRSLFRSTSQADATTQLQYPSPQGNFCLNCCAYITDVHVPDLLKAVLHFIDFAYLFRPYQVYLCGSIAYMAELYRQSEREYALLQRLQEQQLLRALTRRASGESLGETVPQQPSGAQSPGAPFSAPTTDAYTPAVTFATALLAEQQPWRQGVAQASTMTSLQRSSDEVTVAADTPPPSCRATVVTLPSEMTASHHAVSPSPLTLQVTRAPQDEGAAASNTLDRATRAQPLKGLGRDIVLISMEDLCLPFLEQLAPYMPEAWVAASYQNHQRLMKSLPTPEKFDEVVNRFLDFGVATEAELLEEDTKKEGEIEDEEADSLAAKCPFTLPWRLLRPVRPIAAEWTADKDGVMRRVVREIMRGPTQLLKESDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMD3</accession>
    <name>A0A088RMD3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">3'-nucleotidase/nuclease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_120410</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclease type I family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009381">
        <property type="protein sequence ID" value="AIN96369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697022.1">
        <property type="nucleotide sequence ID" value="XM_010698720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMD3"/>
    <dbReference type="GeneID" id="22573047"/>
    <dbReference type="KEGG" id="lpan:LPMP_120410"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_120009000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_120410"/>
    <dbReference type="eggNOG" id="ENOG502RYME">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="441446at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11010">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.575.10:FF:000003">
        <property type="entry name" value="Single strand-specific nuclease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.575.10">
        <property type="entry name" value="P1 Nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008947">
        <property type="entry name" value="PLipase_C/P1_nuclease_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003154">
        <property type="entry name" value="S1/P1nuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146">
        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146:SF10">
        <property type="entry name" value="STRAND-SPECIFIC NUCLEASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02265">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48537">
        <property type="entry name" value="Phospholipase C/P1 nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839004" evidence="9">
        <location>
            <begin position="29"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN96369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="368" mass="39410" checksum="02E8EEE821A2A854" modified="2014-11-26" version="1">MAAFAFHISVLRAAVVAMLLLVALPTQAWWDKGHMSIAEIARRNLNPDVLEKVQACATALNEVGPFPKSTNIVELGPWADDLKSMGLSTMSSWHFVDHVYNPQNIPLTINPVEIVNVASVIPMLVSAITSPTATSDTIITSVANLIHFVGDVHMPLHSADLFSPEYPLGDFGGNKQIVIVDQAAGTSMKLHAFWDSMCEGPQSNAVRPLDDASYAALSAFVDNLVQTYSFTEEQMMTTNSTVMAAESYELAVKNVYPGISDGTVLSESYKANGKILAGGRVTLAGYRLATILNAALAGVSMDTIMNGTKHIQDEVKVTHTGDTYNYYAYSGVEKGAAAGIFLSSFAIGCLLATAVVIPILYLLRSSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMJ6</accession>
    <name>A0A088RMJ6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CFA20 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_170270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697718.1">
        <property type="nucleotide sequence ID" value="XM_010699416.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22573770"/>
    <dbReference type="KEGG" id="lpan:LPMP_170270"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170008000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_170270"/>
    <dbReference type="eggNOG" id="ENOG502SKJ2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266986at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="804"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="964"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1022"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1111"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1210"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1310"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="535"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="964"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1310"/>
            <end position="1324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1367" mass="140951" checksum="E67275AF89DF69A9" modified="2014-11-26" version="1">MSNAATPPAALRVGSAAILSKPPPNATQTSPSLRLTSSAASTVAAPPHRAIPCFVLFSPQGPHPLEGLKTVTLERLSDGAVATPRRGYLRTRGSSLNQLPADVSLPLSASTMAARHRTAKHVTASAAARASHQSTSGIRCVYDRDTRSQLLHITPGTEVDFSSCMRLPALATKPAPVVGAAATPMLFAATAVHTIVVVQFCVAAPVLSPAARHQAGAPRLQLPASPIPPPGSFHIELVLRTGTSANTVRGRNSASGSGSSGSSGGGYRLRFTNTGSGVQRHTHHTKIPLLCVRTAQWVQLFLDLEALLQSCQEAGAVIVGGGPHCRLQHLRIGSGGSAASTGGIYVRRIIAGHGLALPHPVIDHLITSGGVPGVVAVVAMPSGGAPETFRDADGEGQSSRRDSGTLQQFSSGGGSSWAPPEALRLPAEAGESLCVFVRTGDEYILSEAPALPTPTEEPSPEDVSHVRDRDDGVGVTQLLLKASNCAGDVGMSLTECAAAATQEAARRRPAQAVKATATKPLTSPLSSALPPPQPQRRQLSSQQQQSPASWTSYQGHPEGGAAAVRAFKRQPRPPRVPHCTALELLRMHNHRQHLQPQLVHQFAVSGAATHTPSPADPPSPFFPFSASPLSSPVDASSLSVSDDAEMFVVREVSAAEQLAPATPPQYPANQLMTGKPPLCCPQSQPPIAEKVTHHALDAGPTGEAAVVQHERENVALEDADGEGFSTCPAAAATGFLFSSNTSTITTTTTASEASVLSVLSYSSAVELMDEMNERVRRIHTVLAGAEEEAAAAAAAVIVDRSLARGPPSRHFTPPPTAQGGRPAASTSALIALPILEPPPLTDAAAIHSSSPPPSAPATTTPADYMKAALDDTVCDAVVAAAAVLNTPPKSPTATAKSDGVGRVAVEDHTPRLLPTSDNTKAVLELWSSTEMPLYLPAPSQRPATAAVKGASLMERLRERQATLSSSLSAASVSPVNSGDNGGLGDAPSGAMLPPTSAVTSWTFNSASLTPQSPSILRLPTARSAGEGLPGAGGVPSNHATGAERGEVTPPLWPLSELRTTAPERVAAIVPSSRSSAGQVTKAVVWRRPVPVPDHPPSIGDATQRALQDEVRLTDTPLSRRAGAPEAEGGGARRMVAWSARQNAGTISSGMHTPLSATVAGKLGVAPQQESCQGFIEAPQLCVGAQAPPLLPSGRSFSTVSSFQMWLPSSPMPTLSEGRGRYPSTTTPSSGGGDRHGGFPSNSSSGVGSGPPRPQLGVAAVLPSARPPLPPPSVVHMPQAAPGLTAPTSSSGAAMGLLPLAQQQQTLGLPAATSTRCSPHHTSVSPHEAPPNDGPLSAQLGNDEGRYLYDCVLQCYLDLARNTYVDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RN23</accession>
    <name>A0A088RN23_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nonspecific nucleoside hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">NH</name>
        <name evidence="5" type="ORF">LPMP_181530</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697986.1">
        <property type="nucleotide sequence ID" value="XM_010699684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RN23"/>
    <dbReference type="GeneID" id="22574043"/>
    <dbReference type="KEGG" id="lpan:LPMP_181530"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180018500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_181530"/>
    <dbReference type="eggNOG" id="KOG2938">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="432381at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008477">
        <property type="term" value="F:purine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045437">
        <property type="term" value="F:uridine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006152">
        <property type="term" value="P:purine nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02651">
        <property type="entry name" value="nuc_hydro_IU_UC_XIUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015910">
        <property type="entry name" value="I/U_nuclsd_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="INOSINE-URIDINE PREFERRING NUCLEOSIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304:SF4">
        <property type="entry name" value="URIDINE NUCLEOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01247">
        <property type="entry name" value="IUNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="4">
        <location>
            <begin position="5"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN97333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="313" mass="34257" checksum="8396F001F7565EDC" modified="2014-11-26" version="1">MPRKIILDCDPGIDDAVAILLAYGNPEIELLAITTVVGNQTLEKVTRNAQLVADVAGIVGVPIAAGCCKPLVRKVRTAPQIHGETGLGTVSYPSEFKTKLDKRHAVHLIIELIMSHEPKSITLVPTGGLTNIAMAARLEPRIVERVKEVVLMGGSCCIGNASPVAEFNIFVDPEAAHIVFNESWDVTMVGLDLTSQALATPEVLQRVKEVGTKPADFILKILEFYTEVYETQRNTYAKVHDPCAVAYVIDPTVMTTNRVPVNIELNGELTAGMIVTDFRYPRPEQCHTQVASELDFSKYWDLVIDALKRIGDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNN5</accession>
    <name>A0A088RNN5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_151420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697517.1">
        <property type="nucleotide sequence ID" value="XM_010699215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNN5"/>
    <dbReference type="GeneID" id="22573562"/>
    <dbReference type="KEGG" id="lpan:LPMP_151420"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150019800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_151420"/>
    <dbReference type="eggNOG" id="ENOG502S6MX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="239166at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="125" mass="13789" checksum="F355289CA2F63918" modified="2014-11-26" version="1">MSCTAKCGGYGSLRAECAREPCMANGMCTLLDPSASDCVSWCCTSRSGHVFFLVFFFCAGTFALCASYYLYRLHQINLEGGAVQENGEAVVMTEPPTEEEMTVARRKKRTVVVDPELLKELESQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RP29</accession>
    <name>A0A088RP29_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_203570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698559.1">
        <property type="nucleotide sequence ID" value="XM_010700257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RP29"/>
    <dbReference type="GeneID" id="22574568"/>
    <dbReference type="KEGG" id="lpan:LPMP_203570"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200042000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_203570"/>
    <dbReference type="eggNOG" id="ENOG502SITS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267140at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="46"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="243" mass="27248" checksum="70A9D90A1F7B83E4" modified="2014-11-26" version="1">MSEARSSPVFMAVTPHVAQRQEALRQLERLPHDVLSGMLCDVKAQLQQERRALSDGQKELEHVQLQLARLNKVLKTVQRQREQEHQQASKCADAVARTSRLLRAARRRGPKYEEAIARTLDEIHEIRRGHVAVTAPPTSPSAISVDMDVSFINASAQHHADVSVGMAVPPTLARESNRAAAAARAANEGQRLSVFLHALEKRVARVERENRMLLRSIDILNRGDASSARLYHELESLRFLRCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RP53</accession>
    <name>A0A088RP53_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">carnosine N-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_201030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnosine N-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.22" evidence="2"/>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698302.1">
        <property type="nucleotide sequence ID" value="XM_010700000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RP53"/>
    <dbReference type="GeneID" id="22574310"/>
    <dbReference type="KEGG" id="lpan:LPMP_201030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200014800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201030"/>
    <dbReference type="eggNOG" id="KOG2798">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="978at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030735">
        <property type="term" value="F:carnosine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012901">
        <property type="entry name" value="CARME"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303:SF6">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07942">
        <property type="entry name" value="CARME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01296">
        <property type="entry name" value="N2227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN97595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="456" mass="51203" checksum="90D9E2C93F599F73" modified="2014-11-26" version="1">MSADQQATGCGGNNGVLAAPSPQTPHAISNMSNEAQDYEHQGVSSPPYSMESAINQAIPLYQPHAPAPGVVIDPDMVEDHISFLRTVRAFHHYKRQALAAREMRCTNFRKLQDQHRDLLCIDLDKILDKYLECIEVNSTFFDAICEASEELFDSYWPEGTTVLMGDVPPPTPLDMNKVFSTLRQFVRDWSAEGVAERDCVYKPILDTLNRCFPNRSERENVRVLIPGAGLCRLSVELALRGFFAQANEFSYHMLIAGHYIQNHVFESCQHKIYPYSDSTCNLVNRADQFAEVQIPDLCASEAIDALRDTGLSFGQLSMVAGDFTEVYAKSHQHKTWSVVATCFFIDTAHNIIEYLEIIYNLLVPGGYWVNVGPLLYHFADSADDMSIELSLGEVLTVAQRIGFVLNGPPSFIDTTYTNNQRSMKQLVYRCAFFVLQRPLAETQKEAIDCVVKVKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPF0</accession>
    <name>A0A088RPF0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_204900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698689.1">
        <property type="nucleotide sequence ID" value="XM_010700387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPF0"/>
    <dbReference type="GeneID" id="22574702"/>
    <dbReference type="KEGG" id="lpan:LPMP_204900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200055800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_204900"/>
    <dbReference type="eggNOG" id="ENOG502RFVS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276081at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="248" mass="28999" checksum="704DC80DC05F533B" modified="2014-11-26" version="1">MLRRTLSCCNRPKGPPGLRPGKEYRLTVPYRSEVTMIRQANFKKFNSNIRELFKKPLEMNNIKAVPRDLGELPRNYVLKLLFFHQPIRLLDLWELCKQHNDVPLDSARHLRLVLKIAKLQKWAYAEKNQTDNLYYYYVHQSRIHEVQQMVRHDEVVKRAQEADSKRQIVRQEEGRQAREAQSLDDHIIALQNTLVSNIGHIRAFDPTFVDTKPYVMESGAVNCAWHWEGAVDTATQEASSHAEKNSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPG5</accession>
    <name>A0A088RPG5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DoxX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_201810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698382.1">
        <property type="nucleotide sequence ID" value="XM_010700080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPG5"/>
    <dbReference type="GeneID" id="22574390"/>
    <dbReference type="KEGG" id="lpan:LPMP_201810"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200023500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201810"/>
    <dbReference type="eggNOG" id="ENOG502S4U5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271906at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839057" description="DoxX" evidence="2">
        <location>
            <begin position="23"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="156" mass="16976" checksum="F982C34C2788036C" modified="2014-11-26" version="1">MLRDLLRYTGLTLVLLVFITSGIDKLASPSVGAAQLAKSKFPRMLAAMGATLSPSEYIHLVRGTGVICVCFSLFILLGVGRSFFSFLMAIGMIISTVAFYVDYDYPLAITEGNIQHMLKNMSVAGALLFVSGSGHRSRRYTQACDAKSNIQARKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPN6</accession>
    <name>A0A088RPN6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_205660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN98057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698764.1">
        <property type="nucleotide sequence ID" value="XM_010700462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPN6"/>
    <dbReference type="GeneID" id="22574778"/>
    <dbReference type="KEGG" id="lpan:LPMP_205660"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200063800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_205660"/>
    <dbReference type="OrthoDB" id="272021at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="268" mass="30502" checksum="1B960B293FAEA32B" modified="2014-11-26" version="1">MAGMQLVYRSTCSELSPQERVAVFAEERAKGKVTKIAARALCRIMRGGHTNADVQTVLQQLSFHSSTTVPKHYLLASPSSKRTSSQWKQHPHILNAQTHNRSYACRLRRQRRASIIEDHYFRVPKTPLPLSYEAQCDIDYVAGRQHRGRVQVDSGYAPLFSKSSTWTPEAMTTAERCALQCLTPPERSPMMETLEKLKSQGHYKPSDPMARIRFNEPAHMPNLHRRIPAECVPACSTKPTMCFEKHCEGNAERATHNMAAKEYAAWHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPU2</accession>
    <name>A0A088RPU2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small nuclear ribonucleoprotein Sm D3</fullName>
            <shortName evidence="9">Sm-D3</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">snRNP core protein D3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_203600</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the snRNP core protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698562.1">
        <property type="nucleotide sequence ID" value="XM_010700260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPU2"/>
    <dbReference type="GeneID" id="22574571"/>
    <dbReference type="KEGG" id="lpan:LPMP_203600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200042300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_203600"/>
    <dbReference type="eggNOG" id="KOG3172">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6425924at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01721">
        <property type="entry name" value="Sm_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000058">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034099">
        <property type="entry name" value="SmD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9 12" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="5"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN97855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="113" mass="12287" checksum="BC419C3D8A738EB3" modified="2014-11-26" version="1">MAESIPIKVLFDALHLKVSIEVATGEVYHGIVEELQNNMNVLLKNATKTTRGGKETKMDSVFVRGSNIVFFQLPDALQTSPALLRAGEIVSKAKDTRGDGKGFGASRKRARNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQQ2</accession>
    <name>A0A088RQQ2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ABCE1</name>
        <name evidence="6" type="ORF">LPMP_210740</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698862.1">
        <property type="nucleotide sequence ID" value="XM_010700560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQQ2"/>
    <dbReference type="GeneID" id="22574896"/>
    <dbReference type="KEGG" id="lpan:LPMP_210740"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210012100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_210740"/>
    <dbReference type="eggNOG" id="KOG0063">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6593433at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000144">
        <property type="entry name" value="ATP-binding cassette sub-family E member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000152">
        <property type="entry name" value="ATP-binding cassette, sub-family E, member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013283">
        <property type="entry name" value="RLI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009945">
        <property type="entry name" value="PRK13409.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19248">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01868">
        <property type="entry name" value="ABCEFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="54"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="78"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="352"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="604"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="607"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="644"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN98155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="659" mass="74220" checksum="AD0100229F602312" modified="2014-11-26" version="1">MPPRKQVEEQSRLTRIAVVNSDRCKPRKCNLECHKCCPVVLQGKLCIEVNHQSAISKISEELCIGCALCVKKCPYDAIRIINLPSNLERDTVHRYGPNSFKLHRLPLPRPGQVLGLVGANGTGKSTALSILKGRIKPNLGRYMDEPGWDDILKYFRGSEHQAYFQHLLDDKMRVLLKPQYVDKVPKTNNGVVETLLSKADERSMKDHFMDVLDLKNVADRTLDKLSGGELQRFTIAALCVQNAQVYMYDEPSSYLDVRQRLTAAQVIRSMLTETNYIIVVEHDLSVVDYMSDFVCVLYGVPGIYGVVTMPYGVREGINIFLDGFVPTENLRFRDESLTFHIADEIEEGVSKRRAMNEYPAMTKSLGSFSLSVDAGAFSDSEILVLLGENGCGKTTFIRMLAGHVKPDNDVEVPKLSISYKPQKIAPKFQGTVRDLLQTKIYEMYCHPQFQTDVLKPLTIEELLDQEVQNLSGGQLQRVGLCIALGTPANIYLIDEPSAYLDSDQRIIASRVIKRFILNSKRTAFIVEHDFIMATYLADKVIVYDGTPAVNCTARMPCGLLEGMNKFLKSLNITFRRDPTNFRPRINKLDSVKDRDQKTSGNYFYMTEKTEEPKGKKAPQKDGADSDDDGSDEKPAPKKHQSQFHNDDSTDGKAKKAHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRH7</accession>
    <name>A0A088RRH7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_231280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699285.1">
        <property type="nucleotide sequence ID" value="XM_010700983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRH7"/>
    <dbReference type="GeneID" id="22575333"/>
    <dbReference type="KEGG" id="lpan:LPMP_231280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_231280"/>
    <dbReference type="eggNOG" id="ENOG502SH8C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="263004at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="320"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="379"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="466" mass="52778" checksum="D3E1B9AB5ED82C01" modified="2014-11-26" version="1">MSTTTAQTELASVCKNIQSVLSKIKETSAKRHDQEQRLISSVASAKCLAGSFSVYPPTNDEVVQVLKSSGEEEQVEVECLQRYRRFVEAKRDCFTAVEADMCTVSKEITNIFGANEKTEVPTNGDYRLGVEENQCEAELLHLFRLWRTVVCLHDWVLAPLLKRGIDVPRYELQCTNADEERSYARELALRNAVADTQAMLFEVQKRLRDLTMEAEALRITAESTTLLRFQDSATVLISDERDEALAASIRQGLHELQQSSERLRRKKVAVDEDAASLMEKVRNLNSQIAVCNCSMEAFSQNSREAADDANGLVNAKTDALRTLHRKAQEYAAEQELLERDIGNYEQLCSLLMERAANDDSKVKLTVAAEQAYHSLLSEEKIQQEKLTRVQLSIESLENEVRDASTERQRILGEVQYLSKLVSNATVVKRVLARAGEECDPVRKVTVIDDYLRFVQKARLERHGFYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRV6</accession>
    <name>A0A088RRV6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_231820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699337.1">
        <property type="nucleotide sequence ID" value="XM_010701035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRV6"/>
    <dbReference type="GeneID" id="22575387"/>
    <dbReference type="KEGG" id="lpan:LPMP_231820"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230026300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_231820"/>
    <dbReference type="eggNOG" id="ENOG502RZZK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="240966at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="965" mass="104073" checksum="30041B374B927F1B" modified="2014-11-26" version="1">MSSASLAFEPPTVVAVFASHAVLCWEQPRTPHAKSFVRHIAWEYQIEYNCSCRARQQPYRTTGSDTFVLLATPHVGETYYVRVVAKSSLAGSTTGLSSAKVAFTASCNVGIPWRCASRPPVCVFDALYLAANVAAGGISALRDARSSTIDHAAELDGEHLCYTLEGDVAVHSYRIVYSDTSALPIGQARTVYYMVATARLHAGRRTCAMELLSMIQHEGASLVFCGVGDSGRLALRAALSFLSFLTTACPALCTSVFCITYGTSRLLLKEGPRLLAHTLPLSGQLLHFTQLPLIDDALPIWDMAALSQRGSGVASDTPPLGYANGFYRNMLLGVQCRVMDGTGLHFSLSSPDQLLTVAEEAEVFDAAGQLRALLGLFFPSSPRWLSPSVASVRCRTEGPLLHVVVEGTNLHYCPRVTLAPSYQRGTALFPRVTASTPLQLECTACLLPWAQQCVADDDLCDAIASGVSAFLLVQTSMGTAFSPGLATVALPEDLLELFRAAQQDSAPWSGEAAPGLVECALQLQPLYALASPDVTISPTAMSNVLHNPLFELLCTLASAAEVVLSPKYADSTAKPGSGMLGLIHSVSARLSSRKADTRADAVPALHVPGIEATLLKNALKEWKGVGFTGIEAWTSRCASWRQRLFYGLPLLRETAYRNTLMRMLHTFDGGAEVGDDAPLACIEAYLYAYTKYHIRAAQPSPVHMDKSLCSELSLSSFYGAVAPIFKTEDSSASGSPLPYLRESMLLWALCHCFELRREVARTTFCCNVGCAGCGVSTLSTSISSLLHREEARRYSRCGTFFRTVQCRVASSRLPAIHLAAQTGVRCCVFLAGEVTDLTRPQYTSMGVRIQEHLTYAGQHLFRVATKADEHLQGSSNLREELASDASVAALMSRMGAEWVGGCGSEVQRLVVALAPSTSRLVELIACSPVEAEQYAQRLRSYSEALLLDCLRFGILRGDANCTKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRX8</accession>
    <name>A0A088RRX8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_240850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699425.1">
        <property type="nucleotide sequence ID" value="XM_010701123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRX8"/>
    <dbReference type="GeneID" id="22575494"/>
    <dbReference type="KEGG" id="lpan:LPMP_240850"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240014500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_240850"/>
    <dbReference type="eggNOG" id="ENOG502RZZP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="759142at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839083" description="GOLD domain-containing protein" evidence="2">
        <location>
            <begin position="30"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="3">
        <location>
            <begin position="29"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN98718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="226" mass="24969" checksum="CE932A59B53E58CE" modified="2014-11-26" version="1">MPRAACPCVFMALAIVVLLVGGYSTGAHAFRFSVVPGKVKCFTSEQPEGGRYELRYRMMRSLTPFVSVAVTSRGGRVLMEHEFAKPDAKEIVVVNANSLISVCFHTSEKASKAAVSTSVTLDIVDAEDAELTRVKKQSYSTSSPITLGAGKGSGAIQQMQYIYETFASMRMALVSLTRADEDIRYSLMEAERFSWLFVYIFVGIGALITLGSFVRLRIFMKKRKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RS62</accession>
    <name>A0A088RS62_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA processing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_240770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699417.1">
        <property type="nucleotide sequence ID" value="XM_010701115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RS62"/>
    <dbReference type="GeneID" id="22575486"/>
    <dbReference type="KEGG" id="lpan:LPMP_240770"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240013700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_240770"/>
    <dbReference type="eggNOG" id="ENOG502S2P4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267415at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045166">
        <property type="entry name" value="Spp2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15818">
        <property type="entry name" value="G PATCH AND KOW-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15818:SF2">
        <property type="entry name" value="G-PATCH DOMAIN AND KOW MOTIFS-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="392"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="557" mass="58826" checksum="ACA76A4F8D3FC7D8" modified="2014-11-26" version="1">MNSSGDAPPHKRLASEQFKRDNDTHVGAREHTNGASALSARARFLRELEQYASDDDDYGGNMGTTVASAGPVRRMGHANGAPQSSSACPRAPTTHAATPSVGLPSRADFFFGEEGDVHDEADEDAVGDDAVGNTAPAASSTSFFTGASTNTSDTNGGSAAPSRVGMQLLHRMHALNTSSDHRRSARDAAANPAATGEKGVHHIPFTQTSSGDFTVVHTYVPLSTGGFLSTANAAHDTMEGHQVRIGDILSLRKPLSGADPSPSHAVTSTTTSSPPTSTAPSTLTTDSAVAAVAQKVMSHFRSAASLTPEERKYGRQLTADMMHSLFEVTRVDQQGRSIEALFLDGTRAKVSFFEVRPAGYVEQRMYAVWKADPASRPVTIIHSNASTPTTPSAPNGAVVPSSSPSPALQPPPSVTAAAWWVIPHLLVRLTAEAAGDWCGKKCVVKSVQRNENRIRLTEWVEGSSSGESGSRSVHNSGKLTVAAAEMRELIGVDGLETVVPKKGGRAMVVLGNRRGEMCTIRNRVRGADGELMAVEVEISRTKEVMTLQADELCALAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTE3</accession>
    <name>A0A088RTE3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Farnesyltransferase beta subunit</fullName>
            <ecNumber evidence="10">2.5.1.58</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_261450</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.58" evidence="10"/>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699965.1">
        <property type="nucleotide sequence ID" value="XM_010701663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTE3"/>
    <dbReference type="GeneID" id="22576048"/>
    <dbReference type="KEGG" id="lpan:LPMP_261450"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260019500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_261450"/>
    <dbReference type="eggNOG" id="KOG0365">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261146at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF6">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="9">
        <location>
            <begin position="95"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="41"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="198"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="451"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="456"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN99258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="728" mass="78920" checksum="9AA861392521B909" modified="2014-11-26" version="1">MNLAPDTITTEAQRKTELLLLDYLRSTNPHVYALWKYHPDKDKDDSSFSAASSSSSPDANRGAGSDDHDDESASASSCSAEPTLTDPFVCEWPRFHRAAHVRFLMENLNAAPQGLSGLYPSRPWIVYWALQAADVLNVMENEVLHRTPPSAIVAFLHSCLSIDHTCQAEVNNRLAVAAKSTSKAGEVKVTHTTGTLAGSSTTSVIPASDSDDATSATFMPPEGTAEVIDGPSRPVIGFAGGARHQEPHIASSYAACCALAILSWYEDGASLRQLPRAAIKRWLLTLRNEDGSFRVHGGGESDIRASYCAAVMTTLLGLDDPESFDGEAGRREFVDDVRDVPVLTVQTARFVAACQTHEGGFTCSATASEAHGAYTQCGLAALLLMKQPHMVHQTSLRRWLAARQLNCEGGFNGRTNKLVDSCYSYWIGASHVLLRTVEAYTKCFTEVPITPSGNEDSTEANEDGGTEDGDSSPSSRCLRAREVLLLDHAQLLDVKMIHASADDAWDHAEGEYLTRLDMVDQFLGADDEVLRSAEGKKAANTALYERLLETQLAAERSSNGDGDAAAGDVQGSLEAWRARQAFLYADVGDFYFNQRKLQDYVLRCCQDPEIGGLMDKPGTAHDGYHTCYSLSGMSAAQNLQYRTHATAATVAAYTSPYLGRAFARSYLPARESSSMRSSNEASYGVVLDLSSTSAAAESMILQTTNPIFNIHQSRVLSALRVWSAKTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTJ2</accession>
    <name>A0A088RTJ2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucosidase 2 subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_260970</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699917.1">
        <property type="nucleotide sequence ID" value="XM_010701615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTJ2"/>
    <dbReference type="GeneID" id="22576000"/>
    <dbReference type="KEGG" id="lpan:LPMP_260970"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260014500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_260970"/>
    <dbReference type="eggNOG" id="KOG2397">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28322at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017177">
        <property type="term" value="C:glucosidase II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039794">
        <property type="entry name" value="Gtb1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036607">
        <property type="entry name" value="PRKCSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028146">
        <property type="entry name" value="PRKCSH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630:SF1">
        <property type="entry name" value="GLUCOSIDASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630">
        <property type="entry name" value="N-LINKED OLIGOSACCHARIDE PROCESSING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12999">
        <property type="entry name" value="PRKCSH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13015">
        <property type="entry name" value="PRKCSH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839076" description="Glucosidase 2 subunit beta" evidence="6">
        <location>
            <begin position="24"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="7">
        <location>
            <begin position="380"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="165"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN99210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="497" mass="55928" checksum="CA891533577E4308" modified="2014-11-26" version="1">MAAMRWTAFAVALLCIVVIPVYARVFGVLHHHAAYFDAAQKVGAFRCLDDSATIQFSSVNDDICDCADGSDEPGTSACIALRGSTVTLLPPEWKFQCTDDAHISQVFPHNRVNDGICDCCDGSDEAETPVLCANRCAEVAKELMVQRHTEQESNRKSAERKAEMRIAAQRRREEVASDLAALEAQHAKMVSRLAVLEERKIAAEKEENAPLAELPMKANESDVSHVENEFADDATFCIQWRETDDCIPNGSRLSNMDKECFSVIDSGSSGYCECWANFRRDESDEAPKAGLEREAKGDEVEMHMNIITYNFSCGHPTLTCMYVCAHNGEVGVDEGHEKVQHFSTLTVAEEYYIIKDDLDGLETRIKDAKKRLSPPTITTEELLLTLEGMEFNLDNNEHTYKIIMFDRIEQCDLEKVSYSILLGKWNSFAESTYSTWTKDTRDFSRMIYDDGLECWNSGSRRVEVHLVCGPENKLVMVEEPSFCKYSMMFETPAICDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTY7</accession>
    <name>A0A088RTY7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glutamate 5-kinase, putative</fullName>
            <ecNumber evidence="9">2.7.2.11</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Putative glutamate 5-kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_262680</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="PLoS Negl. Trop. Dis." volume="10" first="E0004326" last="E0004326">
            <title>The Dynamics of Lateral Gene Transfer in Genus Leishmania - A Route for Adaptation and Species Diversification.</title>
            <authorList>
                <person name="Vikeved E."/>
                <person name="Backlund A."/>
                <person name="Alsmark C."/>
            </authorList>
            <dbReference type="PubMed" id="26730948"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">L967/96</strain>
            <strain evidence="10">MHOM/PA/71/LS94</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.2.11" evidence="9"/>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KM411792">
        <property type="protein sequence ID" value="AKK31237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KM411793">
        <property type="protein sequence ID" value="AKK31238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700087.1">
        <property type="nucleotide sequence ID" value="XM_010701785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTY7"/>
    <dbReference type="GeneID" id="22576171"/>
    <dbReference type="KEGG" id="lpan:LPMP_262680"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260031700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_262680"/>
    <dbReference type="eggNOG" id="KOG1154">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="409889at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04242">
        <property type="entry name" value="AAK_G5K_ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000006">
        <property type="entry name" value="Glutamate 5-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041739">
        <property type="entry name" value="G5K_ProB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011529">
        <property type="entry name" value="Glu_5kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654">
        <property type="entry name" value="GLUTAMATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654:SF3">
        <property type="entry name" value="GLUTAMATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000729">
        <property type="entry name" value="GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/glutamate/uridylate kinase" evidence="8">
        <location>
            <begin position="9"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN99380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKK31237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKK31238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="264" mass="29346" checksum="8A49CDEAD9FF6698" modified="2014-11-26" version="1">MAEVLKLVKRIVVKVGSSILVENQEIASHRIEALCRFVAELQARYEVILVTSGAVAAGYTKKEMDKSFVPNKQALASMGQPLLMHMYYTEFQKHGILCAQMLLAAYDLDSRKRTINAHNTIEVLLSHKVIPIINENDATALHELVFGDNDRLSALVAHRFKADLLVILSDIDGYYTANPRTCTDAKIRKVVHEIDPSELVAEATPNNRFATGGIVTKLQAAQFLLERGGRMYLSSGLQLETVRDFLIGGHHELGTLFYPRVLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVJ0</accession>
    <name>A0A088RVJ0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sodium/sulfate symporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_283080</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700647.1">
        <property type="nucleotide sequence ID" value="XM_010702345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVJ0"/>
    <dbReference type="GeneID" id="22576753"/>
    <dbReference type="KEGG" id="lpan:LPMP_283080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280037700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_283080"/>
    <dbReference type="eggNOG" id="KOG1281">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10260443at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006797">
        <property type="term" value="P:polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14447">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF92">
        <property type="entry name" value="LOW-AFFINITY PHOSPHATE TRANSPORTER PHO91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="521"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="547"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="570"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="610"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="662"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="703"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="7">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN99940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="734" mass="81324" checksum="9248E632303CDADC" modified="2014-11-26" version="1">MKFGKRLQDEIVLEWADYYVSYKRLKQFIHNSELRGCEFSDELFNIITEELAKAEGLFQQLMTDLQEEHARLMKMNPNHPVAPERKLRRFYRRKKGDSANDEAPNEETGLVSTATSSVCDPSVLDEEVVPRPQHTGLGALFKHLFLLLIGDSQVKEVESNTPRALFLEWHSNAHQLQHFAELNLEAIRKSAKKLKKHRRMEDDFTAAIEVELARSRLVTLMPRLRNLLSDVSVDFERKFKVPLDQYANVAMSQEWHARWRYISLGAVLFLLVQQLPVLTEEPAAHNCLALFVLITTLWITEAIPFFCTAMLIPLFAVPLRIVMDPATHQSATASLASQIILGKVFNHVQILVMGGLTIAKAFSRTNLEMYAASMLHRWTAHRPSLYLLGVMLSSCLLCAFMSNVAAPLLVLGVVQRTLWEFPEGTKAPHGILLGLAFSCNIGGMLSPIASPQNAVAISALGFYNVSFAQWVTVAMPVVLFSVVAAWAIVLIVWEPFAAVPYIPLQVVNTAAEEQVSSATRVVVLVVSAITITLWILPANLFFGDTGIVALIPIVVFFGIGILSKDDFNTLSWHLMFLLAGGNMLGLCAHDSRLLDIIAMSMKSTLTDSPPYLTLLAVLIAVSIITTFVSHTVAAMILLPIIVKIGFLMPQSTGIMAVTPQSMVMLTALMCSGAMAFPISSFPNVNSLLAEDSKGKLYLRAKDFLVCGTAITLVFMVCLATWMVPLTNYVLPANH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVJ3</accession>
    <name>A0A088RVJ3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytochrome c oxidase subunit V, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_261670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699986.1">
        <property type="nucleotide sequence ID" value="XM_010701684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVJ3"/>
    <dbReference type="GeneID" id="22576070"/>
    <dbReference type="KEGG" id="lpan:LPMP_261670"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230028900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_261670"/>
    <dbReference type="eggNOG" id="ENOG502QVF1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="256337at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="196" mass="22300" checksum="C67C66D4F339272A" modified="2014-11-26" version="1">MKRFCIPTLTSVSFVRTFFGKGWDNAALDTIYSSMLRKPEVNDRIRTQYASTMDPRDADVLRRLGEVSKENKTFIRVFLPPHLGDPHRLLKCYSLMAYPILDDKGGQLKVEMDGHKLDAFADPDDDYSKVVIPHIELVEYLAKSLLETMKWEATPRGAASMLESLYRGAEIPDHVFQTPAVIERLDSFKDGNKVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVW8</accession>
    <name>A0A088RVW8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Autophagy-related protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_270380</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Preautophagosomal structure membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATG9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700126.1">
        <property type="nucleotide sequence ID" value="XM_010701824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVW8"/>
    <dbReference type="GeneID" id="22576214"/>
    <dbReference type="KEGG" id="lpan:LPMP_270380"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270010300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_270380"/>
    <dbReference type="eggNOG" id="KOG2173">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2020634at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007241">
        <property type="entry name" value="Autophagy-rel_prot_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13038">
        <property type="entry name" value="APG9 AUTOPHAGY 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13038:SF10">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04109">
        <property type="entry name" value="ATG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8 10" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="654"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="654"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN99419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="726" mass="81359" checksum="18B1239C2BEDA58F" modified="2014-11-26" version="1">MAWQLRASVVRVPRFTLRFAGSGRIEDMRLFTQTLYTYWYNKGFWGATISSAVDFLNTFVLFIVAVIFTMQFDWGIALSCAEPECAVHPLVKGLHAPYIFRSTFWGHLWGFILVSSTLGSCMYELMRFVETYYLQYEMEEVAREAAVDTGFLTPLHRWSYHLRRGLDGRSGHEFIGLCGGNTIALSTAGWGEFLETICAAVGRSGSVKFGAPGEPLDPLRAVQGLMQLENYLIAIHEAGALQDTALQYVSPSVITALLDSMFDAFRTVESRHKCIWAVRTTMVAHAVFYGAGFLFFFVYVILKVLVKHAAQVKVNYLALSQRMWTTDAQWRFRLYNEVEHLHACRLYAGAEVAERMVDRLRVSNSASRFVRRVCNTCVLVTAVLSFLNPALLISASIGGLTLFWWLTLALMLYACVPELNPREREYAYMTDLERLVDCIHYDAPQWFHSADAFYEHITETFFKNRLRVLIADLLESLALPVVLLYALRDGSVEVLIDFVLQHSTMVDGVGSIAVGSDWSVSSLSRAPPEENDSSEINLTLASTHSNNAEVSATLLGRAAAVTGSTHKRAEKVELSVASFAAVYSQWTLRHIDGQTGRESPTTREDAALNDFLRRLSIRVREAATTQAVSPASADDLTISRDSLAPLKSVRSERRFTTTREDTEQRIDRADGDTSGLPAFAAGCTTAHEREQLFVSQVSLLRHALRFSRAAQRPPHWRDTAGYGTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RW43</accession>
    <name>A0A088RW43_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nucleoside triphosphate hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_301510</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad17/RAD24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701178.1">
        <property type="nucleotide sequence ID" value="XM_010702876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RW43"/>
    <dbReference type="GeneID" id="22577204"/>
    <dbReference type="KEGG" id="lpan:LPMP_301510"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000041900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_301510"/>
    <dbReference type="eggNOG" id="ENOG502RZSU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10265971at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004582">
        <property type="entry name" value="Checkpoint_prot_Rad17_Rad24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="500"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="506"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="525"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIO00378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1064" mass="114150" checksum="1FA85D12E40F291A" modified="2014-11-26" version="1">MLHEVYAPRTVADVAWSRQKTVALSAVIQQARGRGKALPSGAPHIILLYGPPGCGKLAALKVLLCEDATVVAARASTTHGTSRAGAGTTSQLMQSNNTSFHVFHSCEATVQAYAQYLRSVLSYCRGQLGGGELQLPSLAESLTKCISSGGRSSSVESCARAVEGSADLTVPQTSASAELPANHAHIIKFYGEPASHALHRCTLLFLKEYEELRAIAQREEREQKAFPSLNTCAGRRTCLMKHLHRNLIFFLHTTHDTHNDKLDLNTSFPSTLLQSPAVELFHCTPMTEINLRKRLRSILDQEAQRQAQEEQWAAVTPMMGCFAGTLSSSLPSALPATFLNKARRNTKAKRKASTLTSPPATAFTASSSYDLMDSATLEAIVAGSQGDIRQALLQVQWSCLMPASSSLAVTAHQNGAPVKGAWVQAAQAAAEIWVRLEKQRSAAREGLVATGADTAGGRVLSLSDTKDAKLRVYASHSTSCVSAATLASKASAAMHGECRDEDGEIDSERDSDVVEEVSFKDSDETVNISSSTSESCTPPARQAARNGDSKTWNKEGGAASRKRARQSSPPPPAMNMLSLLDSQMERMEVMTSMDGRGACGIKNKPGRVAHRVLAPLAAAAESQPPSVLPMTRDEYLDLSHAVGRLLTQKYCIDEVLDTLNVPPRKILDYLTNNQIRYFGDDQLPQYAHCIDAASDADALRASELSGSFIGVPSATALRERRQLADRTTAGESLGNIGRLLEAIALQLFHLTYRAIQTEVRPPPGFVAQEPPPYFRLAYPRLRDISDGWISSSMHRGERRTEADSTANISEREWVLQALARLESVPTVSAGSSLANYGSSSNRRLRFHNDAGCCSSSLASITPRIQTDEMDVMREGLPDLLYRCGSTEAVLLDYYALAPYILLTVNPSLAPQSLQAGCISASAALASLSRTCGAANATAQSPDVQIAPAAPFLLPPSPDAPTTPAMAPRRTVFRFASSSLSASAPGMMAPSAHPVPPAPHLRTCTPLQLAILQRGRNPAMAQLRSDLFVLSANDVCDRTAGASTESDAVLPLIPDGDDIEDIDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWB3</accession>
    <name>A0A088RWB3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CDC16, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_300740</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701109.1">
        <property type="nucleotide sequence ID" value="XM_010702807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWB3"/>
    <dbReference type="GeneID" id="22577128"/>
    <dbReference type="KEGG" id="lpan:LPMP_300740"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300012800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_300740"/>
    <dbReference type="eggNOG" id="KOG1173">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10006270at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000814">
        <property type="entry name" value="Cell division cycle protein 16, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF9">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="298"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="366"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="407"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="522"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIO00309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="546" mass="61626" checksum="064FD381750AA9F3" modified="2014-11-26" version="1">MDAICVLRENALRLVSGGQPMSALHLVEMLCELQPNSDENRSLKIRCLYELHEFDSVLKLAKQMTFGYDQNSEVFLLAVKAAFELGDLKTCVQHAMTLINADSSKVVAMCFVAKAAELSGDPAKAVHFYKMALEADPFCGEAFSALTERHLLDHWEILELINSLRIPPEIEVYRSSLKARIGCDYITSGISGVPRTLVLLAGAKKEYERNNLRQALSLTTEILEMEPYHRQTLCLHLCILVDSKATPLLFEKAHFLSKNKCYTELAVYAIGCFYYSLSNYERAGRYFSRASELDCYFAEAWIAYGHCYAKLEEGEQALNVYRRAMNFFPGLSVCCTYVGMQYSRVNQRSVARCFFEESLRKNPVDSLVLNELGVLALAEDNPKQALGLFQKAYDSLPNRENPSEHSDCILFNLATMYRKLRQYEAAIDYYNQYVRSRPNASHGHCALGFTYHLSGNIKAAISCYHTAESIKPDSFCRDLLRRALELDFGIRGRLSWDSERPYSSFSPGEVSFSAVSRRLRSESTDADSVTASPPPSVGRSLDFQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWD6</accession>
    <name>A0A088RWD6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">3',5'-cyclic nucleotide phosphodiesterase, putative</fullName>
            <ecNumber evidence="13">3.1.4.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_292690</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.4.17" evidence="13"/>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700873.1">
        <property type="nucleotide sequence ID" value="XM_010702571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWD6"/>
    <dbReference type="GeneID" id="22577032"/>
    <dbReference type="KEGG" id="lpan:LPMP_292690"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_030015400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_292690"/>
    <dbReference type="eggNOG" id="KOG3689">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="568146at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="11">
        <location>
            <begin position="15"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="PDEase" evidence="12">
        <location>
            <begin position="519"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="913"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="158"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="913"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="933"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="606"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="606"/>
            <end position="610"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="610"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="647"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="648"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="648"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="648"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="761"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="761"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="810"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIO00216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1078" mass="119557" checksum="9B970DF343E686BA" modified="2014-11-26" version="1">MSLMPGHPVPRSQWVESAEVCAACGKRFSFFTSKENCPCCGRLFCSSCLSAQCTLFPMAAPKAVCLDCFRKTQDWRLSQLEQHAALTPADVGAASLPLSTSTEALELKLKALDEEFDRTKADTRRLREENDTLIDLLTAKDTCIAELTEELMKAVASADAAAQSAEKLQLQLRDQRESTARQLEEAEQRAASAAQASEAMNAQIQEHMQAKVEWEASAVKLQSAVRKAEDMSVQSAEELRELRAAMKTMNTYSEEKIKQLTAQLQSIVEASTHLQKDYDRNVESLRAAEQSRIASDAAHDKELQRLREDLSKATSALAQAQERYERQQISAPKFTDDAAAVDGVEKQREIATLKEQLASSSAAQRHLQGELDRAVEEALRLREDGALKAEAARALVSELRTQLNAQRTAVQQDLPWEQEANARLRADLAEKEQLVTKLRRGCFEAATAVRAELGDLRGKLVETKLSYEEGLRSWQTWLNELRAAVEAALQQQALISAAASPSDIAALPHVPAATKSRWAQDTIVEELQYVSVSNVNVGTIAPVPGLEKWEFDTVAEAQRGGEADVLMRIGHQIALNLNLFPDRASQHRWVCLLATVQANYRANPYHNRVHAADVMQGVYALICRCPGLLAHMTTVEKRAVVFAAAVHDIRHPGRSEMFLRNTFDAMYMRYNASQVLEQMHTATAFHLLATPELDFTHGDMSDTEALEFHGLVAALIGCTFMGLHASLMEQWSRPLQEGKAYDVTVAADRQQALSLFLHAADIGAQARGLAVAPKWLGIVEEMRAQGDEEAARGLPPSPGSSRSASLERGQLFFMEMFVVPLFDLVHQVFPSIESPMRNLRTLHAHYCAALQETREFPPSVQYRIATKPVSNTVETTRTEALDAREAALKKREKALKQATQRLREATATVADRERQVGEKEAAVMRAETSVSTHRNERRSVPSSIDEEKLLRATTAVIAREARVERGVANVEKMTAALEEREAIASRLTEQLATIAEKVNQRRQLLRYREARVRGLEATLRAERLGNVSSEDYITGLASCPLVKPVTTATRFDRVSPPAVVVVKLESALEKLTSALRYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RX37</accession>
    <name>A0A088RX37_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_302880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701311.1">
        <property type="nucleotide sequence ID" value="XM_010703009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RX37"/>
    <dbReference type="GeneID" id="22577341"/>
    <dbReference type="KEGG" id="lpan:LPMP_302880"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300033500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_302880"/>
    <dbReference type="eggNOG" id="ENOG502S6K0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271452at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO00511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="191" mass="21271" checksum="3CEB22A7105F77C2" modified="2014-11-26" version="1">MLISANSLVRWSLAAVGVSGAGLSGAYVYNTHFHQHPVRNDKIVQLAAIALSGEVVDKSLHDPEVLSQLRAFGLQVLTHPTVVAHLKKFFIHELTDDTPTRAALRSFVVREIIQDAWVKEELIGVAEDLVDSVKDNPDLFPDRILTWLGVGALEGLRAEEFWWALRHHTKTAGWIAFIGPPPFDMVFEAQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RX40</accession>
    <name>A0A088RX40_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heme-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_311100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701498.1">
        <property type="nucleotide sequence ID" value="XM_010703196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RX40"/>
    <dbReference type="GeneID" id="22577536"/>
    <dbReference type="KEGG" id="lpan:LPMP_311100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310017800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_311100"/>
    <dbReference type="eggNOG" id="ENOG502SNBJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="3">
        <location>
            <begin position="26"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO00698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="161" mass="17187" checksum="93914B9549A1A542" modified="2014-11-26" version="1">MPENVRYRFFFKGKSYLIPKGYIDHEHPGGGDEIMPYLGKDMTDAFEDADHSITAVEMLEEWLEEEYDPSIPSGPSGASSPSHEGAKTAESATEVSPLGAAFASAAPKPAPTVSTEPKTTTPRSASEPSKLKSLMPSVATAAAVAVLMASIALVYMRVPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RX43</accession>
    <name>A0A088RX43_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_281960</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700536.1">
        <property type="nucleotide sequence ID" value="XM_010702234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RX43"/>
    <dbReference type="GeneID" id="22576641"/>
    <dbReference type="KEGG" id="lpan:LPMP_281960"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280026100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_281960"/>
    <dbReference type="eggNOG" id="KOG0239">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972:SF28">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="7">
        <location>
            <begin position="473"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="391"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="159"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="421"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="534"/>
            <end position="541"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN99829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="811" mass="87811" checksum="9C2080CBBD4729C7" modified="2014-11-26" version="1">MLPSGRGRGATGLRSHVDHAITGATSLSTAGAKSGNAASPSDPPPTESERQLWATWREKRERLEREVQSLAQYSHKLTEETQAVQDAIEGMLTEFEDEKQRVEEHHNATVARYQGFMSALRVREEACLSARQRALDRICTSRETVSQLQREQAATQGAIISATDERDGLEQQLASANDAAAERTISLQQLQQEEDRMRDATYGLSGEVKELVLEMERLRKEKHRMDVESMETEVARRELYSLCEELKGSIRVYCRVKGAALPVEPQLPRDDTLCDEASEPQAIGLSKPEDIGTHLSESAEATAVASVEMPPLCRLLSRSGSLESSLSAAVLAVSSIPTTNTEAMVMTTDARHNTPGGGLRSGNSTTRSSVATASIMGDGEADAAADEGAAPVFSFPDQGEGDPLSDANHKAGQGGLPQVRGATPTGTTGSTTTTLAHAVTPLLCTSTAQGGEEEGGHFLTAAAVVGLPYGCGRCITIHQTRSNATSTGLSSFTETFTYDKVFTGEARQAEVYCDVEPLVRNAVDGYRVCIFAYGQTGSGKTFTMEGDVRGRPELYGVTPRALQTVLQRQAELANEGWSYELSCTFIEIYNDVIRDLFQSGSTRYEAAVQQQQQQAAMTASTTSSAVYHTIKHSGDRTYITNVVERNIRSMGEFLQLYKHAVLQRSTAKTGLNDASSRSHCIFTLHISGTNGTIRQRSDGVLCLVDLAGSERVNDSGVQGKQFKEAVNINRSLLDLGKCIRALRCGAVVPWRNCKLTYLLQNYLGAKGGKMLMIVTVSHAKAHALESLNSLRFAAQVQETYVGTSVKRVTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RX83</accession>
    <name>A0A088RX83_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histone acetyltransferase, putative</fullName>
            <ecNumber evidence="5">2.3.1.48</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_282410</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.48" evidence="5"/>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700581.1">
        <property type="nucleotide sequence ID" value="XM_010702279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RX83"/>
    <dbReference type="GeneID" id="22576686"/>
    <dbReference type="KEGG" id="lpan:LPMP_282410"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280030300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_282410"/>
    <dbReference type="eggNOG" id="KOG2747">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000193">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000195">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF214">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="4">
        <location>
            <begin position="46"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="396"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="399"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="416"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="429"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN99874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="573" mass="64325" checksum="1BCB377F1356CE5C" modified="2014-11-26" version="1">MVRLSHVLHRPWLSAVYGELTPGMARTQRARRQLDYLEERLLRDCRTPTTVRYFVYLNTYVFAPWYYAPFGLLNSEYDPMLPWTEAAGTSASASSASTPTGKGVHNTTGSSVEVQQQPFIRDAFLCPFSLRIYSTYAQMHYETRTYRADRLRPPGDEVYRDEMRGLFLFKINGSQHVTYCRHLFLIGKSFLENKLAGHDVHSYYFYVLCLHHRYFPHYVSDPSAMYFAGFFTWEKHVSEYNLACIVTLPCFGRRTSRQRSVAPQDGATATDSPPPQVLRHLGQFMIAVSYELAYRRKQIGTPEKPLSDLGAIAYQQFWRRAIVRWMKETLNAIRRATAVDVDADDMDKTVQKRAQGGAQVESRGSHASDTGVPLGLDAGSAAVEVVMLVEEGRGVTGGHDIDRGRSGEVDASLHERHSKALSSARKRSRVDAKTEHERNVDDDETRLTSTHGKLPLAAAVLPSLAKKGISGLSAAAQSPTGALLAAGTAAFTQRTTIRDIAVAVRLEEADVLKTLLGMGVLHRSGEDRGIQLLLPQRYVDWMYDETLRWESSLQHAVFQPALLKSRGFHTSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXV4</accession>
    <name>A0A088RXV4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Vacuolar protein sorting-associated protein 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_321120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the VPS29 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO00998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701798.1">
        <property type="nucleotide sequence ID" value="XM_010703496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXV4"/>
    <dbReference type="GeneID" id="22577853"/>
    <dbReference type="KEGG" id="lpan:LPMP_321120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320016500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_321120"/>
    <dbReference type="eggNOG" id="KOG3325">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10258130at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07394">
        <property type="entry name" value="MPP_Vps29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000015">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028661">
        <property type="entry name" value="Vps29"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN VPS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="6">
        <location>
            <begin position="4"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO00998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="204" mass="22103" checksum="0C988B8019018871" modified="2014-11-26" version="1">MVLVLAVGDTWVPQRSSGVPEVFSKMFSPGRIHTVLITGGVGSKGMYDYLRTIAPEVHCVESSVDRQWADHMSESVVLTVESLKIGLVRGNQVPLGDKESLAAIQRELDVDVLVSGSTHQPQYFEFDSHLFVNPGSLSGADTECEVNVVPSFMLLDVQDTSVVTFIYQYQPSDDSDGGGTASEGLATAGTVPGLRIKKKEWVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXX4</accession>
    <name>A0A088RXX4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thioredoxin-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_291720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00120.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700777.1">
        <property type="nucleotide sequence ID" value="XM_010702475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXX4"/>
    <dbReference type="GeneID" id="22576935"/>
    <dbReference type="KEGG" id="lpan:LPMP_291720"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290021400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_291720"/>
    <dbReference type="eggNOG" id="ENOG502SBGR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000516">
        <property type="entry name" value="Thioredoxin_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO00120.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="455" mass="47343" checksum="DD5EF8A00E1E6109" modified="2026-01-28" version="2">MYTTISSAFAAWATVGAHRGNWRTRVANSWIGTQSSSLYTPSSACLTLHPAVARTTRTAVCRRGGGAVLDVTASDMEVPRGQQLSVSVQRLLWGPKAPSPEKMMAVLTEQHMTGVASSVVATTRAASVATRMRRSAALDAVTASIEMLGDTGVAIPMGGAPQPTKRGSPAATSPNGGAASTGTARQNLGSSAATPTCDSSSAPLSSTETLVARPPARVFSFRGNPHELQDCLRGAKVLVFFYKTSCAPCTAIRSKLLRAVAGADVVGGGGATATPPTSTVFATEDSGIDGSSPPLSAPLQLYQNNRERPTRGLTTAPVAADTEATDAAAVVATTATMTVEEQKACNVACRFLGGVAKPFPHSVILLMVDTNANAEVTALHDIRSLPTFMAYRNGCIIGRFEGSHEDEIDKLVDLLTQDSTEGSPTTDNEKASQQQQQQKGTTSSPVPGDYDSHHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RY10</accession>
    <name>A0A088RY10_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="14">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LPMP_321680</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. PIF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="14"/>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701853.1">
        <property type="nucleotide sequence ID" value="XM_010703551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RY10"/>
    <dbReference type="GeneID" id="22577909"/>
    <dbReference type="KEGG" id="lpan:LPMP_321680"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320022400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_321680"/>
    <dbReference type="eggNOG" id="KOG0987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10050764at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF5">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 14 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="147"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AIO01053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="938" mass="103752" checksum="C62720DE286374D2" modified="2014-11-26" version="1">MLRRLTSRSGLQKKFNTVAAEYRKRSTAVISTAESVHWKNVLPLRRQHGAQRATRDPSTLRMLMSASSQRAVYNKHRNKHISESNRAQPTAKEEKEGCSTKDNVTAADDQAGFCGVSDVTLLPEAGKAATEFLLTREQATVCDLACEGASLFIGGEAGTGKSYLVRVIAERLAAQGLRIAITASTGIAALSIGGNTFHSTFGVPLHSPDNVINLSRRPPSTDPIFDIDDASKEGGDDGGAIEEDVAQADFATGPSVGKLGHPRRLQFRNTRVLAEVDVVIIDEISMLHAGVLESFERAVRRMAGRDSSRPFGGLQMILSGDFLQLTPFGSVDAPLGRRRRYRILDEKNKCMEDESSIVCQCVSPDVLDAQGTVDKAATTAELAVKSRDTSASSTSTEVESALAVKQDKRKRASSVSDSTITQHRYRDLWYYDKPMFESWCFVHHLLHVQLREQRRQQDQVFSSDLNRLRQGSFPYRLSRSAFLNAPAEDAVRLLPTKRAVKNYNDSKMLELEGDEQLFHTKLTMTEAMCASSAGTAQEQKRGDAHSGGNCEAVLLVHYRLCSPTEKGKAALKRRGQLRDAEATAVARNLEDVCRFPRNCLQVYGLPAPLSYSASLSAVCVRCSGATYRIAESRRFAVKRLLEMWSGVPGTGSSEATSGNAKDTKENTPSITLLQSRSALFPREVVRVEAVEARQLMRRLQPLIQEHLRNAIRKDTVLQDKRLKVGCRVMLLRNLTQQYVNGSLGRVVGFRPLSACTDLLPGEMKARATPMHLLAHFATCCPESGHGAVANAVQVPVVRMDTGGDDIAIPWITLPVSVAKQDWCFTLRATCIPLTPAYAFTVHKIQGVTLHHPVLFDAEGMFPCDHLVYVAASRVRKFEQLRMVNLSPRMISVHKPSLLFTQRIPSVEASVKRWALWKSKPRSEKFFYFPSHLTRESTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYI7</accession>
    <name>A0A088RYI7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA polymerase III epsilon subunit-like exonuclease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_322930</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701978.1">
        <property type="nucleotide sequence ID" value="XM_010703676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYI7"/>
    <dbReference type="GeneID" id="22578034"/>
    <dbReference type="KEGG" id="lpan:LPMP_322930"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320035700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_322930"/>
    <dbReference type="eggNOG" id="ENOG502SA7V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="242056at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06127">
        <property type="entry name" value="DEDDh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30231">
        <property type="entry name" value="DNA POLYMERASE III SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30231:SF4">
        <property type="entry name" value="PROTEIN NEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="4">
        <location>
            <begin position="51"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO01178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="292" mass="31281" checksum="8BAC3A4CE13338F0" modified="2014-11-26" version="1">MLPLLADTIGLLAPPQAGEKTPAPSHILHPLTPAVASASAASGCCCSAPLSCVVVDLETTGFSPTADEILEVGCVELRWTPSSRTTLTGPKDADPCAPPLEKQGSCGVLEGLWTRGGRVFHRYVRPSHPRCITAAATAVHGITWEKVQHCAPWPVVASELVAYMTLIRADALFTKSVQVEAAQHGGHSAVHLPPLVAHNALFDARFLAHHLQRCGYQIFWHPQYPLTCTRQWAQVAYPHLANNLDTLCAFLSIDGAADRATNGHGALTDATLTALLFLRMCCRWTERFGGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYL2</accession>
    <name>A0A088RYL2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Heat shock protein 33, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_301640</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701190.1">
        <property type="nucleotide sequence ID" value="XM_010702888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYL2"/>
    <dbReference type="GeneID" id="22577217"/>
    <dbReference type="KEGG" id="lpan:LPMP_301640"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300020700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_301640"/>
    <dbReference type="eggNOG" id="ENOG502RZ13">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="550012at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1280.10">
        <property type="entry name" value="HSP33 redox switch-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000397">
        <property type="entry name" value="Heat_shock_Hsp33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016154">
        <property type="entry name" value="Heat_shock_Hsp33_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016153">
        <property type="entry name" value="Heat_shock_Hsp33_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30111">
        <property type="entry name" value="33 KDA CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30111:SF1">
        <property type="entry name" value="33 KDA CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01430">
        <property type="entry name" value="HSP33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64397">
        <property type="entry name" value="Hsp33 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118352">
        <property type="entry name" value="HSP33 redox switch-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0346">Stress response</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO00390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="493" mass="53776" checksum="EACAFC8F2D0C8CA9" modified="2014-11-26" version="1">MRARAMLRCVARVVTPGAATGTSPTSSSPTPMSYSPVSVHSTRHALRTRDITLRVPSSDKLLRFSFCSTRHLLAETIRRHDLLRSTRAHLDFLQLLGTQLTFTNLLASALEGEERVEARFTAEEATILTEALALGECRCHLGPEYNAQLEARGLPTFPLRVNRVLYRQEKPFSSVVHADLAELLQTSSDTASNIAAAATRASEGSDIPLSLHLPNMTGRAPLEAWKSFFSYNSSLHAYNYLRRSDGSVSAVWMQSRIDAATLLAQGFLNADNTAAVSEWHHDEVCSDRDEEKKAQDVQRALRHAIPLSFGVMVTPLAAGGAVEHQVNQLTRVVMEAAALLCVPSDGETTVASPLQLLVDRCAERHTTCQHILSLVSGDYEGAYQVAVAARQYSDDPAQVAAVVDPIRRALGVQDFVTPLAATEVARTGIDFFCRCSKQQIIDSLASAPLSTLESLRESGHTVHCCFCGRQHKLADVECQVLKKTARSAITSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZF3</accession>
    <name>A0A088RZF3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Glucose transporter/membrane transporter D2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_330330</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702126.1">
        <property type="nucleotide sequence ID" value="XM_010703824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZF3"/>
    <dbReference type="GeneID" id="22578186"/>
    <dbReference type="KEGG" id="lpan:LPMP_330330"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000013200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_330330"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17315">
        <property type="entry name" value="MFS_GLUT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF8">
        <property type="entry name" value="FACILITATED GLUCOSE TRANSPORTER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="492"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="528"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="571"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="97"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIO01326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="617" mass="66886" checksum="242056038F61E6B8" modified="2014-11-26" version="1">MPFYFLEANTHVPVTTESMPTTSTDVSPTKQPCQEKPIIQGNAELPPLLVAADSPLVTPKQRASAPELPTSLDDDEEEYFSQPPSSTLFLSKKNLVVGIPIVLTPLLYGYNLGFVGPYSTIYEYASDCQLYKTEKSCETLTATKCRWFNASTYTGNTTYGEVCGWSDKTTCFLKYSDEASCLSDSVCKWSYSTNTCSNQVGFSSLQSGVFAGSLVIGSTVGALMGGYLTKRLDYRKSFLIIGIISIIGNALTHLATGLFHYWVLFVARIVLGFPLGWQSIASPHYTDKFAPADHAKTLGTLFQVSVSTGIFITSFFGLVLGNTIHYNTNRNANTMGRMQVLVTASTVLSIFVLFLPLITKDGYSKSKRADYEEEKDEDASRKATEKYTMMQMIGPILNGVAMGCVAQLTGINANMNFAPTIMSNLGLQPLVGNIIVMAWNMLATFCVIPLSRRFSMRTLFLFCGFVGSLCCVFLGGIPVYPGVTKSDEAVSGIAITGIAIFIALYEMGVGPCFYVLAVDVFPESFRPIGSSITVGVMFIFNLIINICYPIATEGISGGPSGNQNRGQAVAFIFFGCIGVVACVIEYFFLQPWGEPGAKMADNFDGVAIREGDTTGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZK0</accession>
    <name>A0A088RZK0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tim10-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_330930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702186.1">
        <property type="nucleotide sequence ID" value="XM_010703884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZK0"/>
    <dbReference type="GeneID" id="22578246"/>
    <dbReference type="KEGG" id="lpan:LPMP_330930"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330013900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_330930"/>
    <dbReference type="eggNOG" id="ENOG502S6PX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270202at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO01386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="114" mass="13071" checksum="7A67368E06B8D65B" modified="2014-11-26" version="1">MQSPPPPMTPYEENITRSYQYLNGVRMQSAILFSSTTFCIDRCLDTEELYTLMRTTNAPISYRLQKDMEEKKCVQNCSAKWDELFNLTLTETNEAAIRDVQASAIAKMMGAIQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZL4</accession>
    <name>A0A088RZL4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_331090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702201.1">
        <property type="nucleotide sequence ID" value="XM_010703899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZL4"/>
    <dbReference type="GeneID" id="22578262"/>
    <dbReference type="KEGG" id="lpan:LPMP_331090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330016000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_331090"/>
    <dbReference type="eggNOG" id="ENOG502S33S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273262at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="455" mass="49647" checksum="EBDFC746B1F9AEE8" modified="2014-11-26" version="1">MYVRAQTRRGEPKGKKEAQPTMDGGDSVFYEDAVLCSDEGEVKDDTPQATLKLLADFPEPLTEPQRRAVQRYVSQKVREYEVVRYQVAVVEKGYLALLRLVKRLRREVAELTASLIEGVNTSDASTPTAAASVSISPAAPTAATSAVSATKEGTIAAKRRSVGLLLRSSVFSSLQRVLQAVQTEQLDEKAEQLARQRERIARESRLHLVSQDLVSQEALLEPLQRKYARAVALGAAAAEEVTPLLTLLEDMWRLEALYPSRFSMVARGTLQLLLGDGTHEGEGNRAEEEVLVDPDDDSSRTAARSAAAVSFLVPFTPAQYTPDIEDLVRAQVEVVIDEYLAYRTRMDPVLYQLEQSQQLAKAKKVDQLMDAIGIAGTESGIEVLPMGSAAAVLHDERGGVLVKTPQHMMDISSDDEDDDQAHAGVTIGGGAADADCHDRKQIQTALTALDDFEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZQ2</accession>
    <name>A0A088RZQ2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Centrosomal protein 20</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">FGFR1OP N-terminal-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">LisH domain-containing protein FOPNL</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LPMP_331980</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the biogenesis of cilia. Required for the recruitment of PLK1 to centrosomes and S phase progression.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Microtubule organizing center</location>
            <location evidence="3">Centrosome</location>
            <location evidence="3">Centriolar satellite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic granule</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CEP43 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702289.1">
        <property type="nucleotide sequence ID" value="XM_010703987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZQ2"/>
    <dbReference type="GeneID" id="22578351"/>
    <dbReference type="KEGG" id="lpan:LPMP_331980"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330026900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_331980"/>
    <dbReference type="eggNOG" id="ENOG502S0C1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5970631at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034453">
        <property type="term" value="P:microtubule anchoring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.960.40:FF:000002">
        <property type="entry name" value="LisH domain-containing protein FOPNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018993">
        <property type="entry name" value="FOP_dimerisation-dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15431">
        <property type="entry name" value="FGFR1 ONCOGENE PARTNER/LISH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15431:SF4">
        <property type="entry name" value="PROTEIN TONNEAU 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09398">
        <property type="entry name" value="FOP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGFR1 oncogene partner (FOP) N-terminal dimerisation" evidence="13">
        <location>
            <begin position="59"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00076755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00081996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIO01489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="127" mass="13914" checksum="40C33540D74D545B" modified="2014-11-26" version="1">MSNKESLKAAMRESLEANGTISHIKAELRAAIFERLSDVTTSGDGRNVVNPPVPPENMVINELIKEYLTFNGLEHTLAVFQLEARSPDSQVPRRVLASELNMAAAPSSVPLLYAMLHEARLSKDMGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S029</accession>
    <name>A0A088S029_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dolichyl-diphosphooligosaccharide--protein glycotransferase</fullName>
            <ecNumber evidence="6">2.4.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LPMP_341040</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a di-trans,poly-cis-dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = N(4)-(oligosaccharide-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + a di-trans,poly-cis-dolichyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22980"/>
            <dbReference type="Rhea" id="RHEA-COMP:12804"/>
            <dbReference type="Rhea" id="RHEA-COMP:12805"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="Rhea" id="RHEA-COMP:19509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50347"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57570"/>
            <dbReference type="ChEBI" id="CHEBI:132529"/>
            <dbReference type="EC" id="2.4.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endomembrane system</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.18" evidence="6"/>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01728.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702528.1">
        <property type="nucleotide sequence ID" value="XM_010704226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S029"/>
    <dbReference type="GeneID" id="22578608"/>
    <dbReference type="KEGG" id="lpan:LPMP_341040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270009800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_341040"/>
    <dbReference type="eggNOG" id="KOG2292">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261066at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004579">
        <property type="term" value="F:dolichyl-diphosphooligosaccharide-protein glycotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048307">
        <property type="entry name" value="STT3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02516">
        <property type="entry name" value="STT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AIO01728.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="776" mass="86470" checksum="BF562F51D144F87A" modified="2026-01-28" version="2">MLSVQTYGYIIHEFDPWFNYRAAEYMSAHGWSAFFSWFDYMSWYPLGRPVGTTTYPGLQLTAVAIHRALAAAGVPMSLNNVCVLIPAWFGAIATTILALMAFETTGSIAVSAWAALLFSISPAHLMRSMAGEFDNECIAVAAMLLTFYLWVRSLRTRCSWPIGILTGIAYGYMVAAWGGYIFVLNMVAMHAGISSMVDWARNTYNPSLLRAYALFYVVGTAIATRVPPVGMSPFRSLEQLGALVVLLFLCGLQACEVFRARADVEVRSRANFKIRMRAFSVMAGVGALAIAVLAPTGYFGPLTARVRALFMEHTRTGNPLVDSVAEHNPADALAYLQYLNIVYILWVFSIPVQLILPTPNLYAILFLLVYSCMAYYFSTRMVRLLLLAGPVACLGGSLMSGTLTKWCFQQLFWDDNLRTADMAAAGDTPFSQEDHPNSGARARRNQQKQKATQASARGSSTGDEERRYTSLIPFNFRKEIKMNRWPTGKKQATLIISATICTVLPLAFVYYFSCTSMANSLSSPQLLFQARMRGKTIMVADYLESYEWLRDNTPADARVLSWWDYGYQITGIGNRTSLADGNTWNHEHIATIGKMLTSPVAEAHSLVRHMADYVLIWAGQGGDLMKSPHMARIGNSVYHNICPNDPLCQHFGFYNEDYSHPKPMMRASLLYNLHEAGRSAGVKVDPSLFQEVYSSKYGLVRIFKVMSVSEASKKWVADPANRVCHPPGSWICPGQYPPAKEIQEMLAHRVPFDQMGKKHDDTNKARMARSRTPGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S093</accession>
    <name>A0A088S093_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RanBP2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_333330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702421.1">
        <property type="nucleotide sequence ID" value="XM_010704119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S093"/>
    <dbReference type="GeneID" id="22578486"/>
    <dbReference type="KEGG" id="lpan:LPMP_333330"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330041700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_333330"/>
    <dbReference type="eggNOG" id="KOG4198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="448399at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23111:SF40">
        <property type="entry name" value="RNA-BINDING PROTEIN INVOLVED IN HETEROCHROMATIN ASSEMBLY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23111">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="5">
        <location>
            <begin position="100"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="5">
        <location>
            <begin position="186"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="5">
        <location>
            <begin position="228"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO01621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="305" mass="33243" checksum="969CDF4147B0F17E" modified="2014-11-26" version="1">MLKLRGLVRVKTGAAERYLLPVCLTAQCYTASAPGKWKCACGLHNFDFHSECYSCHEKRTDTPTAKTVSPLSLLGDVQLEDGDFAEVHSSSTERDKVHSVEGVWICPACYTVNGSQRVACTYCREMRPLLQPRGAAGTPMDTHARRFGKVAVASSPPPTVSSSAVAAMTDFSSELSDDFVPQQPFKKGDWYCACGVHNFSRNMHCRKCHEPRTPSSSATPKEGLLVSRPGDWECLKCKMYNFSWRTVCKRCNEAQPLPNAAPFSAPPDSDVPTGMAAGWVCQACHSLNPADDAVLCVICGSPKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0D1</accession>
    <name>A0A088S0D1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_342370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702663.1">
        <property type="nucleotide sequence ID" value="XM_010704361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0D1"/>
    <dbReference type="GeneID" id="22578742"/>
    <dbReference type="KEGG" id="lpan:LPMP_342370"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340029700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_342370"/>
    <dbReference type="eggNOG" id="KOG0800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042862">
        <property type="entry name" value="RNF32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14991">
        <property type="entry name" value="RING FINGER PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14991:SF0">
        <property type="entry name" value="RING FINGER PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="396" mass="42997" checksum="3FAFB98766CAAACA" modified="2014-11-26" version="1">MCYSAKGDEGQVILSCSHVFHTQCFRSFERYVRAQQRADALGVAVATAPLACPVCRTQNYHKRIFYEGKAVAQRAAIVKVQAAVRGLLARRAYTKLRLKNNREFRTHYVQERLARLSAAWEAFCAQQERSRVAVEAALAVQHQAARAACLTEEAWAELWRKTVHDPSASSESGSLAAPATAGVSVQCPICLELIYCSHWPGTRAASFHAGGVRKSTGEDAVAAMRMAYESRQAAKRVQPLELKAIRKSTGMPMGGAVKGAVSRKVSNPSTADPGATGLVRGWKVVSRRVTQHQAGHQKGSAQWAAAAPRPEHETAFTVLSSAKVVDADSANKAASILPQSGVLLSCGHYFHAACIKCYEQFNERGSLRVDKQPGQVVAIVLNRCPICRSGYAKHPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0W0</accession>
    <name>A0A088S0W0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_344210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702843.1">
        <property type="nucleotide sequence ID" value="XM_010704541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0W0"/>
    <dbReference type="GeneID" id="22578926"/>
    <dbReference type="KEGG" id="lpan:LPMP_344210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340049600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_344210"/>
    <dbReference type="eggNOG" id="ENOG502QU19">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="246467at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="342" mass="39725" checksum="04459E7F642AC1BC" modified="2014-11-26" version="1">MLRRTCFARVHLFSALVPQVKVQAPHFLSLEDLATAKAALEERKPYIDYPELVQCIEALGNIDNARKKSDVTKKLSRCVDALRAQLYHKDSTDPRRRLELHEAVMAAGFYERVISVTQLEGEGIRYVMNHFNFDVRRDTLITQKVHEALSKEKTTTPESEQLLRDLLLLERRLTGKYRFSQFGGRRWFALGTPLSEIKTEEEVQRLLGISVIKSDGNFTLGEVDSGKLWKTITIRPNEEQNATFAEVGNIFKDTRETDTTFELRVQKPQKPPDFWERLRETLLRYWVLWFAVWVTFFMVDEEIITLVALIFLKHRQTKILEEEAQKSGSKVYIASSVGRSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S169</accession>
    <name>A0A088S169_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_020210</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP009371">
        <property type="protein sequence ID" value="AIN95201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698166.1">
        <property type="nucleotide sequence ID" value="XM_010699864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S169"/>
    <dbReference type="GeneID" id="22571831"/>
    <dbReference type="KEGG" id="lpan:LPMP_020210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_020007500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_020210"/>
    <dbReference type="eggNOG" id="KOG0589">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="149"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN95201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="529" mass="56035" checksum="2BE41321E1CA2BD4" modified="2014-11-26" version="1">MGERFEWMEFGDNVSGSQARGRKTNLISAEEDVPIFLREDAGTGRAGTSHGTAAPGSADLDARDGTPAFLLGYPAAGESPSLGGGFTSAGSPMRDGTPQQRLFASPAALGHSGGAGQVPATSSAALYADQPSAAVLQFIGDSGRTWGGLHRVRILGKGNYGCATLYSMKDDFSGGVSPTHAVVVKDINMQTMLNPSEEILAVRNELKVLRTVLGHPNLVQFVDAMFDARPPNCPVSFIMMEYCAGGDLAAVMAGCSGGSVASDEALSSPVSTPQCATTAATVAGLGHLTEPHVTSLFIQVAVALQSLHTEYGILHRDVKPHNIFLLEDGMTVRLGDFGISTQLDRVGDRAKEACGSPYYMAPELLEERAYGAAADVWSLGVVFYQLMARQLPFTATSAAELRSLVCRGRCTPLHELHNEATSRYSQQFRELVSSLLTVDAAARPTLRRVLRHKHVRECLKYVPVSVLTAKKPQPPARVSCSSAMPSSLPRPLSADGLYAGVFGADAVERAVSHAVHAGVHPIVNRVHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1K2</accession>
    <name>A0A088S1K2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GTP-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_345050</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702924.1">
        <property type="nucleotide sequence ID" value="XM_010704622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1K2"/>
    <dbReference type="GeneID" id="22579010"/>
    <dbReference type="KEGG" id="lpan:LPMP_345050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340058600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_345050"/>
    <dbReference type="eggNOG" id="KOG2485">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269151at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01856">
        <property type="entry name" value="YlqF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782:SF4">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="4">
        <location>
            <begin position="168"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="360"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO02124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="464" mass="51530" checksum="03DAC55EE9D0A90F" modified="2014-11-26" version="1">MRTTVRQCNVFDPAFMRKVKRTLNAYKSSMETSTKKCMSREAFVDIDEKGAAWYLGHMQSAVTMLADKVKDADFILEIRDARLPFTTENPNIRKLTARKPRLIIFNKAELSNEDSNRAIQEYYERNGAFALFTSAQRCWKDVMEAVQRFTTHILPPLPYKTVAHVGLVVGMPNVGKSTLINSLRLAHEYQFHREDFRRSRSPETVSIKPGTTRGMKLVPLSKDPPVVLYDTPGLTLPGCFTKESGLKLAACSIIPTNDVSLPQGMVARYIYDILVASGSSEHMAECLHLPRVPITFDDCIAMICERSGTSGQTEMGNLDPVRAHRFFVHDFTMGNLGKITLDVLPRRVLRSAQSSLPLLASGGSTATSDGGPAAGSDDDGYVWTHHVESSDVVERYPDHMHDVLQSLKGPLHYDGMPGRHGASSVRSVASPPDCIIISRKKGPISRATAFDEQLKRHTRLAPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1Z7</accession>
    <name>A0A088S1Z7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_050640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="AIN95506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703828.1">
        <property type="nucleotide sequence ID" value="XM_010705526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1Z7"/>
    <dbReference type="GeneID" id="22572142"/>
    <dbReference type="KEGG" id="lpan:LPMP_050640"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230027300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_050640"/>
    <dbReference type="eggNOG" id="ENOG502RZ0D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="41362at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="entry name" value="NADH Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050461">
        <property type="entry name" value="Nitroreductase_HadB/RutE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43543">
        <property type="entry name" value="MALONIC SEMIALDEHYDE REDUCTASE RUTE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43543:SF1">
        <property type="entry name" value="MALONIC SEMIALDEHYDE REDUCTASE RUTE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="FMN-dependent nitroreductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="68"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="298" mass="32081" checksum="AB5EE5142345D9BC" modified="2014-11-26" version="1">MFRHSRCSNKARNGTSSGSSGFLATLRSLVTWGRASATVASSSSPASCGRTAGCISAGVALDAVEAAVRNRWTCRQFDTAKTIDLDTLRRVLTATTRAPTGFNLQGWHAVVVTSTAVREQLVKAALGQPQVLQAPATVVFVGDMEPERNAPQALEMGLETGYYDPLYGSAYLRNVYYFLHGGPMQSMAAVKSAVSAWYSRAAGTPLVSVPVSRAGYAWKQTLIPATTFVQLCTAAGWDTCMMEGIDEEAVKQVLGVPTERYTVPVIVSVGYATAAEAEKRQVRSPRFATPHTVRWNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S204</accession>
    <name>A0A088S204_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_350840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703021.1">
        <property type="nucleotide sequence ID" value="XM_010704719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S204"/>
    <dbReference type="GeneID" id="22579113"/>
    <dbReference type="KEGG" id="lpan:LPMP_350840"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350014100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_350840"/>
    <dbReference type="eggNOG" id="ENOG502QSCD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268671at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO02221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="459" mass="52191" checksum="60D68DF77983C65B" modified="2014-11-26" version="1">MMRRGAPKWFTQGKGRERFHRYWPWAVSSICTSLYLYNGEPFEDAASAIVTTIRRPLLKTMEWVELHDVDPETMSLELPPDMLFGPLEFPKQMRFLLAALRADNELADGYLARIIIDYMDLSLDPPILSEDDFLAAGGKALLDFSVEDFTGTESRTQRKHIFFQSDQFLQFINIIAAYPSLTEYFVNEKDGVELVLQAYRHSKNPYARVMAMRSLTLFSFTQAVDGTVERRILQSNGMKTIVEAYRQSSGDPTDTRFPTLLLSSIMRHYPKEGGKEFIDANGVEAVVNNLTIARYKGIPQHIRVLHDAQRLPKQSVGKKSVTARLEDADFLGVAMGVLDTFPEFYEATGELLRLVTDVVPAHADPLDLLEYRAMPILSKYFVKWREDQSFQTDGTRTLVAKLFELMLNDKTCQRCYDPSVASYELLECLKTAKLAVKDEREKRGTLCSDQPQQPASATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S277</accession>
    <name>A0A088S277_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trm112p-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_060150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRM112 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703898.1">
        <property type="nucleotide sequence ID" value="XM_010705596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S277"/>
    <dbReference type="GeneID" id="22572221"/>
    <dbReference type="KEGG" id="lpan:LPMP_060150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060006800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_060150"/>
    <dbReference type="eggNOG" id="KOG1088">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2187549at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039127">
        <property type="entry name" value="Trm112"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12773:SF0">
        <property type="entry name" value="MULTIFUNCTIONAL METHYLTRANSFERASE SUBUNIT TRM112-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12773">
        <property type="entry name" value="UPF0315 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="141" mass="15928" checksum="CEDF4087C24AEA21" modified="2014-11-26" version="1">MRLLTHNFLACLQCDTYPLLVSAAEMEEIPVEYDAEFTRRMLARIDYPSLRTTFHTLREAHKSVRGPSYDEDPDATETAAACAELPETMEGADLSDDSAFLRMVHYAMNIVAVRNGTLECPACKTTFAIRDFIPNFVQETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S279</accession>
    <name>A0A088S279_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_352220</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703159.1">
        <property type="nucleotide sequence ID" value="XM_010704857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S279"/>
    <dbReference type="GeneID" id="22579251"/>
    <dbReference type="KEGG" id="lpan:LPMP_352220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350028300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_352220"/>
    <dbReference type="eggNOG" id="KOG0331">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17966">
        <property type="entry name" value="DEADc_DDX5_DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="134"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="320"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="505"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="551"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIO02359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="570" mass="62965" checksum="8BA2032C337CC7C8" modified="2014-11-26" version="1">MAERNYSPFSGFTTTSRGGGAHRKDNSGAMGSKLAPVNWSTKSLVPGKWKVVDASAIRKAASIKDNHGANKVTHLSDGEADEWRQANSITVSDSDQCPNPITQFDMLTTVPQYLKAKLLAQGFKAPTPIQAQSWSIVLSGRDLVGVAKTGSGKTLAFIVPALAHIALQEPLKMGDGPMVIVLAPTRELAQQIEQETIKVLPQSIRCGCIYGGAPKGPQLGLLRQGVHILVATPGRLIDFMEIKRVNLLRVTYLVLDEADRMLDMGFEPQVRAICGQIRPDRQTLMFSATWPRDIQNLAASFQKNWVRINVGSMELLANKDVTQHFILTSEAAKLDELKRLMERHRNQRVLVFCKTKKTADYLEFQLKRNGVDCMAIHGDKEQRQREFILERFRKDSRLCVVATDVAARGLDIKELETVVNYDFPMQIDDYVHRIGRTGRAGAKGASFTMITKHETQLNASTVFQLVELVERAGQEAPGWLREWAEQGGGYHVPKRNRNMMGSFGRSSPRMRMPGDHSAAGDGSGGGHFGLAPHAKGSPAFGMKGGAIENKKFDYSSEDDDSAQPVKRTRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2D6</accession>
    <name>A0A088S2D6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vacuolar ATP synthase subunit d, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_340630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702490.1">
        <property type="nucleotide sequence ID" value="XM_010704188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2D6"/>
    <dbReference type="GeneID" id="22578567"/>
    <dbReference type="KEGG" id="lpan:LPMP_340630"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340011800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_340630"/>
    <dbReference type="eggNOG" id="KOG1647">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7676488at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3240:FF:000015">
        <property type="entry name" value="Vacuolar ATP synthase subunit d, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00271">
        <property type="entry name" value="ATP_synth_D_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11671">
        <property type="entry name" value="V-TYPE ATP SYNTHASE SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO01690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="264" mass="29350" checksum="061355A9B3628ACE" modified="2014-11-26" version="1">MSSTNRYPALPSRMTLIAFKTRLKGAQKGHSLLKKKADALALRYRIVMGELHSAKLDMANQIKGSYFTITQAQFIAGDISLAVQESLKIPTYRMELQVENIAGVQVPSFHTQNGDAAEGQRTATVAAAGSLTTGLGKGGEQIKEAYFAFRQTLSLLVKIASLQTSWITLDIAQRVTNRRVNALEKVVIPRLQNTLSYITSELDEQEREEFFRLKMVQKKKKAMAKIQQAARDAETVALAEERTRQRNLLMAQYDGGVVEADMVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2H8</accession>
    <name>A0A088S2H8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Peroxisome targeting signal 1 receptor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PEX5</name>
        <name evidence="10" type="ORF">LPMP_341290</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peroxisomal targeting signal receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702555.1">
        <property type="nucleotide sequence ID" value="XM_010704253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2H8"/>
    <dbReference type="GeneID" id="22578634"/>
    <dbReference type="KEGG" id="lpan:LPMP_341290"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340018900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_341290"/>
    <dbReference type="eggNOG" id="KOG1125">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10006023at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005052">
        <property type="term" value="F:peroxisome matrix targeting signal-1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000110">
        <property type="entry name" value="Peroxisome biogenesis protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024111">
        <property type="entry name" value="PEX5/PEX5L"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="10" id="KW-0675">Receptor</keyword>
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    <keyword evidence="6 8" id="KW-0802">TPR repeat</keyword>
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            <begin position="478"/>
            <end position="511"/>
        </location>
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            <begin position="512"/>
            <end position="545"/>
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            <begin position="290"/>
            <end position="317"/>
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    </feature>
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            <dbReference type="ARBA" id="ARBA00004275"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="632" mass="70744" checksum="E3F924280BE69F2F" modified="2014-11-26" version="1">MDCNTGMQLGQQLAKDTMMSHGGVPMSGIMSEQDALMPNVQVACTNPMMEAQWAQNFQQQQAMQAMRQQHEMEQAFQNSQQQQVAVVQGGQMLGMARPSLPQLMTQQQQQASMMNAAMMSQGMMAANMGFGMMMPRTQYQPLSNLSALQPKQQQQQQQQQTLVNLAPAAQDSAWADQLSQQQWNTDYSQVQVFGTAGTESKTAEERIKDSEFYKFMDQIKNKEVLIDEEKGELVPGPGPEVVVPEDTEYLRDWAAMEGMNMPESVFQPLPSSSAMTPPANRDPDSYVEEMDMAENDVEDWAQEYAEMQERLQKVTNSTDYPFEPNNPYMFHDLPYEEGMEMLQLGNLAEAALAFEAVCHKDSSNEKAWQVLGTTQAENEKDGLAIIALNNARQLNPRNLEVHAALSVSHTNERNTDAAMDSLKAWLVQHPEYEQLASVSIPPNPDLDVQDTFFFADPSRMREVRTLYDAAIEMNPSDSQLFTNLGVLHNVAHEFDEAAECFRKAVALHPADPKLWNKLGATLANGGHPDQALEAYNHALDINPGYVRAMYNMAVAYSNMSQYNMAARQIVKAIASQQGGTNPSGEGSILATRSMWDLLRMTLNLMDRDDLVQLTYTENLEPFVKEFGLEAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2K2</accession>
    <name>A0A088S2K2_LEIPA</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">LPMP_061070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
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            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
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            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_010705686.1"/>
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        <property type="component" value="Chromosome 6"/>
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        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:cilium assembly"/>
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        <property type="entry name" value="PROGESTERONE IMMUNOMODULATORY BINDING FACTOR 1"/>
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    </dbReference>
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        <property type="entry name" value="PROGESTERONE-INDUCED BLOCKING FACTOR 1"/>
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    </dbReference>
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            <begin position="1"/>
            <end position="21"/>
        </location>
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        <location>
            <begin position="33"/>
            <end position="62"/>
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            <begin position="529"/>
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    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="614" mass="68330" checksum="86094D95E2BA3177" modified="2014-11-26" version="1">MPLGRMQVRRPPRRVEVPEDDGGLAAAAVVGATASAPATTASSRSHSPTATTTSTASSSSSALLHRHTFIQQVRRYEDENIRALLHQLPSSPKQLMRRLEQCQQEMNLLKEENILLKSREVEISSLTLRLQERINATQSQVDHIKAQVHLQLSNPITEEEYQRIEALTEAQRDLVDVMKLGIYRQLGSLRASQQAATKRAADLSTSLAQLQQENSDMKVRLAEYESQGEAEKEKADKKARQIASQQARIAELEGHITSLEAKGKSMYVDQEQYLSAKLTAQIKTDEVARLSVRLEESEMDTQRYRANAECTEQKLDILKSEYYELKLRYGQRVLELESALKASEEKLKTLGDLEMESQLFISNLAVSSQGEVAFGTDSAVTATGRPADAYEGWLALPRSRKLAHTLVITKRCLHLENKVAALEHDLAFKEAQMARLQVALDGARDALHNINSPYVLVEKAMAELTDENEALKQKVSILEQDKKDLQLKVQQYSSNLRVLTYHRGELLRMKKMLRQLGLREGFVFPAGDEEAEEVEGPPLRQPSEAGRKQTIRVVGASGGNVASPTQRKGSMTSLASAVARRIDGVEADSSEMHQIPGNTPPASFGSLRPIEMTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2K4</accession>
    <name>A0A088S2K4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_341630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AIO01790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_010704288.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="22578668"/>
    <dbReference type="KEGG" id="lpan:LPMP_341630"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340022200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_341630"/>
    <dbReference type="eggNOG" id="ENOG502RY7C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269645at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="162"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="210" mass="23762" checksum="4E89EECDD27A1477" modified="2014-11-26" version="1">MKKSVHLWQGIQPELHRYSHATFHEGTHRQAPGDSTPWRDVSSPVNRFRAWWLAPAAKGSVIAAWSLTCVIGAYCFSIQQDAKGTYLLNNVLLRNLHEESQRASANEERADALQEAMRQYLAEGTSRKQNTANLAEYVASSEKMKAGIVNYELELVRERGRADATHERNQKLVKELLAARQEVARVQKDNATLVGEVEKLQRLLKRSGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2L7</accession>
    <name>A0A088S2L7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_353630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_010704997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2L7"/>
    <dbReference type="GeneID" id="22579391"/>
    <dbReference type="KEGG" id="lpan:LPMP_353630"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350044300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_353630"/>
    <dbReference type="eggNOG" id="ENOG502S8EA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="251490at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057418">
        <property type="entry name" value="PH-like_kinetoplastida"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25402">
        <property type="entry name" value="PH_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH-like" evidence="2">
        <location>
            <begin position="1011"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="290"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="763"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="872"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="922"/>
            <end position="1001"/>
        </location>
    </feature>
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        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
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        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="376"/>
        </location>
    </feature>
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        <location>
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            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="781"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="883"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="928"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="939"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="988"/>
            <end position="1001"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO02499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1151" mass="123818" checksum="F691D69677F5396E" modified="2014-11-26" version="1">MQAQSRVSEHLPTSFLSSPSSSVACESTCSLDALERLVNFTGAGADACLYGVNPPQVEGATSAALTASAEGLRYWLNPSVRARQTTATCEITNLGPPFFAATSTSVLRISATPLFVDGRCFPTRCVVSLATSAQRLDGVSLRPVVVTEWNLTLNGAVSVCSTTVPLRTLYHLVVLISSPAPATDVEDVRLYLQLRFMGCSDDSDTHRIAALRLRYEQLGPAAEVLPQLLQRRQRSAVRMMLPPSSHDVTDYSGDRVSRARALREEMEVGVATSSRTCRSSGKDVVEGVREEHFSDAKVPCTPTSPLPSTRVMSDGSEDATGQAQKQLLRSPPRRSATMPRAERSLSADRSSSSWMGAVGTTEDRDGPRLIRVDRVLRIPPPPPKPTTAAGSAPSLFGSPWPPRKVRTIVLAPSISPSLCSSSAGTSSRGSSSPSPPSRPVMDTCSSTESHSPTSLTSTPRCRGAESRDREGIEDVGDSLMPPAQQNLQGRFLESTKSEERTSSPASVVGPSSQRRRYHESSSVLRHISAEAQEVAKNNPDTHPHLFAPQQLCSRSDPAVLWAATSLLGTLPCALVRGYQSRSSTPAASVASSCAPSCNRSARAMSADSGKEASFWQMRQSAPSRSFLDSSACAHHRDTRQTPQQKEMSWRRTPLSALDPNTSSRCTERTVMSRADSAAMTWTCSAKATTAFLPRWRRDEGTHVSPQLHPPRPFATASPSHSHPTPLSGPSLPLQAVTHVPLHRPTSAFVPRLLLHSKQRSREAYAASSTQRGEGMITINRSSTTSSSTVSTTTATSAPPPYQNRSLWSKAAAPVSATSPLNAGPRRSATADSHVRRCVDRDAFSMSSAALSLMPSSWLRDNANVLLETSTDGAAEKNLRGPVASRRSSRSSTAPPPSRRAHHVPSLTRAAVSEHLEDALSVVSGSSAPLPPPSVPPPQSCALFQTPASTQASPLPSPSSSNSRSDTAPVLPLQEAHHRSRNRNDPRQRNLTQSGGVHSSSNATTYGHWVVETFAVWKHHASRRGVGRRWLRIEWPSPSPSTSAATRFRIALDKVHPSMLTRASVLLGHGTNSSGNSSTRTANPSCEVCIRQADTLEVWCGLRAYHCGMIHQSKVHRSECCLVIRCNAQLVTAVELESTEALEAVQRLLSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S388</accession>
    <name>A0A088S388_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_090350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN95951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704273.1">
        <property type="nucleotide sequence ID" value="XM_010705971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S388"/>
    <dbReference type="GeneID" id="22572605"/>
    <dbReference type="KEGG" id="lpan:LPMP_090350"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090008500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_090350"/>
    <dbReference type="eggNOG" id="ENOG502RSIV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PRAJA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="749"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="302"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="390"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="767"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="400"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN95951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="856" mass="87310" checksum="AD3F995E43DC20F5" modified="2014-11-26" version="1">MKSVIKVFRELEATSQLPPTTPQQHIAPPTVLLPATLGMVPPELAAMAAMAGPACTGGVGGMMPPLSPSVTNNTAAMSPQASIQMCMAPALALSPFPRSPMLMDSTKVQDTDDGCSVSKPPIWPPPQSPYTALRMDGGSDPSDRSSTVHARIAPAVGSLDDDSAYGPLTSASSIEATRLSHSTLESSLEVNTSANQFNAEDVTPSTTNTITTGCGSWRRSHSDARLDKARCCSPISLCPHAQAHHEPCPACEASLTCGGAVASRVGCMDHHPPLFPAFSESVCAFYPLTNVKEPTSASAAAPAISSRSASHEQVSSGRPSIAPKNAAPHQALEEPQPTPQSPLSTTTDTVSATPRSKAPVGLALQENTMITILDTLSGADCTTSSTLCAAPTPPPLRSGSLPSQSTSTVDAKPNSVSNRRGSSTPAAAAAIAMATAVASRRRVPLPASSATTMPPPPPPYMRLSYASNVNNAHGSPSSTCTSAMLGAIALVPIGMQPAIATAASSFFAATACQSPAYAAVSTSDPPTSSSGVATAPPLPASDLGLSAASTVLSMSSVPTLAALDTPGQEFADARTPTTSPLRPAYWAFPCAPTGSMTVILAAPEVSWHSLTSRVMTPPASSAGAAISDSCSQNCIGDCCVHGAGTPFMDRCSSSASMATPRAVSPGTLTALPASSVRLESQRASGSRGAMWTSAGQTYRNVLVHGGRGSGSIAAVTASGSGYSLGLPLYSSQPQLLCTPVPLDDTESVCAICLEGRASKTHTTEINEASAPLQPSRAAEGGSSQKNDSAAAVISNTATVADEGAEQGAVRGVKPGSCLLSLPCGHCYHQNCVQRWLIESQSCPTCRRDLTRDATLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3D8</accession>
    <name>A0A088S3D8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_344910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702910.1">
        <property type="nucleotide sequence ID" value="XM_010704608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3D8"/>
    <dbReference type="GeneID" id="22578996"/>
    <dbReference type="KEGG" id="lpan:LPMP_344910"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340057000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_344910"/>
    <dbReference type="eggNOG" id="ENOG502SDYZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="260465at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO02110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="171" mass="19444" checksum="6187D4B2C333D6AA" modified="2014-11-26" version="1">MSLFERPHRLTSVSSVVMGLNPATLREIDDYAMWMDEVHAELAGVYGEQAMQWKVSDITYATSDNPSRFSSRITQGLFESLHDYKALLEKIDAITTQLTEKTQLQELIETAISQDTEGGKSLRKQKRELRSLKANIIQLTRQGAELKYQLVCLSQQLSHVFKAKVVRISLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3J9</accession>
    <name>A0A088S3J9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_356960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIM50 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703624.1">
        <property type="nucleotide sequence ID" value="XM_010705322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3J9"/>
    <dbReference type="GeneID" id="22579724"/>
    <dbReference type="KEGG" id="lpan:LPMP_356960"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350079400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_356960"/>
    <dbReference type="eggNOG" id="KOG1605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000171">
        <property type="entry name" value="Nuclear lim interactor-interacting factor,putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FCP1 homology" evidence="3">
        <location>
            <begin position="55"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="263"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO02824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="292" mass="32903" checksum="031B729AAF967816" modified="2014-11-26" version="1">MPSQRRRGASFRGVYCPDAFSVCLEDSVTETAEVFRRSPSITARGEYLVPAKPSEIKNRLTVVLDLDETLIYARQGPLYVRPGMETLMRFLADYCETIVWTSSKHRYADAVVAQIDTCGAVCHTVYRHRRWFNGTSATKELRLLGRDLETTIIVENTPDCCRGYERNAVLVEDYEGGELADHTLHILLALLRDLVERHEKEGITVPEYIATTPRLSQQNVLTDKGTAMQAYCLRGVEDECAVPHSTVSKYLSPSCDNLASAVPRPAQQQPRMRPGGSLGTRRQHARLQRIVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S4A1</accession>
    <name>A0A088S4A1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative</fullName>
            <ecNumber evidence="3">3.1.3.56</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_111020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.56" evidence="3"/>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696949.1">
        <property type="nucleotide sequence ID" value="XM_010698647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S4A1"/>
    <dbReference type="GeneID" id="22572967"/>
    <dbReference type="KEGG" id="lpan:LPMP_111020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_110014000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_111020"/>
    <dbReference type="eggNOG" id="KOG1976">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5780965at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004445">
        <property type="term" value="F:inositol-polyphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039737">
        <property type="entry name" value="INPP5A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12997:SF2">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE-5-PHOSPHATASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12997">
        <property type="entry name" value="TYPE I INOSITOL-1,4,5-TRISPHOSPHATE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="467" mass="50888" checksum="FFDBB141FA07AD70" modified="2014-11-26" version="1">MDEREGGDMVSSSSHPRHRPTNAVQARRRLSFEGTNASSNNGDTNGQVSGRGVAANRPSNASYTGTDLISELDVNADAFFTAIGSIVFLSPRIMGIASCLSIPHRTYIPVVDDPLTYAGEAGRLFHSGKFAEAGRSRKGFLLLSLRFGTVQLNVCNVHLFHDDDNRVALASSPSPYTGRRARAMKEAIAECSAVVDLSEPLFIFGDYNVRLDGKLLAEWVEEKMQVTVRPEKKRLRCPEHFWELFTDPDTQKELRTRFDAELQHLMNEVALLSSVELAEMPIHFAPTYFRVAHRTPTEAAVTSAAATSAAAVATTQNVAATPDTQQSTSALSDLVGRADDISVEEQEQTEGVRVRPPLSVLPLPKATLANVPLTHVTASPYRDNFCHDRLPAWCDRVLFNVAGLEWIAGDRARSAHPQTQAASSVLGSAASGSDGLKGKQCSDQSCWHAYASIDLIHTDHDGVFILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S4C6</accession>
    <name>A0A088S4C6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_111320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696979.1">
        <property type="nucleotide sequence ID" value="XM_010698677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S4C6"/>
    <dbReference type="GeneID" id="22572997"/>
    <dbReference type="KEGG" id="lpan:LPMP_111320"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_110017700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_111320"/>
    <dbReference type="OrthoDB" id="270162at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="258" mass="29296" checksum="D6F908F560099356" modified="2014-11-26" version="1">MTDVACMVYSGLGGVIMVCLLGVVTLGFFISTYYYRRVCLRTEKRPPRVVCFDLLKMVTAGFVASLANYTFTAKVTWAAGGITVRNKPLEGIGWYGAISVVDVLIGTPLSIAIGRLINRTCQLLEKQMRTPSPLKVTIHQNTIYGKYSDEHDSTCDYRDFVPPVRWVWWYSQTVTWTWACVLGETISGLIVLYSFLLVKSVWNPVAWIAVMISFWNVNCLLKQYVVVLFGRTILSYLRLALIDFFNKYTQRTPAWPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S4D8</accession>
    <name>A0A088S4D8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_353530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703290.1">
        <property type="nucleotide sequence ID" value="XM_010704988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S4D8"/>
    <dbReference type="GeneID" id="22579382"/>
    <dbReference type="KEGG" id="lpan:LPMP_353530"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350043200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_353530"/>
    <dbReference type="eggNOG" id="KOG4179">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="47375at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06532">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002654">
        <property type="entry name" value="Glyco_trans_25"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01755">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl transferase family 25" evidence="2">
        <location>
            <begin position="20"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO02490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="285" mass="31271" checksum="6588D0AF70B877B0" modified="2014-11-26" version="1">MRTPHLWRPQTTSRPFSLERIFVINLDRRPDRWVAIQAVCARAGLPVERTERVPAIEGSLVDVNVAYRCGLVSALGLRRLKEPSEHHIWGMDLNKAALGCALSHIHLWARIAALGKVSNVSAEASAVVLPKQCFLVLEDDSTLADAKGSDSESPAASPSPPFLGQLQRRMSSVPPDWELVYVSGLDTARQCPHMQVAEGVAHVPQYHRTTNAYLVTPQGARRLLATCVPLTFQLDTVMTMNVGYPPGMVGVAGVKTLPYVLDPVCYTLQPPLMRQSTQLGTDIQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S539</accession>
    <name>A0A088S539_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Small G-protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_356410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703570.1">
        <property type="nucleotide sequence ID" value="XM_010705268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S539"/>
    <dbReference type="GeneID" id="22579669"/>
    <dbReference type="KEGG" id="lpan:LPMP_356410"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350072600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_356410"/>
    <dbReference type="eggNOG" id="KOG4252">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6585768at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04106">
        <property type="entry name" value="Rab23_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002136">
        <property type="entry name" value="Small rab-related GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034114">
        <property type="entry name" value="Rab23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="175"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO02770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="299" mass="32448" checksum="72D33FEB0B9BA528" modified="2014-11-26" version="1">MLDEEESIKVIVVGDGNVGKTSLLHRFVKGYFIDQYRKTIGAEFMEMDVFLRSTNSTVRLMLWDTAGQEVFNALTQAYYRGAGAAILAFSSVDRDSFMSVSAWKQRVESVCGPITMVLCQTKFDLSHEAVITNAEAEKLANQLEVPLFRVSTKDDFNVTQLFEFAAQRCVASATQDETTEEQADDVGNVGRLNETEESTAKVSAAAASSMAPGKQHGDGGAVTAHAPSTAAAFPSPPAARKSKACGPDAIEEATRTACNSSGGWKEEEKPSSRAKSTVILMDRKGKTHHKKKSLKCLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S5L9</accession>
    <name>A0A088S5L9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Myo-inositol-1 phosphatase, putative</fullName>
            <ecNumber evidence="4">3.1.3.25</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_150890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="4"/>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697464.1">
        <property type="nucleotide sequence ID" value="XM_010699162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S5L9"/>
    <dbReference type="GeneID" id="22573509"/>
    <dbReference type="KEGG" id="lpan:LPMP_150890"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150014000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_150890"/>
    <dbReference type="eggNOG" id="KOG2951">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10254945at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000033">
        <property type="entry name" value="Inositol-1-monophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854">
        <property type="entry name" value="INOSITOL MONOPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854:SF4">
        <property type="entry name" value="INOSITOL-1-MONOPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="219"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN96811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="463" mass="48745" checksum="AB1A8EC2F3ADC05A" modified="2014-11-26" version="1">MSISVMSTPGPAPASADAGGVNLIEALGVAIEAADKGSRIIWQSFEKRRTAAAAAAIFNTTSSLATGGAASLEAETKTSASNLVTQYSQQCSETITRILRRYSEEVQREKPHLHFAFLTELNPDTPLSDDYTWVIDPIDGAISFLHGLPDCCISIGLTYRKQPVLAVVFTPFISSGVRLTVAAAAVLNAVQQQQQQHQQHQQLASSPASSVTTAAAPGAQSSFVGASPRTPLGTSKIKKTDEPEASAAPAIALPPALSAPLLTSLSRASALPHTVPIITHTTASVVPECNGELFTAIKGLGAFVNGRQIRVNAKAVPTTSVVVFNHPCGVMLSTPEAVNPDSAIVRRRKYDAVIDCSVAMREELLRLPVTALRCSGSCATTLAHVAAGRVDAYLEPAGKIWNVCAGSLLVAEAGGVVYNMLGRPLDMAYDATIVAAATLEMADLMTEKCVRHGFGQYWLPETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S5Q3</accession>
    <name>A0A088S5Q3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_151390</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Gln) + L-glutamine + ATP = L-glutaminyl-tRNA(Gln) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20121"/>
            <dbReference type="Rhea" id="RHEA-COMP:9662"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.18" evidence="2"/>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697514.1">
        <property type="nucleotide sequence ID" value="XM_010699212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S5Q3"/>
    <dbReference type="GeneID" id="22573559"/>
    <dbReference type="KEGG" id="lpan:LPMP_151390"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150019500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_151390"/>
    <dbReference type="eggNOG" id="KOG1148">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250478at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004819">
        <property type="term" value="F:glutamine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006425">
        <property type="term" value="P:glutaminyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1160.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.800.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000037">
        <property type="entry name" value="Glutamine--tRNA ligase cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004514">
        <property type="entry name" value="Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00440">
        <property type="entry name" value="glnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF4">
        <property type="entry name" value="GLUTAMINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="10">
        <location>
            <begin position="98"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="11">
        <location>
            <begin position="401"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="12">
        <location>
            <begin position="512"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIN96861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="616" mass="71058" checksum="B1A43FC6BDAA66F5" modified="2014-11-26" version="1">MHGAESSAAPRLWLLKHTHPSTRSYRTYYPFKTLTKTTFRRFLPRLAKMAAPAAAEVEVETKRDLSVLQSGRPVPGCRNTPELLAAHDAVTGGKPYFRFPPEPNGFLHIGHAKSMNLNFGSARAHGGKCYLRYDDTNPEAEEQIYIDAIMEMVKWMGWKPDWVTFSSDYFDQLYAFAVQLIKKGKAYVDHSTPDELKQQREQREDSPWRNRSVEENLLLFNRMRQGRYAEGEATLRVKADMKSDNPNMRDFIAYRVKYVEHPHIHDKWCIYPSYDFTHCLIDSLEDIDYSLCTLEFETRRESYFWLLSELNLWRPHVWEFSRLNVTGSLLSKRKINVLVRGGIVRGFDDPRLLTLAGMRRRGYTPAAINRFCELVGITRSMNVIQLSMLENTLREDLDEHCERRLMVIDPIKVVVDNWKGERTFECPNHPRKPELGNRTMSFTDTFYVDRSDFHTEDNNKKFYGLAPGPRVVGLKYSGNVVCNGFEVDAEGRPTVIHVDIDFERKDKPKTNISWVSATACTPVEVRLYTALLRDDCAAIDPDFLKFIDEKSEVVSHGYAEEGIKGLKHFESIQVERFGYFVVDPDTTADHLVMNRVLGLREDKDKATVAEPAPAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S653</accession>
    <name>A0A088S653_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Clu domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_161620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN97036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697689.1">
        <property type="nucleotide sequence ID" value="XM_010699387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S653"/>
    <dbReference type="GeneID" id="22573741"/>
    <dbReference type="KEGG" id="lpan:LPMP_161620"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160022100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_161620"/>
    <dbReference type="eggNOG" id="ENOG502RREF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271174at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025697">
        <property type="entry name" value="CLU_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13236">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51823">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clu" evidence="1">
        <location>
            <begin position="1"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="691" mass="76349" checksum="8E3F0EDDB0BF3067" modified="2014-11-26" version="1">MDRVYIKCCSAFSSAAANWNEAYQVALEMGDSTMQLATARLEELLRVERAFEEEAAQGAMRIVTMDPNAPRSVPKELLCYRDMNIFYRVLPDGRSGRNIVATLRGVLQSRSASLTVPLTSLLMYRGIPVLAQALAPFGTEPIKIYGDGAESDPEVAAEVEIIADALRTPLPDQVLCEVYRSLDGRMYVTNTNITTIALDDSMLIGSPLKRPEMLALCPCVTATCEDTLSVLHNAVVMEALWCVLDAAVDQQCRRLSDTLHFYGVNLCLLGGVLDAFAERYGDAADDVQRFTEVVAIEMIARTIKQEFYAEVQAKRLGVDEVGVNTCYARHLRAALHSEHRERFSQLVLRKYAIDNGSGHADGLLRVLLDVRRDRCSAIVERVSWLIGACSAPSADGAESRRTVAWAFLVAGRITPCLCDPKLMCSLEPLYRSWRTGEAHCFACCYPLQVKVAMWQGRVGDGLNLASTAVEQVTARYGNTSIRAVQAQRTFMKLLFTIPSLENVREAYSMATCILEVYKDHAGPITRAKCHIEVGYCLLGASAVMNVVGEAARHFQAAEQLLLLASLRSSNGAWLYLQPSLGLVRCRQLGQQDGPVPLKALVADALYLSRAAAPADYCTKYLWVLGMELAAERNYAESAQILTTAYRMAKRTQRTRLDVDRLHGDTLRVYSDWDPEQYAAYCTAIAEGARVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S7I8</accession>
    <name>A0A088S7I8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_200590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698258.1">
        <property type="nucleotide sequence ID" value="XM_010699956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S7I8"/>
    <dbReference type="GeneID" id="22574266"/>
    <dbReference type="KEGG" id="lpan:LPMP_200590"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200010200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_200590"/>
    <dbReference type="eggNOG" id="ENOG502SEQ0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="258258at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="73"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="122" mass="14198" checksum="6E2599FAC267658B" modified="2014-11-26" version="1">MQRLSCRSFVRRAVAASLVSAAACQAPARFSTDYVNKAAKKKVEEGDDERWLEAEIDKNISTPEERYAHAREVELLKRMVSQLKEEHKENIEEAVRERNKELDHLKKEMNDLQQKISKLTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S7Z0</accession>
    <name>A0A088S7Z0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Dual specificity protein phosphatase, putative</fullName>
            <ecNumber evidence="11">3.1.3.48</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_201870</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 13">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="11"/>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698388.1">
        <property type="nucleotide sequence ID" value="XM_010700086.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22574396"/>
    <dbReference type="KEGG" id="lpan:LPMP_201870"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200024100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201870"/>
    <dbReference type="eggNOG" id="KOG0603">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1716">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="165342at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033550">
        <property type="term" value="F:MAP kinase tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017017">
        <property type="term" value="F:MAP kinase tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008330">
        <property type="term" value="F:protein tyrosine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000004">
        <property type="entry name" value="Protein phosphatase Slingshot homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF524">
        <property type="entry name" value="SPECIFICITY PROTEIN PHOSPHATASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="46"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="405"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="9">
        <location>
            <begin position="1225"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="10">
        <location>
            <begin position="1287"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN97681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1382" mass="152453" checksum="F68FD373BD6C0431" modified="2014-11-26" version="1">MYEVFAALRSSSVGPLFLSHPEVSLSNRSCVICIPDFHQDEMIDGYRFRAAYNAGTVGRSYFATRDVAMLLRSSTRTRGASGSFLDDAAKDPIFRILKVISFVLRRPLTEEITAEQRVLVNILHQNVLRISDVLNDEAKENMIVITHYHPKGNIGSYAGRLSHDPEKLLRILIEVVMGLRVLHSHGVYHHNLKLDNVLEDAEGHFCIADAGLWRLFAVQCPEDLVFNGELACLPPEVFDPEGSYAAGEIDVVSDKGAAGVAAVDMWGFGVLIYRLAYGCDPIEIAECSYAQVRERLLGFELCFPPHPHWRFASDIEDVIRWCMRKEPSERPSVLQLLQHTFFKQCLMAGTSSSMRNMSMTSSLAFGGQMMTSSFGDRTMSTPALKGASMSNLAVPTYRSQQRNGFQVDAFLGEGRFSETMLVHLRRNSSNQFAFKIIYQSLLKRLRAPGREKWAREVRRQLVFSRKVDHPNVMRFIDIVEDTKVNCFVVQDYMPSGAIQVVPPVKSDDSFPALQEFLVDVLSGLVHLHDNGVAHLSLTPTNIFFNEDTSHYRIADFGPLFVTADALAESIAAGTPLYTLPSWVQKQRPLHAPSVDVFCVGLLAAAVLPELFTTVWAELRNCEKHSTFAVDAVLSVVRKSTAPLTPALISFIEDALEGKLADARAALKHRYFQNLRFVEHLPKTIVEVTEAELQGAVHSKPETRDEARMLDILAQDPFQESQMLSSVGDATLHGCESCTDTSTSAAATGEKSAVLFFKGENLRCGQCSAELAVALYQCLDCEGYIRCGKCALGNYHKEGHELVPFLIHTVEHSKEGINKAVLVQPSTVPDLHALEMLEMTANFPVGSLTEHLAAQRAAERSIVTRCAGGGSITKGMFGDLEGVIRLPDDVNEQSISVNINGCSFISFRGVGGISGGGLNLGCGANNNNAGLNTAGISFTRADFMSPKDIGSLCLPPPPRLSLMKAKEVKRVALPKAKEMEDDDWQQELERCRTSNHTELLLYNYGLDAVPSEVYNPPLLQVVVLDVSQNNLTSLPQELSFLAHLRKLVVSYNKLTELPDSLGNLNELESLDASHNALIDLPQTFIYLSFLASVALDYNNFASIPESLLDILAVPLCASASNVENCAIPTSQLGGARLASSMGNLVGPFMGSASGSVSKTVIVSPKLKVIYLASNDRLTTLPPPHRLQCFDDLTIALDNEPSLYKHYYEKKLDTILPNITVNWNKLYPDEIIPCLYCGSLRSAQSQMVYRKLNIRYLLTVGRQLVPVPPEGGHHKVIVVDDIPGADIRMSFQEAVNFIEESQSHKEGCLVHCFAGLSRSATTVIAYLMMKKGMRLDEAYLVTKKGRPAILPNKGFFDQLVELDNELYPEPKRPLDIASLGRSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S8H6</accession>
    <name>A0A088S8H6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_204170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698618.1">
        <property type="nucleotide sequence ID" value="XM_010700316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S8H6"/>
    <dbReference type="GeneID" id="22574628"/>
    <dbReference type="KEGG" id="lpan:LPMP_204170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200047800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_204170"/>
    <dbReference type="eggNOG" id="ENOG502RZQ4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251741at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47822">
        <property type="entry name" value="CARBOHYDRATE BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47822:SF2">
        <property type="entry name" value="F-BOX AND WD-40 DOMAIN PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="325" mass="35070" checksum="F98B3F87BB2C0765" modified="2014-11-26" version="1">MSLDIEAHQLLEITQHIYFCSLSPDAELVACALGNGVVCTLNAITFDVTARGAPGKDFVDVPATCVRWAPAECDCDWQLVSSSTAGGVMLWYWDCSEFSLRRGTAAFEENNEVMMLDVSPSGKRVLTAGSDRIVRLYDSKLTLLSQLTEGMNSDSTSHPTHINRIFSARFITEVVAVSAGWESPIQIWDLRACRSNRQVVGVQGVSDCLEPVPGTHMVLVASPKSLDTIHIVDSATGRVLDQNSQAVCSQLNPTERVTVCRYQAETGHVWCLTTSPPSVIAIAFPSGAIVARAALAHTPLNMTMNASRVIVGCKNGVVLQVSLSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S9E5</accession>
    <name>A0A088S9E5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_211730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698958.1">
        <property type="nucleotide sequence ID" value="XM_010700656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S9E5"/>
    <dbReference type="GeneID" id="22574995"/>
    <dbReference type="KEGG" id="lpan:LPMP_211730"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210021300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_211730"/>
    <dbReference type="eggNOG" id="ENOG502SJR9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267536at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="299" mass="32013" checksum="EB1EA646F1971B82" modified="2014-11-26" version="1">MEKTRCCRHCGCAIRYCPCCGAELAGKRDNAVKGLSSGTGGRLLSCNYSFSPHTAADRAEGSGTPAPCCHSTSAWRERLPHRAVSAYEVYLAIVHGFVVKKGDEEADAARAVALTPAAASVAEGGQHNDEQMRGAALSWLRMMPAEKRVYEVEAQLWQARLATVSREPTTSAVAAATALRSSTAAPALAHNLEEGSSSAAAELYTLPLAERLLPQQPASRLVAKVSSKTLTSERLPRSKTSFALFRANVKGRRKMSMKEIAAVWRHMSAEEKAPYDSAAANQRTEQLLSQIPSAPGSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SAQ1</accession>
    <name>A0A088SAQ1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA repair and recombination protein RAD54, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_240730</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699413.1">
        <property type="nucleotide sequence ID" value="XM_010701111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SAQ1"/>
    <dbReference type="GeneID" id="22575482"/>
    <dbReference type="KEGG" id="lpan:LPMP_240730"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240013300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_240730"/>
    <dbReference type="eggNOG" id="KOG0390">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18004">
        <property type="entry name" value="DEXHc_RAD54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000021">
        <property type="entry name" value="DNA repair and recombination protein RAD54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000332">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="453"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="796"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="749"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN98706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1126" mass="123502" checksum="DE1E327811973580" modified="2014-11-26" version="1">MRKSTAGSAVANGTFRPPTTSGEDKPAARKPSVHPLLPATSASAVPRFMTGWRTLSSGSCKAPGSGDSRNTNDSAADLPGPTVALVTSTGVRREVMYPTVTPHSAGSTANNDLLAHRLARRSQIDYHQPESASKAVVARTLQAAAAAQGKTGDEAEDCEDQGSGAAKLIRVEAGAGGVKSVPSAPEAADGNAASAAKGSHEAAAAAANDDAIPTDKVVSCYPASPYGKLYFQVETDGATRHESVGIVIIDTELLGVMMYDRVGRQYGNRPDPGYPIKQEEVDNAKAGSTLKVGTKHVLLITALTEEAFRSGEFFLRSEHDLRVREDKAKAKADAAAAEEAKARKPEMSFGISLGNNSAFASILFRRRPKDGETGFVVPVAGRPKMGKNGIIMNELRPLHDPDREKAVVLFRADYKRDLHGRRQVSVVVDPIIGDKLRPHQIIGVKFLFDCITGERMLGYHGAILADEMGLGKTIQTVATIYTCLKQGKHGQPTARKCLVVTPSSLVKNWCNEFDKWLGEGTVKHFAISESTPKGDRIISRFDGDGDVLVISYDQLRKYIDRLSGLRFVELVVCDEGHRLKNAEVKTTKAVDMLPTRNRIILSGTPIQNDLSEFHAMVNFVNPGILGNQDLFTRVFEEPVSLGRDPDCPDHLKSLGRDRAHYLSMLTQRFILRRTQSINESYLPPKVDVTVFVRLGAKQEQAYQKLADIVESAECTPLVLISALRKLCNHMDLFHDAVHLSHQVGNGIGASAQQQQTGRRRGRSSAADEPQGIPFSVLPKGFKPGSLSMDYGSKMHFVSLVLNELRENGEHDKLVIVSNFTQTLDIIAALCNSKRIAYFQLDGSTPIKKRQQLVDYFNVPDSQEVVFLLSSKAGGVGLNLIGANRLILFDPDWNPANDAQAMGRVWRDGQKKRVFIYRLLSTGTIEEKIYQRQVSKQGLSANVVDMQEDSKQHFTLEELKSLFKYKVDTLCDTHDLLGCTSCEAAEPLATSDRRSRGKQAEELKMQFRKVGQPKKKCGPRMDELKAWRHISSVASFNLDSVTRAVARHAPSLLSFLFADERDNTKMPGPVVSTRVKVDRPAFEDDEDTITCASQAAIQQQESEMEIEVIDDDDEEEAEFDFSEKESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SAQ9</accession>
    <name>A0A088SAQ9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Triosephosphate isomerase</fullName>
            <ecNumber evidence="11">5.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_240830</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Glycosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="11"/>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699423.1">
        <property type="nucleotide sequence ID" value="XM_010701121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SAQ9"/>
    <dbReference type="GeneID" id="22575492"/>
    <dbReference type="KEGG" id="lpan:LPMP_240830"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240014300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_240830"/>
    <dbReference type="eggNOG" id="KOG1643">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6715177at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020015">
        <property type="term" value="C:glycosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046166">
        <property type="term" value="P:glyceraldehyde-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000020">
        <property type="entry name" value="Triosephosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139:SF2">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="Triosephosphate isomerase (TIM)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="7 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10" id="KW-0327">Glycosome</keyword>
    <keyword evidence="8 11 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00084116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN98716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="251" mass="27160" checksum="DDB279DDEDF90AE5" modified="2014-11-26" version="1">MSDKPQPIAAANWKCNGTTASIEKLVQVLNEHHISHDVQCVVAPSFVHIPLVQAKLCNPKYVISAENAIAKSGAFTGEVSMPILKDLGVNWVILGHSERRTYYGETDEVVAQKVSDAYLQGFMVIACIGETLQQREANLTAKVVLGQMAAIAAKLPKKAWGQIVLAYEPVWAIGTGKVATPEQAQEVHALLRKWVSEKIGADVAAKLRILYGGSVSASNAKTLYMKHDINGFLVGGASLKPEFREIIDATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SAY2</accession>
    <name>A0A088SAY2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Inhibitor of cysteine peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ICP</name>
        <name evidence="4" type="ORF">LPMP_241740</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699513.1">
        <property type="nucleotide sequence ID" value="XM_010701211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SAY2"/>
    <dbReference type="GeneID" id="22575583"/>
    <dbReference type="KEGG" id="lpan:LPMP_241740"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240024700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_241740"/>
    <dbReference type="eggNOG" id="ENOG502SEPD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271849at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036331">
        <property type="entry name" value="Chagasin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052781">
        <property type="entry name" value="Cys_protease_inhibitor_I42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018990">
        <property type="entry name" value="Prot_inh_I42_chagasin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36530:SF1">
        <property type="entry name" value="AMOEBIASIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36530">
        <property type="entry name" value="INHIBITOR OF CYSTEINE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09394">
        <property type="entry name" value="Inhibitor_I42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141066">
        <property type="entry name" value="ICP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0789">Thiol protease inhibitor</keyword>
    <feature type="domain" description="Proteinase inhibitor I42 chagasin" evidence="3">
        <location>
            <begin position="15"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN98806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="113" mass="12497" checksum="A66D5050E396C9F7" modified="2014-11-26" version="1">MHSPLTVKDHNKTVTVKLGETVKIVLNGNPTTGYTWTRAGFLGMESLSDEHLEVTSKYTQSPTPSGMVGVGGSFMVTVTTKMKGHNTLELLYIRPFEGLKLDSQKFILHFIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SC84</accession>
    <name>A0A088SC84_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flagellar attachment zone protein 1 conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_261940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700013.1">
        <property type="nucleotide sequence ID" value="XM_010701711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SC84"/>
    <dbReference type="GeneID" id="22576097"/>
    <dbReference type="KEGG" id="lpan:LPMP_261940"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260024100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_261940"/>
    <dbReference type="eggNOG" id="ENOG502SDQV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272700at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056614">
        <property type="entry name" value="FAZ1_cons"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23398">
        <property type="entry name" value="FAZ1_cons"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flagellar attachment zone protein 1 conserved" evidence="2">
        <location>
            <begin position="128"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="218" mass="24831" checksum="1A699F0C0008AD88" modified="2014-11-26" version="1">MSRRESCIWHPMPEEVRRSSVQSRRASLAAGRRKSLNGNAPDWEVEAPPTPLRGDYSARENAAMVRTPREAAAPEAESSKPLQGPGVVARRDVGLTAVVEESQWIEDEEEEAALQSSADPKAARKSRTRHMVRFHGGKWPRVLRKRRSEIMASFLEDIKDGASVMGDEAKRLKIKMHDCMEVTFVIYSESRSRQKEIHMALQQYDFPKTCQQYTSFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SDF3</accession>
    <name>A0A088SDF3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_281380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700478.1">
        <property type="nucleotide sequence ID" value="XM_010702176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SDF3"/>
    <dbReference type="GeneID" id="22576583"/>
    <dbReference type="KEGG" id="lpan:LPMP_281380"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280019800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_281380"/>
    <dbReference type="eggNOG" id="ENOG502QWP3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271923at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="428" mass="46755" checksum="3C44FCD0136C8705" modified="2014-11-26" version="1">MTSRQPTRRLVDVLKQNSKKTLDRHAAQLAAAASSLPAEAIQTRFLRNQFLINPKALQLLSTEEQLTRWHVFGVYKPPFCPMRRAEAADNYHNVSVESFVEAALQSKNIYPLLKRVLKPAEVRVRVLYNLDSFASGPVLISVSDAHHYATSLQTTTMEYDLLVGGHLPVHGTGNRTTIDVAQLFPSAGVSINTGTVPAVVPEAHYVVKENGYYSVHPVSLLRIVIRSPPVSQPPALERFAREQLGTCVMGDPLVMGELMHLRANPAGSSSHTSATSTPKSSDSAERGRGAAEDVGSGSKRDLAAHAAAMKLAANPHIVSWRGDCDFPRVFIHLREVRIDTSAETPSSTTEAAYVQDTHSMPTGTTMGFMGGHHSGSASPAQHLSEAREIHLHCRRCFDGLLQKQLSASFKSRRIGLLDGSWTPQTEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SDR5</accession>
    <name>A0A088SDR5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_282690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700608.1">
        <property type="nucleotide sequence ID" value="XM_010702306.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22576714"/>
    <dbReference type="KEGG" id="lpan:LPMP_282690"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280033400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_282690"/>
    <dbReference type="eggNOG" id="ENOG502RXQ3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="245103at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="609"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1567" mass="166035" checksum="59C5EEC914067433" modified="2014-11-26" version="1">MTTAGLSRAYAVLRQLDVLRAESITNPLPISGDRHPRARSAEPGTSELASPPFRSRGESAGRSVRLQEFRPPLPAERRGLHASHGDIIWEDLTNMDVTELSSFPPAEATHYRGYSKHPYTYAPVGSHLRPDSPSHDGPQRELSQLTAAEGGCHAAAATTSAGTQPHHSSLSGEYTADDGHDQHVPPPPPLSRTNDASLLLLSSSNSPLPHHRYRREVSTERPLRRSPPVRAAVPSPAVLPSLFTSEAARAAAVQASSSLELCFDKDDMHAVLASAAAAAASPVLTGRTQQGWGAVQPSSAQLDGAAVAETDALCRIHRRITHDAHRGTEAASTYTQSLGTSVDASVTAEAVATPSSLNYSPLMAMPDDDAQSASSSSDVTAADGGRHPLWQLPMSRNGVGDKQPRRHRIAAASAASPSAPVKDVFITHGVGRPLGALPQGSRSVGQRHQREATAPAAVAPLCGVSSPPPSGDLSSLSTAAGPSVRADGGRGANAAEARQPQEEEERTSLSRDCYLPPHVMPSPRDAVDTGPFPPRAPADRSDKGVGDDGSGCNGDREGSDGLRFNDLFPGSGGEGSIGQEGHPREDESLPLRDFSGAVEERSVQRAAAHIDHQRCDSYRPSQGNSRGQNFTRDARHRVIPLFPAAYRNAVPFLDYLERVNAASSHQLLKELAAMREAWVTSTQVEDAAGGGGEYSRRATESVVVDCLAMDLLLNKASALECIVVPWLRTRLESMMAVHSAERVNSGAGNYRNQGKAVAANALRRTEADAEGVGEGVAAVNNSVLCAIIGLGGVAFTLLPTLLQLLLWLPPPSPASVCDARLVGLAIRTVGGAEGLETVIRIVQQQTEGAHVLTAAAYALSTYSFELVGHTSAVCIPAGAMRQFGAGGGADSLFQLVPDDFSSSTASSFSASPMMEELRPLWSRDPLLLSPTATTGAPTGLHLLYLQSPPPYRPTHVMVDAEVARCELLAYLRTDQFCITHAYPYIMVLLNDALNARLLSAVLTPTALSLYSPILFQLRRGLHRVLADDITNTAPHQRGNVGSCDIDDKAATAQGLLRLPLLPYSLHRFFAGEKDMLFALESALVHALLARSATALVQEQALMSLSSLPPEARVHVVQPVTDFFISSARKLHLRQTTTMRRFAAQASRGDPPATGPGPCNGAGGVDASENVTVAAAIAAGTVCVNSLASSSCVDGCIAALVPVFQELLHSPLWRVRHAACVGLSRIGPLTADPSSIVHFLLTRLALQDPLAEDERSLSQSPSAVATWSPQLPLQCATVVWCLAQQRQGGVRALLQLLQDPKQPPQVHHWCAFQLAEVDVHEACAKLNGGDSPEADALLDELVQVLGKLIVTQGALEEDTMLLCVRALAEVVHRHHTTATSPVSSAAAPAAVVAAFLLDTIQSAHEAAGCCQGEEPNTCFTVLTSVLEAALLPTNVLKALCLYLCRYGGGHGELYVCELLLQSSSVAVRTAAAFGLRGCGAKALRSVVFGMNDGSFDVRREAFETLTAIGAPAALEVLQQRPAEHRHQVQAALRDCLLQDASRPVSRKVAEAVYRALLSEELLGARELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SH27</accession>
    <name>A0A088SH27_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_322280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701912.1">
        <property type="nucleotide sequence ID" value="XM_010703610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SH27"/>
    <dbReference type="GeneID" id="22577969"/>
    <dbReference type="KEGG" id="lpan:LPMP_322280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_322280"/>
    <dbReference type="eggNOG" id="ENOG502SEMY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272958at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1058" mass="114659" checksum="24EC4EA03EFCF71E" modified="2014-11-26" version="1">MEVNIRAFSDALDGILAAKTSSSQTSHSAALHKKPFPFSQSCVDHSQNKCSKPAAPEAFQASLSNNDPEVLSDAAAVIEPSMQTEKPIAPQKKPTQQLQASPSNDSEKTFFLKEAERKSRSPKIAKFHKRENLPLRSATVKSSNTTVEGFLEHLKSAELVAFKVVEATGVGIGSALLTPQNVRLWMSRSQLPSKSWVTCTSFSHEACAVFELENRVDMRKRRELLSYTHNKVVDLPTGGSTDTYVVQDLVAVLVVEDDIERPSLHLDSAAFPNQERHVFSVVIETSSSRHGGFLVLTTTSAAPSCVTSLKVPGTQLNTFLKITISPLASEARPKLIKVRAVCFFRSDTRTTERVIPLQKDDSSLKEGVEAVLKEGAKTTRRSAHSISERRGERCAAETEPTQSPLLSRKGHRQAKKSEGVAHLASLDHDSGADVADFVKAIALASSRQDNAAPEHSSSCSGCSVEYDWFLDRLVDVSASKDNSKDNACRKANLPDAGSETGSEAPVQEYIRTLQAWNAVPALSMKSALTYCLCETTSFSASTIFATKLFGYEAQNHLSQPFKLHFFVVSNFDDIDQSSEQVRSSGVHLPPVHFLSAVASQAASLGYTTELLFTCPANNGFGCALRPHSCTSGSSDAHCKLIFVVPTHCNGEMNEGGIASVTKRLLRTALSIFCESADKRGSRLGQDCAFSRHSTLPCTKPCGALRLLIDGTCCFDDLIPVFAEWAEVSGSLRYYGSASQRTLQLLFFPSLLTRSSGGGEQLGDLSELRREAQWSGLNLRLSGLWRRDINEGGITADNIVALEANYYCPATYVWQSRRGALRLVLTDSHFMEYLLCVDGLVAPSPLVSLATSYYGKEADSTTHTLSLTTLSEAPWMMLLQTFKKVRKSPGVSAAALSEGAAADFLVLRRHVTVSFAFHILSTAFKRGWARVSASIPLCDGHIRDAAVELQNVHGASLEKGVNGGGGVRSSLGILDEDAFMDTLLQWQYPFPNVVVLHCTDVLHPGPTSSPALTGSLCTSSSGVQEGVLSLFSEEVLHSFAFVPKLDEALSLLQGVTCLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SKJ4</accession>
    <name>A0A088SKJ4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Chaperonin HSP60, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">groEL protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_352100</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02347.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703147.1">
        <property type="nucleotide sequence ID" value="XM_010704845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SKJ4"/>
    <dbReference type="GeneID" id="22579239"/>
    <dbReference type="KEGG" id="lpan:LPMP_352100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000039600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_352100"/>
    <dbReference type="eggNOG" id="KOG0356">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1733909at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000001">
        <property type="entry name" value="60 kDa chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000592">
        <property type="entry name" value="PRK00013.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009487">
        <property type="entry name" value="PRK12849.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009488">
        <property type="entry name" value="PRK12850.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009489">
        <property type="entry name" value="PRK12851.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45633">
        <property type="entry name" value="60 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00080006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIO02347.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="564" mass="60148" checksum="0EA79503EF75D467" modified="2026-01-28" version="2">MFRSAVRLAGKDVRFGDKARRSMQKGVTRAVAAVATTLGPKGRNVIIEQAYGAPKITKDGVTVAKAIEFKDPFENMGAQLVRQVCNKTNDLAGDGTTTSAVLVDSIFSEGLKSISQGTNPIDMKRGMDRAVDVILKSVAQQSRPIKGEEDIVQVATISANGDEEIGKMIGQAMEKVGRDGVITAQDGKTMATELEVVEGMKVDRGYVSPYFVTDAKAQKAELENLYVLVSKKKISIIHSLLPALNHVVRSGRPLLIIADDVESEALTTLIFNKLQGKLKVCCVKAPGFGDTKEGVLEDIAVFTGAKVVGDENTGVELDAKSFDPSILGSVKKVTVTKDDTVLLNGGGDATAVKERVDLLRERVEQEPVEYNREKLQERLAKLSGGVAVIKVGGGSEVEVNEKKDRVVDALCSTRAAVQEGIVAGGGTALLRASKKLEALANDSSLTRDQRTGVNIVRNAIRLPAMKIAANAGKEGAVVVEKVLEAAEESTGYDAQNDKYVNMFEAGIIDPTRVVRVAISDATSVASLMMTAEAAVVEAPKESKKNGKRAPAAEVEEDEELFGSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SLI2</accession>
    <name>A0A088SLI2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Casein kinase II subunit beta</fullName>
            <shortName evidence="2">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_355210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703452.1">
        <property type="nucleotide sequence ID" value="XM_010705150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SLI2"/>
    <dbReference type="GeneID" id="22579549"/>
    <dbReference type="KEGG" id="lpan:LPMP_355210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350060600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_355210"/>
    <dbReference type="eggNOG" id="KOG3092">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3971593at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1820.10:FF:000011">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000001">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01101">
        <property type="entry name" value="CK2_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="215"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO02652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="276" mass="30923" checksum="9CB321022BE99E64" modified="2014-11-26" version="1">MDDAYSPENMEYEYEDEELVSWITWFCDLKGNEFFCMVDREFITDDFNLTGLAPIVPFYHYALELILDVESMESDGLTEQQKRLVESSAEILYGLIHARFITTGRGLKLMEEKYVQGEFGSCPRVFCEGHALLPVGQSDVVRESSVKLFCPRCEDIYHPRSNRHRSLDGAFWGTTFPHLLLMQLRERGVSITPPNQQYVPKVYGFRIRKPGTTLITNATGEEETGTASAGAGDVSLKTEAGAHHREEEGAVAGSTAADQRRTVESSTSTSSKGKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4M6</accession>
    <name>A0AC62A4M6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Heat shock protein 83</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">HSP83</name>
        <name evidence="1" type="ORF">LPMP_3320060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="XUY36714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="705" mass="80907" checksum="AF8312B058703C87" modified="2026-01-28" version="1">MTETFAFQAEINQLMSLIINTFYSNKEIFLRELISNASDACDKIRYQSLTDPSVLGEETHLRVRVVPDKANKTLTVEDNGIGMTKADLVNNLGTIARSGTKAFMEALEAGGDMSMIGQFGVGFYSAYLVADRVTVVSKNNSDEAYVWESSAGGTFTITSVQESDMKRGTRITLHLKEDQQEYLEERRVKDLIKKHSEFIGYDIELMVEKTAEKEVTDEDEEEDESKKKSCGDEGEPKVEEVTEGGEDKKKKTKKVKEVTKTYEVQNKHKPLWTRDPKDVTKEEYAAFYKAISNDWEDPAATKHFSVEGQLEFRAIMFVPKRAPFDMFEPNKKRNNIKLYVRRVFIMDNCEDLCPDWLGFVKGVVDSEDLPLNISRENLQQNKILKVIRKNIVKKCLELFEEMAENKEDYKQFYEQFGKNIKLGIHEDTANRKKLMELLRFYSTESGEEMTTLKDYVTRMKPEQKSIYYITGDSKKKLESSPFIEKARRCGLEVLFMTEPIDEYVMQQVKDFEDKKFACLTKEGVHFEESEEEKKQREEKKAACEKLCKTMKEVLGDKVEKVTVSERLSTSPCILVTSEFGWSAHMEQIMRNQALRDSSMAQYMMSKKTMEVNPDHPIIKELRRRVEADENDKAVKDLVFLLFDTSLLTSGFQLDDPTGYAERINRMIKLGLSLDEEEEEEVAEAAPAEAAPAEVTAGTSSMEQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4M9</accession>
    <name>A0AC62A4M9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase M20/M25/M40, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3320420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="XUY36750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="472" mass="51182" checksum="D9528480A5A26E51" modified="2026-01-28" version="1">MGDCDWTVIQKAVGAEWDASIIPALSAYIEVPNQSPDFDPHWATNGLMEKAFHILIDWVKGQNLLGLSYEFMEVEGRTPFLLVEIAGTERTNNTVLMYGHMDKQPPLRPWAEGLDPHKAVMRDGKLYGRGAADDGYAIFSAITSVSVLQRHGIPHGRVVVVIEACEESGSFDLDYYMAQCKERIGNVDLMVCLDSGSLNYDQLWLTTSLRGVTGGVLNVQTLTEAMHSGVAGGVVPDTFRIARELLDRVEDSKTGTVLLPEAHCEIPDHVAKSMVSMKSVPFKQQFAMADGVSAEPGDNVELALRNFWKPSLTVTGANLPEPQIAGNVIRTLTSLKLSLRLPPLVDSGKATQAMAKLLTTNPPYGAKVWFEPEVPGDGCATPELKPWLSNALNEGSKMAYGNPLAYQGMGGAIPFISTLTKMYPQAQFIVTGVLGPKSNAHGPNEFLHVGYAKGLTLAISHVVAAHFLLAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A518</accession>
    <name>A0AC62A518_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amastin-like surface protein-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2420090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="XUY36899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="174" mass="18895" checksum="66730D632B927A0E" modified="2026-01-28" version="1">MGLLPPFVGALLFSAIQFLVLLFVVIATPISQIDSMTSKMCYTLWGSKSDCSKVGYTGRGKMAFGNCGQRVNNMNGGAAFAIISILTTLVALLFGIMMLIRVSCPVILPLFFTSVSVVTILISWACVAGAFTIKMCGMKWSNFALKYGPGFWLMIVAMCLQVLNVLVLLFISFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A525</accession>
    <name>A0AC62A525_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Membrane transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3420270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="XUY36791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="693" mass="74357" checksum="23399E9A63C647AE" modified="2026-01-28" version="1">MPISPVDKGTTTEAEGSAPPLERCANNCRPLKDTPLPWGQLSIICVVLLTESICWSVLIPFVPSFIAYIKGWDVDSSGYASGFPVGLFMLGQVVSGKLWGMLSNMIGRKVTIVLGVSGCAICMFFFGLSGSLLAMCFWRFTHGLLGGCSIVAKTMISDLTDTTNRAKGLALVSLTWGVGTLIGSAVGGALYNPASSSALALLHISSTSFVGSHPAFLPSAVVAGYNFFAVVICVMCLQESYRDARPLRDVLPPFIVKLMAPVLRFVQPRLPCDCNATDVTAMCADDHNETGSSAPQKPPPTAARPTPASPSTPHTPFGFKQAFLNPLLRRVCIISMLIATSDMMFTEIFPLWVASDVRNGGLHLSPFQISILVLMNAAPSVLANVVFAPVIQYAGGPVRLCIAAQLMYGFFTAMVPTASSLGKRTRFWYTIVFGMLRKAMEAWNYALTMVMVSLTAPQGKVAIMFGIQQSLVCLVRCVVPLVFAPVFAWSIAKPHPFPFNHYLVFLLSVIPLVIGAYIATHVYVPSCNSGDGEEEEEELEGSSDRVGVGNGGQNSRLNSACGSLCSIYSLFGSVSCDVPARESLLRNSAANSLVTLSSPAMTQHTIFEFPTGSHLLMAVEDAVSAPRMQLDEAGDSRDNSSQEGDEVDNNTEYASLADEMAVIPVVPRDGVLEQEDIRIAQRSTLLENEELPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6E8</accession>
    <name>A0AC62A6E8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATG8/AUT7/APG8/PAZ2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0920100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="XUY37327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="124" mass="12846" checksum="4224028B6550883B" modified="2026-01-28" version="1">MSAYVSSTPLEARVARCASLRATNAVPVVVEEAQARGGKAHFSALPRETTAAQLVAAVRAFRGVAANKPVTLTVAGCSVSPSATLGELHDACKQADDGMLYVAYTAERSMGAATWKPCGSCSWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6L3</accession>
    <name>A0AC62A6L3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amastin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0820010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="XUY37281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="187" mass="21277" checksum="8C641BC424C9330E" modified="2026-01-28" version="1">MEFTLALLLYAVLQFIAFLFVLVATPIDMFRLKEDGRFDNSLCITLWGLKNKCYGLKYEDDVFSLWSVCGTRTQRFRTSQAFAIISIFVYGLAAVLGFILLWCCTYLRFVCLALNVTGIVTLCVVWASMAVTYYTLDGQCFGMRFRMKFGSGFVLLVMAWCLDIINIVLLLLSWPVGHASENVETKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RGX6</accession>
    <name>A0A088RGX6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ABCA1</name>
        <name evidence="12" type="ORF">LPMP_020220</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009371">
        <property type="protein sequence ID" value="AIN95202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698167.1">
        <property type="nucleotide sequence ID" value="XM_010699865.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22571832"/>
    <dbReference type="KEGG" id="lpan:LPMP_020220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_020007600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_020220"/>
    <dbReference type="eggNOG" id="KOG0059">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10255969at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000335">
        <property type="entry name" value="ATP binding cassette subfamily A member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001592">
        <property type="entry name" value="ATP-binding cassette protein subfamily A, member 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056264">
        <property type="entry name" value="R2_ABCA1-4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF262">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23321">
        <property type="entry name" value="R1_ABCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="476"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="872"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="933"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="957"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="984"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1053"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1748"/>
            <end position="1764"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1784"/>
            <end position="1807"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1953"/>
            <end position="1976"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="SAM" id="Phobius"/>
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            <dbReference type="PROSITE" id="PS50893"/>
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            <dbReference type="EMBL" id="AIN95202.1"/>
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    <sequence length="2625" mass="284259" checksum="D0C26EEA8BA401FB" modified="2014-11-26" version="1">MLYTSPLPPPFFPLSLLPPPSPYSPVMRPSRDAGQSGGEASTRSSMEGAPEPPRQRPSIASPAVPQRTPQATSVSPPAVRCTEPGAGYYGAWLARGVIAMAPRANRPPATAGTTATASVSSARQPPSGYPSTFGHHAQNPGRQRPAPPLSQQQALSHRCEASPQSKCELQYRRIEIGPLDTARRPCSPVSTASPAFAGASSVSRDRCPFPQSTRGTDRVLSEEGPRGFPFVTQPMPVDPHQQQTGRGESEGVAAGVATATTTHGALPRSLAGDQSFSLPSSAVAVLLSDEELPSAACTEKRPQQQRPQIPLTVGVCSLGAGSPSSPHRMLGTPLPPRNGHSARLENRGYGPGSYTTRGNSRASGSLTVGAAYADVEGGGSDSDTTTSRRRRSSGATESGTDDRTSAYYGGTLGCRDAEAASPIPEINRGATVDDGAAGLRSLVAGDARQRYQGSPTWLDQFGAIIWRDTLERRRRWFSVVLEIVIPLVCAACVVVLWAAFGATSSPNSSSPSNIGDSGYGFSSGRYLSVLCYNETWFGKPNYIDGLVSCSNLDTSTPSSVTCDTVGEEELPVKGLCYAQRGSALGAFVSGMRNGLAQVMPLDDIIAYQWLAKKLPLVDSAAMSLLVGAGLASNTQQSAILSSGKLYFAPCRNVPRDILAYLFRDSKLLQYVYNDTFDTVEAAHRVIKSGERGPTWALVNVRQLDENGFDVSIELDATALPPLAVLIDKAYPGGASDDRSDVYYTSGYTSLMDVLVKYYLTSPYAAGATRAEVDGIQALEGSQVKQQQAAAADAADGVLARRELHDAVPAAPESVGDGVQSFASVAEPRSSPLTLVSQCASSIQETSATLRAKANLTIYLGGMPWVPFKTSQLLAYANTVVGFVIVLAFLYPVSQLTRRLVLEKERRVREATLIMGLPLEHLWCSWFLHSAALMFTISFLMTLLLCTTLLVKSDAFCVFLVVFLFSLTCVPLSGLLAAFFDASRVAALVTPLIYFAMSLLPFAMRSAGPATYLGFSILSPACFALILQDTLARENGDGLAASIFLGGADNPNTATLFGFLILDFAVYLMMMFYLDAVLPKAVGVSKHPLYFILDPIQRCRRKRWEAAWQAAQRQRQAASAAGSSEQQAVPPPPTPMRRSYESAEEAYGGSCGWRCHGHGATDNDRDKDVHGGGEDACDPDGVYEMEAFAPEQLSVRIVGLHKYFQRGGRRFVAVRNFCWQLPNVGVSVLLGHNGAGKSTVMNMMTGMLYPDGGDCYIGDHSVRFDLARARHEIGLCPQHNILWPELTCREHLEFFARLKGLRGAALEKAVVDTLTEVDLLTRQNDLSSVLSGGMRRKLSVAIAFVGGSSLVFLDEPTAGMDVVARRHTWELLLRMSRSRCVLLITHFMDEADLLGDRVAIMSRGQLKCSGSSLFLKSRLGLGYNIFISVHALVRVRELDAFLQEYVPQAERLSTSGGEVNYRLPAQQVDLFPGLLSALDTVGPLIGICGYAISPTTLEEIFLTIARDAAEEDKGRRARVKMEACRVSGSAVALAANQGWLSGLWDCLCCCWCCGGSGGRGASGRFAPDESDKGDDGMDSDNREWSVLDNVNSPYSRDSVSGVTEELTQCSALDRAVVPMQCQSGCSATTSEENQRYPSPTATGYVGSNNGEDAGTSGNCTPAGSASRFSRPAKPLVSKASSPVSQGDVHCSGEAAQATPTYARAVNAEDGRYSVLRVPAAAVTSPVAATESGTAPSTMTAVKRDASADVIWSCEIAFSIATISLLQAEAMMRKRFHIMRRDRRMLCFQVICPVVCVLLAMLLSLTRAYTVDELTMNTSNYPYDTLWDTTGCANYFDSSSNATATSIAPNQRIRDVKAVNLSDFYYFLQDDWYVHGQIGKYSGIACGDPVTAMLPSISRNPVVLLTNYSTYHEFPISMVNFYNLLFKGVRGPSVFITAHVATLPSKSAPVSEDSIRLLLTGIIIMVPFTFLPSNYVAWVVKERECRSRHLQDICGLRYLIYWLSNFLFDLTAYTVTMLLIILIFAAFQRSEFVGGDAAGATFTLFSAYGFCSIATAYLVQFCFTTHSSAQSVVMAIGFVSGFLLVIIVFVLQLFSSTREASHKIRRVFRIFPTYAVGEGIVNLATLPQFHLSDPSLTAFSMEVIGWPCVYMAVEGPLFLILVLLIDHPRWRLKWLLRHYDPNGDAATLARAHQPGRQDDVGGRENDSVEEDSDVEDERVEVRRRMAAYRADLMQQERMCRMGDCFEPAFCERASVNAAEGPYGGFQSFSAKPPLIDAVAVVGLHKRYEDGRVAVQDLTFGVVPGEVFCLLGTNGAGKTTAMSVLCQAAYPTAGHVYVCGHSIVEERRDALQCIGYCPQLDATLDLLTVEEHLKVFAGIRGIMREQQQQVVQALLNLTGLHEYRHTTSATLSGGNHRKLSVALSLIGGPPVVVFDEPSAGMDPVARREMWTSIEAIKHRCSVILCTHHLEEVEALADCVAIMVDGRLRCIGNKVHLKQKYGSGFELTVRIQPPSVAEAETRGRAAEEAALEAIKARVIPFITSSFPSSKLSEVRGKRLIFTLPKDTSLANVFQRLQAHRTELCISDYTVSQTSIEQVFLHISDAVAEEESACAALSERCRDAESDLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHP9</accession>
    <name>A0A088RHP9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_050650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_010705527.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22572143"/>
    <dbReference type="KEGG" id="lpan:LPMP_050650"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230027200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_050650"/>
    <dbReference type="eggNOG" id="ENOG502SJI3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267965at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        </source>
    </evidence>
    <sequence length="2401" mass="250895" checksum="48DA9F81E1D101A3" modified="2014-11-26" version="1">MEDDADVNTTSTQGSIALLSGSGSSGGGNRTESQLSNNGDMRAGGDVRHPRPTKQASKPARSQSPGGARPLVTPPPSACMPKLITPRKAVAPAELSYKVNLSNSPSPSNVNVAFMRVVQRLNSEDLQSSGSRNDHSDKRRREQDAAGTAINEVKPTNQASGELSKPSAIDAQSPAPPSQERLVPPQQTTRLSNMANTAAAAAAAIITTDGSIHFEDENSSDDGEYAMTASALSEAAPPPCASEAKQAALSPPHQLRPSPAAPGPPAALGPVKTPPGEVAQHSVRSPAKKAPKKVFMKVVVGASGIGGGPRQGTTQQQHQHPGTALAHSTMRSVTADQPPLLALSTTTGPTSSKDSIPLKPQTPESPSANPPVNQQHRTPLASRNNRLGCTASAATAATASLGATGVSAATLRMASPTNPNLFASPEEDPVCCPVSEVTMVNAVSPGSGVSPSLRGPNRGLQQIGNTAKESLSPSSDRPLLPLTAAGRQEQPAGFSLDEPNALVTLSTPHEVGKSLAAPAAAPIVADPSRHAEREMGDEEAHTLRPGSPRLPRETQSGDEGAHRSHSAASSIFKCLPFKILCGHSAASVAIKSGTDANGGGHVGEASIGSSASRPSTRGRHASGLSRLLSIFKRRASRSAQGNSAVKKQQPCQPEGSASLMSTVKALSQTLTPGDAVKTADVQTGPQRWQSPPAATAIALSANSIQTGRLSPLHNITNSSYGNSISFRMDEEENPKRGDDAAAAAPVEGACESDRVGEKQQRGKRKDDAQRHDRRRRRHRCRGAEAQDETSSSAAGVDDGRGSRCFRGTTDDVNASSSPTPSTSASCAAKHRRRRERRAQQSERANGDPKCCQARPSFPILPLESQSSDESASSDDRPDHSRRHRSQRAHRQRRDGDSRSVAASGTFVSGMGAQQRRYRRALRAFHRSGEGARRDSISHTNSNRDDYDAGDSVNRNRRGYRDSAVPQPPTTTAAILVARRRELCVKSRAMSSVDHFAMSWHTRQVKRHQQEQLLRRSRQANIAQLQKRNAERKARSEEAAVVDAVAAAASRSASRLRMLASPQPSTVKARQTSTSVPSPRQRTLCQLAQHEEVLMRDLLALDDILERRRRRELWAEASPEAAAAAATAEAETTPLHHPSCAAQCRAIATAAAVAASTLASMQRSDEMNSDNNEAEADSRRSNSTRLPGNPTRLDISVLLRRYEKLLEDLATQTAPQPPATLESDNGDTSSDVEAFVRTRLRHDKGGLNHQAASSSSKRKRRSAPTPVLVADRMTDEVALCAAALRAEYYQPQQHQQQEPSKTIERGALPEAYEACANTVPMEGVAASHAQALRPSCAACCPQQLDEYITLGLLSTLHKAGERGGAAAAESEKAVNARQGQTQPAATTTLPQRRIREDLYDAPRRGERRRMAQTNGEKPTGFDGNIAATSLITSVSVPSSAVLSSLHPQSADAAAADRDVGLLSNAGAAPSALAQPPRSSTPTSEVNYGALRTQLMRLESRTRRECVLQEQAAMHALKRLYIVETILVLRAMSETTEMQAQEVPAHGYQQQLQQQCTIASHHSPATPVNDKGGKKSGSAVLTDGWVVPSSSAVSSAARGDEKGMPSPASRTINRPKRSSSASRIVRRGSRPPAAEDPPPAQKPSSGSHRTPPVVSIDADLSSCPREESTTTVGSRPPLALTEIALSPSAQQEDHRSRSPLSATRSGGGTAGVPAVATVSVSQEPRAQAAAAPPSLSPPSLEVVAGKAGENEGSPADTRDAIRDGGNGGSPETEARAPLMTTAAQGEDKGTKHDSSPLPSPPAAATDGGDGVGQDKGNGDDVDVAQSCGNSSASSALSFRVEGDNQKGAALLQPEPSADDRGKNPHLAVASGNSIAATPTATAQPSAGESTSPATSVVDGLAMPFSTSSQAAEARPLSIDRGEHIPHRAPHGDVDDLVNNAAGTVMDASRRGVAAGLSSTAEDTSTTPCRFTLPVLPSSSPSSPSALSSPAFDLHIVEEKGGAVVAALSPDGTGVSYEQDEGEERHQEENTAVEDEGTVDAACKADDVSAKDVEAVTLDAVQAQVAPVKSTASTAIASATAAGTIPQSERPVSTGAEPRQAPDDPPQQQGKQPLPMSTAVSAPCRRVSFSLPPGVVSGGDGKENEASKASKQTHGEGLEASHDAFGRHSVTPGSSKDAAPAAATVDKDKVAADLLEKLNGLDALLLYNFPAYFTTGTDEDGLPSVVMRHPRRPSPTSSSVQPRWRRSPLASTPSATARATAGAASPCDAHAIPLRDRLTPPRLPRKSLASQLRHKYGLPQLQHQCSPPIETMASTKTRTTVSLADTTSITAAVPIGADAMEMAGVNASPSAAAAVSSTHPSLHGVQPKEPTSAPSTGSPHTTVTRASTGMNVSAAPATPLGEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHU7</accession>
    <name>A0A088RHU7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Surface antigen-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_040180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="AIN95345.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703667.1">
        <property type="nucleotide sequence ID" value="XM_010705365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHU7"/>
    <dbReference type="GeneID" id="22571977"/>
    <dbReference type="KEGG" id="lpan:LPMP_040180"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040007600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_040180"/>
    <dbReference type="eggNOG" id="ENOG502TFRU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="258158at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052798">
        <property type="entry name" value="Giardia_VSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23275">
        <property type="entry name" value="CABRIOLET.-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23275:SF100">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN95345.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="472" mass="49675" checksum="8D48C223D82BBFB2" modified="2026-01-28" version="2">MRCREALAAAVVVACMVIAPATAYTTEQCRELSRCDVGGTFVYSFSEKCVCCPEPPTGSILPVQCAPSTPLCPSVSHCKACDTTVGRCDVCVSGYVLEPITSSCTQCLASMCDICQSDSEGKRCQLCSEGYYWTNGGECYPVSSSMPAENTQCRVAFCSTCATAAADTCIKCADGYTTDSKGFCVNQCTIQNCDMCYTDNAADCQLCSTESTWSTTGCLSGTSGCRIGHCTTCLAGDHSTCVACESGYTLSAGYCFSSKSCADANCVSCPSDPGTCTQCKPNYFLTPLFTCSEVPCSIENCMQCDPQNPSRCQKCVAPYEVDSYDGLCRLSDTCAVPNCKKCAAGTSRLCAECDAGYSLAADATSCRNANPQACEVEHCNTCVSGDSTRCTSCDAGYYVSNGKCLAVRSCYVSNCAQCMMLDNTKCSTCMNGYLITSSYRCVSQNVINGAAAPHSLWMAAAVLLASVATCLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIF5</accession>
    <name>A0A088RIF5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_070610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009376">
        <property type="protein sequence ID" value="AIN95747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704069.1">
        <property type="nucleotide sequence ID" value="XM_010705767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIF5"/>
    <dbReference type="GeneID" id="22572396"/>
    <dbReference type="KEGG" id="lpan:LPMP_070610"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_070011300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_070610"/>
    <dbReference type="eggNOG" id="ENOG502RW6A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250420at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="469" mass="51597" checksum="2BC6D11C3374468F" modified="2014-11-26" version="1">MPPSRVRKEEAELRQIAKKSRLARREAQQRERKQHQRARRAAATSGEAPPAAAEPAGASVKNRRRGAILLPHEVQELRQRLLDDDTAAASSASGSGFPDRKKKKAEAKKAARSPASKSAGAAGASSHSAAFASSTLVPAYHQEVHFKKKMFFVDVVLHHIPHQKIDISETNASQLVVDTCGHTKRYRLVLPYPKGMRCDAAVATYEFENGILHCRLPIVDGTIPVDLEAENERMVEEIRQQKALRFRVTQDGDLTVRTRQALLAPTPVAQAALIETKKAAAAARRCDDADNVNDTINTKELEAEGREKAASPKSRKRTRDSGEEDSKEMQQLTNSASTGKAAGAALSESIAPKEAAAASKPATKKSKSDIFEAEHAKAMEAARAAAAKVHLSLRERVKLAKTVQANREERLKTRSLRKERKEEQRQQSFHRVLEEQKRQLVARAAMQRSVPRPTPKANASAKSVRFADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIQ4</accession>
    <name>A0A088RIQ4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_080630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="AIN95872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704194.1">
        <property type="nucleotide sequence ID" value="XM_010705892.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22572525"/>
    <dbReference type="KEGG" id="lpan:LPMP_080630"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_080630"/>
    <dbReference type="eggNOG" id="ENOG502S4UQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273869at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35614">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35614:SF7">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1076"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1201"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1341"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1401"/>
            <end position="1586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1679"/>
            <end position="1715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1772"/>
            <end position="1843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1856"/>
            <end position="1925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1961"/>
            <end position="1986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2080"/>
            <end position="2212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2332"/>
            <end position="2431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2443"/>
            <end position="2507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2524"/>
            <end position="2553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2592"/>
            <end position="2634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2658"/>
            <end position="2710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2727"/>
            <end position="2749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="394"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="512"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="592"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="669"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="698"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1076"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1216"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1345"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1356"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1410"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1452"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1533"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1547"/>
            <end position="1565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1684"/>
            <end position="1703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1780"/>
            <end position="1803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1827"/>
            <end position="1840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1871"/>
            <end position="1887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1889"/>
            <end position="1905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1916"/>
            <end position="1925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2109"/>
            <end position="2120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2121"/>
            <end position="2139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2155"/>
            <end position="2165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2169"/>
            <end position="2187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2372"/>
            <end position="2382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2383"/>
            <end position="2397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2443"/>
            <end position="2474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2487"/>
            <end position="2498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2592"/>
            <end position="2605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2618"/>
            <end position="2633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2659"/>
            <end position="2673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2800" mass="298310" checksum="0EC5FF6C1EED4F05" modified="2014-11-26" version="1">MGILPSRESHEYPGAFHFAQSGSHAMAILPLTEHFFPSVESLAFKQLYAGRDMQSAKYNFSLISPELLRKYQHRSMEENQMKEDVVMAPPAGRSKPQPYLRHGQPPGDDSDTDEKWVGVDTIDASNYSQFFKDDTHCVSPNELAPPFLDGDEEVCEELRRPNPAAHWHTHDAAKQLIQGNDNELGFVDELNYVSFDGKGGGLRCLPSSRPMSCSSSQHPRHGQTRNASTEATADGTAATVQFTPEERDLLNRFFARSPEALYNALVVEPNRGFLVDTNKEMCSLYAAEKRWKEARNIVRAYRRQYKQGAAAGNAAQSAAGKSPNSPKCQPQPLITKEEADEAATVPPPPVFLRPVPQVIMVRMSREEEEATRTAHLEEQQRIRRATGHPHPHQSGDGDTLTTLTSSSPAPTGTDEGSRDLRSPTPSLPSPLHVPTTRYHRFEDDPKYKDGRIHLVEEDGVLYMFAYNTAYVDPRLRVRQQREELLKQQHQREQKEQPEGPENSLEKGETCRSSSSVAAAGATTEGSEGSSTTEFDAAATHMTDGDDDGALCQKNRQTSSFYHTVSAFGNEEDEAGPQEHGTASMKAKDETPTHASTAAASPVASATIPAVSVTQVERNEEQGDEEKGTALSSTCSASEERQRQQCTTIFANDDDDAGPQRPDGKLTTSSDDDDDDDDDGDGDERRKDASASTQSVGMTAATPTGTTSAATEERSRMVRQLELVTAAPFILPICPVRVVGCNGYAESSCRGTPWLRGYEDDPEEDAYVESLPVKPPIMSGGGFIDANIGDKILSRAYLLGFQVYRNVCLDAGLPETLTRPFWTLGLLSNIPLLQISREMRFRMRAAAAEVELGYRGLRDMIKGTENDLQSYIYGFSDILPYLERASRARVEQAEAEAKAAAAAEGGDSSGANEGAADSRGLSSLLVGHSPSESVEDASQQLQDLPVSPAIPTRSLQAGMQQSMLFPRNEMEFYTQFTIRGNQSLSRVRCEAQESFFHLIAEATAPVSTSLFMKPLELPMYDYGGAIRLHLMCNRVTGADEIQVLPPPRNLNQLFSDHQQRLQLRRLQLQRQCCTSADDKGELKSNAKGGKESADGDSTTTAPPYLIYTVVHPSGKARGPSLEHYKRNLQAPDDGADANTLDEAEVSTAATDSTCGDGGYAAHQYTYPPDSFVDSDMVIYNIHKGRWEHFEYFHHQQLAQRRARKLQAQAEKEAGEPDSNQLPAQSNKDTTDAASVQQATTRGEACQDALVTCSGGRFAAVDEDEQDIHLEDILLCWIKRRLQSATMRNRVDPGWLRDSEGHIVQEGRYYIWGFEQDGQQYFYGLIPKFAKEKKNKRHNTIAGNAHNQHHHDSHNRRSNAQGNLSGPSSVLNSHPRPKIGGGSDVGNPAALGILSSKSIDSAQAHQHLMSGDGSTSDSHSPSPGACNPAHTAINGQMTDERGSGSMENMGVRSESATARESAKNYPTSVPTPMAVAPSVSMSDVKGGVGSEHDTGTGTPLNVVGLGSYSKQQQHLRSPGAVGGGSAHGVTSPGCGATSATTARAGRSSHPSSVNSGPRLPVQTSGAHRSSSSQQPPPPTSSAPGAASAALAGRPGMVAVGHGSPSRSGSAVAPLLSSVVIGGVAAETGASYADPRTIPQCQGDVNLARGRSTASCAQQLSNSATTAAQFSHQSISALAAAASTSAEDVRNRQRCGERRDNRDESSRASPPPPPAARQYLPHAQELHLEVHPPACPSSAGSFLLSANPVPPQQQGRLIIDPSSVILGYKGALQSRYHAPPPQQQQHQQEYRQAPPSTAYDNSSSNSYGGGSGASRHPAASHASGHSYLDMPPPPPPSSPPPPLTLAGAENALYEQPHQSYPAPVDQQHHHPRQQRPLSSSTPPLHLHLPTAYMNTGASQASLRPTSTLDGPCASPLRPAQQQQAQQQQYTSYYTGVHYQQPQVSHQASYKAQPVMASVVTGARAHGPCHHHSQQQQQMTVSAPNSGPAAPPLPPVQAHASMNTGPSRYALHPRLVTSGSGVAPMQPQQQLTSVAAASVAPPSALVGETNTYYGASPVSVAPSGSRATSYYPMSLPQASYDALSQTAASATHPAGLQDSAAPPHTGHYPPAPLKQLPHLQPQQQVHPSSTMMEASTASGQGSVANRFYPQQHRPPSPSSGPASAAPASACYGQMTSPTSQQQAYLQQSEPRNANYDGGSRDDNYSPYAASTANNNAGSSGSMNAPILMNANPNTSTSFNRVGLSLPTSAAAKAVTGGSGTSIVMGNPSLSLSPAGSSIGRGAQGYALQSAGYPTSASGSFTATPVVAVTAGATTPAASMIPRTEGSAVKVYSLGQAPQHPQQQASVGGRVAEVPSPTPHPYRTTTAAQQHLQQQQDSRYPSQAMTQSYSSDYNNGNSGASAMTTGGRPLRSVTMASDGMGSSSHEDSMMHGSRGAHAAAGEYQLPHPQQQQYQQRYPQWQPPQQLQQHHSTTSSQPSSCAPTPLPVQHHYSSQAGSGSDSSGTKSHTHAQAACTGATGKVNASSVYAHKQRASPHPQHAGAQPTPLAAAVGSGGGGGRGSVIAVAAPAAVAHVSLAMHGANPYSRKDVATASVVSPASTQASSAAVQQQRRSESYGYRPSRSESTLPYSQGSQQQRLVTRPTAATGLFHCGASGSVQTKTTMSAGSVSSVPDSHSYSLHQRQRQPSSMYVPPAPDGGYQHQSLAHPPKQQRLTPTANASGTLLRTAPGSQQRYEQLYPRQQQQKSSSPYTSTQVAADLPMQMTGSCSTYNTHSSTVGTGDATYDSNSSCSAAAQRFAHNPYSMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIU0</accession>
    <name>A0A088RIU0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Suppressive immunomodulating factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">TSIF</name>
        <name evidence="4" type="ORF">LPMP_080940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="AIN95902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704224.1">
        <property type="nucleotide sequence ID" value="XM_010705922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIU0"/>
    <dbReference type="GeneID" id="22572556"/>
    <dbReference type="KEGG" id="lpan:LPMP_080940"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_080012400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_080940"/>
    <dbReference type="eggNOG" id="ENOG502QT8S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272253at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045227">
        <property type="entry name" value="WDR18/Ipi3/RID3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763">
        <property type="entry name" value="WD-REPEAT PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="379"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="488"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="620"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="502"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="515"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="576"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="636"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN95902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="944" mass="100743" checksum="7318CB056819CBAE" modified="2014-11-26" version="1">MTSLTLREIGVTNDVAGDHDVLELFAVCREGVVHVAASHLLPDHVAVTTRNGFVELIDTATGEFRLFLTYLDRIPLDASLRCFSLVPSLYAASPQQRYRRRQHHLLYSLSYSNELLLANVETAEVRVFATCGSRPSVVQCDGDYIVCGEGNGQVAVWRASVEEWVTRHSASSAASASPLPPLWRTSFFDSTVVCANLHRDQLICCSADYRCVVACVEDGVVRATLPLDLDQAVAVFALTKPPATSLLHTSLAVCLTSRISIFTSIPLGDTATSAQFSRPLPTSTHSERWMHQGDCVVEREEVACASCLGGYLAAGTISGLVLLYSCDAAESLVRELVRFNVGYGVIGMQLFPSGTLLVVTSVGDVWRWPLGDLLRSTSASGTEGVGDELTEAEPTAATQQPPLPLAAPGVPAALSPVNNTLPTEPRAPATSYEVSYTQEGDIEDRSLSAHGTSILVHTQQRESEATAEVEETIIAESVDADGLAVGASRDAEAEGTPSVHLSTASASVRTSSASPKDDAGEDHPDERGSDSTEMDPHRTEPATVSCLPPPPLPVSSTVSEKSKERRGVGSVVRCATESQRPTLYDPEQSTEGPEVVNVSVSCSAAGDSADLSHDDLHIAVSPPSTADTTTHHDAALEGSGAEGPEAAAKGPAPGAARVAAKEGAINDKYIQTFQSNNVYIQNTADVMQDAVHRSPGIASREGAGVKASVDDLELEFTHTLKRLLGTAVGVEGLRKNRRMSPRKVAGVLANLTNQQAAAAGAKVLSHETPSHPRALEGLNSTKLLEEKRATLEAAAFNFEGYRQAHRLEVDALKYRHPLQVPTYTLQDRVFDTVESSKRLCDKESGTERGAAGNAAAVLSAAPQDDLRDVTYGKVKWTLDPRIAEERRRGGPEMAQHHCDDLIFSTPHSAKATVLFADEAPLMPSTAWEEVLLLPLPLPSAPSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJX0</accession>
    <name>A0A088RJX0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EDRF1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_101040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696826.1">
        <property type="nucleotide sequence ID" value="XM_010698524.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22572841"/>
    <dbReference type="KEGG" id="lpan:LPMP_101040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100017500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_101040"/>
    <dbReference type="eggNOG" id="ENOG502RAJM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="419432at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056582">
        <property type="entry name" value="EDRF1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15000">
        <property type="entry name" value="ERYTHROID DIFFERENTIATION-RELATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15000:SF1">
        <property type="entry name" value="ERYTHROID DIFFERENTIATION-RELATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23788">
        <property type="entry name" value="EDRF1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EDRF1 N-terminal" evidence="2">
        <location>
            <begin position="235"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="661"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="665"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="697"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1295" mass="140825" checksum="CA2094742F9452D0" modified="2014-11-26" version="1">MSNGRLPPDSCAPQNPSSRPSASWDRISVLPIYSGASSTITKLLNSTHVQRVEGVEAIPMQAPLAPGTDINQPPRNYLTVDPVHNVHQHAPGFLRNQRVALQHMLASAVMEWKDMQQNALIVSSAEAMRTIFEQVYVPERPLALRVQRIGPTLVIDSRASKPSEVREMRQQALLSKALYLMKETHGRDAVATDKAAAGAAGQLALTLPERRLASMTASDLHFGANLHRYSQVLRWRMDATEVLIGIDAPIVMDQRTSTEQLVRVKEKAQVGAADAEKRETLRYWFDAMMANVSHIGTYVHHDGILQSHHMRKTMDILDSVEARMAAAALSFTSRVLQWLVKQCRRDGGTYAVVRDYALEYVELYELPDLDESAAFVEETDKYFGCPTAAAFASASRGAAEKLADGEAYIESEVPSTTSSGYGISGSSTAPQLNRFNWSFGKTCFNIGQHLFRSGDLSRAGDALPLLHRSLRIFLPSCREDVVARETVAELVKMVPVLVARKLQVDAAQTATAVASNNTASSPKNAAASCVAGLCSSPEIYRDALLLCGRFEVPLRHMLVEAGKWEGDQLIKAFFSRCLVTCSAAVCAVVALSLEAYYCGCHHLRVLRMTRSAAKAKEGKARLRGAEHREEIMAAISSCTQDLLQVVVEGLVRLEEASALVGPPHSAAKTAATSAEARAGTSAADESASVNGTTPVSKDSRSSKEKSPPSTSSLAPARASPTDLCNQPPTPTTSPAHVSAPSELKKCSHGTSMVVVPASCSTVLDPRTQVDVTPLHSSLYELYGDIAVAAMSDAASGFSIRVLAELGTRMEAGLQQCGRKLPTTLSWLTTLKADVMSLSFTALRFYGRISTHTRRHLAKLSLVYYLVGREHHRTARYTKALEALHRAKSLLHASHKAAEDTVFGAVFGSHSMLQWADVMQQLGDVYRSVVERKLDGAFGIAAATLTQPLLIGPLHELPEDADNFFTQALNAYTQGGPDRGCRSAKVYTLLLYASVLMERFAVSGVPATHAASQRIAQLIREAEELAPSMFVQEREWQMLRLFTITSAAAQDTALARAVEEILLRTITITSASASNSCIRQNAPVTVECGSNDAADASAAKESQLADVSDAECGGCRRERLVMLPSWPMLLELQKALVCCAMVEREVPDRHTDASQSRPREATKVASTEAKYRRMLRWVGRATSFLTSVLQYCKTHSSDLQGAAARRQWQPVLRSWREQEAGVFVHRMASMIALRLLGAAQALLPSTKQQEARGAVKQIALSLEHAAALKAGGSEGRVAVQQLLRDLSALLAPFVEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RK04</accession>
    <name>A0A088RK04_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_050620</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="AIN95504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703826.1">
        <property type="nucleotide sequence ID" value="XM_010705524.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22572140"/>
    <dbReference type="KEGG" id="lpan:LPMP_050620"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230027500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_050620"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="366390at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000740">
        <property type="entry name" value="Ankyrin_repeats_(Many_copies)/Ankyrin_repeats_(3_ copies)/Ankyrin_repeat_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051637">
        <property type="entry name" value="Ank_repeat_dom-contain_49"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR 2C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180:SF45">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE TANKYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1042"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1078"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1239"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1627"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="187"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="373"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="838"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1126"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1352"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="851"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="905"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1358"/>
            <end position="1371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN95504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1891" mass="195890" checksum="DF31C55C9B0927C7" modified="2014-11-26" version="1">MASTLPQEKKWKPTKTTAGAAPHRRGGGGGGSGLGDGGTGQMREDPHHTWNQQLMEACLACDAAVVRKLIECGADPVNAREVPPPSYYTGPIIQQLQRPSSSEAGWQSALPAIDQRREVSPLREQSSCNSSSPTPVAAAAPDSLPPLVAMLLSGLNTPAALEVMKLLIQHGASVNDTFSFSTTPLAAAGPGMDASEDERGGVAAGGTVANGSSGRGRRSRSVSADSKGKQPSGKSRPSAIGAPPTVAPGAAAFAAVAGAGGAVMNPPEAPKHEERTVVGSVLHYVVAHCDHAQLMRLLLLATTAINFAADTSATLPSLPLHLQQQRTMDEAGGDGSPSLLQPSFPAPLPYSLLPAVEAETLVGVMRLLHQQHSGGAADAAGPNGSPSLAVTPGTSQPRKSRNASNAAALLRSTGTAAAAPPATAPPSAQAGGPMSAASLVSPSAAEAVLTALHQALLQRQTSTGGYRGLPILMSVYPQQQQKKEEGHADAADAAATDSAATAGVVSPAVAAAATPHNWWSLTSLCDVTGAVSADDLHQRTHLNLDLLDTCGRSAATIALERGDAVSVRLLSFYGAHVPFGGPVNASQTRLARACSNGDVARVEALLRQGDTITQLSADGRYTLVHYAAAQPSVLQVLGEHGLSMDFENSFGESALVSLLRHGTARNDPRYVQTLLALAAAVRSASTDGAMNTATTNLVNSMSSTTSANAVHFAQLSGAMQRNMILCPPVPLAALTSAGGATSGAAAAHLRVVSNSMSHGSAAQSANTNSGGSNVACQPFLGGCEVGTWWSFLPQTATTADVLDTLLRAGAVMQGFVPDEELDLPYVLFAEWQASIGAGGGGGGGSASTANGDDEAEDDGDDEAEDDGAGDGGMDGSGDAHGEDDYRSDDEDSSGADAGSNKVSRRSLSVSAATVTPASVRRDCSKRRQQRLAPVPARLPMRLTPLQHAIFDYHPELIRRLLVDYRVDPMHRDSQGATAVHYAVLCTHAQSVLELLLSPQVLVSSSIGNNKGRLSNNTGPDAFTTAATALPATHIDLNAIDMAGRTPLFYAAYVGNTTAVQRLIRFGGATLLCGKADKDGYTPLHIAVRQRHADIVELLIRHSNQLLGSAAGGGRGQPRDIFAELLASTNGGGGSTGRSLRGGTRRGSHHSPTTSSHGAGRSSSADPAGIAKLELLVNVEAEESATHMTALEMAIKAWQPTSSASLSEAEELQKGQLLRIASVLLAEAQASPLRPSGLANGGALLHRAVADGAVEMAELLLSHYADPNEANDVNETPLFLALRLAAPRVSSAEQAQQHRHRRTSLVRVLLQYGATPYAQSSANLQTPMHLAASSLGDADEILQLLFYSTPEAGGSSVAARRRRHEQQRHHRAPSNAANGTDGTSRGESYSLGGGGGGMEGSSSARRRHSGSGVGSIAGRKGLLERRAQQRRASPSSSLPGRAANASPASRRKQWRAAALSDNEHSEGLADLDGLADDQASLANSSFGYRDARNSSVTSVEQGNSDQSLRGTVGVLAPATRGGADEDVPQEEYEQFLQRLAQWQCADHLLEPEKCWLLTDAQGQTPLHVLCSRSSRALQYSSAVVKLLDDLQAVTRTNSVITAAAAGVFDGVLDDDHVLALCWRLPDAHGRTPLHIAAQSGFVEAIERILQQAPQCALAVDMQGRTPLHACVLMAASTTTPTAVTAGASGDDDDDVGDDHITQHKASKEDVAERATQLRRTLSLLRGVITADNNAAAGATKLPLQLQGAPLRRAAGDIMPSLSMKATTTRCTTGRNAAASHSSAQRVVASLVQPSSITAQLQRWQQSRHWGCPALAMKGIGTGMSTASRDGSAAAAAPASRYLQSSGGASTLSSATSEWKAYAQLPDGQGRTALLLAAEVGNVSAARELLKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RK62</accession>
    <name>A0A088RK62_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SMP-LTD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_120850</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009381">
        <property type="protein sequence ID" value="AIN96412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697065.1">
        <property type="nucleotide sequence ID" value="XM_010698763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RK62"/>
    <dbReference type="GeneID" id="22573091"/>
    <dbReference type="KEGG" id="lpan:LPMP_120850"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_120013100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_120013200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_120850"/>
    <dbReference type="eggNOG" id="KOG2238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26740at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21675">
        <property type="entry name" value="SMP_TEX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466:SF1">
        <property type="entry name" value="SMP-LTD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466">
        <property type="entry name" value="TEX2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="11">
        <location>
            <begin position="316"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="513"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="516"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="564"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="647"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN96412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="717" mass="79210" checksum="13221838C9C4F9CA" modified="2014-11-26" version="1">MDILTLLTFLYGAIGGAVSCVFLFFILFRKAEAVLSDTVRNMARKHVEFDAVAKEAVAVAPAKVETLCKVVRFDDGIVDEAIQCRMVFYSGTIDIYQVDKLRTLPDHRQEVVSEHMLGRIHRACIIATAQRISKYHRHRNQNTRYAAIKGRCTVLNHKDGMPLFLEDPNTILKKKLQRVAEQQRQEAMIESLFHRGRCDSKAMANEEFSAEMKHIESETRKERHSYYTMGANGRGNRHDLMGMDAATTISSGAFHQSGSIPGCRGKGLSAGGLGEVPLSQWRCVAIKFPTRRVQERWLNLLQSTPQSTQWQDFITHLPQMDVFNLLIARLFFENTRANTLHDLLEEKIKKKLARVSKSLPPQLRGNIFLDGLDVGGEIPLISNVSDPAPSKSGDTEFDFDVLYRGGLALKIRFSILYRDIRVPDIIFSIKVLELAGRVHFVVGPPPTRKLWLGGPQPPQLRLEFTQEVASHDGILNAVLRLLPDMSKIASNIVKVMLFEDMVFPNMDDFPLPVFGEDSDDDDDDSATVHNGVEDVANERNTSRTHLGSSRSGDDNEAERERQDSSSCTAGGAANENSGSQSGVTPRKGVTPPWASLSSAPAVERSAHSQHVAFEMTSPPPRPPIPHSASTSGKAAPRAHPDGHDIFSSGRRGSTQSSQSQTLRSLPGETSPLPMRISPTGLPPRPPRAPSSELVHRAAPQVPKSRAPLCNQALLGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKB1</accession>
    <name>A0A088RKB1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">mRNA (guanine-N(7))-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_110490</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:67008"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.1.1.56"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.56" evidence="1"/>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696898.1">
        <property type="nucleotide sequence ID" value="XM_010698596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKB1"/>
    <dbReference type="GeneID" id="22572914"/>
    <dbReference type="KEGG" id="lpan:LPMP_110490"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_110007800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_110490"/>
    <dbReference type="eggNOG" id="KOG1975">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10248867at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004482">
        <property type="term" value="F:mRNA 5'-cap (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000470">
        <property type="entry name" value="mRNA capping enzyme-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004971">
        <property type="entry name" value="mRNA_G-N7_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039753">
        <property type="entry name" value="RG7MT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189:SF4">
        <property type="entry name" value="MRNA (GUANINE-N(7))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189">
        <property type="entry name" value="MRNA GUANINE-7- METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03291">
        <property type="entry name" value="mRNA_G-N7_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51562">
        <property type="entry name" value="RNA_CAP0_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MRNA cap 0 methyltransferase" evidence="8">
        <location>
            <begin position="794"/>
            <end position="1044"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN96245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1060" mass="118371" checksum="A8735B6522DC86D8" modified="2014-11-26" version="1">MLNANAKAFIPPGVIEGAPPSFHTIGWYRYCLSVPVERKMSALHEDSYLNSISSLLSLRYLYADRGGLDDDSLQYFINGQFIMSNNIPSSGDEEHASSGFLLSRSILTLYTDLAAIKHLNDSRGLLVHLDLPTEFNGDVSIFLASAWEAFFAAVSENPSVSAVGYSRSVVGMSGNQTNGTYRHYFFAACALPESLELVIMGTMSEFPVPVARIVHMKSVVPYLCSPHLQLGVMITVGDEAKRSAIKDRNVDFSLEMTYRADNFLEAWKAIRNIETHFLEALNRDVKWDRIHILHLHIDPTPTENPVAIPIWDIVWFIGLLCDDCSASIIGVSFSTTALDSPTKELVSRNKSAPFYVCSNLDAMLVANLSLDTKSTYYGGVPSHVKTVLPCWTWEPAVSAMELWQRARKHLSPVEMLTRMSFADAADSFARGIYTVHRKAVGTPIVLGTDSKGNIFGYDVDHNSVFGLPLCFGGTVDPVISCVFKGTLSSSYRSSLDYRIIIDDILLFKGKETKGIPFAERMRMLSNLGIEDESTWPHADPAHIVILKAECLPLDSSKKLVDTPVFDHSNMGLVFTPSIQPDDNSVFPTFVWVPPTSLTVRFVVENIVVANEMNEGFDRAYLGVSSNNVDSRIIIPYEGEFADYQREAYPTLGVGSIVECLLRRADDGAHWWDVLQDFDIAEKYEADSFDHVDELVHSPGVTQEEMLWLLKAPSYQCERCHKVNDVGRRNNRHNAYWCKNCWIETGHGDCVYCGRTFVLGMLDGTSNFFYCEECWRSFSTFNTDAEIGYHVPPPPNATFTQQVTTRCVSLLIDLMNPKTPSNDILDLCCGGSVARKWMRNKTSRYVGIDLKRSVVDAITSLICDSKEMPPEARYDVICGDVFSEDFWMSTIVKMHPRQFHLISCFAGLHHAFSSEEKARHFLGSIANALVPGGTFLGMFIDASVLFAKGKTYANSIMKAGWSVDSVPRIGHTFQFTTNNGPMRDVNVIPIDFLIAVASEYGLHAVSEAYLTFRELIEKDASWTKVPSTDEKEYLCARRTFAFKKESNELTPSSPARKSDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKF5</accession>
    <name>A0A088RKF5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_130780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697160.1">
        <property type="nucleotide sequence ID" value="XM_010698858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKF5"/>
    <dbReference type="GeneID" id="22573188"/>
    <dbReference type="KEGG" id="lpan:LPMP_130780"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130012100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_130780"/>
    <dbReference type="eggNOG" id="ENOG502S0YA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="243277at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="328" mass="36297" checksum="163483067F6040FE" modified="2014-11-26" version="1">MFKQRDNEYHSPMTVDPSGAGATTSASLLDRVGTGKVASPFLDGPAVAAGSRKRGRDIRGLDRFRSVVYGEDGFRRLHAMVARNPVLMYPPDGIEAARARVLGRKAELQSALDRNAHNRGPDGDGDDDDVFALFEARQRAEIDAHRAAEDEDESGQRASEHAPQPSSLASICHDNELATHHHKQLDSYLRLLYEFNHVTFAKLPMEDTLQLLSRCGKESVAHIVEYETQVRLRRQSRIRELDELRQEQTALEGRHLAAEDAEDARVVQFAEQRQAELDLELDKDVTKAVPLDDGNADEDVTAIPETDVPSAHLTAFVVDGGLEGDMGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKL5</accession>
    <name>A0A088RKL5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_120420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009381">
        <property type="protein sequence ID" value="AIN96370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697023.1">
        <property type="nucleotide sequence ID" value="XM_010698721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKL5"/>
    <dbReference type="GeneID" id="22573048"/>
    <dbReference type="KEGG" id="lpan:LPMP_120420"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_120009100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_120420"/>
    <dbReference type="eggNOG" id="ENOG502SI6Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266276at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="365" mass="38284" checksum="2B54AC648C63EA39" modified="2014-11-26" version="1">MSSTSSCSCSSDADPGIETNQPATHTTFASVGGHFMTELHISSVAAATLSSSASEAASPPHGAVYDSPRYLEGLFADLDARKATLFASPPCQKPAGDVDLALGSLVGRGEALGSSASPKIVPLGSLRSYANEAVSLSPIPSPAPVPVPETVATSSYATYEGERLLFVNEGVMLSTRLSSPGRGAPRAGVERVDIANHRPVTSTTGARMAVPTQKSRIFEWDEEVRSRRQASPPRGPGANRDEGAARDDTEAQERGEWVADAECEEARLVQRAMKAALMVSTSPHAPTVVHLHPSNPFLDPAVNSSEETVPGYFIEGISSTPAQADSDVVHLTNGLVTVTPMDASDLRRQVGHSSSPPTQPPFDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKQ2</accession>
    <name>A0A088RKQ2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_120830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009381">
        <property type="protein sequence ID" value="AIN96410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_010698761.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="22573089"/>
    <dbReference type="KEGG" id="lpan:LPMP_120830"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_120012900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_120830"/>
    <dbReference type="eggNOG" id="ENOG502SMJH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264833at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="568"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="906"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1122" mass="120515" checksum="9D8A36FAA69D9C15" modified="2014-11-26" version="1">MRHLLLEVKLPFMDVYLVETYLFHPTQYTHAIQAIDERSTSDARASMDQTCRKHNIRSDVTRQPPSKLPGVELESTPATRRVTSAAVSPSPSDKVLKDAKHVGSYPFKGPERVSERLRGGLVEKAALAETPPRRTAMRTTTAQAGRHTGALCLSPSATDPPDSNKVGVMNCADAGEAHPHPRPPLPRPPRSDEGPRPPARIAIVSRSAPTESLAPPQQDAPTALPLSLLRTMECVLREYKAALAVALRAVMHREAVWTALQQFLHVVRSDWAPLGARESPLVAPGSSQPCGRSNGAADGTLGSSGISGALQLLRSPRESGVRSGNMAGGTCRAEALPSPRCTLLGVSSLKSAAESECGTVERSSTPETLATLQPPTELTGTLVHRETMRSSSAPSLNRTTAPADSANRHGDAVVRTADCEIERHVATIVRPPHAAGSAERGRHPRRQQRTSLCLSVEVLQYTSAKFTGGAASAETRAMEGTPSYHHQSPPARTAPLLLRLPTSTPSPSTGAVRDVTGRLASARVRSAAAQSLRKLDREDSRLSTGEERSMHSVVAHRTLAVRHVFPALSGAPPALCPPRSAAASDGTRRRSQSAPCVAAAALHSPRPQPDSSFDVTPRVQITSRCDDEAGAAPSRTARSASDRGTPMAPRAARAYRSLQASPASPGPRQQESHGGPLVTGRSKSECAPRPHGGVVPSLGVRLHAVSRQVYAACLYHYLFYLQRTTLAVVEAVDELRRDHLTHAAPFVVEHRNYLLEVLMQTSTLTRDAAVKWLMHEATVDDERDSKNGGHEFPVAGQLSVLNSGAPHHTTPVPSVAQQNCNHAPDAKRSTYELLCTNSSRQSTAELTQDAEESGERAAQRAGQLAAARVQWPEQLLQSPLMSTHANLARYAATPRFLAQLESAQNTTPRAGANATVDTAHPSGADRGQYTVPLSTSPTLATLLPLRLVLPEDVLVSYSGDAATPEDERNRKRSASTRAVCLNTVPPGTALRKRLESGEHLLHLEVAAQLKYLQTCMQCALAHEYPLYLRGMLEVHRRFFEGTKSMAGLCGDAAGEVCATDGEKVDAAVTSIGTPATHGRADVTTARVRYDRVLLKDELLRADWMKELQMSWQLLMSGSSSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RL59</accession>
    <name>A0A088RL59_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nonspecific lipid-transfer protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_150280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697405.1">
        <property type="nucleotide sequence ID" value="XM_010699103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RL59"/>
    <dbReference type="GeneID" id="22573444"/>
    <dbReference type="KEGG" id="lpan:LPMP_150280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150007800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_150280"/>
    <dbReference type="eggNOG" id="KOG1406">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="542135at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00829">
        <property type="entry name" value="SCP-x_thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055140">
        <property type="entry name" value="Thiolase_C_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870:SF2">
        <property type="entry name" value="LIPID-TRANSFER PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22691">
        <property type="entry name" value="Thiolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiolase C-terminal" evidence="1">
        <location>
            <begin position="204"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="348" mass="37484" checksum="61111AA4AC40CCB6" modified="2014-11-26" version="1">MQAHYLATKFQLTAANPAMLLKTIDTGGASPISSIGAALDLFRRMPHLKIAVVVSSDAVLTLPSSEFAKRSNKSVPSPHLAVPHIPHGYDFFAQWQMKRYGLKREQLAMVPVLMSAMSARHPDAMCRKRYTLEEVLSARQIAPATSLLECARRADGAVAIVLAREDHYQQHIATGPLDGRRPYVLGVGEASGPLYPPATHEEVTPDTFSCHRAVRLAYEAAGGLSAVDIDFFGLYDCFPICFIRALEATGLCREGEGGQMVEEAYRRAAQRGGDVNPSEFPINTHGGLMCFGAPWEVPAMYNVAEAVAQLGGQAGPRQVHPTPRRALVYGNGGVFSASAVAILSTDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RL84</accession>
    <name>A0A088RL84_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_150650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_010699138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RL84"/>
    <dbReference type="GeneID" id="22573485"/>
    <dbReference type="KEGG" id="lpan:LPMP_150650"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150010800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_150650"/>
    <dbReference type="eggNOG" id="ENOG502SIYX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267360at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="567"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="662"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="577"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="686"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="703" mass="72403" checksum="994C26C37FCAC848" modified="2014-11-26" version="1">MSSSSIPREDSQGLQRASVSPVVTPTMSPATIQPQHQQQQQKSVKPAVTMNSPIMNTGTAPRLLFTWDPYRNVSPSPGSTGTATSGAAAKPPEEEVVEEGRLASSIGGCSTTSSLNNNTNVGAETPAGVTSTTRGTNNSALPSPPATTGGARPPLTISALLGGAVYPNRGSPPPSATKASLSQQQQQILHQSPLSEACIAPGSALSTPSGPVLKRIPTSAKDGRQYFLDYSPNPMANSGSPAALAAGGMPNLMLPPNLSPVTVTSPSVPAPSQQRLQSPAGLEMLDLDGNSSANIAPQAVPLMSPPRSSSSNAGSYQSYGAVPTANSHSVLSATPLPPMGSMSQHNPYRTPSIFYATAHNTSPTAQQQQSHVLPHQDIDDNDTDLVYALESDPSAFIIRLLPPPPPLPELARVLTVPGVVQSLCARWCAYVAAVLKSDAFAAITAAPPPPPSSVTMSREGSNGSTREELTAWYETAVDWWEKLEQEGTGAVDVRAKSRTVAAAVEAVASGRSRRPPSQSTGGNPNSGRYHPQGGVGASGYRGRGGRGAGGGGYHAGMSAYGYASNTTGHRGDAHPRGGSATAAGGMATGTHNTGAAATAYRGGRGSGGGGASYNYDAAMSGGDTQHDIPDEMGPAMHCNTACYPSSNFNPYAESWHFSGTTGMATGVQPQQQQQPMHSSYVKGGRPSSQHPHQQQRGYGAMNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLT3</accession>
    <name>A0A088RLT3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_150480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697423.1">
        <property type="nucleotide sequence ID" value="XM_010699121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLT3"/>
    <dbReference type="GeneID" id="22573468"/>
    <dbReference type="KEGG" id="lpan:LPMP_150480"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150010000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_150480"/>
    <dbReference type="eggNOG" id="ENOG502SM6A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268043at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="718" mass="75486" checksum="D37711B693646A9D" modified="2014-11-26" version="1">MWRRSTNSASPRSASAERLEGGGGSTGCTIQPGNDPVAHLTNSKTTAAPAAPRTSRKWPLRSLFSSAHGDSDGSPNADSARHYQLHKKSDSTNDHGDNTAWPELPLSSSHTIIEKGRATKENCQEQHAHTLVVGQSNRRSNLPGMAQVRQRHGVLAGSCHPHASDASPLARSVHMNMEDWSDDDDWGRPTAVLEQQTLPALPRAKVPVEAGTAHVTGSDDVFVSDVALAYPRHGQTPQSVAQELTYTSPCVLPSASTPPQQVSASALVSTSVVMAAAGGPPAPTQPCEFSQTSPPADCSPAPAAFHSGIRGLRSAHATSGSGSGAEGAAVDRTKRRKKGVGAVALLSPAIPPHAALPPTPCAGVRTADQDDAAAVALAAGTAARHRFAWEAERSVERQSWVHAVQALLMQIYHACEGDSPVLAEANGNVVLPCATVTEPLHVARQLLDTARKNAASSADSTDRDGDAVRSYSTVVRMLAAHTQMGAARVDDGVGLGGDQRQQAGQHVLAMWQSISVALPAMWHQAWASATEKLAGAKQPPGGRSLTTTMECEPVSEARRTTVALGTFLKQTLSRSGPLFSVREVHAGVVAGLEAALESLIATTAAPAAFTAPTRSEMSPWAVEVVTAAAEATIHRDEMIKQCVVDIASTAAAADGCNNADRAMHKARVQLREGSWALWYVLRVVGLLLWWEAMLPHIFPCRPPSTHVHTEASTTGALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RM18</accession>
    <name>A0A088RM18_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF2779 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_110380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696887.1">
        <property type="nucleotide sequence ID" value="XM_010698585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RM18"/>
    <dbReference type="GeneID" id="22572903"/>
    <dbReference type="KEGG" id="lpan:LPMP_110380"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_110006200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_110380"/>
    <dbReference type="eggNOG" id="ENOG502RXC0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272066at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021301">
        <property type="entry name" value="DUF2779"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11074">
        <property type="entry name" value="DUF2779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2779" evidence="3">
        <location>
            <begin position="765"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="585"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="859"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="988"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="48"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="585"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="859"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="870"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="993"/>
            <end position="1005"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN96234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1127" mass="124234" checksum="EE6BFBD44A2273D1" modified="2014-11-26" version="1">MFKKKIASVATAVVSAPAATTAPATVKTTASARTPAKRDSQAKTLALIAKHRKILEEAKRQKAEMDQLTLEQGKLQQQQQFRQVKPASPSLAMPGATSAAAVAEDPSRDTFTALVDHFLASTQPLADLDETIQEADSPDDSPGEAPFKLPPPQQTKPATTAASPFIITHRSFAASLVCPKKLFLLQNRSDLIPKASLGDMMRFDDSVGFNELVRRWDRLQFGSRAVLVKENEFHQAVQRTEQLITTYFQGMYRSLGEQAPSLTIHRPAFAVEFPCTSHQTRGDDDGASAAAAGSATMELRARPAVVRYRPKENQWIFLESQAVIDPISTPGRVSNSVQRFHFTTLCFRLWLTQPHLPIEVRKKFLQVNLDNIMSENSRGRSLESSARAAAPIDLKRSGLLHIRQFFPGPATLVDCDPPRLVKFIQRVSLEELMAEDCKYYGKEGRGRQYGNAAARAGGGGGHYFSHCGLSGGSGAFDMRNFSSAIASDPLLASRAAEVELAALELDGFHNARATRSQRHKDEAHHRLFEAEQCFVEELLRRHTLPLVKSHQEQMAASSLAGRSASSPLTAFSNLLGDEGFVRASRTPEEADDRKHGKGQKLAAQKVKGVAASSRGKRRAPAADEDEESNGVAENDAGNVAIGSGDNIDSPRYARYVGPQCLRGGDACPFFTEGLCLPRKVENAILARDNHLFTLPSASLARKAEWWAQGKRTVLDVLAAYERGEGGVRLSSPQVRYANALRQGKVALNPKEIDAFFGRIRYPLFVIDFEAVQFALPPFAKVVAYQSVPFQFSLDVFQYDVLTETPTHYNYLHFGKGYSPNADPRPSCIAELIRIVRLEREKKRKAMEESGELERIASERAAKEEAEAGRRPRRHCKAPKPPKITKFNPLEEPLQPYDGCFMAHFASFEKACLEKLGQLEVEYKDEIKSFCFLDTLDLIKKGYLHPNAHGSNSLKKVLPALCPDFQYGVFGSETTAAVMMAPNGPVLGVGSGGNSASEPDTSSSKATVGEGQDEQKGENAMGVYRLWHHMEGGGTVQDLERAKLSLGGGTQQSPNWSGSAHTSITKKERDILWQTLRIQLLEYCSLDTKALYEIMREIHKEREAAAEVKPLDKTGWVFIDPVPREVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RM29</accession>
    <name>A0A088RM29_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein kinase, putative</fullName>
            <ecNumber evidence="10">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_110530</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="10"/>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696902.1">
        <property type="nucleotide sequence ID" value="XM_010698600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RM29"/>
    <dbReference type="GeneID" id="22572918"/>
    <dbReference type="KEGG" id="lpan:LPMP_110530"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_110009300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_110530"/>
    <dbReference type="eggNOG" id="KOG0198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="195"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN96249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="576" mass="63418" checksum="4A4A76C01B543C86" modified="2014-11-26" version="1">MLTGVGVSAVPPSEAQQGRLTNMDPSVYAVFEECRYKSLLSIYHLSQIIDFTMCGFSESTEVADSAAHKGTHYHDCGLHSEASTKREELVERLVADAAISSGRTEDLPLFIPFMDDNSDASFYSMVHVEAESSSNASGLGCLSENAAKDQSKQSTALKATSPTALGSGERDVSLFPHFNGHWECGIFSGKRVYIQTGGFYLGRGATAMVYEGWMAVTDTVNGSEVYLAKVPVAIKEVTFNAKESKVRNLYELALKLRLDMVHPGIVHSYYAGTYVPRLADFCRAEKAMLYAHLVLARSVTGSVADVLKRTGPLPESEIKRCMAEILSALQCIHEDHNLVHNDVKPHNILIFDDTSAYYADFKYQITDFTGIAPATPIADVLRDLDAQLKQYQSIFSEGGTVIYMSPESCLGMATLTSNDVWSLGITAFHMATGTLPWGPLERQYPSMILNGYRQKYTLQSLVDMEVKRAYEASSAYLTRASTPLDPDSDDKPRVRFHDSSAAGSRAAGGDSCTSQVFRNQYKGFGPILDVLDVVSISSEFRSFLAQCLIENPVERPTCRQLRSHPFLRDVKVALQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMM4</accession>
    <name>A0A088RMM4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Actyltransferase-like protein</fullName>
            <ecNumber evidence="2">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_130500</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="PLoS Negl. Trop. Dis." volume="10" first="E0004326" last="E0004326">
            <title>The Dynamics of Lateral Gene Transfer in Genus Leishmania - A Route for Adaptation and Species Diversification.</title>
            <authorList>
                <person name="Vikeved E."/>
                <person name="Backlund A."/>
                <person name="Alsmark C."/>
            </authorList>
            <dbReference type="PubMed" id="26730948"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">L967/96</strain>
            <strain evidence="4">MHOM/PA/71/LS94</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KM411753">
        <property type="protein sequence ID" value="AKK31202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KM411754">
        <property type="protein sequence ID" value="AKK31203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697132.1">
        <property type="nucleotide sequence ID" value="XM_010698830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMM4"/>
    <dbReference type="GeneID" id="22573160"/>
    <dbReference type="KEGG" id="lpan:LPMP_130500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130009100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_130500"/>
    <dbReference type="eggNOG" id="ENOG502SJ4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="329272at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="197"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKK31202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKK31203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="277" mass="30866" checksum="6CB294E4B6D2DF0E" modified="2014-11-26" version="1">MSSTSSVDVNSAFPAMQDSADAVQWTKLDGAQKLLANHSDAKRFFTKYTMLRTVVGEVKPVFYDSVRTRVKVLCEEKAFAAGEECDDLEAVSMHVVAYFHYRLFMEEMKELMAQARLLKSIGMEGSGLRFQPREQNIDASGDKPRARSSCRCGEPSVKVQLHELSYCPAAFIPVGALRLRRVSKVSETGEFSEIVAKIDRVCVVKSVRCFDVGRVLMKAAEKIAREAFHVRWALVDAQLSSKGFYAKIGYAPKAVQTCMELHLPYVVMAKCLAEASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMP5</accession>
    <name>A0A088RMP5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_170720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697763.1">
        <property type="nucleotide sequence ID" value="XM_010699461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMP5"/>
    <dbReference type="GeneID" id="22573815"/>
    <dbReference type="KEGG" id="lpan:LPMP_170720"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170013200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_170720"/>
    <dbReference type="eggNOG" id="ENOG502SBT5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="246526at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="285"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="525" mass="56687" checksum="595D68D7A7F483BF" modified="2014-11-26" version="1">MRCSDLSLLVGPHTNHDYLPLSDALLYMPAVLLRETREVVLEAEEGFTKPWRVQDQQREDTLLHLLELRRRKLAAVAQLMAELRQVDNQLLHITETKALDVANWRYQQRGLHRKMEKLLRGATALATCFAPVCSSPTDASAADVDTGKSQGVATACPSGSHTQSVTQKELAQVRRILQVQLAQLEEEKYASAQRLETWHQLLSEVPWGGSASGDFSCAADTTGGEKDSTQHIRPSITTPSAAAAGMIHTPAHNPPPQPRSHHQERWHASEVAATSAPCTSTPGAPLHQQQQTPSLPSSPETDIAVTNRRSPHPSDAEVVLLQHALHNINGALRQRLLHAAAASLSSSSSQSPPTSHYAFAREAAAAADVNISGLPPLPDATPLRGSTSSNVLSPCPQQNSTHPGSVSVTAAAYVIQPAREQQQETSLLPRCAEAMVPVTLEEGAAAAAAFHATEEAQRRVWRQSLQVREQEMKDSLNQLLHSTKTTSSSPSRERGSVGSLDDAGRPAASAMCSSIPTYQRSLESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMT1</accession>
    <name>A0A088RMT1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_131160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697197.1">
        <property type="nucleotide sequence ID" value="XM_010698895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMT1"/>
    <dbReference type="GeneID" id="22573226"/>
    <dbReference type="KEGG" id="lpan:LPMP_131160"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130016400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_131160"/>
    <dbReference type="eggNOG" id="ENOG502SHZ6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266291at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="719"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="865"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="874"/>
            <end position="885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1071" mass="111946" checksum="31CB51F877861303" modified="2014-11-26" version="1">MDGTREQSGSCTSVAIARHAASPGPLSMSFRTAGIELTGATPVMDSVGAFTTIAASTRRHVSPTNRDTSTTASLGGGVGSAGGYAERLAPSSHSVINASVPPGASIAGDNHPSSGTLSTRVGSAAATTRTVAVESHLTAAQNGERGDKGNITSRSHRGIFRGEATGTATAKVLQRPVTVTTPQPRPTSSTPSESSSCLAMEGSSRGFDQVPQQGQQPVSPGRLSSNALLSTGVPVQHLYRVPSAFYAHNGVTSSAALSIVRGRCDRGNTFTVPAPSYISAEDTAQTHVRRLPGASFSSSDMDALEERARRAAELHASVDVGDETETVLAWAAESRSGKTGRVQVPVPSSLSAVRVARGYRRSRCRSILGSEDGPPLDSGSVSLVPGPKRRRRHEGVGGSVYVQPYQRLSNTSIRDDGGTPAVPTRWLTSPSVSSSSSIVFASPQSPAVALASAATSTSGISASRPRVAPSPFSAVLAFFGAVPSRTAAMTASGTGPFLRTATTPPTEPPAWVRPWVLHTLSRAFAAHLARDVDASVAAAASFTSTPAASSAGTVTQSLHSSLPVAFYASAQATETSASAQPRTLRAALLLIFDGLERLEAGLAEVLVGRPNACHSPDAGHGVKVDDCRVSPRVRGRVPRAPSPSSAATAAESDASAGFVEQLRHLTRQWCEVLSQWPCEVVTLGYVEWWLGHAIWTDLVTCAAAARVALSAFPATSEAIAEQETRGREAETSNGGEWQPPQPSPQVPAFALQGILAAAATEGMRTLLDALVDAFVRAVSDLLRSTDAVGQPRSAERSASCRNIQVEIAVAPITKAQHTCMALLRLFTSLYASPPPVLQQLLTLIRGEDCFSSTVTGAAAKGDARATTLHDDADSPTSPGSLSTATAAAVAGEDLRQRPHPPPPPSSSSWLSPRGAPPGSPFASVVNLSALDASQLRSRVCQLQYQLLYAVCRLCNELPMRWQPQDCTRDAEEGESSSVRASSATYMEFSPALRHQSDCEMARLSLFATAARLAATVSALLLHVQLPMKGDLLCVAGRLAQWRAALLRSSCMNEREYTATMGHLCALMTQAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMT9</accession>
    <name>A0A088RMT9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_180270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697861.1">
        <property type="nucleotide sequence ID" value="XM_010699559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMT9"/>
    <dbReference type="GeneID" id="22573917"/>
    <dbReference type="KEGG" id="lpan:LPMP_180270"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180007700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_180270"/>
    <dbReference type="eggNOG" id="ENOG502QWT1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272836at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="405"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="11"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="705" mass="76092" checksum="87326B37B80F5B2B" modified="2014-11-26" version="1">MSALTTVTELRQQLEAERDAHAATMARLAEQIQTFQAVLTEQQEAFTDLITRVTNLRVAKGECMAAQATGHTPNMTFNTGSDLLDGLLYSLQSKLEDPTSSVTTSVLQKLEGAALEALTPYEAGRISSLFTSNTSAVRTTGLLVLFPNDVRGVRQWARKHLSSCASCAARQAQQPAWTPYRYDSKGTGFAAAPKLRGIPNKYYHHVALSLLQERSIADRMETENQLVIMRTTVLAHVQSAKTRQPLADAAATCAQMTRILQAFLVEAVAELRNTIRTSAPWNSATNPNSEFSAAVEIFLHMVQPRVQVQPVRQAAVSTTGAPCTLLQIEATVSVPLHVSALAPLLGLLADPVQRGYVIEHVLTPLAQRLGDALGSGDLAARYTAIGLQFFDGLYRIAAHQGLTETAGSRSGGLSTNRQLPTSSPGAKDGKGRTLEQLYVILQALAVFGTSVDVEFITPHAPASQVEPKQDAKKSALRLARALLLQFAAPSPLRVPPGDDPDSTNMTIKVSRAPTTFLGILNRTFSSNHRLPSTSRSTALDAFMSPKSKISLGLKLFSELVVEVYRPYHPCTGVILAVENGVGGRPRASACVPVIDLPPDVVAANVRVATYVAQRLQGLQELETSTVIEEEGQLEREGKALLQRVASALQQAAPAERLCREWAAAEITIEGVPQVCVDVVVPFRMTEVDVQSATKPLLYLHVVYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMX6</accession>
    <name>A0A088RMX6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_180870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697921.1">
        <property type="nucleotide sequence ID" value="XM_010699619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMX6"/>
    <dbReference type="GeneID" id="22573977"/>
    <dbReference type="KEGG" id="lpan:LPMP_180870"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180011600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_180870"/>
    <dbReference type="eggNOG" id="ENOG502S1ZC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="242102at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="542" mass="58344" checksum="E7497E75384FF174" modified="2014-11-26" version="1">MLRLLSLAAKVSTAVVVSLLTYRGVQLYFKNDITIYITEVVHLPTAAVQRGRQSSPKSDENLSVIIEGTVEMETCVMNSYRLLLKLAGHVRSSLFDANLNSTSLCSSRHRVLSVHASNATVDDFSFTRLSDNYGLSASSSHHSSGGTQRHGPSLVITNVDPIVDAYEADATGALVFTPACVGDGVLCRFTCVTSIGATEDAGSAPGRSGNFSSSLTPASSTVLSPQPSGNIGLGNIFVRSCFLGSDGEVAYGQRLTIELEFIRPVFGARVLIRLPSRHCRLHHSHTGGVGSVTQLLHQPRKCVWDIGAVSEEMCALSCNGTATLGSAEEVMEDNLVRSAVIPAASLSSVAKSLARLELVFEELPPALSFGEDGEEGEATDSADDNDSQFSSTSNAGSGVTHTPRRQSANARFISTQRCVSSTRRALTPMGNTTSRACKREERRRKANEKAARIQEGGNSISTRATGDEGVPTVEVVYSVNHLLSGTSVKKLQIVEERPNWTPQSRLDHLLIRRLVPGLEKLKLKKYAHYATWFVQPVVVSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RN69</accession>
    <name>A0A088RN69_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_200150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698214.1">
        <property type="nucleotide sequence ID" value="XM_010699912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RN69"/>
    <dbReference type="GeneID" id="22574222"/>
    <dbReference type="KEGG" id="lpan:LPMP_200150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200005500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_200150"/>
    <dbReference type="eggNOG" id="ENOG502RYHG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="245628at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="800" mass="87977" checksum="EE454931EF420020" modified="2014-11-26" version="1">MPRRPCASTSAFSPLSVTVADAPILHHSVGSAHMHASCLLRQLLSNRIPCSLEAFVSLTEEWWGLVDRLVQVPVVASDVGQLLVETTHAEEFQRDHSRAELEEKVIAQWEEWVWSSVPRTVPTPAALEAARSDDTPPLSPTDILSFTQFADLLYSYDRYRRGVRWGASRNGGDWVSQGGAAAAAAYYRRRYFLHPWHGMHCPVGTAQQMPYVHLLQWMLARKGSSGEASPAAAELWERYRAIEPFQPSSSSFKALDVCCQSGYVLDLLIRAGAGVVVAVDADPAALANTESTYHEYIREGGGRRRNAVLYTRRCEGLPLPTAMRAGNSSSNTPSTPQRGDAGADVGAEVQSTSASAAERRRRRAREEGRGYSGLTWLKEEGSSSGVESADATAATGPFDVLYIHPPSAVSTWPVVAAEQFNLRKTMWWHRLTHSADAEGLDAGLLLPYLPCSAAPALTRHNPLATRSGLERALDALRADVTGRSTAPSPSGDEAPRGGALLTDEGYVMFVLPRAHGTDLLRREMPGECSLADWVVAQLDGYYDLILRRRCGTYASPSTSNTAQSSKAVEGMLLGVFRDVQRRVEGAASDVSVKWAAELQRISREDMWHDVLVLRKSRTMRRRCTAWRTESLGQDRAATTSAVQWEDSFEYNEYCPRGAVPHTSHHWTALVPTYSYLEKDFYESPNAAQNFLAVGHPVSANSAVPTGYGVPGSATLSAPAAREPNQATDGVTDATQLASANFNAVFSQELRTRRRSKLRKLALSPLQRQEWYIDERLVKSSAAKLELLNELSKWDLKDYDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RP38</accession>
    <name>A0A088RP38_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_201940</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698395.1">
        <property type="nucleotide sequence ID" value="XM_010700093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RP38"/>
    <dbReference type="GeneID" id="22574403"/>
    <dbReference type="KEGG" id="lpan:LPMP_201940"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200024800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201940"/>
    <dbReference type="eggNOG" id="KOG0925">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000068">
        <property type="entry name" value="ATP-dependent RNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001148">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15/PRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF109">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="80"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="257"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN97688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="765" mass="84529" checksum="30E23C5140CE8D7C" modified="2014-11-26" version="1">MVTAHLMALKRVRSEATENSEVGLDDMLVSQLAKKRPDVATCTSSSAVSPFTQQPFSARYKELLMARQRLPVFEKRHLIQETVRTHPVTLLVGETGSGKTTQVPHFLAELQGTCTGVVACTQPRRIAAISVATRVAEEMDVQLGAHVGYHVRFDSRKCNATRVLYMTDGMLLREAFTDPDLTNYSVVVVDEAHERTIDTDVVLGLLKQLLTRRPSFRLVVMSATLDVAKIQSYFPCAPLVHVSGRMYNVDVFYMPEPVRDYVEATVSCVRQVHEREPAGDILCFLTGEAEIERAVAALHQALGSSSAGASKEQGAPVQGARADLTPLSTLAEDLAAPARPTEVVVLPLYGSLSLKDQQKVFATYPPNTRKVVVATNIAETSVTIDGIVYVVDCGYQKQSLYNSEARVDYLLPAVISKASAEQRKGRAGRTRPGKCFRLFTLVDFASFPDQAHPEILRTNIVNTVLLLLTLGIANPCEFPFIDPPSDQGMSDAFYQLLYFGAVNDGLELTDFGRRMAALPVDACLARMLLMAPKHGCGADTAVVAAMLEAGNAFSRPPAKLKEAREAHARFDDADGDHIVLFRVFHAYLKNQQNGKRFCHENYLRHQTLQQAVQVYNQLRWSMGQLKIPVRSTYIPERDYVDTVALRKAVLEGFFTQVARLTPAPSGSHRGGVDPTTRIYRTVRDALSVTLHRQSVLAAVQKSRALPAWIVFDRLEVQGDAGTFIRTASAVEVDWLLDVSHFYTDLSEIPDGDIAQVLRRAQEARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RP71</accession>
    <name>A0A088RP71_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_202320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698435.1">
        <property type="nucleotide sequence ID" value="XM_010700133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RP71"/>
    <dbReference type="GeneID" id="22574441"/>
    <dbReference type="KEGG" id="lpan:LPMP_202320"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200028600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_202320"/>
    <dbReference type="eggNOG" id="ENOG502SDAP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF131">
        <property type="entry name" value="BINDING PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="2">
        <location>
            <begin position="2"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="89" mass="10546" checksum="633A088A0CCF6A67" modified="2014-11-26" version="1">MSADELERYSKLVSNQRSKLSIPQKMEMYGLWRVATQGKCTLKQPSRTNLLQYRKWTAWKKYEHLTQQDARELFVEKAKAIIKKSPSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPC6</accession>
    <name>A0A088RPC6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_204630</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698664.1">
        <property type="nucleotide sequence ID" value="XM_010700362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPC6"/>
    <dbReference type="GeneID" id="22574675"/>
    <dbReference type="KEGG" id="lpan:LPMP_204630"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200053000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_204630"/>
    <dbReference type="eggNOG" id="ENOG502SMCV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1695362at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039121">
        <property type="entry name" value="NUDT19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318:SF0">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE NUDT19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318">
        <property type="entry name" value="TESTOSTERONE-REGULATED PROTEIN RP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN97957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="45298" checksum="A6496AB53C59995C" modified="2014-11-26" version="1">MSFELKAAVPRLASTILLLARRPQHAVSQQRRTTSNNASRENDLHVLMMKRHSKARFMPSFYVFPGGGIEGIDYATAKHYLAANYHVHLQDAEDKKMTQDFLESCAQPSAVEAEVEAWACRVGALRELAEETACVLRRDGHICTEAQWIKWQKSRDASAADRASTGSVSSLSATPLSVYDLPAVSSLRPVARWVSPRQFKHRYDTYFYAALVDSALVSAESHEEVPMPCSTQTSRGNEANPGAAVRHIPPQELPLLGQASEVSELLWVSPLEALRRHEDTSDSFSLAPPTYLILHALSLQPGFVSMAAAWEAEPPSPVDAVAKSLGELPYSSVLPCVEPISTTTEDGHRIIDFTLPARYFHETGWSMAEGEYLVPGANFAEYRHFIRVFVGRAGVPQVGGATVDRAYVILH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPM1</accession>
    <name>A0A088RPM1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatidylinositol-4-phosphate-5-kinase-likep ro tein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_202790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97775.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698482.1">
        <property type="nucleotide sequence ID" value="XM_010700180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPM1"/>
    <dbReference type="GeneID" id="22574489"/>
    <dbReference type="KEGG" id="lpan:LPMP_202790"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000010000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_202790"/>
    <dbReference type="eggNOG" id="KOG0229">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20783at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00139">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97775.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="547" mass="61318" checksum="37F9F7885290DBF1" modified="2026-01-28" version="2">MPLNRELLASVRLEAVSESDWMEEGYDKANDSRSAGADGSVQGASPNTDGNDDQNAATKKVIHCLKIALERVITSISLPEKRRPLNPQKDFSIASTINFSASRRAETIACCGPNAASVKKARGQQMRDSRTPVIGGPNRQGHRLRSEASHVLPMDEAMLRSEDDIDRNYGGLTTSGGIFESTVTRENRLHRSLARTQTLVDFSTDDEDDEDEEAIPPASFTFTDFSPMCYRHIREFFHVDSTAYCDVLCNSRWHSIPTPGKSAAQLFFCGRDWVIKTMTEQESNFLCKILHRYYYHVRDNPFTLLPHFVGHYRLRIGRNTHIFIIMQNVFATTNTIHEKFDLKGSTIGRFASDAEKRRTTFTQKDLDINSPMHLGMERRLLLIDQVKKDCEFLKRSMIMDYSFLVGIHVLPMTGNTLSSVNPGGLLGMLTRSVTDATLRTITTLGYTTAGDRLESPGADVAEFARSGVFLDGRCFTADQGGMLSNKVPGLRQEIYYIGIIDILQEYTARKALENAVLGSIYDRKRISCVQPNDYAARFIAFISSIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPY8</accession>
    <name>A0A088RPY8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_204160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698617.1">
        <property type="nucleotide sequence ID" value="XM_010700315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPY8"/>
    <dbReference type="GeneID" id="22574627"/>
    <dbReference type="KEGG" id="lpan:LPMP_204160"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200047700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_204160"/>
    <dbReference type="eggNOG" id="ENOG502SAAH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268801at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="119" mass="13614" checksum="17B68037E206C316" modified="2014-11-26" version="1">MKLNFLGYSNEDQSLASVWGRLISLSCIVTGVFYVLFGLFACRRLILRDIRWLLMAILYFSIGVCHAFLTLALLCFAIACVLHTFEKPMQIEEMFVYSGIMAIITMYFACGRKTILYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQ76</accession>
    <name>A0A088RQ76_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoside triphosphate hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_190620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698057.1">
        <property type="nucleotide sequence ID" value="XM_010699755.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22574116"/>
    <dbReference type="KEGG" id="lpan:LPMP_190620"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190015000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_190620"/>
    <dbReference type="eggNOG" id="KOG0922">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="447637at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35388">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35388:SF2">
        <property type="entry name" value="SURP MOTIF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00648">
        <property type="entry name" value="SWAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
        <property type="entry name" value="SURP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SURP motif" evidence="2">
        <location>
            <begin position="1337"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1295"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1819"/>
            <end position="1858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1911"/>
            <end position="1935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1295"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1819"/>
            <end position="1835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1846"/>
            <end position="1858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1923"/>
            <end position="1935"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1935" mass="204179" checksum="AFC07AC830E6DB51" modified="2014-11-26" version="1">MSCSLNTFPTTRHACPIAPVSALRAAVERLQQPDATAAGCVDTRRPNYLLDVPISAIDVDRWEKRWQEAMSVASSPSPALGVGAKGPLHFQHASTAYAALMASDEASAPTRALSMRHLAPLRPFVFATVKTLPMTQLLKMRRQWLPHRQRFAVHQKRMGLLDAVLNHALVALVGPAGSGRTLQVPIVLSETEVFKRRRLIVVSANAAAARLTTLRLREERGEDVQNSRTVAAAVPNHNETTESTSVVVTTAEVMLRQLLCDPCLEGVGCVVFDDAHLRNESTELCLSLLRDLLAVQQQWEHQRGAAAGSASNGAAADPDADTAQGLDAARRRKLHVVLNCPDEACATTLLSFLAPSRCTATTFMLQAAPSLVTATTTLYLEEAVQWLLKSEKEGSCLISDSATMEAALMSYAENVDAVARIMAAGDADFAHPAAFRRYWLPLIQQCVDEFDKADRHTAGATAAQGLSPLSAILIVAPNNHYVRVIANALREVQQTLAEGDAAASRVCTTLADDSPLSAFMTVAQRTAVRDAHQRWVIVATGELSQSVLPSGLDVGLVVDCARNGYTAVDTTTMADTVVIEYSTITQLRHRRKLAKMTAVVSSAAGGDGSTAASPVVIQLIPKSVLHGAHHRRLSADPTQHIIFRLPFSRYVHVYEVLQAREEAAVSQRALFSLSATGGGNMSGVGSGPSIASKVSALLASQLIGVPSATATRYDAVRRIMTSVELYLRAAGHLAVDHTAGSPVMGQLVLQPIAVLCLCLPVPLQVGRLLIAGSLLRPSLAAVTAVGALWCCSDLLSLQGAGAVRAADVSDAAREAVEEQAALLTEARLFFSRDSLSDVVSAFNVYQMWCSAKGKPDVERDFLEECGVAGEVLQAVFDTQVQLCILMRTYGLLLHPGDEGESSRAGAVESEAERTLRVCVESIQQSTSDSAAQVSSALANAMAALPVEVATNRSLHACVTAALYPSCVVPTGEHGVGLVYDGVSTSSIGGAAGVAESSGSGPQAAGTGRRVATFSTNCVLADAAQCANAAGRPFLFLAKSIADAATREAAGIGTSSTVAATVVEQVDPLHEAAAVVFCGNIYERPRKAPTRCRGWASVLTSRWRETRRARALPPVSQLPLTCISVQSYDTVHCNHVICSMDQCLSFTLRATTAKWLQLLRTHVGVHLAALTRGVSTPKDAGSPTEASSALATEVAQAWGWWERRHQQGRDWLREERVVAAHQQQQKDDATAVGHDEQPQRAMAAAAKVAALRQRLFAYYEWQIRPGAPAAVVVPSNAERQAFAKSAAAAAAAAKGNNEIDNGDAGNAAGDDDDIAAEGADGVQASYSGKVPPADIDHIFRLCVKSVATKGTREAEAQLLRDNPDMFAFLNPEDEFHEYYLYLLRQAAPNMEVLGDNLEELITFLECLETELREELGLPDPNAATQQNAEGILSGQDNGEGTAYGTGAADMWGSGGSGDANGQWNSSPFGGGYAVHDVLVGEGDVDGYGDGDNDGLQLESAAINLKKSAGPTLAEKIEEAKRAQANAAPTAVKSADVVPPIMIASPAAPVQMTVPAVLSSASSNTPFVSTNAGETLADKLRAMQMAAMGGSPNCASDLGQLQFSAQSNSDPTSVQQESAAPCGVLPPPPTAADLLAVINGGDTSDTAPPQSSLGISFQQAPPTAEELMALLGPALPAAAATDPFPAGSSLGSILGSASPPSATMAAMMMGIPTTPLHRPPPAIPAKAIEERPPSVLVYPVPDTRKHGNVRLLLAKSLSESLNMRVGPTTVVGHVARIDVPNRNVEARALALKKFVCGDTKITVHLFKNDRIIDDPELQERERRKRREEMRQQEAERHVRQRRRTEAPASGDASGRANASRRAGGADAALIGSAAFDPTCPDALNEPSVYNAAAPVPTMVLRAAKAAQMKIGVLSSSEDDDGDNVSSSANSSSSSSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RR40</accession>
    <name>A0A088RR40_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_221540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699155.1">
        <property type="nucleotide sequence ID" value="XM_010700853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RR40"/>
    <dbReference type="GeneID" id="22575200"/>
    <dbReference type="KEGG" id="lpan:LPMP_221540"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220019000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_221540"/>
    <dbReference type="eggNOG" id="ENOG502S6AE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="238138at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="103" mass="12894" checksum="12BC2629EF2D6BDF" modified="2014-11-26" version="1">MPTEHVPAVTVEEASDFWANPVDHFRPNLKFLSVYVEHQYVVDKWLHVKEKWLKPWYLPWWTPMYQVMTWYSQRNRNLMLVENNLNYRPYRYRRNDEDSKNPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRR1</accession>
    <name>A0A088RRR1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD-dependent protein deacylase</fullName>
            <ecNumber evidence="5">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Regulatory protein SIR2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_231350</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N(6)-acetyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-acetyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:43636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="ChEBI" id="CHEBI:83767"/>
            <dbReference type="EC" id="2.3.1.286"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sirtuin family. Class II subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699292.1">
        <property type="nucleotide sequence ID" value="XM_010700990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRR1"/>
    <dbReference type="SMR" id="A0A088RRR1"/>
    <dbReference type="GeneID" id="22575340"/>
    <dbReference type="KEGG" id="lpan:LPMP_231350"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230021100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_231350"/>
    <dbReference type="eggNOG" id="KOG2683">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="424302at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01967">
        <property type="entry name" value="Sirtuin_ClassII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026587">
        <property type="entry name" value="Sirtuin_class_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF10">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 5 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5 6">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="108"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="248"/>
            <end position="250"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="274"/>
            <end position="276"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN98585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="320" mass="35284" checksum="98B9C4AB3F2630DA" modified="2014-11-26" version="1">MRPAWALASFMEHCNARKPGRSCVVLTGAGCSTESGIPDYRGPNGRYHRADFVPLTFQKFMGDDNEKRRYWARSMLGYSTMSGASCNATHMVLQAFTKSGAVSYILTQNVDGLHHLAMYGGVGDAEEKHYYKYTTSDAPLTEVHGNIHNVICTSCGFLMPRARLQRELREKNSGLYEEYGEDLSRVRPDGDYSAPTEVVNSMQLVMCPQCDGFFKPHVVLFGENVPKPIVESTMSVIDDKASCLLCLGTSLQVYSAYRYVLEAKQLGIPVAIVNSGTTRGDPIADLRLNVESVGSVLAETAHEILGVPAPMFFSRKTIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RS13</accession>
    <name>A0A088RS13_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Calpain-like cysteine peptidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_205380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN98029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698736.1">
        <property type="nucleotide sequence ID" value="XM_010700434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RS13"/>
    <dbReference type="GeneID" id="22574750"/>
    <dbReference type="KEGG" id="lpan:LPMP_205380"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200060700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_205380"/>
    <dbReference type="eggNOG" id="KOG0045">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="424753at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015232">
        <property type="entry name" value="DUF1935"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036310">
        <property type="entry name" value="Smp-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF423">
        <property type="entry name" value="LEUCINE-RICH REPEAT PROTEIN (LRRP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09149">
        <property type="entry name" value="DUF1935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101601">
        <property type="entry name" value="Smp-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="3">
        <location>
            <begin position="188"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN98029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="743" mass="82955" checksum="F0451E056A7E3C0F" modified="2014-11-26" version="1">MFDEFREDSVEPLPVDASKNPSTPWVNWGPSIAGEATPCFKGGFLYRIIDSKKKLWALYNDTFVYEMHATFIFGTASNMQPITTASSSVSENGGEVDGKNRVVASVEGNGLTISMVVYPMETIEFARGDKSKYSCHFDGKALSKEYLQLEMALANAELEENKEKLARYTCIATDPENVLALCKTHQLAFIDPSFPPGQHSLDGDRGLIAPSAWRRPEAYLPLALRRQIRLFRHQVAPSAAQRGELGNSWVMSAMAALAEYPDHIRDMFRHPVNPKETQRDEAAGAYRVWLNKDGLWQSVLIDSYLPVIGKQQRYARSANGPCEMWVSYLEKAYAKRCHGYSNIAGGDPLFAIRDFTGFPTSRLDVRFRECVTDPVKSDMFFLRMVQDYENGYVVLLSTPGNSDPRSAHSAYKENGIFVGYAYVVLDARVIESPISRRKKVQPLRLLRLRNSWEAATKWSGKWSAESPMWQEHPEACEAFPQHNGDGTFIMEWSEVLDIFVGFGVVFNHFGYVDYRIPFEFHGSVPDLCLEIHVTELTTLTLILSQPDNKGTMRESEDYNPIMISIAGATTTTTSPVFQDSSMRSSGASSHTMMVGSAQLVAQHYSILVNSSADAETPSKSFTFLQGRDISAIYTFIPEQSPYLVVPRLLVQQPSRINEVSASSTAALSASNRAVTRPCVLGVLSQLALTLYGQAHVRLRKLPAKSPVFDNYLSFTNNSVEVEKTFYVKCSGASVVERRASELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RS28</accession>
    <name>A0A088RS28_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_241300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699470.1">
        <property type="nucleotide sequence ID" value="XM_010701168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RS28"/>
    <dbReference type="GeneID" id="22575539"/>
    <dbReference type="KEGG" id="lpan:LPMP_241300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240021800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_241300"/>
    <dbReference type="eggNOG" id="ENOG502S7UN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="247137at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="91" mass="10349" checksum="8DB1D5CC1F0385A0" modified="2014-11-26" version="1">MFYGVRMCRAAVANTAPGILHRAASLQSETPCARLADKIVRGPLKSVYYTHPSYVMSRDKMLHTIWVDLGIFHTCAYVLFPFFFIANFFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RT71</accession>
    <name>A0A088RT71_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCR4-NOT transcription complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_230020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CNOT11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699161.1">
        <property type="nucleotide sequence ID" value="XM_010700859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RT71"/>
    <dbReference type="GeneID" id="22575206"/>
    <dbReference type="KEGG" id="lpan:LPMP_230020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230005000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_230020"/>
    <dbReference type="eggNOG" id="ENOG502QTS3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10265389at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019312">
        <property type="entry name" value="CNOT11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15975">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15975:SF0">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN98454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="383" mass="42900" checksum="B84677FD5A3A7AF2" modified="2014-11-26" version="1">MCKEFVASTEGTALLAALYIVDYMRKQDNVAAKSTFYDVLIELEHAIRRDMFIVEQIKYTTKESKEGKKSIEATRAEAFRIHCAAKVFAFQLLGDVVADDEKVVSYASKKQESIDEALNAWEKASIKIKEPMADIEHCWVAKQEKQQCGSLYETAAVFDEQPNKTFALLLPSITAKLPMLPMQEGELQYVLPGKSGMLLLDSAPPSEGWMISKRLLVQARKSKLSKDDEQALLGLLNESLVSRLGVSPQQLSELATHNPEVCASVLLKLPSGSAGAFIQFLLKGNIPEENMQTILLRASSVLQQVNVRTFISTMIHKLRERGELSTGAESVKNFALSLHQLVMKAAKENREIFIADAFRPDLEQLFQSSSNPEVKNRWEDMKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTC3</accession>
    <name>A0A088RTC3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Axoneme dynein-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_261100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699930.1">
        <property type="nucleotide sequence ID" value="XM_010701628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTC3"/>
    <dbReference type="GeneID" id="22576013"/>
    <dbReference type="KEGG" id="lpan:LPMP_261100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260015900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_261100"/>
    <dbReference type="eggNOG" id="KOG4001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277800at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019347">
        <property type="entry name" value="Axonemal_dynein_light_chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13183:SF2">
        <property type="entry name" value="ARM LIGHT CHAIN, AXONEMAL, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13183">
        <property type="entry name" value="AXONEMAL INNER ARM DYNEIN LIGHT CHAIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10211">
        <property type="entry name" value="Ax_dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="240"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="264"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="473" mass="50302" checksum="B4465CB8E041547F" modified="2014-11-26" version="1">MAVPEGRSIYEVLGTVLYCTVPVIIDNADDPNAEQQQQQQKQWGDVDIPLDYAAALALREIDEAAMAARYTATKARGAASATVGGAASRDGAMVAERVPFAAAAAGASAAVPSTVPVPPQRSGTPPFMSARYGTLGGGGRQFPAAKTTQRVCSGGSASRNAFGASLRSGAEVGGTQRDAGEAVDIATQNAYLVKAHIRAAVAAKSGSGTAAGPAALRSTRGSSGNGALTVAQAMEILFPIEPEGHGGGSRDDSAKDGEKETSYGTLTSPLSASPSGALGAATTAAATSAASTPVMWRRADVSHLSRLDVVLLYKHLQRRCTCESARPRGFVCPNRERIYNDGLRELIRQVTLLCPERGLLLDELARSMRESIETYDVLLDSANQYAVRKSTERDLHQYLFAEKAALETEVRRREYRVSEWRAKYAGLQKRFQEQQAADSKLHAEEIAYAKRANQQLVSEIKRLASEAEKAKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTI7</accession>
    <name>A0A088RTI7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="5">6.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_231190</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = (6R)-5,10-methenyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="5"/>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699276.1">
        <property type="nucleotide sequence ID" value="XM_010700974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTI7"/>
    <dbReference type="GeneID" id="22575324"/>
    <dbReference type="KEGG" id="lpan:LPMP_231190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230019000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_231190"/>
    <dbReference type="eggNOG" id="ENOG502S6GR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2015992at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030272">
        <property type="term" value="F:5-formyltetrahydrofolate cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407">
        <property type="entry name" value="ATPASE INHIBITOR/5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00036539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN98569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="449" mass="48046" checksum="2BD692C5B856C6EB" modified="2014-11-26" version="1">MQSLPTAHVKKVLRKEQLLRLRRWAKSDPAQVVAASQQICDHVYGYILARYRPGATAAARETSSSLPLGAAAGPDAPLPAPLSPPPLLVLAYLPLYFEVDLVPLMQRLWSIAHEQNIHILTPVVLSEAMAALPTAGAVPALSVKPTAQPGSSALSNPLPVALPAPHTLKSAMVFVEVLDERDLATGFAPQGGYGIREFNISLLEPWLLGPLHTSTFGTLAPLHSPSTLGGVRGDDEDGHVVRSCCHGRQRHMILCDAYARLFPESHAAGYRPSGLLEYGDFSEGSSTHLSPRVHGEDTHSLCSLDKASMLVLTPGVLFDVSTGARLGKGGGFYDRFFSYHGSAHHNRFPADSLPPRIGAQEEEGAAVGTEAVVDALPLSPSGVSFPKWEVMGLAFDDQVLHPSAASTSVPVSTVPDSSMPSRIPVDTHDQLMHFVVSPSCGIEQVWQYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTW4</accession>
    <name>A0A088RTW4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Branched-chain amino acid aminotransferase, putative</fullName>
            <ecNumber evidence="9">2.6.1.42</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_272030</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="9"/>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700289.1">
        <property type="nucleotide sequence ID" value="XM_010701987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTW4"/>
    <dbReference type="GeneID" id="22576381"/>
    <dbReference type="KEGG" id="lpan:LPMP_272030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270028600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_272030"/>
    <dbReference type="eggNOG" id="KOG0975">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270718at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004084">
        <property type="term" value="F:branched-chain-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009082">
        <property type="term" value="P:branched-chain amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000004">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF44">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN99582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="401" mass="44084" checksum="8C56886F1FE8869E" modified="2014-11-26" version="1">MFLSRLWRQGSAACDSKAPVASFTAAALTKKLVTNPPPLPPMKGVAFGTVFSPHMVLIDYEDGKWGAPQIVPFANFSFPPQTSCLHYATQCFDGMKVYADIGDITKVSKGEKLGKQNLRLFRPDRHVARLNDSMHALCFPGFDEAEMLKIITEFVRTEKNYVPKEHGYSLYLRPAAIGTAACLGATPSRSVRLFVIASPVGPYYPLPEGHSDGVIIKPVSLLVEETRKRAWPGGTGGRKVGANYAGPLLVQDEAKARGYNQVLWLGAQDEVQEAGFMNFCTMWKTKEGKTELVTAPLDGTILPGVTRDSILELARSWGEFEVSVRPYYVSELIEALQEGRVIECFGCGTALVVSPVNMLAYRGKEYSVPFPAQSYASRFLQAIIDIQYGKTPSPWSVKIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUI3</accession>
    <name>A0A088RUI3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_281740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700514.1">
        <property type="nucleotide sequence ID" value="XM_010702212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUI3"/>
    <dbReference type="GeneID" id="22576619"/>
    <dbReference type="KEGG" id="lpan:LPMP_281740"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_281740"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="74" mass="8205" checksum="CE6CB34137010455" modified="2014-11-26" version="1">MMLVERAQLLTFPSPYSFPVFSTFCSSLPAAAAAAASLPLPPTLWRFFRSLSFALLARRCPLSNFFLFPQCVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUL0</accession>
    <name>A0A088RUL0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_282090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700549.1">
        <property type="nucleotide sequence ID" value="XM_010702247.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22576654"/>
    <dbReference type="KEGG" id="lpan:LPMP_282090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000037100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_282090"/>
    <dbReference type="eggNOG" id="ENOG502SKS8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="248587at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031464">
        <property type="term" value="C:Cul4A-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019902">
        <property type="term" value="F:phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022162">
        <property type="entry name" value="TRPC4AP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31743:SF1">
        <property type="entry name" value="SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 4-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31743">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CHANNEL 4-ASSOCIATED PROTEIN TCPC4AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1421" mass="158130" checksum="D312B9A20135B3D1" modified="2014-11-26" version="1">MSLRSLVTSGQEPLPPRRLPAYAYYTAPHTRTLAPDTSAQELVSLIWKLWLDGQYSELGKRLGNAGDILERKDNVRFACEFLASGGLDIYCLILCDPFNPLRFLPERTTRNMTSLERGRWKRTLGHVIGIYAEVMLQLTDLVANQNDLGWVIYDRYPGVFYRLIELLEDNSLWTTATGLLEHILACVGPVLEISKNSSLIRVLRHASPTALAAFCRFLALLILPGLAQGQNPIVARRLHYPETVAVLRQVQRVVDSNVLWLIGEEGLVSTLISLCELRPNGLRVQQGGRSMMVLPPETALLRGDGQRAVNATRAGGRTSMMPLGSEDIEWEDEEEAGRLADNEVHEGSGASGGSGGAADFLVNGSSLPTLFAGIEHLLGIRWSQSQAPRAPGPFIDATLPSSQQLQQLSASPAWTNLSGTFPPRADEPAALSEYLERMRTNARSDTASAAFGVNRSPLGVALPPPPLSTSPPRGGIRVEVGGDGGGVSAQVVAELERAGLPLDGAEQLAYLNRVTSNQFQAEDPSWLVQWLLDGDILEEDDMTQSFKTSMDIHWWVGSADTRQRWRLRDPSLIPERDDNRHALLCLAVRRTVAPGPRPPTLEEFNAANERLLSMLIEPLPRVDDLALLSPMDMQRILESQSEVLYLLNMFLSTFYFSDSWRALRDCRWVPRSVPILEAAFGLDPSLPALVDVPPHVHLPDKLRALPRYLPPCAPIDQEEPATLADGSPRYPATWRLVPLLKLLGDLAVVYLRDPNQMCEEEPENHQHGPDTMRKMELLRVLYEYWNAQDRREQEMVVEDAEVVASAWRNAAAIARVVHIDQEDSCVRISLYQTLDSYLRTFLFREAYRDAPDSPQTRLGQALLTSILERIYNGTQIPGLSGSMTPGRLLSNMLQFLGELLRYHAGNLRTLCAYVVGDRDMSHLNEAVRSSNRQNSVILSAAHAEDEEILKRLPLEREEHEPFGSVLLRRLFTFGADTHHLLRSLLLSLTPGLRSTANYLSKPVMDSAGDVRLPPILPGVGRTSDIISGDAVRISYVIRVSRQYAREISLAPPHGLRREELLRELVCVLARTPHRQAPEHRPFPGLMCGENDLALLRSQWPLPTVGPPPHLRAPLFGCHPSDSAKTPPTPSTEPLLSATQEILNTLRSPNASATHLHHSAATTEDAVRLEELAPLARLLLGEPHKLIFSALCGLNIESMEDNSRLSVVTTVLLVFLRVASIGSSRESAAAAEASIRDVLAKMQSFARHGYDVWLGEKRATRAKEREARSRQASMSFSGDQGVCMCYWRNAAEAAEVEGRYSKRSETASAITDSLEGPRRDDRAAAKGRLVPDELPRRCPSFMAYGSCDPPHEGSVYQRDFGGCFYRNFFRLLCLWVGYYASCQRYVETVYFSTEVAFGEYKTMALFLMRILPDFFMPYFSQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUY5</accession>
    <name>A0A088RUY5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cation transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_282050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700545.1">
        <property type="nucleotide sequence ID" value="XM_010702243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUY5"/>
    <dbReference type="GeneID" id="22576650"/>
    <dbReference type="KEGG" id="lpan:LPMP_282050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280027200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_282050"/>
    <dbReference type="eggNOG" id="ENOG502TKPF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="29879at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF51">
        <property type="entry name" value="MANGANESE RESISTANCE PROTEIN MNR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="603"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="637"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN99838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="673" mass="72558" checksum="8C3248C3296D8856" modified="2014-11-26" version="1">MSASHQRSGGTSVSEVEMTQRNSATMKSQSSPLLRGGDSTATTTMSAVGGGSAGKNTDGIRIRVRYLVEGVTDAAWRLVPNVATLKQMVCEQDQYFALPPSPTGDGDHFAKLPLQLPARTPATTNASPTVPSEPTADKTHGPFAFPAIRLSPTSTPNSDACPAWVSIKAATEEELAEVLESLPVHVLTRRRIISVLCADEDAEGLMELGNSESSSDEEDTESSSDGGREKDGRARRYTTVRDNFFEYFPAHGYAVLCLQAVGLQRMESTRCGAIQHDGMNRRGAQLPCTPVVALAFESALFTFSAGHFGGEGDVELIVANHAWVSESTRGTGGTGVWGLHSAASHLSTVGGLKGAESGKTETGDTPSVEWERQCDTSLPLDDAGSLFKDQVNGATPDVPRGSAAGRGVERAPLTYPAVAAVGAAPPPLSARQMRETQQAMAPFGSPSDPTSPNYRVNIAISVVCSSLVSAIIAYLQKSVRVLLIEADQLDELVLQILPSRVDQDDMLVRIKSLRHLIALFHIDSLQKERVLKELLLPAMRRTPLSRSTPAVERYQRLLSSIRSTILKLRKSRDIVNRASMTLISGVSARLLSHCHFMDYLNHVQTQITVIVMPVTIIPNLFAMNVRVPFTDAETTTPFFCIVIITLMLLLAGVSPILYKFLMYKTPGALATME</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RV15</accession>
    <name>A0A088RV15_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoprotein 96-92, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_282350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700575.1">
        <property type="nucleotide sequence ID" value="XM_010702273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RV15"/>
    <dbReference type="GeneID" id="22576680"/>
    <dbReference type="KEGG" id="lpan:LPMP_282350"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280029700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_282350"/>
    <dbReference type="eggNOG" id="ENOG502RSJB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268063at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="403" mass="48331" checksum="B39537603701B304" modified="2014-11-26" version="1">MSSAGSDTAVQHVDPEAEVSGTPLNNTSCEEAAAADSFHINGADNDKPLSEIPSTKKRLLRKENKGGSSAEVARRLKQEEKKLAEKIAKAREAEAQAAKEKANRVRQAEAERRKKRDEKDARAQKGVEEERKLKEEQKRQREEEEKQRAEMVRKQREESQRKREEIQRQREEEMKRRKAEAEAEKQRLKELQEEHEKKLEEARQHRIAEEKEAQKRTEKKAEDDFSATRRQRKEEEEQRLRQREEEEKQRAEMVRKQREESQRKREELKQKEAKEAEEIKRQRKEVQAELQKKREKEQQELRKKVSERRMKGKTDSKKEQILQQKKMAAAAERERLEEQLRKQKEAEEREIAEKHRRVMEQLEKNYEIVNEEEYERERREREERAREERGGMDKVTEEVLVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVB4</accession>
    <name>A0A088RVB4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_282320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700572.1">
        <property type="nucleotide sequence ID" value="XM_010702270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVB4"/>
    <dbReference type="GeneID" id="22576677"/>
    <dbReference type="KEGG" id="lpan:LPMP_282320"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280029500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_282320"/>
    <dbReference type="eggNOG" id="ENOG502S9GB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264404at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="471"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="592"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="595"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="612"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="632"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="727"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="894" mass="96573" checksum="9A40BAC44E1F0011" modified="2014-11-26" version="1">MEQKKPIAATARTKTPSVNSGVSVLQSLQRENDTLRSELLRSKQHKTQLQRQLNDLRIVTEQIVREVTMSSKEQVRALEERCRLLADRLVGSKREEQVTETARVGFLLRSQIEERQFLRRGLEAMQEVLVGVGDSAASGFRNGQLSVSASTRPADEGRDGEVHTGDLYRLMMTVSDALHAHTASAKLEKARTRLTLEQAASLLDELRDAVEDATRAAFDAAVQTSVVCDAGTTLAAGGDAFQLSSMLMAPRGTPAATAQNASGFADITSFLHRQGAGASPFAYSAMAPSPSAQLSLELEWVCDVLKACMKGATEVRVLLGAAAEGLKAPPLQQRRRVAGDRSSATEQVPPLELTASPEMNALLCSFLEDLSTIKERAARQQEDMARQLAHEVERHFQSTQQYEERVKLLEAECARLLFYMEKQATQSPRVDATTPTPARQHAAVSAMLMPSLVPVQDTHITPERYIATRDVAKLSERRPARPPRKPSAETSRVLLADQRTPPQVSRSARPMEAQNAALSTSADHAIKVDKPAHANRDTSPHYFLQEFSLDRPYSASEQSRATVPIAPSPTASAIWSAYRDRKARLQHLTSEALRSPPGLHSPLLSPAPPAVHPKTLTTTTSSSTAFAHSLSPQRRSTTVSTPPRQQGTATFRTGTPTPVLSSVFSTPKRSSVHPNNAADGSVSPHNLTRAAAAPLSSAEPPPAITTAAGPRDPTPPLSGTPVTTSRQGHKTSRHHTHLPHQLYDEAAADFFSFHSTSFGAAPSTLSSMQRLRLGSSQMSDFGGTAEMRTQSPWRLVQPTSNSNRASPGEFTVLRTGRQLHTPPGPVSGVLLGHASRGGGAVDTFGQAETPDTPPIWRRIKEEASFQPQHSPSPIAGGDASSLFGTPCEVPWANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWC5</accession>
    <name>A0A088RWC5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_302450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701268.1">
        <property type="nucleotide sequence ID" value="XM_010702966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWC5"/>
    <dbReference type="GeneID" id="22577298"/>
    <dbReference type="KEGG" id="lpan:LPMP_302450"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300029100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_302450"/>
    <dbReference type="eggNOG" id="ENOG502RXIK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275643at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="22533" checksum="14DE1F06A058A2E1" modified="2014-11-26" version="1">MPYIAYPSAVSGSTSAEASCDAREDAFGEYAAYRRVIRTILCGVFFATPLCAAIPMSPLLKLSQTQENKKSIIPRMMSDFFYVNFFASAAAYWVLVEPFIPNPRAKEGFVPYLGPVTAEIPAVSCLLLSHLFYPGLWAIVNEPTWKLRRQEFVRLNTKCFLAFGPIHVPAAVGLGAAVGVTLYPFKYMKLRTQHRDERPQSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWM3</accession>
    <name>A0A088RWM3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosomal passenger protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CPC1</name>
        <name evidence="2" type="ORF">LPMP_303460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701368.1">
        <property type="nucleotide sequence ID" value="XM_010703066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWM3"/>
    <dbReference type="GeneID" id="22577399"/>
    <dbReference type="KEGG" id="lpan:LPMP_303460"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300039500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_303460"/>
    <dbReference type="eggNOG" id="ENOG502RYX1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269618at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="245" mass="26698" checksum="D2F8EE132BF1CD71" modified="2014-11-26" version="1">MEAMVWSPDVVEDLLFRQFIKDEDISRQLPPAPQVSSENFLEKYDQATKILFSYVRNGPVSALASQNVNTAAIGKHGGGTPLKGFVGRTPATKPAPPESSRSFARTATPTPAPTSRAPSVQKANTSPPPPTKKRQRVEWPTDVPTNQMLKSNSRSKVAHLTAKRVAAQQGVDPDLIFTQNFGDLPLSVIFAPYPKALKSVSAVRNASGDWRTDAFTVEEEAAYKNDLGYVHCGPSQCAHDKWLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWN4</accession>
    <name>A0A088RWN4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATP synthase, epsilon chain, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_303560</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701378.1">
        <property type="nucleotide sequence ID" value="XM_010703076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWN4"/>
    <dbReference type="GeneID" id="22577409"/>
    <dbReference type="KEGG" id="lpan:LPMP_303560"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300040500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_303560"/>
    <dbReference type="eggNOG" id="KOG1758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270171at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.15.10:FF:000014">
        <property type="entry name" value="ATP synthase, epsilon chain, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="entry name" value="F0F1 ATP synthase delta/epsilon subunit, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="ATP SYNTHASE DELTA/EPSILON CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822:SF7">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT DELTA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="Epsilon subunit of F1F0-ATP synthase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP synthase F1 complex delta/epsilon subunit N-terminal" evidence="10">
        <location>
            <begin position="49"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIO00578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="181" mass="20146" checksum="53B5956C0A7F421A" modified="2014-11-26" version="1">MFRFCGRRLVGRTLPLLADHHELPEAFEFMEHKVIDKDIHAAYENMDTLRLTITRQDEFLFKEAPVKCVTVMGVNGENGVYPSHAYKITQLAPAPLTVEMTDGTVEKFFTSGGFAHINNEGSCDINCVECIPLSELDVDAAEKALAQQQSALSSAHDEKAKAVVEIRINVLESVLQSLKHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWQ9</accession>
    <name>A0A088RWQ9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AAA family ATPase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_302460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00469.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701269.1">
        <property type="nucleotide sequence ID" value="XM_010702967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWQ9"/>
    <dbReference type="GeneID" id="22577299"/>
    <dbReference type="KEGG" id="lpan:LPMP_302460"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300029200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_302460"/>
    <dbReference type="eggNOG" id="KOG0730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000567">
        <property type="entry name" value="ATPase, AAA family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF27">
        <property type="entry name" value="ATPASE FAMILY GENE 2 PROTEIN HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO00469.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="944" mass="100002" checksum="E1BDD7F7E54AB34B" modified="2026-01-28" version="2">MPAKKRLVPPLRPNADGSGFVQAFRGRGPAHNRSSGAHRPIASTSSSGSSTSSSASSCSLSAAEPATLSHSSVGRYKARGERRRSSAATLLLPQRKACISTSAEDHKGHLKTTDTKYHTAVTQGLSPLASAPASVSAVDSLLSASPGTGSPTKKKEQHTAWISGAASRSTRRSDVGAPAGKARGVAPAMLTIGVDGALGPSECLLATSVMHRLGLQSGHIVRLSTSYGDVYAGVRPKRGSAVASDKIFVNEDAAAVLVDVSPVVLCPVLLPQNGVPTLRSVTLTMVVPENARDANTCDAVVPSIASTMEWQALFRRTLHHKIAYLHLRTTQRVLTHRIALEVVNLSVASQGEESSTSAAESDAAWGIVTDATEVRFYNHNAAAGVSIGGQQCASTGLGRSAVETCQEGVPFCSGCLCTLVVGGTGVGKSRWLSLHAPTASHTEQQRHMDASTSPATAAGSRRYTEWVHVDQLPQGEGSEVTTATALHEVFERARQSAPATVAIDDLHLICGREASSAGSRWAMSLIAHALAAELLDLQSRRLDVGVIASAPTLASLDACLTVATLFGGSVVTLEMPSGPQERLACLRMCLLELRLNDSAAGPGLSEACLLEVAERAHGFTQRDLHRLVETAVMQAFQTRQSIVPTDADLRAASAIVHPSSLKHFEVSVPTVTWADIGGSAEAKQTLCDVVDWCLGKQSWLFTEFNLTPPKGVLLYGPPGCSKTMLAKALANESRMNFISVKGPEVFSKWVGDSEKAVRDIFERARAASPCVVFIDELDGMCGHRGRGGVSDRVISQFLTELDGLPAAFGEKKRALVFVAATNRPDSIDGAVLRPGRIDRRVYVGLPTLPERCAITDIQFKHLPVAADLTAHYVAERTEGYTGAEVVAVVKEAAFHAITVNASACHVTLADIDAALQKVRPRISAKDVEWYKHWPNNRKTTTACV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWZ3</accession>
    <name>A0A088RWZ3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">4-hydroxybenzoate polyprenyltransferase, mitochondrial</fullName>
            <shortName evidence="9">4-HB polyprenyltransferase</shortName>
            <ecNumber evidence="9">2.5.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Para-hydroxybenzoate--polyprenyltransferase</fullName>
            <shortName evidence="9">PHB:PPT</shortName>
            <shortName evidence="9">PHB:polyprenyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_281410</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>an all-trans-polyprenyl diphosphate + 4-hydroxybenzoate = a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:44504"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:9564"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58914"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="2.5.1.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
            <orientation evidence="9">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.39" evidence="9"/>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700481.1">
        <property type="nucleotide sequence ID" value="XM_010702179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWZ3"/>
    <dbReference type="GeneID" id="22576586"/>
    <dbReference type="KEGG" id="lpan:LPMP_281410"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280020100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_281410"/>
    <dbReference type="eggNOG" id="KOG1381">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18170at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008412">
        <property type="term" value="F:4-hydroxybenzoate polyprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000008">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1780:FF:000001">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01635">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006370">
        <property type="entry name" value="HB_polyprenyltransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF28">
        <property type="entry name" value="4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN99774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="489" mass="54688" checksum="E44020290FB58351" modified="2014-11-26" version="1">MFRQTPLYPKVTRSWTKSSISAATAHFPDAVLADPAASRSGTISAKEERSWRLDDNTVKVEKLPKHFQFVVRKLQLYGNLVRFDRPVGWQLLLIPCYWGSSLAVTRALVWEGADPVVLCAPFIPFHLAVQFLVGAYLMRSVGCIVNDMWDRKFDRMVERTAQRPLACGAVSMTEASAILLSHLIAASVIALNLSPAALLASVAVTPLWILYPLMKRITHAPQLFLGLCFNWGIFVGYAAVLGRVDMAVCVPIYCAAVIWTILYDTIYAYQDRRDDLKCGIKSTAIWIGDRKYILSAMVAPIGGGMLISGFLASQSLPYYIGIILCMYRLHSIVDDVNIYDSWSCAQGFTRNVRLGMYVFLAMCLGNLCWAFASEHEAELDRNTDSAPKSSILSRFLFLDQETREASYTKGSFTWADRFMHPAFVQAESAKAAGATEAPPIPAWMRREYFSQNLSAILLFCGVSEETVTAWSTSSYTFMDHYNMFSKVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWZ4</accession>
    <name>A0A088RWZ4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chaperone protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_310490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701438.1">
        <property type="nucleotide sequence ID" value="XM_010703136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWZ4"/>
    <dbReference type="GeneID" id="22577475"/>
    <dbReference type="KEGG" id="lpan:LPMP_310490"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310009900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_310490"/>
    <dbReference type="eggNOG" id="KOG0719">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052423">
        <property type="entry name" value="EMIR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44094">
        <property type="entry name" value="DNAJ HEAT SHOCK N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44094:SF8">
        <property type="entry name" value="DNAJ HEAT SHOCK N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="277"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="569"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="569"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="595" mass="63661" checksum="B5A3E9C9CCD26278" modified="2014-11-26" version="1">MLLISWCLTNWKLLTAAFVAIVFFFGRVKALPQKDAPSAMERPTAKSAEGGSPARGPAPPPSTGAPTSNAPAASPPAASDSGGALAQGETDSPIFEEITSLFASRNPKHALQGLSDGLRNTATGIGLGLAGVVAGTYGGAKEGGWGGMAKGFGAGMAGFVGLTGYGAYAGVRQIVRGVSNTRSAVSEVSKGEAYWDSNAEAWVRVNLPRDFEGLPQTDEDLLSEARKAYEKAEKDGSRPTMPPTMMPSDSAEGAEASPSPQGVGTGKTEPVATEPVNYYAFLGVEATATPGEIRKAYTRKALEMHPDKNPSDSNATIKFQELNKIYNVLSHENTRVAYDRYGTVDPANVPEMTGNPMKELLGATFLEALVGPLHFFLVFEGRVLFTAEMQRELHARRRLRVAKVLLLWLDNGASGFESAHLVLRDAVSTPLGPVFLSYVAEEYHLASRQQLYGNSWKREVDSWYSSWAMSASSLWHWTTIGARTARRALVDKNLGEEDILRVLAVANERDVRQIVLQACRLVLFDMSVTPEQRLGRAMRLEELSVMAMEEVAREVASRESVATIATSETAAAATANGATTQAPAETSNATASPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXD3</accession>
    <name>A0A088RXD3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Single-stranded DNA binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_310450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701434.1">
        <property type="nucleotide sequence ID" value="XM_010703132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXD3"/>
    <dbReference type="GeneID" id="22577471"/>
    <dbReference type="KEGG" id="lpan:LPMP_310450"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310009300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_310450"/>
    <dbReference type="eggNOG" id="ENOG502S32Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269552at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097196">
        <property type="term" value="C:Shu complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28653">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28653:SF1">
        <property type="entry name" value="ATPASE SWSAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO00634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="242" mass="26299" checksum="86958A202C2A869D" modified="2014-11-26" version="1">MAASFRDCASHPSLDASIFFPEGSRPPQPLHGHGFLLHGARAVGKTSLAFQAAINTVQRSDGSVVVLCQESTLYSKVPQPFTPLRSLPESTLGRIEFIYVEGWTAAMREMMGFRTTRAVPTLVLVDDDGFEVTAPADCRGKRIGRHSDVLVATAAASCLSYLENLHDWMTRHGHPFFYVLVTNRLPESATQLSLPYAAFPLVNVWVGASGTVQITPTPADNTAAVVAPAVYLTWQNGLRMRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXE7</accession>
    <name>A0A088RXE7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">CrcB-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_312450</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Fluoride channel required for the rapid expulsion of cytoplasmic fluoride.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>fluoride(in) = fluoride(out)</text>
            <dbReference type="Rhea" id="RHEA:76159"/>
            <dbReference type="ChEBI" id="CHEBI:17051"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:76160"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701633.1">
        <property type="nucleotide sequence ID" value="XM_010703331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXE7"/>
    <dbReference type="GeneID" id="22577671"/>
    <dbReference type="KEGG" id="lpan:LPMP_312450"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310032000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_312450"/>
    <dbReference type="eggNOG" id="ENOG502T650">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="409792at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="FluC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="FLUORIDE EXPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259:SF1">
        <property type="entry name" value="FLUORIDE EXPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIO00833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="28446" checksum="378037C20532813E" modified="2014-11-26" version="1">MESLNEHCTVFSHDDGEGRNSTASRNEQARYSSQPPSLPAPSATTPYTDSWPPCVLLLVSCLTVAAAGIGGNAARVAMKNCFAKSHFFPKYRYIGPNCLGSFLMGLFVVALPPEAALPLTHRALCVGFCGSFTTFSSWVVQVMAQDTATDAFEHPFLGGTMPVVFFLWGRDCGRGVRWFYAHVTASPWGTWPSHRSLLRVTDAALFVLVALAAILALVLVQVSINEGGIQVISSDDVRVVVLAPAGAVVRFLLSFCWNKKACVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXI8</accession>
    <name>A0A088RXI8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_312960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701678.1">
        <property type="nucleotide sequence ID" value="XM_010703376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXI8"/>
    <dbReference type="GeneID" id="22577722"/>
    <dbReference type="KEGG" id="lpan:LPMP_312960"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310038000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_312960"/>
    <dbReference type="eggNOG" id="ENOG502S2GJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271501at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499:SF80">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO00878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="36912" checksum="092BA1B003F1ADBB" modified="2014-11-26" version="1">MESDEELPAAVANTSSTAVVRGMSSTVLPHLLLASAMGCCRESDSLAELCARLRRRYEALSTLPPQVPPVVCFYVGGTRFAVSRSLLEKDPGSLLFSLATQHYCSASSAKGASDARLRGCKRYRDGNDVMVSDAIIAIPGRNARLFGMLLNLLRGYRNAIPEDWMDSCREEAVYYGLSGSWNTRFHITSSKYYFRNSLHNSKLVSDAVLGVASDFFSTGQHHIDFSVSQCDRVAVGMISSNVNAAEELAAPLQEGNNGAFYWNDGKLSFYLGESRVVETGLPFPAGAIIRIIFDAEERIVRWIVNGEYCVAMERLPAGRQYAFGSIAARGSQVTIVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXU6</accession>
    <name>A0A088RXU6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_321010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO00988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701788.1">
        <property type="nucleotide sequence ID" value="XM_010703486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXU6"/>
    <dbReference type="GeneID" id="22577842"/>
    <dbReference type="KEGG" id="lpan:LPMP_321010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320015200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_321010"/>
    <dbReference type="eggNOG" id="KOG2039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10023235at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031332">
        <property type="term" value="C:RNAi effector complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000018">
        <property type="entry name" value="Serine/threonine-protein kinase 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000080">
        <property type="entry name" value="Staphylococcal_nuclease_homologue /Tudor_domain_containing_protein_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000081">
        <property type="entry name" value="Staphylococcal_nuclease_homologue /Tudor_domain_containing_protein_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000062">
        <property type="entry name" value="Tudor domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016685">
        <property type="entry name" value="Silence_cplx_Nase-comp_TudorSN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302">
        <property type="entry name" value="EBNA2 BINDING PROTEIN P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302:SF2">
        <property type="entry name" value="STAPHYLOCOCCAL NUCLEASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017179">
        <property type="entry name" value="RISC-Tudor-SN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TNase-like" evidence="7">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="7">
        <location>
            <begin position="170"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="7">
        <location>
            <begin position="359"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="7">
        <location>
            <begin position="543"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="6">
        <location>
            <begin position="753"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR017179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO00988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="933" mass="102594" checksum="D17CC1EF72A8C2D4" modified="2014-11-26" version="1">MSYVVYAVENADRMILMGPTVADQPTFKAITLSYIQAPKLARRMATGEFTPEEPYAYEAAELIRSTFIGKQVQFVEDYYIEALQRSAGRIMGANQQEATGMLLKEGLATLPDRMPPRIEKELYEIYSLMSAAARAARKGLFSGDGDKHVRQMKSYTPEELAEKIEGIKGQQLLSRVEKVLSPTLLIISVKELGDTQFAAHLTGITTKDNGNESINTEAKFFIERLLQNRNVKVRYDGLDGFNNVMISIMSPKGSFQEELLSKGYVKIQNATLPLSTRIDQITSAEASAKKQRVGCWKNYVEPAGVAPSETAECEWGPHPPCAIGEDDQMDAKAPAAPRVAGLPTTLPDGTPGPVYTGPIEFVGTLVQVVHGDTVVIRDDASTELRRVSLAGVRSSKNIDRDQDGNSPETRVTYNDYSWEAKEFLRSRYIGSKVVVFAEYARVMPETKEIRLAATVQVKHTGINIGVALLEAGYATFFLGRNDKHSKAGELAAAEDGAKEEKKGVHRSTPAPPMKVLELNHLGETRGRYYLSFLQRGMQGNRPPPLKGVVDLVLGPSSLRVYIPKENFQIPVKVAGIMTPSAAFRPNDKADPFAQEAKDFAIDLVQQRSVTIQVFTSDRAGNFISSITLGDGTNISVALVAEGFATVANTDRLPFAQQLMDAESAAREAKKHIWSAAGAIPQRAMKMEQERAANNPHALTRVLDETSHFVPYVITNIADDGLSVHLQGYDEVQDTKKGQIQCLLNGTVARESYTPKKGERVIAQYSGDKTWCRATVLKAPRDGKAEVQFIDFGNTEAVPVQNIRAVPRGPEYALVRETPAFAKLARLAYLKSANQDEMLAGVACEAVEEYSEGEVLAKAVYRDGFDQVYYTVATNENVPSLSETLLQRGLALLDRRASAVNPADYRLHEAAQEIARKGHKNLWQYGDIDEGDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXZ8</accession>
    <name>A0A088RXZ8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_312290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701616.1">
        <property type="nucleotide sequence ID" value="XM_010703314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXZ8"/>
    <dbReference type="GeneID" id="22577655"/>
    <dbReference type="KEGG" id="lpan:LPMP_312290"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310030200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_312290"/>
    <dbReference type="eggNOG" id="ENOG502SNJ8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="261468at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO00816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="203" mass="23036" checksum="0A827CAAB5CF5CFE" modified="2014-11-26" version="1">MEEFKTQKQSSRNAGKWSYCVLSIHSQLGVAAITDCDNADGGFYQCMRVANVQIWPQYSKKHIKEKFVSMEAMLTVRVKGIPAKVGVREAPSATGPTKIYSYTMRGPEAKKHTWMLRFSKYEDFEGAMNLFQAMKVSDLHLSVTKRVEGRQQTKELEEGTVEVDLSELAPRTIIYGNLNEGLAPIRAEWQQKQLKGSRPKSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYI8</accession>
    <name>A0A088RYI8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">U3 small nuclear ribonucleoprotein (SnRNP), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_301350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701165.1">
        <property type="nucleotide sequence ID" value="XM_010702863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYI8"/>
    <dbReference type="GeneID" id="22577189"/>
    <dbReference type="KEGG" id="lpan:LPMP_301350"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300018500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_301350"/>
    <dbReference type="eggNOG" id="KOG2781">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253204at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000008">
        <property type="entry name" value="U3 small nuclear ribonucleoprotein (SnRNP),putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF2">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Brix" evidence="1">
        <location>
            <begin position="83"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="288" mass="33175" checksum="5E4DCAF4975AD71F" modified="2014-11-26" version="1">MRRSVIRTRKEFLERKQHERVHEAIHARKEQFRNALETTTPLPGHLKKDALALKKFTELDDAQTRHLATTVDDEYASAGQEDPHVLVTTSRNASQKLLEFAKEVRLIVPNAVRMNRGSLSVHQLMYAARKENYTDVVVLQESQGVPDSLIVSHLPLGPTVTFTIHNLVARHDIDGVGTMSEQYPHLIFENFSTKLGLRIKDVLRYLFPVPKADASRVLTFDNENDFISVRHHTFKKEKGKRQVELTEVGPRFELTPYRVMLGTLEMDDAETEWVLQPYMNTAKKRRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYJ6</accession>
    <name>A0A088RYJ6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_321350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701821.1">
        <property type="nucleotide sequence ID" value="XM_010703519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYJ6"/>
    <dbReference type="GeneID" id="22577876"/>
    <dbReference type="KEGG" id="lpan:LPMP_321350"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320018900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_321350"/>
    <dbReference type="eggNOG" id="KOG1471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1434354at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051064">
        <property type="entry name" value="SEC14/CRAL-TRIO_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23324">
        <property type="entry name" value="SEC14 RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23324:SF83">
        <property type="entry name" value="SEC14-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="375"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="760" mass="83990" checksum="FC993678772F2AD0" modified="2014-11-26" version="1">MIGTRSPAVEGAHAYKDSDLLSSTTDCIQLSSKDENCVTEAIKVLQQTLKKSTVNSGTSTTSTDEATDSGIAVEHLADFSHGLMPGEARYIVYRYLKANDMNIPRALESMTRSTERRKKQSINKMALFPCLIPMKGFDQRSICDELGLPFINNISTSMRCLDAEGRLQLEREQLNDCNVHHEELYANLMTPEGTAMSGPTNRELSDRLSSESSESRSPAASSSVLTADRANGKSTLERDDSAETQRAVESENGHSPSSERRGKGNGSKHSGSMWRSLLSLIPFDRFKSTTRSPNSSISPLQRRSSMATETRRHSRFHSILSLSSGRSDGEEEQLETAGLNEMEFLNTAGAAVPPPETPNTLYADCLNFHGILEPIVAVITKHVPFAFHYWDLEGHPAMYCRLGGMDSKKLMQELFGLTPIDAEPRALAVLFNTYALLVVEQLIRYCNRRNRGSDEGCNALLSPPQRESGEDQDRASSSPLSTGSLGQKKPRVGSCIIVIDCAGLKVRRCLYKPLFVMVRSIVRMNTYHFPELVHHVYVTNCTNVVSWSYLMWRGILAKTTRAKVTFCSKHNTAATLCENISRSFVPQELGGECQCPGGCIPSVAVSFSGANSSPLSRSNLDVQSSPSTQIGESSTDQATQWFGEEALVPRHLLCTAKRLVLKARESRKLSFAMNEGSEIIWEFAVKHRRDVTFSAVFISADNDGAMLSLVPRRRVQNEAGHYICSSIGTAIFEWSNKHSFFSRCQLSLKVYHEDVSVASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYK1</accession>
    <name>A0A088RYK1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_321400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701826.1">
        <property type="nucleotide sequence ID" value="XM_010703524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYK1"/>
    <dbReference type="GeneID" id="22577881"/>
    <dbReference type="KEGG" id="lpan:LPMP_321400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320019600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_321400"/>
    <dbReference type="eggNOG" id="ENOG502S684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="250375at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="552" mass="62216" checksum="EFF9E1A4B9A7ED3D" modified="2014-11-26" version="1">MKALSSVSVDGIGVEDGIYVNFFSVDGKAAMLACDMYGVLPQNLLYLPKEMFLQTRDESEQIVLVRYTMCERSRQGTFRTLLGAKSKLIAEGKVEALWEERCRALPDAAPRPRFAEQQLKEATTAFDTDSESDSEQQIDERGMLKPPPPPPSSAPPFTFAGPGNEAAAQAAASEEDGLPTAAINTPYGGVQDSNSPPPLRTQASSDAACETRIGSNTAVTTDNAMPAVDAQRMTQQPYGDWCQYKLVKPLPLPRRRHLRTQPPTLPKPYFPRVCETLRIEEAELAVAQHELSRYTTKVAKQLQARQQERFSGLHTHGHSTSLPPLTFSLSHSTTGTHLPQSVELRNRREHAAIMRVAQLRVCSLNERYEQARSIGEEMEAIPTLGTLEHMLKYQQSIGVTPEFEDRIQAKAEREESLAAARQAMREAEWERVYAMEEKAQHAKEVREVAHEKTKGIAAEAQRVQRLITMWKQAAAIRQQETHLNQILHRSAVRHAKADTYIEAKRASASMLRYHHDQQEMHRRQLRNMIRDMMIRKNFAADEVTDWEKDIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYL1</accession>
    <name>A0A088RYL1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleoside triphosphate hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_323240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702008.1">
        <property type="nucleotide sequence ID" value="XM_010703706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYL1"/>
    <dbReference type="GeneID" id="22578065"/>
    <dbReference type="KEGG" id="lpan:LPMP_323240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320038900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_323240"/>
    <dbReference type="eggNOG" id="ENOG502RJPN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020859">
        <property type="entry name" value="ROC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47679:SF2">
        <property type="entry name" value="C-TERMINAL OF ROC (COR) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47679">
        <property type="entry name" value="PROTEIN TORNADO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08477">
        <property type="entry name" value="Roc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51424">
        <property type="entry name" value="ROC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Roc" evidence="4">
        <location>
            <begin position="57"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO01208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="824" mass="93320" checksum="308B17C148176080" modified="2014-11-26" version="1">MREQTKGQSLMARYVLQNAARDEAHNSSFSATATTADTHHPRGIMKLVQSVPRLRFRSQQVHRRKITLLGYQEVGKTSLRKCFESEPFFFKDLPDVRTTTGVEVQEKSMTIDGDTVHLILSDFAGQESYHSHTYFLTERSIFLLVWKLSAVEQDFQSSGINAREEERLQRWIAEVFAKYPHARIVLVATHLDELRVQGQRSVEMILNKVEGKLRSYIDDLIAASNATAAPTPGTPALTSSSTTVGGASSPSKEQTLLHLAQMRDARRVIVGNFAVSCKTRLIIAAGNALRHLSGQKISGLLRYLGMVVKEDCFADREYPAAVVPGRHVKLIESLEDMKRRHPFKLLMRLGEFVQMAVNVGIESERELLQVARLMHSWDIIYLFNQYSMEDNLLIVLYPRWLNRMSASLFSYAHLLRTPLHMRSMIGGLEYLVSNAEMADMCLMRKGYLRWPLARVLFHKPLSDFLRHPPDDADITMCLELLESMQLIYPVEVECDEFEVLVEEVPVNPSVGCPVVESQKITRYYVPSLAPLETPQSLKKLAPVLFHRGVRVRLEFNLLPDEFWWRFQCKLHRFIKVVTVYQPALGGVDDEDLLLNGFRLREADEEHNRWRDSLWLMGRGCRVLVYRDGANAVSVLSAENTPRGSEEVLQAMEDALTALLRHYKGVQRRTFVACPSQDCGGWLEADVVASSVSITCPTCKQTFDSKQVVSSGVGPLGAPRFSQTLLVEAGELLAFCLSHQSCLHMCRYLGIPYKGPSPARGESVEAAADSESDSGQADVLGTHVEYLHALDKVVQAVLFRSWMQRTEEQERRRRMLEDEPTPAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYP1</accession>
    <name>A0A088RYP1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_323610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM161 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702043.1">
        <property type="nucleotide sequence ID" value="XM_010703741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYP1"/>
    <dbReference type="GeneID" id="22578102"/>
    <dbReference type="KEGG" id="lpan:LPMP_323610"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320042800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_323610"/>
    <dbReference type="eggNOG" id="ENOG502R6KI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2150121at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044782">
        <property type="term" value="P:cilium organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051655">
        <property type="entry name" value="FAM161"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019579">
        <property type="entry name" value="FAM161A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21501">
        <property type="entry name" value="PROTEIN FAM-161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21501:SF1">
        <property type="entry name" value="PROTEIN FAM-161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10595">
        <property type="entry name" value="FAM161A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="274"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="345"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="473"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="671"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="285"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="358"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="369"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="674"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="704"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="726"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="793"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO01243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="805" mass="86476" checksum="58D2DFE9046B891A" modified="2014-11-26" version="1">MRQYFSSVGDYQGYKERREKSMKHVKPFAFESRELIRPLRIREKRAEAEQHAREVAAAKHRKPYKATPVPPSTFMNKYELMVEEWCQRKAAIELMSRERARIAKDEAAFVRLSAQGLRSTREALMGVVYGANGKPVTRDELRRRAQSADVNGNRRNGPEVPHREVPLEVRMKLWPAISDHERLRRERIKFLAAMRKSEVDAEVRQVMPLLTSPSPARCYDAASLGSTDVAALLAATKSEKASAAAPCYGVGQAVLSFRPNPLLDAEAVSMATAPLPSTMPPPPAAASTSSPLRAAFPSSPSITTPQPPAGVAAAAPTPSLAAVPEPPPGAVVPLPLPLGPSAFTTAPQPSLFTGGAVPAPPSAGPPSLPLTTSAPSPAPTAPVAAPVSSATSGAVADAKVAKPGTQQDREAAWRRYNPQLTFKPNVRPGVPNFEALWAHNKAVLAQKKRQHTTTVPRPFDLTLSARDSKIVGRRPVRSASALGPPYRHGSPSGGRRRHAADTPPTSARDVTALPSPLSGAPRGTRAHALRTQAIYSNYVKQSEEHSLTAEGDAQYWKAVAQRQREVRKRLSAYLVDHHTEHERTIREKVRSLRAAMRESEKAAAERLAEIKQRVAEMPPVFAEPAHLNEQSKARVEAEKIILQSLNEAGLDGTTIKRILTYPPVAAADAATDTFDTREADVNRNEDDGAPPTAPGEEDSKPRGAQSSPTAHSPLSDQSKPSKHNSSDSNDSSSSSSDRSISDSNSSSSSSSGGSTKKSPPGSSVSKRSLCPSISMLSVPVPKPVAATKKDATDYSDDSFESSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYW3</accession>
    <name>A0A088RYW3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_322640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701949.1">
        <property type="nucleotide sequence ID" value="XM_010703647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYW3"/>
    <dbReference type="GeneID" id="22578005"/>
    <dbReference type="KEGG" id="lpan:LPMP_322640"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320032600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_322640"/>
    <dbReference type="OrthoDB" id="273488at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="264" mass="28162" checksum="BDA793F26F1823B5" modified="2014-11-26" version="1">MAHATHSPRYSGNNVIVGPPQLSAADSEGARLVRFSLLYKLRHRAYSITARNSISSERAQSWPSPPHAAEQYGHCTAYGNDTSHGETGEAAGLGYMTPPQRGSRPTSTELFVRHSPSSVALSPLPSTNAAVPLLSTMDKRELSKVVVRDAVFGRLLDLVPSRQHIQTAIWTLSSNVIQIDGAVAVRAMPRDGCNGHPFSDASHLVASRGGSSAYADVEGLCDVVRERVGELVVDAQFFACLLQPYLGDIGCQGDVIQASVDVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYZ2</accession>
    <name>A0A088RYZ2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_330800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702173.1">
        <property type="nucleotide sequence ID" value="XM_010703871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYZ2"/>
    <dbReference type="GeneID" id="22578233"/>
    <dbReference type="KEGG" id="lpan:LPMP_330800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330012500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_330800"/>
    <dbReference type="eggNOG" id="ENOG502RWNC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272474at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="707"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="771" mass="85018" checksum="F031DA566F89D32F" modified="2014-11-26" version="1">MWMRMHPVERWTALVDLGRRGAYLIEKPVHLLSPGARDVGEKWTPISETNPDNLSVLGGADPKVRFTWKATVAHWHLCDVLPYAARLHLCLSLLLWIRCLRDVQDTLARVRLPFAMVRRPQRYAVADVFPTRLSEHWIDAHTTVSTKMSAQLNSTAEQIPAPHAWDPETSETMEDAAMEATMTLDAGHVLHGRHQARLGGKKLLQQVQGVQPRASADDDMAARLTEAGSLGGRRRRRRRLLRASSSSAPNALSVGSVPASSRWRSSLEFACDASRRVPPVSLEPEPLEDAAYHGNDNRGEGCPLNQDGTASPAPIFIYVPPNVHNAAVSPGGARSTEAELLVRYCVMAHAAVLSSLFIEGRVVDFCSNHPLVVAYVQWLLDELVLGRFVSVSVLAEGEVTAYRSYYPPWCWSNVLVLMPPKHCSSYSPVVLRDWAARIVQAAPCSVLVEGSTSAGYVKQLKDEVQLLQSALDAENTRAVEWVTLSATVPIDTTTRESASHVAGAAASDGNHNDKEEAKVPQFQPQRCPKAAPSSLALASEATFASVQWLGEWLKSGSSGATAHSTFHQAPFLEAVQEALEDRFYTCELLYSPTQSCLTPYCFERWVLEQLPGNVRVVGINTSPLDVLYFFPQGVFLSQKVGNAFRYRAVERTVVAKDVIPTWSSHPLRYTATQLRRLSRCWRRRGDDVASGLHAEFSPSDIPKLKSTVRAATSSTHTPDVEPYGDARDKAAESADEENASHALVRERMVEYLAEPSKGALLGLAVARFFHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZE6</accession>
    <name>A0A088RZE6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_330910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702184.1">
        <property type="nucleotide sequence ID" value="XM_010703882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZE6"/>
    <dbReference type="GeneID" id="22578244"/>
    <dbReference type="KEGG" id="lpan:LPMP_330910"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330013700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_330910"/>
    <dbReference type="eggNOG" id="ENOG502S1JG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="278802at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="485" mass="52629" checksum="199CBDFB5BD498C2" modified="2014-11-26" version="1">MENPFEALRPALRSEEDEIRKGVFSQALRNLQQASLEERRRWCKAIRESTTRGSAKAKKKAISAAAVAESSDNTGTSAPIASPPQRTPSNTAASASPPTMSVLTAAPPTQEVHVAVGQKRARSESETSPTGFPATRLSGPLEDPLMPCAPQTPETMPEATIVSSQPFLTGVLAPANGEPSSGAAASDSVAEETEESIKECIAAYMRSLLDRVVGTGIDNLAVPALKVLCMMLGIHTEVSSKLGLYSILADFYFSKCAKLGKRVSHETAFEQQVSIAKRMTSVSSSSALTEKKVAPEKAAVSITKSVVPLSDKAAKTEVRRKEMVERKKTLSAPLPNPKRAAKALPRPDPVTEHYLKYENYNGDTFENDAAVATPACSHQYDGNVIYQQPVFTRPSNQTVLPSHMAKYERSGAGAEEDESWPLPLLERKVASIVQLYDPVTVAIVVKKLTQMGYRDGGAESHVEQILRRFHERQLIFYDNGIAYLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S005</accession>
    <name>A0A088S005_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chaperon protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_312980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701680.1">
        <property type="nucleotide sequence ID" value="XM_010703378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S005"/>
    <dbReference type="GeneID" id="22577724"/>
    <dbReference type="KEGG" id="lpan:LPMP_312980"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310038200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_312980"/>
    <dbReference type="eggNOG" id="KOG0714">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050817">
        <property type="entry name" value="DjlA_DnaK_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="18"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="217" mass="23976" checksum="0DC0BA131238BE8B" modified="2014-11-26" version="1">MHRFSRRLLGAAGIGPFDPYKILGVSPGASKEEIKRAYHRLALRFHPDSGAEGNSERFAAVNEAYEAVKDGKWKDAAQQQQKAGAQSGGGGWDPKRRMYVYEQPGSTTDGYVSGDTEKYLRFFMIGCFLFIFVRVSLFFFLPAKKHDGRQESAPGQECSDGSVPLGSFGGQETTFAPSLANVASGYRSGSVHADEEMEYKWVENNTSTSMKDPLSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0T5</accession>
    <name>A0A088S0T5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_341850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702611.1">
        <property type="nucleotide sequence ID" value="XM_010704309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0T5"/>
    <dbReference type="GeneID" id="22578690"/>
    <dbReference type="KEGG" id="lpan:LPMP_341850"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340024500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_341850"/>
    <dbReference type="eggNOG" id="KOG2865">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275457at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05271">
        <property type="entry name" value="NDUFA9_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000538">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase complex I subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF11">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO01811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="373" mass="42755" checksum="1B89D303EB7DD19C" modified="2014-11-26" version="1">MSRRLFVRNMNGELSSTWRHGGAEANTMGVNVATFGATGILGHHIHAVNCYHGYTSILPFRFRAGMPSSVRQMRSSGDGTVGQNFDTDYEIDKEFVVKAILEKVDNVINVVGAWQEPACYENSQSWFSMEAINVEWPRMLARWCREMGILKLTHMSMVGADLDSPSKLLRQKREAEIAVLEEFPTATIIRGTDIFAENDFSYSKYLKAQRYMKIVPVPNHGQRIHQPVFAGDLAEAAARSLLLDHTEGRIAELGGPVRFTTNDLLRWCSECNNQRHLTVHLPKIVFDIACHINERYPIHQGILLGTKAPTWNKDWVERQFIDNCAMPERDPDLLDWEDFGIPREDLYRMEEKYFITSVMWSKSSPYLDYANRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0U6</accession>
    <name>A0A088S0U6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-directed RNA polymerase III subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_344060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702828.1">
        <property type="nucleotide sequence ID" value="XM_010704526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0U6"/>
    <dbReference type="GeneID" id="22578911"/>
    <dbReference type="KEGG" id="lpan:LPMP_344060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340047900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_344060"/>
    <dbReference type="eggNOG" id="ENOG502S2HW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5836119at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007811">
        <property type="entry name" value="RPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05132">
        <property type="entry name" value="RNA_pol_Rpc4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="58"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO02028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="364" mass="38309" checksum="F45DEBDA66D1C87D" modified="2014-11-26" version="1">MPPKAPNLKFKPKLVLGEEEATARSLATQSTDDLSLVQLARLQGLYIEEQALSASGAVTGSGDRLTLTSSSSGRVGSNGGRGGVTGSSSTPCEEQPRVSCANGLQNEDGRRGTVASSLLRPKSRGHNLSAHAALEEASRRHVDISQYPETAPPLPQNSMNAIVSSSASQCSGSTHSALYVPLPLDATLPTRFAAEERGDLSSAQGAVGGAPRSPSAAPMDVDGTAFLREAELEQERTFAANMRFYEEILRPMQTVVPSAAVAPGGLVWMQLPRFHENAPFSFFNLPPGKVGEMKVLRSGRMVLEIAGVYYDVAVEGYEDAGNDGACATAVATQSSAYPSNPSSKPSCYELGLLQKKLICTPTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S163</accession>
    <name>A0A088S163_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_020110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009371">
        <property type="protein sequence ID" value="AIN95191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698156.1">
        <property type="nucleotide sequence ID" value="XM_010699854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S163"/>
    <dbReference type="GeneID" id="22571821"/>
    <dbReference type="KEGG" id="lpan:LPMP_020110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_020006100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_020110"/>
    <dbReference type="eggNOG" id="ENOG502RZNV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:001138">
        <property type="entry name" value="Ankyrin_repeats_(Many_copies)/Ankyrin_repeats_(3_ copies)/Zinc_finger_-_C3HC4_type_(RING_finger )_containing_protein_-_putativ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201:SF15">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="835"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="188"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="776"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN95191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="891" mass="94565" checksum="AC54350E07DC0970" modified="2014-11-26" version="1">MEFRWAAEGNTEELRQWLREHPERVNVPAKGSNMTLLYTCISNVNRTDLASIQAGYSGYLRTVKMLCQEYKADVLARNGSNHNTALHLAASIGATSIVRYLVESLQTPVGCTNAFGERPLQLAERHGHTECASILAAATPTAAVAQCQQSVGDCAMPSEKAPLGGPYIGTSGIPSGGIGRFQKLAISDSDDDDEKPSQNSNSRGAPVHRASGFPFRQPGDGAGPFLPATQLKQGGGSGTRTAPSSVVDGSPASLLPGEAHSALQNRNLNGSRSGTTPTSFTPSTPIGALSNSTTFSGLPPPVRPRKEYDISDSRILANPDLQGFRFAYGDGFRYIQCSDHYEIRGILPYTYRGTVYYTPVIISVYAPVSGIDSAENTISVSNAADAALNESNKLSASLASANASASQTVLRASCVKAKTGVYCRYRVCLNIENLNGFAISRKAEYVDPISGAIIPAPGDDKYQTLTAYIRNVVVRNFEAMPPLIVPSSIYAFPSRPNISQLGSSGSTDVYRHHHSHNAPLFMRNALPNRSAEHLRCATVLRDLSKFGDGLARYFPAKHRIVAYVPIFSEHKAAVLAIPKERPYATTVGQSPSLTAASTAAAKTCSAEVTVSTAGGKAGVTHQVAVEAVAELQVRVVLQFSPTRIGGTAGESGGAHDSEACVYAKPPRLYLVDAATRPLGPFLDGAAFATTTAAAVTGAPASPSSSPSLTGQCFAGIIKDRETGEVTPELLPLSQELWSANGSVYDVLVELQRVLRGVLESFAMSYAGVKGTSLQESLQQQPLGSSDRRAGAPRNAPAAPLTLNSFMTPTMQGQPFLTEVSGDNISAPQRSSAGCCLYCMQMLQPSRILLQPCGHNGLCGLCVQRLQSHCREEVFACPVCRGAVRDVLEIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1A9</accession>
    <name>A0A088S1A9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SP-RING-type domain-containing protein, putative</fullName>
            <ecNumber evidence="7">6.3.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_343840</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.2.-" evidence="7"/>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702806.1">
        <property type="nucleotide sequence ID" value="XM_010704504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1A9"/>
    <dbReference type="GeneID" id="22578889"/>
    <dbReference type="KEGG" id="lpan:LPMP_343840"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340045700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_343840"/>
    <dbReference type="eggNOG" id="KOG2169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27975at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16650">
        <property type="entry name" value="SP-RING_PIAS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF96">
        <property type="entry name" value="SP-RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02891">
        <property type="entry name" value="zf-MIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="6">
        <location>
            <begin position="494"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="91"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="607"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="630"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="653"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="688"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO02006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="709" mass="77252" checksum="EE0358645CCE62C1" modified="2014-11-26" version="1">MRGMSESDWRRLHSRVIPNRVPLLEFKSIISDGTVHDHYLAKDLHKIMQELRDLLYEHGELREASVLPLTGRKQELSRAAATAVRLIDSDRDGTPALRRSPDISLTSTRALGGHHGPTSPTFGSASDLRLSDCRRGSTEDALSPQLLQTTASALLISPRRSSRVLPLTDHIQEEGQPQISALSLSTALQPTVSLPLPPIASSTTSSSPACTREADVSRGGSTYLAHTSAGTVSLGSSTRLSTSWTTKARTASTVAHNAATPHASVGAPSTSSVATTVPPSLLTVSLSTSSSNEIAQLNESAPPFFRILSVPRRFQLRFGSSTVRFDIPVQYVDAVNSRQLRVYMIPLRHPNTPARWPTAKEIVVYVNKQCVMTPWKRSWPDREREVAETYLPLDITYLLSRNTDIQHVQVDIHNKEYQTPAILAVVQLRSLEEVTESVLSSRLGCRTAVQARQVLLSSLSSADALTSTSSAGLLLSNNAAIYRTYAAIMADDEDDDGLEMDDPVITTKCPISQLPLFVPVRGSRCTHLQCVDLDSFLVSSNKASYWNCALCDAEMRPCDVRVDTILWGYLCTFASADAYPLYLRLSARTAPKEGEARYHWHPSTRTGESADVILDDSESDSEIGRRRDPPLASGPPAASVGASSIEAAAPCSEATSVSASNRAQLPMPSAASHRDKTWAEGVGHWRKRDRDDNSPTEESRGTADDPIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1C5</accession>
    <name>A0A088S1C5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Intraflagellar transport protein 57/55</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_330670</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IFT57 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702160.1">
        <property type="nucleotide sequence ID" value="XM_010703858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1C5"/>
    <dbReference type="GeneID" id="22578220"/>
    <dbReference type="KEGG" id="lpan:LPMP_330670"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330011300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_330670"/>
    <dbReference type="eggNOG" id="KOG0972">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="423881at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019530">
        <property type="entry name" value="Intra-flagellar_transport_57"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16011">
        <property type="entry name" value="IFT57/HIPPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16011:SF0">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 57 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10498">
        <property type="entry name" value="IFT57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="157"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO01360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="33916" checksum="5AD9F92620DD3988" modified="2014-11-26" version="1">MNIAIPNIAPTRLKQGSGEAVLAVLSALVNAAISGAGYDFQPIDYSQVSRYDELAAVADAEDEQGADEIEDNVVIDSDDDDEVYVRAVSGSRNAKSDADRPPTPKVDVEEWKMEVERVAPLLQVRQSSLDDWRSRIESATVLFKAVENMYPDVKQMLERLASDMDKSRDRIQKREQTLAQQFSDQVEDYRVKLRELNTSRDSANVAQQTVQQMSVELNQISELLDQTKRDIAERQAKISDTTPLIQVKEAVVKVQAEIKLMSLRIGILQNGVLQHVMKQTKARREGQTIERADMYNGGIMFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1F2</accession>
    <name>A0A088S1F2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3CxxC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_344240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702846.1">
        <property type="nucleotide sequence ID" value="XM_010704544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1F2"/>
    <dbReference type="GeneID" id="22578929"/>
    <dbReference type="KEGG" id="lpan:LPMP_344240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340049900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_344240"/>
    <dbReference type="eggNOG" id="ENOG502S2F2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="274693at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027377">
        <property type="entry name" value="ZAR1/RTP1-5-like_Znf-3CxxC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13695">
        <property type="entry name" value="Zn_ribbon_3CxxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="3CxxC-type" evidence="5">
        <location>
            <begin position="25"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO02046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="114" mass="13498" checksum="E3700B343E96219C" modified="2014-11-26" version="1">MLRLTLLLRLRPRHIMFTPPPLAKRTGKFRCKVCQHCWFSDEVWVTKTTQRVYQGESCEACGTTNKPYYVGRPEETIFNSSHTPHPVKRGVSSSRSERKLRHSRFDWRVQKGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1Q3</accession>
    <name>A0A088S1Q3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">COPI associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_040980</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="AIN95421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703743.1">
        <property type="nucleotide sequence ID" value="XM_010705441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1Q3"/>
    <dbReference type="GeneID" id="22572057"/>
    <dbReference type="KEGG" id="lpan:LPMP_040980"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040017000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_040980"/>
    <dbReference type="eggNOG" id="ENOG502SB28">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267204at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013714">
        <property type="entry name" value="Golgi_TVP15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28128">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28128:SF1">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08507">
        <property type="entry name" value="COPI_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="210"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN95421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="30751" checksum="4683BBA56BD0FAEB" modified="2014-11-26" version="1">MFTTHSAQSRAQANQSCWVRNWPRAFLGMSLAVVVLSFVGIILSFIKIIYSPNVVLLNVYCLIFSLLGLSAELRQFSVLRRVVYKWMKYFYFLVYYRARGIFYILFGILLLGNGTIETVGGVVAIVLGVLMLLVGVGVGLPEFEDAAEARRVQEEFQRYYGGGSSSSAAPAAASVPAPASSATNNCGQAETLAVPAGANLYREYNFGDSPLREEPTAISNPKSSANPYEEERGLQREGPNMFAATVTPPVSETRLTRGESESALKQEFAQAMAKDVEEDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1S9</accession>
    <name>A0A088S1S9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cilia- and flagella-associated protein 91</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_332340</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CFAP91 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702325.1">
        <property type="nucleotide sequence ID" value="XM_010704023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1S9"/>
    <dbReference type="GeneID" id="22578387"/>
    <dbReference type="KEGG" id="lpan:LPMP_332340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330031100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_332340"/>
    <dbReference type="eggNOG" id="ENOG502QRFI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="567787at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026720">
        <property type="entry name" value="CFAP91"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032840">
        <property type="entry name" value="CFAP91_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22455">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22455:SF10">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14738">
        <property type="entry name" value="CFAP91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CFAP91" evidence="9">
        <location>
            <begin position="159"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="79"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="613"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIO01525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="755" mass="83085" checksum="55A52E740E275F43" modified="2014-11-26" version="1">MYRQQRAENLRGGRGYTTEVAGRDRVKFFRRPAEPDNTVLENANYNTNTSTRADAMQAQFAASCPSFSMSSHVAAFSSSVPHSGKAERTLRGRSSAHDWRSPQANSTGGIGGNGLGRRGGAGPRRAKPYHLPAIERADAADGINSGGETQQSGRAAASVQTMYRDNEAQTDPYSPDYFIPEGAPTPEILGLQSLTYQNRGLPAGMEGVQLIQRLRRRRDVEASLPTGTDAASIEAKYIILHELEEKEWAEREDHVAQLQQRRLDRLRQSLLAREAAREDANRERLEQIKSQYLESLGGKLMSLEMRRTASSKRGIDKMVQLKALGGGCAPSQAFEAGATLGIPQVTASMKSAAAVMKSGRAKPSIAAYARYGMAGAPPQLEQDGITGGSRVDARLRAARQAFNYDVRPQLLADSERAEAVDAERGVRMDRVAPKTFVVPENEAVKSLPTLYQRREAERVLHSLEYAYSKLHPSEDAEGGKTPELSAQRVLELYRATPKLQRPETPVLKLEGDDEEEKDEACILLQRLLRGRAVQNDFFDGRERCRGLIKELQAASTAQTEKRLTAQKEKEEALEAEREAEAQHIVSSALGSIVHDTLGFLSQELGRQQDMAALRQLQEEAEVVRAIREAAERARRAEVRQKRDRNEVAYAAYMRATDTTLQCFLDDVTLSAVEETAMAVAVEAERARQAACSSPRHPSTEEEAENIVCDMLDGFVIPAIVDAIELQDREVEKKAVAGAALDAAHKLSKESASPHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S285</accession>
    <name>A0A088S285_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_353830</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NDUFAF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703318.1">
        <property type="nucleotide sequence ID" value="XM_010705016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S285"/>
    <dbReference type="GeneID" id="22579411"/>
    <dbReference type="KEGG" id="lpan:LPMP_353830"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350046300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_353830"/>
    <dbReference type="eggNOG" id="ENOG502RDP5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20681at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05125">
        <property type="entry name" value="Mth938_2P1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1230.10:FF:000006">
        <property type="entry name" value="Protein_of_uncharacterized_function_(DUF498/DUF59 8)_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1230.10">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036748">
        <property type="entry name" value="MTH938-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034095">
        <property type="entry name" value="NDUF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007523">
        <property type="entry name" value="NDUFAF3/AAMDC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192">
        <property type="entry name" value="NUCLEAR PROTEIN E3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04430">
        <property type="entry name" value="DUF498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64076">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="166"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO02518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="627" mass="72530" checksum="5DE03D3C34D160F7" modified="2014-11-26" version="1">MRASVRVRETHRLGWRLRAKRAVESAIRKYVPDPRDNPLTEVPMSSETYSKTHQQQEGSVRIGIRPGQSIEDYMAERDRKWLDQQRLIFEQRIKDDNLPTTKDGLPFVGAGSREHYMDIDSANKLVRTPEPKDYEMDEETVLLRRQLQVENEAEYRKFVAEAKRSDIAAEETQKRRRPHPSDPSYDPFKLTPGYRPQDSTALAQWLKRQRESGKSASGLSLQTKEGQERFYNEEKMATQYNANPFANRIETPRGMSTMRITAYSPDSVFINDKEVIGSCIVTEKGYYHWNVGSFEEVNERTLSVLLHMYPVPDVVFLGTGRNLHFIDEDLRIAFQKRGTVIHCLTTSQACGHFGVQLSVSRRSALAIINPIPTNGYGVECFGDFIENDMFSLSDTQLGISPMRQFSPSLFRQNKVAEKYRATQGTGIGPQYHQLSDGRLVRPGTSYTKLRPMLEPGETVDWEKLPSYYHWYPKEELHDYIENTTWREIKGRPTGEPLEKRLRKAISGGTYEKDEAPAPDLMPWNSATIPITKFPHERNDEEIIVEDPKTGRIIGMERDTYERWKRMMGERCAGLPESDPVEYDQERYVTNKDGVVFDLSKMKYRPIFEGRWNPRRQQSTGRTNPIMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2N9</accession>
    <name>A0A088S2N9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_342090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702635.1">
        <property type="nucleotide sequence ID" value="XM_010704333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2N9"/>
    <dbReference type="GeneID" id="22578714"/>
    <dbReference type="KEGG" id="lpan:LPMP_342090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340026800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_342090"/>
    <dbReference type="eggNOG" id="ENOG502QX7V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="240747at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="CDD" id="cd23655">
        <property type="entry name" value="mS61-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO01835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="291" mass="33207" checksum="EBA8AB17D0EE4123" modified="2014-11-26" version="1">MLRTCRIFCFRIKCGSMYVDYKIMSRNHRRSIRVEDALVDPLLPTTVVPLHWLEQLRCPSTRLLTGYHIEEAVYAKPNYGDRVNSTPALLSSSLAAAKPEESDAHVNAIRAGPVVLYITGQSIPVVLNPLFVHSGEWGLTQSNGELDLRIGMDAIEQCSLYAELRPGGLLYSKLPHPSLTEAMEPVQDTLKRYGMKCGLAESPLVPRPWTRMRYMFIDELQRGPKMTEFVGYNPRSGTQWRFSQHTKYFRTGIWRETIRRNEMNDGLHAHSSWQKSPQQAVPEISFLAPYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2T4</accession>
    <name>A0A088S2T4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_342640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702690.1">
        <property type="nucleotide sequence ID" value="XM_010704388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2T4"/>
    <dbReference type="GeneID" id="22578769"/>
    <dbReference type="KEGG" id="lpan:LPMP_342640"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340032600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_342640"/>
    <dbReference type="eggNOG" id="ENOG502S105">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="186"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="400" mass="44097" checksum="313311DC7D1F6CFA" modified="2014-11-26" version="1">MIFGSALVFLVAVINSSANRYLPAKLKLLAPSIGWFITSVFIARGPFVWYACSLTIQGLFATLLFMTLGFTSSLALRAIIFPFLATAAAAWAKKVLPPVEAWATAAIALVQIWSTFGGLIIHACYPANILQILEQQGERNRRVRSVAGTLVRKQGKFVEGRTVPSLDGKSTLQTLVVKQAYTTPRWVLYCGGNAEFLENSLKDIHVISDALKAHVILYNPRGIGYSTGYLSHLGEFVEDAAAVARAYIEEEKIDEKHLLFFGHSIGGGTAAQVVAECYPHASLVLDRTFSSMSDAAVAFSCLTPTVTRMIFPWFVGNLHTLVGWDKIKHSRKLVLYSQHDEMINFSISSIARHSQFQKGGADADKVVELLGAPPSYHNSLLNTFDNYEEVCLRMNWLFPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3E8</accession>
    <name>A0A088S3E8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_355450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703476.1">
        <property type="nucleotide sequence ID" value="XM_010705174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3E8"/>
    <dbReference type="GeneID" id="22579573"/>
    <dbReference type="KEGG" id="lpan:LPMP_355450"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350063400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_355450"/>
    <dbReference type="eggNOG" id="ENOG502RY6U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272661at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1070" mass="113500" checksum="A0CAE2779AAD31DB" modified="2014-11-26" version="1">MSTAARTHLLPSGTEVDVENCFPVDDAPARSADCISWGPHNVLQVCTRWTVSMYLANLLTPAFQRSVRQHPLTHRSDGESVEVVVGAKWSTALLPEVYYPATARLCVQTTSNLMVYLVSRHGANRVMVSHGIGIACARGGLTRLPAHGDSSVAEASRSERPLSRSPAVEQPFIGELNAGAAETSVNPVSKPKAKNLSNAARRKRRRQGSSSSSASNSRASSSKNSIASDPSSSSGSQPLASHFAPRFSASTASAGKGKNSHESAMSTLVGARKADHPATATDTTEAYNASTENDDIGAVVDYMWLDQDDLLVLTTKGLHLVALSGNLSDMGGPVTLSLPPPLYRWGCEDEVAQLGFRGPTPLCMATLFTDGLAATTATPAALARLRRIVVIASPYMLRVIHVARTSPANSAAVVHLAYTVEVSSLTSVPTSVCAVAVRRPGCTVAQAEQPPPGSEVDVVVFVSAPGVVLRGRFALGALSSFSDSVLPSTCRCAVFQTEVHYGPDVLTGEVCLRRLMVVPFATDSRDAVVGLGDEGAHINSPNTGLGNAAVVVLGIGEKSVHEFLLCGSSSIALLQCPLLAGCSEMLLRRCAGIAGVALHPSGTLAVAAVQTGQANHEPTHLWPVSVDTRGGWLRRLVELGGLVPDAVAGQLHEACAFRGGVASYGPSGSMVHSMLLQQTSTSFFLFEQLFPGSVVQSREIHRYAQAHQQARQLPPIETLHQYRLSMMPGSVQPSPTPSLADMPARRRYLGLRTQYGVDLFLRWPLPSPTVAGDAASGVSSIFASPPSMEAMQASWVWWRLLQHIWASCPWDRPVLSELVLSNAVRILAKRYRYANMTLEGSESLRDYAANATKLERCSTKPDEFDVDGAIAFMEAYIKAQKIALHKNNGNTQTAPSSSLRLITAADCAEPAAPGGGNERLPRKAAADPPQPAAQVHWCVSPSWLSSLQAFLEATAYSHRRSTDASSAGSNTFGTSSPHLFPCSLCDRPACAPFLLSLSSTSTHVPANDNTAVECDASGTVPASHTTLFSGTTFSPLSFFSEDYVLTRCLACGLSDFADGPRCRVCGGLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3R9</accession>
    <name>A0A088S3R9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquitin-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_350560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702995.1">
        <property type="nucleotide sequence ID" value="XM_010704693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3R9"/>
    <dbReference type="GeneID" id="22579085"/>
    <dbReference type="KEGG" id="lpan:LPMP_350560"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350010700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_350560"/>
    <dbReference type="eggNOG" id="KOG0010">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267397at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000109">
        <property type="entry name" value="Ubiquitin-like protein DSK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000402">
        <property type="entry name" value="Ubiquitin-like protein DSK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015496">
        <property type="entry name" value="Ubiquilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677:SF3">
        <property type="entry name" value="FI07626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677">
        <property type="entry name" value="UBIQUILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="276"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO02195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="317" mass="33434" checksum="4D718AEB0F249D86" modified="2014-11-26" version="1">MTVTIKLANGNQHTVEVADFNITVAEFKNQIAETLAIPAEEQRIILRGKVLKDEGVLSAIGMEDGNVIHVVRSKKSVATAPATNVSSTPGTSDTVTSLNTQSPATVATQPALPQATANPYAALMSNFGAPQTQQPGFGAAGFPASGNPFANMGMGMGMAGGLGEAGSPTPQQAIELMQNPMMQQMMQQALNNPQFMQYIIQNSPQLAGLPQDQQQAVMEMMRNPYMMQQAMAMMSSLGGTGGMPPATLQAAPTPAVGTGFNSAMFAPPVPQGNPREVYREQLQLLRDMGFPNEEANIAALQQAQGNVQFALERLLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3S2</accession>
    <name>A0A088S3S2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 3 subunit 8, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_357190</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703646.1">
        <property type="nucleotide sequence ID" value="XM_010705344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3S2"/>
    <dbReference type="GeneID" id="22579747"/>
    <dbReference type="KEGG" id="lpan:LPMP_357190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350081600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_357190"/>
    <dbReference type="eggNOG" id="KOG1076">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="29647at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027516">
        <property type="entry name" value="EIF3C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008905">
        <property type="entry name" value="EIF3C_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITATION FACTOR 3, SUBUNIT 8 EIF3S8 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05470">
        <property type="entry name" value="eIF-3c_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Eukaryotic translation initiation factor 3 subunit C N-terminal" evidence="5">
        <location>
            <begin position="266"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="699"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="700"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO02846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="731" mass="81905" checksum="8619026595A13D8C" modified="2014-11-26" version="1">MNFFAISSSDSDSESEKSLLREEVPETQINPFWFEWTDEEELEERQEVIPKKEKAANSIQALCDTFDYNAGNQSWHEALETFKHMRDEVHNFVRKYKVAPQALQNCLQDMPNLAEYLEGKGREDFANRLEFKSLKDLVALVEETEKLYKKELEELAKGPENEDGVQDEDEDAGAELTESEYAQILEDISGSREVNLVGKIEKVIRACGRKGYTNLEISAMGIAVSTVLRRDSRKLLVSSDTWERAFKWGAKFFSRMIAATNVRFVEDSSSVSARNIVVPGGIHGFLTYLHTELVNKSKFEEVASQEYLKIIAFENDLAVLADRALGYYQVRKRTEPLKACIAILFDILGQRRQEAHQLFYNSLSSTDTLTIISESVFDTVRALHKLSLQVKPSAALSVSGVCHVAYQYGLCGLYREGRDYLLRTGVANSITVADAPLAILLNRAIAQLGLAAFIAGDIPTAHQLLRTIWSLRSNQVLIGQSPPPKSVLDDEHAEMEYRHLLLPPHMYMPIAQLELASVLSGLIMGVKMEAQNPYERNHMERYVYNTVTRTPDLMGKPFSFKEQVAVAYEHLKAGNYISAKEQVEAMTTFDTLPSGKEARRLYLQTLKEVALLVFCYSNRTSFSTMSVANLAIKFDMEESDVRRSVNEMLSENTTLSAYWDRDDAYLYLDRNNATRLQHLVKGTSESISILAKHCESRLRAGGGRGRGRSGAAGGRGGAGGRGAGGRGRGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S4A8</accession>
    <name>A0A088S4A8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tubulin binding cofactor C-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_353230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TBCC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703260.1">
        <property type="nucleotide sequence ID" value="XM_010704958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S4A8"/>
    <dbReference type="GeneID" id="22579352"/>
    <dbReference type="KEGG" id="lpan:LPMP_353230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350040000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_353230"/>
    <dbReference type="eggNOG" id="KOG2512">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="194775at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006599">
        <property type="entry name" value="CARP_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027684">
        <property type="entry name" value="TBCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012945">
        <property type="entry name" value="Tubulin-bd_cofactor_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15139">
        <property type="entry name" value="TUBULIN FOLDING COFACTOR C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15139:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07986">
        <property type="entry name" value="TBCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00673">
        <property type="entry name" value="CARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="4">
        <location>
            <begin position="130"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO02460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="335" mass="37167" checksum="2B9C14CA0C2699F3" modified="2014-11-26" version="1">MEEKFLQLRQGREEQRRQRSKETAVITVQRQQYESEAELLEAQVTQLLQEGNVTESQQRLDALRTLVQDTANSISLTAHEMAKANMILARLQQLVDEKSSSVAPKKFKFSSRAKAKPTPDAESTIRSLCPTGTSGTNEPTAMAAVTVAGTVNSTNGFGNVYGPSADTDLFINHSKGVFIRDCMNCTIYCLPIAGSVFLSACINCRVYVACHQLRLKGCMNLDLYAWCASTPIIETCDAMRFGPYQCWAGLLSSCTEDGKAYPTHMEWVRRVGEIEDTARTERNYIKVDDFQWVKKSPSPHWRVLTREEERVSTAVFGPATLPSSSSAHPTAAAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S4Y2</accession>
    <name>A0A088S4Y2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-2-hydroxyglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="7">1.1.99.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_355590</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2</text>
            <dbReference type="Rhea" id="RHEA:21252"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:16782"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.1.99.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the L2HGDH family.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.2" evidence="7"/>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703490.1">
        <property type="nucleotide sequence ID" value="XM_010705188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S4Y2"/>
    <dbReference type="GeneID" id="22579587"/>
    <dbReference type="KEGG" id="lpan:LPMP_355590"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350064600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_355590"/>
    <dbReference type="eggNOG" id="KOG2665">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047545">
        <property type="term" value="F:(S)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104:SF3">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="9">
        <location>
            <begin position="58"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIO02690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="522" mass="57002" checksum="28DA61D946390D71" modified="2014-11-26" version="1">MAPVLGKLCSGICQVAVACGLSGAVYYRRKYRSMATDDASTVHSLVTFSKDDRRDMYDVAIVGGGIVGVATAREIRKKYPSKRVVLIEREADVAQHQSGHNSGCIHAGMFYPPGSAMARLCPRGHGLIIDYCKKNKLPYELCGKMIVATEDSQRPIVQRLYDWGTANGVKGLEILEGEEAIKKKEPLVTGVSALWSPASGIVDFSEVTRCMLREMTAHADNNFAVQFQFDAQDFVGVSVTKSPVAGTEELVLIRGREKHHLGPEKTILAKNVITCCGLDSDIVAKHSGGIVEWVGKRLLQTYSFRGRYYQLTPERGDLVRMHVYPCPDNRRGLSVGVHFTPTVDVRRGRQVIVGPGSALALDRYGYTPYTIDLEYCFNCAFSKGGWVSLTSNFGVICQTYYMDLSKRKFLSEAQKLIPSIEAKDIVDSFCGVMGVGVAEDGTLSMDLAMEFARPRVTVQATMDKNKVLEPFKGAPSAAKAIEATGSAKPLILNVRNAPSPAATASMAIAEDIVQAATSRFQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S742</accession>
    <name>A0A088S742_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Proteasome maturation factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_190390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698034.1">
        <property type="nucleotide sequence ID" value="XM_010699732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S742"/>
    <dbReference type="GeneID" id="22574093"/>
    <dbReference type="KEGG" id="lpan:LPMP_190390"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190012100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_190390"/>
    <dbReference type="eggNOG" id="ENOG502S4ZS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276304at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0647">Proteasome</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="124" mass="13843" checksum="FE12B1BF2D0584A2" modified="2014-11-26" version="1">MSSEIGLPRPQAREERLMHPVEFIQRTAPRQEEVLRMNNIRTTHGLGAATEVALTEVTLLGSRRLGAMASSNTLYNAYRGNFTELTPCDVYGLPENDPNVQPAPRAFVEKQFHGHELTLKTLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S7E8</accession>
    <name>A0A088S7E8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_200090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698208.1">
        <property type="nucleotide sequence ID" value="XM_010699906.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22574216"/>
    <dbReference type="KEGG" id="lpan:LPMP_200090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200006100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_200090"/>
    <dbReference type="eggNOG" id="ENOG502SGJQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273731at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="781"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="30"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="139"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="430"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="539"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="620"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="723"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1048"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1187"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="781"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1322" mass="146790" checksum="71803C6926755C4C" modified="2014-11-26" version="1">MNTATSAARALSSDLLSRLQHDYPTVYESLHVYKKAVRHLKDKYEAKETELRRCISVGEELLGQMDVLKQRCEVLAQERDKAIATLGLAAASTVEHTHPTGATASSSSSWAEEKRTLLRSHEVECERYRTGMQKVLQGTAAAQAQKRELELALERTTAQLRETEKQLRTAQDTAVDCEARCATQHEKEIERHRAALARQLAEVRQQAEVDRETVLAEAMVELERLQRALVRTQKELVELQQASGDAQALQAELASTAAAEQASLQRQIRTLEEANHDLLQRLQRREAETQLLRAESSASARRGDSQRSPASANRGAGVCDSALANSLVDPRRESMNNVADVAGLAAVQVRLREENARLRQKLQEVARRGQDEVDEEHAARLSLQQHLHTVEAQSHILRTEVVGRIQQELQQARDQVEVSQAHGATVQRAAVELEVQAAALQEEKATLTDALRAEKETTERLWQELKAAQERQDALNQELQGASVAAQEKDQLVAQLQREKSQLLTALRTFQAQAADIETALTTVTAEQSESTAAHEATVSRLQDRCVLLAHEAEELRTERAALQCRLGDAEEAVDALKDAQRVSQALVREAQRGAKAAEDRASFAANQLTLQRQTSAARLAEVQQHLERAHTQQRDLSRRMEECQQELSRKEEALRKRAEAQEVLVAEIEQLRADQANRDESLRERWRQQYAQSSLERERLIAIKEAHIADLQRQQQELQMSLAENEDCVAQLQGQRQQLQAALSDSLATAAGHKGRIQALEEELACTREAHRTAQRELQRVAGERERDSSATPALQPSGECDASAAARLAQMQVQLAECEAALCAAERSRQLVQCTVLGCLIPIDTSGAVKADTDKVWDTLLDLLSHGEQELRSRSTSAMQAQAWQVSQHEVSPVSDDKQTADAASLPIDAIQRAAAGVLRATNNLLRYLHDADLHRWSCVINKVMAAFVVTEAASEETASAGAGPPAIEGPAAASSEKLCADLASALRMWAQALRQTQDHLAEHVAQVAKAAHLASTETAQRAQLKQLTLATRIAEEQCGALQVALEEMTAKYSEVVKRAEAQESRAEALRHDVAARDICVREMEHRLDVCQAEVQAERAEWVSKWQEAQRHREAEKREAEAEHARLRAQVMATEEAAHHSTQRAVQESAGAQQQLHTQLQALLESSSAMEVQLRQQVTQLSRGKEDSERGLRRLKSVVAQLEERLSSTEETLRSRETELKIAVASMQELKQAQLQRCADGAAANAFEQRTLTEQVASLQAQLLSSQRDHEMQEALHAAERAEMAALRKVNTSLETRLAEVEGDRAPLREQLHSLLSFTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S7Y6</accession>
    <name>A0A088S7Y6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent protein deacylase</fullName>
            <ecNumber evidence="3">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Regulatory protein SIR2 homolog 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_201820</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>N(6)-glutaryl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-glutaryl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:47664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:11875"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:87828"/>
            <dbReference type="ChEBI" id="CHEBI:87829"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>N(6)-malonyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-malonyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:47672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:11878"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:87831"/>
            <dbReference type="ChEBI" id="CHEBI:87833"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>N(6)-succinyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-succinyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:47668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:11877"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:87830"/>
            <dbReference type="ChEBI" id="CHEBI:87832"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">In contrast to class I sirtuins, class III sirtuins have only weak deacetylase activity. Difference in substrate specificity is probably due to a larger hydrophobic pocket with 2 residues (Tyr-93 and Arg-96) that bind to malonylated and succinylated substrates and define the specificity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sirtuin family. Class III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3 4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698383.1">
        <property type="nucleotide sequence ID" value="XM_010700081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S7Y6"/>
    <dbReference type="SMR" id="A0A088S7Y6"/>
    <dbReference type="GeneID" id="22574391"/>
    <dbReference type="KEGG" id="lpan:LPMP_201820"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200023600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201820"/>
    <dbReference type="eggNOG" id="KOG2684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="424302at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061697">
        <property type="term" value="F:protein-glutaryllysine deglutarylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036054">
        <property type="term" value="F:protein-malonyllysine demalonylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036055">
        <property type="term" value="F:protein-succinyllysine desuccinylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01412">
        <property type="entry name" value="SIRT5_Af1_CobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01121">
        <property type="entry name" value="Sirtuin_ClassIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027546">
        <property type="entry name" value="Sirtuin_class_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001755">
        <property type="entry name" value="PRK00481.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF4">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 3" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="5">
        <location>
            <begin position="23"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="132"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="218"/>
            <end position="220"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="244"/>
            <end position="246"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN97676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="280" mass="31003" checksum="AC55AC6444813DA2" modified="2014-11-26" version="1">MGRERENSTVVIICSHLPLLSLPPKQSSGGQPQEHALMKTCRCITVLTGAGISAESGIPTFRDGDGLWCNHRVEDVASPDAFLANPALVQHFYNERRRNLLLSSVRPNKAHMALARLENELRRKTKVVVVTQNVDDLHERAGSTHVLHMHGELLKVRCTVTGKVFVWTKDIVRDADCCPDCGLLGTLRPHIVWFGEMPLYMDKIESVLSETDIFVSIGTSGDVYPAAGFVQRAQFYGSTTLELNLQEGSNNSFFQESIYGKASVIVPAWVDRVLKASSGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SAN9</accession>
    <name>A0A088SAN9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_240560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699398.1">
        <property type="nucleotide sequence ID" value="XM_010701096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SAN9"/>
    <dbReference type="GeneID" id="22575465"/>
    <dbReference type="KEGG" id="lpan:LPMP_240560"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240011500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_240560"/>
    <dbReference type="eggNOG" id="ENOG502SH9T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="259356at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="707"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="801"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="857" mass="96169" checksum="1DBB1BCA3050870A" modified="2014-11-26" version="1">MSATTAQVYGKLVPGQLLQLTGNSKPTIVTPLCNEVGLNLLIRTYKGEGYLPYFTHAAKAARATLVDELRDAGVEVPEGAEASHLEDVCGVRCHDEASCRHVIHEDITETVYEEDKNDARVIVACDPIQTKLRDDCMECFPRLDKVRKQEELVVRVHLFYPSSMPCMSIQDRRARLVTHKHFVRKNARTSQGYHTFHYAKRDDYSAPTPDYESMFPYTTKAEESSGFTMGCKCTAITVETVFVRDPARQQRPLYAEDAEQARVYFSYVRPSAFVTDDELTDHFPLESLDAATMPAFADDREVEKYNVLVRLYLLAHDQEWTTTRSYGCPHPLGGPVDLPVLYHSSATEVVVPDRHSRNSPVLLQQYLLPDVESQITRFCFRRVVSEVLRQRVLAAAADTPERYVAIVCYMPHGDRVPVFTDEQVRVMARLYPHLGIRSPANRREWACLSRTLYQHGISLFDILAAVGCPLRDAQGAVIDTGAYVPYTADMADDYFLVIANRPLRDYICFTNQRWVHEQLRFPDYRPSIGARAFAAWVRYWNTMVQLKQELEEQASVDTVSAHLGLGLPGSTLVQRAACLVNGRVTDAEGGLIFPELGGRRFRDRVYASALLPGTPMLYSFWIDRKLCFSCVCAPIRFIRGLPSDETVRELPGKNVIQVVDAPPSRGGGAQWGGRGDRQGASVAIHAGSMEVPRARHMRPPFSLPMRGIHAHGDPMASVHSLGSGGGPGWKPALQAPDGPKKQHPPPHMEVYSAPMHHHRHRGDGPPGVWRQPLWHHQHQQGPTQGKGGYKTIANPHGSQQQHREREQESSTRSRAVGSAPHQHYRSHNDPSMYRTETLAYDQYSDNRGGPKRGAASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SCA3</accession>
    <name>A0A088SCA3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_262180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eL38 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700038.1">
        <property type="nucleotide sequence ID" value="XM_010701736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SCA3"/>
    <dbReference type="GeneID" id="22576121"/>
    <dbReference type="KEGG" id="lpan:LPMP_262180"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260026600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_262180"/>
    <dbReference type="eggNOG" id="KOG3499">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268647at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022618">
        <property type="term" value="P:protein-RNA complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.90:FF:000002">
        <property type="entry name" value="60S ribosomal proteins L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002675">
        <property type="entry name" value="Ribosomal_eL38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038464">
        <property type="entry name" value="Ribosomal_eL38_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01781">
        <property type="entry name" value="Ribosomal_L38e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN99331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="83" mass="9473" checksum="36429C2F283B7A8A" modified="2014-11-26" version="1">MPREIKTLKEFLAVCSRKDARCVKVKRNPSATKFKVRCSRYLYTLVVNDKKKADKIERSIHPSVKKIAVTARSHAKTNAGTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SFL8</accession>
    <name>A0A088SFL8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal P protein AGP2beta-1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_303700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701392.1">
        <property type="nucleotide sequence ID" value="XM_010703090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SFL8"/>
    <dbReference type="GeneID" id="22577423"/>
    <dbReference type="KEGG" id="lpan:LPMP_303700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300042100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_303700"/>
    <dbReference type="eggNOG" id="ENOG502S1ZD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270566at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="222" mass="24468" checksum="262503B0CFA9B023" modified="2014-11-26" version="1">MALQENKDSYNIKALSLSEFVLQCSDCHRLCLEKTARVLENRSRAPRGWEGLFSSVAEQRRFEDLDLCESRCHNVQAVCPSNDKVREYEQALAAASLKPKNITPPNPSLLQAASRCQHAVEVFSNVLFALAHKPSKVSFPIKDPAKGEGKGSEPHDGAPTETHRKVLAGATNMNSEILRRGRKGHQDQLIPREEDIASSTDSDWATHTPTSAPGLSGTTPKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SGF3</accession>
    <name>A0A088SGF3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Qa-SNARE protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_320080</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO00897.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701697.1">
        <property type="nucleotide sequence ID" value="XM_010703395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SGF3"/>
    <dbReference type="GeneID" id="22577749"/>
    <dbReference type="KEGG" id="lpan:LPMP_320080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320005700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_320080"/>
    <dbReference type="eggNOG" id="KOG0812">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="421009at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15844">
        <property type="entry name" value="SNARE_syntaxin5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000034">
        <property type="entry name" value="Syntaxin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF3">
        <property type="entry name" value="SYNTAXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO00897.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="307" mass="35075" checksum="BD35A9264749A0F5" modified="2026-01-28" version="2">MVVERDRSNELYDLFSRQRQSRLPQSTGVVVCTGLHSSSDVQTFNRFAKEFSNNIATVSEYIMRLAQLANRQSVFDDQTAEVSELTQMVKSSLQRLHSDVGTLEELKRRSVESQKGVFKAKGDSRGIFGGSINHLRTSEKHSDTVVETLRSRLARTGQQFRTTLQHQSKSLKDKANRRHMFTTADRPQSFESALFQDQEQRQQQQLLLSGTGNTQYYQQRADAVLEIEAAVQEVGELFNDFTRLVQEQEEVVLRIDTDVDSAVRHVNAGSHELMQYLTNLSSNRGLILKVFAMLFFFLMLFGILVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SH89</accession>
    <name>A0A088SH89_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_322720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701957.1">
        <property type="nucleotide sequence ID" value="XM_010703655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SH89"/>
    <dbReference type="GeneID" id="22578013"/>
    <dbReference type="KEGG" id="lpan:LPMP_322720"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320033400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_322720"/>
    <dbReference type="eggNOG" id="ENOG502QTUC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25131at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039328">
        <property type="entry name" value="WDR89"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22889">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22889:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="321"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="345"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO01157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="366" mass="39529" checksum="0664EF2158C0D531" modified="2014-11-26" version="1">MNLLHVVQTSYEPSTYITEGCLCNGSSSLALSISTQNIRLYDAQMATHLADIKDHTQPIQDLVTTPAQPSMLYSCQRDCGVMVSDLRQVRAVHFLSDMCHSGAVCSSIGVTPSAPLLAIAADRDIHLVDTRTWCSVKCLEQLHVDEVSRLRFLNDSILCSAGEDQMINFLSVEERVMDDDVLLQAVSCGEVVTKMNCFSELGVTAIVGSCENGYLFPYDLEQRETRYSRPSFETYLVDWCLVSGQLHLVSGVRDDNGDAGPLQVLNGVTGQTQVLPKVHKELSRVAIGLGDRLITGGEDGVLAYWRHGDLQPSEIATVVGPSARHTGGGKAAASSRELEGHVRGGHGGGGRRGSGGPRRGGRGRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SHJ5</accession>
    <name>A0A088SHJ5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Centrosomal protein CEP104 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_330090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702102.1">
        <property type="nucleotide sequence ID" value="XM_010703800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SHJ5"/>
    <dbReference type="GeneID" id="22578162"/>
    <dbReference type="KEGG" id="lpan:LPMP_330090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330005600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_330090"/>
    <dbReference type="eggNOG" id="KOG4825">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="66599at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052607">
        <property type="entry name" value="CEP104-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048739">
        <property type="entry name" value="CEP104_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13371">
        <property type="entry name" value="GLYCINE-, GLUTAMATE-, THIENYLCYCLOHEXYLPIPERIDINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13371:SF3">
        <property type="entry name" value="TOG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21040">
        <property type="entry name" value="CEP104-like_TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21038">
        <property type="entry name" value="CEP104_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomal protein CEP104 N-terminal" evidence="2">
        <location>
            <begin position="40"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="688" mass="75773" checksum="F81F65BF1DE42FE0" modified="2014-11-26" version="1">MSVVLPYDVLFCTSEDPHHPVSELGGCTGEVKPGLRIPTGWQSARHGKTPQTLVIRFHGNVWLQQLRILSHEAKIATKVEVRVAKLTEDDDWDNPPSFRNVRFVKLGSVDFNSNEQSHFRSKERKTVHLKTEAYFLKLLFDRPFINPHNTGHQVGIYSLECSGYLIEPIPFHADRPPEVETPSQRRSSALSPTKCAGAKQQTSGAPPVLVPLDDQRVRRASILNATGDTLIPLVSLTPSPTTHLSSSGGAFRSVRILEFEDFFLRRSEELVSLKTEAVALEDYHVAAECRDKLALLNERSKDIYELEQDKVQAIIDEEFDVAQQVKARMNALVEQLFAQTSLPFPAAASPPPSERCDDPAHGVASHSRHISSIPSTRVPMADAPHHSEVLRDVELTESDTIEAIEETGHLIDVSTLESQEKAVAHAILSCAGSKDLSSVALANPDFDIEFLTAAVGRFTVACLFSRRFQLREAALNVLTEKMDMLQSPAPVVQEALLRFLDFNGYGLQDTIPNVVFAACAFVRGCLADTSKCISAALAPLVALLPRLVTRCSDSIQRIRDEAHTTLALYVKNSSIPHSSILSVALMEPTDKEGRSLPLSNAKAQLARLSLFQLLLENGRLHLDSGGINPAQVLHKLLLPTVNHPYSEVRDVAALILGKLVAGRQLILRDKDLAKVTHASIRESIASKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SL38</accession>
    <name>A0A088SL38_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L10a, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_353870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703322.1">
        <property type="nucleotide sequence ID" value="XM_010705020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SL38"/>
    <dbReference type="GeneID" id="22579415"/>
    <dbReference type="KEGG" id="lpan:LPMP_353870"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350046700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_353870"/>
    <dbReference type="eggNOG" id="KOG1570">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275071at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.190.20:FF:000006">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.790:FF:000002">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_uL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO02522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="214" mass="24597" checksum="F90196C335F2787D" modified="2014-11-26" version="1">MSKISPQALSEAIQAVLKVDKERKFKESIDLQVNLKNYDPQKDKRFSGSLKLPNVCRPRMTVCLLCDLVHEDIAKKEGVPTMNQEELKKLNKNKKLVKKMCNQYDAFLCSESIIKTVPRLVGPHMHRMGKFPTVCSPSESLTEKVVELRSTVKFQLKKVLCLGTCIGHIEMNEEQLRQNVMMAINFLVSLLKKNWQNLKSAYIKSTMGRPQRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4K5</accession>
    <name>A0AC62A4K5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Heat shock protein 83</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">HSP83</name>
        <name evidence="1" type="ORF">LPMP_3320120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="XUY36720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="705" mass="80907" checksum="AF8312B058703C87" modified="2026-01-28" version="1">MTETFAFQAEINQLMSLIINTFYSNKEIFLRELISNASDACDKIRYQSLTDPSVLGEETHLRVRVVPDKANKTLTVEDNGIGMTKADLVNNLGTIARSGTKAFMEALEAGGDMSMIGQFGVGFYSAYLVADRVTVVSKNNSDEAYVWESSAGGTFTITSVQESDMKRGTRITLHLKEDQQEYLEERRVKDLIKKHSEFIGYDIELMVEKTAEKEVTDEDEEEDESKKKSCGDEGEPKVEEVTEGGEDKKKKTKKVKEVTKTYEVQNKHKPLWTRDPKDVTKEEYAAFYKAISNDWEDPAATKHFSVEGQLEFRAIMFVPKRAPFDMFEPNKKRNNIKLYVRRVFIMDNCEDLCPDWLGFVKGVVDSEDLPLNISRENLQQNKILKVIRKNIVKKCLELFEEMAENKEDYKQFYEQFGKNIKLGIHEDTANRKKLMELLRFYSTESGEEMTTLKDYVTRMKPEQKSIYYITGDSKKKLESSPFIEKARRCGLEVLFMTEPIDEYVMQQVKDFEDKKFACLTKEGVHFEESEEEKKQREEKKAACEKLCKTMKEVLGDKVEKVTVSERLSTSPCILVTSEFGWSAHMEQIMRNQALRDSSMAQYMMSKKTMEVNPDHPIIKELRRRVEADENDKAVKDLVFLLFDTSLLTSGFQLDDPTGYAERINRMIKLGLSLDEEEEEEVAEAAPAEAAPAEVTAGTSSMEQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5A3</accession>
    <name>A0AC62A5A3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1320030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="XUY36974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="776" mass="83995" checksum="8955A0636EDB567B" modified="2026-01-28" version="1">MKKLFGSRNSANTSSPTPRTTAAAVDSNKRDELYEAAVGDGKGGVLNKDGDMSGSTMTDAASIYTGGRQGLDPAKRHGSCYIGGTNGRCGTCGLSKIACNCQTCHCCGRFLMSPSSRRHCRQCWRATCADCSTSVRTNDFMGGRVTLTCNFCAVPKALCFVTQMRYSSYDAVGAVDLTMGNGAVRNDDVGAKPPQANMRAAMEPCTFRWGVYALGCAIESPRRCINPSCPAPLSYAEVCVRCKMPTVVMTFHDQRHIVMQNTSVEGKRPDANDSSVRMVEAVEDAVRSAYDNMATSRTSADEEEIFASALPSGMETQLFSSALSGPAVRKVLLSLVACYIAGESSGTPCVSLALTDLPLYGRLLRPTNVTELFTVFDGPGRTRFISFSSGTTRRPALHQVLGTRMVPRELWSNATMKKENVVGKVVGGKEAARKGGLNTNVATWTMRAGLLAYMAEDNIMDRVQSLALRIVKSSSEVVICGHGVGGAAAAWLTTCLLLENTPETRDRLMCVTFGAPLIASQSLSEVLVKNDLAKNFHHFVYGSDMVPRLCYVDSLLLSGNTAGCTLSVGLEEEAASGRRVQECTAAWVALHEEPHNPADIAQAMAEIGDDNLSLTNFSSSAQQAPIEGPIDAAPPDKKELSKQPTQPADTAARTAATAMGDLFLQSREPFGNTSVRTVHKGDEDAQGAVVAGHFNVRDADFKYFSSQQHRDRQVMDPFGFYHFLWHPRKKYMCTDDPKTIIAMLSDRTELRIQLSDHLLSSYNKGMLEYMYSACPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5J5</accession>
    <name>A0AC62A5J5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histone H3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1620130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="XUY37024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="66" mass="7238" checksum="D87F239EB5F19D1A" modified="2026-01-28" version="1">MPCARCRACRRRGGPALPEQRDPGDPGGVRCVADGCHEPGQHPREACVTVRPKDVQLAVRLRGERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5K3</accession>
    <name>A0AC62A5K3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Elongation factor 1-alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1720020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="XUY37092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="449" mass="49058" checksum="C7CA18E3C4A6A3F4" modified="2026-01-28" version="1">MGKDKVHMNLVVVGHVDAGKSTATGHLIYKCGGIDKRTIEKFEKEAAEMGKASFKYAWVLDKLKAERERGITIDIALWKFESPKSVFTIIDAPGHRDFIKNMITGTSQADAAILMIDSTQGGFEAGISKDGQTREHALLAFTLGVKQMVVCCNKMDDKTVQYSQSRYEEISKEVGAYLKRVGYNPEKVRFIPISGWQGDNMIDKSESMAWYKGPTLLDALDMLEAPVRPVDKPLRLPLQDVYKIGGIGTVPVGRVETGIMKPGDVVTFAPANVTTEVKSIEMHHEQLAEAVPGDNVGFNVKNVSVKDIRRGNVCGNSKNDPPKEAADFTAQVIVLNHPGQISNGYAPVLDCHTSHIACRFADIESKIDRRSGKELEKNPKAIKSGDAAIVKMVPQKPMCVEVFNDYPPLGRFAVRDMRQTVAVGIIKAVSKKDGSAGKVTKAAAKAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5U1</accession>
    <name>A0AC62A5U1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP dependent DEAD-box helicase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">RH</name>
        <name evidence="1" type="ORF">LPMP_2020720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="775" mass="86694" checksum="325F2BD5F1B22553" modified="2026-01-28" version="1">MPRLAATRNWLLRRYTASCTHCLSAFSYLVITTRSVVQSNMMGGPRSLLNRFETRELVTRLRRNRNGNYYRFRQKLWPSQEALEKAVTTMTYSPVGRQPLALLPQREAPRQVFACEGRGGSMLLEAVETEERGASALQSSPASAAVPLLRSQSESGVDSDSLDFMEEVLRADQSVSSKIMTEADVRGTVLGSASTRARQILAGDLTCNPVTASHSTSIFLRRPAESTDAAGISWSALGLDAPISSAAEQLYGPVPTRLQTRLLSALLHEDHDDVLFNGVTGSGKTSALVLALLQGIRSEAAGMNVLVATNTMNAMRLHDTVKALCRRAGGGVVVDRPADDYSWLFLGTYREDHESYYRQLRRGLRCSTGPARLVITTADVMCQLLFEKKMEFEDFGYLRRVYVDDVGAQVPMLPESVPVEVVRERLRNPLAAELLLGTLHQLPGPHIRSVLQLALVSADVDGKLKDHLQGLCMKPVAQTTVLSAVRVPSAVHCLFSFFLGHKEDRFTYLVRVLGNARETIPGRAVLFVPDAEDVLSARRRLRGLGVDARLFSEVYGGNEFKADWKFLLLRESEAFGVDLPLVSHVFINFAPTSWQSFLHMCGRTGRMGNVGWVYVVSDKQEAKRVRQVAEALSVDFCNHVIHEDLQQVLPAHVERFTKQPELYGLDPQFAVRQHYTMQAESPDMAYRKREFFSKPAIKQFQMEDHTSIPLKQRRFDHARQLSQDVARNPSLVLDMQKQGLLDAQLKPTKKLKRCTDVTTNRHAPDPFQKGQRRCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5V3</accession>
    <name>A0AC62A5V3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amastin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2020350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="218" mass="24213" checksum="9EFD9E76712432A0" modified="2026-01-28" version="1">MEWNIPILLYAIVQVIAFVLVLFGTPIDMYRFRPRYIRPNATVTTLWGVKKGAFNSTNLMTSDYLWRRCTGRRDRFRLAQAFAVISIFVYGAAAALGFIMLYCCSFFRMVCLALNIVGAVTLCIVWAAVAVTYHTYEGPDCWQESVFSTYGAGFVLLLLAWLLDLFNIVVLLLPISIAAGGAGGSSSKDSKKQDESSNDHSRESSMEGSRQNDLSEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A674</accession>
    <name>A0AC62A674_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amastin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0820280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="XUY37308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="325" mass="36504" checksum="EC2C0481CE3A6E52" modified="2026-01-28" version="1">MVCNVAAVLYAVLQFIAFLAVLLGTPIDMFRMRGESIFSNTPCETLWGSKQMCYSAVYNATVADFLQKCPHRFLIFRFAEVFVLISILVYGLAAFFGFILLCCCSCLRWVCLTLNITGIPTLGVVWVSMVLVYYQDDDGCEKKMKNSVFGLGFMLLLVAWCLDVINIIFLVIPWPARDRGESRDRSESRDPSKSRDPNESRDPNEGRDPNEGRDPNEGRDPNEGRDPNEGRDPNEGRDPNEGRDPNEGRDPNEGRDPNEGRDPNEGRDPNEGRDPNEGRDPNEGRDPNEGRDPNEGRDPNEGRDPNEGRDPNEGRDPNEGGEPNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A691</accession>
    <name>A0AC62A691_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Receptor-type adenylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1720210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="XUY37111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0675">Receptor</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1316" mass="141975" checksum="0098EDF5C0602D8D" modified="2026-01-28" version="1">MHAGTPHPRRICGRGAGGVAGGLKRLHTYRRSPLLAAALLIVGALTLAVFTAPTAWAAGAGILSEEPVYLLNAMYSMTDYMASYAEALWLGIDAALYNAGYTAAGGRPIRIIDPDPDVNRADIVAVVTKALKDYPTLLGVIGPYSDTRLAALLSSPVIQSSGLMLLGPFTGSSAVRAWNENVYFMRAEPRAELLAIVKHVANTIRGRRTAFMYLTGVDFGEREYEDIVALMTPLGLEPPALYSAPHSMTDFAVDMTAFDAMANTYPHVIILWGMPGRQVAEFLRVALTDPRTSSAYIMTCFPLQKIAFQVYYDLAMAEKLTPVDGQLMSSATSFPLTQPNTTHIPAFRAEMGKYMEQTGRVDESLWADEAKAVREYGSGGHEPPSSDSAADVRRFFNEHPNAANLMLTGWIFGSVIMQTFAEEEWIVDRTAYQGYAFEQRRYIIGGDYVLGDYGAPCNPVAAFLGAVCYCNQGGRAAIVSKLDSATWNTIEESGFNYVQNYCYSTHTSLPRPLHFLTLVFTDDPTLAVAGLDLNVAISALVRYLKYTEHPVSVTTLNVQRTTAQALLDHQLLNYTADVVAGAITKGMRVDGYLVPAPVYPRPHLVEPMRNYVYLMPTLEQQMFLLYENLATLRRVTSIGSGVRVVLHGYADDEASSITAVLYKSAATFNYNNPSVVMVPSTKTVGSALVRRQINFVLAVTAADVADVVDFLIADKSAIVVMVFDDLALHYTALVTALSSTPASVQARVITFTNLPLWSDTSSSAHDAFPMLQVFHGALPDPSQHTPSFLRACVTALVPFKLMRTVKSMREATLADALYFNGITTRYGMAFGIFEWGCTTTASGDDCIYENYGAQSIVMLSVQRMLDPRVPPLTAPMTPSLVYRPRVASSALTPAERNGIIAGVVLLVVASIAAVGLLLYCCMGNRDNDAAPKDGDEPVTLVFTDIESSTALWAVLPQLMADAIVAHHRVIRQLIVKHGCYEVKTVGDSFMIACKSAHSAVRLACEIQTKLLGHDWGTVSIDAAYREFELARADADDDYVPPTARLSEEEYAAVWCGLRVRVGVHTGLCDIRYDEVTKGYDYYGDTPNMAARTEAIANGGQVVATETAWWALSNEERAGAAHTAMGRQGLRGVPFAVEMFQVDAVPGRRHAALRTEIEAILPDETATETASSAAGALLSSVGTMSGPAAGIALVLTSCFAPYPVAQRVRELQPLLSKWGVGAPPRSRAVSEEDYCQGLMNRLALRIATVSQARQRIGKGGAVVAGDMPDVDAGGALNPLVGGGGCGVGGAAPRPSGMTAPPRSGVPSAVRDLRMLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6C8</accession>
    <name>A0AC62A6C8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATG8/AUT7/APG8/PAZ2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ATG8B.2</name>
        <name evidence="1" type="ORF">LPMP_1920200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="XUY37141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="118" mass="12274" checksum="A4EBC961EE5BB0EB" modified="2026-01-28" version="1">MSAYQSSNTAEARRAECARLQAKYPGHVAMVVEAAKSSKAHLLALPRDATVAELEAAVRQALGISAAKVTLAVEGCTPAATAAVGDVADACKHADGFLYVSVRGEQAMGIFSLCFPFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6G5</accession>
    <name>A0AC62A6G5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycan beta 1,3 galactosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0220070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009371">
        <property type="protein sequence ID" value="XUY37392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="833" mass="92516" checksum="D258CEE13BD41F18" modified="2026-01-28" version="1">MSWMSSEMGTPGGSPTSAMPFSGPPLSCVTSLPQRCTGFFRYSATPNCTAPRSPKLKRGDAGGSRPPPQLWRLVERVRLGAARLWGRLLGMRERPMHLLMCVALCVILVVVIWWLSMWCRRRHPLSEEQLARLLGPLSKPWSVLVQHEGAVDRLSKVILVEEWLARCSSRGTPLTECNEPLLLSPHMLPSWTLHVVEKGCADCTDQQTYASAVEGVVLQARHAVFATSAAPLGRVGPMLLAMASVTDDVDVRAELPQWEWLRHVHGSGFPAVGGAAGVSAPPRAPYLAVMGIPSTDQRPRAALREAQRKTWLAYQEVARRDNHFTGALLALYVFAAAEPDPILDPSEDSAESLHSGTSAASPGRAGLRVLLPTTAEYKTATQALLARAMQADGVDGVAGEGFAQRRMELRRGWSTAAVDGSPCAEVASSWTAGGAKTSALSYLSGALSLPVTPAFTSPAEYICHASSALWQEALTHRNVLWIDMMTDRRPTTKKKLGEPTKWGLPVEVGMSQKLILWLAYAYHAFKDVPFIIKGDDDSYMKVPQFLSDVRYVMSGMQARPPPPPSRRGAASGQQNLTDTVGRLSAEELAKSASLAEDTECVYWGSLRHHLHTQFSAGMTFMLHRRVVQALLEPKVGTRRLDVLRLAADDFSAKRTLAYRRIMFHHEDILIGLQIYRALERVKALCSTGRLWYVKEWYARFHDMHVGRTHNVTWSTVVAHRCRPSDAYYLHFYFQEEHRIAAAAAASRFATEEEHEAAAVKRASQWLEGNLRDPHMMAMNWSGLPDVQWVQGTSRRPSFTLAEGDGVAVYDNRYEYWRHEATNIHDGYRSLPQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A721</accession>
    <name>A0AC62A721_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Beta-fructofuranosidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0420150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="XUY37431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="641" mass="72053" checksum="8AA66DE3E086144C" modified="2026-01-28" version="1">MTAALVRRRVILLLVAVAMIAAAAVAMDGVPYEPIYHIRPPKNWINDPNGPYRDPVTGKIHLYMQYNPNGPLWGDIAWYHVTSEDYVKWTRPESPVAMWADRWYDRWGVYSGTMMNNNYSEPVIVYTCTEPENIQRQCIANPPKSDLHGKRTLDTLVKSPLNAIMSEDMIPGLVALENFRDPTEWWLDPTHPNRWLIGFVARIKDSEGDNAHVILFSTEDPSFQSGYSFSHSLYTYKYDLDRMFECPDFFTLTQGGEHYLKLSTMPSHRDYFVYGAYQADPVTGKYIFVEDPERSFTFVDYGPLYASKTFYDPILNRRTMWGWTMDELSDTQVRANGWSGVQNMLRTVVYDTVEQKIKTQPVPETKGLRLHKLVDMKGIAVTQTPTQIVASNTNNTLYHEIIARFTLADPATFAADATYADDSEVPEVGVMVRANASLGQYTTVSVRMPTGGPSPSESTQQLETYPAIKVFSTPTAASCSAECNKMRLCESYTFRESDKNCTMYWKTNPMGTSADATSGTVREPLLYLGRTQSGTIGNTAPLHGRAPFATATPNGFELHIFVDDSVLEVFKDEGLETLTGRLYIDNGADTTGVAVYARNAGTVTVDIEVYTMDTIWKAPTPNAARNFTNSLYNLLDTLIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RH88</accession>
    <name>A0A088RH88_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ARP2/3 complex subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_020480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ARPC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009371">
        <property type="protein sequence ID" value="AIN95228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698193.1">
        <property type="nucleotide sequence ID" value="XM_010699891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RH88"/>
    <dbReference type="GeneID" id="22571858"/>
    <dbReference type="KEGG" id="lpan:LPMP_020480"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_020009900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_020480"/>
    <dbReference type="eggNOG" id="KOG1876">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="336240at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008384">
        <property type="entry name" value="ARPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629">
        <property type="entry name" value="ARP2/3 COMPLEX 20 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05856">
        <property type="entry name" value="ARPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN95228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="223" mass="24056" checksum="6FF448ADA236A65C" modified="2014-11-26" version="1">MAGEKQLYYDCVERTLLVALCLQSFASDVTEGCAVPEVELMSPYTATDASPFPFLVHPATADASLQSNKLQLQWSSGDECLVEGSFNSTRVSFWFAAAHQPDDVLSTQLLSEYLAFFCSHDAATGTLPVLRCAPVRQALMAKPAADAADQVIYDVSFLVLAAHVRQYGRHSLARFIMTFVKEAEAAVDMLKASLNSSGRAAAQSFFSLPVQANDDEDGEAGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHG0</accession>
    <name>A0A088RHG0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_040940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="AIN95417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703739.1">
        <property type="nucleotide sequence ID" value="XM_010705437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHG0"/>
    <dbReference type="GeneID" id="22572053"/>
    <dbReference type="KEGG" id="lpan:LPMP_040940"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040016600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_040940"/>
    <dbReference type="eggNOG" id="ENOG502RW79">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273342at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="665"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1150"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1249" mass="134091" checksum="E1A61DEFFDACED99" modified="2014-11-26" version="1">MPQRKNEAVAPVQQAQAPWDDGSLSDDGDGELCTVLEDAWTMQARNLGKSQPTAATSRSRLPVAVSPPSGQDHPHPCDNASADLCETRQTQELRDDFFALYTSQSAAESPNDRRGRGGMTGSAASLSAAAADSNEDGSSSCLSDQEDEGTDRDNAVSTDVEVRVSRTDDHHAQQSQYVPECADYLEEEDGIADSTESPLVSEQPEEGFKAETQQLPSHSGTMPAIEAPRHPECWPHPHPPPFSALPRPCQTRVTFHTQRYGAFIKAYLGLSDVEVEQAQRRGRGICMIGVRKAPPSSSHLVSSASYITPFTLTSSSSAAAVANSGAYQPVHHRHSHHGFGEPVKVQRTFLRHSVLAVEGDAVFSELIDRAEVLYATEQHRLDAAWKTYAHNAGAAGEDTAAAPGAPAQSPLYPQFRKLPRVVEPYLRPNARCIALHYGLPDQANSDSSPGSAGRGATTDMAAAKQEGGQEKERMPRMHHTHSGAGCLNPYPRASLMAVVCTTRLGEGEEIYVSLESYYRCLDEVSWYRRCYSELNKRYACPDGIGTPCTATAAEGDGGRTEATACHGDLMGNVYTGVKRFPEWPADLAYYHGVGRRHASSVAEGAFPFTLVALGPAPELGDNQKGVVASAWLPYGTCLLYCGPSVAARKVERLVSERALRGSSAVDPIAAQNQTPTEQEGDEEDISFASDDTYALGLGRHGVCFGQGLTRYINHRYNTSRFGNVELCSVILSVPSEFAGAHETAVGTPASTASATAGGTVGLRNAGEKLTLKSTGASATSSLITEEQRAQVARAATAKRPYRRRRAQRAKKETAASVAEANGAVVVPAPTVADGLAALYAKPRRRPPRRRAPCLFLEERSLFVTVPFFLATTDIPPGTPLLAWTYGEDYDAKLERHAVADGYVVPYADAVLLNRRLAATAAISASSPATDCRFQRYGGDYRFAVGVGDIVWRRRPVRLGVLPSSANCADGHDSADVSVPPPEEDLFVVVQTLRSSVERVLLRPLQRIPLTNPQLGRLLREQHLDNYVSPHTSSNARPGLRKGCRRVGCPPSANSKRQRAAAPAYDWAAHWAVFRLTDISALAPAPFTAASSNLTPHTLARYEEALRTCVVATIDSVGLLLMDIDYSAVHCTRDTSGEAADTVAAQLTARDLQGSTTRPSAGGRRSLNAKQRSSRGGEGETHRLILVNLDDLHHATSLVRMSPGRAAAVPALCNGLLWPLYCMSPRPLTAAAAALGASADVLRTRSGSCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHL3</accession>
    <name>A0A088RHL3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_050260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="AIN95467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703789.1">
        <property type="nucleotide sequence ID" value="XM_010705487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHL3"/>
    <dbReference type="GeneID" id="22572104"/>
    <dbReference type="KEGG" id="lpan:LPMP_050260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000024900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_050260"/>
    <dbReference type="eggNOG" id="ENOG502RZ70">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="245401at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN95467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="321" mass="35477" checksum="9C5BEC4AD3EF1BE8" modified="2014-11-26" version="1">MAEADDEEDVRLMSREERIASYRELVEGLDDILASHDADGDHDGEDAMQMAALVEEVEVQLRTLAQLLNDEETIQVTPGLMRKVEKSPETGELLTAIVYPPFSTSTAASSSSALLPAPYEVLFDEREWYPCVITGVVPPAKDVDRVQYKAWILGHNVEEVVYSEALRPWQPTASTSDIQGGVSCHVIHPQTGRYVEGVVDRLTLEETVLVKVPAAPSISTTVSTSPSTATTTTTTVTVPLSHVRVGKFYSQLRHRPKTEEERAARRVEQARLKRERVAQQRQLAADKVAKDADDWQALIGDMMGMDSGGGGGKKHKRRRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJ36</accession>
    <name>A0A088RJ36_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_090860</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PET117 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN96002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704324.1">
        <property type="nucleotide sequence ID" value="XM_010706022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJ36"/>
    <dbReference type="GeneID" id="22572656"/>
    <dbReference type="KEGG" id="lpan:LPMP_090860"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000051700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_090860"/>
    <dbReference type="eggNOG" id="ENOG502SA0U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270322at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031568">
        <property type="entry name" value="Pet117"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28163">
        <property type="entry name" value="PROTEIN PET117 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28163:SF1">
        <property type="entry name" value="PROTEIN PET117 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15786">
        <property type="entry name" value="PET117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN96002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="101" mass="11731" checksum="40BC0E2DDEE9C031" modified="2014-11-26" version="1">MNSYVKRYVGSDPTVQQLVGFKRPSERRLVIGCALTALAIYWAVYFSEEKERNRRHASIEKDIERERWRARELGLAAPTDDGFAERYAALQHKNTRLTSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJ89</accession>
    <name>A0A088RJ89_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_091380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN96052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704374.1">
        <property type="nucleotide sequence ID" value="XM_010706072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJ89"/>
    <dbReference type="GeneID" id="22572708"/>
    <dbReference type="KEGG" id="lpan:LPMP_091380"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090019300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_091380"/>
    <dbReference type="eggNOG" id="ENOG502S1Q6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273263at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN96052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="580" mass="62980" checksum="03BD2CDAB2A08FE2" modified="2014-11-26" version="1">MFNASQVDELFASTTRTLQRSQVLLDERRSTIQNQRGLPPMFCVASSSAASMSIGSSVAVPYGSASSSFVSTVRSLKSLSEFRSYVEAAADMMEKVREEATAPSPAMQQRRAKGQDFALLQSMTRGLRGATTAAWQTSESTAALWTSATEARGGTEEAAAAEDATAAASSAMCAAPGAHTGSTRSSGAQLTSTLIFSAFCVDIAISVPRAASCIVTELECVFQSSSENGAPPSVVSEWMRDGNVKLSTLLRDVASLLPLPVTMRLFARIADLLFRPPPAFLREPNGSSGHLLGCELLSGGQLLLPALNYYLLDQYPSTLASRWFLQPLQTTAEHLRADYYTSADQFHVQCRWLLRLVLTLLYACQSIALPTSTSSRPPLERRLRTAQRLCDTWLIPLERTFGSSTARHGMSASFNAALVQPHGHLVERLLLTTSPASSSSSLRKAVQLSREWSGILYSAQYRLLLILEKLAHSEVAQANGTSSTSAKQRTYESMLRQNGGKVSVSLLQTLAEDKQLVLDETPSRSPDGHRLYKLHDGLLSDSNGKAVFVYVDDGALFTKASRARAFQRVKSVEEIFKPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJE7</accession>
    <name>A0A088RJE7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cilia- and flagella-associated protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_030290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009372">
        <property type="protein sequence ID" value="AIN95264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700972.1">
        <property type="nucleotide sequence ID" value="XM_010702670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJE7"/>
    <dbReference type="GeneID" id="22571895"/>
    <dbReference type="KEGG" id="lpan:LPMP_030290"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_030007900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_030290"/>
    <dbReference type="eggNOG" id="ENOG502RQYB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264785at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049270">
        <property type="entry name" value="CFAP58_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083:SF0">
        <property type="entry name" value="CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083">
        <property type="entry name" value="CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21771">
        <property type="entry name" value="CFAP58_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cilia- and flagella-associated protein 58 central coiled coil" evidence="4">
        <location>
            <begin position="360"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="917"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="146"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="223"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="447"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="721"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN95264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="946" mass="107428" checksum="D7ED395950392C62" modified="2014-11-26" version="1">MEVLRAISAEPQLEPFRGEYEKLHRLLLSSHDGEQRLLRQVRELRNELDTHHQQIATAMHLSQEDEEAIRSLRSEIEAAWAKADAAHDQEQRSREILHTLRQQVTELDATVERTAGLSMGQEAYLRNLLAVKKDREEESVVLHAALNRTEAEHRQVCAQLAAVEQAHRAAQHELEVQRRAYQELLTSLEVEQRERTAKEASVRQYRDTTELCMRRLDERGVEVERAIRDEKRASKEAEGMAQEIQAIARQLQERQERFAVEAARLAAAERENTMLTHELPQRQAALREQQDELKREEKKLRGLEKSARAQQQELSALVEKRATAAAAVQTRANSVDTALTQLAKEEKDCGVLEGEVAKAMQRKTSTVHTNTLKATASARVEGQRVIEAGKGRRLEQQLGVLRTENEQMRKSIYYAEQNHEKHTKEAQQALLNYHRTLDTIRARRSEAKVVEENIVHHQKKLKAQQELLNTLAVDRQKTEKALQETEAELLLLRNRHTGKNEELESVKTELIQQEADMCQLHGLSRQLNKDVANTEQRLRFLREDRQHAENRVEALRSESQQLRQVISQYDLEARQQGARLTAIKHERNTIAAQLLLRSEEIELVREKIRLSDAARVSGAYKYQRALQTLVASRDSLVEQRLRCRLALVRLRYLDRLHTKELQQEKLLSKSRARVRALADELGTKHNVHCWRSMESNAPEVLDALAKVQLLQAKLLRRHGELKVKTDLVEQEERAYQQLRQQLAKLPGPEAAEELALCAENLQQRKAQLLCMTDSLAEAEQEAEALEVHVTQLQEELQDLKHRYYQEKTRHSVLQQEERLAARTWGAGVGAARRAGTAAVSSVGNSGGAVVAAGTLTPSTQQRPHLHAGGSTLLNNSHCGLTAAVRGPAGSGSVDNASVQHRLVRQRALPDEAMLNTLTAGPPRPNFPLQKPPHQRQFVGGGFSLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJG6</accession>
    <name>A0A088RJG6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc-binding dehydrogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_100530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696775.1">
        <property type="nucleotide sequence ID" value="XM_010698473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJG6"/>
    <dbReference type="GeneID" id="22572789"/>
    <dbReference type="KEGG" id="lpan:LPMP_100530"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100011500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_100530"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3233595at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:001131">
        <property type="entry name" value="Zinc-binding dehydrogenase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052733">
        <property type="entry name" value="Chloroplast_QOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44013">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C16A3.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44013:SF1">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C16A3.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="59"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="432"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN96122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="479" mass="51362" checksum="D2883C3B2D9E4DEA" modified="2014-11-26" version="1">MGSKNSANKSAVPVPPPFYVLPDVPVPSLKPSSLDFAETTGKPILCAGWIAPKGDPSWSRRNVVYSSDIEIPVPQSRQVRVKVYAAGVNPTDVHRTAVLPRSPEVGSRGKGRHTTRHPRPPFKFPYVVGIEGAGVVESVGWAAGSNGEEDDSAGALASAGASDIHVGDRVAFLADFTQGSGGTFCQYAVVDSDILWKLPEVVCSPPFPSTGGLMPGRLIDFVEAASLPAAAATAYIALFDKLRIETQRSIFISGASGGVGSVAVQLAHYFGLYVIASCSTPNVRYVQNLGADYVVDYTRTDVVKDILMYTDSYGVDYLLECADASMAEAHSETVRLGGSLCVLTGLFTPSSDMVFRRQLSVHYVFLGLQHQDPLARMQLKPLGELVMQLYIQGAFSVNVEQVPFVQATDALEVVASGHGRGKIVLTNFHVNEDQEERQRRRHAQLYEKAQRQHQQIEMQKAAGAAAVAVASGAASRGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJP4</accession>
    <name>A0A088RJP4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_101130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696835.1">
        <property type="nucleotide sequence ID" value="XM_010698533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJP4"/>
    <dbReference type="GeneID" id="22572850"/>
    <dbReference type="KEGG" id="lpan:LPMP_101130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100018400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_101130"/>
    <dbReference type="eggNOG" id="ENOG502R309">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="448087at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039902">
        <property type="entry name" value="CCDC148/CCDC112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21549:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21549">
        <property type="entry name" value="MUTATED IN BLADDER CANCER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="421"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="542"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="566" mass="63399" checksum="6F651236ECFBBF82" modified="2014-11-26" version="1">MHASPRANAFSSASVQAAALKEWRKSSSKHKEAASSLRQKVRQLKSDAEACRRAVQWMHERDVLNAKQETCEAALVAMEKGLGNAVSDADNECHHRELSALKIFLSQQLTEVDALLCTSTAQESQNSSSSTAEDRVAHIREWIAAELTKCETNMAALAKPSADLEHQPNAVTECRAVARQAQLTFAALCDSYHPAHQLRDTFEVALKSVEEEVLARIKDASVSTAIATPPDVLQTVELIVRMGQHARQFDISAATMATLTERVSAVYPGMPSAQVHVAIEESIALRKERVLSQAAMSDFQRVNASLLSSCESAFLVAQESAKQRQEKTEAARQRVAAQNQRHAHLTAERAAYEAVLRHRQSIEVQMQAAVAAKEKALQAKRAIEFQERLRLFEAYEVQQAALRQKERELAELQAQALEEEKAARMHRNEERVKYRRQRDEQRHYEQKKHEHELLALRAKRQEALQRFFASVDKQIGVETDPRRLLKATTSSAQAKQYTTLAQATRPSIPGFSDEEIMKDPRVRLYHALLAAGLHTTPYGREMATRGYRVSPAQQSSEGNPLRSEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RK27</accession>
    <name>A0A088RK27_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pumillio protein 4, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">PUF4</name>
        <name evidence="5" type="ORF">LPMP_120390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009381">
        <property type="protein sequence ID" value="AIN96367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697020.1">
        <property type="nucleotide sequence ID" value="XM_010698718.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22573045"/>
    <dbReference type="KEGG" id="lpan:LPMP_120390"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_120008800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_120390"/>
    <dbReference type="eggNOG" id="KOG2049">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF50">
        <property type="entry name" value="RNA BINDING PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="4">
        <location>
            <begin position="973"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="1035"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="1073"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="1245"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="1286"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="22"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="451"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="617"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1155"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="303"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="638"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="733"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="782"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="841"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="858"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1155"/>
            <end position="1169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN96367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1435" mass="151387" checksum="0EF5044DE83E901A" modified="2014-11-26" version="1">MFAQAESEELLHLLSQVRLVADEEARNEQEQDQQVQREQPHQRHHPGTGSERTISLYDSALSATAEVLGKQRSNGSSATIASCSGGSAAGRYTASSTAAVTSSWTVYDNTDSSFLTDYEHDHANSLNQPPVSRTPATDAKVLPQRLDERARSVEEGLAKRGDGYNVFREPKQLLFTSPSAATQVATLQQRPSPHARQSIPPSHALTAYTTAVSTATKATTPLSIDDAASILPVAVNRDSSDYLSTTVDSAMFRGTPLAVVVPSVLSGYARREGTVVGEGGLEGVSYTAAAIRKEGADGDGEEEFGRAGDGESGGDRLSDVWTPARSAETPQSALDGSTRSIRAFHPPRQQSHQQLHQYHTTLSSPSSAAEAAVAQFFRGSSSLDALDSGGHDGAWRACVEAELAELQRGGRLLTSGSAGATVQGTSISTVSPLPPTSTTPYHQLLSRLRHSPSQVPAGGLGSANTASVGGAARANTPPDRRQLSFSRLSSMGPTSVYTANITNMQWPSSSAAAADTSTEQGRSCWLRTNLTPSEAAALWECLSPYERATAAAAASSNAASVAAAAALLHTPDTVPKPVTLSSIAAHLHSGVGDPGIPEVTYEAQPYAAGPGHTFVSPSAFTTAPRRVPRPASTAQLFPPSSSHPSPAPTATTGTRVSPHHGWHQGNSNHRQEQHSHTVPPRTSAATTMALPPPPPPASTPSLPTTEARGSHRSQQHNLQSPSVRRWSPVDASPSITSTGHIAGNATNSPPSCSLRPSPHPRPSNGSSPALRRYTIITPSGHTTTATATNSTNSGGKKRMGGSPLDPNGTSVAAREASREARPRVQLSPLTYTTGVGARGKSSSSYHHNPSSLAAHHLNSPSTSAVATTGSGASMVSPAAVQALIQRLHAAAAIVLPNSPSASPVVPGDGQLSRTTEESKVAGATAVPDVASAPIILAMSHDQHGCRLLQAVIDAECSEVEAFDGAHDELAAADNAAAAADRAEAVRDRCMTVSPLGVTGARAGEKGSVGNSVRECRRRRAEAFENSIPVRVVLQAIEPKLDAVMADGYGNFLLQKVFDMAPDAERQRLLRLPSLQHHLCEVACSPHGTFAVQRLVETVRNAEEEHLVFVALERDLLRLLTNANGGHVLMKVMECIRRQYIALISGTNSAAELSPAAMAATPARTPTTASGESSTAPSRRLLEERVEVLFQAIQQHLLYVCQHKQGCCIVQKCLDFLHACSGLSPPSRLSPSPAGAPMDYFERMAALLLPHVQELSAHPFGNYVVTRLVDVCYARGTTTTIDAVAAGMQQDLVRMCTNKFASNVIEHILRHCSERRIRLLCQSLMVSATPPSASAVYSSSTSMAASAAATNAAIARLPLSTVVMDPYGNYVIQTLLTVAPVDELVNTRAEGGGMLPVLQQLLPLLSSRNYGRKLETKTELALLRVEQHQQQKQCHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKL0</accession>
    <name>A0A088RKL0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_131300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697210.1">
        <property type="nucleotide sequence ID" value="XM_010698908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKL0"/>
    <dbReference type="GeneID" id="22573240"/>
    <dbReference type="KEGG" id="lpan:LPMP_131300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130017700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_131300"/>
    <dbReference type="eggNOG" id="ENOG502S3HM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7451790at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040091">
        <property type="entry name" value="LRRC56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22708:SF2">
        <property type="entry name" value="LEUCINE-RICH REPEAT PROTEIN (LRRP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22708">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="362"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="591" mass="63799" checksum="68EFC012592521AB" modified="2014-11-26" version="1">MSIPHLTAEEMAYYASLSLADPDEAELAAFLAGTQQEHVGHPRETGAASSSTAPSAGKNGSTLIMSRCAPTCERFDSSDVEGLPPRCAVVPVNRWQSSTFASTTLARWLSSAGLFPEPKPATLDNSTRYGITQVLEKDNLVGGVAGIADAALQTRYVDLPARQLTSVASIQCFLNATHVYLQHNALTNLEGVELLSQLRVLVVHHNQLTSLAPLQQLDNLFYLDVSHNNLSSSMDVLLRNELPCLCLKSLNLSNNPCWYRCGGRASDVDGEKQPRTYVQQMCAACPLLERLDDVDIDDGEEVVQHSDSSTESDVSDALVRRSTGAPPSRPRSIAIRRVHDAVEAARAASLRASVPHMHPCHSPASSDSLSSSGGAELSIRSQSAGKASKAALLEEEQARLVHQLMLRRAADAAPESLKVVDTLSTSPPHFNRSTAGNEHSQPGAATTEAPAELKVTPPAYSTADVSEFYGARSDTLQLYRNLQFTQEVSQARLLRDLAAHWDDVSRVLQTAQALQQDRRRRLQQRLQAHTPAYTESLTLLEKESHAKDLDRYRNSGVHRKGTPTSIHVVTGAPVSPPAAAGANVSPAVDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKP2</accession>
    <name>A0A088RKP2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_120720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009381">
        <property type="protein sequence ID" value="AIN96400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697053.1">
        <property type="nucleotide sequence ID" value="XM_010698751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKP2"/>
    <dbReference type="GeneID" id="22573078"/>
    <dbReference type="KEGG" id="lpan:LPMP_120720"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_120011900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_120720"/>
    <dbReference type="eggNOG" id="ENOG502RD41">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5511466at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009305">
        <property type="entry name" value="Mpo1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34205:SF2">
        <property type="entry name" value="DUF962 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34205">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06127">
        <property type="entry name" value="Mpo1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="108" mass="12107" checksum="B05D44AC3BE99B9F" modified="2014-11-26" version="1">MVSFTPQLQVSCSSFQEYRRYYQCTHRNIWTRRSHLVGTAVAAIAAVLAAIRLDFAVLVSSVTAGYLICWGGDVLFEQRNPASFQNPIWAFCANMAMVQDVVRGKETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKQ9</accession>
    <name>A0A088RKQ9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-hydroxyacyl-ACP dehydratase, putative</fullName>
            <ecNumber evidence="3">4.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">HTD2-1</name>
        <name evidence="3" type="ORF">LPMP_070480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.2.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CP009376">
        <property type="protein sequence ID" value="AIN95734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704056.1">
        <property type="nucleotide sequence ID" value="XM_010705754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKQ9"/>
    <dbReference type="GeneID" id="22572383"/>
    <dbReference type="KEGG" id="lpan:LPMP_070480"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_070009900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_070480"/>
    <dbReference type="eggNOG" id="KOG1206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3592703at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03449">
        <property type="entry name" value="R_hydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000042">
        <property type="entry name" value="MaoC domain protein dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050965">
        <property type="entry name" value="UPF0336/Enoyl-CoA_hydratase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43437:SF3">
        <property type="entry name" value="HYDROXYACYL-THIOESTER DEHYDRATASE TYPE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43437">
        <property type="entry name" value="HYDROXYACYL-THIOESTER DEHYDRATASE TYPE 2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="2">
        <location>
            <begin position="14"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="157" mass="17012" checksum="B66C58EEF66452C5" modified="2014-11-26" version="1">MQAAAHRIIRVGAQASKTVRITQRDVVLFGNLVQDHNPIHSDAAAAKAAGFPSPICHGMLAGSLFSGLMATELPGPNTVYLSQTLRFLTPIFAGDELEVIAKVTQFRRSTGLIEMSTIIQKANPTNLGTKITCIEGFSVGMNKLVEFEGESEWTRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKS3</accession>
    <name>A0A088RKS3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_140250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697260.1">
        <property type="nucleotide sequence ID" value="XM_010698958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKS3"/>
    <dbReference type="GeneID" id="22573292"/>
    <dbReference type="KEGG" id="lpan:LPMP_140250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140007500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_140250"/>
    <dbReference type="eggNOG" id="ENOG502S0SD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269298at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="172" mass="20167" checksum="5333FA1362BF2C57" modified="2014-11-26" version="1">MAPKRESDEALLDARINANRLEYPEQSLIFVALITSFQPVYFSHAINGFDWRHAPNLVLYLIITGFTTYMLRQAYVVMVQSEFWGRQRHFAEVSDEKSKVLRRLRLQVAVGYSLFFLNSVFFVVSTCLMAYIFRHSDPRASYILSPTLTAALLWLIAQKNEESRQRRMRLHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKV1</accession>
    <name>A0A088RKV1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_130300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697113.1">
        <property type="nucleotide sequence ID" value="XM_010698811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKV1"/>
    <dbReference type="GeneID" id="22573140"/>
    <dbReference type="KEGG" id="lpan:LPMP_130300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130007200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_130300"/>
    <dbReference type="eggNOG" id="ENOG502QPPP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271905at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052587">
        <property type="entry name" value="TELO2-interacting_protein_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18460">
        <property type="entry name" value="TEL2 INTERACTING PROTEIN 1 TTI1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18460:SF3">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="874"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="875"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="892"/>
            <end position="905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1095" mass="119940" checksum="2DF173B6633FDD9E" modified="2014-11-26" version="1">MQEMFLSSVLLPLTEKTGEVERVDELLGMLEHCFIDAFKLSPSSGNKSDADPQSNASGTSSSLFPFPSSTLDAGEEAKLLAVRAVAKFHRTGAARHSYFFRTRDYHPHAALFILELLKSLNGNSQHWFRQLQLDSLDACLAILEVIGMENVRLCLPGVVSVAVRYIHRAHHGKDSTKVCLSAIKVLCTALTIGFGAAEPETWVQDAEVHLASALRSIFVPSVLVRSAHAPVTVAALKSLIVSVLLSSAMTERTNTPLGSLLMVAYAIVENMDHLHHLGDDVVGAVEAASSIVCTGSSLRNSTDDARMNTLMGSSWAVLAVTEALQYLRGVELLHLATTVARAPGLRDRFFPLQAPPQAASSTAESPDVSELAVSIFLSVVRKCVRVVGTEMDEAALYSHRRPRKYPAGVVDEFLFCLAGALARLPTVATLTPDCRDDDFGDGNETVGERLTNALLTEYDAVLQDWDAYAVHPAVLYVLPRLVVWQFHPLQVLRSLPSCFPPPTAGMVVPNDEATRSCMYPHPADLTAGSFEQLWSIVAQPHLWAVTQDEALCTYQQVHHRQVVAATLLRILALSAEVLACGDWATTERPDAERAEALERLFTLTLYLVLEKAAASGILHEAALHCVEVYSAACGETDTLLFLLRHSTLIVDETARAVKEEHLRPAAASVLRGSLALLERRFIRGGEGSSNDHAALGFSGANLTALVRQRLSVAAMSASFTRGPTKMVSLEEAAQVADFVSSTIHVAREALQLCSRYDSTVVAEDVIGRRAALSLLRDALDLAAYLNYCVPQEAMCEEQERHTTSAHARVRALQSVVLEAVYAVLQHCTLHDQVAAIAVQTAVRGLTCFLTTTAALTWADVTRQRLISEAEERRRLMQRSRRDGHKARLMAGEGEEDGTAEDESDDDPGRTSLPTPPPIDWPWTHYAPTVVVAAEAATSVEIELPRSHLHTIYRVYLSLFALLREPMAAFGTIAAEPRARAEVERRNLGNVVVTPALFETLSGLEAIRLLACDFLLHRMVDEVLPLVLLWHERARLSRIPTHTEERAKLATQQFVEHLYEDCRDSAELHESMMTKCRCFDLCTTPPPKPGVSNPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKX1</accession>
    <name>A0A088RKX1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP-3 complex subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_080090</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Adaptor protein complex 3 (AP-3) is a heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="AIN95819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704141.1">
        <property type="nucleotide sequence ID" value="XM_010705839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKX1"/>
    <dbReference type="GeneID" id="22572471"/>
    <dbReference type="KEGG" id="lpan:LPMP_080090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_080005800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_080090"/>
    <dbReference type="eggNOG" id="KOG1059">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264595at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017105">
        <property type="entry name" value="AP3_complex_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22781:SF12">
        <property type="entry name" value="AP-3 COMPLEX SUBUNIT DELTA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22781">
        <property type="entry name" value="DELTA ADAPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037092">
        <property type="entry name" value="AP3_complex_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="9">
        <location>
            <begin position="28"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="671"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="734"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="762"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN95819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1124" mass="124151" checksum="1DFF4CF485B8FE6E" modified="2014-11-26" version="1">MSLAAFSQYSLAAVVRSLRSAPGGTEEAAVDKYIADTKNEANVADPQVKMVAIQKATYFYMLGYSSQYANFRIVELMASPFFLHKRVAYLAACLTFTEDTDVIPLMTASLKRDLSSSNQFEVGLALYCIASICTPDMAQDVVVNVVNLLGHPRAYVRKKATLSLYRIFLSYPESLRVTYGRLKEKLEDNNEKADTDPAVRGAVVCVLCELARRNPANFLGLAVPFYSLLSSVHSNWTLIKIVKVFGYFAPLEPRLGKKLVEPITSLISTTTAKSVQYECLLAVANGMSQVLSLKKLAAERIRSFVEDADPNLKFLGLEALSLLVSSSENRKLLTDQREVVLRCLNDPDSTIRLKALHLLRDLTTRKTVVSHINQMLDRCVRTPLDEEWSNAVIRTIIETAQTNDYEWILDFEWYLSVLLDLCVVELTVYTHGAFMEQELVCILSRVSGVRRAGVEEMVGLLTHVRLLRRDWQHSTQWRILCAAAFICGEYPHWVPDIAETCRALLAEPITLLPAEAQLACVTAVGKIAAYVYQPCARHVELRNGEEDCRGAEEGEERIVPSLANLIQTALLPETDEVSVVFDSSAERDARGAVAQAHRGLRRFCHSTFPSVSERALLVEYQVVEQPEVGPKLYEADLPPVAVGAQDAIEIPEGLDLDAPFCENVAALMSLSGSEDSDGSNGGLGDGEGDDLDSNFNLEYRIEQQRRTEQARREEMAAYYLRDSADANVVVPKDFGASPPPPRSVHQIEGDDGLDSHAGAASHHNRHTRTRRPQKVFSINRQLSKPADYEKKVTQLRRSNSPEEDEATRKLRSIDVTRALGADERLPETLSYEQLLQKQQQNRCGNRLRVDAIAALQASGSAPVTLYNQSPLRLYMTVTGCKVRRDGFHLSCAVECVNSTSSIVVRDVQLTLVPTTTVDMGNVALQLEAVESEVAEDAGGGTSLTIAERLKSSAMVRVPIVVRLSRLPPSFADAPLSLNLTWTAERKHCQAALTLLLEYVYFTKPVLPGSVLTSHEYLEEVVGKSLAAAPIATAFLPCSKTAIMTGVVAAMPQLRLSPIDVFKDALSMYGLLHGRKSELARTHVAVLLQEQEVDGSKGILVMVRCHYPMLSKALILKLAELVGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKZ4</accession>
    <name>A0A088RKZ4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mitochondrial processing peptidase alpha subunit, putative</fullName>
            <ecNumber evidence="3">3.4.24.64</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_130760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.24.64" evidence="3"/>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697158.1">
        <property type="nucleotide sequence ID" value="XM_010698856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKZ4"/>
    <dbReference type="GeneID" id="22573186"/>
    <dbReference type="KEGG" id="lpan:LPMP_130760"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130011900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_130760"/>
    <dbReference type="eggNOG" id="KOG2067">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277191at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF227">
        <property type="entry name" value="PROCESSING PEPTIDASE ALPHA SUBUNIT, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="2">
        <location>
            <begin position="71"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="527" mass="57968" checksum="22F6C76B21E81519" modified="2014-11-26" version="1">MLRRVVTSAPAAATAASAVQVRSIYEYKFGQVPLTQPFGGTSRMPPHHPSNPVPAVAGKVEITKLHNGARVITHNLGGPSVSVGAYILAGPVYDPPSAPGAGAMLHLALTTSNFNNSLFQLDRNIRSVGAAQTHFEKNKHHIGIRIDARADKWRSTASTSSRTQRRQLQNQKQAEQHLPLNLVQDNIFTCIAAPRFHESDLERFRDTVDNQVEELRWQYPAEYAKQMLETVAFYCEPLGNPRFVPAISNSLITSSVLLEQYSRYVVPSRIVIAGVNVDHAALIAEYENTPFPHSASAPHHASAQPCKVNSKDEAAQYTGGERHDHEDRPKAMGTKPDMNTESIVAIGWLAYGKDKKMVKDHASSMVVKALIDIELNDSMRYARDETHEHMCLRAFYCPYQTAGLIGFTVKAEPQAAVRMVTDTVKMVRAKKAAAADSVLSVAKKMAKTQFMVQHADTIRDYCDYLGTCLPMESDSTVATSLEEVVDAINSVNAADVAKVYEKMFANTASLYSHGEVLGFPSMRQMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RL77</accession>
    <name>A0A088RL77_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_131480</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-13 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697228.1">
        <property type="nucleotide sequence ID" value="XM_010698926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RL77"/>
    <dbReference type="GeneID" id="22573258"/>
    <dbReference type="KEGG" id="lpan:LPMP_131480"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130019500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_131480"/>
    <dbReference type="eggNOG" id="KOG0246">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007019">
        <property type="term" value="P:microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01367">
        <property type="entry name" value="KISc_KIF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09541">
        <property type="entry name" value="SAM_KIF24-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000012">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971:SF6">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971">
        <property type="entry name" value="KINESIN-RELATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 6 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="11">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Kinesin motor" evidence="10">
        <location>
            <begin position="198"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="74"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="550"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="702"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="576"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="594"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="623"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="290"/>
            <end position="297"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN96575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="729" mass="81082" checksum="FE206EB4D6FF7224" modified="2014-11-26" version="1">MMESQLKQLLVQGGLEHTVQGFVEGGVTSVQQLKQLTMQDYHSVGVIVMTDRRKLFELIQFLKRDQANGSGGCMGGPAAAVASTSSKSPPPAAEPVLRAQASAHGSAAPARVFTPLRRATPTEAIQRREREKVEQPRPMSAQRRDPNADEGENAVRSAAAPAKPLSRPVSRVGASSPSPFGRRPTADGGNAQRRRTSRITVVIRKRPLNVNEHADGLYDILATDPDNNHIITLLEPRQKVDLTRYIEKHRFTYDKVMDDRKTNRDVYEEACKPLIETVFEGGCATCFAYGQTGSGKTYTMLGKDKQEGVYLMAAKDLWSRLSRGMGINVSFFEIYGGKLYDLLNERERLACREDSRGVVNVCGLTEHRVDSTDHLMEIIDYGNTIRAAGSTGMNADSSRSHAILHITIVNEKNRFFGRFTFIDLAGSERGADTLDSDRTTRLEGAEINKSLFALKECIRALDQNHRHIPFRGSKLTAVLRDCFMGNSRTVMIGNISPASGSCEHTLNTLRYADRVKELKKDRSSHSAAEEIMMGQMPTEHIETVGISGSFAQRRAKERVVTSSRSSSQTRTREPGTPNQKMGNSFNRPGDDSSDNTLRSNRSFGSRPVTRNSPQKRYYYRPTPTHSRGPSGMSSAMPTPMGDDSRYDSGDSLDAEEDHLILAHRHHIDCMMELLKEEMTQLNAAENPENSMSGYCRRVDAILSSQVRRIEELRRQLDQYTRHAGAAGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLQ6</accession>
    <name>A0A088RLQ6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_100500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696772.1">
        <property type="nucleotide sequence ID" value="XM_010698470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLQ6"/>
    <dbReference type="GeneID" id="22572786"/>
    <dbReference type="KEGG" id="lpan:LPMP_100500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100011200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_100500"/>
    <dbReference type="eggNOG" id="ENOG502SK9U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272911at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839029" evidence="2">
        <location>
            <begin position="24"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="764"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="776"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="837"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="859"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1044" mass="112774" checksum="9BAAEF9C1A9DACA0" modified="2014-11-26" version="1">MPPLPRLCLGVLWIVFAVGSCACTVAEGKPRPPYTKPVIQTSHDDAFNPESSARESVLPVDFNTIVADPFLTPATLLEGTRSTGKAIAPEHIFTNPTLRLVFDVPNTGLDFVINFTSAKHPLIQDPNGTLWRSVLPSKIEVVKQNTKYTYNVGNLSLKSYRSQSESVQVVAGAPAADAECYSSKACCAVNSSYYSKYELVDSPVPPYVCTGAPVPYSLRHFTFNVHSTAKFREASAVASCEVKANPWGEASVTCTASSSVVMGGVTASPPYRLPSRAYSLCRQGDSLANPESVSSPFPVVLVSFCPERHCIGYTPANYRSDRGACINYPLGFYTSARGNNTNQFSSFEEDAAGLWPYFFNGCKWIDDVTMSSTTIQDISFQCDVPESTGWSLSYENFSAHLTDTIAPLFPIGRPTRVSGQYANPTDKDTILFEVEYVSFSRFKAGRWTFRICAATQCATPTFPVAGDTGHYPNVMRVSVSASKLGLSTSPYEPTVIIEVYSAITPTTSPFRTLLAPSVVHVEKAVTLSSQDTVNMTLARDPPERVLSPYAASTSGKTTSRVLCEGDYRFSTLTNNCQPLTDKDCATKYRGRRSKFDSATKACAYSVPPLNGPLVFKSLAEPEPPRLYSPEELRAILKTVKLPQFLRTMEKSYEEYERQAARRAGRPVRLPPGRAAAAEDTDVAAAGAADEPAMKYMKEPSMPGSRGLTIACITATCLLWTVALLRDVLFKFFAVGPWDGLRPCAGLAGAVGCWHRLGGACARARREEQPQARNAASNTTATPMTARLPTSPNRTQSGQRGGRPNFAPKTQKGNGATFMAGTPLPFTTKAPHAAPRESATSAPLQSKDPTPPLQREKRGGGKKGRRPRAQRSRNAEQEHPPNVPAGVKRPASLWGGPRPYVSTGFHPGHHAFGFPEAPHVPFGREAGVAASAGVPFMGGDYAGQSAVFPDEGVGTGPVPVAFSRPHSASSQRWYSSPPSGWRPFENVCSPLQSPRYAPYDAPLSEFGLNPPSTSLDGLGAFVPASFARQSSRVEVLSSDTDERTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMB4</accession>
    <name>A0A088RMB4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_161200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN96995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697648.1">
        <property type="nucleotide sequence ID" value="XM_010699346.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22573699"/>
    <dbReference type="KEGG" id="lpan:LPMP_161200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160017300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_161200"/>
    <dbReference type="eggNOG" id="ENOG502SIVS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273563at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF10">
        <property type="entry name" value="OS12G0136300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="652"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="807"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="936"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1252"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1462"/>
            <end position="1565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2008"/>
            <end position="2096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="581"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="658"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="675"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="818"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="937"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="978"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1252"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1274"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1490"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1516"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1548"/>
            <end position="1561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2013"/>
            <end position="2022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2036"/>
            <end position="2059"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2154" mass="231660" checksum="D94A73746AC44CCE" modified="2014-11-26" version="1">MGCANQKSHAQQIAYQREFLGACWNSALSDDEAKEYLASRWMGISRPVMALHTNNHCFTVRALCKEKKTVAPTTVDPSKTPVAAPGNPTGARPDLGGSLGIENGGLCSFASASVGGSSSTHVPLLYPDRVPYLNTCLPITAHPEPTPAPTGNSVPAKTSTTSCPGAGSPRTTMRQGHTSSHGCPHPANSDPESAMANAFITAAITGKTKNAESGTLRTVMKDAIELERIAHSHHPYLQRHELSVYGGVVFRCAPAHRLYHRISFVPEPRAKRLGNAPLSAVADSRQDQQQQSALSTPLVTPSGVAATDRDRSRMRGLGSPLRRRTGGVKRSPIRRSDSEQADDVSTLRLGSSMARHTISSGSDWATVDPLSPSNNYPIEDRDIDGVAATRPPVVIGSITAMELQALPPSAELCFGGWLYVSLQDEQKRLRRSLARYEARRQQRAARRKAAASPILSSTWKTLSTSCRDSRSQRQPQGGRWHNCINGENVEGASGHDEYPLLRASVAAHSTSAPQRPQQPCDSSDELTTCSQSPAEVAPPSPLNAALVDSQASPPRDASRKPSVIEDRSDASIAETEGVPHAATTTADTSPAAEAANPHVDGEKEPQLAQGTPQLSRAQSEERATPSIETTTAPPQPHASFSRVSALDLSASMKSIDASSEHSPIRKLSEPRKRTTSASPQQTEPPLRSSSSLLATMRRTGKYAQEAMEADALAASWLPYAYVIIAVPMYECSLVPTAFHTAFTRRKAVSLNLANAQSRQAYGVGCITAARYGGVMVVEYREKISENEDAEWIDELLRVGCASQKEYSKAGAKPDDTDTTNPPGFSGSATARASAPSLQHFSRTVVHHSRAEKLRHIKARIWDKLRHQGLYVVLAETRVANRRHRQQRASVTNGLNMTFQASASWLGTPALGDEDEEEGGVGFDYYARDASAVDYDSLSDNRGTGSDSSSSHVDLALRSSGRRRRSLWLQLSRGSGNGSRRHRRRQHRRGNHRSDYDDAVLKGLRPTHFGSSDQRRSVGGRGLTTTLVDSCRWTGQNYDDDDFLLRGTYRQIGGMKYLDVVSLIDGCPVSELVQGIKRWVMNLLSMPIKARPLSLYLQRYEGIASSLQLLSTQLASAALAASVASGHLIAPANLSFHAGGVTGQEEAAASFVSQQQVEATGGRVSTCSFSLASVTLMSASAAALATQVLPHGVSYNTYYKGPLDPVVRAVLSPELELMIAACQTRQLPEIFRTPQSTAAHMVTNAGATNAGLSSLNSSASVARRSSRDSHRRNSGISSPTPQFLPSVSSSDPGCVASGEAGARAVAQVQGSPPLPTGLSPAMPCAKYPFCVDVKNHPSTSASNDLLPAPLLPSAMLPAVLSLKHKSVEDSSEAAERLPYDNSSQNGSMVGNSCTAVNGRALAAAAVPAAAAGLGDGIDNANGNGITNASFASPLNTSLSSFRVFKSGTVDIDALAVPSLVQSGKQQEMPLLRSSCPGDAAAKGGTAGSGTRADDAAEAEKPRRVRDSDSNASADPRSTPDDANHPRQRPLRERPAAREAAATECHDNSGENSASDENHSGTAVRQRVDRAAALAGAEEEKVPHREREWQVADRELRVLKSELYELHYLVSIARSELLERLEESIQLGAIFLPHTRPDQVALSLLTLKMMRQYPEEVPVKEIHTDWVPMLMSLLTISRDNMFCCADGLTHSTSGTWDFLKTYNNAVAQSDVCDGNQRRKLYDSGTTKYTIDPLPPLPAPRPLHDIVIAPQPVRFTKEALHEIKRVGMDESGLSFTFSGGSFGVLAGVLYYYADFLRAKYRSEVATASGRPKEAGATVQDVLARGGFNVFLRRIWVWGMMPDSSEYKFPISTATTQVKQLLRRKLSRRDNANSASSAEPKSARFADGVDYVVTNTAGLDSGSTRMKGKPFCSAEAYALYDAIVHYLGTLEELHTEHQGNASIAAQGLVRRRSTLMAWRRNKGGPDAAFVADENSGEMCSLTGSAAASLAAELVPSFEICVATNYYYKEMMEEARRPRPRARRISSLHRTQSKTAGGKRSTVASLSPPAASSGAASGITSAAVGDRKAEASIPPPRPVGSAGNRAKASKDEVLGKAQQQQLEVPYCGGEEKTRKKSPQRQAVKTIFRFLTNHYEQWRAKHSDDPVVSALAKRVHVSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RML9</accession>
    <name>A0A088RML9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Calpain-like cysteine peptidase, putative</fullName>
            <ecNumber evidence="3">3.4.22.33</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_181060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.33" evidence="3"/>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697940.1">
        <property type="nucleotide sequence ID" value="XM_010699638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RML9"/>
    <dbReference type="GeneID" id="22573996"/>
    <dbReference type="KEGG" id="lpan:LPMP_181060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_181060"/>
    <dbReference type="eggNOG" id="ENOG502SK8R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="424753at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF430">
        <property type="entry name" value="CYSTEINE PEPTIDASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="2">
        <location>
            <begin position="281"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="758" mass="84463" checksum="6BD3B9E0C7711F6E" modified="2014-11-26" version="1">MAATQKQTYLSVCKQLNEPPLRQLLETLEYGDARLDVSGIYLPRRHFRCFLHFIEERPDIEELILDGVDVGVKEAKLLKEHLLCSCVTKLSLQRIKLDSASANIIRQLCIENSNLVSVMLPETYVPSYLVDEIMLIVDLNRLNVESLRSTNTAGVLQGTSTIARWKLCRGKKDHSFSSALQLSSSATKRMVDDFVTSYKSVFIDFSFQPGTFNHPVAGIEAIRWSTYCGLSMFHKGKRDGSKGLFSPSSHYNNQNLCATLNILRFYDILSKSLLLERYPQSGLYVFRFFVDGLPVEICVDDLVPCVYVSGRCTVVGLSSCCSPFYAAILEKAVAKAIGGYRYLQELSLCDYIELLTGCTCFEVNLLRQSPVSTTFDTLRSLNEDGHKLVAYAIPRTLIEERILEDSGMCCRIPFTILKTDICQKHDTHYVFLVQLAAPLTGRLLKYAFEYEIYKTEEVNENCVFWLTFENFAAAFERVFLLLWPFDDAVLNHKATVEFQAASEFLSGSSQFAKNSSFLIQNEGGSSTPVMVSLVASSAPHTQIGAQCLFYKGVGAGNEASQRHYNVSKNNAVFESEEFEGNEGAVFFNLLPAECLQMTLSSHVPSSFRIRISAVGNVSGIQLPDTMVSLTFSGKWNTLLKAKRFSDDILRLRTIDGERTINLVLALSQATGDSPPFPHGVLGWNGTSTNVVDTTKPGFSTQQEKSTLCVHSFVLTLAAGESIFLLPYCCGGRCPDGYDLTVFCEERFAQSRVKTTSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMQ8</accession>
    <name>A0A088RMQ8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_130900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697172.1">
        <property type="nucleotide sequence ID" value="XM_010698870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMQ8"/>
    <dbReference type="GeneID" id="22573200"/>
    <dbReference type="KEGG" id="lpan:LPMP_130900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130013300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_130900"/>
    <dbReference type="eggNOG" id="ENOG502SDBB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273180at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="327" mass="36089" checksum="ED5DFD0B5BE0C313" modified="2014-11-26" version="1">MRYRQPNCHLSSKDQQAKLLIDCNDILSTQEQEEVIAYFARSLRGNTQCLKVIVCLQAVLALVYTVLLLSGSLLIDVSVDVATTSSLVQLAQQQQRGSLEPVTAALTSTAPLQAPPAVLAALDAEQRAAQRKYVYDYMNRHRAAGIRVQSGGAITVLSAMVMLYSIALLLWAAWSCYVVCRRLRVNIESLTRTEPRDLHRRRPEGSPSHAAAPAKPRLTLCRLRQRVKADPAVALYVAAALSSLGSLFWITILVHRQRATQSAYADLGLQVPSVLSLQKITNAALEYVVAVWQPLFHLGIGLLVRSMLDTRESLVALSALKYRFEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RND9</accession>
    <name>A0A088RND9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_200900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698289.1">
        <property type="nucleotide sequence ID" value="XM_010699987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RND9"/>
    <dbReference type="GeneID" id="22574297"/>
    <dbReference type="KEGG" id="lpan:LPMP_200900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200013500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_200900"/>
    <dbReference type="eggNOG" id="ENOG502QQ9T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275256at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19851">
        <property type="entry name" value="OS02G0203500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19851:SF12">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="546" mass="59283" checksum="3E857B145A99FC3F" modified="2014-11-26" version="1">MPKEPQFSRPYASSSAPYAKPSSSLVPAASLSTGATAATRALTAGTAAGGGGAAPTVGGNRPARLTVNNFTAFHARVKRLPPDANVKAALHTQLYQFPERVCFGCVKCRRDNVESDSVAIDLKNRIMLCTACFTRIIRPRTYTPSRVIPFPSLLSWLNYKPSHVMKMSDDVLERPAEAVAPSGERMAAPKLTGGDRATDLGKLPAIAMNIAAGGRGRGSDTTGGRHGGPTIDEVLAQGSDDTPTGTHPCLRVWGVCQHGETCLFRNAPADLCLAYLMGLCRGRNMPISGTPAGDGRGSGPNANRSNNRHIYGGQHHHHPKHNQRNNQGARNTRRNRNTHPTVCGQTCHLLHQEVYDLPDLSDPPPRERFEGDLEDENGAWAAWVRRRRDSPNSAEWQVWHNGPLEQLFRTYVPARRRPAPRQPKKRSKVAPEATSAVEAKSVEERKRNAEGEEGAQTADEELTTLVADEEDIMDGEENEEGEEEDDCDDDANDDATSEGAVHKEAEDEPTPVPAPASATKLNLMDIMSALKGIKRDTPEKADEAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNQ5</accession>
    <name>A0A088RNQ5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_200910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698290.1">
        <property type="nucleotide sequence ID" value="XM_010699988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNQ5"/>
    <dbReference type="GeneID" id="22574298"/>
    <dbReference type="KEGG" id="lpan:LPMP_200910"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200013600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_200910"/>
    <dbReference type="eggNOG" id="ENOG502QVR6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="243988at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="924" mass="99479" checksum="E6F67DFBE44E46DA" modified="2014-11-26" version="1">MPTLVRVADVSESRLFSSATSHGAPEDAGDSGRCVISGAVSPALARELSLLSNEDLVQRIHRFSRSNFVPSQRPLLYAHLKEFMKPKRLMYASTKTVQDHLQVANAADMHETCIELYHAAREHMSAAALSLRPPCASLTHSSVTGVGQLDASVHVGLSMASNSVTNLATDGAVLVSAFVVDSAYATQRTSELTRLASYCVTQLLAPLHAQGHGGTTGDTSAAAGKVLRALAVRTPREVATELSLVRCLWRALCLAEYYKCAEATGTRTVKGNTEQALADALTILDACRPVASMRREAAVAVLTAAATGDPSCYEHSAIATTTPTLSPRQSSELLGVALNFVRYASLDDDGEFAFYQFCKEERILWSPQPLLWSAQGEASNATSSLSSAAATGGVSAFAYSEDEVQVFYAALIDTCAAGRLVSEALLYFTEARRLLGCPPLADGEDTGAEAVLRRGAGGGSGSQIGCAAATFTAKKPSEAVNAAPAPLAASFPSSDVGISPLLSSQSHPVTISSGAYRDNASARAITVGFSLTELLLHRLLSMLQTAKENHHVVRLARALIAAGAVSQVKAHIWTPLLISAGAARAADVVLTVYSYVLERLTSPACSGGSSGSGCTTAERYTLEYLLQTSLNALSKCQLPRYEQDYLQPARERQVLHCTDEFYYSCLLQEAHNSMCPAQRAAEVLARMEETKVPMTAPIVSRLLKLYLRVEAPEFITVYRHAVNDLGLPLRSVWADQLLLWADRRRYFLSADDRAYVLQQLLCSRRVTTVTDLQPLLGGFRTHFALLYHDHTHAAREQFLSDGSVPGEQPTVMDSRAHFLITRPMSVQRGVMARSGTSWVCTGAGGEEMAEDEAEQHGILPRMLGDAPRRTLYASIAELSETALLFPFSPSARSSGDSERLHDMALRVYLADVLDGLQRSSNWVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNS8</accession>
    <name>A0A088RNS8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_200030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698202.1">
        <property type="nucleotide sequence ID" value="XM_010699900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNS8"/>
    <dbReference type="GeneID" id="22574210"/>
    <dbReference type="KEGG" id="lpan:LPMP_200030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200006700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_200030"/>
    <dbReference type="eggNOG" id="KOG0299">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="189968at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001734">
        <property type="entry name" value="WD domain, G-beta repeat, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039241">
        <property type="entry name" value="Rrp9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="272"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="464"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="438"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="503"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="451"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN97495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="758" mass="81560" checksum="53F6F97AC910737C" modified="2014-11-26" version="1">MLSKQKAAKRAAISATVRREHQAREKLTRPDTQLHTSRNKAAATASTSSRDVDDFKKRKSRTVLRSTDETEASSGAGSRADTIRSLGDHINTRLQEVAFEDDLDGDVFHERRAQLMEEARLAAGVQQRDVSTSVRHYLGHRTEMRDLDSMRIAHNCNSITCVAALGMDRIVYGDKSGKVYLTDVSLATSGVGMAVSDKAELQRRRKVLLEPALPSGIVSIAISDTTANRPTARDVFEKTTVDMSCPSYVAAGAMDGCISVWETFTRAHKGLLFMHRKPITGLRFRMDTAVLYSCCEDGTLRVWVVPQMIAVDKLFGHEGPIHFLDCLRKETAVTVGEDGTMRFWKMDAATQQAYSYAPPRLPEKSATADAAVSSPAPPPSVVMDAVAMLNESIIVAGARDGTVVVFDVNRRKPLVVVPAAHGCGFIGDGTGLEKAAAELAEEDGRERLARGHATASSSASGEATRRTPNPITAVAAVPYADLVATASYDGVVRVWHVVGVGAGATAPGKRTDDNRNSDSAPSSGKWAAEPQLVPVVELPVRAIVNALHFSDNGNVLIITMSKEPRRGRWVVQSSARNGVLVVPLTESGRQRLQGVRGEIEHIPAQLFGIDAAEEEDATREEEEEAHADVLGAAEAELNSSGELHANDSKTSFGREDGEEVADMFDVGPDGMMRFREGVSLAGGAVVASKRRKAKSGIPKVLRQTKELVDVTVARNSGSNTKKVLSAKKVKCVAAKSKRLHVSDTALAVSKKAMKKANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNW0</accession>
    <name>A0A088RNW0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_200280</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698227.1">
        <property type="nucleotide sequence ID" value="XM_010699925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNW0"/>
    <dbReference type="GeneID" id="22574235"/>
    <dbReference type="KEGG" id="lpan:LPMP_200280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150012200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_200280"/>
    <dbReference type="eggNOG" id="KOG1989">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967:SF57">
        <property type="entry name" value="AUXILIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="39"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIN97520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="340" mass="38424" checksum="A71DE1C85AA9CE3F" modified="2014-11-26" version="1">MGNYFSLCPQAVHGVLSFNGIGAFSSAHPTGVVVRGVDYSAVKLIGEGGYAFVYEGYNNATGQRVALKRYVFTEMQQQQVVVNEMNIYRDVCPNDYIVTYLDSEMLYRAGLPLPEMWVVMEFCDGPSLQEYINNRLQSPHPFSAREVFEIVDNLLHAIGHLHSQSPPVSHWDIKPDNFLFTETGRLKLCDFGSATRMFYAPKSVEEVSVAESELGSRMTLLYRPPESLDLWSKDRVDTKADIWALGVIIYVLVFREMPFEANSMEIMAGVPKRYKGNAEDSCPEDFRPLMNVVRTKMLTKKPADRADIFSISEELESITHLPPLSRPRPGLQSAQRSRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPG0</accession>
    <name>A0A088RPG0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">META domain-containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">META2</name>
        <name evidence="3" type="ORF">LPMP_170860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697777.1">
        <property type="nucleotide sequence ID" value="XM_010699475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPG0"/>
    <dbReference type="GeneID" id="22573829"/>
    <dbReference type="KEGG" id="lpan:LPMP_170860"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170014400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_170860"/>
    <dbReference type="eggNOG" id="ENOG502S0KY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269925at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015232">
        <property type="entry name" value="DUF1935"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005184">
        <property type="entry name" value="DUF306_Meta_HslJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038670">
        <property type="entry name" value="HslJ-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036310">
        <property type="entry name" value="Smp-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47047:SF8">
        <property type="entry name" value="CYSTEINE PEPTIDASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47047">
        <property type="entry name" value="PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09149">
        <property type="entry name" value="DUF1935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03724">
        <property type="entry name" value="META"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101601">
        <property type="entry name" value="Smp-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF306" evidence="1">
        <location>
            <begin position="9"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="DUF306" evidence="1">
        <location>
            <begin position="118"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="DUF306" evidence="1">
        <location>
            <begin position="227"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1935" evidence="2">
        <location>
            <begin position="340"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="444" mass="48411" checksum="BC93594AF7F5B3DA" modified="2014-11-26" version="1">MSTADDICGTYTLSHCDGRIASTKATLTIHRCGDTLTAHVTVVNDLRGTVQYENGHIVGSLHSTGNVTGPAQESVEQMLSKGFADGFDIVIELNRLLLKNTNSSFAFVCSSKLSDLNGEHAIIAINGQPPNQEMIMRFIPDGNGGCFVTANVANSLRGSCQLDAGLLRGELATTQVEADESLMRVEKLISEGFQKGFHICNNESGILLQSSEGTIQLCRILSQINLEGVYVLKSFNGGAVPTRNQPIVTFRPGNANEVDISISVANRIRGTAALNQNVLSSEEPLMSTRMMGTEEESKLESAFNVGFQYGLECISSGNELTLKNQDCKFVLVKAAIPEAQHGGSSYKGTYCSKCFKTEGNGLLFRLVNDHEKKWAFYNDTQDFRIHVRATFGARSNIEALDNASMYQNDDGRYIVEVTVNPQSTEMFIEGDVNGFRAHYDAEPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPK4</accession>
    <name>A0A088RPK4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Defective in cullin neddylation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_204040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.</text>
    </comment>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698605.1">
        <property type="nucleotide sequence ID" value="XM_010700303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPK4"/>
    <dbReference type="GeneID" id="22574615"/>
    <dbReference type="KEGG" id="lpan:LPMP_204040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200046500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_204040"/>
    <dbReference type="eggNOG" id="KOG3077">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="286637at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.200">
        <property type="entry name" value="Cullin, PONY binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014764">
        <property type="entry name" value="DCN-prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042460">
        <property type="entry name" value="DCN1-like_PONY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005176">
        <property type="entry name" value="PONY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281:SF34">
        <property type="entry name" value="DEFECTIVE IN CULLIN NEDDYLATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281">
        <property type="entry name" value="RP42 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03556">
        <property type="entry name" value="Cullin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51229">
        <property type="entry name" value="DCUN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DCUN1" evidence="3">
        <location>
            <begin position="46"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU410713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN97898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="244" mass="27257" checksum="47B492D3377064BC" modified="2014-11-26" version="1">MKNASRTKASVSLMRDRNLSNSSVPAATRPTGPAAKGAVTLFVSKSARSDMELVFDRLHALDKSTQSDTISGKGLAQFFCEVSVEASSLECMVLLWKLGATQQGCITRPEWLLSMYANGIESVAQLRQKLGEWVKDVRESSGAFLLMYTYMYDYIRGEEDRRMTRTTAINGWDVFFGQNKRYAKWKTWAVANLTGDVSRDLWRQLGIFLTMDTDATQSSDDQVLALSWPSAIADFMETDNLPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPQ7</accession>
    <name>A0A088RPQ7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_180180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697852.1">
        <property type="nucleotide sequence ID" value="XM_010699550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPQ7"/>
    <dbReference type="GeneID" id="22573908"/>
    <dbReference type="KEGG" id="lpan:LPMP_180180"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180006800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_180180"/>
    <dbReference type="eggNOG" id="KOG0145">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266020at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000707">
        <property type="entry name" value="RNA binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15241:SF304">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15241">
        <property type="entry name" value="TRANSFORMER-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="24"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="117"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="342" mass="37045" checksum="1D72E4E25125FAD0" modified="2014-11-26" version="1">MSYKYNGAYNRGRPSVTTATDSKLNLLVRFLDHTVDDVQFRVFFEPFGDITSSMVMRDIFTGESRGFGFVRFARNADATRALHECDGKKIGGKAVNVIWAKQQHDDTPAGQERLRMNKLFLRNVPLGITEAELVELVRAYGTVKEASLHSDRIPTARHSPARRIAFIVFADEGAAEAALRGVHNTCPFATCHGIPLMGKLSEDYKAKNSGSGNSSTNSSCQNFSTASRAPTTFFTDQGCLPPMLDCAFCNFVPKHVTGACTPTPASSVHLSDSAADDLLFSPLAVGAGASHADGGIAEQDAIARYSPALRLSTLRTPVLSSPKLFRHNPYAASLIVPRSNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQ67</accession>
    <name>A0A088RQ67_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Methionine aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_190520</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with zinc, cobalt, manganese or divalent iron ions. Has high activity with zinc; zinc cofactor is transferred into the active site region by the ZNG1 zinc chaperone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Associates with the 60S ribosomal subunit of the 80S translational complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="11"/>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698047.1">
        <property type="nucleotide sequence ID" value="XM_010699745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQ67"/>
    <dbReference type="GeneID" id="22574106"/>
    <dbReference type="KEGG" id="lpan:LPMP_190520"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190013500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_190520"/>
    <dbReference type="eggNOG" id="KOG2738">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3209743at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000010">
        <property type="entry name" value="Methionine aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031615">
        <property type="entry name" value="Zfn-C6H2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF7">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15801">
        <property type="entry name" value="zf-C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52013">
        <property type="entry name" value="ZF_C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C6H2-type" evidence="12">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIN97394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="401" mass="44798" checksum="2E87E6139E7BD044" modified="2014-11-26" version="1">MPCEGCGSSEAGLQCPTCKKLSLPPSFFCRQDCFKTHWGTHKLKHTDTRNLPATIPTMTEVDERLFNFTGPLRPGRITPRRAVPKEIARPDYADRNDGVSELEEKDSGSNRVIAHSLKSLHEDYNNTELRRGSDILKIKRVNALSREVLDIACAAVKTGITTDEIDRIVHEATIERGMYPSPLNYYNFPKSVCTSVNEIICHGIPDNRPLEEGDIVNIDVSCYLDGFHGDLNETVFVGKPDDESVKIVHTAYACLMAGISVVKPDELYRYVGDAIEARAEKSGCSVVRSYTGHGIGKCFHTAPNVCHYKDNKSSGLMKPGHVFTIEPMINLGTWQDVTWPDNWTSATKDGKRTAQFEHTIVCTPEGVELLTDWKDGIPFYQKQLKEWSIPIPAEDPTEVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQL0</accession>
    <name>A0A088RQL0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_221190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699119.1">
        <property type="nucleotide sequence ID" value="XM_010700817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQL0"/>
    <dbReference type="GeneID" id="22575165"/>
    <dbReference type="KEGG" id="lpan:LPMP_221190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220015300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_221190"/>
    <dbReference type="eggNOG" id="ENOG502SKV7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267876at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="185"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="253"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="631"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="186"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1153" mass="123558" checksum="A31B3B93CDAA100B" modified="2014-11-26" version="1">MSHESCGHARSVETDRMRELKACDRMRRACPSAPPLRLWGKVPVSVGTSIENYCTSLPLSVSDASARRPSSPTTTSVPPFVCGDAMLHPRADAVRAPASEGQLEGRGITDSFTFQPESFESASPVGEDEVHAVTDKGTSMEELSWNAVAHRRYSTSASFAVQTPTAAPLCTATVAVPAGVRTHHASAVEEARRGDSEPTRTHLHGPWMTPSTFPSPAVAEPLQLVVPPPPTPLSAVSHSTVPSSLALAIPPQHTREEGDAHLRGEPLPSSSSPSPSPSHPRQVYQATPVRGHSRTQRVEDVQGTNASSPIAVCVSGTPPVPLTSAFAIAAEQNDRRTCEDEAREMTSTSGEVVGERGDCCPAAKSRTPLPARVLQDGANNGHLVTSAVADVSAESSTTPDGRRGRLADTLQPEASAYSFSPPPSSIVRSSCGIVRILQLQDQEGWQDRLRVALQQDAEVWVRQVCEEQRLLQAQLSVAQARAAALAKSLQVLYDRGWSSAPSLRPPSQPMDSAGVPISGASEKRCEERVTAERPCIDGINCKARVPHLAEYSLKKSAVREDSSEGVYTSSAADDATAAAFGTAYTHKLEAYIRLLEQHTHTLHSDKHQLQLRLDRQTSQLAMLQQYYQHHYARLLQEQSALERDSRKATEDVEELVGMLVVTRAAERAAMRRAEEFELALEKSELRAETLAAALHPQVKGNHRCDTEGSIGTITPISETIVVGPHRCESLHCTSGYASGPLPSSAFASFVEHDDTERSIMEMDALTAAEAASRTSSVERRRVLAGRSTSASSSMCPPLPPGASSLTVESPGWTPMQALTTSIGPECSCDVEHTWGRTGSSLSAVQLSVTPSAMRIAAEVESNDAGDVCSPEVCVAAKLVSRDEGIVSQPPCAPWQAVTAPPTLAPLPNADAIAIVSTAAMASHGSASSRKLSCEVNSDGAFASTALTAAPVPAEREEARNASVSVTMSLTSSSTSVFTPPTPTATTLLTPRSLARRRRHVQHQIKALRDDTEEGNASDAADEYQLLRLRCTLLELELQAKEAAHRAEKEAWETAVHHAEGIRGAMGEVEARVSQAAAASERAKELLREMSQLWSNSLALDEDDVIDDDSEGAAGATGLLMMDKGQAFSPHRSHNWTPLHWRDLEEPSPFRLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQN4</accession>
    <name>A0A088RQN4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_200470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97539.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698246.1">
        <property type="nucleotide sequence ID" value="XM_010699944.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22574254"/>
    <dbReference type="KEGG" id="lpan:LPMP_200470"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_070014200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200008400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200008500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_200470"/>
    <dbReference type="eggNOG" id="ENOG502SH95">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="263823at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40738">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40738:SF1">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97539.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2424" mass="255273" checksum="20E05D44603FEB8A" modified="2026-01-28" version="2">MRGEPMRTGERLALPVGIVTTTLLLLSTLGSMAAAGPVTTNPVQPLLDIPFFATGTALSVGSKLFISSDATCTKSLSTTCSVKSEVSGSSFGNGTCIFTVGSAALEVKLTSPRTSVPAAYWCVGSPGSAKEVATLQMHKMEVTPEYVFNSEESVLTFGSAVPVGTTVGFYADDLCRLLHAGGGPFMIAKERTVKLTTKLSSSSLFICASTFTVNGSTTRVTLVNTVLLANPYTVNPATGVRHQTIAVSSSTQPYAQFYLSTRAHCADPRPVFQSSIAGQMIMKVDVPRGEYLFCGSLLASENGVYIPATNTFTVLEYDVVPRTLYIGKVTDMSFALDAVPVQSALEAVLSTSEDCTAASSWQNTWGNPMQWSAKLLGVHYACVRRKDNTAAVGYASVIIATDPPTTTFAPATPVRGVSLRVTLTHVNATKAFFIVGLFASPDCKTLLVRGTASPATSASASLAVPLTAPDSLHYCVSNPLNSDPAMQDEVVRYHKLETLAPQPFALQHAPLRVGAPSTITLDSTVHLAKGTTVALVRADASKPPCEATDMPTLDVAGAAFVLGPITFPEAGTWDVCVREPGADYLAVQRVTVYGNATVTPRGVVAGVEGAIVVRGLPPGAAVFVTSAPQCTSDAIVLGRATTSAEGAATLTLRCDSVGTLLLCCDYPSTALQPVLQAAGSVRSASPRVAPAVVSLTAQTNGPQLLSFVAAGAAVLDGHAAYLLPGKSACPSGTATPGAAIVLPALKVATDSDTPRASLELRAAMVGTRYLACVNINGSFVATGTVSVVLPAPRLASDPAPLVAGLPATIRLLGTYASAAQVDTYAVVRGDVDCTTDLDTKAVLARGSIDPHTGVTTPCLVPQDASLLTRLRVCVAPRHSLLGGAGAIGYAAAGELDVIAFGPLSPYAQLRRPASEVTGWPVHTAATQHLVRCSTATDDCLATPAGASAACAAAATRYSVGGTTQGDLFAPRGSYLLCQSATLDGVMGTVAANATVGVVDAFAMTTDADLKRIRSYVPFGANINGGPMATTFYSVVVQPASVPCSIVVNESQTFTSSESSIIINISDIEPHIDVHFCAGPTTTSSRIEAMRATLHHYMSPAYIFADTLTTIALPAQSAGTSALLSSSRSLPLPVQGGSRRPLSGNRVSFTVDGCGENENITELFYHEFNGAWSAPRGRMLLIRTSSCRGGAGAVNIRTVDAAPGTPISDAGIDTRFLAIAGIGTSNSSASLPGIGVLSTGYAPAMGEYAAFHVWAHPIGDPHALFTTATATLRVRNWAVTPAYALSRYNATVGAAPHTLLHINDATPPGCTFFSQSQRCDNSLGDAAEMGTSTQAAVYSATGVSGPVYVCTCHPQTGAPLAVASFTSLLLPQVLQASPAIVRGANYIATLQAKGYTLQTTSTFLSHDHCVGSLPLQPTGASTAAVVSVSFGTASIAQKVEKVSLCVRTPAGTGAAIANVPVASGSMWPTQFAVGATGATIFMPLSPRTTFQLSATATGCTDVSGMPTFSTDAEGYGTLSLLRANDDALPLGYYAVCASTPTRAAAALEVIEVVPAAHFDVRGTIFVLGVPSRMELQQDLRTADLIAGFSTTAACSPITTDHGTWAALSSTAIEVRATAVSSTGVFLCAQVPANGTVVALPHSSASPGPITFVQLAMALPTGSWDTCTDYLVNQCYPPGSAGSTAADVLTVVHGDCCDRTAQAQAVGSASMASGICRLRLDAAKVAAYATDTSFGVCAWNPNKSSACATLRRVTVTTNCTPSKVGRGARMSSGAVAGIVMACTASSVALLVCAVWLACRLCGAKKRNNDTQSDEESPSFGDTADTAGATEQRQRLGPLWNPLDNVAKDVMLSGRGGGEGVASAKWFTPTIPLSSSRVTAGSVEAPQDGTPNCMDDLPDVITKYYSFLDDSDFDYETVSQIPGEGEPSTMDEELEAMLAVPRASALPEELEAKRRAELRVVADRNATLLAVREERHRMEEEDPVKLKGILLQEREEWTRAALESRYRRADYNLTVLFKSSLEYNNALWRRRWGELSESPSDESELLSVGSWDVAPLAPLDYERDRCMDARLSPSKSHASVYSPTASFQYSISKSPVLQKPQLLTTGLPPARSWSAGSQSSAAETQPSPCSPNDLYHRRRFLEFPFVTNSLQTLIGGDKNLPEPVFLRGLTLIDLQAFHPKHRWLVDPPQPSHSANLLPERKGMWAFMAPGSTVPFVRRYLTLLEEEFRGRRRALQANATFWKRVFWEKRNVPVFSTVEEVQPVYNFDDARSFCTTSLEYRNLSSSENSSDGEGTGNKGTRRRQTTEELWAKEKVASASIVERRRVEQELASLTITKNMNKREKKKIEAAQAAFRAAQSAERKARAAEEKAEAARLKAEAANKDAKTAKAGCERRSLSRTRPTSPTPVGELAGQEFQRMEELRRLGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRF0</accession>
    <name>A0A088RRF0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATPase domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_240170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98652.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699359.1">
        <property type="nucleotide sequence ID" value="XM_010701057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRF0"/>
    <dbReference type="GeneID" id="22575426"/>
    <dbReference type="KEGG" id="lpan:LPMP_240170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240006500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_240170"/>
    <dbReference type="eggNOG" id="KOG0730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003013">
        <property type="entry name" value="ATPase domain protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF196">
        <property type="entry name" value="ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98652.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="562" mass="60708" checksum="D4D39631F9E48A45" modified="2026-01-28" version="2">MLCPHFRLSCACFRATERVDDYLPLLSMSVDGHLIADVQRLRQLGEQSLFFLLVGSKGAGKSTALQSFVSGLSVTTKVRHAAGVHDIILTAPAAASPDDDFTLWTLTYAAVAHSSSSLGVIATHALSLRPFSIVVVDDIDLLWLLCSINGLLPLLQRLLQAALTSSSCVIVASAPSQDTVPAWLLEQRLPALYPLRELTEAGMRRLLRSVPQPLFKSHVELLSGAQTLSTSRQMLLFNACMTLEAAAHGVTGENLRSLARENCAFLHHRRSPAVSQWAPPHLYGLSEARHRISTLVSVFTAHSSPGGGDRLLASLLSSTGLLLHGPSGCGKSSLARQLASDFPSMPFFFVECTRLFSKYLGESEEQLRDVYRRARARTPAVVVLEDLDAIAQSRGVMRCGDSDQGTGNGKGQLDVTRRMLAGLLCELDGVIGNSGVLTIGITNAPQVLDAAVLRQGRLETLVYIPPLTHDGAEELCAHFFQRFDGAEGQRRECAMVVANHAVGCAPASLQYVLRKVFEASALRHGWDSASAGSLPLPTIAAIQGHLFESCSILQRVNHLHFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRM0</accession>
    <name>A0A088RRM0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_241140</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phage and mitochondrial RNA polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2"/>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699454.1">
        <property type="nucleotide sequence ID" value="XM_010701152.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22575523"/>
    <dbReference type="KEGG" id="lpan:LPMP_241140"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240017600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_241140"/>
    <dbReference type="eggNOG" id="KOG1038">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276422at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034245">
        <property type="term" value="C:mitochondrial DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006390">
        <property type="term" value="P:mitochondrial transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.280:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000082">
        <property type="entry name" value="DNA-directed RNA polymerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046950">
        <property type="entry name" value="DNA-dir_Rpol_C_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002092">
        <property type="entry name" value="DNA-dir_Rpol_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00940">
        <property type="entry name" value="RNA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00489">
        <property type="entry name" value="RNA_POL_PHAGE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase C-terminal" evidence="10">
        <location>
            <begin position="892"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN98747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1299" mass="145561" checksum="F3C395E778B85031" modified="2014-11-26" version="1">MREVGSHLAKDEAENATAVEGAGEDDDDGIAFCEVASAAELFAMDEVKLNAAEMSHAGTTKSTHDHAGKVGATERGSTLSAFALPANHGSSGNGSAAADVAESLLSDPFHVPSVDDDAFARDGDLPASAAASYSAVTNCQNLNENVLSAVDVLCDDLFHCKASVLHSFARTRSITSRNKVEVVLRLLEQAHRDAHGESNDLRVTRRLLGDVFDENIRTSGLRTAWTNKSLEAAHIEEACESHLSFDLLANSTKSLMVRRHAGEISRVLRKLTRVFQQEQEQISLAAVGGVFRNYRAVAEELVRELPVCEVLSPFAGYLVSYVRYGAVKEMLARADVNERLVQLGVIHPTVQEVDDSALLHRLMDLLDPAVHQVERRAECFRHAEQSRVVGMENGDVIASTIRAFSEVSHTKWNTHAAPDWVHDLARLFCSWEMILRTDLPRFEEVPRHFFDCILSGVVCLYIAQRVYGNSVGTTVVPLYQRMAIKKSLRLHFNNDDNTDSALRDIMSYVQAGATEARGGVRGEFFAGVLSQMQGAFQDAQEERSTLHEERVAVILNAVCDVATNCTRSAGLFNLLVKLTEDLAFHFRFQHIYRKLSAPDRVTIRTNGSIRMSQTLEYFEKELHVTPISTKAVGFLVVQLLYLSFRGDGSKRPVLERFASVTGATELDMVGLTEMAATSVRDLHVAFPPQLSYNSWLNESDTREKSVYGVLPSVAVKGAANQAMIVSQAPMMKALDAISRVPWRINKYMLHVQEAIVREGFGFGKIRPGFYPLHYYSMSDGDIKYPSDRRRSALLNSNDNDGDDLAAGDVFNLQQRRQCTLQQRQDWKELCELRSSRIHYLLGLRQARSIVQFSHIYFPNSMDFRGRMYPLPGRLNHTGSDPFRGLLEYAEPKPLGEVGLYWLKVHLANKMGMSKLSFDERVHYVDEHMEDVVQSAENPLAGDRWWQEASEPIQCLMACKEVADAAKCSQGAEKFLSRLPVAVDGSYNGLQHYSAIGRDAFGAKLVNLVPSERPADAYTGILKEMLKSICIDADRDHQVAQRCLGTGRGQDKDHIKRKTIKRPIMTQVYGVTSYGMSEQILDELVKQNKSHGLWTHTDMKEMAAYLRDKVLESLGVTFRETQNCRRWISEVAALLWKVQPAELRNALCWTTPLGLVVRQPYKVRNECSLFTPHGYSRVPGDSVAPASRKQLTAIAPNLIHSLDATHLAMTALEMQHQGLSMMAVHDSYWTYACDMPKLSQVLREQFVNLYSKYDPLWELKEQWEETYFMDLRRHGVKLPDPPKRGDLDLNVVLNSPYFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRU2</accession>
    <name>A0A088RRU2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TFIIH basal transcription factor subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_204650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698666.1">
        <property type="nucleotide sequence ID" value="XM_010700364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRU2"/>
    <dbReference type="GeneID" id="22574677"/>
    <dbReference type="KEGG" id="lpan:LPMP_204650"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200053200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_204650"/>
    <dbReference type="eggNOG" id="ENOG502S04X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277424at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="593" mass="64029" checksum="CD5D7FDFA512DB91" modified="2014-11-26" version="1">MSELQLILSPAQLTKHYELLQFLSRHPNQPYTLAQLDSLLPRGVALQGFPKEWFSLIEDGACWHRSIELHRNYSATASTAAARLNTGAAQDGPSASSPLGFNSTAAERAKYVLLCARAEVNTLDELRKRIDSPSTLLDPEGCVALHTDQIVISTALIRRAVRTGLVHYFPDAYDKAEYKHLGMRDASSSASGGAAAGSGPEGRTGNSGGSSRANVGQATSSLLESFLERDEAHGEGRNGGGDRIYVALPPGVCVHHRLLTRRGVPEQEAYSLPTRFYVGERVQILFDNQVAVKKLGLPNELRVDWSLAGVKLPNTGDTRQTTGEGGTSRLEALAAAPPPPLRVRRENLAVHSTPAVANASPSAVTEASAAADAPAPIVISTKVKMEIEAVQACLVKLILTVNGVENVLNLEVREEAVSLPGVLVLRDRHLDSFSLPEKSVLADPIVNPSPSWQYPYESVLRAACSSLPSNSRDDIAAQWASAAAEPWSELVPLPWTQNPSPAVLALREATYPAQDATVRAATRAVFSAQSLADEARLRQTKARVRFEADARAGSGSGGKRRRRQQLRSNVMLSNRHLLHFGLDFSIPFVNLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RS64</accession>
    <name>A0A088RS64_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA ligase (ATP)</fullName>
            <ecNumber evidence="1">6.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">REL2</name>
        <name evidence="6" type="ORF">LPMP_205830</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + (ribonucleotide)n-3'-hydroxyl + 5'-phospho-(ribonucleotide)m = (ribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.5.1.3" evidence="1"/>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN98074.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698781.1">
        <property type="nucleotide sequence ID" value="XM_010700479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RS64"/>
    <dbReference type="SMR" id="A0A088RS64"/>
    <dbReference type="GeneID" id="22574795"/>
    <dbReference type="KEGG" id="lpan:LPMP_205830"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200065600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_205830"/>
    <dbReference type="eggNOG" id="ENOG502RW2V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6142248at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003972">
        <property type="term" value="F:RNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1810">
        <property type="entry name" value="RNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012647">
        <property type="entry name" value="RNA_lig_RNL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021122">
        <property type="entry name" value="RNA_ligase_dom_REL/Rnl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041948">
        <property type="entry name" value="Rnl1/2_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040609">
        <property type="entry name" value="Rnl2_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02307">
        <property type="entry name" value="RNA_lig_RNL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09414">
        <property type="entry name" value="RNA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18043">
        <property type="entry name" value="T4_Rnl2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN98074.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="418" mass="47717" checksum="D0395DD83660B5CD" modified="2026-01-28" version="2">MLRRCLLAQLVRRSPILFSGEREALFERYSEIENAHSRRIEALKNAGLFNDEWIATEKVHGANFGIYSTEHGKTLQYAKRSGIMPPHEHFFGYHILIPDLARYAQKGRELLMERLGSSPSTVIINGELFGGKYDHPSVPKRRQSVMVAGRPRTITAVQNNAFPQYCPDLHFYAFDIKYRMTEEEDYYTMTYDEALAIFEKIPGLLYAKAIIRGPLSKVTAFDVENFVTTIPPLVGMGDYPLKGNWSEGLVVKHRRRGEPGFDPKGLTIMKLKCTAFQEISTDRRQGPRVDEMEEVRQQSIQVSGVQLPDMESVIREPEVCQATQHLLSHVCENRLQSVLSKIGTDPFETQSMTPNELSTLLAKDALKDFLKEVDAKIINAPLLIRREMTRYVLFEARKYVASRWKDILGQQKNADGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RS95</accession>
    <name>A0A088RS95_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_242110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699550.1">
        <property type="nucleotide sequence ID" value="XM_010701248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RS95"/>
    <dbReference type="GeneID" id="22575620"/>
    <dbReference type="KEGG" id="lpan:LPMP_242110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240028400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_242110"/>
    <dbReference type="eggNOG" id="ENOG502S548">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="47801at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="CDD" id="cd00195">
        <property type="entry name" value="UBCc_UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="102"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="321" mass="35958" checksum="B88C633C45253ED8" modified="2014-11-26" version="1">MASPFPSSHEHSTTTRDYLFRTLYLRREMLLLATHGTASEITSTTKGKDEEQPSPATSVEPASSTRQDVLLLPPLYSLDGLSLTPSASDESAFGEDPMLKQDHAWNGLVHVRSSSSPWHRGCFAFYVYFPSRYPFEPPIIELAGPLRSHPLLQERCLQCLGQRSGAAGHPLGIPSCDSAVTTTRSAPARRVFVPFEEVYATIDPMRVSVMSVLIRHMHLIFHPAEWPVSWRPPSMEADPTAHDSSTVNHILARRDVERRSVTQEVLLLKPFEQYVGTEVMEHFLNVWEASEGDAGDDVTDTVTVDEADWYTREVLPHLLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSJ3</accession>
    <name>A0A088RSJ3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-directed RNA polymerase I subunit, putative</fullName>
            <ecNumber evidence="3">2.7.7.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_250150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.6" evidence="3"/>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699587.1">
        <property type="nucleotide sequence ID" value="XM_010701285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSJ3"/>
    <dbReference type="GeneID" id="22575663"/>
    <dbReference type="KEGG" id="lpan:LPMP_250150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250006600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_250150"/>
    <dbReference type="eggNOG" id="ENOG502S3YG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="259769at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.940.10:FF:000007">
        <property type="entry name" value="DNA-directed RNA polymerase subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020708">
        <property type="entry name" value="DNA-dir_RNA_polK_14-18kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227:SF3">
        <property type="entry name" value="RNA POLYMERASE SUBUNIT, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="RPB6/omega subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01111">
        <property type="entry name" value="RNA_POL_K_14KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="129" mass="14237" checksum="8C78F512F6D56F6F" modified="2014-11-26" version="1">MLRSEVLDAEVAKSVGAHSAAVTPFAERRSGLYLTKFEVARIIGERAKQITSGAAMSLPGTTTGLDSVEIAERCTNPRSLAVDPVMMAKYDLLQRKIRMLVRRTWPDGVVETIPVNELMVDVTMLNLQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSN4</accession>
    <name>A0A088RSN4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_250550</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699627.1">
        <property type="nucleotide sequence ID" value="XM_010701325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSN4"/>
    <dbReference type="GeneID" id="22575703"/>
    <dbReference type="KEGG" id="lpan:LPMP_250550"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250010300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_250550"/>
    <dbReference type="eggNOG" id="KOG1073">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21539at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01736">
        <property type="entry name" value="LSm14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025762">
        <property type="entry name" value="DFDF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019050">
        <property type="entry name" value="FDF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025761">
        <property type="entry name" value="FFD_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025609">
        <property type="entry name" value="Lsm14-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025768">
        <property type="entry name" value="TFG_box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586">
        <property type="entry name" value="SCD6 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586:SF0">
        <property type="entry name" value="TRAILER HITCH, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12701">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01271">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51512">
        <property type="entry name" value="DFDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51513">
        <property type="entry name" value="FFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51536">
        <property type="entry name" value="TFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="7">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="DFDF" evidence="4">
        <location>
            <begin position="196"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="FFD box profile" evidence="5">
        <location>
            <begin position="236"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="TFG box profile" evidence="6">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="96"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="264"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="FFD box" evidence="1">
        <location>
            <begin position="236"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="TFG box" evidence="2">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="183"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="280"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN98920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="294" mass="31988" checksum="DBBD39AC17B6D454" modified="2014-11-26" version="1">MHNAVGDRINLISKSEIRYEGHLHSINTDENTVSLSNVRIYGTEGRKGGGVDEVPSTEQLFEFIVFRGSDIKDLTVFRDGGSPQARDPAIVEVHAPSRGRGGRAAAAAAPAGASGATSSAAARGSRSFYDEHSSYSRGGGGARRGGYGAGRYSHNNGGGNSSGNRNHRGGYGGRGGSGSYRRNYRDCHTGQDFKPSDIGATEKFEGDFDFAKCREEFEKKKSEFEKAKEDAKSHAKAYDKSSFFDTISCDQKEKNNMNRAEMRKADTETFGSEMVSSMRGFRRGRGGRGRYQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSQ3</accession>
    <name>A0A088RSQ3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding nuclear protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_251450</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the small GTPase superfamily. Ran family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699715.1">
        <property type="nucleotide sequence ID" value="XM_010701413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSQ3"/>
    <dbReference type="SMR" id="A0A088RSQ3"/>
    <dbReference type="GeneID" id="22575793"/>
    <dbReference type="KEGG" id="lpan:LPMP_251450"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250020200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_251450"/>
    <dbReference type="eggNOG" id="KOG0096">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="48625at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00877">
        <property type="entry name" value="Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002002">
        <property type="entry name" value="GTP-binding nuclear protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002041">
        <property type="entry name" value="Ran_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071:SF0">
        <property type="entry name" value="GTP-BINDING NUCLEAR PROTEIN RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071">
        <property type="entry name" value="RAN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00627">
        <property type="entry name" value="GTPRANTC4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51418">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN99008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="216" mass="24240" checksum="674D20E2ADA3908A" modified="2014-11-26" version="1">MQQTPSDCVASFKLILVGDGGTGKTTFVKRHLTGEFEKRYVATVGVDVHPLTFHTNRGKICFNCWDTAGQEKFGGLRDGYYVEGQCAIIMFDVTSRNTYKNVPNWYRDITRVCDNIPIVLVGNKVDCADRQVKAKMITFHRKKGLQYYDISAKSNYNFEKPFVWLAKKLANDPDLMLVEVPMLDTDVVALTAEQVAALEAEQQAMANAPLPMGDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTA2</accession>
    <name>A0A088RTA2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_230330</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Trp) + L-tryptophan + ATP = L-tryptophyl-tRNA(Trp) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699191.1">
        <property type="nucleotide sequence ID" value="XM_010700889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTA2"/>
    <dbReference type="GeneID" id="22575237"/>
    <dbReference type="KEGG" id="lpan:LPMP_230330"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230008600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_230330"/>
    <dbReference type="eggNOG" id="KOG2145">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261385at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000007">
        <property type="entry name" value="Tryptophan--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055:SF8">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055">
        <property type="entry name" value="TRYPTOPHANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN98484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="490" mass="54474" checksum="88B7962E440D7DC1" modified="2014-11-26" version="1">MRRVTCWPWALRAGVCTFTALRSTSERSDCATDPRELAQHPPGGGDADREDVITPWTVVAKGPQGINYDRVLTTFKAERVDDSARQHIRDAIAKCHERTASVTSVNAQNTPTPVSTAVSPGGVPAQVCVSPAAQQQQPPPPPPLHHFFSRGIAFSHRDLHKALDDIEASIKPEEPSVFLYTGRGPSAGTMHAGHVLPFMLAKYLQDVFNLPLVIQITDDEKFLFRGVPFEGAVAEEVILNNIKDIIAFGFHPRHTFIFRNTHYMGELYPTVLPLQRSMTGNSVKHTLGLTDSDNVGKFAFPATQAAPCFSTAFRRVLPNGDRPMRCLIPCAIDQDPFFVLTRAAAPRLKQPPPALLHTQFLPALKGLEHKMSSSAEENGVITLHDTDKQVRKKLRRAFSGGCATLEQMQETGANLKVDVAYQYLRFFCRDDALFADVTQRYGRGTMNSGDVKDLAADCIIRDVLHDWREQREKVSDDDVVNFCRIRDILH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTE4</accession>
    <name>A0A088RTE4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Exocyst complex Sec10-like component, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_230790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699236.1">
        <property type="nucleotide sequence ID" value="XM_010700934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTE4"/>
    <dbReference type="GeneID" id="22575283"/>
    <dbReference type="KEGG" id="lpan:LPMP_230790"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_110008600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_230790"/>
    <dbReference type="eggNOG" id="ENOG502RS7Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272443at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009976">
        <property type="entry name" value="Sec10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048627">
        <property type="entry name" value="Sec10_HB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100">
        <property type="entry name" value="SEC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07393">
        <property type="entry name" value="Sec10_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exocyst complex component Sec10-like alpha-helical bundle" evidence="3">
        <location>
            <begin position="693"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="239"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="39"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="257"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN98529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1105" mass="122248" checksum="0155B7EB03B0BA8A" modified="2014-11-26" version="1">MPVGMRTRGGVVSNKRGMADEDRRSGGGGEVTPDFASLASQLTSTLEEALEEVRHLLEEEETLLHREEVRCKRVEIREKRRLATVRLGLEGTSARLQLYENRVSNAQAATAGIEQHLTQSNARVQRGKSVSQLLRYFKMMTGISSGELRALLESISATRKTQRAAVTTRWAAGRVSALRPRFYTTVINLGASASTAKRSGLGSTASSATKRPVSSSPPLVGADADSEVGVDNTLVKQSISATAQTPETDAQLALTARRPRVFRSGARRGSRAASRDVSPRAQARSLSPQRSPRTATGDDGPDDNDDAARMQSDSGGEIVAEDGQDVQEETEEDDEAAAVMEDGSGGADGGAIVDLMQVRMQRAEAAAVAAGLDRLFALRFCTEAQVEWCQRLMLLANELGELASNVKNIRIYVNWLRKELVSDLFHIVTCFSDFYNAHPQTAVYQAYGRALLKTLGRISSLYNTLTPSNDELLSLFFSRSMNDLGLVLFSEWSPKPLPGLPPLPQPSDIRAMDHYRQHTDKELQRTFRFLLDCIRRNIVVVETIFGTTNTARQQLLSRVTDGVVRPFLSQQIKLAETQAASMMQAEGGLTPRTKRRCAARVADVIAYHHTMETRLYSFYQEYMKEIKSIFSANQVEFLGRFVDVIFVQRSAYSHQRTELELLNRYFTLIEEKYTRSLHAIPGEFFDLREAHMKKMKEVVTCLKEVAGRVKAYAIPKEVGWYVCDLIKATLAYVGSYLDSELRKVLDSLRSDRDNWRVKPKSEEELLQPPKLESQQCAIRMLLFAQSSLMSLSETANSICVPLLQQHPRLVQDIEEAWGSALEALDERSERVLNMCVQAILLRSLSILQHYQLKSDYLPKGDSKGSDVAAVAPPCTRACTLFCYYITRQFDMASEFIRLSNGQVHQRQTASQMASSRSLGAAVHQPKELLSQAARAAATEAVGGSRSSTSILETVVSPASGGLAASTSSVSAVRARARTMNLQQLLYGDGGPSSFVRTLGVCLYRGIAAHLKSFAANDRGALVYKQDVTAYKEAMAPLTSTPGLGGAVVEVLFQMLKETSSLLIMPLDHIREVKESGYLKLMSAEEKLRYLRIRQDVRSAMKIISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RU63</accession>
    <name>A0A088RU63_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Calcium uniporter protein, mitochondrial, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_270780</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCU (TC 1.A.77) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700167.1">
        <property type="nucleotide sequence ID" value="XM_010701865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RU63"/>
    <dbReference type="GeneID" id="22576254"/>
    <dbReference type="KEGG" id="lpan:LPMP_270780"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270014700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_270780"/>
    <dbReference type="eggNOG" id="KOG2966">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="278338at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990246">
        <property type="term" value="C:uniplex complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015292">
        <property type="term" value="F:uniporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036444">
        <property type="term" value="P:calcium import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006769">
        <property type="entry name" value="MCU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039055">
        <property type="entry name" value="MCU_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462:SF54">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04678">
        <property type="entry name" value="MCU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium uniporter protein C-terminal" evidence="11">
        <location>
            <begin position="118"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN99460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="319" mass="35484" checksum="C04EA020F8390FC7" modified="2014-11-26" version="1">MRSLSGTVLWRHCGLLPSVQSAPTLSHVCRRLSTLGCTVVTSRAYHTRPSKSAALSANDFASLTPLLLLRQALQQHTELDGTDVGAQLTPGEQHIIISRTKFCHFCATAHVEDPEAALADLEAAGVVVVLDGGSLIHLRPALYLETLEIIRNAATASNAGNRTPATNLVPSVNGSSFLLEEAERRVAELTKREKAMRYQLEPAIARAARWRRSVWGGALLYAGAQLAVISRLTYFDLDWDIMEPVSYIITITNSLVFFLYYLRFHSDHSYGAFDQRFLPRKVRQYAPKDFDWAAYADVCQQVVEARAILDCLSKWAEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUP3</accession>
    <name>A0A088RUP3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_272310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700317.1">
        <property type="nucleotide sequence ID" value="XM_010702015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUP3"/>
    <dbReference type="GeneID" id="22576409"/>
    <dbReference type="KEGG" id="lpan:LPMP_272310"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270031400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_272310"/>
    <dbReference type="eggNOG" id="KOG0231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="437960at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.110.10:FF:000025">
        <property type="entry name" value="MORN repeat, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215:SF14">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="102" mass="11275" checksum="F6C5BB5063FDD14D" modified="2014-11-26" version="1">MHGFGILDDSSSARYEGEWRNGLMEGVGALSLPSGGRYTGEFARSEFHGSGRYMWADGSYYEGEWCRNQMHGLGVYVDCTGKRWHGSFTNGNAAQLVAKVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVE8</accession>
    <name>A0A088RVE8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_282630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700602.1">
        <property type="nucleotide sequence ID" value="XM_010702300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVE8"/>
    <dbReference type="GeneID" id="22576708"/>
    <dbReference type="KEGG" id="lpan:LPMP_282630"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280032800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_282630"/>
    <dbReference type="eggNOG" id="ENOG502SIDP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266273at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839074" description="Transmembrane protein" evidence="3">
        <location>
            <begin position="31"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN99895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="31352" checksum="48DDC0FD012E72C1" modified="2014-11-26" version="1">MTHHSHSARTASVAVALTMIVMAALCCTSAECISATPHTRFESERLLVRILESSEAVTPIRSAPPGTAEVTGSLLRVMANALPAHASPNPERRPDETSQVRFTLAFAAGRVHEAANQARAVSPGVVAMGAVATTPAGKSPTLQASLSVQLSHRPLANGEEVHSVEQLSKASPLSPSHQRKQLVPSSYKAAGQLSAQQGSLKGTATEAVLVPRTVSINSSEEVLSSEGDYGAVLSSGVIASFTVALIFAGLLLILVLVEVCGMVIASVKHRRMRATREAKGADGPAELKRGDFRDTAGCVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVR2</accession>
    <name>A0A088RVR2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_262460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700066.1">
        <property type="nucleotide sequence ID" value="XM_010701764.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22576149"/>
    <dbReference type="KEGG" id="lpan:LPMP_262460"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260029400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_262460"/>
    <dbReference type="eggNOG" id="ENOG502REHZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272951at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19327">
        <property type="entry name" value="GOLGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19327:SF0">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1132"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1287"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1453"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="161"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="244"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="356"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="435"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="583"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="653"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="758"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="979"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1331"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1136"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1302"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1498"/>
            <end position="1507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1507" mass="166107" checksum="0FA91D3FDD33B562" modified="2014-11-26" version="1">MATQTVSSEAEGNALIKRIRQLEGEGATLSNTLTKVCEENGRLSGQISALEERVQTLVREPLKGTSVLHSLFEPEKTGWFGGSKSAAREKLEQLSDALQSEFIAYKSSHASSNDEVQALMEGLHNAHLNAQELSNVVRDQQELISGGPLAVAVHIVPFDESNSSAAMVRELQEQLRKVREQAALTEDQLRNSQAEVRAMNVENMKLRNGAIAGSALATAPAAADPMAAVSSAPLLSGKAATEELERMSHEYDVLQSALTEARNSIAEKEKDAELQRQKVAQLQNRLTAKDSVHMEEVGKLRQQLADSFSASVACGRCEELLQELEKARCDVDASHMVVQDLRNEILEMTAKQQNKYSALEKRLADNLDQLREKDQQLRHSTSADDYDHLKLEQELLTREIDLYKQRIAFLETSRNPANDVADATALDETKVLETLSATKERISKLEFERDQLAMQLQQAQSYAVSRDTEARQLQQRAEEDKQRVAFLVKKCASLAADVRSTTAQLDTFKEQFEKQSLELKQERRNTESMDKLQREFDDLTKAKGLLEDRLAATQEVEERLVKAKETIAYMELAQSSTICMSQFAEVKSEKEKLQSKVEPLERKLEEAKQEIERLKAVTEAQQAVSSTQNKNVRAWQDQVTALSESEAKLRDKVTTLTTENSRLTQVNASLEQQMNDMQDGIKEMAVHMERDRSSAKAAAEANSEKKIQTLCDELAQARATIAEVQARDGQYVAEGLYQSVVAEREKALEEIKRVTFELEKRKSEISIYRQTIADLEQENDERLKEIEALQDRYQSDRTGLSDRLAKEQKRTAELNSNVASLTEQVSAMEAAAAKHMATITELQEKNAKQQRVFEDKCRREEALSDEIKRLSAQIGTLQGSGTNTALQPESRSRSNDVTAAAAAGVGVAAVVCAAGLAAPPAACHSPAVTEMEAEVKATEPAVSSSPLTPSALTASQPLSERAVDGAAAHTASAPEPIAIEAFCKRIDDLLRDNQRLASELKRTELQHRTESADDQRMITILQTQIKNRMSTNNRTAYEAEIAKSAALKKSVETLMEENTKLRMQAGVAQAPVNMPASASSVAMAGTQQMDVLQLQSQLQAQKATFDSAMEEAAKVAETYEARIHELEEQLHEAEEAAAAAATGADAGGRTASDDGDGPLGKAAKKKTKKVKKRKTLAEQVCAVGDDADVLAAFPHADAVDADSQNSVDAGQLQASLMSAHHEVHQFKLENIQLKEEIAQLKATIVDLLAQLQRAEEDVRSAHEDLDMTQTAMNVERRDLQKQIDLLQTQNTQQRSSMEEKQLSASARSNSIGTNGGGSPSKANRSFHSFSIADVEMQLRRCQDEVGRLMAENRNLQYRLERQAGCTKPPSSATGAAVEATEKSGAEDIHKLRRQLKQRDAEIKTLSDQLMPTKEKLVEYMAMADRLGLQYPFPPELEGATVLRLKALHLPMTPRSASVPAPVQQRRRITPSGGGVGEVSPLPRTPRERRTGGDGGAARSEDKVFSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVV9</accession>
    <name>A0A088RVV9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Acyl carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ACP</name>
        <name evidence="15" type="ORF">LPMP_270280</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700116.1">
        <property type="nucleotide sequence ID" value="XM_010701814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVV9"/>
    <dbReference type="GeneID" id="22576204"/>
    <dbReference type="KEGG" id="lpan:LPMP_270280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270008300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_270280"/>
    <dbReference type="eggNOG" id="KOG1748">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="448946at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000035">
        <property type="term" value="F:acyl binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000029">
        <property type="entry name" value="Acyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002148">
        <property type="entry name" value="PRK00982.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="ACYL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863:SF28">
        <property type="entry name" value="ACYL CARRIER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12 13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 13" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Carrier" evidence="14">
        <location>
            <begin position="72"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AIN99409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="150" mass="16803" checksum="E2E866FFE6DF481B" modified="2014-11-26" version="1">MQRSLIRRLGNRSAFPLVVTVVRTSQVQPAVHVRSGFSARVVPSFMCPLRTYSGGHHEEQSSRSGQYLLDKNDVLTRVLEVVKNFEKVDASKVTPESHFVNDLGLNSLDVVEVVFAIEQEFILDIPDHDAEKIQSIPDAVEYIAQNPMAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RW08</accession>
    <name>A0A088RW08_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_301100</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701143.1">
        <property type="nucleotide sequence ID" value="XM_010702841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RW08"/>
    <dbReference type="GeneID" id="22577164"/>
    <dbReference type="KEGG" id="lpan:LPMP_301100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300016200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_301100"/>
    <dbReference type="eggNOG" id="KOG0755">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="442325at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051508">
        <property type="entry name" value="Mito_Carrier_Antiporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45928">
        <property type="entry name" value="RE38146P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45928:SF1">
        <property type="entry name" value="RE38146P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="102"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="215"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIO00343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="338" mass="37240" checksum="C6A91112A5A998F7" modified="2014-11-26" version="1">MSTVDMYVDGAVASMCATVISNPFDVMRTRMQLQGELCRRGEYKVLYNNLALGMVRVAREEGLRALQKGLASSVMWQVMQNGIRIGLYPAVRAEVSYACGSDAIYVSVLAGALCGLMGSYFSSPFQLVKTRLQSQRSTVVTTRCDALSKATTGEQYDYTGVRDAFRKIFKAGGLRALWKGSHIAAQRTLVGSAAQLAAYDVAKPTICQRMGWSPSDIRVHICAAIFSASCVMCFMNPLDVVMTRSFNHRVGEPVVYSSNLAVATWKIYRVEGVRGLYKGSMALFSRSAPHSIATFVSLEYLRKLRERYTSRSYTSGSTVDKSIGFHRLPDAKSDKHTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWD5</accession>
    <name>A0A088RWD5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_301010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701134.1">
        <property type="nucleotide sequence ID" value="XM_010702832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWD5"/>
    <dbReference type="GeneID" id="22577155"/>
    <dbReference type="KEGG" id="lpan:LPMP_301010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300015300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_301010"/>
    <dbReference type="eggNOG" id="ENOG502SE6R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266407at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="451" mass="47909" checksum="AD7DDF17C59A5859" modified="2014-11-26" version="1">MAAPLATSAADIPTASLACNVPPGATRADSRKRFPEALAESPQGPVPRVEAVDERKQLFRTRLCPTPLRVPASESAEWRCEALGASLTAPGVTFTDSVLGATFLNSLPSPCPLPRPPTPAFLPVAGALPPPSLSIAKTVPFSLEEHLTWLYAPASPTESRSSATVPPDMVAASCGLARAERVRASRSERERKHESSRSTVSATVTQHSDLPIAPADVQEKAAPALMQDQGSASTATTLIPPNPLAPQHGEISYESSFSVVTSWDALMVAPPLLRTTPRMPSLLAHDVAGVGTTAARFGRLATSVHVCMSDDATRIPFNGSQGESLIGTSPAMETNEASQGGEARAGAEQQKPVFPSSHCAPSPAAVPPRVKCDGHEWSRKDLLRQVEEDGVRTFVKHFTNGLVFVDPPWFICPVLLDNCEHPYYMTWLDELEVGSVEEAVAEAKAKLLADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWJ7</accession>
    <name>A0A088RWJ7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_300660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701101.1">
        <property type="nucleotide sequence ID" value="XM_010702799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWJ7"/>
    <dbReference type="GeneID" id="22577120"/>
    <dbReference type="KEGG" id="lpan:LPMP_300660"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300012000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_300660"/>
    <dbReference type="eggNOG" id="ENOG502RZE3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275766at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO00301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="198" mass="22813" checksum="DCE228E6F692AEE4" modified="2014-11-26" version="1">MFRICSVWCSNALHNSTPFVDGALQLMKLHLAHRNAVADKNKAACHAIEQEFFREVEVFRPCFTMAASLEVAQQYSKKLYAALKYFRMDDDPLIRQLDLLLGRKGMRDGRHRDQRGFFKGAHTSYASAFGKVAESAHNNLEEHVETTLPTELPHAPKVDLTAPRRPGALWINQRYRGHWVLQEPDIAITRSERREDPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWP5</accession>
    <name>A0A088RWP5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine/threonine-protein kinase RIO2</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Serine/threonine-protein kinase rio2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LPMP_301420</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 19">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701171.1">
        <property type="nucleotide sequence ID" value="XM_010702869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWP5"/>
    <dbReference type="GeneID" id="22577195"/>
    <dbReference type="KEGG" id="lpan:LPMP_301420"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300019200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_301420"/>
    <dbReference type="eggNOG" id="KOG2268">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10258631at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05144">
        <property type="entry name" value="RIO2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000601">
        <property type="entry name" value="Atypical/RIO/RIO2 protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000053">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000052">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030484">
        <property type="entry name" value="Rio2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015285">
        <property type="entry name" value="RIO2_wHTH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852">
        <property type="entry name" value="SER/THR-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09202">
        <property type="entry name" value="Rio2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="16">
        <location>
            <begin position="65"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="324"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="462"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="383"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="462"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AIO00371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="486" mass="55749" checksum="0D3F36262796FFDE" modified="2014-11-26" version="1">MVKLDVTLLHFMEDEDFRVLTALEMAMRNHDVAPTALVERIAQLPHGGCRKRLNNLLKHKMIHHENTMYDGYAMKYGAYDYLALRTLSKRGTCTGVGHRIGCGKESDIILVRDETGHDCVLKLQRLGRCSFRSVTRNRDYKGNGRTRHGESWFYLSRLASQKEYSFMKLLYDEGFPVPKPIDQNRHALLMELVPGTLLNNITELGDASKVYRRALELMVKLAESGLIHGDFNEFNLMITDEQRVIMIDFPQMISINHPNASELFDRDVQNLANFFQRRFKVDTTWFPMLTKDVVRKGELDKQVYASGYFTRKQQEDLERLMQEGSQLGEKCDSEAASRDRDSDASKDDGDGSASQSFDVNSVDVNEGGVGKLTSIPGGASGGEENEEREEGSDDDVNESRWLDEAMNAARVRRQGEFYPRNVHRNANFLSDGNINEDHVKHQIRRTIRCRENSDFNRHLHRNVQKGRQKQKIQRQLKSSNGEGFFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RX50</accession>
    <name>A0A088RX50_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">X-pro, dipeptidyl-peptidase,serine peptidase, Clan SC, family S15, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_282060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700546.1">
        <property type="nucleotide sequence ID" value="XM_010702244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RX50"/>
    <dbReference type="GeneID" id="22576651"/>
    <dbReference type="KEGG" id="lpan:LPMP_282060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280027300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_282060"/>
    <dbReference type="eggNOG" id="ENOG502QSSF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416441at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3020.10">
        <property type="entry name" value="alpha-amino acid ester hydrolase ( Helical cap domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050585">
        <property type="entry name" value="Xaa-Pro_dipeptidyl-ppase/CocE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00976">
        <property type="entry name" value="CocE_NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056:SF10">
        <property type="entry name" value="COCE_NOND FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xaa-Pro dipeptidyl-peptidase C-terminal" evidence="2">
        <location>
            <begin position="293"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="686" mass="76648" checksum="6610AF2B77251BB1" modified="2014-11-26" version="1">MRRVCLDPPHPTRFVEHIYIELKDKICLAARLFMPKDASSEKRYPAILEYIPYRKRNGTRTRDEPMHGFFAGQGYVSVRVDMRGAGESDGLLLDEYLKQEQDDALEVIDWISKQPWSTGDVGMMGKSWGGFNSLQVAARRPPALRAIVVLGFTHNRFTDDIHWKGGCLLNDNFWWGCLMQGFLSCPPDSDIVGDRWKEMWLERLDKMPLNAADWAEHHRYDAYWQQGSIQEDYSSIQVPVLLVDGWADSYTNALFHFLEELKVPCKAICGPWAHVYPQDGTPLPQMNFLRAATDWWDYWMKGITDNNVPSWPALQAYIEDSLPPCTSKPVAPGKWVAMDKWVNAEAPTVAYGLGAQRFLTEISKDSANMATGTVMVRTPLNHGLMSGEWMGAGVLGETAGDQRIDNGLTVTYTSAPLTASMDILGQPTFSVRLTCDQPKGLLFAQLCDIAPDGAATHITYGMKNLVHCGPEGDRAIALVQPGQAVQVTVKMDFCGYCVPAGHSVSLSLANNYWPMVWCSPANTTLLLDAATAVFLVPVLHPSAAIVPGPDPIPEVAASTPMTVISPGYVDRFVSYDIVRDTWTCVTSGVGGVFGEGIFRFDDIDTTLEHNLRRELTLSNRDPLSAHYTVTQKVKVNRPRCVTDVNITSTQHCDAEYLYIRSTIKATYNDEEVFEKNLFRRVRREAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXB4</accession>
    <name>A0A088RXB4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CYC2-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">CYC7</name>
        <name evidence="1" type="ORF">LPMP_303590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701381.1">
        <property type="nucleotide sequence ID" value="XM_010703079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXB4"/>
    <dbReference type="GeneID" id="22577412"/>
    <dbReference type="KEGG" id="lpan:LPMP_303590"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300040900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_303590"/>
    <dbReference type="eggNOG" id="KOG1674">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="337735at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF95">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO00581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="236" mass="26396" checksum="A155323A7FCB70B9" modified="2014-11-26" version="1">MSLRVRPYKTSAQTRLAEIVAAYVQHLMDLQASGCAEAILDGSVIPPPNAQYSSHDFFCAAHAPPISVKKYTARLVTYMHCSPEVFVFAVAYLRRLVLNGFPVHIRSIHRLLLTAVLVALKYRDDIYYRTSFYAEVGGVTPKDLCIMEMRFLFDLIRFEGEVSLADYHTVIRDITRVAEGHMIVKSISTESETCSQCGTSASTSTTSMPGDLDCLHETSDTCAHAWTRECEVFWGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXJ3</accession>
    <name>A0A088RXJ3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phosphatidylethanolaminen-methyltransferase-lik e protein</fullName>
            <ecNumber evidence="11">2.1.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_313010</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.17" evidence="11"/>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701683.1">
        <property type="nucleotide sequence ID" value="XM_010703381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXJ3"/>
    <dbReference type="GeneID" id="22577727"/>
    <dbReference type="KEGG" id="lpan:LPMP_313010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310038500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_313010"/>
    <dbReference type="eggNOG" id="ENOG502QRGH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4583at2759"/>
    <dbReference type="UniPathway" id="UPA00753"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004608">
        <property type="term" value="F:phosphatidylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000023">
        <property type="entry name" value="Phosphatidylethanolaminen-methyltransferase-lik e protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32138">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32138:SF0">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="555"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIO00883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="582" mass="66557" checksum="E243313EA1BD3147" modified="2014-11-26" version="1">MLAESVSEDAKRVFTPCEDGTSYGLLYDGTRFRVPDTMSVVDALLTPKSWRSPATLIWVAVCFAVGLTGIFHFTHGLPVWFFCAQFAFWRLAYNIGIGAILHYHSRYGSFLKFYRRIVKDYPVTRCFLEASVVFEGNTEYKVTRFPDEFNAWMLFRQVENVILANDLVSYCVLSVVCWEKMSLSSPVDIFCLVLGCASIAFALWCKSDAHRVIGDFAWYWGDFFFLLDKNLTFDGIFQMFPHPMYTVGYAFMYGVPFMTKSYTLFYMSVVGHLCQLAFLVFVENPHIDRTYNVLSSPTLEEQERNAVLYGNGGEAYLEHNELVVLMNFNIFRASDLLLALTIIYLLATLLLPLPAWIYVAHVIAWRLFHNGFLGYLLKRESHEKWFSLNYPSPQAAFNNWKRIYNASVTMTNLSYCLCAVKYFTWVMPLFGSGEARCFVMMVGMLLVGINGYVSWSIYKAIGDYGYFYGDFFIDKVPAKLNYSGIYRYLNNPDSSLGMSAYYGIALLSGSPVVLVVSVVSHAAAKMFEAIVEEPHMRKHYGDQVREAGGMQTELARRMKASKADYEKKMRAIKAKLDGRKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXX5</accession>
    <name>A0A088RXX5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_311900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701581.1">
        <property type="nucleotide sequence ID" value="XM_010703279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXX5"/>
    <dbReference type="GeneID" id="22577616"/>
    <dbReference type="KEGG" id="lpan:LPMP_311900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310025900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_311900"/>
    <dbReference type="eggNOG" id="KOG1471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1434354at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF1">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="134"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="355" mass="40308" checksum="F98F92FC8C104499" modified="2014-11-26" version="1">MSTVASAPRHRRYVDMTPEREQKITQLVQLMKQTYDPLPQQLQILLRYSPTPEDAPTPRNTTRSYCYYALISCDWDVQKAFEGMKRNVEYRLQCHLDERSELPSAISIRGWDQVEVVRALGKELRAGNQRVDQIVAGIECYFSFGLHYWDRYGQPVFYLMLGSVDEKNLLKKLKEAANVGQSADAVMWEVLQHVLGSGEWLAYYQQMQYDAAKLKVDASEGLIRATTIVVDLKGLTYKMIWKPAIDLLLSCLRELLDHYPQCIHQILVVNASSAVTLIYSLIRKALPDTVQAKIRMARPSESLALLTEYIEAQYVPYFYGGACHCEDGCVRSYNPKSPAKGTVTVDQDGASSATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RY11</accession>
    <name>A0A088RY11_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">fumarate hydratase</fullName>
            <ecNumber evidence="4">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_291970</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(S)-malate = fumarate + H2O</text>
            <dbReference type="Rhea" id="RHEA:12460"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="4.2.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:12461"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:12462"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I fumarase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="4"/>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700802.1">
        <property type="nucleotide sequence ID" value="XM_010702500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RY11"/>
    <dbReference type="GeneID" id="22576960"/>
    <dbReference type="KEGG" id="lpan:LPMP_291970"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000009500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_291970"/>
    <dbReference type="eggNOG" id="ENOG502QT04">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="411469at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.130.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.130.10">
        <property type="entry name" value="Fe-S hydro-lyase, tartrate dehydratase beta-type, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051208">
        <property type="entry name" value="Class-I_Fumarase/Tartrate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004646">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdA-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004647">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdB-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036660">
        <property type="entry name" value="Fe-S_hydroAse_TtdB_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011167">
        <property type="entry name" value="Fe_dep_fumarate_hydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00723">
        <property type="entry name" value="ttdB_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30389:SF16">
        <property type="entry name" value="FUMARATE HYDRATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30389">
        <property type="entry name" value="FUMARATE HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05681">
        <property type="entry name" value="Fumerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05683">
        <property type="entry name" value="Fumerase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001394">
        <property type="entry name" value="Fe_dep_fumar_hy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117457">
        <property type="entry name" value="FumA C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic" evidence="11">
        <location>
            <begin position="79"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-S hydro-lyase tartrate dehydratase beta-type catalytic" evidence="12">
        <location>
            <begin position="360"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIO00145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="568" mass="62464" checksum="0584BC97B9D04C6C" modified="2014-11-26" version="1">MSLCDQCEIGCHRAGIKDIEDAAAVNKDFHFSAIFQPTDPHHHETQFTKIEGSEKYVEEVVVFGREVLKVNPEALTIVAHRAYSDVHHFFRKDHLEGWRRAIDDPESSDNDRYVAMTLLKNACIAAGRVLPSCQDTGTAIVLGKRGELCWTGGEDEKYLSKGVWNAYKYHNLRYSQTAALDMFKECNTGDNLPAQLDLLAVPGSGYEFLFIAKGGGSANKAYLYQETKALLNPKSLRAFIEEKLKTLGTAACPPYHIALVIGGTSAEMTMKTVKLASCRYYDSLPTTGDKHGRAFRDLEWEAVVMEVAQKSGIGAQFGGKYFAHQARVIRLPRHGASCPVGLAVSCSADRQILAKINKNGIYIEQLEENPAQYLPDITTANLSITSVNVDLKRPIDEVRRQLSQYPVGTRVMLNGTLIVARDTAHAKIKEILDSGEPLPDYMKTSPIYYAGPAKTPEGYASGSFGPTTAGRMDSYVDLFQSHGGSHIMLAKGNRSKQVTDACKKHGGFYLGSIGGPAAILAKDSIKEVKCIAFPELGMEAVWKIEVVDFPAFIIVDDKGNDMFSKMLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RY21</accession>
    <name>A0A088RY21_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_321780</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701863.1">
        <property type="nucleotide sequence ID" value="XM_010703561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RY21"/>
    <dbReference type="GeneID" id="22577919"/>
    <dbReference type="KEGG" id="lpan:LPMP_321780"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320023400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_321780"/>
    <dbReference type="eggNOG" id="KOG0698">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000016">
        <property type="entry name" value="Protein phosphatase 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF803">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="12">
        <location>
            <begin position="135"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="452"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="510"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="473"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="517"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIO01063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="566" mass="62117" checksum="32280D1CA7CA7FA8" modified="2014-11-26" version="1">MMPLKRAPPRRPPAKQPMSPAKQMHYLSQQQIQMARMLEQQTRERRTYIVRSVLLFVTLTLMMGYGYYVYGVIVALTILIGGWLMGWLEVLQVVLAWVVRNAGQPNFDELLRRADIMSQPMKEKNSFSGENEFLEYGSSSMQGWRRTMEDAHTLLLLEKGGFFGVYDGHSGAATAKYCGEYMFQFVHQTKAFMKGEISKALYDGFIAIDKYLHTLPNFERGGCAAVVLYLDGDDVYCANAGDSRCVMCRNGSVDALSTDHKPFLPSEQMRIERAGCYVLNRRVNGMLALSRAIGDFMFKNNTQVSWEMQAVTSAPEVRVTKLNRDKDEFAVLACDGIWDIMSSKQVVDFVRPRIQERVPLGKICEELMDACLSPQPFRLGCDNMSVVIIKFKRGPQGGVQTAQTSATSSPHASLLYLPAVSSCMTDDNISALGKDDTSSPSAVAQIPDEVASTAGNAERAHSASGGEGAVSGDIKERGGTAERKNSLPKSPKSPKVFSANVAPAFSRCSVTNTLPTSDRHESRDDGLSSGDCAANSNASPLMMSTHPKVLSTTASPIDLSLKGRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RY83</accession>
    <name>A0A088RY83_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_322240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701908.1">
        <property type="nucleotide sequence ID" value="XM_010703606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RY83"/>
    <dbReference type="GeneID" id="22577965"/>
    <dbReference type="KEGG" id="lpan:LPMP_322240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320028100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_322240"/>
    <dbReference type="eggNOG" id="ENOG502RXTI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271109at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="458"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="500" mass="56726" checksum="9DDDC6969067727D" modified="2014-11-26" version="1">MQTGSDVFMNIILATLKSSNELVDGETFEIVSGSPALLKVFIDSGRVDISDPQVQSIVQAKLDEVLDGDPYKGDFVSGDLLDYVRFLCNIRTSRITFQQMVLLRYSGFDYVEILIECPYLLENLKKPSFCIYLIFDVLHYISVAISWLGVLVTLTFTAMVVWTVVFWFRNPNTRNNSYWVIITYVGSYVVSLVVTMRAEEGKIKHYDNQIWNYPDNIFRIVPIIPVYEIMLSYVLLRYEISTDAKRFFIIRYDLRNGTYVQHIANSCFYALPQMVLQTFLFTGVQHTPHAYNRIVFWLLLACALTLIVMSIFAYYQIAVFTHSCNNCGFAVLSSRSTSSKSYTGFLVRRVHPSDIATKVLVFFTMYFFIAQAVTLIVLLLNLRSCNNGTIVFLSIYTAILGISIIVLVLVYLNLPLSRVMGTMSIPVALMEIAFLVYINAGTTGPGCIISGLGTSKWIVPSIATFALMCLSIVTWLSMLLFEVFRGTRITQRAVDHYILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYA0</accession>
    <name>A0A088RYA0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_300300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701065.1">
        <property type="nucleotide sequence ID" value="XM_010702763.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22577084"/>
    <dbReference type="KEGG" id="lpan:LPMP_300300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300008300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_300300"/>
    <dbReference type="eggNOG" id="ENOG502SIEW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272882at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839146" evidence="2">
        <location>
            <begin position="27"/>
            <end position="1577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1392"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1518"/>
            <end position="1539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1577" mass="166193" checksum="2D122FC88CAD1061" modified="2014-11-26" version="1">MPCRRVCHVCACVALLLVAGWGGSGGAVNSTTQPVLPNAERVAVALADESISAATAFTNLMQLSEAVLAPVWSAGGFSYVLKSTGGTSAPVCAHTRASGGGITAPFTFSMFDTQFSPVYLVSLSAVESTGEAASLTAEVAGRLDLRRGCYTTPTSLGTCAGVLQSSPPQCMLGELDALHTNWTADSLAAATSAMRADESLTLSSRGLSAAEVLTVFMSDYLPQRAWLRTAVPRVVDALAHAEQAARAYRTIPLTLWDAAEAAEMQRAVAGQWGGYLWSTYVPQLQRKWALLYRLAVATLTPLQMAPSLDDTATGFITGVPGPAPKTSCLMVDAWVQLQHSVASSSSSSGLRTFARLVTYMEDALDRLGEVLSNGGGAGALSEEQADTLVSQLLQRTYCVTTTYLFSLTALFDAPFLHASSSVWVEPATHMHAWAMRTMQEASVADALANATVFQEATAARVARVSASLPRNEKALLACLAMFLDATRPLTSAATTSPSDCVQALLKARADASGVPSSAALGVLWDVSEMRTVKPTSAAVPGITRYESSVPLATAFPAAKASLQHEFIHWTMFQQASTSFTGQRSLYTPSIVASAPMNPCAAGHAADAALHTGLNRAASSEDRHRVLVGAQVAETCPAGTYAKPDAASCEVCPSLCSASPTPPTPVYCPGDGLMHGCPVLPAGALSTGSPNAGLDNAKAACRYACIDVYQAPLHKGCVSMPGLFYNTTAILSDGHSGGWYDACVGPASLLPRGFPAQSHDARVFVFVGSGATDEPMSCRFVLMHRVVSSAVSAETLWAVGLLPPPLSVSAPSATATSSAGLLPHRGGVAWEAAMQLNATLLWEMHRSLLRSQQQASGTGTGAVTTSIGHVLVALREGGEGVASQSRWSWSLVSSYQHPAGVEAATITSATDTAPPPSVSFTLRLLLNASILAIPQSTDATTTWRGCTEVFSMTPAPSSLTVLSSPWTWSVKSVGVDYLAKATYRVVLSRSTSTVAFFADAAAVGSPVTVDWPLWKHSQMTSPPSAKTTMYLSVAGWVARYVEREQWMVMSPSFSFSSSPQPSTLPLHYDYVPGMMTRLSSTAFPVSPLHEALSRAEASWHSQAQTTAQQQSRDVAALTDVHLLSLYVASFPAVTASVSAVLNGLSVRQSRGLDGVCRSSYGSTPTVSGTSVTPACAMCTSGSYTVLNATPDRSKCACLPQRTSVYMTPSAGQQVRACLRRPDGPAAPSSYMRPPGLLFIDSDVAVADGVFLGWYGSGTGATGTGLPAATSLEGSVICTYGLTVPRLTTTAPSTSLNLSVTLQYTTGLGAEECHVMAAARGDSPAYTTQPSYSAISSYGLRLRAPRLPVRAIALVINSRLFTDQTVLTVSVRDYALLPRHAVDSLMHMRGITEYHVAFLIYILRCATVSAVLRCGSTLRVARNFTWAGSSSLDSLVLRVNLTGMITEACQVSFTVLSATAAASEASVPHTSWPYTYLATEANASLFFEASPTVHYTLHPSVETFAATKLRYDPLAEDSSLVISSILLALSLSLVSIILVSVGPPSLHPLSWRAYERARARRHCQHRQLHNASLLERGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYE4</accession>
    <name>A0A088RYE4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein kinase, putative</fullName>
            <ecNumber evidence="6">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_320840</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="6"/>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO00971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701771.1">
        <property type="nucleotide sequence ID" value="XM_010703469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYE4"/>
    <dbReference type="GeneID" id="22577825"/>
    <dbReference type="KEGG" id="lpan:LPMP_320840"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320013400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_320840"/>
    <dbReference type="eggNOG" id="KOG0198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051700">
        <property type="entry name" value="STE20_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47096">
        <property type="entry name" value="MISSHAPEN LIKE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47096:SF1">
        <property type="entry name" value="MISSHAPEN LIKE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="829"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="140"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="543"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="617"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="141"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="543"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="554"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="617"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="858"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO00971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1111" mass="123068" checksum="B7683C411D76EC85" modified="2014-11-26" version="1">MDNALGKLPATRWDRLVAVLEENEPERTIDALHILEQAKKLNLSDFELFYLLLKRYQERQPRILIDVVSLYAMMSTWMEWIVQAQCCLDAQRNKMDASSSFHTAKVELGSVQTSSDLADSGPTLPFPSSNNCSSRLISSNPVDSSTNGDNGCGSQLDSPVRASHKGASSTLRGLRRKSDCRSLSTRPHLCFELGPGWKWDGLLDFLRNGRVLSCLVEEALGLCGKLEALQDHLSCPETLSLSTDELLHPSPTDMNRVIKDVAIDGATGGASANESFSPQSYLSTLDSSRLSCSRRGNVKLSKTLKMIEEQRKNLAASEQWVRKLNDMCERFLGWERSAHNNSVFFDLCNLNNFVRPLHSDDAHLLYRLHWLAVALYRVVNDPSIIPAPPRMSFIVCRDDLSGLLDTSEEDNEIDLLVAAKRSCLPLKTRLSVTMKDANIMQLHHPDMKASPRLLRCALVKGDVFVYFEEYHAFVPVWSVFQYFIQHLDELTWRFEVSRKEREQEQQVLGTTFSLMHGRLGATGDFTVNNGGATFDLTIRSSTMRHDCQRRPSEAPSNTQSMRSSTTPNPFDSLVDCKAPVTVLPRSFSHRSVTQAGTGIEVDIAVAKALLSRMSISSPHSAEPSLSSHSSPNTTRPDYIPLPPLNLATGEGITNKSYAVSSTADGDSTAAAPSASASGIGIALNAIKPPVSDSSTSAYMVSPLAPKLWSEARDESAEDQGPLSRETVTLMVERKDAVECDCNADVISNDVALMTSSCAVSCTPTPQVVVAREAHFHYGIDALNKDEELISDATMTLMSSEKYMSIRNFTASVFQESEQSGIALFSHRFRVSSGPIGKGAFGAVYKALNLDTGRIVAVKQSRYSYDDNTADLNWREFRMWSMLPPHPSVITFYGASREVDTHQLLLVMEYASGGSIVQLYRQFWPIPESLFYNHALGIARGLKHLHDYNVIHGDVKPENVLTRSDGSVAISDFGCSRFSLVGTDSDSSSFRSSLRESGSLLLFGTAAYMAPEVILNEPHLKSDAWAYACTLLQLWLGEAPWSTGERCFSALDTIPLMFYIASEEVVPFTTEQLERSPGWLQRIAQRAFERSVERRCSMAEIISILGEHRRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYX5</accession>
    <name>A0A088RYX5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">tRNA/rRNA methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_322790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01164.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701964.1">
        <property type="nucleotide sequence ID" value="XM_010703662.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22578020"/>
    <dbReference type="KEGG" id="lpan:LPMP_322790"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320034100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_322790"/>
    <dbReference type="eggNOG" id="KOG0839">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="241340at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016423">
        <property type="term" value="F:tRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18091">
        <property type="entry name" value="SpoU-like_TRM3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.10:FF:000044">
        <property type="entry name" value="Variant surface glycoprotein (VSG), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056921">
        <property type="entry name" value="TARBP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045330">
        <property type="entry name" value="TRM3/TARBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044748">
        <property type="entry name" value="Trm3/TARBP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12029:SF11">
        <property type="entry name" value="METHYLTRANSFERASE TARBP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12029">
        <property type="entry name" value="RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25050">
        <property type="entry name" value="TARBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01164.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2039" mass="222722" checksum="43D28A37ED7E3586" modified="2026-01-28" version="2">MPMIISLVNQLAARHNSGGDTSHTEDAAVRVSRLFLVACDLMGAFCPADLHQHLEDMMTRQWAALLHGESFQASPPASSNTPEPATSSHLSPSSDYVPTLIAASGALLGYARTHIEEFRACGVGREWIDGVCDRWQSNVLQLLSAHPPFSTEARTAVCYTVAQLSLLPSHCCEQVLQASFEALEAGREDGLSANIAVELLGQIASLMVVCKPFQLHGLTLEDPTTTAAAATTAKGGATGKNGAGSMVGAQTEKPSRLSTQRPAVDRAGAGASAFSRATIVSEPPTANCSTIPSCYPFPSIERVEELKVSLIQCCLISLGATVTEAGTVTSTAVPATRTYQGRQRHRTVPMALVCQRVLIPLLLLDGSQGLEQYEHIVHDLLRTLASCSGTSPTTASVSPAPPGHTRGAAAEDAALLSHGDHCDEVVLLIAALFDFLFRQPSLNPCTDFRFSEFLWTVLSSALHQSLTVTKTDAGHRANMQLRIEYLLKRIVHMTKQQQQELSTGAACAALPPIIEFHPLFHWYTATSSSGDCAAGEKRSSAAAASGDSLSATTWESFFLVLESLNEYGWHIIEPVMARLDALVAQLDNRLKSAEAPHDTTAASTVGVNSAALHPRWIEMLLLKFILHPNLGVRKVGLRRIWALPSRVLRSLSSSFLFQYAFQSASDPRLCCGIDRVPITASFLDTKSFEGTEVKAVPDVEPLAQEVERFYASLFSHRWSSSDDGPAMEGRIDALRRMLDTAIKKPPRFTVCVLARALLAIANAFLDNGINAEAVLLDEGVLERLHHFLRDSVQENIPFWLDVRVTVILFAALTTFAAATASPRRCRLHPSFWRLYCMCGPLGESGGHSIASMDACGQYGLVGASVEERFLQHWLVQLSVQQQQEPMRRVKFGGAAPSLVEALLDVEGLLCRAEALLQTPPELDSHEAVNVVPAKETFFLVGTLTRTGSARHAELVRAIGDRIATTIASLQTRAYCTAAQVLTSVACLVEFQHSVGAAVCAQLWPVSTTLQSMSSALHGHIMAALQASLRSIREAAEAPRQEGPRYSLFQDEMCDEVDIAWSLMNTANLDVVAAGVTALNAIACASATRVSATAAAAAAAAEVLHVPQHVQQLMCLLRECTTAYEATYAPGASTAVDEKARQKRLAVLLIVGRNVTRLLQSELCGCLSVKHEESTTRQAPLDGDLDLVAQRCLLFPSALPTCREAPPFSAAASSRCPIAMLLPQDVLEVYVDQLMALPSQRVPSGAVPSALSNLPWATLLSQQGRYVCNALYVLLLCLTAAKQEHTSAEASNPTRTFPGLVGRVQNYALGQLGECWTMNLASVYDLLFWVASSNMPEVVDYVAIANGMWEHMREVGARQYTRLAALAFTVLHYVMPHHPGYVKEVLLRVLEVEGKDAQTSDRDVYFASMTASLQVLHDPDNNWSVLREVLLYTAVLFNTNRDEEENESTVAVTEPLLWTWPEALRLCYPPTTCMSAVGRAMAVATLLWCCHQNVSGRAVPLTMELLRMNTCHPVVTHEPCMPNSRTHRTRMRLWQLLCALLPCLADEQSVPPTQVVEVFRVLVRHCLTVNNMGSIRRLMELYGIRLMEQRPSLYTVLSEALGSYSLRPQVCGSYLLIACHSLLRQEGAGCIKESASATAGDEALASDIFTSLFPRILQQSTSNQHLLRIISHIGLFNICQRRLARGRPISPAVAAIYDYVRHAPEHAKFREKHEHMLFFDTEEASSPRSLFCVQRKEANTVLTEVLPAAAFERLRFVETEMCCMIGALYPMELLRVHDWCASLRVQELVSVLKGFRGIPHTSTPSEYYVDYTREATQLLTRDPMLEVTAAAATARSTGIGASDEAGGVDAATANVQKKVSSWWTSEVYNELHPRALRTQKQSIIVVGSLLVNPVNIAGLCRCGEIFAVQSIVVPDKRVFEHPHFVAAARSAELWIPWEEVMPKDLPCYLEGLRRRGYMVVGIEQTAASVSMEQFSFPKRCAVVLGAEGQGVPAPLIPLLDVCVEIPQYGLIRSLNVHVAGAVIMYEYTRQHLMAKPHLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZ50</accession>
    <name>A0A088RZ50_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Qa-SNARE protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_331410</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702233.1">
        <property type="nucleotide sequence ID" value="XM_010703931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZ50"/>
    <dbReference type="GeneID" id="22578294"/>
    <dbReference type="KEGG" id="lpan:LPMP_331410"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330019900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_331410"/>
    <dbReference type="eggNOG" id="KOG0809">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251371at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15845">
        <property type="entry name" value="SNARE_syntaxin16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF83">
        <property type="entry name" value="SYNTAXIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="203"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIO01433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="275" mass="32232" checksum="1AFE9412EC2A0468" modified="2014-11-26" version="1">MELIIRDRFIEFAERRTAVHTKYGRSESTVPQTPTERLFIVPLWSRLPADFEENALALSHQIDELHSMHFLFLEPKLRRKEEEDQLHTLIDKQTAEIQALLKMLEHTIVVGAQLKTTYSEEEVRIVKSIQMQLTTRFKELALQFQSVQKIFGALLRRREQKSNKYTKIGSEAAYETVQQEERVAQFLQMGITEQDIQAFLIEDMQRDQTNKEIKDILDSIQEIHRMFEDLHTMVVDQGSMLDRIDYNVDKALVSVSKAQIELEKARENHGNCILM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZF6</accession>
    <name>A0A088RZF6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_330380</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702131.1">
        <property type="nucleotide sequence ID" value="XM_010703829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZF6"/>
    <dbReference type="GeneID" id="22578191"/>
    <dbReference type="KEGG" id="lpan:LPMP_330380"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330008300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_330380"/>
    <dbReference type="eggNOG" id="KOG0305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF8">
        <property type="entry name" value="FI02843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="500"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO01331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="728" mass="77791" checksum="E238A754313AD0BD" modified="2014-11-26" version="1">MQQWTPDSNSESPESNGRPSALSREARLFRTEGRSTRRSTRSEHRRASREVFPTEPFWTLCHNDKGDDEDEEGRHSAPQRLSRHIPQRVGIDMTVSSFNLMASTACGVQTSVSSPLSVSCCGGRDYSRNPYCAAAPTSRYVTPGATHLSTATATNANGYAAAAAPTPSSSAFTSFSESMVSDDSSYMTSLYNDVLADHLIGHRGGVVTAVNGGSTDDPGATVYTRAILTSGANLSVCESSTAMSDERGVTGLSTAKCGSSLHASADGPVNSARRGLGGEVLRFADTTHAEATPRSLVTASPTETSSLHLATFSAKGTARVVASTATATTVGAGLSSALPRVRCRTIYTSGSGSRGICGTRVFNTTPERVLDAPQFPPKATQLLDWGVNNCIAIGMGQSLYSWSGDSGEAMKVVELDDAVRICCLQWLQKCSCVAISVQDGTTAIFDSRTSSFLRIVRLPPELEVTGLSVKGPVLAVASDGPYGTTCAFDLRAKDALVAIYEGHVGGVTTLHYCAAEPFYLATGGSDGSVRVWDARRASTPRYAFDSVHQGSVNVARWDPQKRSRLFTGGEDGIMCLIDTHAPKRTIEMDTMPDEEVVGFGCSHEHLTQYVTRAVNTQYPISGLVCHGTNGEVLTAHKNKGQLQLRKASTFHLLTTFTALHCDASLSCLTMAPDQERVCAAQADETLKFWRVFEKSTARGGERNGVGCVDQGRKPLHQDLSNFLEEPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZU2</accession>
    <name>A0A088RZU2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosyl hydrolase-like protein</fullName>
            <ecNumber evidence="6">3.2.1.96</ecNumber>
            <ecNumber evidence="6">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_332380</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.96" evidence="6"/>
    <dbReference type="EC" id="3.4.-.-" evidence="6"/>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702329.1">
        <property type="nucleotide sequence ID" value="XM_010704027.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22578391"/>
    <dbReference type="KEGG" id="lpan:LPMP_332380"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330031500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_332380"/>
    <dbReference type="eggNOG" id="KOG0324">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2331">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21221at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033925">
        <property type="term" value="F:mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06547">
        <property type="entry name" value="GH85_ENGase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09212">
        <property type="entry name" value="PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.2190:FF:000010">
        <property type="entry name" value="Glycosyl hydrolase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032979">
        <property type="entry name" value="ENGase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036339">
        <property type="entry name" value="PUB-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018997">
        <property type="entry name" value="PUB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005201">
        <property type="entry name" value="TIM_ENGase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13246:SF1">
        <property type="entry name" value="CYTOSOLIC ENDO-BETA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13246">
        <property type="entry name" value="ENDO BETA N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03644">
        <property type="entry name" value="Glyco_hydro_85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09409">
        <property type="entry name" value="PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143503">
        <property type="entry name" value="PUG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="5">
        <location>
            <begin position="14"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="339"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="619"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="341"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO01529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1425" mass="153717" checksum="0AC5F04B6A5247D7" modified="2014-11-26" version="1">MFSSSLSSSSATRNTVSLYRYDLTQGMARSLGPMLIGQVLEGIWHTSIVVYGQEYYFDGGVGIVGDPNPGHTRFGQPYRIEVLGQTAKSEEEFFAWTQQQRRAGFGPNDYRIFDNNCNTFSDAACMYLLGRHISQDVLDMLPTLLSTPLGQMLRPVLEQATSSGAGIGGTGMVAPVSSALAHPPPPPTTASDRDTCVGLLSTRQTVTETDEEDLMMAQAMLESNETIADGHLSPAEAFEKTISGLTLLRTVMRNICEHPSYAKYRGLSIESTAYQTKLRPLEAYGVTELLRIAGFRRRSHSSGAGGVQWFLSDSDGSEAVLRRVAEVLEATISNIQGAADEAAKRRVREESDSSAHLPRPPLSPTLVSSIAPAAGHAAASFEMSLPPVSKDGGHVHKSSVFQFCSPPFPEDWTPLPVGQESGAPLFSIHCLATSSVDGLYCFGKCHLSENQQHVQAYYCSSDGREVETRGGYEVLCVRRGQAKALTWVPAPLASAAQTQHNSRFIFSGYGRFGVVRAEYGGGVHPGVMEPSGRCVVPYGGRAVIVTNDAEVLCETARLPAVVLQELQGLERGTYLAELLRVASGQPINSFDELLNTWRPPTFYMRPRSLRPHTVLEPKSVEWGGAGDTAKRSATDATGPEFSSAGTESTAPVALPPATRLLVCHDMAGGYTRADRRAFLCEGAPVGATPSAGAMGKDPRATSYSCLQTVEGAYTVRYWSRADHFVYFSHRRISVPPREWIDSGHSHGVPVLATLITEGDSGAADLKLLLTDAKRMAAIIARLVEVCDAYGFDGYFINIENCLSASLAKRLVVFCTLLRKQLNRPSSATRGALSVTPATNRLVIWYDAVTIDGSLNYQNTLNSRNKAFFNVSDGIFINYFWEPMSLPLINTVAGNRGAEVYVGVDVFGRRMYGGGGYNTHVAVAKATGARLSVGLFAPGWTMEHESKGKRDGFHIAESKMWSRVQENFPYHVRLISPTAVTAGAPQPFTTDNAQAAHDGPALCAWTSFQSGVGYDFYVNGRRVTGGGSTASVVGISGWCELSAAHSLPPFLFEAPPSAPPSGALPPAAREAASSHPGPFASVPIRLPVTPLKGNMYGCTASAEWRYDKAWFGDCHLACLVPSMGSVEVLRWYVRDALPATSLTELHIEMVFDETDASEGGPKMRRGLRLGLFSSTRGTFQVSIWERAAVAAAVAVEGVSGLVVRASRSREGRHGGEGNPIRVTWGWERVHYQLCNTSTELLHLTSISIANGDPCQTLKCGVGGIAISHWRVTTPIVATGADVQAVSLERPSLLCAHGPHSWTPYYTFRTRKASEQVLTLGGADDVFARLRAKHGLHATIIVFASVASATAELGVNDTTSTEEYVQAAAVVPSDARRREEFHTMYVGQYSIHPDAGTTYEGSLLIPVSLPSGVAVAHVQYYTVQNGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S044</accession>
    <name>A0A088S044_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_320330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO00920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701720.1">
        <property type="nucleotide sequence ID" value="XM_010703418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S044"/>
    <dbReference type="GeneID" id="22577774"/>
    <dbReference type="KEGG" id="lpan:LPMP_320330"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320008100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_320330"/>
    <dbReference type="eggNOG" id="ENOG502RZ28">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1687175at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22710">
        <property type="entry name" value="X-RAY RADIATION RESISTANCE ASSOCIATED PROTEIN 1 XRRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22710:SF2">
        <property type="entry name" value="X-RAY RADIATION RESISTANCE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="701"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="714"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO00920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="829" mass="90435" checksum="3991361D45E9E3BF" modified="2014-11-26" version="1">MSAPPSSLISFPISLAPSLSACLYFMTARRLLAVVAAAFFFSLCPICEISDENDALLPPSAGLRGGMSLTWQRRPFFPPQRAAAMDPAMQEESPMHLDLLQGALPSASAEQKAEAADGGPTCESASQRATIPLKRAVTSTTWAAVCPSLAMLGSVGDMEFTVGGSLLPPHLLVHPQGFRILKNASVLERNMRSYFRLPQPPNAATREERRRLRRILERIEGEEVQRKARVTGNQDGVVLDGFLVLSACEAEEPDEVTQVTLQSSQLSSSVAGDLQYFTHLTSLNLSDNRLRLGHVLPFPGLKDVHLMCNGIASLEEVPQLSSSSLATITALNLAYNHIPANHLSYLKAFDALQQLDLSHNGLRALPRDLSGLAHLTHFALESNELSSSDVFYALSTMPALVEVNLARNRLSSIPPLSAGSCDGNSALRCAPFPFLQVMNLTGNRFQRVEALRPLAALHRTLRRLAVGENLLLNRQPYQKAEVQRVLDEAVVDAYYAALLPPQTDSSDPSVPPEMMNTWHCQTWTRYIPQPQGEADISEMDVVEAALIDPSSLRDTTASAPAAVASNILEADSGGLVSENTHHQDGVSPPLPTVAEYLRRYRIHVQTPRATPPALPKQPTRYFYSSTFRQSEQRTHGVMPLVTLPPYSEFMDVYRVLGRRRPAAQGRGGGVARSAAVRRAEAQRVFPPQPMCLPMLPHVPIPPRTEATVSSQQVGDEEGDEEPESAQRGRGFFLTGLDDAAMRSLRDVPRDRKATAAPPPVETQLELTNKLASVAAGTADELLPRTRLPRSVVSPAATNVHAAISELRVMLRKPLPSLPYDSSRTKLTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0D8</accession>
    <name>A0A088S0D8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_321290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701815.1">
        <property type="nucleotide sequence ID" value="XM_010703513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0D8"/>
    <dbReference type="GeneID" id="22577870"/>
    <dbReference type="KEGG" id="lpan:LPMP_321290"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320018200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_321290"/>
    <dbReference type="eggNOG" id="ENOG502RT5H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277958at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="481"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="637"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="715"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="497"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="637"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="721"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="746"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="763"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="798" mass="88841" checksum="8C5FA3699FB4B19D" modified="2014-11-26" version="1">MTEAAGERGRLTFKGRRRLQQEVQTEASFVPSCSSLEYAYDPLASEQYENLIELRQMIQSCLTLVAGDVYDVVSFKDILYQLESEMPSALPVTDMLLLSSRLFRRTAELGRLLSCFFGVIFADDHNDEHFRFAEVRLLQHEIRELKQQLSASEGERKQLKEMLDSVGQVAYDHGMAVELLETHNKVLKKQSIALEDQMAVLFHQLNTGLEGDCKASYRQMMGEMKLQESLNPARITFRQTMDSLSEQLRNSRRLITEVREVLLSCSQGKRTGEAYATVEPSVRFKLKMLESSFQQLMGRFTAVKDTVVETAQELMSALQERKKILYLSFQHIRLYDLQNAKLRNARAILSQLQHNTSEVMRRIHVTFPSGNITSVDRFGKICTQRWHGGYTLAKLRGYKLTEQQQQQGEGELAEPVRSSSAGRLLSAGAARLLPGLSESQIMAAESEMAALEVGVHNTQSAALPQPFGTGNKRVSHSGVILTPGRTSAPPSYAGSKLASTRESNNAVDTPAADVAPTSMQSDDREVLPFDCISTFLNLMHNVDVDMEELQRALVLDNEMRAFLKLLTLSASTTPRADALEIAGGLTGDAALLERREYNMEMALQPTGSRPGGASGATYSVSVGTGLENLTAQENNSLSSSFSKLGSRSSSLEGRGGSRGENASSEAVLSRQSVQLQRQQKQITKMQEDFTSKIAFLRQVYEARIGDLEVRETTLSRRLGQAGTSPLQRSTGDGSNGQSPLLGGQFEEERTVPMRQGDKEKLTKLRKIWRQSKRKMQPNRGLRESTANELLHTQEEDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0F4</accession>
    <name>A0A088S0F4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_342620</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702688.1">
        <property type="nucleotide sequence ID" value="XM_010704386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0F4"/>
    <dbReference type="GeneID" id="22578767"/>
    <dbReference type="KEGG" id="lpan:LPMP_342620"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340032300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_342620"/>
    <dbReference type="eggNOG" id="KOG2615">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="419616at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF15">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="442"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="503"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="286"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="529"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="632"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="296"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="531"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO01888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="693" mass="74357" checksum="23399E9A63C647AE" modified="2014-11-26" version="1">MPISPVDKGTTTEAEGSAPPLERCANNCRPLKDTPLPWGQLSIICVVLLTESICWSVLIPFVPSFIAYIKGWDVDSSGYASGFPVGLFMLGQVVSGKLWGMLSNMIGRKVTIVLGVSGCAICMFFFGLSGSLLAMCFWRFTHGLLGGCSIVAKTMISDLTDTTNRAKGLALVSLTWGVGTLIGSAVGGALYNPASSSALALLHISSTSFVGSHPAFLPSAVVAGYNFFAVVICVMCLQESYRDARPLRDVLPPFIVKLMAPVLRFVQPRLPCDCNATDVTAMCADDHNETGSSAPQKPPPTAARPTPASPSTPHTPFGFKQAFLNPLLRRVCIISMLIATSDMMFTEIFPLWVASDVRNGGLHLSPFQISILVLMNAAPSVLANVVFAPVIQYAGGPVRLCIAAQLMYGFFTAMVPTASSLGKRTRFWYTIVFGMLRKAMEAWNYALTMVMVSLTAPQGKVAIMFGIQQSLVCLVRCVVPLVFAPVFAWSIAKPHPFPFNHYLVFLLSVIPLVIGAYIATHVYVPSCNSGDGEEEEEELEGSSDRVGVGNGGQNSRLNSACGSLCSIYSLFGSVSCDVPARESLLRNSAANSLVTLSSPAMTQHTIFEFPTGSHLLMAVEDAVSAPRMQLDEAGDSRDNSSQEGDEVDNNTEYASLADEMAVIPVVPRDGVLEQEDIRIAQRSTLLENEELPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0Q7</accession>
    <name>A0A088S0Q7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-dependent RNA helicase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_342130</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702639.1">
        <property type="nucleotide sequence ID" value="XM_010704337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0Q7"/>
    <dbReference type="GeneID" id="22578718"/>
    <dbReference type="KEGG" id="lpan:LPMP_342130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340027200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_342130"/>
    <dbReference type="eggNOG" id="KOG0920">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="243823at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001737">
        <property type="entry name" value="ATP-dependent RNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001780">
        <property type="entry name" value="Putative ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF255">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="150"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="362"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="58"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="629"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1110"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO01839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1140" mass="126501" checksum="C19C659BAF21B356" modified="2014-11-26" version="1">MSIHVHAAPYPPPPKSTVATAAAANFTDSSMRKRPQAMQKPYAPLNYYAASPLRVADQHVKDHHGRSHRGPKKDHLQQLPQPQPPPLSMPPRHNKTTPLAHVTGIDPVVAKRFQDEYAQQNDNENIGDDLRAQQATRMGTVGTLDEALCLSLIETHDVTFVITDTGTGKSTRIPIALHRAHPDALVVNAQPRRTAAINLAQRVAEVLEAELGESVGYSVRGEHIGDIGETKIMYVTTYSLLIYFLWHEFKEKLPLSYIIVDEFHERTPDVEVILLMLKLWLQKHPGAFKLILCSATAQVEEWQSFFDGLTVGTYARSPIMYPVQEYFIEDLERLTGIRTAPILPQDSSNMVTSEQMYQLILVCKQLLEYLAKNTATQDSVLVFMPGRTQVELMTTWIRENLEESLEPIAWYRDVELSLIQEALARPAVTRKKVYVATDIAEVSLTLPDVVFVIDSGTGKRPQVSEKEKTSYAFPPLRLLWETTSNAQQRRGRVGRVQQGFYFSLLSRAHYKALRESDNRIKNAVLTEVVLHSLLITQKPFAFFQLCNEKPERGALAYSLHLLQDGGHIIRKDDPMADAERVSLDRQRTTHVMDSPWNVLIEEALAVASGALATAPAEAVRGFSVTKETAAGPVRSGEGSDKDFGDEEDSVEAANLEADAAAFQQCYFMTLRGVIAARSPVSVAAATNVFFGLLYGTPTLSMLAAAIESSKSPFHIPYTINDRMERVAMVRRVSSVMQRYHGFLQSDLICSMEVILEYMSMQRDGLSEEAQEEWCQERSLSRTRVVDTLNLFSQMKEQVSSVLPFPDVTDIDVLNAQFNQNAELLVLMLVASHTELAIQVQLDGPVAQRKGFVGHGMFFPLKCLKDESVPTVCPWDRNKISVPLSLQTIQRKVLAVFASQVEPDLFALVLLVFSYKLHYSMQCSGATPSFLMAVSHSGVRRTFQCDALTAQQILQLRRIQCAQLRCMQLQVEERVKANESEKLSAALKSANSDFGLPDSAMEAPYLIPTVLQHGLKLLVGRLKGSPSYTAQRRDIVEFLPGTPYCKRANSAELSPPVLQSVLIHSNNGLSVWQPTATAAAVAASSSTVIEAVSATERNGVEVVAPAVSFPAVESESERGEEDESDHSSDSGAHVPTFSYDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1C3</accession>
    <name>A0A088S1C3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5'-deoxynucleotidase</fullName>
            <ecNumber evidence="8">3.1.3.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_343990</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.1.3.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HDDC2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.89" evidence="8"/>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702821.1">
        <property type="nucleotide sequence ID" value="XM_010704519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1C3"/>
    <dbReference type="GeneID" id="22578904"/>
    <dbReference type="KEGG" id="lpan:LPMP_343990"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340047200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_343990"/>
    <dbReference type="eggNOG" id="KOG3197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10254258at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002953">
        <property type="term" value="F:5'-deoxynucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009159">
        <property type="term" value="P:deoxyribonucleoside monophosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3210.10:FF:000011">
        <property type="entry name" value="HD domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039356">
        <property type="entry name" value="YfbR/HDDC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845:SF13">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13023">
        <property type="entry name" value="HD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="12">
        <location>
            <begin position="38"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIO02021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="206" mass="23636" checksum="B123B1A9EB78F235" modified="2014-11-26" version="1">MSFTKGSKAAQDVISFLHTIGRLKDTPRRGWVEHQICRPESISDHMYRMSLMCMMCPDTSLNRDRMIKMALCHDTGESIIGDISPAMKVPKEVKKQRETQAVQSLCKRVSSSPNTTFSEELRDLFEEYEAQETAESRFVKDMDLLEMIVQAHSYESMNPGKDLNSFFRSGAGIRHPWARAIFETLLETRPYLAYQKGEQAKKVSNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1F1</accession>
    <name>A0A088S1F1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminoacyl-tRNA synthetase, putative</fullName>
            <ecNumber evidence="3">6.1.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_030660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.1.1.15" evidence="3"/>
    <dbReference type="EMBL" id="CP009372">
        <property type="protein sequence ID" value="AIN95301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701009.1">
        <property type="nucleotide sequence ID" value="XM_010702707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1F1"/>
    <dbReference type="GeneID" id="22571932"/>
    <dbReference type="KEGG" id="lpan:LPMP_030660"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_030011200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_030660"/>
    <dbReference type="eggNOG" id="ENOG502S5MJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5592174at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04333">
        <property type="entry name" value="ProX_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="entry name" value="YbaK/aminoacyl-tRNA synthetase-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30411">
        <property type="entry name" value="CYTOPLASMIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30411:SF1">
        <property type="entry name" value="CYTOPLASMIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="YbaK/ProRS associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YbaK/aminoacyl-tRNA synthetase-associated" evidence="2">
        <location>
            <begin position="102"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="254" mass="27189" checksum="2D4F2D0F96596768" modified="2014-11-26" version="1">MERCKQHLVTKNAAFLIERIQVFNESSATVELAAVRLNCEPARIAKSLSFSQRKVICKAEAKAHEKAKMKLSKQQQQQDGSGAGGSESVGTLPADLPTTAPDDANVIVIVAAGDAKVSAKKYKEKFACQPKMLKREEVEPYTGFPPGAVCPFGLHDAVKVYLDVSLRRFSYVYPAAGTANTSIKVTLDELEQYASNAIEWADLCEGWQPEVGVAASRAEDTCDGSGTAPHEVQNAGIAAKKAQNEASKSAEATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S208</accession>
    <name>A0A088S208_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_333000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702390.1">
        <property type="nucleotide sequence ID" value="XM_010704088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S208"/>
    <dbReference type="GeneID" id="22578453"/>
    <dbReference type="KEGG" id="lpan:LPMP_333000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330037800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_333000"/>
    <dbReference type="eggNOG" id="ENOG502SFKS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="244134at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO01590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="115" mass="12542" checksum="664A18E2940950AE" modified="2014-11-26" version="1">MSQDTMYRHQLWHIEDPSLTVSQARLKLLFDFDPPSQYRLQPNGSLLHGIRPSCVLCGSVNPPGGAAAAPPAAPITTRRIGVFGRVGSVPVQYEEPFVTEWTDVGLPPTSTKEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S230</accession>
    <name>A0A088S230_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Memo-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_351190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MEMO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703056.1">
        <property type="nucleotide sequence ID" value="XM_010704754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S230"/>
    <dbReference type="GeneID" id="22579148"/>
    <dbReference type="KEGG" id="lpan:LPMP_351190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350017500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_351190"/>
    <dbReference type="eggNOG" id="KOG3086">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="417112at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.830.10:FF:000005">
        <property type="entry name" value="AmmeMemoRadiSam system protein B, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00055">
        <property type="entry name" value="MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04336">
        <property type="entry name" value="AmmeMemoSam_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060:SF0">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="328" mass="36621" checksum="AF50566B0C3AB94B" modified="2014-11-26" version="1">MHFVRSATHAAPHGCGWYEAIPERLKATIDDYLREVTHHYEDESRGGARMMGLIVPHAGMSYSGRTACEAFAVFREYLYAKGSKGSKVERIFILGPSHTKGFEGCELSAASAYETPFGPLKVDTATVDRVITALCKAGVGAATASRRTDEAEHSIEMETPYLSHILHYPPAATGTSTQPAAARVSIVPIIVGWTNRQDEKAICDVLKPYMDDARNFFIFSSDFCHWGDRFSYTYHYQRYQYPNIGDSIIAMDHAAMELLERRDLEGWYGYLRTTKNTICGRAPISIGMQHWMDEASKVQIKFVHYSQSNKCLSVEDSSVSYAAAIILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2H5</accession>
    <name>A0A088S2H5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_354710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703403.1">
        <property type="nucleotide sequence ID" value="XM_010705101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2H5"/>
    <dbReference type="GeneID" id="22579499"/>
    <dbReference type="KEGG" id="lpan:LPMP_354710"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350055400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_354710"/>
    <dbReference type="eggNOG" id="KOG0958">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="250656at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF107">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13771">
        <property type="entry name" value="zf-HC5HC2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="561"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="812" mass="88756" checksum="841365023DA84F81" modified="2014-11-26" version="1">MATAGAITKAAAPKKNTVDYIPSKLGYDTAIPVTILEDRSDFIEKCKPYDIIDGPNPLDDSEVTVATRPRTPTALVPPASEVILSERLIERSSRRRSHSGLKAEKPPATKQEREDEEEQDRAAFIFTRPSRDRWAEERLADHRPYQLVRSSDIETYVQYVLDDVDYDWCEREKVSPESLQRGVTYLEWAYTSSLLKAARPHVTSPKDSGTAASDSVVTRHGEAAHLSSTLSSSHASATVTSNGRCTYSRRQKGKDKTSAGDVPLFLCALCSMPVPVLMSQPWTSAEGCATGGPNSLHERQGEATHSTGAFSSPPIARGDIRIGGRYTGSVSALQPPLPALHSNRGLSDVGAGAPDPSQDVQYKGLRCCDCGVVAHLRCWFFSEPPKRPEAWICDGCTAYARHHRRSACVCCMCSRPGGVLLPYVSSAAKDNSDGVEPKSPHVSPPHALSSSAAALSDMVCHAVCALSIPELSVHFHDTVLRRNGLVDMQMRPYVYALRRVGKPRYAMNCVFCHHGSGRCVQCSHPHCFEAMHASCAAEAHTIDWHIESPFVPTIASFSSASAGPPAGNSTSNGITPPVSPGSSLMSTASWTSCSPYCRKHYGYAIGNSVSSAALGRKAEAEALALDLTGLLTGGDGLTSPVVRKRGRGRPPAAVVKQREAERDLISRLRAYWLERREQRRQSSAQLASEINARLRPIVEASLRPEIVKVSAEKVRLSHFLSLVPEWQWQLVAIVEGELPLPDEEYDDVQKFRKVTHTRHSGNTRSLYDKMCASAVQLDLLCQVAEAMKEQCRLRRTSVELELAALQILSGWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2X6</accession>
    <name>A0A088S2X6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Myosin heavy chain kinase a-like protein, putative</fullName>
            <ecNumber evidence="7">2.7.11.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_354670</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.7" evidence="7"/>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703399.1">
        <property type="nucleotide sequence ID" value="XM_010705097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2X6"/>
    <dbReference type="GeneID" id="22579495"/>
    <dbReference type="KEGG" id="lpan:LPMP_354670"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350055000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_354670"/>
    <dbReference type="eggNOG" id="ENOG502QVA3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="301415at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016905">
        <property type="term" value="F:myosin heavy chain kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031037">
        <property type="term" value="P:myosin II filament disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903013">
        <property type="term" value="P:response to differentiation-inducing factor 1"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04515">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.200.10">
        <property type="entry name" value="MHCK/EF2 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004166">
        <property type="entry name" value="a-kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051852">
        <property type="entry name" value="Alpha-type_PK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45992:SF2">
        <property type="entry name" value="EUKARYOTIC ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45992">
        <property type="entry name" value="EUKARYOTIC ELONGATION FACTOR 2 KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02816">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00811">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51158">
        <property type="entry name" value="ALPHA_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Alpha-type protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO02599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="287" mass="32647" checksum="6B051ECE3E9C243B" modified="2014-11-26" version="1">MGHGGMRVCYEVEDVDEEGAGTPMVAKMFRRNISDVVEKDYFNEGEAQCMCEEFANNFNRIHLTNVNKPNISFLQCYVVRIPRKSIPEAYQNKRTGFFSYKTQDTQEVMFVMEPMLSGRFTKYNSNYGEIYREDKKAALTSTEAKRRTQIFEAAEAFSHFTLVESGGSMLVCDLQGVNDFLTDPQIHTEDGKGLGMGNMGQEGIDKWIEKHDCNEICRALGLQPLSGIVTNSKEPKKAENPYLGLRAKLKRQNPVRLRDLVPLPKPLEEMTDAERIEYALKVSQLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2Y8</accession>
    <name>A0A088S2Y8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_356040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703533.1">
        <property type="nucleotide sequence ID" value="XM_010705231.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22579632"/>
    <dbReference type="KEGG" id="lpan:LPMP_356040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350068800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_356040"/>
    <dbReference type="eggNOG" id="ENOG502S807">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272660at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="996"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1131"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1858"/>
            <end position="1881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1144"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1858"/>
            <end position="1879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1986" mass="213401" checksum="6A4CBE75E931C9BB" modified="2014-11-26" version="1">MATQISVLESLANLFSSREVRAPSVEVALLPRLGRLADSDALENHVGESDYIVETLAAAPYSVLNDASSSSSILLLPELQSPVISLPIQSSSSAPQECAYDTRLGGGWPQQASATSELASLTKALSVLSAILQRSQRAHQRSRNFGHLLTLLTDGRFVATAAEQVQTLWLRCNGHAGLVGAQAGEDAALSLYCDVLLLVAYHARTAGSSDKVSSSLVVSEEVLASLYAVNRDMGAELVRAAAHRPAYLGRSVVSLTAFCILQAAGLPHRVLEDALLNLELGSAAQANMAHMAFMAALPTTWSHMTLMWQCRVLEVVRKATLYDTAADVASCTDSATAVCVIKRISAWVYGYAMHSFLSVMSEAAWYYCTADALLHISRAVSVYGPTWTAYSESYMNLVSFLHRALSRYELPYAQGESAALRVAAPGASKGTLAGSSRATLRANQRVGVHSTQRTESSVESLMRRAILGAAGAGNDAGFPDQQRGEDRITCTAFHTSDSASVEGDGVLGESDDSPESFLARCEADPDSPRNFVFYLSLLAYVTSALPSLLDSLGELRLFFYLSQSTRTTVIANNAAPAGGAEATEAPHSASGRGRSLFALCMDGLRVTLNSALAHTTEKKSVQDREKRLLCESATTLLCAFLCQFPHSLQQLEKEAGVCHLVSLANQVVTTILKAPRPSLRMKRLAYRLLQRYASAVDSLEGVMAHLLAPSHWAALRLDDEYVEADWTACLQLYPHLCRTIYELSPAEPGRLVSLLAGIPAGAFSCSSSGAATATTLVHAIFTLIEDHAEDATLFAGVTVPQLPQVIARIGEALDTLAKAYVKGNWMVGGESTWCSVCAAASLLYKAVLLYDVPALVATAVFPAPSGLQGRISGGSVMSEMRDGGGACRSRSVVQVLLQLLCEDLLAPIHHAVTELLVAALHATALRRTSDFVLQMFRSHLSPNEVVAITQRILQMQRVNVGSPSNAMRLELVQAMAMWCPALFLFVFGPEKRDVGEDADASEGAADGRCGSGDSGVDSGSVDQPKTQPAGLPLMQLLVETVRSDKAALYEKALALNILRCSGMTRLVPVQEIVSLVPRNDGDETKTNPSRKGGEWEEATLVVACVAYVNARVALELSKAKLTGSTLDSCAASGAGGEVNDSNKSTTSTRDSTTPPPTQQRRSTLVPLSPFGSTSARSKVLAPYTDIMDQLLRHGAAALQRVRSLYDVEWCEVDYDDQTNWLARQATRLTLGENTDVSASVILPRGSAVTASKRLACGSQLDSVHTTLHRTSQVSALSRCAVPTALAAASAARAKRELSNTATSFHTLSSESVEVVAAHRRLFPVGTAATRFFLGTGDDQRLNSLAAQLDTMADLATALGQLLWLSGVDTYTAGLFGKRTQQLLECAVESVLSCQPGPPMLAPFLTRQVQQQLRLAKAATSILESAVGNEAAELLEMSPTGQHSLRRLVSFAKANRRNTFVLLDTLPVVTAFPLSNFTTYATMEELMAMVQEALHAKLQLCTWTAETLVMLERLVNGCTRVFSRPRTGGCGDAVLVSRLLPTLMQVASRLSRFVQPTQPTNTDALRFVRVLECVACVIAHCGEQMAAVGFVEEDVLLGFLQALGQFSASSVYDAAAQRHLRLAWSVCWIALLSLWCTIMSVRGQYSAIASGWVPSLKAALLSSPRFAAALSAFAGVRGADRCRLLLWEVEEVDWCTRLVAVLAVQNVLLEKLTPCVQAGFVFLRQPHLQQQCVSSLPSAEVAISEGKRITIAQSYVLRSELTILLKQPSYAVPRDGATLASFVFPLELLGQTVELASAPSLSNDDVAAASTAISLVYSLDLLRQFTLWELQILRKVAATSAPTGGIGLERSSNMGLTSFASRESSVTRSSSKRPLAGDADTATDVDDSFTADGQIDIATDVQTVHLETVQLALMAYAFTVQDFIQNARNAPRILYTAEVVSGVRHSMERLVRTLRSFVKDLSEVRWPLLSRVVQGQTAQLQHFIECL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S363</accession>
    <name>A0A088S363_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_344130</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702835.1">
        <property type="nucleotide sequence ID" value="XM_010704533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S363"/>
    <dbReference type="GeneID" id="22578918"/>
    <dbReference type="KEGG" id="lpan:LPMP_344130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340048700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_344130"/>
    <dbReference type="eggNOG" id="KOG1819">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5872154at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051765">
        <property type="entry name" value="PH_domain-containing_F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46280:SF3">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY F MEMBER 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46280">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY F MEMBER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="318"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="162"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO02035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="377" mass="43288" checksum="325CCD9EDBCA7208" modified="2014-11-26" version="1">MSSSISSPLLLEAEVAPAPHGTIRFEDLGEPVQRLLRSLKGDVSDEDMALLEYVSVRDMAKIYSEMATDRHVKEIWRELRSALQARKEKMARREAELAEKQRALEADQRAEEERLRQQLEEEERERIASEEARHQRREDRRRLRAEKAAAAAAAEEEVAAQAAAAAEEAAEEAAAAAEEAERQRRAEKKRKRREARARELQEEKDALAAERASHEAKKKQKSLNQQKDWSEFVQSHPLEYAQSDLVDGAQQQLPTVIEQKELRHTLNAPPVVSEKLLSRTYTPACGACGSRFDRPPREWNCPMCNRRYGKTVKVWQPDNDTDNCMMCKEPIGRWSRHHCRNCGRLVCANCSEKRAIIEDLGYDIPARVCYDCYRLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S4T3</accession>
    <name>A0A088S4T3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP deaminase, putative</fullName>
            <ecNumber evidence="3">3.5.4.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_130870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.6" evidence="3"/>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697169.1">
        <property type="nucleotide sequence ID" value="XM_010698867.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22573197"/>
    <dbReference type="KEGG" id="lpan:LPMP_130870"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130013000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_130870"/>
    <dbReference type="eggNOG" id="KOG1096">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1723809at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003876">
        <property type="term" value="F:AMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.20">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006329">
        <property type="entry name" value="AMPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359:SF0">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19326">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="451"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="551"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="829"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="564"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1674" mass="185149" checksum="DE4A658B40F0F90E" modified="2014-11-26" version="1">MEQRWHDILLHHDIGDEAFHKGAPLVLEALQIIGDVQSISAATRLGLHLREAEHSRAMNQLDSTFTEKYVYRDHAAHAAAAAPLLERLSDFFQGCTPADAVAAEAMPLTSSLVAVAELDGLLVPSAVWTAVSRAAAMPSSPQPCASLTAEAATSPSTRNPVIPLVTELRSYPLFSYKVFLNHFNRLSSLISNGEVFSACEPRIKVLQSRYNLYRAYNGGREDEYHPTFGGGDIKRAPKCDLRRVETCVSAASVVKFIEELRRDQPSYPLYTEDVTENTVGEVHVKEATSAHNNSTASGTVSCISVEEAVRRFFGSNVAISERVLTEEGLCLRPSYAVDSADRWLSLQQLADSGDNHRAAYASRLLQHLLSTSGGADGEGELLARLLVPILKRVLTSGSSYDRLELELTVSGKDVAELPRLARWCAVSGLLESCPGVFFRFHVVQDAYRAGTEGKSQRRQYHQQLATQAESHDAPSVSSPPASPSLFFGSILHNIFSPIWEAFLAAAAAAGRVGSGGDAPPPSTTRRVAEMQSLLRRTTGFSVSLTNAAAVQEMPPTSDPSNQFPLPGSNNSSSSGSAHAAAATSLAPPDAFFVYHVWRNVQLVNAFLLASGEQPKKTTGDAATVRDATASTPAWNTRPAFTVTLHGGANSRTLFGESVLGLLLADAVVNPSTAFEWSPLTYLFMLTQRHVILTPSRNRCCSASVKRTLRLTAIPLAVQAGLHVSVATLDPLFYDTTNDALSEELMELTKQCGLANADVTEMCLRSLEASSGCLTWAERRHLLGYAWPHAQARYTQFSATQVSSLRLRHRACALAHELDLLFSAVREGGSSSSGDGGGDGDATTTGPQRSMCSWRNEARLRAILFLPSSANNDNNTSTSVYRRTASDSTRALELEHDPALLLHLPGYYAHEASMQYPRILIAGPDWSGPSAAAKHLMTAMATREAYQMFVIHSEDAQYMQSERSYGDKGKDSCGNSQAALRLVWRDGVLNLEERQPKQRDSYADSVPVSSPSALPTWAQFQKDTRMLRRLASADPSVAKYASKRLDMLEFKYKLHVALTNDDEENYTITTATAAAAAENAERDSVDSRARTATMSHRCVEQTARGDAHNCVKVDVHRHMASGMTAKSLLQFMQDKVRDHPDDVVGVDSKTGASITLVEFFDEVLGEQQQKPKPQLSAVTQGADRTAVRRATQRVPAESDEVSAADSAKAAEVAHLLAGMPIAALQVHAGKATFHRFDRFNHRFSPMGMASLRSLFLKTENFMHGRYFAELIRDSFKQNELEGGTFTENRLSIYGRYRGEWDRLSRWFVLHGMAHRTNSWMIQVPRLFHLYQLSGQLRSFQEMLTNIFEPLWEASLHPDKYPYLHFFLSHISGFDSVDNESDQEPDKMIDTPPEQWTSTENPPFAYYIFYMWVNITTLNRYRAARGLNTFQFRPHAGESGDPDHMADVFVLADGIGHGINLDRRPVLQYLYYLAQIPLAMTPMSNNALFRRYKDHPLPNFLYRGLNVAIGTDCPLIFHRTEQPLLEEYGAAETLWNLSAADICELAANSVRASGFPAARKKEWLGPLYYLCSVAGNDVTRSHVPQTRCAFRYEAYMEEVTYLQRRAAREMPCRAMRTPLEEEVNIMDAVGISRSELLERRWNGAEIVEKQRCWSLSPPLLDGRPTRIGKTHDASHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S807</accession>
    <name>A0A088S807_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Centrin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_202070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698408.1">
        <property type="nucleotide sequence ID" value="XM_010700106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S807"/>
    <dbReference type="SMR" id="A0A088S807"/>
    <dbReference type="GeneID" id="22574416"/>
    <dbReference type="KEGG" id="lpan:LPMP_202070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200026100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_202070"/>
    <dbReference type="eggNOG" id="KOG0028">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000077">
        <property type="entry name" value="Centrin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF48">
        <property type="entry name" value="CENTRIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="34"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="110"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="146"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN97701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="181" mass="20837" checksum="8DA525715C942F3F" modified="2014-11-26" version="1">MNTSNRLSGPLRTTAPTAPGPSAAARRRFQLTEEQRQEIREAFELFDSDKNGLIDVHEMKVSMRALGFDAKREEVLQLMQDCAARDQNNQPLMDLPGFTDIMTEKFAQRDPRQEMVKAFQLFDENNTGKISLRSLRRVARELGENMSDEELQAMIDEFDVDQDGEINLEEFLAIMLEEDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S896</accession>
    <name>A0A088S896_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RuvB-like helicase</fullName>
            <ecNumber evidence="8">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_203210</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="8"/>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698523.1">
        <property type="nucleotide sequence ID" value="XM_010700221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S896"/>
    <dbReference type="GeneID" id="22574532"/>
    <dbReference type="KEGG" id="lpan:LPMP_203210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200038100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_203210"/>
    <dbReference type="eggNOG" id="KOG1942">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000010">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000001">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="65"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN97816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="459" mass="50303" checksum="64EC287567DF3C0A" modified="2014-11-26" version="1">MSSIKIEEVISTTKKERVAAHSHVKGLGLNPDGTTKHIADGFVGQEKAREAAGIAVDLIRSKKMAGRALLFAGPPGTGKTALALGIAKELGPKVPFCPMVGSEVYSAEVKKTEVLMENFRRAIGLRIKENKEVYEGEVTELRAEETDNPLGGYGKSISHVIITLKSQKGSKLLKLDAAIYESLEKEKVSVGDVIYIEASSGAVKRVGRSDAYIGDHDLEADEYVPIPKGDVHKKKEVIQDVTLHDLDMANAKPSQGQDALSIVNSMMRHKKTEVTEKLRQEINKVVNKYIDQGVAELVPGVLFIDEVHMLDIECFTYLNKALESTLAPVVIFATNRGSCRIRGTEIRAPHGMPTDLLDRLLIIRTMNYDVSEITSIVEIRAHVEGAKISEAALTKLGTIGENTSLRFVAQLLTPALIIAETNGHEVIEEEDVDLVDELFKDGKASARLLQDHAEEYVYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S8A1</accession>
    <name>A0A088S8A1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Programmed cell death protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_203260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698528.1">
        <property type="nucleotide sequence ID" value="XM_010700226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S8A1"/>
    <dbReference type="GeneID" id="22574537"/>
    <dbReference type="KEGG" id="lpan:LPMP_203260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200039000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_203260"/>
    <dbReference type="eggNOG" id="KOG2061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="366284at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052815">
        <property type="entry name" value="PDCD2-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007320">
        <property type="entry name" value="PDCD2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46421">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46421:SF1">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04194">
        <property type="entry name" value="PDCD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Programmed cell death protein 2 C-terminal" evidence="2">
        <location>
            <begin position="294"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="402" mass="43751" checksum="E5783AFFBEBBFDAF" modified="2014-11-26" version="1">MSGVDLPPVWIGTPQREAAQEDVADPYTSKIGGQAVYFRVGASATEQQSSGALSKYFQCPQCKSTAQVSLLCQVYAPLEVYDRVLYILVCAACTRRPTATAPFQGGARMPALTPGSDKKSGLAAAAAANSHTSFCFALRSQNFSREYFAELQQQLSAEAQKVTKAEKEKAENDAPLFGVSDDWDRDDEPSKEARPSPAAPQDNTGNTDGAVEKTPEEQPTFPLASRGMTAPLKGVLYTSGLALDLYEEPPPKWKKEPSIKEQLAAAESMYNSSVTLDTSGFEEDDESPAEACVRAYMEQMERTPSQCVRWCPGGTPLRTSTMPIGVNGGFLPPPCPACGATRQFEMQLTAPVVYYLTKDIDEVKNLTVHFSNVLVYTCSSNCYNTDCNLPYLPEYVVVEDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S8B7</accession>
    <name>A0A088S8B7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">serine C-palmitoyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_203460</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="5"/>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698548.1">
        <property type="nucleotide sequence ID" value="XM_010700246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S8B7"/>
    <dbReference type="GeneID" id="22574557"/>
    <dbReference type="KEGG" id="lpan:LPMP_203460"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200040900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_203460"/>
    <dbReference type="eggNOG" id="KOG1358">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3168162at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF2">
        <property type="entry name" value="SERINE PALMITOYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="11">
        <location>
            <begin position="110"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN97841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="488" mass="53792" checksum="38714C43FDA28DAA" modified="2014-11-26" version="1">MSSLSKMLAQELMDHPLHIMLELFFAAALAYLLLQRCSCRERAKPPHSMNVLSLEEQERRIAAFQSIPFRGECSVTSNVPVPEYHGLTEVVGRKGCHITIVRPDSSEAEECLDLATYDFHSFSTMPEIVEVARTAVNAYGVGSCGPRSFYGTIKPHLLVEKDLATFLETDDTIVYSFAYTTVATLISCFSGRGDYLVYDDGVSSSVMEGCMLSRSDIRSYKHCNMKSLEEKLKEVVAKDGYHKPHRRFVVTEGVFSGTGEICPLPSILELCHEYKFRLVLEDSYGFGALGKSGRGTPEHFSIPTMDVDVYIGSLSTSMGAVGGFCAGASNMIDHQRLGATAYVFSASLPPYITASVSQSLAVLTRDATFVAKLQKHTRRMRNHLREARFNTEKIKLVDSIDDVSPVILLAVQRAYVKSEGLKKVESRLQRVINALQKKKVAVVRNVFTTDEPVNAVSGLRIVPKSLATEAEVTTALEAIEAAVKAEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S9R1</accession>
    <name>A0A088S9R1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_220830</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the MICU1 family. MICU1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98376.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699083.1">
        <property type="nucleotide sequence ID" value="XM_010700781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S9R1"/>
    <dbReference type="GeneID" id="22575129"/>
    <dbReference type="KEGG" id="lpan:LPMP_220830"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000029700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_220830"/>
    <dbReference type="eggNOG" id="KOG2643">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="186625at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990246">
        <property type="term" value="C:uniplex complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036444">
        <property type="term" value="P:calcium import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039800">
        <property type="entry name" value="MICU1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12294:SF1">
        <property type="entry name" value="CALCIUM UPTAKE PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12294">
        <property type="entry name" value="EF HAND DOMAIN FAMILY A1,A2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN98376.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="868" mass="92814" checksum="AB50DA9A9A958D31" modified="2026-01-28" version="2">MTLIRRMLAFSSGVAAGVSTAPYLCVPDRTPVAPRSCLQTCDTRCSASGCHGGSSSGNPAEKNGIDAASGPARVACVTESLLALYGGVCDLLNMATRALVEATANAAATGVHRATSATTAEHTHNSPVCSNDTAAQCADCHLRGATEEERHLVKPASNTEVPSSASTQSNINKRAEAFRAAPHKLKDRFLHYAMRDPATGELVLSLEGFVRCMLLLPDDGGADVLWRHAGSGATRKSDAAMQQNPSRAFPGTAGTTVDSLFAKAISSRGQSRRRYSWLLQLPPPVLQRFIQLFHWIDLDESNLIGYAEFVVLFTFLSTPQQTLERAFRVFDLGDNGRLNEWEFCHLLNTIMVDPAVQVRYAAAVSGAGNIGEDDAAASPSSACTSATPHATTTTTTATTPYSTPRPSFTPEAAKLAAVAAVASVASASRPCTAGHTGALRRNAQERHRHKDSLTYELSSELMRPFLFGPLPLHIGAPPGSTHYDRKAALTAGAVASSTSAVSALPVISDSAWWRQWGQTLRSLLSKVWTPYSSCAPASCGAEYSTLPLASVTASASTAAAAAPSHLSHLQMVAQEDSLLHAVSYPTFLYRVNYLRWELRAIEFSLCDPANTGAISLDDCRRLLCGDGRGTAAKVHPTLRQQRQSGKTAVTWPSYQKILDVVRESDKILVALQLTLDAMPPVPEEMLRGGAIPDEVLGAATQTIPRIVRLSALRQASTAAEEGVAVDAAPLPATAEDTTSQNEGSDGADRIPFIPADGVATSAEEGKHLGEKHAASCQAQAPLVRPTALTWNQFNRVLVSLSVVAQLSEAERSLFRELLDEDDSDSLSPAEFARVCALKETFFAQQLPRFDEPKRNAAQQFFYCMQQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SAJ6</accession>
    <name>A0A088SAJ6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Membrane-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_240060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699348.1">
        <property type="nucleotide sequence ID" value="XM_010701046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SAJ6"/>
    <dbReference type="GeneID" id="22575415"/>
    <dbReference type="KEGG" id="lpan:LPMP_240060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240005400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_240060"/>
    <dbReference type="eggNOG" id="ENOG502S4CR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="262479at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839357" description="Membrane-associated protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="400" mass="43745" checksum="EFEC09DB44D1BF9E" modified="2014-11-26" version="1">MTPSSLLAVLVLFLVTLGFVNGDVSFNFNGMIVLKNATLNTDFVVTTSFVDLITSTLQDAAHPRAPLMTVVQSVPPHLVILLNMWYTGTPTDVQTAISNINGTYMRWANGDALNASGALSYACMTNIGQQPTVIKYTNSCSFWNAPLPPSSAETCSRNLSLLFYTADLSELDPRARLKSALCTFLSTDCDLISYGDLAVAQINLRGSLTTVHVMPFTVLSQNREATLATLVTYAQYASVLVEYNITYILADGVQVFFKGFPPQLSTLGTFEKCAAQMWYLIFLIILVPVIFMVSHRMFLRGRVSGKRSIAKSERDIRAGVHLNSMPWANFGGGGGYQYYPQQVYSGGYGGGDGSQQVGGGDATQENAPPQSFEYPFQTAAQGWEGQQYGAQQYDRQQYVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SC34</accession>
    <name>A0A088SC34_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mitochondrial DNA ligase, putative</fullName>
            <ecNumber evidence="6">6.5.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_261330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.5.1.1" evidence="6"/>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699953.1">
        <property type="nucleotide sequence ID" value="XM_010701651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SC34"/>
    <dbReference type="GeneID" id="22576036"/>
    <dbReference type="KEGG" id="lpan:LPMP_261330"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260018200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_261330"/>
    <dbReference type="eggNOG" id="ENOG502QTYC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="411785at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08041">
        <property type="entry name" value="OBF_kDNA_ligase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000032">
        <property type="entry name" value="Mitochondrial DNA ligase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029319">
        <property type="entry name" value="DNA_ligase_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050326">
        <property type="entry name" value="NAD_dep_DNA_ligaseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47810">
        <property type="entry name" value="DNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47810:SF3">
        <property type="entry name" value="LIGASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14743">
        <property type="entry name" value="DNA_ligase_OB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00333">
        <property type="entry name" value="DNA_LIGASE_A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="5">
        <location>
            <begin position="266"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN99246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="477" mass="54171" checksum="E7D21870796F4C8C" modified="2014-11-26" version="1">MSKLFGARGRRTLQQKRVYDQLKNTTIQDAFPHIAACWVGPCWGSVMQTPCNVSPVCMKMAVWRCSSCLQEFEMVVGHFVDEGGVCPHCHNPQKRLDNVTLRNAQGELVIKKPQYIKAPRMIHSNYRSVLFTNPHWESLNIQPMLAQRWELVVDELTKSSNGENGTTPDKHLLLASPKIDGIRCMIGYNQKLQEVQFFSRGGIVLECCHGLVPQLLPLFKEDPTLMLDGELFAPECNFEQLNGLVRRLNKKSSPKVMEAQARLLEYFAFDIMYSAQLSSPSAPFDERYQLLKKLIPVCGAKRISNYIHDDAKKKVIRAKHGSVATAANGQAVKIYHVPAAQVHPSDMKDVLDEACSQGFEGVMIRLPKFPYEHGKRSFGLLKYKQMHDAEFKIVGFVPGEGKFKGALGAFICETKDGKLFNTPPKVPYKRRIELWAHRKEFLSKYLTVQYQELSSQNVPRFPIAKAVRGSEDRQDWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SEZ0</accession>
    <name>A0A088SEZ0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PSP1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_301430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701172.1">
        <property type="nucleotide sequence ID" value="XM_010702870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SEZ0"/>
    <dbReference type="GeneID" id="22577196"/>
    <dbReference type="KEGG" id="lpan:LPMP_301430"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300019300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_301430"/>
    <dbReference type="eggNOG" id="ENOG502S78H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273201at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="2">
        <location>
            <begin position="781"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="589"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="604"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="877" mass="93062" checksum="023B432262CC3F98" modified="2014-11-26" version="1">MTPKRRALSACAAVAGNPGDDSAFLSISRTPGHNVTHHPALSSGSSGCRPMQQRQRGLAAPHSTDTSAAAATPNQARQRPSRVARAALLASPLYATSGGVGTATSIRTSDVQPDNGSVSPLPLQSSLLCTPNRDSRSAAAAATVATGTRAPLDTSTCLEEIPLFLNSFESSSESPTRDAVAVGGYSATQTTPYRTYDLQRAVEEMLRNCLDSFTPAKGSDRNEATPYGSRRGAAQWRQAAPFNAYAGLESLFSPSTVGAGRRDGSSIWAPAMPECTPDRLTVLQGAFAESDGEEVLTTPRSDRASCGIPSAGVRRDPMVYFSTAAVAVVDSSESPRGVKHDNEVGVESIGNLSSGRGGCGAAAESMSQHSSSARSGFEYNCHDGSSSGPDVLTMLAAAVQQQHPEHHHRNTETRPPSARSIMGSMGLGSRTILERDVTGTRQQQSMKPPPSYDITAHHHKPLHHDSYAHPGYSSASSCTATRYALPPPRPSHRLPHVKAAAGSLIAVGGRRVPVDKLHLLSIGDEPPVGQAAAEASLRGGPKSRSQQLSSPLRHVEGPSMRRVPKASLVTVTLAGTAGQEETAVPVAPGRHASAPANRHDAPFPESSASSNVSEAAPARVAVTGPSARRVPPAMATQRRCSSGGAAAGVASLNSALDGEGVRKSSELDVVAVLQFPKGQTMRFLTNLSPTALETAKSAVTRDRARSKRFTAGTATSVLASKTLLRSVEVGKTYLAHVYTQGSPHKSVSYEDVGVCVQLITSTSPLYTAQLGCMDGILLRKVDVFMHDEDRRQHERVLQQQTTAYIECERQFKFSNLPFQLESIYFTFDGSVCIIFYRVVGVANWPSSTCALYCHPNTSRVIRELQFHLNCRVFLKQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SF87</accession>
    <name>A0A088SF87_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_302540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701277.1">
        <property type="nucleotide sequence ID" value="XM_010702975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SF87"/>
    <dbReference type="GeneID" id="22577307"/>
    <dbReference type="KEGG" id="lpan:LPMP_302540"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300030100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_302540"/>
    <dbReference type="eggNOG" id="ENOG502SAZ3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267890at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="627"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="737" mass="79877" checksum="1397D7B09C9AA91F" modified="2014-11-26" version="1">MSSLSPCAESYVCHVTDKPKGQPQRLPGYPQEEHNANLNTSKTEILSYLSVSSHAPASELKGSGVENASTNGSGSSGEAPAVSILGTEGMTPVATSEPAVRTTMTTEALLVFPPQPLPAEEQVPPVYAEAEEAGGKAAERVTHMSAEELSSSDRGGMAAPVKPFTGATTSSERISAVEGGSPGIPVAPCCSSDPTQGPAVSNSLAEAASRLTERENDRSRVLLGPISNAYVRGYTLSQTASSSSPRSPPAHLVVHRCTPERSTGPMWGTTPVSPPGAVQCEKLVHLPVGSKKKYELLSGSSRTTPRGATSSVPALIFTSRSMPASTHAPIVSSMTGSTTAMVVVPTEASLQAAHPSEDTMKDLVSHLDRHSFGFHLREMFQRADFAGMHCEVRRGVRESTALQEYRRLFRVLAKNKDSMSVEDLHELLLIFTPCGVSLREGADFLWENCGGKSSLTFRDFLQYGPALRARLQDYEVFERLPIQQKLITTHARVLPGVSPSTANPARLQLLRVAEQQVQGQLPRHTRPLRLYEEIFLVDYQQRLHDAALIPASDVPPQRLKSDYAHEYGQQQYTRALPPLPQLSVPVLMKEDMVWCHTEAVCSPDSDASEAARHAAAVEKPATVLHGKSEHQAVSRNNRLADATKAPGKAGNRTASKKKNGQGRERVCAASSMGAGATYGDSSRQTGLVLERSAVVVQQQPRPQEQKKMGRFVEEEYWERRIMDDHLITQLQSMYRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SFK1</accession>
    <name>A0A088SFK1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">40S ribosomal protein S14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_303550</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701377.1">
        <property type="nucleotide sequence ID" value="XM_010703075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SFK1"/>
    <dbReference type="GeneID" id="22577408"/>
    <dbReference type="KEGG" id="lpan:LPMP_303550"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300040400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_303550"/>
    <dbReference type="eggNOG" id="KOG0407">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="261250at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.80:FF:000002">
        <property type="entry name" value="40S ribosomal protein S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_uS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_uS11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007176">
        <property type="entry name" value="PRK09607.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO00577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="144" mass="15681" checksum="B66103051DFB422F" modified="2014-11-26" version="1">MSKKQEVKEYGPNVKKGELVYGVVHIFASFNDTFVHVTDMSGRETYVKVTGGMKVKADRDESSPYAAMMAAQDVVSRCKECGINALHVKMRAVGGVRTKSPGPGAQAALRALARAGMKIGRIEDVTPIPTDSTRRKGSRRGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SGA3</accession>
    <name>A0A088SGA3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_312620</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701647.1">
        <property type="nucleotide sequence ID" value="XM_010703345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SGA3"/>
    <dbReference type="GeneID" id="22577688"/>
    <dbReference type="KEGG" id="lpan:LPMP_312620"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310034100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_312620"/>
    <dbReference type="eggNOG" id="ENOG502SIV7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2573941at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="17"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO00847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="312" mass="34374" checksum="55D1DAAF54F36724" modified="2014-11-26" version="1">MSHNVRPSRYAVSQSKARIFVGQLEPYVTEQDLYPVFSCYGKILHLNIVRHSTTVTPNEERRIPTAFVWYETTTEADAAIAALHNVFTFSSPDEEENKVRYIQVSYADKSPECTPWGRWQKTQAEIMRRTNPSGTGTGSNNMPGQYTHVTSGSTSAYSSPALNTGGRFTVSASGPAIRSSQSSGDIVSMRYPRNASRGPLPLTSHIDHTEAQYYSSYDNLYSLGHRSQLYSVGSAVNNMMGYAKHTGMPPDRSISSGDLTRGSTSSFWNVAGEMKSPLADPSRFRHTARYTVPEPDEDLIMAAPSFTVTSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SHD5</accession>
    <name>A0A088SHD5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_323380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702022.1">
        <property type="nucleotide sequence ID" value="XM_010703720.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22578079"/>
    <dbReference type="KEGG" id="lpan:LPMP_323380"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320040300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_323380"/>
    <dbReference type="eggNOG" id="ENOG502RZPN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="241957at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="17"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="421"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="852"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1284"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="320"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="432"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1284"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1300"/>
            <end position="1316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1316" mass="143231" checksum="22151AD2C048904A" modified="2014-11-26" version="1">MSEVLLKQLQQVLAPWDSLPDKDNLDEGGGVVSSLWTPPSPPSPSAQNRDPSSSTSPSPLQLAPKCPSVEWPVEGAANAYVEHSRVATTKLELARAALALFASNAGVYRPFLVRLLRFLFDHVDELRQEQGQLRMDWWMRQQGLGSSTAKTAGGGGGELEGATPEEQNAVAAAYEKVRATESRMAALVEEAAVQRDHFKSQMEMQKRHQHHLEDLLRHQMEMTQMLLDHRLRQDLISGKQSAAVTLVTAVTHSFQGNRSVVGASLGVDGGDDSHETHEASNPAKAAALTTRDILGLECYQAPIRPPERRDAAYVQRLISRAEKELLLERTEDQLRELRAQHEAMQDRIQSLLKLNSRYARQSVELSARLSILHEHNVALATDVHLFQRDYLREQQRTERLQRDLQGARGTVLTMLQVQFGQQETSKEDRSELQQAETTGSHLSATDNGSDTRMHYAFETAAHVAPAATTVVTDPEEMAPALGCKVMRSEEKHVTLATEDHAQEALHLASGKGLCNQLQGLLRASDPQHANVKASLLQFLHLRGDAGLQGSRNGNNDFFFSSSPRAQGWLSPASVPQWVPPYGLRSDVPLQLRSRTSVPLLQLHPIVAEAFVHELLSQRQELLWFSQQQLKERQAVLRATDGRACHRRGSRRASTTMAAAVLTSFQEYIGLFVLVVLLNRSDYYTYRLSPAARTRLDEDARAGQGSRGGFVCQTATHGNPARDSGVAPQPRDQGIVCTSLWDLRHILCTMRTADMEQLPVEGLQLTYALDRASLQLSAGPLTYAYGLASRGTVCDVLFDLLRAERFVFVELCRAVEADLLAKTQAEQERWAEALRQDRPIHVVRSKDPQLHGADQAAAALPSPPAGRRSSTPLRGRIPVAQVARILLAMYPGYSTTIMEQLIRTAVADGTNAAENSVILFYEVLLPSRMLPGPTASSMSIDPSMAVGTSFASLFYTAICDDALESMQMVEDSVCGFARGQPQSSGMSALLSTGAVAVTSGATTATAQQLTSLAFLGVPRVEAQCWGPFLRSAIYRWPLLRATVADGPLEVLSTPANDAALGEDAGTTGKGPALLDDKIVAMVAVAGTSGRSSPASSIVFPAVTPSLRPTLDLSSAEDAKAAAEVSSVARVSVEEVVPYLRQHLLLRRGLYDWAAGTAAAAAPVDISPPSAEEESQATPIALKKVVAESARGASTTGTKERAHDWSAAHGDLLQYWDAQWAQFSGVTAASPSPFVGPTEPAELKHMLKQIDPHRACAWGSELLSSENSLMHPVTYAWEKGDLVIHEPPARDEDDSGGDRHSVMNRKPKKGRKHSAGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SHP4</accession>
    <name>A0A088SHP4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein mS41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_330640</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS41 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702157.1">
        <property type="nucleotide sequence ID" value="XM_010703855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SHP4"/>
    <dbReference type="GeneID" id="22578217"/>
    <dbReference type="KEGG" id="lpan:LPMP_330640"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330011100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_330640"/>
    <dbReference type="eggNOG" id="ENOG502RX8V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268494at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039603">
        <property type="entry name" value="Ribosomal_mS41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019083">
        <property type="entry name" value="SAM_Ribosomal_mS41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28235">
        <property type="entry name" value="PROTEIN FYV4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28235:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09597">
        <property type="entry name" value="SAM_Ribosomal_mS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01238">
        <property type="entry name" value="IGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small ribosomal subunit protein mS41 SAM" evidence="5">
        <location>
            <begin position="55"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO01357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="190" mass="22344" checksum="38ACC544A7D5E5F6" modified="2014-11-26" version="1">MRYTTRVLDQTTGPHKAYKYTYMPDPRKLAPIETSMRSEVLPVVIRPPTSYVPNHEVFLEKVDVHRLAPTSDFKATFKDWNDLMTCSKRELRTRGVPLLTRRAIRAAVLAFQNGNPPERFDTKEEWLYYKQFKTKDYSYRIVPELPEKYRPHQNGIDQAPVPNYNEINQMPEWAVKEEKRLAEKSGAARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SJH1</accession>
    <name>A0A088SJH1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_343410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702767.1">
        <property type="nucleotide sequence ID" value="XM_010704465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SJH1"/>
    <dbReference type="GeneID" id="22578846"/>
    <dbReference type="KEGG" id="lpan:LPMP_343410"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340040900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_343410"/>
    <dbReference type="eggNOG" id="ENOG502S9JF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="245890at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="710"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="710"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="734"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="748" mass="80580" checksum="79B6C1CB8887A0D6" modified="2014-11-26" version="1">MSHYIEACRDDERFTARLEEATKEMGGLLLKTSRTRHELDRMAAEVRMRGPLHFYPCNIADCVDLAPSTFAGERLAPPQVRDDLARNMLSAELAQWARWHLPSLVAPLIEAQVQQRLLSLRDSVDELRVRQAKVEKAAKDATERVHVHRADIHADFAASQEEMQRDLEEHQRGVKRQIAAWSEELRHVREDVLALGQQRVSASDRQEQRISGALQRQQTHVQETLEALEHGLQRWRRAMSRAVQKETQELHAQHRVLENRVAQAQGMLTSTADMAARCTAETRRLMEDAMCRSSEVRVCRRDVNRLEMLVQCSSLQTALLTGGAGSSDSNDSSTAPAAASVVLNGLTQEMARFSDSLHAMVHRVDGLDRHVRQLEMAVARSTAVSCGQGTYHSSMRGVDEESSYGRSFASTSRPSCSYLSKATGLRGRCASAGEARAPSPLAQNDSSDVAPIHNGGAAAKPRTTSITLVSATQPVGMGSALGGGHYRTAGPEVQLTLTPLMSASPSSTTYHLPASHLSGSSLRFEDEAGDSHSTPVIVSDARPAPDVEGDRVLLRSAAAGTGVQQPLERRATAHATPAKTVEGDTQLGGVAKPTAAKTVAHGMPLPLAAVDASQIARQDVAPSLTHQYDASSWPAASALSAGNADVTYLVKRPSSCLATCEAVAVAEDVALKRQSGSDHAERPVVATPCSPVDSYLSDTPAADLYNSKANVASAPKSSTPEIAQYTPAQASDSESERDNHVIARSALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SKI9</accession>
    <name>A0A088SKI9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-ketoglutarate-dependent dioxygenase AlkB-like, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_352050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703142.1">
        <property type="nucleotide sequence ID" value="XM_010704840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SKI9"/>
    <dbReference type="GeneID" id="22579234"/>
    <dbReference type="KEGG" id="lpan:LPMP_352050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_352050"/>
    <dbReference type="eggNOG" id="KOG3959">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="442860at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032451">
        <property type="term" value="F:demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070988">
        <property type="term" value="P:demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.590:FF:000026">
        <property type="entry name" value="2OG-Fe(II) oxygenase superfamily, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032857">
        <property type="entry name" value="ALKBH4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12463:SF1">
        <property type="entry name" value="2-OXOGLUTARATE AND FE-DEPENDENT OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12463">
        <property type="entry name" value="OXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="1">
        <location>
            <begin position="182"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="297" mass="33306" checksum="73E0B29C0F848E54" modified="2014-11-26" version="1">MEEHSSPCVCSGIRFCAKCRDTLRVQQLFSGSVFLSSASSVIEKQWHNDRLSSCSFAIIGKSTLSYCIECMTIFKSEAPIKSCVDHQGAISTSVVISGLVVFQDVLTEEEETALIYYLDNSHPFPPWKESQSGRRKQDYGPKRNFKKKKVRPAEIPAMPLALEPVCATISSTTENFTGRAYRIAEVSALEYVEGKMSNFDPHIDDTWLWGDRIAGLNLNEPCVVTFVEPDGVCCDVYLPRRSFFLMSGNCRYKWMHGIRPEHVRGRRISLTFRELSDEILADAGTSEVVLSAASTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4R3</accession>
    <name>A0AC62A4R3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">60S ribosomal subunit protein L31, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3420280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="XUY36792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="188" mass="21372" checksum="38F860B5939EF219" modified="2026-01-28" version="1">MTRAGMKGKVLGKEKKTAIIDARKKAVESRRSRDDKRWKRVIARMDEEKRKRFHGVGNTAKNSRARGTTRASLRKRTGRKPDAVSMEATIHLSKLLKKKTFAKRAPLAIKRIKAFVGRLMKTKDNRIDASLNTYIWHKGVKGVPGRVRVLIQRKSETAEGNKHKHFFTVISNVPVASFKGLTTKTVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A516</accession>
    <name>A0AC62A516_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Vacuolar ATP synthase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2120090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="XUY36879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="187" mass="18872" checksum="E6C9C2F9A6A2B450" modified="2026-01-28" version="1">MKCQIASVVAAVALFGSAAAVSCSDKYPQSSAFFGSMGCASALIFANLGSAYGTAKSGVGVAHLGILHADRIMRGIVPVVMAGILGIYGLIVAVIINNNIKVEDNSYSSFAGYLHFGAGLAAGLSSLAAGLSIGIAGDASARAYGKQEKIFVAMILMLIFAEALGLYGLIIALLMNNTAGKVTAGCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5A4</accession>
    <name>A0AC62A5A4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucose transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3520350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="XUY36868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="559" mass="60283" checksum="888C26B6B67E74D2" modified="2026-01-28" version="1">MSSKLQANDHPSDSISEKEPARDDLKKSIDDQSDAPPFLSASNAKVILVQAIGASLNGYSIGFVGVYATLFGYSTNCASFNSEQGCVTVPNADCKWFTNTNSTPFCGWTDITCRRTYTYTNLSGMPAAITQCEADPRCRWSYSSQECQNPVGFSSAESGIFAGSMIAGCLIGSMFAGPLASTIGARLSFLLVGLVGVVSSVLYHVSCAENEFWVLIVGRFVIGLFLGVIGVACPVYTDQNAHPKWKRTIGVMFQVFTTLGIFVAAAMGLALGQSISFDQNKDQMVMARMQGLCAFSTLFSLLTILLGIVMSESRAQFGGGEEGAIELDPNEYGYLEMIPRLLMGCVMAGTLQLTGINAVMNYAPTIMGSLGLAPLVGNFVVMLWNFVTTLASIPLSYVFTMRQLFLFGSIFTSCMCLFMCGIPVYPGVSKKLEVKNGVAITGILLFILGFEVCVGPCYYVLTQDMFPASFRPRGASVIQVAQFIFNLIINVCYPIATESISGGPSGNQDKGQAVAFIFFGCLGIICFVIQVFFLHPWDEERDGKKKAAAPAYGKREVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5B6</accession>
    <name>A0AC62A5B6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Beta-tubulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2120100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="XUY36880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="443" mass="49757" checksum="1E1DE6BB7C45CA0D" modified="2026-01-28" version="1">MREIVSCQAGQCGNQIGSKFWEVIADEHGVDPTGSYQGDSDLQLERMNVYFDESAGGRYVPRAVLMDLEPGTMDSVRAGPYGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELIDSVLDVCRKEAESCDCLQGFQLSHSLGGGTGSGMGTLLISKLREEYPDRIMMTFSVIPSPRVSDTVVEPYNTTLSVHQLVENSDESMCIDNEALYDICFRTLKLTTPTFGDLNHLVAAVMSGVTCCLRFPGQLNSDLRKLAVNLVPFPRLHFFMMGFAPLTSRGSQQYRGLSVAELTQQMFDAKNMMQAADPRHGRYLTASALFRGRMSTKEVDEQMLNVQNKNSSYFIEWIPNNIKSSICDIPPKGLKMSVTFIGNNTCIQEMFRRVGEQFTGMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATVEEEGEYEEEQEAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5W5</accession>
    <name>A0AC62A5W5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amastin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2020280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="212" mass="23608" checksum="90C39507A3D743F4" modified="2026-01-28" version="1">MSKFSSDNSQESNVTGSESTETTEKHSTDSDLQVSLVEGRIGLIVYVFVQFFAFFFVLFGTPIDMFRLIGSSSSPSEAIVTTLWGSKKGLFSSGYGLEFTRQWRTCPNRLTRFRVAQAFALISIFVYGAAFVLGVIQLFCCAYLRWVCLALNVVGAVTLCIVWAAMVVTFYTNESFICAEQGRLYTYGSGFVLFVLAWILDIINIVSLLLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5Z4</accession>
    <name>A0AC62A5Z4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Elongation factor 1-alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1720160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="XUY37106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="449" mass="49058" checksum="C7CA18E3C4A6A3F4" modified="2026-01-28" version="1">MGKDKVHMNLVVVGHVDAGKSTATGHLIYKCGGIDKRTIEKFEKEAAEMGKASFKYAWVLDKLKAERERGITIDIALWKFESPKSVFTIIDAPGHRDFIKNMITGTSQADAAILMIDSTQGGFEAGISKDGQTREHALLAFTLGVKQMVVCCNKMDDKTVQYSQSRYEEISKEVGAYLKRVGYNPEKVRFIPISGWQGDNMIDKSESMAWYKGPTLLDALDMLEAPVRPVDKPLRLPLQDVYKIGGIGTVPVGRVETGIMKPGDVVTFAPANVTTEVKSIEMHHEQLAEAVPGDNVGFNVKNVSVKDIRRGNVCGNSKNDPPKEAADFTAQVIVLNHPGQISNGYAPVLDCHTSHIACRFADIESKIDRRSGKELEKNPKAIKSGDAAIVKMVPQKPMCVEVFNDYPPLGRFAVRDMRQTVAVGIIKAVSKKDGSAGKVTKAAAKAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A619</accession>
    <name>A0AC62A619_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amastin-like surface protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2021130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="195" mass="21821" checksum="4422187F17640540" modified="2026-01-28" version="1">MEFNPFIIVYAAIQFIAFLLVLVGTPLDIFRSRQRSIFNETSCVLLWGVKRNCSSIAYAATSDDRWVMCPTRRTHFRVARVFAVITIGVYCAAFVLGFIMLCCYACLRWVCLGLNIVGFVTLATLCALMVVSYETDAYPLCPKLKNDFTLSSGFFLFAAALCLDLVSIAFLFIPWSHENVEGSSSHSKEGNSQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6K6</accession>
    <name>A0AC62A6K6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATG8/AUT7/APG8/PAZ2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0920160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="XUY37333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="124" mass="12747" checksum="547644016555283B" modified="2026-01-28" version="1">MSAYVSSTPLEARVARCASLRATNAVPVVVEEAQARGGKAHFSALPRETTAAQLVAAVRAFRGVAANKPVTLTVAGCSVSPSATLGELHDACKQADDGMLYVAYTAERSMGAAVCTPCASCSWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6P2</accession>
    <name>A0AC62A6P2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Leishmanolysin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">GP63-2</name>
        <name evidence="1" type="ORF">LPMP_1020090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="XUY37361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="750" mass="82084" checksum="FF2AB9E447FEDDBB" modified="2026-01-28" version="1">MDVSQRRRRRARASAPWPAVVRFLLATSQRVTLSPAQHASAGRPRLRHSPSSDTRPIRGWKGQPEGVGPRLFARGRRLPLRCAGGRSVRGTSPLLPSRTLRPSLFLRLPPSSLPRPRCPQHHRPPPPIAAQRPSALTPPPTLPPAHVLAGVTGPLARTRSTTDTASMSRDRSSTHRRRSVAARLMRLAAAGLVMAVGAAAVWAQAAGHHCIHDRLQARVLQSVAQQRRPPGSVSALGLPYVSTGPISSAHTVDWALDDSTSPSVAHSADWDTMRIYVSYADLTDPDYYCSYVGQLIDNHDGAIDICEAEDILTDAKRDILVNVLLRQALQLHVERLKVRRVQGSWKVTGMEGDVCGEFKVPEAHVTVGVSNTDFVLYVASVPSEPGVMAWAVICQVFTDGRPAVGVVNIPAAHIRSAYDQIMLRSVAHEVAHALGFDLTLFDELELGDEVSDLRGREYYVPVLNSPTVVAKAREQFSCPTLEYLELEDTGSPGSAGSHIKMSNAKDELMAPSVTAGYYSALTMAVLQDLGFYQVDFTKAEVMPWAHLASCDFITKKCMERNITQWPWMFCNTTDVVLQCPTDRLAVATCKITHHEKPLPLYFQYFTDHSLSGDSTLMDYCPYVDTYPDSACDQDPSTAPEIFKEFNLFSDASRCLDGTFRPKHSTGLSEQYNALCANVKCDRAHRTYSVQVYGSSGYVACTPGQRVELATTSAAFVEGSYITCPPYVEVCQANIKGVINFEGDAADTAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHB1</accession>
    <name>A0A088RHB1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_030280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009372">
        <property type="protein sequence ID" value="AIN95263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700971.1">
        <property type="nucleotide sequence ID" value="XM_010702669.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A088RHB1"/>
    <dbReference type="GeneID" id="22571894"/>
    <dbReference type="KEGG" id="lpan:LPMP_030280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_030007700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_030280"/>
    <dbReference type="eggNOG" id="ENOG502SMN4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268019at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="668"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="959"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1023"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1091"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1274"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1696"/>
            <end position="1872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="425"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="495"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="521"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="668"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="969"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1059"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1110"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1696"/>
            <end position="1741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1794"/>
            <end position="1805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1817"/>
            <end position="1828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1903" mass="197201" checksum="68C9A558430F694E" modified="2014-11-26" version="1">MPASTASSCLTYPLNAADAAAITTDGGSDNDASTPPSAVLATAEVNGTDKPIELGGRWTAVRDTRDERAPPRVTGTVKSETALANLLALCLDRIHRLEERQARGEALQNRLDTSLHAPLTQAHREQQQQQQQQQQSSGPAAVEEHRAHGAGDANSSEAYDGECNEPYHRSRQTTNNSHNNCDRATAAATSTAALKSHSQQRRRQHGADEPAYSLGSPTPADAAAPTASTSGKGREEDDALTKNGAGSQHHHHESLGAVPSLSPASLANTKWKEVSSGAGAGIGGGCARAIFSTTSSSSHCNTLTASVVVASDSTNEPPMVSHLGASLGVCRLRQSSLVTVLRPTHTSQAEAHAIAAAADTLSTPVQVSSGNATAASTLISAGVSSTPASATPMSGLAWAVPMVLLSSSENSCCSTPVEFHMSIRPPSQQQQHSPTQPSAEEERPSCLSGPLAERAVEAAYDRPDVTSSAHQEQQRGSRQHLRSPLTQVPPLIDHPQQQQAQLHPQTLHRNSEECEARESASSRVSPTATRGSGSTTASSAAYTGAELDAFYQALSTPRPGTPFFTSSGSAAATGSRATVTAPRKVPFPPGTDNTTAINELFAQTVLNTMDVTSIKENFTTLVHSVHEEQEKRHRFQRRVGSAVKELFRRVLAMSSMVSRLQRRVRQLESGAGSDGAAEAADWHHHHSSHRERRGTDNNRSAGVSDQNEDGATFDGDIDNSGSERHERFCASLSTASVATSRSRRASSYRRSIGDRSGNARYAVVAVPFSSSGSLSVGCERVPPAGRSPRLSSLTTQCLTGVARGEAMRSRGGAATTGTATNTPAVDGVDIAWMAPATVTPCVSAATGASVGPLPLAGSTVPPKMISSSTSLHSSITNTTTATTTTTSRAASAMLVPQSVVSSLASAPQQERTPLPLWLPPMMLDANTTASRSGAVTNKSPIVPSLSITDARLDMTSSLHASTTEDERAAPAAATATGRGSAGTCAESANSWATPDGNGGGSDRAWQPPEVYTKHHDNEKVTETLEEQSRIALPPQQQQRRRDLFGGPSAPSPVPPSTSSRRRRHKRNVHQAASTARAVTVVPIPIVSGSQHSFPSARHLSVPLPPPPPTTTTTSSRTSPACASAGTSSAAAAAATAGQAPPNIQLTPEKAAACHSSSGTTGVASQRLFNALHSEHRGGAVAEVRTALDAAAEVSDGCLKSTPRVGVRGGRSVVCATHQSDGSATDVGNTETTAIADSPAASSASCVSPHTLTGSVASLARCASSAATATTLARLANKPATAGPRQRQQRRGASMAKEPPGWRQARQPRGAFISSLAATPRSDAARRSNVGENTCSTYAKREDKNEAAEVELMDTAGGIPLQSCASLPTWRNAAISASPTHSSSDRSRSLHPQRSLLSSWLQSPPVRVATAAGGDDKTILRSPATPASITAILAGGEGLCQCSAGPHQSHSSSGSFVSTPQRWLNAQLGHSLAPATAVGAEGMSFSSPRERLSPMQPVHPVAVAHHPQQQQLLQTTATAHQARKWTSTRLLSSATVSGVLPSVPLAASAQSASNVFRTRAIPLSPSMAHPASVASPVVTDISASPAVGGTDGSGVTAGHLSARLAQPMSPLSSTSRLKQCHHPHPTQVLHLSTSTSSSNTMSTSLAAPYTLPPMLPQDHPPKLAYAQSDDASVLSQHAVVRPRSAAAAALMQTANTLPSGVVSPPSSSWSPRLTPLSTSRLTKPVSSAAASAMSVSSKSMRSGYEAETSARAPVTPDGKTQKPSNAAKVSGKGAQGLSSSPPTGCDGKAAARRVVTQQPKPRSSSLLAHGPCLSPLKRTPDPSHLHERWLQTPSSTRARGSSRRPRAGLPPPLSVETLSDASGSAPPVPNVGTTQMTYVDRDTAKGDIGHGGGQLCCTGDTLHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHV5</accession>
    <name>A0A088RHV5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-fructofuranosidase, putative</fullName>
            <ecNumber evidence="5">3.2.1.26</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_040280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.26" evidence="5"/>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="AIN95355.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703677.1">
        <property type="nucleotide sequence ID" value="XM_010705375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHV5"/>
    <dbReference type="GeneID" id="22571987"/>
    <dbReference type="KEGG" id="lpan:LPMP_040280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040008600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_040280"/>
    <dbReference type="eggNOG" id="KOG0228">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277998at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004564">
        <property type="term" value="F:beta-fructofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18624">
        <property type="entry name" value="GH32_Fruct1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050551">
        <property type="entry name" value="Fructan_Metab_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018053">
        <property type="entry name" value="Glyco_hydro_32_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31953">
        <property type="entry name" value="BETA-FRUCTOFURANOSIDASE, INSOLUBLE ISOENZYME CWINV1-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00609">
        <property type="entry name" value="GLYCOSYL_HYDROL_F32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN95355.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="641" mass="72025" checksum="C55EFDC59986105A" modified="2026-01-28" version="2">MTAALVRRKVILLLVAVAMIAAAAVAMDGVPYEPIYHIRPPKNWINDPNGPYRDPVTGKIHLYMQYNPNGPLWGDIAWYHVTSEDYVKWTRPESPVAMWADRWYDRWGVYSGTMMNNNYSEPVIVYTCTEPENIQRQCIANPPKSDLHGKRTLDTLVKSPLNAIMSEDMIPGLVALENFRDPTEWWLDPTHPNRWLIGFVARIKDSEGDNAHVILFSTEDPSFQSGYSFSHSLYTYKYDLDRMFECPDFFTLTQGGEHYLKLSTMPSHRDYFVYGAYQADPVTGKYIFVEDPERSFTFVDYGPLYASKTFYDPILNRRTMWGWTMDELSDTQVRANGWSGVQNMLRTVVYDTVEQKIKTQPVPETKGLRLHKLVDMKGIAVTQTPTQIVASNTNNTLYHEIIARFTLADPATFAADATYADDSEVPEVGVMVRANASLGQYTTVSVRMPTGGPSPSESTQQLETYPAIKVFSTPTAASCSAECNKMRLCESYTFRESDKNCTMYWKTNPMGTSADATSGTVREPLLYLGRTQSGTIGNTAPLHGRAPFATATPNGFELHIFVDDSVLEVFKDEGLETLTGRLYIDNGADTTGVAVYARNAGTVTVDIEVYTMDTIWKAPTPNAARNFTNSLYNLLDTLIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RI17</accession>
    <name>A0A088RI17_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_041020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="AIN95425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703747.1">
        <property type="nucleotide sequence ID" value="XM_010705445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RI17"/>
    <dbReference type="GeneID" id="22572061"/>
    <dbReference type="KEGG" id="lpan:LPMP_041020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040017400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_041020"/>
    <dbReference type="eggNOG" id="ENOG502SFRU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272803at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN95425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="140" mass="15305" checksum="F9140DE9D7DB7E61" modified="2014-11-26" version="1">MWLLSSVAARTRSSSALTSPLWPMNGDGNASLPLECRLIRVSKEDISHVTADDIKRVRARLTNDELTTSLRLLVETNRFADVLASASSSAWAEAATGVTEVHMGLSGNVMRDRLSLLYSMLPYVSDNFLLAMGNSYSPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJ91</accession>
    <name>A0A088RJ91_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_020090</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CP009371">
        <property type="protein sequence ID" value="AIN95189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698154.1">
        <property type="nucleotide sequence ID" value="XM_010699852.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22571819"/>
    <dbReference type="KEGG" id="lpan:LPMP_020090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_020005900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_020090"/>
    <dbReference type="eggNOG" id="KOG0892">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05171">
        <property type="entry name" value="PIKKc_ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000041">
        <property type="entry name" value="Putative phosphatidylinositol kinase related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038980">
        <property type="entry name" value="ATM_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044107">
        <property type="entry name" value="PIKKc_ATM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079:SF4">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="11">
        <location>
            <begin position="4556"/>
            <end position="4872"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="12">
        <location>
            <begin position="4897"/>
            <end position="4929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="204"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="661"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="746"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1069"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2119"/>
            <end position="2155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2413"/>
            <end position="2433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2674"/>
            <end position="2706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2750"/>
            <end position="2777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="4847"/>
            <end position="4879"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="4258"/>
            <end position="4285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="687"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1082"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="2421"/>
            <end position="2432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="2674"/>
            <end position="2685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="2693"/>
            <end position="2705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIN95189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="4929" mass="527790" checksum="0C13D93C3E4A2816" modified="2014-11-26" version="1">[encoded data, 4929 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJA4</accession>
    <name>A0A088RJA4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribonuclease Z</fullName>
            <ecNumber evidence="4">3.1.26.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_080770</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase Z family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="4"/>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="AIN95885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704207.1">
        <property type="nucleotide sequence ID" value="XM_010705905.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22572539"/>
    <dbReference type="KEGG" id="lpan:LPMP_080770"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000033700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_080770"/>
    <dbReference type="eggNOG" id="KOG2121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="527344at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990180">
        <property type="term" value="P:mitochondrial tRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047151">
        <property type="entry name" value="RNZ2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553:SF49">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="574"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="791"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="852"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="944"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1048"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1263"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1300"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1536"/>
            <end position="1599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1950"/>
            <end position="2018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="201"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="581"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="791"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="852"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1048"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1075"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1302"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1557"/>
            <end position="1572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1968"/>
            <end position="1987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1988"/>
            <end position="2002"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN95885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2087" mass="219386" checksum="4439E5D227A6DBB5" modified="2014-11-26" version="1">MSRYIQLLGSDTPNGYGGCCYYGPLDHPALRESTFTCSTGSSSSTGVVPPQASRHIGAVDAEYMLQSGAEVSISAPTLELSVRARAHDTLHQPSPTKEAAESAVSPLRNYSSYLAAKRPTWPRAGLLHPSTLLHPRSPSPSVSPSAVAAASAPHVTGDAGLSGGEGYIFFNCPEGTQRFSSEANIKLKKVRGFFFTRWSSTGASASPSTSATIAGSAEDEQHRSASADSVADSAHATMLEGPVGAASAVMGLPGMLFTINDAGVRHATFFGPSVALDGPQQLACIDDLTPASVRNGDGGSKPHNTSAHTHAHVCTFSCACDSVATSSTGRSTVAAAGAQQSPPLPSTGLRGFLTALRFHYFQYRPMIFRQLHGVVRKATDEAVGCSHGDTLASMTATAGNNQLYFVETVGEPTMLHGSREGGPLADASPFVHATLPLSSQSLLVAFRVSGGHRNGEKASATAAAAASDVMLSLSQPASPPTMTEGEQWRHLHSSVLTEGRNERTVAGASASTVSFTAPTSHDVVFGYAIIVAPGSSFDAAKACALGVRSGPKYGQLKLGMCVEADMVVDAVDRSVGPMPPSQNASASRGHVSGQSPTPTQRWVYPHQVMRPTAATKHAYISLVLDGDRPEDVREALTRLLGSSFRESVGLPEKGSAAACEEAAENDDACRNTAVGEHGGGVLQRLLREHFPHLAYYYEEEEEVGEGVTAAPPHSQKPRWSRRPRQLAVRHVVHVQPTSYFAEFEHRCRPSALPCSSRHEAGAPSVYAAYNAYIFSDVAGQHDPLHQHRHVCRSEGHREEEAVAEKAERGSDAVVPTDALLSSRQKSSRSLPAVQLSLTPSLSFTLHDMAEDADDDAGMGEEGECESSSKPTGEAHRRHSPQLLHGCPPAARLPRRTTWHLFTSYVQRHFTAFPTALVHRYHLHHLAPSLFPIVGATALAKRTGGADHVSENGTARSGVAGESTSSAEASDSGGAVRTQRAKTSASDLSITSADDSVVYWPYSLKLRCVPEAAVQLFCRNQGAEKKKTIQVQQRTELAGSLRLVPSAVNASSGHATAGVTSSSRPLPTPRKRERQTSSSPDTPSATACRARASASASTATAAKPRELTPPLPPSAAARTRPPSAPPRHVAVVDGVASLLPYPTPASALALLSATFLRSLKTNSAAATRTGSASVAASTSTERHMNRDDSFEALQQAVDMASTGTSGIGGGALGFLGTGSAVPSKYRNVSGTFLELHLPSYCFPGRGCPAKRLFHEDDRVNASETASVVAEDTPSATRARPPAGEAACPWGGDDVLLDVHSTNSSARSHAPAAARIDGSQPAVPPRLPSTPMSLGFQQLRRGVVILDFGEGSTGQLASLCGHLRGGGACSHRSPCCSLSTSPLHCALGGHQESGRDRCKGAGDHGEDAGSNALSLHTASAAGFTEMEDDADKRLGEFVLDIILVFISHAHADHHLGLMSLLTLRHQYLQRGQSALPSVPKLLVVCPTEVYAFMMDTWGGTAPYRTWLHEECVFDLMPPPASALHSKGVLSGVLAREEGGAAPHGRQQKPHAVAPVADNSTRDSADGTEPERDSVDGGDVDPGRAASFTHRCPHRHRPTLHSSDYQPEQQHVVPMRLLQAHLAAWNRAIAVGIRDHQRQPLSDLPLLSSAEPLAATSMTAARRVDGDGDAAAATAAAAALGRDNVWWDAEVITVDHPANAHALLLRFPFCSPVTEAKRQRGVCSEASDGGATCAANPDAAEAATGRQRSAELFSCIPDSSRVLLFSGDTRPSSFLVEQSWAFAASTRNSLPRCSGSFELTDGGGLVTGKADSGRAFEEEEGVVLEAKLHGSGTVGRLQRAALARLPTSLLPSSSTPPSSPSSPVFILVHEATFGPGFEDEAVRKKHSTLPEALRIGAAVQAEYIVLNHFSQRYPKLPGLSKELLGGRSTSLVCQRRTRAFAAVPATSAVTGAGAEHPANLVDDGVGGDNAPRSSDSGEQQRSTGKASSTAPREDGGHTKGDRGAEQTEDSGPPLPPPPADAADAAVSLYANMSFAFDLMSVSFSDMQRGLVSRLTPTLVRLLEEYDSWGIGTTQRIRSGGEGSGGGCPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJC8</accession>
    <name>A0A088RJC8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_081020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="AIN95910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704232.1">
        <property type="nucleotide sequence ID" value="XM_010705930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJC8"/>
    <dbReference type="GeneID" id="22572564"/>
    <dbReference type="KEGG" id="lpan:LPMP_081020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000013600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_081020"/>
    <dbReference type="eggNOG" id="KOG2164">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="302966at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16536">
        <property type="entry name" value="RING-HC_RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039739">
        <property type="entry name" value="MAG2/RNF10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983">
        <property type="entry name" value="RING FINGER 10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="126"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="296"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="482"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN95910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="580" mass="64069" checksum="43E5352DA66440E0" modified="2014-11-26" version="1">MAKSKKGGRRGTVVKNLWDLSDLQAAAPGGSRGSGTHERPSAATTVATYRCPRPVRHVDPAALKRAFMLQNFQFILRSELLTITSTQGLPQGQRRLLECIQLSDSLVPWEVVHSVVMRATPEEYQCPICMEVPTAPRITECGHVYCLPCILQYMSRQKAAGAPRKCPMCHDLLTPYTLRPCVLQPVQPRRVGVQARFDLFKRHRNSCVLRRSEDPFFSSPPPSSEKGVAIHLPAYMEPFSYQSRYVMATPQYEAEQRYADCAGISERLRELGQPLNESDAEVGQFLLEALGEVSKEPKGLPPSMLRNSPPLAPRPATTPEGEDGYLELYADGEGQPYYLHMLTVKMLKHDARLRNAPLPNTVTGTVEEVVTMKQTEETRRIYKVFSHVPLHGMIKLCVVNVDRLVLPETRAAFAAALQKMASDRAQRRHRDDRAAGEDASWKQYLMKYSSRSGIGRGDCWGFSPDTAPSDFSIDTESLPYLKLPSTGSGGSDHGLPPNPLDTRQRATKRQDMQSLLVDTVGAPPPRGDSAAAAFRSLTTNTPSTIAAGCWAQGGAAKLFAKAERKEPTISTWGGHAFTPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJL1</accession>
    <name>A0A088RJL1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_100675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696790.1">
        <property type="nucleotide sequence ID" value="XM_010698488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJL1"/>
    <dbReference type="GeneID" id="22572804"/>
    <dbReference type="KEGG" id="lpan:LPMP_100675"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000027400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_100675"/>
    <dbReference type="eggNOG" id="ENOG502S5ZU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="248506at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="127" mass="14116" checksum="8DE2AE58BC870EE5" modified="2014-11-26" version="1">MSGHHHTSDPNLTQNQGNMLGDRPCVRQSRLYREGCSGNVMKELLGQSELTWKTDQTEGCYGGGHVYDHNTEDHCAAPTQQQQLKQQCQPPQQQQQQQQAVSASTGRGLRPGAGYANRQTYNIFTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJR0</accession>
    <name>A0A088RJR0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_110110</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696860.1">
        <property type="nucleotide sequence ID" value="XM_010698558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJR0"/>
    <dbReference type="GeneID" id="22572876"/>
    <dbReference type="KEGG" id="lpan:LPMP_110110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190007000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_110110"/>
    <dbReference type="eggNOG" id="KOG0600">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001180">
        <property type="entry name" value="Cdc2-related kinase 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF233">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="58"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN96207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="397" mass="44253" checksum="AA94415FB40AAAFF" modified="2014-11-26" version="1">MGGEPDDRNRDVTDDGHSARKRVCLEHMLPSVQQRFAELAHASVGESSLTADALFQRYQRVLKVGEGTFGEVFVLYDTVAHTYITMKRMHTLLSFRRRSLGIHRCTFREVELLAALQHPNIVQVLDYHILSDGSLVLLMPVIAHDLTSLLRRWPSTTQSTGHGTASTTASTHPRMPLHVVKCIFRQIIAGIAYLHRHKVLHRDLKPSNVMVDHTGVVKLIDFGWSRFCAAAGAMTGPPCVTAFRPPEVLVGAHNRYTFSLDMWCCGCVLFEMLTGGTPFAKSRNEAECLANIVDWLGSPSSSSEVYYQSTARCPLPLALGRPNTFAQRCSNYGIKPAESVFLRRMLCLEPGERATAEALLSDAWFTTAPTMCVPSAIPLPAHNMFRLVEVKRKELQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKN1</accession>
    <name>A0A088RKN1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_130690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697151.1">
        <property type="nucleotide sequence ID" value="XM_010698849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKN1"/>
    <dbReference type="GeneID" id="22573179"/>
    <dbReference type="KEGG" id="lpan:LPMP_130690"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130011200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_130690"/>
    <dbReference type="eggNOG" id="ENOG502SGUU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267887at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="233" mass="25244" checksum="2A5E9D5D4B34546B" modified="2014-11-26" version="1">MLRRTGGFLALFSSAGGSAPRSKRPSSDAYTDAAAAESAAAAGVYLPWTARPWAVTYRVHYTQWKFVDTVFAHLATVAPAVLNDRAQEQGVRDVLCELEEPVVALRRQQARQARRLKRQEEALDTDATSSTSQMLASAVQHTATTPTMSPSATPSSGVTADDAAATQTSSTLDSLISKSNTSAEYEAVDSHIVLLNANKKLKDSRKSRKMKDTRKSKKDIHDSVASDVIIYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKP6</accession>
    <name>A0A088RKP6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Actin-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_130840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697166.1">
        <property type="nucleotide sequence ID" value="XM_010698864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKP6"/>
    <dbReference type="GeneID" id="22573194"/>
    <dbReference type="KEGG" id="lpan:LPMP_130840"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130012700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_130840"/>
    <dbReference type="eggNOG" id="KOG0676">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000050">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000366">
        <property type="entry name" value="Putative actin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="247"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="483" mass="52710" checksum="5D7BC3B6A06B49F7" modified="2014-11-26" version="1">MDYNVSNATVVLDCGSCHSRAGFGGEKGPRLDVPTLVGYPRHRSIAMAAGMNEQEVGEEALLKQGSLDVHHPIRDGFINDWGDVEKLWSHLLFNELRVSPETHCFLLTQPVNTPAAQRERTLEIMMETFHAHSLYLGVSQVLSLYTYGLTTGLVVDSGKDITRAVPIHEGYALARHVTQSPVAGAALTRYLGGLLREQGYALGTATEQELLNRAKEDLCYVQPRPHAQRGAAGDFFTSAPGILAGTSPAAAGASSRRGTKLGRETKDSIDSASLATTPTTARGKDTLSESAGDNHREDDGGSSSAVETGVTEDFVLPDGQRIPLTVERYDTVEVLFNYSLLALMDSHGRNDRTYEPRCKVRTDMGDVFHPSFAKGISWLPFAAVNNCEATLRPQLYANMVLAGGSASFPGLKTRLEAEVRQLYRESHPSEAVVPIQVRDMPCRAYSAWLGGSMLSQTTVFQHLVVSRKEYEEEGGRVIHYKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLE2</accession>
    <name>A0A088RLE2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nuclear migration protein nudC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Nuclear distribution protein C homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_140440</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nudC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697278.1">
        <property type="nucleotide sequence ID" value="XM_010698976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLE2"/>
    <dbReference type="GeneID" id="22573311"/>
    <dbReference type="KEGG" id="lpan:LPMP_140440"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140009600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_140440"/>
    <dbReference type="eggNOG" id="KOG2265">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06467">
        <property type="entry name" value="p23_NUDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000001">
        <property type="entry name" value="Nuclear migration protein nudC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037898">
        <property type="entry name" value="NudC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025934">
        <property type="entry name" value="NudC_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356:SF3">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356">
        <property type="entry name" value="NUCLEAR MOVEMENT PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14050">
        <property type="entry name" value="Nudc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="8">
        <location>
            <begin position="164"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN96625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="327" mass="36640" checksum="B61C860FD0AF3046" modified="2014-11-26" version="1">MPDERFDSMLLAIAQQQEGIDGILDTFFSFLSRKTDFFSQPDMARRSVHQVMDRYLAAAEEKQRKAQEAQAAAQQQQSARTSSRVEVLENEEEVNAAAAAQAAKDAAQRKLELEKAQCEVAEAKARKEAAAKEAAQQAETDAKEAFADTADAPRGLPPTAANGFAYEKYIFSQSLQEAEVRVPLPAANVKGKQVNVVITSSRLLVGMKGGSPIVDGELYGKVRAEECMWTIEDGKTVVVTLYKANSMEWWKTIFQGDPEIDLQKVMPENSKLDDLDSDTRQTVEKMMYDQRQKMMGRPTSDEQKKQDMLRKFMEAHPEMDFSQAKFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLG6</accession>
    <name>A0A088RLG6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial ornithine transporter 1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_160220</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN96897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697550.1">
        <property type="nucleotide sequence ID" value="XM_010699248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLG6"/>
    <dbReference type="GeneID" id="22573599"/>
    <dbReference type="KEGG" id="lpan:LPMP_160220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160006900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_160220"/>
    <dbReference type="eggNOG" id="KOG0758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="409586at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF12">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="2"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="159"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="264"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="112"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN96897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="385" mass="42391" checksum="3C8200DD8ACE04A6" modified="2014-11-26" version="1">MMDVIIHLTAGTVAGMTGVLLDYPLDTIKTRMQVSSYTKVPYYYRTTAAAEVASISATSPVTYWQCASQLYQRGGIRSFYRGLSVPLTAQGAEAAVVFSVYNVSLQRFLQKQQQQQRQGQEREKLSGSRGDHKRRSYRQRPTQSKPELPQPPPPPISVWSSPAHWKASACAGLAVSLILTPVEMLKCNMQMESARPSWKRHRTTVFGLARDLVATHGACGLYTGMTGTLTRAVLGNMAYFVSYEQCREWLAQGFAQSPGDGEALPIWHSMLAGGISGCFYWSIAYPADVAKTKMQVCPAARRQGFTRTLSSLYHSGGVEALFRGWGVTVVRAFLSSSVVFTIHERSSSTLQGFSSLYCALARDSAVTSTSSAAYEPQEELVSHRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLQ2</accession>
    <name>A0A088RLQ2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphomevalonate kinase</fullName>
            <ecNumber evidence="3">2.7.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_151410</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.2" evidence="3"/>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697516.1">
        <property type="nucleotide sequence ID" value="XM_010699214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLQ2"/>
    <dbReference type="GeneID" id="22573561"/>
    <dbReference type="KEGG" id="lpan:LPMP_151410"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150019700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_151410"/>
    <dbReference type="eggNOG" id="KOG4519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262935at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004631">
        <property type="term" value="F:phosphomevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016005">
        <property type="entry name" value="Erg8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035102">
        <property type="entry name" value="Phosphomevalonate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31814">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31814:SF2">
        <property type="entry name" value="PHOSPHOMEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017288">
        <property type="entry name" value="PMK_GHMP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="12">
        <location>
            <begin position="158"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIN96863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="458" mass="48723" checksum="2AE0EFC89455C17C" modified="2014-11-26" version="1">MEVSSPGKVLILGGYLIVESCTPSNVGISIGVNARFTTRIVKAQPAAADTSGQTTVHVSSPQFHQSFCFVASTLTPGTVAVKQTEGPGSSFIFYAVLYSVTAAQSLGSNTDGEVWMELLADNDFYSQRNYLESQGKDVSVANLRALPPHLPLVGAVSKTGLGSSSAMTTSIVACLCYHFNADGCSHEYIHRIAQIAHSITQGKIGSGFDVYTAVYGTCAYRRFPANRVSMMMDGAQQPTSVQVEALTRCVNMGEVWVPHESFRLPPGVKLILGDVHQGGSSTPGMVEKIMAWRNSVADTPDNLWEQLRHNNEAYIAALRRMIDDAAAKPDVYVAAMTALQQVPSLPLLETDNEPAQCIVEASRCAARSRALLRDIGIAAEVKVEPSELSGLLDDTAALPGVFAVGCPGAGGYDAVFALVLGDECAAAVEAFWERYGPLSVCPLMVREDPSGLLVKSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLX5</accession>
    <name>A0A088RLX5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_170190</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697710.1">
        <property type="nucleotide sequence ID" value="XM_010699408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLX5"/>
    <dbReference type="GeneID" id="22573762"/>
    <dbReference type="KEGG" id="lpan:LPMP_170190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170007300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_170190"/>
    <dbReference type="eggNOG" id="KOG0263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45333:SF1">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_625, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45333">
        <property type="entry name" value="MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="447"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="488"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="530"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="167"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN97057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="702" mass="75487" checksum="004F5BF25EBE8C7B" modified="2014-11-26" version="1">MGCLLSNTVVGRPTSPSIPSSPKANFHNSLLGGPGAMPGSRTGGSREPCGPLMTVNGPSPRSSPGGSVSMGKCDLTSSSEEGRRRGVENRTTPPLLRISPQSMKVTPTLNAADAPNPFTPMVAAKPSKTVSSSVSVPRSPCLQLTTSPAAGALPSAATRCLREAGHRLESSRTSSTVSASEAPHNMHLAQPPLPPHYPRGSLTGLADLHYTRESMLSDISDHLSTMSTLAHSADCNSSCGSPYEDRNGTINPFFRSDVGLEARRQQTPLGIEEDLFVYDDIIISKDEARTKHWRLAGRKPLLANMEPDNDSGASGAGKNFFSFNDFDVCVDEVDVMPMCTVSAEAVASLQQEALPETPNKRFKSMTVMITAAKQPNTVAHFLAQSRSKEPKANRPLRSFQASAHIGHATRVKCIALSPTEMDFASCSNEDASITLNNFGLGSEVGIFTGHQDTIINATFSPDGKYLATASKDKAMILWDVMTTKRLLTFAHPKVVICCCFSPDSKYLVSGCQDRVCRLWDTKRGREWLRYAEHKGIIIAIAFSPDGHYICSASADKSLRVWSATTAKTRFHLLGHGGMILSCSYTSDGRSIISNDELLLRVWSAEDGSCKLSVSPGDIAGSVRPSNRAPRVGWTLSSAAPGPFTRLMLVACSNRFVYILDMETGREVASVFCKAPVYCLAAGGYEKMACGDSFGNIYMLHLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLX7</accession>
    <name>A0A088RLX7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_160690</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN96943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697596.1">
        <property type="nucleotide sequence ID" value="XM_010699294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLX7"/>
    <dbReference type="GeneID" id="22573647"/>
    <dbReference type="KEGG" id="lpan:LPMP_160690"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160010900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_160690"/>
    <dbReference type="eggNOG" id="ENOG502SAFE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052410">
        <property type="entry name" value="DRC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24107:SF23">
        <property type="entry name" value="FLAGELLAR MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24107">
        <property type="entry name" value="YNEIN REGULATORY COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="65"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="470"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="488"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN96943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="529" mass="55259" checksum="926192188480EFAF" modified="2014-11-26" version="1">MESPSFSAAPISASDQDAVVAPAAAQVRTWLSLYGACCTEERVEMHPGVLSRVLQAVELAQSRGRLSSESDCTPAATATRHASRSGEDDAEAATAMPSPMPYCDADAGKGSTRVAGLSVDFGGLWMPLSEWIATLRSVVAAVPLHNFSLRDTALGDAGLRCLCREVATTSITPASVGTPSRCEGGIVRLPGLSPLPAPSFYPHPSPGLEATSALRWLDLSGAELTDGGPLALLLASCPQLHALNLSYNRLGTRDAGLALLCAALQLHPSLEVLSLRRNGISGSRGGPAIAALAELIVARSVEAPRSFSRANGPASAFCGQHAATTTAVVARSLRSLDLSDNLLGAYFLLSDTPMTHCAEEGRLAAALQYDVASLSGCHVGVHEGVAAFPLVTALCLNNTLVELNLRDNGLPDALLEYVEAKLRVNRRTTGGGASFLAAASTEAIASTTVRQVLFDQLRCTLNHIHAETTNGSGVMESTHAEPKDAQLTEGSPANSSSGPPVTERRWTTDEVVSLVQRLVRRVASDLSLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMU6</accession>
    <name>A0A088RMU6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase, putative</fullName>
            <ecNumber evidence="2">6.3.5.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_170970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.5.-" evidence="2"/>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697788.1">
        <property type="nucleotide sequence ID" value="XM_010699486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMU6"/>
    <dbReference type="GeneID" id="22573840"/>
    <dbReference type="KEGG" id="lpan:LPMP_170970"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170016000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_170970"/>
    <dbReference type="eggNOG" id="ENOG502QW0C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270858at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF67">
        <property type="entry name" value="AMIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="688" mass="75297" checksum="454E62177A6F32FA" modified="2014-11-26" version="1">MSSSISSATLNFSRDSARRMVRQLHNHVAEQRQAVMECRSRAEAMSASSITRDRRVDKAEQPSLLCFAKVASEKDVQQNFIPDMPLSGISVAVSDALDVQEFYPHAGLYTPMSSHAARAEFPLIPWLRCQGAQFVGKLSCCTPFGLSEGTVFGPEKPASVAVTENACDYVISCSLNGPPSVLCAVHHDMVGFKPTSQTFGTFTEQFELTIPSMTVGLSARRMDDLMYLWQLYTASIDPEEYLESSAKQTQSSTSPTLGSTGASSLPSAPTDRDASSPPVTTGELKDGHSVASAAGDASPFHAPSTTVTPHGGGPSHQQASDPAARLVQSISRWWSGQTAPEVKHPDDMPKCPRPEIPDHNPHNYTVRDRYGRIADIDVGWSDYNAVAAMADDFNQPSRPGFLRRLFTGSQEYERPQVELAVGYPAEWIDQYCRGKYTSSAEFHQRLTDAVRMHSALHYNQKLEIVPLAFDFSLEDVMEAVTIISHYQLARAFERVLAPATASAQGNEDAKSGEDNEQSGKNDDNSTVFSPEKEQQLSVVPDMESIKLSGHNAPATNWQNMFEGLPGVRGELPASLIDSIQAGQKLSIRDYHHALRVRDDVVRSTEEQFIDVDCFITPLLSDPYTSGDVRSVRPTLSFQLAGNPILSVQVDPQTPVALVGELGRDAALMEDAFCFLQFVRGASPLQSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RN05</accession>
    <name>A0A088RN05_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transmembrane amino acid transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_140330</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697267.1">
        <property type="nucleotide sequence ID" value="XM_010698965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RN05"/>
    <dbReference type="GeneID" id="22573300"/>
    <dbReference type="KEGG" id="lpan:LPMP_140330"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140008400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_140330"/>
    <dbReference type="eggNOG" id="KOG1304">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF458">
        <property type="entry name" value="SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="366"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="494"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="537"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="581"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="606"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="644"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="293"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="111"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN96614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="681" mass="73496" checksum="DDB7351FF13FC763" modified="2014-11-26" version="1">MHHNGSSDAAEEGNYHLSPASISSVVVSSPSIPLSPLPMTPTEPNTTVAAEQERQLLYSFLPPTPPLGHLARAVDETDGSSSATGASAARRYFHTPPLKEMGQDKVAKGFHRALPTTDRNREAPYYLSSDSSNEDGNHNVGRPRRDEGSSNSDLNHTPTARLTVEEEQAARLCAYNEMVAGSGAGDEGEGADGVVAANNRDFISDTVHTILPTAITRWFSLSANAVAQTSSSMVPNSVKSATSTVAHTIGTGAQHIGDAIDTLPDLMVKAIPPAVMSKDVKQLLFTDFSNTFRSFFHTNILTMPFVFRQAGLVGGIVLLSFVAVTSEYATEAYFGAKNQMKNAHRVVVYGDVPLMVWGDWYPMINLFYGITHLIGFIAFSSSNAVVLLGAMGMKGGGARALGLIIPSLIALPLVLMKNARSQQPLAIMSNILVLNSVILMCIDFTYKPQPPIKLWANSPSEFFVALGVTVYAFTGIGSTISVERVMAPERYHKLLRASVAISWALLMAFGLSGFLSYGNRTCSVMTVSIQSGPLRTAASALLFVASLAIIPQNAFPLCELSDRRVLGFTQLTQYWDLKPNLLRIAYLVLSSFAAFTVPYYGLILSISGSLGCGIVGLVVPAALDYVRRERWALREGRTLRFWEYFVIFGLGLYGCVVVVIGVVSGSYQLWKSIQTSSTDSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RN30</accession>
    <name>A0A088RN30_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">UDP-galactose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LPG5B</name>
        <name evidence="6" type="ORF">LPMP_180390</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697873.1">
        <property type="nucleotide sequence ID" value="XM_010699571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RN30"/>
    <dbReference type="GeneID" id="22573929"/>
    <dbReference type="KEGG" id="lpan:LPMP_180390"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180008900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_180390"/>
    <dbReference type="eggNOG" id="KOG2234">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="408493at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="512"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="535"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN97220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="559" mass="60238" checksum="2CA3B2F2BF0B64C9" modified="2014-11-26" version="1">MALICGISSMAMISLIVLVVQNSLLVVMTRFSRANVDAVHNYHTSTLVMNQEILKMIVCLVIYGLDDVYKTHQHDVASTDRISNTAHQVVGFEVCVPVTRGGRVRNVEHSASQSEGIEALSYLGKETSDAHISSAMLLEAMAVGDAAVESACHVAGDLGTSHNASRVVKMTSAYGRRTAFCGAAWFVSQVRRLLQSTSLAQPRHSSALAGTRACVSDKWRSSADALSALRSHGFCVLYRRLHALCSLYCSMLSTSVCKRDTLKLLLPSFLFTMQNFLIFIGLSNLDAVSFQVWSQTKLLSTAIFSVWLLDRKLSLMQWLSLVVLTAGVLVAQLGASAAGIGMRPTDAPHAPYSTKAPDLSGAKELHADKSNEPSSNALIGITACTLSGLSSSYAGVYFEKVVKTTSPTLSMRNIQLSLFGIPLAFASMMILGVFPNWYASAQCGQRVHWNIFSTPVMGISAIGGTKAHCPVRSFYFWQRYDEPLTWVLVSIHALGGLLVAVVVKYADNILKGFANGIAVIISGMMSSALEGYEPSLAFVLGSALVIGSSIAFHKFEPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNG5</accession>
    <name>A0A088RNG5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_150460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697422.1">
        <property type="nucleotide sequence ID" value="XM_010699120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNG5"/>
    <dbReference type="GeneID" id="22573462"/>
    <dbReference type="KEGG" id="lpan:LPMP_150460"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150009700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_150460"/>
    <dbReference type="eggNOG" id="ENOG502SJ0T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273059at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="316" mass="31953" checksum="9B45EA9D3A9D02E0" modified="2014-11-26" version="1">MNLYTSDGLLVSGGTDTGGLSVEQGQRLLSIYRLFLQLHHAGTGAMRIKDMLKPGMTDSVSEHGSAGGGGDKNADRRGGYGTVNPNWGSIAPSMPESPAYTGSIAVVSSGTPYPIFLLSSNALPQTHRLRGFASAAAPQQHQAATAATKNNNRSANGCEEIALRWGLLTKQNPSCSAATAGASAAVGAVTGAPANALTSTTASVDVTAATEMTAEIGPDSPVDKRGAAGAHHISMANTTSPCSATPAASAAAPPARTSALALSAYPSGWTAAELQVHTTKQVMVCTATELSLDLDEGVEDGNAPLLFCCSVQPTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNJ2</accession>
    <name>A0A088RNJ2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_200160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698215.1">
        <property type="nucleotide sequence ID" value="XM_010699913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNJ2"/>
    <dbReference type="GeneID" id="22574223"/>
    <dbReference type="KEGG" id="lpan:LPMP_200160"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200005400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_200160"/>
    <dbReference type="eggNOG" id="ENOG502SKWQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265920at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="387"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="621" mass="66277" checksum="0E0C32CFCB82717A" modified="2014-11-26" version="1">MSSVTIGERQKKRPSSSCSSFDSKPHYRTHPPRHLQHLEADKAPQFMPNSPTDSSPPTSPKCAVPRTHTMSPANSTMPSSKLPFSNSVTGTGAVLIGPLASFDSETQRGMLATAAECCSESCSSGLSRAAVLLSNHGVASPLVTPRQPPSILAAFCPLTSEAWQSGTMRDGIAVDANTMSTCSRTDSRTGLQSSLFFSPGWPQSSRLAAAQSALTSLMGTPGQFFTNTAAEGDETEATARKTAAFSASRSVSRMSSPVDFMPVYPMRPPEPFAMDFSSPLVPEVSFLTSPNVWAPRAETAKGFGATPAPSSCLPSEPLEQQSLLRSPLLYSLIPPSIPPSASLSSGFGCIGESKQTQNRLSRHRSAASAEPDDLFSRLGNKLRVRGAANASPLPAALPSVKSKRKKRDHLFTSPTRRSFRSPLINSNEASLSSFFVAQDAEAHRTIAVGKVSDEEDAAHRTTSANAHRSGLPEDVEGEEGVTATAAATATDDTFEDLWGILPAARRGGGATETPSHITTSSAPFETAPAFRCVTAFASETHETDDQLSEELNQPSHFSCAVIEKQRNVMVHQSSAGQQRNSVNTFTNPQRTVSKGLTPQQLQRRFSLPQDDAIEVKRRSCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNS3</accession>
    <name>A0A088RNS3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein phosphatase 2C-like protein</fullName>
            <ecNumber evidence="7">3.1.3.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_202230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7"/>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698424.1">
        <property type="nucleotide sequence ID" value="XM_010700122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNS3"/>
    <dbReference type="GeneID" id="22574432"/>
    <dbReference type="KEGG" id="lpan:LPMP_202230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200027700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_202230"/>
    <dbReference type="eggNOG" id="KOG0698">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000086">
        <property type="entry name" value="Protein phosphatase 2C-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="6">
        <location>
            <begin position="162"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN97717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="451" mass="48210" checksum="7A3C21039E6CD129" modified="2014-11-26" version="1">MPAEKKNDATATRKPDSPHSPKSPASSSATTAFATPKKKSIMRPKQKPTTVLVSKNNSTNSSTSLGKHQHFLSPLPTSSPTRPRDSAKGGLLPRVSPSSTGSADAPTPKPGCAGGDGKDHQVNHVAVPFSMSVEPSSRQNSATLNPICRHNSMRKTAFVVVDYGATAEQGTRKTMEDQHTMLFEGIPFFGVYDGHGGTQCAEYLRDQLHGLILGHPEVKTNPEKAIIDGIVEADRAFLARSEAETNESGSVCAVALIIDDKLVVGNVGDAEVVLSHNAKPVVLTVRHSISSNPSEEERIRSVGGKVCHNRVGHPNYNPAVVSLAVTRAIGDAGFKLPKYTDGKPSGVIAVPETSVTRLTDDDEFLVIGCDGLWDVMTYAEVVDFCYHRFEEGVPAQCIAEELAQAALMKGSTDNVTAMLVHLTRREGPLSTREFVPEAAVSTSTRNLSEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNU1</accession>
    <name>A0A088RNU1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyltransferase-like protein</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_202460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97742.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698449.1">
        <property type="nucleotide sequence ID" value="XM_010700147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNU1"/>
    <dbReference type="GeneID" id="22574455"/>
    <dbReference type="KEGG" id="lpan:LPMP_202460"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200029900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_202460"/>
    <dbReference type="eggNOG" id="KOG1541">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2877at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000700">
        <property type="entry name" value="Methyltransferase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039769">
        <property type="entry name" value="Bud23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022238">
        <property type="entry name" value="Bud23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734:SF0">
        <property type="entry name" value="18S RRNA (GUANINE-N(7))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12589">
        <property type="entry name" value="WBS_methylT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN97742.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="425" mass="46582" checksum="46B63E55339AE411" modified="2026-01-28" version="2">MPAPRPELENPPEVFYNATEARRYTLSTRVRRIQRDMTLRALELLNLPKDDATTATGVNCSALLLDIGSGSGLSGDVLTEQGHVWIGVDISCDMLRIAKEDELVYYDMGAAQKTVETEEAFLTSSSNARFDASHVKWGLIASEDDQEEVGLSEEKKGGDGEDDDGASGERSSSAAAGSGAAPGPHMVEVLQNDIGAGLPFRPGTFDGCISISVLQWLCHSTKKGEVPQRRLMALFQSLYNALRRGAKAIFQFYPSDPEQVHLITRAAMKCGFNGGVVVDFPHSARAKKYYLVLQAGQAQGGFVPPPALTAEVESVSDSDDGGSEGDSASSGEAFYDSGANGVENDDELYDSNSRKRVRVGGRDVQHSSKRARASSAHRQRHRRKDNRPATGTREWVLLKKEERRRRGYQTTTDSKYTMRQRKPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RP02</accession>
    <name>A0A088RP02_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_203270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698529.1">
        <property type="nucleotide sequence ID" value="XM_010700227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RP02"/>
    <dbReference type="GeneID" id="22574538"/>
    <dbReference type="KEGG" id="lpan:LPMP_203270"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200039100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_203270"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="68"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="102"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="135"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="286"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="302"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN97822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="341" mass="36812" checksum="DBB6432EC61DCFC7" modified="2014-11-26" version="1">MSLEDVILSNDVAGVRAFVNAAANNAVNAVNREGYVPLYFACMKLSVSLPVIEELVRLGAAVDGKGADGETPLYISVYNHRLDVVKYLIACKADVNAVNGPHRETALHVAARCGFADILSCLLSSGAGLNVRNARQETPLYAAAQAGRHDTVYLLLKSDANTSLSNEDGKTPLYIASEKEYKHVVVLFKASHDDLTLAKSLADSEWRLRPEPMMSSDQILDKAAADQQFAAAVRRRSSAGAPAPDTKPMEVVEIKVPEPKVRRHNPLTGESYGPCRTLEEVGYDSPPPIPTELQNRPPARLSRVGGTSMVVGTGTEEGGREPIRIDLIGGDVFKYYAPSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RP58</accession>
    <name>A0A088RP58_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_203880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698589.1">
        <property type="nucleotide sequence ID" value="XM_010700287.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22574599"/>
    <dbReference type="KEGG" id="lpan:LPMP_203880"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200044900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_203880"/>
    <dbReference type="eggNOG" id="ENOG502QUYS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="68437at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057466">
        <property type="entry name" value="CFAP46_TPR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25439">
        <property type="entry name" value="TPR_CFAP46_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="969"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2047"/>
            <end position="2069"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1995"/>
            <end position="2025"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2600" mass="284118" checksum="949FA55CA31FA8E7" modified="2014-11-26" version="1">MMLGNTSRVKQLLSTAQIYRRPGLLHEVVSKVRDAELSSGRPSAELRVLCAEVAVELKQWSIAAEALKGVGTAQETRLLAVRFTFCEVLVALHHIDESTFMTHEEKVQAYVSGAASALQALAEAVELWPDSLDAVLRGIHTLWHIASFLFSVGREADVCEAVSFLATLHQQLHIGGGYTLVQWLVRAALCLRAAERYNEAATRFSAALESAALMGNQRLFVQVLRLAAGVIFVKEKGNASCKTRFELLPGYRNRPVHFAVLLTYLLLGGLVEVEACKEDLQSAYCGLSEFIDAAPQPPESGAPASRGKKKQAAVKAAPAARLADAFAVTDPDVIDEVKSDMLFCISLHGTLSPEQVEELERKRSSLNCRVRSFATYAHVVRESHRHGLSSLGKCADASSISTSHRAEVRALASELVNVLKNTNAIHDESERQHTLRIGASLLWNLMLPFFQSGTMGDVQAALAAVADVSQAFVPSLKKLFFQAVTLQCQTAFEDNNRSVLHHLLPMLQRECDYGQVEGEVPACLFRLHWLQRQMAIRDELENSLTSPQDRCLFALEQARCISNPLKRIPVIKTAFRHLPPVVQESDVLPTSAEATEPQKAAPVRGVFTTCRSTVQVYRELLELCMQDLSASLYAVAMAVAEALRGLPYPVSAAGNTEIEEVRAAASLHAATILARQLEEGEPHRSQKDARSAELAEPRIAATEDSEGCLAALLLEAAQRGAELECRRSGSGSWIAANACVAFLNWKRPAYARGEYRAHLLELLDLQKLYIALFEHEQVQDVELLSALTTSSVIGLVVEYLEATKPPPELEGLPLAKQISRDGFEALVQRLRACTHCEPSNAQLRHAQVMCLEALHLIPVMKQKWFLATLSPDLARLLGDKPTFALHPQEHLLILLGILAGPSEISEKTTLLINDARPLLRKDPCVRLCAWVAAMAMQLRQEDVVLECCEVADRLYACNQLGWGSMFEAQQPSPPSGAASAVVSKATDSSSHKKAPGEPVPVQLDVPPTFPKPDAEDWEAYAELLSLKAQIGAEHLNGLNGNARNRAVQLLLTNCVNSAIAAAQGPPASKVERITNAYGLYYTFLRTTRISLETATFVLPSLRMLLSKALLAQLPKRSWSDSFTTVVYQLSCVLVYVSFSSEQEDDANQLVALLHPLRELLPPRYQKSLKDREVAEMCYRTSSVDDFLQRSKNVEAELQARGWMMLSEASANASGEAETFALALAASKGNPLVTAQCLFEHAYATTLRRGDSTPLAQVTRHLQEALRALEGLPEAVPLLQSGEETQRWNATLAAASHTATFLHSQTQRRLALDSDLAGEAVVAPDAERRAAVLKASMKSRATRTTGATFHHAFLGLRIVSLLFRTMGTHDVFDIGTASAQRAQHTTVPASRRDCVNVMLDYVSCLWHLSAKWLCEDTADEDAVILKLPAANSLYYGYAELSAAAQRLRGCVPDEEFKLNTEGLWQCLLDLGDYLARTGDEPHAFMVYSWVRFAAALTFGDARGDSRCALVQRLCNWKMCAAAASSGLSDSPYVAALTLLADTRFLVEEAVKRDVEGKRVSPSWEAAMVVGECEIRVHLGQTEEAATLAEDVLCRGLECASWNAPVTRARALRVRARYAAICLRYGDALRTLQQAFELIGVSTLSTAPTVISVRLWTELCSDQLTLLIDAQSTAEAVQWAGTVRQQLHQWRAASAAGATQADTPHAACVRAEVEDVLEFWVSHIITIVEQQPPLADVIGYQVAYSSQAQRRIPTEELLREVLLVAEGSTTLHSRLYTTHAQWHLRDRVTPQWLTQHSANVNDVRARLLVLLAEMQVLDELSLHLQNMPTSRDVEVDSARQAEVGDVLVTGMSFWRGTLFYWTAIDRLEASELVSCLLVAFQHLSMEELGLPTSNAPAHCEREVLRFIRGAASSPSLAATADGVPKTVVQAVKVGARWSSDVAHEVGVLQQALQYYNVTDPSAQAMLEVSAVPALLEKAAIHCRQWPHTRLAAAILVAVAQVEMLQRVENQLEQLDNLLIEEQQARAQALLTAAWSRARLLPARIDKPGIRTHKSTGAGKKCSLNEPNPTAMASPLTEEEEALVQRISLGIQVAVHHGHFDMAAQLSDKLGHLAVLLDHPRLAAAAAECTQANQLVGLLWRRCVHEMRDSAEGRLWRQMQAVQPLVTNCTSYTQLAHQVMAATPMERALRSCSLLCVEPEKKLAEVSSTPPAKGSHITEVSPYAMDSAVLSVAVGNCWTGFYIVTLRHPSGAVEGRRRYVPQQTWAALTDALQRTEARKQEQLGSTDDMRVSSAEERVTAEDLSNVLKELNAVAGELFGEFQASLQQYCEKTPLYLCLAPELQSFPWEQTCVLSCCPVVLRELGAAVVVSRIREFQRYGKRALQHTQKPGGSSSTKGASSGSLMCLIDVFGDHPESVAATCGTDHTKSKVSPQCLVTCSSAGVPPDAEYLTWMLQNAAPGALVVNMCGNLTDALPWSDLASLNFTQLNGAVLADGASNASSQQREERLRISALVTGIGKAVSPSPYPRWMTAALFLLRGAKFAAANAFACSPSVTDALARRCLSSVSSGKALVEQLRGKSGDVKTPFVKLYGILGSGSFKSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPG2</accession>
    <name>A0A088RPG2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="6">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_201760</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="6"/>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698377.1">
        <property type="nucleotide sequence ID" value="XM_010700075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPG2"/>
    <dbReference type="GeneID" id="22574385"/>
    <dbReference type="KEGG" id="lpan:LPMP_201760"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200023000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201760"/>
    <dbReference type="eggNOG" id="KOG0581">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06623">
        <property type="entry name" value="PKc_MAPKK_plant_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF9">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="58"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN97670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="385" mass="42920" checksum="E9B866A739E2645E" modified="2014-11-26" version="1">MPPKLKPLPAKKLAPSAEQPEDSDELIVGNIRVGPCGVEFTGEGDLQVRRPDLNFDNLRRVRQLGKGTQGNVAMYVTADKCVFAVKKITIPRTLDSRTRQTVAAELRNIFTAQSNEYTVNLYNAFYRNRALRLVMEYMNWGNIDELIAETEKIPVTVCGYIASQMLHALAVLHTKSNIVTEPNQHKSLCQIHRDIKPANVLLSTTGCVKLADFGIATSAETIGVNSFVGTATYMSPERIQGRRYSTPSDIWSVGVVVAQMLLGHYPFYSVSKGFMALLCEINSVEKYPLMAATGCTQEVQDFIDSCLRQNPEHRSSAFELLESPWIKHCEEHGKAEMVALLNLLGDRNRQYHEEDSCQAASREASCLTIPRDTSEECSTDNPLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPP0</accession>
    <name>A0A088RPP0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_204390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698640.1">
        <property type="nucleotide sequence ID" value="XM_010700338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPP0"/>
    <dbReference type="GeneID" id="22574650"/>
    <dbReference type="KEGG" id="lpan:LPMP_204390"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200050700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_204390"/>
    <dbReference type="eggNOG" id="ENOG502SKSM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277199at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39666:SF1">
        <property type="entry name" value="NUCLEAR PORE COMPLEX NUP2_50_61 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39666">
        <property type="entry name" value="RANBP2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="860" mass="93916" checksum="12F4FBDFFD237FC3" modified="2014-11-26" version="1">MSAFSSSTTEYRQAIMRLYEKYDPTNVSRVDALLHRFLGREEALMKALERKFSERMMSEGEQTSTRLTGDCADAAQCELEACFSGPPPHVAPTAIISRKCDDAMLSMAAVQPISASSDLHAATVSEDVDCDNYRMQFIRLCETHSPLRVSPVDHELAKCKEQEEAYLHALEKKLIEVQPAEAAKDSVEEASLPATLPTVEVRLRDDHPKRTSDSAGYEMNTARLLRIDEAYAPDQAHHVECQLQRYAGREEEAIQAVVAKYGPEPVPLVAETELINPTVTIKSEETSTATENNADSLQIPFPSGPLTIAATPQRAKKTTEHAVDGVAASAEAEATLSAQAEAAATSTTTQKAKAVSVTVRATEHEGNGVDGEAAPTQVPKLDAAVSASAVPPSSGGTQRASSPPAKSVVATGMTSNSLVLSAVAGSLRTASARKGKTSIRTSRLTKDVFPACKGEVARDLILDGNEVDASLRRAVRWTAPFNIAFYDFFRVLGSYHAHGGERVSLRVANTLLSALFPEMSPRKVLWEYGDMACTGEDGVGVSAEEMRERIVQGAARQLRNSASVSNLHVAQYTWLLVRRMESFVKTCRTAVLQLQRQPRSLFAGFWVHRAVLPRAVPQWKRCWATMGADGDAVLVCCVGSLKTEWHIPFARVARCYRENNATGAPRAYMRNGLAFQLITGVPPLIVVVCPESSDVTLQLLSTFRSWSSSPRDIHGRCSATHFASSPVPAPHSQHDGAESRKYREANQVRVWVLVRAMSTYELQRWCVEGVSIHMVSDRTRKVHTCAVVDVEGAFAEMKLPVTPPARSAYGFVLCFHNGVTPLMAFTEQSQARTQLLDRLYRGQVLAQVEAKTMCRRGGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPZ6</accession>
    <name>A0A088RPZ6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DnaJ protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_210520</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698839.1">
        <property type="nucleotide sequence ID" value="XM_010700537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPZ6"/>
    <dbReference type="GeneID" id="22574874"/>
    <dbReference type="KEGG" id="lpan:LPMP_210520"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210009700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_210520"/>
    <dbReference type="eggNOG" id="KOG0712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000033">
        <property type="entry name" value="DnaJ family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000074">
        <property type="entry name" value="Heat shock protein DNAJ, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="8">
        <location>
            <begin position="125"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="5">
        <location>
            <begin position="125"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="377"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="384"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="411"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="446"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN98132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="458" mass="50384" checksum="76C58AA549607B7B" modified="2014-11-26" version="1">MVRETELYEVLNVSVDADEHEIKRSYRRLALKYHPDKNTGDEAAADMFKKVSNAYEVLSDAEKRQVYDKYGKEGLEKGMGEGGGFHDATDIFSMFFGGGARERGEPKPKDIVHELEVTLDDLYNGATKKVMISRNRFCGTCKGSGLKPGGKRTTCFQCRGRGVLLRTQQVFPGFHHQVQMHCTACGGEGEIVAATDICTGCRGKRAAREKSVLEVHIDRGTSKSDHFTFTGEGNQEPGIRLSGDVLIFLSVRSHPVFHRINDHLMIRCPITLQEALCGLDVPIEHLDGRELIIKASPGQVVHGDSAWSVYNEGMPVKGTGGLQKGKLFVYFDVQWPETLPRVQIDKIVAALNVPEKPNKLGGQVVELSEYKAAGKFKGGKKGMRAGVAGAGSRSAGAGRGREAARGRQAYAEEDEFEDVTDDDDDDDREHQQHSGQQYFRAGPRGFSSNTQTVECAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQ14</accession>
    <name>A0A088RQ14_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_181590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697992.1">
        <property type="nucleotide sequence ID" value="XM_010699690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQ14"/>
    <dbReference type="GeneID" id="22574049"/>
    <dbReference type="KEGG" id="lpan:LPMP_181590"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180019300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_181590"/>
    <dbReference type="eggNOG" id="ENOG502RYPB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276346at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="256" mass="28901" checksum="E9FD5F7D63697D6C" modified="2014-11-26" version="1">MTVTMDPDAPSVLTSEVYNAAEAIFNTLQNKEKLVSFLDCTTLLRGMGMNPTLEDMDKLKSLMAQPILRLEQWRREEELKREKERRKEEARERKGRGRASVAPGRKSIVQKIADPVAEAAPADNTVAEEIKNIDWNIFIRCTEMIFRDRMREECAVLEALRVFGGDSSTSMSRSKLIEIVTTKGDNILTPAEVKILVTLLPESCPVNEWAGRIQGTYVAPTQEEIDAAAMREIEARRHQEAAEKQKEAEKDPLKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQC0</accession>
    <name>A0A088RQC0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_205690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN98060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698767.1">
        <property type="nucleotide sequence ID" value="XM_010700465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQC0"/>
    <dbReference type="GeneID" id="22574781"/>
    <dbReference type="KEGG" id="lpan:LPMP_205690"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200064100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_205690"/>
    <dbReference type="eggNOG" id="ENOG502S1W2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273120at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="719"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="806"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="733"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="815"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="853"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="933"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="959"/>
            <end position="975"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="975" mass="103786" checksum="8BEC2FC200092EE9" modified="2014-11-26" version="1">MYSFLSSSASRTEPLDWVALLTNALAVAREAPSEQVLNTLTMMQSYASASQDVFTNISRGVRDVKEYVALLCAMDETIGTWPLRVRQLLDVPPVVLVPAGGLGGSLVTAAVHTPRGEALVFLFNVSLYHMDAGLRYLARVRADASVMISSNASRRLGGGGSVAAPNQNAKLAAQHFRLAVDVLHWAEALHANPSSPSALALRQLRSHVPLDMTRDMGMLCSAVAKYMYALSSASTKDKPDVLAKLAFDAAQLQLPGGVSTNSSLHLLPSLLLATYHYHKATWYYSASRVPSMSEALGHMQYADTLLRSCNAQWGMEEAHMQAEHESRQWWGRRLATFFTGARRANASAVGRPRNNLPGDSSRTSRVAGAATSDEADDSDDAVAAALQPATEYPRLHELLLRGEGRSTSKVKKSLADDGNDSAPAEATAADVVQVYPYLRLLLQDVCYYLQRYQRENELVYFAKATGADAVRRDVPDVAIAIGGGDAVEEGTLFESRASLFASLPSAGTLQLALAQEEESGQAQQALARLLQRVERDQRQLSIFIAPPNSLLQALDAVETILPPAAQWGALDAVVNTAAEAVEAAAQDFIDAASAWQEDHDAYVGSRCAAHSLHEDTRTELAVWSERAAVALQRWKALGLPAEVDSRSSLLDALVPISSELHAYLAQSEYVCRDARDVLMCSAGSVTLAQVQACTASMDAVKQLGTELLTSVAAAAPRRSTQRAPRCGAGGGTRTLSSDSNNAPVGVEDECVPAPQYAEAEAAIEAVVQVLEEAPIVVAHVESAAAELRDMQKKTVVAPLDQFRDVRLPPSPIRRPIKEEAGGEREGGGAVRTRAKGAGSVIKAADPTDRVPNATSRDSAAASSRKRTHTPSPERQPLLPKPADDDTSDSVSSSQLADAKEVAVGEGEGATRATVSGSLLSRLKANKARCPQGSRSTSATASSPSTPLRTAPSVTAAASAKRKPTAKASPSKRTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQH4</accession>
    <name>A0A088RQH4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_211190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698905.1">
        <property type="nucleotide sequence ID" value="XM_010700603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQH4"/>
    <dbReference type="GeneID" id="22574941"/>
    <dbReference type="KEGG" id="lpan:LPMP_211190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210016100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_211190"/>
    <dbReference type="eggNOG" id="ENOG502S35U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276198at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="142" mass="16502" checksum="C3EEC54E0491E869" modified="2014-11-26" version="1">MVRYVQRPWFSPLGFMASSPTAYAPMIACIALAAIFPFRYHISEYFERQSDGSHVELRRRAVKYYAEMERMHRRQALVNLESIQDDNAPHRLSAVLSVESIQAGSLDQEYNYWYAHERDAIRAEKLIMEIRELKAKMAAEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQI9</accession>
    <name>A0A088RQI9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chaperone, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_200120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the p23/wos2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698211.1">
        <property type="nucleotide sequence ID" value="XM_010699909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQI9"/>
    <dbReference type="GeneID" id="22574219"/>
    <dbReference type="KEGG" id="lpan:LPMP_200120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200005800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_200120"/>
    <dbReference type="eggNOG" id="KOG3158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1564555at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06465">
        <property type="entry name" value="p23_hB-ind1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000039">
        <property type="entry name" value="CS domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045250">
        <property type="entry name" value="p23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932:SF1">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DAF-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN P23 HSP90 CO-CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="6"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="154"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN97504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="207" mass="22774" checksum="5DDC07A483F829C7" modified="2014-11-26" version="1">MSASGPLVPPISWAQRPEYVLVTIPLQDTTGVTVEIKDEGRELLFACCAPEGKQYACTIHFYGAISSEESQHVVRPRQIELKLRKKLTRSLEDADDEVEWPRLTKEKVKYPNITIDWSKWKDEDDEGATDDLGDFGLGGGDAMDGQYSEMLSQLMQTQGKKDAEELAGLPPGTIPEFGSAQRQEATHGASAAAGDDDSEMPPLEDDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQZ8</accession>
    <name>A0A088RQZ8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_220050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699007.1">
        <property type="nucleotide sequence ID" value="XM_010700705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQZ8"/>
    <dbReference type="GeneID" id="22575051"/>
    <dbReference type="KEGG" id="lpan:LPMP_220050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220005600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_220050"/>
    <dbReference type="eggNOG" id="ENOG502S04R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272721at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="443"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="51"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="230"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="443"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="470" mass="54626" checksum="F34CC664CF5F5436" modified="2014-11-26" version="1">MGPPVLTSTAASEEEGGGPTALVPSMEERWSTFQRLTRASEAAFRGMSEAAARQNADIAAHQQEIAAYQESQRALFTQQQQRLDGLTRECTQLRQSEAGMKEVVAHQVERLVVLESELQAMRVQLSEARLLHAQCVEERNRLQQACKMHEVHTGELQAALRFAEEVVRSMRHTVGACEQEKNEALMHQYSHFESYRNDLVAAYDQRAMEARDEFTKRVESLHVGMLETVAKREEQLRATWEEAAARLRHEYDELVRLGQQRRAAMDTELRERKEQLERDKELMRAQQREEAGTMEQRFRAREETLLDDISRRERELREREAALRAAQVQQEADVQRRLQSRESELRAAHDAALKRMADQAAAEREKLSENFMERLQQLSNAHMQQERELERMHREKEREMAQRYRLSALDGGDRGEVYDRRATEYGVVGPNMAKEALLKKFESVEQRQRERSDKLRSAFSVQESEPRPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RR39</accession>
    <name>A0A088RR39_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_201450</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NUP186/NUP192/NUP205 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698346.1">
        <property type="nucleotide sequence ID" value="XM_010700044.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22574354"/>
    <dbReference type="KEGG" id="lpan:LPMP_201450"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200019700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201450"/>
    <dbReference type="eggNOG" id="ENOG502QTEX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272187at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021827">
        <property type="entry name" value="Nup186/Nup192/Nup205"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1720"/>
            <end position="1783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2507"/>
            <end position="2603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1721"/>
            <end position="1735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1748"/>
            <end position="1758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2507"/>
            <end position="2519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2587"/>
            <end position="2597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN97639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2695" mass="287071" checksum="66F1880BCFC96181" modified="2014-11-26" version="1">MFRASTNAPQPSQTRAAPSCGFPAAPTATLTTASGSSGAPVTAAQPPQTVNVSSGAPQGQHAVTSSPPPAPGGFACRNPPVATGGLGNASAAPAPASAMQPATPPYVELFAKACRDGVVSDAFTQELKKRFSTPMEVTVAPPATVPQAITKALHTGAQWQAAVAPQATLTNFSTSTAPAAVASVTYSTLARANEPKQQQERRRLQVEQALEFLQTLLLCDSGYNNSEAPPVDNPATSPWTESVGEVKGLHAAMAAVAVPAASNLISFLKTTITANSQASDGEAAACTLFIDNRRKRPDKSPVLLAAQCLYVLSRHFQLTVSVVKEALDLMETLYLLLKNSLQNRIVPLPAFSDNVDTCCLNTLLWLCVFSVVNMTAVWKKLRSTTGELHLNELIHSTAAASLGTAVSALRCKLRESVQAPSASAGGGLYSDVLTDARRGGGGELLLGGGSGGDRAASSLSPAVYTWQVLADSYLSILTLAEGCLLRAKGSEQGYDKALDAFLGARMASPSSSRMPMTPASVAVHRGKVTKRMVQLAPVPRTLSIPLGLLYIAPYEMMSYLFDEMLPLLRHLSELEVATHRRYCEQLEELPRLPASMRSGGVAAPEAYYGYQHRGAAQNGRTEETEDAEVLLQKVTRTGAGGDVIGEPFTSEMAHLLEALAICLQHLPPKVLNPDLDSDCAATFFIFKNFVKHMRQVFATQRSSAPSATVGATGGGSCSISGFGAKWENYTLKLMTRFLEVMAMIGRNPQYTQRVVVLLTDAQTECGEMQWHSLVSQALECAGFNSAVIGTPGALGSGGSADSVMALAAAAAAQKSSAGSVAGDAADGDDMYTLLSTVPGANRVPRALHQQFTRAYARKYQRKFIASFFLLLRQLFGHPTLQPIVSAHMTLALALTFLSAPQQSQIMLGSTLSLISALITNAADAQLVWSFLEQRRLLHQSSVRTQHQVHEGGTSASSALDNRFTTLSFPAAAGQRESPVHEEALSIIGHCQCECTQGTYDITIGFLNLVTALFQHDQPPMAALPVYNTVTHFISHEVLRGVLKRMFSHSHERYTVMALACAVLRQALLVRFRCDENGRTAVLPFPVIMAINKAPTDVVGEVLKLILEASDASYELLSHHRAAVRQAMRLLITAIQTVREQSIELLLFDNRTTLNNDLAVRVLGMCSLHDTLLTKTTLQLLLLFPFETANQAAHYWAGLTHKYAPVLDSFTQLLHPLNTAPMVMQAPPELAQLDFQPSELIPGWSAAVLIETKSLLLDLLMQHADVTEPSLTAWMGGFYGEDYSRRHRRGQPYVSAAARVASIHDNATDGNGTAGEPRWWRSTLLTSVVEGACSCEVERAHPALAVKYVKLLYLLRANRLYGSLVIRPFLESVCQTLFLRLQHYQASQCTPVALSKYAYVLKLLALEVCYTYRTAPENLRLAQNTTITSIAVEVLLSLLYPFGSSSGPAALSECEYGAIADSGVRSLYEVDGFDSETHANALSQRDVDQDGEQQWNAGVAVMSRDAAVDITSWLPQALQVLPTFPEKLPDVAGGLNHLVPAATDGVVQYNMTSLYSAIQAEHARANKPPMTMAELRERLRPFIAANDCFFSYAAGVSFVEGWCQLVSVSCSVVKGLSVSRLSSFALCILRGLDATTRLTAAAQEQVAVRLCHCLSTVMAHLRQTVCASVALSLTTPQNAEAEAAWYEQGNGGYPGLQGGGGAPLDTARAVSYRHSGCERRTASSVSAQPITATTVRSHGCGVEREMRIGQRRPREKSRHTTPQYRNSHGGGGATGSASDKTGKSFATNAGELSNFFSVANRSQLAQALIQHREAERSGAAPISVAGEETTTLASWSRPEVTSASLLLGPLVRALVHWGTRIASTRAELYLSLLCLAETPGVNLDDVVVWRFQRALLDVVCTDICGSSGSSASGGGENRLGGNVAAEQASNGLSGAAPANSSGSGATALSAHPQQAVALLVALLQVSAPIRDEFCHPDPGGGDELGRWALRCATALLQSVDRAVCNFLTSNGAQLGTLLWHLRSAFDVFSVISLSHSSQVLHSDLLHSCLSMRAWQYSTLVVLGYSQATPSFDQVPSRTLVEQNKEVLRYLLLGVVRWVNLLLSSLGDAAPLLYEVQKFIRDNRQLIDHIFISPTAVSSTIAGSARLSASHLTLCAEFSDCLRALSCSVLAVDCRSLVDGMALTELLSMLSSEELWHRGPTELHGFADVDGEEGSKSGAAGGTSVVASPAAAGAADAECGDASDGEDAGGALVKLTRATSTATAHTFSAAERGRDVVALTVRNLAHLLLNTEYGHRSNEDAGVFIACADSPPMLRHSAAKRQLVAKIIRHVAHSLVQSSTSEVREFRLECYLYALHAMVCLLHSFVLPLACSASSQTQSSYTLTLPGDFVRYLSELPLGEFTNTLKQAQEAVYQLREFNTDYRGGLRASRVAANAWVIGTSSAGPHTLSNSVRVASAADQKSTVSSTPHNLPLSPPAAAHVEGGNTDAFSTPLAPGLLPAVDALGGGRNTATGSQTISKASTAVEFAQASSGRREPYSGDPPPSATTCCGGRPGCDSNTTVAFDLDGPSSRPPHVQGRNGASTPPGVASTASDSQSSLLPATDDGAKLSPEVTLWELLPGRGGAREGEWTRLYDAATALDVPGTAVDGDLDSTGIRSAPLQWKDVLNVENEVRQVKIAIANALRATKGAMYLVRKHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RR44</accession>
    <name>A0A088RR44_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane protein 234</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_231320</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM234 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699289.1">
        <property type="nucleotide sequence ID" value="XM_010700987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RR44"/>
    <dbReference type="GeneID" id="22575337"/>
    <dbReference type="KEGG" id="lpan:LPMP_231320"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230020800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_231320"/>
    <dbReference type="eggNOG" id="ENOG502S4KS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="43458at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018908">
        <property type="entry name" value="TMEM234"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28668">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28668:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10639">
        <property type="entry name" value="TMEM234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839032" description="Transmembrane protein 234" evidence="7">
        <location>
            <begin position="18"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN98582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="121" mass="13074" checksum="5034778F1BC31DEF" modified="2014-11-26" version="1">MILLMLLAALLWGVTNPLLKHYSRGMPSRGSAKDDTLFLLRRPKYLVTQAVNLSGSVVFFYSLREVDVSVGSIVVNSLAFVITVLMSVFVLREGLLCPRTATGCLLVMVGTALCTYSSGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RR59</accession>
    <name>A0A088RR59_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vacuolar transport protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_220870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NPR2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699087.1">
        <property type="nucleotide sequence ID" value="XM_010700785.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22575133"/>
    <dbReference type="KEGG" id="lpan:LPMP_220870"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220012000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_220870"/>
    <dbReference type="eggNOG" id="ENOG502S6KK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267732at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009348">
        <property type="entry name" value="NPR2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991:SF10">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991">
        <property type="entry name" value="NITROGEN PERMEASE REGULATOR 2/TUMOR SUPPRESSOR CANDIDATE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="345"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="610"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="916"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="970"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1092"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1346"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1410"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1525"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1611"/>
            <end position="1640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1736"/>
            <end position="1759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="345"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="651"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1092"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1360"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1418"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1624"/>
            <end position="1640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1833" mass="188203" checksum="6EA37B5DBFB78DD1" modified="2014-11-26" version="1">MQHSHATSMARNTTTTATTALTHSASTASSDTLFRLECVLLFALDVVRGPYIHSSAPANPPEAIRSFLHSQAAPDSSSPAAAAYSAVAASSLAAGSSTVRCGAPPLQQQQPPCLRKVSPETIGSDIATAFPAGSPTDAPTALPNTKWASSAILASRSFGASSIGTSDCVLATGSFSSLYVPTPPSPPQLAAAVDAPPSSEPSTLQHSARVPLLSQPPLPAKSLVNHADATSGLPISILGNMPSSSMRSVASSNMAPRCLVGLSDPPTSDVARAYVVGASGTERAASEDIAVFGVSPQTCKSDSHRTLPSLSATMGLCAFGASRSAGGGDGLALCANSVEHVGESAHASDGHCRDTRSEAPRALGGKTGIGSGTPLTGKPAAARSAPLPPTNATVSGTAADSDRMSGYNDVFVPRSEFCRRVLWLYPAESGLLFLYYPEDIPGEHYQRKTLRYSLCLVFRVDHKRMTIGDGLLHQRVHPYSVVLTNIAEELREAELKYAYMSRGLRSFNSASRQLSSLALISPISSLPAPATAAFHAAAPPPVTSSITTTPATEGSEDVEEDVGQAHVATALALPSGAAPKPYALPCSRTTGQSGTVATAVSAAAAVGGTVRRQPPAMADRTPALRMPPQQSATPSLGEGTEGRRSAEGVTPTASGGCNWQQCKGGAGDAQGCHNGEDGSLPPGVRGSAASSPRVITNTAASTMANAPSPGLGTPLSTPMGTHSCSSGGLTGAIAVDTASAGADGVAGDGGVRASSSYVISMEMINMATAPPSLLPVCSRTMGEAAAAADHPSPAQLEALGGWVGTPVSHSAAFSSPSATTAPASAFSADLGGTRQQMLPLHSTVGANPITSPRLPFPHHGLTPTAAVAGADDSTTAVPNMHILNAFITPPTAPQWTPLNELVAEIFHCLSYTSEAPDGTGNCEQDGPIGSPAAGGRTPLTVSPTSAGATIGLAAQEPKGALGAEISNKAWTQRPNPTTSASPTGQQQQRGDTSVVHLSSRLSFHVRRMAPLQSARLLHLDHVPVPVVAYDPAMMEWMDMAVHNVFRLVDGVRTVADLVFSVAMGTTTTLAEVCAEALQRSAMERQAAQMMAPTTSLPGSSACTAQRSATTSGDRVRSAAGSPNQPIVVSVPIDTRLCPSLLPGVRYSIQTSAAAVTISDGQVPLPSHVNVRVTPGAASGPGTLGASASVSSGTSDSAAAAPIASEEPGSNSVATTAAASSSQSLHIAVELPQTWVATTGIVMEALLHLELCHLIKVYLPWTEETLYSITNSAQRALCSACHPVRHVLAHYLLCVAWAERQERRKEQHRVIVERNPVQKESIIEQREARLASTSLRIIPPALPEKQHASAPLGVVPPQQRSSATGAVASPPVPPSSTARATAPEVTSVSGVGSAVTAIAVRSPDRLIDSSAWSPAASPRMSSSVPCASGTSHIGLHQQRPHQPRSLAPAGYVGSPSVVNAPRADTVSINVGGGGATHTRGLDQYSADTYASSPVSTSFAPSSLRHELSVGASGRLQLTLMNSLSTFSPRRSDFGGGAARSGTSPRLFLGNQGNQTSSGLLPCSATGVSQQQRQQQRWKQYPHKQACLGAAASFHSCSSTSKDSCASGSCRSSSSASPSVCNDGDSSSVPSSSSSSSSCATSMPMSVSNMQQLVALSVAGVSTAPTSAVLEGIEVPVLSSLTASAAESSVLAQASKDAIIVDTVVDPVQHPLDPPSDYGAGIELPTAELTAASALRTAERHAKRTSTAEALQRENRRHHSPSVKVFAPTEADVSHAAAAALCALAKFNNASVLSVQKEMRRMPVWATSFNYWSDRCVKALVEVALLNNWLEDVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRA2</accession>
    <name>A0A088RRA2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_221350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699137.1">
        <property type="nucleotide sequence ID" value="XM_010700835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRA2"/>
    <dbReference type="GeneID" id="22575181"/>
    <dbReference type="KEGG" id="lpan:LPMP_221350"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220017200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_221350"/>
    <dbReference type="eggNOG" id="ENOG502RT7Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275798at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="445" mass="49871" checksum="AF39CA8E61106E69" modified="2014-11-26" version="1">MLRRRNVTLSYQRGGWTPGSKHQKHMSLNPTMYLYRFAGPHGPGPYVMKYWWTLGCLPTGLERPFRLSEFLAEYQQQHVPIEVEEWLKCFVRNPYEELADATSELLKYLEEVPRRENTRGYRSIESGVSSFAAPLAKFERQLNVRVPSLALRAALGSASLRERLKDDLFEYRESLRLCGSTPHRRLARFAFDELLTLPRSSGVSEKIDNLEGQISETIREAVGSYVSPKSSTSDDEKKLIRLLTTFSEGCVLKEDYDSALSLLSSLLNFSHDDDIDAVVHSNASTAAILGGHYKEAEFHGRQAALLEPQPVSSRKSCGRGYVLWATAAAYQEEFDRAGRIVEKGLELFADNADLRAVREKLASTKLAASSASPLSTSIVRSKGQQARGLLHGSGRSFDNEFDWAIFKNKLYPSKMNPSSNEMGSVFRRVGDFGGHISTSRSAEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRP0</accession>
    <name>A0A088RRP0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_231150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699272.1">
        <property type="nucleotide sequence ID" value="XM_010700970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRP0"/>
    <dbReference type="GeneID" id="22575320"/>
    <dbReference type="KEGG" id="lpan:LPMP_231150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_231150"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="100" mass="11097" checksum="9D249E6A302B37FE" modified="2014-11-26" version="1">MGSSCGKTQTAAKEEAHGEQENFQKEGEQVVNNGNVEVESQCQQPEKDAGEKCVEEDKVQKEEDKFEKDSQDKSDDMKKQADANGDELEKKALEEEAEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRT9</accession>
    <name>A0A088RRT9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_231670</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699322.1">
        <property type="nucleotide sequence ID" value="XM_010701020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRT9"/>
    <dbReference type="GeneID" id="22575372"/>
    <dbReference type="KEGG" id="lpan:LPMP_231670"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230024700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_231670"/>
    <dbReference type="eggNOG" id="KOG0800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045191">
        <property type="entry name" value="MBR1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22937:SF65">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ARK2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22937">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="325"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN98615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="402" mass="43259" checksum="328F91001EE2E7EA" modified="2014-11-26" version="1">MPKRGRGNSADASYAAAHSVAEISDADSSSTQPISVEEMMESHQDLVLEQQLDALEVDEDFRESLRAMTPNTRRDVLNDIIRHQQHTEIEESMMQGFTVGDFGTARSLFTFGAGIPPALHQVDMMDGPREDNDADDYVDMIGDAEEVEAEGEMRGSHRHAVVEENEEAETGFSVEMPPFLLRGMPLVSGRNTGVPPAQHPLGGQSPQQAGAPATVLDILRLIAGHHTPQARTRSGGSGLQQPVRGSGQRTALEEGMMNLHNLIGVLQQANVMQSMGLDHDIDDMTYEELLELEERIGNVSKGVPPALLDSCMKPLRGASIEAGTCAICQEELSGTFSTATADAATTATSPSNTDKACVKLLNCSHAFHKVCINQWLTQSKMCPICKVEVLPKPASSSPSASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRZ1</accession>
    <name>A0A088RRZ1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Translation initiation factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_250420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DENR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699614.1">
        <property type="nucleotide sequence ID" value="XM_010701312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRZ1"/>
    <dbReference type="GeneID" id="22575690"/>
    <dbReference type="KEGG" id="lpan:LPMP_250420"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_050010300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_250420"/>
    <dbReference type="eggNOG" id="KOG3239">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277199at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11607">
        <property type="entry name" value="DENR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000024">
        <property type="entry name" value="Translation_initiation_factor_SUI1_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050318">
        <property type="entry name" value="DENR/SUI1_TIF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046447">
        <property type="entry name" value="DENR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048517">
        <property type="entry name" value="DENR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789:SF0">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21023">
        <property type="entry name" value="DENR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="3">
        <location>
            <begin position="205"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN98907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="298" mass="32667" checksum="9BCC3FE2CF8854CA" modified="2014-11-26" version="1">MGRNKKRSKAVAHAQSCSDEEREEEHDAASTAAATAYAEGSKDEAGAPAAAGVATATSVQHSGHGSERGSDCAASAPQGKKKEYRGNRLNKLDNQRSKGKGKNASVGDKADGAAAGERNGGDDEPLIVTRQRAVEVLYCPICTFPAEMCEFSGMVEKCRPWLLEHAADLADAEERGRRRRILTEKDRLEALLEGRGIKKALDRIVVLEVEKRTGRRMTTSVFGMDLFGFNLKDVSKDWRKRFSCGAGVRAAEEGKHQDCIDIQGNVVDQLAEMLITKYKIPKESVYMMEGKKRVPYPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RS92</accession>
    <name>A0A088RS92_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Attractin/MKLN-like beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_242060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699545.1">
        <property type="nucleotide sequence ID" value="XM_010701243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RS92"/>
    <dbReference type="GeneID" id="22575615"/>
    <dbReference type="KEGG" id="lpan:LPMP_242060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240027900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_242060"/>
    <dbReference type="eggNOG" id="ENOG502QQ74">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250130at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056737">
        <property type="entry name" value="Beta-prop_ATRN-MKLN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23244:SF498">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23244">
        <property type="entry name" value="KELCH REPEAT DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24981">
        <property type="entry name" value="Beta-prop_ATRN-LZTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Attractin/MKLN-like beta-propeller" evidence="3">
        <location>
            <begin position="10"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN98838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="370" mass="42315" checksum="0989AD543BC2F3BB" modified="2014-11-26" version="1">MPRPTPPFRHWSLVDCPSEESPLGRIGHSFCANADGSKAYVYGGVNDTDSVSIYLDDLWQYDVINKRWKEIELRGEKQHPRAFHTAVWYDTCMYIFGGCNGRGRFNKLFYISEDGECHPVVVRGALIPMTRYCHSAVVFGNTMYIFGGKCGGRNSNKRLQDLYRCDLSDPEWKECNQLGTIPPPRSAHTAMTYERTMIVFGGRNSGGECCEDFFVYSFDTSVWRRIDLPHVPMFGRARNSAAVHYGNIIVFGGWNGKKKLNDLFIYNVEANTFEFMYDIDREYPSRRECHVAVVCRNTMVVFGGRFRGHFMNDTTELYLGSKTGIDSMRDWLITANPQLTGLAPHLPLHHFVALKAHKEYVVPELPEEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSH9</accession>
    <name>A0A088RSH9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA helicase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_210640</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698851.1">
        <property type="nucleotide sequence ID" value="XM_010700549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSH9"/>
    <dbReference type="GeneID" id="22574886"/>
    <dbReference type="KEGG" id="lpan:LPMP_210640"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210011100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_210640"/>
    <dbReference type="eggNOG" id="KOG0331">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10256233at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF19">
        <property type="entry name" value="NUCLEOLAR RNA HELICASE 2-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="100"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="402"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="231"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN98144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="696" mass="75330" checksum="72E72EE6707561E9" modified="2014-11-26" version="1">MSVYSWETAGGAHRSRNKVKRTGTVVFHVDECVDTTFDRLQREVIVEKLHFSEKKTEEALADPHHHANSVKTALMTASTAKVLRQKMKFDGLLPCQAQCYRGIFNGRDVILHSRTGSGKTLAYALPLIERHLLLEQHQQHADTSVAAGPFLVVFVFSNDLAMQTKSVLEKIYGRQTSLRIAVADFDDLHPSPDGKVVDILVGTVHSIDEAIRGHRVAAAATAVEEAEVQQEARLSGRKRPRSARQPQQVTAVAAGEDEDDDDGDAAASVSDEDETEAITGHGARREAGILSPARVRAIVVDEVDTTLGPRFSAVGRRMKNLLKFIRRENGSLADGLLSDFRAHHYVLCGATIPNWVLKAGFLGVKKYYYQLITVGSAKLPPQLECFHETCSVADRVRTAARLLKENVTFNGRVVVFGTLKQLTSLEASLHTATSVKACATEAKKAPLPSMKKHDKKGDRKSTSTVAAAVSSSQLSSSSSLVVRALTAQKDVPDRVAAIEDFNCGVAQVLLCTDVAARGLDFTEVDTVLMLNLPRDALASDTFVHRAGRTARVGRPGRCILLHDTSEAAVMDAIAKSTHVVFKALGPALIATAGVSADAQKGGNDKASNAANAGASGVALVSMKLVVRNSFRYTKPNVKVPPAMHVLNANVDEPLKALLKDIHEEGGSNGEVVVFRVPVSHVHEVKQRLWKYTLQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSR6</accession>
    <name>A0A088RSR6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mitochondrial structure specific endonuclease I (SSE-1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_211970</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698981.1">
        <property type="nucleotide sequence ID" value="XM_010700679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSR6"/>
    <dbReference type="GeneID" id="22575019"/>
    <dbReference type="KEGG" id="lpan:LPMP_211970"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210023700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_211970"/>
    <dbReference type="eggNOG" id="ENOG502T6EA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275278at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033567">
        <property type="term" value="P:DNA replication, Okazaki fragment processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09898">
        <property type="entry name" value="H3TH_53EXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000003">
        <property type="entry name" value="DNA polymerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000065">
        <property type="entry name" value="Mitochondrial structure specific endonuclease I (SSE-1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020046">
        <property type="entry name" value="5-3_exonucl_a-hlix_arch_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020045">
        <property type="entry name" value="DNA_polI_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038969">
        <property type="entry name" value="FEN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42646:SF2">
        <property type="entry name" value="5'-3' EXONUCLEASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42646">
        <property type="entry name" value="FLAP ENDONUCLEASE XNI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01367">
        <property type="entry name" value="5_3_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02739">
        <property type="entry name" value="5_3_exonuc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="5'-3' exonuclease" evidence="4">
        <location>
            <begin position="3"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN98274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="297" mass="33666" checksum="9E6FF01F5D0FE7D8" modified="2014-11-26" version="1">MPVREKAIVLIDGPALVHRWYHRWSYTKERYGTPIDVKQFAIKNARFMIATAHSFDPAHMAQHLLSPQTEYAHTPKHNKIIVCFDHGDGGRRQIYASYKANRSERATTPEFRLIERVAKKVFADEPRESLLVVPDCDAGLASLNAEADDMIATLAFFNQQSRRPTVVMSHDYDLYQLVDEARKSYHYDIRTKHLVSERSVMERVGVPPKLVRDFKSLAGDSSDNIPGVSGIGKTRACNLLKKYGDLDGILFKGVKSETGHLGELLSEGAKMALLSRQLIDFRMCPKVIKVCETFMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RT07</accession>
    <name>A0A088RT07_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_261390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699959.1">
        <property type="nucleotide sequence ID" value="XM_010701657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RT07"/>
    <dbReference type="GeneID" id="22576042"/>
    <dbReference type="KEGG" id="lpan:LPMP_261390"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260018900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_261390"/>
    <dbReference type="eggNOG" id="KOG0714">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000107">
        <property type="entry name" value="Related to DJP1-DnaJ-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050817">
        <property type="entry name" value="DjlA_DnaK_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="407"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN99252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="538" mass="59762" checksum="C258BCACDEB29010" modified="2014-11-26" version="1">MVMLNHRVVLFATPMHGVELAGLLFTDYICSSLLQMDIAEALSDVNGWLAFFRSGFNPSTLLSFYSRLISERLLLRLLECGVSALCMHSKFKLCKDALAFHCMYAIVRDYRYGRLWCTRLLRFAGQFLYPSFLRQSEGGSSTSSSSSATSRPTAPSLMRGGAVSNTAPKPFTESDLVDSEVAFYRNPTRPSRTKPFEAMPKPCQDALRYYLYSYQSRPFYTVFVSGLIADATLFAAEQIVWCSHFYQERTKRTSRWRMLKPFVADLVMVSAQATLVYAARVAGVLIGQRLSREPTGGGIFWGERVTLLLLSPGIQHVSLIAGRAVRDALERRHPRTVEDEEEDKRVEEESEEVARAQAAAARAAFAFTSVPLGNANGDAAKDSNDAGARVGAGGSGHGGTLEHNRINYYEVLGVTMQSKVPEIRKAYRAKALLNHPDRVGKNPVAQEQARQQMSIINEAYDTLIDSEKRAQYDVMRRFSEGPELFKKLESMTTVQLAAVSTVAVLGLGVLTVASAYGQYLTIYQRMTSLGRSPLMLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTF9</accession>
    <name>A0A088RTF9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_270600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700149.1">
        <property type="nucleotide sequence ID" value="XM_010701847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTF9"/>
    <dbReference type="GeneID" id="22576236"/>
    <dbReference type="KEGG" id="lpan:LPMP_270600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270012800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_270600"/>
    <dbReference type="eggNOG" id="ENOG502S5A8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273496at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="262"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="467" mass="54442" checksum="8E4CD91EC57ABF72" modified="2014-11-26" version="1">MVDYHLPALTATNGKKPIPSPKKKTDDHILCQEYAGYIAQLRGLLEETTGQPPAGVRTAEVERRIALIQSALEEVERLNANTRWRIEHDKAQRVLDTYKRRINAEEEAEKRLQDAEKQRTAQLEEARSLQLAYYKNRNDRIEAKAHQCRAHNEQMQEQTVMKASSKEERRTRNLANLDAERQRTQKELHDREQARQDYARKLRERQAAKDAQTLAEKARLAEIRRQEREAKLCAICESKRSKWMAKKEASSSKSVVVWKNGEAILETKLKDHNDLVEELEQRRLQQESRYAEEKAELEAYIQQRRQIHAVRQERQRENLRKLVDKRVTRGVEIVKAAEEKKERAEQAKERQVMQYVKAGKLLDESVRLHRERVQRLQDRRTNESLAQHYRRWNHRAARIMEELHDAMAEEETRIKAEAEQHGAAATNQRGSAAYADNQCSWGSGPHVAAPQHGYQIVSLPSPTEFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTH5</accession>
    <name>A0A088RTH5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ER-Golgi vesicle transport protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_261860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700005.1">
        <property type="nucleotide sequence ID" value="XM_010701703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTH5"/>
    <dbReference type="GeneID" id="22576089"/>
    <dbReference type="KEGG" id="lpan:LPMP_261860"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260023200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_261860"/>
    <dbReference type="eggNOG" id="ENOG502S55Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="246486at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="321" mass="33849" checksum="9CA74D417C76ACC4" modified="2014-11-26" version="1">MSLESWAVAAVAIVDADGTPLLLRTYTSPKDVLNSPAAPLHAHLYVGPEDTVKLHFVLFASLDRCEEMREGAAPSLTDIAASSSTALVRGSTEASLVTKSGVATSTEMGGAAGTSLVTLSNSITASIISASAANTARLISPTTDARFLGKLLDSHRMRSYGFRSVTGVHTLLVTVGSDAPADAMVPLCRALYECASATLCNPFRSPAQCWRAQERLLWRAPSSGLRCDPAGVATSQRAEETEGTDEGRECSLRMHSKVAAAATSWHSLPPGVMEWSWPRPAPTSAAALTAEPTLALSRTFNTQIEGLLSSFTVTARSCIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTS1</accession>
    <name>A0A088RTS1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Electon transport protein SCO1/SCO2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_261930</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCO1/2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700012.1">
        <property type="nucleotide sequence ID" value="XM_010701710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTS1"/>
    <dbReference type="GeneID" id="22576096"/>
    <dbReference type="KEGG" id="lpan:LPMP_261930"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260024000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_261930"/>
    <dbReference type="eggNOG" id="KOG2792">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270009at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02968">
        <property type="entry name" value="SCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000013">
        <property type="entry name" value="Blast:Protein SCO1 homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003782">
        <property type="entry name" value="SCO1/SenC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151">
        <property type="entry name" value="ELECTRON TRANSPORT PROTIN SCO1/SENC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151:SF25">
        <property type="entry name" value="LINALOOL DEHYDRATASE_ISOMERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="3">
        <location>
            <begin position="94"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR603782-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR603782-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN99305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="286" mass="32869" checksum="E392CD5C8AC8222E" modified="2014-11-26" version="1">MSEAVDEMRDNPVWMLWALGFLTLGVMTVVISIRIRREQMRFDPKLRAVKSFDSPEGPSIGGPFSLVDVKTGKRITDADLKGKWLYIYFGFTNCPDVCPEEMAKMARVINHLDKKVGRDYWQPIFISLDSKRDTPAKIREYLSDFSPRIMGLVGTQAEVEEAARQYRVYFAIPDEEVMSEDDYLVDHSIIMYLIDPEGRFSDYTTKEFQWFESYSKLLRRMMDYERHRATEEQQRVQRGEAPLADGEAPANLKIANLASMLDNAEVQAAQEAALRNQPKGLSSLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTV6</accession>
    <name>A0A088RTV6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosomal membrane like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_240140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699356.1">
        <property type="nucleotide sequence ID" value="XM_010701054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTV6"/>
    <dbReference type="GeneID" id="22575423"/>
    <dbReference type="KEGG" id="lpan:LPMP_240140"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240006200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_240140"/>
    <dbReference type="eggNOG" id="ENOG502SB3Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276334at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008733">
        <property type="entry name" value="PEX11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05648">
        <property type="entry name" value="PEX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN98649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="220" mass="23566" checksum="223FB5B31F4C4A9D" modified="2014-11-26" version="1">MSVVAALNTYMAATDSRDKMIKGAGCFFKMMGAINGNSNFMKTGAAMSDARCIMRMLSWLGNVQKISDAMEKRVVQLRDVLFVLRVLFDGIFSLLDNIVFAGRFFDNNSPTLAQMSHVSRASLFYGYAMAVMLDIYDLVRDPNMPKRGDRCLVLTRNTCDMVSAIGNVCAVDIGAANVAGLGLISAIIATREQLIAAAAKSGGSCVGASPVKAAALQPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RU48</accession>
    <name>A0A088RU48_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_272530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700339.1">
        <property type="nucleotide sequence ID" value="XM_010702037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RU48"/>
    <dbReference type="GeneID" id="22576431"/>
    <dbReference type="KEGG" id="lpan:LPMP_272530"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270033400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_272530"/>
    <dbReference type="eggNOG" id="ENOG502SA3Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265023at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="137" mass="15457" checksum="42FB4E43597F6FA6" modified="2014-11-26" version="1">MPTKRVVAKRSAEVPLHCTDADGPSLIQHTAVTAVANDGITLTAAAVEEAAPKVIMSKAQRRKLKKTPIVVTAEMKEQAREETRELRKHLRMLKSNGARRKVAKLCKKRSREYNIDEEAVNAFDTDYRPHKKGRRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUA8</accession>
    <name>A0A088RUA8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lytic vacuole protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_272240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700310.1">
        <property type="nucleotide sequence ID" value="XM_010702008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUA8"/>
    <dbReference type="GeneID" id="22576402"/>
    <dbReference type="KEGG" id="lpan:LPMP_272240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270030700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_272240"/>
    <dbReference type="eggNOG" id="ENOG502S5BF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264407at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035493">
        <property type="term" value="P:SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157:SF5">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="222"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="494" mass="53692" checksum="40DE01C62DF262A6" modified="2014-11-26" version="1">MAPVSDTTPSTTASPSGIVPTDMCVHRCQVDMRDVVYAGSTVEEADATLSRMLHLEQQQQQQQLQTRCGTRPIVFLRCTDGIFVPRVCLSDVSAAATALLEEMRAARTRTFAPPPTVAELQAISPFPIKLHTTTGQTSITATAAAISAACEELPWSRAPSSVGWRYPPTAVLRAGPLRVTMGDVKAAALTTVAWQRLADLTEARQSKLAVDLNREATADPLKRAQEAQCAGLRVQLSAAQEQLTLSALELEALREQVEQRQRQLQRQEEAHAKLQSYQAYTASSDVREQARATAHEEEAQRARLRAQLARSRQQRARELCLVYTVELSSQYANDACTRAADAKDHINKCALPIMFAGRADTDTASHLVASTAEDMHEEAVALGHAGHLLVVLSVLYSCALPYPILLGSGQSHVLSSPNISAEQVLAAPYTLTEACKYPLVCHKVAERPLMMAGVHLLLQDGIVLAKAMGKPERRVLACSDRLGALLDLLLRNVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUD4</accession>
    <name>A0A088RUD4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo-keto reductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_272440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700330.1">
        <property type="nucleotide sequence ID" value="XM_010702028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUD4"/>
    <dbReference type="GeneID" id="22576422"/>
    <dbReference type="KEGG" id="lpan:LPMP_272440"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270032500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_272440"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000056">
        <property type="entry name" value="Aldo-keto reductase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="33"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="371" mass="40714" checksum="A354CA527278A0F0" modified="2014-11-26" version="1">MSANVLAYRPLGGPVSAIAYRIAMRDGYTIPQLGFGTYRMPASEATDAVAFALSCGYRHVDCAKAYGNEAAVGAALAQALRDRRTRREDLFVTSKLWPTDQHPDHVEAACRATLAALRLDYLDLYLIHWPVCLRHTPHWTTDEDRYPRHPDGTPAIDTSVTLLDTWTAMSRLVDCGLVKSIGLANCTTAHVNDLARAAAAAELPHLPVLNQVEHHPGIVDGDLVGCLGFHDMLLAAYCPLGMPTRDTPPGFQSLLDDPVVQSLGEFSGFSPARILLNWSVDRSNVVIVKSTNREHIKSNAKAARFALDDRTRLVLDNYHLLVRNFRVMNPAHFSADGTTPFFAAEDARLQRDIDARRLKTGSTTAPPTPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUQ2</accession>
    <name>A0A088RUQ2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Structure-specific endonuclease subunit SLX1 homolog</fullName>
            <ecNumber evidence="11">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LPMP_251360</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms a heterodimer with a member of the SLX4 family.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the SLX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="11"/>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699706.1">
        <property type="nucleotide sequence ID" value="XM_010701404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUQ2"/>
    <dbReference type="GeneID" id="22575784"/>
    <dbReference type="KEGG" id="lpan:LPMP_251360"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250019300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_251360"/>
    <dbReference type="eggNOG" id="KOG3005">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="24645at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10455">
        <property type="entry name" value="GIY-YIG_SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03100">
        <property type="entry name" value="Endonuc_su_Slx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027520">
        <property type="entry name" value="Slx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050381">
        <property type="entry name" value="SLX1_endonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208:SF13">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 11" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 11 14" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 11 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GIY-YIG" evidence="13">
        <location>
            <begin position="4"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="154"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIN98999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="701" mass="74884" checksum="44610E6D6A0909B2" modified="2014-11-26" version="1">MDTRFHCVYLLTSLDPQCEGDFYIGYTVNPLRRLRQHNGELVNGARRTSRRGRPWTIVCCVSGFTDDRAALKFEWCWQHPTVSARLRNTIDVLTGLRRLPYAVATLHLLVRASLFCQLDLTLHIFEPALLQEATARAEVFLATRRGALAVGRGLRVESPRASPQQHSQRSASVPGQADDNATPPPPALDSQGGLQDAPLSSTLATTTATSRILPSLTPSLLFHVEATTRQAFEDAYLSHDRCLLLPGVGTSVDLRGAEKGGSPMSATAGSFCPYDVSLLCEAVRAEWSHASFASDSDDEGTRRLAPYCRTAASRTPSPQRVCTESMPDLLGYRSEGRAGDSDLEVYSGSSLGCGAASRSFSSPPSPLESSQLSTSCLPLPPDVNASASFVVDALHDSVPAAYLSTTAAAPTPQPRIPLRFAGHGEVDFARAHAEEQNCLHHGLLPCSLCALPLQPSVVAYCSRAPFCALRCHLSCLAMWMLYSEAEAATTVDGADTSPAPLSQAPPAPLSPLRRLIPSQPCPCPLCGVLLHWGPLVKALKKRVVVERRLYAAQRRIRMEQRWQARLNHINTAKRGTGAATRRGPRTRVSAAALLKGGEEAVRAASTTAVPTIHAGQALQNKRRVRSPSSLGEPPLAPLAAAASCPSPSISFAASSPTASASAILCHHGALTSATGTNTTVAAMVSDASLLSLTDFCEDDWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RV55</accession>
    <name>A0A088RV55_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Membrane-bound acid phosphatase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_282810</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700620.1">
        <property type="nucleotide sequence ID" value="XM_010702318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RV55"/>
    <dbReference type="GeneID" id="22576726"/>
    <dbReference type="KEGG" id="lpan:LPMP_282810"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280034700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_282810"/>
    <dbReference type="eggNOG" id="KOG3720">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="258392at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF110">
        <property type="entry name" value="2-PHOSPHOXYLOSE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839133" evidence="4">
        <location>
            <begin position="38"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="495"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN99913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="548" mass="59178" checksum="74AEF841810752C9" modified="2014-11-26" version="1">MPAVLRSPLPRSVRRMAVLAAATALLAAVCLPAPARGSVEWVLQQVQVLHRHGSRSAVPSYNATDICGSTPCGELNPEGETMVRNVGEFLRARYTADATVVDAPFLPSSDYDLSVVASRSTDVRRTLQSAQLLLAGMFPNAIRLIPAIHTVPTSQDTMLYTFSQPWVALYATYATAAQQARTNPVVDHYFPDWTELRGLAAEVWSEGYCSNYETRLNCAIMLFDIAAAKRSVGKLPAAVAARYDDLHAIIAEWFRGMWHYDASNPFLVQQGGRGQPFLQQVLTNMDDFIAARSTYKVMHYSGHDISLAAVWGTLGDRSAYAMQPTYAQTFVLELLKSATTGEYGVRVLRGWPGQTPDTGFTFSWDPTWQLRCRGRDETNYAATDNLCPLEDFRRYVTWTVGTDPRGMCLLDVATSAVLNCPTAEAEQTVGVALSESCSLYRAVCPQYACAPGYVLSASESRCTCASAACLVSRGSEGKANVSVTVSMPGVSRGTAAGIAMATFSAGALLAVLMTLIALVLLRCSGGSARYSGPCGKCVARGEPTREAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVA2</accession>
    <name>A0A088RVA2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_290080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIN99958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700901.1">
        <property type="nucleotide sequence ID" value="XM_010702599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVA2"/>
    <dbReference type="GeneID" id="22576772"/>
    <dbReference type="KEGG" id="lpan:LPMP_290080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290005800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_290080"/>
    <dbReference type="eggNOG" id="ENOG502SPSP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270382at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="113" mass="12473" checksum="86AC5E5A3074D9A7" modified="2014-11-26" version="1">MSHSPFLTALYEDVRIRLPLWTTQYVNFVSNAAFAVSSTWIDDSGAKRQYLFIPVEASDSNSISAAALAEWIALVEVWQAAHREDDVSCFVGFVDLAGTVSYYRCETAVASAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RW58</accession>
    <name>A0A088RW58_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_271220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700211.1">
        <property type="nucleotide sequence ID" value="XM_010701909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RW58"/>
    <dbReference type="GeneID" id="22576300"/>
    <dbReference type="KEGG" id="lpan:LPMP_271220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270019500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_271220"/>
    <dbReference type="eggNOG" id="ENOG502RX82">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270746at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="451"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="518" mass="59627" checksum="9663C0B6B29411ED" modified="2014-11-26" version="1">MGVASAKPAREAPVRYVAKKMPRVDKNPVEKQFTKPQFTALGINTRQDDVNTEPLMYVETSKESSSTELTDHVAPRWYLNTYLEMSDNMRTDQTVISGNLPLAWERDKHEPYSLVRGRIDDEDLRWVLHPEQRKKPLDELLGHTKLERQVLQDILDTVELPRTQYRNYKGKLHKSIDDANTHMTARKAQIEKAREAEILRQIGYTKEEVLKEEQYLTNRHRGVRALDDLGASDREKRRQQRAAEASELEDMLEERRIEQLERGEAVVMAEEVTEKPEVLPMRKKLFSTRSNTYKHMYAADIGKDERNQAKFVWWLDRTRRIKRAVDTIHGVPVYNERLSANEEQTRKQMQEAAEFNFSMSRSQGAKGFTDPRGHYDQFMDIMRHNKAEMQSETNVEVHEDNSTEHAVFQFPHTREHGAKPAPTRFTDRRDHAQRVDTDVTKLFGLEHEPHAATPATSAAPAYRESSLPKQSSSGNDGLAYPSRRAGTGGWEKVKGADGSTPGVRTDASHPTNKDDRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RW64</accession>
    <name>A0A088RW64_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_301780</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00403.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701203.1">
        <property type="nucleotide sequence ID" value="XM_010702901.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22577231"/>
    <dbReference type="KEGG" id="lpan:LPMP_301780"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300022000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_301780"/>
    <dbReference type="eggNOG" id="ENOG502QQ4F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="442692at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904158">
        <property type="term" value="P:axonemal central apparatus assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031549">
        <property type="entry name" value="ASH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033305">
        <property type="entry name" value="Hydin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053879">
        <property type="entry name" value="HYDIN_VesB_CFA65-like_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23053">
        <property type="entry name" value="DLEC1 DELETED IN LUNG AND ESOPHAGEAL CANCER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23053:SF0">
        <property type="entry name" value="HYDROCEPHALUS-INDUCING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15780">
        <property type="entry name" value="ASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22544">
        <property type="entry name" value="HYDIN_VesB_CFA65-like_Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO00403.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="5554" mass="590535" checksum="C4BA5890D530A14F" modified="2026-01-28" version="2">[encoded data, 5554 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWI9</accession>
    <name>A0A088RWI9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_272350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700321.1">
        <property type="nucleotide sequence ID" value="XM_010702019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWI9"/>
    <dbReference type="GeneID" id="22576413"/>
    <dbReference type="KEGG" id="lpan:LPMP_272350"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_272350"/>
    <dbReference type="eggNOG" id="ENOG502S74T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="262426at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="159" mass="17515" checksum="998BDA7EA5A1211C" modified="2014-11-26" version="1">MSQGNEDWGDMVLPGVYMIQRSTGAGMTSGTVRPDKTVNLELVHLQIDETKKYVELLEKSNKDIATYLKEQRESRSTEEGGGGAGSMIALSGDMEEEDNDSVFREALEENELVIASKKRELEQLRALIGGQRCGCSCTHTQHHDPQSITAPSSETRISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RX67</accession>
    <name>A0A088RX67_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_282210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700561.1">
        <property type="nucleotide sequence ID" value="XM_010702259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RX67"/>
    <dbReference type="GeneID" id="22576666"/>
    <dbReference type="KEGG" id="lpan:LPMP_282210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280028400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_282210"/>
    <dbReference type="eggNOG" id="ENOG502QQEI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5527234at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052299">
        <property type="entry name" value="CEP76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028926">
        <property type="entry name" value="CEP76-C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056288">
        <property type="entry name" value="CEP76_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056289">
        <property type="entry name" value="CEP76_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056290">
        <property type="entry name" value="CEPT76/DRC7_peptidase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46436">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 76 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46436:SF1">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 76 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15627">
        <property type="entry name" value="CEP76-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24652">
        <property type="entry name" value="CEP76_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24654">
        <property type="entry name" value="CEP76_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24656">
        <property type="entry name" value="CEPT76_peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CEP76 N-terminal" evidence="5">
        <location>
            <begin position="18"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="CEP76 C2" evidence="3">
        <location>
            <begin position="95"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="CEP76/DRC7 peptidase-like" evidence="6">
        <location>
            <begin position="345"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Centrosomal protein of 76 kDa C-terminal" evidence="4">
        <location>
            <begin position="485"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN99854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="627" mass="69360" checksum="A5FB9AB442A84795" modified="2014-11-26" version="1">MDALQGSGQVLPEYLKSMKSAIHSFLQETGVYDSIRDIVDTYISEHGDESVSSENPSAIMQIVKEKGILQELVNQIQSRPTVGTVPSITIPSDGRYYLLVRLNGGRAFVDNLDLAPSTLCKRSVVFAAHFGNQRFRSAAKACSAEPIFDEEFLFEVDATRFGFGEMDLIEVSTPFHIAVLREDAQLNVAELLGENIIEWRKVLKSGYLGLTVELCGKNAGIPAGIVDLQLELVSKKRIRYKEEDIVSRAEQQRIAVTNADREFLVYSRRWWSEYQGLRPTHKERKVRLFASTSTGRMVPLTHFVSPIQAEFGIHSPQDAARFVSLLRVTTMGTGAIGALCVEESSWLSPFIFLSQRQGHHCNHATLLCSLLLGFGIDAYCAIGSCNNGDIGVFVVSRSTDARGSAKVTVWNPTSGERSSPSEQATFATIDCMFNSKSFFANCQASNSIATASFECYNEEFWKPLNVLKLRMVPRYPPAPLLFETVVASSMERSLEIQLREAISTYRDSFGVVTTYDNTVSYVLSQALLLYERQQSEGSAESFALFQESVKGTLGVGKTFKAIPVNVSYLDAGSVMDVVRAASVGREILDMVVDSAKFGVRVKVFCFPERVFSVWVMIAVNYSAANVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXC3</accession>
    <name>A0A088RXC3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-ketoglutarate-dependent dioxygenase AlkB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_282870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700626.1">
        <property type="nucleotide sequence ID" value="XM_010702324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXC3"/>
    <dbReference type="GeneID" id="22576732"/>
    <dbReference type="KEGG" id="lpan:LPMP_282870"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280035300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_282870"/>
    <dbReference type="eggNOG" id="KOG4176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28127at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032870">
        <property type="entry name" value="ALKBH7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052:SF0">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052">
        <property type="entry name" value="SPERMATOGENESIS ASSOCIATED 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="32481" checksum="851F8C8CC4A87367" modified="2014-11-26" version="1">MRSVSRRLLLASPATTIVAAPQSLLSMRGAPSFVHPPAEEAIGKDVKATPANWVTAYVLPEVITEPEEQALLDFSEPWFKRLSYNDGHMDGLIHHYKEFYRSYATIMQAAETGNDPGLSTPHANLETDLSLVSGALARVHNLAQVYLPRIPIDDRVHFLRLAGSGFIRAHADETRNSAGIVAGLCLNAGRVMTLTHPKHPGEHVELMLAPRCFYILLGRARYDWEHSVDWVCDDDEHIRRIQKSIVVEGTPIRFDGAETPYRRFDRTAIIFRGISPMALLARRMHERRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXT9</accession>
    <name>A0A088RXT9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_291400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700747.1">
        <property type="nucleotide sequence ID" value="XM_010702445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXT9"/>
    <dbReference type="GeneID" id="22576904"/>
    <dbReference type="KEGG" id="lpan:LPMP_291400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290018100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_291400"/>
    <dbReference type="eggNOG" id="KOG0145">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266020at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000835">
        <property type="entry name" value="RNA binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="218"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="316"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="632"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="849"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="655"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="677"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="714"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="871"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="889"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="912"/>
            <end position="923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO00090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="923" mass="95459" checksum="FBDE7B1B6129DA66" modified="2014-11-26" version="1">MMKTGSVKPIVTASPMPIDVEQQQQPHPRATSASSPSTPPISATKLRQSAGGAAPPSNQSLTSAPISVGGGGAYEGFPGTLVSSVQSPDVLRSSFVPAKELTLRQYTLQQCRADAIPGRSPTNYGTSGGVAGSRPVPTLSVERLGEPVLMPGLPGTAAGAAIGMCFVTPISGVLDAPSTPPSSTTTPANMTFSISEYPGVMTTSPTPTPMTPTEHSSTNLILYNIGSHMTEAALQKLFDPFGEVVSCAVMRDIHTGVGLGTGFVRYSDHREACRALEAFSDRMNPVCAHDSKPLVVQWARKQHDCAPAGEARKKIMKLFVRNIPLDCSIADLEELFGVYGGVRQVTLHKDTSPVQDETMMRLIAFVIYTEEGAAERAAREVHNTKPFASCHGIPIMVKLAESSQRRRFMKNSEATGPSLLTAVPAGFPGSRTSPMTPGMSGSLFDMAAEAQHQQLLQQKPITPQQGMFEAHGVDTPPSSYRMPVFGCTVAYAPPDPRETSISCYPGTPQPLQVSVSGGGTPATVASIASNMMGGSPGRYHQQILTHVGEREGRVSPHSSSAAAPMQGHSYQQAASLSFDASAAAVYSGLSAFSKSNCQSFSDGRTGGSSGGVCPSRGFLHCSSSPGDANTTAVTAAADGGSPQMPASGPWYETTDGGSNQSGSFMMSAPPTRRGAEATRSPPAPTATSATGSAPPPGSLRSGSTLSVAFPSARGSPQQSTGVHRTSPTSKPVPGGVPTSHPVPGASVPIGGQMNVALQPSTKLSILRSASTSDMSSVIPSNNFGSGTAPLNGAAHKTESPTIHTDASESWRRAVRTHVHNVKRQNDLCNVSGSLSSISLIKPSCNVLAPATSSPTAAQEGGMLSLSGNEASAPGTTPSTSPISNSTLSGDQTGPKSIGTGSPSSGRMRYYNNPYSSESTKLFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXY9</accession>
    <name>A0A088RXY9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cleavage and polyadenylation specificity factor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_321420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701828.1">
        <property type="nucleotide sequence ID" value="XM_010703526.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22577883"/>
    <dbReference type="KEGG" id="lpan:LPMP_321420"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320019800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_321420"/>
    <dbReference type="eggNOG" id="KOG1896">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6109at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001474">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="5">
        <location>
            <begin position="15"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="6">
        <location>
            <begin position="698"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="4">
        <location>
            <begin position="1169"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="178"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="231"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="245"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO01028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1536" mass="166901" checksum="55BA64D4AD249309" modified="2014-11-26" version="1">MLHTAVAPSLPASVVTHTVSGYFLPDSLAAQKEKEVVVIRQNHLTLYRVKEAPHSYVAAGLSSVEQLGQVAEVSLHAPPLAAATCRPLRAASDIVVLLFDDFHVSFLQYSPVTLQFNTVALVQLDDRQLSLDRCPLSAMLRVDETGTYVAVLAKRSDLFFFPVMEMMDQQAMAQAQAQAANAAAHTEPKPAAFAGSEETGVTTPSGTTAAAAQKPTVALNAWGDEDDEDNDKAPHPRTHLEAPNREQSAPSKPMTSDESNVAPGTASSEKVRQAGGTSLLLRIGSVTHWCLQEVKGALRNIRDVQFVASAGEPLLAFLFEKQPTWAGRVKLLEWRSKTVESHMLTCSIEWMKVTLANTAAPHMLSLSEVDGLPYDATSMTPLPAFQDVPSAVLCVSRNMMVHVSTKSGYGVYVNAMGEEQARSLKSSAVSSEALQWRNASQATSTDLVKVNLNFANATSVLLSQPTTPGKALAVSTAAASASVGNHSQRLLVITEEEGTVVEVHLQSHGYSVGSISAEIVMTGCFCSSYAAIDATRYFLGALNGDSRLIAHTPRDPCKVLQKFVGLGPVRDVDIVDTTSTAAPLGGEDDLHDSSVETSPYADLFRTVELEAEPTMTPSQRKAVMDIALCSGSGSAGSLSILRRSIRSRVVRQEELNAISVFFLEPANPDARKRQRDVVDESERGDAPSASLVGAGAVLHSHLLISGTNFSILFAVRSDSVQQVRGAALSVAARTVYAVHVDWMPGLLQVTETELRLLSGDGKRRLASTEFRTLPAIQQASSQGAAANLAVSALLVAEMRCVLVRFTDGQLLSFGLEDAKAMSTAALLLEKVTAVAWWKSAAQDPRQRQHTLVVVQSMDLIFYTLKSPQAVQRASSFPNFALIPPFAMEGVETPVVKLRERLNAEPLPTVTHLSVFDQHENAAVSAAPTEATLVMILSTGELVTYRVVPADASAPRRCVKLVYHILDVAPEVDVVESIEVRKKRLQEERAHLASVTQQMRRCSERLVPFCALQGRHKGIYVCGQTPVFLVYHYATNQLVCTRHHATSAVRGFAPFHSRHVHGGFVYCGEGFVHFATMQPFGELLGSSGWWLERVRLGCTPHQVIYSPAAHGCFVVVSRPQPFSPKRAPFDVQLRMVEDEEGNRVPHVVEPVSLPPLSATSGSPVPTNGRYEVQLFSTLDWQRVDCLALDVNEKVLSATLMQVSRDTTMDVAHRSATAPVCALATAYPLGEDVTTRGRVLLLATSQQGGQGMQQLRILHEEPMKGPVTAITRVDEDCIAVAVGGTVRVYRYDASKGVMETTAILYAGAYVTCLQAFRDYLVIGDLFHSVLFARYSEEIHTITILGRDTNSISVVSSDMLYHDTRFGLLVADDARNLMCMSYKPRLLEEPGKPPKVLESLLSVTGEYRLAGGVLLKMMRLRASAARSSSVAIYVTNMGEIGYLVPLGDQTSRTGQWVVRRLQSEVAHAGGLPPRMFLGFPQDDPLRSLKGDEWMLHFPLLEQLYRQDLRTRKLIASAAQTQLERVMNVGATVSAELGHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXZ4</accession>
    <name>A0A088RXZ4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_321470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701833.1">
        <property type="nucleotide sequence ID" value="XM_010703531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXZ4"/>
    <dbReference type="GeneID" id="22577888"/>
    <dbReference type="KEGG" id="lpan:LPMP_321470"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320020300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_321470"/>
    <dbReference type="eggNOG" id="ENOG502S6D2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271940at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="773" mass="82843" checksum="474556E87C805961" modified="2014-11-26" version="1">MIIGAPAKRWTTESVSDLLGSPYTGLGAVLLSDAVVDYLQSIQSVRTVRAARRVADGSDKDGNGGSDSLPSDVHVVLQYIVRHADTLFALLHGEARMENGFVSSKEALQGVFPTSSPTPAEDQAPPTVVEKQYPSNGNPANGPCNAPGASQAYDGSAGIENAPASASAAIGDGEEAQERRCLANLTELLSFCISHSQVQSEIDAVVAACIKALSAENILEVQRTFAVQRLLLEAFDNDFEMTTQTIADTLTHSAIKGMVKNLSSNCIVAETLIALFGSALSAVWMVKPTTRTALFTSQWIRLNFPTTFCAHLLTAIRDPGMYHYFYFFKELLKRGYSHSAGPIVDVLLSEPLVSDYVECILSCCEEDVGRTPLLSPDGVAAAPVSLAADGMEVLVSIISLVRKSLVLPETNYMYETSTQYISPVAVLQAQASRVTALLAPTAKEEAELEALVSSTQSSPRSMSGPLRHACSPAAMDGGYGLGPLRLAVCELFVEFSLFQLASTDNTLITSGFFPAFINCCERFPQHDALARALHRCILTVFQRAMLVGENLSAAAERDCLWTYLVMADTVVLRCGALESVLGSLTHLAQIPDTTLSSLCIDLLTSLSSLPLFQSAAGGPFEKHLEAFKACEAIQERVRHMATPITGGSFKEHGSAGVREAVHRDTINLAGDRFDGPKAGGFSRGSRFSGFSNRLTKGAYIIVRRSADDDRPKRPPADVVVDMEALKQEVHTLQQAGSPAVQSYPSFGNVQFGFASSAAHVEKEEQNTAETPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RY93</accession>
    <name>A0A088RY93_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_320280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO00916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701716.1">
        <property type="nucleotide sequence ID" value="XM_010703414.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22577769"/>
    <dbReference type="KEGG" id="lpan:LPMP_320280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320007600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_320280"/>
    <dbReference type="eggNOG" id="ENOG502RYJ4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272915at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="998"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="595"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="952"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1205"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1730"/>
            <end position="1883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1895"/>
            <end position="2010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1730"/>
            <end position="1742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1743"/>
            <end position="1769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1813"/>
            <end position="1831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1837"/>
            <end position="1846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1860"/>
            <end position="1874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1925"/>
            <end position="1935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1973"/>
            <end position="1988"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2010" mass="220151" checksum="292BA2B012CB18A3" modified="2014-11-26" version="1">MTSRFKQFLVTDSDEDTTLRDAQETLPQPSTEAETAQTAPQTSVTLNPASQNAFSGTQVSVETPALYEATAPVGTATHISLHTATPLNRSVASSTHFVEESVSHGVDGGGNPADLTVGTSISFQESPIPRGGAEQVSASPQSINFSAAAFSPLLSVRSDSMSARPAPKMPSRADSGYAFNASRTLAADANMSAPQEESEEPKVRAEAEQSQRSKSQLFTATTDGVTPRESGASVASDDQDKKGTKVVGRRVVERRKKGADPSDSEKLMRIDEQVIRPGRANGAASTAATPVESPRTPGGELRRLPPRVPTTRADSRGVSPLLPRRAHSAKDAQLSTRSHNSNSSVANPLLILQSSQLRRSPQMPSSTALDETSPTFTVDESGQRVSISQDDGRQTWMLRSPRRGDTAAACAQEVPPPPQKLSRRAQDTLAQKRRTLEVGVKKRRIDSTEDCVEPEKRLSTSRRTRGAFAFPAAAFYSDKVAHHHCEIAIWLQDNQWTKYVYDGMEVCTEVRRASATVTNREDTEKVVRTLQPVQVEPSVGGTGMCMCVVYDSTNEDDALRRLIDSNYAREDGVRRYLNLQPMQLANVETHQMVDPQLESPGRRSVSPSEAQSAVEPMQRSATEQRGLATLGGLWCTVEALGEDGRPAARKGMSAPRRILRICGGQALSIQLHVGSDEMFDVRCYELLLFPRESLSPSAVNYGSEGLTLGQVVAPPASSFPLTPRIIDDPVVLREYKKRLLTTKSRQVALMNFEDDCATFATEPTSSDDAGKAGGIAGQYLTLTTVTISSRQKYTIELTLVMLPFRTGGILGGKTVAEVPRFCATTVLLYRRLQGLSLSFSTKSAFMSAYKALLWATECDIVDVQHVDGEGGAVSGASYSKLRVCATTSPMVPWVASFGKSLPGQPTENAFHSNCLDFSALALGAPPGADQETNVDERDPLTLEDFVIFEGEHSAEGDDDDTQSGQIGTPGRQRRRSSIYTSTLGLPKAANTEGGSALHSADTLVGLTAFGVIRRAVSQKTSEVFDVRVMPRNRGRMAPTTWDGTAVTEEGRAAANRKTVKTQEERLLQQDAEAAIMIEYVSRLPFHSRVYGVLVDDQRYYIFQEPWVSALSLEESMKGSPEHDALMSNEMFREMTRTTAVMSLKDFIHAVLHPGVCELRPKEEVWLEIAQVLAAQLLLLVTSLHGKGMLLGPCPPQRLLVRVEDPTKGSRQAEEESNVSTAGKKKATPTPSVTSSNIQLFVPDIGVNTLAWGYERQQCGVLEYLPPMYVLEQMLCDSFGREERPWTMRDDWWTYLVLCFELFAGDGSALVTPETTAVIPTPTPTLTKFFSPVHILDVWQKVITDTTSGASGTAAKTIGLRTRRYVHQRVLKSVSRFIDSWVVAKAEEMQYFGTTAADHGRRIVRAVPLLPAVQNKPIGVSLAAMYLKSTKGVSDTSSIAFQADSDEAGDGAVENILVNMPWIFQVRDFFDTILDTVFAPTPCSVHGPALRLMSHPFFRGVQLAKVFDGSHIYSAAVADYAEKHLTKSKVQATLLDYRTRTYRGLLRLRSEMPLMITGSTYSTSVRTNTGAPLRILSSPAFCEEHAAFENEDSQARRGVEVDPAEGLVFSRTNSTAPSAIPSPRSQTSATGMWGQQRLRAIYDPAEWHSIAALETEVRGALHFYGPRESVSRRRAPAEADYPSNPVSISNRPMQPMRRHSELVQAETASMTPSGCRRNPREYEHVVDSKVARAPAAQPQRSARGSANSSFRSDATMTTSRSAFGQTNTAPLVQPLKLGAPHDSPAVSRRGIPVTAVDSVGRFQEEGTQTPRAHRYTDASKFERRLNDLEVRHPHQRRNTTLSTSSHHNNGEVATGYDPGASQRQVQSSMHGSRPSSRQDECSNQRSWPNEFLDAATVQKKGQPHRFADQKGSMMNRTTSDEQAQHSARHLGPHSRHSGQIVHSAPSRHAYQESSSEESGMWVPSDGEEDMENTPVLTYRSNDMNRKSPTPRNPRASRLQPAASDRRSYFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYI3</accession>
    <name>A0A088RYI3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">As/Sb Reductase</fullName>
            <ecNumber evidence="2">1.20.4.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ACR2</name>
        <name evidence="2" type="ORF">LPMP_322880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.20.4.1" evidence="2"/>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701973.1">
        <property type="nucleotide sequence ID" value="XM_010703671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYI3"/>
    <dbReference type="GeneID" id="22578029"/>
    <dbReference type="KEGG" id="lpan:LPMP_322880"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320035100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_322880"/>
    <dbReference type="eggNOG" id="ENOG502SNRH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="102559at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008794">
        <property type="term" value="F:arsenate reductase (glutaredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF38">
        <property type="entry name" value="ARSENICAL-RESISTANCE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="21"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="127" mass="14397" checksum="B89C7DE0FCA1D87E" modified="2014-11-26" version="1">MANYTYMNPDELVELLDKPDSFAKVAVIDCRDSDRDCGFIANSISMPTIRCSSEMYEGLAKALFDEKKEIAVFHCAQSLIRGPKGANRFALAQKKLGYPLPLVYVLRGGWEAFYNIYGHMRPDLMYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYN1</accession>
    <name>A0A088RYN1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="11">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">GCVL-2</name>
        <name evidence="14" type="ORF">LPMP_323490</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD(+) = N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="9 11">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="11"/>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702033.1">
        <property type="nucleotide sequence ID" value="XM_010703731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYN1"/>
    <dbReference type="GeneID" id="22578090"/>
    <dbReference type="KEGG" id="lpan:LPMP_323490"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320041500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_323490"/>
    <dbReference type="eggNOG" id="KOG1335">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="361797at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050151">
        <property type="entry name" value="Class-I_Pyr_Nuc-Dis_Oxidored"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912:SF151">
        <property type="entry name" value="DIHYDROLIPOYL DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912">
        <property type="entry name" value="DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 9 11" id="KW-0274">FAD</keyword>
    <keyword evidence="2 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9 11" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 11 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="13">
        <location>
            <begin position="12"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="12">
        <location>
            <begin position="357"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="455"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="153"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="190"/>
            <end position="197"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="329"/>
            <end position="332"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="10">
        <location>
            <begin position="50"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIO01233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="476" mass="50518" checksum="497073DB24952121" modified="2014-11-26" version="1">MFRRNIPYLASYDVTVIGGGPGGYVAAIKAAQLGLKTACIEKRGALGGTCLNVGCIPSKALLHATHLYHDAHANFAKYGLRGGENVTMDVAAMQAQKMKGVKALTGGVEYLLKKNKVSYYKGEGSFITANQIKVKALDGKDETLESKKTIVATGSEPTELPFLPFDERIVLSSTGALDLNHVPKKMIVVGGGVIGLELGSVWARLGAEVTVVEFASRCAATTDADVSKALTDALEKNEKMRIMTHTKVVGGKNNGSSVTIEVEGKDGKRQTLEADALLCSVGRRPHTSGLNAEAINLKMERGFVCINDHFETNVPSVYAIGDVVNKGPMLAHKAEEEGVACAEMLAGKPGHVNYGVIPGVIYTNPEVAQVGETEEQAKKKGIDYKVGKFPFSANSRAKAVGTEEGFVKVVTDKKTDRILGVQIVCTAAGEMIAESALAMEYGASSEDVGRTCHAHPTMSEAVKEACMACFAQTINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZC0</accession>
    <name>A0A088RZC0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Myosin XXI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_324000</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702081.1">
        <property type="nucleotide sequence ID" value="XM_010703779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZC0"/>
    <dbReference type="GeneID" id="22578141"/>
    <dbReference type="KEGG" id="lpan:LPMP_324000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320047300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_324000"/>
    <dbReference type="eggNOG" id="KOG4229">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14875">
        <property type="entry name" value="MYSc_Myo13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000011">
        <property type="entry name" value="Myosin 10A, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.4820:FF:000016">
        <property type="entry name" value="Myosin XXI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000154">
        <property type="entry name" value="Myosin XXI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036125">
        <property type="entry name" value="MYSc_Myo21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF706">
        <property type="entry name" value="DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0518">Myosin</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="9">
        <location>
            <begin position="61"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="8">
        <location>
            <begin position="953"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="8">
        <location>
            <begin position="1007"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="6">
        <location>
            <begin position="622"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="768"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="157"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIO01281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1050" mass="119210" checksum="BC5802ED9FE63127" modified="2014-11-26" version="1">MPERVSVNQEVYYFDPKSGWLRGTVKQVDDGKVLIVDNASHAAVTVASENVHGYISESYDPEDAELFHVSDLHVATLLHCVKDRFEQLQQQYSLMGEMVLSVNPFRRMPFNSEEERKKYLALPDPRMLPPHIWQVAHKAFNAVFVQGRGNQSIVISGESGSGKTENAKMLIAYLGQLSYMHSKNTSQRSIADRIDENLTWSNPAMESFGNARTVRNDNSSRFGKYIKLYLDPASGIVMGGQTVTYLLEKSRIIMQSPGERNYHIFYEMLAGLSPEEKQKLGGLKTAQDYKCLNGGGTFIRRGVDGKPLDDAHEFQTVCRALSMIGVSLETQNCMFRVLAAILHLMEVEFEADNNDKAQIANEETLATGSRLLCLDEAKVRECFLVKSKTSLVTILASKTEAEGLRNAFCKGLYVGMFDRLVEFVNAAIHPQGDCSNCKYVGLLDIFGFENFTRNSFEQMCINYANESLQNHYNKYTFISDEEECRREGIETLKIEFPDNSDCVQMLDAKRTGIFSMLDEECNFKGGSADRFTTNVWQQWNGKSPYFVRPKSTIPNQFGVNHYASFVNYDTTEWLEKNTDALKEDMRECVQESTDEFIQTLLSTERCEAHRKQTVAIRFQRQLTDLRTELESTETQFIRCIKSNMVADPSFLENLLVGSQLESAGVLQTIALKRQGYPVRRPLAQFCRYFYLIMPPSTVSLFKQERYSDACGDFLQRYQRLYNWAVPNYAVGKTKVFLRAEVWAGLERLVLRRRAQLLHRCKPYLHRWVEEIRERRRIEEQKRLEALRKLREAREAKAATAVNGVPAEKVQWVEEVSNMFPDFDMDTLMDVAVEADTREEVLEAILAIQADRVDKQSASGFIDVVTAANVSHDLINGFILADIKTVSALSKLQPEELKSLGASEIEVVAITKKLIHQQGQRVKYSRLAESIGRTGEDAAADDIKRAETARHRDDFDTKVQVLASMGFDESISRLVLAHYNGNVHRTAARLLYGVDSRKMKNNARKHKDFNTTNVGVQQLISLGATKHDAKMALRRSNGDTNGAATMLFKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZC3</accession>
    <name>A0A088RZC3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NF-kappa-B-activating protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_330610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NKAP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702154.1">
        <property type="nucleotide sequence ID" value="XM_010703852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZC3"/>
    <dbReference type="GeneID" id="22578214"/>
    <dbReference type="KEGG" id="lpan:LPMP_330610"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330010800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_330610"/>
    <dbReference type="eggNOG" id="ENOG502S4N6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273141at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040466">
        <property type="entry name" value="NKAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009269">
        <property type="entry name" value="NKAP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13087">
        <property type="entry name" value="NF-KAPPA B ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13087:SF0">
        <property type="entry name" value="NFKB ACTIVATING PROTEIN LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06047">
        <property type="entry name" value="Nkap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NF-kappa-B-activating protein C-terminal" evidence="3">
        <location>
            <begin position="289"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="182"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO01354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="378" mass="41212" checksum="B8FC7A6FB87AAC74" modified="2014-11-26" version="1">MEQLMCCSLEENTYSMQGFWLWQSNFIQLRRRREQRRRRPRNDTASSTEESSEQSSLTPSQTEAVSLQRANEIREYISAVLHATGYPYRSASTTDSAPEGADGPTLAPVTDAEALATSSGLMLASLSPAVADPAEVSGEPPRKTNRSEGTGPTGHTPAVAKSALAKIVAKAKAQHRDLVKHAPVVAATVPTRRTQPDETRGQPGVSRKRVQFADESPLANNSQLSRGHQIRNDNGDSDDEFTIQLPGHKGPRASADADESGGRDADAVTGVAGSADTVAAKHPSQMTRAEFLSQFKRAPRRGEVGQTAEEIAAAEKLGYVMSGSRSVASRMYVDRIQRQLHEHEAAKLQQQFRKVEDERMDDQLVLELAQLINGRKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZZ7</accession>
    <name>A0A088RZZ7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_332880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702379.1">
        <property type="nucleotide sequence ID" value="XM_010704077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZZ7"/>
    <dbReference type="GeneID" id="22578441"/>
    <dbReference type="KEGG" id="lpan:LPMP_332880"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330036800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_332880"/>
    <dbReference type="eggNOG" id="ENOG502S8WP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264300at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="876" mass="95983" checksum="CABB4BB3DFC179D3" modified="2014-11-26" version="1">MYPNSTTLAAQALPIALSPVEVERTSYALGGYDTQPAHTSPVMDATLPGQQGGSALPFLRGAGGKNGRVPGAASGVSSLLHGAQATSPSSAYPPLVGPRTQLKSMTDGTRVNCECARHALSSRCGSRDLDSARMVRPRGTSGSDHADSGTLAAHPPVLQQPTYTSYAIHRVLPRVAHPYFTTDAQYLFQHHHTSRPDSSAHAYLPPQYALSGHTSKGHSLPLSVLYNAEDVLESLVYTPPTAVTTTHLSSRKPKACDNGAASLLRARAGLDFTLPPVAQPNTAVTAPLLLQHPHRPLPYQAASLRQVVSVTPPSGAQVQRELTETEFFRQPLEAPRTAPDPLLDFTAKAPMAVNQVLLPASSANIAVVPSTLSSFSLQLEKGSRAMVSATTQQRQPHALQTPTLASPNLCGSDDGRDASGGAALCLASMFTPFQQQLRRHYHNHPFGATLPMAATLGSSDMYNKRNVQRGTWVFVLARQECLARELLEAEETNEALRCLPASCTVWRTYYRPTSGSAEHGAACLASSTGSDTLTSSGVFTASTAALGTSCELFSALDDADASCVAPRETPPPHPCGVERKVGGGNDQALVTPPPHPAFAMAVYWLELLESILRGEVRTEEGDAFRSCLEKPCEYEQRLLSVGTLPLEQFLRSWIEIHRARKLHHVHQLAKMEDMEHEARTALYAASETLQRRFQLMRTALVEQEHHYRCTLELLWTQVAAWVGVVLLRLQEQVERFPLAFGSAMSRTRVCGRVTGLNRFSNLVEVEQAFRKTIRNEEIRQRVVFPTEFEMRVVCLMYEPRARKELLKREATERAVAHQVVNALQTHYSIREVEIEESIERQFWLTQLMHSGVDLVVVESTTLPHRLRDVALTEVEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S046</accession>
    <name>A0A088S046_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_341220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702548.1">
        <property type="nucleotide sequence ID" value="XM_010704246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S046"/>
    <dbReference type="GeneID" id="22578627"/>
    <dbReference type="KEGG" id="lpan:LPMP_341220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_341220"/>
    <dbReference type="eggNOG" id="ENOG502SHC6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266207at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="331" mass="34579" checksum="701CDB677B0FB440" modified="2014-11-26" version="1">MADDHSLSAGQEGLSSPCNVYRIKHNPSWIKFGMHPEILTDTNARLSRLTSRGALSRGASRESSAVPSANTPFLSTALARQSASSSSLAAIGARAALRHEQHQQARATSRSTDSQPPAFHASAVHRDSHSSVSVSASATPRVRGDSDTEACAPESASLERSESMCGGSATGSTPVTTAFKGKGSFCDHESEMSCFPDDTHSSVFTNSSCRAGAARVPSLQPSVFSLPTASSSRAKNSHLIGSAALVGVAGPLDNLYVPLRRPAPRGCVATRQHFSLFEGTNCKGSPGMSAIETRAAPGVHREVHISRRGLVGGAPETDTYRTTNSAYGRGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0J1</accession>
    <name>A0A088S0J1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Guanine nucleotide-binding protein subunit beta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_342970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702723.1">
        <property type="nucleotide sequence ID" value="XM_010704421.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22578802"/>
    <dbReference type="KEGG" id="lpan:LPMP_342970"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340036000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_342970"/>
    <dbReference type="eggNOG" id="ENOG502S3EJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1068471at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051242">
        <property type="entry name" value="WD-EF-hand_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44324">
        <property type="entry name" value="WD40 REPEAT DOMAIN 95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44324:SF4">
        <property type="entry name" value="WD40 REPEAT DOMAIN 95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1294"/>
            <end position="1314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1767" mass="190616" checksum="2B80570E58A3013F" modified="2014-11-26" version="1">MRAPQEGPVPRLAIVLGSEVSLVTLQQEWAAFPQGVSYAEFRQLLEPHIRPHPCFSEAINANVALLHSCTLPLCSISASSPSASPYAPGKLPQALSSAPVVPAPAAFDDTSSNRESERTRRIRTRQELAGVTTRSVDPIKHLFNRIDVHNQQRVTWEELVNYLVAEASIDAAGKRLSTTTLNRFTFSRLLRGQSKRSQEKQKIKKDTTTEAPTFKRYYRDVQGVPQTCRTRAGEDNDAIRRRAVAVVHEDEDLALIRFLDGLPGHKSLFFASTRSCSFILYSKGTLERVYSAPPEMLPGVSPSAVSYLDGCDLFLCYSSDDRLLRGWFSLLSHAVTTMTVTPLLVEGLVRRIQVMPRESPTYADYTETLFLGNSFGHVLRVVAPHRHSGGMEFKVVQTFSNLHTRESGGLVDFCLYGAHLYSCGFDGRLVATSLLTGKSSDLGRMVNEHFTTLVYVPEHDWVVAATSCGRQLLWWEAHSHGTLPGTPFDLAGHGEPVACIIALIYVAAVDHVVSADSKGVMKVWDASTQRCVQSFRGNRVPQRLGSSICTVPADEAKVPATKTRTAVHPSSGLLTGNLAGLFVNLGLLSLLPTGTGQASYVGGPQCHSLIYCESTQELLCGFVNSIVSWGLRGRDNSLVCDEEEVCYDIIYDIRTRTFLVQGATRLSVWDGLHGHRRGVVSQTALSGVLQAGVDIKAVCIDELGSRVFISLCDGDVVSYTTQDLASDASQCTSATATVWWRGNSLGSGTTGGSTAVVEQMHYSSISRTWIAITSNGALLVRSEEDDQEVLFSVTISVSPSPLSQLRVSEELGLVAVTDAQHTVYIYDMQAWMDAPVTKRLAGYGALVDLVFLGSAPALVTVHAGGVCRCWSCAPVVERFKLLSVFCHPRHPTPELCTAVTIEAERASMGMVERTRLGRAVTTRGRLPMQSPAMAPCLHMTAATTTGGNDALYATAISPLPLGTTLPKIACISRPGSAYVASRPATPRLRVSQYGSSILQQTKSSFEETSADSTVVAGDATSAFMEFSMPMRKSAADALHDIPTGEDWLGIAATPTASVEFTSAAYDGRQHHLFLGDSEGVVHTYRMCPLLQAYRLPRCTHASRPAFSLTVATESTGLDAGDGLTVPTLVWSVQVHVNQSATTEPGVEARPASAYHGSMPTTTQHGSDRCGVVCVRWFDDRGVLATSGYNHEVWFLDSSVGEKVACLSAEQLPSRRDHADRALSASWHCQGTLTQDLMVLSGVLDGQRPKAASTLPPHNTFSLPPLPRYEDLNDDSAVAFLTGVSQPHCCAHHTTGKDSAATEEGQGAVSLSPQSKEVTDISATLSNPRLTSLGFDPLRSCVGQEQATSSHLFRHSCLEATVTSRHDRPATVLKDYMQRLKTRRGSSGRPQRCSTFLSPLPRLPSSQQALAEDVLVCWGPLPHNTSLPAGNPLEEGEYPHSTGSAVLSTTCPTVSGGDMHIYITDWQKRDLMGMRKSRSIKPQAPVPPVSHNTLVNVEESKSHNTEVTGKPLLLGPAGGVSWHAVRTAAAADVAPAVTDAAVLEDGTTPSCGARSLTANVATLNRPQGDAAGRATGPSCSTLSFSVREDSVAIGHCDTVNGSFCISNATSPALALRISGSALAAPVLDADKSAAVHQQKQKPLSQLQQAHGRIRPNFATDIALQRYERLPRVPFTQSSAPGHHSRMKAPHSIKKARWTHVDGKCSSSTTNDVAVHSSFQGITERALSSVPAKTLRPPPMLAYSSEFEGVSTLEMYSSELHQCLRRLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0M3</accession>
    <name>A0A088S0M3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_322010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701885.1">
        <property type="nucleotide sequence ID" value="XM_010703583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0M3"/>
    <dbReference type="GeneID" id="22577942"/>
    <dbReference type="KEGG" id="lpan:LPMP_322010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320025700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_322010"/>
    <dbReference type="eggNOG" id="ENOG502S1JH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="263824at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="535" mass="60427" checksum="728C17B87AFCCE20" modified="2014-11-26" version="1">MAIIAQSFSDHYAELVTRVPTYTELLLHVQRREVGERKALEERCRMAFQDVLHVAAVMIADNKALARGGALARRNRFELTLYKKETSVWFEAVPPRQVALPTGRPSRAFPYAAFAELQQEERELRQWGYGVERRLREHIEEVCSRTWFFLNLLTDTMARETLSRQRLEYEEDEVFTSVKQRFFRAVPADYYRHLVITRYGPTTPAVEPVRDLGFEEIEEDARAMLMAEEEASRTSVFQYLQGVYDMQLFALNHCEVISRYELEEEERNTLFPLVAQCCREDFGILFYYVPALALHFSSSQPCMRALCLAQLQEAPRRTAAVKARFSWVPAHTLAGVDSDLDDQAARDEMDEGMEVGAEVTDDDTGGYDDSINSPSPPLERMVTAPGTSSVVFEPEIGTSEASGLETLQEKLEMATPPTAEDVVVPCADEEPTPVTVVSVTLGANDAPQHVPYAYTTEEVIMPVLYAYEKMEAQFPVTYTYEEAQAVPEDAFTAASSHESSTCILTPQPPQCAIYTNFEVFPGDPFAWSPQNGKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0U1</accession>
    <name>A0A088S0U1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_341950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702621.1">
        <property type="nucleotide sequence ID" value="XM_010704319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0U1"/>
    <dbReference type="GeneID" id="22578700"/>
    <dbReference type="KEGG" id="lpan:LPMP_341950"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340025700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_341950"/>
    <dbReference type="eggNOG" id="ENOG502SIQV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="249649at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="485" mass="52939" checksum="4A6D2FC563FE9E54" modified="2014-11-26" version="1">MTRLAVQLISAQPDDPEDFLWARLEARSFSEDVTHDVAFSAGGYPVVRPEDPTQVSLLKDIPVTSPGYVVATGLLPLLFARKPVDPIIYLFYHIGSRARSSAAQSVHSSTRHLHFDDEEENGFDVESCTSREFDDDSNFAADDTAEVGSAGGSISMIPLQRKGSLGSLFDSAASPTAQLPRRRSDRSDNVRHRLSQSAAMPRSGSTRRNTTGATRTSRDTTATQPLPKELAALSGSSSALKRVSVAQQDGKQRSPMHSHHDNSAGSAADIGSSAPRPQRIPSGSAAANTLHCIESDERARVCSEFEVLRLREELRLERLQHEVRTLTRECEYRKQVALLNRTDRMADRAAAMAQEALEEAHKYRAFLCAQIDQLEVEQQRQLRLVSQHLGQPSPSLSAAGVSQLPSPISGYRLGAEAPLRYAESQVPSELDILKKQVELLTMEQVRARSMGYGVTPGYAAAAPHTTWLPISVAGATESARASYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0Z0</accession>
    <name>A0A088S0Z0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleoside triphosphate hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_342600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702686.1">
        <property type="nucleotide sequence ID" value="XM_010704384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0Z0"/>
    <dbReference type="GeneID" id="22578765"/>
    <dbReference type="KEGG" id="lpan:LPMP_342600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340032100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_342600"/>
    <dbReference type="eggNOG" id="ENOG502QTV1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="391988at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01876">
        <property type="entry name" value="YihA_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030393">
        <property type="entry name" value="G_ENGB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11649:SF72">
        <property type="entry name" value="G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11649">
        <property type="entry name" value="MSS1/TRME-RELATED GTP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="5">
        <location>
            <begin position="110"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO01886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="647" mass="72217" checksum="94B0C48AB988A12D" modified="2014-11-26" version="1">MYSCSLLRLCSASLTNSVATHSPGSRYTHKPIEAARQQLKHRQRERTLQRRRNIANKEAEVQRSVKEVTSSRDLILVQLADQIFSKGHRHVASATNVGFVPDGNPATPLVALAGRERCGKTSLLRALFRSPREVGRSNRHLRRDAMNFFNVGGVFNVVDLPGFGGTSVPWTAVLQHAVLLRNFSRCQPSLKMLYYCMDVHYKHGLYIQDIDLVRFLAREVPNFTIVLTKADQINDRAIRTAHMEEVRKELLYHDIHHPVLVTSAFHMGGIDTLRYDMVMNSVHALRTERLTLTEAQRLSARLFSQRELSTIRPLAIAPSQVDDETRDWNAELQLTERGEEGVLDMSSVDAAMDAAKDAGSVVDATEEELRYSETEFAGFAATEDGAGSTAATAAASSSTEEVLLAENVPLSEEAAVRAGAALDASSSSTHIPVVFKDPVMQMAYERVVKTLRNRPLLQYVDATSPWRNPLRWPRHVIPTKHPKANIMRCPEAPENPYLLQAQYVAPRADMYFRRPNIGARKSSQKGKYEPDKPLAFILKAYTIPYFPDIVDTAMQPAPWAFLGSREAYYERNGGRQLGVRLANYATAGSMNPLSDNPAPQKLELTKELQALEEKRYGGPIAMLRPPEGKLALSGARSHVSRLLEPNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S166</accession>
    <name>A0A088S166_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase GlcNAc-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_020160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009371">
        <property type="protein sequence ID" value="AIN95196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698161.1">
        <property type="nucleotide sequence ID" value="XM_010699859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S166"/>
    <dbReference type="GeneID" id="22571826"/>
    <dbReference type="KEGG" id="lpan:LPMP_020160"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000006700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_020160"/>
    <dbReference type="eggNOG" id="ENOG502QUWK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="76265at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021067">
        <property type="entry name" value="Glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34496:SF10">
        <property type="entry name" value="GLCNAC TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34496">
        <property type="entry name" value="GLCNAC TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11397">
        <property type="entry name" value="GlcNAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="863" mass="95690" checksum="89FCF70E5958FC7C" modified="2014-11-26" version="1">MLRLLGFVNDDDDPADVSQTLVCACTAVGALLVLLLINFAALVVVLVVMVPAAQRQLPQTAQSLLDFNHKNKGGTADGAALASGLDIRRLLAGGGLETFLREAHRVEELRRRVQGNATLLAALRKANEARNNDGGRGVDLVRLAQTLPELEYLSFLLYQVSAHVQAVQERDPVMGLVELSDFLLNAKGRREALEKAAERARAEEVNVTTAATVGGGARATGGGSVEKWNAALKESFAGRSEAARLRAQLRGFIGVASSEAERLTQQPFDDLALLQYRHAWMQSEVLPIMRSRSRRAGAQAVKEGPHAAVLRSNTASRPPENTSVRTSVEELRVYGVANRMAMKAVLYEVASIFNHIYYYPLRRYEALRPYGGDSVADTDAWYSAITAAVQTRFGVPIACNKAQTTEAAALPLVLRDSPLSVLALSRLGFRRAEEVAHLYSQEDRQLMPQALNPKAAVNVRSIFVSFASYRDAECASTLLDLFRAARNPHRLYVGIAQQNRAGDSPCLLPEMYTPYLCPSEGLQGAAADGGVGAARESRARARALYGEGADLTKPPNGPEARHFDERVCFLAEQVRVREIDSGQAKGPTYGRYMAMLLYRGEGLALVLDSHNRFRPMWDALGATMLLRLEDAKAVLSHYPESYPGEKADLLPYRRTTAYLCRAHFLKPFGYLRLNGIVIGSTAEFAKNNVFNDPYVRVKSREIDPTTNYRLPQPWVAGGFLMAFGTIFRDVPFDPHLSYIFDGEEVLYSMRLWTHGYNLYSPPRGVCFHIYGRQEAPKVWSESALWYNLQNRVRSRIQFYVQAHLLHAEKVLVPANSTNPFVVMDSSRYGMGKQRTVAQWYDYAGIDPVKHQVDGRWCGEDVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1A7</accession>
    <name>A0A088S1A7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_350020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702943.1">
        <property type="nucleotide sequence ID" value="XM_010704641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1A7"/>
    <dbReference type="GeneID" id="22579031"/>
    <dbReference type="KEGG" id="lpan:LPMP_350020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350005600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_350020"/>
    <dbReference type="eggNOG" id="ENOG502S60C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="238779at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO02143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="152" mass="16676" checksum="2A82BF73C9E289EF" modified="2014-11-26" version="1">MGCNNSKLKTPGVATGSKGADEFYVLATTKGHPVAQKLLEEWVLFVDAQVRRNAGDSSAAQAYETRLKEVWADTGSCPVTHRSVDYVGKTFLEYIKQDLSHRGWGGNFDYKVAGVVTQGFLKTTANIDTAISETPEEVQWEIKIHYDSSGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1L7</accession>
    <name>A0A088S1L7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Inositol phosphorylceramide synthase, putative</fullName>
            <ecNumber evidence="13">2.7.8.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_344820</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingomyelin synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.27" evidence="13"/>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702901.1">
        <property type="nucleotide sequence ID" value="XM_010704599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1L7"/>
    <dbReference type="GeneID" id="22578987"/>
    <dbReference type="KEGG" id="lpan:LPMP_344820"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340056100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_344820"/>
    <dbReference type="eggNOG" id="KOG3058">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="422827at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047493">
        <property type="term" value="F:ceramide cholinephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033188">
        <property type="term" value="F:sphingomyelin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045221">
        <property type="entry name" value="Sphingomyelin_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025749">
        <property type="entry name" value="Sphingomyelin_synth-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21290:SF25">
        <property type="entry name" value="SPHINGOMYELIN SYNTHASE-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21290">
        <property type="entry name" value="SPHINGOMYELIN SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14360">
        <property type="entry name" value="PAP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="3 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingomyelin synthase-like" evidence="12">
        <location>
            <begin position="211"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="330"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="343"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="357"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIO02101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="385" mass="43285" checksum="BA7F311F6EA069C3" modified="2014-11-26" version="1">MPSHEKVHVPGRKEDDETSSMPWYKQPLPLTTQVMRFALLLPLTALFLGVAIVITNGRMPDPKRMPPLPDLLLEWIPKVEFVEIGTDIIILLLNATMVVVGFKVYLLERHEQGMPNLTFLERIPRIGTSVNRVVFGILDSGRRPYPLKGVLQIMVVRFLTSYSVVVLFRALVIVATSYPATDNHCQHPQAIEDPVVNVILTLVTLGSASIHCGDLMFSGHTMILCLAFMLIWDYSPFLYPWAMRVWASVLLPASFYCILASRSHYTDDILVAMYVMIATYKLISHAETGAPWQLQLLIRWLPWPGTNTTEERWPTDEVVVVVHMPAQDESAASSPMPEYEGVTKTTVPVQSVTARSSGRDTHLLRMKDSSESNGLHPDVCETLQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2J8</accession>
    <name>A0A088S2J8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_061020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703983.1">
        <property type="nucleotide sequence ID" value="XM_010705681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2J8"/>
    <dbReference type="GeneID" id="22572308"/>
    <dbReference type="KEGG" id="lpan:LPMP_061020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060016400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_061020"/>
    <dbReference type="eggNOG" id="ENOG502S7F6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273674at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051876">
        <property type="entry name" value="ODA-DC/CCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21694">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21694:SF18">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="305"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="494"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="95"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="500"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="718" mass="79742" checksum="97652E59A9298C38" modified="2014-11-26" version="1">MPETQVRRRLTQVEMRLRDIDEEARRISVLQEQEVSKLENDNAKLRERLEAIRMEECMSLAEVQALKDYASYERTSGAPAGRSESKLIGSTTLKYQNAKAEVQKRRRECAQAERQLAESQARLADVRKARKELKRQNFTAEVSAAARSAAADNYRALIHERFRGLEERVAREQERLNAAIKEAQEVRTEIDTLLVSQTSNDTMCHRQCDALLAKRREMAYLMEVCNLVCEERQCVVAELTEMQARMAEESHQYEAVFDELTGVQNENAKAQAANNDQLEELRRIIMQTRVEREGLEEDNNNVKAAIERQHRRTTTRRLNDETRAAAASESNLSSSAFAEERGIAAADGVAPAGRDGGAELQTPESELSLDSNQAQVRLFEDYYRRLSAIVQSDAIEDVVGFMDTAADERYKVFEEVNAIKRNMVALEKEKAALMMPISGGAGDRVTASYLTTRSPGSSASVSESVGHPFTSTSALAALAVADTLEDLTTATASMAAEKSGGSSVPGTSTEGRQERSSRMFDLLDNFGAMRDRVYEQEKEEEESAAVLAQVVEQVNEVFRGLGCSIDELRTLTGLEGVQQGTLLQCLAMVEERASEYLIAYSRQQQQQLLLPFSEASHPWPGVPANAAAVVSATCPEHTAAHTLLRRLDLRPRAKKNAVAATVMHHALPRSTDVTTVMPNINARPTGSSTTFENLVEDRPLSEVELREVVEAKRALLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2W8</accession>
    <name>A0A088S2W8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_342990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702725.1">
        <property type="nucleotide sequence ID" value="XM_010704423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2W8"/>
    <dbReference type="GeneID" id="22578804"/>
    <dbReference type="KEGG" id="lpan:LPMP_342990"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340036200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_342990"/>
    <dbReference type="eggNOG" id="ENOG502S169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2573163at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000828">
        <property type="term" value="F:inositol hexakisphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF21">
        <property type="entry name" value="KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO01925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="376" mass="42237" checksum="B7846F1ED639CA11" modified="2014-11-26" version="1">MSGESSPRQFEAVGGHKSSIFYGKPTRDGRSTLQKTTTAWEIMYYLAMELAKEDAFKQHPITAHPHVDEARAKFIYAAGKLAVFTSTLFSIHFPEKYITKSAALKPYIGRANEWILMEAGAPARGAVLAPLFNELFDGAEQLKGFNEEYDTGIWGIGLVDETSGMQRPCIMDVKLGFIRHSPLTPEEKVARMMKKEHNSLVRSTALRICGCRRYIHDTSNNEGAAATLICERFGKDIGYAISDVRVLSTCLTAFMSIGEPLAERKENEQLDFHPEVMGAITSAEQVHMKQRIRHIRAEIKSLLHFFEGTPDGNFMLQHMAFVSASVLLLYDAADSSARAKLRFIDFARSTWRKFNFDEPTIGFIQGLKNLDAYLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2Z7</accession>
    <name>A0A088S2Z7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isochorismatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_080320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="AIN95841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704163.1">
        <property type="nucleotide sequence ID" value="XM_010705861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2Z7"/>
    <dbReference type="GeneID" id="22572494"/>
    <dbReference type="KEGG" id="lpan:LPMP_080320"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_080008000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_080320"/>
    <dbReference type="eggNOG" id="KOG4044">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269496at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050993">
        <property type="entry name" value="Isochorismatase_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119">
        <property type="entry name" value="HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119:SF3">
        <property type="entry name" value="ISOCHORISMATASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="148"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="245"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN95841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="294" mass="31849" checksum="E671019937DC3692" modified="2014-11-26" version="1">MQDTHTHTHFCGNAESQTPLPPSLPPSSSSLFRMSELAEYSRLIQKFDTCRTAFMMCRGQEDVEPHTRDFHNAFQVAKAMAAVHQLLGPEWSVFVATGPYSSQDTRHADHDVQLPEDAIIAENVQTSMLVPEVQLYILGDAERGISPVQQVIIWGCETYGCVLQTSDELLAHGIRVAVLVDGCTSRIAEMHDTAILQMSHWDGLMVTTAPSAIVQLTRSDARFVKPIIQILKTFAADWSTTQPLPELSSQRMGGGDGDPATAVSDATAASPVSAVTTAGDAATKRNSAYSGKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S324</accession>
    <name>A0A088S324_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_080620</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="AIN95871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704193.1">
        <property type="nucleotide sequence ID" value="XM_010705891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S324"/>
    <dbReference type="GeneID" id="22572524"/>
    <dbReference type="KEGG" id="lpan:LPMP_080620"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_080011800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_080620"/>
    <dbReference type="eggNOG" id="ENOG502SQTK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267729at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839215" description="Transmembrane protein" evidence="3">
        <location>
            <begin position="30"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN95871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="142" mass="16111" checksum="8D7786C503E02565" modified="2014-11-26" version="1">MEGARQCGATRLPKRLLAALFAVTVLLEALDDTLPVAQAVVETPAPTPYVRRTYEAKVSFFTKYWWVGFIMMFVAFLLVVGALYVAVQFHFKESEQRDRRKELEMNRFSIVNCRGGEEVGGHEADQQGRSGQSLRNNPLRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3A0</accession>
    <name>A0A088S3A0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_090500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN95966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704288.1">
        <property type="nucleotide sequence ID" value="XM_010705986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3A0"/>
    <dbReference type="GeneID" id="22572620"/>
    <dbReference type="KEGG" id="lpan:LPMP_090500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090010200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_090500"/>
    <dbReference type="eggNOG" id="ENOG502S2WT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272512at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063:SF52">
        <property type="entry name" value="LYSOPHOSPHATIDYLCHOLINE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063">
        <property type="entry name" value="PHOSPHOLIPID ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN95966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="44054" checksum="316AE1BAE00577B3" modified="2014-11-26" version="1">MEKFRHFGDAATGIHPFTFVIAPTSAGRIASICMFPIRLLLSTVFVLLLLVTDTLLWVFHAAYLGLLGRLLLAPLQRAWLRGLLFFIGHILPEQPAVLVKPQQQNGEASSSSRAVRAGDLVVCNLQSVWDALVLEVVLAQPYHAICFPDATTTAEAGATPGLRVFWPSPMQRWKVWAYTRRTGSLVFLTAQQPGNADQQAIQKKTETTELPLYRVQKAAARAGVPVWWFGEGTCSNGRGLLLMPTVTCMSAAPHKASAECVVHLATIQYDSPALQNVLGDDSEGFFEALFRTGVLLYGSTTSAWASPFLTSAEVTYRSARLARATPSMAAESKSTASVCYWTLSTPVLLELRNVMCQRGQTLLVSGSCGGMRRQPLSVGMNEKKGFIEAYRAMLYSEKMRSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S469</accession>
    <name>A0A088S469_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA pseudouridine(55) synthase</fullName>
            <ecNumber evidence="2">5.4.99.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_110550</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase Pus10 family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="2"/>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696904.1">
        <property type="nucleotide sequence ID" value="XM_010698602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S469"/>
    <dbReference type="GeneID" id="22572920"/>
    <dbReference type="KEGG" id="lpan:LPMP_110550"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_110009500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_110550"/>
    <dbReference type="eggNOG" id="KOG2364">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271937at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160148">
        <property type="term" value="F:tRNA pseudouridine(55) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3190:FF:000001">
        <property type="entry name" value="tRNA pseudouridine synthase Pus10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039894">
        <property type="entry name" value="Pus10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048741">
        <property type="entry name" value="Pus10-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21568">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE PUS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21568:SF0">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE PUS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21238">
        <property type="entry name" value="Pus10_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pus10-like C-terminal" evidence="5">
        <location>
            <begin position="422"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Pus10-like C-terminal" evidence="5">
        <location>
            <begin position="518"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN96251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="721" mass="78883" checksum="377EE2832BA3885F" modified="2014-11-26" version="1">MSAVAAVAAAPGSTTWPKDALCYQCALRMSMLFDYPPPRTMGQLQPSLASEPVSALSDDTLPTLDDAHHPLFTLVHETPKSVRRYFCGALQPIVTTAGDLKAPLPTGTPKVNGPTAAESTAHGMLGGDSAPPYAVTWLCVACMGLYQFIDLIHAPLAAAAVRTSPFYDSEAITINVNINRSFTFTWLAVAIRYFDLNGTGTERPLPSSIVKEELNNFKDFYMSDLRARILPYLLDSHDSVAASSVLPAASSRTAQLPGLAVYVEAVGALLDSTREAGRRGAAGGEAVVKRARTEETAAFSEPVSSSRAAAPGCGATRPALVALQAFRYSGASESLVSDVFCRHHATEGLITEGHMPAAYCGNRSTEVLPYSVIYDYVVPYLTKAGWMPGTATAAAEGRQEDCRATARQAATVSFQVHHKNIYLMGRYRKMMRNMSQSPWFLHGQRIGSFSLQEVIANPVLPFFFPDMPAVPPEAPASPVLLTSEEGKLASAASVMVERGTHATRWQSVAPPVASSALVFGYKRYKFHSAGREDVDVRMLGEGRPFVLELISPIRERFTEDDLRCLEALISASYEGSIEVSQLRHTNADITVRLARHSESKVKQYRCVIWSSRAINDAAADPHVRAIHAMKDLSIQQKTPLRVLHRRSLHWRPRLIHSMRLTPLNPHWFLLDLETQAGTYVKEFVHGDMGRTTPHLGMLLNARTDIIQLDVVGMAMHDLDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S4E0</accession>
    <name>A0A088S4E0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_120130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009381">
        <property type="protein sequence ID" value="AIN96341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696994.1">
        <property type="nucleotide sequence ID" value="XM_010698692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S4E0"/>
    <dbReference type="GeneID" id="22573019"/>
    <dbReference type="KEGG" id="lpan:LPMP_120130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_120006100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_120130"/>
    <dbReference type="eggNOG" id="ENOG502SCDI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267838at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="251"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="713"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="789"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="34"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="371"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="536"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="714"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="812" mass="91711" checksum="819337EFBDA940DA" modified="2014-11-26" version="1">MCSKAIKRLLEEAEMAVHRCRLLEGMLNEQAMQGEKLRTDLHEQQEENKLLTHEKESLKATIVRMEIEAEVAAAAAAARTVNPVTPGHTPASTPSKANAEVHVNASASAESVAAVEEMLSKKKRQLDVREATLKDALKKVSADAAKVADQRAALQEQEKRMTAQLTAQLTSLFEEERQRLEDICADAVTDMQNTYREWIAQQRDAAVERRRKYEHVMETRLQRATSEVAEMRAERDVLQQTLENQRAQLAELQNASRVQTERRSEAKDGGPSSQYAREEKESLQEAVAESIPRAGAANERPHATQTDPDITELLGGGEQLKHANAAAAYAALQRRAQDSIAALMPDMRAKEVEWERAKAAAVATAESAARLAERERLGQEAEKTRQESQREIKEAMRIVAQQRDSAMDVLRTQHQRDKEEWLSKMRRLEEGQQNQEEAWRAEKAAFQKKCSELETHLEGRKAAAGKLQQQLRDAKRELSELKAKARDNEDAVAEERRKRANATAKTVQYSASSLLKEAQQGQQRILAAHAGALALLQEKMQKLAQVNSAAANSREERRREVTQRLHTELECTRQERDTALEQLGKMQEAAEGMKARMNEESAQLGALRDVIQRQQRALARLQEQHQRTVDELRAARAAVSAPSAADAAASLAESENPVVRATDDTCYRVLLRLEQRWVLQQADLQCCYSVALYAVVQRTWTQMIGRMTSSLVAEAERQRRSRDRSAEALENTTSTIKEVQRDLRLRMQALLQQQVDVEEREKRLQDKKKRMDVVCRSLHTVAQELRKKHLDATENPTLEEVMKSARVMSESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S4X5</accession>
    <name>A0A088S4X5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_131290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697209.1">
        <property type="nucleotide sequence ID" value="XM_010698907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S4X5"/>
    <dbReference type="GeneID" id="22573239"/>
    <dbReference type="KEGG" id="lpan:LPMP_131290"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130017600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_131290"/>
    <dbReference type="eggNOG" id="ENOG502SBVA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="263223at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN96556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="246" mass="26860" checksum="34B6D1757D7109D9" modified="2014-11-26" version="1">MSSALIANILAKVEVEVRQRLRSTAASTTPGPSPAAAPLTSLSLLTSEDWSAVRCSLRADSTLPPSAAGATNKVEGTSASLQPVVASELLRYVQMRCAELPMRLQIEALQARRYEHLLRQHTRELVTLSEYMALVSRTPPTLAAVPRGVSEPTPNVAQLPVDVRALLAEEEMGPRLERCRVRIRELETMARQDAEAKVRCCQRMVLLSEFVRALVRHVTADVLTCKGAPKCDGAAVTKRPRTEQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S6K9</accession>
    <name>A0A088S6K9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UTP-monosaccharide-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.64</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">USP</name>
        <name evidence="8" type="ORF">LPMP_171130</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a monosaccharide 1-phosphate + UTP + H(+) = a UDP-monosaccharide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13205"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:140358"/>
            <dbReference type="ChEBI" id="CHEBI:140359"/>
            <dbReference type="EC" id="2.7.7.64"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the USP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.64" evidence="6"/>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697804.1">
        <property type="nucleotide sequence ID" value="XM_010699502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S6K9"/>
    <dbReference type="GeneID" id="22573856"/>
    <dbReference type="KEGG" id="lpan:LPMP_171130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170017600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_171130"/>
    <dbReference type="eggNOG" id="KOG2388">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="532420at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051748">
        <property type="term" value="F:UTP-monosaccharide-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039741">
        <property type="entry name" value="UDP-sugar_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952">
        <property type="entry name" value="UDP- GLUCOSE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952:SF9">
        <property type="entry name" value="UDP-SUGAR PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN97151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="630" mass="68550" checksum="8F57DF22CAF2D396" modified="2014-11-26" version="1">MSNPSNSHLQALREELCAPGLDQGHLFEGWPDTMDECSERQIALLMDLYLFSNVYHGGITQYIRNGQALLARESGEVDFAALEMPPLIFEAPSLHCRTAEMTALENAGTAMLRKTVFVLVAGGLGERLGYSSIKVGLPVETATNTTYLAYYLQWAQQVGGKEVPFAIMTSDDTHDRTLQLLCELNLEMPNLQVLKQGQVFCFADSAAHLALDDEGKLLRKPHGHGDVHSLIYNTTVKGLAVSDSSDGTEPAQSLVNAWLAAGYESIVFIQDTNVGATVTIPISLALSAEHSLDMNFTCIPRVPTESIGLLCRIKKNNGDPWLVANVEYNVFAEVSRTPSNDGGDEVGRPTDFSPFPGSINTLVLKLSSYADRLRESHGTVPEFINPKYSDETRHSFRNPARIESLMQDIALLFSEDDYRVGGTIFERFSYQPVKNSLESAALLVAQGNRPYCAATGEADFYELQRRRLKAIGLPLFYSSEAEVTVANGAVGVRLFPIIVLDAMCASSGSLDDLTTVFPAPEKVHIDQRSTLVVEGRVIVEDLELCGALVIRGPRGPAEPPYVVRNAVVRNAGWSVHAVTSFCSGRDGNVSEVDDIRGFVLEKTAMTVMDYATHSGSAADAPFGATDSAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S7M3</accession>
    <name>A0A088S7M3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amastin-like surface protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_200990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698298.1">
        <property type="nucleotide sequence ID" value="XM_010699996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S7M3"/>
    <dbReference type="GeneID" id="22574306"/>
    <dbReference type="KEGG" id="lpan:LPMP_200990"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000052800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_200990"/>
    <dbReference type="eggNOG" id="ENOG502SPBK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009944">
        <property type="entry name" value="Amastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297:SF4">
        <property type="entry name" value="AMASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297">
        <property type="entry name" value="AMASTIN-LIKE SURFACE PROTEIN-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07344">
        <property type="entry name" value="Amastin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="195" mass="22389" checksum="61367626E9DCE102" modified="2014-11-26" version="1">MEWNLALLLYLVLQFFAFFFVLVATPLDVFRFKDIRNFTRNMCATLWGFQLNCTSTKYDNSNDGLWRNCTSRRDRFRALQAFALISIFVYGLAFVLGVIQLFCCRWLRLVCLALNIVGVVTVFIIWIGIVVTFYKRDGQRCPGMNTVSTYGAGFVLFLLAWILDIANIVILLLLSLYENSSETVSTVERKSQPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S853</accession>
    <name>A0A088S853_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_202650</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698468.1">
        <property type="nucleotide sequence ID" value="XM_010700166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S853"/>
    <dbReference type="GeneID" id="22574475"/>
    <dbReference type="KEGG" id="lpan:LPMP_202650"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200032300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_202650"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="444540at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051581">
        <property type="entry name" value="Ca-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34524">
        <property type="entry name" value="CALCYPHOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34524:SF6">
        <property type="entry name" value="CALCYPHOSINE LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="67"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN97761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="422" mass="47146" checksum="A7A30A1E70AE4B32" modified="2014-11-26" version="1">MNCDPQNALLLEQTAQKTKRLLFLRSPSGVNGIRSFSRSLGIADDLGGTQVSAGELRRALQDNSVSLEEHEIQNIFTVLDRNGKGSIDPTEFIAVMCNNLSPLRKVWLQRVWRAFIKDPEDGSVEVRELQRQFIAETHPAVLRHELTAAEVRKDFASTFSEITNPEGKVSAQEFWEYYAGVSVSCNDDDSFVALLRGVWPLPGVSHDLSTSLAKDKAQYQVSYHTEQSLAEKTAVAHRKETLSALMTMIRCDHAPVILSSGAAARSLCLSLAKADESCGGFVREAAFLGALRQHRLYVPNPSLLECLDTNGDGSVDIRYYEALLLPSPSAARLMLLARLWSRCFENKDTAYSVPVQELHRKYHPSSPADKDAFLTAWDVRTAMGGKVQLEELVQWYVPQSAAVQRDKDFEELLHRQWGMYDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SAN0</accession>
    <name>A0A088SAN0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_240470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699388.1">
        <property type="nucleotide sequence ID" value="XM_010701086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SAN0"/>
    <dbReference type="GeneID" id="22575456"/>
    <dbReference type="KEGG" id="lpan:LPMP_240470"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240010600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_240470"/>
    <dbReference type="eggNOG" id="ENOG502S94U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265010at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="237" mass="25894" checksum="F0BFC55A3AED1473" modified="2014-11-26" version="1">MDKAKTLEVLRGMKFMQRKEEAKRRAAFEVAQREEIERQLLNPGTDSSGVSRGTSDGGPSVLRHSRGDGPARATVLYDDSFPAHAYGLSRRSFTETLAGGGAALITENLGDTGANLVEGAIESEILLRNVGEAPTLADAALDHSDVSSDEVEDLWGGEDAKGGVSDPTAIPDRRLQGGERTRTRRGDGDPHARSDGRFVVKSSVRAPKLPRRLQESVEEHKRQRKRNRTEAEDDVYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SEN8</accession>
    <name>A0A088SEN8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MATH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_300060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701042.1">
        <property type="nucleotide sequence ID" value="XM_010702740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SEN8"/>
    <dbReference type="GeneID" id="22577060"/>
    <dbReference type="KEGG" id="lpan:LPMP_300060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300005600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_300060"/>
    <dbReference type="eggNOG" id="KOG1863">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="CDD" id="cd00121">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000018">
        <property type="entry name" value="MATH_domain_containing_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050804">
        <property type="entry name" value="MCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46236:SF35">
        <property type="entry name" value="MATH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46236">
        <property type="entry name" value="TRAF-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="3">
        <location>
            <begin position="418"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="623"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="725"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="177"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="729"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO00242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="761" mass="86708" checksum="91E13CF5C3E9DF84" modified="2014-11-26" version="1">MHRLSSLSEGDLCFYQSTLYQLIQDAPVEAKPGREMLRTLRKELIRSMEQKEFPEYCAALADLYKTVADTLISAAHRSAPHELINRTTSDCRVVTDEDEYQFHQEEGFFDDDDDEMDSSSDLKSTAKDAEQKQRKREETKRKRREEEDMLMKERKVTDEKGKQYHTLGPFPPPRLTVRTSTNTFPSRKALQQRTIIETPSSTSSSSDEDEAVSQLISSRSTEGGEAVNHLTDFLQPLSIDSLKKVGESAKAKLRPSSTHDEFVSQIVKTAVRLGCEKACVLMEKQKIIEDMTSHVQTGPLPTAASIDFLNTLPDHLKQSLGSVLGLPEEKPPVEDMWERMVAMGFLSVLTNLRLKPLKKIANELSIVLPDTNSTEKFCEFIVFAAFPRERIRAKFSRAKQKKVRFTVPPDSMSIKGDMGFVTFHVNNISMLTKESERHYSPEFHFANLKWSLLCMTNKESLALYLCQTGSVHCKFLITVVNKANSDDSICNEGTQSFSAMSQENDWGFNNVIKFAELLNPDQGFVTADDDSITIEVGIVLVEPLKTPTSREKAPVPKEKKNEPRVDEAAMLQLLADEKVEQTRKKLKQEISKTIREEEKTRKDITQRATKAYHDLCDRLRQETKRTQKEVADRERKEEQERQRELDKIKYAQEQAAELKSRLQSLKKENAELAQSKQDTTQAAKEAKMASERIAQELKFVLDRVQSTQQKLKAQEMKLAAAKSRYESVLAEEPDTPSPSDDENDLMSEDLTRFISLMTDDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SEP4</accession>
    <name>A0A088SEP4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Leucine-rich repeat protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_300160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701052.1">
        <property type="nucleotide sequence ID" value="XM_010702750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SEP4"/>
    <dbReference type="GeneID" id="22577070"/>
    <dbReference type="KEGG" id="lpan:LPMP_300160"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300006700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_300160"/>
    <dbReference type="eggNOG" id="KOG4308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="262416at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO00252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="359" mass="38722" checksum="FFA187988EA38DF9" modified="2014-11-26" version="1">MPTFSSQEPVVELTYGQLTSEALEAAIVDPAGVTSLDLSGSNMSPEYCMEVVRRYISRMANLESLDLKDNKIGPKGAVCLFDALREHCLHLTYLDVNENAIQDEALYSLALLLQSVKLRTLSVVTNHITPRGLPTLCDGAVVCRTLTELSLAFNLLGDEGARIVAEMLGSHPNLTSLDLSDNHIGDLGAVAIAEAFILSSSSRIESLNLSVNHVGDVGFQAIAEALTKTNNRHFTALDLACNDAVTDVGRDALVRAVPNMRHVYSLDLTSCDLSDDNVKALTEAIRSSRTSVGSVEWYNNPRIQLVTEKALYDAIEAKAAAANARCSLNSDSSVTLYACVALTAAMVVASFIMRRRQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SJ65</accession>
    <name>A0A088SJ65_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450 reductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_342410</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702667.1">
        <property type="nucleotide sequence ID" value="XM_010704365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SJ65"/>
    <dbReference type="GeneID" id="22578746"/>
    <dbReference type="KEGG" id="lpan:LPMP_342410"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340030100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_342410"/>
    <dbReference type="eggNOG" id="KOG1158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000001">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF125">
        <property type="entry name" value="P450 REDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="8">
        <location>
            <begin position="79"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="9">
        <location>
            <begin position="394"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIO01867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="832" mass="91326" checksum="FFA4E17C06E480E2" modified="2014-11-26" version="1">MVQKRYLALVGLLVLGATSSVLLRRQRKVQRERREFAERYVKQIKAAREAHAQCLNGGSASQDSGDISDADLDDESATVKVIYGSESGNAEALAKGFVMTLRDRGVQAALIDPSRWSYMEDYLYHNKRNVPLFHPIKVTSPNSHTAKKKLCKTPEKAKESSPPLVYIFIVATAGEGDPTGNFMALFHEMQAAVRRATTDKVSTQSSDAAAPAAPFSATAEAPFKHVYYAVFGLGDSSYKYYCRSATDTNTLLKKGGGISVHRVGFGDARNGMQEDVFDEWQEKVMLALEEKCGLEMTTGTRAPPKPELQFRFLSSAAATTAATTSTTPQACPCGATAATAAPSAPVVTDNAASNHRALSSTAIPSSSVEAESTSAPPLSLPFPPPPMLLEPSLMNPTRIRLVTKTQLTQPRDSDGSSVYCFCFEAEGTGISYQAGDHLGIFPTSPPEMVARYAKALSIPADELETSVELCETVPSRGILRNVLPACVPLRVVLQRYVDLCGRPKKSTLRVLAKYCTDLVQKEAFLDLLRLPAEKEVEETGARTSSALKPKKLRTVVDYLEKFPSCCCIPLGHFIEIMPRTQPRYYSIASDRMSHGTKVEIIVRVLTDGLASSYLAHRVEEGEEVFAYVRISAFHLPQRIGENRPILMIGPGTGAAAMVGLCYKKEALMRKQPAAQYGPTVFLFGAQYRQTEYFVEEELQRWTMAPAEMRQWDIDHPTSHAGLAARRSKTHSTEPLSNSVITMVDCAFSRDQEEKIYVTSLIDKHKDLLYGMLTSTSGGGCLVFLSGDASCMAKDVDRALAALLQDRGGMTRMAAIEYLRRMESDHRYLKDVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SJ75</accession>
    <name>A0A088SJ75_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_342510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702677.1">
        <property type="nucleotide sequence ID" value="XM_010704375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SJ75"/>
    <dbReference type="GeneID" id="22578756"/>
    <dbReference type="KEGG" id="lpan:LPMP_342510"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340031100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_342510"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="86"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="119"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO01877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="173" mass="18421" checksum="7A49DEB1DBAFD3CD" modified="2014-11-26" version="1">MSDTGSSPDSTTRWVPPAETIYDACRRGNAERFMGYVEKGGCLSECDDQKLTLLHHAAFSGNMAFVKAILDRSGTQQVMIDAADREGWTPLHYAADRGHTQVAAALLDEGASVNARDTAKRTPMHLAALSGRADVVAMLLRNGASKTAKNVAGMTPVDCAKEADQAAVIAQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SKD7</accession>
    <name>A0A088SKD7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ran GDP binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_351450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703082.1">
        <property type="nucleotide sequence ID" value="XM_010704780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SKD7"/>
    <dbReference type="GeneID" id="22579174"/>
    <dbReference type="KEGG" id="lpan:LPMP_351450"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350020300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_351450"/>
    <dbReference type="eggNOG" id="KOG4198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="448399at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23111:SF100">
        <property type="entry name" value="RANBP2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23111">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839465" evidence="5">
        <location>
            <begin position="28"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="68"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="277"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="308"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="391"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="517"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO02282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="561" mass="62082" checksum="C38924806853C3C5" modified="2014-11-26" version="1">MRSVLSTMKRWLLLATPLSSPLSPSRGGGLAASWSSSHFFQGFGAVCALTNSTRAYTTLTRLLRQSWKSRNLRPWMCAKESCRVVNAETRKECESCGAEKPQLLGWKCVGCTTINYAGVRKCRKCEEASDKSKGFWMCAVCHENNRVDEIEDNSRCGFCGYNMAPHSVAEDEILRRAQEKAVMQQQQQEHYDSISYKDADEQFTNPLEGAGALDPSLRATHSGREAPIPGRVLKLPAVGPFVPGDVPETRHSRLHQRRKVNPALQTVLDGANLPEGPPGFDWMCRNSSCGQINPGDEESCLKCGTHITPAEWECPLCAALNHLARSRCFHCRSRIPVCWTCRACQGTTSIYDKVCRGCGIDRPAAEPRTVREVERNGGGHAGGYVPQGNRARGEWYCSTCSSLNYSRRTECFQCSSPRPSSPAQAVTDSFSATGWGEMDGTGTAAIATAVQHNNWICVYCQTSNFRTRRDCWKCGRATERADEWSSKGLTPQYEHEGFQEGSGARSAEGNMNTSWRTSGDWMCAKCYSKNFRSRLECFRCGARKLAVSASRGCGARKPVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SKH6</accession>
    <name>A0A088SKH6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable eukaryotic initiation factor 4A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP-dependent RNA helicase eIF4A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LPMP_351900</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family. eIF4A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703127.1">
        <property type="nucleotide sequence ID" value="XM_010704825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SKH6"/>
    <dbReference type="GeneID" id="22579219"/>
    <dbReference type="KEGG" id="lpan:LPMP_351900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350025000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_351900"/>
    <dbReference type="eggNOG" id="KOG0330">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000892">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003135">
        <property type="entry name" value="Putative DEAD box RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF24">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 13 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="84"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="281"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="449"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="12">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="449"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="471"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="494"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="513"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AIO02327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="527" mass="59296" checksum="0D47557200F0FA26" modified="2014-11-26" version="1">MPSARRKLTEAIREDEGGDDGESRVSMVARNTSSAKHQSLGSDLLDNEEFKTKTFKDLGLCRELCMACAEAGWQHPTRIQASTITVVAEGRDLIGVAQTGSGKTGAYALPLVNWLLTQPKTPYLSVLVMVPTRELAQQVTAQFLLLGRSVGLRVATLVGGADMVEQACELSKRPHVIVGTPGRVKDHLSNTKGFKLVKLHALVLDEADKMLDMDYEKEIDAILEQLPQDRRTMLFSATLSTKVDRLQKASLRDPVLLQVHRKNTTVDTLKQYYIFAPFAQMLSYLHLFLTKETGNHILIFCRSAALVHKITLALRTLGHRALPLMGRMDQSNRNIALTKFKEGKVRMLICTDVAQRGLDIPHTDVVVNFSLPDHVEDYIHRVGRTARAGAEGKAVNLISQYDIVLLQKIEQQTGVKCVEYPSLPESEVQLVLQRVEDAEQEAIREIREDAGERNLEKESRQLTTARKGKRDRGDTDMGYDDAKHGTSDFATLRMRREHESIFEMTKKEQHRSLWAKRREAKKHAKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4V0</accession>
    <name>A0AC62A4V0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">40S ribosomal protein S9, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3520080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="XUY36840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="189" mass="22065" checksum="4E1EF89CF4363573" modified="2026-01-28" version="1">MRNYNNFNRVWKAPRRPFEKERLDREMKLCGQYGLRCKREIWRVNMTLSKMRRTARLLLTLPENHPRRLLEGSAIMRRCHEYGFLDEEKDKLDYVLSLTVPDILERRLQTIVFKAGLAKSVHHARVLIQQRHIAVAKQIVTIPSFIVRVSSERHIAFADASPFGNGRPGRVKRVRVKAAKRHAAGGDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A504</accession>
    <name>A0AC62A504_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3420380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="XUY36802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="250" mass="26752" checksum="CC2A1C31E599BC44" modified="2026-01-28" version="1">MWGAFGTVVRIYEFTTPDALGELPVTHSRIACVVLDACLKNEGLYSKVGQGLNSMGHVLPREYTDVLNVLLGRAPPVAIAEIRKTICAETGREIEELLACFDEAPVASAPIAQGHQAWLPPPADGSSPEPQRVAVKVRKPCISTQSVWGLCMHSAIMMPLNVLFDLPTDWSRKTVCDALARVIGGKGARRPRPISSNARGCRRHDGRAPDHTTGPATPQGEEPPRRATVCRGGGRRGVAACAHVSGLVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5K1</accession>
    <name>A0AC62A5K1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histone H3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1620010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="XUY37012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="66" mass="7238" checksum="D87F239EB5F19D1A" modified="2026-01-28" version="1">MPCARCRACRRRGGPALPEQRDPGDPGGVRCVADGCHEPGQHPREACVTVRPKDVQLAVRLRGERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5S3</accession>
    <name>A0AC62A5S3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Elongation factor 1-alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1720120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="XUY37102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="449" mass="49058" checksum="C7CA18E3C4A6A3F4" modified="2026-01-28" version="1">MGKDKVHMNLVVVGHVDAGKSTATGHLIYKCGGIDKRTIEKFEKEAAEMGKASFKYAWVLDKLKAERERGITIDIALWKFESPKSVFTIIDAPGHRDFIKNMITGTSQADAAILMIDSTQGGFEAGISKDGQTREHALLAFTLGVKQMVVCCNKMDDKTVQYSQSRYEEISKEVGAYLKRVGYNPEKVRFIPISGWQGDNMIDKSESMAWYKGPTLLDALDMLEAPVRPVDKPLRLPLQDVYKIGGIGTVPVGRVETGIMKPGDVVTFAPANVTTEVKSIEMHHEQLAEAVPGDNVGFNVKNVSVKDIRRGNVCGNSKNDPPKEAADFTAQVIVLNHPGQISNGYAPVLDCHTSHIACRFADIESKIDRRSGKELEKNPKAIKSGDAAIVKMVPQKPMCVEVFNDYPPLGRFAVRDMRQTVAVGIIKAVSKKDGSAGKVTKAAAKAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5Z5</accession>
    <name>A0AC62A5Z5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Elongation factor 1-alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1720150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="XUY37105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="449" mass="49058" checksum="C7CA18E3C4A6A3F4" modified="2026-01-28" version="1">MGKDKVHMNLVVVGHVDAGKSTATGHLIYKCGGIDKRTIEKFEKEAAEMGKASFKYAWVLDKLKAERERGITIDIALWKFESPKSVFTIIDAPGHRDFIKNMITGTSQADAAILMIDSTQGGFEAGISKDGQTREHALLAFTLGVKQMVVCCNKMDDKTVQYSQSRYEEISKEVGAYLKRVGYNPEKVRFIPISGWQGDNMIDKSESMAWYKGPTLLDALDMLEAPVRPVDKPLRLPLQDVYKIGGIGTVPVGRVETGIMKPGDVVTFAPANVTTEVKSIEMHHEQLAEAVPGDNVGFNVKNVSVKDIRRGNVCGNSKNDPPKEAADFTAQVIVLNHPGQISNGYAPVLDCHTSHIACRFADIESKIDRRSGKELEKNPKAIKSGDAAIVKMVPQKPMCVEVFNDYPPLGRFAVRDMRQTVAVGIIKAVSKKDGSAGKVTKAAAKAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A646</accession>
    <name>A0AC62A646_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tuzin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2020040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="596" mass="65669" checksum="7E1B22443856FDA9" modified="2026-01-28" version="1">MLGPATRCCLLTAVRRSAFAQPGLEGLRIAAYAPAEPGVPPSPRRLPVAVGRVVAQLSPLVFAVDFRDSPPPPAVSLGSRVYVAYEREGAAPLPQQGGGVVDDAPGHGFLMGGFVVRVNLNGTLGVLLENNRVDLGIPPERIAVTEGVCKFVRHPGYLQVAEWVRSAGLSGADEVEGTACMLYHRGWRAERLHLLEAPDTHCMAHLSQRSRMSLMEKAEWQRNHHRQMRSLSSERVKERDRRYMAAKYAGILSASVAFCGAFSLFGWNYKNHLTHQRTSQMRFAVRMLCKEAPPGASTTADAAHQLSRQTRREALERWIRPVFQQLDTAHPRIAVITGSFGCGKSSLCRAAMREDGMVGVVVDVRVREHPLRRVVMALGVPHVEACGDALDFISEACCRAKSMMGGKTPVSVLGLREADSLARVYNEALALACERRVCHVVVELPLEALTVTSTLLPRLDFYTVPNFSRSQAHEYIQHRLDALDTEAFLDTVGTSRADLDELLAAAHQRRVSPAEYTSERLLRAMRQLQAAWGDDAQLKTAVKRLAQRPYGEGRHVGLDGSSLSHPSLRDVVLYNPVQDAWHFRSRVLHTAAACLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6B1</accession>
    <name>A0AC62A6B1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATG8/AUT7/APG8/PAZ2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0920120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="XUY37329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="124" mass="12846" checksum="4224028B6550883B" modified="2026-01-28" version="1">MSAYVSSTPLEARVARCASLRATNAVPVVVEEAQARGGKAHFSALPRETTAAQLVAAVRAFRGVAANKPVTLTVAGCSVSPSATLGELHDACKQADDGMLYVAYTAERSMGAATWKPCGSCSWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHY0</accession>
    <name>A0A088RHY0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_040610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="AIN95385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703707.1">
        <property type="nucleotide sequence ID" value="XM_010705405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHY0"/>
    <dbReference type="GeneID" id="22572020"/>
    <dbReference type="KEGG" id="lpan:LPMP_040610"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040014800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_040610"/>
    <dbReference type="eggNOG" id="ENOG502SJGV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264917at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038896">
        <property type="entry name" value="RNF170"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22894">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22894:SF5">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="132"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN95385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="332" mass="36267" checksum="8B381914A16FF65A" modified="2014-11-26" version="1">MEPRRRPELTFAQARYVNTSHAATATLPVGCNFFASVSSGGSIAMNFLCVAVPVLALVMLILWVARFGVMCLEAQQMRHRATHWGTLPSYAEVQAVAAALRPKRQAQSQEAAEDTTPAAATAATEARDNMHCIICFSTVVDHPVELLPCGHQKFCAHCLVRIWQCSGMYRRLRCPLCRQPAELLCPVPVADSKPSVDDVLLLRKYNGGFCGTTKLSLLDRCVLRLRVMTHARLLPIVIGLRIVVLHVTMFTYILLPASLTEVTGVAQQPPQQTAQPRVPSSAFAAAYASAVHAFTAVVYTAATYADDLFLVAVSIILTGHLLQRALFKDLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIS8</accession>
    <name>A0A088RIS8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_080840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="AIN95892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704214.1">
        <property type="nucleotide sequence ID" value="XM_010705912.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22572546"/>
    <dbReference type="KEGG" id="lpan:LPMP_080840"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_080011100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_080840"/>
    <dbReference type="eggNOG" id="ENOG502SMHK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267130at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="274"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="465"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="745"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="915"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1008"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1075"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1134"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1221"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1263"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="573"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="277"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="294"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="316"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="778"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1134"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1287"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1323"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1341"/>
            <end position="1355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1370" mass="141394" checksum="5295AA75D5631D60" modified="2014-11-26" version="1">MEPIEPAQRLERPVAPPLSPERDDDIDEDEEDESDVSTEIESEVLSQQFKSLPWPFPAVTLSLGISPSASTRRGISPLASDQQTCVSGSSLTVWSGAQVVYGGDTGTVWASGLGFSRFEKLRAPPRSGTSGASPRAGAGAASKGLMTTIATPTPATRPMAGTTPATIAPITTVTSSHCELTSKNLDRLRETRGPSDALQVAHWKANTQRTGVPLPAVIAVGRARSDYAAGPGGTRVSRASALLKQQAMPAWQRGVIYSGARALADVPARVAATTAAKSDDGLKASVDGLREEQSATADVTRTTSLTPPSAVGQDAHSCHDDCLPLRAEEDDDSDGRRGVASGDGATATTAPQFSPAATPLAEAAPGVSHSTNKGDNAHALVKHQHLGPARAHYQGQILQLEDCTATGIDETSLLPWRAQASRAATRAGATTTGSTTSATCGVVHGTRTNLASALVGEKKSALGTSSQYMTGGRGVQAPRGISVAGRGTRSGTLLPSSVPPFEKEVEHESSEAVCGTKQLSLADHVREPNDQAASGIDDLLGSCNVGMVSPKNARRLVVHLPTLPQTHPAVSALVSEKANRDGLEAELRSVDQRNDEAVNHRGGAEGMSLSPALTQRVRSVLSSSSPTTSSRPPFLSLTAIGVGSATSGVLRSATQTSPRLSAALQRITMPHKPQQQMRPAVIISSTGTTDVPLSHQLLTTVTVTSPSNTGDLHTSVAQGSRLDPSRCSAVRTGITKCSVSCDTRMPSSADCLPSVGSTQPPLSLRTPDGGGGLRWQLSASSHTSSAGASDQRSRSGRAHNANSISSASMASSLHEVCAPAATAEHSSTTVPSFHSGLKSEMLLTLDEQAGAAGLNSNHVDRGSNTTVASTKATTLISAVPAPATTSAVRDHISGSAGKPQIVAGASAEVALATSPPAGIGAGGSEKFRGSSVQPASRVRRTPAPGWQPRVGGRINLADRRTSKPVRLGNAALTPSEVTSSVTYAVTCAVRDRPRTLASLDGCVDQSPVQATDTAGSDIDAAGPSVQADASDSPSAAVVAACSGNAEMMPGMWKLTHSRTLMQTDRRSMALVLPSPDDDGAGNGVPAAGVRGCPGHSRPRSHSLPAGALPSAGDTSARASVDLLSLKKRSARIDQAAARQPLQQQAHRPESLPYAAPGAGDGGGCGLRQEESHHTLHNPPVAHTNKVKGNIRTAPSANTVAAGGDALGQLLLLHSMHAIGDPGSSLEREAERAPGRLPTLGPNSTGATVNPAWLSSPNDLGIVGGHGDQSRVSAGRRKTVSVIRESPSARSRCNTCSDRSGSDTDGHHRYYPRRLITLPDTVEPQEHSHDDGVGESQERSKRAPARKKPPPHRRRSANVSLPEDTEGGKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJ97</accession>
    <name>A0A088RJ97_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase</fullName>
            <ecNumber evidence="6">4.1.1.130</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Coenzyme Q biosynthesis protein 4 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_091430</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Lyase that catalyzes the C1-decarboxylation of 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid into 2-methoxy-6-(all-trans-polyprenyl)phenol during ubiquinone biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + H(+) = a 2-methoxy-6-(all-trans-polyprenyl)phenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:81179"/>
            <dbReference type="Rhea" id="RHEA-COMP:9551"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:62731"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="4.1.1.130"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of a multi-subunit COQ enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion inner membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the COQ4 family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.130" evidence="6"/>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN96057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704379.1">
        <property type="nucleotide sequence ID" value="XM_010706077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJ97"/>
    <dbReference type="GeneID" id="22572713"/>
    <dbReference type="KEGG" id="lpan:LPMP_091430"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090019800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_091430"/>
    <dbReference type="eggNOG" id="KOG3244">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4249at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120539">
        <property type="term" value="F:4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03111">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007715">
        <property type="entry name" value="Coq4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027540">
        <property type="entry name" value="Coq4_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05019">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN96057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="187" mass="21272" checksum="87BB5152C5BC480A" modified="2014-11-26" version="1">MKNCMMADQRGRSILKHQPVVGDEVLEFSRGLAPSTFGFRYAAYMDRNHFLPSGRTAVKHIADPTLAYVMMRYRQCHDFVHVITGCGRSVEEELAVKVFEWKHTGLPLGLLSLLGGASRLSATQLAHMRLFWEWASHNAPCSRHDKPAVPMYLNVPWEDMLAKEYDEVAAYTGITPLPVFLKKHQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJD3</accession>
    <name>A0A088RJD3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_081070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DDAH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="AIN95915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704237.1">
        <property type="nucleotide sequence ID" value="XM_010705935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJD3"/>
    <dbReference type="GeneID" id="22572569"/>
    <dbReference type="KEGG" id="lpan:LPMP_081070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_081070"/>
    <dbReference type="eggNOG" id="ENOG502R1ZC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26679at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016403">
        <property type="term" value="F:dimethylargininase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006525">
        <property type="term" value="P:arginine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000052">
        <property type="term" value="P:citrulline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045429">
        <property type="term" value="P:positive regulation of nitric oxide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033199">
        <property type="entry name" value="DDAH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12737:SF9">
        <property type="entry name" value="DIMETHYLARGININASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12737">
        <property type="entry name" value="DIMETHYLARGININE DIMETHYLAMINOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="220" mass="24350" checksum="E7897A18A38226EF" modified="2014-11-26" version="1">MTKLAVVCRAVPSALEKQTCKLTRIERQTISLPIVPVQHRAYVQVFKDMIEEGHSIELPELSELPASVFVEDVSMLYSVCAVAPPGGGLDSGHGEGSALGERSHSGTAHCWRRRRAVRFEFEVHVCEQVDALEQVREYLGKPGMEYVPCAVKSCLHLRCAASFVWENTLPLNLKWIDPATFTPCGLSVVEADPGELEQRECAELLRGDARQDIAHGIDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJE0</accession>
    <name>A0A088RJE0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_100280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696750.1">
        <property type="nucleotide sequence ID" value="XM_010698448.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22572764"/>
    <dbReference type="KEGG" id="lpan:LPMP_100280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100008000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_100280"/>
    <dbReference type="eggNOG" id="ENOG502S2GT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273821at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="158"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="600"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="651"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="842"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1293"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1554"/>
            <end position="1573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1587"/>
            <end position="1607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1628"/>
            <end position="1647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1768"/>
            <end position="1799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1836"/>
            <end position="1889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2054"/>
            <end position="2078"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2210"/>
            <end position="2285"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="558"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="654"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="687"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="889"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1317"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1637"/>
            <end position="1647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1839"/>
            <end position="1848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1855"/>
            <end position="1871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2210"/>
            <end position="2221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2239"/>
            <end position="2248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2285" mass="243084" checksum="AE03F27E222BEDC8" modified="2014-11-26" version="1">MGSVAHGNGSAAARSPAPPSTTTFSANADTPIAETEAGAGTFSSTAAAATLDLPQSEEEVTNYVLYDGLPHVGPASRRAQQRQSEAYYRFQHRIHERTEAAHALVLSANPLSLSVMDSQLRLYRWRVTQAQTLTEATSILQDYVVETAKHGYRVRRRASPLRQSRYAHGRGRATLKQRAQEELERLGLKDTVQDSAGASADGTRMGRGAIAARRHPNDSGASDRHPDQEAEEEEEEGLDDAALKDDVESALPPPPPDTLPRLVLVDAFTHEDLGDIARHVRFVDQEYGLEMLLVLLLPNDAGMMTVSMQGAGFVVTPTHHITMEDAYAAGYDLVLAHSMDNLLVDFFTSEFVSSVGRWRNDVRSKAAVGNYMSLRSVLLGGLDMDALQRLAWDNRVDDAGVLEVLGAQSLSTQGGAQRYGEASRNLLQQQGGAEAEVGAKCSGSGASRCSRSGSVESDADLAQSQGEPILGVGVPRLRRRPTSVAHFGVRLPANQHALHEPILSFSTKRDVFASVMTQEVYPWYSHSRRRCHTSEVGDGAGGAEDDVDVSKHQQRLLQEALEKELGRLLAENESKQASIDAMQEEVERLHRTVAVLRRHHSGAPGAAGDGVNAKTLPERPDSGSTVHLSKQQQVYILKERLEMANDRIMTLLKGGRPSGAPTSPRRRGGRRFSGGSRRPGGGRAGITAQSPEQTSRSRTYSPLLINAIVREAEQMTALDSDANLSLTQLELHLQEMKAASNNAASKAAAGQKQRREREAADRVIRSLQLELKELQGRLDDTDFGNSQTAAESSDGLQARMAGRLQAALEVLEAQTLRIRHLEELRQMDQLLLSATLSQESAKGQKKGAGSNRSPTAGIVGASDNTDDGDRNSSSSADVDEVDALASRRGAARGHRAQRPRATSKKAAKPRFGVESVPAGKKGVAGSGAGAAASTYFTKGGANAVKVIDSDSTQREGMEEAVARRTEAAVQDAVTSLQRSHRQQLAALLQVCKTQLTRVALKLQKPSTSAYAALLQEELSRAEQDRHSAWMRLQFTLNGLGPDQYDATLANGALSSAAAATAPLGALTAMVTPGLDATDIAAAAGPLDGANAVPIGAVTDPQVRCVAASIAREYAAYGLRVAYMTSELQRVKQAMMTSQGHQPESAAAAMPVVADVSPEQLLSACQAAKTYVQATIEGCGSTQAYLEAVQAELVTEQQLRPWCDVKSQQLFSAAHTTPSPSCMVLVPSTLHLAASTSSAAGTQNHALDNAPPWIVSSSDDQVVLLADVDASMRDVADVYATLLRALTPKISGAVVCNSTPASGSEKRASKWRRRPVVSPTQSKATGPQQKAQRQSVATPADKSADDSPDELDSLLPLHQPAGPTMEAAMAMLPLHRDGVAGYQGQLNRLYTAEGAHSVAQRRLYEAILRAYQQHRIHPVHMAAVEYAVGLPLLDLRRSDGGIAKDRSSESLTSEGEVPVDLIFAQAGAAHAQHREVIALLELITPTTARGLLALTRELRQMQGLLDREDDEAVFAGALNGTGPPCTSPVFLSAVDAAVLGCVVDELRWRQWQHSVLPSKDSKDSSDPVPLSAAGAAPSELVTALMLARRHKSRGDSSSTPTEDGGPALEDARGIAHYMAFCAAPERAAGNARSKRRSSVQGSSGSQASEAEDLFHLTDVPLMPSNASGTSPLAAAGSDDSDVGLKVAHELAALFSKRHPQNADGGDDGAAAMLADIYLDDDEGRGAGKFGGDSNKEAMRSIRRELEYLQAVKQQRMWELMMRFELQKERSAGNDSSGSRPAKWGVAGEHSGDGGALLPSIDPDRLTFEVKSGSPAWYGMEAAKRVHNILRRRARPDQIIVGGGPHGGSVGIELSRRTAQPAPSTAGSSKTGNVGSGLPSPEDEGYARSSGEEEALYTLRPYASNQQPNRTDGRATPSIAPLPPLRQHGLSRAQQWHAARAGGVAARCEDQVPLSNPYTQDGSFAGHGYNTTLMAAARYLSPRDVLSLNAYGHMASGGAYDYSDTNQPLYTAGGLIDQVLAYREALMHAAGRVVPMPSSTYSNGAPYCLPLSSSSAPSRQVGMSGNHPYDPQDRQPPSPVPLPEVTSWVYGVPETHASSLVQQQIISSQQQQDTLLFMPRYDRSLLAEVEGRQRARVPPAVPSALVRGHGFLAGAAAGASPYTTPAALAAHRLQAMLSVSMGNPSIATAGRGTALLPTRGYTLHPRRCDSVAAAPPLSSESPSTKQALARANAASAGVDSTVPSSQTSLGATGGGEVRQPHCESFAFDGKDPNLLDRTLGPQEDGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJE8</accession>
    <name>A0A088RJE8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_090140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN95930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704252.1">
        <property type="nucleotide sequence ID" value="XM_010705950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJE8"/>
    <dbReference type="GeneID" id="22572584"/>
    <dbReference type="KEGG" id="lpan:LPMP_090140"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090006300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_090140"/>
    <dbReference type="eggNOG" id="ENOG502RXZZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273140at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37028:SF9">
        <property type="entry name" value="NUCLEAR PROTEIN MDM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37028">
        <property type="entry name" value="UNNAMED PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="563"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="565"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="583"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="602"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="702" mass="79446" checksum="255C7F159784CEF8" modified="2014-11-26" version="1">MAAVQQQQQHVSEVVEYLQLAGRRYREHVELLRQEQAVRDAQRAPFKPKVSSYAQRMGKTSLERQSSSIGARLHELHQKKLALLEEEAQEEAKRRAAAEAQDCSFSPAVTARATRSRRSGSDVTVALIRWGEQRRARQARAQVEATRNELSKVSATPHITAYAEEKARAERGRVLVEVSLTAEAEARRQRRRAAFEKTYPASSRGSTTSARRFSPSISAYASRIELEEDVVSRLYERHGSRGHLAPHHRLYDEEDALHCTFQPKLSAQSVKLSRQYYEEEGEAGTDPCERLFRNTRRTPKYRKSAQPSVFSRQPEISHASRRIVEERRRQLALDGQPSALGYSPASRLCPGSTSVVVTHEKRAFKKALTAREVEEQTTPTFTPSVSPVSEELWRQRVSALKASGVARSTKEARELLWRKAEKRREEEVLTLQEQRRRQEAAECTFRPKAGRPPQRRAGYVAMPIEARTALWAQQRNRRLADLRAELNESTVEECSFQPHIDPVFPLPRSDAKPAWGVEAFLERQAEARRQREEAEQWWRPQYARAPVPKTLCVSPRCLPPYHGVSQSSQQRIASASRRIASEAEGEGEEEESFEQHWIRPPASTSLTASSFSRVSQQDVPSADSSPANVMRQPPGVLFPHTTDIPRRGPYQWRQTTAPGCPEAAVDEDGAHCTPAPLSWRKPLRYQPVSSTAAGPRARSFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RK48</accession>
    <name>A0A088RK48_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphatidylinositol 4-phosphate 5-kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_051080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="AIN95549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703871.1">
        <property type="nucleotide sequence ID" value="XM_010705569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RK48"/>
    <dbReference type="GeneID" id="22572186"/>
    <dbReference type="KEGG" id="lpan:LPMP_051080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_050014900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_051080"/>
    <dbReference type="eggNOG" id="KOG0231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="423343at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215:SF14">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="684"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="694"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="714"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="725" mass="80442" checksum="EE141F349E475255" modified="2014-11-26" version="1">MSDDGSEAGVELPQMWQLIHPTYNHADSGEDDTDDEEVDMASNDTAHGGRPADYVKLKKSAPRLGQLIRFLNDMEEEDLQGMLLEKDPVTQQTLLQWATLNNHFMLVEYIVKRMKRAAFFDAESIEVVVYDRWAEMSLELPTAAEVAERQKQRENEKAKRLAERAMANGGGDIDEDEESEEEEAVEPMPEELVYDTLEDYHSEWGDGGVGVVKRIGELGVYVGPRLPDGTKQGLGQTLFPSGDCYTGEYKENQRDGRGVYWWPKGGALYCGEWFRNMRHGYGRMVYPDGSRYIGWWVHGKRSGKGRYVYADGSSYDGAWVKDEKHGGGTYHLLDGSSFIGAFHHNEFVSGEWRLASGTVRYIGNFEKGAPVGAGVYVHRCGLKAGTFQQEGAYSTEDKAWVPSMLKVTTRMVPHMELVVPPQPSGLTRVPMEFGPGCTGCTMADLIRVANYAPLLRWVASLASAAKDVVIGGVELKGVELRGVEVQSMRYDDANPDVITEVTILPILVDRVGKRVHLPSESVTLKPSVTRLMILLEAPGAQPVVVLEKSLQSSSPDERHQQSRLPAVRISEDSSVSGDVVDAVGPTLRLQLTSTKFMALLLPSMRCNPMHGNAEESVWMYAQEVHRETMTQLQYKLQQLSAESREPMTTTYMAVPLSDVTAISTDAMTAMAAANVQQRRAAQLLPSATVAPQRAPTPPPPTLEPRPELQPLYDAKTRRNEAEVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RK63</accession>
    <name>A0A088RK63_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane insertase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_111140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696961.1">
        <property type="nucleotide sequence ID" value="XM_010698659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RK63"/>
    <dbReference type="GeneID" id="22572979"/>
    <dbReference type="KEGG" id="lpan:LPMP_111140"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_110015100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_111140"/>
    <dbReference type="eggNOG" id="KOG1239">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2148490at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20069">
        <property type="entry name" value="5TM_Oxa1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428:SF13">
        <property type="entry name" value="60KD INNER MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="OXA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839008" evidence="6">
        <location>
            <begin position="30"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN96308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="443" mass="50160" checksum="0DEA965712137914" modified="2014-11-26" version="1">MHLGSRLACAPVALAATTLLHSGAPAASACWWLSVRHNCTPTLSPLSSPISCGYGVGSCRGGMTGALYVQQRGLSWNPLDWGRSDVGRSTNPQLEEELPEIFARQPTEVDDYIRPDKSLFERLEDFWDWAVSFLQPVEKQVEIMRSLRHDGFMSLDLGGWGHVFFFYGLCMRVLTLIPSLYSHRNSLRMAHIGPQVSEITNSQNKVKNDRTLSSAEKRVIKDGYNRMKYALCKRHRCAQWKSFLTVLTAPITMSAFLSIRRLAMYETDLEMAPFLWVKDLTMPDPTYALPAICAGMFLLNFEMNQRMQRGGRSASSMYVRWAVRASSVVGVYFFAAQPSAMFAYWIGLSTAGLLQPVLLRWQPFRDFFRFPEPPQAAKSHLISEVKGPSLYERLFATEAEKARLEEQRKADRIRNSAARIETVDDYEVVFNDDVKNAPSGKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKB9</accession>
    <name>A0A088RKB9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Argonaute/dicer protein-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_110590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696908.1">
        <property type="nucleotide sequence ID" value="XM_010698606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKB9"/>
    <dbReference type="SMR" id="A0A088RKB9"/>
    <dbReference type="GeneID" id="22572924"/>
    <dbReference type="KEGG" id="lpan:LPMP_110590"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_110590"/>
    <dbReference type="eggNOG" id="ENOG502RSJT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271295at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="2">
        <location>
            <begin position="282"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="897" mass="100532" checksum="D03A0B74B5AA7DAD" modified="2014-11-26" version="1">MLALNVGSQYPGRGRGRGRGDGGNRVHKHDGINRYHGGFRGGRGGGGGFRDGDMRECRERESWAVSAAQANARTLARVPVPVETNCFPIDLSEGRFHNYIVSFEFLENATDMAGDMWKISLQNELLRTIRKNRTAEKRTRTSAEVEDLCVCTGQAILAPAKLSVEDGFSIECTRKEKVSRDNTEERHYRVRIRYDGEVSLKLPEHAQWVNKIIAFGLADTYSEHIGSDYVDMKSTVERGGDLVTMDAISLNALRIVKQSGSTTAMMDVLQLDVSTKASTKTKCSDEIRRLRQQNPQGFRRAVNEALVGISVTTVFGEPTFLKVKAIDFNILASSPTMFKTNPEETFVEYFKRKYDAIIDPTLPMLYCVFADRTKMSRRMPYPADSLLLNKLNEAQLSKLPILCSIYPNERIKRIKAALERVLASPLMITVLQQYGVRIQPQFVKVSGRVLPAPTIYVPSGPNMFNRINTAEYTGQAGFALGLKDLQHPSQPCEFKTLLMDEYFMHGNITHWLQKYNVALPSPRKTSFDSAAQRITEGSGTFAMVKLRTKEAGAYNNFKERFARGSIVSQMAVVDLTRNVPQMITQQVAAKIGQLCFVADVDEAGKSFACRPLLIVGAVVGTAMNTMLEKYKSINVRLYTITFVAFLANGKSWKPYCMHHQVKGEEHVLYEDSDAASSHMSSTTLTVRRQNANEVLNNRFPDFLKEVTAHFKLDGKGSKGTMVLYRGAMTDAEVGFTANMDLVMEQVLPNWDTATVVVHPRSHFRMAWDPTAVFPRETASAYAGFSNVPRGFSTTDCRIILADSDPYTPVDSFYLSAANCTLGHATNTYYLVQKRAASISLMDLQKLTYNMCYMYPNKPDALPLPLPIKCAYEYARKYGSLKSVKELPTRMRPTMHYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKT4</accession>
    <name>A0A088RKT4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPN-loop GTPase</fullName>
            <ecNumber evidence="5">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_131150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="5"/>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697196.1">
        <property type="nucleotide sequence ID" value="XM_010698894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKT4"/>
    <dbReference type="GeneID" id="22573225"/>
    <dbReference type="KEGG" id="lpan:LPMP_131150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130016300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_131150"/>
    <dbReference type="eggNOG" id="KOG1532">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="243313at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17870">
        <property type="entry name" value="GPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030230">
        <property type="entry name" value="Gpn1/Npa3/XAB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF8">
        <property type="entry name" value="GPN-LOOP GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="196"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN96543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="303" mass="32615" checksum="7CE985E4ECE6C2FA" modified="2014-11-26" version="1">MPVVILVVGMAGTGKTTLVHRMQHYAHANSIRSYFINLDPAVTHTPYNVNIDIRDSVQYGEVMKKYRLGPNGAIMTSLNLFATKIHQVVSLLEKKEMLDWVVVDTPGQIEVFTWSASGQLIAESFGAVFPTVLLFVADTVRCVSSPQTFVSTMLYSSGIMLKQQVPLVVVFNKTDVVSADSVVLWMRNNDALDEAVTNPRCNNQSRGSLSGEPGGDEAADWQGEGTRVGEAALCSKDVLLTSQGSSYAGALAQSMSLFLHEFYEDLPYAAVSAASGAGMSELAASIERGKQQALEAKAAKAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKW7</accession>
    <name>A0A088RKW7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nascent polypeptide-associated complex subunit alpha-like UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_140510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697285.1">
        <property type="nucleotide sequence ID" value="XM_010698983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKW7"/>
    <dbReference type="GeneID" id="22573318"/>
    <dbReference type="KEGG" id="lpan:LPMP_140510"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140010300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_140510"/>
    <dbReference type="eggNOG" id="ENOG502SAUX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="285219at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052617">
        <property type="entry name" value="Huntingtin-int_K"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31184:SF2">
        <property type="entry name" value="HUNTINGTIN-INTERACTING PROTEIN K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31184">
        <property type="entry name" value="HUNTINGTIN-INTERACTING PROTEIN K FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="11880" checksum="850262670D1D683A" modified="2014-11-26" version="1">MTRQADEQKSMRNVTGSGEAEKTSKLRTDDLPALQERMKKLHAEVTQQTEAKEQRARELAAVPVADVDIQVVAAALAVTPECARCRLQKKNGDVTAVLRDAVGLPKARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKZ5</accession>
    <name>A0A088RKZ5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_140150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697251.1">
        <property type="nucleotide sequence ID" value="XM_010698949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKZ5"/>
    <dbReference type="GeneID" id="22573282"/>
    <dbReference type="KEGG" id="lpan:LPMP_140150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140006300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_140150"/>
    <dbReference type="eggNOG" id="KOG1715">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="250175at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_bL12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_bL12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_bL12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987:SF2">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="ClpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein bL12 C-terminal" evidence="3">
        <location>
            <begin position="114"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN96598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="181" mass="19330" checksum="E53E6C2264E0E2A6" modified="2014-11-26" version="1">MRRALFASVLTSRSAVACRHSTAKPADGNAKLDDLAAAYSQLTLREVSDLQRLIFKKLGHSDDFYEKALLRGLSGGGGAVMMAPTAAAAAAPAADAPAAEAVKAEKKKVEKLTYDVKLEKYAPEIKIKLIKELRTVTNLSIADAKKAVEKCPGLVATNMSKDDAEKLKGLYEKLGAKVELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLD3</accession>
    <name>A0A088RLD3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DEAD/DEAH box helicase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_090830</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN95999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704321.1">
        <property type="nucleotide sequence ID" value="XM_010706019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLD3"/>
    <dbReference type="GeneID" id="22572653"/>
    <dbReference type="KEGG" id="lpan:LPMP_090830"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090013800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_090830"/>
    <dbReference type="eggNOG" id="KOG0331">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0344">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10256233at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF13">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="11">
        <location>
            <begin position="113"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="144"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="497"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="756"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="7">
        <location>
            <begin position="113"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN95999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="776" mass="86693" checksum="B0F3545FE6597BF7" modified="2014-11-26" version="1">MAGAPARLATVGCGCSAAALASSLSCVQNSNMRIAGGSSSSLAFSSLSWSPHRCQVRTLIVPRQLKAYGGTFSQSIGERVSHAASHQVLQSLSPSRAARSPLLAKPVKTKTLDSFAGMLVSPALQGALADMGVSTPSPIQQTAIEAVLQHKNTVIAAPHGEGKTLAYLLPLYQNMVKDRDVYRIPLRERRPRMLLLAPTKELVEQLQAVCARLDAATGLTSASFTSRKRSKYHLSRLLKNTMVDVLVMDPKLILRLLRTRRLFIEDLRYFAVDEADAMMSSLHDHDAMQLLMKVQKRNQFKYLWPVQTQYIFITAYMTRKLEYIVGRKISDPVTCMFRQQMHRPQARLRHRFYAIRREPEKFTVLLHLLRKNGHVPLPVDTDIAEVDVHTRPRKLSGSLAEWHEAVQRHAWKEQQVQQKNADNSEAVTDEVVDVDETGIEAADGPSAAVPSARPSATVSSATGHDYIHDAYARYTLECVRPLHWEHLTTVAAPFTCPIARTVFAEGRRTIVFFRNIDATTALFHQLRSAGFAVSLLHASLPYKVRKEMYADFASGRTNILCATDLAARGLDLHVDVVINFDVPTNALTYLSRCGRAARMGREGQVLNLYKKHQGVIISAIKAFLKNNLPMEGLTNYKPDMMQPRYAEWRTHKINALARSYVSLITRKTIPAHLERTYVHHNATWRPVFHPQKTGIHGGVAPRQQQKLMDRVMEQAVWFRRGQLARRKGGRAKFGSRTMKRGVWNDIGGIASREIVNEAQNPSPAGPNFGPPSGPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLE9</accession>
    <name>A0A088RLE9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Vacuolar protein sorting-associated protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_090990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the VPS13 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_010706034.1"/>
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    <dbReference type="KEGG" id="lpan:LPMP_090990"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090014400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_090990"/>
    <dbReference type="eggNOG" id="KOG1809">
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        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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            <end position="340"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="3">
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        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF12624"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AIN96014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="5330" mass="575792" checksum="82FA0F655E3E31FF" modified="2014-11-26" version="1">[encoded data, 5330 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RM26</accession>
    <name>A0A088RM26_LEIPA</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009386">
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        <property type="molecule type" value="Genomic_DNA"/>
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            <dbReference type="EMBL" id="AIN97097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="418" mass="46140" checksum="72FEF9A9E73FC1AA" modified="2014-11-26" version="1">MASEDIIVFLDIVDNTVNMVRGDGSEKKTLFTTGCVCPDGIGLDLSAYNTSNNPDDIVVWWGNMGAMKPCPEEKDGADWHDADGFLVRAPLFGNNSAVELVEVTAPRHLIRSMATFHAPGHLPLITTIKQVAVSSDGCSVFFCDREGHCVKKYNVKTKEVVPLLSLDTLAALANGMSEEEAYASPVEPNSDEDKCRFCVGIALDEVHNLIFFTAKGPSKGSKGRILAAPYYYKRRHLPSVIAAKTSASEGVIDPTTVVTLLDHLTEPIDLLLDSKENYLYWTNRGDAEEGGSSLNRAPVTYDPRSWKPHLGEMELFLGGFNEPIGLAWAASLENCMELPEIFKGTLRQYMYVTDHGHLWRCNVEERTKEVIYECGSKNVLTGVGVLRIRPEEEKTEEKSEHGCAGQVYTEKTPTPCRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMN8</accession>
    <name>A0A088RMN8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside triphosphate hydrolase, putative</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">LPMP_171000</name>
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    <organism evidence="2 3">
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            <taxon>Trypanosomatida</taxon>
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            <taxon>Leishmaniinae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
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        <property type="nucleotide sequence ID" value="XM_010699489.1"/>
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    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170016300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_171000"/>
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        <property type="component" value="Chromosome 17"/>
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    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35615">
        <property type="entry name" value="PRESENT IN THE OUTER MITOCHONDRIAL MEMBRANE PROTEOME 22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35615:SF2">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
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            <begin position="51"/>
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            <begin position="455"/>
            <end position="477"/>
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            <begin position="186"/>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMZ6</accession>
    <name>A0A088RMZ6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidylprolyl isomerase</fullName>
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        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">LPMP_190840</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="1"/>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698080.1">
        <property type="nucleotide sequence ID" value="XM_010699778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMZ6"/>
    <dbReference type="GeneID" id="22574138"/>
    <dbReference type="KEGG" id="lpan:LPMP_190840"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190016300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_190840"/>
    <dbReference type="eggNOG" id="ENOG502SFB4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839013" description="peptidylprolyl isomerase" evidence="2">
        <location>
            <begin position="32"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="3">
        <location>
            <begin position="83"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN97427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="204" mass="23209" checksum="51D065C05334FB6B" modified="2014-11-26" version="1">MNRFSTMRCVFAAVATLLLLLLTLCVVSVEASYWSNEVNRVRTYTAFNYMARMAKQPNVSALPSGVLFTIERRGFGDRAPALEDKCEMHYTIHQRFPDIVESTRHNPYPVCRSPSQLISGMAEAMQLMREGDRWHLYVPYQLAYGMEGCKEKKVAPMSSVRVEIELYKCKSPSGKTSTEIDAYLAQFIKSPMPVKTEPLDYADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNC2</accession>
    <name>A0A088RNC2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNaJ chaperone family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_141310</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697362.1">
        <property type="nucleotide sequence ID" value="XM_010699060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNC2"/>
    <dbReference type="GeneID" id="22573398"/>
    <dbReference type="KEGG" id="lpan:LPMP_141310"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140018700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_141310"/>
    <dbReference type="eggNOG" id="KOG0624">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1726119at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051727">
        <property type="entry name" value="DnaJ_C3_Co-chaperones"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140:SF2">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="J" evidence="5">
        <location>
            <begin position="380"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="403"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="407"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN96709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="519" mass="58323" checksum="4DCF6F5516978F1F" modified="2014-11-26" version="1">MLAAGDKALGQGRGHYQEALSKYTGVLTRWPKNERALYSRAELYSMMRQRAAALDDVNMLLSISKEHPQGLALRMSLNMQLGNLLDAHQDGQLLVRVYKALNKPERAQKTAEQVRHLERYTARWTALSDLWSQPVAAYTVVPNDAGLLRKYKECVDLLAKVIREFSSDSVELRLRRAACALASGDNIAATQELKYVTQRSPQNLDVIALNAQALRSLGALDQSISELRRCLSFDPEHIPCANLHKLIRQQQRMMNNIVKGLQDKKFETVIQLIAEARAAEPNAPYEEQLAAWHCEALVGLRNTDEGIRVCQALVDRYDGASSPTVFEAHIRLVELHLLDDNTAAAEAALQRAHELRQHDSKVEEMRVTIEKLKRSGARKDYYKILGLKKTASAQDIRRAYRKLAKSSHPDQLRSRDMTEKERERQEKMFRDVNEAKEVLLDEEKRARYDNGEDVNQPSAQRGEPSFGTSFAGGFPGGFPGGFPGGFPGGFPGGFPGGFPGGFHQQRGGHHQFFFFNQEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNJ6</accession>
    <name>A0A088RNJ6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Malate dehydrogenase</fullName>
            <ecNumber evidence="3 10">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_200210</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 10">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3 10"/>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698220.1">
        <property type="nucleotide sequence ID" value="XM_010699918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNJ6"/>
    <dbReference type="GeneID" id="22574228"/>
    <dbReference type="KEGG" id="lpan:LPMP_200210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000028500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_200210"/>
    <dbReference type="eggNOG" id="KOG1494">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="755699at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000268">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000018">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF48">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="11">
        <location>
            <begin position="16"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="12">
        <location>
            <begin position="166"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="21"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIN97513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="343" mass="36589" checksum="FA2AB3FEF0DC6F01" modified="2014-11-26" version="1">MSFLFRRSPAALKKAKVVLFGCNSTVGQPLSLLLKLNPHVEELVCCSTAADDDMPGAGIAADLSHVDTLPKVHYAADEGQWPVLLRDAQLILLCFGSSFDPLHQDRDRALKVAAPMARRIMDAVAASDAKGNIAVVSSPVNALTPLCAEFLKASGKFDPRKLFGVTTLDVIRTRKLVAAALHMNPYDVSVPVVGGRGGVTTCPLIAQTGLRIPLEDIIRISGEVQSYGVPFEVIVGTGLHDALSTEAAPPVALSLAYATCDFSTSLLKAQRGDVGIVECALVESTMRPETSFFSSRVELGRDGVQRIFPMGALTTYEHELIETAVPQLARDVQAGIEAATRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNN3</accession>
    <name>A0A088RNN3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tuzin-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_201630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698364.1">
        <property type="nucleotide sequence ID" value="XM_010700062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNN3"/>
    <dbReference type="GeneID" id="22574372"/>
    <dbReference type="KEGG" id="lpan:LPMP_201630"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000016800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000029400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201630"/>
    <dbReference type="eggNOG" id="ENOG502SKGD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269715at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34157">
        <property type="entry name" value="TUZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34157:SF2">
        <property type="entry name" value="TUZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839051" evidence="1">
        <location>
            <begin position="29"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="715" mass="77377" checksum="44C894D2448977C2" modified="2014-11-26" version="1">MCVRALGRRRLLLPSFLFLWPSLPLCLCGTAEVDAGARTRTPEAHMFRQGHTCSWIGAAQMLRGIACTCVCAARGTGGTAAAPSGAAASALREGCVSSECVPGCSAGDHSASYARTLLCECRPWVCGSVRPGHYRRELRDCMGEALIGVGPTQPANVFEDRPVALGRLVARMWKAAYRLRIFLRGRVGDAVVPRCGGAAPPLLVGVGMRVTVSLEKNPASGGAAVLSGMCMRGTVARVNGDATCVLLRDDGEVELSVTPERIVALGRRRKLLYHARLLEVVCWLRPCMHDPRDAEAVALILFCRGWRVELMHLLQTVDVSSFVFVSNTEQGSICEKAQWEREHRGVLRCAARERLKDRDFRYALAKYKGAISCMAGVLVVTYVFTTNLRAYRREQRDHQLQTAIETLSKAAQSSGGGGALAAGDEPFVVGRKNGEAVVRRVLTEMLPAPPRIVAFTGSAGSGASVLWRSAVLKEGVPHVCVDVRGTEDTLRSVVKALGVGSVDVCGDVLDFVEEACRMARAARGETPLLLLRLREGSSLQRVYRDVAALAFDRRVCHVVMEVPAEALSMASAGLPRLDLCVIPAFSREEAFAHTQRAIDPVSLSHFVDVVGTSSSDVDELIAAVRQRRASAAQYTNARLLKAMRQLQATCASRPELRAALQQLSTCPYDAGQHSGVDAAALHSTALVDIVLYDPVADAWRFRSKLFHTASRCCWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNQ7</accession>
    <name>A0A088RNQ7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Triose-phosphate transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_191390</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698133.1">
        <property type="nucleotide sequence ID" value="XM_010699831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNQ7"/>
    <dbReference type="GeneID" id="22574193"/>
    <dbReference type="KEGG" id="lpan:LPMP_191390"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190021000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_191390"/>
    <dbReference type="eggNOG" id="KOG1441">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5547497at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="10"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN97480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="321" mass="35701" checksum="7B5DDDCE016A083D" modified="2014-11-26" version="1">MSTEQTRILFYLGLNALSSIGIVYTNKVIFVRYGFTYGTLLTAIHFLITTLGLFICRIMGVFEPKRVPVAKILPLCLGFCGFVALTNLSLIYNSIGFYQLTKVLTTPMLVVIQTLYYQKTFSMKVKLSLTAICTGVSLATVSDATANVAGTLIGLSALFITCMYQIWVGTKQKEFQCDSFQLLYNQASLSCAMLLPIAYFADDLAHKYYAPCWPTVLLIIFSGFLAFLVNISIFLVIGKTSPVTYNVLGHFKLCVILSLGFLGFGDPINARIFLGIIITLFGVVWYTHLNMLEAGKKEVVNLQDKHEEKHFNVDENDEKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNQ8</accession>
    <name>A0A088RNQ8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_202030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698404.1">
        <property type="nucleotide sequence ID" value="XM_010700102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNQ8"/>
    <dbReference type="GeneID" id="22574412"/>
    <dbReference type="KEGG" id="lpan:LPMP_202030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200025700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_202030"/>
    <dbReference type="eggNOG" id="ENOG502SQ1C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="261736at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="189" mass="21382" checksum="9BC9E471633D9BB9" modified="2014-11-26" version="1">MLSCPKLPAERSEGQIHYSLRCSLLREERCQRDSLFSQAKEEHRQLCAVCAEESKTEWVREDARRAANISPPEPCPSRYAYKYKAGTTVSVLPVGQLTAVLNQRPSATVDPGNAEENLLEPWESENRVDLQEWELGERQEMLHAFQTILVAQHEHELALREAACKLVMGGATALDWTSYPHYAEPGLHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPB9</accession>
    <name>A0A088RPB9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA processing endoribonuclease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_203020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the endoribonuclease YbeY family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698505.1">
        <property type="nucleotide sequence ID" value="XM_010700203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPB9"/>
    <dbReference type="GeneID" id="22574513"/>
    <dbReference type="KEGG" id="lpan:LPMP_203020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200036100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_203020"/>
    <dbReference type="eggNOG" id="ENOG502S4SA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27226at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.30">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00009">
        <property type="entry name" value="Endoribonucl_YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023091">
        <property type="entry name" value="MetalPrtase_cat_dom_sf_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002036">
        <property type="entry name" value="YbeY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020549">
        <property type="entry name" value="YbeY_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02130">
        <property type="entry name" value="YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01306">
        <property type="entry name" value="UPF0054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN97798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="212" mass="23958" checksum="870952C70BE9C0DC" modified="2014-11-26" version="1">MIFRGLTIAGATPTLRREVRHLINLLLTLEHAPYDTRLNLEFVSLAYMRQINCKYKESDRPTDVLTFTSVGKADRFVNHLLFSDPLEGGDDDEGTHAALATSRECGVAVAAGPTVLKKSAIRAELVDLGDIFVSLDYMRLRYRRYPSTTLPLAPYLHAALVHATLHALGYDHKNPELLQHMARREQQLGRQLAMIARQHPRCLPPLNMWDSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPJ4</accession>
    <name>A0A088RPJ4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_202340</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698437.1">
        <property type="nucleotide sequence ID" value="XM_010700135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPJ4"/>
    <dbReference type="GeneID" id="22574443"/>
    <dbReference type="KEGG" id="lpan:LPMP_202340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200028800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_202340"/>
    <dbReference type="eggNOG" id="KOG0953">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6692397at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045025">
        <property type="term" value="C:mitochondrial degradosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000965">
        <property type="term" value="P:mitochondrial RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000269">
        <property type="entry name" value="ATP-dependent RNA helicase SUPV3L1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004779">
        <property type="entry name" value="DExH-box ATP-dependent RNA helicase DExH18 mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055206">
        <property type="entry name" value="DEXQc_SUV3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022192">
        <property type="entry name" value="SUV3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041082">
        <property type="entry name" value="Suv3_C_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22527">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12513">
        <property type="entry name" value="SUV3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18147">
        <property type="entry name" value="Suv3_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="327"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="384"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN97730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="694" mass="77206" checksum="D08506C1DF7BECFA" modified="2014-11-26" version="1">MCCGGLYAMVWRRPVAAIGASRPLVSPACLRFISGALPSPSTSARQHQLHIACDAIYRSGTAREALRQAIHEPSHENALRLLEEFEKDPGVWRDEAWATAFQNASSHLSRQMDLLLVRFAQWHTVRKAPTKVAMHTPWDWYPQARLMRRRFIFHYGPTNSGKTHAALEALVRARSGVYCAPLKALATQVWYRVKERVPCDLLIGDERVFDGAAEHVSCTVEMAPVDVQVDVGVVDEIQMMADRDRGWAWTRALLGLPAREIHLCGEARALPLIQKLLYATHERKSLLLVEHKRLVPLAVFPSLCSRLQPETVENGDCFVCFSKKEVLDLRDKLNRLPGVTSSAIYGVMPFQVREAEAARFNHGVAEYISASATCVANARDNAASPTTTSPRSSQSRVSSPEAAMPTKHVLVSTDAIAFGLNMNIERIVFTTLRKFDGNGMIELPDATVQQIAGRSGRFGLTRQHAVGRCTVLHERDMTKFSAAMSAQLAPLGKAGLLPTGDILQLFVELDAAKARKASKATLDSNGGSFFELMSRFAASCTESEHFFPCDIHRSLLRLAELLEPVRDLPLADRILFCYLPLSDTSAASLQLIVAYATDHAAGKPVTLRFDVWCAELMKQVERGDPCEEGETPQHRRLQQRSARELATELERCFRQAEMYCWLSWRFGKTFVERERGLELKASIATALARLNGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPP2</accession>
    <name>A0A088RPP2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_203040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698507.1">
        <property type="nucleotide sequence ID" value="XM_010700205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPP2"/>
    <dbReference type="GeneID" id="22574515"/>
    <dbReference type="KEGG" id="lpan:LPMP_203040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200036300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_203040"/>
    <dbReference type="eggNOG" id="ENOG502S6T1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276670at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="153" mass="17523" checksum="28EE280515B2718E" modified="2014-11-26" version="1">MLRLATLRFSTTACSGTGVPAAVGCTGSSGHHINSQQRVLQINSPMSLLRMCYRSIDITVKSRHARTFLKKQLMKQWAERSKETNPAKQRFYMDLAGSFLQALHTERNPKPGKIVNFQLSRQVAYEQKLAEREKSPRTRRVRHMPKEVTTQDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQ24</accession>
    <name>A0A088RQ24_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_204660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698667.1">
        <property type="nucleotide sequence ID" value="XM_010700365.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22574678"/>
    <dbReference type="KEGG" id="lpan:LPMP_204660"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200053300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_204660"/>
    <dbReference type="eggNOG" id="ENOG502S1ND">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267632at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="55"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="344"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="462"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="880"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="987"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1081"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1297"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="600"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="697"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="888"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1001"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1084"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1099"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1120"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1319"/>
            <end position="1333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1342" mass="147400" checksum="12B88663B0BAD929" modified="2014-11-26" version="1">MTHSTYNKHDIPRELQRLIDRTDHGIEQLYQLTGRGAAASTVEIDGRPRAARVVERGQKRGQRCHNRGFQDSLQDERHAEVRRHKPHRSIRRSYSDGRSGVSADLQPRSTVQSSSRRMRDSYNDGSAPSDWQRLRAPVTEHTRQFEHNEYDTSDDDHFDSDKGDALPDVTASDDNTDVYERDEAGEDNDNYEDEGANREPLSVSRHHGQWHASRALRQATIATVGSPSLQAQPPHRRSLPLASTPHRTLNFSNGTAQSSPASLAKPPRHLRRPDLHAPSSHLPGFSSPPPWRQRQERQDSRDLPPAGAASYTPPPASFSALYGSSVASSPSPTAKTTEATAYRAHMAAQQSTQRPTASSAVRRRRSPSQQLSGTPVSDPATPLFMSPGSAQSRSRDESCLHTRSGLRKTRDTAPAGMLSQFGRRWKNIFKELLIDPPPPAPSWATSSPPQRATAAATVASHPRNMPASSSFSSSSCTTVSMGEGRAHEEGAAERGSLPQLRELIPHPKRVHAPPSCTAADLVPVAPAVLPHSATSARAFADARVVEQLRAELQAREEAMLQLRMDHAQALAELRQSLTHERASAAKQTADELATSFSIKEQLLQSSLQTERERLMEAEEQLRLARREAAQRKMDHEDSAHALEVLQGKYATLASSQSEHAAQVVQWRALAEKAAAEVAEHESLVKVWKAREVDWQAREAQLQQLARTAEERREQQEASAQTALAQVEAEFTQTSQSYQDLLAEATKRMSYLEKNHRKYKLLKEAHTVLKGEYEQLVNSSMHRAQQLEAERASLHAEAQELRQQLLQRDSATQQEATSHQEMLSDYKRRLELQEASAAEQVKTLQQHIDTANHTIELLRSQMESLKQDVLEEQAQHQQTQMKAAQTELQWKERQHEHQRSAAAYKVRSEDTIAQLKRQLREKDTKMQALAASAAEPLQRLRQQLDDERGRRARLEEQFRAYKKKAKEAEEQAVSEMRREQLRTALLTPITSTGSPHLRFAHSATATPSPSSSSVPCSSGANAISGVGKVWLESAARLDEPAHPAVLVSARVARDVQREGRLTHPASLRGATAPASSVLAKAHVAHSREGDAADRRRATAGHSQVTSLTGATRFTSEESGRLARLAPSAAAPSPSSRRTTQVCGEDEGERHDAQVRRTSSPGTAVAATDVSAISPSATVESLSGISRTSPCTSTLMAGEDDAVGADGTVKSSSVQVVESTLSLQPHPTNSTRHTNTSAARVPAAVDDAMATRVYTDPGVQAHEYRMSSFHTSASEVLRRISGSREEFLAQCAAIVKSTAAAGRRSAQTRRRLASEDGRTAVSGSHASVSETSQSDEGTDDEECL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQB9</accession>
    <name>A0A088RQB9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_191070</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UTP23/FCF1 family. FCF1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698102.1">
        <property type="nucleotide sequence ID" value="XM_010699800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQB9"/>
    <dbReference type="GeneID" id="22574161"/>
    <dbReference type="KEGG" id="lpan:LPMP_191070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190017900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_191070"/>
    <dbReference type="eggNOG" id="KOG3165">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="76105at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09864">
        <property type="entry name" value="PIN_Fcf1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000035">
        <property type="entry name" value="Fcf1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037503">
        <property type="entry name" value="Fcf1_PIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PIN" evidence="6">
        <location>
            <begin position="81"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN97449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="209" mass="24049" checksum="CADC997435EFA796" modified="2014-11-26" version="1">MGKVKRQDNHAIKKILMKEKSLAMKKKREAESYHESPEPNTTKQATKDYAAVLFRKAQVTQAAPMHTAHFLSYNTALGPPYRIWLDTNFINFSMQNKLDIVQGLMDCLLAKVIPCICDCVFAELEKLGKKFRIALKLARDKRFERLTCDSKYADDCVVRTVTQHPIYIVATCDQELKRRLRKVPGVPIMYISKHRYTIERLPEAYGAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQN0</accession>
    <name>A0A088RQN0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Guanine nucleotide-binding protein subunit beta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_210550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698842.1">
        <property type="nucleotide sequence ID" value="XM_010700540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQN0"/>
    <dbReference type="GeneID" id="22574877"/>
    <dbReference type="KEGG" id="lpan:LPMP_210550"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210010000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_210550"/>
    <dbReference type="eggNOG" id="ENOG502S5HX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="63070at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="441" mass="46692" checksum="A0306B50C8E187F4" modified="2014-11-26" version="1">MLRRIAYTLLPRDPQEVRLLHHTGGGVVIAAVSYTKTSSPLFFTVVEMAAPNEQALPLCVVHVRVPRPATVVSAITLMRSADGADVYVIVQAAEKTNTDAAPTSTTSYVYRRQIVADDEQDDYAAEDDVVSSPAASAVPAATRVRYQRLPRAFASAGATTWTAVAVFNPSENMLTDASSSVDPAVTPTAAFITASCDGADNQLQLWQLRGTGVTLEATWRVPALAGFAVQEILTLPGTQDVVLLRHHNSIIEVNLSALRSACAYGSTVTGNTFLSRAWRWSVREQLTACAVKDALLYAGTEGGAVLVWDLRSPTSTATAAGPCGGPPPLCSAALKTPITGLYAPYATGFITCDASGGVRDWRGRGEAGMYENQNEEVEEGALRDVAGMAASSAAASTQFPYRSRAPVEVPTGEEGCVALDGHDNFAAVVSECGRLCFYFCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRG9</accession>
    <name>A0A088RRG9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_231230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699280.1">
        <property type="nucleotide sequence ID" value="XM_010700978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRG9"/>
    <dbReference type="GeneID" id="22575328"/>
    <dbReference type="KEGG" id="lpan:LPMP_231230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230019400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_231230"/>
    <dbReference type="eggNOG" id="ENOG502RC2D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="464" mass="51328" checksum="E2DE017B87C085DE" modified="2014-11-26" version="1">MRYIPYNRRTLTSMRCVSRPFRSAVQSPHSPWAQHKEIMVSRYGQCIIFNAQENEEGHSNFSLYSISSIGRKFRTHSAKLLGRYHALVANGLSRLVLHHAPVENSFFEPLGALTNLRELELVSCRGVTSVGGASRIKGLESLTVVFCPVESDGVTGLRLSKLKKLTLRSCSKLSNLNAIHSETCASLVDVHVESCGVYDDTSSAFFGYLSANLRTLNLTATFIDTALTHIPTAALESLTSLLVPETPFHSSTLNSLKVSLAKKLEHLSLEGCEEITELSALGSLAKLRFLDVSRLSVLQDIECVAQCTELEMFRCAGTDLNSIAFLKNMRHLRVLDATNTALTDYTLIHLEESPELDTVVLTGCLYISSINAFHQCPKIRRILCGRTAVTNEGVEMLTECAALEELDLKMTNVTDVNRLADCPFLKAINVCGSIMMQDAIQRLLDKSSVEVICDSFEENDYMDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRM9</accession>
    <name>A0A088RRM9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amastin-like surface protein-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_241240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699464.1">
        <property type="nucleotide sequence ID" value="XM_010701162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRM9"/>
    <dbReference type="GeneID" id="22575533"/>
    <dbReference type="KEGG" id="lpan:LPMP_241240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240018600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_241240"/>
    <dbReference type="eggNOG" id="ENOG502SMC2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="256081at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009944">
        <property type="entry name" value="Amastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297:SF4">
        <property type="entry name" value="AMASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297">
        <property type="entry name" value="AMASTIN-LIKE SURFACE PROTEIN-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07344">
        <property type="entry name" value="Amastin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="186" mass="20162" checksum="1390CD3BD84B021B" modified="2014-11-26" version="1">MPACLPYYTGAMSFTLLHFLAWAFAFVATPTAQFQTPGHGCYTMWGYRTFCGNVSYDLTGDAAFGCARRTSTMRCGAAFGVMASGCGFAALVFAVLLNTQIQLPVIISFVLAAVCIPFTMISWACVASVYNMVMCGDRFGSKYPYTAGFVLMVASWGLEIIAVSILACTNWTRPPREEVDIAVSKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRR6</accession>
    <name>A0A088RRR6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_241800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699519.1">
        <property type="nucleotide sequence ID" value="XM_010701217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRR6"/>
    <dbReference type="GeneID" id="22575589"/>
    <dbReference type="KEGG" id="lpan:LPMP_241800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240025300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_241800"/>
    <dbReference type="eggNOG" id="ENOG502QVJE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271329at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="244" mass="29077" checksum="454C67AB6578C36F" modified="2014-11-26" version="1">MRPTSLQCSGAAFRLTPVLLPTSSNSSGGGYRFFEDMYPKHDPAPRYSYYEDQMQSPTVRSLEPKKQMTEMEKLHHLHDWKKDKEGLTPPPEFGWPEEWGPEPGEEGHSEWYKKNRMYMSYEEKSRYDLRVGVPVEKNSMRHQEMPYQKRMKAAYVNLEEKNPQYFDPRQRKYWAEYSYEDQRDTMAKARDDYIKEWLDEPGVTKENVAKKIGDYNGTAKHQNVKSVQRRPEWELAPRPEYDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSC0</accession>
    <name>A0A088RSC0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_241530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699492.1">
        <property type="nucleotide sequence ID" value="XM_010701190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSC0"/>
    <dbReference type="GeneID" id="22575562"/>
    <dbReference type="KEGG" id="lpan:LPMP_241530"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240018900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_241530"/>
    <dbReference type="eggNOG" id="ENOG502RKJX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="600" mass="67308" checksum="7ED5F23DA21197DF" modified="2014-11-26" version="1">MTTMARVDETLARFKGKSPRDSYKQICGELHVHMQREIFAALPEKPMAWHHIYTLDLEKSLLGTKGCMAMLPIIAVSTSMRKLSLRSCCLSDDFVIELCAILQNHPSLRSVDISDNELVTVYSASHIIGVMRNNLNMVFFDVYNTHVGANVAGIIAELGQRNLNGVLHYYEDRYFHMKNLFNYMDADGTGWVLLKSLVLNCPYPVLQEQFVERIATKNPRKRSDNTISINTFLQLIYMNYKTESEIGACAQKTIDESYVFTVANWKQLLRAVERYNVCAAAVKDGENSYRPVQLPDDLHRWRLRDYIISNDDADALVEGAVHLMEHSAAMAEDASECRELGERAEPDVEVNRDKDAGEKASEMTPLLISISILLRAAKAALVAPPSAAKPSYHFYTDRDAAYVPEIMRNGSRLFSVGRLSCIFSANASVAGDSVTSADTAQNSTDPPRVFSLPASVVRMVVDFFNKENAKMPAKKASIIPDSPRTRRDKAMEKAAIPVPTFLSTEFVTDLERVCPRLLADYYSRYGLLIEDGTITLQEMVNVLDEMYVQCRIDRVISLSDIEAMSDPLKDKSLAGFMAAHFADRDEDISIVEAFSEVMAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSG5</accession>
    <name>A0A088RSG5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative</fullName>
            <ecNumber evidence="5">4.1.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_252090</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HpcH/HpaI aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.-" evidence="5"/>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699779.1">
        <property type="nucleotide sequence ID" value="XM_010701477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSG5"/>
    <dbReference type="GeneID" id="22575857"/>
    <dbReference type="KEGG" id="lpan:LPMP_252090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250023000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_252090"/>
    <dbReference type="eggNOG" id="ENOG502QR7H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1621678at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050251">
        <property type="entry name" value="HpcH-HpaI_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502">
        <property type="entry name" value="2-KETO-3-DEOXY-L-RHAMNONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="4">
        <location>
            <begin position="18"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN99072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="279" mass="30191" checksum="724672BF4E7D1FC5" modified="2014-11-26" version="1">MSSGGAEFKAELRAGKPKFGIFLNSASPLLAGQFSHSGYDWLLIDAQHSPVDSLTAAHMIAAIHTGHSKAMVRVASTQDRAGIQCALDSGADGVLIPYVNNAQELQDAVSCCYYPTTGTRSVYQPQQCMNAKGLLGYVPESNKNVVIAFQVETAACIENLEEIMAVKGIDIAFLGQNDLCMSMGLYDGRYVFPQMYFSPELQAATDTLISTAKKHNVILGLFLFGTDRVGEFLEKGFTFISIGSELHHAMVQAGTWVKALKDISEEKGKPWTNQPSALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RST9</accession>
    <name>A0A088RST9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPN-loop GTPase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_260480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699869.1">
        <property type="nucleotide sequence ID" value="XM_010701567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RST9"/>
    <dbReference type="GeneID" id="22575951"/>
    <dbReference type="KEGG" id="lpan:LPMP_260480"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260009600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_260480"/>
    <dbReference type="eggNOG" id="KOG1533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF3">
        <property type="entry name" value="GPN-LOOP GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN99162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="334" mass="37211" checksum="C35733D674DFA449" modified="2014-11-26" version="1">MFGELICGPPGSGKTTYCEGKRQFLSVYDPTRPVVVLNLDPANEDIFPYPCDVDIRELVDHATVMEEEGLGPNGTYLFCAAVMQANVDWVITKVEEAVERRIQEVLATEMSAIARGAGAASGGMTLRAPYLLIDCPGQVEFYIDAQVMPTLTRALAKRLQCSLCTVHLVDAGMATRDLPTYVASCVLSLTTMIDHELPHVNVLSKWDTVPAEVLEDTGDDGAAYLNASAMLSENMDRLWRRQLQRRRHEQRMAQHFVTAAQPVPQLTPEERAEDAQLAHLDLAKHLGRVYRYTRLLMDVVEGYGLVGYVPLDVQHQEMMLRLTQEVDNAMGNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RT26</accession>
    <name>A0A088RT26_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">CCR4-Not complex component, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LPMP_251920</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699762.1">
        <property type="nucleotide sequence ID" value="XM_010701460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RT26"/>
    <dbReference type="GeneID" id="22575840"/>
    <dbReference type="KEGG" id="lpan:LPMP_251920"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250021300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_251920"/>
    <dbReference type="eggNOG" id="KOG2150">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="293823at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.1020:FF:000014">
        <property type="entry name" value="Not1_N-terminal_domain_-_CCR4-Not_complex_component/NOT2_/_NOT3_/_NOT5_family_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012270">
        <property type="entry name" value="CCR4-NOT_su3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007207">
        <property type="entry name" value="Not_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04065">
        <property type="entry name" value="Not3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005290">
        <property type="entry name" value="NOT_su_3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-Not complex component Not N-terminal" evidence="13">
        <location>
            <begin position="5"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="14">
        <location>
            <begin position="514"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="367"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="470"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="367"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="417"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="470"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AIN99055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="645" mass="73420" checksum="DE5E509BA2B19671" modified="2014-11-26" version="1">MSNIKKVQTEADRLLKKVNEGLDAYDELHEKLANAPNASAKERLEGDLKRELKKLQRHREAMKTFMQNDDYKEKTKMQVSRKKIEERMETFRAIEREMKTKAFSNEGLASAALERADSATEQWLKDAIEEGRKKIELLEYEVQKANNGRVRRGKQQQQKSEYQIRLENLQTHFFKWESLLRMVNNEELDTDEVDDLQEPIQKVLEDDVELEVMEDMSIYDTFDIPEPKAKSVVPFDVSDYEEKKVQSPKTTTKAKTPMSTVQAKPSPFITSLKEMVASPAAAKASSLTPVSPSILQPMSAQASQQLSHVVSSLADNDNGEEEPVPEWMDDDMDTANDDTFGDEAMTGGGTIGSLAEMASVTNKVVQDWEKPQKPIESPEPRTVKVSDTGHATLGERPKLTLPAAAPTPNAWERRAAEQQSRQKAQQQQQQQQQQKNASNAALPVTPSWPSAAAAEASELEAVATPLVAPAATSPSTPASSTHTDPIQSFPPIPGAAPGSKFTPKKIHELLDMSLGNLPHTLDVQRQRPYEPPNAIDAISYFPQEVLPVLSSKDVYHHMDLDTLFFIFYYHQKSYQQYFAAKELKARSYRYHTKQQRWYQRLERPQTTTETEERGSYTFFDFEEKWDHDRIDDFLFEYKYLENELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RT79</accession>
    <name>A0A088RT79_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Adenylate kinase, putative</fullName>
            <ecNumber evidence="6">2.7.4.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_252470</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the adenylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6"/>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699817.1">
        <property type="nucleotide sequence ID" value="XM_010701515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RT79"/>
    <dbReference type="GeneID" id="22575895"/>
    <dbReference type="KEGG" id="lpan:LPMP_252470"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250026800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_252470"/>
    <dbReference type="eggNOG" id="KOG3078">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="5">
        <location>
            <begin position="133"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN99110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="234" mass="25442" checksum="5B58BF6A17C080DA" modified="2014-11-26" version="1">MPSKFLRLLFTGAPGVGKGTYSSRAAASLGCHVVSSGDLLRKEVAEGTAIGKQVKDLIEKGVFVPDELIAKMMVQHIASLSADKECPSGYILDGYPRNISQAEALWSSGDIKIDHVINLTQPRNVIIKKLSSRRSCPDCGFVYNLASIDEGGIKMDPLKPKVDGVCDKCGCTKPLITRKDDEIEVVTKRQDEYSAVAMPLLRFYKEKGVLHEFPVLGGTTVYLPMLLELISALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTL2</accession>
    <name>A0A088RTL2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RPGR-interacting protein 1 first C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_231390</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RPGRIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699296.1">
        <property type="nucleotide sequence ID" value="XM_010700994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTL2"/>
    <dbReference type="GeneID" id="22575344"/>
    <dbReference type="KEGG" id="lpan:LPMP_231390"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230021700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_231390"/>
    <dbReference type="eggNOG" id="ENOG502R9GT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272770at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021656">
        <property type="entry name" value="C2-C2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031139">
        <property type="entry name" value="RPGRIP1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14240:SF1">
        <property type="entry name" value="PROTEIN FANTOM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14240">
        <property type="entry name" value="RETINITIS PIGMENTOSA GTPASE REGULATOR-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11618">
        <property type="entry name" value="C2-C2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RPGR-interacting protein 1 first C2" evidence="8">
        <location>
            <begin position="507"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="753"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="832"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="168"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="833"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN98589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1132" mass="124548" checksum="86ADA6CD5AB86DA8" modified="2014-11-26" version="1">MVWGTDGHSSMQNYVVASALYHANEELRRKLNEAATALQTLQQDLASSRTQHAAVQTRLENVSVQLHQLVRERDLSTQKYTNASRTIVDLERTLRERISEEEKVRFSLESQITELRSRLVVGADSNELLQKDVRSLLSETRDRTAEVMSLRSNLALTESALSSQKHVNENMLVELKSLNSQLVEERKRLITVTREAQLASLSGARVDDLEKQLQRVQEERSAIEREHVGLMSEFVHITEDALRHAREEVARDVADWKAAAAHWEQVSHLLYKDIAERTQHHLRCRAECEEAQGQRDAAELQVRSLKREVALLIAKLDVVWPTHATDAKGLTAEEILNVFGRNDRAGIFLFDDRRRRRAAALRRSGAKGVDATGGSAAEETTGAVEEDLGGGEEDAGFDLAAAVLSDLPADPTTVACQLQELHEANATLISEVHQLRLTNDLLQDRLDGLMGRQREDQVRMTAAEVSLQQREKAGHQLLEKQLDRVAFLEAQVKSLRGYHVPANAPIGEVGENENIFELFLGQLVAAEVPEGIEVPEMFSTMFCSADFLVHETITTGTVRGFNGFFEVTASFRVSMDALLFYYLHTRQLLLQLHRVRDADEAAAMTVAETTGAGAEDAHFSANAVAETGTTHSAHSGSTDPSLRIAEHMFETIAEGQVSLADIVLREDCRHSARPTLKGHVRLVTPAGRHLASVEFRLTARRPYSADFLRLVEKSVAATGTEGAAPNISKEADSQDGMSSHLLDWMRATANTSLDAASHQRQESGEDTTLTPRHTRRTAMTTTPTHSYHRARQNQLQLVPVVSADGDTSSTTSSFLIQQQSRMAGTAGAMVVHLPPPSPPPLQRRPRASSWDGREESDLQAARHGGGASSLSSRADRDSVMERSPISGSFMHVNRSLLSTRPVAGGIGGEGSSVTGGAIQSLWVDVERLELPADLPPPIPRLSCYFRVEVADLEVWLDAPPTPRYTWEYTLDVRDSRAGAYGVSVPVRSVTQLAAVLREPLVVFLLDADAMASTSAAAATDPCVWAMVVCEWGQVVQRPNEPQSFALPLLRRDQSVVHGGVLRLSLTASTIGVHSIPSRAASLPSQLHATVVNTSTLPLTPPPPMSPPQPMDRSMEEELLRLEYKHHTGRSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTV8</accession>
    <name>A0A088RTV8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Putative rRNA methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2'-O-ribose RNA methyltransferase SPB1 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_271980</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Probable methyltransferase involved in the maturation of rRNA and in the biogenesis of ribosomal subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a ribonucleotide in rRNA + S-adenosyl-L-methionine = a 2'-O-methylribonucleotide in rRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48628"/>
            <dbReference type="Rhea" id="RHEA-COMP:12164"/>
            <dbReference type="Rhea" id="RHEA-COMP:12165"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90675"/>
            <dbReference type="ChEBI" id="CHEBI:90676"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700284.1">
        <property type="nucleotide sequence ID" value="XM_010701982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTV8"/>
    <dbReference type="GeneID" id="22576376"/>
    <dbReference type="KEGG" id="lpan:LPMP_271980"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270028100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_271980"/>
    <dbReference type="eggNOG" id="KOG1098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1287559at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000004">
        <property type="entry name" value="AdoMet-dependent rRNA methyltransferase SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03163">
        <property type="entry name" value="RNA_methyltr_E_SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012920">
        <property type="entry name" value="rRNA_MeTfrase_SPB1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024576">
        <property type="entry name" value="rRNA_MeTfrase_Spb1_DUF3381"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028589">
        <property type="entry name" value="SPB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF13">
        <property type="entry name" value="PRE-RRNA 2'-O-RIBOSE RNA METHYLTRANSFERASE FTSJ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11861">
        <property type="entry name" value="DUF3381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07780">
        <property type="entry name" value="Spb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="13" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 8 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 8" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="10">
        <location>
            <begin position="25"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3381" evidence="12">
        <location>
            <begin position="237"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA methyltransferase SPB1-like C-terminal" evidence="11">
        <location>
            <begin position="735"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="329"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="512"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="569"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="443"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="593"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="669"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="696"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="717"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF11861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIN99577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="927" mass="105398" checksum="578B4CFDBFED3E46" modified="2014-11-26" version="1">MGVKSKKKAKTRLDAYYRLAKDQGYRARSAYKLIQLNRKYDFLAKSRVLVDLCAAPGGWCQVAAQHMPIGSKIVGVDLVPIAPIRGVKTFVGDIVDDKTRKMIVTYLKKEPVDCVIHDGAPNVGGVWSRDLFDQNALVLASAKMACSMLKASGWFVTKVFRSPDFHNLLWVFKQLFDKVEATKPQASRMESAEIFVVCAGFKAPKNIDPAFFNPQKVFAEVGEEKIVSASGLLVTPKSDVPIGYDEFATVSHRVASFSDFLRADDPKGFLKIHHELRFSDDVDKAYLKSKSSKKELVYLCGDLQQVGEADLRRMLRWREQLLREQARHIQADAVGTEEDGDADSMVGGTGSDGYDDGDDEDDGQRKRDYYFDFDSPEGVTQIARELLEIRKKKAKELKKKQKKVVDRKLKQIKGLINYDPNMSAEHMTEADGFDYQGTHTDAFDDDGDTAAGDEDGKPDELDHFTVEQLGLIPEKELARIMDTTWTGPEDCGNDPLNPVMSVNLAAQDDWDLGEKENSDGSEAEGADDGMPHSKQLVEGEEYFMDVDNYGNYVPAQRSTRVTLYEAGLEGHEDSNDAEAADETPASKKKRVKAEKDAAQLEEAGKSSKWQRHQLNIEKVLNDTFPKPKDHNRAKNKKRQRVLEEERITMNAPTEMADPDKRKHVRTRFEDDDNDDSDASASELSEELSDGDLDDYEINRGREDSRRKRKLVPDIGKATTQELVRQQRKQALQDNKEVRKQNKRNKNNTNSGKHVSGKEDTEFEEIPIAMTDPDIRARTLAIAQKMLDPKARRDILDASVNRYVFNDDDDLPDWFVKDEQRNCRVVLPVTAEEIEEQRRRFQELNARPSRKVMEAMGRKRRKAQRMLRGLIDKGKADPRAREKAGNLSVRKLMRSQVVKGQGKKKHKYLDRQLMGRMRREKQKLKRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTY9</accession>
    <name>A0A088RTY9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_240540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699396.1">
        <property type="nucleotide sequence ID" value="XM_010701094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTY9"/>
    <dbReference type="GeneID" id="22575463"/>
    <dbReference type="KEGG" id="lpan:LPMP_240540"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240011300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_240540"/>
    <dbReference type="eggNOG" id="ENOG502SSWK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="263282at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="88" mass="9907" checksum="8A3938F684FEBB4D" modified="2014-11-26" version="1">MNIDLFLLFEAVTISIFGVVLFAIIITSISACLQREHRMKERGQQCEELVVMTTEKQQQLQWLSGINNLTDSPNLCGDAVSLSYLSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RU15</accession>
    <name>A0A088RU15_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Anaphase-promoting complex subunit 4 WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_240910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699431.1">
        <property type="nucleotide sequence ID" value="XM_010701129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RU15"/>
    <dbReference type="GeneID" id="22575500"/>
    <dbReference type="KEGG" id="lpan:LPMP_240910"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240015100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_240910"/>
    <dbReference type="eggNOG" id="ENOG502S6I8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273477at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="664"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="546"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="944" mass="100223" checksum="C73C9E403A488E74" modified="2014-11-26" version="1">MKLLHSKSTAEPILAVTACPCANLFGLVTRSSAAVYRSTTLTTVFNFSLKPFQSALRDNAADEERRNDTSVCCCWSPSGRLFTLAMPSGLLLVLDVEGGALVRFLTPGATAPVSSDGASGSSSTPASTSVPRVPTTLPPGRPVLAMGWCAVPSLFSRHVNAMHVDMQTRCLPVRTGVTTALLDEVAQGSSISLFGAGDASHLLFSTAATSGRYPADAKRASRSISLLMVLGCDGVLRCLIGGLYEVQRLELSLPSCYPTLPVSGLRGNVAAWEDVVVEDMQVRHCTVSTGASAGSRTHPQRETGLPGWMCFGESVVSCVRPAVAQQHRLYLTVAGALSSGAAAPAVWEVNLHANLSALAAPHWLALCYVREYTRIAREVYEKAAREWHAVLRRRLWAHLGLPAVAPLLSSAILAQLTEPDPLELYKYAKQQLMHAAVTEDLEVMATAVQRAIDDVTHVCYRCCEAAMACTVYLREADTVTQHLGTLRRLCESFLRRVTREAESARDLALWVLQQSHYWSRSSRFAMGPADERAPVGAEEDQRERLSAVSSPSAAVAATTEMTHSPSPQQPPSVVDEVPLSATRQPTLLSYLSSVTSQETNVEDDPVVCICEQLAISLQDCASLPASAMAPLPACIVLSNVQESGATSASPASQFLCCVVKGTEEGERGSRDGRDDNEDIIDTSVTVNGGDGYGNDDGMANGYYPRYETGLEDVALGEGTRDVACGECGCALVTEGVDIHVLRCAATAANTIRPLQIGTYKVVVHRDGDAGDDCADSSAASGAVLEAGPTVDVDITLITSRLKVDLSSSHSYAAPSVIYGATWYGYLEADRHVVVCQPNSITTDRSAGSGAQSRSAAPAPFFVAVVDGSGRLVTVDEEERDDGDNEDGGDAADSSAAALSTEAALCEVTGMEGVPLRVSMSRARSFCVVASVTKYIVLSLYDDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RU85</accession>
    <name>A0A088RU85_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_241920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699531.1">
        <property type="nucleotide sequence ID" value="XM_010701229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RU85"/>
    <dbReference type="GeneID" id="22575601"/>
    <dbReference type="KEGG" id="lpan:LPMP_241920"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240026500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_241920"/>
    <dbReference type="eggNOG" id="ENOG502S0JW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="250638at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="365" mass="39527" checksum="1711F5514FC1982C" modified="2014-11-26" version="1">MPWWSGEPVGGKAGAVPADAQTTQDVLAAIFAPANCAMASPRASVDGNDVRSTALSSSAVDTVSAKGRSSAAPPEETTLSILISTQGGVDASESPATWWTSLRKWRPSTSIPCSAGASAPELVLSSTTTSRSPKRTAENVDKAAASVAKATAAVSWETFPNCPLAGYELTRQGLVDRLTKPPHTLTAMELRSLIKELTAVEQQAKYDVDRQFGSHISSRGLHGLELVISPALFLTSIYLMTWKAARLYHNALPQNSVLFTRVLALLRLRMAVEQRELVAQRHRRLMRATNARVSLSFLSGVGLFALAWVSRPPANVMEEAPDVQGAKELIAYQRHFQTSLKWCWYVYYHHPAYSTSGGSDKSSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RU98</accession>
    <name>A0A088RU98_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_242070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699546.1">
        <property type="nucleotide sequence ID" value="XM_010701244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RU98"/>
    <dbReference type="GeneID" id="22575616"/>
    <dbReference type="KEGG" id="lpan:LPMP_242070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240028000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_242070"/>
    <dbReference type="eggNOG" id="ENOG502S20R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271969at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="303" mass="33510" checksum="1E4A6384C9A6CF16" modified="2014-11-26" version="1">MLSAAAAAAASPRPPSSALYTERLFYAALKQGNPSEARVEALAALALRHLPRSAETWAALRKALMEQSDLDGAPNRALWYVLDALMKHAPHVFVPLLAPRLLEYTIQQLPWELAGHRGQTLLWFEALVLSWEKVLPQRLYSAVRQHAVQSRSGAELHDLLKATQNSVDDGTSASSVDLQQLRDAWDAVQYMGEQEAGKSVFHARHTTTAVEVVDEDANKSSSFSAPVSRLHAMSIGNSDRTAGAGASGDDVTKTQQQQEEEEDDYTPDFVEGAKPRELPKLDLPKQRRRREGRRRPRADDLGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUN1</accession>
    <name>A0A088RUN1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome c oxidase VII, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_251160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699686.1">
        <property type="nucleotide sequence ID" value="XM_010701384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUN1"/>
    <dbReference type="GeneID" id="22575764"/>
    <dbReference type="KEGG" id="lpan:LPMP_251160"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000019400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_251160"/>
    <dbReference type="eggNOG" id="ENOG502RYJW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268402at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="165" mass="19200" checksum="3F2A5B72DB8161C6" modified="2014-11-26" version="1">MPRPFGVWAPATTLAEYRARIPNPFAYSFRWIYSMKREVFYPPEALAHFKDPQQFKDAVDTIIAMRVSDKIFGEGQKLPRHPVILMLVVMATHSFIIFSALKYYYGTYMPANNPTWRKTVNKEWEEAINNSPWDHMSHVWQYSDEYAAALGDTAAPGQRKFYIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVT0</accession>
    <name>A0A088RVT0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">6-phosphogluconolactonase</fullName>
            <shortName evidence="2">6PGL</shortName>
            <ecNumber evidence="2">3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_262670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="2"/>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700086.1">
        <property type="nucleotide sequence ID" value="XM_010701784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVT0"/>
    <dbReference type="GeneID" id="22576170"/>
    <dbReference type="KEGG" id="lpan:LPMP_262670"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260031600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_262670"/>
    <dbReference type="eggNOG" id="KOG3147">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="432544at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000027">
        <property type="entry name" value="6-phosphogluconolactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="6PGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054:SF0">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="3">
        <location>
            <begin position="15"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN99379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="267" mass="28641" checksum="B42261F65831C3C6" modified="2014-11-26" version="1">MTSFAPTVKICENLSQMSFAAREVILAAIDARVDKSVPVVLALSGGSTPKRLYEELHEKDLALLQQHAVQFILGDERLLSEDDEQSNFSMATKALLRDVPSSDVISIDRRAALATSKDEKGGLDGAWAVAQDYEVKLLNCLPCKQINGTAKSVPVVDIVLLGFGSDGHTASIFPDSVAATDEEHVVSVSFPSPTMSPKVWRVTLSKTVIQYAKHVVVLAAGKDKNWVVRGVLSESPTDPLPVSRFLRDCRGSVTLLLDPGAGEGVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWK8</accession>
    <name>A0A088RWK8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_303260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701348.1">
        <property type="nucleotide sequence ID" value="XM_010703046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWK8"/>
    <dbReference type="GeneID" id="22577379"/>
    <dbReference type="KEGG" id="lpan:LPMP_303260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300037500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_303260"/>
    <dbReference type="eggNOG" id="ENOG502RMB0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="248175at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33667:SF7">
        <property type="entry name" value="RIKEN CDNA 1810020O05 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33667">
        <property type="entry name" value="SI:DKEY-57N24.6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="976"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1017"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="507"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1026"/>
            <end position="1036"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1036" mass="111478" checksum="E1DC8C55FE05D2E8" modified="2014-11-26" version="1">MPKKEKAKKALTSAVTPPGFTEEERLLEVQLHWDVDVQAAPEVLVFLRLFQQDHFILPHQLLIDSNSDADADGQHQPLQQQLSAAPPLLPLVKQTVPVSMPTARHILLNDIKANRVDVYTLPGVDDVNEAGDKQTGSVAGKRHKGAATAAPKSKVKATAGLTTLPDGARHIGGTALSLVPLLTSSTMDVAVALTAGSLAVANDYLNFRVQCRDLLLSAQCMSQCRPVLVRLYGVVGLPTVASTSDPSSTKYMAAAATANSRRRLRACVSLAGGRVTVPVLPIRPAISAEEAAAPPLFPPRSPTATFHDHVLFLNELGTPLDVYRKLYSTLCEVSLWQSFEMDAQGTAVEAVGASALPGGCTEVLLGSGSFLVRDFLTDDQTRFCETVQLLPGRTTVDLAKDCTCLTTGCSVSVHLDFFQPFPPLRHVDKEGQPLPRKAFLTRALVHLPYAAPWMADFLTLLLREVTALPPATQDVQLYLPPPPLPTEAMEKEKAVGRRRSAMHGRGAAAPTASASSRRPRSDRRSHKAGKSIGCPAPPDLMPASPSPSFADELKVYSPPGLSGFEVADGEERLWCFEATVLEVQHILSQLGSFVEAHGGAPSRVRLHFNAELFVPQRAYMKFPPLVVPPAGMAVLSSPSEVDGSSVALEVDPSGTGGRLHRIRFRSTVGSLCRTQSHYIRHNLSDDCLQCLLSLAALLGAGSMREAELRGWMPSATLLIAAERSFGQTLEKEDLLGVALTTPDASQTAVTALVPKDDTADGAPERSASSAAASLMAGVAVGSLVFFDGILKTGTRRPVPATVRLRFPVSAWMVVTKTKEEVLCAFPHNSPTGLVQYHIEGQVVRCSTTTLLYVLKCVCLARSVTQNYNAAYEHLLRQRQREQRALLLERSASSATGKCVLARQAAADVAGGSRGALDCSVDKTRVSAAGQVCGVDSSDGDDDGEANWLDSGMDRYLYVSFGSSNKSTTLSRRLQMDRASSHRSLVPVTQRRQAPRAVSSPTELTYDELWRMYERRAPTSATAASARDPEKLPPIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWR5</accession>
    <name>A0A088RWR5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_302510</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701274.1">
        <property type="nucleotide sequence ID" value="XM_010702972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWR5"/>
    <dbReference type="GeneID" id="22577304"/>
    <dbReference type="KEGG" id="lpan:LPMP_302510"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300029800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_302510"/>
    <dbReference type="eggNOG" id="ENOG502S3BT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2122564at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008914">
        <property type="term" value="F:leucyl-tRNA--protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.70">
        <property type="entry name" value="Leucyl/phenylalanyl-tRNA-protein transferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004616">
        <property type="entry name" value="Leu/Phe-tRNA_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042203">
        <property type="entry name" value="Leu/Phe-tRNA_Trfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30098">
        <property type="entry name" value="LEUCYL/PHENYLALANYL-TRNA--PROTEIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30098:SF7">
        <property type="entry name" value="LEUCYL_PHENYLALANYL-TRNA PROTEIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="242"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="256"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO00474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="490" mass="54149" checksum="79D18A01F8C6E3A6" modified="2014-11-26" version="1">MLSRTPAGVANDGNAPVNTTLLPVLLGCGLNWASFVASHPFEVKGLTSALVVGGGGDRKGTGEQNALVLAQLPVASVVTSRAVLERTFTKSMVHPLASPDVMRRVEHIATVWCLHPSLVYTATLSWSTEGSESVSTTTVELKVQTEDWCAPLDLRAVVLHVLDHGSLLFHPEFTRCILAQGAERFMFYLPPNPLEATTALPFMLEMWYNGLFSLPESLRLGPQHTAVFFLLANGNTRYTLDLAPESPTAPVTSSTHQHDTGTSEPATHRETTVPLYPWRCQSKVRRIIRSGAYAVVVHDDPAGVMECLQRAYSYHGHNKRSTWLNDVFISLMGQCSTRSMASSTDAAASQAAESDKPHSVRLLCIELLEKATGEVMAGCCGIAVGRAYHDYTMYTLRRSKESLGTFLTKLIGEALQQCGYTFWYWGFCVEYMQQYERHFGAVEMPRDVFYRRWGAARDAVPELTIAAYLQSHRGMVPYYEKTSTLAHSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWY3</accession>
    <name>A0A088RWY3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_281260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99759.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700466.1">
        <property type="nucleotide sequence ID" value="XM_010702164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWY3"/>
    <dbReference type="GeneID" id="22576571"/>
    <dbReference type="KEGG" id="lpan:LPMP_281260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_281260"/>
    <dbReference type="eggNOG" id="ENOG502SC3Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99759.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="142" mass="16075" checksum="B04886C3D1187416" modified="2026-01-28" version="2">MSEPCVFKGCPSVALVVLPKCEYCEQRYCTSHMLPERHGCGDACKNAARRQATADAAAQRRARRHLGNEDAKKRLDKKLGASEAARRKKTKSTHPPPTKKNELTCVETHEEAETASLGLESDDSQQRRKRETRDVRYRRLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWZ0</accession>
    <name>A0A088RWZ0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translin-associated factor X-interacting protein 1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_302480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701271.1">
        <property type="nucleotide sequence ID" value="XM_010702969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWZ0"/>
    <dbReference type="GeneID" id="22577301"/>
    <dbReference type="KEGG" id="lpan:LPMP_302480"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300029500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_302480"/>
    <dbReference type="eggNOG" id="ENOG502RUCC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="242093at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="330"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO00471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1082" mass="117332" checksum="585C54AD1E88F0B2" modified="2014-11-26" version="1">MSGGGDVCSGTVAVCGLQYTTSPSLPSAVKAARDIMLTSSSTFPSIPGVRGSCTTGATAHSTASTRLDPFPQSTLQLYHSYYGSLRGTEPAMLATNGGGRSAEWAGSLTLPDDLSGIGPSARRLLQLDAAHQHQQRAKKGESKKTPGAPAVLPVASRSLPTQLGRSRAVATDSATAAAFSSMAPLPVSAQKFMSGTQNAVHASTATSHHWEHTIAARPLMLSSNITNRVHGGGGGGTSTIPAAAAPPPLVTQLQCYIKREIVLNSGGAAIPSAMNQLSPYREAFRALSSAFPAYASLLNDIQCAYDNAIQAQAELLTDAYSAAAERHVERMTYQEKAAALHQQVSTLQAELSEMAKTLESRAHVEGEQQQVTMQKSRTSRTTDALELRRELEAANERVSQLTHSSQIDLEKILVLIGAVRECDRRLKDYERLVTSVMGQVSELDEFKRIAGEAQTELQQFRNKYSDYVPAADFYLTREYLAGELKAAQLTTRRWRRTAAVRGTQLEVMQGRLSTLEEDRESLVKALAVATAMPSGGEAHASSTETVLTPRPSWKRLYEQYPELAGYAADVGHLTTELDRDDDDVDGVANEDHSAARRTSTTSIFALDLPTVKGPKETRLQVKYLVQRIVTLEGLLRTQRPEQPLRHPSRAEVVEDGHASMDTARANSEKASQEVSLATKDKAVDPSAMLQHRNSRRHHSVGDPFHNTASAAIDGAAVPRLAPPLELPLLGLGYGMQIPLCWRASGVLPRRPVAPSTILSLVYHFFFDVLPTYLDQEDKVQQTLDSDGTPVQGGTDDLALLLYELLQSEMQIHEDLQAYDSVAHLMMNLERDGEKWEWFSDALHLFLWIANGVMPPRIGVDAAVVVAQVKRDIRALAKELQTSRVRRQALSECLQPVLELKTAAEIAELRAALGGEATFNANVLCSDTHLFMQVLLVQECRAGMDLYVSFLRALTVRANLMTRSDSRAATAGSVAAAPKGARGFKAPSMAQLAEGDRVLSLEDVSAAILEVEPRTPEVMLRELSLNAVGSALSVPTLGDTIASKTDVSEEPSVVVRLSDMERAIRVAPLIRHTVRSSKEDWVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXK1</accession>
    <name>A0A088RXK1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_320030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO00893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701693.1">
        <property type="nucleotide sequence ID" value="XM_010703391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXK1"/>
    <dbReference type="GeneID" id="22577744"/>
    <dbReference type="KEGG" id="lpan:LPMP_320030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320005300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_320030"/>
    <dbReference type="eggNOG" id="ENOG502SICJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="259587at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="256"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO00893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="367" mass="40924" checksum="45203BFC036E0B27" modified="2014-11-26" version="1">MQDQSYVKPGFSARGAGIGQAYFTRDLFTDVPTIIQIVPVSSEALTTQRDPPKGNLDTFTISLDDVEPTAGWLSDRNNASLDICFMHSFGKCYGKVRYKDPRTCHQIHVRREVLDNLRKYYRNPQRNYFSRTMKANVTEKFAQVLSLLARRRVALQYLEFRTEDIEVTAGSTEYEVQYRLWLVSDVDPQRTSMAKAANILTDNFISLSNLCWDFALTGRCSRGAACPDLHGRVAKALTKDRFVRAALTEMGKNDTLAAAGETLPPAKTSKIRRSSPGAPRHLPPPPQVPQQCVTYMMPSSAMPAYHFSSLPTMSEMSASFAKPMFTAFSLDMSSLQGLPWLFVGESNDSVFPLTTPSPCVPFGSDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXQ9</accession>
    <name>A0A088RXQ9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_311880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701579.1">
        <property type="nucleotide sequence ID" value="XM_010703277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXQ9"/>
    <dbReference type="GeneID" id="22577614"/>
    <dbReference type="KEGG" id="lpan:LPMP_311880"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310025700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_311880"/>
    <dbReference type="eggNOG" id="KOG1471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1434354at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF1">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="165"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="506" mass="56690" checksum="4576072C3AC62212" modified="2014-11-26" version="1">MEAFAEDGSATGFRPQSGTCTLTREQVEKIEALIHLMKEHYDPLPAQLEMYLQLIPPPASVASAEEDSGNKAQPRNLVRNLMRSYCSSFLVSREWDVQKAFSMMQDVVAYRAANRLDEQCFFPPAISVHGWSTVEVCRALRQSPRETALRVDRVCAGVTQGITCGIHYWDKGGRPVAYVMIESLDVVELMRQLRQMASVGKSPADVMWEYMVHLLGVTESAMLYQLIQREARRSGRSSTSKFTDEATPAEVTQGAVTMIYDMKGLSVKMLWKPILDLFRDLAKEFFKYYPDRVHQIICVNSPSLVRYAFRLVRGVMPADFQNKISFFSSHDTLATLEKVIDRKYIPHFLGGDCHCTAEGGECLSGYDPLHPRRAAVTDAHADGDGEVCTEDVTLTTSQACTRVFPVKASEVVVWDFAVAGGGHDIIFTVFFVPQSATSGMRWSEVEVKKLSPYTVTSEALPEGSDLFVAAEDGVVVLGWRNRRSWFAAKRIQLRAYKEAMSTTLHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXT2</accession>
    <name>A0A088RXT2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Carnitine O-acetyltransferase, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LPMP_291350</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(R)-carnitine + acetyl-CoA = O-acetyl-(R)-carnitine + CoA</text>
            <dbReference type="Rhea" id="RHEA:21136"/>
            <dbReference type="ChEBI" id="CHEBI:16347"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57589"/>
            <dbReference type="EC" id="2.3.1.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700742.1">
        <property type="nucleotide sequence ID" value="XM_010702440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXT2"/>
    <dbReference type="GeneID" id="22576899"/>
    <dbReference type="KEGG" id="lpan:LPMP_291350"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290017800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_291350"/>
    <dbReference type="eggNOG" id="KOG3719">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004092">
        <property type="term" value="F:carnitine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004095">
        <property type="term" value="F:carnitine O-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.70:FF:000007">
        <property type="entry name" value="Carnitine O-acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF60">
        <property type="entry name" value="O-PALMITOYLTRANSFERASE II, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00439">
        <property type="entry name" value="ACYLTRANSF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="17">
        <location>
            <begin position="19"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00053195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00073438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AIO00085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="627" mass="68266" checksum="7B2ED598FDA76207" modified="2014-11-26" version="1">MKRISATELHGNVLKLPRLPIPSVVATMDGYRSSLRALWSPEVTAPHLAKLDAFLNSSAPVLQRHLVDADKAAAESGKAPFTYVEGLLAQSALNSRFPQEVNMNAAFVLQPGIPGADRTQAGVASALTYGIACWIHELRTNGLSVSADPAARFDVSPLLTEFGRSLIPSKETDLLHTTPLEKLRHIVVLHDGHPYMVRVFDEHQCVLDRKLIQKAFELILTITPDQDNTSPVSVLTAGSRTVWGQAYQELLRTPENAEVLRLFHESILVVCLDSTKWGSDESLAEASALHGSKEELENRWYDKHQMIVSEDGQVAFNFDATASDRVHWAKWVSDVLSILKERGSGGLSTEGIDGAAVSGIVRHLSVTYGKSFVSHIRAARQEALAIVADTEVHSIHIPYGKAQLSALKVEPDAFVQMCLQLAMHKMRNKLCCTTEVCSTAGFFHGTTELVHTTSEEMLELAKHLSQYQQDGEAAAVLDTNSKETIAKLIHATGDRHVALTAAASRGEGYDRHLMALRHVARINGDKAALAFFEDGMFLKTSTSVLSTSEFSQPWLRYYTFGPMQSSGYGLGYVIDEQEVRVSLSAFTNSPTTNVADLKAALLLSCNTLFEVLGGVPAAKPATAGGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXU7</accession>
    <name>A0A088RXU7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome c oxidase VIII (COX VIII), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_311500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701541.1">
        <property type="nucleotide sequence ID" value="XM_010703239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXU7"/>
    <dbReference type="GeneID" id="22577576"/>
    <dbReference type="KEGG" id="lpan:LPMP_311500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310021100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_311500"/>
    <dbReference type="eggNOG" id="ENOG502RYMM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268443at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="157" mass="18802" checksum="D5D46B2B40DC9B89" modified="2014-11-26" version="1">MLRRTVPAVSFTASHRALMMRPSRPLLGGDMHSTDRFKAAWDEIPLHMLGASHKQMFEWYWRAMYQLGLRDPYRFTKLRSMINWAGFFSFLYLTYISVFYSSFYHVYMMDWPEHFKRENAREYALSHGHDVWAGDGKFIRPYFHINPPMLTMTAEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXW6</accession>
    <name>A0A088RXW6_LEIPA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_321220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701808.1">
        <property type="nucleotide sequence ID" value="XM_010703506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXW6"/>
    <dbReference type="GeneID" id="22577863"/>
    <dbReference type="KEGG" id="lpan:LPMP_321220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320017500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_321220"/>
    <dbReference type="eggNOG" id="ENOG502S0UG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="251039at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="305" mass="34001" checksum="35C560C334BBB310" modified="2014-11-26" version="1">MDASAQHHSLELDQVTCPHYYHCVLHDVSFQLPVREIAARLVPNKDSDLVQRLAGAGCRIVPHQLHMYKEPLEKKFGYVSFFIRQEPHSTTDADYVHRLVCEWIAVDLASQLATTQCKVQLSQPPECHSSESFLNTFRRRCPLLDPKLVSDPMKLETFILTRVRFAQHRGNVSINELNAMHCDSAKVATSVDHRGTETGSSMSVGLTGTESETDSGVHSATRTRDEHVWKCVGTFSIAALSSKELVWLKKQLPSFPPLLITNGDVNTTHCDEVKLAQFFEASLTPLFTVEKVKGEAGVAIVCSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZ05</accession>
    <name>A0A088RZ05_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_330950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702188.1">
        <property type="nucleotide sequence ID" value="XM_010703886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZ05"/>
    <dbReference type="GeneID" id="22578248"/>
    <dbReference type="KEGG" id="lpan:LPMP_330950"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330014100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_330950"/>
    <dbReference type="eggNOG" id="ENOG502S715">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268920at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO01388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="117" mass="13141" checksum="4DA8BDA05051CCE3" modified="2014-11-26" version="1">MYLAVFHEFAHPEVLEKVKSEGICDVDVAPEPNKLAVSEEEQQVVRCNAKLITVKHNITGIRDAFDGMTEGELEKNDNQVDQKLQQLVALGFQVVERHPKTSAGRPMLDRVILSYPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZE2</accession>
    <name>A0A088RZE2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_330180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IWR1/SLC7A6OS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702111.1">
        <property type="nucleotide sequence ID" value="XM_010703809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZE2"/>
    <dbReference type="GeneID" id="22578171"/>
    <dbReference type="KEGG" id="lpan:LPMP_330180"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330006600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_330180"/>
    <dbReference type="eggNOG" id="ENOG502SDJH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273137at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013883">
        <property type="entry name" value="TF_Iwr1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08574">
        <property type="entry name" value="Iwr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor Iwr1" evidence="3">
        <location>
            <begin position="172"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="225"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO01311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="279" mass="30937" checksum="2374E4890CE2BF97" modified="2014-11-26" version="1">MGTPPPILQAALSSRTKFVFRRLHQIDAERSSRMATRLVPHGATKRHTRLSHSQVERLTVAGQCVVIECGDDVSGADDGAGTVELFVLDSRATERDAMMEAFGEFTIMEDELTGCSQSSLKHGRGEEDEDLPCYFLGPLRRTSSVGDHSTAAEDSVLASPSRWGAVKADEDGTMRRFLQEYDEMLCMEATGDATADLYCYPDHRKDDEYDSNAEDFSGNDYPDEADGRSGESTRRTDEEASNSSTRRQRVYVTSRNTYGISCEEEYSERSLSSGWGSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZL7</accession>
    <name>A0A088RZL7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside triphosphate hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_333030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702393.1">
        <property type="nucleotide sequence ID" value="XM_010704091.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22578456"/>
    <dbReference type="KEGG" id="lpan:LPMP_333030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330038200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_333030"/>
    <dbReference type="eggNOG" id="ENOG502REWB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273353at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35615:SF6">
        <property type="entry name" value="KINESIN MOTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35615">
        <property type="entry name" value="PRESENT IN THE OUTER MITOCHONDRIAL MEMBRANE PROTEOME 22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="835"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="912"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="965"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1537"/>
            <end position="1599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1818"/>
            <end position="1891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2307"/>
            <end position="2343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="912"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="971"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1566"/>
            <end position="1585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2307"/>
            <end position="2316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2750" mass="290738" checksum="FB986B0EC3CECEB5" modified="2014-11-26" version="1">MMANGDYTYINDLDDGGPMSTTLRLHEQSSSLFVGITHDSAGESQSQYDYLDGSLAGSNSGGGDGIVAALALEDFLGVDGSNLTSVLSESNSVFDIDAEENNTQTQTPSVASRSVSGADFNMLPMAPTAKQPIEKPPGASASAPHPAVPNSAVLARHLNLRINTVIDLKRPSTLYKYYEIFGGASSPAGGHNHKANFSIGASGSDAHHRNAKDTSTHRVTNATVTAAGKGVMATDHTSKLSALLPETAAVSVPTRPAVPPAPSPLHPLPSVAQPHNGSEVFSFGIDTFLHGNQLGFGRQPSFKRLTPVTQGESRRPYFLLRCKDGDTSSTTTAGAAAAAVRNGHPAASASSTRVRAASVADRSAEAFSTWLEALESKATGLSTSARSGPGATHVGSTIGENFKREVDVLMKSLFGDYDVFPSATTMAMLNNPSASGVTPSLVGGSAPPNRRRGSSQSGPGDSQPADLDAFLGDVHTLTSSLRPTTVMADQAKRRPSQSSVVSFGTSHVGSSKLKTIVPMTATDGSSFGGGGEKNFITVAYTSTSATALASPQPPIQGNATKCRRRVWNTSLRPNKSSSAMAAMNGDVVPDPTATAVTEALWTMTSINATTKPVNGRVAQCSSVIAASQSVEAMTRVPPRALTGATRDSVVGGAKLATVKATTASAKTGGIVVDVARVCDSASSNTATPYPYIDEDLLAGGYITGPPQLVRSPVKGSLGVLLTARVASKSPSTNNTNSGRRSGSYTHGVVAPTACGCCSSQMGGHISASQQQPSLPRPKLHPLLHSHPRGAVDGKVITVSDGTSTTASEAPQQALATYGCGGSRETPTSTWNYPYGRAATSSPPEPTTAGSGKTQLDCRSRGDSTLGDAGEAFLSIEEEVSKDDLTDNGGMHLKVPLPPTFLSNDLSAQRGMAATNSTASADATGSHSGCVPKSGGSAAHTGCTRRSSLRPVVDLVTMEPIALMKGLPIPSGPSSVSRRGSASETEREVATSGEHGAAAATPRRRLMEFRNGDYTLPAFSPTSCISATVTEDSHSEAVKQRDRDWQVQQANEERRQRIQAFMSRRKAEKQLEEQRQGQMSKQEGQLQIYREMQGQQSILGATPHLEMSGTVGSGVNVINVPKHMRKSSPRLDRPVRQEIPAASFSPDAAMASTVSSPHIEVAAAASADILPAVRRGKGKCVAANTNVRAVVVFTSSAGAENNNEPMTLKDDNDGRRCRNGRISLSTAAPGLLNEGTVVVVKLSESCNTLKVQQPQECTRFFSVDEFLRINDAVVPKHVERPFNRRGSEVVTGVLSNGALPRRRLSSLTLTEMNRKFLAGVNVALLLASTEKAHYASLTAIREVVEGVLSHMPPQGELFASIAFVVGGNTQDMLSDSMRAVRSTFSTSPLFGATLDGVAYVAVTGLGHLSTMVTDAYKRCDLAEQQQQPNAGLLVMSLLLKQPRGSDVVLSSYLITDAGCDGSTYVAVLRKAQHTPFALFHSALGGPTLTTALVSVDVDDTATVMPLLNMQHRLTRVTNKPCHVGSVRRFLELAQQELQNRAEDGKPGRRRNSSTTTTKVAPERRRSSVSASSNNSASDSISRPPSSGHRGYKQQSGTRAQLHKRLLEEVATAQSILNDPANYRPKALREASDCRHTSALTSMAHASASSGVTLLVETTLHEQRRSVGDDAIPNLEVATLRKRLSTLKAADCSAPATADTVMLPFHGSGAARAHRHSPSPAAVAVSSPQLKQLLATRCPSGAPNVESDANATATPLRSPPTTCVNHQIVGFRPLQQSSSPLAGRNSVSMSMSAGYVRRGNDGGVAPHMTGFMNFEDLGDSTSASVGSRPGAGTLLKKGEREESQHLPLRPAAAMATKSLPEQRNAGDSESSRRGQLVSGDVASGSTQRPLFVPPGMANRGVYAGHKVLRAPPTRVGSNGPHSPSIVAMGPSDTPIVPSVAAIDSSLAHDVSVSVRQSSTAPGGEKESIPTSTKVRTLVIVDPRCRDTSNVTYDNTMVIATTEDDFEEYDVDEVREVASSQEEPIQAELLTELCETVLLGGNAAILGADSRPTAVCAKVLKSVVQTIFADMNHEGTHRSGHLSTSIVKVKGESVVDLLKDSGEAQKLVIAISPLFGSCIHGVIYSSITNSAAFNTTIDAALHRAASEDNGRDYSFLFCSLIFKLQLEEEGDVLVCSLVATFAGENVGLYTSVLDRSPLVPRALFHYALGGPSYTIALLGIGSKESRANQMLQVQQRLGEVSNRATHPGSVAKFVAGIRNDLTPNLIAKYESSRDQDERAATKEMIGRLAEMVKDADALLHDFDHHQPKAYLHEDQERDTAPPVKGFDSGSPAMAAPRSSNTNSTNVSNLTNCASAAIAVTATPPAATSRPAAPRALPCIMAANPEDEGVYIQSLVCCEQVLMGAGSVAVQGNSILCTSQGGMRYDSDEVIVRDEAHRSLSSKLMNQLVAKFLAGYHTGLLTADSSYSAFTPLMLRCIVNSILDTMLGREAEPREGLASSSSFKPLTVMGELRVSIALIKDEVTADLLPTDVDATYHRFEMEHMPLYGPRIVGVTSHLVSTPQDFDHFLSVAIDNADPALQSADPGIMVVSLTLTQRVSKPTNDVLVSSLLCTAVFDAVHHYERVLEGDTDEPLELFHNILRGPCFTVALLGISDEEENPGKLLRALHGITQARNRPPEVNSVLRHIQELQRGVVKLNERMATSSNEEEKEYILSHIKVAEHLLADAEALQRSTLSSIQPRTFVPLGGAPDLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZP9</accession>
    <name>A0A088RZP9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside triphosphate hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_331440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702236.1">
        <property type="nucleotide sequence ID" value="XM_010703934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZP9"/>
    <dbReference type="GeneID" id="22578297"/>
    <dbReference type="KEGG" id="lpan:LPMP_331440"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330020500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_331440"/>
    <dbReference type="eggNOG" id="ENOG502SIMD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273472at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="572" mass="61722" checksum="D591544F251B943C" modified="2014-11-26" version="1">MQSTTASWETMSDSTARARVLRLRQSAAPLQDVYGAFSPWQHLSTSLPGLDSLLSVAGVCEGVSGSDDRSGVESTIGGLPVGGLHELYGPPLSGKSWLLRRVGAAYVRRMTAYRQWYHDELERVSKRAVEATLFTRKTDNEAHAAKDDEDVDSEAEDAHICANSASPSPITAMEEWDLYVCLVRGAGADSKTHSLTASPPSPSLLSPDVRSWLKELVAPFDSSSTLDRQVESIVTGPVHGYSSSHQQQHRDYAEQHIHFRVVHSPNELLAFLECLGGGAASVPSTSRVFTNTTYSAAPPVPRVALQQQLLPSQLARSSLTTAMRGQKQHRSPGTTMPSSPSFPLTCGSLPQCTWRLQRQRLLLLDGLDALWLHPSLGNHSATHTGQWFAEELHRQLRTVLLPRLGYAASDSTLLTAPSSTAAAAPMSPHPQHVLYSTVVFTNGCHGSSRGFLTAQQLEARLAGPAGGVEGWAATLPRPSGNAAWCRAVDTRCLIEPAHLGLVSILTPSFSYVRPAMAPHESSAVYQNGRRITGTFRQSTANYLESLVTVVKGGSRVAATWVLRNAADGEQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZS2</accession>
    <name>A0A088RZS2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_311960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701585.1">
        <property type="nucleotide sequence ID" value="XM_010703283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZS2"/>
    <dbReference type="GeneID" id="22577622"/>
    <dbReference type="KEGG" id="lpan:LPMP_311960"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310026500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_311960"/>
    <dbReference type="OrthoDB" id="265212at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="351" mass="37987" checksum="B1FF4A3B05E7B701" modified="2014-11-26" version="1">MSLRASGSPQLPRPLEGRESPPPIISDSDSTPRLPSLYQRVLDGRSSPLSIRSATPNVSGISRSEDEMHSALRDPLRSSLSPHIVAFNSFSVLDSNSSPPPLILSEKTFSSISVNTSLYNGGRKGDALGAQQADSAISGCTGSQNLGAYVDHENWMSSSIELEAVDVRKVITVMKGKKQERCHAALSPVPEVVVSAEKSRLKQTEMPNPRRGMLPSGRKRSVSINAPPDTPRERQALITLRPRQAAVVVQQQQYMIRRPYMPTGGGLPTLRQLPGFTSAPYSMALRQVPPAVAVSRAHPLELSISTSSEVDNHPASSKSRERSAEIGTASWRRMFWVCGGSAKQVAPKNHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S087</accession>
    <name>A0A088S087_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_333280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702416.1">
        <property type="nucleotide sequence ID" value="XM_010704114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S087"/>
    <dbReference type="GeneID" id="22578481"/>
    <dbReference type="KEGG" id="lpan:LPMP_333280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330041100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_333280"/>
    <dbReference type="eggNOG" id="ENOG502SKB1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="249432at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="532" mass="56969" checksum="B049FA161D024005" modified="2014-11-26" version="1">MLSRSGVSDSEVLIRLDTSVLEGRLNNLANEWETDLKCIRARVETCAASVRSVTGDVDAIQRFLLSYHRQEMAATLAVHPTEASGVTAEDDVQRLLNRFVTATTTTEGSSTENLLGMVAVARRLLAENEALRTLLESATGALSTRPTGSTGLQQEVAQLRDQTTQQSAALRNITSWLPMLGLTQNDCASEASDGDVSLVMGAPTESTVDGHTIEAIISRSPLLLSLRQILLRDLTERLTSVVDQQSRDFHDTVAHLEDRLQRGRKGTADLVGAQSTGVVAELQETVRSLKKRLKDMDECAVKRDEFTSLMRCKADALLMPAKADNASLTDLESRLVARCAELEERCAFADAERAEFRALLRSIIVALPHSTIAAAPSSLKEASQATVQTRSTVVAPEALLGEILPALRANPAFPALAPPSRQEGAPPHPRGASTPQQIVRVVGTSHGSGVHGVILGSATQKEHVKPLGNPTAAQRETLQANPALSPSADGSVVAIGMTPTQGAYAAYVSEQLTRRHVALLPALPYERASSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0W4</accession>
    <name>A0A088S0W4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chaperone protein DNAj, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_342830</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702709.1">
        <property type="nucleotide sequence ID" value="XM_010704407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0W4"/>
    <dbReference type="GeneID" id="22578788"/>
    <dbReference type="KEGG" id="lpan:LPMP_342830"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340034500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_342830"/>
    <dbReference type="eggNOG" id="KOG0712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000013">
        <property type="entry name" value="DnaJ subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="49"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="8">
        <location>
            <begin position="186"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="5">
        <location>
            <begin position="186"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="429"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="429"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIO01909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="479" mass="51181" checksum="8F4C0154D8AAFB26" modified="2014-11-26" version="1">MLRHLSALATRRRACAFSASASVLTGSTASSTFCSTTTPVRLYSSGNKDYYKTLGVDRNSDLKEIKKAYRKRALETHPDQGGNKEEFAEVAEAYEVLSNPEKRKVYDQYGSEAATNPNMGGPGMSGFGAGGRSAEDIFAEFFRGGMGGMGGFGDMFGGGPGGRQGTPTLQPLEVRTRLTLEDVYKGVTKTMRVNRPQVCSECNGFGSKSKTEKPKCAQCSGSGHVVQQHRMGPGMVQQTISECPRCRGTGSMAKPEDQCPKCHGKGYRTVSQDVTIEIPAGVPSNVTLVVRGEGGTIPGAPPADMHLHVELSPHRVFQRRGNDLIVNKDVTLQEALLGLHMPLKLLDGRTVNVETTADQVLKPEGVIKITGEGLPGTSGERGDIYIFTHLKMPNKLNDEQKENIKSAFGAPGRDASASPGNTVRARVMRESREQLEEQKRSLWASQESGSYSGGSGGSSRRSAGSAPGGGAQQVECATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1A1</accession>
    <name>A0A088S1A1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease, putative</fullName>
            <ecNumber evidence="7">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">AAT27.2</name>
        <name evidence="7" type="ORF">LPMP_345190</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="7"/>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702938.1">
        <property type="nucleotide sequence ID" value="XM_010704636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1A1"/>
    <dbReference type="GeneID" id="22579024"/>
    <dbReference type="KEGG" id="lpan:LPMP_345190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340060100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_345190"/>
    <dbReference type="eggNOG" id="KOG1305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28208at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF649">
        <property type="entry name" value="ACID TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="7"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO02138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="405" mass="44955" checksum="48B18A58C18D7990" modified="2014-11-26" version="1">MSYVSLLGVALSISVATIGAGVLAIPATFESDGIALVALTLLAVGVFTVFSIDFLILCIDKLGANSYEEISDVLLGRVFKEVIRWMLIVYNIGTAVGYIVVIGEIFTPMLPVIRLYVPWLSSSSHIMIASWTLVMLPFSCFPKVSHLYVTSLLAIAATFFISGIIVYRYFVPLSFTQATRNSEEGIKYFRFSCRSLLTLPVVMFAFDCQSLVFQVYAGLNHPSRYSMAKVATASVLVTSLVYGVVGFFGYVTNTPHVRGNILTNYNPIRDHLFAIGETFYSITVNVAYVLILMPCRDAIFQMWYGFSHTHEFLEIPQYSNLLVSVLLSFLCLCFALLAPGFLYIVALMGAFCSSTLCFTYPALFRQRLHVLGLAPYTGYEHFAVWAMYFFGFVGFMMGLFALAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1B6</accession>
    <name>A0A088S1B6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sm protein F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_344320</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702854.1">
        <property type="nucleotide sequence ID" value="XM_010704552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1B6"/>
    <dbReference type="GeneID" id="22578937"/>
    <dbReference type="KEGG" id="lpan:LPMP_344320"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340050700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_344320"/>
    <dbReference type="eggNOG" id="KOG3482">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="409625at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01722">
        <property type="entry name" value="Sm_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000080">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm-F, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034100">
        <property type="entry name" value="Sm_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006609">
        <property type="entry name" value="snRNP_SmF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="5"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIO02054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="77" mass="8610" checksum="390A41B535087D9C" modified="2014-11-26" version="1">MEANVPGAFLHSLVGKKVLVKSKWGPVYEGNLVSCDTFMNLQLRDAVEHAKQDTELGEMLLRNNNILYIREATTTSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1C1</accession>
    <name>A0A088S1C1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_030360</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009372">
        <property type="protein sequence ID" value="AIN95271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700979.1">
        <property type="nucleotide sequence ID" value="XM_010702677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1C1"/>
    <dbReference type="GeneID" id="22571902"/>
    <dbReference type="KEGG" id="lpan:LPMP_030360"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_030008600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_030360"/>
    <dbReference type="eggNOG" id="KOG2563">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="422206at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17334">
        <property type="entry name" value="MFS_SLC49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049680">
        <property type="entry name" value="FLVCR1-2_SLC49-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 49 MEMBER A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="485"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="517"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="558"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="589"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="92"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="306"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="655"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="661"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="675"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN95271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="687" mass="75759" checksum="877DB0F599704314" modified="2014-11-26" version="1">MSSNGKNSHRRYAESGVQQPSTSAKPTKTPSNTVLAFAQWEEENHVDDAALVAAMDDENADPLLHPAHTRALSHIEQREENRLRGDPWRFAVTPIFCLLSISNAMQWIAFAPIVDEVRTYFNMNATQVNFLATTYVIAYVVIVFLSCKLYEVTGIKMGVLIAAAANALGALLKIIALYVWPNAVLLYLAQVFNSFTEVLTIATPPLISNRWFPENERMVANTVMSSSLNFGCGIGVLIPTFFVGPTKQSKNHFGNFFWFHFTYAALVLVLVIFLFPKKPRYAASHVAARQQNCEERRLRALNHVLHDPHSDEDEELDHQTRPHPKGKRTSSENEPLAVGVADVCEEDNCDPAGVKKSSVAAATTGNQCSSSRGTAVAHVTDEMQDAESENEEEVPEVQPVNVFSVLMDCFRECRSNWSFILLAISSAAELGLIWGVATVLPQMLAPYGISEAISGWIGFLNLVLGTVVCPFFMPLVDRYGRRYKLLLCALSVVVVVVMVLLTLLLHFGPAVHEDGKYYVVVVFVLWGGIAGMCQNFMMPLMFEYVVELTFPMAESTSAPVLTWSACLTNFLLTLIFGEVLTDTPTENKALRTFIGASVVSVIGCVTLLLTKPLTKRTDYEKHQVEALEQRKRRLQSAAAAVAGIDEAGLTCNPGGAAVDMSASQSQLQTRNSAHSHQDRDATKRKMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1C8</accession>
    <name>A0A088S1C8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_330720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01365.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702165.1">
        <property type="nucleotide sequence ID" value="XM_010703863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1C8"/>
    <dbReference type="GeneID" id="22578225"/>
    <dbReference type="KEGG" id="lpan:LPMP_330720"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330011800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_330720"/>
    <dbReference type="eggNOG" id="KOG1354">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6274823at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000009">
        <property type="entry name" value="PP2A_PR55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11871">
        <property type="entry name" value="PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00600">
        <property type="entry name" value="PP2APR55"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU331113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO01365.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="848" mass="91093" checksum="A44C2B5CD00487C8" modified="2026-01-28" version="2">MAARLPSPFFWSLPRYNTPKAQSHASVRRHRRFLVLVDNLFALASYFAAASAATNSLPFMLPKLHLDGTLNKRTFNVQERMSEERQPGMYSPRVASSQPTKGLSVPSQIDSATSAHSSSSSFSAPAHTGSLSSPHPPPHEISLLEDGAVGISDPEMAAILAAKSRHSSGERSPPLDRLGSIGGGMGPGGYSHSSKRRAAPFATLVDHQQARQVVPQHAKDGDVTAGKASDLERDEDGRVSEGASPVPRVASTHPRMVKCRATSPSTSSRASGRSTSAVVETSLGATSSSAPTPSAISIMTAEELYILGKPFQAYMSTLSTRPSSGDTPATPTSTSGSGAPAAKATVASGTHITTVFHHNPSQYISALANQGDFVAVGDRTGRVVVMRQRAMAAGPRRTLLDIIQRSGEAEESEAAKRHSSSASSASSPPSTPRHATTLNHVRDPYDFYVAQQAYVPVIDTLSSVEVSPTVMALAFLPQSGPTTYLLTANEKVPKLYKIMSVRESANPFRAVDKIGTKSIGPLTASSRMSTVTMKPVSRYAMNHEYNINSICPIAYSDQFATADDATVLLWCTEYPDTSIETHDLRSPYEDGPRETIRTLRNFPHEPFLFFVATSGGSVRVVDTRQTLRWAGQAAQAFVNPPREEDGPFSNVTNSVCDCALSPSGRYIAGRDFMSVCLWDIRMAGNGGARNSPASPRRQPPAARGGDGSSECSMVRRWALHPHLCDDLDTIYQSNLLFDKFDVQFLSSRQVCTGGFNNTLYAMDVESISADTASDIRTFQLLKTDGISEFRRTTVSAHRLGEDRISTGQGLGSRMTLMSRPCMSMSGTCGMMVACGQALLQFSYNGLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1E8</accession>
    <name>A0A088S1E8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glyceraldehyde-3-phosphate dehydrogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_344600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702879.1">
        <property type="nucleotide sequence ID" value="XM_010704577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1E8"/>
    <dbReference type="GeneID" id="22578965"/>
    <dbReference type="KEGG" id="lpan:LPMP_344600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340053900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_344600"/>
    <dbReference type="eggNOG" id="KOG0657">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1152826at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF136">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="4">
        <location>
            <begin position="3"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO02079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="349" mass="36748" checksum="6C9A2BA05D71D17B" modified="2014-11-26" version="1">MSITIGINGFGPVGKSALFAALADPSFTVTAVVDASVCAAYIAYVIEQEYPRRNPAGTPIRVTDTRKDQIVLNDTQVIYVSAAQDPQLSLWKQYGARYVLECTGLYTTRSRSWGHVTGGAAGIFIAAASADINTVMASSALERLSASLPVCAAGTPIGAAVAPVLDALAKVMEVERVNYTALYGTQPQHPIGAKSEDSRDWRQARLQSYANCAMASSRDNGAETVCALLPHLAGHVSAGAFQVPVLQGCAIDLVVYTKEATSADVVASAFAHSMIDSESTARVCIANRPMISVDCIGNSRVILDAASSSSSTDGKVHRMVLWVDVECYYAAVLLSLVKQAHAIHAPPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1J7</accession>
    <name>A0A088S1J7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_351110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703048.1">
        <property type="nucleotide sequence ID" value="XM_010704746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1J7"/>
    <dbReference type="GeneID" id="22579140"/>
    <dbReference type="KEGG" id="lpan:LPMP_351110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350016700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_351110"/>
    <dbReference type="eggNOG" id="ENOG502SEEW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273053at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="577" mass="63361" checksum="7D5A0C008798A784" modified="2014-11-26" version="1">MPLTSTMATEHGGRRIYHVGNAVLSVVVFLITVVLSMIVLDPQFSSYLLSARYRTPPIGFTERELLEGFTPVVVDAEKHTVLVVPVAGVQSARYVSRALGAFFSVDLPFASGSGAMVNNGKETEMPSRLVIALADVFSAVLLRDGVDNATQSHDTTSQRGGTVPFSTRRRSVLHLCSALSCVTPYVAQQWSDRIATASLRTHRTAYRATTFGSRTRPITNFALVFGEASESLAAMRELAEHRVLTPQFPPTRLKHRPAMPLVGRLDYADLQALCSSCKQCSYRSSVKHAQLATVLKTQAEQLPTEDSRRRLFKEWVRHNDSYSGTSTWGTVEVVPFAFVVFEDSYTLHDFSPDLVHVDVGSGDSVAALAYLKALVSATGVPEPLQPRNLLVSLFASEWVNDIVDTLLQLQVGQHYHAIPLHNSCIGLEMFDPREEWSVAHLRSWWNKSSLVGTYVSPFLEQSRATQTPLCTVLLSLQVHTLDKLLQMTSKVVRSYPPAASPVERFFYYSAGLSPADEEPLTAPPHDATDAKTSTVASASSGVGEVIGFVAQNIYFLIPVGIGFALTQNLCRRRRVCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S244</accession>
    <name>A0A088S244_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_351330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703071.1">
        <property type="nucleotide sequence ID" value="XM_010704769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S244"/>
    <dbReference type="GeneID" id="22579162"/>
    <dbReference type="KEGG" id="lpan:LPMP_351330"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350018900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_351330"/>
    <dbReference type="eggNOG" id="ENOG502SCDA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="247073at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="423" mass="45567" checksum="78DA018FEFF47D76" modified="2014-11-26" version="1">MQPGVSEMARGSYRTLHTSASAARRPKTDYGILLEAKRRSEGTINRKSASTRSCAAAEQAGQRLSSPRRRGVREAGNVIHPTTTWTQRTTSLLPTPRGQCTPMLQNGRTSPRGEQHVGRAVSDEKMDDAASALLSELQQVVVRVSHQMVDERRRAAQQRKQIDTLETIVAEQDAMLDALRTQHNAAQYEKCYQNELRCRGVDSVQPKGYNRESCRTSEWRISAAQVDDCVCAEFRRLSLIYESSPFSGFDEVSPIIAAVLRSLATQVLQLRCAARENEVKASSLSRGESSFAFQLPAGSAPLVTAPAVSSPSVMLSFNRHAPAANCSNASAVDRVTPTMAPEAQTKASVSATPAAGPHHASLGSASLTNGEEGKLFCVDMDTGMNTTVRAAARPASEASVSVSNSVCEDAASILSDIRARYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S272</accession>
    <name>A0A088S272_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cysteine synthase</fullName>
            <ecNumber evidence="4">2.5.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_353670</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="4"/>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703303.1">
        <property type="nucleotide sequence ID" value="XM_010705001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S272"/>
    <dbReference type="GeneID" id="22579395"/>
    <dbReference type="KEGG" id="lpan:LPMP_353670"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350044800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_353670"/>
    <dbReference type="eggNOG" id="KOG1252">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000067">
        <property type="entry name" value="Cysteine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005856">
        <property type="entry name" value="Cys_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005859">
        <property type="entry name" value="CysK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01139">
        <property type="entry name" value="cysK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01136">
        <property type="entry name" value="cysKM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="12">
        <location>
            <begin position="15"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="186"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="11">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIO02503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="333" mass="35401" checksum="3BED38AB40350503" modified="2014-11-26" version="1">MAAPFDMSKNVAESIDQLIGHTPALYLNKLNHTKAKIVLKMECENPMSSVKDRLALAIYDKAEKEGKLIRGKSIVVESTSGNTGVALAHLGAIRGYKIIITMPESMSLERRCLLRIFGAEVILTPAALGMKGAMAMAKKIVAANPNAVLAEQFATKYNALIHEETTGPEIWDQTHHCVDCFIAGVGTGGTLTGVARALKKVGSHARIIAVEPVESPVLSGGKPGPHKIQGIGAGFVPAVLDRSLIDEVFCVSGDDAIETALKLTRSDGVCCGFSGGANVYAALKIAERPEMEGKTIVTVIPSFGERYLSTVLYKSVRDEVSSLPVVDASELQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S287</accession>
    <name>A0A088S287_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_060250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703908.1">
        <property type="nucleotide sequence ID" value="XM_010705606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S287"/>
    <dbReference type="GeneID" id="22572231"/>
    <dbReference type="KEGG" id="lpan:LPMP_060250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060008000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_060250"/>
    <dbReference type="eggNOG" id="ENOG502QVIP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="274950at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN95586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="312" mass="34733" checksum="188233EC69DAF968" modified="2014-11-26" version="1">MDSTYKEPSGAAVPTSYAVLSLPSKATMRRKGYNPDDVNYNGGLALHPLATWRTFSLPDGCTYKDAVTAVQTANAKPWGPIKIRLNFSDGRYEQFERAAPSVMDSLQSTTTYNPNSVFKEETLSLSTMRRAQQQPRLRPLVDERGHHLSSKPIPRTFAPEELYKNCPPPVLCQPGYDFTPVSYNTFLLKPQDPPQGVRNVQSNFTHSICDYRPRSYLRPEGATGTTHASRHCHCNEVFQVGDYTMDFACEGTTVNHRNRLVMKDYSRIGTLKANSSVVGRRHARRPRFGCTAMAARESSATAVSSAADEETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S297</accession>
    <name>A0A088S297_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_060360</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703918.1">
        <property type="nucleotide sequence ID" value="XM_010705616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S297"/>
    <dbReference type="GeneID" id="22572242"/>
    <dbReference type="KEGG" id="lpan:LPMP_060360"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060009200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_060360"/>
    <dbReference type="eggNOG" id="ENOG502QV34">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041367">
        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="5">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN95596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="375" mass="41989" checksum="33257CAFC34B45E3" modified="2014-11-26" version="1">MIPQRQKPGSQGKRYWQKKKSLYDEYLADSGDSEEVGADEEQGETFECEQYCVNMDVNILIQQTVQNIVQSVCLEDPDGFATFGDHELICFAAAVKHNSSIMSLQIRYLDVSDVSIIPLCRALHGHPSIRALDLSGTRGGEGTSKALRQLVCTNSKIIFMRLEDTMVNPKDAHVIEKATRYNSMACTDPNNNPFHLGLLRRISAMDEEEHKFHEQLHARPWLLGNGSFSPKRSKKTVLSTAASSHIGGEICAQFIQGRCPYGSRCKYIHPERTVALKNVVASSLYNRSEQYGEGDLVSTVLSTTAGSRQRLQSRLRPPAFMLKKVEQCERQEETHEMSMESPPVVDASFAQPLAHSWWMMSVTVVCCCVIIVTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2A2</accession>
    <name>A0A088S2A2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_352090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703146.1">
        <property type="nucleotide sequence ID" value="XM_010704844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2A2"/>
    <dbReference type="GeneID" id="22579238"/>
    <dbReference type="KEGG" id="lpan:LPMP_352090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350027000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_352090"/>
    <dbReference type="eggNOG" id="ENOG502SAZP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="263686at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="154"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO02346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="285" mass="32174" checksum="301C4A7A406BA6BD" modified="2014-11-26" version="1">MGEEVAVDVPPVRLRNSTSSTPNGSHDAAQLQQLRRQLEKATANLKAMANANRRQKKEYQQQQAEWLVLFHECEARLHNVQSSQASRERLLCHELSGAIKQLLSEVQAQSVKERAVEQAHGCDKAEWDTQRVALLRELEAARAALATQLSANSADDHNEEADLLHTELETLRQSFASQQRSLEEKLKQTQSTLQSTQSELNRHLQERDQHNYLVAQCRLFIKQVCQPGFSVVKGPSLEPVEKDRPEPTGFVLVPLVVLLHGYALLPEGDRQAMIDYYDGRAKSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2J3</accession>
    <name>A0A088S2J3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_341480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702575.1">
        <property type="nucleotide sequence ID" value="XM_010704273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2J3"/>
    <dbReference type="GeneID" id="22578653"/>
    <dbReference type="KEGG" id="lpan:LPMP_341480"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340020800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_341480"/>
    <dbReference type="eggNOG" id="ENOG502S6Z9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267118at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="434" mass="45792" checksum="4E75268A2F6A1CE3" modified="2014-11-26" version="1">MAPVNVQRVYSVFHLFAVDTADAHAGAAAAQDAIRESYIPVCFLAAAAREIGYYPTSSAVSQFTKTVPSAAAGAVTFAAFLQFCENVAHTNQPGRSAIYKLVDDIDPRGSGMISHRELLLVLTSGSATITDGEVDAAMKLLDPTNCGYVQLADLAALLIDSCERQQQPEKQQQRCSAARDSHSRQTSAQPEDSRQHLKQWRGDFTKRGYETPPSPPLTTAAAEGERAQAPEQRRSAAAVGECDSSLKRTGVGLTGEAAFQPHGSLCDRQNTAEQTQTPMTVDADVQLSKRHSTPTLWRRRFAKSSSVAVSPATPLQRAGGGSAASSPAAQTPVRPLQPTVSAAATEGAPPQDKAVNNEPHLHYRGGADANGGARYNGLKERNSKQQVYSSAELNARGGGVFAGGNRSSGAEAALVTTAAMPTKKADGLKCCVML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2K6</accession>
    <name>A0A088S2K6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SNF7-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_353520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703289.1">
        <property type="nucleotide sequence ID" value="XM_010704987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2K6"/>
    <dbReference type="GeneID" id="22579381"/>
    <dbReference type="KEGG" id="lpan:LPMP_353520"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350043100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_353520"/>
    <dbReference type="eggNOG" id="KOG3229">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2329734at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="217" mass="24672" checksum="0FCA779EC7A6DDB1" modified="2014-11-26" version="1">MQALGSIFHKTTPEEEVRKWTRNLRSEQRKIELQINKIQREETKVKMSMKQAAKQNDEVAVRMLAKEMIRSRKAVNRLYASKAQMNSVSMQLQNQSSQMKMSGSLKKSGEIMKEMNNLVKVKGIQQSMMAMGKEMAKAGLIEEIMNDTIDEALDDNISDTELEDEVNKVVMDVVQGQMDGARVGASRIPTAQQQQQEVAEEEGEDELMEKFNALRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2M7</accession>
    <name>A0A088S2M7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_341940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702620.1">
        <property type="nucleotide sequence ID" value="XM_010704318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2M7"/>
    <dbReference type="GeneID" id="22578699"/>
    <dbReference type="KEGG" id="lpan:LPMP_341940"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340025600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_341940"/>
    <dbReference type="eggNOG" id="ENOG502RZNH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272613at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="642"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="688" mass="76694" checksum="AD0C9B201BA52A54" modified="2014-11-26" version="1">MASTGTYIAEWFRHHLSSVVTFQKQFVDDVSEKVKEQKAQFDRHARETKERAVQLHLDELEEKYLCCVCGRGGEIREDDELVYSTYSMIELPPREMLEAAVREELADAEMSDERIKQQQRMLTFRQRRSQKSSTKPAATYDSDTSSDSSSDASVAPSGGRPERTKKGKHQRRKHRSSQHKRAKSSSQRHVVSWPRRQREESEDQHFDYDVREKHTTLDTSKPNTQKSLSSENPPARSVTACSGAMAIQTSDIAVMDPDMVGPLDVRNTVYKIQHAVLHKEARVRRKSVVVHKDKGLMTIEESEIEMFSHFFQRPVHGYLCTACYTCARRRLDTLTQQIRAILFKAEHPILRRLPAKELEALMTGNQVPATFIQSILAVQRRWARLMDEQRMELHRAEAGAGPAQGPTCAFAAEERARGTSQENDATTLMTALPDESILILREEVRCGACQRRLACFFEPKSVLFLCQFCTARDRFYREHAVCINDEAMPLTLTHLLQSLALYYRGTHQQMELRQAPLSAIPEAQTDLFPLTKIMRETEGLFACQAPAVANADLQGCQRVAEVEPTLSAETSTHGTEVPVARPCTSAASTRWVSGSAVPLQELRERVGRTMISLFDGVQVEGSGVNLFKNTASASSASSVSDLFQSAPVPQPPLLPKDGSSVGQGGARAAEHLLGNGSTAASAPPAAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3E2</accession>
    <name>A0A088S3E2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_356200</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703549.1">
        <property type="nucleotide sequence ID" value="XM_010705247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3E2"/>
    <dbReference type="GeneID" id="22579648"/>
    <dbReference type="KEGG" id="lpan:LPMP_356200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350070400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_356200"/>
    <dbReference type="eggNOG" id="KOG2307">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="332281at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009316">
        <property type="entry name" value="COG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024603">
        <property type="entry name" value="COG_complex_COG2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024602">
        <property type="entry name" value="COG_su2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12022">
        <property type="entry name" value="COG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06148">
        <property type="entry name" value="COG2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 2 N-terminal" evidence="10">
        <location>
            <begin position="80"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="COG complex component COG2 C-terminal" evidence="11">
        <location>
            <begin position="576"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="390"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="664"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="878"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="671"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="894"/>
            <end position="906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIO02749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="980" mass="105816" checksum="525D49EE427F01A2" modified="2014-11-26" version="1">MSHNFTVVTPLEESEQPSRDFAVSPEGSSRAALSNGVGDPSPSPLLGPNDATPNGPSSDNAANAGADAELLKQHLQLIQLCFAEHEFGIIVDEDDYAGGSTSSSSSSDASSLSSSFDSVNGYNSALQRRRPHGLPAYDPLTFVKGKVQHGVPLTSLSQDLLTYAAYLEEKIAQCVKTDVHTAFVNVSGHLVGMRDELSYMASPLTAAMEKLSTVVGQLSMMSQKVKGKVEASCVAEMERAFDAMYLRCMAVYETIAYQLDDLAGLLHITADSAAWTARSAATGTGTSGRSASIFPLAMASREGSDTSGTAAGKVTFSIASDARLPDAALDVLEDAVLLFQELKEFHQRLTSLPSRQQERVEVVSYVAAAEQSVMGVLEVVLSHTSPFAVSPTSKNDAASSMSSPSATGGNESATSASLTVGSPVARQLFGRVIELYAQMGEVKQFSAVFRNVVLRPQLETVVSWKAATQARQSAEGTVALLKRVKAVLQTTFLPLLPLLREHYGPTLHPTATIVWPLLSETLVKKLPSLYEVGIPNHFQAKYMAAYELLAIVESSCADLEELAVLRESSDVILWNHKWNLNVYAALRVSEVDKALQSVSSSLDRLPAAANSHYHFRLFYIAQQQLLHLFSSSVFLLLCTPLFLRQTVVCCYRVLMRVQEAVLKSTPTHSDPTAEEKRLTDAPESESSSPPAEGTHETLLLVIADAHTLRTFLTGQLLDVILGRLAAGSGCALTEMTSMTATTSSAPSSERTTKDLVTDVLQFASASVCSQFVQRMSEALVRQITDAVVVPLQNLKSVRSMYSHTRKTMPSAPSWYVAPALHPLQKFAEEALRRGFNETALQDSVAEMLRAVIAHFVALARETLLTAKKTEESWEKLRRRKEGSLMSQVAEATPGSSEEASAGAVSAVGGQRVTMETATDRDKMTIQLWMDARAMLEGVQTPPLSLPSVTAAEFFEPAFDLLRRAEWIQGGDIPEPPDVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3P7</accession>
    <name>A0A088S3P7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative xylulokinase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Xylulokinase, putative</fullName>
            <ecNumber evidence="5">2.7.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_350250</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="PLoS Negl. Trop. Dis." volume="10" first="E0004326" last="E0004326">
            <title>The Dynamics of Lateral Gene Transfer in Genus Leishmania - A Route for Adaptation and Species Diversification.</title>
            <authorList>
                <person name="Vikeved E."/>
                <person name="Backlund A."/>
                <person name="Alsmark C."/>
            </authorList>
            <dbReference type="PubMed" id="26730948"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">L967/96</strain>
            <strain evidence="6">MHOM/PA/71/LS94</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.17" evidence="5"/>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KM411857">
        <property type="protein sequence ID" value="AKK31302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KM411858">
        <property type="protein sequence ID" value="AKK31303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702965.1">
        <property type="nucleotide sequence ID" value="XM_010704663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3P7"/>
    <dbReference type="GeneID" id="22579054"/>
    <dbReference type="KEGG" id="lpan:LPMP_350250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_350250"/>
    <dbReference type="eggNOG" id="KOG2517">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1728974at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004856">
        <property type="term" value="F:D-xylulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050406">
        <property type="entry name" value="FGGY_Carb_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43095">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43095:SF6">
        <property type="entry name" value="XYLULOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="4">
        <location>
            <begin position="36"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO02165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKK31302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKK31303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="161" mass="17918" checksum="06F2098BDEC17D8C" modified="2014-11-26" version="1">MGRPSTVPPPPSQRLARTRCRMSRTPNRGGGGINSTMNELKKRQDMRSVRAIGLSGHTHGTTLLHRSYNVLRLCILRCGGRCYRECEGLGRAVLKSRGITGNLMMPGFTAGKRLWVKKHKPEIVVKGGQGATPEGLRPLLHNGRLCLRGVRFLWHHVDGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S4N3</accession>
    <name>A0A088S4N3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">N-acetyltransferase subunit ARD1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_130260</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. ARD1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697109.1">
        <property type="nucleotide sequence ID" value="XM_010698807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S4N3"/>
    <dbReference type="GeneID" id="22573136"/>
    <dbReference type="KEGG" id="lpan:LPMP_130260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290030200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_130260"/>
    <dbReference type="eggNOG" id="KOG3235">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25586at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990190">
        <property type="term" value="F:protein-N-terminal-glutamate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000138">
        <property type="entry name" value="N-acetyltransferase subunit ARD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045047">
        <property type="entry name" value="Ard1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091:SF4">
        <property type="entry name" value="N-TERMINAL AMINO-ACID N(ALPHA)-ACETYLTRANSFERASE NATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="179"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN96456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="264" mass="29348" checksum="78E896A1C52BA3A8" modified="2014-11-26" version="1">MQLRRATMEDMYEMQHSNLRCLPENYNLRYYYYHLLSWPQLLYVQQDYNRNTVGYVLGKMDDEEVAEKKHGHITSLAVLRSHRKLGIASRVMRATMKEMDAEYDAHYCSLHVRKTNDAALHLYQDTLGFRCVGVEEKYYMDEEDAYHMKSFFHQENPGSYVDDHKRLIRKTVPVEVEGYPAATGTSLPAVGGRGGDRNGKKGNDKAAKEISAKEREAAMAELLGLDADGKGKGAGGGGGKGKSGNNKNSASGGGGGKRGSGKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S547</accession>
    <name>A0A088S547_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Poly(A)-specific ribonuclease PARN, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_356520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703580.1">
        <property type="nucleotide sequence ID" value="XM_010705278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S547"/>
    <dbReference type="GeneID" id="22579680"/>
    <dbReference type="KEGG" id="lpan:LPMP_356520"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350074100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_356520"/>
    <dbReference type="eggNOG" id="KOG1990">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="414075at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051181">
        <property type="entry name" value="CAF1_poly(A)_ribonucleases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15092">
        <property type="entry name" value="POLY A -SPECIFIC RIBONUCLEASE/TARGET OF EGR1, MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15092:SF22">
        <property type="entry name" value="POLY(A)-SPECIFIC RIBONUCLEASE PNLDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="510" mass="58833" checksum="ADC926FE442F1691" modified="2014-11-26" version="1">MDITRFNQLVALPDFAREVEKCEFFAIDQEMTGVDVPGIPTQFGAPPEAVYHAKRIAVETYNAFQIGIALFRKTENNVYEVRPYNFYLLNDSGDLRLALPAVSFLAANRMNFQMWLTAGLPFCNAQEELDYEKQITTLFTDEVEQEISNDLVKAIDEWIPTASAPLVKELSCSLNLAQRLQAFLSHRYDSRIVINYDGKPYLAQKIKFTLTKLSKAEWISEKEKRRLRCERDRARQLGFRQFWKILLKSRKPIVGHNFMQDIMFMIHMHETPLPVDYLEFKKLLQHTLPTIYDTKTMATKLMGDNAFQVTHLESLYQECRRRAGLSTDEFTLQYRLPPGFYNYNDYAGKQQSKAHEAAYDAYMTGITFLLLHKLYPDAFSEVKNVISAFGSAYLFCIDEDDQVANNNTFILKCTVPCYTEEIEALFFASEDMTAQAAANEKVDIRKLSYQVSSVAASDRSKRCTTFCVRMKQRVGVNDLNSRLQSLRDKELSDSTNFNRLLLDCITLQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S558</accession>
    <name>A0A088S558_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_356670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703595.1">
        <property type="nucleotide sequence ID" value="XM_010705293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S558"/>
    <dbReference type="GeneID" id="22579695"/>
    <dbReference type="KEGG" id="lpan:LPMP_356670"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350076300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_356670"/>
    <dbReference type="eggNOG" id="ENOG502S4IQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="263588at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO02795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="651" mass="71469" checksum="8A57119414692B36" modified="2014-11-26" version="1">MENRGKSEWRLLVVLAVGAIAYYLFTLKLAPNPEERRLAALRRIRDGASPLTLLEEGFSSVELLHAGVPREALNSASAVSLPTSPSQTPRRESCSRSPSTPSSCSRVCDPLMMVVTDTMHVVKKALRGGRRCRSMSTSISNVREATRSKTTGSTTALSSRSSQLHGKSPSNSSLRSSTRLTAHVQSPPVQHEFYDCLSPMRSSATRTPAGALRVRVAALSAVITHDYVSESATYNYPLEVLRFLHEDRSRLSIMAENCSALEGDEVLTTEVYVKRSLERARAAAEDAKAYFKVSLSTAARNIATTVMESYVNIYTGPSPVILAALYLVKGNIAYTIQLQTHIGTYEERLPDLLYTAQSARLLCAEKTPCGWWRRRPGRNEYHVQAQNVDRTYVVEIPVDVAVRAPRTPHALRSELILMPCSSGGDTGAQWSAIVAVVPSAAREHARKGEKQHKVIPLLHDAHVSIELTVHMPDSAAAGTTSSPPPLPPPLAAVMAREATARDAQLFSSVYRSAELTMPLPPPEYFQTVVCEHPYETSVTLFITSLTSAESFEVELRCLKDMNDVSLKQLLSYVPTLLLNHARPRCSTNAAGQACFSVEGLAVSPTETTLRVYGVQQGAETWLIMRWLCASTAVELSELEQYRSELLKRVLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S6E4</accession>
    <name>A0A088S6E4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_170830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697774.1">
        <property type="nucleotide sequence ID" value="XM_010699472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S6E4"/>
    <dbReference type="GeneID" id="22573826"/>
    <dbReference type="KEGG" id="lpan:LPMP_170830"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170014100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_170830"/>
    <dbReference type="eggNOG" id="ENOG502QQ70">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271771at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="523" mass="58105" checksum="C57E1692C4AF972F" modified="2014-11-26" version="1">MRRRAVTEVKEAPPASPRRSGKTNFFEVTKPPSNSSEKQCNDAASTSYFEERNVNSKFDVPGRASCENQSDSKREASNSFLRKLSKMESDSRLPSFPTYNAAAEGRRKRIETKIKEERSKMLIFRDVGMDLDKPILSRDVFLVLKYFRYGMDFAIDNELERMLRYFNEHATNELKIIQDSKLMRGPPFLSRKRRHVSRQKNPTTSLMKPTPAVGGSAEGDVAEQEGSTVASHQQALQFQISSVFPHIRCAHTRQFCSPNAFSAAAASKLATLLSLSNSSSSFASYFPPMTGHEARGSCSKSYNAKDSGLFTTITPSMFRRPAVVILSQLGQKFGSQADIDWRRLAYSTTCPGLLPYIPLPAEEVGTAKSGTTNSQSRYGISRSDILGKDGSSVRAASSPRSMPIDVISLRSADVYKYGWVQRLYVNRFAKSLSPATPSEPGEQPSVDEIKNALLASSTFVGSQLLEPFYATLGLRNYLLPHVMLVDHEGIVRWLSGGLPDADEKAVFPSLLRQLELEYLKAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S6S8</accession>
    <name>A0A088S6S8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_180550</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697889.1">
        <property type="nucleotide sequence ID" value="XM_010699587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S6S8"/>
    <dbReference type="GeneID" id="22573945"/>
    <dbReference type="KEGG" id="lpan:LPMP_180550"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180009800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_180550"/>
    <dbReference type="eggNOG" id="KOG0144">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410044at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000955">
        <property type="entry name" value="RNA binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="182"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="333"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="350"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="372"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="419"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN97236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="436" mass="46119" checksum="9AAF308AA2629837" modified="2014-11-26" version="1">MEHAAAQTQSLYSSANPHSTNISTYGNTVSPYLSNNSPNAVMYAGGSSSNGGLPSPTSVATVYTPTTHASANQVIRQQAQRTAQQNMNQSQTSTTFSAYGGAAGSGSGSGFFYSTPPTQAAGAQPIYSANASAAAMFPIRGGSTSMSPAQMAPTQMLTPQTNVAAAAAAVWTSAAANINVGSKLFVGQVPAVCTEDQLRPLFAQFGNLLEIKIMREPNGRSKGSAWVRYESEESAQRAISSLNEKHVVPPQTNPLRVQFAAPSTNRMSQVSQPQPLSALSTIMPPSAVMQPQPQPNYATAATYATPQGYAGATTAYMQGQYTTSSNLMTLRTSPQQQAAVPPPAGKIEYLQSNQPGGLIYSTTSPTAVDAMQQQQQAPQQQQQQAPQQQQQQAPQQQQVVYTTGSQMRSVMYTPDPFGMTSQMTAAPPQQHNQWCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S739</accession>
    <name>A0A088S739_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein kinase, putative</fullName>
            <ecNumber evidence="8">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_190340</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="8"/>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698029.1">
        <property type="nucleotide sequence ID" value="XM_010699727.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22574088"/>
    <dbReference type="KEGG" id="lpan:LPMP_190340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190011700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_190340"/>
    <dbReference type="eggNOG" id="KOG0667">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:002125">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF17">
        <property type="entry name" value="HOMEODOMAIN INTERACTING PROTEIN KINASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="1211"/>
            <end position="1862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="356"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="509"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="621"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1063"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1309"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1442"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="356"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="522"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="631"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1072"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1309"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1449"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1498"/>
            <end position="1507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN97376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1875" mass="198479" checksum="F2B34F199A23E415" modified="2014-11-26" version="1">MSTSDRLTDAYHSSESSAKALSFTLTDAHCVKCRKALKASIAPFAASSFQASRAAMMDDDLTPGLADLDFTAVSAVCSPTFLQREFFEASITSESAGGSSALLQSVVNRRDISLADISRMRLEGCRARHTSFTATASLRGSTASSLRSTSALPINSLTCRMRDQAGIFSKTTSAATPVASQAPACSPFIGLGGSIYRRPSLSSARTSALDTSAAILQHMAYDTAAHVEAVCNAPSLAGTPSTTTSACDSVAPPPLQPTPHHLVHTDVSAHGGKVVECGNSIPLGVSCNGSDQHTSLLQVTHTRPYASAANSPSPLNSFSELELRNGQLSAGDFLRLSAQTSATCLASDAVVAKAASDSQHSSSLPPLGGPLSATRRQAHDTKDHRTPYPSEAAATLLEVIPTSTAAAATMEMARRTSPRQTRDVSVYNHDFQHIVPPEVKQALQRNMCPICEDDEDDDALLHDGLNVQRPPPLTSFANGAHTMHEDHYSLDTPSLYVYTRGVASRGSGAGTTISFPSGSPRAPSQLSTSPSAPALSAAASSIGAWHAGGTGGGKSIHQIGSGSAETMIAGLSISGTGVPFQTWKFPSLGKPSSTFSLRKTSLGEHGNAEALLGSAVGGVGPARQSAAPFSEHSSYPTRASLTSGSRQQQCSEYPLLNHNELQATSRGSTLTTVATPYSPVAAIPQSGADDVGHCATSLFSGVGCTHQTASGARGNSIHCTSGASRGLTQRAVAADSSSGTVGCSSVAADGGNTHKLEMVCTAYERLLCARLPANSVAAAFPKTLQTLISRNLTETVMPPLHPSPSAHSAPQAPQVAATTPVAAVVGFESASQGDVSPSMSYSGTLGRSAGYYSFGKRISLSHPNRQTLPHQFLGSTSNSHTVPSSPRMAMLSISAVADLIVASSGKSSGPNMTSSSTARMQRGTLDLSLLRRTESRPLLQLTLFLQSTLRSICEAQSRHTRTEREEVVGRGRGSTSTSLSTLTAAAVNVLPTAESSMDEYLHQYTFPEDALSTAGAPSPARVADVQTCEGEARASQMQMAGFMAIAETASSMTLASAVTTASAVSPARESNRTNNSSTHVPSSDSILQSPCLSSTGKRANVSSVPVNCTQDEQKQLTQLPKQTEMCIDPTADAAAAVMKSYVTLNNSPTAAADVSATYERNGGPPHRYYRALTEAERLVRHVHCVDGVEREVDNDSMDLVVYVGMHLMGWLEVVGLLGCGSFGQVFLCKDLRICDGHFVHPNEIEGEDYEYWNCSHAYLPFSSVDAVPTHRPLVAVKVVKSVPLLEQQSVLEAEMLVLIGAQTAPPSARAAEGASESATPTSATAAGDYNGANSPPPEDLRCANIAKVLADGICYGHHCIVMERYGANLYEYIAANDHQGLPMYQIRAIGAQLFSALSLVHEECHIIHADIKPENVLLALDFCRTTLRVKDEPLPRTVAVPTTKAPAGTASNSNSSTIPVTTKTLHSVPPQTTSARVVHGSQRDTSPNEEPPWHQQRTESMMPSSSTPAERSYITLRVGPGAVARQRLGLNGKRQSSNVLLDASFSEAAVAKDKGHGFCHLRSFSTSHATIVEHTDLPTPEPRRLQALNQSCGMLSSGTLLQSLGSGSFSTHSRFTMQAPAAPVEEAPAVPAASATSHLHVRLIDFSSSCYDGGPFYQYIQSRYYRAPEVIVGASYNSAIDVWSTGCLLAELLLGMPLLPGCNDHHQLSLIEEMVDLLPDSMVESGDNAGLFYTAAATVGDGSADTVLRQPRSFVLRTRENYLQISGGELLPYNRYFTYQTLQELVRHCPLTLEERRMSNGLQPYVSANESSAIPPDATPLPSVRSDMMKQRFLLFDLLKRLLQTDPTLRPTAAQALKHPFFSSSPPYFTTFALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S7I1</accession>
    <name>A0A088S7I1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Calcium channel protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_200490</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97541.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698248.1">
        <property type="nucleotide sequence ID" value="XM_010699946.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22574256"/>
    <dbReference type="KEGG" id="lpan:LPMP_200490"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200008700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_200490"/>
    <dbReference type="eggNOG" id="KOG2301">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2302">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271228at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001518">
        <property type="term" value="C:voltage-gated sodium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005248">
        <property type="term" value="F:voltage-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000118">
        <property type="entry name" value="Voltage-dependent calcium channel subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043203">
        <property type="entry name" value="VGCC_Ca_Na"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10037:SF62">
        <property type="entry name" value="SODIUM CHANNEL PROTEIN 60E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10037">
        <property type="entry name" value="VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN97541.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2764" mass="312845" checksum="366A78A023AD95CF" modified="2026-01-28" version="2">MSSLNNSRAQLSNSSRQLNPPHPTLTPNVRASTARRADPHDESAMPLNGTMQGSYPRQTLPPPLPLVHRGSAAATAAEDPAAFSPPSAMALSGSTPALPSPAQASRISSAKGGRQQQPELQPATPIVSARGATPEPQNTTTNAASRPLRPPTIPQSRSSASTPAPPQSPSLPLRGVAAAASLSRGGPGTVQSRKTSSAARSNSSLGASTRVSERSDRVEELMEIPLAGTQPIEKFFIEYNSAAAAHDDDGQPRNDNEVLLEQFAEYTNDDSFFSSSDTVIECDPQRLCKDPLRHRAIVSVHSTLQLRALTNGRVPEDTVWNNVTRTSWLYQIHNRAIALQYSSFFIFPARWTPRVMVYNVMHHWLMEVFIFLMILGYAIFQATWARYPDPHGGIHKPDYILWADVFYTCLLGFEILARLFASGCVLHKRAFFRSPWRWLDMAVLVLSIMECTWWQDLWNFTAWRLIRAIKCLTYVPAPVRMKLLAKSLLRSTNRLIYVTILLTYFIFFFGLLGLQLFGGTLHSRCVNTLTGSVTSQVCRTVATGRYSFYWGHHCGAFSICLADAFPNPHYNFRSFDDIGHAMLSVFQIMTFQGWSGLLQETNDAVAVMAFLYYYFTILICTWIVPSLYAGVFLEKIEKTSRLFALKQLDFFDRMLTEQRQRMSTMVRLGDYVQRDENGLVSCYPAYTAQEKDRKHLTNDDDTAGGSTGDHHKHAHRRKSHRRAIQAMKWTDEQRIQLQLALTRQRDVAEEAERKRGLQQASLSDPIVEDDGARIQQGAGRQGASLARAAQSETSPQSSKGCNDFALGGRVGAVQHHPAVYAIGNSHQSDLPFAVRQEVQAEQLRFLDPYTNGASTAKNDMYNSATALHTLMEKSRTSMPSGGAERAVVSHSHSASNARPLPRAPSTQSMSVVVARETAGVVPNRRAMPVHGSLSRASSMHSRSSLSRLHASMTQVPEKEQVEYVINDPEGGDFHYAKTLAQKVSIIRNIAHMFTEGYPRIISQYLWEHRMMQHRYGLAPLSYTNKYEEEALHRLRQRRARERAEEQEELRRNGMGHLIDDDDDDDAEVEKPWMRKEGLVAGSMSLIRMARNIRENAPITVFNYLMYFFIIANAVFNATRFDTMPDYWETGLFVAGVCFSVLFMLELLIRLLALGPGPFFTDVLILIETTFMIISLFQLGFSRANTASLFNWVRFLRLFRVIPCRPLRRVTRVLIHGFPDMVYALLFFTLYMLMWLLLGMSLFGSRLGRIDYNTSDYTTRATFLTFSHAAYAVAQAFSVNRDEWLFLSWSGARVRGGYTVLYFIATVVVAFIFRFFFIAVMTYAWQAQQEQEDYCFMSGSSHGRRGFRSRFARLPFFDFTVWRSFKHIHGGFDRRDVAPDEIYFVNEDMARQLRLVEAKDRYYRENYRQEKGEWGDMDEDSHMDGSDVYGSDGALVNGPRYVNIGGRLYRQPSLPATEMGFSEKATPSDRGQLRFARRYHAVPATTYASAQQSQQPASAHDALPEGVEGSLPPSRHSRRSMVNPLLTFRHSLSPAYQCTSMSAPSVTRVADSLAEERTNNANISLVPRLTKLGNARAIVAEADGETTAGYSTPEDVISESDFEHLLLPGPRLRYQSTVDDGRRVFETCLDCNTHMQMPLRAPPGVAQRTAAQLHAEHCHMAAVRSSQQLVLNALMGYARMQAEHEVTPTKQMVEVVLGQAWSCGMLLFDTIENLSCMDLPEKERMWDRMLEALELQQWLLGLHVGEEQVGRATLAYILAHQQRQEVQVQEKSYKNNWADRAFFLLSPSNPVRRAVSAVVCSIWFEIAVLCVIYAASVCLAFYTPSDGNRDFGGSYNSAKYKALHVLDNIFSILFVVEMVLRWISMGVVLPVGRAYFWHLWNIFDFFIVIISLVSWGRSDIYLRYLKVMRCFRILGPLRYWKWGSNSMSYVARTIWDSIPTLANVCLLMLMNYIVWAILFVSMFMNKLNYCSNTTIVSATQCVEAGYTWAPTQRNFRNFYESLLTTFEISTGAEWLDVIYSVVDSHSTVLSPVMNRHQYLGLIFIAYYYVSHFILFTLFISAVMYCYMLAKSATVDATGTTIEHQVWLRVQGMILRLKPKPRLLPLSNRVSRLAHALILNRWFEAFMGLILVFNMVTMSLEWYHMSNTQRIALDVFQYIWVGIFTVEVILRFTAHGLRLFTRWAYCWDLLIVILSYIQIGLNTTVTNQVPFNVNVLRLLRVGRVLHLIHLVLPFSTHFTLFYEVLKASVPGLISVTFVYIIAVYVFAILGLHFLGYIVPFGGFIDDKYNNFANFVNAIIMVFRLSTLQDWATMLRGSLDRGHYCARPSKRCGPTNWAPVYYTPIVICFFLLLSTLYIAVVLDKYVAAVHMLSAVTRLDDLRRFCRLWSKRDPNGTMWLPSALLPELLEELRLPLGVSNRRNRIEVLRLLREYNIPSHNGRVYYYEVLMPLARRVMAIAFLDAGDVHTAGSEGPKGIAWHLWERSLEALPASYNKVQPSSVTVAEQYAVTLLQAAFRRDRAMRNYFIAKSELWRRGRALCVERGLSYDNFGFGKTALAGPDPREEGIHRGFNIPKDATLANSSGGRVYADPVAARISAMREAIGSQKRATDEEPPTLLPAVYRSAIYPEERRFGPNAPGAIRRHERRDEKLGRKRAQEAYERQLCERSMGGSPVRTLAEYNEDDTFTADDVDVGVTLSKGTMESHPAPRGNQYNLNSKDVNYQPPLGTSPEELRQEEVVRRLNAAATAATASELLGGISSPTNSTQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S9D7</accession>
    <name>A0A088S9D7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_211630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698948.1">
        <property type="nucleotide sequence ID" value="XM_010700646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S9D7"/>
    <dbReference type="GeneID" id="22574985"/>
    <dbReference type="KEGG" id="lpan:LPMP_211630"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000006500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_211630"/>
    <dbReference type="eggNOG" id="ENOG502S278">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271469at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="271" mass="30380" checksum="118E45A3D87F946B" modified="2014-11-26" version="1">MIRFRGNHYKQLLTQLPRNLLVFDGHCLLCQARVRYVLERNFSFFSLLSYVMCRVEDDLAEGLDRHQIYFASLDSKEGANVRRLFFQRTPSSSAACASSSTAPPQPVLPVPEDLVLVFIEKVPSQTAKFLACVRPGGVAADDRTLFQNTTTAATYGRGVAASASTTSSSSTASARLVDAAETDLFVSTNYTAMCRVGMHLDRFLIRLLFRFLYCAVPTSMGDCWFERYVCCRRKNIWGTSEQDAVKVSGIIEGMVARRWVWRGVSSNPPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S9Y4</accession>
    <name>A0A088S9Y4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RanBP2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_221570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699158.1">
        <property type="nucleotide sequence ID" value="XM_010700856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S9Y4"/>
    <dbReference type="GeneID" id="22575203"/>
    <dbReference type="KEGG" id="lpan:LPMP_221570"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220019300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_221570"/>
    <dbReference type="eggNOG" id="ENOG502QWS9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="238521at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="4">
        <location>
            <begin position="527"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN98451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="809" mass="89989" checksum="512FC3A03A0668BF" modified="2014-11-26" version="1">MLNPCRGRLVEVQGRCVDAAWHLVRYYQADMQLVLELPLKHHHLLDDIRLVNLVTSASPNAGLLVSKELANGRELSLDVACTLLSVPCAPDVLRAILVCTLRTHTGTVDAQHFQRCAHALLSNDNFFSERTFALMHSLLHDVLLPSLRGGAARSGSFDFVSVRWTTLMNKWSRVYAKSGRGFDLHDCLEALLQAVPAAETKLPVSFYVRLLGAVLDATAAAESQQATKAGWERMKTVASDALRLFGRNPEDLRAVWVLLLKGALTLPPAQEDHRRLLEAYHLCAQRGHAAAVDRQSFLQVIRHVATAVSALPHPEVIQLVGDFCTFMQEQTSVSFLWLLDGVGTVLTELWRQHRLEAQGEAEQLLRVMKTLLRERHVSGVQLHSNPVIARALDHFQLGSAPAYWWICGCGEVIPCTSKRCISCLRQSAASWVCQKCRAIHHAPCKAQSCSCGWPNPRLVASINANVSICAKCGLVTDEGCVCARCKQQRQEGESTVTCAHCHATYSGNGLHCPQCFTPNPDKPLYLWHCVDCDDFNYSIWSSCRSCKTPRRTGALWVSFVPWKCGCSALNHPCRLTCRRCGTGAHHHKYTCAGCDARISLHSLRRVLLTVDGRALSLHLCPKCQCPHPRDDLVLYSPSFSRHCMLCAHTVKPSSISTSGSFFHCNAVQRMNEHYVFRCSHCDHTGLQTGYHCQRCHFPRPEMEALLRDEAGAAPLNHVWRCLHEAEDAAPCGQWNYGWCAHCLSCGRGRPDSACECRAKAQMWTCETCGKPNRPIDVLFCFHCKRGLQPVLACSTCGLPHLSYACRVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SBS1</accession>
    <name>A0A088SBS1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[RNA-polymerase]-subunit kinase</fullName>
            <ecNumber evidence="2">2.7.11.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_260060</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.23" evidence="2"/>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699828.1">
        <property type="nucleotide sequence ID" value="XM_010701526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SBS1"/>
    <dbReference type="GeneID" id="22575909"/>
    <dbReference type="KEGG" id="lpan:LPMP_260060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260005500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_260060"/>
    <dbReference type="eggNOG" id="KOG0659">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="240895at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070985">
        <property type="term" value="C:transcription factor TFIIK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001108">
        <property type="entry name" value="Protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000878">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF0">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="4"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN99121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="296" mass="32540" checksum="307B063BC4343A22" modified="2014-11-26" version="1">MEKYTLGPVIGEGQFGSVRMATVKATGQTVAVKLLHVPRLTEGIPHPVARELLIASRLDSPFLVKTIEITPYGSHMAVVMERCVEDLACVLRKCRPTHPLPLLLTQSYLRMLLTGLHSMHASGILHRDVKPSNCFVAADGCLKLGDFGLSRPLGSDMSHEVVSRWYRAPELLFGHRRYGYEVDVWAAGCVFAELLRGHGRPLFTGDGDINQIAKIFDVFGTPTGATCNFYRQLPDWEKVYFEEKKGTGLPALLPFVPSEALDLLSTMLALDPASRCSAAEALNHPFFGLSNIALHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SBW5</accession>
    <name>A0A088SBW5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nuclear transport protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_260470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699868.1">
        <property type="nucleotide sequence ID" value="XM_010701566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SBW5"/>
    <dbReference type="GeneID" id="22575950"/>
    <dbReference type="KEGG" id="lpan:LPMP_260470"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260009500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_260470"/>
    <dbReference type="eggNOG" id="ENOG502QW7H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="246407at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF7">
        <property type="entry name" value="IMPORTIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="896" mass="96088" checksum="E8FA624084BF228F" modified="2014-11-26" version="1">MQERFLGVYVRLLLVDAHPSVLLTRKVSRIVALMAKRGSRNTQLGALPSAIQHVVTSYVSELQRASAAQAHARVTYVLLYLHVFLKEMQGCRVGSVFEDVCRACVAPLSGIFTLLPSETSMLEQYDLSLYLFKCSLRVFGRGVFDPAFCHFLLASTWRLAAGLGQDAPESPNAGRRQRLLEYALKTHEATVVFFPSRLHELGIPFFVVDDGAVTGCASSPSSLSDSPEHTVLRLLSAVISSPVGNVVSEKAVCRALRFFTLLLSAEDGDAFIAHCLQRYVTSAYFALLLQHLVGTYLADTTTPEALSEWSRHPEEVAAQLDVDMDDETSAMSCAEQLFLALTGSTVCASASLTTAWAVVNQLLQEGNVGPVTAALHAIGIGYYTMASEDASSYLHFLRGKVLPLLDPTTLALTSPFVARRMVWLVGMWCESVTRTEDRCAVLSALEGVLHHAAATQNIVLLLVALKSTENFVSDNRFTLSDLPATLVDTLLHTVQELLSRAQSPTTIKSLAGLVHVLIEKGAVQTQGDALVRLFLPPVLAIIKSYEVQATKADVRAAAGLVVDAGGAGDEEDGEDLVSSLSMLLECLGSSLRHGESDAVIWSLLPCVIVPCTSPGGAATAWVEDNAWELLRVMAQSSRTFFIPTAAEALQMALQHTARDFAMLPLVFRVVYTLLLLRQEGPEDVVSPAHLETWATTLRESLSAELCSAVAATTFAVVRTSAGPLRAVLCQHAAQALVRSSDVQSEQHTLPLAIALALSFASANGGEEQQELAAYIHAAVQSCGPSASYSQLLEQVVLLLDVSPSTLASCSLARLLDMLCRTSTVPLSEEDEAMVQRAIEGVAATSGATASATGADDEDAEDRAAPEMLLELLGDEDVPETSPHVARAMTTFAALLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SC05</accession>
    <name>A0A088SC05_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RNA-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_260980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699918.1">
        <property type="nucleotide sequence ID" value="XM_010701616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SC05"/>
    <dbReference type="GeneID" id="22576001"/>
    <dbReference type="KEGG" id="lpan:LPMP_260980"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260014600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_260980"/>
    <dbReference type="eggNOG" id="ENOG502RXBG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276381at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="410" mass="46064" checksum="8FACD729C0500DE6" modified="2014-11-26" version="1">MSHQKRPQLTLAVPETLQVLDMGLDFRSYLSRVDESGVPILGNVISYGVAKVPDIFEPTIGLLVTVLHLFSQSGSGSSAIMWLKTYDTVQKVYLEQQEDHADTDGAKYAQAARDFIASQLNLAASPDNRVITERLFAFLDYQSGIRGPQAPSQRKIPRDPKGAFCNLHLADHKCYQEFSCNQLHLHEAGPVRHRINFLQKLAEIMMAEERPRAEVVKRVKDSIFFARYGNKVTVRCHNNWIPFFKTLYTDGRLEQAFRSNMYSCQNLNCTDEHCKGIHPQDRRVPPATKPIDLHNAQQVALELDEEAEHVVSAVEKAKSAPELPPAMTLASPLSVLSPTAELWRNTVRDYVRQSGIPQVEADESLLRTLQDTKVTGTPLSTSERMTPLLVELDNYAFNSSQSSINSETRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SFE1</accession>
    <name>A0A088SFE1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_303050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701327.1">
        <property type="nucleotide sequence ID" value="XM_010703025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SFE1"/>
    <dbReference type="GeneID" id="22577358"/>
    <dbReference type="KEGG" id="lpan:LPMP_303050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300035200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_303050"/>
    <dbReference type="eggNOG" id="ENOG502S08S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="251680at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="338" mass="36397" checksum="DCB82FFC3770166E" modified="2014-11-26" version="1">MAAAQQVANAFTVDFVERVAKNTANIADLYGRHATLTVNDFELGISEVCDDYVPIAVQKWVVSLQGSRLRVDSVNAAPLYGGVNVFMTMTAFGEMQQYYHIVTTLESFQDTYGIDGYYVRHQVIARIGAVAPERPVPEPTSALAEQPEAAKKSKPATPEPDAVPAAQEPKPEVTEEPASAATPAELEAGEAKPASAPVSSKPKSWASLVSRAPVKIAEHKPVRVVAHEGGKKPTPEPSAPAATTPASKRPPPRERKASETVGDRLMFNTTGSVTDEEIRAALGPMSAHLVSLRNNSAKGHVFMDFAEKVNVFDELVKTQLVIGASKVKMSVFRQRARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SGJ0</accession>
    <name>A0A088SGJ0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MORN repeat-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_320450</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Assembles a suppression complex (suppresome) by tethering SIRT1 and MDM2 to regulate composite modifications of p53/TP53. Confers both deacetylation-mediated functional inactivation, by SIRT1, and ubiquitination-dependent degradation, by MDM2, of p53/TP53, promoting a proliferative and cell survival behaviors. May play a role in the regulation of spermatogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
            <location evidence="1">Acrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO00932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701732.1">
        <property type="nucleotide sequence ID" value="XM_010703430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SGJ0"/>
    <dbReference type="GeneID" id="22577786"/>
    <dbReference type="KEGG" id="lpan:LPMP_320450"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320009300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_320450"/>
    <dbReference type="eggNOG" id="KOG0231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0245">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270720at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001669">
        <property type="term" value="C:acrosomal vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052472">
        <property type="entry name" value="MORN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46511">
        <property type="entry name" value="MORN REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46511:SF1">
        <property type="entry name" value="MORN REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Kinesin motor" evidence="7">
        <location>
            <begin position="17"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="98"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO00932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="718" mass="80576" checksum="5A0D06C1C0DA1634" modified="2014-11-26" version="1">MRSTDSPPTIHPPVVERLRIAVRERPASDEETPLTQVQLRTDQDKLIAFAPHAADGLMYDFDYFYPQNARQNDVFRTIGLEMIDLVMGGLSANCIAMGYAETGKTHTLFGSPNESGLIQDTVRELFRRLEAQQDTHEYSVGFSYWEMNCNGVHDNLAIDEAAFADGSAAASGTARDHAVYRDGFGRLYLSHVAEIPVKDFGDFEVLLNQGNERRVRRGYARQFRWHGFVQLSLMTLDRHAGEQCVLRRVTFVHTKGSERVGANRAPKQVLREGSQVNVSSTLLNAAVIHSLEYRAKRVGQCHTQAQLHRLIQRSESFFMECRYTQLMSQLMCGHEACFVIGCVDPLSYSETTETLENLQLYRNLVAACVPVLTPSERGRLLQQLRAMETAMGREEVLQLMHLGTSGRPRTEQEEALISLRGQLEVWGGGNAGLAQQSCTLKDTPTPCGVDADDRSIRKIVFLNPAKTATYEGQWKGAVFDGFGEHIQSNFKYRGEFRSGKREGHGTLFLRDAKESPYRRVYEGEWLGGRRDGRGTQWGRDGEVYEGDFAADERHGLGKLYLANGDVIKGNFSHNKCEGWAVLQQRNGDWFEGYWTSGEREGPGVWHYVSRQRCLRGEWHRNVAVLGTMEDDPDKIDDSTGPFIPRLGLLNSGDILAQQRKRLMEKRRLEFAAAGKTWVDYAAMDKRCTVPTAAAATPMATSEHAATADARAICGLEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SGS4</accession>
    <name>A0A088SGS4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PTHB1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_321310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701817.1">
        <property type="nucleotide sequence ID" value="XM_010703515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SGS4"/>
    <dbReference type="GeneID" id="22577872"/>
    <dbReference type="KEGG" id="lpan:LPMP_321310"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320018400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_321310"/>
    <dbReference type="eggNOG" id="KOG3679">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262646at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034464">
        <property type="term" value="C:BBSome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028074">
        <property type="entry name" value="PHTB1_GAE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028073">
        <property type="entry name" value="PHTB1_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026511">
        <property type="entry name" value="PTHB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055364">
        <property type="entry name" value="PTHB1_CtH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055363">
        <property type="entry name" value="PTHB1_hp_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055362">
        <property type="entry name" value="PTHB1_pf_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20991">
        <property type="entry name" value="PARATHYROID HORMONE-RESPONSIVE B1 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20991:SF0">
        <property type="entry name" value="PROTEIN PTHB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14727">
        <property type="entry name" value="PHTB1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23339">
        <property type="entry name" value="PTHB1_CtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14728">
        <property type="entry name" value="PTHB1_GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23338">
        <property type="entry name" value="PTHB1_hp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23337">
        <property type="entry name" value="PTHB1_pf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PTHB1 N-terminal" evidence="2">
        <location>
            <begin position="3"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="PTHB1 N-terminal" evidence="2">
        <location>
            <begin position="168"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="PTHB1 GAE" evidence="3">
        <location>
            <begin position="537"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="PTHB1 platform" evidence="4">
        <location>
            <begin position="629"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="domain" description="PTHB1 hairpin" evidence="5">
        <location>
            <begin position="736"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="domain" description="PTHB1 C-terminal helix bundle" evidence="6">
        <location>
            <begin position="842"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO01017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="919" mass="99791" checksum="1E62138838A03A87" modified="2014-11-26" version="1">MGSLFQLRDFWYTSFPEEEFSPSAVTLADPDVSALFDKIVLGSYQGVLRIVNPSAFEGPMQPGDVLLEKKYTAPILQLDCGPFRPFRAGAPSNLLAILFPRVLMFLEITAQGSDNSSTINELNPASRDSGSSDLAAEASASTTADAQPRQRYRHGNNSNVQDACSSFKELGAFYTVTVQSEAHLQSTAYNFVCGYFGSSDYRMVCVQSMDGLLTILDYSGVLYRTFWPSNQFLIPGPMQYSVHRDALLTCNTSMFLLSYSFSSLVLSSTTEDVAITMTGTVTAGPSSGLCPMWAFNLGEDAVDIAVCRLTRGLPREEADIVVLCTSMLYVLNESGEPRMIRRLDIEASTLCVYSLPSIQYDNLLVGTFNGLVQVYSDTELQWSAAVASGAAPLYLTVATLCGVEGMIVNLASDSSLSINYLGTDPVDQRPQSLETKLTSYPELVHDLRQWEQLIQQYRGGAETPAEDGDPDDLLAVPEMTSAYAGAKLKKKCGAGTAEEEVASSVIIAPTAPSSRQAAVATPLSITSEFASIRTDDNSAMFTVTLQTLNNHRVNEVMLVLQAVPPLLVTPSQCTIEQITPDSSVQQTFTVSAIQDRDLIIPSSLEVVVAALYRGERREYETMEHVALAPLLLVARPVAPVKNTAFLLQLHTNQSSPPSLVEMFSDMVPFGNITANVLSLQYLNGADATVLVSKNAARFKLQGSTMEGLWLLASELTRRVPLCCGGAVELKFEIPDHLPVPDFLAVVDTHWAIRKEMEAASAALDDAASLFRAVEKRLLARFRDRSPADATAVEVLFQESYSLLRERADAMTRAKTRLRQASAMLNCCAQLFWLFLEMKSPPLAAQDASILSTLFRCSVSDDNDGGWEEAAETVLATVLKLKRKKVASNTLGVSSSTANLKKYIGALVSVVQSGQSLGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SJM6</accession>
    <name>A0A088SJM6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_343950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702817.1">
        <property type="nucleotide sequence ID" value="XM_010704515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SJM6"/>
    <dbReference type="GeneID" id="22578900"/>
    <dbReference type="KEGG" id="lpan:LPMP_343950"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340046800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_343950"/>
    <dbReference type="eggNOG" id="ENOG502QSAH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1914839at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24142">
        <property type="entry name" value="ACL4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF10">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13428">
        <property type="entry name" value="TPR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="311"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO02017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="337" mass="37666" checksum="4883C14BB8D5994E" modified="2014-11-26" version="1">MDTNTLLALAQSAVDAGNVKAACEFYEVALAKSPNSDEVLEAYAEIMIHHVQDIPRAQKMLRHAISLNPNQGYVKYLNLAQLCEAEEALKCYEKAYEIASLMLHGCRKKRMRKTLEETMATMCCAVAELYLTDLCFAENAEQQCEQAVNRALQLNSEIVEPHQLQASLRLSQCRPDEALQSLRRAVDVTHRLGEEYQPTYESKIELGRLLMQVDPAEAFQFLLEVLQYGDNNPYVWFLLGESARLRGRYVDAARLLRRARVMLVVSGGDATALSEVDAAISILVEEMGGPEAAAQVKDLDHPYPLELLQVEDDQGAEDDDDDLAEPEHEACDGEDDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SJR5</accession>
    <name>A0A088SJR5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_344300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702852.1">
        <property type="nucleotide sequence ID" value="XM_010704550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SJR5"/>
    <dbReference type="GeneID" id="22578935"/>
    <dbReference type="KEGG" id="lpan:LPMP_344300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340050500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_344300"/>
    <dbReference type="eggNOG" id="ENOG502SSZM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="263508at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO02052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="155" mass="16943" checksum="909C8CF758CF23A4" modified="2014-11-26" version="1">MADTEVVGDAGACASYRDEALFPYCFYARLLQTQGAASSVPPATLSGSPHTSVLLQAQKLRVDEDDVAIRLAGRLRERTARAHGSLQGLCSVPPGNLVAPFCDPTVEEQQAQLHSELTAFLLEVRRKNLASVQLRHQLQHSRAVQARLHDNGRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4X9</accession>
    <name>A0AC62A4X9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3520200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="XUY36852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="423" mass="45567" checksum="78DA018FEFF47D76" modified="2026-01-28" version="1">MQPGVSEMARGSYRTLHTSASAARRPKTDYGILLEAKRRSEGTINRKSASTRSCAAAEQAGQRLSSPRRRGVREAGNVIHPTTTWTQRTTSLLPTPRGQCTPMLQNGRTSPRGEQHVGRAVSDEKMDDAASALLSELQQVVVRVSHQMVDERRRAAQQRKQIDTLETIVAEQDAMLDALRTQHNAAQYEKCYQNELRCRGVDSVQPKGYNRESCRTSEWRISAAQVDDCVCAEFRRLSLIYESSPFSGFDEVSPIIAAVLRSLATQVLQLRCAARENEVKASSLSRGESSFAFQLPAGSAPLVTAPAVSSPSVMLSFNRHAPAANCSNASAVDRVTPTMAPEAQTKASVSATPAAGPHHASLGSASLTNGEEGKLFCVDMDTGMNTTVRAAARPASEASVSVSNSVCEDAASILSDIRARYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5H7</accession>
    <name>A0AC62A5H7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histone H3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1620390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="XUY37050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="66" mass="7238" checksum="D87F239EB5F19D1A" modified="2026-01-28" version="1">MPCARCRACRRRGGPALPEQRDPGDPGGVRCVADGCHEPGQHPREACVTVRPKDVQLAVRLRGERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5L9</accession>
    <name>A0AC62A5L9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Elongation factor 1-alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1720040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="XUY37094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="449" mass="49058" checksum="C7CA18E3C4A6A3F4" modified="2026-01-28" version="1">MGKDKVHMNLVVVGHVDAGKSTATGHLIYKCGGIDKRTIEKFEKEAAEMGKASFKYAWVLDKLKAERERGITIDIALWKFESPKSVFTIIDAPGHRDFIKNMITGTSQADAAILMIDSTQGGFEAGISKDGQTREHALLAFTLGVKQMVVCCNKMDDKTVQYSQSRYEEISKEVGAYLKRVGYNPEKVRFIPISGWQGDNMIDKSESMAWYKGPTLLDALDMLEAPVRPVDKPLRLPLQDVYKIGGIGTVPVGRVETGIMKPGDVVTFAPANVTTEVKSIEMHHEQLAEAVPGDNVGFNVKNVSVKDIRRGNVCGNSKNDPPKEAADFTAQVIVLNHPGQISNGYAPVLDCHTSHIACRFADIESKIDRRSGKELEKNPKAIKSGDAAIVKMVPQKPMCVEVFNDYPPLGRFAVRDMRQTVAVGIIKAVSKKDGSAGKVTKAAAKAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A685</accession>
    <name>A0AC62A685_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amastin-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0820100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="XUY37290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="187" mass="21266" checksum="68964CA9A43824D5" modified="2026-01-28" version="1">MEFTLVFLLYAVVQFIAFLFVLVATPLDMLYDKNGSRFDNRPCVTLWGTKDECYGLTYEMTSDEVWNVCPVRRNRFRAAQAFAIISIFVYGLAAVLGFILLWCCSHLRFVCLALNVTGIVTVGFVWASILVTYYKTEFPCLRENLYTVLGSGFVLLVMAWCLDIINIVLLLLLWQAAHPSESGETKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6C3</accession>
    <name>A0AC62A6C3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Surface antigen-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0920270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="XUY37344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="125" mass="12530" checksum="848E87B86961EB71" modified="2026-01-28" version="1">MTSTRNKFLLALVALVLLATYAAAVKGDCSVENCATCLEEDATQCAECNNGYRPTDAGQCEAIPCDVPNCATCAAGSTTQCAECNADYQLTTEGQCVAASDAAAAPHSGVAAVAALAAAVVAYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6H4</accession>
    <name>A0AC62A6H4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SLACS-associated protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0220240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009371">
        <property type="protein sequence ID" value="XUY37409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1049" mass="114262" checksum="B688EC410D49A9A5" modified="2026-01-28" version="1">MYPDTAEQEEEDTGSAPRSAEPRTETHTPPTQPPGTEGEGEENDTAESANTEPDQTVEDVSQTSDEARHRFHHGENTAAQQTGTIHCPVCPRTWTSRARRQQQTSHLNTTHAREVVRVDALKATGVDRCLSCGEFVIASGNARRAHGQKCGEFVTRAVRNQKRARTEQSTPRQDAVAEPTPETPPPPTRHRTRPTEADAEWVQEFPATIRTLRKQEWGHWAEAVGHTLLGYTAAAAAGRYQRQLALTELVRTRLAKPRAPAREEDESHQEEPSETPREGGRDEPYTGHAGATRRANTEEHLPTRDAHTAEERRARRILHQLSLGAVGKAARTLFQAQLPRARASEALDQLRTLHPQEDPAGYPCPPQTPFPHGLKPEKVRNVVLKRLGRAAAPGLDGWTRELLVPVVENAALLAETTALMQDILAGNVSASFAFRLRACVVHPFLKEPGSPKVRPITPESVWLKIASHLALDAVEKPFRDIFQGWQFGVWGDAAEAVTQIRETYASESADTLVALDATNAYNRVSRAWVLRAAYRHHALHHTVGVVDLSLGEPGALGVYEGGRRVEQLWSTRGVRQGMVLSPLLFATAVAETLRPIMAAHPLAKVTAYLDDLTVVGPRAAVQAFLDEAGPALAATGFDINPAKSHHLSKSAAPEPVSVAGVVVPLARGVVRILGAGFRGSGAPVDEWVWEKTRPYEAYFTALGGDELPRHARMNLLRASALPRLTFLLRTHSTDELRDSAAWFDDRVLHTLSVLAGGAPIEDAAALLARLPLAMGGCGLRSQLAISRFAAQSVGRKGAQKAHTHQLDQHNLEALKTLLPEPALEIVKANTAPGATRALADPALHLGDFPFEVLVRQRLLLRVLRPEVRCACGADADNAHANVCPSVPGGPRIQRHNRVLTAIEAWAKRLGFAVVAEPRVSSTSGERLDLSIAAAGGTFATDVVITFPGRARSAQQNPLQQAHAAKKRKWGDWAAETGTTFAPVSLESTGGLHKESFQWLLAVAGSANFPFSTRTAFEELLSCISRALHEGNAYVFEAVRAHWARRLLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6L5</accession>
    <name>A0AC62A6L5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Surface antigen-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0920296</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="XUY37348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="197" mass="19750" checksum="FFE0ECB643C9B829" modified="2026-01-28" version="1">MTSTRNKFLLALVALVLLATYAAAVKGDCSVENCATCLEEDATQCAECNNGYRPTDAGQCEAIPCDVPNCATCAAGSTTQCAECKPGYRPTDAGQCEAIPCDVPNCATCAAGSTTQCAECKPGYRPTDAGQCEAISCDVPNCATCAAGSTTQCAECNADYQLTTEGQCVAASDAAAAPHSGVAAVAALAAAVVAYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RH40</accession>
    <name>A0A088RH40_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_010630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009370">
        <property type="protein sequence ID" value="AIN95163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696705.1">
        <property type="nucleotide sequence ID" value="XM_010698403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RH40"/>
    <dbReference type="GeneID" id="22571792"/>
    <dbReference type="KEGG" id="lpan:LPMP_010630"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_010005000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_010630"/>
    <dbReference type="eggNOG" id="ENOG502SM22">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267989at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="792"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="980" mass="103883" checksum="7ECC4DFA0C302FC8" modified="2014-11-26" version="1">MSGAKTKPPRREPYRPTSSFTPSAASQAAPVESDGIDSSGSPALPPLPLDPQHRDLTGENSLSHTTAAASHAPGSAVGRASSELLQNSTNIVGRQSRSSSPDLGGPSQYAIPQQQAGAAAISAFATVSVPLPSSVSDGSVSDTSQTCPTPTEPESRTTTTLFPPPTILDITEKGSRSGQGPVTTATEAPTAPTVAGVESGRPYVYDLSINSTEALQAAAVLPYWTSSLHNMLASSLPTAASAAVTHVATHSNSVSTSAGSGVCEPYFASRASTTQRTIQHALVHVLQRERVRSFITRALHRWLLHCILRLRERQYDGREAAAGMAEREVLSRTSSADQRRQEEQPTPVAATRCALYRCHHPLTADTSRLSSAQAWESPAALAGVLTATTKPTGKTTAPTPLPAWIPVGGVSRAARCRVTPIDEGDVDDEDGLHNVDDDAEVPQHTELLQRQEQQHRRGHHCSGDSSSLSDAAAYVDSTYARTGRVAVQGRLLSPHPANPQHRSRVAPLIGAPSRATSIARSLSAASNTSFSQSLGREVSFTPVRQSLSWSFQALLQPQRHDELLGTSLPTTPTTVSVPEVSTLDAAGAAAGSAGVIRPTTTVAGGAAAGAAPATVRRKSVVRHLFSTMSPLNMSPYQSSLNILSSGGGSATPSFDWPHSHSPSDMETTITREGHPLRLHRARSSMGGGAGLIASDSEERSRSLPIYTLQGRQSRGSRGPSSAWGTLRGCHSTLSDSTTPMLATTLTTVPQLLASETEERLAMQAREEQRRLRLQRAMSAVTDHLMMAALNHRSSERGLHPSLRTSAAASPLPEDSDDSSGGSCARRLHHRNDDTREVNLLHTYTVKEHYGGAAWDREAVIGSSTSTRLRLDYDSDGVDTPRHLQRSGCAEEDGHLSDVTDEHVKQSLSCDDEAIDMATALSERSMQALASTSQWGAHVLGPVTIMTSAQENVDQVTNITAAPRVPSPALQRGAYHHSGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHJ8</accession>
    <name>A0A088RHJ8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein kinase, putative</fullName>
            <ecNumber evidence="9">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_020450</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="9"/>
    <dbReference type="EMBL" id="CP009371">
        <property type="protein sequence ID" value="AIN95225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698190.1">
        <property type="nucleotide sequence ID" value="XM_010699888.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22571855"/>
    <dbReference type="KEGG" id="lpan:LPMP_020450"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_020009600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_020450"/>
    <dbReference type="eggNOG" id="KOG0581">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF56">
        <property type="entry name" value="MAPKK KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="583"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="613"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="1043"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="35"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="338"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="660"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="736"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="834"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1021"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1367"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1422"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="664"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="742"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="834"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="866"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1383"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1395"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1427"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="1072"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN95225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1448" mass="156662" checksum="BF022197A349CDE8" modified="2014-11-26" version="1">MRTSGDSGRRESPIIDETNTHPTVACVEATPTLGQTSYAPGMNQVPGVGETGKGPSSIHRKSHGGVAGSMMTVRSRIATSQNNHLSEGMGPQLDAEGPDCEDCEKLGGDGETQHSYSLTSRSCRRSDISIDAFPPHRELSGHGGAKGEQVQIDPENIEKSASTPDQAGVDSTRVSIDSYNHNASVSTGVAFLTKAEPVVVSTVYNERGAGSRKSSGEAEKSMQSLHQQLCHFSAGKNALRRRSRDTSPTALIASPTVPVVRVEAEFPESGWGGGSGSGDVAEVKVSNSLSAAVACAGRLLDTNLAPSDGVTTNTRESASRSRRSAQFLSEMLGTSEKALGGFSTRREGGSGNMDSAAAVSNPLHHHNNTSRRSDTRSTSDTHYAYGNGVTGTQSSGARRELPARSVENLAGGSRGQYHTDGLADWRSFGSYRGELEWLCVPSLFYLFANIIKWNELRLQRQSSRASLEENRARLSDASFSLVSNWTPNREQELYMLEDRISFSVFELKGVYLNPLLVRWSKPKLRSLVADVALTWEKEGPYSAAFDRASSRLFDAISTEQACQLRSTCLFLVRQWLGSAQHRGAVTCVLIGLLIVSILCIIFLAVFGRPQVIVCIALSAMLSVAVALMYAVAVFVLHHNTYADAAAKYFREEVVCAAQKKMEEEEREEEEEESGSGCGHGGAAKTPRDAAGTSGRGYTAGNDGMDANDEYMEDETSLVVRNLRALTEGSTYPVANAPPYYRLSDRPHSGKHGSDGGGDALEDDMTLGDENYAFLTTRSLQAGGTAKQQFEGYREKTPLLGCMAFEQHQAHMGQHASHRAQACMSTTQVLRPTEQAMASSTSGATGAQARKKTADSWGNDSQGELTRGGRDDEKGVMQRQPPLLKLSELPENFKVTALLFCGNVGVLSQVAPSLWERNFVLARVSSFQTLDSTFKHDSERFKVILIHAPDVPEGSAALETALSWLQVEKRPVFFFSCSPTAYPVSVPFSSRLLVPFSTTVLNALFQAGIGVESELSCLSFPVPQQEQERQGRQSPSQPFQVPPYTLGRRLGGGAFGNVFEAEMEHTGAKCAVKRMYLKEESNEDEEQQVQPGYSRVAGACVGSTGPLAAGATFAGSTGAAGVEEETGEGATAVGSQLRDIAQEVEIMSSLQHPNIVRYYYCERDDNCISIFMELCTGGSLSSLIHSGKLVSPPEIKHLLREIISAVSYLHNMRIVHRDLKPDNVLFRQGHVKITDFGTAVHKHGGGLRLIRGTFAYMAPEILVGDPYGRACDVWSIGCIAAEVLSVELPQHALGLPEMCEYYRAMGENSELAIECDVPGVRDFLLACLQRNPNERSTAARLFYHPILQARDTSIHDWMVEVVARRHRTQQQQQQQAFHRNGLGSRMGGRPGGSGGNHQASSNVPNNNEGMRCVSAGVDFDLHSGGGSAQSLDSSKLIEQQSSPDSKLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHL0</accession>
    <name>A0A088RHL0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_030060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009372">
        <property type="protein sequence ID" value="AIN95240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700948.1">
        <property type="nucleotide sequence ID" value="XM_010702646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHL0"/>
    <dbReference type="GeneID" id="22571872"/>
    <dbReference type="KEGG" id="lpan:LPMP_030060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_030005500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_030060"/>
    <dbReference type="eggNOG" id="ENOG502QSUH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270270at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN95240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="830" mass="93225" checksum="3288C6C437157B25" modified="2014-11-26" version="1">MEEQELSKIIINEAARCSQGRLDSESTAKLARFLSDAKGRNHVYQCCLDLAQDPGRRPRIMMLLVNYVQSFPPSRQCLESIKGFCKAHSSGDVSQDVLKLVDALLREAPLEGLASSIARSSRQGYASELALLADFSATAPGSGSVPISAVPYMKWMSVSVKKNEGVKCYSEVMYQRVWCPPYVDQFPLLCLESTVVRQTSIMSTFSANYKVNPNVMQATLFFMKQLCDGYVTKLHLSEPQLHFRSVTICYLPMLLEMMESDYLCVRNHVYDFIFNLGVHVQLIDPAGVYPGCTEALEQEVVWMVLTVVERQAVLKICDETTWTAAAKCLLAVVPPSYRHLVDCRVLFQVLQLPGLWELHPETFTILAQAFARSLLSNKDVDVAAADNLVVDEVAFAKLGSSAMSDILTIYRHCTTPGARKALFQLLVACAARRQGMHGARSGMRASSQLSAEARAGAFSDLMSVDFFWHTYPLLYYMSEAVQRELPRRIADGLVKSDFDGTKKSWNVVLPLVENMLGLLAEDAELEGYMQARFRAIEVLRRKDEEAFLAALQVLLDEVTETVPLLLEGHRDTNDTKVYTAAWRLAFVSLRWSSRYLPGDAHCALTDKLVRNLVFYKDGRGRIGNRARVGHMCASLLFSLNLLCRTSPQRDAVTFRTVLEVVLFDRGDTIDIRTAMALYHHLIEYLCVPTRSSFHLHTANDVSDVSTMVIRERALCISSAAVQFVGLRMLWGMYRSLEQSQAAAVCRARHVLVLLLCHQSSDRRGVEVRTWRTVLSDPYPPVALLAAEKIMHIFKAEEKPSTAAEINGDACRDVYHDAMRILEKGERKRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHP3</accession>
    <name>A0A088RHP3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_030500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009372">
        <property type="protein sequence ID" value="AIN95285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700993.1">
        <property type="nucleotide sequence ID" value="XM_010702691.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22571916"/>
    <dbReference type="KEGG" id="lpan:LPMP_030500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_030009500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_030500"/>
    <dbReference type="eggNOG" id="ENOG502S7PI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267501at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="683"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1120"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1196"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1383"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1407"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="711"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="985"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1284"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="362"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="735"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="811"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="827"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="850"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="882"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="897"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="933"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="951"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="989"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1035"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1045"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1062"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1326"/>
            <end position="1340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1436" mass="155537" checksum="C9FBB5FAF9106541" modified="2014-11-26" version="1">MKERTMATTAAEATLTTCSTVLHPSWTVPVEPSKRRSDSYLMDKVIAASLSKGAARPVSYPVCAARSEHHSTHLRADGVCRGGSCSARWTHRRRRTQRLTKRATVWVLYLLLPLLLYNSTPPASPRLTPVRAATPAAITTFYAPFISVRAVQYNLTLAFQTSDYVDNNCVVGWMTTPPSPTPLQTRSADARGSLAKEGAMAPTASTASVAIINVSACPYYPMWSLLAAEPPSFEETSKVFGGKVDTDAASHARVGGGKENLTSPRERRDRAAATVTVPSAERATYAVPDDLANVLWGPRNALAYYYEVLNTDAFFFMLQGCTIRISIDTDVPPAYPYNAFQRYADTYTLSVSATGGDGALNGHSGVRGSLSSSSASTRNNGTEGDGDGDEVGPDVTLPTVFFFWNQPRLHCTYNAPALMSMMVDLSNQQQQQEDPMQSPPGNRLPRLRAREKSRPTFRKDDAVLAEASTQLTDGEAAEDPLTASSTGPVYPSCTANMPSPKNILPSSDLDELLTMNYMQLSSTVVVKVFSFDVWYQFTGTPLPATLAKGRIMTTTAPASATYSAVFSSDPRARSGGGSAGVPTDASIAGQPFNLLADPEKVCAAPALYTISLNSLLARASSWGLGSVTDGLPPSVTVTHDYPAARVIAVVAQCSGVPLSFSVAVNFVNPGSYPGSGQHYATSIIYFFFLVCYALLLVVFLIMIVPCSKRRRQRRGSGAGGGVKSTSDGPGQATEANEKKQSRAESDQRTADKARSSDTHGRLSRSAVARTGSPDGHRQDDNRDEELQAMSDSKGQAKRRATAAALVDKGKAPSSPSLSLSSTSGTAAQTRTSTQRNTTGDPVNGAESKPLHGKMGKRGGHQLRGGALQQHHGQLVAERHNGSNEADNSGPGSSSLHSMDSNTSRMSSSDSDDAQDINGGSSEAQREAEARGGASRRGHVQSSRRSRHVTPSSSTSNDSDCTSSTSDSTSEDDDCCAACRRCRRRKQRSVGREKEKQQRERTRQCRHGLSYSSMDASDAEWNTPAGDAYDDGLRRGAQRRHRGRRREREPRARRKEGDEHRQCISSARSKAQGATSAAVSPRRWCARAAQMADVVRRHVMEPLWVWWAESHMLVMYAPIQWLVLVLIVLKCLLSALSAVKFVILAGVELGVPSLSHRLPLVCTILGVATDSLLIPTEMLVAMGWGLAFTAPPPTSHVALVCIATIALFIIAVLSATCERDGLSMALTVNTHARLINDSQCNAIAYTRAAFELACRIYNVLRMFFLSLWLSKTVIPADAAAMQRQRKLREKQLQRGQRKGRQGRGMAETGDSIDGEASGRSSPHHRPSSTSSGQCSGPSNVATTGTTTLLSTPITLRPPPRLDYPGVSLSAMEVYLRYRGMRVPFLMLLVWTILLLVFAFTFYEPEDYYMLIAFRELQTVYLLGFILLFFRTSSPFYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIG1</accession>
    <name>A0A088RIG1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_070710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009376">
        <property type="protein sequence ID" value="AIN95757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704079.1">
        <property type="nucleotide sequence ID" value="XM_010705777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIG1"/>
    <dbReference type="GeneID" id="22572406"/>
    <dbReference type="KEGG" id="lpan:LPMP_070710"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_070012500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_070710"/>
    <dbReference type="eggNOG" id="ENOG502S6QV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273174at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN95757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="515" mass="54268" checksum="14DF3D8B56AAD753" modified="2014-11-26" version="1">MFVRIRGKGACPENSQAAAMSIRGFRHTHSPPPLDSHYSVLLLSPSLTSTSTDAATKTDKPAGPPTTAAEPFRFALFPVGIQAATPAAAQAQYMSLSMAAISSAKANDGATTTAPLSPPVTLDSEANRMLWKETWNLYDILYDEVPLLPWIETTDDGVAAALVETVERELCKLALSDVASPMTTELHSLTSLADKTDGFKLASACTGSRQVVVCAHYYSSAPLSENLFHGVEGRRASNAAEPRLVASPVSMEGPVVVLDLADLPAAQAGGKAMVNIAWYTSFAAMQPDSALLRCRAVVVRLPYTSVPTYTQACRHCALSTSSADAAPTMADAFREAVDFIGEHVAAVYQGMVLALQTASPELAAKCTGAPPVVVIGSTPAALSSCLGFLLETPVASTTEKFNRANVVVIYGDHLGPMDTGSAGASDTHSAVEARSAHMVGQYKSIGGTCGFPVDFEMVLVPLKALLDGGEEPWDEYTLRERARLNFCPCCGDCSNNNNKGCSNKHDHGLGHCGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJ15</accession>
    <name>A0A088RJ15_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cyclin 1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_090610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S51 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN95977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704299.1">
        <property type="nucleotide sequence ID" value="XM_010705997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJ15"/>
    <dbReference type="GeneID" id="22572631"/>
    <dbReference type="KEGG" id="lpan:LPMP_090610"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090011300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_090610"/>
    <dbReference type="eggNOG" id="ENOG502RYZZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="61042at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03146">
        <property type="entry name" value="GAT1_Peptidase_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000093">
        <property type="entry name" value="Cyclin 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005320">
        <property type="entry name" value="Peptidase_S51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20842:SF0">
        <property type="entry name" value="ALPHA-ASPARTYL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20842">
        <property type="entry name" value="PROTEASE S51 ALPHA-ASPARTYL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03575">
        <property type="entry name" value="Peptidase_S51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN95977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="339" mass="36208" checksum="54E95EC6240C2CB3" modified="2014-11-26" version="1">MLTREVEMCMQHMNSIRACLAGSGYGAFREPATIDHLISLVATPKTGVVSVAYVGTATYDLAEGQAEQTSLLLQRGCTVRPIQVADPAVKSVNDDDRDFIKATADIVLVSGGNTLYAVRRWEETGLAQLLKDAAARQVVLAGGSAGAICWFTSGHSDSADPATYLQASLKMAMLKAGLVPQDQITKMEAELAELSTSWSYIRVHGLNILAGLLCPHFDVTQGNGVRREEDFTEMLKRHPTERGIGLDHWALLILKGDGAYESVALPGKSRVPTSGDASSTAAVPGVFILDVVDGAAQRRRMPTTGLLSDLLRVPTGPVVSDPFERFHAMENPTASSGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJ26</accession>
    <name>A0A088RJ26_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_081050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="AIN95913.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704235.1">
        <property type="nucleotide sequence ID" value="XM_010705933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJ26"/>
    <dbReference type="GeneID" id="22572567"/>
    <dbReference type="KEGG" id="lpan:LPMP_081050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000053400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_081050"/>
    <dbReference type="eggNOG" id="ENOG502SME1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267217at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN95913.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="337" mass="33876" checksum="D2DE569E4E2CD2F4" modified="2026-01-28" version="2">MSLPLTSLAGAIASPRVVAGIAPGSSSTDCYVIVWVEGKETPVYACTAPLPSSRLPAPSSSAASAGLAAVPAVNVVTLRRFFAALVLLSSPPPTAEARRGGRRVVLPCASSFTGEATTVLCATLPLGLVSAFGASPPYYYVAVLAPGTAAVVDDELLAWLAASVLAAVHPDTWAAAASAIGQGYGVALLSPPADAPDLCSQLGQYGAAEVGRAHADAAAVEDYGAREVLADSAAQSSLVEVLRGFESCCDSPVAVAISTLLRRCWAPFAISLATAAASLHISLAGYFALSLPSCPGASGEEAPRLEDAVSGSAASPLAPILYATVLCDRVLAKILIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJA3</accession>
    <name>A0A088RJA3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thymine dioxygenase JBP1</fullName>
            <ecNumber evidence="4">1.14.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">J-binding protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Thymidine hydroxylase JBP1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">JBP1</name>
        <name evidence="19" type="ORF">LPMP_091480</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Dioxygenase that catalyzes the first step of DNA base J (beta-d-glucosyl-HOMedU) biosynthesis by converting thymine to 5-hydroxymethyluracil (HOMedU). DNA base J is a hypermodified thymidine residue found in the genome of kinetoplastid parasites, which is localized primarily to repetitive DNA, namely the telomeres, and is implicated in the regulation of antigenic variation. Also specifically binds to base J-containing DNA (J-DNA). Involved in propagation and maintenance of DNA base J synthesis initiated by JBP2 by specifically binding already synthesized DNA base J and propagating J synthesis. Thymine dioxygenase activity and J-DNA-binding are independent functions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>thymine + 2-oxoglutarate + O2 = 5-hydroxymethyluracil + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:10316"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16964"/>
            <dbReference type="ChEBI" id="CHEBI:17821"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="EC" id="1.14.11.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="13">Monomer. Binds to DNA as a monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TET family. JBP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.6" evidence="4"/>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN96062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704384.1">
        <property type="nucleotide sequence ID" value="XM_010706082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJA3"/>
    <dbReference type="GeneID" id="22572718"/>
    <dbReference type="KEGG" id="lpan:LPMP_091480"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090020300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_091480"/>
    <dbReference type="eggNOG" id="ENOG502RTYX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275889at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050341">
        <property type="term" value="F:thymine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070580">
        <property type="term" value="P:base J metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1440:FF:000001">
        <property type="entry name" value="Thymine dioxygenase JBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1440">
        <property type="entry name" value="JBP1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024779">
        <property type="entry name" value="2OGFeDO_JBP1/TET_oxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041241">
        <property type="entry name" value="DB_JBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043111">
        <property type="entry name" value="DB_JBP1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18526">
        <property type="entry name" value="DB_JBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12851">
        <property type="entry name" value="Tet_JBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2OGFeDO JBP1/TET oxygenase" evidence="17">
        <location>
            <begin position="107"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Thymine dioxygenase JBP1 DNA-binding" evidence="18">
        <location>
            <begin position="396"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF18526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AIN96062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="813" mass="92447" checksum="C9DD199E56D77D8C" modified="2014-11-26" version="1">MESSTKRIKMDIFNFPTIKETRTPEEVAESYAEAVKLHPFYDNAHCVIDFYDSGTIKDGRGEIIGVVLRKALPKYATSMASVLLISAAVRTSLRSMIFGGESPLSGIAGYFDYRGSPVELKSRKTSFTYEHEEAWSAVFPVVDYVSEIYRHVAPERWKAQNNAIPDLVRIHGTPFSTLTINSRFRTASHTDVGDFDAGYSCIACIDGQFKGLALTFDDFRINVLMQPRDVMVFDSHHFHSNTEVEVSCSEEDWKRLTCVFYYRTALGEPSSYAEYRRRLEKSKQDPSFTPVVSNVMIKENGTNLNRPSPVHPVPPSPFWLPMLTHCLQHCASAAQSVHEAMTADGSQLAEIIFGEPLSISDGIPLRGDDEKLKANGDTGAKPLSRLGGFSETDLMVSTAAEKRKYLDSEFLAHCISVQLLDMWKQARARWLELVGKEWMHMLTLNPERKDFLWKNRSEMNSAFFDLCEVGKQVMLGLLDKEAALPKEEQAFWTLYAVHLSAACAEELHMPHDAMSLRKLNVKLKDFNFGGTRYFKDMPPEEQQRRMERKQRIEEARRHGMTGAHEKRANWLTNDSFDYQTEDCVVDYAKHKWVLPERHAKAVTKDVHTAWLPTREEVVRVLVVLPDLQIRVEGVDCKLEKPDTVEDSSEWVRLVSSPAVHRLLAAAQRNLQLPDDVMHGNIHIRFVFHSTLPTDMYDFVVLQHVLSRIPDDVLASSYITRAAALCSGCLFVEETDVQCRQYYTLKYSIRRNYDAVAPHFFQQLHQASYGTKMARVRTKGELEALIPMVCCARYKLQGSPLNTTIHVVSPTAPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJK0</accession>
    <name>A0A088RJK0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_040120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="AIN95339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703661.1">
        <property type="nucleotide sequence ID" value="XM_010705359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJK0"/>
    <dbReference type="GeneID" id="22571971"/>
    <dbReference type="KEGG" id="lpan:LPMP_040120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040006900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_040120"/>
    <dbReference type="eggNOG" id="ENOG502QR0N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="377549at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040346">
        <property type="entry name" value="GEX1/Brambleberry"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33538">
        <property type="entry name" value="PROTEIN GAMETE EXPRESSED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33538:SF2">
        <property type="entry name" value="PROTEIN GAMETE EXPRESSED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="596" mass="65709" checksum="4EB5552133928D33" modified="2014-11-26" version="1">MVGNYPSCTSHCPPCVRWQRWVLLVLAWAVTAVLLGNCTLAWPQFLYMQRRVELPAAPHADTDGTHASIPPRLFPGTEERGEQARMLWEEVEAKGRLSPCWKRSLQLLQAKCAEVRSEDTMRSRLGLFMATCDANSDGRTHPSFHCASTATLPSDLSTRAVRQCVQGLSDSAYAAFLQYRLHADVLCAYLEEELYQQRTEAAVAAMHLQMQRSSHMLTALQHSGAEVVALMKDSQTLQQESREAASSLRHQLGLLHNGQAAALQALQQAAGDILRTSSHTDAALGELHTRVQEAAAEALASVQALSQESLKRFAEVEAQTRGVVQLMQQVDSLHHLLTRQRLPRHRVVWVLGCILGVLVLTCLPQTAAARLPATLFTIIGCVGVPLLRWWTGQSRWLFLHETAWESLCLSLAVGLVGHCAYRYTPPNIWRHRSLAREEAIRVWDELHVLQQAKKHQLDGTLLQAYVPQIPILGLQPHPRMLRNEAPAPSLNISHAQSPLSITVSPRGGEVEGTPTTANDSHSTAPSEGSVNAPDEVSSAAGTPNRRRGRPATTGDDAAHRHTKSQRTDAADRHRCVAARTKRSTARSTSETMLRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJW8</accession>
    <name>A0A088RJW8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Starter acyltransferase (SAT) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_111030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696950.1">
        <property type="nucleotide sequence ID" value="XM_010698648.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22572968"/>
    <dbReference type="KEGG" id="lpan:LPMP_111030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_110014100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_111030"/>
    <dbReference type="eggNOG" id="ENOG502RYFV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5417908at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Starter acyltransferase (SAT)" evidence="2">
        <location>
            <begin position="271"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="930"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1009"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="935"/>
            <end position="950"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1356" mass="145005" checksum="FA871EB2CDA68FAC" modified="2014-11-26" version="1">MALCNPRRAFRAHHYHPVTTAPWSKHGAVLAVNLQHQHQRPPVVWSKSASDAAAEWGNGDERSQDRQRQTRHKEQQVYAGEPARQRDGATVVSSLRRFLSAIPIPSPPNQQQQQQQQRGGVGNSDCASLFQQLQSTFLPSSSPPPAAATLPSPKPSALPTFALFGALERLSRFSEMVQLCHEHADVLDDFLARLTLQLHRSSCAPALLLSGASAAPSQSSLPPPPSLTTSAAHDDGEFLRWHRIVMFLLRQPSELAKVGVEFFSDAVNSWPLHMLYLTCCFYVTAREHGFDALATTLSKGGIFCSGKGLFAALAVSMAQNEEDLIRSTACMYRAAFYTGVLMRKRHQYFETETRLTVNGGFTLLVVNIPIITLRRLVARVNEGYDVFASMRDVYKESEAERGNTWFNVNSHNTAVSADTAPSLLGRRGGRSYSPTSSSGYASASSPFAPSMPHYPHSVIEVSRVISSRSAVLCGHPLDMLRLDTILARFADFNDVKIHREYLPSGGPENSCFFNKHMAHDLTGLWKARGVSFSLASVQLPLYSPVNGDLWTESLRVPVDPPAPPDASVTTVASACDSNAIFCAAAPPPTEGYRDEWWMFNVAEAATCANQDLTYSLRHMRDGSVLLDFSTHAIRIGRLIAWTSKSITVLAAPENRQESSAMPPPRRSPKEKVIRNTMEKLAIINSVLREVSDRIDQPPDALANPSVELFTTFTELGLLGVLKGPRERPGVSHFGEPTHAASVILNERQRSHHSYYNTGACDAPSGAAVTSGAPSTSRLGAASSSGTLNGVLSSNGPAAGRRMRPNVGALVSLNNVSPSNTNTGILTTASNLNNPGAIGKRHTNSLSLSSAGGVGGSSGLSAPSFHTGSAAGGISSGVLAAFRSRHASTVDGNPVTGADPGPHVEVGGTAVVSKNSFLECHSTSPLLSAYALTSNSPGQSPTPQLTSSSSPEAVGEARLLPSALMYRGMRRGSSHVTGAAHLLLDRRMTTMTSPYRIPSSVSANNTGATAAGLEARTKSPSATYTAERDGSPVSHVRSHSCEADAHEGMAATIPAGAVVGGLGGELWHTVSLISQSDASNRQRTPTATTISIGAVASLQPKTKETSVVRGVSLSPLPASFLSVPQEAHSRPSSFSPGRGCNSAVVTSNSLHEAPVSAFFFPSDGLAQQVSELELTSEHRILSVPSGRRSSHLLASGTASSRRERGIQYEAPVEGDRLNNGRDGVIAFDDDSAAVRRVPDDTLTPGSECFPLSMYENDLVIHRSNDYAGIVNVYQVSALITYYEMQFNCVLCDGAVLFAGLLKRASGIAFPSYTLLLCPTVFSLLELWDGYEFEEVWRRSLGAPVCSRVTSPISAGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKA2</accession>
    <name>A0A088RKA2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_110340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696883.1">
        <property type="nucleotide sequence ID" value="XM_010698581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKA2"/>
    <dbReference type="GeneID" id="22572899"/>
    <dbReference type="KEGG" id="lpan:LPMP_110340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_110005800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_110340"/>
    <dbReference type="eggNOG" id="ENOG502SIX6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266466at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="401"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="488" mass="51227" checksum="93F1E600042A8C1F" modified="2014-11-26" version="1">MVYKHKHNKKARSIAVRKLQKAAEVAAAAAAVAATLVPVGGDGESATAGYCDAGLSSTLSTGGMATSCAPVTINCKYGTAAAAESLTDANMGAADAEEMFQEKQSKTRQQQQQPGTSGDRSCSDMSGLLYSAPPTPADWARLSVASGAARLPSVLAATHLPCIPGITPCSPRSGADGGGEGQYVAYLLSEQLSNGTTMPMTMWGVYSLRDGDCLQVVHWHHSPVAQESPLTNVGLHPPPTSSNAQQTRELIMRVDAAGLCFMLAPSSLVSMDGSGAAGCMTLNSVCSDPDTADDAAAESADVYWLIPSVMKESFFALLQAREWLRTAPLRHPVSEACTRSLECQGWFVQPHPTRWASAASSVEATVTVAREQHKSSSPATATLPLPKRKTKKARRKRRQPSPRAQPRQCKESTASTTSATNGTAPTSPFQYLIPYVAAVQQPQKGLRGVPESHLPSAAVPAATATPVVLLIGNRIASYPAGEVCGPRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKB2</accession>
    <name>A0A088RKB2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L19, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_060400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703921.1">
        <property type="nucleotide sequence ID" value="XM_010705619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKB2"/>
    <dbReference type="GeneID" id="22572246"/>
    <dbReference type="KEGG" id="lpan:LPMP_060400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060009700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_060400"/>
    <dbReference type="eggNOG" id="KOG1696">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5407653at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01417">
        <property type="entry name" value="Ribosomal_L19e_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.240:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1650.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01475">
        <property type="entry name" value="Ribosomal_eL19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035970">
        <property type="entry name" value="60S_ribosomal_eL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039547">
        <property type="entry name" value="Ribosomal_eL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000196">
        <property type="entry name" value="Ribosomal_eL19_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015972">
        <property type="entry name" value="Ribosomal_eL19_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033935">
        <property type="entry name" value="Ribosomal_eL19_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057259">
        <property type="entry name" value="Ribosomal_L19e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057260">
        <property type="entry name" value="Ribosomal_L19e_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006343">
        <property type="entry name" value="PRK08570.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01280">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25476">
        <property type="entry name" value="Ribosomal_L19e_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01416">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48140">
        <property type="entry name" value="Ribosomal protein L19 (L19e)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL19" evidence="5">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="159"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="163"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN95599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="263" mass="29765" checksum="F4A033B979938F0A" modified="2014-11-26" version="1">MVSLKLQARLASSILGCGRARVWLDPNEAMEIQNANSRKSVRKLIKDGFIIRKPVKVHSRARWRKMKEAKDMGRHSGVGRREGSREARMPSKELWMRRLRILRRLLRKYRADKKIDRHVYRDLYVRAKGNVFRNKRNLMEHIHKIKNEKKKERQLAEQLAAKHQRDEQHRNKARKQELKKREKERERARRDDAAAAAQKKKADVAKKSAAPATKAAAVSPAKAAAVSVSRAAAAVAPAAKVAVPAKAAAPAAKAAVPAKKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKJ9</accession>
    <name>A0A088RKJ9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Membrane-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_131190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697200.1">
        <property type="nucleotide sequence ID" value="XM_010698898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKJ9"/>
    <dbReference type="GeneID" id="22573229"/>
    <dbReference type="KEGG" id="lpan:LPMP_131190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130016700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_131190"/>
    <dbReference type="eggNOG" id="ENOG502SH6X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273527at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031797">
        <property type="entry name" value="DUF5075"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35613">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35613:SF2">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16825">
        <property type="entry name" value="DUF5075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001838984" description="Membrane-associated protein" evidence="3">
        <location>
            <begin position="28"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN96547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="468" mass="51242" checksum="EAEA9EABEDD5F111" modified="2014-11-26" version="1">MKLPASLPLAVLLVLLTLSGLAEVAQAQGLLGLLALQMKGYTSYSSASLLSSGIAVTYSSTETTCFDAGGVPASDANTRLSNTVAYWMSINGGGSTSTIYTGSSAAPSLPNTACAERVEGATTPNSANCYYRWRYGFYDMYSYKDEPGTAYWANLYQQSSGGSQVLNQFEQFIWEPKVDASGKRYPRGYFGGVASFDPVMRGLYRMDAPLVPKNNDPNPTSSFMIVCEHQLYPERPPFTTRMPQPVFVNGFKTLMWSQSHWWVIFLIVAIIILAFLFFIVIYCCFTSMKPKEEPPLFVMVIRERVGKGYVVTDRASQATNQQYAVPGGMPLPPQMLSPAQEEQRRQMRYGRGFNPLQPHGSEDMAVGAAGIYQNGGRTQYAHGNVPTNSDGNLIGCNAVDISEEALSYQGSSQNVQEADGAGNASQEPSLVTSKRRSMRRSRNRNISQAFDDVEVPQAGEIDEANVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKK5</accession>
    <name>A0A088RKK5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-directed RNA polymerase III subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_131240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697205.1">
        <property type="nucleotide sequence ID" value="XM_010698903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKK5"/>
    <dbReference type="GeneID" id="22573234"/>
    <dbReference type="KEGG" id="lpan:LPMP_131240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130017200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_131240"/>
    <dbReference type="eggNOG" id="ENOG502RXDE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="340681at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006886">
        <property type="entry name" value="RNA_pol_III_Rpc5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES III 80 KDA POLYPEPTIDE RNA POLYMERASE III SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04801">
        <property type="entry name" value="RPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="697" mass="77135" checksum="9CDABDBDFB5172BF" modified="2014-11-26" version="1">MSFGTRPASIEDDEVLASFNVYASSALVHQAHIFQYPLRRRQRPYEATEVKLFITGGLLADENEASRAHGKGSPVLQSGSRLTMKCSLDTFGSHSFRRLQESAPNMLSQMELQRHHTFHYTLQSQPFLPQSNYVVGYITPEGIHLTPVSTIQQFTPALSIPESSTGAVRVMEAFCSQANSSAMSGYAAADRIQRELRRQRSRVLNEEAETAQEIQFFRDDSVESAAMRSRLRSSTLEKIIDSPSMASEPAEVANSLFPPEILQSGGISGGDEAHPSMIIHRFANRKSVAEQTSQVLQRCHILTLRMLQSIVVPYTSNEVVRTMAAVPEAQLVEALKSCAVWLHGVWVSRYCDQFRGCVAALREVILARFYQSEDGSVARSDLNALITTSEARRSIKEILATVAVLNTEEPDPSKRRWRLKCVPADRAAREANLRDFKTTFAAEEASQHEAWRRRCTQVMAHIPYINAGRPVPQLCLRPRGTPPTTSMAAGATFPYGGASTLQSFASQTSSMASGHPGSSVNTSASPFSSPVSGMELSFKDADIAPIRQYIRELFAEHGVINKQRVKDLVIKTQEARYPHATKAMLSTALQQCLDKFTDATWILKSAGEPLVDYYRPAILYVVLELRQFEMAALMKRLEEVVWARGLTSPPESAALRGRAGSVSDPLEAVVQRVVAEVAEFKAGGRLWHIKGGNLMNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKN6</accession>
    <name>A0A088RKN6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_130740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697156.1">
        <property type="nucleotide sequence ID" value="XM_010698854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKN6"/>
    <dbReference type="GeneID" id="22573184"/>
    <dbReference type="KEGG" id="lpan:LPMP_130740"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130011700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_130740"/>
    <dbReference type="eggNOG" id="ENOG502SA9Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267867at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="564"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="793" mass="83769" checksum="12229A144FA465D4" modified="2014-11-26" version="1">MEEAHALEEQEPNGDGSMNTEEDGARSTVTPQVPAEAPELPHAIARLETVEDMKEQEDAATMQDSASPAEALDGVEEEHAADPDVDDNATVPEEGEQDGSASADNAVAEADAAVTRSPIVAEHDADGAVVSASEDGVQGNTSVDNASDVAQVGGVGNNKSESEEVRSDLGVEEEPAAAVSAAADAPPQDTNAGAVADAPPAAKPPQALKGGTPLPEATAELPTPSPLPPPPRDLPRWQSRQQAPQPQLQQQQRPAAVLHHGATPSASSMSPYATITGVDGVYDLPEAERISVAAASLTPNTVLAVFRRGGENSHVNRMEIGSYSRYLLSTDHMSPLVFEATFHGHQPTVGVVPRSTLKDFGSGNVTNDYADDGIAARAASASSAHRTYQSPRSTFSAARQTMSDTFADIAASSTTLRRENDMLDDANLSALSVLRRQRRRDPRHGKSVDEQRNYVYYNHRSKGFFVPHDPAPDTVMLQYNHLYSFGDGTRFAPVGSPLNGKNGAAATTAHRRNPHAAPPRTFAETRGRAFPFTASQRQYASYNGTVYGGTAQPRSRITKLVRAMSSSSSQANQRQRAETQKGSSSLRTAKAVDLERLYCTQLPRPRTIEEVMADQPQRYLCGAEGVRGALVQDIERDIEDGKLQWEEVPPAMQKAMTSATTAVTAVAQRRQLGSSVSLPASSTLSASGRRPRCAESLAMAPNALKSVMGQMRATPATTAASGGAAAKIMTTAPPSPAAEAARVTSSACMTGSAASTSRRMPIGSMAAVAALPAISRLNYTPRPTQRSNPSAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKS9</accession>
    <name>A0A088RKS9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">40S ribosomal protein S9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_070730</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009376">
        <property type="protein sequence ID" value="AIN95759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704081.1">
        <property type="nucleotide sequence ID" value="XM_010705779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKS9"/>
    <dbReference type="GeneID" id="22572408"/>
    <dbReference type="KEGG" id="lpan:LPMP_070730"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350018400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_070730"/>
    <dbReference type="eggNOG" id="KOG3301">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="259794at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000023">
        <property type="entry name" value="40S ribosomal protein S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_uS4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005710">
        <property type="entry name" value="Ribosomal_uS4_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003139">
        <property type="entry name" value="PRK04051.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01018">
        <property type="entry name" value="uS4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF5">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9 12" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 8" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="11">
        <location>
            <begin position="5"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="10">
        <location>
            <begin position="106"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN95759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="190" mass="22122" checksum="28EFAEFA4CF43635" modified="2014-11-26" version="1">MRNYNNFNRVWKAPRRPFEKERLDREMKLCGQYGLRCKREIWRVNMTLSKMRRTARLLLTLPENHPRRLLEGSAIMRRCHEYGFLDEEKDKLDYVLSLTVPDILERRLQTIVFKAGLAKSVHHARVLIQQRHIAVAKQIVTIPSFIVRVSSERHIAFADASPFGNGRPGRVKRVRVKAAKRHAAGGGDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKX4</accession>
    <name>A0A088RKX4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DNA repair protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_080150</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="AIN95824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704146.1">
        <property type="nucleotide sequence ID" value="XM_010705844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKX4"/>
    <dbReference type="GeneID" id="22572477"/>
    <dbReference type="KEGG" id="lpan:LPMP_080150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_080006300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_080150"/>
    <dbReference type="eggNOG" id="KOG0442">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="361020at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20078">
        <property type="entry name" value="XPF_nuclease_XPF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000002">
        <property type="entry name" value="DNA repair endonuclease XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000154">
        <property type="entry name" value="Putative DNA repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047520">
        <property type="entry name" value="XPF_nuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150:SF0">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="11">
        <location>
            <begin position="1032"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="552"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="703"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="564"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="703"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN95824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1261" mass="136554" checksum="52123937191539D9" modified="2014-11-26" version="1">MSVEKIVTPTLGGTFRTCSEFIGTVSAREMPDNPSVQLCILSIGFNLESVVAQLLHQRMALNRPHRRVYCVVLPERLLPGAMTRFANAIRRHLALREAGEMISRHADASAAATASHHASPMPVVAIEEGTTTKERCAVFQRGAVVVLTSHFLCADLLHRRLAVELVGMTVLALPHSLLGRGQPQDALAPQAAFCSELLLRSGSTAAGGQRPPSIVLISDAPVLMQSLVQRHHMGEERFVLQMHVGDIQLFPRFRLDFVRHFEELSRASRRPITVDRIVAPVAASVQALDGLLAKIVLETLQELQRLEQQLHTRSSASGGDPTTDSSAGLDSQANARPFASPCVGAAAEADEDTGVLRFLPRARLTTNAVKGRIDYSGHPRSGTGAASYIRRGWRARTEHDNKGILFGGISEAAALSVDFSDLDNDLRAVVRRHESHWPYRLLVESLIDVRRLRRATRGTAYTFLRELEAVLEPRLPRCSVFGTGATPPSALWTLSSHFHDVVTVATHRIGTVVYVPSTASAALTAPMEGAAMLPANSADDVVVVVSSSSDSEERGETLLDAAPTSATSAPRGQVPTSAGGTLVPRLIPNVEEKDTDVEVVVRLVMSWCRTMLRRAERKSDAATDAPASHPTLLILVFGTKDVVRYTERLTHSLEAYQQLQLRHFMRVYQAKYDVELTELVEAQPADAAAPQLPIALLTSVDDASSDGEEDLTTDEDSSADGRRGRRAAADSAASLRHRLSSQGGHATAATPRDTTPLYADEGNSSQSVMMDIGVGAFHQALLSQLPPLLASSGERADIKYDSEPQSAARASLAAPLLVLERVREGVVTLCPDHRGATRDCGVTTSATLEGMPRVLVLDASSLSATELTMLLDGSHAALQLAVPSTAAPQMSTADTNGVKGTDSVSTYLRVDRVILARQELMLLRQLEMAQDELPAERLATIKVQLVTTSLAELDFKKAVQAERQAFESLAHAKATLTGSLLVDQTSLRQAEEALESGMRPVRRRRVRKDTAVGRLAGDLLHRPDFPPSAVPCIVFDERELRSSLPYHLYRRGMQLIPLTLVTADYVLSPEYAVERKSVQDYAQSVMSGRIQRQLAALSRRYAHPLCLIEFHRGVPFRLMQNGIYAKTAELMAAYPRVCFVWARSPAHAAGMLVFLKKSVAASNADPADPSLTGISIGLGSAADVGEVTATAAERETAHYAARVLSKFPGITHQNAPSVMRLCGSLIGLATISQASLVSVMGDRDAARLYNFLHSPFHERVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLA6</accession>
    <name>A0A088RLA6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleoside triphosphate hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_141000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697331.1">
        <property type="nucleotide sequence ID" value="XM_010699029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLA6"/>
    <dbReference type="GeneID" id="22573367"/>
    <dbReference type="KEGG" id="lpan:LPMP_141000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140015400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_141000"/>
    <dbReference type="eggNOG" id="ENOG502QVW3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN96678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="505" mass="57169" checksum="92B3FE990F931F10" modified="2014-11-26" version="1">MIGLKSMSGVRDVVRGGSWPARLLNTFTSRAARESFEFDAVVTEACATANVAVPSEADLPHAHWWKKLCRACQDKTGTTKHGSQLLRSRLTNALAQRLAVEEVYRLNGDEIAKEDAVDDPIVVMGLPRSNGHMAAHVLTRSGLFLTPRQCDTLSPSSLLDIERRDAFHKKFRGFSYLHPDFLCVRVPQADQVDDDLTLHLMTPQSYAWGLLHGLDEYLLECLEEDQLPVYTEVRRVMELLQWYWKCGHFSEPVTREFDPIDNMMERQTYGTKNVLLHPHWLLYSPFAILSSDAVNIVFPKMRAIWVHRALSQCLPSLCSALCLHNGLYTGKPPSDSQLASMGEKVLGIFGSGTAHAIEYYGKFDQRRMAHWSNRDVKRHATRVATKTLDYFGIELDRYRRMQMISGQTEYVSVSRPLHDAQMPYFCLHDGVIGDVFQDYIYQFEEFAFEKKFGITLKEHTPLAAPADAMAMRGIAHGSSEPRSAPALGLGQPMVGHFQQESRGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLB8</accession>
    <name>A0A088RLB8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclic nucleotide-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_151100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697485.1">
        <property type="nucleotide sequence ID" value="XM_010699183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLB8"/>
    <dbReference type="GeneID" id="22573530"/>
    <dbReference type="KEGG" id="lpan:LPMP_151100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150016300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_151100"/>
    <dbReference type="eggNOG" id="ENOG502RDAV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2118811at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054204">
        <property type="entry name" value="DUF6909"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21850">
        <property type="entry name" value="DUF6909"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="152"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="789"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="820"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="793"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="820"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1060" mass="119430" checksum="AC762F715CF76136" modified="2014-11-26" version="1">MDPCGECIPTQQHALVALKQAVNHVHTRLHQGSVSMLTESGSSEEERTAYRIAQVARAVMQAAGMIDQEDVDGTLNDSDAHDTPSKATATRRSCRQTDWRDDDDFIASPSIFLHLDAAQPVRSNRVMEYIVAKGRAAHTSEELTWLYRHSQLTSLLGPEDLQHLVPLSLHREYTHGELILDCGAPVRHLYVVVWGNVEVFRVDSINNERKAMEEAFRVASHQSVSMKLSRTSDRRGSLSPYGLRLTDVQGTNTNSEVSSDAVYTHVADLYPGQVFGIENCVFNAASHYVFRAGSAMSKTAISLLPYEELQSVLARNPRFAQGVGVRITDSMDVFGSIREFCRYVFSPTSAQNEYLPLWSILESYTRVHNVIHTKLFSHQVDTGAWGYALNRLPENLTSTFCFDLVHALPPFIARRMQVEARAADTRKGADSLAMKGGSMRSSITYIRTKERRRCTWHLGMEGKTLVLLRDGFTDLLDFLTMLCVHIIESNKLRGRVQGMVHPPAIDILDEYLRQREQEELAGKYLTTGGVTRDAEMQRVHAILKRMPLTEEEQAGLLRNWGHNTLLRIYEVMMHREEYNVRVDPSLSMKFQMNPFHEWALNLRSCVLEKLGLDRFSALPDNLYIDVISSNTHCIKNLLCGFNRKYRKEILDYACRTESKRLGRPEEWHNVDDMLYVALTGFLQNERPDLKEEHSRSLEENGITVLQDTAMTGLQVEVIPVHRLNFNAIDETIREAMHKYYEEVTKNDSEKREGKTGGSTVPTWAQVCKPIYRRSQDGSKTHVLGCIMTDSRGDTSPNDSDVEPGSTNLETASTTKKPTFTEFSEPANMNSNRGSPTVTPAAHHVRDGRLQRHFLINMDFAFGAQAEGICRVIFSAFGKRIRSVSVVGKAGGLTGKRGDIQLASHVLLSKSSLILEDNQDELRNCRNQDLTAQRLQELAGPRVKVHHGKVLTVTGTMLQNVQLLRYYQQVWRCVGTEMEGSYFARVIEDFYRQGIAHPGLTSRFAYYTSDLPLAQNDAEIEARQTHRLPASAATLSAPMSPQEGVPPLYAIARGILEKVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RM37</accession>
    <name>A0A088RM37_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_110630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696912.1">
        <property type="nucleotide sequence ID" value="XM_010698610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RM37"/>
    <dbReference type="GeneID" id="22572928"/>
    <dbReference type="KEGG" id="lpan:LPMP_110630"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_110010100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_110630"/>
    <dbReference type="eggNOG" id="ENOG502RYIC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266798at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="573"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="663"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="815"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="815"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="834"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1121" mass="117977" checksum="37ABCC6417109A56" modified="2014-11-26" version="1">MGDMLNSSDVDATVLPWTPFISSDVLGETMEELLLPSQGDAKEQHHRKRQQQQQQQAPSKAFISLPTPVQSSPIPFITSMDVSAFFSGCAGGGTPQPFSLLLQQRPPPCISQGLSNQFNTVSQYTASSTVHALDTNNAPATDFPLVDARSSFAMPLNASSANQADGENLSRVVSSTSNHGRACGDGRSRASRQTHVHGGTSFFSTSLSSRPSSPLSPSPPAAEEHISGYTSLYLPTAAPSFACDDDYTHAMNGQVAFVEQLCEGTSDHDGDGNGEPEVLGMSCDMSGSPPQQCLQQSASLEVRSGSFGGLLAALGSQAVLGTPVVVRPFTEYEVAASLSEPARPAPPPLSTFEPLSTAMTYPNEYCVCVAANTAGAVTARDTPIGSNISDASMHAQSQASSGNLQTPLIPSQGMVLHPQQQQQPIQRVHQQQQQRLGFTPSPLPTQMWTSNARVASAEDLAALSSSQHQYQQQLQASVHSQSSSLQYSVGATSGAATVIGQAFSSSGTYTTSPAQSFSAANGYYTRSSTPPSGGPAQMIMLLPSFSENSFTGNSTQAQQQQQQQHLYAMQVPAQTPPTSEGASAPLCPSTHGSGAVQSPSMQPLTSTTMSAGGGVGGVTLFYVAAPAAFAGFPHTAVSSQVNASSPSGVSGYSCAVSMAQTSAPERPAPSSHYVTLPPSSPANNSQSQLLPLQEYTGYLASQQPNVGMPAVSEQAALASLYARTSSPVGKTAAANLPHVTSIEAASLGSKAAGPTCPGIRSVVSSTNTDTLRKQINVHGAMLNVLHYYPYHENSPPAPTAHIVTGPGSASNSTVLQSLGGSSWSAQSMSSNLERNLDGSRRSLDSGKSQNTAEVFSCAFRGDTSTLENAPVLPIFIQMFPCELRDRVGLLNRVIEATCGRNAGLAQSFETRSETSFIAHVRTNNVWELIYKLRCRVLMDRFGFWYAADIDQYVRMKEYCEGVRRLPQQTRHFQTDGLPCMPLVVELSRSVDRGLVAENNAPRCFDELVPIAAVDRHRVRLQGPSSVHSGHSSASMNGMLMAGSGASTAGGTVFLTNVGGDGRPLHGGSPVLLTNEGHMMMMPPHMMSGLANGSYRGGGSTSGSCGQVIYADPHFFPPPFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMB1</accession>
    <name>A0A088RMB1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_120210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009381">
        <property type="protein sequence ID" value="AIN96349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697002.1">
        <property type="nucleotide sequence ID" value="XM_010698700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMB1"/>
    <dbReference type="GeneID" id="22573027"/>
    <dbReference type="KEGG" id="lpan:LPMP_120210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_120006900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_120210"/>
    <dbReference type="eggNOG" id="ENOG502SIFM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266719at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="723"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="838"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="984"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="416"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="623"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="668"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="756"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="773"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="785"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="838"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="855"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="984"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1025"/>
            <end position="1041"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1097" mass="114726" checksum="417B61DAD7853888" modified="2014-11-26" version="1">MPLAQSSFPAPPDSDGGSKEGKPEKASMTPERRTQERMCSSFTSASALTGTPGASVTTSGRGNKDCEAERIDAEHHAVSDTQDHEPLLHQMSSSTDITDSTSSLLRPQLFTLLHGAGTARTAAGDGASSSVVNPILAPISSSTPTTAVSKVSAGPLGTPSSCQQIEPQLSCDTSTAAALNSSSATTPLTTAGVSACVLFFSSPRGRNLSNVSHRLYQTFFLWADAAASLAASSSTRTTPTEKSRVLPPLSSSSTRAGHEDASDAGAAAAVGHVEAEGRSESTGVTAPLLTWVHPAIEKRRPAGTDLPDDGTAAATAATPSVTRQRQAAGVGCSDVVPPRSVASSLTSCSVTAVTQSGPQAKESKSHTFTKATATQAPLLLECEGAGSSSAPVTGCSPTESGLPPEVSSQHTDESESSSSDLRFSSTASPSMHLARYTITDAEQRSRPSERSGHAGNPHDHGDCSRDIKPGGSRDDGTKERRPNHDHNSDRHGAARSRDGDVAYITMSSLITQVAVPPTVHEVLRNANATKEELWMALRTACQQCELLQRRLARAEGALGKGEEGEATEDEEGAADEEGALTNTTAHRRRCRHVDTPSKKPLRTHTVEEKKKATNRGNTVKVVSAAQSRTSSTQADSAQMPSSTAPPTPTQTSRQSSSGHQARKRFAKPVPAAASTPPTSASVLFSGRTSTTAVNLHGRGYCGNNDASSALRNRVSEAIRRFEAKRKAPPHSPRVRQSPEMHTRPEICGLGRPMNSRDVTNGSQLSRASTACKTVRDPQHSPHMESGSSRSSSDTGAASWCVSRSGSANSLGEAPVSSGSGILMMPEQPVIAGLEAQDHVAQRGCKSTERVQPSPKRQKSRHRHREAPLLSVNLVSATQDESVCSNGPAAATESLTALSGAAGSIPATWPSYGMQAFCKGSRGAESRNGGPRAACSPMQLSTARRQSGWAQPTSANGASAAVIASLVTPLSGALPALHPSIVSRRSPTLRPTLQSGESISSESARLRQHPSPKATPYRAAAARVSYHTTQKQQRTSPQSRSPKTAALPAASATLEMLKQLQQEDAPVPPVTSDDQKAALRQWRREAAVMKVKGSAPTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMG5</accession>
    <name>A0A088RMG5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_170020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697693.1">
        <property type="nucleotide sequence ID" value="XM_010699391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMG5"/>
    <dbReference type="GeneID" id="22573745"/>
    <dbReference type="KEGG" id="lpan:LPMP_170020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170005500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_170020"/>
    <dbReference type="eggNOG" id="ENOG502RMQY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10266771at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021910">
        <property type="entry name" value="NGX6/PGAP6/MYMK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36561:SF2">
        <property type="entry name" value="HAEMOLYSIN-III RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36561">
        <property type="entry name" value="HAEMOLYSIN-III RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12036">
        <property type="entry name" value="DUF3522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN97040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="221" mass="25741" checksum="5DD03C685D3D8D53" modified="2014-11-26" version="1">MRHGESPAILFIMTVLSHLTMLPTPYFFYRRNYIFEFCCAVFGLLASFMYHTTESFGTAIFLTEIEWHRLDNVGVISMMGIWYVYLCCFQNPFVDMSCKCFCVFFTLVVQQKNPWDIRLTVSPILLFSLFPIVKHCLVEQRPPSISRKHLAYGLLCFCIGIIFFILGLNEHADRYRMYHSAWHFFAGLSAFFFWVMVKAPGCTGSYGHHRHDFVVRGGAIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RN29</accession>
    <name>A0A088RN29_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Band 7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_191150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698110.1">
        <property type="nucleotide sequence ID" value="XM_010699808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RN29"/>
    <dbReference type="GeneID" id="22574169"/>
    <dbReference type="KEGG" id="lpan:LPMP_191150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190018800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_191150"/>
    <dbReference type="eggNOG" id="KOG2620">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="434619at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="CDD" id="cd03407">
        <property type="entry name" value="SPFH_like_u4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050710">
        <property type="entry name" value="Band7/mec-2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327:SF31">
        <property type="entry name" value="HYPERSENSITIVE-INDUCED RESPONSE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="1">
        <location>
            <begin position="4"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="283" mass="30896" checksum="D472120B8E080C17" modified="2014-11-26" version="1">MSSCGCGCVSTSEVGIIENCGKFDRIVDPGCFCVIPCVESVRGVVSLKVAISTVRVETKTRDNAVVNIETRLHYKVIPEYAEDAFYRFSNPSEQIASFAASIVRGEVPKYTLDELFLMSDEIKKVVGSELTEKLRSFGFSLESTLLTRIEPSLSVKMAISQTQINAYRRTAAEHESELNKILAVKAAEADYEEKRLSGVGLAQERKAIMNGLKSSIETFVNTVPSMCAKDVMNLLLLNQYFDAMKEVGSGKSNQLILMPNTCGASPNFMADLVAAQAGATRMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RN48</accession>
    <name>A0A088RN48_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_191410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 3">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698135.1">
        <property type="nucleotide sequence ID" value="XM_010699833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RN48"/>
    <dbReference type="GeneID" id="22574195"/>
    <dbReference type="KEGG" id="lpan:LPMP_191410"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190021400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_191410"/>
    <dbReference type="eggNOG" id="KOG0543">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001577">
        <property type="entry name" value="Peptidylprolyl isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000053">
        <property type="entry name" value="Peptidylprolyl isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050754">
        <property type="entry name" value="FKBP4/5/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0697">Rotamase</keyword>
    <keyword evidence="2 4" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="6">
        <location>
            <begin position="56"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="369"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN97482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="432" mass="47742" checksum="58D7F9900926DD88" modified="2014-11-26" version="1">MSDQLTDSAASTASDDSQPQMEVLYPLNEEVEVPGTDGGLYKTVLVEGAGSQPVKGAKVTVHYVGTLLDGTKFDSSRDRGDYFEFTLGRGQVIKGWDKGVATMRIGEKALLKCSPEYAYGAAGSPPSIPANATLLFEVELFHWTREVDISAAKDKSLMMSVLKDGIDYENPDFESSVTMDLYIYVGDFDPANKEKHTPVKVMSGWNVVVGVTSLPPQLEAFLYKMRKQEAAACRVRSDLICDAAPEFAIPSSADRGHGDVTYVVEISELSRVKTYDFTGEAKIAEGEKRKNSGNDAFKAGKLDLAERFYRRAMEFIGEDYGFDDAVKPECHRVRISVMGNLAQVLLMRNKHTDSAEFSRKVLGLDANNTKALFRLAKAQDGLQEWEEAIKCVDSILTIEPGNADAVSLKAHLKQEQRAFDQKQKSMFKKMFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RN77</accession>
    <name>A0A088RN77_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_190560</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698051.1">
        <property type="nucleotide sequence ID" value="XM_010699749.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22574110"/>
    <dbReference type="KEGG" id="lpan:LPMP_190560"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190014400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_190560"/>
    <dbReference type="eggNOG" id="KOG0585">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053235">
        <property type="entry name" value="Ser_Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361">
        <property type="entry name" value="MITOGEN-ACTIVATED KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361:SF433">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="740"/>
            <end position="1642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="314"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1016"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1218"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1389"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1649"/>
            <end position="1679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="314"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1016"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1038"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1391"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1653"/>
            <end position="1667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1669"/>
            <end position="1679"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="769"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN97398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1679" mass="177022" checksum="8D7ED20B1FFB319C" modified="2014-11-26" version="1">MMLPPSAPSWDPGPPDPALYSTTSSRDDTPEYGDTPTSPSCLHIVRTTPPGLSAEDGTASPTPASMEMSKRETHHSQCSTAQPLKPLTAELSLASVAEVPRCTLAGVTMQSSGDLPHSSMDGGGVSSALIRATPTAPLAQVDGPLRLPLFTNPSSVRLRLDVMLQVSSGNAISDQARTSASSTSSNRREVSRTWQQSPLTFVSQLPSDSCIRASSLAGFCVQHVKAHGRNEVPFPAPPSVHPALSTTNSAGVVSVLSDTHFDRSVDDACGAVESNFIGAAAASCTVVHATPSAFGAPPRPSTALSSGLAGVGGAPSLNSSNPSTSVSALKDRHSSGTGMDWVPSKSSSLQPFRASLLDSDDVGAEDFGSEVSGTEVTSVRVEVSHRRCDSAVTGGRCSRLASGRSVSTPVSGALGGFAPDVSGTSAGGTTASVAAVRPAGTGSGGGAEVQATGCPFSWRMFSSLTSQRGSGDGGAPASSLGIFQSGLFLSMDESDALPASVMDVPMTPQSFSTMLLARESGEGVPYTFRTSSAASVATTNGARFSPFPPPVPEGSDTLLGLSSQQATILSGAAEEVWCRDGVTVKRTEEWCVDGGDRDSHGACTRSTTVTSGFGQRPSLVTDSGSAGLVLGGHYMTPLSSFHLATGSSQPEMPMSGVNVDEIPSTPTDLTALPHPPPLFSAHHRRQRQGGLHRNCGGGVGSSSSRVDWETGVIETDRLERARAVSKDSARTYEIVNEKYVMYDYELGKGSYSTVQLSYNLVDGHFYAVKVLDCARLKRRQLGSEASLCKIDQEITMMKQVQHRNIIALHEVIRDPSMRYVYLVLELAESREVLSMRDNGDVLPRGENAASKAYPEDTTREIVKGLLQALMYAHYLGVAHRDIKPSNVLRTADGTVKLCDFGVSVLAGEVAMQLNREGSVAFLAPELLLSREADVTRSLTPPDSSLSTTQNRSALHILGDDTLASTARTACITVTSTTTTTSAMQLASSVRQASPMEEAATSAPCLTAVFADATLQPSPRATSSRSPQREMASLSGDTSSSIPPQASSVSLPQRDACGDGGAPHQASFRTSSLSPRGTAAPAHGTADVMVSATPCSGYVSAASPLTGTSWTSTPAVQQLGYPLIAVDHTPVDLFKADVFALGVTVYTMLLGQLPWRASSAESQRTAILAEPDPFLRLYKAAYGDAYTWPAKIREACMPCCDMIAGDAFPVTSPATVLASNKDGRSASHGNANYSERSEEPRVCAAEKGNGAAPSRTTALPCKWTQWSSTGASQDECTSGPERCALTATKWVAAPHFYCDVTTRRDPNSVNHVAQYSSKTAGLSCPTSHLLATKATEGSSRALSDLAQARSDDDDSRVEFAASLPPMPQQPPQWKSLVDVSLGSVPIKKATAADTSTTEQAQMTVTHRRGGDSERVEGDLRDKNATRACVTSSTSASTLLPSQFATQTRLGAVMKVSNAHSSCAGEYAAWQSWGAALKGTEDPPPLRPPRPTTTPDQLNMRHHVLKADNGDWTATDVPDAVTSVRESTMEARQWMRRSSSDLLSTVLSTVVSTTVSCSAATSTTSSLSSDDEEDLESCESIYERLFEQEQPCRPYKVAEHMPLPLVPGASREISGDAVDFVRSCLHLDPTERRTVFELFRHPWIRGEEKAGVAELSTSLKLPRRSSSVDENGGDEESSFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNQ4</accession>
    <name>A0A088RNQ4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_201980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698399.1">
        <property type="nucleotide sequence ID" value="XM_010700097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNQ4"/>
    <dbReference type="GeneID" id="22574407"/>
    <dbReference type="KEGG" id="lpan:LPMP_201980"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200025200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201980"/>
    <dbReference type="eggNOG" id="ENOG502S4P7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272578at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="616" mass="66243" checksum="FAB11C21B1B5BB9E" modified="2014-11-26" version="1">MQQVFQEDAARGGEVKPLIRFPLPVELATNLTATGKRSRSSAGMKSATGCSTAASPVTPLTPEERAALCCFIMYGNQSTPASLWFYHHAEKYSTPAQLLASHTGPSRSAVASQHRWCFVALRQAMSLLCRVVRLDSSGFYLHSTSPSKAGVGATAATCGELALSTDAPAESARATTLELYCRFQALELELEDVTLRTEAATQADTVPESVRQQLRSDVEATVVCIKESLNALEDTLVQMLLGSFTDVSVKSASTADMSAAPSLEYVARILRELPSVLQSEQWPAQFICDSDALLTGGGLEPENVGAITSSSTSSLERTLLGTAPVPATDTAMSQLLEQLGGAATSLALRSLFDLCHADVWNLLGVAAASPISRLAALEKLSAETSSGSASAATPCRPVLDVETLEFKEILIRAWNRQYGCVGLRRLFFEMQALFYQLAIHAQATSKLAGGGSGATLGNVCALWGTWRLSLQKRSAAFLAKLGATEKPAAELLDDSTLRVNSCYSMRQHAVPISGVTEVQGMVLRVITKLQAVDTKGWFAVPAFDLVNVDFTSVRHWILTPVFARKSKREAYCCLCRVLERMVDSCVQKYGPTHAFSVVITTVRQQLVDVARTEGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNT5</accession>
    <name>A0A088RNT5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_202360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698439.1">
        <property type="nucleotide sequence ID" value="XM_010700137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNT5"/>
    <dbReference type="GeneID" id="22574445"/>
    <dbReference type="KEGG" id="lpan:LPMP_202360"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_202360"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="79" mass="8735" checksum="C8CD3A3633D02129" modified="2014-11-26" version="1">MPLASFAPLPPLLTIFFFFLLIFFVCCILAVLGAVSLSLSACVLLSWGLAGLRVRALHCARRYSIRTLSDMFAIILRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNV0</accession>
    <name>A0A088RNV0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amastin-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_201290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698330.1">
        <property type="nucleotide sequence ID" value="XM_010700028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNV0"/>
    <dbReference type="GeneID" id="22574338"/>
    <dbReference type="KEGG" id="lpan:LPMP_201290"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000045200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201290"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009944">
        <property type="entry name" value="Amastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297:SF4">
        <property type="entry name" value="AMASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297">
        <property type="entry name" value="AMASTIN-LIKE SURFACE PROTEIN-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07344">
        <property type="entry name" value="Amastin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="160" mass="17858" checksum="ABC693C9D01A9368" modified="2014-11-26" version="1">MEWSIGLLVYVVVQFVAFFLVLVATHIDMFRYRPDGSMLDNECITLWSSKNNCASGKHDISSDGQWAARPPRRDRFRAAQAFVIISIFVYGTAFVLGVIMLLCNRCFRWVCLALNSVGAVTLFIVWVAMAVTYSRNEGFGCLAPKAFHSYGAGFVLLVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNZ2</accession>
    <name>A0A088RNZ2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_161050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN96979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697632.1">
        <property type="nucleotide sequence ID" value="XM_010699330.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22573683"/>
    <dbReference type="KEGG" id="lpan:LPMP_161050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160015300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_161050"/>
    <dbReference type="eggNOG" id="ENOG502SM36">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267484at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037">
        <property type="entry name" value="FORMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037:SF24">
        <property type="entry name" value="POLYCOMB PROTEIN PCL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="295"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="421"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="528"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="642"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="916"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="991"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1087"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1141"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1537"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1930"/>
            <end position="1976"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1990"/>
            <end position="2009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2080"/>
            <end position="2113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2166"/>
            <end position="2194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2228"/>
            <end position="2247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="247"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="438"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="537"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="642"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="675"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1089"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1557"/>
            <end position="1566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1944"/>
            <end position="1957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2099"/>
            <end position="2112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="2175"/>
            <end position="2190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2345" mass="243617" checksum="3D32354AE77A7315" modified="2014-11-26" version="1">MRSIAPPPHDPSSLTLPLRHNARKSAAVSPSLDGSAMDATMPNDQLHLLPISSSPACASTAWYTPSADVTTASQLFDNLGSLQGVDMLANVPISSAAAATGEASSVTSVAQPSALLVPQALDAPPIHMDDHADVCMALRMASATGGSAPVFVPEIAPTKAVDSVSGEVNAPHTSCSQALSPPTATEVLPPYRKGVSDGSSFTCPFVAAAAALQLLPSSFSAMPAPDMSHRTPAALRVGEDGYMQSRFSGHRTTASTPDSQQPPLTDVTHAPLSLLGSSSENSLAAGPTVLSVACGSAPAEEGSGQSSKATEKTSPRRLPIAVLSSKTTSRGTLASDSPHECPLIFSATAAATAQQCGAWRGNRHCNEFHSRRLSRGDAGGSPSVSIKEPRAAAPPLCCAVSDAVADTIVAMLPSAAFTRPSSPYTTFRQPARPRDQASPPPQASTTLLPPPTTKATMPLSASFPAGVALSLDGALRSCVDDVVSVLNMNRSPSLATAVGFGAATAAAGTGTSASLFDSSAGVVVETSAMRQRTRDGALPAQPVQQAPPAKQNPRRSPPSMCSDVLQQSVDARAAVTPVMSADVRTFSPSPQGAARTTTAEVLRRGGHQPQDCGVRCMGGGVLDAPQASTLVEVPAWYPPTLHTNPTGPAADTASQPSHFESESMTYRRALDAATGDNTSTPTDTSATLQDDRPHRNDILNLHSTSCSDVRARFKPMSLEAATRQETSQLCDQSIHDSKGSCCGDAIREAVKETANVATQGTPKVKRLSTPHEGDRVDVQHSAESGGTLIIHRAPASAGIFAHESRCAMQEGGDGAIAVPSHSHQRARHTPTIQSPTSCSIAVVVAYPSSSTGGGSPIPLVATTTPLSAAVAHLPLTVPQPTSAVVLAAEESRDAPRLHVVTSGRLDNTQMSRHSLQVQRLPPTPQPAARTLAPPSSIGSAAPLPHHTEAATDSMSVLPQPPVPGAAPPAQSVANSQTLLTNTRTEFVARSSVAAREAPSPMPTISNSKSPPIVETAHDVPVATAARRFPQLEMLTVPAVDHAHRITAASPPSPAQQRSTAQGELAAPPALPMRYITETACVAQRYTAVSPSRSASRSTPASGGEAVPRVSALSPPCPPGAPVNTSVRAIAAPPYVRDATFKRRHERSTPRSARYRGPPGGSRGDYRAAAHAVSAASAAPPSSFAHVTDGEQVQMKPCRLLMCSSSPPGPPARRPAHAAPLPVCIAVDHVTASLSGVPETIPPCRPLDVRDAGTEGVALSIIPASIGTSGSNVSSPAESELLGVLMDWTPTRLAVSQQRRTAQQEAAEMKVVCGANLEKQWTERTPRAAAAVPVPATQAQALNRRTTLHTGRSCVSNTAATSANPWGGDTRGVSAASALVHHDCQGAQAVLQRVDRRGTVAVTGAPHTSLPARVVPVADSLLSHLTPAPQERRAPPIYSHARGGKVPGALGPITRLPTLWGAAAAPCTRNGRTESGVRSRSQTTTLTLPTSVTTAATHPLPLPSGPSWERIEPLPVEHLPSATPTATLPMARTFPLDSVPSKKTGTPPAVPHRVRASPSLSSCLRQQRSPREAVFTSPKPAPVQHPACPAAAELLRQASLLTAPRQRGEGARNEFASGMTLAASSATSVVQQLACGAASGMPQGAVTWEVLPGTHCSGCGWVSLVSSYPSSAASSCLQRRQLQTGCRSGLPRSLPFLALTPDPMGMAMLSSMPEAAMPRPFSTEAGGHGRRQARPLLWKEPQATQRSSPFTWSCWRGRHTLTSGQRLPERLQPHVHGARTGDFLVELPSNPDMVGDADNAALPRCRPTLSCRATAVAAGRVGTVGDGGELAAIASPIPAAPPSLGLHTVHPAATPERLGGRAGAAAEGDATSGYATAGQPLHRVVAIAPPLPPATAATTEAATPARTYAESVLTRVSNHYSACQHAWQLPSTQSGLPPPSQVFYSQSSQGTGSQSPQDGRGGEARGITGTVSGPRSLPAAEAGMALLHTTAAVDPSEPSPRYPRSRASLQRYSGRTNAALRGADGAINEDKPQRAPRLTRALLDRLQRSHAATAAASSRPHHLPSNLLLEEALVADWHDATQHSSQGGNGASSVPAMAQRPRLSSLSRGRSTRVPAVLPSSEWAAAYSNPVPASPPPQLHAAAGPAPTDIRAESLITVQPEHTAAVQQGPLYRQPYPSPSFSPDPVAPPPAMRDSQGAVLRAPYPQGLSLLVPSHQAPPRRLRRNLVEQPARKPAAHKGTSTANSGPVGLAEMTLEPAKALATPSPLALLEHQRTPVLTAITIVPPAPRPGPWVPEGNRRGLSTEVQSTTETYPRQGSSVQRIRSFFRVFRARQEQRRGGRVWVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RP12</accession>
    <name>A0A088RP12_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_161240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN96999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697652.1">
        <property type="nucleotide sequence ID" value="XM_010699350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RP12"/>
    <dbReference type="GeneID" id="22573703"/>
    <dbReference type="KEGG" id="lpan:LPMP_161240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160017700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_161240"/>
    <dbReference type="eggNOG" id="ENOG502S6UZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="238709at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="99" mass="11550" checksum="DFBD3B558E99140A" modified="2014-11-26" version="1">MGIQIPWLFVCVSTVPVFMIYTKTKRMDAREMHEIQMRIKYHSEYWKKGNVFVKEFQDKVATQVMRTADPLVGKDIASISAKELAAAENPARARRWLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RP84</accession>
    <name>A0A088RP84_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sjogren s syndrome nuclear autoantigen 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_204130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698614.1">
        <property type="nucleotide sequence ID" value="XM_010700312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RP84"/>
    <dbReference type="GeneID" id="22574624"/>
    <dbReference type="KEGG" id="lpan:LPMP_204130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200047400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_204130"/>
    <dbReference type="eggNOG" id="ENOG502TNA7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="295355at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033362">
        <property type="entry name" value="SSNA1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28661:SF1">
        <property type="entry name" value="MICROTUBULE NUCLEATION FACTOR SSNA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28661">
        <property type="entry name" value="SJOEGREN SYNDROME NUCLEAR AUTOANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="12"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="11934" checksum="F20E88701AE88F76" modified="2014-11-26" version="1">MAALGSDVQATSVELVSVIEKMKERKARLEEQISAEEAEYEGLLAEVRTMQERLAALRDSVAKKQAVRADLERTISETYSAFKSILDASKKLLSTAKEESSALKSQIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPC3</accession>
    <name>A0A088RPC3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">P-type Cu(+) transporter</fullName>
            <ecNumber evidence="2">7.2.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">LPMP_170560</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="7.2.2.8" evidence="2"/>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697747.1">
        <property type="nucleotide sequence ID" value="XM_010699445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPC3"/>
    <dbReference type="GeneID" id="22573799"/>
    <dbReference type="KEGG" id="lpan:LPMP_170560"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170011200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_170560"/>
    <dbReference type="eggNOG" id="KOG0204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140581">
        <property type="term" value="F:P-type monovalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000029">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000144">
        <property type="entry name" value="copper-transporting ATPase 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0186">Copper</keyword>
    <keyword evidence="7" id="KW-0187">Copper transport</keyword>
    <keyword evidence="19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="244"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="911"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="944"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="17">
        <location>
            <begin position="84"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="18">
        <location>
            <begin position="793"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="554"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AIN97094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1032" mass="111497" checksum="3123DB7128726919" modified="2014-11-26" version="1">MSFLDMVWESLEDRMVQILIASAVISLVLGLTVPDQDTGLVNYAHGWIEGTAILLSVTIITLVSSINNYQKEQKFKELSKATPPVKVQVVRSGATLDITDKELLSGDLLNIAAGDVLTVDGLVLRSTSLKVDESAATGENDDVAKSAHGDFVLRSGSNVTEGEGTILVMGVGVHSFAGHIAMQVREPKEETPLQEKLEALANLIGYMGMAAAGLMFVLLSGKELLDTLVYRKHPFDYKKYLDNLTTAVTIVVVAVPEGLPLSVTIALAYSMKQMFKENNLVRHLAACETMGSATTICTDKTGTITQNDMVVTDGVTAYGVAYVVPRKRSTFVGEGERMCSGTPSPLSPLLQMPTSMDVSAVLGGAQAAGVRRLLMECIAMNTKSTRVLVESPNATHAVVQLTGSKTEQALLNFVDALGEDPMQLRSERLSRLNEEAIYTPSSPFALVPWPTGNAGASSNIMAAAATFTKDLRIYPFTSVRKRMATALVLRPEKVVRYYVKGASELILAECTHTYDEQGKRVGLSHEVRVRLEEAIMAMARRQLRTLAIAYTDHPLSPPGSATPRGSSDSDEGGAASSLPFLEDDTQLSGLTLVGIVGIRDPVRLEVPGAVEQCRRAGVIVRMITGDNKATAVSIAKEVGIYGEVWSGAAKGEQGLALEGSQFRELAKSARKLNAILPRLQVISRASPLDKRILVSALMERGEVVAVTGDGTNDAPALKGANVGFSMNSGTAVAKLASDVVILDDNFNTIVTAMKWGRNVNDNISKFLQFQMTVNLAAVVVSFLGALLDRNGESPLKPVQLLWVNLIMDTLAALALATETPSDEVLLRPPKPKAAPLITRRMWLNIVGQSLYQILIQQYLLLGGVSTLGLAMRNTEELHTLVFNVFVLMQLSNEFNARILDNTVTFWHNLSHAPMFIAVVGTTLAIQIFSVQYGGTLMQCVPLSLASWMTSFALGVVPLFIGFALRRIRVAEKDIPPPPPVVDMKEAALRLALKQRVHPTLRIAAGKVRMQLQVLKAFRENAQEQKAARTRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPE2</accession>
    <name>A0A088RPE2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tyrosine phosphatase isoform, putative</fullName>
            <ecNumber evidence="6">3.1.3.48</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_201510</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.48" evidence="6"/>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698352.1">
        <property type="nucleotide sequence ID" value="XM_010700050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPE2"/>
    <dbReference type="GeneID" id="22574360"/>
    <dbReference type="KEGG" id="lpan:LPMP_201510"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200020300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201510"/>
    <dbReference type="eggNOG" id="KOG2283">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="16692at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016314">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051281">
        <property type="entry name" value="Dual-spec_lipid-protein_phosph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057023">
        <property type="entry name" value="PTP-SAK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014020">
        <property type="entry name" value="Tensin_C2-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029023">
        <property type="entry name" value="Tensin_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305">
        <property type="entry name" value="PHOSPHATASE WITH HOMOLOGY TO TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305:SF60">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE TPTE2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10409">
        <property type="entry name" value="PTEN_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22784">
        <property type="entry name" value="PTP-SAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01326">
        <property type="entry name" value="PTEN_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51182">
        <property type="entry name" value="C2_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51181">
        <property type="entry name" value="PPASE_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase tensin-type" evidence="4">
        <location>
            <begin position="198"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="303"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="C2 tensin-type" evidence="5">
        <location>
            <begin position="379"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN97645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="576" mass="66391" checksum="D292CA0A1185FA8F" modified="2014-11-26" version="1">MNSEPVDTNPLVPTTLYEKVTYYLRDRTKYLHVQNEIPLEVTNKLAMVNNYYVSVADPQDMSFTNSGEHTADHVCWVVYNFFLRLYVQAALLVPTLLFLLFIAVQTHHSPTFLLLYSLVIDVEVLSMWAYERGARFAAGHWWELVWLIIGLVVVNIHVLYPANVLCALLLVVHWMFMARITVIQVSRALRVFCASDRRCYIAEGVVLDMAYITRNLLAMGWPAKGTEAFYRNPWRNVVDFLHRKYARLSSHVITLCSERCTEPFPRQSTYPVDDHNPAEMPLMISFCCEVADYVMADPYNRVVAVHCKGGKGRTGTMICAYLMYCGQCRSADAALRHFSLLRSRIGAQKLQGVQTPSQERYVRYFEHLINEHPGMVIPSHPRRVRRLELHTIPQLWVLHGVEHLWMTVIVKPCTERRIVYLTNRTVTFNSAVPDPRTYNWRTQIKDLFHSDEEVIYQEANEMDAAESGSTGYRPDQRSFRVIGEAGDVLQLAFPEEIPVVDGDVCFKFFFFKNNPNPLLPPVQFWIHTGLEKHSTIRLERSDLDGPSKDTKGLRYSADFAVELVLEDAQVEKAERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPS5</accession>
    <name>A0A088RPS5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_204750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698675.1">
        <property type="nucleotide sequence ID" value="XM_010700373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPS5"/>
    <dbReference type="GeneID" id="22574687"/>
    <dbReference type="KEGG" id="lpan:LPMP_204750"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200054200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_204750"/>
    <dbReference type="eggNOG" id="ENOG502QTN5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275172at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="429" mass="50237" checksum="0B9AC64F14FC0785" modified="2014-11-26" version="1">MLSHTAVWLRVLSRKNKTPQRMSNFTKVTNLNKAEKAKIETIDGDVVKGRGRVHRRSHSGLKDAIEAMEHPAIWLWYPWRKNPEPPTPYMPSQRALKNVHGAIFADLTPIQKKKQEQMLYGVNIPETRVMRFEQQHPLLAMALKQLDGQPKGFPFWYKKYPTRRHAYEQRFSVPPEMLEGYSDSIKKAFGKDMMTIQEKQFSQEAMYMERYAEHDFDTTSPAVLAVKRALKVRVLRNHLLTNPHNNIVKTILANTERKLNHTLRRLRKVDFKRYWEIIRDHDVQDVLQPPNLVTYRQGSYWRYDWNAGLAISTQLADVLDPRGLNGCVETGRSRSEVARDLGLSYTRPLQENEKKQLSEQAVYYERLAKFKMEQPEAARAQERERFVRKFSGMFLKLDIKSGVPDFPSTYRKLLGTQVARWSSKRHGPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPT9</accession>
    <name>A0A088RPT9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_180580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase C subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697892.1">
        <property type="nucleotide sequence ID" value="XM_010699590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPT9"/>
    <dbReference type="GeneID" id="22573948"/>
    <dbReference type="KEGG" id="lpan:LPMP_180580"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180009500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_180580"/>
    <dbReference type="eggNOG" id="KOG2909">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6605928at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14785">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1460.10">
        <property type="entry name" value="subunit c (vma5p) of the yeast v-atpase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1180">
        <property type="entry name" value="Vacuolar atp synthase subunit c, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004907">
        <property type="entry name" value="ATPase_V1-cplx_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036132">
        <property type="entry name" value="Vac_ATP_synth_c_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03223">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118203">
        <property type="entry name" value="Vacuolar ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN97239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="412" mass="47462" checksum="234F72B7098152AB" modified="2014-11-26" version="1">MVLEYVIFYSLKTNPLSVLQKAFTGRVVFLREMSESFLILALPYLQHSQDSLQSAQYEALVRHMGPLGQTFRHFVIPSLKVGTLDSLMEASDELAKLDPIMENTLQKLIGLMEETSGKPRSVVTTFRINQTQEMSSAGYVKNFLWSTAQFDPKETIQSLIEKFARINTTADERVRAMLAEYNDTRNKLIAANRKGEGNLSIRPIRELVALYNRNYQCFVDTELLVTVFVAVPSAAQREWLATYWKMNEYVCPQSNRMVAEDKEYVLNSIVMFRKVMDDVKMACRKKRYVIREVEGTDELSFAELKKLQQKAEKEKKALYTLLWQQYCTCYVAWIHLKAVRVFIEALLKFGLPPRFIAVVLQVPVDKEAEIRKRIAQVYPDLTTPLANDVIVDTGALQQEYPYVSLKVTNMQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPW9</accession>
    <name>A0A088RPW9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallo-dependent phosphatase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_181030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697937.1">
        <property type="nucleotide sequence ID" value="XM_010699635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPW9"/>
    <dbReference type="GeneID" id="22573993"/>
    <dbReference type="KEGG" id="lpan:LPMP_181030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180013300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_181030"/>
    <dbReference type="eggNOG" id="ENOG502QTGZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10266805at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33987">
        <property type="entry name" value="CALCINEURIN-LIKE METALLO-PHOSPHOESTERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33987:SF1">
        <property type="entry name" value="CALCINEURIN-LIKE METALLO-PHOSPHOESTERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="764"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="681"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="801"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="823" mass="91660" checksum="363B3EC5BB337DE2" modified="2014-11-26" version="1">MRRRVVGSEGLKGHVGAAAPIWRSRQSRRTFLAVLLLPIALLAVGCLLLILNRIADNGSTPASVKDFAMDDAWWNPDNRQEEWQRALLYSEQLNLPASHSLAINQVFFISCNRHDLSQLYWAYMAVAAQCEMLSRVNATAAPPCRKLYAGLSPLIPTANAAAPSSERHRRMADTDEGAWAEEVPLGACGSVYDSPKAAMQRLRYRWTPPPGLLLDETPPPVHPHPGPERRFQSAPRGAAYSASVPVDALIWLGDAIYADKIPDGKSTQSLLFPHTNSMVEVERFWKIQRDALEYNAFIDSCVAGGDNVDWNLHSPNQRFLSAAESNRTRVMQASPDAYPKVWGTWDDHDMGMNDAGREYPNRNSTQAFFLDFLRAPSSDPRWHREGVYGAYTTDFSDVVDDTKGWGTPVRLLMQQLYEHAICAVLLDARSFRDSPNATHAGDAIGAEQWVWFEESLKNYTTPTQDGRERCAMVLIGSGIQFMLDEKPAENWAAFPRSRDRLLGLLRAYRVERVAFITGDVHMGELGADFTEHAIGEVFGYPIVEVTSSGLTHSANMYFLPTLMPLLFPSSRRVGLYVGENFGALRLSIDLHHLPSIRSYLTDIERAMGTGAAANESAARSPTPQWRREARAAVEQVLNATFTIFSIPNGGQPVYRLNFPLSMLTYAHGPAYRDARVNAVHGSVHKEPTTSPTAPKENGGYEAANGGTERTPSLSLRSTLTLTNGTITHIAHYKDTEPAPFITWSARQFQYYVFTTFSVSETLKAMILLDALVVVLVLLLLILRLYRCLWRQRSSGDRLPHCNVEASPHASPMMRGRNKTRRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQE0</accession>
    <name>A0A088RQE0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S Ribosomal protein L36, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_210770</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL36 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698865.1">
        <property type="nucleotide sequence ID" value="XM_010700563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQE0"/>
    <dbReference type="GeneID" id="22574899"/>
    <dbReference type="KEGG" id="lpan:LPMP_210770"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210012400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_210770"/>
    <dbReference type="eggNOG" id="KOG3452">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276730at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1760:FF:000001">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1760">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000509">
        <property type="entry name" value="Ribosomal_eL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038097">
        <property type="entry name" value="Ribosomal_eL36_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10114">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01158">
        <property type="entry name" value="Ribosomal_L36e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN98158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="105" mass="11991" checksum="FFB91782B27F738A" modified="2014-11-26" version="1">MSAPTPRTGIVAGFNKGHVTTRRPRQPSPNDRFSVPHKRLRAVKAIIADLVGLSPLEKRVQEFLRVGKEKRALKYCKKRLGDFTAAKKKRSKMEEALRHVTKKHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQK4</accession>
    <name>A0A088RQK4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Structural maintenance of chromosomes protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LPMP_211550</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC4 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698940.1">
        <property type="nucleotide sequence ID" value="XM_010700638.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22574977"/>
    <dbReference type="KEGG" id="lpan:LPMP_211550"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210020100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_211550"/>
    <dbReference type="eggNOG" id="KOG0996">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5575062at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000481">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000585">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1060.20:FF:000011">
        <property type="entry name" value="Structural maintenance of chromosomes protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1620:FF:000017">
        <property type="entry name" value="Structural maintenance of chromosomes protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF172">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="14">
        <location>
            <begin position="697"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="814"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1164"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1483"/>
            <end position="1561"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="882"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="946"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="822"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1180"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1527"/>
            <end position="1544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1547"/>
            <end position="1559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AIN98233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1588" mass="177496" checksum="7C4DA5F7F7246B28" modified="2014-11-26" version="1">MPPRKKGARKARSVATKRHAERTQVSVKEECREDEEAGDVHTEDSHMETFAEKFHREEEEWRRAEDRLEDVDRDDGEAPLGSREGSQEAPEDEPAQEAVGHGPEDGGGSDDSASSSSSAARLSTYTPPHVSSTRTSGTELELIHSVMTVTHPSQRTVAQSDSTGGDLTPHSRLVIRDIDVENFKSYYGTHRIGPFHKTFTAVIGPNGSGKSNVIDSMLFVFGRNAKKIRLDKLAEVIHNSAAHPNLSYASVTVNFIRLLETTAEEKDSEQRQEVGGSGLSIKREVFRTGASQYYIDGARRTQKEVMECLIAQGVDLDHNRFLILQGEVEQIALMKPKAEKEGEEGLLEYLDDLIGTSQFVGRISDMTAAAETAQLARLEALDKERKLKAEREALDEAKNSTLSFVTKDNQLQKTLIVMCQLRMRGIEERLEEPRRLLAEIDERIELMEKEVVQRRIEKAKAEEASAAAKRHVAEVQRARDALRAQRQSAEVHLEHVKSGADQEEKARKKAADQLRKAKEELQRAVLHQQDAEREAAIHQQNYKEATETISTLQREHDTLSEELLPKLRPLRQQLEEKKEQLAPYKRAVMEAKEQLRTVQSRLGGLADSATKKQQQVADLAASTGRSKTRMAELERLLRDADRKDLQEEVLQVQDQIGESARRKYAINNSIQELKNAYRDGEADDRAMEFLLAQRSLKGYYGTLRQLGRIDDKYDVAAGVASNAWGFHVVEDRQTATAALQLLKQNNIGRATMMVVSEVEREVGSRMAKPFQCPNPKARRLFDLIQPTNAKFRSVFYQAVRDTLVVETLTEARETAFGGGGSSRTTAKASSSSFSPAGGTANQQRYRVVTVKGELVEPSGAITGGGAAPRGAKLKAARSPQDKQSIKEDLQRLQQDLVQAAEEERALNVRLHQLHEQESHLYPEQLRQLRHELTTLVAKADGDAARLASLRGELAQSMQELEGKRAQCEQAVEDCEAALQKAEKTYIAHHADVEALEAQVDEAGGARFRTVAASLATQQERADAEEASLRACRRQAQKHRATQERKTADIADYEHQLKKLEEEAQDNVKEKMRECVEVLEELMKELNGAEARLANAQAAAEDARAAVPVANGAALNAQKKLDDEQRYRQTEAVKIADALQELSKFQQKIEGCEEKIRENAELYGKETLGQGDAGDVKDQDAEVDDEDDEEEECETAYSRKRARARPSRSPNETALQTSSGGGSSAFVPPPPKRAHVELRHMTFRLTPEELDACDYDRSVHLAKALSEETKRLHSEIDFRAVALWRERDVAHREAKAFYEAKKLLSDEAERGLQTLKDTRRQAFMNAFELIRQRLKEVYQLLTHGGDADMELVDVNDPFEGIHFVVRPPKKSWKQISNLSGGEKTLSSLALIFSLHYIKPTPIYVMDEIDAALDFRNVSIVANYVLRQARGAQFIIISLRNNMFEEAHQLVGVCKVNDTTSTLVLMPRNFRRLVGTQLAEAAAVQRSQHSERHRSRHQPVEATVARNPDQGDVDGHACRPRTSIVYQPHTPSSGARSTVSDASPISASERLRSSGDMDDSHHSRKSIRFTDFNSVTAAATAEDHHAHCVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQS0</accession>
    <name>A0A088RQS0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_211050</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698892.1">
        <property type="nucleotide sequence ID" value="XM_010700590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQS0"/>
    <dbReference type="GeneID" id="22574927"/>
    <dbReference type="KEGG" id="lpan:LPMP_211050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210014500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_211050"/>
    <dbReference type="eggNOG" id="KOG0065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF91">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="638"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="672"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="724"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="756"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="786"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="914"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="95"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="346"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="446"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN98185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="945" mass="101004" checksum="7EB7CABAC3B750DC" modified="2014-11-26" version="1">MNASQSFFTPVVSSSSSNSNSITEAPPHHHRHCASLAPRDSAGSTATEHPADNTDDTLLVVSTKTPLSQRLRTRHSRRSNADCFAGDSESPLGVVRATDLTLCCDSVSVQLNQRDVIDEVSCLFRGGRVTAVVNCCGTHTAFALLAVMAGMLESAAGNVVLNGIPVSASTYQAQTSFLEDGGEISRKEEESSSSATVASDGLLVELTVRENLQYTSALRVANSAQAYSVEEVLQQLLLRPHETSKIKDCSLYVRRRVALGRALLLNPSVLLLDEPLEGLATHESQQYLTILSKLAAPSVADAEARHVMRQAMSAAAAAAAGEGGASTRVTVNLATTSGAGNVSLYTPRHSRLRFGPPARQSTPRPASPTDAPITTAATSTDLASRAEAQRIVVLSMVQPRWALLQYVHDVVLLERSRCIFAGSVRDMLAVKLPKDVMRASMAARANGGGELTDEPGSRAAGTAAAVPSTPPRNLFTAAPANSYDAVDASIQHQRLGERIVHGLYRLATSTTAPAVGDDGSESDEGDAAAAAESGFAPIINAEGHSDAPVSRRSVAAALAASASSSLFIGVNADGPPATALSHMYAHRQARMRASVTAYMEACAMGLVELPEVFHESPSSVVQLLHLLRFGFLELRRNFIWNIFSLVCGLALTSVLAALYGRQGGQEGMQNRVGIVFFLVSCVVLQAVLSLDALRREYATFQRYTVSGYYGVWTYLVFRAITAALWRFGLASFVALAVFVLSNFGDPWHEYRGIFELSVILAVTSFCSHFGVWFLCTWLPSDHVGRFVVFTFYTLNIILAGLVLNLQTLPDAVRAISFASVVRLAYESCILTQFIGKSFGCHDDGTAGANGASPRVTTAAPLGSNASAHQNGRASSLSMQGALRTLAAVQTTACYTGSEYAEFLGFNPSRRWSNVAVLAVMSALLLMGSWIMMALNRPRRRFKMHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQV8</accession>
    <name>A0A088RQV8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_211720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698957.1">
        <property type="nucleotide sequence ID" value="XM_010700655.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22574994"/>
    <dbReference type="KEGG" id="lpan:LPMP_211720"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210021200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_211720"/>
    <dbReference type="eggNOG" id="ENOG502S90B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266011at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48447">
        <property type="entry name" value="REVERSE TRANSCRIPTASE ZINC-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48447:SF1">
        <property type="entry name" value="REVERSE TRANSCRIPTASE ZINC-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="709"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="893"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="714"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="893"/>
            <end position="906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1371" mass="143802" checksum="DEC20A74820AA4E5" modified="2014-11-26" version="1">MKLTATNSATAAAVPGDDCSHYHSHHHRHDAAVPRRTDTAQHTCFYFTVFFSNNPPIFHSNRIPLEKLDVGALMSPTRARERAGQLVSEESADGLAGSALPSSSFSQCTSCQQQYWKTIFGELGADCVTRRGVGHTCASTQYAAGASAGEDRGGAVPVVEDYRSASATVEEVPQQTLQNVAFPTTFGCCGGACALPLRASGRRMRCTSAALTPMMPPPEVAVSSKVSFSKREASQLLQLPSAADTKNVRAYNAKTLMQESDCGCAQARAPELTESLSSTVETFPLSDTTTSVNDPSTSETVTWALTTSDHLKVALPSLKHKYRDTVAVCSHHNEDATATTISTAPQAHITPTIPNRAEPKALPQGSMATEAPTPAQRDATYSAARAPAARLITSPTTPVPKTLETRNATHSTPLPLAADTSADLSTSMNDTCSAPPAASAPMQEGPPWNMKVEEVRSAKGELRYYRIILTVSFTALVTTHTGLMHSMQTRNAATALVVLCPPCGVHFRFLLNHMDVLRSVLNRTTEFAIRTVQRFFGLLYSPTQRPKGSQQQALKAIATLLEAHPEALATYRAVKAELTNALCLRFPLPVLTPATSAWAVPVLTRSSLFSARTRSGSKGVSVKSPSGSCDARATSMSWVGSDGASASVGRMSGAGAPPSGSPRAAPLILADILHEATSFVREYSEGFASAFICGLLSLTESGFGSAGLRARSRGSNSASPTAGATTATPTVSNLTSPNVNGVSQLLNCVPSSSSPTTAHEASACFAGCGGVAAAGSRGAPEWLSPYAAYWSSLTANCSPLHIGDDDVINFGKPTSAKLEGYGHASTSSSVDHVDDGAVTTHVSTSKISPKAPSVSPLAGDVPYLASAPSGSLESHSPSPAARRTAADLLAAPSAAAAVPPSPTRAAGSSTAPSTSKEDEYLLHRGRLGRVVIFTQDSTLARRLLVIAAFLWSGCGCGAVIGGGIAMRSGAPCRAATSGQQRVARSAAEDVALRNEEAQHMYETAVAAAVSSTEYANVPVQWVAEEFSEPRLCSLCSRFSPENTLLVVVPRQLQCRLVYLRKYVTSTTVLVEEHSGKGARICTAPFPFRCLISKQVVVRPDPTVTTLLREACSLHKNSHGTVSFTDVFQRMVGWLHWQSAAVLAREAHARAAAAATMANGAPLIRFVSTDAVWLSTEISIRSPSASSGTRDNNGSHAATPLAVSAEILQTRSTNKLASSLAHRCDSSWEYESVEEALLPGSMGGAGGCSFIANVHTKAAGGEAAASAIPAFRSGTTPVTSMLLVSHGLLKPPSAFTSASPTSANPTKATSFSPLKRFYRFRSSPTSTSAETTQSHPILSPVTLGQMYSSKGAVGRQLSHLLAGDNDEADILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RR51</accession>
    <name>A0A088RR51_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vps36-like protein sorting protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_201550</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698356.1">
        <property type="nucleotide sequence ID" value="XM_010700054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RR51"/>
    <dbReference type="GeneID" id="22574364"/>
    <dbReference type="KEGG" id="lpan:LPMP_201550"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200020700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201550"/>
    <dbReference type="eggNOG" id="KOG3341">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="283883at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016689">
        <property type="entry name" value="ESCRT-2_cplx_Snf8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806">
        <property type="entry name" value="EAP30 SUBUNIT OF ELL COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806:SF0">
        <property type="entry name" value="VACUOLAR-SORTING PROTEIN SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="234"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="328"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="25"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN97649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="395" mass="43349" checksum="8CB45FF7EE1E3271" modified="2014-11-26" version="1">MRRRVGVGHVLQERQQQQRMADLGAQITAERVGQIEDQLEELQAQLKTLAQNHKSDITEDPVVRARFRQLADSLGVDLLSSKKNVFADALGLGNFYYQLASRTVEACMRERKFCGAYVPLQRVQLFVQKTYDNSSLLCGNGQSRHVSPHRSGRSSSSGKHGGRDEGKRIVISEADILTALSKLSVLGVGFNVVKLDGIPYIQTTPDGARGGDQVLLLNYVLGLQKEQIEKAKRTAVQEQSKSMPTSSVNNSWTAAEGGSNQRNGVGAVYALGAHPFAFEKDKSSQANDTLSFAQQCVAVRESEIVSGLHWETHRARAALRRMVQEGTAWVEESQDRPGDRATKTGAHGDSPGKSKAVLSSFEEVKVVWKGKHKGTTEASDKDNVVYWFVSLTSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RR63</accession>
    <name>A0A088RR63_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">IQ calmodulin-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_201700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698371.1">
        <property type="nucleotide sequence ID" value="XM_010700069.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22574379"/>
    <dbReference type="KEGG" id="lpan:LPMP_201700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200022300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201700"/>
    <dbReference type="eggNOG" id="ENOG502RH9R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="250126at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051295">
        <property type="term" value="P:establishment of meiotic spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007051">
        <property type="term" value="P:spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051185">
        <property type="entry name" value="ASPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22706">
        <property type="entry name" value="ASSEMBLY FACTOR FOR SPINDLE MICROTUBULES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22706:SF1">
        <property type="entry name" value="ASSEMBLY FACTOR FOR SPINDLE MICROTUBULES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="102"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="649"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="657"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN97664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1337" mass="149015" checksum="A5B2CA4BD021C409" modified="2014-11-26" version="1">MEVRERSQSRNVLALMCTSYTDDNEKNVRFPHALPPLSFLLPHSSTKPLRTHANAHTHTQRVRPSSFAGASPPCCVYNSSHHLRAGQGSELFVLEITMKSVRQSGRHGNKDAKLRSKRTYRGRYDQAPRSSPRYAAASASPSPVAPLVPPTAHQLQSAPLLAFTRWNETAMEALRSGDHDSCRRILSTLLPILEARLHAMQCKPSPHISEAALQSWRLAHALTLNNHGCQLRRYGRTTEALQAFLRAKEIETLVLGKPSCSTMLNLSAVLLSSGAAEEALTISKECVMAAQNGGPILFITAVHNLAVALGQQTSDRECKAALPTMLQALREAQSVLGEEHPTTVMLKEKCGLTSSWISQDSGAEGEQGSAASVRGVDWPAHHSVSCENPTSPSLLPTSMMAQEKARAALHTLDFGEPLHAQPLVHAAAALPTPELVHNHINERKEEAYGVSISRHSLSLGAPNEHHAAKATPEDEDLLCPQRPRSTLLDSVADAGVERAALAVTARGETALALPLQGFQRRGSVAASVHQLCLDSANISGNQRSVASTPLETVLQEPFQAASLMLSRSAPNHVGPAGSIHRLWRRSAEDHRNAPSFLRFSVPLPPLPANAASLPLRKIAPPAAAAGSSNAGVQCRCTKVRRATVPRNVSVSDEDSNLGGTTATTLTDTMPTTEGLNAFDTGEKSATAIGSPATLRSAPQLSLFGKKGLLHSGKAALREVELEEERVYRAQKEVEQRAAEAENAFQCSFKEIQLRTQNRAALTIQHAWQQWWTSVGRSRRHVQLKRLEELQRRRRERLSLGAMDRKKSGKSWTVAIPPPLLQQHGHVGGHVVPAVIVRCSRTWLAKTVCRRYVAKSHPRPVDTRLHEADVRRCVCQIQALWRGAITRHRQAQQQLFTERDNVRGVTTVYRLRAETELREYSALVLQMVYRSYRARQIRCRLYFERYNEPAATIQRWLRSTLADQRKRGVDWRSMCEHNAAATAIQRVWRGYLGRITFHMRELRLRMDRAGSYPLAIEASVNAGRRLVAIRGGKSRDVKCLSVETMKPPPDAAMKMEGPLPPVREVDAPVAEATAFESKRRSALTEAYAADCLQRSSEVQRWRDEERDRYHIGLYVDVMASKERQAWKESLRIRPSKVLRCRAAMDARIHEEQRAFTEQCAALVIQHAYRTWWKMQQDTSRDTSLLCYARALYQQRELGALVERKQRRRDIVRGMALYGDTAAAMRQARVKAAEELALVADYDGPPCISSSPNRVMTIPRKDGMMIAPHAERMARKQQRQEQEAVQRRDEVLVALTYPHDMAHVREGPVECVTRIGTTYEHPYYISYVNEVHRRTLGID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RR71</accession>
    <name>A0A088RR71_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallo-dependent hydrolase/oxidoreductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_221020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699102.1">
        <property type="nucleotide sequence ID" value="XM_010700800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RR71"/>
    <dbReference type="GeneID" id="22575148"/>
    <dbReference type="KEGG" id="lpan:LPMP_221020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220013600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_221020"/>
    <dbReference type="eggNOG" id="ENOG502QWBK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="341300at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42663:SF6">
        <property type="entry name" value="HYDROLASE C777.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42663">
        <property type="entry name" value="HYDROLASE C777.06C-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="144"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="470" mass="50500" checksum="C97B961FA51EB315" modified="2014-11-26" version="1">MSSAFAIRHSHIASQPVQAPPPGYMSLTVVGSGVSTGVPVIGHLGLGCACEDAVADPSGPNSRNNISLLITLPRGDLPDLPEVRTASTTATMPVADQMKAENDGGNGSGGTAGAVRNTTPRPSHSCFAVERSSNYIGAKPVAHILIDCGKTFRDAYFKVMIRCNIRAVDTLLLTHGHADAVAGLDDLRDLQSMHMVSTGDWVVDSFVPTYLSRSTLKTLEKSVDYIIRNSIKSGHAASTPTEHAARLAECLQQREAQAVANGTAHKVGKWRNIGIRRSTALELFCMDEERPLRMHLPITTTAAMADGTAAAPSDLPFYSFPVEHGKGYISMAWVFGRGTAFKSQQTQQQGQHQPEGSCVVYISDVSDVPATSMAFLQDLVKIDVLFVDCLSPTGRVSPVHYCEDGMMALVLALKPRYVFGVGMHCALEHFKWMAELQKALDSHVAAGRLRAGEVQGVELSYDGMQVLLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RR92</accession>
    <name>A0A088RR92_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Intraflagellar transport protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_221250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699127.1">
        <property type="nucleotide sequence ID" value="XM_010700825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RR92"/>
    <dbReference type="GeneID" id="22575171"/>
    <dbReference type="KEGG" id="lpan:LPMP_221250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220016200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_221250"/>
    <dbReference type="eggNOG" id="ENOG502QS4E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="444379at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035735">
        <property type="term" value="P:intraciliary transport involved in cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029602">
        <property type="entry name" value="IFT74"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31432">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 74 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31432:SF0">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 74 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="33"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="229"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="310"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="536" mass="61489" checksum="1A250EB4421F5D0C" modified="2014-11-26" version="1">MRAASRSGVGTSAGPGRQVGDRSYYIGLIRPKIAELSAEIERLQEQEQLIDRNSSVLTQLQQKSRSLQDDIAKLKDALADANVAVENSSSRDLAAVKDESTRLAKQNIAQRKRVDDLFLAVKDTDAKTKATLQLLEEEIQQLDRRILNENQDYHSYTAIRDEAFAVSDMVLDRQHELRTLHAKQDFLMANLADDPDKKRAAEMLRGILRKRRERKELQSQCSLSVKEEQEKLIGQLKAARSDIEVLERQVNDIRDTLQESRARQSALEEEVKNFSGENVQAFQELQEKDREMQIFIDEYPDKERAELDKIAEAQKNIADLLSRISQALEMQRQMPTENSADTLHNLATQVDAKRDQIQNDVKTHQRLEKELLERKVELDKVAHLDKKIKEELSSHSAKMAEQKVEMERFSDLAGLRVEVEDTRNVLNGQLAYYTRLRDGSKQQLNALTAQYEARKKELHTNDVFTTLSTQEQRIRMLWQSTFSLEDYVRLKEKDTQYLSTKAECLRIVDEVNLQLQNPSRIAGMGAAPLFSATSTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRP1</accession>
    <name>A0A088RRP1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">H/ACA ribonucleoprotein complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_204050</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the GAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698606.1">
        <property type="nucleotide sequence ID" value="XM_010700304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRP1"/>
    <dbReference type="GeneID" id="22574616"/>
    <dbReference type="KEGG" id="lpan:LPMP_204050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200046600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_204050"/>
    <dbReference type="eggNOG" id="KOG3262">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2187159at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034513">
        <property type="term" value="F:box H/ACA snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000454">
        <property type="term" value="P:snoRNA guided rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.230:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237:SF6">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237">
        <property type="entry name" value="NUCLEOLAR PROTEIN FAMILY A MEMBER 1 SNORNP PROTEIN GAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="129"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="158"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN97899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="220" mass="21789" checksum="FAED12932BE32FBF" modified="2014-11-26" version="1">MARGFGGRGGGDRGGGGRGFGGPRGGGFGGGRGGHMSESDPPENVEEVGTFMSAAEGELVYKVTVHGQVPRFNAFVYTENKAKIGKIEEILGNTTDVMFSVKPSPGVQAASLSEGDKAYISTLQFTPLRAFTDPPKPRGRGGRGAGRGGGRGGDRGGRGGFGNARGGFGGRGGFGGRGGFGGRGGFGGAGGGRGSFGGGGRGNFGGGSRGRGFDGRGRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSL4</accession>
    <name>A0A088RSL4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_251060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699675.1">
        <property type="nucleotide sequence ID" value="XM_010701373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSL4"/>
    <dbReference type="GeneID" id="22575754"/>
    <dbReference type="KEGG" id="lpan:LPMP_251060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250016800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_251060"/>
    <dbReference type="eggNOG" id="ENOG502S6EY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="239992at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="567"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="756"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="839"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN98968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="876" mass="95199" checksum="2BA08EB5A9AE376F" modified="2014-11-26" version="1">MSVSTEEESELTDLVAQSQLSKRLAENSPAASSEVAPQSVAGVQQPAWHEHEGHLRESHSSLAGLMNHPLEQEAHEPIVFDQPMDTTPILLRSFDELLISATAAKEQGRINKHQCALAVRRLRLISFTLHQMPQPAPSQQLLTAMKSLCLLLRQCAHDGGAGTNTAEPITALQMLYGPDGDPLGPAQCWPALLFQHFTSRLLFQSAYRRLWAAWSMYSHVGLEKEDTVAESLDSAEDAKVMMERLFPMGVPGGQADHSTSEEADSVSQHKRDLLAYYQRRNMSPWRILYQDLEPTDQHVPEASRPQGVSPLAATGHGAGEEEEEKEDVCFRVVPHVYRYNGVPVVVKALCGAAGTGEAEVQKAAMQHAGEFVLDVGCRATWCHPHIVTCLGGYTEKFVDNMERPEVSAGRGGTMVAAENHGDAAVEGVEVSKKATEERSASAAAVTLPWQRAVSTATGRPIMALGYVLELQSASLASTAATAAQTSYVTLRDLLFASPFSATSSSAPLSMVRRRNFTLYEALDICAQIADALQYIMDDSHEVSEAVRTAWLTIDPANIFVVRVVEPKGGEEPRPQQPKKPYGGGSGDQHGRKSSPLSINGESAVWAARVTSLAEGNSREGAADVMGQSDPQRRFLKAWEDGGGHVDASFGDVVDAAQTPKGWVTEVYVSQGRKNDCDNTEDVLHCQSKHFVVRYSPPCSWTPHEVAGSRWRPHARATAPASYAVVQLFLALLTGQVPYAHMKTDREVEERVFAGTTQHPGNMWDTASHRSGAASEAQVKPSNSGQGYRIPPSLPPMVANWCRCALSLDHSQPPMVLEALRDTLTTIQASLPDRILHSHVTTGEGAAARERGADDGDGSTYQEMQSHICGEMFDVLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSX8</accession>
    <name>A0A088RSX8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Exonuclease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_251470</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the exonuclease superfamily. TREX family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699717.1">
        <property type="nucleotide sequence ID" value="XM_010701415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSX8"/>
    <dbReference type="GeneID" id="22575795"/>
    <dbReference type="KEGG" id="lpan:LPMP_251470"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250020400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_251470"/>
    <dbReference type="eggNOG" id="ENOG502RS5F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250935at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06127">
        <property type="entry name" value="DEDDh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000168">
        <property type="entry name" value="Exonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040393">
        <property type="entry name" value="TREX1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13058:SF19">
        <property type="entry name" value="LD40940P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13058">
        <property type="entry name" value="THREE PRIME REPAIR EXONUCLEASE 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="9">
        <location>
            <begin position="89"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="336"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="440"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN99010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="499" mass="54885" checksum="1CB1C2B1657207BF" modified="2014-11-26" version="1">MLRQSYVTLRRKASVVLKGQLNPLEALTQIQLGITPSLPLQRGFLLEHCEQHLEKLGITEGKLLAMDGRLCTQLTKRIVYELYLSVPFRVFTFDMEFTGPPVFTADGPTEDITELGLYSPLLDEVFSCLVQPVCGRKQGPGVEELTHITDAMLAKEGIPFLEAWQRFLKFVQTPQPNEIPGSEERILLLSHGGKLADVSLIKWTLEKFHMELPSSFVFGDTIHLIRDAHRRRPVTVDKHPPSWKLVDLVQWLHISPTLSAHRAGNDARMTWDALYHTLLRYGDDEMTPREQLVPRFFDAEAKQRLREYTTRQAQEKDSLGLDGTFLLADAPHCASARHSEHSDTGNFAHRSGSYDSGNSGKSGATTDLLDLDFDDIFSGQNKVGASPPIEEFKVDDNEDLDSSANGASDLTASQTLLSRAASCPAAFSTDAAEGDVGDVNTASASALPPNQAAKTATSDRRKVKVSDSLRSKGGAEKRNKLRGSASDPPAAATAAIFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RT77</accession>
    <name>A0A088RT77_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Inosine/uridine-preferring nucleoside hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_260340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699855.1">
        <property type="nucleotide sequence ID" value="XM_010701553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RT77"/>
    <dbReference type="GeneID" id="22575937"/>
    <dbReference type="KEGG" id="lpan:LPMP_260340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260008200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_260340"/>
    <dbReference type="eggNOG" id="ENOG502S1Q0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5783963at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008477">
        <property type="term" value="F:purine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006152">
        <property type="term" value="P:purine nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="INOSINE-URIDINE PREFERRING NUCLEOSIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304:SF4">
        <property type="entry name" value="URIDINE NUCLEOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="5">
        <location>
            <begin position="142"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN99148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="342" mass="37179" checksum="51301B7C0B136F79" modified="2014-11-26" version="1">MDQLKEYYQRWNDVPQPGKISILKRIALACYFLFLLLLVIYAFGRTAKTTSAIVPIVLFTDGTPYNMEVIRYLAQRRDIIIGMIVLNNNSLAVERLRSKTGNVEAILSALKAEGYTKAVPVYASHMSSPDNFAAPLDQMVAKRLVKFIIAGPCTEAAYFLAAYSTHRSNIVDIFVAGGAFNKAGNANVLLPTNTKAERNFYMDPSAADHILAGSHGRQVTLFPIDVAIAWTEEAYAAIVSNLSSTAASVGIVASGLQWYYTNIDPSSSTTVGLMAAVYASDAQVRETATYTSIPVRVRTGGTNITDGQSYRPASGALVRVMLSVAADTFFSHLLRVDKLPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTB7</accession>
    <name>A0A088RTB7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Dynein heavy chain, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LPMP_261000</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699920.1">
        <property type="nucleotide sequence ID" value="XM_010701618.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22576003"/>
    <dbReference type="KEGG" id="lpan:LPMP_261000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260014900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_261000"/>
    <dbReference type="eggNOG" id="KOG3595">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5593012at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000005">
        <property type="entry name" value="Dynein axonemal heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000013">
        <property type="entry name" value="Dynein Heavy Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002141">
        <property type="entry name" value="Dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000007">
        <property type="entry name" value="Dynein heavy chain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000063">
        <property type="entry name" value="dynein heavy chain 6, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000010">
        <property type="entry name" value="Dynein heavy chain family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.130:FF:000025">
        <property type="entry name" value="Dynein heavy chain, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000362">
        <property type="entry name" value="Dynein, axonemal, heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001401">
        <property type="entry name" value="Dynein, axonemal, heavy chain 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000013">
        <property type="entry name" value="Putative dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001145">
        <property type="entry name" value="Putative dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041589">
        <property type="entry name" value="DNAH3_AAA_lid_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF68">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17857">
        <property type="entry name" value="AAA_lid_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="1298"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="1579"/>
            <end position="1725"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="2005"/>
            <end position="2225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="2822"/>
            <end position="2891"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="3177"/>
            <end position="3207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AIN99213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="4043" mass="457556" checksum="7C154C1E1C225DA1" modified="2014-11-26" version="1">MRTTADTTAAASASDDKDMELLRMIQKASRRPTRAREKRAAPNDEPLLRNIHTSEEAVAFFTVNGNSTSLKYVFLNCAPKGLDFRPYDLVATKKGSEEPEHYILSTTGIVHVQPGRFSEVMTLSEWMKESSLFNILRKIPFFKNFVLYKAFLRLQMKVAQRKYAATRRSLQKDLLVAKTTFACPMLDLVKYSHTISDTKLIEYDPQGKHDYVVDDYSLGQSIQRQKASVFVNGIMEHIEEKVTKLVEALKHRADVPDINTREALQQYLLIVAAGEVSDTRVKRKKKSMIEAREDLERRMRELKRSLVEYSKLHVFIRLIDLVVSEQLFQRVLSVLQTFLNLVRGQAQSEVRKVGFQVLLRPEESAVILDPKESVLRALFAELLSGCTDTATIGPRLCEQKHLKALFPSPPKVWNIGDELRSSARVVWINTALLSILHSDYEKAGGRLVTYLATVPHIQFLRKSWDEISVEYKQEANEVVLSATSLAKLYHRLQEAQDSLRVLIATYVGCLLWVNAAKLKTEIEPRMTILRDAINACLRNTAHDMIRELNAYFKSKTQVMNERPQALREFADYIAVFKEIAESTNETDMKVAQAEALCELMDRQQVDFSDDEDKQLRERTLSGSSTTKSLHSLFDEARICAEEFIEESMPAHVDTLQLEVANVNEECSGLNEILLGEEFALVTDHTEPLLQYLADINAKLAEVDLREGQLSRSAKLFNLQPFDWTFVSDVKTLYQAREEIWSMLDSFNKKSEYWFETPVKELDTTDMEEQVTLLIRRAGAVNRTMLERNYEDEVAPHLLAELQSIRANMPVIHDCGNKHMTSEHWNAVLKRVTGTAYSYHDDLNLNSLEEWDIFSFKEALAEQSGLATGEWKISNDLDVIRQSWDALNFMTKPYKSCDSVFILDGLEEVIQQLDDHQIELQTTMASRFVAPVRAKVEKWLLDLRVVGNVIEEWITLQKNWMYLEFIFSSDDIKEQLPEESTLFDSVDRFFRSLTSKAHNQKNVLRICIEDGVLEDLQRCNANIDVIQKKLEDYLETKRIAFPRFYFLSNDELLSILSDVRNPKAVQPHLSKCFDSIASLLFSDEECTEIVGMVSGEGEQVPFEAPVYPIGNVEQWLSDIERMMKASLLSHMHSTIEMVSQHKREEWMFQHPAQCIQAVDMIIWTGQVEAAIERAALQSFYKDYHDQILRMVELTRQPLSKMQRMLVGTLIVLNVHNRDIVHNLSGEGVTAVEDFAWYQQLRYYWESDARQAQSGGKNVEIRHCNAHLWYGYEYLGNQPRLVITPLTDRAFLTCTNALAMNLGAAPQGPAGTGKTESVKDLGKALARQVVVFNCSDGIHYKTMSRMFAGLAQAGAWACFDEFNRIELEVLSVIAQQMLDIVLALGQKLERMDFDGHPIRLSSNFGVFVTMNPGYAGRTELPDNLKALFRPICMMIPDYALIAEIMFYSEGFANAQCLAQKMVQLYKLSSEQLSKQDHYDFGMRAVKSILVMAGSLKRQSPSESEDMLLIRAMRDANVPKFLREDTTLFMALVKDLFPAIVVEENPNTLLLSYIHRQLTADGRQVVDGLVTKAMQLYDTLVVRHGVMLVGQTFTGKSTVLHTVQQALTHIKQDGHDAEGNVSLFNPVHVHLLNPKSVTMGELYGQVNAITREWTDGILSNIARGITQAALTKPDRQWIVFDGPVDAVWIENMNTVLDDNKLLCLFNGERIKLPATATFMFEVQDLRVASPATVSRCGMVYMEPYYLDGNRGWVPITRSLIEAKAKVDTRLHADRLLELLDTLLPDTLDFVRANCREWIPSIDAQLAVNCVELLQGFLATSEDAAVWPREAITPAETLDADCDDGSGAPHEDTDLYAATNRSSLLAVAMPIPSTPAEFTRLAITSATAATPDEHRLFDMYFLMAFVWAIGGNLRDDARDIFSAFLHDKVEAVLPGLLPLSSDAAAESEEARQKVSLYDYVVHRPSMQFITWSHLVPTFLYNPRSSYFDLVVPTAEGVAFRTLLGVLTASSQHVLVNGVTGTGKSLGITTFLASALHTDDPASVWESFSIVFSAQTRSKDIENRLENKLHKIRSTALGPTPGKRAILFVDDINMPTPEIYGASPPLELLRQLISQGGFYDTHKSPAFFKELHNVLLLAACGVPGGGRSEMTQRLTSRFHLICQPALSESSTRRIFGSLLHGFLHQWDSDEIRTLSTKLVAATLACYERITQEKLPTPTRSHYTFNLRDIGKVIQGIMQTSPRVTSSPEAFYRLFLHEVSRTYHDRLVDASDRAWWWSMLSAVSKSVLQHPWNPIYEELLFGDFMRRDRAHYEEITDTTDAIARGLTEYQSGLNTEYNKEVELVFFKDAVQHVARLCRVLRQPRGHALVVGMGGSGRQSLCKLAAFICNLPIYEVTITRTFNMNEFHDVLKKVLLDSARHDKPVLFFLSDTQLVHEEMLEDINNLLNTGEVPNLMESEDVDQIVEAVRPYAIAAGKRETRNTIFSHFASMCRDQVHIVMAMSPVGEQFRRRLRMFPSLVNCCTIDWFDQWPCDALASVANRVLANLSMEERDKERLIELCAAIHVDVQEASELFYSELQRRTYTTPTSYLGLLTSYRQLLEEQDKSVTAQVERYQGGLDTLLSTRTMVDAMKVKLIEMHPKLVEAAKNTEEIMGRVEREQESAEVVRKQCAEEEEGASEIQAEADGIRGECQVELDKAMPILKAAEDALADLRPDDIREVRSFLKPAVRVVLVLEAVLVLLGEKDLSWDRAKLVMSRMDFIKDLQNYKRDDISEKTIKSIQKYIKNPDFQPEEVAKSSKACKSLSMWVMAMNNYYEVVKVVAPKRARLAEAEAKVAVATQALEAARGRLRSIEDKLTALQAEMKENVLKKHRLEEDIELTTVRLERAEQLMNGLTSEQSRWLEAVAKLVAEKQGHPGTVALAAGAVTYLGPFTAPYRDRLLRAWHAKCVELGLPVGGSGFQLSSIMDPVFIRGWAQRGLPMDSFSVENGVVVTKSRRWCLCIDPQGQAVSWIRAMEKENNLRVVKLTDVNYMRTLENAIRVGLPVLIENVGESLDAVLDPVLLQQTYRSQGRLLIKLGDSEVDYDPKFRLYMTTKLSNPFFLPELQIKVTIVNFTVTQTGLENQLLADVVRVEMAELEQRADQTVLDIANGKSEVKALESKILKLLASSTGNILDNEQLVSTLQEAKATSESVSDALRVAEETQRDIETARDRYRPVARRGATVYAVITELSGLNHMYQNSLDFFKQLFVLTLRQTEKQDSVDQRVATLLPAVTLRSYNAICRGLFEADKLIFAALLYVHVARQESTIADEEWSFLLKGSEGKRFVDEEMDPPPVWLTLSVWNELTALTETLPAFASLKDSVIDNETEWSEWYAGEKAYEAYPASLGSYSAWQRLLILKVLREDLLNYGLSQLIERELGRAFTESPAFDLEGCYQDSTPMAPVIFVLTPGTDPTQLFTEFADRKGFGARKMMLSLGQDQGRKAEEMIRVASTETGAWVYLQNCHVYTSWMPSLERILEELTHREVQRDFRLWLTTMPVASFPVLLLQSGVKVVKEPPQGLKANMRDAFAVAVTQDLWDSCPRNPTTWRRILLSLTFFHAVIQERRRFGPLGWNIPYEWNQPDLSASLQSLQTYLKDEDEAVPWSALRYMVGVINYGGRVTDFLDSRCLATILGKFFNDDVVEPNTQFDFSSDGVYHIPEDVSSLASVRAYLNSLPTFENPQLFGLHANADIDFNKSTVRRQLAAILSMQPRTKAAAGRSPENKVLEMVEEFQRRLPTAIDKAHAHADTYRLTEAGAMISLGTVASQEILFFNGVLAKLERTLRLLLRAIKGEVIMSADLESMFNAMLLGQVPKLWHDGSYLSRKPLASWYEDTLRRIKFFRDWNNNGLPTSFWISGFFFPQGFLTGVLQTYSRLHQTPIDEVKFCTHVTCYELPEDVEDSKESGVYIHGIFVDGAGFSLDSSTLEESKPGELYKPMPVIHLEPVRLSEATATSESYACPLYKTSARVGTLSTTGLSTNYVVTLDLKSAAGVRPEHWIERGVALLCMLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTI6</accession>
    <name>A0A088RTI6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_262010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700020.1">
        <property type="nucleotide sequence ID" value="XM_010701718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTI6"/>
    <dbReference type="GeneID" id="22576104"/>
    <dbReference type="KEGG" id="lpan:LPMP_262010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260024800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_262010"/>
    <dbReference type="eggNOG" id="ENOG502SM2W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266588at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="656"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="666"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="897" mass="95744" checksum="5845261854E1654D" modified="2014-11-26" version="1">MESALQNVERGIRDALQRLSDARARLATHRAALDEGRLMLASAVSPLLQLYPAEPVSLIPSCSSRGAKGTLVQLLSGHSAKSVISANNSPRHNALHCVDNPAEDAEEAIIISPTTASSAAASVAAAAGGRVSAPPPLPSLQLPPLMPSVLALPRTSMCAGFYSAMVARMQQLEEQRFNYRSKHVMHAAKLQIAQTWAREVQPWFDTVVQRGFFQQVIRRLDALDRRVARLCGRLALDRPQYVLTHHCTIQLKKDGGAPDPMVGKEGHLRRRQPYPQWCLDLTGDELSRGQSDLLCGANEQVLSGSDGGGERQAVQRCCFTEEVTCLSGPPSQQGRPCGATVGFGSAEGNHPSMCSLWRQYVQMASQTPGLGDEQRQTCEQSYSTPLPAEVLPEPLLRTPRSLRHVWHVIMEGLTSSGVDVVNNSVSAEPPHVLFASDGVYVGDAMRKSGNQLCQSDPSGVFLQNLSDLVRRCSALHPPPSAAQSTLPLCSHAEHRHETEYHGGRNDFAGDGRCGATALTQAPLPQDTDSPTVGLLSSHVCVLLCCAMQLCALAKLCNGICAGKPVRYKTPLPQLAYDGDVGGCSEDDAIEDGGIGDVEVARRGPRRSITVLAGTTDGLSMCQHTCEEQIAEALAAVYHAVPCLLSQFGLVFQKRNSSHEDDSDGWQGRRSEVKAAEVDESTGPQLCVASAGEGRICLMSNSADAGAAADGATDAVLWPTVGDALRDRDTFVQWWLSLASLSFNTELPQSGTPLVDLSLVYARALRVGCLFHSLLDSVEDACGERLPLPAAEAVPAVPSPGTPTLLTVARADSSTLAIRGTHVAHLNTIAAHRAAANVSASVPPLAASAQLSSLRQIELQMRQEWQSIETRLSVARSMAAATLRQAAHNDNEAGDLAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTT0</accession>
    <name>A0A088RTT0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_270470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700135.1">
        <property type="nucleotide sequence ID" value="XM_010701833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTT0"/>
    <dbReference type="GeneID" id="22576223"/>
    <dbReference type="KEGG" id="lpan:LPMP_270470"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270011200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_270470"/>
    <dbReference type="eggNOG" id="ENOG502RYHX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272525at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="599" mass="65316" checksum="8D1102F804C587F9" modified="2014-11-26" version="1">MPIAASPFMATRTGTCAVLEMRHRTVIVAIEAELRDSLTSAADGESTSYVLWALTIPMRVACFADGLYTKTSPVPLAFASVVSGTPRRRAVVSLPRWDLSGGTRSALLLAPLDVPSVLVQEALEEALGVRRAAAQSSPSLKRVPVVRWRLSGTEAISLDLLAEVEWQPLLHRRWYELKSYVRQGTVVPYYSAKAGCRSANGTHIHRSSADSFHSAPPVSTGVMFAGDVKEADAVSVNRACVMWTDGMVGLFDEVKPYYRVYEPARLEKTIRVRRFPHRYADVVGEVPFGKRIEAFGRATDPFTAEEYVLVYLPTEEAFAAHVSTYNLIYMGEGRYIWGWSKLAGTSDLPLLVEAEGNDASAGDTPAGLGNDHAIGSTTCSARSSVQEGGRSDVMLLPEPTFYTPVRDGRPVRIRSKPLLSSTVLREMETNEVRTAVALVTVPLCLPADPTGMLVNHVFVEWQQGGYSLLCNATESFLAPVQLSRVPRRLSIRTCSNGEKGMAAVPEVLDLCRQRSPKRGRDSTASENTNEEATLAELISPHRASARVASDASLRSLHSLPESLQGSLKKGEMRPEDLLAIEEAREGRESDNSGDGSGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTW7</accession>
    <name>A0A088RTW7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_262480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700067.1">
        <property type="nucleotide sequence ID" value="XM_010701765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTW7"/>
    <dbReference type="GeneID" id="22576151"/>
    <dbReference type="KEGG" id="lpan:LPMP_262480"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260029500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_262480"/>
    <dbReference type="eggNOG" id="ENOG502S2UP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="13601at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="143" mass="16531" checksum="3E9F6E37592BB3C7" modified="2014-11-26" version="1">MSATREDSAPCAIPSKLWRECLKQYDYGPDRPKGACAAHRTKFYDCVKDWTARTQKRPYSYTLFELPKSCGHEAEKLHQCMMMNMFEVSHCQKEMAVLKRCAARADPEVRTYLQGDEAIADLEKDIEETTGLKRLWYKAIGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RV24</accession>
    <name>A0A088RV24_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pumillio protein 8, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">PUF8</name>
        <name evidence="3" type="ORF">LPMP_252460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699816.1">
        <property type="nucleotide sequence ID" value="XM_010701514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RV24"/>
    <dbReference type="GeneID" id="22575894"/>
    <dbReference type="KEGG" id="lpan:LPMP_252460"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250026700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_252460"/>
    <dbReference type="eggNOG" id="KOG2050">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="497380at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001266">
        <property type="entry name" value="Pumilio/PUF RNA binding protein 8, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040059">
        <property type="entry name" value="PUM3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389:SF0">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUM-HD" evidence="2">
        <location>
            <begin position="70"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="577" mass="65266" checksum="83F41E3B51A0DBE7" modified="2014-11-26" version="1">MGRTNTKKQKAREERLSKLPHSERLAKSALIKKKEGRVLDAAEKHSLKMSSEHGEVLRLWEKLRTIEERTVQQAAVSANKKIAYEHKYPMVDKLIHFLEPKFASLVRTPSVSRVAQSMIKYGSGEQVGTVLKWISKDFSTYATDAYAHFVVCALVRHVPHEAYSKLVTHVIPSVPQLVAHKFGIEVLHSVYSSRWCSPADRSLLLLAVFKDSVAVMKRWPGYPEIEEVLKQNPSLQRRLLTRLFDLCDKLVSLKEAIGYPFVQRLVGTYIRCGTREEVSELCDTLRPHIAAISVTREGAPLASLAFSLTEPKKRKEVLHNFNAQLGELSTSKYAAPVIARLFDLLYDAQMLKKYVASDLAEHIGQVVNSPYGYQILMHLLTPHEERKRKFLLPHWQAHNLFSMENKEWNHHTWLTSAFVPETVEICSKPAVTSHIAALPMLVKAFLRYATDSANDAKLNRHHAALIAREILHVVQNEPLYKTAIQLSADEEQELFKMAPAHGKREREDATEEEEECAIASAKYSRHENSRQKVAALTSTDLKKKMKAPGVTSVTAAPKGRRVKKDAKKNTKIQTSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVQ1</accession>
    <name>A0A088RVQ1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA polymerase-associated protein CTR9, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_292560</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700860.1">
        <property type="nucleotide sequence ID" value="XM_010702558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVQ1"/>
    <dbReference type="GeneID" id="22577019"/>
    <dbReference type="KEGG" id="lpan:LPMP_292560"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290028000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_292560"/>
    <dbReference type="eggNOG" id="ENOG502SS96">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="343875at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031101">
        <property type="entry name" value="Ctr9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14027">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN CTR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14027:SF2">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN CTR9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="854"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="793"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO00203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="873" mass="96824" checksum="93053677795D207E" modified="2014-11-26" version="1">MAAAATTTSTTTTRALDEFHSGNVEAAQFILEEAAKSEHNVNELLSIHCLRATLAAMKGSMDVTSITAQLAPGEPVRLPVQSYLEGVAAMARGDLATARRRLETAVERCEGFGAALVCLAAVYYLTSQYEKSYAQYCYTLKMFGSDEAPSVVRVGMGLCAFRLQRLVDARRILERAIEVHPDDELAWLGLLAVYIDLRMLPQIHTAVVRLKHLMPQNTTVLLKVCDLAYFRSLEAGRLKSSMVRLRSLLRYVRQRASPEEMALVDFHEGRLLLVCGEVAAAQPLLESAVRANPNLLAARIHYARLLMYANRHADAETLLMEVNRTWPNEKEVLQMLAILATRAGRHSEALRYSHTLTMTVAQGDVNSWALAAVCSRLDTEHCKRICAHVRAVQRELNLPSSWKLSANLAILSGDVEAMQGIVDTELGAAFLMSNIAVDISYVPLLYNLALLLEKREPARARQLYVYLVKHCSTFAAPYYRLHFLAKEAGQLQQAVAWLQWLLKVHPMEATAQTCMAQLYMERSNVKEALAIFKKVNASELQLPVALAVGSTSLQACQQSSSQWPKLLASARSFYRDVLAKDPRNILAAHGYACCDGLERRGDAAEAMLNSVSEVTSLSTVSTSNVDAHRANVKMLSHGYKQAADYFARMPTRTSEQDAMYSFCMATEGRYTEALELMHTATLKAPSGDPMLVYNTALLHFMAFVDGLKGTRALTAAQGEALLAHLESGRRGATLLESIKGKYELMSRAKRYLRSISAYCERHCATVHALVEAGQQRAKELALSEEGWRRVFASHKAEQQRRQEEEELAEHHKAEERKLAEADVYARFRLSRIQQPAALLNADLLAATLADAMQDTMPEEGQSMALGEEEGELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVW2</accession>
    <name>A0A088RVW2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aspartate--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Aspartyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LPMP_300480</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="3"/>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701083.1">
        <property type="nucleotide sequence ID" value="XM_010702781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVW2"/>
    <dbReference type="GeneID" id="22577102"/>
    <dbReference type="KEGG" id="lpan:LPMP_300480"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300010100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_300480"/>
    <dbReference type="eggNOG" id="KOG0556">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="372395at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04320">
        <property type="entry name" value="AspRS_cyto_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF1">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="213"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIO00283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="550" mass="62564" checksum="4C7D0375EFAC659E" modified="2014-11-26" version="1">MSSNHAEAKAPAVEKKISDKEARKAARLAEEKARAEEKAALVEKYKDMFGAAPMVQSTAYMSHTYVPVADLSQPALVDKTVLIRARVSTTRKKGKMAFMVLRDGRDSVQAMVAVEGDVPKEMIDFVGQIPTESIVDVEASVCKVEQSITSTSHSDIELKVKKIHTVTESLRTLPFTLEDANRKESDEGAKVNFDTRLNSRWMDLRTPASGAIFRLQSRVCQYFRQFLIDSDFCEIHSPKIINAPSEGGANVFKLEYFNRFAYLAQSPQLYKQMVLQGDVPRVFEVGPVFRSENSNTHRHLTEFVGLDVEMRINEHYYEVLDLAESLFNYMFEHLATHTKELKDVCQQYPFEPLVWKVTPETMKELGVGVISKGVEPTDKYQARVHNMDNRMLRMNYMHCIELLNTVLEEKMAPTDDINTTNEKLLGKLVKERYGTDFFISDRFPSSARPFYTMECKDDARFTNSYDMFIRGEEISSGAQRIHDPDLLLARAKMLNVDLTPIKEYVDSFRLGAWPHGGFGVGLERVVMLYLGLGNVRLASLFPRDPQRTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWG4</accession>
    <name>A0A088RWG4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Vacuolar assembly protein vps41, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_301340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701164.1">
        <property type="nucleotide sequence ID" value="XM_010702862.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22577188"/>
    <dbReference type="KEGG" id="lpan:LPMP_301340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300018400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_301340"/>
    <dbReference type="eggNOG" id="KOG2066">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="244107at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057780">
        <property type="entry name" value="Beta-prop_Vps41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 41 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23411">
        <property type="entry name" value="Beta-prop_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23556">
        <property type="entry name" value="TPR_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps41 beta-propeller" evidence="5">
        <location>
            <begin position="162"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="3">
        <location>
            <begin position="976"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="769"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1182"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="771"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="790"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="810"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="826"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="841"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO00364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1451" mass="158071" checksum="9CA4F03A6DF63566" modified="2014-11-26" version="1">MQRPGSSGGTSVSSSFPSPSPVSVRDADHTHDGKVASASLRRRDDGSRASSSSARASHHTLEKGEGAGRRVTRHSSPGGSDKADGDGIDSTEDPSYTSYYEYNSDYDEEDADCFDSDSYRDSGNVDGYRSSTTGSLPPQEDLLRFLSYTLDEAALKDHRLMAIEAFRHILVLGTNQGTVAVIDSSSGKVKEVYTNHHEPICDVDCTVNELYIAACDKAGYVTIQSRRDVKDVWMAELSGPINSVALHPLYHKMDSCPMLCAGATKVHLLTKGLLWSNSRRVTTLQEGRGRIHKVRWCHATAIDVAAWLSDAELTLYDIKNQAVVRRVPLPGLSAQNALYPPTLRWEYNLSRDPTAAASPTAALLSGWGDVVQEVQLYAGLPVCRQSGGGIFSAGGSPRSTMSQDGCLNASSSLSLLREASDSPALAPSRPSTTAADATGRGPYVVELRTPQPLRPSSTLFPYRVCGIAPYGPQRYVVLACIIEHGMEGVMKDLEVRVVDRGSLADIYRGRMPIRFIHPLQLHLTYLELLPSLAARSASPASLRQLALPPDPLAPSPMTQYFILSVDTIVKAIPSDIDDHVEFLLRTGQFERAYRYAVAYARQLRRHVLEHVGQQWLMHLFHNRNTEDGALRKIVELLPELIPRDSSAAWEQWIYRLDTCGESWRLVALLPASTGASAEYRVGSTSDVEEVEDTHVEHAVAMTRSLLPPVATLQTPIQREYYDLVLLRCLRHDPRLFYAALHKFNTLFSVPVVLKATEVAHREQCATAAWWEDNDSDEEEGETEGEHGQTRRVTVSDASPTLSAANADESGVQSVSPASSLPTTPQGTSAETSTTGAAPHPSQVTMSGAGATSTPSMSRTSRWSLAASYGFLLRCAGRHEEALQVLLRLPASPRSDREVFGLIRDQQLFHKARELLPELLHRREGATLQLLMEHVAGSTAGSGVANGAGEAVATSPAFVAPSGGAPPSSLSSTALQYGSAQDPLCAESVISRLEHSDRLHLLRYLNLVQQLYPEVFAHTAKQHAQLLATLYIDYDRSSLLPFLKQMSMYIERIRELHALCHKHHFLEEEIFLLFRMGCEDEALRILVEKMHDLPRALRFVVSVPDLEEQAALFTRLVDYTVAYNASLPTCNLDSTKGATGGFGVRVRYVIHHTKPNETYASIAQKYHVALGDLCQVNGVSRASGGVESSKRRKSSSTSVQGEGEGQRHAPCDTDAAENSPVPPPQCIVPLNLFGNLFETLAESQFMEYPALDVRHVLRKLPSREPILHAGPSIAAIAHAMEEEVAFFSTVSKVGEKDLMGYYGQLLKRRTAAIAMGQRRDLAVSGASTSTGAATTVMHVADELSEVSGVAHRCAACCQLVIQRVVVFACQHIYHPHCVLQYLKKSPPDAFTGGGGVGFGVHAGDAVAVMHDDASIALPMTSSAAAGAETTEEQLRKLPVYCRACRQHSGGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWL9</accession>
    <name>A0A088RWL9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA ligase</fullName>
            <ecNumber evidence="14">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LPMP_303410</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="14"/>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701363.1">
        <property type="nucleotide sequence ID" value="XM_010703061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWL9"/>
    <dbReference type="GeneID" id="22577394"/>
    <dbReference type="KEGG" id="lpan:LPMP_303410"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300039000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_303410"/>
    <dbReference type="eggNOG" id="KOG0967">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="206088at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07900">
        <property type="entry name" value="Adenylation_DNA_ligase_I_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07969">
        <property type="entry name" value="OBF_DNA_ligase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3260.10:FF:000013">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000062">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000002">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF4">
        <property type="entry name" value="DNA LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00333">
        <property type="entry name" value="DNA_LIGASE_A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 14 18" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="17">
        <location>
            <begin position="503"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="16"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AIO00563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="776" mass="85873" checksum="B7EA0FA35F0C735B" modified="2014-11-26" version="1">MHQTTLDRLFVPVASVGGSNEADNSRKATKKVTTASNREDRKRPREEEKVASQCVSSTPTSDTATGRRTRWNEPTNAYYAQHVAEYKALIANVPPPTATSMAKLFQESTFDPVTTFESVWLPPRAPAALPTAGALEPVPFAAVVDVLADISATGSRLECLKQLTFLLLAVIERCPEDLVPVMYLVINKHAPQHEGVELGIGDAVLVKAVAECCGMTESRTKEEYRQSGDLAEIAQMHKQKQSTLMKPKALSARSVFKSYREIAMMSGKDVVRRRSDLIKGLLRDAQGPEVNLIVRGLQQKMRIGLAEPSALAAVGYAFALHFVGSAQMHTMSEVQLQTLLNSGADSLARIFYEVPSLDVVLSAVLASGFMILVPGSCIAKVHAKELSIRPGLPVKPQLAHPTSGITVILDRLQGKKFTSEYKYDGERAQIHYSKDNGFHIFSRNSETHTGKYPDVIAILPNTFDAAEVQSFIIDAEVVAVHPETGALQAFQVLQHRGRKNIAEKDVSISVCLFVFDLLYLNGEPQLNKTLQQRRELLWRYIRPLPAKLCFAAYLDSDDVEDVQKFLEKSIADGCEGLMVKTLEEEATYTPAKRSHYWLKLKKDYMDGVTDTLDLVPIAAFYGKGKRTGVFGGFLLACYDPKADEYQSICKIGTGFQDEELEKLTQSLKPFVVHDKPRYYRAGGEEPDVWLTEAQVWEVKAADLSVSPVHQAAVGLVDPNKGIALRFPRYVRQREDKNPVDATNTQQVAEMYKAQSLAVQHDASGDAEWAVTRTETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWX8</accession>
    <name>A0A088RWX8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Calpain-like cysteine peptidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_310440</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701433.1">
        <property type="nucleotide sequence ID" value="XM_010703131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWX8"/>
    <dbReference type="GeneID" id="22577470"/>
    <dbReference type="KEGG" id="lpan:LPMP_310440"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310009200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_310440"/>
    <dbReference type="eggNOG" id="KOG0045">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268518at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015232">
        <property type="entry name" value="DUF1935"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036310">
        <property type="entry name" value="Smp-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF423">
        <property type="entry name" value="LEUCINE-RICH REPEAT PROTEIN (LRRP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09149">
        <property type="entry name" value="DUF1935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101601">
        <property type="entry name" value="Smp-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="4">
        <location>
            <begin position="182"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="active site" evidence="2 3">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="active site" evidence="2 3">
        <location>
            <position position="430"/>
        </location>
    </feature>
    <feature type="active site" evidence="2 3">
        <location>
            <position position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO00633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="714" mass="81500" checksum="17CE74F9E05863D1" modified="2014-11-26" version="1">MRFRRPGWLCGGSSTKSKARKRYLQTKVHKFKYGGPAVKGDCYPLFEDGRCYRVEVDKRKWFLYNDTLDMEMHIIFTFHKTTAVYKTAHGRTKVRTTPAGGTECTVVVYPLETLPYVKFAEKTQIMYSATRTSRGLDPNYIERINREAKAKCLSETQKVAGVAGVSHDEEELLYRCRKSNIPYVDMSFHPSQASLQRPHDKNSVANMTSITWRRPKDYIPAMAHKEIKLFRHGVDADDIEQGHLGDCWLMCSIAVVAESKTMVKDIFRHPVSRSKRLKEEQAGGYRVYLNKNGWFCNVIVDSYLPTYNGVVYFARSAGDPYELWVSLLEKAYAKIHGSYASIIGGNPLHALQDLTGFPVYAFTKTWRAAANEEEVASQFFKDLLRYRKSGYLISISTPGKDTSAYNVDSRTSNEASLEARYKAVGLNTGHSYSVLKVRQFLIPRVKLLKIRNPWGTGDEWTGAWGKNSDKWQKHLLVRRSCKPSKVSDGTFWMEWRDAVQFFEGGGVCMVKKSWFQYRFPGSFVGIIPSVVLRIELKKRQKVFFTLSQKDRRLRSPGDPEELYKGLLICVTGHNAEKDTQQIVALSTENPEVHPPDRYEYIIARDVGLELELDPAQSPLYVIPRIMVANRNGPKDFTLSMLTPNKSTASGLRVSFVRLPDTCPTFRNVVSFKMVGEKAEHVQFQYKKRGGTPRMKSGITVFEATNVKEKYPFPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RY49</accession>
    <name>A0A088RY49_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MIZ/SP-RING zinc finger-containing protein, putative</fullName>
            <ecNumber evidence="7">6.3.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_292530</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.2.-" evidence="7"/>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700857.1">
        <property type="nucleotide sequence ID" value="XM_010702555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RY49"/>
    <dbReference type="GeneID" id="22577016"/>
    <dbReference type="KEGG" id="lpan:LPMP_292530"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290027600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_292530"/>
    <dbReference type="eggNOG" id="KOG2169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28127at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF96">
        <property type="entry name" value="SP-RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="6">
        <location>
            <begin position="231"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="357"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO00200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="405" mass="44016" checksum="26EAEF4B6EF07363" modified="2014-11-26" version="1">MSANTRAHVDHAHDVLRGIRRVRTTVQLQEAYDGLLAFLKTTRQQVETQAANSAAPGIKGSGGSSKVYLQVPSNPLTEAQAAMSQLRQVSLLCGAFCRRVEHLLRTTYTYADVDDATHHGLATVHVSTYMTQLTEELQRFNTPAVNRFLAAASETSVASTSPWPVSPVDCVLSYGIGDLFDYRLCRRKRAQTYLQYLLAQPQWSAAAITQVIVSLNETLSTPADPFSVCTGDEGVEATLFVTPLRDPISQTVIQIPARGETCVHLELFDVESFVQATQQRSFSTMDVGAPCPLCSRTVHLSSIRVDTQALEAMRSYERAAAATAVSSTSSAAPSPLTAECALEWNTDTRTVRVVRGGRGASTEASAVDEDQEEPATPLQGARDDAPEVVMKRRRIEIGGHVLYAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYR0</accession>
    <name>A0A088RYR0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_321910</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701876.1">
        <property type="nucleotide sequence ID" value="XM_010703574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYR0"/>
    <dbReference type="GeneID" id="22577932"/>
    <dbReference type="KEGG" id="lpan:LPMP_321910"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320024700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_321910"/>
    <dbReference type="eggNOG" id="KOG0589">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001511">
        <property type="entry name" value="Serine/threonine-protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000698">
        <property type="entry name" value="Serine/threonine-protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001105">
        <property type="entry name" value="Serine/threonine-protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="144"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="537"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIO01076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="655" mass="70915" checksum="93ED92DD9B5828D2" modified="2014-11-26" version="1">MGSGLAKSCSNIPGESAADEGNAYSLAKSDLKVGTVAAALATKPSAAGSAQWTCNPHASNRGDIAALVATTTVAPPKNNKVELCAASITTGSPPKGSRSKGDTSSVTSVNDAGSPIPICNGRGERVGYLSLSDIIGGKDSHSKYVKLQSIGRGAYGEAYVVMRNPAYNPAALPMVEAQSNSNVLAHPTQPNGLYVAKIMDLRAMMSQDRQYSQREIMCLAHTNHFAIIRYYEHYVLDSDDEAMIIITELADRGDLRRSLYNASTVRPFLEEGSNAAASNDAGTNGSRILLSEREAGTYFVQLLLALHHISARRMIHRDIKSANVLITSRGFLKLGDFGFSQKYESTVSSENIAGTFLGTPYYLSPEMWKGRRYGKKADVWAAGVVLYEMLMGGHRPYEAGSLPELRMHVLEDEFVPPTGPPTLGTADAHSQEAGKAKFSNDMRELLASIFQKSPEKRPSAEELLHTSVMQHYLFVFEKYVQSLISADAAALAANPAIDRQKLYFPDPADQALVLQGIAEGKDVVAQVSRRTISESAAPRYEGVVFKDNQNGVWKERYLVLDGSVLTISLSKGKEAVSGGERSKRVPLSFIKSVSPCEVEDAHVRVGTAGCPTNSYRPPYAFAIAMRSTNSIVFGVPTAEELDQWMQVLMRALQID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYT2</accession>
    <name>A0A088RYT2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3456 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_322120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701896.1">
        <property type="nucleotide sequence ID" value="XM_010703594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYT2"/>
    <dbReference type="GeneID" id="22577953"/>
    <dbReference type="KEGG" id="lpan:LPMP_322120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320026800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_322120"/>
    <dbReference type="eggNOG" id="ENOG502S9EW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="249838at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021852">
        <property type="entry name" value="DUF3456"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11938">
        <property type="entry name" value="DUF3456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3456" evidence="2">
        <location>
            <begin position="60"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="370" mass="40902" checksum="A62E77AF0D8F7C4C" modified="2014-11-26" version="1">MRAPSTPLLAPLQRNQRHFLLAVIALLVNLFLASSLTLAATPAQGKSIRPLHGAGYEHLDCSACITVARTLFNRLNKTLAENPSTYLVSHRLSKQNQLRRRQYRSSELLVSEVMENVCATYKNDDRLLRLHPKSKVRLYHQQIFGDARLGVRHALREDEVYPADADPAAWDNKLDGHLYPVARLYSVRDADALHGMQSLSATPTMCALLVEEAEEEIEELVKTARTQAEVEYRLCGMAFPLNKSFSTLDVETKENEVSLAPPITNVCADVEVLRAAARRDQERWEQYQRREAKRKVEIAQRMETAADVAGAATSELASEASTNTEVAAALDRSTPAAAGKSVDSSTEEATNNPVGGGDKEVSDNYTDGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZ54</accession>
    <name>A0A088RZ54_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_323930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702074.1">
        <property type="nucleotide sequence ID" value="XM_010703772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZ54"/>
    <dbReference type="GeneID" id="22578134"/>
    <dbReference type="KEGG" id="lpan:LPMP_323930"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320046600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_323930"/>
    <dbReference type="eggNOG" id="ENOG502S4W5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2942533at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101031">
        <property type="term" value="C:protein folding chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051966">
        <property type="entry name" value="RPAP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46423">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46423:SF1">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="224" mass="23996" checksum="43DBFAB43C9A67FB" modified="2014-11-26" version="1">MNGRQTQLICVTVAAASLLGALSYVAYRQLSQDRPGSLGGKAQASKFPVRAPAAAADADALTPGPQVPIELPAESPYLAADRGKALKLLNVLKQEANIAFQEGRFEDALRGYQDCIEVTSVLGAADTEAVKTEQIVRANVTMVCIRMHEYDAARAVATMLLQDAAVALPEDLKVKVLYRRGLASKALNNRTAALADFNAAVHFSKDHRNPVVEKEIALLQRGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZI7</accession>
    <name>A0A088RZI7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">60S ribosome subunit biogenesis protein NIP7 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_331420</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with pre-ribosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the NIP7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702234.1">
        <property type="nucleotide sequence ID" value="XM_010703932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZI7"/>
    <dbReference type="SMR" id="A0A088RZI7"/>
    <dbReference type="GeneID" id="22578295"/>
    <dbReference type="KEGG" id="lpan:LPMP_331420"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330020000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_331420"/>
    <dbReference type="eggNOG" id="KOG3492">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27490at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042255">
        <property type="term" value="P:ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21146">
        <property type="entry name" value="Nip7_N_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21151">
        <property type="entry name" value="PUA_Nip7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.10:FF:000002">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.220:FF:000001">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040598">
        <property type="entry name" value="NIP7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055359">
        <property type="entry name" value="Nip7_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016686">
        <property type="entry name" value="Ribosomal_synth_fac_NIP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005155">
        <property type="entry name" value="UPF0113_PUA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17833">
        <property type="entry name" value="pre-PUA_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03657">
        <property type="entry name" value="UPF0113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017190">
        <property type="entry name" value="Rbsml_synth_fac_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88802">
        <property type="entry name" value="Pre-PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUA" evidence="7">
        <location>
            <begin position="96"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO01434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="181" mass="20662" checksum="C1B66D92143BC6EA" modified="2014-11-26" version="1">MRSLTDEETKKLFDKLAQYIGANTTHLLERKGEEEHVFRLHKNRIWYMPLRLAKLASCVSKTNLMGIGVLFAKVTHNGNVRIQVTALEYIAQYSLFKIWVKPNQEQRFLYGGNVSRAGLGRITESTPKYQKVAVFSMGDIPLGFGVAAQSTLECRKCEMNTQVLFHEADVGEYLRDEARMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0L4</accession>
    <name>A0A088S0L4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_341010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702526.1">
        <property type="nucleotide sequence ID" value="XM_010704224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0L4"/>
    <dbReference type="GeneID" id="22578605"/>
    <dbReference type="KEGG" id="lpan:LPMP_341010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270009300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_341010"/>
    <dbReference type="eggNOG" id="ENOG502SG5K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267547at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="647"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="652"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="693" mass="73375" checksum="2CE2B8B502EE497A" modified="2014-11-26" version="1">MPPPRSVSMKRRAVGAEPHYESATFSPQETESMALTSATTTTTMSGRRSTSTGSGKGQGSAAAVHETPMVTSSIGSLSLLPMKTTTSPSLVSAATSATNERKRARESAERCSIRRLQGGRSPSASATTGGSTRPLQRLCRSESFGSDKSRISDTPQLRRNTTCAELDVEEVFFESVTRASPAHLQHTPTSQLLSQQQALPYSTLSEDHGVAPQGPALEQTLFTPATVARRPKPQTVLGEALRSSALSAASAPSAASPASSSASRLSSHDEAVQAILRANPPTTTRPVQLKPGYNAPSPQTPLWAALEDDRDEDDHAALGSGQALEELLLSNTQVSLFQLGDEEEANTSGAVRTTTRADALPCSRHASVITAPTVSTVGVHVPATTHECRRLGTRAAANGSISLPAPGRSLNLLDEDGLHDDERLPLFVGMESDSQDDGTDGEAFSLTQEANRQERARDMQAALPRSRAYRGAASAAAARASAAATLHAGKLGSADTFTPSPTRQRATRASHTTVQQQGSPYSQLQRVVESTMAAATVVAAGQRHTTTPVADTKPPEVLSQKELRRKTDMLRWAERTRAFFHFIDTRPLHVTSSPLKLPASTSSQARQGRCSQSVVTSHYRKRIRAVQTHKSRTPATSMSLACRSHSASTVRSVPSPSVAAHGSSSSSAFEDVISRVKREAAAAATSTRSTSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0M0</accession>
    <name>A0A088S0M0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_341720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702599.1">
        <property type="nucleotide sequence ID" value="XM_010704297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0M0"/>
    <dbReference type="GeneID" id="22578677"/>
    <dbReference type="KEGG" id="lpan:LPMP_341720"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340023100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_341720"/>
    <dbReference type="eggNOG" id="ENOG502SA6B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265374at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="686"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="736" mass="78120" checksum="D6512BF9D6662C54" modified="2014-11-26" version="1">MLLQDDLTAQQLAVISRVALLLQQVTLSTAISKPTYGIGALREVGETTGATVATLPGLKTAGSGCGVTATQIYTNTRDCSANGTKENAADRAVLQKPLQIPLVNTDESVNTLRQLGWLLDEATQQLQASVDAQLVDFYAHLRGKASATLPTGSELKERVTLAHGSRQDRLTSPLISRALSRRVPRPLHLAIGPSWLNDDKGAGARTESAGSCTTFPLDINGAEEALPASNTTAGAAVSATATPGVDCVRTESPFVPLVSISTARPLNAQQPQRCAQSRVSSSSGLHNAPMARRLEEERAAASELQSFFSLLLEAALRLSGASAAAVYMDDALPLGTGGAGETFYHPTTTVAAASDTAGSGRAQFLHCVAHSRGHFPSSISYATSNVLTTVVTTGVAVNVHYSESSLLHFGTSGNFRPGASDSGRHSMLTGGSTTVTDASGRRLGNGSSSCAGHLFLDMYNGVIVPIKGIGCLVLANKVKTAASDVTSPRFSIFDEHVAWSVALLSEAILHQYERQLLLRASWSPSCVNALRPYIQENGPLPSSANRLPARDGASVMRERRGLQSRVTSKRLFTVKSAAAAKLSAVDVDNVAVSSLVFDPQNDIFSRTLTMVRTGDPQVLKALPPELRAFSSISSSRRAVNTVSGAVVPEAVTSGSSAKLNDEEVFQAAAQYITNLESLWRRTISESNTMRIMVENYNKEMQRQEETIALLEAKVRELNVHMAQLERRGNGTRLSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S107</accession>
    <name>A0A088S107_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_323260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702010.1">
        <property type="nucleotide sequence ID" value="XM_010703708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S107"/>
    <dbReference type="GeneID" id="22578067"/>
    <dbReference type="KEGG" id="lpan:LPMP_323260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320039100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_323260"/>
    <dbReference type="eggNOG" id="ENOG502S6WC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270160at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="117" mass="12834" checksum="D65909487AF56C00" modified="2014-11-26" version="1">MIYVPFVVGAGAFSILNACGSIACWYGSRRRVMLLTGAINTCISGAAVVMYPYDAKLSSVYMCAAATSASAQYLLHAMRTPQLLAPSMMNSLYVLWSVGLLVYAFQHARWVYALRYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S119</accession>
    <name>A0A088S119_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dymeclin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_010400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dymeclin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009370">
        <property type="protein sequence ID" value="AIN95141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696683.1">
        <property type="nucleotide sequence ID" value="XM_010698381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S119"/>
    <dbReference type="GeneID" id="22571769"/>
    <dbReference type="KEGG" id="lpan:LPMP_010400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_010008400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_010400"/>
    <dbReference type="eggNOG" id="KOG2225">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253409at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019142">
        <property type="entry name" value="Dymeclin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12895">
        <property type="entry name" value="DYMECLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12895:SF9">
        <property type="entry name" value="DYMECLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09742">
        <property type="entry name" value="Dymeclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0519">Myristate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="707"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN95141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="825" mass="88172" checksum="088817380B445E7E" modified="2014-11-26" version="1">MGAAQRKEASEYFTAALTSDAATAPDELEFLSKVKQYERSLCNGSELYGVAEPIAAAVMSKTAETGRVRWLLRLCSEVMRRCVEAPHSIDASTPAVLHLAELLLRHILRLTKGWSAALANVLEATGKCGEEIPSGDAPLEDTAALLCRMAFSFVVRVPLDAATVATHFGVLRLLLTMTSTALHHGTEFQEDTMDLFTELMLSSPLLDECLSTLLQTVVSWGKLSWTAKSPALYHEGHQPSFLNLFHVFSTPATAPGFASGKGAYVLEVPCSMTSNAASAASGAGASSASTSAHPTDPAAVLMKSCSCWEQVGRHATALLCVLVVYQKGGARNPALEYVTAIRDGTPVSFVALLSAIRSRLTSFPEVLILLYVLLHDHCTFLHTALTEDAALLVSTMQELLEMTSRTCRNTARPSQAAATGTTGDVLQNAVLGRIIFQLRIFSYPFINFMASTLLLLVSQDRVVNRLLCNTPCLGKHLLERYDAKASVGALAVVVLSLGILKGLTERNEALIAVFAPCLVNLAPFVQGMDSYTAQRVSALLTLALKKIHRASALLMASTATTTAEGNTCASTTAETVGQPTAAPDDVGSSISSTRGSITTVVTSAEDVRALEEILTMYLRQLRIVVEGVESLLRGASRHNEHLIYELLYVRNRIIDDVDAAVEAQCPHAQPTKQLLTNLADMIRNCEADIASSNQAQSPPEILAILRRGQQAQQQQQHDQGKSGSISGNNRKDASGGDDGGGSYTGVSVSRASSLMAEPSVAVTIAADAMTGSDGASVDLVYSYEESPHSYDFFGPFVWATLLSAGQLPGAALWCRHSSELPLFPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S198</accession>
    <name>A0A088S198_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Heat shock protein 83</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">HSP83</name>
        <name evidence="12" type="ORF">LPMP_330370</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702130.1">
        <property type="nucleotide sequence ID" value="XM_010703828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S198"/>
    <dbReference type="SMR" id="A0A088S198"/>
    <dbReference type="GeneID" id="22578190"/>
    <dbReference type="KEGG" id="lpan:LPMP_330370"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330008200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_330370"/>
    <dbReference type="eggNOG" id="KOG0019">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276124at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.790:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.80:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11260:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000001">
        <property type="entry name" value="Heat shock protein HSP 90-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="11">
        <location>
            <begin position="25"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="211"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="674"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="224"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="683"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="696"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="98"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="118"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIO01330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="705" mass="80907" checksum="AF8312B058703C87" modified="2014-11-26" version="1">MTETFAFQAEINQLMSLIINTFYSNKEIFLRELISNASDACDKIRYQSLTDPSVLGEETHLRVRVVPDKANKTLTVEDNGIGMTKADLVNNLGTIARSGTKAFMEALEAGGDMSMIGQFGVGFYSAYLVADRVTVVSKNNSDEAYVWESSAGGTFTITSVQESDMKRGTRITLHLKEDQQEYLEERRVKDLIKKHSEFIGYDIELMVEKTAEKEVTDEDEEEDESKKKSCGDEGEPKVEEVTEGGEDKKKKTKKVKEVTKTYEVQNKHKPLWTRDPKDVTKEEYAAFYKAISNDWEDPAATKHFSVEGQLEFRAIMFVPKRAPFDMFEPNKKRNNIKLYVRRVFIMDNCEDLCPDWLGFVKGVVDSEDLPLNISRENLQQNKILKVIRKNIVKKCLELFEEMAENKEDYKQFYEQFGKNIKLGIHEDTANRKKLMELLRFYSTESGEEMTTLKDYVTRMKPEQKSIYYITGDSKKKLESSPFIEKARRCGLEVLFMTEPIDEYVMQQVKDFEDKKFACLTKEGVHFEESEEEKKQREEKKAACEKLCKTMKEVLGDKVEKVTVSERLSTSPCILVTSEFGWSAHMEQIMRNQALRDSSMAQYMMSKKTMEVNPDHPIIKELRRRVEADENDKAVKDLVFLLFDTSLLTSGFQLDDPTGYAERINRMIKLGLSLDEEEEEEVAEAAPAEAAPAEVTAGTSSMEQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1A6</accession>
    <name>A0A088S1A6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_330470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702140.1">
        <property type="nucleotide sequence ID" value="XM_010703838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1A6"/>
    <dbReference type="GeneID" id="22578200"/>
    <dbReference type="KEGG" id="lpan:LPMP_330470"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330009300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_330470"/>
    <dbReference type="eggNOG" id="ENOG502SIFW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264016at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="288" mass="32055" checksum="20E2C497EC49B7D1" modified="2014-11-26" version="1">MHQLRIFKYVASELGHDEPVLHAVVVTHRCLPSDPLEEHFTSTIPHTVTSASRKLSSAEASVGADVTVESTAAVTSNGTLAVPLEVALTVEQELANLDNRLASWKEQRLADLQAPGSVRASSSSFQMEVAMEKRLARKRIEEQDRAQHRMNLLLTSLGPRIDRQLQLMTREHDSEQASASSSAKVAATSNVNDSAGASRSTTTATTLPPPSPRARILCDQQYVVTRQEIVLEERVTRQTLLRNLWDVRRLTHLVEDEVLFRRSIETREGMWRDRLNGESDASVEVDCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1N3</accession>
    <name>A0A088S1N3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Macrophage migration inhibitory factor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">MIF1</name>
        <name evidence="2" type="ORF">LPMP_331830</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="PLoS Negl. Trop. Dis." volume="10" first="E0004326" last="E0004326">
            <title>The Dynamics of Lateral Gene Transfer in Genus Leishmania - A Route for Adaptation and Species Diversification.</title>
            <authorList>
                <person name="Vikeved E."/>
                <person name="Backlund A."/>
                <person name="Alsmark C."/>
            </authorList>
            <dbReference type="PubMed" id="26730948"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MHOM/PA/71/LS94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KM411850">
        <property type="protein sequence ID" value="AKK31295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702275.1">
        <property type="nucleotide sequence ID" value="XM_010703973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1N3"/>
    <dbReference type="GeneID" id="22578336"/>
    <dbReference type="KEGG" id="lpan:LPMP_331830"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330025400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_331830"/>
    <dbReference type="eggNOG" id="KOG1759">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="255819at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001398">
        <property type="entry name" value="Macrophage_inhib_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01187">
        <property type="entry name" value="MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="Tautomerase/MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKK31295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="74" mass="8009" checksum="C2938B55C12761E8" modified="2014-11-26" version="1">MMTFHGNTPMHFLGSTDPVAYIRVEVLGGCCPLEPEKVTSLITAADTKECGILADGIFVLYFSPLHCGWNGTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1P8</accession>
    <name>A0A088S1P8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">P21 antigen protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_345120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702931.1">
        <property type="nucleotide sequence ID" value="XM_010704629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1P8"/>
    <dbReference type="GeneID" id="22579017"/>
    <dbReference type="KEGG" id="lpan:LPMP_345120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340059400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_345120"/>
    <dbReference type="eggNOG" id="ENOG502S378">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="256076at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039683">
        <property type="entry name" value="Lsm12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13542">
        <property type="entry name" value="LSM12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO02131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="191" mass="21245" checksum="11192E13743632FA" modified="2014-11-26" version="1">MSIIKEDDAVGCYMALTLVDDTKVEGTIFTYNPKEGIIVLLCLRDDQTNMKLIRTPYIKEFSISHAEEGSHLPPALDSFNELPSMHAGRGKSIFKHASTQLKNAESNREKHFNSVAADTSIATLDAYLKLLRLYPFIEWNNEEGVIQVSDTVIVVGDPDWRTPKAMLVEGAPEKDKPLVDRLQVALGSGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2M3</accession>
    <name>A0A088S2M3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">tRNA-methyl transferase, putative</fullName>
            <ecNumber evidence="2">2.1.1.61</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_070150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.61" evidence="2"/>
    <dbReference type="EMBL" id="CP009376">
        <property type="protein sequence ID" value="AIN95701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704023.1">
        <property type="nucleotide sequence ID" value="XM_010705721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2M3"/>
    <dbReference type="GeneID" id="22572350"/>
    <dbReference type="KEGG" id="lpan:LPMP_070150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_070006300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_070150"/>
    <dbReference type="eggNOG" id="KOG2805">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3685at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004808">
        <property type="term" value="F:tRNA (5-methylaminomethyl-2-thiouridylate)(34)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000352">
        <property type="entry name" value="Putative tRNA-methyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000418">
        <property type="entry name" value="tRNA-methyl transferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046885">
        <property type="entry name" value="MnmA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11933:SF5">
        <property type="entry name" value="MITOCHONDRIAL TRNA-SPECIFIC 2-THIOURIDYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11933">
        <property type="entry name" value="TRNA 5-METHYLAMINOMETHYL-2-THIOURIDYLATE -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03054">
        <property type="entry name" value="tRNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20258">
        <property type="entry name" value="tRNA_Me_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="tRNA-specific 2-thiouridylase MnmA-like C-terminal" evidence="1">
        <location>
            <begin position="484"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="593" mass="63698" checksum="E5B60AD9E9AE327F" modified="2014-11-26" version="1">MTRSQLRIAIGLSGGVDSAVAALVLERCVHTALDVAALRCFGGPRAPPPPLPTLRAAVDARTPLHELLGKLVTPGKPGSPAAGGDATPVQYTPFFMRNWHDDKAASGWCVRAQVDYDDAHQVAKTLDLLPRDGTPLPSYDFSSEYAEQCFERMLDAYAVGHTLNVDVLCNSKIKFGALMRALRRTGSAFSETLLATGHYARTWNLSRGDHGGSDERQPVLLVRPCSAGRDLNDQSVFLSRVPPSALASAIFPLGHLFTCKADVRALATHSFGHSGGMAAVAHIPQKKTSTGICFVGPPSAVTRAGNTSCSSCFPSFLNEYLPPPRPPLLQSTRTAFCDAVTGEELFVPGDTATHATDALPQSIVGRLSHSPPFGALREDYPGCLPAYAFTLGQRVRLCRRTPDGRGREAVHYVASKVLAPLPPSALSDGKVPPVRVLAEVQVVAEWNNALLYTSQATVASLRWWLPRPVLHQRAATCHKHRIYRLRCHCCTRHQEALQPATVEWEAADEELSADAAVRVSRARVHFDAPLRAITPGQALVAYTSILALEEGWTTGHNASHGDTEPFPPETMAVIGSGWVVPSDSPPPGGPSLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2X3</accession>
    <name>A0A088S2X3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine phosphatase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_343040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702730.1">
        <property type="nucleotide sequence ID" value="XM_010704428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2X3"/>
    <dbReference type="GeneID" id="22578809"/>
    <dbReference type="KEGG" id="lpan:LPMP_343040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340036800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_343040"/>
    <dbReference type="eggNOG" id="ENOG502SJI4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="414418at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051710">
        <property type="entry name" value="Phosphatase_SH3-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469:SF27">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="697"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="825"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="868"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="472"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO01930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="898" mass="95812" checksum="2F990727556A7EDB" modified="2014-11-26" version="1">MPTNLSVVSPYPSQRVVVMRHGERRDSASGTPAESNPPLTAAGVAAIQSVAARLKGHLGADAAYRAVLIVSPFLRTLQTAEALQHHGVGAARAMVIDNTLSEVFGPCRIKTQRAPQLQVPPLSHVVGALPSWGESIEKATKRFVANFLRNGDVYGGYLTATSFPTDASLSGKDGLPSSQSPLLESVPRLNKGRLPPRNLPPGALVSRNTRNLSNMVDDQPCDVILITHGDAISAVVSHFYPSRVVYEAEFLSYVIMQRHGVGNRVYHLEKSVGVNWLVEGIDAEPQDPILFNLEKQRLVAESGSGAGYDNDNGGDRLEDGADVPINLAGSRMQPRHVGGIPDHSHANRGVQFTARSNAEASSPAEVVNMHNPTTHSRTTRGAANNRDLRGSSFPLATHAPMPLQVPEQSPPPTHQHHHQPSNALQDPPYNNPLTATTDAAVASAFPQSPYRHPNAGEGCERIRLPTGTPAQSSSNSVSNYGHSSGECAEDTEAAGNGSSSPQQRERERPLKGAESVSNLCYSTEERETEKGIMLDESNHVPIVPLLSDYRGLSEEPSIGLWARPPSMPATFLSAATTTRIDESRPLPHLETTSAVATAGVLVSYGSDAAAPADKSFETDCAEDGTVVRGGASLMILPHPTFSTAVAVGASGDSADALNRRIDRQQSVIYDSFVSFALRAAAVFLILFNVLVQRHDTATLWFGAFALTWEMGFAVVLYCSCQPSGWRMRRIRSAVEQLHFSVPSARGRATTARRQCVVMCDADSPDGASDDSSKVQPLCGFGRSSAGAAESINSVESSEGSDSVGRDALAPNGVLKRAVLSVLCGIRLVVATVLKLVIISVLSFVFAFLCGSPAPGVMSVICNIYESTVGLVLLLTYGCVCVVRGLWDERRLDGVIDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S356</accession>
    <name>A0A088S356_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_357000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703628.1">
        <property type="nucleotide sequence ID" value="XM_010705326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S356"/>
    <dbReference type="GeneID" id="22579728"/>
    <dbReference type="KEGG" id="lpan:LPMP_357000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350079800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_357000"/>
    <dbReference type="eggNOG" id="ENOG502S671">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="46529at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839209" description="Thioesterase domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Thioesterase" evidence="2">
        <location>
            <begin position="69"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO02828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="159" mass="17397" checksum="F577E21041923F40" modified="2014-11-26" version="1">MLGTHFLLNLVTTKQAAAAAQQLMGNPKNYSAALLRTVLFSPERIQVRSEGTLVFPWEAKRGSQNGIKSVHGGALSSLADAFTKIHAQAYLPQACVESVSFEISFLSAVFEDKKCNCMTRLVRLEDTIVFTDFLFEGEGSDEVYARGTHVLTANPRIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3G1</accession>
    <name>A0A088S3G1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_091110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN96026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704348.1">
        <property type="nucleotide sequence ID" value="XM_010706046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3G1"/>
    <dbReference type="GeneID" id="22572681"/>
    <dbReference type="KEGG" id="lpan:LPMP_091110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090016600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_091110"/>
    <dbReference type="eggNOG" id="ENOG502SDXQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266535at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="529" mass="58857" checksum="4AB4306BC1ECB48C" modified="2014-11-26" version="1">MSASSVASLLRASPLYLYSRRSLLLLLPTRPPTPAATTSTLSVASNCSQAPSPSHQYRLVHAVSFNLHRTMFLFRHSAEPKENDEAHHDPVDNAIKQEETALAAPDEHKASAEMAGNDALHEVSSSADSYESPESARNPSREGTVPPPDLGDMMEHPYQHHEDDVEADVAAAVPATSAPMPANGISTLPMPRTYNAAPPTAVNGNGVQRHDNHSYNSRGAAPSPRSTSGISRGRSYSLSGLSAAELADVYDQQYRRCSSVVRSARSLVARRASSVNGVVGVMDGFGTSASSRGSPMTEEECIAVERMMENEYRRQEVAERMTQYALARESIIVKEELAREKATYMRRMHMDAELHARLEKSGRNRQERMAAAAQRRQEHEQERLRILYDSMAEKDSRYHFHNPYAMMAAQRRYSVEVRHSVSITPQRRASSPFTIKRNGNSLTSPRTNEEVTNGNTDDRRTSSPVTRARSTNPRIDQSKPLKCLPLDAWKVPEQPRKKSPKRDSSTARRALSPKAWRAAVVPDHPRHWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3L3</accession>
    <name>A0A088S3L3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chaperone protein DNAj, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_356430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703571.1">
        <property type="nucleotide sequence ID" value="XM_010705269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3L3"/>
    <dbReference type="GeneID" id="22579671"/>
    <dbReference type="KEGG" id="lpan:LPMP_356430"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350072900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_356430"/>
    <dbReference type="eggNOG" id="KOG0714">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000076">
        <property type="entry name" value="Chaperone protein dnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000013">
        <property type="entry name" value="DnaJ subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000015">
        <property type="entry name" value="Heat shock protein 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051339">
        <property type="entry name" value="DnaJ_subfamily_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078:SF553">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="4"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO02771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="341" mass="37448" checksum="93B2ECC535CFF39E" modified="2014-11-26" version="1">MGVDYYKVLGVSRNAKPNEIKKAYHQLALKYHPDKNTDNREKAERKFKEVSEAYDVLSDEKKKKIYDLYGEEGLKGGVPEDGGAGMGGAGMPTGGMPGGFHGTTYHFSSTDAFKIFNQFFGSSDPFVGGEAFGGGGPGLHRVFRGYGGPEGFTTGFGTPQASPTCDVPPMEYTFACTLEEIYTGCTKKFNVSRNTPSGAEKKMFEVKVLPGYKKGTKIRFEREGGRVEGYPPNVLADMVFILDERPHPRFERRNADLHTTLHINLKQALLGSTVFVKGIDGQTISLPLNGVSKSGRKLRVSGSGLPDRKTNRKGDLYVTIAVDFPDVLTEDTKRLIEQCKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S416</accession>
    <name>A0A088S416_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAB1-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_101020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696824.1">
        <property type="nucleotide sequence ID" value="XM_010698522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S416"/>
    <dbReference type="GeneID" id="22572839"/>
    <dbReference type="KEGG" id="lpan:LPMP_101020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100017200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100017300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_101020"/>
    <dbReference type="eggNOG" id="KOG2375">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2275718at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045117">
        <property type="entry name" value="ATXN2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009604">
        <property type="entry name" value="LsmAD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025852">
        <property type="entry name" value="SM_dom_ATX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854">
        <property type="entry name" value="ATAXIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854:SF7">
        <property type="entry name" value="ATAXIN-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06741">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14438">
        <property type="entry name" value="SM-ATX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01272">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LsmAD" evidence="2">
        <location>
            <begin position="149"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="412"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="439"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="520" mass="56381" checksum="E4550F49C3F41130" modified="2014-11-26" version="1">MIGPNESSNADRLEYLYLNLVGQTVLIHTVDGALCEGLFVSRTDADVAADEAGVFISFPRNLPSVVHSALDASELSDETRLFRYEDIMMMEAKNMKLRTETPGAGHVHSYRGEHDLKTLDWAAEGADELLEADSHVTGQWDQFKANERFGVASTYREELYTTKLDESKLSKEQIAYAERTAKEIEGSGTRNLQHRLERTDVTTEYVDEGSMFSDVARDARGSKRNVPATRKEVAAAAPVASAVPATTAAATTATVGRGTTRQAAPAPPPPEEPVTLPPPPVPEVSAVQHKTVYSPNPSATPFVPPLKSFLANVAHLVANNDNCYACPTDWPGDIDFYDRDVSHYSRPQAPVQPNMHHKYNQPVMNPMPGRGAPMNHHQHHAMNPHPAVYNTSGSMGGHIGNPHLQQQHPQYMDPGNNNNGMMPPQGPGAMPGPSPARMQQQRTKTSQPQQPVHTATQSIPPPQQQQPHQQQQVSAIDSSGPQQDRAVSGAKKLRRGGMAAAARQDGGEGAPQGGNKKSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S445</accession>
    <name>A0A088S445_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Tyrosine aminotransferase</fullName>
            <ecNumber evidence="10">2.6.1.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TAT</name>
        <name evidence="10" type="ORF">LPMP_352430</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.5" evidence="10"/>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703180.1">
        <property type="nucleotide sequence ID" value="XM_010704878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S445"/>
    <dbReference type="GeneID" id="22579272"/>
    <dbReference type="KEGG" id="lpan:LPMP_352430"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350030700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_352430"/>
    <dbReference type="eggNOG" id="KOG0259">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1691396at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004838">
        <property type="term" value="F:L-tyrosine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005958">
        <property type="entry name" value="TyrNic_aminoTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01265">
        <property type="entry name" value="tyr_nico_aTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45744">
        <property type="entry name" value="TYROSINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45744:SF2">
        <property type="entry name" value="TYROSINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000517">
        <property type="entry name" value="Tyr_transaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="9">
        <location>
            <begin position="75"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="44"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000517-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIO02380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="449" mass="49916" checksum="182F5C8E93D2AEEA" modified="2014-11-26" version="1">MTTDSPTSPAAQALKVSNSTGSLTEEERRELQQQRIAENASFRRITSSKHAQNTLQPVNDLTNNLKPSSSTKSNLRLSIGDPTVDGNLKAPEIVTKAMMDVVSSGKFNGYPPTSGTNHLRQAISTYWRRFCQTKSRQEELQWENVIVTSGVSQAILLALTALCEVGDNILVGAPAFSHYKSVCDSYGFECRYYTLDPSKNWECDLNEAAGLVDDRTKAFVIINPSNPCGSNFSRAHVNEVIEFCEHRQIPLISDEIYAEMVLNNGIFTSVADFDTNLPRLILGGTAKYQVCPGWRVGWSILVDPMNVAADWNLGMERLAQLICGANSICQEAIARTLLECPASYTADIVSQLEVGAKVYNRLLEHDIGISFDPPQASMFVMLKVDLSYFKDLKSDTEFYEKLLDEENVQVLPGEIFGMSGFIRSTISRPPEVLSEAVDRIIEFCERHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S4F4</accession>
    <name>A0A088S4F4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_120280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009381">
        <property type="protein sequence ID" value="AIN96356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697009.1">
        <property type="nucleotide sequence ID" value="XM_010698707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S4F4"/>
    <dbReference type="GeneID" id="22573034"/>
    <dbReference type="KEGG" id="lpan:LPMP_120280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_120007600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_120280"/>
    <dbReference type="eggNOG" id="ENOG502RYVD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5792673at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="197"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="575" mass="62789" checksum="EE0910BC2AA26A06" modified="2014-11-26" version="1">MSRLAHTEQRAMSTLSASSIALAASSVSRRSKRLSYADADKVYGEKATTAPSWSLLQGPHTESSSTSVFTRGTTTYHASLRTRAQQRWLTLLLRLMRTPYVGALAMRVLEAAAYAAYVKGSVMLFTRRRVGPPVATATGPNSSCEIDMCKAHCKGDLSMVGTFSASSSLSPAGRPSAAASSSLPFSHGAPLREHALDCLYIGNSPIHSRGLFTARALPRGTRIIAEPRRSLLLAPHFATLLADTHEKLPDTWHYTQPTGCIVELVTQAQPHHLMNHSCAANVCSGLSHTFWEAATIAGKWQQQRLSRSSSTAGGGNERTEVPHSNVKGGRIRSGTKNRSSLSSPSSFVTQSHSADWRERLTLWSHFADANSFFVTRDIAAGEELTLDYSTRMAPLYAGELARALQSRSWLLCRCGQPFCRHYVYRPTPEVISFLRALHTGRCGQERSAQPPGQQSAPRMPDCAAPPSTMDVCDPLHVMAKLLELGFDDELVLLSYAASSADVVAYLYGQPLPSLQRPSLTQPRASFARRSLSSASALSAVQEGIDVEVRRVSKRQLLAEYRYVFRILNEAVPVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S4G3</accession>
    <name>A0A088S4G3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_120380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009381">
        <property type="protein sequence ID" value="AIN96366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697019.1">
        <property type="nucleotide sequence ID" value="XM_010698717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S4G3"/>
    <dbReference type="GeneID" id="22573044"/>
    <dbReference type="KEGG" id="lpan:LPMP_120380"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_120008700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_120380"/>
    <dbReference type="eggNOG" id="ENOG502S9M2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="262622at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="37273" checksum="217780C2E394019E" modified="2014-11-26" version="1">MTALSMPASSSAAPNLRNSRLEATCESYGVDSRLLYNDIERLSKKRFDYAQRLVLWSRLLSVVSLLTAGATGLAVYYQRAQIYRVWRLRNPRKVQQLGQLTMLSGCFSLCSVLFLISPVGFMRLHEKELQRTKQLDAIAVAALVQEQNFRTVAAWARTAADTRRLAPASSSSSSTVSPSPTIAAATETVGRGREEQGGIGPELQWVWSEVVLDPSQLLQPPFDCETQQKPVGTVNTVKPQPPPAGSAGAAAAAVTDADPDMLAAKKRLASQLLGNSEIFDNSTRGDSDAASAAEPLTWRQQSRRVWSRTADPMELQHLKDECVAMWEGLVAEKTSIVQQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S4Y3</accession>
    <name>A0A088S4Y3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoside triphosphate hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_131390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697219.1">
        <property type="nucleotide sequence ID" value="XM_010698917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S4Y3"/>
    <dbReference type="GeneID" id="22573249"/>
    <dbReference type="KEGG" id="lpan:LPMP_131390"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130018600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_131390"/>
    <dbReference type="eggNOG" id="KOG0740">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3046016at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052267">
        <property type="entry name" value="N-DRC_Component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14690">
        <property type="entry name" value="IQ MOTIF CONTAINING WITH AAA DOMAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14690:SF0">
        <property type="entry name" value="IQ MOTIF CONTAINING WITH AAA DOMAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="679"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="944" mass="104851" checksum="C189F4B29E2C585D" modified="2014-11-26" version="1">MSTLSYQQQYQQILADLTELQREDVYVGALRIPEDAKTRQAYYAQYWLALYVRYLRLARQLAVIHDMELQPQRRCDVRTLLDSCLGRMLEARYSIVEHCGDYVALDDTLEEMKLSPAELEPPLPTYLLEDRHEALLQDRAYVMSLQQHYKETESEAAPVALAAAAHSAALFAEDPTKALPPFATTAKVAATADDKSAPMPVEEAVRIVQLAERGRQARQRSTIQLQLFRQQQYAAMHGAALQSLTGKDRAATIVQKVALGYLQQKRAKARYQQEQELLGMTSTAAIRSDAARVAAGVRHDDRKAQQRVNQAELMQKTLEMSRQLKRQEGPKTLEVMLDEMLMHMAYAHLDGRAKDGVMDIPAVEDGGTLTLLGRRTRKNDLASFSGGAEASGGKQASLAAIGHSGRSASHAPDGDEVVIAGTKTDRRQSSRRRDDGDAAASALPAAPPSVFLDHVSSTAERHNTLWMEYFQRTRVEKGDLDQPYDEALLRRELMDGPRGVMQDLRRCVDQLVMMEVNNLKERLEAERNAGKKRKGGRKAKKTKAAKKPKLRDPTKGEDLVSYLNTTIYENKLQLPPPAVRLSSFVGPLDISGGPLDRLLRTQTVDKEIEKKWRRVLRGWNDEVEQAIGMPKDKIEALFNAYVQQSSWLRDPSAAEVRSAVTDYAVLPLGSQVIHDLAPHPTGLLLYGASGSGKTLLSYAIANDSGARFFNLSPGNFLTAKGIAKMVQIVFYTARMKGPSVIYVDRIEKIFPGKGAKRGKKKDDEMARGKRLKKELLKGIASLQPTDRVLVVATSTEPWRADTTALCKCFQRAVHLASPNFAAREALLHSFIKARLEAAHVTAITSTTEASIGETVRHISLLTNGFSAGQLRDCVTQTLTAYRLERLAHNPIAAEEFAPALAFMTGLSAAEVKCFHDFQASLPVTMRRANAIEDFKPSEEEAKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S4Z4</accession>
    <name>A0A088S4Z4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD-dependent oxidoreductase domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_355800</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). Involved in mid-late stages of complex I assembly.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703510.1">
        <property type="nucleotide sequence ID" value="XM_010705208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S4Z4"/>
    <dbReference type="GeneID" id="22579608"/>
    <dbReference type="KEGG" id="lpan:LPMP_355800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350066500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_355800"/>
    <dbReference type="eggNOG" id="ENOG502QV5V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF287">
        <property type="entry name" value="FAD-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="5">
        <location>
            <begin position="35"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="674"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="316"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="686"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00039785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO02710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="716" mass="78902" checksum="72E2051450D1775A" modified="2014-11-26" version="1">MGQRGSRMPPVDTPVGDSVSPNLTERLSLTAPSAAVIGAGVAGVHVAYELARLGFKVTVFERRGDIAGGETRDSLPFVGVGLIEPSLSRTALRNEVLRGMLFPTTCPDLIAREHLFNILLNPVVYRWMWGRARSCFSDVEVMAYTNNLSCVSHSVVCELVKKYPHLHQHVFAGPITVLNEQKEPAVTAHAAPLMIDPVGWTRALADVCARYYGVQFALGERLEDTVTYLKYNVESTRSIRVSKPDPLHPEQRLFACEGYDVVVLAAGASTGTMTLPNSRLPVLGLSGLSAVVQQPNGALKDAIRSLFQGKPRRRPSAAATSFSPAADALSGGDGVVGSLARPTPGTLALLSSHCSLYGYTWPSTSSSTNSHDGLDGSSSAVASMMQSKVLPTPQDVVLQGLLSLDSTAKTETRALVLRQLDRLESYLRIKCGWSVPLSSFSTSTENERGSNVVRVREYVRAFTPDGVPIVDHNGGSFNCFVCCGFGDHAMDFAPGAAKVLGKLVEHQAQRLREEDIEKVKSWGLLTSKLSPSRRTEVEEELRLLFSGVNPEAVTRKQSMTRSEAPTLTWLRPEGNPYSTNRFINMVRKEVKVDDSPPILSRLYAFEEGLLTRLEPYRRRFHAKATELALRENMPDWLHTIVFCYMYEEDDSPDAQARKEKHLRSLQRLASQYETPVADAKWAGNGAEERSLTSTEHSKRQQTELERRVREVFTKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S707</accession>
    <name>A0A088S707_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleolar complex protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_181560</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697989.1">
        <property type="nucleotide sequence ID" value="XM_010699687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S707"/>
    <dbReference type="GeneID" id="22574046"/>
    <dbReference type="KEGG" id="lpan:LPMP_181560"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180018800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_181560"/>
    <dbReference type="eggNOG" id="KOG2256">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10266662at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030690">
        <property type="term" value="C:Noc1p-Noc2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030691">
        <property type="term" value="C:Noc2p-Noc3p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005343">
        <property type="entry name" value="Noc2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687">
        <property type="entry name" value="NUCLEOLAR COMPLEX 2 AND RAD4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687:SF4">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03715">
        <property type="entry name" value="Noc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="24"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="95"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="635"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="644"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN97336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="654" mass="73085" checksum="4F14F2AF0D026CD0" modified="2014-11-26" version="1">MAVTKEKKSFKKFAKKHLAGVIETRRKTAKSKKEKLERLEKKKTREAKHAAREEKEHMDQLERLKDTDPEFYSYLEEEDPTLLQFGKEDIDVVEENDGSDAETEVDDDESRDGNIDDDNEHADGDNGEGSGDAAPHRGRVTREELAQLTSTSSAMELCIDVFVSAVRELGYQVKEHPRPQSTRKFEEPALVKEALVSVAKHVGKHLSTFITGKGSFKSYKTRMVVKRLLMALSSVIGEGHIDAVLTSGLLHTVVPFVPLLHYVRGLTKAVLKASLNLCAAPEESVRVAAYMVVRSVATRAAGTRSMYQSTAFKGIFLTLIRTAHHYNIHNQGTVVFLMNCVVDLYGTDMEAAYQHTFVYLRQLAIYLRAALQQQTQSNVRAVVNWQYLNALRTWGAVVSTYAEPNQLGPLIHPVVQIATALMDLFSSPRMFPMHLQVVEVLNHIARRADGLYIPVAPYLLRILTSPSVALSHAPNGASSSPDQADLLFTIRVKKVQARSGAYHRDIWSEALYLLTEHLATHSHTVGFPESFWAVESTLNKLKTQVRVPKVHSSISNLLRHIQTTSQKIKSKREQANFGPCDLAAVKQFEDELKQQGTALTSYYHTMRQQRIDDLAAKHKDASGERVTLECVVAKRKGGGSAGGKRNRPQVRRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S7Q9</accession>
    <name>A0A088S7Q9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">3'-5' exonuclease</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Werner Syndrome-like exonuclease</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LPMP_201320</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698333.1">
        <property type="nucleotide sequence ID" value="XM_010700031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S7Q9"/>
    <dbReference type="GeneID" id="22574341"/>
    <dbReference type="KEGG" id="lpan:LPMP_201320"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200018300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201320"/>
    <dbReference type="eggNOG" id="KOG4373">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1920326at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06141">
        <property type="entry name" value="WRN_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051132">
        <property type="entry name" value="3-5_Exonuclease_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620:SF109">
        <property type="entry name" value="3'-5' EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620">
        <property type="entry name" value="3-5 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="13">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="12">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIN97626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="531" mass="61114" checksum="7E40C193F5F0B0E5" modified="2014-11-26" version="1">MWTEMMQTLQQQPMYLRIMGIDSEWFRSSPVAVVQFATSSHCFVLHISFFDDRALPTAVKEALCDPAIIKCGVGINGDVSRLRKEQDITIQSVLDVAHYSAFFGLHHGARSNLKVLAESVANLSIVKDKKITRSNWELPLPDSSVNYAAEDALASYLIGQNVMLKASEVYCMSANTFDIPRWLRHTSSIAAMKLRKLQQELWKLDVEKREKDKPMSDSDDHAACQVQASSCVKVRVLDRNGNFLFECSRKRAKFYVAEKSLAVITKSLAGDPRKALEIQFLFDPKVKTRRCIYYALGDCELQGQCPFAHGMSELHPDAAALVESEKPSCACCLGTKGLLRHAITPTSFRKFMPLPQRQPLEDDYLPLCQQCNSVLRPYYADEMRRCYTEAEESNSTTFRHNVMTKCCSYARLLLDTNKLAKIPANRCEELRQYVKRNWRSTFFEDFNPEFEMRTPVEQDEAFLKRLGRIVPDDVRAKVTMNILVGDDQEKAQQFNKRWRDYCFSMCCMIEKKSNRMSYDDWQTYRAHNREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S847</accession>
    <name>A0A088S847_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-related modifier 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_202560</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3/UBA4 homolog. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 6">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of the MOCS3/UBA4 homolog, then thiocarboxylated (-COSH) via the rhodanese domain of the MOCS3/UBA4 homolog.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the URM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698458.1">
        <property type="nucleotide sequence ID" value="XM_010700156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S847"/>
    <dbReference type="GeneID" id="22574465"/>
    <dbReference type="KEGG" id="lpan:LPMP_202560"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200031400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_202560"/>
    <dbReference type="eggNOG" id="KOG4146">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10248987at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01764">
        <property type="entry name" value="Ubl_Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03048">
        <property type="entry name" value="Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015221">
        <property type="entry name" value="Urm1"/>
    </dbReference>
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        <property type="entry name" value="RURM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MoaD/ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="modified residue" description="1-thioglycine" evidence="5">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)" evidence="5">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN97751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="103" mass="11049" checksum="CD824437414E0367" modified="2014-11-26" version="1">MDAMHKKIKISLSGGCELLFNKEGSITLVDVVPVGATVAVLIDILRRDYIKERPELFVDATGTNVRPGILVLVNGCDAEVFGGVQHVLEDGDEVEFVSTLHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S869</accession>
    <name>A0A088S869_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_202850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698488.1">
        <property type="nucleotide sequence ID" value="XM_010700186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S869"/>
    <dbReference type="GeneID" id="22574495"/>
    <dbReference type="KEGG" id="lpan:LPMP_202850"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200033800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_202850"/>
    <dbReference type="eggNOG" id="ENOG502SGKH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272452at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="426" mass="47066" checksum="F49E2450D3E23F3D" modified="2014-11-26" version="1">MGLMPRGLTTHRPSVGVLPYRTPPLSGLYRMRYIPPPEVGTLSDHPRSQCNSEEADDGVSGPIAACGPTTDLLARADTSSAAARHVEVHTQLLRASSLMTGDIDLFSLYSVCEVEPVLCKCCTLQTQTTLNTCSYRLRQSYALQKRDSDPLLHGLVKESETCEGVPARLEAGTSPFIRSLQQGWYVFFFPISECGRLKDNLLVYVGDALIPGDVAEWNLASDGCLIPLKTAATAAALPGTVRKPPGCTTTAPASKSSSKTQQRWKSLFYYVVSPVPVHWGTRESTDVHLTISWRSTPAVYPVHRPKKKHLTLLYSYYCSPRAPDIFTCKAQFPSDTRLRLVSSPNCDTKVQLRSDVTEHSANVRVETMDGKPLELHRHTRDYTFVLQFFFGSDLGILEDTSIFAAAVVATVFLLLLWLLLTKDLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S8Q4</accession>
    <name>A0A088S8Q4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein kinase, putative</fullName>
            <ecNumber evidence="10">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_205140</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
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    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN98006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_010700411.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22574726"/>
    <dbReference type="KEGG" id="lpan:LPMP_205140"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200058100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_205140"/>
    <dbReference type="eggNOG" id="KOG0591">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267381at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="2938"/>
            <end position="3399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="446"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="619"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="745"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="935"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1049"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1599"/>
            <end position="1667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1737"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1802"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1836"/>
            <end position="1860"/>
        </location>
    </feature>
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        <location>
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    <feature type="region of interest" description="Disordered" evidence="8">
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    </feature>
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        <location>
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            <end position="1823"/>
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        <location>
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            <end position="1852"/>
        </location>
    </feature>
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        <location>
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        </location>
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    <feature type="binding site" evidence="7">
        <location>
            <position position="2967"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
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    </evidence>
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        <source>
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        <source>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="AIN98006.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="3540" mass="373461" checksum="D4BD2A059AB4EF80" modified="2014-11-26" version="1">MQGDSVKVGSSSQSPKGNATCATEETLKSLTAEQAVMNSNGSTVQAGSVPHLVKNVTVVAAITTAAESASPMQSPSPSLGTSSAKSEPGGTSVLACNNNWQKWGSVRPVSLCGAVATAVSSPPPPTAAAAEPFAAPSAKPLTPPTRAPLALPGSLLPFTLSVVAPVSGSSAAAEVNMAPAVETLLEKRSERSTDKATISVLCPTNRGSVAFYHDLYRRRNSNLGVSCASSAPLLLSTTSPLAMPLGCNSKWSDDSAAVATDVMSPLSLLFSRHGSDTRSPPLLTSQIGVSVPFIGEVGAPFVPPATSPQESATPQQPQQQQPPADVIARLKPSLLLMAQALCSCPFAEVMCPVLIVENSGTHIAAATTINAAPANSPAANQISTPTAYTTTEDANSRAHQRTLPLSLGLPPYHWTSSGSPHHADFPQPQVESTTVFDIQENKMTEGCRGTHHQSTAAVASGDVSDVSADDEGNPETNSTHASNIPGSISQALIDRVPLSSYSDIANATTTAAIVTGNLTPAHSAFRQEQLTSDSATPPPPRAWPLVYANDAAVSMLGYSDVEEVTAGTFDNLFSCFALTLPPNASSGSNSPFVTAAATDLASVPIALASLLTITSSSSSRAAHREAKEMNSNDEGDEKGPKKHEQSSSNALRQPGWREVKTPDELLALSHYNYIILYCERTSAYYAALAVPSYQPKISQRTSMEGKRTLSSPPLTAASAIMPAAIPLATNAKRSLMGSLSTTWRQSLRSTTQHTQPHLPAPKKLLHPSADGPSSRLTDSEEVTAVEQCERRPPMSLAAASTSPPLWPNLSSGTSPSPIQQQQQQQRHSRYVKIYILQRLESSNRAAGDAKLPGVRPITTFLDRRLTAVFELPPTEAPHVRSSQPLPPSPQRSPCLPLPDAATPTARVNPFGTGTPHALREQYVSRSQQAFLLPVAQTRRPLPNSSAERSINRTASRTSGYPGSPAPGVRLAFGSSETPSSNSDGASAMQSTSQHTNQNSLFDLSYPLFHINLAQPTSASLDCLYGASEPACAALLAATVAGGAREQPFAQPYKPEEAPHHHLSSLLSQKTTPNARQPPPKQRYLLSRQRQQRSPVSLYDKDATRTVAQFTGSAITDLESLSPMRQPASGRVSQKCNLLSAPLSAANATIALLNGTRSRTFCPLYQPLCSPDSGCASLSESPHLQSTVVSTTALIPAVARSAPWCATQEVHSEETVVELAQQARDAQKHRHKSRSAQVAALVGVATPSAWARRGSHRLSPFSVSPLNSYASPMYHSLNCGGHLSPVGGGDAADFGGQSPPQRALPGAMTGARHQQQPSSWVNSMETSVTQQLGNAPGAPWQRCNEVDHIMTHKLADRLLSQRSIVAVLVSPRLPQTIIFNSFAFMMFVQHVLRFQYRCGVTQVACILNMRLKTQLVIDIVPVEVLMRTSGCIKSSGTESGSCSTSPASHNVSVSWRGTHVNADGGDRSLITTVEAGAAGRNLAAALPSASKAQPSAPVLVNSLPSSKSTTSPQQQKILELLELRLKDLNDLLSYEESREALSPAIPTLDSSFCDLLASRSSSSSGPFTNSCSRVIPTIATVTTTAASSLDTGVTVSSLPWDPLQSLSGGSKENRSATPLRGLQSSRASHAAPCQPRHGPLRHSAPWPYNSHPEQEQQQAKNPPLSPNSPIAEVQRIAVTSHAAATMAATVPAVVSAGCSVQPNGHFETLGVAAAQVADGDWMKSVALSRPSSLAATMNSGTADVAREDNNSSSVTSSTSETSHTPDPAFSEAQALEVQQNTAEEGDDALSQQHASIEEAKGCNGVVESATENSSRSLPSNRTSSGKQSLLWAYSGVGSASKTAQQHHPHRRPPHNVPSSDYLSRDVQESLAMCDGAIHIRADTYEAQVQIPFTTPQRLELLSQLGNVQLSKYRGLSVFGANLVNMVTEEAAAEAAQPSPQIIPLRYDIAARPYLEGVRGRSVVISPLASPTNVSQSSLSKLTRASANGSATETNPTRAEVALASKGSGTAVVMEAAENASVTNTSAEASALAAGLVASIALPLRPPALQASASIPFAAAASSGSAKSHGWTVTSSKDASPEHTSAPSMGNSSSATATPSTVVPVTSVVTNEMMSSLSTRSRGERATVSVGAVSLRLSQLVAANTSSFSFTQHGSTSSSEGNFPAADMLSVASTEVLPKAEGVAATPQRGSAAAASGAATLSQHHADPLQLLMDLSPTAGTHHSTYRRSSILSMATADDRGDEHFPHTIVEAAARGDAMRGMEDGKRRLSGSVGKCTEHPNEGDTLRAAAASFSDLTVSGTSLPKKGRGLQLPAVLLACTTATAEGKQKSTAAVMKTEKERLTVHSGTNTQMASMEVTPQLRQSSTDTTAVSETRTTPNTAGVMTTVVVCSPPQRRHPQVNLTPHSRHHTIESSTQTAVSQSPVTSSQELQQTPLHVEPSMGQSWSAGSESPPVSQSSNILSASCAIRESSTSVTAKGWAERTMRGSLSGTPSAQEQLSVSHPILSCTTPLAVGNSSHTDLISTRSSETQGLFSVCTQKSGVTELLGYTLSSSAAAAFGDFSTALEKESDEHEEDSAAACSMGDKEVAKKTGASAAVLRPLTTKAPDAELCIQQYSCSGSLSAEVPKSVMVTGTLTHVALPSTLSTTLTDTAAAQPTSPEAKPAGLSSDKGGHRSSDSSGSVATLAAARVGLGAGGDWHASSGVGDNSSLRDEVDDSFADSFMDIFGLVSRPQQLKDLRHRVSTQLRSVCDRGFMSTGTTAAVVAAPAAEDPNPGAHAAMRDVWGEEEAADPTTRNNLHVLVYATRAYPEVEEVLGIYGHCATFATSAAKMLRYARSGIQLFDVVIVEWTDSLISAEIHELLVKHAVEATVVAFFISTRPDVHAPAMNTDNVMTEEMVVMHADNLLEGLLSRSVLEEVQQLIRRRQLMHSMISVRKDQSFQIHSHIGSGAFGDVFEVMMYVSRGKLAMKRIFLKSMKLRQLEIINREVSIMRALEHPNIVSFSHTRLEDNAYSIFMELCDGTLADHLLEPSVAIPGAAERQQNRSDSGAGLMAEYPGNARCASTVFSNNNSISGSCTDGKGDVPGVLQTAACVDDRADSPGSDETSITAPELTRPQDAVMIVHDIASALSYLHRRGIVHRDIKPANVLFSNGMAKLGDFGSAAKMTESRKLHNMRGTVSYMAPEIVLGEPYTESCDLWSFGCLIASIMGINLGHLNGLHMPALNELYRTIPRTGSLPLTFTNRLSLHIANHYTEATTNRVLTAFKRALEVDTAERQQGASPKSHSSVNTIDTTETKNAQNSSQQSTSIDYRALRRTDTTSTTSEEKSRYFTESEGTGSDTAAADMRNRSRRTLCITMSSIDVMGESYALLPASLVELFNRLFHRDPTERMTAAEVLDHQVSWDVEWMARMMREVYNVSCQLTQSNAEVQGTAGGASQCHVVKQTHGGRPPPGEEGARTGAATPSVTTGDFACFPIQSGSGEPVWMAGGSGGRRIPGAVGTGSGAHIPSVAQNYVLDLSLSGNSSCGSNDSRERGSDDEVADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SAS3</accession>
    <name>A0A088SAS3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Helicase-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_241030</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699443.1">
        <property type="nucleotide sequence ID" value="XM_010701141.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22575512"/>
    <dbReference type="KEGG" id="lpan:LPMP_241030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240016300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_241030"/>
    <dbReference type="eggNOG" id="KOG1016">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2020972at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18007">
        <property type="entry name" value="DEXHc_ATRX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044574">
        <property type="entry name" value="ARIP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797:SF1">
        <property type="entry name" value="HELICASE ARIP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797">
        <property type="entry name" value="RAD54-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="292"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="847"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="684"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1176"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1257"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1298"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="695"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="721"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="749"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN98736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1317" mass="145353" checksum="5D4D7C89A55021C1" modified="2014-11-26" version="1">MANGSEEVFFIASSSSSDDGDDSRRSTGVTRGARRSSADDASPQGSHLMTTGMYGECWRSPYDATPTSPTMEDVLFERASPKPRLAPQQQHSPSATLTNGVSDGTSVKIKSDAELGLKGTVAAQRNTPGAKPGADQEDEEAVPYAGGSPCAMPATQLTPPPRTLAELRSMTSADVREELERFFARKDAHARRFKSVETALFGVAPKEGCAPSTSQPTREELLARDRCRRLVNVSNWDCAVCGYNQWDVLLPSALLRNCAVAPTATTLCAPHTLRPHQVEGIRFLWSVLAEGPVGQVPAVGCILAHTMGLGKTAQVIVFLHLFMVSFPRYHERISSPSRRCSGLNDLTAASIGATAASSSSSLSQRRARALIVVPKSTQSGWKREFRTWSACFPEEHRLHPISIHEGLPARQRVDVFHAWRRDGGVLLIGYEALVRLLRLVEADSMQRPHPCVDDSDAGVDGDAGRNGTAQPTAHAFHLVNRTATMSSQQQHRNDEGGVTFGGTADPFTELVVCDEAHRLKSVNLHVVTALRGLHPLRRLLLTGTPLQNHLQEYWAMIDFCVHRYFSRKRFQEYFIHPIEASANTRASVEVVDVARKKTFTLINEVRHFVQRVDSTPLRSELPPLHEYIVVVPPSPLQKELYLRFIQIVQHDGSEKVQFLPAVSCSGKIAAHPQLLYQMSDRFREAEHSPTTSSARGGGASGRGGRGVQRDARSRHIAGAKRSSNGSGDDWAVTTTGRDWRPPQQHRRQRQEAEKRMDGMAEHAVGDHKDNTRVGEQEAVVITDSDADSTSSSSRNDGGDEERVFARATHQSFSSVYPATSLTYEELCVPPSPNYTPLLEDGVKLLVAIKLVVAAMARDEKVLLFSLSTQLLTFLERMIAKVNIEWCGPVLGSQQQQYPKSPRPIRYCRLDGSHSAAQRAAMLDNFDRPDGPDLFLLSMKAGGVGITVTAATRVILVDTSFNPADDQQAIGRAYRYGQTRPVYVYRLMCYPTLEYSIFAQKLAKEWLFKTVVEESSVKRDGLSGMHLRELFSLLTKAAKVLEKPLSATRAQTLSTQEVLREDPMLAVAQAELLYAQRYEMFLEHDMNDQYGAAEEAFYHDYCRNRLFDTANDNDAEKRRSEEQQQRRQQRIDEAAQLQVQSKTLMSMVDDIIRSRAGTDPQLARLLTAMGLHVDPITGRVQSRRDGANPRDSISNGDDRRHAAATLRPEDNGERFAPSPVQLIGGTDPYQVSQGQYHGRDAYTAHSTTQTAVLLLDSDEDSGDVPAQPHRHKAHTGAAIPSVSNAELISSSLARQPYALYRPGSSPAHAVDVDSDRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SBE8</accession>
    <name>A0A088SBE8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_251280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN98991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699698.1">
        <property type="nucleotide sequence ID" value="XM_010701396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SBE8"/>
    <dbReference type="GeneID" id="22575776"/>
    <dbReference type="KEGG" id="lpan:LPMP_251280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250018500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_251280"/>
    <dbReference type="eggNOG" id="ENOG502SB06">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273666at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="197"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="258"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="443"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="351"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="470"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="499" mass="53781" checksum="E349672442A720AB" modified="2014-11-26" version="1">MWSIFSQDFSDFAEAFKSESARFIDYVEQIAFNVVGRGDIYAGDEILGKAVTEMPLSNSLLRRLQDTEATYALLIQPEEKAAFDAWVKGSPLSSANAHHRQQNMAAGSPTSKPEGGSPAATPEQLSPLGKMPDRRSAEYPDEPISETRKRLLDYNEVVLQWYMLLVGDAVSPRFSVSGSPVAKRLQMDPPFALKFGEGEGKSPVSAVTSGEQPRVSSPSSALTPKHGRIDEDEFFDRYFFRLAQLRVLESQRRRAALARKTSGGTSAAVSQMPPTSPTTPSPSPLANDRSPQSADERDFAVVPLFAKRMMTATSDFVTGIDNALNSGVEGEVADEFSGDEANVSPTDLVHYRSARRQVADLESMVQELQEALRQERRRVEQLTSALEEQGIEVPARLMAPAPFSAAATPAKKAEMTLVTVPTPAPQIDLVLASPYDTAAAASSISGGAPATPLVAIPETPPLDNEKARGDTSSAQSTSGDMISAVIEDETWVCITPGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SCG1</accession>
    <name>A0A088SCG1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_270110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700098.1">
        <property type="nucleotide sequence ID" value="XM_010701796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SCG1"/>
    <dbReference type="GeneID" id="22576187"/>
    <dbReference type="KEGG" id="lpan:LPMP_270110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270006500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_270110"/>
    <dbReference type="eggNOG" id="ENOG502S6M3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="274898at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="85" mass="9222" checksum="52F444449D84F158" modified="2014-11-26" version="1">MLRLTTARFYQSVTAPLGKGCVMPMKFNCLKPAYVPKSFTTQFFVLGTWSISNMMANFVFGALIIAAANGGLSGAWPPDPHSLHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SCG6</accession>
    <name>A0A088SCG6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_270160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700103.1">
        <property type="nucleotide sequence ID" value="XM_010701801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SCG6"/>
    <dbReference type="GeneID" id="22576192"/>
    <dbReference type="KEGG" id="lpan:LPMP_270160"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270007100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_270160"/>
    <dbReference type="eggNOG" id="ENOG502RTRE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF275">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="261" mass="29976" checksum="40B7FD1444C0B543" modified="2014-11-26" version="1">MNTSFGGAFARGIFAEREIGYGREVMNLPAYCMHICEHDLQPLREQVLIMTKEIFSKVVYGTPQDQQYVKHRILSLMSGGFSYFTRERDVFDFADEVRAPGPDGAFRNGSNCLMSGEFSSYDLQKLPLIVEFNRFEVDYRGRRGICLFPEASYLNHSCEPNVELSVTYNSIKNNFFLSARAVRPIREGEELFINYMPGNNLPLSRLALAMKKRWGFECSCVKCKSRAVGAVTVVFVVLLIPIMVYIRRFIVERTKEKHRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SCH9</accession>
    <name>A0A088SCH9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TATA-binding protein interacting (TIP20) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_270300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAND family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700118.1">
        <property type="nucleotide sequence ID" value="XM_010701816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SCH9"/>
    <dbReference type="GeneID" id="22576206"/>
    <dbReference type="KEGG" id="lpan:LPMP_270300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270008500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_270300"/>
    <dbReference type="eggNOG" id="ENOG502S2W6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6260732at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010265">
        <property type="term" value="P:SCF complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039852">
        <property type="entry name" value="CAND1/CAND2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013932">
        <property type="entry name" value="TATA-bd_TIP120"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12696">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08623">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="TATA-binding protein interacting (TIP20)" evidence="4">
        <location>
            <begin position="1049"/>
            <end position="1173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN99411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1228" mass="134092" checksum="91AD75918917C09B" modified="2014-11-26" version="1">MAPFSTECFLRDIKHADKDLRLMALFDLRRCLPSADENGITSDVVNKVLLCLSPEERCEEVQNEAANVLPEMVVKCSQRDVIFQFLLSSITERCILNDSDDTNLQYLSGMTFKNCCLEFASEARRSVAFWQKQIDMVRHLCVGCATQLEIDGLQDTAREILYTAVNTLVPAYKEALGERDVLIKRAVRDFQKTNSIRHASLTLIESLLALVRAATQESVVAESLKLLVTATSSEEYVAYLQLCEVEMRALRSPPMPVVQQVIDSACEHLAHVTKQNDEGDDSTEMLLEVVCSLVQIHSSGKASSWRGTFAAVKDLVTFDSYASGTEEDAYANDVGYDDDYDEYYINDNGTSNSSWKLRMWTIRVLQALVAQHDDKELGMQSLSVAATTLQDHVQAVQLEAVKLVRTVASRSYVHDADCVALITSCCHRLCNLIGGEDDKATMSLIKALVDIFESLADAPSFCESTVPLLLNQVRAHFSTVAASAAAVEGCRCIVESVIQARGDGESLSSETVSLAKELSALCLCGGNLSAMAACITKASDTLAQVYKATRDACVSTVLGNNYGALLENRSFPAACRAAAAESLASWAAAQGLSTLEKPAAALWRALDCDEVKLPVLRALSIMASSSESSASVPTSVLEKVAALAESGSASVRAASVDVLLRRLTAPNTPPLAAPFLQHLMTLFAPGHPLSLSSCELAEVSSLALLIAQLFQHRTEKAVPFYGTYFVGLWEHVARMADAVLWSRSLMNPALNSLTELVGTVYEHESESRLTIEDGVRQFLVSNQLHIPCICMVVRCVSAGSASAVSAFLRTISPQLVERAHLLLCVGEAGQATGLGADWSALVLDSVQSKEGELVRSCGERSFSLCMLHPGNTESILMPCGERAADGGTAGRYYYVKSIKEAATLALSRHRTVFHDAAVSKPLLFLFLQSSVGADLVELYGACTGLLSVFLFDAERSLMIADALFETEASLDTRVTCMVALRYFLSALAERSANVEIYRPTVLRALLQLHRPTDTKESTEPSLLLRSMALRLLTTVLQHSPHWLLCEATRTSIFPNLLTELREDAKLQGTFDLSGYTHRVDRGLECRKLAFESLSAVFRAARHHNVDLVEYCEAEKSVVSMLIMACSSHGSGDRESSINDTAKDLLVRFVESKPEFVFTPPQLDSLVAKLSHDIKWGASLTDSPKTTLLYTIKCLMKLSSQPVFMNHEGFQEVAEVARKSPLLAQSLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SK40</accession>
    <name>A0A088SK40_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_350220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 5"/>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702962.1">
        <property type="nucleotide sequence ID" value="XM_010704660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SK40"/>
    <dbReference type="GeneID" id="22579051"/>
    <dbReference type="KEGG" id="lpan:LPMP_350220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350007300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_350220"/>
    <dbReference type="eggNOG" id="KOG0544">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050689">
        <property type="entry name" value="FKBP-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516:SF443">
        <property type="entry name" value="FK506-BINDING PROTEIN 59-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="6">
        <location>
            <begin position="19"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO02162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="109" mass="11826" checksum="D9EEE898218F4033" modified="2014-11-26" version="1">MGVIRTVKKAGSGATPKAGQTITVHCTGYLAEGKKKFWSTHDDNKPFSFNVGVGQVVRGWDEGMSQMQLGETAELLMTADYAYGARGFSAWGIPPNATLLFEIELLKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SK72</accession>
    <name>A0A088SK72_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial ATP synthase epsilon chain, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_350650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ATPase epsilon family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703002.1">
        <property type="nucleotide sequence ID" value="XM_010704700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SK72"/>
    <dbReference type="GeneID" id="22579094"/>
    <dbReference type="KEGG" id="lpan:LPMP_350650"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350011900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_350650"/>
    <dbReference type="eggNOG" id="ENOG502S8ZZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269124at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.20">
        <property type="entry name" value="ATP synthase, F1 complex, epsilon subunit superfamily, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006721">
        <property type="entry name" value="ATP_synth_F1_esu_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036742">
        <property type="entry name" value="ATP_synth_F1_esu_sf_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04627">
        <property type="entry name" value="ATP-synt_Eps"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48690">
        <property type="entry name" value="Epsilon subunit of mitochondrial F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="73" mass="8537" checksum="5F45D50155130876" modified="2014-11-26" version="1">MFRRSLMALNWRDHGISYVKYLNVATEALHMATKDKVRARYSRYSSPNYISVKNDGTGVMEEVKKVPTFTKDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4P7</accession>
    <name>A0AC62A4P7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NADH-dependent fumarate reductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3420150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="XUY36777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="543" mass="57545" checksum="4BC5586EA8412D02" modified="2026-01-28" version="1">MVSGTHAARLVLKKGHAKPAAPGRGRPRFPGRWRGMMATARGAQRLASDEAGVPHAKPRVLRHAGRFLLRGAPGECAARSRKNGSAWGTAVQKAAGVHDSGELFEKDTFASGKGGSCQPELVRTLSDHSAEAIEWLSSFGIPLTALTQLGGASRKRCHRAPDNPDGTPLPIGFTIVRALENYIRTNLSDIVRIETNARLISLMHSKEDDAVVVQGITYATQTASGEGKIRKLQARAVILATGGFSNDHTANSLLQQYAPQLSSFPTTNGVWATGDGVKAARELGVKLVDMDKVQLHPTGLLDPKDPSNRTKYLGPEALRGSGGVLLNKNGERFVNELDLRSVVSQAIIEQNNVYPGSGGSKFAYCVLNEAAAKLFGKNFLGFYWHRLGLFEKVEDVAGLAKLIGCPEENVTATLKEYKELSSKKLHACPLTNKNVFPCTLGTEGPYYVAFVTPSIHYTMGGCLISPSAEMQTIDDTGVTPVRRPILGLFGAGEVTGGVHGGNRLGGNSLLECVVFGRIAGARAAAILQEGGAGLPLQGGGQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4U6</accession>
    <name>A0AC62A4U6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RNA-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3420340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="XUY36798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="221" mass="24353" checksum="42B45B5CE1571FC0" modified="2026-01-28" version="1">MSSDGAAAASSVADGETKAPAAKTAAASFVRETRNIKIPHHRFPPLKKVWMEVYTPIVEQCRLEIRMNLKTRSVDLRTSPSTSPAEGDQSVAASKVMLQKAEDFVKSVIAGFDVRDAVALLRMDDVYIEGFEIKDVRANLQGDNLSRCIGRISGSHGKTKYTIENVTRTRIVVADTKIWIMGTTQNIRVARDAICDLIRGSPAAKVYTRIRAVMNRVNNAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A555</accession>
    <name>A0AC62A555_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase M20/M25/M40, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3320480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="XUY36756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="472" mass="51182" checksum="D9528480A5A26E51" modified="2026-01-28" version="1">MGDCDWTVIQKAVGAEWDASIIPALSAYIEVPNQSPDFDPHWATNGLMEKAFHILIDWVKGQNLLGLSYEFMEVEGRTPFLLVEIAGTERTNNTVLMYGHMDKQPPLRPWAEGLDPHKAVMRDGKLYGRGAADDGYAIFSAITSVSVLQRHGIPHGRVVVVIEACEESGSFDLDYYMAQCKERIGNVDLMVCLDSGSLNYDQLWLTTSLRGVTGGVLNVQTLTEAMHSGVAGGVVPDTFRIARELLDRVEDSKTGTVLLPEAHCEIPDHVAKSMVSMKSVPFKQQFAMADGVSAEPGDNVELALRNFWKPSLTVTGANLPEPQIAGNVIRTLTSLKLSLRLPPLVDSGKATQAMAKLLTTNPPYGAKVWFEPEVPGDGCATPELKPWLSNALNEGSKMAYGNPLAYQGMGGAIPFISTLTKMYPQAQFIVTGVLGPKSNAHGPNEFLHVGYAKGLTLAISHVVAAHFLLAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5W0</accession>
    <name>A0AC62A5W0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">cAMP specific phosphodiesterase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1520070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="XUY37011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="939" mass="103497" checksum="06F95729E94EFA08" modified="2026-01-28" version="1">MYQPFHSPVAPFSSAAGSGHLCETVALCQSILARYRRTGTSFSTTELKAIQALRTAFPDTAQGSAANGSASQQQLTDDFLNSLDTTDIQHNLQDDIVALVEECCDCTKEPTAIFAAINECLSRVTGSRNVRTYMMNANDNILWDPVNAVAALVDNVTSLGKCAQGCNMMTIANTLYIPLRFSSELVGCVEAPSGCIPREKTAMTQLLLRIITIAVRNTINVCLKKCEVNKVEAMVNMATRLARDTLEESVLVQSIINTAKTLTESDRCSIFLVKADGSLKAHFEDGNVVVVPAGTGIAGYVAESGAVVNIPNAYEDERFNRSVDKVTGYHTRTILCLPIAFEGTIVAVAQLINKLDMVTESGQRLPRVFGQRDEELFETFSMFAAASLRNCRINETLLAEKKKGDAILDVVTVLSNTDIRDVNSIVRHVLHGAKKLLNADRSSMFLLDKERNELYSKMADSTNEIRFPCGQGIAGTVAESGVGENIMDAYADSRFNSAVDRQLGYRTQSILCEPIMLNGEVLAVVQLVNKLSDDGSVSCFTSVDRETFQVFSLFAGISINNSHLLEFAVNAGREAMNLGLHRNSISALRGLKGVNVIEVTPEEREAVMSIDFGSAYDFTSPNFNLFEVRERCSEPMDAAAGVAYNLLWSTGLPEKFGCREQTLLNFILQCRRRYRRVPYHNFYHVVDVCQTLHTYLYTGKASEFLMELDCYVLLITALVHDLDHMGVNNSFYLKTDSPLGILSSASGNNSVLEVHHCSLAIEILSDPTADVFEGLGGDDVAYAYRSLIDCVLATDMAKHSDELKSFIEVVTGGFDMENEAHRRLVMQTLIKAGDVSNVTKPFETSRMWAMAVTEEFYRQGDMEKEKGVEVLPMFDRSKNTELARGQIGFIDFVAGKFFRDIVGSFFHGMQWCVDTVTSNRAKWQDILDGRRVSAVSVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A666</accession>
    <name>A0AC62A666_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amastin-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0820220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="XUY37302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="187" mass="20790" checksum="A795E9BBC66A4B78" modified="2026-01-28" version="1">MELTLALLLYAVLQLIAFLFVLVGTPIDMFRSRDEAPFGNTPCITLWGFKDKCYSGMLSQNSDDLWSPCPRRRDSFRAAQAFAIISILVYGLAALFGFIMLCRCPWLRVVCLVLNVTGAVTLCIVWASMVVAYSTLDRPCFGLRSRNNFGSGFVLLVLAWCLDIINMVFLLLPSQAKDPSGIADTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6X1</accession>
    <name>A0AC62A6X1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATPase alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0520010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009374">
        <property type="protein sequence ID" value="XUY37436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="574" mass="62616" checksum="23DAD102F4C88EF1" modified="2026-01-28" version="1">MRRFVAQHMAPAVARLASTAAASKSAAPGQKSFFKATEMIGYVHSIDGTIATLIPAPGNPGVAYNTIIMIQVSPTTFAAGLVFNLEKDGRIGIILMDNITEVQSGQKVMATGKLLYIPVGTGVLGKVVNPLGHEVPVGLFTRSRALLESEQTLGKVDAGAPNIVSRSPVNYNLLTGFKAVDTMIPIGRGQRELIVGDRQTGKTSIAVSTIINQVRINQQILSKNAVISIYVSIGQRCSNVARIHRLLRSYGALRYTTVMAATAAEPAGLQYLAPYSGVTMGEYFMNRGRHCLCVYDDLSKQAVAYRQISLLLRRPPGREAYPGDVFYLHSRLLERAAMLSPGKGGGSVTALPIVETLSNDVTAYIVTNVISITDGQIYLDTKLFTGGQRPAVNIGLSVSRVGSSAQNVAMKAVAGKLKGILAEYRKLAADSVGGSQVQTVPMIRGARFVALFNQKNPSFFMNALVSLYACLNGYLDDVKVNYAKLYEYLLVNKDLSVMYGTATNKFFYMYVQQLNYVIRFFTLSHPVLNAEVEEMLKQHTHLFLQHYQSKMNAIKTEKEIKALKNLLYSCKRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHC6</accession>
    <name>A0A088RHC6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pseudouridine synthase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_030480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009372">
        <property type="protein sequence ID" value="AIN95283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700991.1">
        <property type="nucleotide sequence ID" value="XM_010702689.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22571914"/>
    <dbReference type="KEGG" id="lpan:LPMP_030480"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_030009300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_030480"/>
    <dbReference type="eggNOG" id="ENOG502RRES">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="447290at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.20">
        <property type="entry name" value="TruD, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042214">
        <property type="entry name" value="TruD_catalytic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326:SF23">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1408"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1886"/>
            <end position="1934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1436"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1910"/>
            <end position="1921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2071" mass="223636" checksum="42B64D1B7D38EA7E" modified="2014-11-26" version="1">MFASSLRPTTSTTTRTPETVVDPRAALHAKALHQTAVSTRGRDGLTHVQLEQIDRRRSKPSLSEVEFDVGMTERLLPELPRLPALHEVHYGDAVVQELDRSTYFARRRHDSTRIATPSMMNASSSHPSADLAATPNDPAMIVINGETCVELSLDEDLGETSFAVFDAEAAEAAPATSDAPAPAPISAVAAASEPASSTAGGEQCVAANGDGGREKHDAAAVVCMGEAVDASDAPTPGNNSEDNNDTDEDGLSLPLNFGAERPWFVPASGVVQLHPLSSQDCALLLRFVLYLRQQTEANLVPSLRRALIDAEHQTTGTGVDGEKYAKGGDASATFEPPSPSSSIAADTSSRVRSSHLTLADVVRYLDTAPPPVIAFTESLPANRASPCATRPPPGSISPAFVFHLYLENISSQNALGHLAGLFGIPQRAFLTHTAASKMSCSTVLCAVAENRVRREHLLHLNTLRHPGFVMRVSDIREVDEDVCGSSDRSTGRNTSSSSSARLFVELARWQPLYHVEVLIRRVGSARSTANGAGLSTRQQIEHRLRAVQRVGAICFCANREASLARAATDVLHGFFRSALLNALQRQKAPVPLTRFLKRPNVATAQHAHHVSTDVTVRQVLKAFMQCNGDWQETVVRTPYVWRRRWINALRGLVWNTMASQRIRKAGREVCLGDIVLKPAYRDDVHRRGIMTVKAEHVMVVTTSAEAQAACMEDVFIPFLRGRYPEHLFADESTGHPIMTRRSMLALLRAMHAPQLLLGFTDEVRLLLDIRADVSPMLFRRLLGRPVEFEFAIMEDKPPMHALHFDAARLLTNDRWLAADGVKRLQSQPSSEIGIKDANSGNGNAPRVAALQQTRAGHLMPPSVVLEHTTLGARLASGILSEEFFSVPSADDYVVLGHAHRHLDGGLVHAAPHSDTADVGDRVYSVYIRAVVEHNLAGLSNMLREYFVLSGIETEADSSLQHKVHRMRRELDPETEVLTAPVYCSTCYNRDHDTQEQCAEYQYKRHRCGVQLDLAAAALHLGEEAQVGGTVRGDAVLPGVAGTLEDGHRGLARDEAAATDETLLMSPAKSMATTAAATTLAVAPMRTARTVCMRWRLRRRHDEQRWGVRLTKALHLVDIEDASLVREAAVWCSEAGDAGTSASTAAVAMPNEAEACPWPSSWISQSATLDEQTPPSSSSALRILRYLRAALHGSVNADTDAAPQQRDALAELLEHSPLIRLPPAASAAALPPSTETPATSQLRACKWRLTKVNAKPVTTQRDVAAVLLTEATKSREVWLTFEISIGTTTEGSDADVLTHAKPGASGSMGALSKCNNAVSTVQRGAVLQSTSAMPPEQRQEAEAAMRRALSGVSPDTRKWVQDLPHRVTVVLKKHRRDVQAHRSWGLQLDGSDMTLVNFAKLMSQFMTSSDARGKQGQGGGHSSVASIAPGNAFPRLHSSSSDNNNNERQSQRASKLLSDADPALRHLLNDMYRVVRIHNTPVRHKVEAARAMANFQASLDAVLPSADVVGQSSQLYSSNHLGAHANTSTSSEQLFLTLTLERKATSYRLCNSLATEQGLEPACAELNSCSDAPPSAAFPSPAAAAVVDAALLSGLATEHCPVRPITEVQLSRSVATVAINRLLLTSATMKKWGLRLQKGTRRLKAIQENEHFSFHVFASKKSQGTRIADTLRLLPSATAAATGATTRRAHHLYYVERVNRTAVRSHAELRQALQISTQQLTHQQQLGRGFTPLPALPPESVTLSVRQFPLLRLSATVRRGGVGEESALGPVGIQVDKRMQVVAVFAGSPMARALDEAAGPICSVRRLIRDRSDASCVMDNTPQVGSEAWWCAVQDVRLRQQLASVAAALSALSGSSAGGSAGDNDAEEVCMAVTGTTKAKKSVKRQWNYGMDEDDGDNGGGSDDAPEAHVTAATTEASPSAPVRQVPALSPSPAEDKSALRTILRDLAATAAHVQQQFCMCTMVDGVHMLQASVLQEFALAQLAKLEQHRGCTSSGTASSDDAAEAMVMLEAPGTELLQLQERLTAVHHEVRWEAVYAVESNRPLRTPADLAAAFAPGVAEETIILQQMIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHD0</accession>
    <name>A0A088RHD0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CHCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_040630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="AIN95387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703709.1">
        <property type="nucleotide sequence ID" value="XM_010705407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHD0"/>
    <dbReference type="GeneID" id="22572022"/>
    <dbReference type="KEGG" id="lpan:LPMP_040630"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040015000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_040630"/>
    <dbReference type="eggNOG" id="ENOG502S51Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1106148at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055304">
        <property type="entry name" value="CHCHD2/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13523:SF2">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13523">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2/NUR77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="16583" checksum="0CFDFB3379444E3C" modified="2014-11-26" version="1">MARSRAAPRTSGGSSRHASAAAPHPPPKAAAPLHQSTPHPQAQAHPQQPNGVTNIYVQRPMAGGGGSGILGTMAAVAGGSVLGHGISNYLYGHNNQAPTQPAEAQQLAQAAQQEGYACTPQLLGYSKCLEANPESADGCKWAWDYFTQCQSEHPMPPPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHH2</accession>
    <name>A0A088RHH2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_040060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="AIN95333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703655.1">
        <property type="nucleotide sequence ID" value="XM_010705353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHH2"/>
    <dbReference type="GeneID" id="22571965"/>
    <dbReference type="KEGG" id="lpan:LPMP_040060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040006300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_040060"/>
    <dbReference type="eggNOG" id="ENOG502S5K3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277723at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN95333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="17933" checksum="1D880B779920823E" modified="2014-11-26" version="1">MAQWIPKTAWTVSNLNKRYGVQYVTKGYASLDPKCNLDAYTSLQHTVTSSYLKKALLSISCTSPGALVIDVRSEPERRLRPLMFSAIVALHPHDILSGAACPILPSNKEKAEIFVMASEAQRAVNTCTALRRWGFSSVSAVSVDAVSAVIAVAQKSAGTATTSSTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJ45</accession>
    <name>A0A088RJ45_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Elongation factor-1 gamma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">EF1G</name>
        <name evidence="8" type="ORF">LPMP_090970</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN96012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704334.1">
        <property type="nucleotide sequence ID" value="XM_010706032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJ45"/>
    <dbReference type="GeneID" id="22572667"/>
    <dbReference type="KEGG" id="lpan:LPMP_090970"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090014200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_090970"/>
    <dbReference type="eggNOG" id="KOG0867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270150at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03181">
        <property type="entry name" value="GST_C_EF1Bgamma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03044">
        <property type="entry name" value="GST_N_EF1Bgamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000006">
        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1010:FF:000001">
        <property type="entry name" value="Elongation factor 1-gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000148">
        <property type="entry name" value="Elongation factor 1B gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1010">
        <property type="entry name" value="Translation elongation factor EF1B, gamma chain, conserved domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050802">
        <property type="entry name" value="EF-GSTs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001662">
        <property type="entry name" value="EF1B_G_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036433">
        <property type="entry name" value="EF1B_G_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986:SF9">
        <property type="entry name" value="FACTOR 1 GAMMA, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00647">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01183">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89942">
        <property type="entry name" value="eEF1-gamma domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50040">
        <property type="entry name" value="EF1G_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3 8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="6">
        <location>
            <begin position="3"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="7">
        <location>
            <begin position="90"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="EF-1-gamma C-terminal" evidence="5">
        <location>
            <begin position="247"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="213"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN96012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="403" mass="46358" checksum="996E575311ADE2E4" modified="2014-11-26" version="1">MPYVLFSSSHPENARSQKIMVAAAYANVNVELKVCQYGQENETPEFARNCSPCMRFPSLQTEEGYIFESNAILRHVARVEKSGAKLYGATPFESSQVDMWLDFAASEIDAHNMPYLRESFAGIPAPESAMATLEESLAGLELWLETRTFLVGERMTVADISVAFALQWVYRMNAKHGEELTKKYRNAYRLYNTVMQQPKTVEVLKQWGATFGPAKAPKKAAEPKPKVEKKPKEEAEDEEQPVKEEKKPNPLDALPPSNFVLDAYKREYSNTDTRTVAAPYFFEHYDAEGYTCFWARYKYNEENKKQFMTANLVRGWFQRMEHLRKYAFGVALIIGEDTAHELMGFWVFRGTGMPEIVNEVVDTELFEWEEIKDVQAEKEKITDYLCWEGPTIPRPVLEGRCFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJF0</accession>
    <name>A0A088RJF0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_100380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696760.1">
        <property type="nucleotide sequence ID" value="XM_010698458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJF0"/>
    <dbReference type="GeneID" id="22572774"/>
    <dbReference type="KEGG" id="lpan:LPMP_100380"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100009200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_100380"/>
    <dbReference type="eggNOG" id="ENOG502SNKI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="96"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN96107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="160" mass="18159" checksum="46187DFC78FEC6C2" modified="2014-11-26" version="1">MPLPHGGGLAAVLVISVGTILFFGGSFLYEWYTQRSEEQAKEAETGYYRLPPPKDCSRVCARAIEEDRLEQSLEGESSVKLPDAYSNSHRSRRGMCVCCFEKRQRFMFVLCRHICLCEPCLIQAARNYEETVLFGLFDGPVKMPCPVCRRVGYVVKIYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJZ1</accession>
    <name>A0A088RJZ1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA-editing substrate-binding complex 5 protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_100510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696773.1">
        <property type="nucleotide sequence ID" value="XM_010698471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJZ1"/>
    <dbReference type="GeneID" id="22572787"/>
    <dbReference type="KEGG" id="lpan:LPMP_100510"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100011300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_100510"/>
    <dbReference type="eggNOG" id="ENOG502QW4W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277025at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd23678">
        <property type="entry name" value="RESC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058722">
        <property type="entry name" value="RESC5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26170">
        <property type="entry name" value="RESC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA-editing substrate-binding complex 5 protein" evidence="2">
        <location>
            <begin position="60"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="431" mass="47817" checksum="709BA7AB803693A1" modified="2014-11-26" version="1">MPRNRLVAACTAVTTRGTLQSHALGVSLSTTPRSSVALGLARPLLGIPTSRGGHHSLLLTATRRYTNVLYRLPPTQTIPTHSPSGEEVDTELFVRQVKSFFEVLRQSQLIERFYEMKSCPYYECLFTNDLFFQHYDLIIPMPKHGREHRSAEISETIRYMRGWGATGDVNHVLQDVKGGRASGGDFISTTHGILMGYGTSRTNRLSMMTLTGAVAPSEAAAEQTRALCVEPVEMLPESPPLSDVIAFAGQRTFVISDTEHGHNAAQQAVKRIPKVPWQIIKLEPGCCFFSHLAGVNYVYDVLCDQDFPLSMERLGESGMNPFPVEWSEPRKLGITMRSICMTARFARGTMNAGGYANSRGHRASSFNYHSRDIAKNSRLFVGGNRKHGDQLSPLAAQLEADEIQKPVYQPIPRYAPPMHRRGTVVPTESPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJZ8</accession>
    <name>A0A088RJZ8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC1 family protein, putative</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_100560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696778.1">
        <property type="nucleotide sequence ID" value="XM_010698476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJZ8"/>
    <dbReference type="GeneID" id="22572792"/>
    <dbReference type="KEGG" id="lpan:LPMP_100560"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100011800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_100560"/>
    <dbReference type="eggNOG" id="KOG1236">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd13971">
        <property type="entry name" value="ADCK2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044095">
        <property type="entry name" value="ADCK2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052402">
        <property type="entry name" value="ADCK_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45890:SF1">
        <property type="entry name" value="AARF DOMAIN CONTAINING KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45890">
        <property type="entry name" value="AARF DOMAIN CONTAINING KINASE 2 (PREDICTED)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="3">
        <location>
            <begin position="188"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN96125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="595" mass="67517" checksum="E7B32786DC4B58EC" modified="2014-11-26" version="1">MSGTDMRRRVTALSRRQVRIFGAVATGCCGLGLYGCYSKFFLPEYLREDQRRRMPMPVRRTKLYVAGTSMGDGLLPEVRSMPKVVFFFYVAYRVVLLFVGCVPVLWYGFLTYSLGLCPEQIFYEKMLAFLSSMGPSYIKFGQWMATRPDFFPNQMCKMLEKLYDSTEPHKWSHTEKSLRRVFTDGTCKGHNALRYISEIEKVPIKSGSIAQIHRAKLRESIDGIPAGTELALKVTHPHIREQVSADLAAMRLFVWVGNRIIPGLRYFNLDASISEFSSLVRSQLNLLVEADNLMQFRYNFRSFNGVIFPTPLMSLSTEDVLFETFEEGVPLHNVMYSEEYRGVAELGCHMFFKMLFEDNFVHSDLHPGNVFLRTNKTDGVRQYYPDGKRKLRFEVVVLDTGLVTTLSRDERNNFISLFAAVACGDGELGADLMIDRLPHSMRDAQDPVNRERFKQQMKQVFDLVSPEAAGFRLSKVQIGTVLGKIMETVRENHIPLDGNFASLVLSVIVGEGLGRKLLPDFNIFAEAAPYLIAFLEDGELFFLANKLQGTYGATALLRDSVDIVRPSKVGTYAEMAVKKGEHMVQKFFTSDKAHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RK28</accession>
    <name>A0A088RK28_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">AAT20</name>
        <name evidence="8" type="ORF">LPMP_100660</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696788.1">
        <property type="nucleotide sequence ID" value="XM_010698486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RK28"/>
    <dbReference type="GeneID" id="22572802"/>
    <dbReference type="KEGG" id="lpan:LPMP_100660"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100013200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_100660"/>
    <dbReference type="eggNOG" id="KOG1304">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276116at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF349">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="78"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN96135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="483" mass="53182" checksum="60C41ACA7369D964" modified="2014-11-26" version="1">MNAASEKEPAHPAPMEDERHNNTLVKGFVNMSTVEIVGNANNDDSSPEQGTQKVQEYVEMDEEDVPTGSLAAGELKENTNIYKSAFHIFKANVGTGVFLLPTFYPDAGYVVSVILAIFISAAVLDCTLLLLNVKVTINRGDVTTYSQVCRYVCGVGLGWFLFVAMCLAQFGFCLMYSQLFGETMNELVTFSGSKYVWVSLMLIINFPMTCFSDNLSLLAIASIIATVSVFYSLICCFVASIMQLSQAGVHPGCNVAGDRIPVGWFNNLANNMMVLEGIAIVLPVHAACTKKRLVPMMVTIVLIGVVSWYVLFGLTGYLAYGDSMTTSLVAKMEPSPWGTSVRVFFALNLVFTYPVQFMSAMQLIDQTVKCRPRSWLGLGLRLLVNLIIWALAMAMPTSAVNTVVAFVGALPSVCMVMIIPSILAMQVNYAVDHPDENRNKLQYWKKIFVSTPCFTFKRLRCYVYLVSALLIMVIGTYSIAEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKG9</accession>
    <name>A0A088RKG9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Subtilisin-like serine peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_130940</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697175.1">
        <property type="nucleotide sequence ID" value="XM_010698873.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22573204"/>
    <dbReference type="KEGG" id="lpan:LPMP_130940"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130013700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_130940"/>
    <dbReference type="eggNOG" id="KOG4266">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1740355at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839016" evidence="8">
        <location>
            <begin position="29"/>
            <end position="1785"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1735"/>
            <end position="1753"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="9">
        <location>
            <begin position="88"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="576"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="792"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="848"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1127"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="872"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1129"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN96522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1785" mass="190584" checksum="1C79EB7589C921E9" modified="2014-11-26" version="1">MKAAVALRLPTAHPLVAFLLVLVAFHVAEEPWPLTVQAARRPTEKRAHEPGTYPRDYYLGEYGARCVGNVTGAVTPDDAAERLACFSGRGVRVALLDTGLCAGITERSRNSVTCTSVVPGVACEDAGCAHGTRSVSVLAGQLSVSPPLDREPPEETAWRHSGRHIVSAGQYIGLAPGATVRVFRVFDRQGRTHQRYLARALGVLLREAEDSEAGRLNRTWDTPSAHIRRRDETVDVINLSYGSEDYYSNSQVQSKLYRLMHEHGVVVVAASGNDGVRFGSVRSPADMPGVLAVGALRVEGHGRTAQTSRTLDTNAQGNPAAGALGDLADSFAAGGGHKSVAHFSGRGPTTWELPFGAGRVKPDLVALGQHVWTVQGVSAAAFSTAAPRRRRAAPALQLRSVSGTSIAAPIVAGVVALCLEAAWSSASAAVSMKNITGDGAYLDVRHNRLARVSDSLLVREAILRTAIPLEDTAASLPSWPYSAPVTPSHNDSSSTTSAKHPRRRVLAGVPLLQLYARYLHLSRVSILSQGAGEVQPLRALHAIVARSLASSASNEPDALRSCTSFAIPPSVRMGCGISSSSRSRSSIPQSCQASHDPDGKAHGGAPLQGLAGTSLAAYWWPFSDQLVYPGATPVLLNLSLHLCPSSSPESTDHGAHVAATAAASGRAARLESRARYTHVTYVLTKVSGYVRTREGPPSEHRSYDHGARPLLLFLQDAQSHHRVRHTSFTRIPNSTAWNASHRASSSTEGIVEGTEATVMGPRHTRADVRSSAKRRSAQQRWLQHLLRVETELTPVAHRSPTRPSVGKQQPQPLSPPPTSFSLSVAISSPSSASTRLCYDVARETVTMWRKKSEKSPDTEKGTTAGRSSADGDDSHDKQHTRDGTQIPEDHGSCVPLFHLFRALDVEGALHIFTGGSASQLTLAVPFTVRVVEPPPRVQRVLIDTSLDWFNPTTASSSLFIAGDDPHESAAGGVGAARRRGQHRQSHERAYAEAAGGDHPYTNLVLLWLYLRHTLGMAVETFPLLHTSTMTTPIAAGSSSAFSSSATRAFKDSHIAQRALADALAHVGTLIIIDPERPLTRDMRRLLTHAVLGGGANHSADGLNVLLVTDWYSTDMAAQLYWTRNESLGEAERSSRRSDTDAAEEATGVGGDRDTVRSMRAYRQLKNGTTRGLAGTSHVPSWNRWLWEVMVASGSTAHSSGCNHATNVSSKELFDGPPELPFELSETIVIDGVLVVNAAAPTWESGPETNATATYDGGTATLAKAVAVRSLGQLKAAGVLQWRLPTQPSGQQLAGGVAGTGALKGLHETSPQPGVNDTCRTSYVVNIPAVPSTQEGEAVICNVMPSWAQQQRRLVKRTILSTGNGSVPASAQSGSAAGGGATVVEDDWEELSGTYRERGQGHIGRLAAVEIGTSPPASTDAGKDTQRLTHGVLGFLTPPPPSTRVATVSTSRFRPGRIAIFTDSDCLSASDYNVQTALDELEVILYPPSASSSSPAAVCATWDCFARSPDGQRLLQAESTQSSVCVEVVKELLLWTHTGNLHHWRDSAQLQCEERTWARAVHRPSADTTIPSTATALEVEAGLDSVDGGRETTSFDELLETAPERAHVGEAVWRLWAALVKNTAHDASPLDVCDTEDGAHFQRDYASDQASAAAEVIRTLMMNYHGDWHVHLLDNNVVSPATGATGNLYLQPPRIPSSQRRGLAAMQLPAECTPLIESLLSLGDLLNALRWLQHPIVLGQLMVGAAVLLSVWLWRALEVVVRGRGDGEANVQGCPLLSSSTATRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKH8</accession>
    <name>A0A088RKH8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_130230</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697106.1">
        <property type="nucleotide sequence ID" value="XM_010698804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKH8"/>
    <dbReference type="GeneID" id="22573133"/>
    <dbReference type="KEGG" id="lpan:LPMP_130230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290029500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_130230"/>
    <dbReference type="eggNOG" id="ENOG502S74Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264048at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000795">
        <property type="term" value="C:synaptonemal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019789">
        <property type="term" value="F:SUMO transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042123">
        <property type="entry name" value="Zip3/RNF212-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22663">
        <property type="entry name" value="RING FINGER PROTEIN NARYA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22663:SF17">
        <property type="entry name" value="RING FINGER PROTEIN NARYA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0469">Meiosis</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="7"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="137"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="211"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="330"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="87"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="164"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="336"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN96453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="413" mass="44638" checksum="A18BEAF74810AE54" modified="2014-11-26" version="1">MSFQPICVLCLSDCDRGGGVTSCNHYLCSRCAARLPTAAPCPLCQRPYQLIRLDHPNVQQLLQDGATALERTEKVIGSQMRHYQQVIRRMRQALAMLHSQNQEMTRRRQQEQAECAAAVSRAQTLQAEVCRLREGLTRASSKRAASQQQPPPLPPSPPQQRAHVMPDPRVTHDSDGHPHNAPNTLGVCHTPSAQIIPPPLAVRHAPFAPTSAVGAKAPDTFSRGSWQRPSGASSPSLSSHPQWQHRRHHSHGNGGEARDAAVESAPPLGWSASSLIAKRHRADSDPSLSQGRMGDVCVSLAQPDASSNAGRNVALTPRTHALASLQHQLPHQSSRAAAWGPGSGDGSDSAGPRVDFRLTTPLAAALHQQPQPKPQPSHPLNSFMQAGTSYMLRPSLKPHQRLFSSPRDGPVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKM8</accession>
    <name>A0A088RKM8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome c1, heme protein, mitochondrial, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_070080</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </cofactor>
        <text evidence="8">Binds 1 heme c group covalently per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009376">
        <property type="protein sequence ID" value="AIN95694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704016.1">
        <property type="nucleotide sequence ID" value="XM_010705714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKM8"/>
    <dbReference type="GeneID" id="22572343"/>
    <dbReference type="KEGG" id="lpan:LPMP_070080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_070005600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_070080"/>
    <dbReference type="eggNOG" id="KOG3052">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5925at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000018">
        <property type="entry name" value="Cytochrome c1, heme protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002326">
        <property type="entry name" value="Cyt_c1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266">
        <property type="entry name" value="CYTOCHROME C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266:SF3">
        <property type="entry name" value="CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02167">
        <property type="entry name" value="Cytochrom_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00603">
        <property type="entry name" value="CYTOCHROMEC1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="8">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="8">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="8">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602326-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN95694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="258" mass="29944" checksum="F620DF4D4A7296DB" modified="2014-11-26" version="1">MAGKRAHPIKRDWYWNHNDRFEIWHSLDWPSVRRGRQIYTEVFAPCHSLGRMTFTHFQGFMTREEIRQLASQYEIIDSEPDAEGNLNRRPGKPTDTLPTPYPNQRAAQFANNGAEPPDLQHAVFGKEGGPDYIFSLVTGYNWGNGELMEIPPFAPEVKPGQFWNPYFKGCVLSMPPPLSDGLVDYEDGTPATMSQMAKDVVNFLRWSAESEYDDRRVAFWKVITTVGLVNCLLLHYGQKNTNWRIYGRTTFRYWKKAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKR9</accession>
    <name>A0A088RKR9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sel1 repeat family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_070630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sel-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009376">
        <property type="protein sequence ID" value="AIN95749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704071.1">
        <property type="nucleotide sequence ID" value="XM_010705769.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22572398"/>
    <dbReference type="KEGG" id="lpan:LPMP_070630"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_070011500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_070630"/>
    <dbReference type="eggNOG" id="KOG1550">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27934at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF147">
        <property type="entry name" value="SEL1L ADAPTOR SUBUNIT OF ERAD E3 UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1488"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="181"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="487"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="550"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="895"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1017"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="269"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="292"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="337"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="368"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="581"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1060"/>
            <end position="1079"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN95749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1512" mass="161756" checksum="DA46D907E483E1EC" modified="2014-11-26" version="1">MSIHSVLRRGCRSGQQRCSLLWRFSVTVLVLAILASVATQAVLDEVESNASEHPADTFGNETNSVVAQAPAVHINAFHVLSADDKLTPASAVPQHHDDAALGAPKSSLSQQGHYEQATKRATELHTDSVPADRKAGTSSPLPSEAFTEESVRVARDWPEQPLPQQDVPSQVPLNSTLYSGEEENWQHEQQHQATEPTASAPSLMCTDDTDVPYVGDAHAAPPATEPATVSNNHAGITAAAADAAQGWEASPPPPHEDVTTPAQPDEPSAFDKDTPSTPAWKERDSSASPQPRTEDRLPFQRDGRDPHEDQQSAALDHDARTTPQSGPGWEVTKRQQEAAAEAAHQETPPASTANAAPASPEAPTAQRTSEELHQAWAGEAHEEVGGEVSSDSPSVLEAQEQQLPEHHDEHQQWTEGGGVQGDGATHGAEATTADDGVLTGTSGGLAKEVWPAEAPLPEAELTAEEHAATAEVPETDRSVSLFATADVASDVPVSPEESGEAAAYVQATEDQVEPGDAASATDADTIRDGKGAATQFWEGPDDTAAAETGFTEGAESSVRESAADVGNADGDELNKEREGFAPSSTASAAITTPCSSTDTPYHPWEHHVLHPRSPPPSRLALSYLYYHALEALYVDENVTLFVQRARDVAPYGHARLNWLLGVLHAYGVGVPRSERDALMYYSFAAMEAVPEAHMALGYRYKLGLGVVESCESALAHYREAADAVAMTYDGTAAASDSGVTPMAAGAKTIGSGRGSRSGSTSFFAYRDDAAASDVRKQRRLDLISLKYQADIGDVDAILTLGYLLLKGDYQVARDGRRAATYFKAAAEQGSARAQGALGQLYMAGDSSITPPLRPDLRRALHHFRLGALQNDALSLNGIGFLHAIGYLHQDQRHGAADTNSHATDESDVDDKSAAPPLNGPPDFVTAAQYFYRSHCAEGLYNLGVLFLHGRGVVLDKKQARRLFERAAKQGSVLAQWQLANMLSEVAEDSRGIPAAECERALALYQRTASFGTWQHRAPGNHRSGGGAAVGSDNANVQPQRQRHGDAAKKMGINGDGDAQLLRETRDRHVSSHDGSRGQDDDGGAANHLGGFVRPRSEAEYQVLLAGILDRLHAVEESLVSSDEGEGPTTVSLASFVELLSLTETGDAVSPWVAAQYVDEYLEVADTTLPDGRHVGKAGAVPLLWPSPSTPAGTPQYLSGEAAASELLYHLLQRTVLHHTHTHATLGAAYLRLGNFYYYGESPLYGVNMERALAYYRIAGDQHHNAQALFNVGFMYQLGLHKAPRVTRVVGGMSAQEVAGRPDVLRHYTSVPTGAEWMVHSNPPEYLVASPAFYLAVKAAANAWDRTSADPMARGVDVYLSWKYYTASLRQEERGWMAVQFALLILNVQWSLRHFGISGLLPQSSAFTSPSASSSTSADSTFSLDEVGMNGVDVPLSTGVGGAHWAHQDRLAALQGPLGMLTAMLQVMWSHVKRSAVGAAKAMLSWYELLENAMLYGAIFVAVIGLLVRHHVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKZ2</accession>
    <name>A0A088RKZ2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_080400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="AIN95849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704171.1">
        <property type="nucleotide sequence ID" value="XM_010705869.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22572502"/>
    <dbReference type="KEGG" id="lpan:LPMP_080400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_080008900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_080400"/>
    <dbReference type="eggNOG" id="ENOG502SHQP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267333at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19327">
        <property type="entry name" value="GOLGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19327:SF0">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="860"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1778"/>
            <end position="1803"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="306"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="401"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="563"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1006"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="868"/>
            <end position="883"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1880" mass="203392" checksum="54BF536C9DB587DD" modified="2014-11-26" version="1">MHAATLSSLPEDESPVAPVSPPDSNATRTDAAPYPSSSTTHTAAVPSSLSTAEMSNPVASDFARLDATTIVEALLWMSGGKSSGCGWQGPAPHTVEVQADRSSTPLEASVEALKASHQPPPPLLPNSAVLPSTGNESLVCARAYAASEPNAPPAAAATVAPLQRPSSHVPSSSLAPFFQEDAAMTPCEQTPTPRRSDAAHAYRMGRRDDGEGQAHALPCTAPTAGVDSTGLVSSTFASRSSTAAVSRTSPQGGEVLSVTALQRAPSVPRQASAPAAGTDAPGAVSAPRSRAAGTEVGGALWQQAFAVHAQQLLRETQQQVDELRQYQQKAVREAQRADAVAAGYRALEVQLAEADAKRAEERVAHEAAFTELSQQALRLEEAVGVLRRSKLELQRQLKEGQIAAAQQVAEHQRELRELRSAFESHVERMCTEQHRQVDQWRQERQQLEEELAEWKSTGITMSAQQRHMEVHCAKPEHQHRADVATSLHAMSTPACEAEAERTTAVCRVDAATTTDKVNPPAAPTTPQEDNASPYARVHRDVLAQQQLREQTMLSQLSIADARVQQEAKQRRLAEDRVAELLKQSEQLREALANAEIATLNAERASEVVRKHAAAALAGQSPTKRANSNHQRRQRTIVEQDVAYQRQQLLQKIQHEYTALRRERVALVSQHKAQQQRAAERWIAVRSAVSTLLHVVGLHDAQSTLDAANDADTSSLPCIGDVFTESSETSLNGILAALDTLTSALRSQQKAAAADEAAMHEQRRLSALEEALRAAEAQNLAHIASLEATKAQLCESQRELAVWQQRQKGLATRQDAQDAAWRVTALQLKQVTGVVRRALREYAQPLPASLSMLNSARAAAAESADSARRRVVRRRSTRGLKQRSRSTPTSAALLDSAEDSEGDATVSSRGLHHEAFVPGKVPCEGNEDDDTDTIAGAKCGSPPWLLSTSTASLSFSSAATFGITELTDAGGDAGHSGVRRAMAVVSRGLLRLLTTWRTRQHTLVEAHKALQRQVEDAMAQNAALAEGQREAKSRYQQQLRLSRAAEQRRAHQLEHAQQELEDAKRQHVLDSAQARQKASEWESERDVLCRRVRVAEEQVNRAEQALVEADVAHSTQHASHETLQRELSDVTASRDRLERRQADLCVHIEDLEARLLVAERTQAALHALITTSVAFIARLSADHQQLQGHYRVLRTLAQAETQTARMVECVLERNNLRKEEQGSAAVAERRLTWSAGAPSGASAWPAAAAPHSSAPATRLRAVGHAVRAATRLSLLLAARQRLRDNAGTHDSDASFLSPAATAAESAALQPLLLALSSAFTWGAAAPVLNSAVITPHDSLLQRYTTRPDSCVLPVVRLPPPLELVALGYNEDSEVEARGEARGHKARFGCRSGAYENEAAHVSAGHQQRQLVRLLTVAQLDVQAPTTRHLCAEVVAAGSASARATAELLQLVHVRHALSEKLMGPRCQSSLSISQPQSVPPLPDLRPLLPERLAALLQWQLERTTMQACHASESNMLVQRLVQQNEKVVSALQLRTQEYDAASAKVQSLASQLEQLQAERTDRTAVQEKLVEARASLLRERQLRRAAEERLAELALTRLQWLSDQEQYKREVCLLKMELANASMGSTPPAEEGVRALLAVRGDGVVPPLIKSALSIQVGDTTMTDTACHPASPLPRLDPLSGSVMDGSAMYEPDRVHSGHPPAYRSAPLAAEVDWHLNPENVYYCKLPPNGHQHDDRSHAGRHHVGSCDMNVEAPKGNDARGMASPLPALQYRPRISLPTPQDLAESVPPDGTRSASATHGGGGGVWSIHNTGASLWNAQLQPQSSSSATALSSAALSITTRARTRGSELPPAPQPSLPSTHALQLYVPNVVRQREKGPPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLG5</accession>
    <name>A0A088RLG5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ecotin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ISP1</name>
        <name evidence="2" type="ORF">LPMP_150340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I11 (ecotin) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697411.1">
        <property type="nucleotide sequence ID" value="XM_010699109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLG5"/>
    <dbReference type="GeneID" id="22573450"/>
    <dbReference type="KEGG" id="lpan:LPMP_150340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150008400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_150340"/>
    <dbReference type="eggNOG" id="ENOG502SNN7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271632at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.550">
        <property type="entry name" value="Ecotin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036198">
        <property type="entry name" value="Ecotin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005658">
        <property type="entry name" value="Prot_inh_ecotin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35890:SF3">
        <property type="entry name" value="ECOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03974">
        <property type="entry name" value="Ecotin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49772">
        <property type="entry name" value="Ecotin, trypsin inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="147" mass="16582" checksum="D49B88BC4152979D" modified="2014-11-26" version="1">MMSCCKTEAPYPHAESDEKRIVFALDPKGDDAERDQYRLQLIPGRVSEMSRNDAANHQILSGSIEQHTVEGWGAPFFHVKLAKEAAATLMQVHSEDHVEKSRKFVALSNTPLVPYTSRYPVVVYLPKDAELRYSIWCGGEQMQATTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLM4</accession>
    <name>A0A088RLM4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Flagellar calcium-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_160880</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May contribute to the rapid motility of the trypanosomes, playing a role either in flagellar structure or in calcium metabolism. Could alternate between a GDP-bound inactive form to a calcium/GTP-bound active form.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Cilium</location>
            <location evidence="2">Flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the calflagin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN96962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697615.1">
        <property type="nucleotide sequence ID" value="XM_010699313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLM4"/>
    <dbReference type="GeneID" id="22573666"/>
    <dbReference type="KEGG" id="lpan:LPMP_160880"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160013100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_160880"/>
    <dbReference type="eggNOG" id="ENOG502RZEX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270165at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003299">
        <property type="entry name" value="Calflagin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054322">
        <property type="entry name" value="FCABP_EF-hand"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22592">
        <property type="entry name" value="FCaBP_EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01362">
        <property type="entry name" value="CALFLAGIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="7 12" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="11">
        <location>
            <begin position="39"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="11">
        <location>
            <begin position="122"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="11">
        <location>
            <begin position="159"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN96962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="203" mass="23060" checksum="AF62AB25F11E6625" modified="2014-11-26" version="1">MGCNTSKAAPKSGEDRTAAERKAAWEKIRQSLPRQRTPEDKERHVLLFKKFDNSESGKLTMEEVYQGCVDILQLDEFTTRLRDIVQRAFGKAKSMGNTADDGQESSDYVELLEFRLMLCYIYDYFELTVMFDEIDTSGNMLVSAKEFKAALPRIDEWGVAIEDPDKIFKEIDTNSTGQVTFDEFAAWATGCKLQSDADAMKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLV8</accession>
    <name>A0A088RLV8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_100740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696797.1">
        <property type="nucleotide sequence ID" value="XM_010698495.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22572811"/>
    <dbReference type="KEGG" id="lpan:LPMP_100740"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100013800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_100740"/>
    <dbReference type="eggNOG" id="ENOG502RKH2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273113at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="717"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1008"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1521"/>
            <end position="1553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1636"/>
            <end position="1677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1689"/>
            <end position="1841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="726"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1010"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1025"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1531"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1636"/>
            <end position="1645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1696"/>
            <end position="1706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1707"/>
            <end position="1717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1718"/>
            <end position="1729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1810"/>
            <end position="1830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1831"/>
            <end position="1841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1841" mass="196450" checksum="34187898AF005222" modified="2014-11-26" version="1">MAAVSGPTLDARVEDIVKVEETLASELTLPKVVQLLIDPQAEGVERITMGEYVAMQPKRQLLALGGQKEWQQWMAQSTYYQQAARLAAESPAQDLAALQQAGIQSLQQWLEHPQLVKVSARTRSALDTAVAQSVEAYMAEVVKVVNTSNQVEDILSHWVSDVMGKFVLDSLQIPIDRASQAMWTKRKEWMPADVVRNGGGSPLSSAAVLGNDITGRSPPQSIESRMLGEMLNGRGGCGAAPASTANAPQWQQPQSMLRPGEACTLDHYLRFVQKVVSSVRQDYVANHAAMGATLSNRGDDQAEREITERSYGVINAAFAQLLEQAVAHQLPPELQALQQNGYLALDRVPGLLKRAGSLLDLRSVPVRYFVFHSAVDESTTVAATASHRCLSRADTSLSGGAMSGLAVQAPLHYASGTFLTGSNQLDVTLGEWSGQPDPPSSTARESGGVVDDATEQEYLSMLHRLRRRVDTLAVTSLYEVIAQPGRFGGNGFSAAEAVGLHQLFGPVKLLEDRLTTLLHYPPAAADKPIHFIEAGPLSGKTALLEQLAERSARPGDKVVLVRYGGSATPYLPDLDDHPVAFAARFWFRVALASCPYLIRTEELYSRAPRSVYWWGHENNWSWERYQSLLQSARNAGTGHRQYQQQQQRGAPSAAVATPAQLASILVDDVDRALSAMQVKWGNAATLSSAMAISAQGGSGSVRGGAFSHLTHSSSAAARKASSTAGVDEDIDEDAEDDAGDGEDEDAPARATAMVTAAAAHSPSLEQQRQQVMSLWLSTGKSVEEHLYSCFTQISAAVGQVNFVFAGTAATPLLLAYCPAPCRRYYLPLSGGVGLQSRLRVLPLLATLHALHLTHRLDMPGLLYEVLKNAPALAGKALELFWSHRVSLMDLRTGLPRLMMGNGSAHPQLLHSYVPRELFAELPVYITLLHDPRRTRRRLVELLQRQLSSPTGYLNTELDTTPQDVKDGLVLPHNHTSSQVHPFALFVIFSRQDAIDERVFNSEGQLLEGSELQRDGDAEGKDSGSEEGSSSGANAKPKAAVANAAAAARLRSCTGVGSNERKVVRAWAEVWAEYRSVVSALSTTPARKRDAMRILLHGALLLRSAAVAGAQLELNLKVPSFGFPLLASETRVRGSSAHHPRGTAAAGNELLIRSATPDTVRRAVSAYKMFFSNAAPSHFPFRPMVGLNGGCDVVFVCGSTLALFNIVTTTAQLRHMVARFAEALLGVLHVLERQVLPADKVRSVQYVTVVSLDEARPGVEASLHGNSRSGGQPSVYARRRGSAVAGGVSVDVFNPAAAPTVPYYLDYDAVFEDHVIDRLRELQQQLGITKDFRTLSELIENIERTHRVQVLQDVVATPEEVESLFSPTLLQLVPDSTMLPAYTSAVVSATDLMVQAMSRGAGGRRSSDAAVDDDDDDADYVNIGEEDVVPGAELDDLASDTRLLRDAATGKSAAGGIGTSEHLHIADDDYMHESAALLEAMMNDEVNSMTSWSAQLQRQREETAHDLQRDLVMEDRINYNAPLPSTSVSTDGAAPAPAAPSKSPRAPGRSAAEDAEADALAWLHDVITPESLIAGLTGSSPGVPASSSSFPSTATAAPGAATYRQDTASPIAGMPLAAAGGGFASCTPFPGSMASVTGPWTPNPTASPMAASSGAETISGAHPQTASKGDGNGAGGGGASVAAGTLTATTPEEKRGAGAAAAVNVAGADERKDAKNSGEEDDDAEEDEENLSPVKPFVTEGSRRKGGSRGSSKTNTVAPQRPRRESHGSRGKRPSVASRQRRTMSTPSRDDHATARFAPQSTSQARRRKSSTSAAAPASSKKSKATPSSSSSKKKSSSSRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLW8</accession>
    <name>A0A088RLW8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ER membrane protein complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_170140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697705.1">
        <property type="nucleotide sequence ID" value="XM_010699403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLW8"/>
    <dbReference type="GeneID" id="22573757"/>
    <dbReference type="KEGG" id="lpan:LPMP_170140"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170006800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_170140"/>
    <dbReference type="eggNOG" id="KOG3060">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="124397at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039856">
        <property type="entry name" value="EMC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12760">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="317" mass="36227" checksum="FB7AD5CE6F98FF73" modified="2014-11-26" version="1">MSDSECHLSLQSLTPVDLKQLSRQQKITLVQNYRASGARNANKMLFLATDLLAGGSSGLSSSELYDVYEQVLIASLECGRIENATMYLNLLESRFGKKSVRVSHLRGLCLEAQGKIPEAKKLYEQVLKDMPTNDFCVKRLSAIYKSNGHYEEAIRVLEKDLVYTDEDDKQHTYLEVHCGDALSTYRELSNLHYLIGNIEKAIYYAEECLLLDTESYFAHVRLGELYYMKRDLPRCAIEYSQSLLFNSQQNNSRAAYGLWQVANEMLRQHHSGVKRIEEEAVLTQTQDLRTYAAETLRRMYAGTPMLSALDAYLQREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMM8</accession>
    <name>A0A088RMM8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_170570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ACBP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697748.1">
        <property type="nucleotide sequence ID" value="XM_010699446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMM8"/>
    <dbReference type="GeneID" id="22573800"/>
    <dbReference type="KEGG" id="lpan:LPMP_170570"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170011300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_170570"/>
    <dbReference type="eggNOG" id="ENOG502SJYJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF62">
        <property type="entry name" value="ACYL-COA BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="4">
        <location>
            <begin position="36"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="ACB" evidence="4">
        <location>
            <begin position="140"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="315"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="407"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="427"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="441"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN97095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="492" mass="54569" checksum="223879EF419DFC76" modified="2014-11-26" version="1">MFARFFGRRAKPELKVVCDAESIVYPVDFDAPDYPYEQAFKEADAYVRKLPIQGVIPISDIVRLQFYSLFKQATEGDIGEKDVKQPSMLRDWERYWKVYGWRKCRGMTREKARDRYIDLLDLQIRKHCSFVWGAPASEDRWAAFHDGVRIIRNLPKGGYRLPESLRAHFYALYKQAHVGDLSDFQKTPGARSGKYKWLRSRPLKAGFDQMRYDEWAALKGMSPEKAKRMYCKDIFKNAAMCGYVWAPPGTEDHLEVIGDQTSAKTLKKRADADKDAERIAAAAHLSIEETINATGVQLSMIERLTMHSFLKEEKQAAAAKAASSAARRKRQEESERKHRGAAGSHADPNTGVASARPNAEVSSSSEEGEETEADVKAEGEETLESQGTGSDFQSVCSLCGSIEKDVPTDAAAPEGEKMSGTPAVATKSGTDVSTSRAPVVKLEAPAEAKGAPKPPLLERQPTAKERPVTKGAAPSFQAKNRAKRNAAKENEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMW4</accession>
    <name>A0A088RMW4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_171020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697793.1">
        <property type="nucleotide sequence ID" value="XM_010699491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMW4"/>
    <dbReference type="GeneID" id="22573845"/>
    <dbReference type="KEGG" id="lpan:LPMP_171020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170016500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_171020"/>
    <dbReference type="eggNOG" id="ENOG502SA4G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19657at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF7">
        <property type="entry name" value="ALPHA_BETA FOLD FAMILY, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="82"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="390" mass="42610" checksum="31371FF300521C6B" modified="2014-11-26" version="1">MVESDSRLPPSETAMTSTSPGMVTVRSGKPEDIDLPQDVLDELRRIFTHHPEEVFVQVGRCASTGKDITLCYSAFGNPSDPCILLIMGMNASSLMWDGRFCCYLAAAGFYVIRYDNRDVGLSTRLDEYPSPLILQLALPAWASIGERPIAYTLEDMAEDAAGLLRALKISQAHIVGCSMGGMIAQLLTLRHPEMVSSLCLHSTSAGAPWPKPLLLLNLLDQPANTNDVHSVLDYRVRFFKAVAGDMAFHEHEFRLGMWFDFVRAPSQGGGRRHLAAIARSKDRSAALKAHINRGTNNATNSGNERSSASPLGESTVSSRHIPVVVLHGGKDPLIRLSNAQHLANCINGARLVVFPKMGHYFSKEMYQPIADEIILNARLSAVTMGKTIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMY2</accession>
    <name>A0A088RMY2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Organic solute transport protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_171220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="AIN97160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697813.1">
        <property type="nucleotide sequence ID" value="XM_010699511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMY2"/>
    <dbReference type="GeneID" id="22573865"/>
    <dbReference type="KEGG" id="lpan:LPMP_171220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_170018500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_171220"/>
    <dbReference type="eggNOG" id="KOG4033">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2157380at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019332">
        <property type="entry name" value="OSCP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21439">
        <property type="entry name" value="OXIDORED-NITRO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21439:SF0">
        <property type="entry name" value="PROTEIN OSCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10188">
        <property type="entry name" value="Oscp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="446" mass="47406" checksum="1BFE6DA92BCEE7C8" modified="2014-11-26" version="1">MSLHDMPFLILNLGVEMVFVLNSRLHAQAVPSEQAASVLGDVGTDIFDPVFVDELFTPHPMYSSASVLQVFTALSNSSVMRLSENSMRKLYDLVYMTVKYQVFTLRHPLELLELTLNHLDAAQAILPAGVRQLVSAAEERVLRLASTLNVGDWASMRRSLLNFFTGRHARVSVLLDSKVQDVESGAFYIPRDTFLSPLPACKPPGLVYVAGFPQPGTFAHPDAHLPYPPHVPLGSWSPKRGAARMTNNGFDIYAAAAASFTPATAAGVASTAMNDPLTRQTCEMPIPKRSASDGTSAVTAFPSPATPPSSSLIAEERQSAYDAEVNYLAQLIGSTSRAHSAQEVELELFHDGAGSAGETTAATSVPFVAPKSTSNVTSSGGGAAVAPAVPVTRMTVSLVKDQNKKLLGIMSDFNSPKREDSGVAGGTAPATGGNTMNDLLDIMDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNG1</accession>
    <name>A0A088RNG1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">60S acidic ribosomal protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_150410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an important role in the elongation step of protein synthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">P1 and P2 exist as dimers at the large ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697417.1">
        <property type="nucleotide sequence ID" value="XM_010699115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNG1"/>
    <dbReference type="GeneID" id="22573457"/>
    <dbReference type="KEGG" id="lpan:LPMP_150410"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150009200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_150410"/>
    <dbReference type="eggNOG" id="KOG1762">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2194681at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001859">
        <property type="entry name" value="Ribosomal_P1/P2_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696:SF10">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00456">
        <property type="entry name" value="RIBOSOMALP2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN96764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="107" mass="10239" checksum="51D5F875BDD95CFF" modified="2014-11-26" version="1">MATAQLACTYAALILSESGKTDADSICAVAKAAGVEVSNGMAAAFANALATVNVKEVLGCITFGGAAAGGAAAPAAAAAGGAAPAAVEKKDEPEEEADDDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNL0</accession>
    <name>A0A088RNL0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_200410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698240.1">
        <property type="nucleotide sequence ID" value="XM_010699938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNL0"/>
    <dbReference type="GeneID" id="22574248"/>
    <dbReference type="KEGG" id="lpan:LPMP_200410"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200007900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_200410"/>
    <dbReference type="eggNOG" id="ENOG502RXX1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268530at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="18783" checksum="DB14B9AAC7F45685" modified="2014-11-26" version="1">MVFYSLVLVMKPRPRKYTSQALREIAVNIYNHGGLIRKFSNEGILRPYSRYRDADNTVITYARYVTLQVDLGEEQMSKVEKIIRAHADVNITLRLNNLERPPGVKHNQKNAAAYFPLDTFTRLEEEINWPPQVSGDVYEQLDMNWKEFSRTRWSNYLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNS1</accession>
    <name>A0A088RNS1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein kinase, putative</fullName>
            <ecNumber evidence="10">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_191490</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="10"/>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698143.1">
        <property type="nucleotide sequence ID" value="XM_010699841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNS1"/>
    <dbReference type="GeneID" id="22574203"/>
    <dbReference type="KEGG" id="lpan:LPMP_191490"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190022500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_191490"/>
    <dbReference type="eggNOG" id="KOG0581">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN97490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="278" mass="31633" checksum="8A0AA2A9661EF3D5" modified="2014-11-26" version="1">MSTRRSRLRRVRWLPHQRIVILKEVDLWTEDCVTESVHVVAERLWRIRADARRTDRAQYFAEYLALHVDSPRHYQWLLSSYGPSLRDVLFTPSMTPLTEEHCKAVLRRVLLALDHLHRMSTYVHADVSLGNVLTSSSSWDDVVLGDLESVTPIGTVPSRCLGSYFFMAPERLVDGALPLCPHDDVWAFGVVCYNLLTWDVAHPWCTLGTEADYSENYWALLDLMSKAKDVPPCQLLLQSPLSRCSKEALGFVGACLGWEPACRPSAAELLQHSWMLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNT8</accession>
    <name>A0A088RNT8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_202410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698444.1">
        <property type="nucleotide sequence ID" value="XM_010700142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNT8"/>
    <dbReference type="GeneID" id="22574450"/>
    <dbReference type="KEGG" id="lpan:LPMP_202410"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200029400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_202410"/>
    <dbReference type="eggNOG" id="ENOG502SIR8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267590at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="555" mass="60787" checksum="B0852BFBADAF4659" modified="2014-11-26" version="1">MTSTQRVRDFAGDILAFHETHHDALKGTLERDLHGNLPRHLHSEILQENTAPSRPPTTGTPRSSSYRTPQWAELSECLREVSLAPLSDADAPRVAESRAVPLSRSSSTTTSSLPEYQVVKRLADLSQACDVDPEAVAAALQEAEKVLEAPTDAGRDREYAPRGSATAAERSAAKARLPLGGVQVTSASVAHSEEDLHSRRPRHHHHHRRRQDHHCGGSCTRSPDCVATAARLGATSGCHCFFPWGWPTLPCPVRAGTNISADNHANLHMSSGTAEIIDPAMRWYDVYYAWMLYYQQLYAVQVLQGRQQQCAKHGKRQSCRIHHGRHGDSHTASSGPEVLAGDQEDGTRWVHVERHSRAAAQADRGDVAQGGGSGVAEASPLMNTQPIFHHCPVSPQKPRTQTCTPRALQVSSEKTAKRDDEAARLRAELRHLKEEYTALSSCLVDLGGEGRQFLTCGDRRVRHSATASVAGAILAEPHPARPPAPVALRAKGGKRFGSRDDADPMSHYGSLAPAETWQSLSERQRSKALSPVPHVRTGRGSSPQRFSHQRPQWRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNX8</accession>
    <name>A0A088RNX8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Treble clef zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_202970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698499.1">
        <property type="nucleotide sequence ID" value="XM_010700197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNX8"/>
    <dbReference type="GeneID" id="22574507"/>
    <dbReference type="KEGG" id="lpan:LPMP_202970"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200035700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_202970"/>
    <dbReference type="eggNOG" id="ENOG502S3IR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276277at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025487">
        <property type="entry name" value="DUF4379"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37317">
        <property type="entry name" value="BLR8090 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37317:SF1">
        <property type="entry name" value="ZINC-RIBBON DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14311">
        <property type="entry name" value="DUF4379"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Treble clef zinc finger" evidence="2">
        <location>
            <begin position="69"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="183" mass="20624" checksum="8A2D15C4EC5F22CE" modified="2014-11-26" version="1">MMTCTASMCILRVNRWVSGQLDNSTQSALCVSLRHKASSIRIANRKKVEMFVGKRYHLPTRLRVAAPDIAAEWDHEKNPMHLYPEIVGIGYMHPVYWRCRGCANSYQMSVEKRVVRGFGCPLCEDRELDRSMALNTAAMGTGSVRCGDSDTASSDATPPLLPGEENRSLRPKRTTMLNLRTKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNZ8</accession>
    <name>A0A088RNZ8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_201440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698345.1">
        <property type="nucleotide sequence ID" value="XM_010700043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNZ8"/>
    <dbReference type="GeneID" id="22574353"/>
    <dbReference type="KEGG" id="lpan:LPMP_201440"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200019600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201440"/>
    <dbReference type="eggNOG" id="ENOG502S2KU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1933455at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="573" mass="61599" checksum="468057F6759689CE" modified="2014-11-26" version="1">MAAARQEMADLLREVQKVQKELQPVRSAVAVLQKREADTPNAAATGASLKKVATRLESVRHKYRPYLMRLKELLFDEVPAYLQQTALLAADGESPEHHPDGASRGTRNVPNERLTATFSSSVKSTNDDAAHLLQQVCPPSTPHLVQPENLRFTQQQLRLRTEIVEYLIETNRIDIAEHVLCEYGLPLQWFPRLVLLHRQRIFGTATEGVESLRNTLPPSAAAGVTAATVTSGLSQSFPAPGVSLPVTPSTRPRASGAPPKSPILQHFFASSKSNATGVPAPFLPRSPAPKPTSASSAGASTPMGLHVNRSAASTASSAIHSPPTPQQQQRESGVTSVFPSQAPPSTDTPGAAAAPVTMPDLVVRVVSAAMYLKDEYLDRMVLERTLEQHLGSAASSVSANAASTRGSSTPSPNSATSPDRYKACVLSRIANIPRHHLHTQSGDDAFDNAMMNIIEDLLVYGLQRWAEVDSATVADAEEAAAESKKKAELQLTLTTDTLLTPQEMLLADKVWNEDILFLKRPTRFYCVESGLSTDDGTASALAMPRARTNGEVVSKLVAVNHDALDSTAGIFIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RP40</accession>
    <name>A0A088RP40_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Expression site-associated protein 5 (ESAG5), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_203670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698569.1">
        <property type="nucleotide sequence ID" value="XM_010700267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RP40"/>
    <dbReference type="GeneID" id="22574578"/>
    <dbReference type="KEGG" id="lpan:LPMP_203670"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200043000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_203670"/>
    <dbReference type="eggNOG" id="ENOG502SGFJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="260782at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.20.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032942">
        <property type="entry name" value="BPI/LBP/Plunc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504">
        <property type="entry name" value="BACTERICIDAL PERMEABILITY-INCREASING BPI PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504:SF131">
        <property type="entry name" value="BPI2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="540" mass="59277" checksum="03302643402392A9" modified="2014-11-26" version="1">MSVYGKRSSGKVGARRWWRCLPWLVFLFICGAVISLLQTMSTGPLSRVRMTDANNIVPCPPANISVAVTSTVINRFIAAAVIPKIQEDNNTLVIPEQEVDHVWVGEMVLQHFKLKSLTVNTALPDEQSLVLQSKGFAMEVEKSRFIFHYMGIRCDGTFWVTLNETDAEAVLRLTLLPDGRWSATFPHLEVDWGQLVVYHQLDSKACGIAQKVLEIFIGDFDAFVVSQIKKKLDEEAPSKAAESLNGVFAKIGIRAMTPPVMTADTLRVMLDLNPVDFGCAPAPTASAMPDLISRDIAIRTTLTSVNNLLYNAAQAGRLRVEHDLPAEWNTSLFEDIIPELYQACRECYLYTDVQAAKAPVLDVPQDGEVLVVAKDLILGLYVHPKSMWQVATLSDIVTKKKSGSCAGSAAVSRSFDIKKTSSWRTRRPLPVLAIRLSAACGVRNISAETGRSISYELLPVENVSVQIEASNIGDVNTTELEKAIAKAWNDFAAPLANSESPLRLPPFFQKAILEVGLAAIQGGVDVDLEAEFMQGVFSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPD5</accession>
    <name>A0A088RPD5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytidyltransferase putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_204740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698674.1">
        <property type="nucleotide sequence ID" value="XM_010700372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPD5"/>
    <dbReference type="GeneID" id="22574686"/>
    <dbReference type="KEGG" id="lpan:LPMP_204740"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200054100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_204740"/>
    <dbReference type="eggNOG" id="ENOG502QTA1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5591297at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31285">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31285:SF0">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="1">
        <location>
            <begin position="356"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="557" mass="60510" checksum="D26FDD659733DDEC" modified="2014-11-26" version="1">MSIDLLVEAIHASPIRLSLCICGAGAGVIRRLTRVPECSRTLIEANVLYHRCSTQAALDGLPRHIVSADAARRLAQHAFHKSRDIAFAEAREQLQQLPQLTSTLPRPPQDLLFGVGATSAIKTSRSRHSRDEAHVCIWGGAVNLLEDVSDQSGGSPAMLGEVRHYYMEMPDWLSRAEQDEQVELMVLHAIARIAESCIPADTEVVSKGTHTDGQRSYPRAVFQALLPSAGENTAACGEGVSVSRSSPGLPIVTGSVRLCSMPSESAPESVCLNPSGEVRLALQNVLSAGTSATAPDGSVQDVCALWNIHGELRCSGIPPYPEDARNVAAAVIDHQQESGYDRSAVPAGSRKVIRLLYPGSFNPLHYGHTELVLAATRVLLQQEQQNVEQMALPALIEVTYEIAVKAVDKGVIEVDDLVQRVRQFLHRGERVAVTTATLFVAKARLFPGHGFLIGIDTAVRVLDPKHYSRNEDAAEAEAAMVEALTRDIASRGCYFVVGGRKMSDAMGWQELSLLRIPESVRHLFVGIPATEFRVDVSSTELRAQRNRRGAERRTLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPF5</accession>
    <name>A0A088RPF5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_203480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698550.1">
        <property type="nucleotide sequence ID" value="XM_010700248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPF5"/>
    <dbReference type="GeneID" id="22574559"/>
    <dbReference type="KEGG" id="lpan:LPMP_203480"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200041100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_203480"/>
    <dbReference type="eggNOG" id="ENOG502S6KV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264011at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="388"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="571" mass="62029" checksum="0948C5BD0207D576" modified="2014-11-26" version="1">MNGARRFSAAPVNFDRFIVLARSYSRSLSPDRELDQILRPFQDRRATTTNATKREPPASRVATSQPRHQQRGTGELINNELVATQVLDREPYWGSAQSVATKRSTAAKACSSTRAATSTSRSVSGGAAVTSSVTSTDFSRSTLDDSCVGEETQELERNSYSADDVDPLLHAVLQLGSPLYDPVKRQFVCWRLHTLEKRPRSAYGSIEGVSCDFCGHTDWIEEMAERAMTSPSVCTSVVKVEGKEDLKTPSVGAPLPAQARLFYRCSICQVDICRACLAEVQSDERFHVPCLQCQRCGAFEKRQNAPLHRCAEVRVINVDDEVEVSKGALPLLMPPSRNTDALLMPPMAPPLPSASTVSATMSSKYKSTWVGGRVRVGLSRPHQRAVKGEAAPDAAVAARVEKSAGSVPHRKRKRASPVATSAPKQRPKEEANGSTELSQLGDVRDKTYHQLWQSSSTAMPKPASPKQKEANNADGSASRALLEATGPPSPRYEVHLTPRTPEEVGEVGRIAREQHLVCSPAPSLARACVFYFATRLAAETCVDRATVASLEAVLKCNAKPACSMCPSPLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPS7</accession>
    <name>A0A088RPS7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sfi1 spindle body domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_203450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698547.1">
        <property type="nucleotide sequence ID" value="XM_010700245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPS7"/>
    <dbReference type="GeneID" id="22574556"/>
    <dbReference type="KEGG" id="lpan:LPMP_203450"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_203450"/>
    <dbReference type="eggNOG" id="ENOG502SFQI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265928at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="37654" checksum="AE3812DE043BFEDF" modified="2014-11-26" version="1">MRQRNAPFATQGSSSSSPRENSRLAWCSESFLRQHMRARTSSRDTLLADLQLIRAAANTVVVWRCFLRWGLYAVRRVALRRVQHRAQIVLWRRVGARCFAWWRLVTERRLCREVLYAEAAAREGVLLLDGVCRTAWDKWCQWARAHVRQRGRAVHLGLVSRQRHACLRFRAWTCHLHQCRQLRAVEQIRFAAERSLARFTLIRWRLHTLEGYLTFPLQVRTAQRVAAAAFRVWQRRALIGAGARFICHEALFRVAQSFFDRWKRWLRRRLQSILLQEANEARLLLHIFLQWAWIHQLRALDYEQQVAERDLPRLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQ33</accession>
    <name>A0A088RQ33_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_204770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698677.1">
        <property type="nucleotide sequence ID" value="XM_010700375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQ33"/>
    <dbReference type="GeneID" id="22574689"/>
    <dbReference type="KEGG" id="lpan:LPMP_204770"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200054400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_204770"/>
    <dbReference type="eggNOG" id="ENOG502RQEX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="238179at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="144" mass="16691" checksum="0D537C241B8A7FA8" modified="2014-11-26" version="1">MGYTRERTNRHFFVSRANAFFSRLPIARIQRALAMEAIKKGSMKPWKYTKEQIVGSPVTCNFEYNPRPVRLIGTVMDAHTEETSIKGGLKVYARNEEANMMLWIPAGNPKLKYEVTSAKGSFEHYLDERSKWDEAWLTGRARMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQG4</accession>
    <name>A0A088RQG4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_210090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698797.1">
        <property type="nucleotide sequence ID" value="XM_010700495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQG4"/>
    <dbReference type="GeneID" id="22574831"/>
    <dbReference type="KEGG" id="lpan:LPMP_210090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210005600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_210090"/>
    <dbReference type="eggNOG" id="KOG0279">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6262491at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040066">
        <property type="entry name" value="WDR31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19869">
        <property type="entry name" value="SPERMATID WD-REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19869:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="136"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="178"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="316"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN98090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="424" mass="46969" checksum="BDA0FA1D45635A59" modified="2014-11-26" version="1">MGNTCAKTGEVVDNRNNSQYRDEDLKQYKTKQQIKSKDAQSSLTKEEVLAEHETTSVVKNIEALQHMMKPVVSVVTSELRHEDFRQFTSVFARGKAALAVASCAQVQQPRHILLAGEDRSVALLNYETGHVMRRWVHAHGGDINCITTPTSSGLFATASRDRTVKVWDFTSNGSLAELRGHTMNVTSIDMNPGGNLLVSGSRDNTVRLWDVNRAEELFCGDVKLNLVHFVRFMSSMNCVAQGGEDLVIRLWDVRTQGSHSDLCLSKTIEGMDYYPVCCETIPENPYMLLTGHNGVNSCGSYVAEWDVRTGKRVALYKGHDATVSCVRMVAANIYGKGSFFTSSDDGTIGVWNLEDGKMNREVQLSVEHRFCLPEGHITAFVAEDNGDIIITLDDGCVIALRPAVRGEFVIPSLRLRYVGVLTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQW6</accession>
    <name>A0A088RQW6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_201070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698306.1">
        <property type="nucleotide sequence ID" value="XM_010700004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQW6"/>
    <dbReference type="GeneID" id="22574314"/>
    <dbReference type="KEGG" id="lpan:LPMP_201070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200015200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_201070"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="241" mass="26086" checksum="65EB5B8153DB09EA" modified="2014-11-26" version="1">MALRIAIASVPPFLRSPSTPLFPSSVTKFKVSGITFLLLLGAVKQPMMGLGGGAVAITASTSFVSSVNAEAVSSLASDLIQALTFRGAAQPLRDGQYLYEFFTKTIGYAATIIVDNQAQHRHMPHDALLKPGDPLHDGKVTIIYFSSAALDSKENVNDNVKVCFVPMPVTPLNNLVKSLAFVVVRAEVTYEPLTPDIRLKMDGWERLNHKGTLSPIFPDAFASRCIHHVCFCSGCQGTDHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RR88</accession>
    <name>A0A088RR88_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Qb-SNARE protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_231690</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VTI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699324.1">
        <property type="nucleotide sequence ID" value="XM_010701022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RR88"/>
    <dbReference type="GeneID" id="22575374"/>
    <dbReference type="KEGG" id="lpan:LPMP_231690"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230024900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_231690"/>
    <dbReference type="eggNOG" id="KOG1666">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="430637at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000002">
        <property type="entry name" value="Vesicle transport through interaction with t-SNAREsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.400">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038407">
        <property type="entry name" value="v-SNARE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007705">
        <property type="entry name" value="Vesicle_trsprt_v-SNARE_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF26">
        <property type="entry name" value="VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05008">
        <property type="entry name" value="V-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Vesicle transport v-SNARE N-terminal" evidence="10">
        <location>
            <begin position="53"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN98617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="283" mass="31258" checksum="CE842BEEE09D1E67" modified="2014-11-26" version="1">MTTLFQTYEEEYRDGLRAIRDESESLRQSCDRRAAGYKAPPATGPGSRLQRGAHLTTVLAQLRELVNSMEYEANDLPAAHRQTAKERIVEYRTNLRTVEEGLVRLKADASAADRLDLLGSTEARKAGADGANKADASNDLDDATRAHRITMLNNTAQFRDASDKLQKAERLLNDTETVGNEALTSLRYQTETMHHIQETTIAVDEEVSDARKIISGMQKAMIKHKLVLTAIIIVLLFLIFVAIYVSSAKHRRNSSSSTSTEATGDPITSVAPSLSWVTRKGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRA0</accession>
    <name>A0A088RRA0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_230520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699210.1">
        <property type="nucleotide sequence ID" value="XM_010700908.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22575256"/>
    <dbReference type="KEGG" id="lpan:LPMP_230520"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230010600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_230520"/>
    <dbReference type="eggNOG" id="ENOG502S5VJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273634at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="966"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1365"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="572"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="662"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="801"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="998"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="373"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="982"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1385"/>
            <end position="1399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1405" mass="155911" checksum="C46EBF9701DD8638" modified="2014-11-26" version="1">MNVTWQSSIDRTLRSTEATLEQLQHRRLSYDRAKRKVDDYLGTSPNVHSGQPALDMFDQDFSLPPPLPQHLRYRAACVAGPSPPASTLLDYSTPARRSRLLSSAADGADQRPTDLSSSPLQLVNAQVRGALLELELEKAKRADSVRELAYRTTAEFAEMRSLITQLQTENGALKKSVRALEGRLGCGGNSDGLHKSAANGTATTDDGAFSVTSLGALAPPTRAGTLPSVAINSRFGLGHDATMPASAAASLVARVEALESGFARQQQHIEDRQTRVTSALHELVKAEVGSEISQVRALAREAARDSAEDLLKLRLSALQSSTQADLQRALHAASASETVAQHVQQQCHESEQRLSSHMLKVQAQLSEWQRTHGGNASGSSTTVATSGTSQEEKERVAAVERRLDEQLCSMQSQLQQYRSGVETQIDRLAQQHNALSGVVEGKADAAELLAVREHLGEQQRGDSSGWMSRDQVTALLRAQLQPLYDEMHKAQAMAQESLDNTDAWRREAARRFATVEAGMKAQSAETQQDQQWQSCARDVQQVRTEMNSVQPRVAEAVRQAKTELVNVWDAKLQLLEERTQQIHRERQQQTDAQLRQLQQTLVEQQEALQRARMTGESVEERLRRTEAALAAVEMTLPRTAEDVRVKYEALQAVMQQTCVLPVTRVKQDIDAAQRKLQAVEEDRAMLNNSWKQQLAEAQHYHEERVQHTREVFEQRFAHHKELYEELRTQQTLQRRATEEQHQQLMDRVRHLQQQQHRFSSVVAPMTVREQSAEVASTHALATAASISIAGTTASGEYQRSLQLLDSRLQDLDSRLDTVEEASASVPLTIADATSSVAKRLEGLQDRVQAQVEDWQRRHNELERDTERQLSALSRRCSETLAFIDAQSARTTCAMDEALSPLKLVTCLLTDKSCLQHLALRLRDYLALTLEETPALADVRVHLATLAKTLEAVQASMQQAQHEIAGLSERSRADQAPGAVPPSSSEMESATAAEAATARQEMLDLIHNLQVTLEEQRERQDHLEESLRHLTVQQLATVTKELAEVKQVAESVSLEIAKHSDHCNALQSAQRQQLPTLQKYVQDIVQVVESNQSSQLDPIQLRLRAVEDRQKHLQTRLEEANATQEADVVQRVQELHKRMDQQSEKVHKALEGQLASLRDEVIATRTDADSLAKRVAATEQAREHVMGMLATLQAAAPPAKAAEALMTPDAVAEEPLDIREIDERLTQLEKQAHDSVSVTAEMLGAFRDQLQNVVGRFAAAAAQLTGHTERSGARAAVAATEGASSLQPPIHSLEDVFLFLLERLLQLQQALQQLQSSTVDTLEILERHEESVASLPMLQHTVDLMADTLMPLAERLGVERGAVCTISPQQQQHHHHHNHTSLFPPSRSSSDSENSEWVSEGLPGHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRE2</accession>
    <name>A0A088RRE2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">p-glycoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_230230</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98475.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699182.1">
        <property type="nucleotide sequence ID" value="XM_010700880.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22575227"/>
    <dbReference type="KEGG" id="lpan:LPMP_230230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230007500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230007600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_230230"/>
    <dbReference type="eggNOG" id="KOG0054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000082">
        <property type="entry name" value="ABC transporter, multidrug resistance associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002055">
        <property type="entry name" value="ATP-binding cassette protein subfamily C, member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000010">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF415">
        <property type="entry name" value="FI20190P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN98475.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1573" mass="173003" checksum="3A800EE3F63B51D7" modified="2026-01-28" version="2">MLHEAVNEELPMEMAPAQLSTPSPPWRHNHQSDPLHDYRTAHLKLQERLAEMWGPEAPYTPVPEETSSWFQRYYYGWVYETVLLASKEQLVREVLPPPTQDARAHECGLRLSRAVQAAMYDRNAWNCMVGAEVASTLDPASRGILRWVGLPQQGGYTRMMAGVEWSVPPTARTAERSNDSGASPFFNGIVHGEHLFTPGHSDMSTLEDSTMVTLNLTNCGGVVRISTPKCVPLRCLLALKLPYYLWMQVPFLLVSSICTIMIPTVLKLFVTFLDDDPSTQTWGRGLGLVVSMFIVQATQSVSHQRSIYIAFRCALQYRAAVNSLIFEKCMIISSKSLSQPEMNPGRIINMMSTDVERIYFFMLFCMSLWSSPMMLLLVIAQLSRLVGWCAIIAVFSFLATIPLNTFFMGIQMRARQEITKAADARVKATNEFFSGIRIAKFMAWEPCFVANIEAKRAVELMFLKKLQNARVATAFVNNAAPICMIALVFTVYYLLGHEMKPAVVFPAIALLGILRQLFKEIPWVFSMVIQFIISIGRIGKFLECDNAVCSTVQDMEEYIREQRGHSTACQLAAVLENADVTAFVPVKLPLAPKVKMSLFSRALRMLCCEQCRPTKKRPSPSAVVEDMSYSSPSSTLRHIIVGGTSAMGGAKSASTRSTKTPLMGTNDFFELEPKVLLRDVSVSIPRGKLTVVLGATGSGKSTLLQALLSQFEISKGRVWAERSIAYVPQQAWIMNATVRGNILFFDEEDTARLADAVRVSQLEADVALLGGGLETEIGEKGVNLSGGQKARVSLARAVYANRDVYLLDDPLSALDAHVGERVMEECFLGALAGKTRVLATHQVHVVARADCVVALAGGRVEFSGSSEDFMQTSIYADMTTGEMDNKEGKNAIKPESVLEMEEEEEGGTMLAKRVSKPKEKAKVGGAVSGDTTASAFIIAEEKASGGVPWSTYMAYFRCCGGVHVGAIVIAVFAVTELITVSSNVWLSRWATKEAGSSDSRYLTVYLLIVLASAAGYPFRFSLSYSAMRSGCSSMHRAILRSVTGGTMEFFDRTPLGRLLNRFSRDIDTLDNGLQISTISLLDCLCSISASILVTAYSQPLVLIALVPCGYLYYRIMGFYNSANREIRRQASLLKTPVFTLLTELTNGLATITAYGKTRIVMAEALKRLDVVHSCGNLENTTNRWLAVRIEFLSNVVVTSIAFASVVTTCAHLTRVEVGLISLSLTMAMQTTGELNWLVRMVAAMEADMNSVERMLYYIHEVPQEDMPELDVEVDTLKKRTGMAADVTGTVVIEPASPTSTAPHPVQAGSLVFEDVRMRYREGLPLVLRGVSFQIAPREKVGVVGRTGSGKSTLLLTFMRMVEVCGGAIRVNGRDIGAYGLRELRRQFSMIPQDPVLFDGSVRLNVDPFLEASPAEVWAALELVGLRERVASESEGIDSRVLEGGSNYSVGQRQLMCMARALLKRGSGFILMDEATASIDPALDRQIQATVMSAFSAYTVITIAHRLHTVAQYDKIIVMDHGVVAEMGSPRELVMNSQSLFHNMVVAGGPSVLRHFLSLVSRRGNEVMLCSECG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRL9</accession>
    <name>A0A088RRL9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_230950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699252.1">
        <property type="nucleotide sequence ID" value="XM_010700950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRL9"/>
    <dbReference type="GeneID" id="22575300"/>
    <dbReference type="KEGG" id="lpan:LPMP_230950"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230016100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_230950"/>
    <dbReference type="eggNOG" id="ENOG502S1QF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="263382at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="25074" checksum="98783A10D468F520" modified="2014-11-26" version="1">MARGTRGADHQPDPSSSRQRPSVASVCKSKHGPRSNLKIKKKAPWGAQQLRDSWSEDAMSKRDRDSMDERIHREYRYHPDEFRRHYIRYTAMLTIPCIMFGMSITYYYETGRPFWHADPQHLLNLLRAMDTSPRSKLYAYRLADTHDLPAHVLKHKSENMEKREYEERVFRLTHSAFERPSRDALRLMELEERLKTNERASEVAVPEELEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRT2</accession>
    <name>A0A088RRT2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin/TPR repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_240130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699355.1">
        <property type="nucleotide sequence ID" value="XM_010701053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRT2"/>
    <dbReference type="GeneID" id="22575422"/>
    <dbReference type="KEGG" id="lpan:LPMP_240130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240006100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_240130"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0548">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="17481at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051616">
        <property type="entry name" value="Cul2-RING_E3_ligase_SR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46224">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46224:SF64">
        <property type="entry name" value="IQ MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="43"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="76"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="109"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="176"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="210"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="277"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="394" mass="43154" checksum="7952DFB3789ED4F3" modified="2014-11-26" version="1">MDDGTRISEDVEKFLRAARSRDAADCSRMLKEKPELANSVEAGGYSALHFAAFNGDAQMICLLLEYKANTNVENMDGNTPLIMAVKGRQLECIRILVNAGADVNKESDSGSTAAHYAASMGYLDCLHLLVELGAKTMYTDSEAGTLLHWACHSGDLNCIGAVIYEFNVPINAVDKHGGTALFTALFMKKVDAVEFLVEHGATVNIAIAEDGSTPLHIAVEHANSECVRLLCSYGADVSAKNVEGKTPLDLAKVANNTNAVKELEKTQVLPEKRAEAAARFKNQGNKVFQQGENVKAAKFYTLAIHLDPTNHVYYSNRAACYFNQQLYTGAYWDALRCIKLDPSWPKGYLRKAATELALKRYSDASTTASQGLKLDPTNKDLQQVKDEAFRQLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRV0</accession>
    <name>A0A088RRV0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_231770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699332.1">
        <property type="nucleotide sequence ID" value="XM_010701030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRV0"/>
    <dbReference type="GeneID" id="22575382"/>
    <dbReference type="KEGG" id="lpan:LPMP_231770"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230025800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_231770"/>
    <dbReference type="eggNOG" id="ENOG502SJK5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272149at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052595">
        <property type="entry name" value="LRRC69/RLP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48057">
        <property type="entry name" value="LEUCINE-RICH REPEAT SERINE/THREONINE-PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN98625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="33538" checksum="49D8E7481D6DE59F" modified="2014-11-26" version="1">MGGATSKDRYDRAVSTGILTLNKQEVKSWRRLTKALKKLSTLRTITISHNPLRDPVPSAFTALSLWSTLVSLDLSHNCLTCACALGSEAPLSKTHVEEALARITMAPASHTVYGFPPLPLESLNLSGNDLHMLPPLLAVRFPRLRRFVCTDNKTALNIPLSLARCIGASKSLEVVALQRDRLKTFIVADDTVNNPFPALREILLDQNHLGGTVNLGFAADKEAPMLPSLRRISLDDQTGAEPLRHIHATIFAHCPGLTSFTFHGNCNEAELHDSLVQSDVYRSWEVRMKDVVDKKLHAGGRAELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSB9</accession>
    <name>A0A088RSB9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_251640</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699734.1">
        <property type="nucleotide sequence ID" value="XM_010701432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSB9"/>
    <dbReference type="GeneID" id="22575812"/>
    <dbReference type="KEGG" id="lpan:LPMP_251640"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000048300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_251640"/>
    <dbReference type="eggNOG" id="KOG1164">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14016">
        <property type="entry name" value="STKc_CK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="22"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="457"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="488"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN99027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="516" mass="58122" checksum="1AA25E4DDB10865E" modified="2014-11-26" version="1">MAVSSEPYQPTGKEVPFGRGRFLLSHRLGNGSFGDIFEGYDKQSQRIVAVKLERKKARYPQLSYESKVYRVLHQPPLGQNEVSLKQLLMESLNYSGAGSFHGATAQGSSNINPSASAKAIQVQHCKSLEDRIVVGIPQIYYFDSEGDYNIMVMEMCGPSLEDVFNYCHRRFSLKTVLMIADQLLHRIQYFHEKGFVHRDIKPENFVLGCRSKAHILYIIDYGLSKLYWEVKKNSHIPFVEGRPLTGTARYCSINVHRGFEQSRRDDLESIGFLFVYFLRGNLPWQGIQTKDQQIKTIKIGETKIATPLEVLCKGLPKEFLKYCQYCRALTFTQKPDYDNLRRLFRELGERLGLTLPMPGAPSGNLSAAHRTAVSLPNPLAASALLATDATSATESRLLSVVSGSTLNSRHSQQCHAPSTVAAPLLLTSEDFDPMRGPYDWCFDWFCKRQMEVSKGTEEQSRRQWGHAQPSAVASGNSELRLEDVSDVEGSTQTKSTNFGSHRPPLRNLLQSGRLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RT14</accession>
    <name>A0A088RT14_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small nuclear ribonucleoprotein Sm D1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">snRNP core protein D1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_220960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Essential for pre-mRNA splicing. Implicated in the formation of stable, biologically active snRNP structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the snRNP core protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009391">
        <property type="protein sequence ID" value="AIN98389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699096.1">
        <property type="nucleotide sequence ID" value="XM_010700794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RT14"/>
    <dbReference type="GeneID" id="22575142"/>
    <dbReference type="KEGG" id="lpan:LPMP_220960"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_220013000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_220960"/>
    <dbReference type="eggNOG" id="KOG3428">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9626941at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01724">
        <property type="entry name" value="Sm_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000068">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034102">
        <property type="entry name" value="Sm_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="6">
        <location>
            <begin position="12"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN98389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="103" mass="11306" checksum="5FCA71C5F320E3C7" modified="2014-11-26" version="1">MASVSPSETGSTLITFLQHLRGTLVEIELKNASIVSGEIAYVDANMNTYMSHVKITSKGKNPVEVEEYMVRGSTIRYIILPESLNTYDVLKQASAKKNGAVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RU10</accession>
    <name>A0A088RU10_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_272380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700324.1">
        <property type="nucleotide sequence ID" value="XM_010702022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RU10"/>
    <dbReference type="GeneID" id="22576416"/>
    <dbReference type="KEGG" id="lpan:LPMP_272380"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270032200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_272380"/>
    <dbReference type="eggNOG" id="ENOG502SP87">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270488at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="113" mass="12656" checksum="6043C8F15B51F5BE" modified="2014-11-26" version="1">MLYIAALTLITFASTFMVADTVANIWQLLSRGRVALISYSVWMAALTLTVLGTDWLTMLGLLHALIFVGCWWLVCDGDGAAHASSTRDDYVRFPVTVYVPVFMVLYFLQGWLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RU82</accession>
    <name>A0A088RU82_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_241870</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699526.1">
        <property type="nucleotide sequence ID" value="XM_010701224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RU82"/>
    <dbReference type="GeneID" id="22575596"/>
    <dbReference type="KEGG" id="lpan:LPMP_241870"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240026100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_241870"/>
    <dbReference type="eggNOG" id="KOG0301">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10265988at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001534">
        <property type="entry name" value="WD domain, G-beta repeat/PFU (PLAA family ubiquitin binding), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.870">
        <property type="entry name" value="PFU (PLAA family ubiquitin binding), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015155">
        <property type="entry name" value="PFU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038122">
        <property type="entry name" value="PFU_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF0">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09070">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08324">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51394">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="59"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="162"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="204"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="245"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="290"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="PFU" evidence="9">
        <location>
            <begin position="396"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="PUL" evidence="10">
        <location>
            <begin position="518"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="504"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="507"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN98819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="822" mass="88033" checksum="6721A2B1BA9CCAFE" modified="2014-11-26" version="1">MCDEAFILQADGREHISDVRFVSSLPHDPLAVLTASRDNTAKLSTIPTSGDTVVGGLTFIGHTAFVNYVLFHPGMELLDHEACIVTGSNDKHVALWNAESSAVEAVLDGHNSGTCCGAIIYFTPGSVDTEVEDALAGDIISGDWSGTVLIFDHKSGRPKQLYNKHSTAIRGVAQLTNTSAVVTGSGDKMVHAWDALTGKTIQIFSGHQDVVQCICAVDSTRFASAGNDCTVQLWSIGTEGPLQVMHGHDSLIYSISWSPALSELYTASEDHTVRVWRSSGAASKLSTVQVIQHPCVVWSVAPTSDGRLLSGGSDHTVRVWTRNYEHMASIEKLEALETAVSSQTMDVKIAKSSCSAAASGGLNLESMPFTHEIVQRRGTLEGERLFARNEKGEVELYVWNVSRWEKIGVVVAGTDAQRYTGTSEQQREKHFYKGQSYDYLFDVNVEGRMLKLPYNMGDSVVETAKRFIQDHAGVVAQDSQEEIQNFLMAHVSPEDLLRIPGLESTRRASSSGTTATAPLSPPASPAEAERLLPAWEAPQLFDTFNAAAAQTKVNALLPGHTQFHYTVEAVSPNPSDPSVTCSDLLSLYAALPAGSRFPATDALRYLLTVTVDRPDIVGETLAKLATIWGSQAQPPQLPTSAAEWMVALRLAASVFGRLCDARVQAPTMTGDAQEMLVWLAASLPSMTKLITSDTPASMRTNCRAATAALLRNVTVALRSPGSSLATAGPVSLAERLAVAVVQQSAVLFVVERNDSPVVRDSLRSLRSLLLPTSPSPPAWRAAVVAQMLSSLTSSLKGIATGACVEGQPTAVWLLAQVGCPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUP0</accession>
    <name>A0A088RUP0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_280790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700420.1">
        <property type="nucleotide sequence ID" value="XM_010702118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUP0"/>
    <dbReference type="GeneID" id="22576524"/>
    <dbReference type="KEGG" id="lpan:LPMP_280790"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280013400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_280790"/>
    <dbReference type="OrthoDB" id="271972at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="481" mass="53847" checksum="09DD472F4D969E7E" modified="2014-11-26" version="1">MTFSLESADLHIEKPVIPAYHKQADFAAFLVNEYFTKPSKQIEKARYDDTNGLLPLMSFDCLLPSGDIERIVGHICEETHLIDERHVQHRKPFHILEKPLLIPAILAALLHRILFEEVGVTISSRTFDLWASTALGFPARTSRLWLDASAQVEEALESSSVKQLLSKRSACDTGIHAIKKQASPKGVLFSLWRNACSMLCASLVRPLFSTERCQEHFSQAINRSIGFRRELASKMSSALHGKGAACFSLYAAGEPELCSCVVFHSFFRQLEALFHGVIDSKLKMNISAHISCAVFVGCLNTFSYYRYSASKAESMYKLLDIVAEVTDGKSVAYRFDLKSIEVPQMSRYVQRATVLSSDEVFSGILYRRARKETSASSACTLPRFTEMNYNAISITDIYPFCMETGTGAESDEMGECSDHTDLEVHPEPEDEGNFVEMTTIFLDAAGDDRCLQYILSAEEVAVKKQLQERLYGGSQGRKKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUS1</accession>
    <name>A0A088RUS1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amastin-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_281200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700460.1">
        <property type="nucleotide sequence ID" value="XM_010702158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUS1"/>
    <dbReference type="GeneID" id="22576565"/>
    <dbReference type="KEGG" id="lpan:LPMP_281200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280017900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_281200"/>
    <dbReference type="eggNOG" id="ENOG502SKSJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271020at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009944">
        <property type="entry name" value="Amastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297:SF4">
        <property type="entry name" value="AMASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297">
        <property type="entry name" value="AMASTIN-LIKE SURFACE PROTEIN-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07344">
        <property type="entry name" value="Amastin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="431"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="522" mass="58439" checksum="218B3302BBACA72F" modified="2014-11-26" version="1">MVSGAKQSPLPGDQDQACNHQSDQYQQKDHRAEHQRGEVPPDDEGEEAAHQHLKTGGTPSFYSKAHSDSLTERYQQRVEQASSVWLSGILSGRSYAPRPKKVYETELSDSTNMKLLKERTYTIPRGYKYFQENLPPVLSPVPKNGYRAALFSHIIFFSIAFVFTLVAACPIPWYRGKNVEESGVNYNERTFNLWKAEGGNYSAVSVRTMKDCPVEKQFYQTIAVCTIVGCVLSLVSLLITGARLVGRSSYGWILLFSFLAFLWTLCGNAMSIRLYYAARCDAPQFSHTARLDVGFALSLLAWIFQLCGFLALFLVTKMNVGPVLNHLRVMDTFYMALLCVSLLFLCTANASTVWKRRFNTLDVKVVRVAYWHTELIMPNGTSLYYAHHHYGCDAFSQCMKASISFLILSSVALFFAIMLAIPAFVSRGCRTISVVFSVITLVFLMVSWVTAVVVRYRSSCSGAIDGTWYQQYPGVPSGIYNGLTSFPGYGVQEGLILPIVAWVIVLGATVLNMRIPWPEVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RUY2</accession>
    <name>A0A088RUY2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FCP1 homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_252110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Probable phosphatase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CTDSPL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699781.1">
        <property type="nucleotide sequence ID" value="XM_010701479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RUY2"/>
    <dbReference type="GeneID" id="22575859"/>
    <dbReference type="KEGG" id="lpan:LPMP_252110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250023200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_252110"/>
    <dbReference type="eggNOG" id="KOG1605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000015">
        <property type="entry name" value="CTD small phosphatase-like protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="6">
        <location>
            <begin position="176"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="87"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN99074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="366" mass="40160" checksum="306220EBE9725823" modified="2014-11-26" version="1">MDGERETNATPTPFFQGISDKLESQQQQRQPLSSSRLTVTSSNGVHVMSANHYRRGGAGGGATPPSSTTTTPTSTVMPVSTLITQVSQHVPPSSQQQRNIGHGGGYGDSSGMDGSGNAHAGPRVAGGSTSGTTGSRQRVHATELVERARYIRNQPKNTSPIDASVHPSLLPDPLPAVRNKKCLILDVDETLVHSSYQSTGRYDVHLPITLDHDTHVNVYVAFRPHLHRFLEAVAPLFEVVIFTASLSTYCDPLMDSIDKQRILGGLRLFREHCSVVGTTYVKDLSLLGRNLEQVAIIDNSPIAYLFQQRNAIPITSWFDDSHDEELLRLIPVLEALAEADTVYDVLDNYNALLQLQQHHENNREKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RV60</accession>
    <name>A0A088RV60_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_281670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700507.1">
        <property type="nucleotide sequence ID" value="XM_010702205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RV60"/>
    <dbReference type="GeneID" id="22576612"/>
    <dbReference type="KEGG" id="lpan:LPMP_281670"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280023000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_281670"/>
    <dbReference type="eggNOG" id="ENOG502SH0X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267065at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="475"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="511"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="559" mass="59655" checksum="C0BE576848275F64" modified="2014-11-26" version="1">MDVPLRLRLAYANCLNNVYCDGRNVRCDAKPLSCDLSYTSRGAEHDGRHWLSSLVASVESNQSEEALLHTDLAVSASLLSPLVATEFMEARAPQSSYIADQKLQGCLEKRESVDQLAAPSPRPSDNIGAAPFSPRTESPVDEMPPESPHTPFATFSKTAPLPPASPFGPDTQEATRVESAVQANVAAQVEADAAARAHTVRVNEELAGTHEALLANVTTALERRLRECVLKTVALDDAQQQLICAFQLRSSMSPASPSPHPLPVIPSTAEAFHASSAPPTRDQLTKQAAPARTDVSSCATAKQDAASGEVADGPAAKPAAVDAAAPLPWLSANRTDTSLSDDVKKEVALHLYALSRQVQQLRSHLEAHESTHYRHVNALRAAQRQRRGCAPLPLRVEIIKGYEDDPVPYRKGPWREADFAAARRGGQDLSAGGMKGDAASDESYISDDFTEVTSATSSVVRTGTGRESDGEGSDDGSSSTVSSTEELFRQRQAAALRVRNQQTVARSVTVNAASSSRNRMSDSSADYSSSLASTAMTTDTRSASRLTTTTSTDDDSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVP9</accession>
    <name>A0A088RVP9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_290400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIN99990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700933.1">
        <property type="nucleotide sequence ID" value="XM_010702631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVP9"/>
    <dbReference type="GeneID" id="22576804"/>
    <dbReference type="KEGG" id="lpan:LPMP_290400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290009200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_290400"/>
    <dbReference type="eggNOG" id="ENOG502SIIT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267944at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="574" mass="60492" checksum="AA4AF562EA841409" modified="2014-11-26" version="1">MLSLLINQCGAKASDLPQLVRLTELIRAEKEGAAGGFTVAPTPLATQTPLPPPLSTEPGEVTRVAGQAAKSTTLSVLTSAKDHTALGFLLHNCASPAEQSQCTMLQQLYGLLLAETHEGGASESADGGFSPLRVKPSTAVPVHPATTVAAGAERASHRHHHPVSSDAIATHEQRSDATTTAPLSALLDSGPLLPPSIPVPILPDPGNWEGAVAFYPAATAAPTHPSTPPVPMHLVSAVAVTGIAAVAADRNAMRDGADGLRANSPLLPSSSAELPPNDDDEQAERNRESGVVLFPAPASCTDETSAAHATHVEPVAGEGGRAELGAATLPLPRYPPHPSFYAGRMPCPVNEALAARNSATLRLLAGCGATRWASSLSPTSRPTSGPAKRFTSGLYGRASTPRGGAFSSPIPSQQQRYTPHPPQTLPIRGGVEVIRAHRTLSERSLLPVRPAEPWQAWQAVDTVRVSSAQGRVSLLAQDVAPRLRFSTSTPHHHRYQRRVTGAEPPRPPRAFPYNPATISSGVLPCVRPFRRRSSLSQYVRDNSDAPTVEPFADLIVVGTRIHLPSLHPTRPRYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWX4</accession>
    <name>A0A088RWX4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kinesin, putative</fullName>
            <ecNumber evidence="7">5.6.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_303020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.3" evidence="7"/>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701324.1">
        <property type="nucleotide sequence ID" value="XM_010703022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWX4"/>
    <dbReference type="GeneID" id="22577355"/>
    <dbReference type="KEGG" id="lpan:LPMP_303020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300034900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_303020"/>
    <dbReference type="eggNOG" id="KOG0240">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00106">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000140">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2 3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="6">
        <location>
            <begin position="83"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="44"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="766"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="708"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="807"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1075"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="160"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO00524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1191" mass="133347" checksum="D27ED6E91E7A7A9B" modified="2014-11-26" version="1">MNSAEDLSVDTASAIEDEDACLRSGDALDEDNCGLVTAASPPSIASDAARAKATKPVKGPFKGRPSGNGSAVEGSDDGQALSRCLVYCRLRPTIKKDYKEGGHPLVTLEDKRVVVKDERHYDLDGSFGPLAEQADVFESVAVPCIDHAFKGFCSALMCYGQTGTGKSYTMCNTDPQHLGIIPRAAKYIFKTIQANEVSDPTRTYTVTGQFVQIYRDNLGDLMVHEGRDRVEIHHEEEKGVSLAGCTSHTLASSKDFMRFYNEGNARRVVGSTAMNAESSRGHTAMIIYITSEDTVDISKGKLRGKVTFIDLAGYERFSKTGITNADPVRKDEAKTINASLLALGHVVSSLSAGTKHIPWRNAKLTRILQDSIGGRSRTSIILTVGPSSEHLYETTNTLQFGLRAMAVKVEAKVSVTVDYVKLSKKLMGLLNERDERISSLEVQIASRDAERQELLERYQRDRGDLERRFTAELQHLTASGASEQQIRNLKEVYQAEIENLQDQQQEEIGYQDEIQSKEITQFIKEQKRQEAKSLMEMKLARERLVEEFQRKLDSARGGTNEDLVRALQQLAEKDAILASRANDTARLHATIDVLTAQVRSFGGTVQADIDFPETFLDVSQVEEMQARLQSEVERNYNKVVDLSTQLDRASMLAHDRMEEVSKLQQEAERLHEKLLHVGVEISESNEELQALREKRAELVDPEELESLRLLMQADIDELRSQRDELQAEVRRLNEARVRDSMARRRSLLDGPDALKRILAEDEEEGAADVCDSAAHGQGRGDPVNAADGEHKMGPKAKAMQKAYKKMIQKLNCQLADSSRERASLVQRVQQLERTLSLHGIAVQGTSGCRTEDKEAGSAHAGNARGCPARLDASALLRESSSADCQTEESLVAAGNTDTALVLLFKEQEIEVRDDLIAQLETQLSKAVSAYDKDQRYIEELKALLRDAGETPHEASSSGTQPVEGLPLEEYSALLRQLRTHNRKLLVALLVMQSHQMAGATDSPTTEQTVFEEQLKERDTELEMKDEMLLEKNAMLQYMATLSARLINQMEALGLEPCCHLPERYQDLVKAEKGQLDIQATKQRELEVQLQREQDEKQKMKRLLEAINAEREQSAAVLRQAELRNKELRERESNATTALQELAERTIQKEMIREEALWRTTQELMELQARCANQQHRRSSNLFERLLRSIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RX27</accession>
    <name>A0A088RX27_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_303420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701364.1">
        <property type="nucleotide sequence ID" value="XM_010703062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RX27"/>
    <dbReference type="GeneID" id="22577395"/>
    <dbReference type="KEGG" id="lpan:LPMP_303420"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300039100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_303420"/>
    <dbReference type="eggNOG" id="ENOG502SE9B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266757at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO00564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="143" mass="15420" checksum="18B9ED4C9E38D142" modified="2014-11-26" version="1">MGTYLSLLVHKRPRECVSSDSSIADDCSASDAAPFSPSSLSCLLLSLRYRCASPDRIGSEVCRYIAEDGAMRRTYGCHAHIYETDTADESHGVALAWRVDEFAAPLSALSLLSLCRVANSCRKKTLVTTPNGEAVVLAYTAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RX84</accession>
    <name>A0A088RX84_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Seipin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_310170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701409.1">
        <property type="nucleotide sequence ID" value="XM_010703107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RX84"/>
    <dbReference type="GeneID" id="22577443"/>
    <dbReference type="KEGG" id="lpan:LPMP_310170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310006700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_310170"/>
    <dbReference type="eggNOG" id="ENOG502S0CN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271666at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="409"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="510" mass="57115" checksum="393AB4AE5D2B9C57" modified="2014-11-26" version="1">MERAHHSPRKASPPVPMSGFVGATVECLHAVLHEVVLLLQALQASIALQAKQSYETSSVRLYTFLDTSRCCLRLIVIVSLMLIAALAVLLVDLSGCLVSSVATAAGIRHLVLANVPGTAVIPLHFNALPFHNDDWQRHLPEDKALKDFLLPDRKTRALVESMAQRADSLSAMQQHMGQFADAKFSFLSHFVNTHLASSTMHIPRTTTSAEVFSPRGGVNLEGLFQFGPVMFNAKGEYTAKMQVVLTKEEVGRDVPLILESSMLFSEDATAVQSVAQFDVLFTTSTSVTIRTGPSYRPWIELLLRKLLRFWFYLPVWSYEYLRSALHQRDSAPFPPIDPSREVAVVLEVYNRFTPPLTLQPRLRAMNFTLYQLPDASAPSRVKVSRLVFFSTVQLTGVARWLTDYPVATFLLLVAVFFAVFALTSVGGLLGLLVYVYWRWFRRRGLAPFAADGLTEEVVALPHDRPAAAVKRVVTPHLRRHRSSSDLYDSLDTSQLRRSQSFNYTPEKKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXA8</accession>
    <name>A0A088RXA8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_311940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701583.1">
        <property type="nucleotide sequence ID" value="XM_010703281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXA8"/>
    <dbReference type="GeneID" id="22577620"/>
    <dbReference type="KEGG" id="lpan:LPMP_311940"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310026300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_311940"/>
    <dbReference type="eggNOG" id="ENOG502SHNE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266529at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="668"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="801"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="346"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="430"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="690"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="722"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1046" mass="110286" checksum="F057548040A8117D" modified="2014-11-26" version="1">MSNDDFQTLTGNSSLLSYSQYDIPLFHSIEVPPGKAQVHPDPLSPPASPQALVDRTKPRTSLRTNRQRYSSSWQRGSIELMRSDCTPETSKLSGPPLREPGADTHGDLFGSKGPFMYVDDYCASSSSVSGSGKLPFLSGTNSPGQSGGLGRSSIDTTTSGNLKNLARRLSRSGAIQDSVDASKRTPLPGAPASLLPTADTPSATATGSDRRCSQDNSSGTGSTTAPPAAQQREPTSAAHPAQFASSGATSRVIKVSPTTLTLPQPSAEFTLLLDYPIIKDRGSAARSSGHQLSPQALASQSSLNPSRGARGMAGNADSRTLTPLGVEDIPDKQARHRSTLGGVLSSVEHSSFSPSPGWRSSSSVLSSSSPVPCARTASDLRIRSEHHNLNRSGSGAGGMSPVRQQRAASEPSPTALERGNHVSLCRTVQPPVQSVSSTPTSACVPGVGTTESSGYGNRDEEEADSSSLACQPGYDLSCVPGAVEDTAEAKIDPLHYNTDALDGDKDGYSSLVNLQDEEEEPSVIRSTEKPPSEVSSRSTTNQHPKNETAPALTPPHAPPMPKKRFFTLEPVRTNTSAMAKGGNSKLRFDGSGVANRSDEELSSESSMFCAMRPLHLADPNASLSQSLPLTARVPGLLLHDTRSEHALGAVVTNGAQCLSMPLQSTNAVALNGKAPPTGTTESRRARLPSTVLSNTTQDGAQALTTLSGNTNSSEPNSREASEAAASSSISPPPILSTISWAQPMCATTLSDELQNPLRPLHCRVCIHTDTNGIDDAPTTQVPWPLQNPPSSIIVKRRLFDPKLPRPRGPRTRGLLNGKRQADWTPPETHYATTLADMAAFEEDEDGIQQCHLTGTLWDDEVIGMDAPVSRLPEMRGGQLSSCSTPVLRRGILGVMLRTRSPVSPPRVPLVPSLVPMTLSTSPETPAVLEENVTVQGSPQLVSCAPPTAAASGDAPTSVMWGSFSTSVNAGRRTGGIVVDEVEKVHRLREESAITPVLEALRIEPSSLLSHSAAVRLASQVAPSHRCLGASIHPRHSVDSKKGVMEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXE3</accession>
    <name>A0A088RXE3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_312400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701628.1">
        <property type="nucleotide sequence ID" value="XM_010703326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXE3"/>
    <dbReference type="GeneID" id="22577666"/>
    <dbReference type="KEGG" id="lpan:LPMP_312400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310031400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_312400"/>
    <dbReference type="eggNOG" id="ENOG502SHQC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272990at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="699"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="848"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="935"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1068"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="727"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="848"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="939"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="965"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="977"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1001"/>
            <end position="1013"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1107" mass="118598" checksum="5DB34C058CB4F27B" modified="2014-11-26" version="1">MHYFFLEKQSSLTQRWQVRQVAFDSKYRYLYYTKSLSRVDIEEVMTRSHEGDHTFAVSPNASSGTSSRKVKWSGKVKVTQLRYAADEYIVAPGSSDFDERILLTLVVVGYERPLQSHRYRGKVASSGSRSIGGTSEKSFSLWSSASRRRSTSHLSSVRLGDSDGDTDEDDALKTMGVNQPLLPSAEHEVPEPEPPSGFLHLPSYPVNESLDDGFEDEEENLFRDIDLVPDDDENDEETSATASEAETEEGSDDCDVDDGNDVALNSPPSTPTGSTRSGYSFFSRRQRNPAGGGNTKDEKMVQLQFRAANYEVFRIVSLRVRQALVRHGLCGPLHAGLPPYDPRNGIALATVPLHLRHAFRRLNDVVFYSLQIGHVVYVRQQREVRGMEGYLCITHDSILLLQLDGKCPRWLDLEDIVGVQYVLRSNHSFISIRAAEPYPDFVFIPIIPSYPPNSTFNSEECVEGIVSMVRRLLMQRLRAGEVVALAPVSSHSLSVQTAEDIDEYDALCHISDLSNTYTDVFKYIAQEQSTGAVPLRWRWGNSKTPSHFTFKRDLYHALEREDGEDSEDDDEAALSRSQRRPFVGSASASHVHMVESLVPSRQQQHLSTGGGVLVAPVAAPENHGAIYVRAAAPDTPFNASSCAAPQPLRSALPREDLCSNASFMPATMTQLMAPPSRVAELRAKKKLLVTRTDRRSASAAEAAVHASGGHLPPQAAGITAETGLGRSPEAAAAPQSTPAAASVVSAPPKGATLPTLPPRSSTSSRASAIGESLASPCPASQSDAQSASPMPVVTRSASSKPNTYGLIPSQHHPDPATLDFWFSMAAPPVAPVATAQKGLHLSDIHSSIQHGQLSTHQQLETPSTDTASGEQERLGVVPPAIQRGTSAAPAASTVKMTDGASRSVGSHLTLATASVGATPASYSFTSSPIGGGRLYGFTQRAQSPSAGHGDTATNRSCSPKEVSHTAENMSNNRASNEDEESDEDFDSEDMEDMLQRPESRAPPAAAGTTAPAAAAASGAAGGASSGVASSTAAADRKDGVVMRTDGAAFVPVDGGVVTQVVLTAEMLPGYGGDRDEDQRSDAASAPSPCLQALPEMAAFIPSAALHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RXP6</accession>
    <name>A0A088RXP6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sulfite exporter TauE/SafE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_320510</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO00938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701738.1">
        <property type="nucleotide sequence ID" value="XM_010703436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RXP6"/>
    <dbReference type="GeneID" id="22577792"/>
    <dbReference type="KEGG" id="lpan:LPMP_320510"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320009900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_320510"/>
    <dbReference type="eggNOG" id="ENOG502QWNB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="434519at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031464">
        <property type="term" value="C:Cul4A-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14255">
        <property type="entry name" value="CEREBLON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14255:SF3">
        <property type="entry name" value="SULFITE EXPORTER TAUE_SAFE FAMILY PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001839114" description="Sulfite exporter TauE/SafE" evidence="6">
        <location>
            <begin position="32"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="373"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO00938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="510" mass="55007" checksum="41F1DFF759580164" modified="2014-11-26" version="1">MSNMQRGRGVKRCTALGLALMAVLLLSNVTAAKTRCDFNTQRVQCGDLACDKKAQICIACRTDSDCYPDAMSCDMTSGKCKVRGFTSLFGARTIFTMLGTFLICSIGVIAGVGGGGILVPLFCGIMKIPMQFAVGMSQATICGQSTVSMYLIVQQKHPDSSWDRPLINYQYLSLILPLGLIGTLIGGILSKLCPDVLRLLLLFVILSAALYRTSVKVVKQYKQDTNAWQATVEADGENAASQQGNYGNNDERQGYELINRAVDAKSESRQGTTVLATSEHSLPAFENPPQSQYPQQELTMNFTCFLVLLLFNILRMYLVCGGLLYWLCVLIPLVFLSTVFYLNYEKLRKLVESDSAQVTFAWTQKNTVMYPMVAVIAGASAAMLGIGGGLVLGFVLNEVGLVPQQASATGGMTTLFIAFSSVLELLVTGHLVVDFGIVFCIVGLCSGSLGQFVFMEYIKGHGLNYLIIGSLAFVLGGSLVSLGGYGIYTTVISVHAGRSLMAFGHLCART</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYM0</accession>
    <name>A0A088RYM0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein kinase, putative</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_301750</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701200.1">
        <property type="nucleotide sequence ID" value="XM_010702898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYM0"/>
    <dbReference type="GeneID" id="22577228"/>
    <dbReference type="KEGG" id="lpan:LPMP_301750"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300021700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_301750"/>
    <dbReference type="eggNOG" id="KOG0663">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001558">
        <property type="entry name" value="Protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="82"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="297"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO00400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="621" mass="67067" checksum="016BBDF5EE5C850C" modified="2014-11-26" version="1">MSQMMQHHFFTGPGEAAATAMPPSDRGDVSPVWSIYDDYWCDVSQDAEVEDGEVGSYVGTTPRRLPFISDPVPFMTLKGSQLKKEAPIRRGAQGAVYSAFDAATITPAEDANAKNLLSHEVCREHECAEQVAGDGQRPARCGRHVAVKRIFIQASDFGAHDISATVLREVTLHRFVSDKQAACLAAASASYSTTSASSAAPRAEDDQGRALCDLIDDSARVVYLYRVVEAPHREMCLVMELAATNLEQAIFPHGARGASKRGMVGYRQKPGATSLFGTSASTGVGGGLSLSSVSPSTKPNTAAATEYPQGSSPSLPHSRMPLVRYLLRRLLRLVCFLHETCGVVHRDLKLSNVLVTKDAGLRLGDFGSARFIPPLRSDAKIQTQNSPSFTESHAAAASQREQLPCTPPSMRTTLHYRPPEVLLGDPACRTAADVWALGVIFAQLLLQKALFHSESELDLLGAIQKLLGVPAHCAPPSWLAAPSVPVPPVGGEFAAQVSVPQASFPYKFHAGVVPADGLDLLSRMLHQQPESRISARDALQHPFLNFEGRSAAATHDDDEQGRALWQERVTTVLREQTAGPIHGMGGERWPMFMRLADNSDEEDEEDDVIPLRVSLGGCTSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RYS4</accession>
    <name>A0A088RYS4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc-finger protein, conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_302320</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701255.1">
        <property type="nucleotide sequence ID" value="XM_010702953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RYS4"/>
    <dbReference type="GeneID" id="22577285"/>
    <dbReference type="KEGG" id="lpan:LPMP_302320"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300027500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_302320"/>
    <dbReference type="eggNOG" id="KOG2177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19756">
        <property type="entry name" value="Bbox2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15227">
        <property type="entry name" value="zf-C3HC4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="8"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="81"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="133"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO00455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="546" mass="61047" checksum="21F267C631E4BB3A" modified="2014-11-26" version="1">MSARVITCGICFNVLNQPLTLECNHSFCAKCIRIRLAESGNSGLQCPLCGTSHTELHSHNLAQYADHEAEVYVEMLSRDMPDRPTCQWCETTTAKVQCGECRCVYCEECSIAVHRNSAKRDHAIGKLSESSRNFMRRCQLRGHEEYRAEFFCSQCRQICCAYCLQVGPHRDHLHVTVAAAAAEARQQLSRDMQSLVEVKHRLEQQAAEMNRVSVLYTDTYDAVENTVTERFETFKQQLMQRELEVRRTLTKLRDSGDATLTASRQQYLDKLNNINATLLQFRSIQNSGTDDEVLQRHSQLGNCLNTDLPAVTGSGFKVVDLGEMTLTSLGIDLDLQTVEHNQHILPRLNRSARLKDASKMSINSGASVFSFAGNRLSMPLRLTFPVDDDVEATVLAEGVRLRCVARGGGATQIGVRSKEMFRTLLGQFPEDRGVVSWQVRLDSISDSFIGVVEKPSQAAQVPEGFYWKPTCAGVTDGRIGRYTSAVCHLPVCRNGDHVRFVYDGDEGSLRVVINDRDDCGVVVADLHPRIAACFIFYPSESLTVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZ57</accession>
    <name>A0A088RZ57_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_303580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701380.1">
        <property type="nucleotide sequence ID" value="XM_010703078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZ57"/>
    <dbReference type="GeneID" id="22577411"/>
    <dbReference type="KEGG" id="lpan:LPMP_303580"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300040800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_303580"/>
    <dbReference type="eggNOG" id="ENOG502SCRE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273287at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="367" mass="38726" checksum="906643582EAF2C9A" modified="2014-11-26" version="1">MEGPKKHEDASQRGITRHHVWRSKTGDFTVINLRDPSELLGIQEAPALTPPAETKQGAATSPPPPLRQSAARQMTGKQESLNALLAKLQLCRPVQESASQQPTVAKQTPTPTQSPASTVPPAAPSAAGSSALLPTARAPSPAAAMSEANDPSFPDPKESLSSPSGQFEFITGTNIPGQGVVKRTEAVDESSSMALFHDPLWGGSLDAFALPQLSKPSPKPQLRASLSELYASAASNNASAFASPRMPAPQLQEVTSPSATTVTASAMPTTMTSPTMPMMGGIIQPPTPPQLNTSYPMYTLPIQYMVQPPQFLTGMVYNAPNLFPYGATAMMMTQPQHIPHGYAIPTAAMVRPGTNVKAMPFVPGNKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZ99</accession>
    <name>A0A088RZ99_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_310180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701410.1">
        <property type="nucleotide sequence ID" value="XM_010703108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZ99"/>
    <dbReference type="GeneID" id="22577444"/>
    <dbReference type="KEGG" id="lpan:LPMP_310180"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310006800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_310180"/>
    <dbReference type="eggNOG" id="ENOG502SAI4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271240at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO00610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="157" mass="17672" checksum="A63D4B67E06A539A" modified="2014-11-26" version="1">METVLAFLEDTLLAQYVELLPSRWSALLPRLAKRTQQLQTLTDLTAVDGLVSALEDDFQHAAQLLHAEHGMYQEGVSLFDGLRQASELVQHTWRLLANDMLAELATKEMILAHWKAAMTTISADTLRVYGHAVLVHTRVTKPRVHHLIELARAAERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RZJ5</accession>
    <name>A0A088RZJ5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_310970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009400">
        <property type="protein sequence ID" value="AIO00685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701485.1">
        <property type="nucleotide sequence ID" value="XM_010703183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RZJ5"/>
    <dbReference type="GeneID" id="22577523"/>
    <dbReference type="KEGG" id="lpan:LPMP_310970"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_310016400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_310970"/>
    <dbReference type="eggNOG" id="ENOG502SRVV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268045at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO00685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="330" mass="34498" checksum="7C97DF98A93FC1E7" modified="2014-11-26" version="1">MHPSRTVRFETAASYMRISSRPSIRGVYFHSAAKTVAAAFANSGTSHAVPYKGTVVRPPSRGPASQPGARPSAVLSAAEVTIAMQLVAEKEEPAKTRASQTTDVANQSAAPATSNKVPALHLTPAHWEAACGADAAHPTANGSEAGGAKKTSGRRRGSAKAAWTEGGPQQQQRAKAVAQVAVNVTKAKKAANAAKKVQVEEEKCDTMKLTARPQDLLRKKATATKAARAAAKSEGWAAAVRKESLNRKSAKKISKATVAAKTEGAEHGATVYPRVEEQPVAAAAALAEPVCTHEKEDFAAEAEYAGPEVTDAEEMEPPEESTECRAELSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0L0</accession>
    <name>A0A088S0L0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_340960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702521.1">
        <property type="nucleotide sequence ID" value="XM_010704219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0L0"/>
    <dbReference type="GeneID" id="22578600"/>
    <dbReference type="KEGG" id="lpan:LPMP_340960"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340015400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_340960"/>
    <dbReference type="eggNOG" id="ENOG502S8CS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051252">
        <property type="term" value="P:regulation of RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000003">
        <property type="entry name" value="Zinc finger CCCH domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="92"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIO01721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="309" mass="35437" checksum="9AEADCE646272BF7" modified="2014-11-26" version="1">MASQSHMAMSKHTEAVAEHHKRIFQAAGDNNEEEKHILAGRYKTKLCKNYVAKGECPYDVRCMFAHGEEELRTTDDNIRDGLTTEEAIKGFQRQQNQAKRRAAFATGREHNSHDHHSSHSHIVRTASHRNGYEVEEASENDEVCRNHHRHHSLCLLRQHESVSTPQQQQQQQQQFQLQSVMTQCYTHNPYVFDLIPSAARLFPVYREMIEEGCWYEEESVPAPEDYYFPSSDMMMPLVPSLVTQQYPQYPHTQCGKQFETGASVSNYTGEEVMYGHCESSASSMYRSMARCTAAELPSNSDIPAMVMEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0M8</accession>
    <name>A0A088S0M8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Membrane transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_343320</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. MFSD6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01958.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702758.1">
        <property type="nucleotide sequence ID" value="XM_010704456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0M8"/>
    <dbReference type="GeneID" id="22578837"/>
    <dbReference type="KEGG" id="lpan:LPMP_343320"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330018800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_343320"/>
    <dbReference type="eggNOG" id="KOG3762">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="261787at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051717">
        <property type="entry name" value="MFS_MFSD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172:SF41">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIO01958.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="531" mass="57216" checksum="10632E0717BEDC43" modified="2026-01-28" version="2">MPPPSLLCGRCGGSESGSDSLSVDTCGSCASVTLAMVEPTMTDGSILISAPNSPSRSCVEADIHSAVFSTNISFAGGNSKTAVSTTATAVSAGPGRSTEAADPSDFTSGTPATAAATTVVVNVMPAIIGYFSSSFGSGICAFYSRIFQAKEFSPYEIGILISANPLLNMTLLPVLSYLADKFCCQTAMLFVCIVIATVSMFGHTIPDRRVPTISWFLVMTASRVSLSPLLDQRILMMFPKQERSNAWSYARSYAAYGLGIGSFVASLVFLYTVSWVAVTVQHLLGQIGLAYSMVVIKPYERTERVPVHFVEELKVLRTNKRLMLFLFSSTMMGAGCSFIDNFLGELGGSEVLMDFAASTEIPLFQMSARPHQTLTERRAMAIAMSVWAFRVVRYTTLTNTRAVLLIVPMRGVAFAFTWLPSLLVVSRAFPLGLPGGRIACAPRAVFPCPRRHPRGPPALPQSSRGRAISARARRRGAPADPAAAGGLPPAPRPPPPPSQRPGVRKQRRRHDERRIIRCRHGVCTIPHPRIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0T9</accession>
    <name>A0A088S0T9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable ubiquitin carboxyl-terminal hydrolase MINDY-4</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Probable deubiquitinating enzyme MINDY-4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LPMP_341900</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Probable hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MINDY deubiquitinase family. FAM188 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702616.1">
        <property type="nucleotide sequence ID" value="XM_010704314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0T9"/>
    <dbReference type="GeneID" id="22578695"/>
    <dbReference type="KEGG" id="lpan:LPMP_341900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340025000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_341900"/>
    <dbReference type="eggNOG" id="KOG2871">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10263628at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990380">
        <property type="term" value="F:K48-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025257">
        <property type="entry name" value="MINDY-3/4_CD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059022">
        <property type="entry name" value="MINDY4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039785">
        <property type="entry name" value="MINY3/4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12473">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE MINDY-4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12473:SF8">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE MINDY-4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26038">
        <property type="entry name" value="Dimer_MINDY4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13898">
        <property type="entry name" value="MINDY-3_4_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01174">
        <property type="entry name" value="DUF4205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Deubiquitinating enzyme MINDY-3/4 conserved" evidence="12">
        <location>
            <begin position="338"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="123"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="123"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="308"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIO01816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="706" mass="76603" checksum="7ADB9B1D94EC3965" modified="2014-11-26" version="1">MPPKKVKDFANAPVLKMAHGEQVQLLSDALLREYMHRRGFLATLKAFDDEHPRDENTISSRALMSDLMALNPDDQQRMKGEGIETIMEMLCNLRVERRLKTEKLTAEAHMPLPKLPAGYEALKKKQAERAARKVERQQQQKASLKKKLKASASPIKDGESQETSDTLQRKNSRHGKRHQRLSATSPSGASRGREPAGITMDDLLGSSHGSSDGDKDHDTPDEKEGEDRSSSASPIAEYAGARSAVTLSASGAGRSSSKQASAQSSQPAWMEVAARQKPPPMKGNGGDGGAQQRTFDDEGGYNNGAVDSEADEGSDKDADDFGGAAMTAAQRDQLSAAFQLLCGFDGSLHKAFLEQGFLFDDCANCALIQWQPSGCDGVIAPIQAFVAAYYYEREVYVGKEQRQRECLAKALCTSLEQAQPNVAKIVLLDSAWKAEPGCSRYMRSHALQQAAKPRTRCWTNMKSMQDVTQVVRDTLLTEARWMKPRGGGVASFLFSLLLSHGVDVVQQELTKASTAESGPPSLLLPTSGRATLGLVNFVLTGHAIFFRHNGVQNGNRVGYSSRLRCGLLCGDYAADSDRLDRASATNAASSSPFSYTNATEPQLPSWVLWHRDSFANLYMPKDTRQLFQQKLNLGGSASVDLVYWDAATEDDEFALTVTVHSAAFVPGSGSGGGARNAKSFVNTAITSVPAWSSAAIDWNGKAPLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S0Z4</accession>
    <name>A0A088S0Z4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Outer dynein arm docking complex, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">DC2</name>
        <name evidence="5" type="ORF">LPMP_323050</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701990.1">
        <property type="nucleotide sequence ID" value="XM_010703688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S0Z4"/>
    <dbReference type="GeneID" id="22578046"/>
    <dbReference type="KEGG" id="lpan:LPMP_323050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320036900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_323050"/>
    <dbReference type="eggNOG" id="ENOG502QSIU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6766775at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051876">
        <property type="entry name" value="ODA-DC/CCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049258">
        <property type="entry name" value="ODAD1_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21694">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21694:SF36">
        <property type="entry name" value="OUTER DYNEIN ARM DOCKING COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21773">
        <property type="entry name" value="ODAD1_CC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ODAD1 central coiled coil region" evidence="4">
        <location>
            <begin position="125"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="ODAD1 central coiled coil region" evidence="4">
        <location>
            <begin position="305"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="265"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="595"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="32"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="170"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="350"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="280"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO01190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="618" mass="70374" checksum="97DC5A1E664B4607" modified="2014-11-26" version="1">MSVVAATKKGAVADTLRRSQVAENIFSAQDQTMRQQEQIAHMTEENDQIKKEINSMSGAHYDYVKADKLASLQSDVDGLERRYQFEKMRKNDLTKRYQLARIDLLHSRRMKGGVNVEKEQAAAVQRQVDILESRLDQTLGQFNDALSYNKELRDRIDVIREERRVFLRVHKRMEDDLKAKKRLMAEHIEKSNRDMDDRDAQLREVERLRVALVEQRQAYTKQLHDLDTAMMDIKAMREEQTEMQLELEAREYEFEERMSDANVARAQEEADTSRRAMGASASSNGEEPTSTTCGEGHDGVQNVISVEKEAMSITSILAQIKDALQSDDIDGVRANYLHTGDLNFSMYKYVNELSAKKEALKDSIRDLQRLLSEEDDSERQHRALIKRLEEELAGTESKLDEMNYATLQLSDAVQRTAATAEDVYAHIGCPKMADDAVESEERCTEANMKQFLGRVEERATHILIAFQRHHQLSTYSRVSASSSLRAIRDPQLSKEAVQTLEEGEVALTANTTDSSHGEALQMAEGWEAEEVVPIMPVAPQTAHSAVSARSLVCMMELPSASLAGGTTDRDNNLYADQDDDHIVSHEDIRKQMEARLTTMREREERNQRKKKDATQKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S101</accession>
    <name>A0A088S101_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_343230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01949.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702749.1">
        <property type="nucleotide sequence ID" value="XM_010704447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S101"/>
    <dbReference type="GeneID" id="22578828"/>
    <dbReference type="KEGG" id="lpan:LPMP_343230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340038700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_343230"/>
    <dbReference type="eggNOG" id="ENOG502SD3Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273259at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO01949.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="350" mass="38549" checksum="D40D0257797D94CC" modified="2026-01-28" version="2">MTTPPFRDCTLRHPLPHSLSLSLRIAFSFLYSCEVGATRILPSLPLFYICLLVLKRRNPSQDGLRTFYAPSRDYLRPLSSFLFFFPIAMTLDFDVDDAPTFPELVRDARCDVMKGRAMSACWSELADQHTFFKDIAKEGRNRAETFAAVLAAVQGICQAVQRVDLFNSEVEVPSLACTSPFSSPAQGAAGGTWPGSRLEEAQTLAQVARAYLNLYCSTPIPTRAEWVSSLQFLFPQSLNAVSTEANDASAPCPDGDVDAVLTTPTSSTLGRYLTKLRQRVDGVLKELPESEVDGSDGSFVEDELRELLLCCMTVGRRVARATTLPSSDACLTREMVKALQDFVGSSTLEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S147</accession>
    <name>A0A088S147_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Biopterin transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BT1</name>
        <name evidence="9" type="ORF">LPMP_344980</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702918.1">
        <property type="nucleotide sequence ID" value="XM_010704616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S147"/>
    <dbReference type="GeneID" id="22579003"/>
    <dbReference type="KEGG" id="lpan:LPMP_344980"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340057700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_344980"/>
    <dbReference type="eggNOG" id="ENOG502SHAU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="754047at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039309">
        <property type="entry name" value="BT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004324">
        <property type="entry name" value="FBT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00788">
        <property type="entry name" value="fbt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585">
        <property type="entry name" value="FOLATE-BIOPTERIN TRANSPORTER 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585:SF51">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03092">
        <property type="entry name" value="BT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="486"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="524"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="566"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="607"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIO02118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="628" mass="68864" checksum="22915F1F0747E916" modified="2014-11-26" version="1">MSSRYHLSSAPDSSPAEAAKYVHPVSARVLHAAPFLGYIPVFSVTLRSFHPKFVLSICLQRLFEKGLANGLMRLSIQPVLTGRYGLTGAVYQRLSTLYSLGWAINAFITVMADTFALFGYTKRWYGVLSAVGGGVFALLYGLLPAKESSAKPAAIFMFLTALFMSNIDVFAVALYSEQIRCRPAAGPALVSWMWGTALIGIMISSIIQGPLSDNGLTHFGVYMTAAILLLSGLLFVFNLFEERRNCAARLEDAKVEFLQNAKNTSIDGTAGLPPSPQKRDAKLTADSNINEEDDEEEAAAMDARGFVRPHVDTYLCGAVEVNRDVMLRYWRMALFCLILTLGVIANVVVNIFGTRWDIMYACITVEVVVCVSSFFTLPLAVAKVVVFMYFNAILYVNLPGVLNTFYVAKPACLPDGPHFSYTFYNAMNGILGNIAGISGTMVFAHLFPNHSYRFVMSLSAVLLPAASMFDLIILKRWNLAIGIPDHAMYIFGDAIIYEACDMLLNMPMMMLMCRIAPCGAESMVFALLASIYHLGTSTSSAIGYLLMETIWPVVTTGTCDYSNAPWLVITGHIVTPVLIFPLAYVLLPSARISDHIDHTGRKVREVELSERSAEAAEEPVSIPTRPCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1J6</accession>
    <name>A0A088S1J6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL29m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_040240</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="AIN95351.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_010705371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1J6"/>
    <dbReference type="GeneID" id="22571983"/>
    <dbReference type="KEGG" id="lpan:LPMP_040240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040008200"/>
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    <dbReference type="eggNOG" id="KOG3331">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270763at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MRP-L47_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010729">
        <property type="entry name" value="Ribosomal_uL29_mit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21183:SF18">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21183">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06984">
        <property type="entry name" value="MRP-L47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN95351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="480" mass="54165" checksum="44F71E5B5073E45A" modified="2014-11-26" version="1">MRRSARRANVAALYEFVDGNFLNNKRPAIPGGAWPLECLRRKSLADLQQVWLSLLKERNMLSTIREHYLKHQEELGAMPAPSRLKMVEDSMENVKRVVKERDAEATAEAVRIFQERLAKGIYRYPPGPPPPPGAHCSMCTVKLVLSRRVDEERLRELLGRFDVFEEHKGIVALTMQLPEEVLAKKRDAEQLWQQYMTERRDVEEYYKWPGSSTGGAESASVYDYTVVELAPGVYSGHRGTSAAESNGKDDGNAVAHDVVQAAQLPVPPPKTRPPPPRSPLEHIKYQQRSVLSKAVIQLGYFPNITTTPPQFTKVDDVPRPVHPDEIEGPWEVRVTYDAKDGLAYVQSLGLTSIDGAVVLSVEEEVPATAQPYAAVDPVYQEAVRREMAQEETLMKWPNVPEWKYQYDLYTKKNLAQVVQYNYSNVVDYIDREVLLTGRSVWESPIDIDPTCGGMKSVPAHAKKPKRYMTHGLSEVGVTDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S1S1</accession>
    <name>A0A088S1S1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_345170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO02136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702936.1">
        <property type="nucleotide sequence ID" value="XM_010704634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S1S1"/>
    <dbReference type="GeneID" id="22579022"/>
    <dbReference type="KEGG" id="lpan:LPMP_345170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340059900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_345170"/>
    <dbReference type="eggNOG" id="ENOG502RX9F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="257"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="346" mass="38760" checksum="322B86144BE7083A" modified="2014-11-26" version="1">MPSCAIVNDLADFSPLEYMQRAVKNSDCRTPIIFVQQDGDPFQSVCYLAKQCDSAVWSFDVAQLQSAQNIMDYIDVGINNGDWVYVTNCDLVDESYFRDVARTLYQILPEPHRYPRREVFRCFFGVTVPFDLNAPVGLPFPLLFMHTALVSRPTAAPGSKWSRIMPADKPLFSVAALKHQQRREAGRESDSESDLDETDRISGVIFLRAAERNRGIGQSVVTLAKHQMVQAIDEQDDGLIRRLVSSGEVDLSRKLKDGMTPFQYACCKELTESVRTLLLVGADPNAPREADGRPPLFMAIDDMELAKVLVEGGANLFSKFEGYRADTHPDTAPDVAAYLGEERKYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2C0</accession>
    <name>A0A088S2C0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_352290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703166.1">
        <property type="nucleotide sequence ID" value="XM_010704864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2C0"/>
    <dbReference type="GeneID" id="22579258"/>
    <dbReference type="KEGG" id="lpan:LPMP_352290"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350029000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_352290"/>
    <dbReference type="eggNOG" id="ENOG502SK5G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266608at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="633" mass="67570" checksum="29359510A6B3B984" modified="2014-11-26" version="1">MEALFYDHAAISTATRQADLRQAMQAFLVDTASRSAVQLIALLVRIPTPSTVSVATDSVSGSRTTSSTCASQEGGAVTTRDAATGEAAAAAPRRSRTVQKLAWCAWEADRRLRQAAEDAAEINMWIAHGEFSASLKPSARLTRPSISSPFVVTAAFLAPYTRGDLVVYESWQRCAEVCTEAPVASVARGSVSRTTRTVSPLHRASLIALSLGAPSLLLSWAERPTRCHLDSLLLPHQTLLLDLSWWLAAASGSVGTANDTAAGSRVSNSVLRDIFINDVHPSLKLPKGDSRCAVWISYATILASLHPQVMGRSEGANGDNGNVDVRVAGSASQRGRGWNTLCGDVSGVDEQAFMKTYALIRHLLSSLNASHSGAVGRTHFLRTVLSYGGPSSALRRQLVHTCSRAAHGVMATDAALLRTRSLVDVHALFGVLAGQDKVNMYSEAAAFVRTARRRASAGPELQQRRQRSAVQSAWVQVASSPSPGTEQKAVARVSTSVRDNAFVDRGARALARKLRLWERKRLGKGGKRGVHVRPRDKAAKRTMKRVHAEAGGADSERFLMHAVERASRAAANHRAGKKRGAEPLVGGDGCPSASTTRVALRPQKQRRTNAATVSVGLTTDTALSWCEDATGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2P8</accession>
    <name>A0A088S2P8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_353590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703296.1">
        <property type="nucleotide sequence ID" value="XM_010704994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2P8"/>
    <dbReference type="GeneID" id="22579388"/>
    <dbReference type="KEGG" id="lpan:LPMP_353590"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350043800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_353590"/>
    <dbReference type="eggNOG" id="ENOG502SDJ7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266126at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="59"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="183" mass="20011" checksum="1473F6FE7E809623" modified="2014-11-26" version="1">MLSSSSAGAAVKSNTGALTAALTTVKADEDPNVEVLWASKCIHKLTRATDALIARDFVLREEEAILDDLETYLASLEDEVKKSELQTEELRSRTSLLRPDKRRAVVGENAEVSALWKEYGNAMGRLVKQHSLRLEELEKALSTVSARDPEFPLPEPLQPPPVVKVSSTMAALLDVSKGQKVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2V3</accession>
    <name>A0A088S2V3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_355620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703493.1">
        <property type="nucleotide sequence ID" value="XM_010705191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2V3"/>
    <dbReference type="GeneID" id="22579590"/>
    <dbReference type="KEGG" id="lpan:LPMP_355620"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350064900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_355620"/>
    <dbReference type="eggNOG" id="ENOG502SIIE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265734at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO02693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="295" mass="32436" checksum="BB5BD16141DAF418" modified="2014-11-26" version="1">MQEERPPSSLTAAVPAGRIIARLSATLRQTEQACAEVSSIEGLLCSLSAGVEDLTRTSAMSVDTRTTKSSLERRNADELTMEVHVPPQPTDGSSPYNWVDRRTLCSALEGSNVFHRSGLSTTFSALERSVSNAMAFELFPKLQRVTDKVRQLCSIVDERAQKAQQRQSLPHARAEWMCEAVRALHRIAHASLESEDAEATKPSVTAPCIPPPSPQQAMGIVQKSHVFPTPSDAIWWELYAGLQGVLHRTALSSASTALGKSEEVAESRLELQRQRLLSLLEEMTMWLVEDTSATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2W3</accession>
    <name>A0A088S2W3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNaJ family chaperone, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_342940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="AIO01920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702720.1">
        <property type="nucleotide sequence ID" value="XM_010704418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2W3"/>
    <dbReference type="GeneID" id="22578799"/>
    <dbReference type="KEGG" id="lpan:LPMP_342940"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_340035700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_342940"/>
    <dbReference type="eggNOG" id="ENOG502RXA9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051948">
        <property type="entry name" value="Hsp70_co-chaperone_J-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44360">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44360:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="20"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO01920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="428" mass="49008" checksum="223D8B9DCD2B54FD" modified="2014-11-26" version="1">MFRRALLCLATPSDPSRLLSPHQVLGVAPGTPFEEVRQRFYELTKKYHPDVEHGDPIKFREINAAYRLLRAEYRQSSSGRSARDEERGPSSSGFRQAKKSETPTGGAFWAERNERVRKANEQRERERWAAEDRDRRQQGVKRSFFHELVAFLKGSEIAISIGTVVLVLLYSVERYHTINCMLTEKRRRLKNMDEGLPPSMPLEVDKALSEKYSALPDSREQQIDALRIREESYYRRATQRKFEDFREFMFVYDPEAVASRKVVSTRFSHQYMREAEISKRCPILREFNSESRTHHYGAIEKELEQAIREAPWSAPDAGYAGALVAKGLSCIAANSPSTTKWTFIEYTDMDKGSTKANTTCLAALRNLRFGQTGMCQRVIVTGKSELQPRLVAQRERDLMEGALQKRSLLTGGALPVKDLSVPLESMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2X8</accession>
    <name>A0A088S2X8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Leucine-rich repeat protein (LRRP)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_355930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703523.1">
        <property type="nucleotide sequence ID" value="XM_010705221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2X8"/>
    <dbReference type="GeneID" id="22579621"/>
    <dbReference type="KEGG" id="lpan:LPMP_355930"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350067800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_355930"/>
    <dbReference type="eggNOG" id="ENOG502SA73">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="433501at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050836">
        <property type="entry name" value="SDS22/Internalin_LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652:SF3">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO02723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="28461" checksum="1F6D839072C6E3FA" modified="2014-11-26" version="1">MMLKRGAETSLMEDDCLTSSQQYDPHLLFHVSIRRKGYETIGANAFLRCCALRVLDVSGNKLSTLSGLESVAPQLTFLNAAENSLQDISALVKCTALERCMLEGNQLHSFASLEPLVSLPCLVELVLQRHVPFDDVGMALGSSQQCSSRLLLLDNPICRDVVAYKQQFLARVSHVRWVDGALAHLRARSLAENATNVLNDATEHSSTSIVEAAVASFQSIRVQMTTTVKEETELRCQLERYADRCKKKKPKHSNQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S2Z4</accession>
    <name>A0A088S2Z4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alternative oxidase</fullName>
            <ecNumber evidence="12">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LPMP_354490</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="12">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the alternative oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="12"/>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703381.1">
        <property type="nucleotide sequence ID" value="XM_010705079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S2Z4"/>
    <dbReference type="GeneID" id="22579477"/>
    <dbReference type="KEGG" id="lpan:LPMP_354490"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350053100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_354490"/>
    <dbReference type="eggNOG" id="ENOG502R8NB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="16906at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098803">
        <property type="term" value="C:respiratory chain complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009916">
        <property type="term" value="F:alternative oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010230">
        <property type="term" value="P:alternative respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.140">
        <property type="entry name" value="Alternative oxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002680">
        <property type="entry name" value="AOX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038659">
        <property type="entry name" value="AOX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803:SF33">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01786">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIO02581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="486" mass="52929" checksum="AE1760DC21BD15AF" modified="2014-11-26" version="1">MRMSIRSNVCIPSAALSCHRRFTFNDSGHGGVRRTTLRTTSFAGSSASKSVLSPNAFASSTVRSKHPSYLYHFFMGHSTRFAAMAPPLTRAGITQLEREPLTHSTPGRINDHICIGMVKTLRWLADRVFRERYIHRATMLVTVAAAAPAAGSVAAYLRMHFKRRHSSNTGSDGAHTCDAAEGSSPFLAFGSSPNTGGASSIPGASRSFATARPSLCRSTASAATEGARSTLEHSYGKELRGLFAQCESHSVHYQVLSCMAEITLAERGLVLLLQAIHFTIYLALFLFYPRMGFRLMAYTAEESSVVWTQMVNDVDLGKIAEMCVPQLALQYWGLEEAFTTQVAPVPMAVTSEEQEQVLYKTSDEGVEEQVSFADTAKSGISPHGVDARNRTVTSPSPAVDHVSAPFTVACSRSESDVDTKESEGHIIIASELGAGFAASVLTLRDVALLIRSDEMVFRDLNHELANKLDTQPSWLQRLVDFYGSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S310</accession>
    <name>A0A088S310_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_080470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="AIN95856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704178.1">
        <property type="nucleotide sequence ID" value="XM_010705876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S310"/>
    <dbReference type="GeneID" id="22572509"/>
    <dbReference type="KEGG" id="lpan:LPMP_080470"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_080009700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_080470"/>
    <dbReference type="eggNOG" id="ENOG502SMRV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272610at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039964">
        <property type="entry name" value="KIAA0040-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40382">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40382:SF1">
        <property type="entry name" value="RIKEN CDNA 4930523C07 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="290" mass="32092" checksum="682038BB833072F1" modified="2014-11-26" version="1">MRTVTRSPLLVAAVVVATTLCFTNDKSLLSLSGVWLARADGPITREECYILNPHPTVISCSAYLPPILDLYGVLPYDTTPAYMTCVKERCICTGAATSMNITTSGIYCNSSGWMESGYTTCNVLNDCFAKFWKCMNHALYTRYVNERQSLSTAEVDIMADILSHGSRPSEPFDITDVYRSCRLAMCTAADSRQNCGLVTCLPNYTQCDEYIRPPPQPYMRQRCTQGCRAALLLMALTIAVVSFSMCCCCCCPAPVRITEPLIMVEPEKKLKSSSTYGHQGEQRSVADPFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S3F2</accession>
    <name>A0A088S3F2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tyrosine specific protein phosphatase, putative</fullName>
            <ecNumber evidence="4">3.1.3.48</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_355500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.48" evidence="4"/>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703481.1">
        <property type="nucleotide sequence ID" value="XM_010705179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S3F2"/>
    <dbReference type="GeneID" id="22579578"/>
    <dbReference type="KEGG" id="lpan:LPMP_355500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350028800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_355500"/>
    <dbReference type="eggNOG" id="KOG0789">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF449">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="31"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="212"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="450"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIO02681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="499" mass="56220" checksum="023A163421384E6B" modified="2014-11-26" version="1">MHKRLRKEKQRFDAHLRRLGERVYPTLEDGFDRELAKLRRVDEHVRSNLDEYYSASLGSSMVKNRFPNVKPNEGTIVHLNEASFQGDGAYINANYVDAREKFSVPFVYIATQSPMKNTVLDFWRMVYENDSAFIVMLCAVEENGKIKSETYWPLRGETYDMGMLTVTHVAESMQQNSVHRCLLLRNVRGDEKEVLHIQYLTWPDQGVPQSSVTLMEMINSIAKSPRSTRSPIVVHCSGGVGRTGVFIGLHIALAQFQLGLVNISIPHIVGYLKTCRSGMVGRRDQYIFLYYAVQREMERMILSQKAGINLLDSRPRLATPAVTRADPAPTPMTSPLIMPIPVPARGWHRTSIFTLFRSSKSVRPTDLRSASIRTPKHRNIEADVVAMENYLQRAGSSPCSGRSPNMSHTGNRSSPMEALHHACRQTSFSSKSLFIPVPHEPNMHCRQVGTSRSSTSHTSETTTPVFRSTSLLQEELARLQQVNRVKRFSPSLACGIGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S4H9</accession>
    <name>A0A088S4H9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Integral membrane bound transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_120580</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009381">
        <property type="protein sequence ID" value="AIN96386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697039.1">
        <property type="nucleotide sequence ID" value="XM_010698737.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22573064"/>
    <dbReference type="KEGG" id="lpan:LPMP_120580"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_120010400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_120580"/>
    <dbReference type="eggNOG" id="ENOG502RSIY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="251552at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30509:SF9">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN MDTO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30509">
        <property type="entry name" value="P-HYDROXYBENZOIC ACID EFFLUX PUMP SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="763"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="807"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="835"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="858"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="889"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="8">
        <location>
            <begin position="775"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="59"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="260"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1116"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1319"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1402"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1637"/>
            <end position="1738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="260"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1147"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1171"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1183"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1344"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1423"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1660"/>
            <end position="1723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN96386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1852" mass="200135" checksum="CC35EB387DB414FC" modified="2014-11-26" version="1">MSAVERIKESRNGEGFSMCDPVLPYDQSKLGMQARRIAAQGMLTAGKLRALEVQQAGGRFGGTDRGYPQQPVAQSISGSSARPSPYSTRYPSTSGNTPVSMAYDKGFSASPQHYGRTPSEQLTWRRGGYVRSVAGGSQSMGGGRQAVTASPTLRVITTSETVTGGGVGNTSMNNTSGSASFRTRAASGGILSSPGSVDSKPSVAEQKLSNFFQGKSQQTINKNLYAMESSSGGVAESSAWSGGAAVSLCGTVNHKGAAGGGGGGGGGGGGSSGSPSSKGGHRKMVKVPHSDDEKNRGYKWEDPKKKMVTEGDDDEQDERNSRTRNIDALHAIPWDQRQQLPVSGFGTRFFALLNTPRFWEKLDWAVRASLLTVLPTMVLSLEPSTSPMFPLPSSLAFNAFWITMPTFGSGLRELMIALKGFSFGLLFLCIIVGTHPGPSWESLLLLFFFTLISSFVAEETKKTAAYVLASTIMQYIVDPVGTNFDYIRQYYIGLLIGLAFGTAGFLVPFIRWSSDIARHYIKAMGNSLSIDLQGTLSSFWVRTPLERELNVVRLRQLRATAEKCLSKIETALEESAYEPHTGAYMTCMVNRFNFCKSIHNILGSLSHVIELIADNPSLIDTPMCTTFGEQIGDDLAVISSAMDSMVLKIVDFARIVTPQEIQFFREARQRFQDALSRVREDVILTNENYETDESDVLLGFFMFSVDEMCEVISQFEETAHPPNTLWNAMLFPVRDVKSVIAAFRNLGITVVRRRTIPRRMKEAIKLSLCIVLPCIFQVYALDNDSVSPAAGAAVIALIYNPTGSESFHYASGRLLGTVLGSLGALLSVQVASSRLWVLYIFITILSFIGAYVQSAPGFYALGNAIVSSTISVCTQYQNGNAAMVRIQQNCFAILMYFAIACTLWPMHARTKVRMSLNITLRCMREAITRMLRNLDMPYDANEVTADVSALLIEMHKKVRTQSRFIPGAVEEPTMGSVEYPEDSWKRIVEAEKKLCLALSMMCFAYNTFMSGRADSTTELSVHWVVLHRIAPHAQDLSDLIYASIDLYLLSLSKMTIVPTSHITRLRVGMVDAHQAILETYMATISRKVAGEQDVGEEGKEEDMYGSNSYMNDEEYYDYGGSPHLPPTRQARSYMKNINGDGGSAAGVDDKPSGRDGDHPAPPQQRPQRQQSEYDHGHDRGNHSSGDSMDSSSSENAECDGNGNKRPHKRTAKGDDGKKKVGYLSYELTAEEAAALRAFVANRVSNATFGSRKSMMVNNATFSGQPASGVSAAATAAAAAVLGARGSITMSGSPPHGNNDARLMAVTGNDDGLAASLRKKHKVMVKRGKGEENDGDVEGPPGSEGSHDEEKAKGGRSDADNAPGTFLSNASFLNSSFRNASLLGSLFARKTKGPRDLDTVEMQQLRAGRSRGSRSTSSNSKGEFKKKKRQRHLSSKRCEESDGDGSGESISQHSTPLTLPTHHSHLGIVGSDFSDIEDDPKPLLRRRLSTKVIRLSETGVDPKDAKVNECLPMAHSVPVEIPGGNGSVLNPLAEDSGACEGAAGAEGNPLPMPQPSSMASGRDSGAELVAVHRSVDSAGTSLQQASNLTAEQLCTVAEATPGTLFSGDDPAMAAASLNNSGGAATIVAHDLSQFPRLPQCSNNVTPEDHKDSPPRTCGGAEEEKKKCEDRDRTRHISSNEKAVPDRDGEETAHNRTGENQPHGRSDDTPGKDGRAPDKTVENQKDASGAVVRDDQLLNNNTTTHRSLATLVMHPPSGMGRGSLDSEGNCQRAAVMLNPTCDGDGTSVTPSEDGEILNNLSFFDADKGEFVLTNHDIHSLEAFLFGTRALIVYINDMQKALLEMQHATDLARWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S6T1</accession>
    <name>A0A088S6T1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein 135 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_180600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697894.1">
        <property type="nucleotide sequence ID" value="XM_010699592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S6T1"/>
    <dbReference type="GeneID" id="22573950"/>
    <dbReference type="KEGG" id="lpan:LPMP_180600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180009300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_180600"/>
    <dbReference type="eggNOG" id="KOG1398">
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    </dbReference>
    <dbReference type="OrthoDB" id="291792at2759"/>
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        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026749">
        <property type="entry name" value="Tmem135"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459:SF15">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="467"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="53537" checksum="888B92377E0850FD" modified="2014-11-26" version="1">MQELGSPSTSESREIQHCKHYSLKHTMKVVIRNSIYAAIGRILIGVMKALVKRGVSRAFLARIPSEFLSLDPLKWATVFAGFSSFRFCRQTLLRTLKPFGASEKFVSLLAGCISATPAFVMNKETRTELCLYLFVRSAHTFSQRHLLPRMPKVVQEFYYYDVVLMCLSSAQIGYGTLFNPNTLPKSYQGFLNRISTYHEKLIRGHSGFCRERLIPDLVDYCWSKKLPVIENFGQRGANILCQVAHSGYSCNMWAVVFIVKNILTIGMPLYGPQRLVSMLVFQRRRLMTNPVSTITHNVRSMLISSLVLALYIGVILRSACFGVQHRGGGTKTVTALCSLAGVATLLEPKRRRMDLALYCSMQALRSFLLTQNLRGRLPYPRHWFVCTVYLLSVGFLFYQYEEEPRLLDRRVRTALHLLLDEPSPAVSKEETSPFTSAAVSTGDSAGADAPAESPTAGKTKEKPEVASTVSIGSTRQGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S889</accession>
    <name>A0A088S889_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_203110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698513.1">
        <property type="nucleotide sequence ID" value="XM_010700211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S889"/>
    <dbReference type="GeneID" id="22574522"/>
    <dbReference type="KEGG" id="lpan:LPMP_203110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200037000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_203110"/>
    <dbReference type="eggNOG" id="ENOG502SEDT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="261641at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="613" mass="67914" checksum="C1B77BC9A0E7101D" modified="2014-11-26" version="1">MLNRYQAVVNRKLSQEGYYDAVRHLLPISAHRNLLNSSYTPIINFLQECLLNPRSQWAIQSSLVWDQLGVTYAVPFAGRLFAVDPARPVTALVAFEDANRYVEMASERCRTLNSLLTTGASLNVVRRAAATTASPPLAASEHTAAKSATSTVTLASSAATSAEGKQWEAFETIGLRREVFGDMSPAEIEFWKYILRLQQSPSQIHDISFHLEFGPHHMDLKENGRFIPVTRLNLNQFIEAVVAKQDEVHTYISEVASGTPTHSNASREAGRGSEGSADRSAPRVASTTPTTPQMPTTQQHVKIPVKPPTRTVGPEATSVLGHPQRGVHRGNEVHLTLRDVDSTVVRSIKELRSQFQLGRLTKTELNARQLRFCLPCRDGVYNLIPNGRHIQVATGNIGIFLQYIEEERRRVEALSRSGAENPAGHVGLHSSEAVACGIRSLNAMQRDEERGPDTVDFADADAGYWTDKNVLDIWTYECTTDCLLKSSMSPEEIVRQTQLQWDTNFLSSKDSPYTDASAIGCVILPKDVKTYLRLLRRRLQSIRLAILDAGKCPQQPSEWDSAEWAEVSLPAPPVLSTIQADVHLLPPMHDNLNIFSPTYNTGDLLAPPQSLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088S8Z0</accession>
    <name>A0A088S8Z0_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_210200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698808.1">
        <property type="nucleotide sequence ID" value="XM_010700506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088S8Z0"/>
    <dbReference type="GeneID" id="22574842"/>
    <dbReference type="KEGG" id="lpan:LPMP_210200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210006700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_210200"/>
    <dbReference type="eggNOG" id="ENOG502S0G8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="487"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="491"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN98101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="720" mass="78411" checksum="BCE3EF992515A05D" modified="2014-11-26" version="1">MGAAQTSVEGLLNQVRQQAATSPVWSIDLSALLERCSTVGGHSPPSQEQLLCRVAATLASVLSAVEAPSVAALSVTLPTPGAAMTVLQLCRTTPLLSSLESLELVVDTAAVNTLQNSMESSGGHEVAALLRELAAYQRRNAGQSCWTSLSVRSRDTSAPSVLTVSSHAQQQRRAVQRMWDDTMVSALSELVATAPWTRVALCHIDLTPCSFRTRQRLWASLDSVHASLTLLDLTGMRHAHEFIASRQLCHLIRLSYLDFSHTQLSEDAVQRLLRDVQDGVGGWWLLQHLGLAQCEVSEAVALLLHNQHEQHAKGEAPLLESLNVSGARLSCRAAFVMAMCLVQCPRLRHLQTRHCRLQPASVEDMAAGLQHATELQTWVLCFNKFGDEGVAALTKYARCWPSLTDMDLSRCRLTCASVHALSRALPEWNKLQSLRLVGNDLRWQPPQALSSSSSSGVESSRNGRDTSGLFAYDPAYMKTHGSSVKVPTSYELERRDRKEGRQRYKGTEELAEETVPVAPPLEALGEALSMCSQLRVLDLSDCAMADAQLVQLSTHFTGASLEELRLASNPLFATVPALDALVEVLWRTPNLSLLDLSFTALGDLGVSMMCDGTAGVDSGVLKAMPGLHTLLLSGCAVESLGWESLAAAVSQLTSLRHIALHHNRVSELALLEELLRQLVTVSTLRSVNLAWCVDSTEVVRRLQDCAECRALRKRGVQVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SC77</accession>
    <name>A0A088SC77_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclic nucleotide-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_261840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700003.1">
        <property type="nucleotide sequence ID" value="XM_010701701.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22576087"/>
    <dbReference type="KEGG" id="lpan:LPMP_261840"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260023000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_261840"/>
    <dbReference type="eggNOG" id="ENOG502RRH1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273687at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF15">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="529"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="831"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1155"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1478"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1576"/>
            <end position="1671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1968"/>
            <end position="2030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2171"/>
            <end position="2190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2469"/>
            <end position="2489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="658"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1166"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1489"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1500"/>
            <end position="1511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1596"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1633"/>
            <end position="1646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2480"/>
            <end position="2489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2566" mass="271998" checksum="9F7F5A647622ECAA" modified="2014-11-26" version="1">MQPERRDLALRRGHGEVAEEAEVVAGVTRSSSHAPAHHAEAEEDDEVGGSTETIAIGHLTLRSFTEEYSRFSTEGTVGWVGLQTHLRCHTQSSQIFTLDLTCCHMRRDQWTWFTQDILPQLRVLEVLHLVQMHLEDEAVVELVRGSCGLSAAADGRRTASRSWQQSPSSESLHGCGGSGDGSGSDGRTMPSAPLAHLRVLDLSGNAVTQRSCTHLGKMMLWMAGTLEEVRLLGNPLKDYGMQTLSVYVSKLNLETLEQDSSLFPAALRELCAQVRQTCRRGHAERSGVSGVASSSAQSAAAAGVVHAGRSEDEGRGDASDLVAGLPLGPVLLDLRDCRASVRGLSEMLAAASRAHRLRTLVLSHNVAGVTSLLPLPASEYHGAANLAKEEEEVVSEEREARPRCSADRGPQPQPQPLPLPHRLRLVKTPLVYSGALMRRKLTAFSDMAVFTTSCALSTLVLYGVPLSQTCSPLGFRELLLNIFFSCPLLDLVDLSDTFEWSLLPPEARLALLTEGNRRDAVEQRLHGLEGRQGLHVYGENEGEVEFRLDSAVVSGQTRLGDIFGELMAHAALNAVVRQRLLPAAFLHVRELHLSSTGLTDAGARGLCMSVRRGRTHTGMLASLVVLNLSDNLMTVRGCVRVISTFLLDDDAKGDVDATRSSPASPGTATATRGPMRIAPLTALALQRNAGIESSRSDGTAAGMNGGSNDGADNAEYLQQVCTAAEKAVLRRATLRSAACLNQACRSSSTETRNAATQEEQVPSLTVYFSAPPPWAATRPMSSSVVGDPRPPSTFLSSAASMDVFYAGCDYQGDAYCTCPCSRFYVPKPASAEATHREDPNGAGLPYSSQQQQWTSAAASRILAGAATARGGQAVSTLAVPEAIRSDSGALSVGVTPTTGVKQQNHTPAGPRRSLFASLDAPRDAVASAMTAAAVGARAGGECSNGPVNTTSLHHLWNCTNDMAATTAISLASVSSSSFSFAPTLPSASMSAAAATRHTSDLGAADADRRFMLLQQQQQAGQPSRRESNFSVSGGASFGELFMSKSEETLPLTLGAPNSIEFSDAAAAAPMGVDVDMSSTLASTTVSAKHTGGRRARLWRTRTFVLSYDHPAGHLLCRALGVLLRPAPDAVGEGARAALDKDLLDALKRALAAFTARSTSEQDNDEGGGGGGGGAGKAASTTVVEVVHYLPPESSSATVADGGDPNQREAEAHWMRFKVTTNERKGVIAQLLQEVLNVPLSEQRACFERLLQFVGQHVKCGEELDSEPSAEDLWDPVRAIERAARSSAAVRARLEIAYGGDAATAVHTRHQYYDAADATLAPISDAGGGAAAAPGAELNGTDNTEGVVRLDHLYSALWKELGLPVSGTARDALPHAPASLCIKEEEAEAPVSGDRRPQLLDRRASGGDLYMFPPTSCDATSRRSSEAAIPLSVPPSAAVHQQRLHVVNLYDRGSSELKLREWESLPALLREGQRDDAFASAAATGDDQGDMERAEDDRETSAGSASVTTPEKQLSYARDMELGGTAAELLPPLFALGDSNAEAPQQGSPPVGVALTDQLMRLSPPLETCNTAGAAVAPSFSQQQQQQVPRASLAAAEDEKGQQHMDDDSGESDMPRVVTSRLRIGQQSGEERSGSSGEAGSSVGGCSAMLSRPQQELSEGRQHTQPGLAHPGVTGVQAEEAEGEEDIVIAPPIRVQRRSSQLVGRIKTFTLSYTHQEGTAVCRAWRLLHSAMHVYRSKSANSNSASCDASVDVVAPISPPASLSLSVLAKEAQKCLCDDFLAFLQPPDEDIEHGVLSVSLNCDSSVATAMLQVQVQTNERRAALADRLQHSNHGVRRSVGRDHRSGLVPLSVQEVDRFYFPRLTHLLRQYKTVADMVVQVQTFLQPRAALQDRLLQSYGSIAALVHYYHGSSAALEHELGISSWQVLMDPTPLGTARAQQLADDVLSPTVAVDRVQRRRNVVAEEGYQGGGALCEGKPRTPNPQPQPATAGAPQLSRLASANDGASGATNLQGRPPPHPRRLPTPPHAITHTSSISFDEVTEDSTSEEGPVVVLRCTTPTKTSHSPSTPKSFHVQYTSGMHQQVFSTTSPPRPVVEGVSERGALNESGDYLDAGTDTGLVSPLTAISSTAGSPSQQHLGLSLEHPAATGAVAPSENSLSTQPVPHLLLQPAGDKDAAAAPPGAKSGCDSRQYHYSEASGSATTAAVPVSSSSPLVMSAPKTKTIVGSSTGGSLAPPFQQLAEYNHSNAGGNSNATLQPPQVNPRRLVAAAGARDSSSVTGLDQCKSEYERVLQGKYKRLMRVAYDGVVRGSVPLDPQHQQKTVIGRGKWGAQKVELSLEWEILFVLTFEKSRKLGRSSRRAQMLVHPVGCGFECAAGDDLSRTASSGIFCGGDAPSPQSSAISGELGDCGHHPSMMPMSKMPRKKEPSRSAASHLIITIQRPFTPDEVGSSSHNMEETVMAGALLTVSSSKPGRLLGGGSDDTSNTSRASVGANQAVQEYVFQLCQPSLTLVIEMKSSKHVQEALRLLKNSIRRATQAVNKSMLNAQIPPPVLTSSSLPVGHHGPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SE04</accession>
    <name>A0A088SE04_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_290360</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIN99986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700929.1">
        <property type="nucleotide sequence ID" value="XM_010702627.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22576800"/>
    <dbReference type="KEGG" id="lpan:LPMP_290360"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290008800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_290360"/>
    <dbReference type="eggNOG" id="KOG0606">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="352"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="36"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="124"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="267"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="505"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="901"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="999"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1165"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1378"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="298"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="901"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="928"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="965"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1010"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1202"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1221"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1378"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1409"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="666"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="381"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="684"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="8">
        <location>
            <position position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN99986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1435" mass="153866" checksum="4B1E4CBFA30AA5C6" modified="2014-11-26" version="1">MVVSTERAALIARLSGFHDFALRLPGFSIEDRAVSSAVGSKGGNDDVGHKRCQSPEQPQPPEPPLALPPPQQPSGNPRRPAVLFPVPLVPAQQCKAVRSPKPYDASMAREVGNTSVMSVLSVMSRRHSNDEGSSERNRDGMEGEKERPSTAPTAEPPRVNDTSRCFNPTPDTEAPPGVTAVFQRYLEQTRRMILYADSSEADRAVELDGLLMRFHELFDLVRDMYAVVYVQGIAIDRKRLSMVKVLPYDEVSTSSASEGSYKVSPFTSTSVSSTSRAPEKAVLKTRGGTGSTKGALLSSKTQPSNSQLPPLSWRPLAAVTAARSQDAFERGRRTSASSCSSSVACIEVLNNYYVTRLIGVGATGRVHLAVDKQTCKTFAIKTVPRHSRKAVGRRFPLASMSTSDSEGQQLGRPRLGAVDVDGAAAYAGDNTTSNTPPTLVRPFSMAVASARPLMRQGNAGDSMDACLRDAALESLIQVPTVTRPSDTVIPLVENVTAAFSAMVSGSGNGEAPCTTKRSTSRMGSGKHLNDFCSPTCTGDPGRHTAAVRSTNVSESVSGGSFAKSVQSTPSSELPPVEREIRVMRRVCKHPYVAQLKEVIDDEEEDSVHLVMSYAEKGPLTVMHAFDTVLGCAPCDVVRPFSRCVRLLYQLAEALIYVHRHRIVHNDVKPDNILLTEADNILLTDFGESVLISKNPPQLPGSHMFVGAAGGEGLNASVLVPHNRWKSSRGANDSWATMSIVDRLPWGPGVAGHNANTSQMMTETSFLPESSMFLAAGVDVEGRLKGNRLAIGTPAFAAPELIMSSTCSYDSDAWSYGVVLYSVIFGRLPFAAATISDTFDAILNSSLLFPALEAIPQRVGMTVTAYDQWVELCRKLLVREPQQRLALSAVLQHPLFRTASTLGTKSSTSTTGGTAVPRGQRPPSRLYSDLSSASTLRRSNRSSQVLRSVSGRDGSPLMSRAVRTTMPPEMSREAAAASASRRFSMEGSTSPPFAIGSVAQDAMSERHRPQTIASDSQTSSVFASSGTSTVSLSPPATTVVFGRRSKPILAGDVAPQTWREMRPVSAARPECQYASQSFSPAGQYSFYGASSVHTASFTVAEQRGRRREHTLVYNQCLSSQSSSVTESAINESLFSASTPFKESPPDRIVTPGMQLTSCADFTSPLPCPLTRAGSNTPDLGAGENERSQQHQIGKEGSSNPNGTGATTTLAVVAAPAPPTSPPATSSAGRPRSFAATRRTREGRAALTPYVERRCNGEESREVQGSCITDLDYFSCWDSSVSEAADSGGGEDEELRQTIHDRVSQRPKPPLQLSCRDSCGSLNSVEPLVSVQEVAAQHGKQKGRRECVHLVPGFPNGDSTIVLGSPGNCTAALGLLRKAREAESSAQRRDPKSSPPSEDLKLGGAGRGRTSPCQPLHKSTSELPPALTRRLQFWRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SE62</accession>
    <name>A0A088SE62_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">LETM1 and EF-hand domain-containing protein 1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_290960</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700704.1">
        <property type="nucleotide sequence ID" value="XM_010702402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SE62"/>
    <dbReference type="GeneID" id="22576860"/>
    <dbReference type="KEGG" id="lpan:LPMP_290960"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290013700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_290960"/>
    <dbReference type="eggNOG" id="KOG1043">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275278at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033122">
        <property type="entry name" value="LETM1-like_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044202">
        <property type="entry name" value="LETM1/MDM38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009">
        <property type="entry name" value="LEUCINE ZIPPER-EF-HAND CONTAINING TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009:SF1">
        <property type="entry name" value="MITOCHONDRIAL PROTON_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07766">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51758">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Letm1 RBD" evidence="10">
        <location>
            <begin position="129"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="472"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="479"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIO00047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="504" mass="57006" checksum="62C86187F19F5D8B" modified="2014-11-26" version="1">MLRSTLVRRVNAQVANSTAKASGAITQRVAQKPPSKVKYYMCVVYEGLRHVYHGFRLFFINTRLAWKYSRQLKKGVALTRRERLLLESSTKDLLRLVPFSFFIVVPFAELLLPVALKMFPGLIPSTFESESQGRNRLYGDAMKTLRARQRAMDYLSATALATFDKEQQEVIRRAVMGDSIAPKDIRLVAPYFDRNGPLSVFKVPDNIVVGLGRSVGVYKWYHTLLPTRVLSPIMRRSIIRRYHEAREDDRLIRLEGLDGMSNDELVKANQTRGMRWTEGTETLRVQLEWWNSLAQDGSVPYNTLWWIKPTRYSIRKSMNNLPVEQRRQLLGIQNLPETVRASLETLCETVDTMSSISDEPNSADKLVEKIEKITSSAEKSDSDIGFEGLQEAVGAYLTEENVKRMFEKLSKKKLPEESVVVSDVIECIGQETHNSSHVVSTVFDAFDYGAGSKPITEKVLLGIGARCRKAVRVPSTPKAAEEKPKSTSKGEEKKSVETAPPGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SEB0</accession>
    <name>A0A088SEB0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_291480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009398">
        <property type="protein sequence ID" value="AIO00097.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700754.1">
        <property type="nucleotide sequence ID" value="XM_010702452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SEB0"/>
    <dbReference type="GeneID" id="22576911"/>
    <dbReference type="KEGG" id="lpan:LPMP_291480"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_290019000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_291480"/>
    <dbReference type="eggNOG" id="ENOG502S4KV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="261794at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO00097.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="539" mass="59200" checksum="01CD6B6D28CCE85A" modified="2026-01-28" version="2">MATPVRFTKVSASAPRWSWVAADVAENLVRLQGVLHRATPRQSPLQLLHGQARQTATVTKLSGVSRCLSTAAPRTGIFSVAGSRGSSPSPKQDSPAPSRKSVHSMSLTLSAESVWETVPHWCELCSEPVNSWHSHMGKRDHMCLEMILNTMVSSKGLWEPDKVWDSIELFRGHYTKRPRGQPRTPSPTVQRLLKEGLYVPSPDHPLSIFYDAFDRGDPYARREELHLLLLYLNECGMLCLTPDLFPPAVFQGHLLLHSEVVPVLTRIFPDGEVRGISALLQMITCTYGLAAAYEMCGMERLVPVSLLQHRGVNPELMSALSSVEEFDSFAASDDATGGIGGEEALGENAEGDTIDSPLSTDQSMAMRSLSAAMPRAILGSLRWALAPEDASPPPAIFQDHKRNAYLTTLAARAARLLMSELIFERISEYVHRLEWFLRTDIGREWLHSHHDGHREADAGSSHAASPRWLRTQCITPSLSNEGNVAYTNGGLVAHGLNGTAASECTVQMHDAARKARMHGRRGLPRAPANSPLARSVRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SF43</accession>
    <name>A0A088SF43_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleoside triphosphate hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">YCF45</name>
        <name evidence="5" type="ORF">LPMP_302040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701227.1">
        <property type="nucleotide sequence ID" value="XM_010702925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SF43"/>
    <dbReference type="GeneID" id="22577257"/>
    <dbReference type="KEGG" id="lpan:LPMP_302040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300024600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_302040"/>
    <dbReference type="eggNOG" id="ENOG502QQ4X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26838at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002600">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045735">
        <property type="entry name" value="Spore_III_AA_AAA+_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20953">
        <property type="entry name" value="KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20953:SF3">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19568">
        <property type="entry name" value="Spore_III_AA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="231"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="457"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="508"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="526"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIO00427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="551" mass="60612" checksum="D7BF84C1901FA532" modified="2014-11-26" version="1">MLPSPSLLVVGRNLRTRVGANTNERLLAAERDEPATTSARPPPSGMDLSYITAKMPDLLPTYQTESAVWSARTFRSAWSTLHKAYASFLKTDPARAAELRAKDWKGLALYNSYAETLHLMSFLFPALRTAITQHPSFDYTQVEELFVHLGQDVEVRGSGGWVIQLPPPTTAELQYLMKHIGRFGADGRGCVANTAHRASVWRGRHGEALGVTLRVGRYVPGAARALLPLARRGSLLILSKAGMGKTTLLRDLAAGLAQDPLTPRVTVVDTSNEIGGDGPIPLPYLGRCRRIQVPRREDQSRVMIEVIQNHTPDYLIVDEIATEEEAEAAWSISQRGVHMIGTCHGEHLEGLLQNRALNLLVGGAAQAFLSNEERRLRNKTKKTVLERPYNSPFSFVVELHARNRAHLYVDVNKAVDLALDEQSAKLNAAIGAAVELSELLPSRVERLLLLQDEKTRKLKGASGSTEHDADLGEDKDDATALSSASQHTMDEEGYTFLADNDSGPQGNCSAVHSTFAAPNHASGRCTQRRAGKQRRPRKTDADLWRELKGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SH12</accession>
    <name>A0A088SH12_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Calpain-like cysteine peptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_322130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009401">
        <property type="protein sequence ID" value="AIO01097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701897.1">
        <property type="nucleotide sequence ID" value="XM_010703595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SH12"/>
    <dbReference type="GeneID" id="22577954"/>
    <dbReference type="KEGG" id="lpan:LPMP_322130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_320026900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_322130"/>
    <dbReference type="eggNOG" id="ENOG502R4MA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="444540at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055325">
        <property type="entry name" value="CF161"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24274">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24274:SF2">
        <property type="entry name" value="CYSTEINE PEPTIDASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO01097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="32806" checksum="5846DDE470333E59" modified="2014-11-26" version="1">MPHRALLGNWFEEEAYERDRRRLMQGRCGGMVEASAEVAHTMAKIRHHNTPHVIAPIAPDGYLRFYAPLMLQNAHTCGFLSVDLDDRKATTTGWQVECSTALAEEATSRCTVVLVPAAMPQTDSFPIPEDEAEIVHYGQPFYLMTVRELCEDPLFLMSEFITPGCASRVTQRLQHTYFSPDGGSAAAMWCVEDANPAYQEDMRDRPVKANDVIRIRHNMTAAPLASLKEVFYNDFGAQYEVGCGRLTVLATKRRGGPPAAENLWMFIHDGQGHPKESGEDTLRGAAYMPKSSAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SI00</accession>
    <name>A0A088SI00_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="7 10">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LPMP_331650</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="12">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 10">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="7 10"/>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="AIO01457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010702257.1">
        <property type="nucleotide sequence ID" value="XM_010703955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SI00"/>
    <dbReference type="GeneID" id="22578318"/>
    <dbReference type="KEGG" id="lpan:LPMP_331650"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_330023200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_331650"/>
    <dbReference type="eggNOG" id="KOG3111">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1927044at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000171">
        <property type="entry name" value="Ribulose-phosphate 3-epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004076">
        <property type="entry name" value="PRK05581.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="RIBULOSE-5-PHOSPHATE-3-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="12" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9 10 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="175"/>
            <end position="178"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="226"/>
            <end position="227"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIO01457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="256" mass="27299" checksum="5EBF391A0F85D3B5" modified="2014-11-26" version="1">MMPEFNRYNHEDKTTWLNAVEKPKAALEAIIDPSILAADFCQLGDEVASVISPAGGAVEWIHVDVMDGHMVPNISIGPGVVSSLRARFPNVFFDVHCMVSDPKQWVPVIAKAGGSGYTFHIEATDDSKGLAKLIRAHGMQVGVAVKPATNLTQELKELIEGCYVDQVLVMTVEPGFGGQSFMAERLCFIAELRHNYPHLNIGVDGGIGPGTAEQAADAGANILIAGTSVFKASDRKAAIEELRASAKSGISKNSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SL70</accession>
    <name>A0A088SL70_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_354190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703352.1">
        <property type="nucleotide sequence ID" value="XM_010705050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SL70"/>
    <dbReference type="GeneID" id="22579447"/>
    <dbReference type="KEGG" id="lpan:LPMP_354190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350050000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_354190"/>
    <dbReference type="eggNOG" id="ENOG502T6UB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="190375at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIO02552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="529" mass="57164" checksum="E15334CBFA10003A" modified="2014-11-26" version="1">MGPDTAFIYQYLNSRGQSGLELDVLCRHYSRITPAYGCRLVNAVLSALEDASAHAPVEIDATVKIQATFRMYQQRNAFLTLRSSACLIQRVYRSYATRKHLDVERAAVRQMAYLQAVFDMFATRIQACYRGYQSRKTKSNYYAQQAYLKVVTARSSEVLAQALSTQVEQDTLRKAEAKRQDELSYARRTAQMHYMVSTCSVPSIYQRSVEPPPGKQSVHNTLHTSRGVCGHSGESGLVSPELPTVKLAKERSDSNAAEDETLMAQVAAYVSGQKLESDIRHHARAARLKRIAVTAKRSPSPVAPTVLTVASLQSSDRTTAVRPRAEGTTVRTTLLVQGARLPELAASQPVQRSHQVKATALAASPTVPWEELSLTHPPQKPLTTPGLPLKSSFFSQSGSPATLSRTTQASRKPRGGQQTAEGDSFHATGTAAAAAAAPAPSEASIEASILGAAVSSFHRRFAVKRHDCLGCQLSITNGIVSGGAGSHALSGPLSPAREEAAVQRSVDQKVMQALHGDAVFKVSARRGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088SLP7</accession>
    <name>A0A088SLP7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ras-like small GTPase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_356030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="AIO02732.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703532.1">
        <property type="nucleotide sequence ID" value="XM_010705230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088SLP7"/>
    <dbReference type="GeneID" id="22579631"/>
    <dbReference type="KEGG" id="lpan:LPMP_356030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_350068700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_356030"/>
    <dbReference type="eggNOG" id="KOG3887">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26136at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11385">
        <property type="entry name" value="RagC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001086">
        <property type="entry name" value="GTP-binding protein GTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039400">
        <property type="entry name" value="RagC/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF2">
        <property type="entry name" value="GH16429P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIO02732.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="365" mass="40774" checksum="7B063DFFBD659BB9" modified="2026-01-28" version="2">MSNDMLALPKVLLMGLRKSGKRSIQKVVFEGMQPHDSATLATTVQPEKSTVHSNDFVNFEVWDFPGQNDPFDPSNASRYDVNQLLENCGAIVYVLDCRELIDDARARLLDTINAAYRYNPELCIEVFIHKVDALSEDHQADLLASLQRRVEEEAKQLLENVQPLRLNFNLTSIYDHSVFQAFSLVVQKLIKCKMPYITELLQMLNSNSNIDLSYLFLSHSKIYVAVDERNRLKSRTYDLCSDAIEVVVKMSRIYTRAGDSAAAGAKDASADSGHTLAASPANDATTVLTYGSADGYASDVSDLYRGANAVIQLSSEDCIYVRELPSSLTLVLMMKQTHLENRALIDRNVDIFYKAAFDIFNTSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4N3</accession>
    <name>A0AC62A4N3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3520100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009404">
        <property type="protein sequence ID" value="XUY36842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="349" mass="38002" checksum="FFE8A10BD9C6F832" modified="2026-01-28" version="1">MNPHCRPVTPFLSISSPFSASVQSGTFLLASLQHLMSSSQRGHASSSLHVVTHELPPLGEVGAASPLQAGAALAQGTLAPAILREVSVLPSLVEEGDTSEEVHLIDAPATTAANSISTAQVASPHNTRAPTLPSTPVAHRASTRPVEMYALEEQQERSALENNQASCFETILAREVSDYLRISYHQRMAARQPTEYIGGNAPQNLEKEARRLHDSIRARMKAAEAEHQKFMSIYRPVEQVQLSTADERTPWSQPMLSLENQAEVKLATRRISCGTPHLSSSTSSLDGLFSVNAPPRQLSLDTRRMAPSEAQKGNNPGVRSEIQRQLRLGRPVVHKAGEWTADPLFTELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A4U1</accession>
    <name>A0AC62A4U1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Beta tubulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3320190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="XUY36727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="378" mass="42580" checksum="E436946AC20ECA6B" modified="2026-01-28" version="1">MDLEPGTMDSVRAGPYGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELIDSVLDVCRKEAESCDCLQGFQLSHSLGGGTGSGMGTLLISKLREEYPDRIMMTFSVIPSPRVSDTVVEPYNTTLSVHQLVENSDESMCIDNEALYDICFRTLKLTTPTFGDLNHLVAAVMSGVTCCLRFPGQLNSDLRKLAVNLVPFPRLHFFMMGFAPLTSRGSQQYRGLSVAELTQQMFDAKNMMQAADPRHGRYLTASALFRGRMSTKEVDEQMLNVQNKNSSYFIEWIPNNIKSSICDIPPKGLKMSVTFIGNNTCIQEMFRRVGEQFTGMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATVEEEGEYDEEEEAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A552</accession>
    <name>A0AC62A552_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3420440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009403">
        <property type="protein sequence ID" value="XUY36808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="426" mass="49418" checksum="9559EAD7F19D9C72" modified="2026-01-28" version="1">MMHFSGVVRRQMRPYYNLPSKSEHGRRMTGFLTPYRHWMWKQNELWRNVHEAQFEHLRKVYKRQWLESFRVNADEYIYKYNITKSAQLAQWEHEMQAQERKRRESQQLAQGRQALKKKHLDLLREFHERQFFYWYERASERLQYMARINYISQASIQEHIERELDKYTVGSKAPYPLNFAGQMPMLEDRDGNIAQVPANLMTNHATENPDGGATIYEPPEGTAVAEEKLLQMMASAQEEELRIRPEDGDAWSESMTDMDRSESARFDSRKVARSMEETDEEREVSRRAYIDRGKTGSKAIFRRPRFDGDGATSPSAGGTTPMKRRKSKTDRMHALQEQQDAAVAKATAKALKDEGSTAGATKRGEVAENRGRLRDRMITPSLETLQQSPEMMAQNKPGGRVRTHHLMEKVYGIGKFKKGGGGDEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A570</accession>
    <name>A0AC62A570_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">D-xylulose reductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_3320130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009402">
        <property type="protein sequence ID" value="XUY36721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY36721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="355" mass="38321" checksum="1BC73183B089A0F9" modified="2026-01-28" version="1">MALMQSLVLERKSELAIREVDVCDELGPHDCRVKIHSVGICGSDVHYYEHGRIGPFVVEKPMILGHEASGTVVAVGTDVKELKAGDRVALEPGIPRWDSAQTLSGLYNLDPELTFFATPPVHGCMSTTIIHPAALCFKLPDNVSYEEGALCEPIAVGMHSVTKAGVKPGDVGLVIGCGTIGIMTALSALTGGCSEVIVCGSHDARLEITHRYPGLRAVNTSRADELKRVVAEATEGKGCDVIFECGGAASAFPLIYEHAAPGATCVLVGMPIEPVPFDVVMAQAKEITFQTVFRYRNVYPRIIRLLSSGKMDVKPLISATFAFKDSVKAYERAMNRDPKDMKIMIRVYGDKTNML</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5M7</accession>
    <name>A0AC62A5M7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Elongation factor 1-alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1720080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009386">
        <property type="protein sequence ID" value="XUY37098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="449" mass="49058" checksum="C7CA18E3C4A6A3F4" modified="2026-01-28" version="1">MGKDKVHMNLVVVGHVDAGKSTATGHLIYKCGGIDKRTIEKFEKEAAEMGKASFKYAWVLDKLKAERERGITIDIALWKFESPKSVFTIIDAPGHRDFIKNMITGTSQADAAILMIDSTQGGFEAGISKDGQTREHALLAFTLGVKQMVVCCNKMDDKTVQYSQSRYEEISKEVGAYLKRVGYNPEKVRFIPISGWQGDNMIDKSESMAWYKGPTLLDALDMLEAPVRPVDKPLRLPLQDVYKIGGIGTVPVGRVETGIMKPGDVVTFAPANVTTEVKSIEMHHEQLAEAVPGDNVGFNVKNVSVKDIRRGNVCGNSKNDPPKEAADFTAQVIVLNHPGQISNGYAPVLDCHTSHIACRFADIESKIDRRSGKELEKNPKAIKSGDAAIVKMVPQKPMCVEVFNDYPPLGRFAVRDMRQTVAVGIIKAVSKKDGSAGKVTKAAAKAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5N3</accession>
    <name>A0AC62A5N3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histone H3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1620580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="XUY37069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="66" mass="7238" checksum="D87F239EB5F19D1A" modified="2026-01-28" version="1">MPCARCRACRRRGGPALPEQRDPGDPGGVRCVADGCHEPGQHPREACVTVRPKDVQLAVRLRGERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5P3</accession>
    <name>A0AC62A5P3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleolar RNA-associated protein (Nrap)-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1820070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="XUY37118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1268" mass="138296" checksum="4D6DDB08AEED8CC1" modified="2026-01-28" version="1">MALQRYQLSWSDQLMTRVEAHLRDIHSVLHEYYESCGYPTEVETRHVAIIQRAVTGTREESEFATVTAAAPALQLDVVSPVGSFLLRTCVHDTPFPELHAQRGVGADLVLSIPVNRCTAADLKGGLYLERRQSFLHEIQGYLEQLVSGAAKQKSDSSAAAAAVDVAASDTDSDRDSEEGRGASSRSRQHGKVTQGAEKEELNVAAAARLSRVEVRVVPIHGCYALADKQILQLRFRRRRAAAAAAVDAYETFFVNLHFRPSAFPGHAVDMAVVRRHPYYSYCILEDYLMPHYLKKLHEVCIASASVRRAIVVLKCWAHHTGLMSAASGHPEALNGFVVAAIVLRLLEEGIVTAGMSLDNIVRAVWVQLSRGFFLGTPETVGSSAARPVKVPAAEEQGEVSVLRLAGEPHNILFRTSAAFFRHVVGPAAEEALQHPFAVEVVDRIAFQPLPLRYDVALTVQLSQTTTSPVETMDRSPAAIKKSSLWRAPRVEAIQDTLRVLKEALGVRCNYITVWRTDADRLRVVVQLTSEAEGRNRLTRGPPIEDTSAVERFNTFWGTGLTSTRQFSDGAIYRCVLWTFPEDQGTHTTVALSASTVLCRIVEFALRAHVAPEAAVAVLLGGLDGYLAERVGGEWRDAAPLMQRSLLEATKAVQYMLQNLPRGSVPCRIVSLDVIAASERHTEVFPVRPHLALTYTTDDLADASFAGLSTAPTIEPIHCVLNIDDNHKIPDTMEAIAMMKGAIAAQLAKTLQAHYGGKSSSSDVVRSPIRTQCTSQSVDIIYRGYLFRVYVAHYREVSLLRALQRDTEANLLEMKLHWTAQHAKFMRTIAFGHHSYSHAVRLAKRWIGAMYLYEFVQPEAVELLVAHAYLQPAPHTPKTPAGGFLRFLQLLATHDWSTPLVLPFTDDDNDKTAVAAAALVRKLGDQQGMFIATPYAPAASPFTVLTPRLMIMGRLVQLAQSVVAVLLRHLEGHNATAGEVEAFTSSPCAFDFAMKFHPRLVLQPDRALSIGAAAASVASALHEAAPPSGIVLASSEADTLAAEEAAAAANAVIRLWQLDELDADTNGREYINQLVEREPAAHAVRIARAALRERGMMFYDALAPSSLYVVGISAERQVAKSRQLHDAILQVGRGALLPAPPSAFTPVVEVSHSSDAAGHAGFESKDDHRPHVPAHHQGRAAPRLRGAVLHKQSEKAATGALQLPQHHHKRSRSTKDHRGPAAAVAEAAHAKKTKRETAVEASPSTEASPAPAVAKKRSQKMAKATKVHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A5S9</accession>
    <name>A0AC62A5S9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tuzin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2020080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="515" mass="56335" checksum="71AD91DFB464EE16" modified="2026-01-28" version="1">MLGPATRCCLLTAVRRSAFAQPGLEGLRIAAYAPAEPGVPPSPRRLPVAVGRVVAQLSPLVFAVDFRDSPPPPAVSLGSRVYVAYEREGAAPLPQQGGGVVDDAPGRGFLMGGFVVRVNPNGTLGVLLENNRVDLGVPPERIAVTEGVCKFVRHPGYLQVAEWVRSAGLSGADEVEGTACMLYHRGWRAERLHLLEASGTHCMAHLSQRSRMSLMEKAEWQRDHHRQMRSLSWERVKERDRRYMAAKYAGILSASVAFCGAFSLFGWNYRNHLTHQRTSQMRFAVRTLCKEAPPGASTTADAAHQLSRQTRREALERWIRPVFQQLDTAHPRIVVITGPFGCGKSSLCRAAMREEGMAGVVVDVRVREDPLRRVVMTLGVPHVEACGDALDFISEACCRAKSMMCGKTPVSVLRLREADSLARVYNEALAPACERRMCHVVMEVLPGALSTAGTGLPRLGLCVVPALCCVEAVQGTGWRATVRRSPALEDNVLCNPVADAWMFPSKLFHSASRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A604</accession>
    <name>A0AC62A604_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histone H2B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_1920020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="XUY37123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="111" mass="12387" checksum="CDAAE454AFCD6C72" modified="2026-01-28" version="1">MAVSRHAPRKASRVHKAHRKPKRSWNVYVSRSLKAINSHMSMSHRAMMIMNSYVTDLLERVASEAASIVRVNKKRTLGAREVQTAVRLVLPAELAKHAMAEGTKAVSNASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A681</accession>
    <name>A0AC62A681_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amastin-like surface protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_2021060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="XUY37252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="195" mass="21821" checksum="4422187F17640540" modified="2026-01-28" version="1">MEFNPFIIVYAAIQFIAFLLVLVGTPLDIFRSRQRSIFNETSCVLLWGVKRNCSSIAYAATSDDRWVMCPTRRTHFRVARVFAVITIGVYCAAFVLGFIMLCCYACLRWVCLGLNIVGFVTLATLCALMVVSYETDAYPLCPKLKNDFTLSSGFFLFAAALCLDLVSIAFLFIPWSHENVEGSSSHSKEGNSQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6A7</accession>
    <name>A0AC62A6A7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0920210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="XUY37338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="345" mass="38452" checksum="1CAA48566EA3C950" modified="2026-01-28" version="1">MPTKPINAVCTMATRECVAELALFHRALRTFHPTLPLHLGCSSEVRDAAEAATDATAPLRALRDDAHVRWVPCLDQYGPVISRTEMERQRGVWYPARHTDFMMEKANLMELAMMTTKASTPTVAFLDCDITLLRELPCVPAAAAVALSPHWIREADEAVFGAFNGGYVVASTPEVLWEWRRATQTSRYFDQASLEHVAAIFERRALLHQLPPQHNYGFWRLLQPRCGSVVDEAKRFSIAPAPPSGSGQQPAATVVHYDGAPLCSVHAHFFAPNPPRDVRLFCAVLRRWLGRCRPACAAALAPPGGRWAAPAPRAPARDPPRSAQNNRKERREASTHRRRSDKPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0AC62A6K4</accession>
    <name>A0AC62A6K4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_0420020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="XUY37419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="XUY37419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="522" mass="52693" checksum="0F3DC9132BDCD79B" modified="2026-01-28" version="1">MAPLAPRCCAPALLCAVLVLAAVLVRAESVTVTDDLTMSGASFNDYTMTLGLASSTADVVTVQLMNSQVSGKGLTVQSSGDGLASSARLSMSMLLTTVTQAAITFSGAMPANSDIRIVSTIGSLTSAQSLFDFSGLALDSNVTVTVENTAVTWPKDSINTGSIVLISAGSNAIGIRNLAALFVLDAVATNGASVVRVDAQSSFPVSKAAVLAIDYGRCEECTGALVSINAPLVVDGSSMFRVTNCKAVGASKGLLASAGSTTVSGKSVYLVSDSAVESVSLFSFLTGIEDSSEPYPFTVSGGSTVSFLNLEAPSTGITNQDTLSASADSKVIGGGCVIKGVALNTAEVYKSNGLAVTTVVDRQGASGGTCANAKCIPGNTGAGAAVSGTDPCTCQCSSMDYNPPSCSTIVDPTQNYNPTDVCVVPNCITCDRLSPSTRCTQCATGYILTSDQRCILPTTRPPVCNVPYCTQCVTGSGSRCSTCHYGYTSINGACIANANAAAGAHTVALAAVVCVAAALYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RGW8</accession>
    <name>A0A088RGW8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycan beta 1,3 galactosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_020120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009371">
        <property type="protein sequence ID" value="AIN95192.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698157.1">
        <property type="nucleotide sequence ID" value="XM_010699855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RGW8"/>
    <dbReference type="GeneID" id="22571822"/>
    <dbReference type="KEGG" id="lpan:LPMP_020120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_020120"/>
    <dbReference type="OrthoDB" id="252344at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN95192.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="810" mass="89725" checksum="F5DCEF67378E39A0" modified="2026-01-28" version="2">MWMSSEMGTPGGSPTSAMPFSGPPLSCVTSLPRRCTGFFRYSATPNCTAPRSPKLKRGDAGGSRPPPQLWRLVERVRLGAARLWGRLLGMRERPMHLLMCVALCVILVVVIWWLSMWCRRRHPLSEEQLARLLGPLSKPWSVLVQHEGAVDRLSKVILVEEWLARCSSRGTPLTECNEPLLLSPHMLPAWTLHVVEEDCADCTDQQTYASAVEGVVLQARHAVFATSAAPLGRVGPMLLAMASVTDDVDVRAELPQWEWLRHVHGSGFPAVGGAAGVSAPPRAPYLAVMGIPSTDQRPRAALREAQRKTWLAYQEVARRDNHFTGALLALYVFAAAEPDPILDPSEDSAESLHSGTSAASPGRAGLRVLLPTTAEYKTATQALLARAMQADGVDGVADEGFAQRRMELRRGWSTAAVDGSPCAEVASSWTAGGAKTSALSYLSGALSLPVTPAFTSPAEYICHASSALWQEALTHRNVLWIDMMTDRRPTTKKKLGETDDWGLPVEVGMSQKLILWLAYAYHAFKDVPFIIKGDDDSYMKVPQFLSDVRYVMSGMQARPPPPPADAANRSTYALDMGRAECMYWGSLRLFGQLTYNSGLLFMLDRLLARVVLEPHPNGEPTTAVLLAVTDFDPSLSRAYYTFVYHHEDVLLGLLIRNALRRARDICPNNRVWFIKEGLARFHDVHRGTPHDVTWSTVVAHRCTPANNYYLHHFFQREHYATLASSGGKRRAERAAVVQAAEWVAEHRRAMGPEVVGWDAMPAVQWVRNVKRTPAYDMAEADGVPVYRIEYKYWAHQFTAVDDGLYSLPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RGW9</accession>
    <name>A0A088RGW9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_010170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009370">
        <property type="protein sequence ID" value="AIN95118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696660.1">
        <property type="nucleotide sequence ID" value="XM_010698358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RGW9"/>
    <dbReference type="GeneID" id="22571746"/>
    <dbReference type="KEGG" id="lpan:LPMP_010170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_010006100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_010170"/>
    <dbReference type="eggNOG" id="ENOG502SJHX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265489at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="466" mass="50511" checksum="87C28B0FAADD5DE6" modified="2014-11-26" version="1">MGNCCGSVSDNGIASTSPRPSPPRRRRWPGLTRSATGSEKTMRKQRNGLKFTPLAVTNMPFLMSRGKASSKPIHGTAVVTALPTASLMDGDAATLATPIHKQGVHVTTTTPHGASASGFDLLMPDLFSVSASSFSALLESFDMGDHSEGSINTCRDGEGQSSLVEVSQPTQSLRGNTHMHSDMDMTSELELLSFDRTGRRSERWGCSELDHSRLHQLIIREAEVRASLTVVYMNLHQQLLLRLTRERLIAVHLGMLQRYQSEWTVQCMCWIMALESVVREGVARERWAERAVLVRRVGSSRVSPSPSSLTRDDAMPGTADSHVVKRQDSLPHVLNLYTTADLTPSEGAAEDDTWSMRSQSMRAFSSPAPSALHQQQQQQLSALSGSRSASAELTAGLHSVPRVSARHASSSVSSSASGLRSPLLTRSVTAAQQAQRYRIVRGPQLPVDEGHPRALGACVCVPEADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHC2</accession>
    <name>A0A088RHC2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">diphosphoinositol-polyphosphate diphosphatase</fullName>
            <ecNumber evidence="2">3.6.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_040520</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:79699"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:79700"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>3,5-bis(diphospho)-1D-myo-inositol 1,2,4,6-tetrakisphosphate + H2O = 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:56312"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:140372"/>
            <dbReference type="ChEBI" id="CHEBI:140374"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:56313"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + H2O = 1D-myo-inositol hexakisphosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:22385"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>6-diphospho-1D-myo-inositol pentakisphosphate + H2O = 1D-myo-inositol hexakisphosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:79703"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:230534"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:79704"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein-tyrosine phosphatase family. Atypical dual-specificity phosphatase Siw14-like subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.52" evidence="2"/>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="AIN95377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703699.1">
        <property type="nucleotide sequence ID" value="XM_010705397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHC2"/>
    <dbReference type="GeneID" id="22572011"/>
    <dbReference type="KEGG" id="lpan:LPMP_040520"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040011500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_040520"/>
    <dbReference type="eggNOG" id="KOG1572">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052848">
        <property type="term" value="F:inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052845">
        <property type="term" value="F:inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14528">
        <property type="entry name" value="PFA-DSP_Siw14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000035">
        <property type="entry name" value="Tyrosine phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020428">
        <property type="entry name" value="PFA-DSPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004861">
        <property type="entry name" value="Siw14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF48">
        <property type="entry name" value="INOSITOL PHOSPHATASE SIW14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03162">
        <property type="entry name" value="Y_phosphatase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01911">
        <property type="entry name" value="PFDSPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="11">
        <location>
            <begin position="16"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="227"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN95377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="287" mass="30900" checksum="01DDD2FDACD45D1A" modified="2014-11-26" version="1">MPTTPPSREPLVPTINFSMVCPGVYRSGYPTKKNFSFLSALRLRSILYLCPEDYAESNLKFCEENGVHVLRFPTEGNKEPFCDISEPLMHRILSAICDTRNLPLLIHCNKGKHRTGTVVACLRHLQGWSLVSIFEEYKRFASDKARVGDQQYVELYHPIVRLTPPFVASWVIVTPRATLVTSDRELMEAEALQLGYSPLAPDKYLKKNGSGAAKPTTNPVAAATAESGLTTTTPTSSPLAPGPKQQPSQPAASAVPMSAGNGGHSFVPSIAVTAAAAAAATGFGEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RHW8</accession>
    <name>A0A088RHW8_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ADP-ribosylation factor-like protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_040440</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in apoptosis. May act as a tumor suppressor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009373">
        <property type="protein sequence ID" value="AIN95370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703692.1">
        <property type="nucleotide sequence ID" value="XM_010705390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RHW8"/>
    <dbReference type="GeneID" id="22572003"/>
    <dbReference type="KEGG" id="lpan:LPMP_040440"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_040010700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_040440"/>
    <dbReference type="eggNOG" id="KOG0070">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00878">
        <property type="entry name" value="Arf_Arl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000898">
        <property type="entry name" value="ADP-ribosylation factor-like protein 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0519">Myristate</keyword>
    <keyword evidence="2 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN95370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="190" mass="21084" checksum="2317BFE5FFB71A83" modified="2014-11-26" version="1">MGNIISGWFEGLFKNKKASIVMVGLDAAGKTTILEKLKLGTSRETVPTIGFHVESVDYRNVTFHLWDVGGQKRLRALWKMYYEGANAVIFVVDSNDRARVGEVRDELRTLLSDPLLSGAALLVLCNKQDLPQRLTPAELVDGLGFRDLSDKGLGRYLAGHKWYVQGCCAHTGDGLYEGLDWMCSHLPDNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RI04</accession>
    <name>A0A088RI04_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prolyl endopeptidase-like</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Prolylendopeptidase-like</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_060320</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Serine peptidase whose precise substrate specificity remains unclear. Does not cleave peptides after a arginine or lysine residue. Regulates trans-Golgi network morphology and sorting by regulating the membrane binding of the AP-1 complex. May play a role in the regulation of synaptic vesicle exocytosis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009375">
        <property type="protein sequence ID" value="AIN95592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010703914.1">
        <property type="nucleotide sequence ID" value="XM_010705612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RI04"/>
    <dbReference type="MEROPS" id="S09.034"/>
    <dbReference type="GeneID" id="22572238"/>
    <dbReference type="KEGG" id="lpan:LPMP_060320"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_060008800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_060320"/>
    <dbReference type="eggNOG" id="KOG2237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="248387at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.120">
        <property type="entry name" value="Prolyl oligopeptidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051543">
        <property type="entry name" value="Serine_Peptidase_S9A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11757:SF20">
        <property type="entry name" value="B PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11757">
        <property type="entry name" value="PROTEASE FAMILY S9A OLIGOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50993">
        <property type="entry name" value="Peptidase/esterase 'gauge' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S9A N-terminal" evidence="10">
        <location>
            <begin position="51"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="9">
        <location>
            <begin position="569"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="872"/>
            <end position="905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIN95592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="905" mass="103824" checksum="F2C2A515B9793943" modified="2014-11-26" version="1">MAALFPWVPASNLGYSLSRKAVNKWCPQLRNSYPLPMLDGPLPTEKPEGLELHGEAQKPDPFRYMEDLFDRNTQEYAKKEMQHFSLISSKFDFRHSKGRLWAELDAKVVVSSREGGYDKGEERIGDYVYFTRVVPGHDSNATGFYRKRFGEVDLLAEELINPLLLQQHFGYKDCSIGVCRVSDDGRYLAYTLSVEGGDRYLCHIRSIDNASLFHVIRGTNIVSIEFGSGSQFFYTESNELNRPHRVMMQEIRPGILEPPVEIYRDEDEQFFVDVRKTKDNRFVTITSDSKVNGNALVVPASFPIIPTPLKSFFKEGKPVEIAGKSGWNWLEHYNGNFLMVTSDKGPNYRVVYIRDEVALAYGKEAEWKELVPHRDDVQISDVDLFQGRIILYESHFAFERIQHIRVIRCDGGLDAAAQTPRIEDVVLHFPQLTTVTPGLNKNFGQEAMSFVYSSLIQPPRDCVFNFSSDITSTQARLCTSEALFTQRQSEHFTPWDYMWPYSIYRDVCVSEDGTEIPITICQRRDAFIQEATDFEAQPNTPKHCLIYVYGSYGEVPSMHFQLAPYIWMLRRRWTVAFAHVRGGGELPNWAQLGKGENKIKCIKDFIACCEHMVDMGYTKPELMVAAGASAGCVPIAAAMNMRGCGLFGNALMRSPFLDIINTMIDPDLPLSLAEREDWGDPLNNKRDLDLLKQYDPYYNVNDRVTYPGMMISVCLDDDRVPAWNALKYVAKLRQQRTRRDVDPVARPLVLRMRPSGGHYLWGDTENICEELAFLCSQLDLEGPGKVLNDMDIMTHMHNLTTTGAMDHDDQQKVFLKWDNWERERIDYHVKLNSFNWEPNFRKVKAQKEPFFWVPTDSDLDQKKVDEMFRAKERDARESVRSGAKVGSLGKATGRNLYQEEQRGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RII7</accession>
    <name>A0A088RII7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vesicular transport-associated repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_071020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009376">
        <property type="protein sequence ID" value="AIN95787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704109.1">
        <property type="nucleotide sequence ID" value="XM_010705807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RII7"/>
    <dbReference type="GeneID" id="22572437"/>
    <dbReference type="KEGG" id="lpan:LPMP_071020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_070015500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_071020"/>
    <dbReference type="eggNOG" id="ENOG502RQPU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267410at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="660"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="864"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1118"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="259"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="363"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="660"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1126"/>
            <end position="1139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN95787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1139" mass="127080" checksum="3E2CBA4D985873F6" modified="2014-11-26" version="1">MTDFTALRANCTALFDTAMPPLLRGSIPSAPSVGVFSTSQLDRCSMYAGLRADSAVGMSVAPSATLVSSRSMEATLLRREWELRSEYYRLYAEDQWHIRQQREEQRRQDDKAERQRMIEAARAIEEERARRVAEQQEHLLQKERELEEWKLERLKEANSARRQQQQEDERRRELQHERELARVKEEAASGRKAEEVKVAVEQSLQRMQSTMQEQLREEVRALEAAHRSELTRREEEWAARVKAMEISRSTELAELTHQLQLDQTRATRSEEQLREARDQLTKLLQEVDQLRVQLQSGGPRFERDREAAQRLAETHRSAIERLQLMYDDDKRALQRRYMEDRERAKYEQDRRAEELKESHAAVLRGKDSEIDQLSDRVRQLERELQDESTKLALLRTSGEQTIPMSVENARLKDEVRQLLTAKAELEETTKRLERNLREADGRVENQNKQLRTLQADTVSGQRQLTEARDELRRDNADLKSQIAMVRNSYEEEVMRLQKQLKSTEEVATQHDMQDMGQSAREAVERAEEARRSTENSLAEVMRKLKFAEEEVQSSRRNAEAAQYDVAQAQGRIQELQAKVEERAAQVRALETELQGKVNLGYEVREAKERAERLQAEYDAERESRRRQHEAALEAKDRELQQCRADMLTVKQRFHALRAESDTSKLDREGHQQRLTRQLTEREEEVAQLRRQLEDSRQSLQQWKATYEELQRSRGTSTDDYEKVVRERDEELQECHRRLRQMQGEKAGLEDRMRAEEAARISVTAQSNDVQRSLREREAQIEQLEREVRELRAQPALLSALAVPVASPLPPSGSLPPSLPHAPKAPLLSSMTLASAPPITADITPTSCAAPPSVMLPASTPKAPLVPPLHSTGGPTAAPPAPVSAWDSLPPPPRPSSIPTAEKPHVMAVPLTHSLDHGTASTDGTTEGTPLSIPVPVSLSLSPFQVGRQSGDGPSLTIAVPTPAGALSHTASAAEYAISPAPITVAPRSPHSGATAVQAVHVPSTPAPPPLLGAQVTPTGSTSSFALPSSTAPPPVLSVAGGVLSGVAGGPTPVPVPVLSPHATIPVPKVGVPSVPVPGPSCASPSPSAGGYGASPPPPPIPVLVAVPSFTSTSVLAASGNVDKSSRHDHRSHRHHHHRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RIZ0</accession>
    <name>A0A088RIZ0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_070690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009376">
        <property type="protein sequence ID" value="AIN95755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704077.1">
        <property type="nucleotide sequence ID" value="XM_010705775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RIZ0"/>
    <dbReference type="GeneID" id="22572404"/>
    <dbReference type="KEGG" id="lpan:LPMP_070690"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_070012100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_070690"/>
    <dbReference type="eggNOG" id="ENOG502S377">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10265695at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000125">
        <property type="entry name" value="Hypothetical_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN95755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="335" mass="38067" checksum="58E817DAE3B7ACAD" modified="2014-11-26" version="1">MYAGFPRLNVTEAQEAVDLDFELANEKGCVKATELLVPKVVNLSFPAVCALLYNARTATSSRNIFGSVIGLQLQDVVEVTDVKINPSIDIEEDDRMTEEERMERVRKERKLLDVDKAIFENMYNQENLDTNVIGQFVISSARFNPFSTRTMRKLQELHRESLPAILLTYDPFRTGLLGRPHIRAYTPTAAYYKYDSLVSTERGYQRRRSLAQYAKESGVTKEGVLHEIPVKLEVDAFHRLNLMNLQPTSIGDSFKAIQSMAVSNYMEALLSSIRNNTDQLKQKLDYEGNIKDNGNVPVGQDAETMLLMKHVRDQTDHLDALCDSTLLYSSMLRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJ06</accession>
    <name>A0A088RJ06_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_090510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN95967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704289.1">
        <property type="nucleotide sequence ID" value="XM_010705987.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22572621"/>
    <dbReference type="KEGG" id="lpan:LPMP_090510"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090010300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_090510"/>
    <dbReference type="eggNOG" id="ENOG502S1JZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273796at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1099"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1194"/>
            <end position="1207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1480" mass="162843" checksum="E167440680F18335" modified="2014-11-26" version="1">MQLSTEGYHEELRLLRDTPELLSSGAQMEVRKVWRERRWMDDELEKAERRPSKSDVVCQHVVHGVASGIATLSSSFTPYHVSTTESGAQQRHVAAPMMDEVDEVVVMAQHVVFSVKDDEMASRFSTKHPRSIIAASAVETVQRVALGAMPPAQHAREQWLQEHAVRQHLTSLRRFSGSTSYELKARLARDVIAGRVDVPMQTAITDAVLNEQQGSLPSAGGSATTRRHALQDVYVFPPPQHSNSNAAVRQRRWCEGELLASTTPLIWQLPLRKPRMPTTPLWQRSRLPPGMWAVEAACKDVTRTEASLHASAVRDPLVVAKRPAAIKDSAEALIHHEGTPSCRETVATRAAAVTDAEPRHDNTRVRRQEAAAACVDGTENLYGLQYVWPSPLPPGGFIRVSPDPRFAMWPDSEDETGDGGLLGTMEKYGDSQARGLHAGDGGRINGDVGYSIARLSRGASQHQGRQAQMRRLARRVNHRTHKLCWLHSIGRISARYSDLTLSDSDGSSSGCTSPTASVLRDTRLAAEAKKANRKAPHLPMLPGDGNACRHQWRRQERVGDPSRRARPVYDGALNINIYAKVIQSQGNDVATDKGSSTGASPLRRASQHQHQQAKNATTTAHRFLGCYRQSRLLIHFKLYCRALYEERRLRCGGPGTHVIGRAGGNAPEYTPATEGLLAGVPVIPHPVLKLQEHAPSLRKPYAHRVPVASTMSGCRCWEGLYPPLGTDLAAPAQQAWRQLRQSILVRQALRDVYDELPHDKEGLLDKRTFVLFVLQLLELFFPTRLPVVAHIAIAEEEWAYRGTTEHVGPQTFHEKFFAFPLIFYRDAATLTEAPLVEFWTLIRVCFDAQKRMQKSAAPTGKCGDALQPSSLSLLMPLTHFTTEQLDTLLSCPPPAFDADVYDRYCLLRQAFRDDLKVRAAPRGHQYGVARALVKKRQQKKSLRHGHWTPQQRKSTGKPIGSLKVYRAHLGLADATRRIEIEAAAQQERDSRQRRLEEQEHEALLEQSLYYHARISRVQSRTATAISGIENVCSAWELHRTDVYPAPREDANDDARPREEEDVEELLLKYLDDVPLDAFDGQVSLRERYHLHVRFQQERRNHLFPSSQPRPEPSPSVTLADGGRSAALPSATPIAQTTSLRRRVKAESKAQRRTPGSAEARFLLDGTRDVSGGGGGDSTPPTVSYAAGTYPPRTVPRMMSPSRVRPMRGAPGTTSAARIPKRRAAHLSVSRVDGNGKIGSPSPFASFYATAASHWPHTRSPAARGIQREGLAASHREGGVSGLCPGKDGDDLLAATASGPSHISGRNTSFDCKGAAAPPRLLARPTTQTGWGTPCLPVSPLLAPHDGDAPISCGGSGAASMHVNARRDASPQLQHSTPLMPVTATSTTEPATTELTSIMFRGLDVEAMHAAPRSVPWIAQWGSTMTQDVGARPLRDPALSTAPVSAPLASLRYAQRLRVQRRLQQQFNRTAKATAGVTGNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJC6</accession>
    <name>A0A088RJC6_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MRB1-associated protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_080970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009377">
        <property type="protein sequence ID" value="AIN95905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704227.1">
        <property type="nucleotide sequence ID" value="XM_010705925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJC6"/>
    <dbReference type="GeneID" id="22572559"/>
    <dbReference type="KEGG" id="lpan:LPMP_080970"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_080012700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_080970"/>
    <dbReference type="eggNOG" id="ENOG502QVW5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="385235at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035770">
        <property type="term" value="C:ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000963">
        <property type="term" value="P:mitochondrial RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044528">
        <property type="term" value="P:regulation of mitochondrial mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23735">
        <property type="entry name" value="RESC6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050870">
        <property type="entry name" value="FAST_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058917">
        <property type="entry name" value="RESC6_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21228">
        <property type="entry name" value="FAST LEU-RICH DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21228:SF71">
        <property type="entry name" value="MITOCHONDRIAL RNA BINDING COMPLEX 1 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26188">
        <property type="entry name" value="RESC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA-editing substrate-binding complex 6 protein" evidence="1">
        <location>
            <begin position="1"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN95905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="442" mass="49887" checksum="6E5B2D46956B1CB3" modified="2014-11-26" version="1">MKKLHQERGGNPMLAQQARRVLFATSITGQNVDARSVALLLNTAVYFGMESDARVVRECIDFCLKNDKFISLDILPIVVTACATLKSRDAREVIELQAIKATKNARFLDAKGVTNIISAFSKTGINHEKLFRLLSMRVQTLARVGEFEAAHLVILANAFARLRYREQNVFSAIARRAMSLRERVTVNELVPLINAFSKAGLKDPKLSKRFAGKAMEYVDQMNAEQVAMMFQAFAYFGIRYDQLFGVLTNRAVELIDEFNAQYISTTLASFQRIGINNPELFDNLAERALAVVQDHDAKDISFTVTALAHFGLKDEELFKRLASHAASIADQFDPLGLVNTIHAFARTFFLQEDMVVALSERCVYVCRHLDANQVRRLLWSLAKFQVKDPRILAPVFNRCLALHQDFFSDPMGGEEIEEIFDVFGPNFCPPLYQLYMSRGSSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJE9</accession>
    <name>A0A088RJE9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial import inner membrane translocase subunit TIM22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LPMP_091130</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the TIM22 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009378">
        <property type="protein sequence ID" value="AIN96028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010704350.1">
        <property type="nucleotide sequence ID" value="XM_010706048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJE9"/>
    <dbReference type="GeneID" id="22572683"/>
    <dbReference type="KEGG" id="lpan:LPMP_091130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_090016800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_091130"/>
    <dbReference type="eggNOG" id="ENOG502RXYT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="75343at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042721">
        <property type="term" value="C:TIM22 mitochondrial import inner membrane insertion complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039175">
        <property type="entry name" value="TIM22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001838974" description="Mitochondrial import inner membrane translocase subunit TIM22" evidence="9">
        <location>
            <begin position="27"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIN96028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="233" mass="25521" checksum="06A5F7162A553539" modified="2014-11-26" version="1">MHCRRARSPSSLAPLFSLMFFLRLLGLSIHPPHRHHHSVITDLTAHRRCTMPTCIGVRCTRTASIVTCVGRKAHTNPPRTEMTSILDPRQPIEPLQRAMMVAKDSTLATAMLNVFGGYIMGFGFSLFGSMISAETSTQAMGTADFFRHSLRSAHRLAGSFAFFGFLFGGIEVALEKRRGRKDQWNPTIAGAIIGGGYGWRSYKYPGLAAGIVGGAAFSLVFEKMLDAMGMAQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RJR1</accession>
    <name>A0A088RJR1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exocyst complex component 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_110160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696865.1">
        <property type="nucleotide sequence ID" value="XM_010698563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RJR1"/>
    <dbReference type="GeneID" id="22572881"/>
    <dbReference type="KEGG" id="lpan:LPMP_110160"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190006500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_110160"/>
    <dbReference type="eggNOG" id="KOG2176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10267033at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.30:FF:000006">
        <property type="entry name" value="Hypothetical_protein_-_conserved"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.30">
        <property type="entry name" value="Exocyst complex subunit Sec15 C-terminal domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007225">
        <property type="entry name" value="EXOC6/Sec15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046361">
        <property type="entry name" value="EXOC6/Sec15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042045">
        <property type="entry name" value="EXOC6/Sec15_C_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048359">
        <property type="entry name" value="EXOC6_Sec15_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702">
        <property type="entry name" value="SEC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20651">
        <property type="entry name" value="EXOC6_Sec15_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04091">
        <property type="entry name" value="Sec15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exocyst complex component EXOC6/Sec15 N-terminal" evidence="3">
        <location>
            <begin position="270"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex subunit EXOC6/Sec15 C-terminal" evidence="2">
        <location>
            <begin position="633"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN96212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1044" mass="115648" checksum="3C8787EF7E5AAAD8" modified="2014-11-26" version="1">MCASNPPTLRVASRYTMESATPTKQDRRIYAVLRDHCDTPRVLFSTENPLLLVHQGNRRYVFLFSTKYYTYMVRSKGFKLYAVWANRQLSVTAQSHRVTLTSLDQRTIKATLQSYKETTDAAVNEFSTVTLETKSALNAAEVEKCIMCLVESAQRTAALLEQQERGIALHGSRHLGDNDDDAHSGGSSDSEDGDSGGTSISGARASAAARAAVQQGEGARKKKGAEGALRMGPSRYIAITSLVDGEFADYTTLKNAYMRHEEEDLLRDLGVFIKENEGQVEALCEHHYPALLHAAQQCVSISERDAELVGEELSGATTLVRTAVVNMKKATSNLLLSRSTRDNLQQVRSLLSKAIAVAEYLETAESQTQRQQLVGAVATLRELLRLAAPLSEYAIGEYVLHVRIPALTQDVFSYAVQHLNSWLRVLRDKAYPIGKASMEWGGTVTAGSLSSHLVMAEASEQWWLNEEFVPAQLKLAPFEEAEAITAVSNGAGIQVVFLELHREEYLDKYYTEGRWQQARTDLLECPLTLTNLSPAEVLSKFRQYCATVMGFILIEDIVHCATSPHLRSRAEIIQLWAILSAKITEHALKVLQVLLANPNETSEAVQQVQILQSLIHCAADNVKCVELNNLPLSRVMETASDQLISSWLQQACVDCMQLIMSDTFDPAVVTDAEQFAKLVTRFNFHRCTSLELNIPSTYTSSVQTLPYSAAVPRIGERVLGFLTQCYSTIIIDTSTAVMQSELNNVDEMLLKYMTVLFRTVAESMQGQLMSIDARAVLQLAVYATSCSMMPVLISCAEQQYMLHWQCEYEREKTQTMGAPKLMAHCVKFFAKSLQLGIERLLSALMKEVEERLKSVDSVSYWKARVEVRRQNRKADGDAFASCMEYILTMIPKLSSVLQSTVVRSVVGTAVMRAGVLMQSSLYTAITSAYQDGARDFGVWKDAIEEYERQCVMGVPLWQRRLGELLPGVSGAQRFPLNAVVAVQEARQWMDAKEQAYKAEKASQPQILAGIEGAGKAVAKGFQAVGKGVAARASAFGKGPQQQQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RK33</accession>
    <name>A0A088RK33_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein S21, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_110780</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009380">
        <property type="protein sequence ID" value="AIN96273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696926.1">
        <property type="nucleotide sequence ID" value="XM_010698624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RK33"/>
    <dbReference type="GeneID" id="22572943"/>
    <dbReference type="KEGG" id="lpan:LPMP_110780"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_110780"/>
    <dbReference type="eggNOG" id="KOG3486">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="278325at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1230.20:FF:000003">
        <property type="entry name" value="40S ribosomal protein S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1230.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001931">
        <property type="entry name" value="Ribosomal_eS21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038579">
        <property type="entry name" value="Ribosomal_eS21_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10442">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01249">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="84"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN96273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="157" mass="16306" checksum="2D9FB4A4AD1854C4" modified="2014-11-26" version="1">MATIGMFNEEGENVDLYIPRKCHATNTLIEAHDHAAVQISIANVGSNGVIDGTTTTLCIAGYLRSQGESDHAINHIAIDRRIVRIKTGKPKRASKSKSKKPAARGAAAGGAAAQKGARPSAQKGARPPAQKGARPSAQKGARPPAQKGAAPTRKSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RK58</accession>
    <name>A0A088RK58_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNaJ chaperone family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_100950</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696818.1">
        <property type="nucleotide sequence ID" value="XM_010698516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RK58"/>
    <dbReference type="GeneID" id="22572832"/>
    <dbReference type="KEGG" id="lpan:LPMP_100950"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100016300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_100950"/>
    <dbReference type="eggNOG" id="ENOG502S60I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001838983" evidence="2">
        <location>
            <begin position="17"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="15"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN96165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="254" mass="28744" checksum="E23E8D91DCFE06FB" modified="2014-11-26" version="1">MFRLSLLHRCLPIGVACRTLGFQAPPTNKHDLKKKFVQLTKENHPDLHADDEKAATARMVQLTEAYTSLKKLLEHRVQYRQGANLGQHRQGPSSAVANSESGTAARPHEDEWAEVATSFHTPGSSISLRGVTLPWQRAASNTVISSMESKLREPSVSFHEFVRYARHLEKHRQKREERIREDAATADGTHGFTAEYFESVQKNRAARRGTVRRGLPSTRLMALGAFYYGCRLRNAVAQAPRTAWRTLRYVFLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKT3</accession>
    <name>A0A088RKT3_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CW-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_140360</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697270.1">
        <property type="nucleotide sequence ID" value="XM_010698968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKT3"/>
    <dbReference type="GeneID" id="22573303"/>
    <dbReference type="KEGG" id="lpan:LPMP_140360"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140008700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_140360"/>
    <dbReference type="eggNOG" id="ENOG502SBBM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20839at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039715">
        <property type="entry name" value="ZCCHC10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011124">
        <property type="entry name" value="Znf_CW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13491">
        <property type="entry name" value="ZCCHC10 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13491:SF0">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51050">
        <property type="entry name" value="ZF_CW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Bromo" evidence="7">
        <location>
            <begin position="487"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="CW-type" evidence="8">
        <location>
            <begin position="738"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="133"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="691"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="780"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="861"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="780"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="815"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="866"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="891"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="918"/>
            <end position="928"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN96617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1032" mass="110210" checksum="A369F8A07860B52F" modified="2014-11-26" version="1">MEWPLSRVPFTNIVVEGEDGDDVNVTEVRQAAAGRITDALPHEMDALRQSPQQRRVQFTSLPASEVQTVHDVAPMWPELAASGDSNRGQATHERRLALIHAAAVTAAGSSTHDSSSVSKGTVSLSRTLLLRSTARSTQATTETPVQSSQPSVSLTKSSSRRRTLKDGAEAEGRVKRTVSSLKRTAIAKLGGATRQSRTGEDRTDKSVSRPIHARPARPSSASAASTAPTARQHATSEPPSPPLPSASPEEREAEAHRLTVQAARPPSLSVCFDWWMYLCYYDTHALFTSQATAFEVPLRPIAAASASVFYAELTRCFAAWRRQHWDSLVVLRGAGPVDSGARRRSAPTSKRVVRDPALLEYANAVWYEGLRVQRLMVQLLLSGSHGSWSFEVGCFDAVLTALGAPPSAESPLCPASPGSAVVIPPYRVTPAPPTGLTDTAANSPTTLVTVTHNDAAAAPLRTDGLSIHVPTAASTLSLLRVLDMVWNTLPTSIPFRMPVSEMEAPGYYRSTRDPVSLCQLYEEAFCGMTAPTHRACVRQHAHITRRLLEVLAYSSGRSSTGCAVEAEVQARFFSYAHLRERLTTLKANCDDYNGAGSELSQQASALLNTGVKALRDAQAEEDNRTTCQARGVDVLSVREEAHVREAPLSGPDKLATQQPYAVGALFVDELSSLMFPPSKAEVVVPPNLRQPLTVGERTADDSSANGQREGSRHSRLLRLPATGLSEIALRASPPTPTRASKIFWIQCDDCRAWHKLAKRLDSVPDTWTCASLGIVCSPAKAKKRKAKKRTKEATKPTKTSAGRRCRTRGGQDLDSTGGASNTASAAPHNAGGQSNDNGGVDDGDVPLVDVFPVAVRAAAVATAAKAPKRGRSISRKLHTARLGPKKARVALSTPPSSSSSPPSSSSPSSTSSGSSSDNDSRSSSRSDSSDSESDSDSGLSNGAKSKAAPVQRIPPAPRQTKWSTVATHKLPRNAAAAVTAKVAGAGASRPTDTALQRLVQEVAELEGRPLQDRPFDQLVEIKRLEKRLSAMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RKY1</accession>
    <name>A0A088RKY1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotyrosine protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_130660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009382">
        <property type="protein sequence ID" value="AIN96495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697148.1">
        <property type="nucleotide sequence ID" value="XM_010698846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RKY1"/>
    <dbReference type="GeneID" id="22573176"/>
    <dbReference type="KEGG" id="lpan:LPMP_130660"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_130010800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_130660"/>
    <dbReference type="eggNOG" id="ENOG502SCIH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10252009at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="556" mass="57700" checksum="BD95E5FAADF7DEB9" modified="2014-11-26" version="1">MFCSDTLCDTTPAVIHFINGISTACTSPSSGGSALQDGHCEQTPLPVMGHIFLTSLLCVSRLARKRQLLLQSVQLPASPPTASATPSVEEITAQSMDQPPSATAAGNTTFVRLVLSLLGQTMTKRAAPAPRASAPGDGNASPQAAPLPWWPATSAPRQSTQDVVYVVQCVGGESDGAGDNAGLCQAHVPSGGHAPVTSSTTANCRIILRSSPVPIFSSEMMAELALDAEQCASVASRTGYGSRAPGTDSSEDVDAEAVADSCVARALEVFDSCVRHHEEACLRQISKLGDLLEQLLERPAAEVHSAGEVASKGAPSATTTSDISQLGSCVSQLYEWTIDVPIYGVVLCVKDTHATRLERVHRLTTPLLQAATGCGDAAGGPLGPVTQTLAKLHTWCAASTTTASSTSSTSLGTPSCTPAIRTLTRSHVTELRRFVAGHFEKPQTAAARPLGPANPATVSYGASLASATPACIVHCQLGVSRSPSVVMLFYMDVFAPQLRAALSAAAAPLSIFDGLLSALVQARPQVRPNVCFAAQLLSLWKQWMRSGTPVGPAGVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RL11</accession>
    <name>A0A088RL11_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleoside triphosphate hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_140940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697325.1">
        <property type="nucleotide sequence ID" value="XM_010699023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RL11"/>
    <dbReference type="GeneID" id="22573361"/>
    <dbReference type="KEGG" id="lpan:LPMP_140940"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140014600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_140940"/>
    <dbReference type="eggNOG" id="KOG2702">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6362633at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN96672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="250" mass="27287" checksum="BCB0939DABE2E416" modified="2014-11-26" version="1">MIREAHVPRVLVAVAGRPGGGKSTIAALLANAVREALSDQPNPMAPFQKVDINDAERNSDASSSCAGLGSDSGVVVCVMPMDGYHLYRRELLEMPNAQEAVRRRGAEWTFNPTKLHADLTAIRTPNERGLYDDVFVPSFDHGIGDPQERDICIPSSAGVIIVEGNYVLYRGTPEWAAVNDMFDVKLFLACNRDVCKERLCQRHMQAWSISRSEAMVRASGSDTINGDLVDKTASNADIVMHSINASESKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLB4</accession>
    <name>A0A088RLB4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_141100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009383">
        <property type="protein sequence ID" value="AIN96688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697341.1">
        <property type="nucleotide sequence ID" value="XM_010699039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLB4"/>
    <dbReference type="GeneID" id="22573377"/>
    <dbReference type="KEGG" id="lpan:LPMP_141100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_140016500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_141100"/>
    <dbReference type="eggNOG" id="ENOG502S5ZW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4189at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097014">
        <property type="term" value="C:ciliary plasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF26">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 2 INTERMEDIATE CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="602"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="28"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN96688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="855" mass="87020" checksum="B9F80EE0F9EB08C8" modified="2014-11-26" version="1">MSSPKSALPPPGGSRNDGGRSPLPLTHTAAAANTAASSAASSPVTAVSPTTTAAQQGRAAAPSKHIAPSPAQVAAADGDVSPRSICVVSVSKESTSVCSAVDDSSDTSPTARPVAGSLRRSALPPFTPTVAAAPLTKGGLAASGGWDFLRKCMRVTTRDDTGDAVTQLVCGFNPSVLLGDVAGSVERSRRRVILDSASYLVPYDGEAVAQRMGSAATMSSSTVWSVCVAAAYGSCDSQAAMTGSNGGDLFINMRCHGGADPAGLDNRRSASALDPAFMPNTGGASLGTSLQRAGATAAAAAGVRTSMDCGYLWGSSFTTPSTVPRTTMESALAVAKESPGLVLTWFLVPLPASTIPRKEAPFTGATAAPGGGFMSNVCGDRTAIPEYIVILLPLVCDSEVTTLLAHPLQPSTLLGGTRCGRIVQWSSGQVWAQMEPRRLLERALATTGTTTTLLLPPQRPVHSSFPSPQAHQAPVLRMAIHGDASCHRLYSISQEGKVCTWTALQPLHPTASYLSYLGIQPMGSIGVTAQFVERAGTDAMTKVFIGTTSGALLVGANRDAKSIELQYYGPPRPLPTSSTVIGTLDVTATLAYPNTAAAASTASSRDVAGAAPPTPVTGSLEYPTGAAASVPEQGMYHRLAAMSSSSLATATAARRVLAPALQPHRGRIVSMSLQTAANGLRGCDCVVSAATDGSCVAWFDRSVTPLEGFSSAVTSVCWSPTKPGVLAAGDASGLVTVWAVNTSIITPVATVSLREAGHRVRGNTSSDGVLWVVSGPSDVAAGAGGVTAGGGTFGFDGDDDEADVVDSENVDASLGQADVVGAAISSVFFSCDGQWLFASTARGYVYTLHLAASLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLC5</accession>
    <name>A0A088RLC5_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_151200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697495.1">
        <property type="nucleotide sequence ID" value="XM_010699193.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22573540"/>
    <dbReference type="KEGG" id="lpan:LPMP_151200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150017400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_151200"/>
    <dbReference type="eggNOG" id="ENOG502S943">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267477at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="828"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1408"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN96842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1843" mass="195446" checksum="9FDCB747973B02BA" modified="2014-11-26" version="1">MEIDSLKIQLTNLLTLPHDSDTNEDDAVVVIFDYIHGAHKVANMLLLEERLPELQQCLHLCQAAIGEIALGPVAETTTAAADTASEEAATSAGAAPSTTHDTSGPLGANGKAVDSLLSSSLLPSSPGTTSKRRQTPLALRRDKDRHVFSVLASRTARLQKQLEASMRAWQNRNTNHHLHKLNLEFRDDGVDGTLDRCEAAASICFVQWQLQQLPRAAPMTLALPPTSSRGAPDSSAQMPAIRPPPRATRLSAPVQGGHGGSPSLRLPSLSTLGTFGTARQQAILAAPPPSPPPRRDIVTGERSNLNGWRPHTCLPPLATDSRALGEGRYQAHALAGGALHKRLQSTNHVGTPAAEDREVENDGGIRAAQQLYGTQNEDSISLYSHDIQEKLHRWSSSVAVTQPSPTASYHATQLVSRTMAVNDADEKEEADGWVVYDSDAGGCASGQVGFAPFQRPHTGWLLRAALSRLGSTASTHVPALSPSSPWRAGDGVPCTAASVFATGSHTPPPAQSPSNLVEAFTPRCRVLPVSTNAPVTTSSVANAMDSSTPLQLKAARGVPRDDAHAAISAASASILTPCSASLATPSMTSELLSLQSDATAAGSLPPLAGPATTTSTISADAARVVQAARQAMQFVMTSLKAQHHRTAQALEQYDDLALSRLSYSARQSLIASCARQATHECVGVRSSSTGGSGGDESSVWIASPASVDTPATPNCSLAAAVAVTIAEQHQLQHRRPLPPLCPLPSQQLSPGAEQQLRELHAECEQQLAASVSNVREMEARWLAQHRQLEACVALPRLKNSAECCRHHRPHPAQRSLYDPPQCESTCRRPGEQYSHSNSRGGGHARGAAPLHTFSVPPSPASPECKSPVAPTVMAEAAAAATATAVMQQGDDQSEDDEATLPALGPSHTEIVAPSGITAAYPFHAIADVSSEKGVSEGASGDSSVLRSAAETMRPVATVLPLAKHATQGTQESGDAAGTRIAVALAAASAQPSQQGRHSDAGGAAGHYTYNAAVDALVYARLTARTDAVPPQKARASLAVAAAAEESGPSTVEETLVAWRRMLQAMGSTSTTTAVVRGSGIKAVEMNVGAAYSCPSQASVCEAAVAVAQPPSTAKGDVRRMGNYIRWSADLVRGLRTQRVVCEALRQASKHVHPGDLVRPAWETVAAAHPQPSLLELPGVCLTDVDEAEASTKALVMCLTASASTTSPAPTGAAVTFNSAAPSPPATVGLLRDNSSFNKTSPTLSASSSQHTLTRWSRGKDIAPWLPSSVDTASTSPRDVTSEGSSTAAVTGVLRQLHAAYRASAMLRGVKDWTAVAPVLLARSLPLSVRAVRIQKWWRQRLAVRLCQQRRSARETYLIEEERLDAAALRLQRQIRVHWAQEASARRAAACAAWTEHRVAAERTSTKHSGFVDDLAGGSGGGGGASSSSQPVSRAHSAHIASAAEVDKGASIFFRSALTTVAPGDDDAVDGDRGRCEMACSSPSRTKTTPLSTTTPTEAVSAMALTAAASLPGHLGTASKHRPLPTHRTSGLQTPLELLNTAAQRIQRCYRHHLTAHTARLCQDVEVLSAVLTRRAPLAAIRMTLTASPTSSVALSVAASARESANAPDAPVMRNLLDLCTGDVYEAHLQRSLAARRHGDYKTALHHVCLRDLQRIRQEREREQQRWERQVLEVTKTIQRVGRGYWCRRWLHERGLKMRQSARHHQIEVPRCSPMSGLQSVQLLSPNGLGAQRAMSEDDPCAQLAGGEAVSSHIMLRLRAVHPQWFEIAADPTSAQYIALHRTPAQLAAVTITEAFVAAFASRAEVYNKYRHACAKSLQLAWRLHRAKLHGCRTQSHIVSASES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLC9</accession>
    <name>A0A088RLC9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Actin-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_151250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697500.1">
        <property type="nucleotide sequence ID" value="XM_010699198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLC9"/>
    <dbReference type="GeneID" id="22573545"/>
    <dbReference type="KEGG" id="lpan:LPMP_151250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150018000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_151250"/>
    <dbReference type="eggNOG" id="KOG0676">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270004at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="255"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="440" mass="47176" checksum="18B139F59FA0A071" modified="2014-11-26" version="1">MNIPLNTVKVLRNVPLPDEASVLHTDAAVLDMGSHTTRLGFAGDTAPRMRQRTCVVKGKATFSDACDVLDHVADPAAATTVLENGVIADWEGYEALLSRVARILDLENVESNTPVLVTEKALVPTHQRQKIAEILFETHHVVATSFALTPVLSLYASGLSTGVAVELGHDQSHVVPVFQGLALFHATHCLDVGGADLTRHFTSLMSAVASTRVSALESMTPTQRDGMWEYIKERHCVVAESAQLFSEINRADTRLGSSSSGLPPGGSRDAEDKHREECVLPDGTTLPISGSARFIPGECYFQPSLSPALQHPRDQSTVVDEVLLRTTQTPLSIPELVVDAMQRCDHDLLTTFASHIVISGGASLLRGLTQRVEADVQTCLAGTSDIHSAGSARVYADVERRDAAFVGGSIWASLPAAQALWVTKADYNEVGSMAVVRGCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLM7</accession>
    <name>A0A088RLM7_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">4a-hydroxytetrahydrobiopterin dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.96</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_100250</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:11920"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="EC" id="4.2.1.96"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pterin-4-alpha-carbinolamine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.96" evidence="3"/>
    <dbReference type="EMBL" id="CP009379">
        <property type="protein sequence ID" value="AIN96094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010696747.1">
        <property type="nucleotide sequence ID" value="XM_010698445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLM7"/>
    <dbReference type="GeneID" id="22572761"/>
    <dbReference type="KEGG" id="lpan:LPMP_100250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_100007700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_100250"/>
    <dbReference type="eggNOG" id="ENOG502RYBV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277398at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008124">
        <property type="term" value="F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.20">
        <property type="entry name" value="Transcriptional coactivator/pterin dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036428">
        <property type="entry name" value="PCD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001533">
        <property type="entry name" value="Pterin_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599:SF16">
        <property type="entry name" value="4A-HYDROXYTETRAHYDROBIOPTERIN DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599">
        <property type="entry name" value="PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01329">
        <property type="entry name" value="Pterin_4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55248">
        <property type="entry name" value="PCD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="243"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN96094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="281" mass="31879" checksum="C499507AC6F53E96" modified="2014-11-26" version="1">MLLAGLLRGSRAPTAPQRLRHSFRPPVRQCSSRSAVSSALTTQRAYKGDYGFNVFHNSNPQHGGSYARHERRMRDDEVEDFLKSVKHWRPVYEDVADGNVVNAAQSSSSSTSASDSEPPTPAFSQISEEAITRTFHFEAFREAYLFMGRLWAFCYGSDKCPHVTWEGTAITVYLYSPSFRGLSKREARVAAFLNDQYNMSRKSKWQQRRIMDGIVREAMVEKLLGEEVATHIARRQTLRTAPLQEVKDGPRSWRSAIGSPSHRNNKDSDREGTAMGEQDRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RLU7</accession>
    <name>A0A088RLU7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Tubulin tyrosine ligase, putative</fullName>
            <ecNumber evidence="12">6.3.2.25</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_160390</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tubulin polyglutamylase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.25" evidence="12"/>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN96913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697566.1">
        <property type="nucleotide sequence ID" value="XM_010699264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RLU7"/>
    <dbReference type="GeneID" id="22573616"/>
    <dbReference type="KEGG" id="lpan:LPMP_160390"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160008100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_160390"/>
    <dbReference type="eggNOG" id="KOG2157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2127950at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070740">
        <property type="term" value="F:tubulin-glutamic acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004835">
        <property type="term" value="F:tubulin-tyrosine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241:SF31">
        <property type="entry name" value="POLYGLUTAMYLASE COMPLEX SUBUNIT TTLL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="481"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="492"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN96913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="736" mass="80719" checksum="2CCF8957956E3A5C" modified="2014-11-26" version="1">MSKAAPSAPARRTTRRLGRRALATPAATSKLPRSPLSAKQKKKAEPTERLVASDAASAPAPEVDADPIERPPQQHLEQPADVADMDEVHLQLQRTLPPEDSDDCSDDAIDADSLSADLAGDAGNINKNSGAASRVVMPVTSLAGKRHTKVVMGPGATSGASNGSGHHHGDYTLRYRTDLNKQVIHFMFERYQQEQTHPTISAAFSSPPSIPNAGATEGVSGRMDESPRMNRSSSAVAHEAAAASSHVRARRINVEEICVSAHGDGDEKNIGLGDWHFFWMHVRRVRHTICSSAFRWQDQQIINHFPDHAELTRKDLMYKNIKRYLRENQGDNYARLTLHTATDWTSASANATDVEGAADSSTLASAGGERGRPLRVKSFCFADSVPLTYNIPNDMGMFKEKFQRRRDTQWIVKPTSRSQGKGIFLINDVRSLQRWMGEKKEVESISSFLATGSANRGPGAWSSVQQQQRPAFLSSMESAVATANSGGGGSPGSPTSPGFTTSTATFQAPAGPGSSGGALLGSYIVSRYISNPLLIGGKKFDLRLYVLVTSYKPLVAYLHEDGFARFCATRYAGSSLAQEDLGSHLTNVALQKGDEHYNTSHGGKWSIQNLFLYLQKAYGPYAAEGMMRNIQFLIYHSLKAVEPVMFNDKHSYELYGYDILIDDNIDPHLIEVNASPSMSTTTVSDRLLKEQVLTDTMKIVFPPGYPTSNKGMPYWEYRLRTDLTTQQQTGFKLLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMB9</accession>
    <name>A0A088RMB9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">diacylglycerol kinase (ATP)</fullName>
            <ecNumber evidence="3">2.7.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LPMP_161250</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic diacylglycerol kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.107" evidence="3"/>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN97000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697653.1">
        <property type="nucleotide sequence ID" value="XM_010699351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMB9"/>
    <dbReference type="GeneID" id="22573704"/>
    <dbReference type="KEGG" id="lpan:LPMP_161250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160017800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_161250"/>
    <dbReference type="eggNOG" id="KOG0782">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="242257at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037607">
        <property type="entry name" value="DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000756">
        <property type="entry name" value="Diacylglycerol_kin_accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255">
        <property type="entry name" value="DIACYLGLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255:SF54">
        <property type="entry name" value="DIACYLGLYCEROL KINASE THETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00609">
        <property type="entry name" value="DAGK_acc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00045">
        <property type="entry name" value="DAGKa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Diacylglycerol kinase accessory" evidence="11">
        <location>
            <begin position="348"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIN97000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="620" mass="66355" checksum="7B52B6D18CDC6145" modified="2014-11-26" version="1">MAHTIASCRGRATDVPTEDGVPSVPATPGQLAAKTARRFDGTASAPDLPAQSPEQLIDQYGRYYDSDVETSYHYMAAFINLDSGETGIGQAVLDSLRDVLGAKRVMVLCGEVFTNPASLRLLIKQQAVIYHSPGRSPRQRRGTVVAAGGDGTVSFLMTQLDLVRRELEAEFQSFLISSRQEVQLNSDNSVFSTSSVCDVTLHPYFTMPALAPLPLGTGNDYSNCVGFGCGFSPIAKGWCGLGALCKCSGDADAQVAVALSDAAKAPCVSFDRWEASLVPLRVAQAAVLSESSQAAAEAAQRGAPSALALHSPLWNRSARPRSVADAVCNVDWAKVHASGQCVTHGLINYLSVGFDAYVVKEFDSARRAHPAVCSTRAQNKAVYGVMGIRGALKCKKLCNIIPMVCVPRPKLSRVGGGAVATSRMSTTRDFVALQLPSMTKALVLTNVNCYSAGTHPWNPQSGELYYRPVTIRNGKVRPSVRTTTSGAAGATLPIPTPRPVTINDGAFELQAMGGVLHYTSLGIGLSNSTKLVQTDEMFVFVLCTPNDLHFPSGQCSTYTKLYMKDKYESRIESDGGVRASLNVQIDGEPMTRIAESTIIHVRRQPGARVLIRCRSPSVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RMG4</accession>
    <name>A0A088RMG4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Treble clef zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_180310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697865.1">
        <property type="nucleotide sequence ID" value="XM_010699563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RMG4"/>
    <dbReference type="GeneID" id="22573921"/>
    <dbReference type="KEGG" id="lpan:LPMP_180310"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180008100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_180310"/>
    <dbReference type="eggNOG" id="ENOG502RM8F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268955at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025487">
        <property type="entry name" value="DUF4379"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37317">
        <property type="entry name" value="BLR8090 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37317:SF1">
        <property type="entry name" value="ZINC-RIBBON DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14311">
        <property type="entry name" value="DUF4379"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Treble clef zinc finger" evidence="1">
        <location>
            <begin position="77"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Treble clef zinc finger" evidence="1">
        <location>
            <begin position="158"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="260" mass="29665" checksum="E0BB5A42691824E1" modified="2014-11-26" version="1">MLRPTCVLSAAEFKQKSRWSSVWPNMRYGAMYLNYSVGRQLPMRGVNWVTRDSNRLANFAARYGSVIRDVDVKRNEEELNIQMSDLRWNDHRRIYWKCSFCGSSYRKNVSVRTKFHAGCNLCKGRYASEVLREQTPVVALKEAQPELFKGLAENEKNENIGLLSVTSKFRAEWKCQSCGQPYRATIRSRTGLTEPGQAPLHPQITKWSAHCPSCAWRVNMTVLGRKAQKEGQYLGLDASLTEAASAAAGKRIPRRKRLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNG9</accession>
    <name>A0A088RNG9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_150520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009384">
        <property type="protein sequence ID" value="AIN96774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697427.1">
        <property type="nucleotide sequence ID" value="XM_010699125.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22573472"/>
    <dbReference type="KEGG" id="lpan:LPMP_150520"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_150010400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_150520"/>
    <dbReference type="eggNOG" id="ENOG502QW0P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1915931at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34553:SF4">
        <property type="entry name" value="G1_S-SPECIFIC CYCLIN-E PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34553">
        <property type="entry name" value="OS05G0597400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1462"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1513"/>
            <end position="1532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1568"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1701"/>
            <end position="1721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="674"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="788"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1093"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1264"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1819"/>
            <end position="1853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="709"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="805"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1109"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1169"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1264"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1274"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1310"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1328"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1819"/>
            <end position="1848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN96774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2034" mass="216961" checksum="F981E7EF0271A9A8" modified="2014-11-26" version="1">MLSWTSSNEPSSSCHLPVDTCCSSFLASSVRHERGDAVGTESYSLEGALSPTRTYVGRALADEMAETESLAATGTHKNAARVRGSSVGHGQGGGGAVEATPGGRSSSHSSSMPAAKEAPRTDIAHSRGDSPCVLVEVWPAHPQTHPGSLTSALAKGHRRGSGSRDDGHDGAEVLQRQQLSTLPITDMQSSSDTMGAAGVPHYQHAHRTAALPSRSPPSAQLSPTCNSPPLVLTAATELQQQQQHVYQPVPPSALEVTLPRILALRTPSLQRVVKDQRLTSSSSTLCTPAVACPVSPSTSISQSAAQHTRSPSPSLRSPTPLDLTAPPKYRPACRSDTVEVVEEIGEVEDPEEDGDVERRGNGAAAPRKSSQSTRQRPRKLSFSGRPATVTETHFATASPTEAGALDKACVAPSSSTSSPAGLYSDANASGAPAKAQATLVAAGESKPARISAPEANHTLKLATGVAAQQQLPPLSPPRSLSHPLCPSSPSLMDLGCPARLPEQQRLSSHMPVDANGHAHSASVPLPDPPATSTKAAPRVGTATTAAPLSVRHREHSLQHLQPQPSSPLRRRLHSVDCCGGGSVDDAPPCVPQVIPTHDSVFFPMGTDVIAPVLLHYLSIAGWSTTAGGRDYFNHRRLRGGEVAGHTVRWLHTAKPRDRFVFLVTPVVNREEAVLESDTAAAAEQRRRRGPSSITGASPSVGGSEGGVATESTLDMPSSGGSRKERMASHGSTCTATTKISRWGWNKPTNLLQMLHARVFGEAPWFTYNTKSACAFSRITQVNVDDSLSVSDAATPSGDILSDLSKDDDDDDDDDDGIIEGNTSGSKFCSEGAFRRSPHIRGSTRCLRQSLQYARIATVGNGGLREGTPPHSMSPTLSARQLSQSPSATVMGTVSSFTSLSPQSVRIAFSSPGSEHATAQNALHPIASARNSSTFATPSTGLSLVLPLAFDTQRSPTPAELQRISSVSRADSGIYNSYVWSHSTGTASAASMMTSPVTPGQPLLSLIPAASAAPSSGAASTTPATVGVEVVVVAHADVTAMDYASRLTSHRLSIEAKAAHTYFFPLLSDALAYYQCEDAMELMEEQWATGVASQIPRPHPAAPCYQRQEQQWERRRHDSHQSATRGGSAGHCTSVHTVPFPSLGETLVHEDSDEPNLLSSTSRGSPLTRADSHVCRVDGCRGVQRPRRSSAAPDSTRDTLWGGKGSEVARDSTATGVGLSGPPLGLHRHHPWQPHSTPTLPYQAALPPPQSLSLSDALRNVKSMRSINDNDSSMPSTSTATSPTAAPKNFHCRPFQHPLPSDPCSPPENSFAEHMRSIAPQGHEERSISRSGARNSGQLSLSSNAARSPLFLPCSPAAARTTAVSASAAPRPGLNSQPQLCCRSPVRPRLTSSHGEVVVSVYTADPVFNTILRELLVPEPGTHPYTVSVAEQKRLLSMVEVGMPAWSIFYSSTGLPYRRLFRLLYSCFTNLWPLLSLAVGLYDLYKHLPQLKRFMEHTLDPITRWMEERFTIRISVLITYLISVLVTIFSSLSSFVSQFYLAQLFSLPVVQLLLALLKLPFVIAFDTLWTLATTVLSTVSFVLQVVRMVVMAPLVLVTNIASLREALGAAVPVAIEGTSMSVKWWRAWMEFWETVASPMKNAARAWWDSMMHVSTSAARRETSIRRWTSPKLEQLAMAVGEMQDCFAINAQLWWPYVVLPGIELKVVLSVALVYLYWLFLVISPELWDEVIYASGVRHHPSLRRGQSASPPSMIATTASAPSLAFPATPPADSHVDAQYKGGNIDVCDDGRGMSASTRSVSVKWSLYAFFHDLPQDAESYSSPSPSSASMQPPSTVSIAKSPSPAGAGSTPPPFAMHLKPQQTFSALVVELLLPNMVLELLHRARSALVLGWSGAAVVASRMAARHAKSSLSDAPLKRSNASAGINAYCQCSWVEALSAVCFGNHTAAEAATATNVSGHGGPMRRYVNPLVVDVRWDGDEPFASPEELLHVWQAAVTAKWGDAVGRETRRAAAAMVAPQDDATAAGNVHVEGMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNH5</accession>
    <name>A0A088RNH5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_190530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698048.1">
        <property type="nucleotide sequence ID" value="XM_010699746.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22574107"/>
    <dbReference type="KEGG" id="lpan:LPMP_190530"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190013700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190013800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_190530"/>
    <dbReference type="eggNOG" id="ENOG502S4X6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="62528at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051493">
        <property type="term" value="P:regulation of cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000144">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010441">
        <property type="entry name" value="CH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052111">
        <property type="entry name" value="Spermatogenesis_Ciliary_MAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12509">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12509:SF8">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06294">
        <property type="entry name" value="CH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="2">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1291"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1389" mass="147619" checksum="587F38218537AF9F" modified="2014-11-26" version="1">MQRDVIKWVQSLDLSAPIQNPKRDLATGHLAAEIVARYSGTKYLDLHRLPNGAAAATKRDVWSQVYRALQQLSCTTVTQPLIDAVLQREPNAALTVLEYLYEHFTGQMLSMRGLDAVGTTEDAYVQPGNATRTARLLKVTCRNPNSFSIGAKGESSNAKALLFDPLLSTSPLARANRGCSPTNVIYSAHDTAADGFDTETAAGNDSTRALQHRLALIDNSELAGGANALQAYPHYARPTASTLVHTASGSRKDVVLDRPKYTADEALQRQQNTRIVQQHTVVQRLQGETHGEALASPLRTQADTAAWATDASLSPPSPLHNEAALYAGKSATATESLTALYRGRFYRQPDAPTTTRTPKASTLSRKAKNDKREEAGARRQRGAVAASSADHITILEDTVDHNGAAAPGNPLSTPEYLGSVSGGGGTDGPRVVPKLPVRVYSDSLQTALARRCSQANLQERATALSREHFAKHNYAIRPALSDILADVLAAHKQLQRLFDCCVEDGNSEVLDNVLGHLLAHRDEFPPACIQACWQALGQHVDGLVALLQRNPDEYGYLMESLTFAFSREAAQVPLLHISQTVIVSGDVDNAEQEKIAATTDASLLGLFLSPTRRSTAISSGGGVGVGCAAAAAASTARCRSPLRETASAAEGDLVSPRQRQSLSEALLTATHRAASVATGSFHVPPVAPLSSSRQMAIIDTRDGLSVACAFSFLYRLARQLDVRTATYVLERYVLRSAKPFLLRHGTVAVREAVARIVSATFVPAPPKDAATAEVVDSGAAAIAAAESEEAFAQFLTGTLAHTLLVSSPTAWNGNCGTASTSSGDIHQNSPAKCDVHGTHPLQLRVQRTYWLIVLHAVADYPYATDNGRAAHSDANGPLATCVRKGAMSCLLCTDADLLTIGVGLTVEYSERWLPRDMAPRGLTFDNAVTHARDLFSHVLPPLGSAGNQLSAPWWDTQTTNTWECRLMVLRLCNALLAHPLFAAAGEPSKASTEGSSDDDSAVPRSWRTIVDTAAAKCLWTFANTPSWQLQLALGVTAKSVDQTLTPALTNTWRQLLLGIPAASLLTQLLPYDEAPVRLRILRPLQLAEGIKYEAENDGRKGPQSSARQQLTLISSTKNNRAVPLQSATSALAGKPESWTLAPAMDNGDNSRDLGTRATAESALHLVWGRVLSAYAVLPFNQTWNAQGVVDAVLPPLPVSGGTAPTSSPPAALATAPALPLLVMAAALLSPPTTVTKTAPAAVSMDSPLGLSTSFADDVPVDIDEPNGAFWLEALRRAWPLFQACGASQVSMKQRAPRNVTEETSPQSGDDEEMAALSTGSTTVGSAGLGVHLDDLRTVVLSLFLRFADDAAVASAMAAAAGNGAELCGCAIRWAEELCSDAPTAVEQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNM0</accession>
    <name>A0A088RNM0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_191030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698098.1">
        <property type="nucleotide sequence ID" value="XM_010699796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNM0"/>
    <dbReference type="GeneID" id="22574157"/>
    <dbReference type="KEGG" id="lpan:LPMP_191030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_190016800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_191030"/>
    <dbReference type="eggNOG" id="ENOG502SHM0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267724at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="602"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="730"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="903"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="760"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="772"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="934" mass="96049" checksum="515B7B3650E9B65E" modified="2014-11-26" version="1">MQLSALPAGPSLDPQQPADQRQIVPLRDNGATVGDTVIPQLSTGTPGTVPRKASYTANLEAQVRVLEKEVHLLRAGLEQNEKLGRVSEITASLQRRSSTSPSSRQVHFGPSSVVMLSPTPQPTSTSSAAVTEVNSRPRLVFGQRVNPTHSRISAHGPSNADPWQTRRSRSFVKPSRTRTRAGPAPSSSTTPATSTTSVQLSPAHASLRGGNTNGIPLQGAATGGTLVSPVAADTQPAAASPAGSSSAPSAAATVWASADPRLLWPRAATAAAGTLVSASELSQYPFRTTTTSSPAAASRLVTSDAPAASSAPSVRALVETAGAAASPIEVAMSSDGPPLASLTQPAMPATSPAAEATPFPAAAPAVLPASSPSSLYTAHTVTHPLSRATVSPPSVAAAALSTDASAVPPEASASSSAPATVAQREAEALALRDTLAQRDALLHRLLLVLHDQNDNVGARRQRLPEKAATSPLLRQDAGAAVAALEESERQQSRKAMRFLTEELFAVQTQLSHARTSHQLVVAELHTCRQQVHQAPLQQQQLAATPEKASPDGMSQPSSGSLQEQLDVALKKLKAWEDWYATSATAAGDGAIGVTAGNSNALPSAKDASYPPQQLPQSKMDNTEKQTGVAAPAAASRGPQEKKRTHKREKCVYGAPTSGWCPHCGFGLPGLSPVPATSDFSPHYASLSSPSVPVQQGPPAVTPPAPYVSAYALNSILYNRLTNQGGGSGIGANGNVDAEPEVADKASGKAATPSPPPPSEAAPSSSPAQPTETHGKSKDARASEKTHAGTGHQSSRAGVCGASPMWAVPMSGASVAGAAGVGGASHKRAMNTAFLGGGAASDSSLSLYCDRLDHAQQQAYRTQQYVTQLAREAAVRELAEAERQVAEQRLALWEHCHSYAGSPSAVPSTPPFLAPCSATPDGPHSAEVGRQEVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNT3</accession>
    <name>A0A088RNT3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_200080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698207.1">
        <property type="nucleotide sequence ID" value="XM_010699905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNT3"/>
    <dbReference type="GeneID" id="22574215"/>
    <dbReference type="KEGG" id="lpan:LPMP_200080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200006200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_200080"/>
    <dbReference type="eggNOG" id="ENOG502S665">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271468at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="383" mass="42975" checksum="A0F2969B32F3D06B" modified="2014-11-26" version="1">MPSEDHSGLADVNPRLSSEHRYSMRAGLPNTSHRPQGRRHLDPHQFTNISDDAKRAEGRLGRAHVTSTEQQKRADVYYATKQPSVAQPPGTECNLFLKSYYYTPLSKQDSPSPLPRQRTGFRADAQNTSFQLSEARLRKIKSEHPQYKEEVMRALQDQHGDYSIVSTEQKISRRVAVEEYADGSDARMAHIEASNKYRSTPDLGTPSPAIQNSIPYALSEACPPRADTQLSCASHVRLYPGRGRSSSPPETPVKPCDRHLHDGSAPYDSTAVSGQAYPSPPAVGERRNIYAKPTLVHIDDRRHRNCVEDLDSLVMKRARARSGTSASQERSDFIFGPGPAPHACKPSLRYRTEARWKAQERSVEERRTGRALYPQSFKSTALW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNU6</accession>
    <name>A0A088RNU6_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Malate dehydrogenase</fullName>
            <ecNumber evidence="3 12">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">MMDH</name>
        <name evidence="15" type="ORF">LPMP_200180</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3 12"/>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698217.1">
        <property type="nucleotide sequence ID" value="XM_010699915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNU6"/>
    <dbReference type="GeneID" id="22574225"/>
    <dbReference type="KEGG" id="lpan:LPMP_200180"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200005000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_200180"/>
    <dbReference type="eggNOG" id="KOG1494">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4069699at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01337">
        <property type="entry name" value="MDH_glyoxysomal_mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000017">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000001">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010097">
        <property type="entry name" value="Malate_DH_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01772">
        <property type="entry name" value="MDH_euk_gproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF16">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="13">
        <location>
            <begin position="10"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="153"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="15"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="123"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AIN97510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="325" mass="34041" checksum="EB4F00926504C5CD" modified="2014-11-26" version="1">MRSSATLLSRVAVLGAAGGIGQPLSLLLKCSPLVTDLSLYDIRGGTGVAADLFHIPSPAEVTGFASDELEKAVKGADLVLVAAGIPRKPGMTRDDLFNTNAGIVRDLVTAVARAAPKAIIGVISNPVNSTVPVAAETLKKLGAYDPGRLFGVTTLDVVRARTFVAEALGRSPYDIDVPVVGGHSGETIVPLLSGFPSLSKEQVEQLTYRIQFGGDEVVKAKAGKGSATLSMAYAASDWSTSILKALRGDKGIAEYALVENDLQQPHCHFFGCAVELGTHGVERVLPIPALNAYEQQLLDACVPALSAELRKGVDFAEKTHLTPDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNW3</accession>
    <name>A0A088RNW3_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mitochondrial carrier protein-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_202760</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698479.1">
        <property type="nucleotide sequence ID" value="XM_010700177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RNW3"/>
    <dbReference type="GeneID" id="22574486"/>
    <dbReference type="KEGG" id="lpan:LPMP_202760"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200033400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_202760"/>
    <dbReference type="eggNOG" id="KOG0036">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="160"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="264"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="68"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN97772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="358" mass="39216" checksum="A90A7C8DBD94FBF9" modified="2014-11-26" version="1">MIKADGGWKAFWRGNTINCFKAGPEFAIVFSIRRYFSSLYEDCVVRETQRKKILVARWKAKEERSAGISRRGHGGCESMTMEHEESRSRTGGVGSQSSIDGVGSGCCAGLMSFVSSPSPAASVAQLLTRDELKLQERMILQEASIFTPPFNRLGCLSTVPQLVVNCTIGAVAGLGAQGILYPLEVVKTRVVVSRSNEYQGGVAEIVRLAYNRGGVMEFYRGFAPNMVGIVVYRGLEMGLYSSAQQSIMMYRMQVRKMSRHEASLNSAEIGVLGMFSSTVAQTVSYPLNVIRTRLQTQGTNGRANKYSGMMDCMVKMVRNKGVTSLFSGLTANYLKAVPASACTFVVFEWAQGLLVEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RNW5</accession>
    <name>A0A088RNW5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LPMP_160700</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="CP009385">
        <property type="protein sequence ID" value="AIN96944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697597.1">
        <property type="nucleotide sequence ID" value="XM_010699295.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22573648"/>
    <dbReference type="KEGG" id="lpan:LPMP_160700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_160011000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_160700"/>
    <dbReference type="eggNOG" id="KOG1863">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000316">
        <property type="entry name" value="Putative cysteine peptidase, Clan CA, family C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF687">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="142"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="613"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="827"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1170"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1411"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1590"/>
            <end position="1610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="627"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1181"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1590"/>
            <end position="1600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN96944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1749" mass="187065" checksum="3B8EF956B5A84E1F" modified="2014-11-26" version="1">MRALRAALPPALLRKAYRLQTPCMTKHTAKNDRLLNCTASPQCMVGLQLLGSDAATREDCLRAIMGDGPYVVPLPTVKGSSVIAASGDVASSSASSAREHGTARATKSTCEHLAEASQSATAADDAAERTVMSDPTFPCLWRGVRNLMNTCYFSSVLQLIFSIAPVRRAILDDAVGHDRHCVAVTDAQGGTGVSQLAESGLRELFALMAFSREGVGADPKSFATYLSLDVKVQQDAQEFFTLLLDWLRCHCGAMVRAAVTSTFSGTLLYDRQCGACGRSAKRAEPFLYLSLPVCSTLEDSLSEFSKPEAVDGFVCEKCGQTAVATSLQYMRTLPDVLVIHWNRFEFDPHTLQRHKVTTTASFPLQLDMETYMRQWHEQKWSNTSAAAGGDGAAPEQSEGHHMYELRGVVNHLGDTAVSGHYTYHGKVSSASAEPGSSSGGRSSSWLNFNDAEVSRLNRYQGQRGTSPDAYLLVYHRIPTPSSPSSASVSASPCPGKPLQPQPVAAIPSTSVAPIPAEYPVYLRQYVDRVNGECVAKRHHWTGQRAQVAALFDLWAAAAKAVFVNPTSTTSPPAWLSTAAAPPSLYVLPTLWLQHFGRFFLPAYVDAAALGSGPESQLKRNRKDSDAATGSTGDDTNSALASSAAGVGAKLIAVGCEEGASVSGTSVAVERAVATATVGFLRHGHMQTVEEVYQQVRQYSLLQALSSVTCAHGYVLPWASYKVVSASAYAKLTYFLGVCGSPLTVAASNDSSASSSTLGASMAARLRESLANGGSACDTQPSCAFTDASMCPLCVAAMAAGVQTLASRAAEDEEAELSLTCAWEESEQWKSHGAGGKNGEVSSSTGPEAAALTAGTQSTRQPEDAEEKADEQQQRVLVSKTIVEVWASFYASQLGWGRVRQSEGYTGVLVMREARVAPPPLPAATATASASSAFSSASSMVPETVSTSLANAGGPFSLAPLNVSRGDWDLSVQLLCPHGAVRSDQHVVAIPNSLRRYWVHRFVELLTVAHRSGALRTSSPHWSVNEDDIEHFLLPLIPASETSTTCRECMQSSVQHLTSRHEKRMRRMEERKRYPSLWLAGAMTSPAGVEQLLLATGAESEEQLLAAQHPNRLFFKHHGEREYREYVKKWSESHQQRVAHQSSEVQRLRTVLAKRQQRDAAWNARVTIRRCRRSRDDGRGAGEAANPPSTPTTVSPPEMATTAAAAPDPQSLESRLSHAEETLKKLMAQAVPDCTVAYGCVPTWWVARWYAAMQSEDSQSGTNKEGRDAYGEALLALPRISFEKLKCEHCASLLEVSWLNPSDCFWQGTRAKRAELLWNGVQVERAGASSATSPPTGHSAAEHRSQCWLPPMVILPMEEYVALLTQYGEPGMLERSTTSTGGSAGAFTAEAALGGAEPRPEVTDVDVEATADVASSEAAKEPRDPSASSTGNCKVASPSTPPPAAVPMTRARGPTVPVADAVIQVRFYNGVRQLVPPTCAQCCATMLANFDVHCESFVNGSLQLNIHVRKSRKNYYDAVSVLTSASVQHTGGSAVKAAEGVSSIVATKTDVIPAGIHYYTTLGQLRVYISAHLREKHGYLVPAEVLQIGRGKNKPLKRRSPPPHTTEGSAQLDDATLQELGIRDGETLSVQSVDIIAQTCATTEAIDEEWEAIPPELLQADARGGASAASAVREHTVAFRETRLQGGHGGSIPAASHAVSAAAVGVSGAVPTVGVASPMEEQGVTCCVCTFLNAPDMVMCEMCEAPLPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPI7</accession>
    <name>A0A088RPI7_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-tubulin binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_203840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698585.1">
        <property type="nucleotide sequence ID" value="XM_010700283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPI7"/>
    <dbReference type="GeneID" id="22574595"/>
    <dbReference type="KEGG" id="lpan:LPMP_203840"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200044500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_203840"/>
    <dbReference type="eggNOG" id="ENOG502TB7S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="297923at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023247">
        <property type="entry name" value="IC97/Dnai7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20929:SF11">
        <property type="entry name" value="DYNEIN AXONEMAL INTERMEDIATE CHAIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20929">
        <property type="entry name" value="LUNG ADENOMA SUSCEPTIBILITY 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN97878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="689" mass="78986" checksum="AB822D6BEEADAB11" modified="2014-11-26" version="1">MPPKAKAPEQRPMSKKALARQAEIDQATKEAQKTYKQHEQLRTNADQIEKGHREYLLLDETVARARLKAERRLYGAAVAELRAEEQFAFATYVKHDHWAHIAEASRLPNVHSEADINDFLSSWKCRQVTYDQYEPETVVVASRAQGGTGGLKLLFIRGEQRLEPQKRQALMKEELLQCYDAYELAEKIKDAQDTCCSVGSMALSYRAAPSTAVLEAVYRQLHATFDFVSTQMLRFYDQIIESADGETVMRTVSTEDPVVKFGLWVKTKDVTRSFTSLAFPDIEVRLDPKQNSLPKLPKMLGLSRENIAVRAVQLAFDPYSCYASRRSQFYALDCTIKIDLLTFDERPRYSGDWQLREETPESHRLHIEEYPPRTAEARVEDPALRISFEVPHTIVIRQSSLFIGRWNAETHEWEPCSGATLGASFGPTARVAENPRRATFEVAELAQFAVLQETVYDVPYESWSLKPFDSSRILFTLEGRHRGDSTDREFRVLLEDAKCRLLSPEDNELAALRSSWWSPAVLLRKLKQSGFNFLVRDEEACFLENITPKSLQLEEKAYADMAQFSQFFTIASSHHNKHGEDADMALFRVSKRWLQLGEEDETFDIPTAADLWHSVRYRTDDCALACFTETDEMTNLNVLDGTETHYNLYSLLTPLEGEDALRGQLFNTNYLLRRCVLELLQLVRPLTWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPS9</accession>
    <name>A0A088RPS9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Membrane transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_210110</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698799.1">
        <property type="nucleotide sequence ID" value="XM_010700497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPS9"/>
    <dbReference type="GeneID" id="22574833"/>
    <dbReference type="KEGG" id="lpan:LPMP_210110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210005800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_210110"/>
    <dbReference type="eggNOG" id="KOG2563">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="422206at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049680">
        <property type="entry name" value="FLVCR1-2_SLC49-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 49 MEMBER A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="420"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN98092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="457" mass="50635" checksum="7C30D67EE8F3BB26" modified="2014-11-26" version="1">MMITDLFSLIEKKYQVLLIFIIFTVNNGFAWLMFEPVADWLKTNVHGMTSRTLQLLSSWQPLVFLCMFIPIMKLVTRYDGLRLAVRIGAAAEIVGATFKLIGAFAHKSTFGLVMLNIGQIFSGVGSPVATGAVSALSATWFEPEERTRATAAAVLFNSVGNSLCYIFVPTLTKKLSFSAVTVYELFMAVISLSLAWMLMPQEPEPTEVDTEGKMQTILQLSATSNSKSEGDVVAHSKEHLSLVTQLRSLWSIPSCVCLLVVYVWLSGGFSAWISLFADTYSKFYSEEFIGIMSFFGMISYVVGGIASSYVVDLYFPRQMKYVIFFCITMNMLCNLIFIACTPNDRSYSLWNLGQSFIVFSTALCGFWNGAAAPLFYELVAEISFPVEEGVSGICISVMENVGALVFYQVVSRFFTGQSMTVAYSFGMTVAVALSAAVKQRYNRSYHAYLLQNAEGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPU0</accession>
    <name>A0A088RPU0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LPMP_210210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009390">
        <property type="protein sequence ID" value="AIN98102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698809.1">
        <property type="nucleotide sequence ID" value="XM_010700507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPU0"/>
    <dbReference type="GeneID" id="22574843"/>
    <dbReference type="KEGG" id="lpan:LPMP_210210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_210006800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_210210"/>
    <dbReference type="eggNOG" id="ENOG502RSXM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272137at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040000">
        <property type="entry name" value="NOP9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="637"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="685"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="688"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIN98102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="769" mass="83134" checksum="FDD6DCB7C476C3E8" modified="2014-11-26" version="1">MPPSAYWGKRPREGDSDEAFVRFSELSPARKLERRREERVEKKERDRTLAYFRSVQRALEDQVTGGGDPSTLASIVDGFFSELLKLLKADSTFYILRNGTACRVVELALANALLLHVKSLLYVFLGHICELLISPVASYTLETLLASLSQGLSALAGTNREGLEAELTEGGVGMHTGSGVPSSATLLSSMAEEMCEHAEDLIVHDIGGRALRSVVLMLGGRPIRQAPLPNRPVAFPRIVGTLAEAVTKALEEGYGREYQTASPAEAWMAAAQVPATSLVMQSLLRVSDEGTVVERCVRQRIEQLSYKGKPLLHHLLVDKLGCHLFQSYLQVPPPTAVVVEGDAAAVHASASTVDSDSSSEATSAPGGDASCCWSRAAGSITVEVNNLLKPGSDLVAQTGYVLQDLVLYAPTATHLQWLWRRVLEPRLALLFDVPALTPVLVQLVKRCAFEGVLLTPPAPSGLAVATAQAGDAAASATEEVSHHGTTLPADVLTMLRNEVAQHVRYSPVPITFQGEVCASVCTLAKQRVVKGAAQYFLVDAALGNKGYEVAHFLLHLHPTASTVLQYSLDKLQRDDLLAVVCHQKGSLFMQQYIKVTALAVSKSTATRTGSEKADPTSGGADAAAAELKRPLMRLFRRLQSSLGTLIYDKYAAFVVEGLYEAAAMPVKEALVKSLVPLYQAMHTQHSGTTPAPSASAEAVPSTASATADDEAGENVKHATPSPIQQRFIAYKVMSKCFVEQYVHRRDDWIKLAKRQCHVQRLLCRMLLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RPX9</accession>
    <name>A0A088RPX9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras-related protein rab-5, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_181130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009387">
        <property type="protein sequence ID" value="AIN97294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010697947.1">
        <property type="nucleotide sequence ID" value="XM_010699645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RPX9"/>
    <dbReference type="GeneID" id="22574003"/>
    <dbReference type="KEGG" id="lpan:LPMP_181130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_180014600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_181130"/>
    <dbReference type="eggNOG" id="KOG0092">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002076">
        <property type="entry name" value="Ras-related protein rab-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN97294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="236" mass="25265" checksum="68CE397B0138E9B5" modified="2014-11-26" version="1">MNTHPPQLMEATSAKIVMLGESGAGKSSIALRFARNEFLANQETTIGAAFLSKTVMMPPARGAAAAPGGAASAHALQQQMRVLKYEIWDTAGQERFRSLAPIYYRGACGALVVYDITNSESLKKAQTWIKELRANADPSLIIVLVGNKKDLESLRQVPFEDGQRLAAEEQLAAFYETSAKDNNNVEQVFLDLAGKLLDQGLGNRGGATGGARGGVIAPRGERVEQHNESAAQSTCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RQD1</accession>
    <name>A0A088RQD1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_191170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009388">
        <property type="protein sequence ID" value="AIN97459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698112.1">
        <property type="nucleotide sequence ID" value="XM_010699810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RQD1"/>
    <dbReference type="GeneID" id="22574171"/>
    <dbReference type="KEGG" id="lpan:LPMP_191170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000040200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_191170"/>
    <dbReference type="eggNOG" id="ENOG502SCBD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="259903at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38827:SF1">
        <property type="entry name" value="T. BRUCEI SPP.-SPECIFIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38827">
        <property type="entry name" value="T. BRUCEI SPP.-SPECIFIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN97459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="121" mass="13029" checksum="9AAEB9FDE46F3574" modified="2014-11-26" version="1">MFGRRVFASAPLPRHMWPKMHIQNETQARRTLPSFTPLAVAGGTRSIFCSGLAFNALCRSSASLGGEEGLVSPDGKLVSAEVAAACAEWCAQALRTTILPIHHLAASSPHSKCLTWQTKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRB9</accession>
    <name>A0A088RRB9_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytosolic carboxypeptidase-like protein 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP/GTP-binding protein-like 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Protein deglutamylase CCP5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LPMP_202540</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + H2O = C-terminal L-alpha-aminoacyl-[tubulin] + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:63796"/>
            <dbReference type="Rhea" id="RHEA-COMP:16436"/>
            <dbReference type="Rhea" id="RHEA-COMP:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90782"/>
            <dbReference type="ChEBI" id="CHEBI:149556"/>
            <dbReference type="EC" id="3.4.17.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:63797"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>gamma-L-glutamyl-L-glutamyl-[protein] + H2O = L-glutamyl-[protein] + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:60152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:15517"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:143622"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:60153"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Midbody</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 13">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009389">
        <property type="protein sequence ID" value="AIN97749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010698456.1">
        <property type="nucleotide sequence ID" value="XM_010700154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRB9"/>
    <dbReference type="MEROPS" id="M14.025"/>
    <dbReference type="GeneID" id="22574463"/>
    <dbReference type="KEGG" id="lpan:LPMP_202540"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_200031100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_202540"/>
    <dbReference type="eggNOG" id="KOG3641">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253041at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06236">
        <property type="entry name" value="M14_AGBL5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.3120:FF:000004">
        <property type="entry name" value="Metallo-peptidase, Clan MC, Family M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000118">
        <property type="entry name" value="Metallo-peptidase, Clan MC, Family M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050821">
        <property type="entry name" value="Cytosolic_carboxypeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034286">
        <property type="entry name" value="M14_AGBL5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040626">
        <property type="entry name" value="Pepdidase_M14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12756">
        <property type="entry name" value="CYTOSOLIC CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12756:SF46">
        <property type="entry name" value="CYTOSOLIC CARBOXYPEPTIDASE-LIKE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18027">
        <property type="entry name" value="Pepdidase_M14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M14" evidence="15">
        <location>
            <begin position="374"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="220"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="818"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="818"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="829"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="848"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="13">
        <location>
            <position position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AIN97749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="887" mass="96821" checksum="4128FAFA84D0EA08" modified="2014-11-26" version="1">MGLRHSTCSQQSSPKEASSRRPSVEGHRDASQHTPKSSTFPSGQELTPDPSRNEPSDAQCETPESHAHAAHPTVQGPQVSDAFWVFQRPPNNQRTFYFKEDNLEFSSQFDSGNLIQVERVDAFQYRMYTAMDCGNAPWQTNNRQWFHFSVRGGSKDAIVTICFVGMAHSNMFTYDWMPVMAVVPTRPQYSRITGKAHVEALETMPETPGYPLLMHKPVLKDDADSDRGGDEGNNDVDDGSPATTSNGATGGTAFSISPMSKASGTGTKKKKKKNVAMNLTFNFKIEAEISVTYTPPQGRPDAPAIYIASNHPYTYSTLQCNLATWQEEALRSSAMQENSVQVPDYVVLRSISEEGGATESHCRSCLTKAPAGSSVKSKKRVGSSKTDNVALSYVGAHSGIYFHREVLCKSLEGRDITLLTISDCSGMTMERAHLISKEVGLPYSSALGQTERPFSFSGKQYVVLTARVHPGECPGSHLMHGCIDFLLNCTDSRAAALRRNFVFYIVPMLNPDGVVRGHSRVDSNGVDLNRMYRDPSPKQHPAPYAVLALLRSLGSHVTLFIDMHAHANKRGTFLYGNSMGWVNQIENLLYAKLVALNTPYLDFRRCNFLEANMFAVGKSGKRKDSSSRVVAFTETGIVHSYTIETSHVMADTLNQVIPMTGYQAEQLDTALPSPLPVMHSPATFRDTGRAMLLGLLDIKGMNPISRLTFTQFHSTRGLALWLQRQLQIESAEMLFTQAFKKHGKEVQATTSESGDALLTAVMKSLTAEEYPDKITIKGARLLPRTTFSGVRSFVPLETAIVLLLQTAPTGPPRSVLYGSSSGATANGATAGGGTDGKGGGDTLRRGTSPATGINNGNRGPNVIPPAVIATRRRSKPNVTPESTRVEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRH8</accession>
    <name>A0A088RRH8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribosome biogenesis protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_240570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699399.1">
        <property type="nucleotide sequence ID" value="XM_010701097.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22575466"/>
    <dbReference type="KEGG" id="lpan:LPMP_240570"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240011600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_240570"/>
    <dbReference type="eggNOG" id="ENOG502QRXZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272231at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039844">
        <property type="entry name" value="URB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021714">
        <property type="entry name" value="URB1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500:SF0">
        <property type="entry name" value="NUCLEOLAR PRE-RIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500">
        <property type="entry name" value="NUCLEOLAR PRERIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11707">
        <property type="entry name" value="Npa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="URB1 N-terminal" evidence="2">
        <location>
            <begin position="312"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="827"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1202"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1718"/>
            <end position="1783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="867"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1217"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1718"/>
            <end position="1732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1743"/>
            <end position="1756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1783" mass="194607" checksum="59594145077630BC" modified="2014-11-26" version="1">MALVEPLVGHLLSKYKETVLEGLSKIRQILQAGGEQANELAVVMSQREEALQALRATLLRQEYFVPTLQTLTVVLTQLVERGNRVALAREVLRGDCAALFRKTLATLSDATLTHVTAALQFLTVAVRDAPLLVLARLRSPADSHSAPAPVHGASMVPLAPVGTQRRADVPLHLAVFRLQLTYNQRRIRLTRLGFLVELLTSPMHNAVVDTICSHGILTHLLEDAAELLREGTSAGTACALSALRVVRELFVQSRHITAEQKRRVLLGQRNVFRLLVRALEFDPVADNATAILYAIVDETIESPADYASTRVESLEDQGMPNYLLFFLLRQLRPKTSERMSRLALHVLQRAPDLLRPYFIRISGHLSEEGNSHGVAPTTSRVAVLNLMTRIFLCPMPYHLAAKQVRLVSVVAKTSTFYTMCPRDVTDEICPAWVAEYVHRLINGSTNLLMLTLAMQLTQAALMRAKRVLPLVLAVQIAAKAKKTSAAGDAAAGDAAAGSSARETVFSLPSPRNFTEADLDILQGRDDAEAEVWDAYNAQVLHHLQAALPSREEFWHRMTQQLHRTLTAAASASTSSTTSPSADAIDAILVKTHVTVQRMLLLMKNYVDVFDVRVPWLSAVPTFLPDLSRSAVSNNRSAHGSIAVKGAKGNGTAVAESVHPITAALQQQNDILKPWPAASVALLCELLTASQRRRVPMMKMHHINISQRVGIGEWPLLLSVLLWVAHHQPHTPPRPESMEAAQEARAIGWAAQLLLWTAHSVTIHSTCTMAESHLWLSCLTPNTVPVFLHVLNHLLMRSLSKAADRVTLELQDAPHGVLAAAAQHFIDRTREKQQQKGSTRGVEDEGEDEQQVQQQLRRPKKSRAECANKSSGDNNRSSSSSKSSSNLWGTHLQASLAEFESVLARVVQLWERRVCLLAQGAAAMTPELDMPRVTQQQCIDVLVLADRQRGFTKTPLRYGSISESAHLRTFAFTLQSPVLPLPEEEAAMTLLSRLSKAISSVLPLGKEEQDSTRKHTPMNFSLVEDVCAALGIKDSLTTCSEEATSPTPPWFSMSSVCWQTTGMLLSLTHSSGTTPSSRSRGTAETARTLSLRLTRELLTDEAALTAHLRANADREGSLTGLLVLMLACTRTLLQLTALSSTEQQNPRLSPDECAALGRVCLDVYNGTLGVQDRLLYAICLTLHYLSATHDVAHPAAAAAGAATATMEERDDEAAARQQGKKHRAAAAKHLSPHHHEGAEVPDALVQRRFLLCGHTACAARTPELEMLSWHLDTLTEEDMTGMALHASSRLHNAIHVEDGSSANGATDWLGAVFPELRSAGDAHVADLERLSMGNVLDLRYIVPLLHRVAAMPAIFWVHLSTGRVIPLLLKALTSIDAQLRSAAAAALSTLYIPKGALRVVVSVARMKLTQAQMTPSSHGTGRQLHQLPQPHHASSAAAVPRLPTPLATMLIMSIRPLGHYDDILHHHLVHFLMKLESALDTPLPFAHWAITPPLAAISVPLMLERQEALQLHTNKLGGGSDKRSGDVTQASVADVAQKLRKEIPPQLAFLLQLLRHACEVPEDGAAVIESNGLDGLMLLCDMLTASDGQRALYVQCLLVLCTQSAALTHMFTRSGHVLAWTVSFLWQLCREYGKSTPHPYSGPTFTTALELLRVICAATVQSTTSFVDTLGLGGAVAEQLPESVRQLRAWVVDAHVTARDVLDVFDEIIARCSDAVHGQHSSATKVDDTNSTEGAAKAKETRASSLEPPSQSSSLPSFEKRRRDAASWRGKCNPPKRMRAESTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRQ5</accession>
    <name>A0A088RRQ5_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coronin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CRN12</name>
        <name evidence="9" type="ORF">LPMP_231300</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat coronin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009392">
        <property type="protein sequence ID" value="AIN98580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699287.1">
        <property type="nucleotide sequence ID" value="XM_010700985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRQ5"/>
    <dbReference type="GeneID" id="22575335"/>
    <dbReference type="KEGG" id="lpan:LPMP_231300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_230020500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_231300"/>
    <dbReference type="eggNOG" id="KOG0303">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1850764at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001430">
        <property type="entry name" value="Coronin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015048">
        <property type="entry name" value="DUF1899"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF0">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08953">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16300">
        <property type="entry name" value="WD40_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01166">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01167">
        <property type="entry name" value="DUF1900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1 4 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF1899" evidence="8">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="121"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="398"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="472"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="416"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU280818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIN98580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="510" mass="57195" checksum="D8AD4045F1E58D22" modified="2014-11-26" version="1">MSVSRFRHSTGHVAKPQRQLLNVTSSTALWDGSNTISCNDKFVAVPWQTLGGTAVFKHDVSGRLAPNPPIVLGQEGPIIDVKFDPFDNQKLFTASEDGSIFGWGIPTDGLKSNISSPLVELKGHRKKCGIMSFHPSAKGVLASAGVDSVINVWDVERGIAVTTISNLSDYATGLEWNLQGSLFCTTSRDKVLRTIDPRNSTVVSSVESHASARSQRCVWCKRKDTIITLGCNKSQQRQIKLWDTRKLEKAYSVVDLDQSSATFIPVYDEDINLLILGSKGESNVKCFELMDEGLTFSYEMSSHDPMKGLCIMPKWSLDVRKCEFDRLYQLTYHSLLTIEMLLPRKQSCIEFQRDVFPSTFADHSAISADEFFRGTNATPREYDLSDLFNGLSPRLLGESKSSFQKTPVAAQAAKPPMKEPKEETVTRSEHCAVSTPAQHEGDASPTNDRTTTHVDPWGHMEQEENFHRKKRFQELLEKVRTCHQEIETLRKALQEKESQMLKVLEDIQSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RRW0</accession>
    <name>A0A088RRW0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_240530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009393">
        <property type="protein sequence ID" value="AIN98688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699395.1">
        <property type="nucleotide sequence ID" value="XM_010701093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RRW0"/>
    <dbReference type="GeneID" id="22575462"/>
    <dbReference type="KEGG" id="lpan:LPMP_240530"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_240011200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_240530"/>
    <dbReference type="eggNOG" id="ENOG502SPNW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272386at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN98688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="130" mass="14829" checksum="B7944E9DDC6D9050" modified="2014-11-26" version="1">MSTDLECGSERLGRYTCKDAPRPSVCCANGCCAISPYEVDIYTGLPLWLRIAVAILAGLVMVLLFVFCLYRDRRALRAYRLLDNEMVEERRQQLQQEELQALHPTEPRHGENEASRMPDAQSYPPLRRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSE1</accession>
    <name>A0A088RSE1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RecQ-mediated genome instability protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LPMP_251840</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699754.1">
        <property type="nucleotide sequence ID" value="XM_010701452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSE1"/>
    <dbReference type="GeneID" id="22575832"/>
    <dbReference type="KEGG" id="lpan:LPMP_251840"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000017300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_251840"/>
    <dbReference type="eggNOG" id="ENOG502S2KR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="341511at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.770">
        <property type="entry name" value="RecQ-mediated genome instability protein Rmi1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042470">
        <property type="entry name" value="RMI1_N_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013894">
        <property type="entry name" value="RMI1_OB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790:SF15">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1 RMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08585">
        <property type="entry name" value="RMI1_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecQ mediated genome instability protein 1 OB-fold" evidence="4">
        <location>
            <begin position="88"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIN99047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="503" mass="53684" checksum="9076E40A358CC38B" modified="2014-11-26" version="1">MTAGTDEATVDYIRNHLDEDLEAVAQQPGPPLIRPSLAPFLTSAGLFSLAGVAPQQHSLAPSIRNRGSSVDPAHPDGSPLSSAAHTVTFILQVMSIKDVSLSCEQRSRALLHSLSSTCSSSGAMSNGAAIDMDTDTLTSLAADATPQMMEEQQDEQARQHTPLLPSGGQWRCLRLELSDGFQRVLAVEDASARTRQRYGGVLAKEGISLGAKLHVCLTASLADTTATTVPCVQHGVLRLHAGNTEVMGGRVKALEVYWEAQARLQLAASTGRPSKQQQQQYQLPSLPDGPTTLASVPPAQQQPVAAFPLTSPAPPSQQQPQSPAALPLQPLRCWPAHAAQHPPHVPFCTVAFITEVVSDMVINEPSPGTTHNNHHVGADPNPARDAFTYSLLVQLSSPSAVECETPRHLNDTPSRRGEELGQVSEDDHLIVDLGHAWLHQLVGMPADAFRMLSLSNAAADVEKLTRTVEAVGQALEQFGKGCFTLVRRARDSIVEVVHAVPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSN0</accession>
    <name>A0A088RSN0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Serine-type endopeptidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LPMP_260120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699834.1">
        <property type="nucleotide sequence ID" value="XM_010701532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSN0"/>
    <dbReference type="GeneID" id="22575915"/>
    <dbReference type="KEGG" id="lpan:LPMP_260120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260006100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_260120"/>
    <dbReference type="eggNOG" id="ENOG502QW78">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276526at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="6">
        <location>
            <begin position="74"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIN99127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="235" mass="26683" checksum="111520E014935F60" modified="2014-11-26" version="1">MPSYAEITGSIMAMVLSTDQTLFVLYHHNSYAVNPVMLRSSKPMVMRDVFLTRSNASYPNPLSCLYVTNGTDCFVNCVMAWVVAKPLTEVLGWRHAIALYIGAGLFSSFAYVFAAQVSRTKTTSQFDCSATSNGAYAGYATLSLVMRETYIPYLKRVPIMWAGAPYLLKCTYDEYVSPRLVERRRVGDIELRNWGFIGGVFFTLIYSSLLFRTRRDFNLARTFFQNLHQRVAARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSU1</accession>
    <name>A0A088RSU1_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_251800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699750.1">
        <property type="nucleotide sequence ID" value="XM_010701448.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22575828"/>
    <dbReference type="KEGG" id="lpan:LPMP_251800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_000034500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_251800"/>
    <dbReference type="eggNOG" id="ENOG502S4R9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273709at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1486"/>
            <end position="1558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1486"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1509"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1539"/>
            <end position="1558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1558" mass="168917" checksum="56A390D658219E3C" modified="2014-11-26" version="1">MEAGQASSSDVAPWWWSHRSIVEEAEPLDATADDAAASCLSAIVKQTANHVLAYRNVLLDTVSVVQDAQEGSATSGSQHSSDASHINLYQHMKWDGVLLPLLTQLRKCMARAWEERAAEQAEQAADGMTPMSASGVGRGSFKVMPTAHVDAVQARRLRAVQQQIYLAFLNAVLQGLTDGARAAVVTGVDTSNSAACEEGGSADAQPGSSSETTDAAPAARALSLLMDSLLTHVLSFATSGTVVTSPQTETEDTTKPRRGQHHRTLALTCTHTGDWFTGMLPLYLRAAYQQQQQRAHDGVAEQEGAASASRSAALIPSPALCLVSYIGVFVQGAGLQLFPSEQEAYLPCFNRKVLSLFSDQIKGFVQAAVEQSEYVIAGTTSTDAVAVAAAHIRYAGDVLKAIIDMQLYSEDNATEVGEDDCTMVYAALPCPLALRAQTQQSEKRTEVDYSVAPLLALTSYKVCERLLGLMSRWWVTCERMARHARTCVAAAARRMDEDNVEGEKQEQQQQGADSPTSGNDTSHLAELEDVWLGLRKQAMSFTLVLSTYSETTLLIVPYTALLTDLFFTPAPDRSAPSGAQQAPLSLETWKSCIRELHRVTHASQDGSYALFTHTACGARRQLRMHHCHVRDCTFAAACFSRAMVCLSDPSTGAHVSGCATEVGTDRQVHSSGPHSLLPLAFAALQQPLSVMQEHVFHPLLRVSSVTLSVRADAVVREKGGAGQHGATPDASSATRLEALTENPLSAVQLVELYFPRHYRVMSALDQAMQYVLDRFQALASNHTALEETVDSEVAMAWASLCSLPATLTSFWGATMDEACVSRMRNTGDEVATSELLMFFAAVFRTLPPTVLPRVRAALETFLGEGGCKTMEYLRHHIIDQRRHGLAAFFLPPLRAMALDYATAEDADVSLALAAKYPSGCAMAYAWELPRLYFWRVEDTPVVAAAWHAHSAAQRYLCELVTADSAISTTSTAPFLAILQGAAVVVSERSAAPHESAKTASGLFWTRSLAIDVMGSVFFGMCRWCALQLSASSSSLSAEAAATVIQQLCCPRTPSVVLSSPHAVAHPFLLSLRNHVKAQVGNNLADATEVEGAVVSKENAEDVDLPSVASPSPSQQLLRSQHCWISWFWACTYQEVDSTARVQAAAKRLLREFSAECGSHAPTKTLLGIRAMVEQMKKEISDAAVVAGELQEAVHGDLRALLLLQQQQEQAENEKATTVASTEDTEAAATTTSFAAAAAGAVLKPVTLRGYLDQIHEALAQRARVSPVDGAVSAATLGHLLHVLSDPHLPITMSAQERQRMCQRLFFTLANSLAECTRTEALSCVCCMRCVLQDIVLPYKKSFMTEASAARVYHRCLSDTEADAFRMVQHMCDDVIMAVQKIALRSGILDEWKIVLVLQHLGDPLSLVRSTVEKLRSTVEKLTARRRGVIMDVIAQQLAIVKKSAARTGCGVADDVHCLFTLHPPSPPFSLPAAASAKAAVRAAEALTTSSSAAAMPAERSGSGRRRHGDRREKERRSEKDCKRDRDDSGSGDSSEHPWKKSRYRESKRHRTDFKRTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSV8</accession>
    <name>A0A088RSV8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Regulator of chromosome condensation, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_260730</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699894.1">
        <property type="nucleotide sequence ID" value="XM_010701592.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22575976"/>
    <dbReference type="KEGG" id="lpan:LPMP_260730"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260012100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_260730"/>
    <dbReference type="eggNOG" id="KOG1426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="263402at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF5">
        <property type="entry name" value="RCC DOMAIN-CONTAINING PROTEIN ATS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RCC1-like" evidence="5">
        <location>
            <begin position="591"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="610"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="783"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="835"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="1040"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="1093"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="1149"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="185"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="441"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1326"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1606"/>
            <end position="1666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="185"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1351"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1417"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1437"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1612"/>
            <end position="1623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN99187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1720" mass="180237" checksum="D137FB55FF123411" modified="2014-11-26" version="1">MEAACRRLCLGDTSSLPDIVDCIEAGQQAPTGKLGIRAYTALGTLLFREGLVLRESHASDSVLPSAGAFYALRILAVLGMRHAEEGYNVKSVLLSLGLQRCRDMILDAYFALKRWQRYYVVMFVTLLIGVYGCRPQDLLQSATSLNILAGSTDPGWVSPCPEGTAESTEVVPALPHHTAQVATASAGCSGSPASLTGPTNPQPPVATGSSPSPRRMSIQNHRPVRVSIPGTSTDLPVQPARWYRELPRSPINAPYSVNPLYVSEPLRESSGSTTAAGGRTGDDGADNRASPASQLLVAETAMTAQFPTPVVLFSAYHGVGCVPCLPTIDDLARLDAWRERKQQEHALKSPATASSSLTRIAERRHGWGFILEAALQMRDPDAAGDEGLSPPFVVRNEMAFVLPNPEAVAYHCQCLNSSLLRQYLEQGELLSWGSLAKGALGQHSQRRGRSTPGMPESDAISSDPAESKAKLSGGAPVTMGTPQQYSSAPGAAGLGGKEEQTSLAEGNLPTADPPMAASKALLARGPFATDVQPETRPTRGSVADQFQASPCGELKATSITSAESLAGSTASPHDTSVTGYVYLPLSVHTPARVAQIACGLAVTYVVTVDGVLYSCGRADNGQLGIGGRSMRYAHAGVSKLQRVLFKDNERVTRIAAGTACAVALTRDNALYCWGHNVYGQCLKMPDASRVLTPVRLKAGVHKVLDVCFGQFFGVLLFDDGVMGTWGIASMLGCNMSDKGLEHSLAPDQCKCARQVVHLRVGTSNPMAAVRAGPWHALAISQKGEVYTWGVGSNGRLGHGTDSSEVKPRLVEGLRSSFVVDASCSHVHSAVLTSTGAVYVFGGNAEGQLGLRGLAPRRLPTMVPLPIKAVAVMCAREHTCILLADGDVVACGSYRMCGIGLGYGRRFCAPMRILTNYVTMVLHSSYLQGMAGVVHRRTAVMVLGHSTIEEVSRVPSLSVRNGVRCAASGAGFLVVLWENNSLVAIGRGERGQLGIGDCMKSYRSDDVTVASAFSEVHIPSDVIIQHVRCGPDFALALDECGVVYGWGSNDHQKLCQPAGVAHIFTPVRVDAYASERIVQIVCGGTFVVALTVDGEVLAHGEAMYCGLGVSTSPAKAKGSDVSVPIRVAGLRDIVAVAAGCRHAVAMTASCSVFAWGVGVLGTGSNADTTDPASSASVVLTPVRVALSQTIRSIGCGPHNSFAINDEGELWVWGMNKFGECGIPTSGDSISTSSGGGALQDLAAGQKQGSDAAVGHANVITAPTPVARHVRDAAFTDQFGVVVFEDGQVSVSGRIRYGGQNYHLPTFHSTPQPPFSIDVNELVRYPPPELRPSLNASKLGGGGGASTAAASAQRQPGCQGSADSNSASEDENEQSESSHVGLPAASKPAKVSTDGQHQRRPQPPSLPRSHVVGMGMVASSPTSALSSKSSPQRANPSLPSVAGGHSSPPAPSSGAVTMAGALAPLAVPRDRLSSFTSPLSGTRDASQLDYRPDMMSEYFLPSLSGLIPSGEGSTHQATTAIKAGTMDTAEAYLYDTGYSSPDARAPLFKTEASREAVVCTPMPSHRVSDGAAPPSVQARTSTAAQARHSVPAAWGTLDVSETLALPLPPDRSTAQGAGAGMAAARAKVRRQPLQMPQPPQSAQRGQTARLPAGFKSPKLSLPSPPPSASDERILGIRCFAGWEQICILMEKYRPSAAEVGVAQRSLQVLLRQDRECSTGGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSX1</accession>
    <name>A0A088RSX1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPN-loop GTPase 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LPMP_251420</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699712.1">
        <property type="nucleotide sequence ID" value="XM_010701410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSX1"/>
    <dbReference type="GeneID" id="22575790"/>
    <dbReference type="KEGG" id="lpan:LPMP_251420"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250019900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_251420"/>
    <dbReference type="eggNOG" id="KOG1534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF7">
        <property type="entry name" value="GPN-LOOP GTPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIN99005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="237" mass="26221" checksum="87926B75D02E3F84" modified="2014-11-26" version="1">MGRSTHIANMDPAADSLPYEPSMDIRDLISLEDAMEGKGLGPNGGLVFCMEYLVTAGATWVSQQLGDYAEDFIIVDMPGQVEVLSNQPAVPAFVRLLQQEGYYTTVLYLLDALATTADSGKFIAGCMFSLSSMVCFDCPFINVLTKCDLLSKEFKENGVLEHFCMCDFDYMDLSRLPPRFRSMSRQVGALLTDFNLVTFRPVDIEEVGYVSNLCSVLDETLQVADEAEVQDHDLANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RSY9</accession>
    <name>A0A088RSY9_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LPMP_251570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009394">
        <property type="protein sequence ID" value="AIN99020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699727.1">
        <property type="nucleotide sequence ID" value="XM_010701425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RSY9"/>
    <dbReference type="GeneID" id="22575805"/>
    <dbReference type="KEGG" id="lpan:LPMP_251570"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_250012100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_251570"/>
    <dbReference type="eggNOG" id="ENOG502SBG4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273538at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="378"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIN99020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="542" mass="58258" checksum="9C488A62365F59C8" modified="2014-11-26" version="1">MEIASSSLKSLIEPLIDLIHGDLVLEDICCQRVAGAFVEHHEEALRRVVTSHTLPNGLEKAIEAYCVRSYLLKAPELPTQSHEVGRMLQRLADTLIEAARAPKGERQSERHDMESMCNEDEGARPSLAEVAEVEASSVADLLATSGEMIKKDVAALQARPEAQRCARLIDSLGEVVLGYIMYAAQQCAQQAQEYLGGATWHDTQMAHASYHATLHQFVRSAIEHREARRRAREAEVQALLFSNDHTVVVPAARAKDRDEVKEEDLIVVCEQDQHDASPAPSESPEVEFATHVRAAMEDIPASPQSPPQLLLKHPIPQTTSTRGGRVLHSLNDSVAEQCEALVHMSPPASLQGQEQQLSTPVRSSAPHPNALAAAEGQTSVPSEPTPSPEIVVDPLSLAVASSSLVTSAEGGGPHEGNDAARPPHRKLRKACTVLIGTSETSILRMVEHTKDDGREGGHLLSAAASGSASMASSTLPIGAQRPHGGRGTTGDTASSANSTTVSAVDAWEGVQRCLQRQDAEPRSYFLCGATHRFEPCVAKGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTA0</accession>
    <name>A0A088RTA0_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sphingosine kinase A, B, putative</fullName>
            <ecNumber evidence="8">2.7.1.91</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_260690</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.91" evidence="8"/>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699890.1">
        <property type="nucleotide sequence ID" value="XM_010701588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTA0"/>
    <dbReference type="GeneID" id="22575972"/>
    <dbReference type="KEGG" id="lpan:LPMP_260690"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260011700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_260690"/>
    <dbReference type="eggNOG" id="KOG1116">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3853857at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008481">
        <property type="term" value="F:sphingosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045540">
        <property type="entry name" value="YegS/DAGK_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF31">
        <property type="entry name" value="ACYLGLYCEROL KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19279">
        <property type="entry name" value="YegS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="7">
        <location>
            <begin position="205"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="648"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="478"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="648"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN99183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="817" mass="90375" checksum="95BE68AA12E8425A" modified="2014-11-26" version="1">MPAAYPWNLGAPQTVADKMEASVLNKGRICTLTYSPSRGAFRITRMSSSGKTRTVLNIPVRLIINIETAAERDARQRARQANDDTIRLVFAENSRGTGSLLCSFPSGTGEDNEALVFAHSRVNTASSTVGIQSGSLHRRTSSRFSTYADASLADTTAPGIRYYMHYVRQRNKGHPSIHTLEFQSSGSAEAVGCVVSQVVECIYQKGSKHIIVFISAKSGKGKGEHIFEKQVRPLLHFSRHTFHAYMTRRAHDCEDYVANLENPMNHNTVIATVGGDGMIHETVNGMHRRKLALVRWLRSVTTEVSTGDTPVVSPNMFLQLNDNGSCAEAGAQILPALCEGIWTVSSTELNSINKAALHNEAISGSHLPFIQLGWEEKKHNDDGRSGATSSVEATAREAHRLAHCLVQNGWDALMPLVATVATGSACGLAKSLDILSVAEAALSLVHLNTVHMDLLMMKFTPNEDMLEFHRGRMSAKRLEAAKRKFSQYEKDKAVELQERSRLKEEFHPHPQTLTAAEYAAPFLKDGSSVFRDAVSCATRMPELHSRVAFMSLSFGAANDIDHGSESLRWMGNARFHVYGGYMILRGLRGYKGILRYLPWESKAGKTVEKLHPRSRMPSTDDFPLCTMREGCMHCRQYKFTHCGASPLSSSTQVNETQPGPTSNISRSGVRASSAAATLAPYTDRELLHEEVVDFNDEHLPWVTIRGDFCFMLMCNLRDIAQDMLMAPLAHMSDGAIDVVYCRFDPTTGRRGRMEMLKFFMSLESGSHVNLEYVSYVKARALEIKVDAGISMSDGELMPLSSVRVTKMRGSVQLVRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTB2</accession>
    <name>A0A088RTB2_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thioredoxin-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_260890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699910.1">
        <property type="nucleotide sequence ID" value="XM_010701608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RTB2"/>
    <dbReference type="GeneID" id="22575992"/>
    <dbReference type="KEGG" id="lpan:LPMP_260890"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260013600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_260890"/>
    <dbReference type="eggNOG" id="ENOG502S07C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="423313at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIN99203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="171" mass="19510" checksum="46C5782345F0900C" modified="2014-11-26" version="1">MSPHGLRGADARFRPFLSSSLNEYLKRYWAIVFTVGSQAIDTGHMRHYVSWYATRLKVVELDHHIHATSLREQLIIKAGTPALPLLFVNEKLVGTIADVRSYEERRLLKDIVQFGFQWKTGAALDGAPQPLNTLPSPYSDTELFRGRYRGAPVARPVVQLPQLHPHRRQKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RTG4</accession>
    <name>A0A088RTG4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_260510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010699872.1">
        <property type="nucleotide sequence ID" value="XM_010701570.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22575954"/>
    <dbReference type="KEGG" id="lpan:LPMP_260510"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260009900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_260510"/>
    <dbReference type="eggNOG" id="ENOG502SKXM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="278776at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1031"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1072"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1150"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1181"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1324"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1356"/>
            <end position="1365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="1365" mass="150064" checksum="70D933E0C9E99C4B" modified="2014-11-26" version="1">MGRTPRCGPPPARAEEAPFSYVRRRSGSKSARRVASVTSAINAADLSSTVAYAQPARTRRRGIFMSRTQNMMFAVHKQARRYSQAEVNAMQESISLASPSLSASLSSTTSVPPLTVDPVPSCLHPLSQRRSTRAWDAIAAGCIAEARRLSEADNDVVAKAASFILGGNPNQGLFLLESHVIATCVVLHEQQEGVLSSASCLKRHDTVLADWLQHRSQFRADRSLQLPHCDVNPMRVTEAVVRHVVLQSMQLIDTVEVHRWYAVALVLCTLHETHDGNSSDRRSSKLKDSSKSKTFMSNFYGNGNCRGWSSTAVPAGDGQYWSERQGSTEFTAVLSTRPGRDTPTQSAAAVPATGAMSESDGYRAPSNVWFRYFFALCETTSPDGLLANTPFTQSTPPSKTHSQGTPPTTPWGRAPTARSTSAAMDVNGGSWPTDPAMRGRSGKLARTLSLFTGQHGGDITHGSSPSGDCQSRNSFCFSAPLSTQRAIPAWVTAALRPLDHEETTSLLLSHSTEWDVFFITAVTAFQTQHYRTCMMAASRFLHLVEAAGIMTQSIEASDHRANTRLSWLPTATHVLGLQEYQCRLALFVRAWSSLQVGERLQFGKDTVTLLDYAEDSFSYHVGCSLALFGLPLPAVKETVMTATAYFTRPVAKVTPPAARADSAGSFSPPVQVYLYVLTESVHALTLLQLGMMEAAMGVAKTALDRTKALRMCGNSAVDSDRCDALLLSTLRHVVVIAATALEDSTSVLEVSLLPDLLAYIAVCPGFFGGFSAGGIRVKAQSEAHRLLYPSTLPLYASTRQMIPFHMNRAVYLYHAGQLRGAWDDACCAVAAVDEVVGSVEFAFSDCFPLQVYYFTCHVGFILLEALLSADLEAAKACLSNPVSQEAIDKKDATLQGDEVLSKEILHLCQDVVGRMLHFYPHSRLGELCQVQLAIMRGEKHFLSHAILLSDRYPHNPAAQNLLTLALYFDHHVPEAVDNAVRNLQTFPHSREVILVHRLLQRKYVVYRFDYRGILPTRYKPGLAGQVVTKRMTFLLLLLAANVGVLCLTVFVNTSSVERASERMKALAVRMQVPSPVPLIFAAVFIIHTIVATATPHNLISTALTDLFFVNSALNRALFCLRCIPLVNLVNALLVSFAGNNFLFESGSATFFLYFFLSLLFVPFTTRVWFLPSVDEPDVNMMSWLAILSVDAVMAFIVVVPHIILTMLEPYMFVVFYFYAPTPRPGYGADRLPPSSSMRRRLLLHAHYGQSMTSRFQVGSGSRFVYICCLKWLYYRTHSSMETRYLAESQLEAENYRVFPMIEGEEARVLFSHVPLTPMCTTLTGTELDLPSDSPPHRSVTGRGGGEVLDRDRDGQGITSLTPLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVF2</accession>
    <name>A0A088RVF2_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="6">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LPMP_282680</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. PIF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="6"/>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700607.1">
        <property type="nucleotide sequence ID" value="XM_010702305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVF2"/>
    <dbReference type="GeneID" id="22576713"/>
    <dbReference type="KEGG" id="lpan:LPMP_282680"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280033300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_282680"/>
    <dbReference type="eggNOG" id="KOG0987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="432234at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF5">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="7">
        <location>
            <begin position="203"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN99900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="859" mass="94844" checksum="15F259651C1ACA18" modified="2014-11-26" version="1">MKPITATHALYSNLFQESFVNPFNGRLTGTSSLAAKLLCSVGFYRKVSNPLQLEWSPAEYMTTLQKIVSAEQLKAARRQERQARQERRVSKVAAKTRKLLAPATRQTRAGDSRAKLSAKCSVSGEAFMPVGEAMTSARSQLLRPFLRHGPDHWMANVAKLLERHDAFTYLHKELERLYSRLSAAYMTPKLDTPTDPSTVGMTITQDQRHVVKLALSGFNLFVGGSAGTGKTVLLKYIYRELSQMGLRVAMTATTGVTAVQLGGCTFHHAFNAPLDAAPHRWDANALRAVDVVIIDEVSLLDACMLDAFDMEARLARMHHRPFGGLQLIACGDFLQLSREDTLPAYESAAFTHLVSLRLVTPMRHAADDPLMRLLEDLRHGRFDTKCFAALDRPIPANSTHVTYLFPRRREAQQLNDLKLSELTTQEMTFTPQRGPLQLCGTFTHSALVELNRDADGMRAAMPHRERLLEMIREESQHVCAGGHRKDGGERELAPCVADHELVIMPVRTEGALVTRFALRLRCRERELPTSGTRGGCVGSADSGEDCTSTQPSVLSAGDVPALVVDPTHSGAPAAISVSTLRRPITTLATKRTRRIIAPFSAAEWEEIATAVATRLGGRVVTMLEEEPSSMVPLSVTMALADMTSSDVALSLAPLRLKLGCRVMVNRNLSRTVSNGSVGIVEAFAPPDINLFPRRTDRSARAVFQRVCQQKLFAQLPIVRLLGGEVVQIPPISITLGGTAQSYFYGHEVLTIPLQLGYAFTVHKVQGLTLQGTVVLDCEKFFDCAHLIYVACSRVRKLDQLVVYRVQPSMIIVRRSALEFSNKLQDARNLNVVDLPPSTARSSWSQHPHTQQRVFFSTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVN1</accession>
    <name>A0A088RVN1_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flagellar attachment zone protein 1 conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LPMP_262120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009395">
        <property type="protein sequence ID" value="AIN99324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700031.1">
        <property type="nucleotide sequence ID" value="XM_010701729.1"/>
    </dbReference>
    <dbReference type="GeneID" id="22576115"/>
    <dbReference type="KEGG" id="lpan:LPMP_262120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_260025900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_262120"/>
    <dbReference type="eggNOG" id="ENOG502SKQ4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267403at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056614">
        <property type="entry name" value="FAZ1_cons"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23398">
        <property type="entry name" value="FAZ1_cons"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flagellar attachment zone protein 1 conserved" evidence="2">
        <location>
            <begin position="1890"/>
            <end position="1971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="697"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1019"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1138"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1190"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1268"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1319"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1558"/>
            <end position="1609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1638"/>
            <end position="1665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1792"/>
            <end position="1811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="489"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="697"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="719"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1145"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1225"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1289"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1375"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1432"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1592"/>
            <end position="1605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1792"/>
            <end position="1805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIN99324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="2015" mass="210745" checksum="4E525F996468C9B3" modified="2014-11-26" version="1">MAALEQGNGEYAAISTISARPTRWSADVPLLLVPVRSALPDGSLLTCKGEAAHIARPPERLQLYQASSTVAEQDSRSGEADTSAYSGAEDVSAWWTVDIFIISVSSHCGSAHEGAAAMRAAALLRSPADMRAAHSIQCRAPVLPADASAEEAWDMTQSFLRCIALTSLRTFSPLCVPQGYFYFDTDFNQYVQLSADTLPLASTLFSVVMVAAGVDTPIVEEGCEGHAEMSDATAEGAQEVLGLRPCPVAQHHHMPPHASPPCDRDGAVPRHLWGDSAERGLTAITPRPPEGRPTSAPQHGPCPLAQPRSLVDIASAPSIAAGSSSRPRPAFDRRTSSNSPFNPEEKVPPYQRHPHRSCKAAVVSPDARGNDDSTGMILTYDGNSDEDGSYLMGWNGVENDVDDVVYGVASLPPLPLSYRDRTYGHYVDDYCAAWKRTGDVAGSQSSNVNVVYIDDNEAVLHAEAEEVTREAELRAAKAAERQFRASYGSNSISSNPDNPNCLQRFYNAPQSSKPPTHPLPTCPAAHGLLARLGSDSRAPAPRRPTAPAQGYSHVEVAATIRGPSSPPLPGPPLQPPPQQLFFDDPILQRHLQSPFKPSMSFSRPAAGSAEGCDGGRYPTYVPSPPRTAPAAPSPPHGAYMPVAHPYFDPSSSMGSYMPDCAPTPRFSAHTTEASTIAMNPAQRGALNALLQRSVQVWQQGHSSPTHCRQPPASPISSGDVDAAAAPPPVTTSTRPRPPRSAADVEVDSAASAVMVAIASTAYPLGASSFSSLSQPLPWSVTDATVLQGVVVPPPTSVELSTVTPMGHDCSSSPPKDECCSTTIGEADIPGEIEADALVSGHTAAAAVAALPEAHSGAVKTTTITADDVQNEAPVAVMPQDDQRDKEWAEQEYRTDTIPALEGGEEDEEAVGVHVDTHDDARRSTAVATAATTAADARGSRDGGGGTLWHLADTEATPMPGTDSRGGVVVEPNVVREALSGAHTPAHEEVSCKEQYDIDAGTELLPSVEEAETSPLAAAVEQPLPVREPPPKASEALFPAASAGPSHSPSPPHELLEEPSTATYVWATSLPSADGAREFSAGTSAAFSVNANDTAGGQNANASPTSTLVYSVAKEIPAADSSAPAHAAEGGDGVAASLEEHKESARTSPADTRMELSSSTESAEVEDLNIIPPVTAADALQGMHNVPADAPGLVESWRPSPVPPTAAPPAEYSAEVPRSQSDSHMAAGAEGPSESSSNVDQVDEVTDIAVADSVSGVSAHIVAAEAVGGIPATDSAAESVDTEQSSRQQEGADCRPKDSASDINDCAADESVARLKARPCPDDASLLSPEEQPSALTDAIAMKTGDDNGAATTREDEGEEEDLACSARPTRVAASEAHDEEHHAAAGKDSEAVPLLKRDDGAECSDNVKNKGDETLRETAAAGARQQKEACDASSSPQTLDSKGNDELGDAVAAEMAPSENEEEEEGSFSATANVNTLLSQPDMAAAAEVVAAGGDATPHVMTSASVFLPAPVFSVSTDREKEEDPDAPPQVLHHRAAVAAAAAAANAFYGLWEEWVTEDSTGDGDDPGGAGHVDTTAEGEDEEERDPSHPSTTSEAVTTTTITTTQNDYDGAVDVPMDVFRDSLSLTNTQILIRRCERRDEDTSVSATASLADPSDPPPHTVGSDMRLPLAQRRVTLMAYCDVDTDAADALSHFHHEEVSHAGAITDAVGEASTFDESGVDAEAPGNPTGGEVHVAPPSVVEALAPAMEVPQPLPAPSSAEISSSFVSTPSSSLAASQLVASPKEFLVQTNTNTDDDGNQFSSAMRGTEGLPDATNDEPHVAPFRSAAAHVDGSLLPLLEVPSDDGSDGAVKLKMPTTRAASEASAADVLQLPLPPRNDGAMKRTMVLLGFPGSVWELIMTHHYEGMHDAFTNDSAVAASVPISAIQDVRYSKGSLLVDFYVLHPASVDAVFIRDQMSNYSYPTLWAFYEAKKREQKRLLRSHGMSVAGAVPVQCLPVPSKPALSSHEEVGWTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVT4</accession>
    <name>A0A088RVT4_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LPMP_300070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP009399">
        <property type="protein sequence ID" value="AIO00243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010701043.1">
        <property type="nucleotide sequence ID" value="XM_010702741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVT4"/>
    <dbReference type="GeneID" id="22577061"/>
    <dbReference type="KEGG" id="lpan:LPMP_300070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_300005700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_300070"/>
    <dbReference type="eggNOG" id="ENOG502R0DD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275697at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIO00243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="240" mass="28006" checksum="8EE49C29088A4FFC" modified="2014-11-26" version="1">MRCCFPRLFQAGVHTPHGLRYNATRMKNWPVQEVPQNFNFTNEQRFKAKAMPRDTGKIPRDFLLSVLYRNQPCEVASLWEHCMNDPQIVLDSKRHLREVLQQARTEGFVSFEKDAVTDRWVCHLTRERFEEVRALVGARAETQDLYSGLRGASATETSAYSESFRKMNEDTKREHLRLLSEQVADTTAHLRKFQRMEMDYLPYTDLNGKVNFMWWYEMSDTRGAAALPEAEVEGSSKLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RVZ8</accession>
    <name>A0A088RVZ8_LEIPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid permease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">AAT23.2</name>
        <name evidence="8" type="ORF">LPMP_270670</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP009396">
        <property type="protein sequence ID" value="AIN99449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700156.1">
        <property type="nucleotide sequence ID" value="XM_010701854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RVZ8"/>
    <dbReference type="GeneID" id="22576243"/>
    <dbReference type="KEGG" id="lpan:LPMP_270670"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_270013600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_270670"/>
    <dbReference type="eggNOG" id="KOG1305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="438545at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF301">
        <property type="entry name" value="ACID TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="236"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="274"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="303"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="509"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="135"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIN99449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000063063"/>
        </source>
    </evidence>
    <sequence length="535" mass="58939" checksum="F8CDCB6D19F90121" modified="2014-11-26" version="1">MPTRGNHSANDALHLKHGQDRAVLDNMPEDPPEYGEDGLNMLNDDLNQEYLADEVVVGASDVDCKTEESKKADSSSFSGEREPVAEGYKQQLANIDIMQEILEAERRDREERVWRRRHTTNPVLRILQVIMPYGGILSSAFSIASSTIGGGIIGLPAAFQMSGIGMAVIYLMVVVTMAVYSFVLLAIVSHKTALYNWEIIARRLMGRGWDYFVVFVMWVLCFGGDVSYIIALKSILTGFLKNSPAASDYIKSEPGFRLITSMLWIVVILPMCVLKEINSLRIVSTVAILFVVFFTITCIIHSAQSLQERGMRDDLVVFQTGNTAIKGLSSLMFAFIAQVNAPEISREMYKFSVYRVFLSALLGMSLCAVLYFLTGLFGYLDFGPEVNDSILAMYNPLKDHLMAVSYAGMMLKICVGFALHLIPCRDCVYYMIGTDVSRVPWWKNALLCALQATGALAAGLFIPRITTVFGLLGGFCGGFVGFIFPALFMMYSGSFSVARVGWGHFLGTYALLLAGVIAVVWGTSAAIYGAVLSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A088RWU4</accession>
    <name>A0A088RWU4_LEIPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="9">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LPMP_280700</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania panamensis</name>
        <dbReference type="NCBI Taxonomy" id="5679"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
            <taxon>Leishmania guyanensis species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8550" last="8550">
            <title>The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.</title>
            <authorList>
                <person name="Llanes A."/>
                <person name="Restrepo C.M."/>
                <person name="Vecchio G.D."/>
                <person name="Anguizola F.J."/>
                <person name="Lleonart R."/>
            </authorList>
            <dbReference type="PubMed" id="25707621"/>
            <dbReference type="DOI" id="10.1038/srep08550"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MHOM/PA/94/PSC-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPP phosphatase family. PP-1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="9"/>
    <dbReference type="EMBL" id="CP009397">
        <property type="protein sequence ID" value="AIN99704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_010700411.1">
        <property type="nucleotide sequence ID" value="XM_010702109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A088RWU4"/>
    <dbReference type="GeneID" id="22576515"/>
    <dbReference type="KEGG" id="lpan:LPMP_280700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPAL13_280012500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LPMP_280700"/>
    <dbReference type="eggNOG" id="KOG0374">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000063063">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07414">
        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000047">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbRef
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